id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-030277-x9zvx3fp	Ohta, Yoshinori	Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial	2020-08-10		.txt	text/plain	4064	215	52	title: Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial We explored the effects of administering dexmedetomidine on the levels of C-reactive protein (CRP) and procalcitonin, and thus on inflammation, in patients with sepsis enrolled in a randomized clinical trial. METHODS: The DESIRE trial was a multicenter randomized clinical trial in which adult patients with sepsis were sedated with (DEX group) or without (non-DEX group) dexmedetomidine while on mechanical ventilators. We analyzed data derived from a randomized clinical trial and found that the administration of dexmedetomidine to patients with sepsis on ventilators improved CRP and PCT levels during the first 14 days in the ICU. In the present study, the use of dexmedetomidine for sedation reduced both CRP and PCT levels in patients with sepsis. Effect of dexmedetomidine on mortality and ventilator-free days in patients requiring mechanical ventilation with sepsis: a randomized clinical trial	./cache/cord-030277-x9zvx3fp.txt	./txt/cord-030277-x9zvx3fp.txt