key: cord-293073-fu45h109 authors: Okano, Hideyuki; Seino, Ken-ichiro title: Steps towards COVID-19 suppression date: 2020-06-22 journal: Inflamm Regen DOI: 10.1186/s41232-020-00120-z sha: doc_id: 293073 cord_uid: fu45h109 nan Hideyuki Okano 1* and Ken-ichiro Seino 2* From a historical perspective, pandemics have been repeatedly caused by different pathogens, such as plague in the fourteenth century and cholera in the nineteenth century. Since the twentieth century, we have had the Spanish flu almost 100 years ago, the worst infectious disease in human history, and now the COVID-19 which is caused by SARS-CoV-2 infection [1] [2] [3] . COVID-19 pandemic is going to profoundly change the health, medicine, economy, and daily life of humanity around the world in this century. It is obvious that the suppression of COVID-19 is an urgent task for all humankind, but even if this is achieved, it has been pointed out that new pandemics may be triggered more frequently in the future due to not only outbreaks of new zoonosis caused by ecological, behavioral, or socioeconomic changes [4] but also the spread of various pathogens that have been isolated in the past as the permafrost in Siberia thaws due to global warming. Based on these scientific evidences and the latest predictive technologies, there is a need to establish diagnostic, therapeutic, and prophylactic methods, including vaccines, for COVID-19. In this theoretical series reviews, although it is not possible to cover all of the subjects mentioned above, we entitled this "COVID-19: its pathogenetic mechanisms and potential therapeutics" and invited leading researchers on COVID-19-related studies from the perspective of inflammation research and regenerative medicine and translational research, which are this journals' specialties, in addition to the basic properties and epidemiology of SARS-CoV-2 as follows: The basic properties and epidemiology of SARS-CoV-2: ➢ Dr. Nureki and colleagues will review the basic RNA and structural biology of SARS-CoV-2. ➢ Dr. Nakagawa and colleagues will review the comparative virology and genetics of SARS-CoV-2. Potential therapeutics for COVID-19 ➢ Dr. Terai and colleagues reviewed on therapeutic potential of mesenchymal stem cells (MSCs) and their exosomes in severe novel coronavirus disease 2019 (COVID-19) cases [5] . They described about basic aspects and mechanisms of action of MSCs and exosomes and potential of MSCs and exosome therapy in severe cases of COVID-19 in recently initiated or planned clinical trials registered in eight countries on ClinicalTrials.gov. ➢ Dr. Hashizume describes their current investigation on clinical trials for COVID-19-associated cytokine storm with tocilizumab. Prophylactic methods for COVID-19 ➢ Dr. Miyazawa and colleagues describe about herd immunity for COVID-19 pandemic. In addition to these invited reviews, we have opened a call for submissions reporting ongoing medical research in wide range of topics related to COVID-19, in the form of original articles, review articles, or opinion papers on the following topics (https://www.biomedcentral. com/collections/COVID19IPMPT). • Molecular biology and virology of SARS-CoV-2 • Clinical trials for COVID-19-related disorders Here, we would like to express sincere gratitude to the distinguished researchers who contributed to this theoretical series reviews and sincerely hope that these review articles will provide novel insights for the suppression of COVID-19 as well as to the researchers in the broad field of inflammation and regeneration. COVID-19) Pandemic. Geneva: World Health Organization What other countries can learn from Italy during the COVID-19 pandemic Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Prediction and prevention of the next pandemic zoonosis Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) cases Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Authors' contributions All authors read and approved the final manuscript. The authors declare that they have no competing interests.