key: cord-280540-yw8o3c1l authors: Patel, A. P.; Paranjpe, M. D.; Kathiresan, N. P.; Rivas, M. A.; Khera, A. V. title: Race, Socioeconomic Deprivation, and Hospitalization for COVID-19 in English participants of a National Biobank date: 2020-05-02 journal: medRxiv : the preprint server for health sciences DOI: 10.1101/2020.04.27.20082107 sha: doc_id: 280540 cord_uid: yw8o3c1l Preliminary reports suggest that the Coronavirus Disease 2019 (COVID-19) pandemic has led to disproportionate morbidity and mortality among historically disadvantaged populations. The extent to which these disparities are related to socioeconomic versus biologic factors is largely unknown. We investigate the racial and socioeconomic associations of COVID-19 hospitalization among 418,794 participants of the UK Biobank, of whom 549 (0.13%) had been hospitalized. Both black participants (odds ratio 3.4; 95%CI 2.4-4.9) and Asian participants (odds ratio 2.1; 95%CI 1.5-3.2) were at substantially increased risk as compared to white participants. We further observed a striking gradient in COVID-19 hospitalization rates according to the Townsend Deprivation Index - a composite measure of socioeconomic deprivation - and household income. Adjusting for such factors led to only modest attenuation of the increased risk in black participants, adjusted odds ratio 3.1 (95%CI 2.0-4.8). These observations confirm and extend earlier preliminary and lay press reports of higher morbidity in non-white individuals in the context of a large population of participants in a national biobank. The extent to which this increased risk relates to variation in pre-existing comorbidities, differences in testing or hospitalization patterns, or additional disparities in social determinants of health warrants further study. The Coronavirus Disease 2019 (COVID-19) pandemic has led to substantial morbidity and mortality globally, but initial reports suggest historically disadvantaged populations may be most afflicted. For example, a preliminary report from the United States Centers for Disease Control and Prevention indicated that 33% of hospitalized patients were black as compared to 18% of the U.S. population. 1 Within the densely populated and largely Hispanic suburb of Chelsea, Massachusetts, serologic tests suggested that up to 32% of individuals had been exposed. 2 The extent to which these disparities are related to socioeconomic versus biologic factors is largely unknown. All rights reserved. No reuse allowed without permission. was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The UK Biobank is a prospective cohort study that recruited over 500,000 middle-aged individuals between the years 2006 and 2010, allowing for linkage of extensive baseline, genetic and clinical data. 3 Recently, COVID-19 testing results for a subset of participants in England were made available. 4 Individuals were excluded from this analysis if they had enrolled outside England, died prior to 2019, or had an outpatient test positive for COVID-19, in whom the clinical trajectory was uncertain. Additional details are provided in the Supplementary Methods. All rights reserved. No reuse allowed without permission. was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint (which this version posted May 2, 2020. Figure, Panel A) . In a logistic regression model adjusted for age, sex, and geographic region, both black participants (odds ratio 3.4; 95%CI 2.4-4.9) and Asian participants (odds ratio 2.1; 95%CI 1.5-3.2) were at increased risk as compared to white participants. To understand the relationship between socioeconomic status and COVID-19 hospitalization, individuals were stratified at enrollment into deciles of the Townsend Deprivation Index, a previously validated composite metric based on employment status, car or home ownership, and household crowding. 5 Participants with greater Townsend Deprivation Indices were at substantially higher risk of COVID-19 hospitalization, with a similar pattern observed based on self-reported household income ( Figure, Panels B, C) . Index and household income--odds ratios for black and Asian participants of 3.1 (95%CI 2.0-4.8) and 2.0 (95%CI 1.2-3.1) as compared to white participants respectively. All rights reserved. No reuse allowed without permission. was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint (which this version posted May 2, 2020. . https://doi.org/10.1101/2020.04.27.20082107 doi: medRxiv preprint 5 Within a large population of participants in a national biobank, striking gradients in risk of hospitalization for COVID-19 were noted according to race and a metric of socioeconomic deprivation. The increased risk observed in black participants was attenuated but remained significant after adjusting for socioeconomic deprivation and household income. The extent to which this increased risk relates to variation in pre-existing cardiometabolic comorbidities, differences in testing or hospitalization patterns, or additional disparities in social determinants of health warrants further study. 6 With respect to potential biologic factors, ongoing efforts seek to determine whether genetics--known to both vary substantially across racial groups and contribute to pre-existing comorbidities--plays an important role in COVID-19 disease severity. This study has limitations. First, the UK Biobank enrolled individuals on a volunteer basis and is not a population-based study--additional efforts are needed to generalize these observations in other settings. Second, Townsend Deprivation Index and household income were assessed at enrollment, and participants' status may have changed in subsequent years. Third, additional and more sophisticated analytic techniques may prove useful in further disentangling COVID-19 related disparities. All rights reserved. No reuse allowed without permission. was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint (which this version posted May 2, 2020. . https://doi.org/10.1101/2020.04.27.20082107 doi: medRxiv preprint COVID-19) Chelsea show exposure to coronavirus -The Boston Globe The UK Biobank resource with deep phenotyping and genomic data Dynamic linkage of COVID-19 test results between Public Health England's Second Generation Surveillance System and UK Biobank. 2020:2163001 Bytes Health and Deprivation: Inequality and the North COVID-19 and African Americans All rights reserved. No reuse allowed without permission.was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which this version posted May 2, 2020. We are indebted to the UK Biobank and its participants who provided biological samples and data for this analysis. Work was performed under UK Biobank application #7089. Data analysis was approved by the Partners Healthcare institutional review board.All rights reserved. No reuse allowed without permission.was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which this version posted May 2, 2020. was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which this version posted May 2, 2020. . https://doi.org/10.1101/2020.04.27.20082107 doi: medRxiv preprint 9 (p<0.001). C: COVID-19 hospitalizations per 10,000 individuals by brackets of self-reported pretax household income. Pre-tax household income was significantly associated with COVID-19 hospitalization in an unadjusted model (p<0.001).All rights reserved. No reuse allowed without permission.was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which this version posted May 2, 2020. . https://doi.org/10.1101/2020.04.27.20082107 doi: medRxiv preprint