key: cord-338478-gkes9a16 authors: Haddad, S.; Tayyar, R.; Risch, L.; Churchill, G.; Fares, E.; Choe, M.; Montemuro, P. title: Encephalopathy and seizure activity in a COVID-19 well controlled HIV patient date: 2020-05-16 journal: IDCases DOI: 10.1016/j.idcr.2020.e00814 sha: doc_id: 338478 cord_uid: gkes9a16 A 41-year-old male with a history of well controlled HIV presented with confusion and was found to have COVID-19. Lumbar puncture was negative. He had worsening encephalopathy with tonic-clonic seizure requiring intubation. He was treated with hydroxychloroquine and azithromycin with improvement in mental status back to baseline after 6 days. COVID-19 who developed acute encephalopathy and tonic-clonic seizure activity. Case Report: A 41-year-old male with a past medical history of well controlled HIV, maintained on dolutegravir-lamivudine with last CD4 count of 604 cells/cu mm and an undetectable viral load two months prior to presentation and recurrent HSV on chronic suppressive therapy presented with abdominal pain, intractable vomiting, and confusion. He became ill six days prior to presentation when the patient started experiencing a dry cough and intermittent fever relieved by antipyretics. On day of presentation, he was only oriented to self. Remainder of symptoms and their development are outlined in Figure 1 . His epidemiologic risk factors for COVID-19 included indirect exposure to a COVID-19 positive patient. Full lab work on day of presentation including COVID-19 testing was performed. Results on day 1 (Table 1) were pertinent for leukopenia. EKG showed sinus tachycardia with first degree AV block and a QTc interval of 424 ms. No respiratory distress was noted. CT chest revealed diffuse patchy nodular ground glass infiltrates ( Figure 2 ). The remainder of imaging studies including CT head were unremarkable. Because the patient presented with acute encephalopathy in the setting of HIV, he underwent a lumbar puncture (Table 2 ) with no white cells noted in the cerebrospinal fluid. He was started on cefepime, ampicillin, vancomycin, and acyclovir for empiric bacterial meningitis and herpes encephalitis coverage. On day two of hospitalization, the patient was found to have worsening encephalopathy, agitation, and new-onset left sided ptosis. He subsequently developed witnessed tonicclonic seizure complicated by a tongue laceration leading to respiratory arrest requiring J o u r n a l P r e -p r o o f intubation and sedation. MRI performed at that time was unremarkable. An EEG showed evidence of diffuse slowing but no epileptiform activity. COVID-19 testing was noted to be positive and he was started on hydroxychloroquine 400 mg twice a day for one day followed by 200 mg twice a day for four days in addition to azithromycin 500 mg once followed by 250 mg daily for four days. Cefepime, ampicillin, and vancomycin were discontinued. Hospital course was further complicated by acute kidney injury which resolved after discontinuation of acyclovir on day 6 of presentation when HSV PCR was negative. On day 6 of hospitalization, the patient's level of consciousness improved off sedation ( Figure 3 ), and he was successfully extubated. Remdesivir was approved for compassionate use, however was not administered as patient had significant clinical improvement at that point. EKG on the day of discharge showed normal sinus rhythm with QTc interval of 501 ms. While the primary signs and symptoms of COVID-19 are fever, cough, and dyspnea, in rare cases, encephalopathy may be the predominant presenting symptom. In terms of neurologic manifestations, retrospective analyses have reported CVA, impaired consciousness, and anosmia, but severe encephalopathy has rarely been reported [4] . The patient's initial symptomatology included minimal respiratory complaints without oxygen requirements. He then quickly deteriorated, developing encephalopathy which was complicated by a witnessed seizure, as well as a cranial nerve palsy with left sided ptosis. A lumbar puncture did not reveal pleocytosis, indicating that COVID-19 likely did not cause a viral meningitis, although CSF PCR for COVID-19 was not done as it is not currently available in the United States. As this was the first atypical presentation of COVID-19 witnessed by the hospital J o u r n a l P r e -p r o o f staff, one of the main difficulties encountered was managing the patient's agitation while maintaining proper isolation precautions required for further imaging. This caused diagnostic delays and limited an expedient workup. Ultimately, MRI brain with and without contrast and EEG studies were obtained after the patient was intubated. Results were unremarkable, but could have been altered by the fact that the patient was sedated at the time of EEG, although benzodiazepines were not among the agents used for his sedation. A similar case was described in a patient with a prodrome of cough and fever, who subsequently developed altered mental status and became nonverbal. Antiepileptics were initiated prophylactically due to abnormal epileptiform discharges on EEG; however, this patient had preexisting encephalomalacia from a previous CVA [5] . This case presented many challenges as it was one of the first atypical presentations of COVID-19 witnessed by the hospital staff. One of the biggest challenges was the ability to secure a safe setting for further workup, including imaging and EEG, in an encephalopathic and agitated patient who tested positive for COVID-19. In times when agitation prevents safe transport of patients to imaging/testing, intubation and sedation despite the absence of life-threatening respiratory complications should be considered as an option to achieve safer conditions for necessary diagnostic imaging and testing. Several questions arise from this case. One question involves the patient's history of well controlled HIV and COVID-19-induced leukopenia. Are patients that are well controlled on antiretroviral therapy inherently at greater risk for being infected with COVID-19? Does COVID-19-induced leukopenia adversely affect this patient population despite having a normal CD4 count? Does this population suffer from more severe symptoms? All of these questions deserve further study. Another question involves the patient's neurologic manifestations of this disease. If further cases of seizure activity are reported in COVID-19 positive patients, the usefulness of prophylactic antiepileptics will need to be evaluated especially if they present with significant encephalopathy even in the absence of abnormal brain anatomy. Presently, COVID-19 is a viral entity that is not yet fully understood and its epileptogenic potential is yet unclear, but will hopefully be better elucidated with more studies. World Health Organization. WHO characterizes COVID-19 as a pandemic Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study Neurological complications of coronavirus disease (COVID-19): Encephalopathy