id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006322-t7x86w9h	Rowin, Mark E.	Hypothermia Attenuates β1 Integrin Expression on Extravasated Neutrophils in an Animal Model of Meningitis	2001		.txt	text/plain	4376	271	32	This study examines whether hypothermia alters neutrophil integrin expression in a rabbit model of bacterial meningitis. We have previously demonstrated that extravasated CSF neutrophils in rabbits with group B streptococcal meningitis show a significant increase in expression of b1, activated b1, and b2 integrins (31) . Since the brain injury in meningitis occurs in part as a consequence of leukocyte activation and subsequent release of bioactive products, we speculate that hypothermia affects neutrophil function during the acute inflammatory response. Thus, this article examines expression of b1 and b2 integrins on extravasated neutrophils in normothermic and hypothermic animals using bacterial meningitis as a model of CNS inflammation. As is shown in Figure 1 , hypothermia significantly decreased total b1 integrin expression on neutrophils when compared to normothermic animals, with the relative fluorescence intensity decreasing to near baseline levels (RFI 1.18, P < 0.05).	./cache/cord-006322-t7x86w9h.txt	./txt/cord-006322-t7x86w9h.txt