key: cord-293896-dz9lzlqq
authors: Mian, Hira; Grant, Shakira J.; Engelhardt, Monika; Pawlyn, Charlotte; Bringhen, Sara; Zweegman, Sonja; Stege, Claudia A.M.; Rosko, Ashley E.; von Lilienfeld-Toal, Marie; Wildes, Tanya M.
title: Caring for older adults with multiple myeloma during the COVID-19 Pandemic: Perspective from the International Forum for Optimizing Care of Older Adults with Myeloma
date: 2020-04-17
journal: J Geriatr Oncol
DOI: 10.1016/j.jgo.2020.04.008
sha: 
doc_id: 293896
cord_uid: dz9lzlqq

nan

The novel coronavirus (SARS-CoV-2, COVID- 19) was first identified in the province of Wuhan, China in December 2019 [1] , following the emergence of new cases of pneumonia of unknown etiology. Since then, the manifestations of COVID-19 infections have ranged from asymptomatic to severe respiratory infections, with increased morbidity in older adults including those with co-morbidities and cancer [2, 3] . Presently, global mortality is reported at 4.7%, but this varies widely by location, from 0.7% in Germany to 10 .8% in Italy [4] . As of April 13, 2020, the number of infections continues to rise well beyond the 1.9 million cases, and approximately 120,000 COVID-19-related deaths that have already occurred globally [5] .

Multiple myeloma (MM) is a malignant plasma cell dyscrasia which predominantly affects older and often frail adults. Although tremendous gains have been made for older adults with MM, infections, including respiratory infections, significantly impact the rate of early mortality in these patients [6, 7] . Furthermore, older adults with MM have age-associated vulnerabilities leading to heterogeneity in outcomes [8] . The complexity of caring for older patients have increased substantially during this pandemic, due to concern about their risk of severe morbidity of COVID19 infection. Optimal strategies for these patients will involve staging the malignancy/aging, while simultaneously considering the local prevalence of COVID-19 infection. Herein, we discuss strategies for the risk reduction of COVID-19 transmission, treatment stratification of anti-myeloma therapy and discussion regarding goals of care for older adults with MM during the COVID-19 pandemic.

Currently there is an absence of data regarding both the prevalence and outcomes for older adults with MM exposed to COVID-19. In non-cancer patients, chronological age has emerged as a risk-factor for poor outcomes with COVID-19, although there is wide variation in the estimates presented. Early estimates from China suggest an overall case fatality rate of 2%, increasing to 8% for those aged 70-79 years and 15% for those ≥80 years of age [1] . Recent estimates from an Italian series of 1591 patients admitted to the intensive care unit demonstrated that older adults (n = 786; age ≥64 years) had higher mortality compared to younger patients (n = 795; age ≤63 years) (36% vs 15%; difference, 21%, 95% Confidence Interval [CI] , 17%-26%; P < .001) [9] . Similarly, in the United States, during March 1-28, 2020, laboratoryconfirmed COVID-19-associated hospitalization rate was 4.6 per 100,000 population with the highest rates among adults aged ≥65 years [10] . Increased number of overall comorbidities, including cardiovascular disease, diabetes, hypertension, chronic obstructive lung disease, accounted for the majority of severe COVID-19 infections and associated deaths [3, 10, 11] .

Additionally, patients with increasing number of co-morbidities had worse outcomes [11] , supporting the premise that the accumulation of vulnerabilities increases the risk of death, as is expected with other serious infections. Unfortunately, no data is available yet regarding other underlying geriatric impairments, such as functional dependence, in these patients.

With regards to prevalence/outcomes of the COVID-19 in adults with MM, there is a paucity of data and, apart from case reports [12] , estimates need to be extrapolated from case series published for other patients with cancer [2, 13, 14] Another retrospective case series, identified anti-tumour receipt within the last 14 days as a significant risk factor for severe events defined as a condition requiring admission to an intensive care unit, the use of mechanical ventilation, or death (Hazard Ratio=4.08, 95% CI 1.09-15.32;

P=0.04) [2] .

The above estimates yield the assumption that older adults with myeloma are at increased risk for poor outcomes due to a combination of demographics (older chronological age at diagnosis which is associated with increased co-morbidities and additional age-related vulnerabilities), disease-related (higher risk of secondary immunodeficiency [15] ) and treatmentrelated (anti-myeloma regimens that often require continuous administration) factors. While data confirming this assumption are needed, every effort should be made to decrease the risk of COVID-19 exposure in this patient population.

Physical distancing is the most pivotal and effective component of mitigating the risk.

One of the great challenges of this pandemic has been limitations in access to testing for the virus, a barrier which, in concert with the risk of asymptomatic individuals can transmit the virus, has led to a situation where physical interaction with the healthcare system may present a patient's greatest risk for exposure to the virus. Until widespread testing is available, efforts should be made to decrease physical contact with the health care system [16] . Despite physical distance, continued contact with the health care system via audio or video technologies is imperative to ensure ongoing care is provided during this time of increased vulnerability.

Disparities in both access and ability to utilize these advanced technologies among older adults needs to be recognized and, whenever possible, strategies devised to mitigate them. Alongside virtual visits, additional innovative strategies such as bloodwork-monitoring at home/local laboratories or couriering of medications to patients' home may also be required to further J o u r n a l P r e -p r o o f minimize risks. While risk-reduction strategies for COVID-19 should be emphasized, efforts should also be made to identify and address any other geriatric impairments such as nutrition, fall-risk, medication adherence, and mental-well-being using a multidisciplinary approach.

As clinicians struggle with optimizing care of older adults with MM during this pandemic, decisions regarding dose-reduction, regimen modification/interruption or continuation of therapy will need to be individualized based upon the concept of 'staging the disease' as well as 'staging the aging,' while adding in the complexity of the COVID pandemic.

'Staging the disease,' utilizing cytogenetics, Revised-International Staging System and response assessment, continues to hold prognostic value in older adults with NDMM [17, 18] and therefore should inform treatment decision-making during this time. In addition, tremendous progress has been made over the past decade in understanding the heterogeneity of aging beyond chronological age alone, termed 'staging the aging'. In MM, simple performance measures like Eastern Cooperative Oncology Group Performance Status (ECOG PS) contributes to the prognosis in older patients [19] , but beyond ECOG PS, frailty (defined as the complex syndrome of physiological decline that increases vulnerability [20] ) is a pivotal factor affecting outcomes in older patients, including progression-free survival, hospitalization, treatment-related toxicity, and overall survival [21] [22] [23] [24] .

Myeloma-specific frailty indices, such as the International Myeloma Working Group frailty index and the Revised Myeloma Co-Morbidity Index, have emerged as powerful tools in the 'personalization' of therapy for older adults by identifying those 'fit' individuals who may benefit from more aggressive treatment measures while simultaneously identifying 'frail'

patients at high-risk for adverse events [23, 24] . Simple physical performances measures like the

Journal Pre-proof 4 -meter walk test have also emerged as important strategies for risk-stratification of individuals with hematological malignancies, including MM [25] ; however, require in-person assessment.

Unfortunately, limited data exists on self-reported physical performance measures [26] , which can potentially be done during virtual appointments, among patients with MM.

While none of the above tools for staging the disease or aging were devised or have been validated to account for the unexpected challenges of COVID-19, they can be utilized for conceptualizing the treatment of older adults with MM during this challenging time.

Additionally, multiple international agencies have circulated guidance documents which are helpful as well [27] [28] [29] . Given the paucity of evidence-based data, treatment decisions need to be individualized as outlined in Figure 1 while taking into account the rapid changes in COVID-19 risk in each geographic area. Potential strategies during this time are outlined below; however, the risk/benefit ratio will need to be carefully evaluated for each individual: interim; however, careful attention should be paid to ensure these do not affect the ability to subsequently harvest stem cells. If it is not possible to delay ASCT, then consideration should be given to screening patients for COVID-19 before both stem cell procurement and prior to ASCT in accordance with established guidelines (e.g. ASTC and EBMT). [30, 33]  Drug regimens: While triplet regimens regimen using a combination of drugs has led to significant improvements in outcomes for both transplant-eligible and -ineligible older adults, careful consideration will need to be given to regimen selection at this time weighing the risks/benefits. Patients with uncontrolled disease will need to be managed with appropriate anti-myeloma therapy to prevent myeloma-related morbidity or mortality. Given the significant burden on resources, health care providers will need to advocate for this patient group to ensure access to appropriate therapy, access to care, and management of toxicities.

For adults with MM that is well-controlled, regimens that are well-tolerated should generally be continued, depending upon the presumed risk/severity of COVID-19

infection as outlined in Figure 2 . If new regimens are employed, consideration should be given to orally-administered therapy, while remaining vigilant regarding any barriers affecting medication adherence. During any therapy switch or initiation, efforts should be made to decrease the risk of treatment-related adverse events, which can lead to dose reduction or cessation of therapy altogether, which is associated with poor outcomes [32] .

Drug regimens associated with higher baseline risk of pulmonary toxicity need to be carefully considered in each individual case, weighing the pros and cons of therapy.

Given the potential immunosuppressive effects of steroids, consideration should be given J o u r n a l P r e -p r o o f 

In conclusion, as both clinicians and older adults with MM face this challenging time, shared decision-making has never been more important to personalize treatment during this pandemic, focusing on disease status as well as any aging-associated vulnerabilities. To further address the unique challenges faced by adults with MM and COVID-19 infection, ongoing efforts for collating data, such as those by the American Society of Hematology's Research

Collaborative data hub COVID-19 Registry and the international COVID-19 and Cancer

Consortium database, will be critical to filling the existing knowledge gaps about the epidemiology and outcomes of COVID-19 for subgroups of patients [34, 35] . Additionally, building new and innovative research platforms globally will allow us to not only meet the challenge of this pandemic but to also inform strategies for any future health care challenges among older adults with cancer. 

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