key: cord-263664-isgcm4lj authors: Lee, Justin; Yousaf, Ahmed; Fang, Wei; Kolodney, Michael title: Male Balding is a Major Risk Factor for Severe COVID-19. date: 2020-07-22 journal: J Am Acad Dermatol DOI: 10.1016/j.jaad.2020.07.062 sha: doc_id: 263664 cord_uid: isgcm4lj nan This manuscript is original, has not been published before, and is not being considered for publication elsewhere. We know of no conflicts of interest associated with this publication and there has been no financial incentive for this work that could have influenced results. As the corresponding author, I can confirm that the manuscript has been read and approved for submission by the other named authors. Informed consent was obtained from all participants registered with the UK Biobank. 3 Options included the following text: pattern 1 "no hair loss," pattern 2 "slight hair loss," pattern 3 "moderate hair loss," pattern 4 "severe hair loss." 4 COVID-19 testing was carried out on symptomatic patients per National Health Service guidelines 5 . Descriptive frequencies for COVID-19 results, balding patterns, age, and BMI are reported in Our study compared a large sample of hospitalized COVID-19 positive patients to a control group of hospitalized COVID-19 negative patients and thus builds upon and supports the observations of Wambier 1 and coauthors. A notable limitation of our work is that balding data was self-reported. While the exact mechanism remains unknown, severe androgenic alopecia seems to be associated with hospitalization for COVID-19. The large effect of baldness on the risk of COVID-19 suggests that the presence of severe baldness may help clinicians and public health authorities identify and protect those at greatest risk. Figure 1. Descriptive frequencies for COVID-19 testing results, balding patterns, age, and BMI. Androgenetic Alopecia Present in the Majority of Hospitalized COVID-19 Patients -the "Gabrin sign A preliminary observation: Male pattern hair loss among hospitalized COVID-19 patients in Spain -A potential clue to the role of androgens in COVID-19 severity Male pattern baldness: classification and incidence Resource 100423 Screenshot from touchscreen questionnaire used to capture field 2395. UK Biobank Coronavirus staff guidance Inpatient Testing Protocol