key: cord-303690-8h58rmwk authors: Michelozzi, Paola; de’Donato, Francesca; Scortichini, Matteo; De Sario, Manuela; Noccioli, Fiammetta; Rossi, Pasqualino; Davoli, Marina title: Mortality impacts of the coronavirus disease (COVID-19) outbreak by sex and age: rapid mortality surveillance system, Italy, 1 February to 18 April 2020 date: 2020-05-14 journal: Euro Surveill DOI: 10.2807/1560-7917.es.2020.25.19.2000620 sha: doc_id: 303690 cord_uid: 8h58rmwk Data from the rapid mortality surveillance system in 19 major Italian cities were used to carry out a timely assessment of the health impact of the COVID-19 epidemic. By 18 April, a + 45% excess in mortality was observed, with a higher impact in the north of the country (+ 76%). The excess was greatest among men, with an increasing trend by age. Surveillance data can be used to evaluate the lockdown and re-opening phases. Italy has been one of the countries worst hit by coronavirus disease , with over 185,000 cases and around 80% registered in north of the country [1] . Numbers in the initial phase of the outbreak in Italy seem to suggest a greater severity of the disease, with a higher case fatality rate (CFR) than previously observed in China (7.2% vs 2.3%) [2] . The aim of the study was to estimate the excess in total mortality by age and sex during the epidemic in Italian cities. Since 2004, Italy has had a rapid mortality surveillance system (SiSMG) for real-time monitoring of daily deaths in major Italian cities and allows routine evaluation of the health impact of extreme events and influenza epidemics [3, 4] . This surveillance system was a valuable tool for an early evaluation of the direct or indirect impact of COVID-19 on health. It is a standardised surveillance system capable of detecting variations in total mortality in the entire population rather than only on the infected cases, and it does not depend on a specific case definition (i.e. COVID-19-related deaths). Briefly, SiSMG is based on an ad hoc daily flow of mortality data (resident population by age and sex) from local Municipal Registry Offices to the Department of Epidemiology, Lazio Regional Health Authority -ASL Roma 1 (DEPLAZIO) which manages the system on behalf of the Ministry of Health [5, 6] . The standardised methodology to evaluate excess mortality typically used in the Italian national surveillance system was considered when estimating the excess related to COVID-19 [3, [5] [6] [7] . Specifically, the excess was defined as the difference between observed and baseline daily mortality (mean daily value by week and day of the week in the past 5 years). In this report, we show results for a subgroup of 19 cities, representative of almost all Italian regions, with timely updates of data, corresponding to 9 million residents (14% of the Italian population). Figure 1 shows the weekly trend in observed and expected (baseline) mortality in northern vs central and southern cities of Italy included in SiSMG. Shaded areas represent the confidence bands calculated as the estimated baseline +/− 1.96 × standard deviation of the series of observed deaths contributing to the baseline. From the first week of March, a steep rise in mortality was observed in cities in northern Italy ( Figure 1 ). From the start of the COVID-19 epidemic until 18 April, an overall 4,805 (+ 45%) excess deaths were observed in Italian cities, with a significantly higher excess in cities in the north (+ 76%, +4,295 deaths) compared with the centre and south (+ 10%, + 510 deaths). City-specific mortality data showed the highest excess in the cities in the north, especially Brescia (+ 197%) and Milan (+ 103%), Lombardy, Genoa, Liguria (+ 84%), Turin, Piedmont (+ 57%), Verona, Veneto (+ 40%) and Bologna and Emilia-Romagna (+ 47%). In contrast, the south and central cities recorded a more contained (+ 7% in Rome, + 20% in Messina) or no excess. Figure 2 shows excess mortality by sex and age groups among cities in the north and in the centre and south of Italy caused by the COVID-19 outbreak up until 3 April 2020. Overall, the excess in mortality was higher among men than among women in cities in the north vs the centre and south of Italy (men:+ 87% and + 70% and women: + 17% and + 9%, respectively), with an increasing trend by age. The greatest excess in the north was among elderly men (+ 76% in 65-74 yearolds, + 89% in 75-84 year-olds and + 102% in those 85 years and older). In central and southern Italy, the excess in mortality among men was lower, with a statistically significant excess only among elderly men: + 13% and + 28%, respectively, in the 75-84 years and ≥ 85 years age group. Our results confirm that the epidemic had the strongest impact in the most affected areas of the North. National COVID-19 data show that the Lombardy region alone accounted for 40% of cases in Italy, followed by the neighbouring regions of Emilia-Romagna (12%), Piedmont (12%) and Veneto (9%) [1] . It should be considered that these four northern regions accounted for ca 70% of national trade and economic activity [8] , which could have accelerated and amplified the spread of infection to and within this area of Italy. The regions of central and southern Italy registered nearly a week's delay in the outbreak and cases are to date much lower, with ca 20% of total cases [1] . Centralsouthern cities were comparatively less affected, possibly because containment measures were put in place before the emergency stage was reached. When considering the impact of COVID-19 mortality, we should take into account the low mortality of the 2019/20 winter, below the baseline from October to the end of February, which was attributable to the mild intensity of the influenza season and a warmer than average temperatures as shown in the latest SiSMG report [7] . This phenomenon of lower mortality may have led to a greater number of vulnerable individuals exposed to the COVID-19 epidemic, thus amplifying the impact on mortality in our country. Prevalence of chronic diseases is an important risk factor to take into account when analysing excess mortality related to COVID-19. Previous studies have shown that both disease severity and death risk are higher in patients with co-existing illnesses [9, 10] . Recent data from Italy show that ca 60% of COVID-19 deaths occurred in people with three or more comorbidities, mainly hypertension (69%), type-2 diabetes (32%), chronic renal failure (21%) and ischaemic heart disease (27%) [11] . In Italian cities, the higher mortality impact in men confirmed findings from a previous study in Italy [2] . Furthermore, experimental studies suggest that men are more susceptible to respiratory viral infections because of hormonal and epigenetic mechanisms involving innate immunity [12] . This has also been shown in animal studies for severe acute respiratory syndrome (SARS) coronavirus [13] . Another potential risk factor reported in the literature is smoking. Firstly, smoking is detrimental to the immune system and its responsiveness to infections and, specifically, it is able to upregulate the ACE-2 receptors in the airways, the key for SARS-CoV-2 virus entrance into the epithelial cells [10] . A recent review showed that smoking is most Data source: SiSMG surveillance system, Ministry of Health Italy [5, 6] . probably associated with a negative progression and adverse outcomes of COVID-19 [10, 14] . The higher prevalence of male smokers for all ages in Italy, especially among the elderly [15] , may explain their higher predisposition to COVID-19. Furthermore, the potential role of air pollution has been as a possible factor influencing COVID-19 transmission and an effect modifier of the number of cases [16, 17] . Populations with a chronic exposure to high levels of air pollution, such as in the north of Italy [18] , may have a greater predisposition to develop respiratory symptoms, which may make them more susceptible to COVID-19. However, evidence on the direct and indirect role of air pollution is to date limited and the causal pathways and the differential risk attributable to this in different geographical areas need to be further investigated. Considering our findings in the European context, the latest EuroMOMO bulletin shows a steep increase in excess all-cause mortality in several European countries, mostly in the age groups ≥ 65 and 15-64 years [19] . A comparison of official COVID-19 deaths in Europe and the United States suggests that adults younger than 65 years had a lower death risk than elderly people, with high geographical variability, and that more than 99% of deaths occurred among people with previous illnesses [20] . The different risk factors associated with COVID-19 predisposition and severity need to be taken into account when assessing the geographical heterogeneity in the risk of COVID-19-related deaths in the different population subgroups. Since the beginning of the Italian epidemic, efforts have been made to estimate the impact, which could possibly be greater than indicated by official data [1] because of a delay in death ascertainment and lack of specificity of COVID-19-related deaths. 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I dati per l'Italia: abitudine al fumo The short-term effects of air pollutants on influenza-like illness in Jinan, China Exposure to air pollution and COVID-19 mortality in the United States Estimation of daily PM10 and PM2.5 concentrations in Italy, 2013-2015, using a spatiotemporal land-use random-forest model The European mortality monitoring bulletin for week 15 Populationlevel COVID-19 mortality risk for non-elderly individuals overall and for nonelderly individuals without underlying diseases in pandemic epicenters The authors would like to acknowledge the Ministry of Health -CCM program for funding the SiSMG. None declared. PM planned the study and revised manuscript; FDD conceived the analysis plan and wrote manuscript and coordinate SiSMG; MS conceived and did the analysis and manage SiSMG; PR was in charge for overall direction and planning; MDS helped in writing manuscript; FN helped in SiSMG data management; MD contributed to the interpretation of the results and drafting the manuscript. All authors provided critical feedback and helped shape the research, analysis and manuscript. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence and indicate if changes were made.Any supplementary material referenced in the article can be found in the online version.