id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355854-hksq8gy4	Pagliaro, Pasquale	ACE/ACE2 Ratio: A Key Also in 2019 Coronavirus Disease (Covid-19)?	2020-06-18		.txt	text/plain	3027	171	46	Therefore, we wonder whether the invasion by SARS-CoV-2 and the downregulation of ACE2 are jointly responsible for a high incidence of dramatic acute respiratory distress syndrome (ARDS), cardiovascular complications, and high lethality of Covid-19. Moreover, estrogen shifts the system toward the ACE2/Ang 1-7 formation and ACE2 activity is higher in female than that in the male serum (18) ; however, the worst and most lethal Covid-19 infections occur predominantly in males [the Italian ISS (https://www.epicentro.iss.it/coronavirus/ sars-cov-2-decessi-italia, accessed on April 26th 2020) reports that among 23,188 SARS-CoV-2 patients dying in Italy, women are 8,500 (36.7%)]. It has also been suggested that the increased concentration of ACE2 receptors in in the lungs of children may have a protective effect on severe clinical manifestations due to SARS-CoV-2 invasion (36) . ACE/ACE2 ratio is increased in many pathologies (especially dis-metabolisms and cardiovascular diseases) and conditions (obesity and aging) that exacerbate Covid-19 symptomatology and worsen outcomes.	./cache/cord-355854-hksq8gy4.txt	./txt/cord-355854-hksq8gy4.txt