id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355186-7u4h083p	Kobak, Senol	Comment on “Colchicine may not be effective in COVID-19 infection; it may even be harmful?”	2020-06-20		.txt	text/plain	692	55	53	The main argument of the authors is that colchicine may have not increased the intracellular pH enough and cannot prevent the binding of the virus to the target angiotensin converting enzyme 2(ACE2) receptors. Also, they suggest that colchicine may increase the risk of acute respiratory distress syndrome(ARDS) and disseminated intravascular coagulation(DIC) which may occur during COVID-19 infection. There are no studies investigating the intracellular concentration of colchicine in corona infection, while such data exist regarding chloroquine [2] . When COVID-19 is passed into the cell via ACE2, activation of NLRP3 inflammasome is triggered by immunological mechanisms. Considering the mechanism of action of colchicine, it would make rationale use in patients with COVID-19 infection [8] . Recently, we reported COVID-19 infection in a patient with FMF under treatment with colchicine [9] . Covid-19 infection in a patient with FMF: does the colchicine have protective effect	./cache/cord-355186-7u4h083p.txt	./txt/cord-355186-7u4h083p.txt