key: cord-269445-dctx9c7w authors: Razanamahery, J.; Malinowski, L.; Humbert, S.; Brunel, A.S.; Lepiller, Q.; Chirouze, C.; Bouiller, K. title: Predictive factors of poor outcomes in the COVID-19 epidemic: Consider the inflammatory response date: 2020-04-24 journal: Med Mal Infect DOI: 10.1016/j.medmal.2020.04.016 sha: doc_id: 269445 cord_uid: dctx9c7w nan Dear editor, We read with interest the article by Wang et al., who assessed the usefulness of CRP levels in the early stage of COVID-19 to correlate with disease severity [1] . They showed that CRP levels were positively correlated with lung lesions and could reflect disease severity. These findings concurred with our prospective study. In December 2019, a new coronavirus emerged in Wuhan and rapidly spread through China and all over the world [2] . The pandemic of coronavirus disease 19 (COVID-19) is now responsible for more than 110,000 deaths in 178 countries (as of April 14, 2020), carrying a mortality rate from 3% to 7%. Clinical presentation is heterogenous from benign presentations to acute respiratory distress syndrome (ARDS) leading to intensive care unit (ICU) hospitalization or death [3, 4] . As a small proportion of patients suffer from severe conditions, there is an urgent need for early recognition of factors associated with poor outcome. The first patient of Besanç on University Hospital was identified on March 5, 2020 and from then on, the number of cases has rapidly increased. We aimed to identify risks factors for poor outcome of COVID-19 infection in hospitalized patients during the first month of the pandemic in Besanç on University Hospital. We retrieved records of patients hospitalized during the first month of the pandemic. Patients were hospitalized if they suffered from non-tolerable high-grade fever, shortness of breath or chest pain. Each COVID-19 diagnosis was confirmed using real-time reverse transcriptase polymerase chain reaction on nasopharyngeal samples. Oxygenation support was introduced for every patient with oxygen saturation (spO 2 ) below 94%. Every patient received first-line antibiotics for community-acquired pneumonia at admission. At the beginning of the study, no specific drugs were used to treat COVID-19 in our center. All patients received complete laboratory tests at admission, including acute phase reactants (i.e., C-reactive protein [CRP], procalcitonin [PCT], ferritin, fibrinogen), complete blood count, liver, and kidney function tests. Poor outcome was defined by transfer to the ICU and/or death. The study was conducted in accordance with the international review board of the institution. A total of 52 patients were included with a mean age of 65.3 ± 19.2 years with no difference between the two groups (P = 0.69). The mean duration between symptom onset and hospitalization was approximately 5.18 ± 4.22 days in both groups (P = 0.51). A total of 28 patients received oxygenation therapy; all patients without oxygenation support underwent physical examination or imaging demonstrating pneumonia. High levels of CRP, PCT, AST, and LDH were associated with poor outcome (Table 1) . However, CRP levels had the best accuracy (area under the curve 0.808) to predict poor outcome (Fig. 1) . CRP levels at 31.5 mg/L had sensitivity of 91% and specificity of 43%, whereas CRP levels at 98 mg/L had sensitivity of 67% but specificity of 80%. Ferritin levels appeared to be more elevated in the poor outcome group but were not significant (P = 0.11). No difference regarding blood counts and kidney/liver function was predictive of admission to the ICU or death (Table 1) . https://doi.org/10.1016/j.medmal.2020.04.016 0399-077X/© 2020 Elsevier Masson SAS. All rights reserved. COVID-19 has avidity for the respiratory tract and can induce ARDS in some patients. Our data confirms data from China showing that there is no initial kidney or liver failure [2] [3] [4] . The increase in AST levels is probably related to cell lysis and rhabdomyolysis, irrespective of ALT levels. We identified a group of patients with high inflammatory response associated with poor outcomes. As very low bacterial co-infection is reported in COVID-19, we hypothesized that inflammation was virus-related. CRP levels were the best predictive biological factors associated with poor outcome. Despite no statistical relevance in our study, high ferritin levels have already been described as predictor of acute respiratory distress syndrome [5] . Recent studies found that decreased lymphocyte counts and increased D-dimer concentrations might be an indication of negative prognosis. In addition, several biomarkers such as decreased albumin levels as well as elevated creatine kinase levels and higher LDH levels were associated with poor outcome of COVID-19 [6] . For those patients, the therapeutic approach including antiviral and/or anti-inflammatory treatments (steroids, IL-6 blockers, IL-1 blockers) should be initiated to avoid ARDS [7] [8] [9] . Moreover, hemophagocytic lymphohistiocytosis has to be considered in patients with high ferritin levels. There are some limitations to this study. First of all, it is a retrospective study with data collection based on the information available on the patient's records. Moreover, all patients hospitalized did not have standard complete biology performed at the beginning of the pandemic. Our major strength is that data was derived from a tertiary care center in Europe with high prevalence of COVID-19 infection. This data suggests simple laboratory test (CRP) to stratify the risk of poor outcome and guidance to therapeutic approach. All procedures performed in studies involving human particpants were in accordance with the 1964 Helsinki declaration and its later amendments. JR, KB, CC, and SH designed the study. JR, KB, and LM collected the data and wrote the initial draft. KB performed the statistical analysis. All authors contributed to editing the article, and approved the final version of the article. The authors declare that they have no competing interest. 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