id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-356150-ivso91ln	Torretta, Sara	Diagnosis of SARS-CoV-2 by RT-PCR Using Different Sample Sources: Review of the Literature	2020-08-31		.txt	text/plain	3497	195	48	2 Despite suboptimal detection rates, 3 collection of secretions from the upper airway by means of NPS/OPS still represents the first-line diagnostic modality to test patients and otherwise asymptomatic population for COVID-19, provided that it is early and adequately performed after onset of symptoms. 2 As a fact, reduced detection rates reflect analytical sensitivity of RT-PCR test and the epidemiologic characteristics of COVID-19, given that a false negative RT-PCR result could be possibly obtained both in the initial phase of the disease (ie, a few days before symptom onset) and at the ''tail end'' of SARS-CoV-2 infection (ie, from 20 days after symptom onset) due to a low viral load and a viral shedding below analytical RT-PCR sensitivity threshold. 3 On the basis of the reported detection rates, 4 the US Center for Disease Control and Prevention (US-CDC) has recommended the collection of sole upper respiratory NPS, 2 but the US Food and Drug Administration pointed out that a negative RT-PCR test result does not completely rule out SARS-CoV-2 infection and it shall not be used as a single element for patient management decisions.	./cache/cord-356150-ivso91ln.txt	./txt/cord-356150-ivso91ln.txt