id	sid	tid	token	lemma	pos
cord-032403-9c1xeqg1	1	1	key	key	NN
cord-032403-9c1xeqg1	1	2	:	:	:
cord-032403-9c1xeqg1	2	1	cord-032403	cord-032403	NN
cord-032403-9c1xeqg1	2	2	-	-	HYPH
cord-032403-9c1xeqg1	2	3	9c1xeqg1	9c1xeqg1	CD
cord-032403-9c1xeqg1	2	4	authors	author	NNS
cord-032403-9c1xeqg1	2	5	:	:	:
cord-032403-9c1xeqg1	2	6	Sokolov	Sokolov	NNP
cord-032403-9c1xeqg1	2	7	,	,	,
cord-032403-9c1xeqg1	2	8	Michael	Michael	NNP
cord-032403-9c1xeqg1	2	9	title	title	NN
cord-032403-9c1xeqg1	2	10	:	:	:
cord-032403-9c1xeqg1	2	11	Decision	decision	NN
cord-032403-9c1xeqg1	2	12	Making	making	NN
cord-032403-9c1xeqg1	2	13	and	and	CC
cord-032403-9c1xeqg1	2	14	Risk	Risk	NNP
cord-032403-9c1xeqg1	2	15	Management	Management	NNP
cord-032403-9c1xeqg1	2	16	in	in	IN
cord-032403-9c1xeqg1	2	17	Biopharmaceutical	Biopharmaceutical	NNP
cord-032403-9c1xeqg1	2	18	Engineering	Engineering	NNP
cord-032403-9c1xeqg1	2	19	—	—	:
cord-032403-9c1xeqg1	2	20	Opportunities	opportunity	NNS
cord-032403-9c1xeqg1	2	21	in	in	IN
cord-032403-9c1xeqg1	3	1	the	the	DT
cord-032403-9c1xeqg1	3	2	Age	Age	NNP
cord-032403-9c1xeqg1	3	3	of	of	IN
cord-032403-9c1xeqg1	3	4	Covid-19	Covid-19	NNP
cord-032403-9c1xeqg1	3	5	and	and	CC
cord-032403-9c1xeqg1	3	6	Digitalization	Digitalization	NNP
cord-032403-9c1xeqg1	3	7	date	date	NN
cord-032403-9c1xeqg1	3	8	:	:	:
cord-032403-9c1xeqg1	3	9	2020	2020	CD
cord-032403-9c1xeqg1	3	10	-	-	HYPH
cord-032403-9c1xeqg1	3	11	09	09	CD
cord-032403-9c1xeqg1	3	12	-	-	HYPH
cord-032403-9c1xeqg1	3	13	08	08	CD
cord-032403-9c1xeqg1	3	14	journal	journal	NN
cord-032403-9c1xeqg1	3	15	:	:	:
cord-032403-9c1xeqg1	4	1	Ind	Ind	NNP
cord-032403-9c1xeqg1	4	2	Eng	Eng	NNP
cord-032403-9c1xeqg1	4	3	Chem	Chem	NNP
cord-032403-9c1xeqg1	4	4	Res	Res	NNP
cord-032403-9c1xeqg1	4	5	DOI	doi	NN
cord-032403-9c1xeqg1	4	6	:	:	:
cord-032403-9c1xeqg1	5	1	10.1021	10.1021	CD
cord-032403-9c1xeqg1	5	2	/	/	SYM
cord-032403-9c1xeqg1	5	3	acs.iecr.0c02994	acs.iecr.0c02994	CC
cord-032403-9c1xeqg1	5	4	sha	sha	NNP
cord-032403-9c1xeqg1	5	5	:	:	:
cord-032403-9c1xeqg1	5	6	8023faf33fbd2b598244872efa004a6362779cbd	8023faf33fbd2b598244872efa004a6362779cbd	CD
cord-032403-9c1xeqg1	5	7	doc_id	doc_id	CD
cord-032403-9c1xeqg1	5	8	:	:	:
cord-032403-9c1xeqg1	5	9	32403	32403	CD
cord-032403-9c1xeqg1	5	10	cord_uid	cord_uid	NNS
cord-032403-9c1xeqg1	5	11	:	:	:
cord-032403-9c1xeqg1	6	1	9c1xeqg1	9c1xeqg1	CD
cord-032403-9c1xeqg1	7	1	[	[	-LRB-
cord-032403-9c1xeqg1	7	2	Image	image	NN
cord-032403-9c1xeqg1	7	3	:	:	:
cord-032403-9c1xeqg1	7	4	see	see	VB
cord-032403-9c1xeqg1	7	5	text	text	NN
cord-032403-9c1xeqg1	7	6	]	]	-RRB-
cord-032403-9c1xeqg1	8	1	In	in	IN
cord-032403-9c1xeqg1	8	2	2020	2020	CD
cord-032403-9c1xeqg1	8	3	,	,	,
cord-032403-9c1xeqg1	8	4	the	the	DT
cord-032403-9c1xeqg1	8	5	Covid-19	covid-19	NN
cord-032403-9c1xeqg1	8	6	pandemic	pandemic	NN
cord-032403-9c1xeqg1	8	7	resulted	result	VBD
cord-032403-9c1xeqg1	8	8	in	in	IN
cord-032403-9c1xeqg1	8	9	a	a	DT
cord-032403-9c1xeqg1	8	10	worldwide	worldwide	JJ
cord-032403-9c1xeqg1	8	11	challenge	challenge	NN
cord-032403-9c1xeqg1	8	12	without	without	IN
cord-032403-9c1xeqg1	8	13	an	an	DT
cord-032403-9c1xeqg1	8	14	evident	evident	JJ
cord-032403-9c1xeqg1	8	15	solution	solution	NN
cord-032403-9c1xeqg1	8	16	.	.	.
cord-032403-9c1xeqg1	9	1	Many	many	JJ
cord-032403-9c1xeqg1	9	2	persons	person	NNS
cord-032403-9c1xeqg1	9	3	and	and	CC
cord-032403-9c1xeqg1	9	4	authorities	authority	NNS
cord-032403-9c1xeqg1	9	5	involved	involve	VBN
cord-032403-9c1xeqg1	9	6	befriended	befriend	VBD
cord-032403-9c1xeqg1	9	7	the	the	DT
cord-032403-9c1xeqg1	9	8	value	value	NN
cord-032403-9c1xeqg1	9	9	of	of	IN
cord-032403-9c1xeqg1	9	10	available	available	JJ
cord-032403-9c1xeqg1	9	11	data	datum	NNS
cord-032403-9c1xeqg1	9	12	and	and	CC
cord-032403-9c1xeqg1	9	13	established	establish	VBN
cord-032403-9c1xeqg1	9	14	expertise	expertise	NN
cord-032403-9c1xeqg1	9	15	to	to	TO
cord-032403-9c1xeqg1	9	16	make	make	VB
cord-032403-9c1xeqg1	9	17	decisions	decision	NNS
cord-032403-9c1xeqg1	9	18	under	under	IN
cord-032403-9c1xeqg1	9	19	time	time	NN
cord-032403-9c1xeqg1	9	20	pressure	pressure	NN
cord-032403-9c1xeqg1	9	21	.	.	.
cord-032403-9c1xeqg1	10	1	This	this	DT
cord-032403-9c1xeqg1	10	2	omnipresent	omnipresent	JJ
cord-032403-9c1xeqg1	10	3	example	example	NN
cord-032403-9c1xeqg1	10	4	is	be	VBZ
cord-032403-9c1xeqg1	10	5	used	use	VBN
cord-032403-9c1xeqg1	10	6	to	to	TO
cord-032403-9c1xeqg1	10	7	illustrate	illustrate	VB
cord-032403-9c1xeqg1	10	8	the	the	DT
cord-032403-9c1xeqg1	10	9	decision	decision	NN
cord-032403-9c1xeqg1	10	10	-	-	HYPH
cord-032403-9c1xeqg1	10	11	making	make	VBG
cord-032403-9c1xeqg1	10	12	procedure	procedure	NN
cord-032403-9c1xeqg1	10	13	in	in	IN
cord-032403-9c1xeqg1	10	14	biopharmaceutical	biopharmaceutical	JJ
cord-032403-9c1xeqg1	10	15	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	10	16	.	.	.
cord-032403-9c1xeqg1	11	1	This	this	DT
cord-032403-9c1xeqg1	11	2	commentary	commentary	NN
cord-032403-9c1xeqg1	11	3	addresses	address	VBZ
cord-032403-9c1xeqg1	11	4	important	important	JJ
cord-032403-9c1xeqg1	11	5	challenges	challenge	NNS
cord-032403-9c1xeqg1	11	6	and	and	CC
cord-032403-9c1xeqg1	11	7	opportunities	opportunity	NNS
cord-032403-9c1xeqg1	11	8	to	to	TO
cord-032403-9c1xeqg1	11	9	support	support	VB
cord-032403-9c1xeqg1	11	10	risk	risk	NN
cord-032403-9c1xeqg1	11	11	management	management	NN
cord-032403-9c1xeqg1	11	12	in	in	IN
cord-032403-9c1xeqg1	11	13	biomanufacturing	biomanufacture	VBG
cord-032403-9c1xeqg1	11	14	through	through	IN
cord-032403-9c1xeqg1	11	15	a	a	DT
cord-032403-9c1xeqg1	11	16	process	process	NN
cord-032403-9c1xeqg1	11	17	-	-	HYPH
cord-032403-9c1xeqg1	11	18	centered	center	VBN
cord-032403-9c1xeqg1	11	19	digitalization	digitalization	NN
cord-032403-9c1xeqg1	11	20	approach	approach	NN
cord-032403-9c1xeqg1	11	21	combining	combine	VBG
cord-032403-9c1xeqg1	11	22	two	two	CD
cord-032403-9c1xeqg1	11	23	vital	vital	JJ
cord-032403-9c1xeqg1	11	24	worlds	world	NNS
cord-032403-9c1xeqg1	11	25	—	—	:
cord-032403-9c1xeqg1	11	26	formalized	formalize	VBN
cord-032403-9c1xeqg1	11	27	engineering	engineering	NN
cord-032403-9c1xeqg1	11	28	fundamentals	fundamental	NNS
cord-032403-9c1xeqg1	11	29	and	and	CC
cord-032403-9c1xeqg1	11	30	data	data	NN
cord-032403-9c1xeqg1	11	31	empowerment	empowerment	NN
cord-032403-9c1xeqg1	11	32	through	through	IN
cord-032403-9c1xeqg1	11	33	customized	customize	VBN
cord-032403-9c1xeqg1	11	34	machine	machine	NN
cord-032403-9c1xeqg1	11	35	learning	learning	NN
cord-032403-9c1xeqg1	11	36	.	.	.
cord-032403-9c1xeqg1	12	1	With	with	IN
cord-032403-9c1xeqg1	12	2	many	many	JJ
cord-032403-9c1xeqg1	12	3	enabling	enable	VBG
cord-032403-9c1xeqg1	12	4	technologies	technology	NNS
cord-032403-9c1xeqg1	12	5	already	already	RB
cord-032403-9c1xeqg1	12	6	available	available	JJ
cord-032403-9c1xeqg1	12	7	and	and	CC
cord-032403-9c1xeqg1	12	8	first	first	JJ
cord-032403-9c1xeqg1	12	9	success	success	NN
cord-032403-9c1xeqg1	12	10	stories	story	NNS
cord-032403-9c1xeqg1	12	11	reported	report	VBN
cord-032403-9c1xeqg1	12	12	,	,	,
cord-032403-9c1xeqg1	12	13	it	-PRON-	PRP
cord-032403-9c1xeqg1	12	14	will	will	MD
cord-032403-9c1xeqg1	12	15	depend	depend	VB
cord-032403-9c1xeqg1	12	16	on	on	IN
cord-032403-9c1xeqg1	12	17	the	the	DT
cord-032403-9c1xeqg1	12	18	interaction	interaction	NN
cord-032403-9c1xeqg1	12	19	of	of	IN
cord-032403-9c1xeqg1	12	20	different	different	JJ
cord-032403-9c1xeqg1	12	21	groups	group	NNS
cord-032403-9c1xeqg1	12	22	of	of	IN
cord-032403-9c1xeqg1	12	23	stakeholders	stakeholder	NNS
cord-032403-9c1xeqg1	12	24	how	how	WRB
cord-032403-9c1xeqg1	12	25	and	and	CC
cord-032403-9c1xeqg1	12	26	when	when	WRB
cord-032403-9c1xeqg1	12	27	the	the	DT
cord-032403-9c1xeqg1	12	28	huge	huge	JJ
cord-032403-9c1xeqg1	12	29	potential	potential	NN
cord-032403-9c1xeqg1	12	30	of	of	IN
cord-032403-9c1xeqg1	12	31	the	the	DT
cord-032403-9c1xeqg1	12	32	discussed	discuss	VBN
cord-032403-9c1xeqg1	12	33	technologies	technology	NNS
cord-032403-9c1xeqg1	12	34	will	will	MD
cord-032403-9c1xeqg1	12	35	be	be	VB
cord-032403-9c1xeqg1	12	36	broadly	broadly	RB
cord-032403-9c1xeqg1	12	37	and	and	CC
cord-032403-9c1xeqg1	12	38	systematically	systematically	RB
cord-032403-9c1xeqg1	12	39	realized	realize	VBN
cord-032403-9c1xeqg1	12	40	.	.	.
cord-032403-9c1xeqg1	13	1	In	in	IN
cord-032403-9c1xeqg1	13	2	2020	2020	CD
cord-032403-9c1xeqg1	13	3	,	,	,
cord-032403-9c1xeqg1	13	4	the	the	DT
cord-032403-9c1xeqg1	13	5	world	world	NN
cord-032403-9c1xeqg1	13	6	was	be	VBD
cord-032403-9c1xeqg1	13	7	shocked	shock	VBN
cord-032403-9c1xeqg1	13	8	by	by	IN
cord-032403-9c1xeqg1	13	9	the	the	DT
cord-032403-9c1xeqg1	13	10	Covid-19	covid-19	NN
cord-032403-9c1xeqg1	13	11	pandemic	pandemic	NN
cord-032403-9c1xeqg1	13	12	.	.	.
cord-032403-9c1xeqg1	14	1	In	in	IN
cord-032403-9c1xeqg1	14	2	many	many	JJ
cord-032403-9c1xeqg1	14	3	countries	country	NNS
cord-032403-9c1xeqg1	14	4	a	a	DT
cord-032403-9c1xeqg1	14	5	large	large	JJ
cord-032403-9c1xeqg1	14	6	number	number	NN
cord-032403-9c1xeqg1	14	7	of	of	IN
cord-032403-9c1xeqg1	14	8	restrictive	restrictive	JJ
cord-032403-9c1xeqg1	14	9	measures	measure	NNS
cord-032403-9c1xeqg1	14	10	have	have	VBP
cord-032403-9c1xeqg1	14	11	been	be	VBN
cord-032403-9c1xeqg1	14	12	introduced	introduce	VBN
cord-032403-9c1xeqg1	14	13	in	in	IN
cord-032403-9c1xeqg1	14	14	order	order	NN
cord-032403-9c1xeqg1	14	15	to	to	TO
cord-032403-9c1xeqg1	14	16	reduce	reduce	VB
cord-032403-9c1xeqg1	14	17	the	the	DT
cord-032403-9c1xeqg1	14	18	rate	rate	NN
cord-032403-9c1xeqg1	14	19	and	and	CC
cord-032403-9c1xeqg1	14	20	extent	extent	NN
cord-032403-9c1xeqg1	14	21	of	of	IN
cord-032403-9c1xeqg1	14	22	the	the	DT
cord-032403-9c1xeqg1	14	23	outbreak	outbreak	NN
cord-032403-9c1xeqg1	14	24	.	.	.
cord-032403-9c1xeqg1	15	1	The	the	DT
cord-032403-9c1xeqg1	15	2	pandemic	pandemic	NN
cord-032403-9c1xeqg1	15	3	has	have	VBZ
cord-032403-9c1xeqg1	15	4	spread	spread	VBN
cord-032403-9c1xeqg1	15	5	in	in	IN
cord-032403-9c1xeqg1	15	6	a	a	DT
cord-032403-9c1xeqg1	15	7	characteristic	characteristic	JJ
cord-032403-9c1xeqg1	15	8	sequence	sequence	NN
cord-032403-9c1xeqg1	15	9	from	from	IN
cord-032403-9c1xeqg1	15	10	Asia	Asia	NNP
cord-032403-9c1xeqg1	15	11	to	to	IN
cord-032403-9c1xeqg1	15	12	Europe	Europe	NNP
cord-032403-9c1xeqg1	15	13	and	and	CC
cord-032403-9c1xeqg1	15	14	then	then	RB
cord-032403-9c1xeqg1	15	15	to	to	IN
cord-032403-9c1xeqg1	15	16	the	the	DT
cord-032403-9c1xeqg1	15	17	rest	rest	NN
cord-032403-9c1xeqg1	15	18	of	of	IN
cord-032403-9c1xeqg1	15	19	the	the	DT
cord-032403-9c1xeqg1	15	20	world	world	NN
cord-032403-9c1xeqg1	15	21	.	.	.
cord-032403-9c1xeqg1	16	1	The	the	DT
cord-032403-9c1xeqg1	16	2	introduced	introduce	VBN
cord-032403-9c1xeqg1	16	3	country	country	NN
cord-032403-9c1xeqg1	16	4	-	-	HYPH
cord-032403-9c1xeqg1	16	5	specific	specific	JJ
cord-032403-9c1xeqg1	16	6	interventions	intervention	NNS
cord-032403-9c1xeqg1	16	7	strongly	strongly	RB
cord-032403-9c1xeqg1	16	8	vary	vary	VBP
cord-032403-9c1xeqg1	16	9	in	in	IN
cord-032403-9c1xeqg1	16	10	their	-PRON-	PRP$
cord-032403-9c1xeqg1	16	11	severity	severity	NN
cord-032403-9c1xeqg1	16	12	and	and	CC
cord-032403-9c1xeqg1	16	13	timeline	timeline	NN
cord-032403-9c1xeqg1	16	14	across	across	IN
cord-032403-9c1xeqg1	16	15	different	different	JJ
cord-032403-9c1xeqg1	16	16	,	,	,
cord-032403-9c1xeqg1	16	17	even	even	RB
cord-032403-9c1xeqg1	16	18	neighboring	neighboring	NN
cord-032403-9c1xeqg1	16	19	countries	country	NNS
cord-032403-9c1xeqg1	16	20	.	.	.
cord-032403-9c1xeqg1	17	1	During	during	IN
cord-032403-9c1xeqg1	17	2	such	such	PDT
cord-032403-9c1xeqg1	17	3	a	a	DT
cord-032403-9c1xeqg1	17	4	"	"	``
cord-032403-9c1xeqg1	17	5	lockdown	lockdown	NN
cord-032403-9c1xeqg1	17	6	"	"	''
cord-032403-9c1xeqg1	17	7	phase	phase	NN
cord-032403-9c1xeqg1	17	8	,	,	,
cord-032403-9c1xeqg1	17	9	1	1	CD
cord-032403-9c1xeqg1	17	10	which	which	WDT
cord-032403-9c1xeqg1	17	11	in	in	IN
cord-032403-9c1xeqg1	17	12	this	this	DT
cord-032403-9c1xeqg1	17	13	case	case	NN
cord-032403-9c1xeqg1	17	14	usually	usually	RB
cord-032403-9c1xeqg1	17	15	lasted	last	VBD
cord-032403-9c1xeqg1	17	16	over	over	IN
cord-032403-9c1xeqg1	17	17	more	more	JJR
cord-032403-9c1xeqg1	17	18	than	than	IN
cord-032403-9c1xeqg1	17	19	two	two	CD
cord-032403-9c1xeqg1	17	20	months	month	NNS
cord-032403-9c1xeqg1	17	21	,	,	,
cord-032403-9c1xeqg1	17	22	a	a	DT
cord-032403-9c1xeqg1	17	23	major	major	JJ
cord-032403-9c1xeqg1	17	24	goal	goal	NN
cord-032403-9c1xeqg1	17	25	is	be	VBZ
cord-032403-9c1xeqg1	17	26	to	to	TO
cord-032403-9c1xeqg1	17	27	monitor	monitor	VB
cord-032403-9c1xeqg1	17	28	the	the	DT
cord-032403-9c1xeqg1	17	29	situation	situation	NN
cord-032403-9c1xeqg1	17	30	and	and	CC
cord-032403-9c1xeqg1	17	31	to	to	TO
cord-032403-9c1xeqg1	17	32	collect	collect	VB
cord-032403-9c1xeqg1	17	33	sufficient	sufficient	JJ
cord-032403-9c1xeqg1	17	34	data	datum	NNS
cord-032403-9c1xeqg1	17	35	.	.	.
cord-032403-9c1xeqg1	18	1	2	2	LS
cord-032403-9c1xeqg1	19	1	In	in	IN
cord-032403-9c1xeqg1	19	2	the	the	DT
cord-032403-9c1xeqg1	19	3	era	era	NN
cord-032403-9c1xeqg1	19	4	of	of	IN
cord-032403-9c1xeqg1	19	5	digitalization	digitalization	NN
cord-032403-9c1xeqg1	19	6	and	and	CC
cord-032403-9c1xeqg1	19	7	globalization	globalization	NN
cord-032403-9c1xeqg1	19	8	,	,	,
cord-032403-9c1xeqg1	19	9	several	several	JJ
cord-032403-9c1xeqg1	19	10	organizations	organization	NNS
cord-032403-9c1xeqg1	19	11	have	have	VBP
cord-032403-9c1xeqg1	19	12	been	be	VBN
cord-032403-9c1xeqg1	19	13	able	able	JJ
cord-032403-9c1xeqg1	19	14	to	to	TO
cord-032403-9c1xeqg1	19	15	measure	measure	VB
cord-032403-9c1xeqg1	19	16	trends	trend	NNS
cord-032403-9c1xeqg1	19	17	based	base	VBN
cord-032403-9c1xeqg1	19	18	on	on	IN
cord-032403-9c1xeqg1	19	19	a	a	DT
cord-032403-9c1xeqg1	19	20	daily	daily	JJ
cord-032403-9c1xeqg1	19	21	updated	update	VBN
cord-032403-9c1xeqg1	19	22	display	display	NN
cord-032403-9c1xeqg1	19	23	of	of	IN
cord-032403-9c1xeqg1	19	24	available	available	JJ
cord-032403-9c1xeqg1	19	25	worldwide	worldwide	JJ
cord-032403-9c1xeqg1	19	26	information	information	NN
cord-032403-9c1xeqg1	19	27	.	.	.
cord-032403-9c1xeqg1	20	1	3	3	CD
cord-032403-9c1xeqg1	20	2	,	,	,
cord-032403-9c1xeqg1	20	3	4	4	CD
cord-032403-9c1xeqg1	21	1	This	this	DT
cord-032403-9c1xeqg1	21	2	has	have	VBZ
cord-032403-9c1xeqg1	21	3	been	be	VBN
cord-032403-9c1xeqg1	21	4	essential	essential	JJ
cord-032403-9c1xeqg1	21	5	to	to	TO
cord-032403-9c1xeqg1	21	6	plan	plan	VB
cord-032403-9c1xeqg1	21	7	next	next	JJ
cord-032403-9c1xeqg1	21	8	steps	step	NNS
cord-032403-9c1xeqg1	21	9	,	,	,
cord-032403-9c1xeqg1	21	10	while	while	IN
cord-032403-9c1xeqg1	21	11	reducing	reduce	VBG
cord-032403-9c1xeqg1	21	12	risks	risk	NNS
cord-032403-9c1xeqg1	21	13	for	for	IN
cord-032403-9c1xeqg1	21	14	the	the	DT
cord-032403-9c1xeqg1	21	15	health	health	NN
cord-032403-9c1xeqg1	21	16	system	system	NN
cord-032403-9c1xeqg1	21	17	such	such	JJ
cord-032403-9c1xeqg1	21	18	as	as	IN
cord-032403-9c1xeqg1	21	19	operative	operative	JJ
cord-032403-9c1xeqg1	21	20	or	or	CC
cord-032403-9c1xeqg1	21	21	capacity	capacity	NN
cord-032403-9c1xeqg1	21	22	bottlenecks	bottleneck	NNS
cord-032403-9c1xeqg1	21	23	.	.	.
cord-032403-9c1xeqg1	22	1	Despite	despite	IN
cord-032403-9c1xeqg1	22	2	different	different	JJ
cord-032403-9c1xeqg1	22	3	governmental	governmental	JJ
cord-032403-9c1xeqg1	22	4	strategies	strategy	NNS
cord-032403-9c1xeqg1	22	5	to	to	TO
cord-032403-9c1xeqg1	22	6	address	address	VB
cord-032403-9c1xeqg1	22	7	the	the	DT
cord-032403-9c1xeqg1	22	8	problem	problem	NN
cord-032403-9c1xeqg1	22	9	,	,	,
cord-032403-9c1xeqg1	22	10	all	all	DT
cord-032403-9c1xeqg1	22	11	of	of	IN
cord-032403-9c1xeqg1	22	12	them	-PRON-	PRP
cord-032403-9c1xeqg1	22	13	strongly	strongly	RB
cord-032403-9c1xeqg1	22	14	rely	rely	VBP
cord-032403-9c1xeqg1	22	15	on	on	IN
cord-032403-9c1xeqg1	22	16	the	the	DT
cord-032403-9c1xeqg1	22	17	concept	concept	NN
cord-032403-9c1xeqg1	22	18	of	of	IN
cord-032403-9c1xeqg1	22	19	social	social	JJ
cord-032403-9c1xeqg1	22	20	distancing	distancing	NN
cord-032403-9c1xeqg1	22	21	,	,	,
cord-032403-9c1xeqg1	22	22	the	the	DT
cord-032403-9c1xeqg1	22	23	adherence	adherence	NN
cord-032403-9c1xeqg1	22	24	to	to	TO
cord-032403-9c1xeqg1	22	25	which	which	WDT
cord-032403-9c1xeqg1	22	26	is	be	VBZ
cord-032403-9c1xeqg1	22	27	difficult	difficult	JJ
cord-032403-9c1xeqg1	22	28	to	to	TO
cord-032403-9c1xeqg1	22	29	monitor	monitor	VB
cord-032403-9c1xeqg1	22	30	and	and	CC
cord-032403-9c1xeqg1	22	31	control	control	VB
cord-032403-9c1xeqg1	22	32	across	across	IN
cord-032403-9c1xeqg1	22	33	society	society	NN
cord-032403-9c1xeqg1	22	34	.	.	.
cord-032403-9c1xeqg1	23	1	Such	such	JJ
cord-032403-9c1xeqg1	23	2	limited	limited	JJ
cord-032403-9c1xeqg1	23	3	control	control	NN
cord-032403-9c1xeqg1	23	4	is	be	VBZ
cord-032403-9c1xeqg1	23	5	often	often	RB
cord-032403-9c1xeqg1	23	6	present	present	JJ
cord-032403-9c1xeqg1	23	7	when	when	WRB
cord-032403-9c1xeqg1	23	8	trying	try	VBG
cord-032403-9c1xeqg1	23	9	to	to	TO
cord-032403-9c1xeqg1	23	10	solve	solve	VB
cord-032403-9c1xeqg1	23	11	a	a	DT
cord-032403-9c1xeqg1	23	12	problem	problem	NN
cord-032403-9c1xeqg1	23	13	,	,	,
cord-032403-9c1xeqg1	23	14	which	which	WDT
cord-032403-9c1xeqg1	23	15	is	be	VBZ
cord-032403-9c1xeqg1	23	16	relatively	relatively	RB
cord-032403-9c1xeqg1	23	17	new	new	JJ
cord-032403-9c1xeqg1	23	18	as	as	RB
cord-032403-9c1xeqg1	23	19	well	well	RB
cord-032403-9c1xeqg1	23	20	as	as	IN
cord-032403-9c1xeqg1	23	21	subject	subject	JJ
cord-032403-9c1xeqg1	23	22	to	to	IN
cord-032403-9c1xeqg1	23	23	many	many	JJ
cord-032403-9c1xeqg1	23	24	potentially	potentially	RB
cord-032403-9c1xeqg1	23	25	influential	influential	JJ
cord-032403-9c1xeqg1	23	26	factors	factor	NNS
cord-032403-9c1xeqg1	23	27	,	,	,
cord-032403-9c1xeqg1	23	28	with	with	IN
cord-032403-9c1xeqg1	23	29	some	some	DT
cord-032403-9c1xeqg1	23	30	of	of	IN
cord-032403-9c1xeqg1	23	31	them	-PRON-	PRP
cord-032403-9c1xeqg1	23	32	difficult	difficult	JJ
cord-032403-9c1xeqg1	23	33	to	to	TO
cord-032403-9c1xeqg1	23	34	quantify	quantify	VB
cord-032403-9c1xeqg1	23	35	or	or	CC
cord-032403-9c1xeqg1	23	36	to	to	TO
cord-032403-9c1xeqg1	23	37	predict	predict	VB
cord-032403-9c1xeqg1	23	38	.	.	.
cord-032403-9c1xeqg1	24	1	During	during	IN
cord-032403-9c1xeqg1	24	2	the	the	DT
cord-032403-9c1xeqg1	24	3	Covid-19	covid-19	NN
cord-032403-9c1xeqg1	24	4	crisis	crisis	NN
cord-032403-9c1xeqg1	24	5	,	,	,
cord-032403-9c1xeqg1	24	6	it	-PRON-	PRP
cord-032403-9c1xeqg1	24	7	has	have	VBZ
cord-032403-9c1xeqg1	24	8	become	become	VBN
cord-032403-9c1xeqg1	24	9	broadly	broadly	RB
cord-032403-9c1xeqg1	24	10	evident	evident	JJ
cord-032403-9c1xeqg1	24	11	how	how	WRB
cord-032403-9c1xeqg1	24	12	essential	essential	JJ
cord-032403-9c1xeqg1	24	13	the	the	DT
cord-032403-9c1xeqg1	24	14	availability	availability	NN
cord-032403-9c1xeqg1	24	15	of	of	IN
cord-032403-9c1xeqg1	24	16	data	data	NN
cord-032403-9c1xeqg1	24	17	is	be	VBZ
cord-032403-9c1xeqg1	24	18	for	for	IN
cord-032403-9c1xeqg1	24	19	decision	decision	NN
cord-032403-9c1xeqg1	24	20	-	-	HYPH
cord-032403-9c1xeqg1	24	21	making	making	NN
cord-032403-9c1xeqg1	24	22	for	for	IN
cord-032403-9c1xeqg1	24	23	complex	complex	JJ
cord-032403-9c1xeqg1	24	24	problems	problem	NNS
cord-032403-9c1xeqg1	24	25	,	,	,
cord-032403-9c1xeqg1	24	26	and	and	CC
cord-032403-9c1xeqg1	24	27	how	how	WRB
cord-032403-9c1xeqg1	24	28	unstable	unstable	JJ
cord-032403-9c1xeqg1	24	29	such	such	JJ
cord-032403-9c1xeqg1	24	30	decision	decision	NN
cord-032403-9c1xeqg1	24	31	processes	process	NNS
cord-032403-9c1xeqg1	24	32	can	can	MD
cord-032403-9c1xeqg1	24	33	become	become	VB
cord-032403-9c1xeqg1	24	34	when	when	WRB
cord-032403-9c1xeqg1	24	35	the	the	DT
cord-032403-9c1xeqg1	24	36	data	datum	NNS
cord-032403-9c1xeqg1	24	37	are	be	VBP
cord-032403-9c1xeqg1	24	38	biased	bias	VBN
cord-032403-9c1xeqg1	24	39	by	by	IN
cord-032403-9c1xeqg1	24	40	uncertainty	uncertainty	NN
cord-032403-9c1xeqg1	24	41	and	and	CC
cord-032403-9c1xeqg1	24	42	lack	lack	NN
cord-032403-9c1xeqg1	24	43	of	of	IN
cord-032403-9c1xeqg1	24	44	prior	prior	JJ
cord-032403-9c1xeqg1	24	45	expertise	expertise	NN
cord-032403-9c1xeqg1	24	46	.	.	.
cord-032403-9c1xeqg1	25	1	5	5	LS
cord-032403-9c1xeqg1	26	1	Although	although	IN
cord-032403-9c1xeqg1	26	2	with	with	IN
cord-032403-9c1xeqg1	26	3	a	a	DT
cord-032403-9c1xeqg1	26	4	different	different	JJ
cord-032403-9c1xeqg1	26	5	complexity	complexity	NN
cord-032403-9c1xeqg1	26	6	and	and	CC
cord-032403-9c1xeqg1	26	7	effect	effect	NN
cord-032403-9c1xeqg1	26	8	on	on	IN
cord-032403-9c1xeqg1	26	9	society	society	NN
cord-032403-9c1xeqg1	26	10	,	,	,
cord-032403-9c1xeqg1	26	11	the	the	DT
cord-032403-9c1xeqg1	26	12	biopharmaceutical	biopharmaceutical	JJ
cord-032403-9c1xeqg1	26	13	industry	industry	NN
cord-032403-9c1xeqg1	26	14	faces	face	VBZ
cord-032403-9c1xeqg1	26	15	an	an	DT
cord-032403-9c1xeqg1	26	16	analogous	analogous	JJ
cord-032403-9c1xeqg1	26	17	uncertaintydriven	uncertaintydriven	JJ
cord-032403-9c1xeqg1	26	18	environment	environment	NN
cord-032403-9c1xeqg1	26	19	on	on	IN
cord-032403-9c1xeqg1	26	20	a	a	DT
cord-032403-9c1xeqg1	26	21	daily	daily	JJ
cord-032403-9c1xeqg1	26	22	basis	basis	NN
cord-032403-9c1xeqg1	26	23	in	in	IN
cord-032403-9c1xeqg1	26	24	their	-PRON-	PRP$
cord-032403-9c1xeqg1	26	25	workstream	workstream	NN
cord-032403-9c1xeqg1	26	26	.	.	.
cord-032403-9c1xeqg1	27	1	6	6	CD
cord-032403-9c1xeqg1	28	1	The	the	DT
cord-032403-9c1xeqg1	28	2	biopharmaceutical	biopharmaceutical	JJ
cord-032403-9c1xeqg1	28	3	sector	sector	NN
cord-032403-9c1xeqg1	28	4	is	be	VBZ
cord-032403-9c1xeqg1	28	5	a	a	DT
cord-032403-9c1xeqg1	28	6	dominantly	dominantly	RB
cord-032403-9c1xeqg1	28	7	growing	grow	VBG
cord-032403-9c1xeqg1	28	8	branch	branch	NN
cord-032403-9c1xeqg1	28	9	of	of	IN
cord-032403-9c1xeqg1	28	10	the	the	DT
cord-032403-9c1xeqg1	28	11	pharma	pharma	NNS
cord-032403-9c1xeqg1	28	12	industry	industry	NN
cord-032403-9c1xeqg1	28	13	7	7	CD
cord-032403-9c1xeqg1	28	14	with	with	IN
cord-032403-9c1xeqg1	28	15	prominent	prominent	JJ
cord-032403-9c1xeqg1	28	16	blockbuster	blockbuster	JJ
cord-032403-9c1xeqg1	28	17	therapeutic	therapeutic	JJ
cord-032403-9c1xeqg1	28	18	protein	protein	NN
cord-032403-9c1xeqg1	28	19	products	product	NNS
cord-032403-9c1xeqg1	28	20	such	such	JJ
cord-032403-9c1xeqg1	28	21	as	as	IN
cord-032403-9c1xeqg1	28	22	Humira	Humira	NNP
cord-032403-9c1xeqg1	28	23	(	(	-LRB-
cord-032403-9c1xeqg1	28	24	adalimumab	adalimumab	NNP
cord-032403-9c1xeqg1	28	25	)	)	-RRB-
cord-032403-9c1xeqg1	28	26	and	and	CC
cord-032403-9c1xeqg1	28	27	Rituxan	Rituxan	NNP
cord-032403-9c1xeqg1	28	28	(	(	-LRB-
cord-032403-9c1xeqg1	28	29	rituximab	rituximab	NNP
cord-032403-9c1xeqg1	28	30	)	)	-RRB-
cord-032403-9c1xeqg1	28	31	.	.	.
cord-032403-9c1xeqg1	29	1	8	8	CD
cord-032403-9c1xeqg1	30	1	This	this	DT
cord-032403-9c1xeqg1	30	2	industry	industry	NN
cord-032403-9c1xeqg1	30	3	uses	use	VBZ
cord-032403-9c1xeqg1	30	4	as	as	IN
cord-032403-9c1xeqg1	30	5	one	one	CD
cord-032403-9c1xeqg1	30	6	of	of	IN
cord-032403-9c1xeqg1	30	7	the	the	DT
cord-032403-9c1xeqg1	30	8	principle	principle	JJ
cord-032403-9c1xeqg1	30	9	unit	unit	NN
cord-032403-9c1xeqg1	30	10	operations	operation	VBZ
cord-032403-9c1xeqg1	30	11	a	a	DT
cord-032403-9c1xeqg1	30	12	biotechnological	biotechnological	JJ
cord-032403-9c1xeqg1	30	13	process	process	NN
cord-032403-9c1xeqg1	30	14	based	base	VBN
cord-032403-9c1xeqg1	30	15	on	on	IN
cord-032403-9c1xeqg1	30	16	a	a	DT
cord-032403-9c1xeqg1	30	17	living	live	VBG
cord-032403-9c1xeqg1	30	18	organism	organism	NN
cord-032403-9c1xeqg1	30	19	to	to	TO
cord-032403-9c1xeqg1	30	20	produce	produce	VB
cord-032403-9c1xeqg1	30	21	highly	highly	RB
cord-032403-9c1xeqg1	30	22	specific	specific	JJ
cord-032403-9c1xeqg1	30	23	drugs	drug	NNS
cord-032403-9c1xeqg1	30	24	targeting	target	VBG
cord-032403-9c1xeqg1	30	25	,	,	,
cord-032403-9c1xeqg1	30	26	for	for	IN
cord-032403-9c1xeqg1	30	27	example	example	NN
cord-032403-9c1xeqg1	30	28	,	,	,
cord-032403-9c1xeqg1	30	29	cancer	cancer	NN
cord-032403-9c1xeqg1	30	30	,	,	,
cord-032403-9c1xeqg1	30	31	autoimmune	autoimmune	JJ
cord-032403-9c1xeqg1	30	32	,	,	,
cord-032403-9c1xeqg1	30	33	and	and	CC
cord-032403-9c1xeqg1	30	34	orphan	orphan	NN
cord-032403-9c1xeqg1	30	35	diseases	disease	NNS
cord-032403-9c1xeqg1	30	36	.	.	.
cord-032403-9c1xeqg1	31	1	These	these	DT
cord-032403-9c1xeqg1	31	2	bioprocesses	bioprocesse	NNS
cord-032403-9c1xeqg1	31	3	are	be	VBP
cord-032403-9c1xeqg1	31	4	complicated	complicated	JJ
cord-032403-9c1xeqg1	31	5	to	to	TO
cord-032403-9c1xeqg1	31	6	control	control	VB
cord-032403-9c1xeqg1	31	7	and	and	CC
cord-032403-9c1xeqg1	31	8	require	require	VB
cord-032403-9c1xeqg1	31	9	many	many	JJ
cord-032403-9c1xeqg1	31	10	cycles	cycle	NNS
cord-032403-9c1xeqg1	31	11	of	of	IN
cord-032403-9c1xeqg1	31	12	usually	usually	RB
cord-032403-9c1xeqg1	31	13	quite	quite	RB
cord-032403-9c1xeqg1	31	14	long	long	JJ
cord-032403-9c1xeqg1	31	15	experimental	experimental	JJ
cord-032403-9c1xeqg1	31	16	investigations	investigation	NNS
cord-032403-9c1xeqg1	31	17	.	.	.
cord-032403-9c1xeqg1	32	1	Hence	hence	RB
cord-032403-9c1xeqg1	32	2	,	,	,
cord-032403-9c1xeqg1	32	3	this	this	DT
cord-032403-9c1xeqg1	32	4	industry	industry	NN
cord-032403-9c1xeqg1	32	5	is	be	VBZ
cord-032403-9c1xeqg1	32	6	driven	drive	VBN
cord-032403-9c1xeqg1	32	7	by	by	IN
cord-032403-9c1xeqg1	32	8	two	two	CD
cord-032403-9c1xeqg1	32	9	opposing	oppose	VBG
cord-032403-9c1xeqg1	32	10	objectives	objective	NNS
cord-032403-9c1xeqg1	32	11	:	:	:
cord-032403-9c1xeqg1	32	12	ensuring	ensure	VBG
cord-032403-9c1xeqg1	32	13	high	high	JJ
cord-032403-9c1xeqg1	32	14	drug	drug	NN
cord-032403-9c1xeqg1	32	15	quality	quality	NN
cord-032403-9c1xeqg1	32	16	and	and	CC
cord-032403-9c1xeqg1	32	17	safety	safety	NN
cord-032403-9c1xeqg1	32	18	to	to	IN
cord-032403-9c1xeqg1	32	19	patients	patient	NNS
cord-032403-9c1xeqg1	32	20	,	,	,
cord-032403-9c1xeqg1	32	21	while	while	IN
cord-032403-9c1xeqg1	32	22	competitively	competitively	RB
cord-032403-9c1xeqg1	32	23	reducing	reduce	VBG
cord-032403-9c1xeqg1	32	24	time	time	NN
cord-032403-9c1xeqg1	32	25	to	to	IN
cord-032403-9c1xeqg1	32	26	market	market	NN
cord-032403-9c1xeqg1	32	27	and	and	CC
cord-032403-9c1xeqg1	32	28	process	process	NN
cord-032403-9c1xeqg1	32	29	development	development	NN
cord-032403-9c1xeqg1	32	30	and	and	CC
cord-032403-9c1xeqg1	32	31	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	32	32	costs	cost	NNS
cord-032403-9c1xeqg1	32	33	.	.	.
cord-032403-9c1xeqg1	33	1	9	9	LS
cord-032403-9c1xeqg1	33	2	Hundreds	hundred	NNS
cord-032403-9c1xeqg1	33	3	of	of	IN
cord-032403-9c1xeqg1	33	4	potentially	potentially	RB
cord-032403-9c1xeqg1	33	5	influential	influential	JJ
cord-032403-9c1xeqg1	33	6	factors	factor	NNS
cord-032403-9c1xeqg1	33	7	in	in	IN
cord-032403-9c1xeqg1	33	8	the	the	DT
cord-032403-9c1xeqg1	33	9	production	production	NN
cord-032403-9c1xeqg1	33	10	process	process	NN
cord-032403-9c1xeqg1	33	11	can	can	MD
cord-032403-9c1xeqg1	33	12	be	be	VB
cord-032403-9c1xeqg1	33	13	taken	take	VBN
cord-032403-9c1xeqg1	33	14	into	into	IN
cord-032403-9c1xeqg1	33	15	account	account	NN
cord-032403-9c1xeqg1	33	16	and	and	CC
cord-032403-9c1xeqg1	33	17	many	many	JJ
cord-032403-9c1xeqg1	33	18	tens	ten	NNS
cord-032403-9c1xeqg1	33	19	of	of	IN
cord-032403-9c1xeqg1	33	20	them	-PRON-	PRP
cord-032403-9c1xeqg1	33	21	are	be	VBP
cord-032403-9c1xeqg1	33	22	being	be	VBG
cord-032403-9c1xeqg1	33	23	broadly	broadly	RB
cord-032403-9c1xeqg1	33	24	monitored	monitor	VBN
cord-032403-9c1xeqg1	33	25	and	and	CC
cord-032403-9c1xeqg1	33	26	controlled	control	VBN
cord-032403-9c1xeqg1	33	27	.	.	.
cord-032403-9c1xeqg1	34	1	10	10	CD
cord-032403-9c1xeqg1	35	1	The	the	DT
cord-032403-9c1xeqg1	35	2	main	main	JJ
cord-032403-9c1xeqg1	35	3	engineering	engineering	NN
cord-032403-9c1xeqg1	35	4	challenges	challenge	NNS
cord-032403-9c1xeqg1	36	1	9,11−13	9,11−13	CD
cord-032403-9c1xeqg1	36	2	are	be	VBP
cord-032403-9c1xeqg1	36	3	to	to	IN
cord-032403-9c1xeqg1	36	4	(	(	-LRB-
cord-032403-9c1xeqg1	36	5	1	1	LS
cord-032403-9c1xeqg1	36	6	)	)	-RRB-
cord-032403-9c1xeqg1	36	7	robustly	robustly	RB
cord-032403-9c1xeqg1	36	8	control	control	VB
cord-032403-9c1xeqg1	36	9	the	the	DT
cord-032403-9c1xeqg1	36	10	behavior	behavior	NN
cord-032403-9c1xeqg1	36	11	of	of	IN
cord-032403-9c1xeqg1	36	12	the	the	DT
cord-032403-9c1xeqg1	36	13	living	live	VBG
cord-032403-9c1xeqg1	36	14	organism	organism	NN
cord-032403-9c1xeqg1	36	15	involved	involve	VBN
cord-032403-9c1xeqg1	36	16	in	in	IN
cord-032403-9c1xeqg1	36	17	the	the	DT
cord-032403-9c1xeqg1	36	18	process	process	NN
cord-032403-9c1xeqg1	36	19	,	,	,
cord-032403-9c1xeqg1	36	20	(	(	-LRB-
cord-032403-9c1xeqg1	36	21	2	2	LS
cord-032403-9c1xeqg1	36	22	)	)	-RRB-
cord-032403-9c1xeqg1	36	23	efficiently	efficiently	RB
cord-032403-9c1xeqg1	36	24	align	align	VB
cord-032403-9c1xeqg1	36	25	the	the	DT
cord-032403-9c1xeqg1	36	26	often	often	RB
cord-032403-9c1xeqg1	36	27	heterogeneous	heterogeneous	JJ
cord-032403-9c1xeqg1	36	28	data	datum	NNS
cord-032403-9c1xeqg1	36	29	generated	generate	VBN
cord-032403-9c1xeqg1	36	30	across	across	IN
cord-032403-9c1xeqg1	36	31	different	different	JJ
cord-032403-9c1xeqg1	36	32	process	process	NN
cord-032403-9c1xeqg1	36	33	units	unit	NNS
cord-032403-9c1xeqg1	36	34	and	and	CC
cord-032403-9c1xeqg1	36	35	scales	scale	NNS
cord-032403-9c1xeqg1	36	36	,	,	,
cord-032403-9c1xeqg1	36	37	(	(	-LRB-
cord-032403-9c1xeqg1	36	38	3	3	LS
cord-032403-9c1xeqg1	36	39	)	)	-RRB-
cord-032403-9c1xeqg1	36	40	include	include	VBP
cord-032403-9c1xeqg1	36	41	all	all	DT
cord-032403-9c1xeqg1	36	42	available	available	JJ
cord-032403-9c1xeqg1	36	43	prior	prior	JJ
cord-032403-9c1xeqg1	36	44	know	know	NN
cord-032403-9c1xeqg1	36	45	-	-	HYPH
cord-032403-9c1xeqg1	36	46	how	how	NN
cord-032403-9c1xeqg1	36	47	and	and	CC
cord-032403-9c1xeqg1	36	48	experience	experience	VB
cord-032403-9c1xeqg1	36	49	into	into	IN
cord-032403-9c1xeqg1	36	50	the	the	DT
cord-032403-9c1xeqg1	36	51	decision	decision	NN
cord-032403-9c1xeqg1	36	52	process	process	NN
cord-032403-9c1xeqg1	36	53	,	,	,
cord-032403-9c1xeqg1	36	54	(	(	-LRB-
cord-032403-9c1xeqg1	36	55	4	4	LS
cord-032403-9c1xeqg1	36	56	)	)	-RRB-
cord-032403-9c1xeqg1	36	57	reduce	reduce	VB
cord-032403-9c1xeqg1	36	58	human	human	JJ
cord-032403-9c1xeqg1	36	59	errors	error	NNS
cord-032403-9c1xeqg1	36	60	and	and	CC
cord-032403-9c1xeqg1	36	61	introduced	introduce	VBN
cord-032403-9c1xeqg1	36	62	inconsistency	inconsistency	NN
cord-032403-9c1xeqg1	36	63	,	,	,
cord-032403-9c1xeqg1	36	64	and	and	CC
cord-032403-9c1xeqg1	36	65	(	(	-LRB-
cord-032403-9c1xeqg1	36	66	5	5	LS
cord-032403-9c1xeqg1	36	67	)	)	-RRB-
cord-032403-9c1xeqg1	36	68	enable	enable	VB
cord-032403-9c1xeqg1	36	69	an	an	DT
cord-032403-9c1xeqg1	36	70	automated	automated	JJ
cord-032403-9c1xeqg1	36	71	and	and	CC
cord-032403-9c1xeqg1	36	72	adaptive	adaptive	JJ
cord-032403-9c1xeqg1	36	73	procedure	procedure	NN
cord-032403-9c1xeqg1	36	74	to	to	TO
cord-032403-9c1xeqg1	36	75	assess	assess	VB
cord-032403-9c1xeqg1	36	76	the	the	DT
cord-032403-9c1xeqg1	36	77	critical	critical	JJ
cord-032403-9c1xeqg1	36	78	process	process	NN
cord-032403-9c1xeqg1	36	79	characteristics	characteristic	NNS
cord-032403-9c1xeqg1	36	80	.	.	.
cord-032403-9c1xeqg1	37	1	This	this	DT
cord-032403-9c1xeqg1	37	2	commentary	commentary	NN
cord-032403-9c1xeqg1	37	3	takes	take	VBZ
cord-032403-9c1xeqg1	37	4	the	the	DT
cord-032403-9c1xeqg1	37	5	Covid-19	covid-19	NN
cord-032403-9c1xeqg1	37	6	pandemic	pandemic	NN
cord-032403-9c1xeqg1	37	7	as	as	IN
cord-032403-9c1xeqg1	37	8	an	an	DT
cord-032403-9c1xeqg1	37	9	illustrative	illustrative	JJ
cord-032403-9c1xeqg1	37	10	example	example	NN
cord-032403-9c1xeqg1	37	11	of	of	IN
cord-032403-9c1xeqg1	37	12	decision	decision	NN
cord-032403-9c1xeqg1	37	13	making	make	VBG
cord-032403-9c1xeqg1	37	14	under	under	IN
cord-032403-9c1xeqg1	37	15	uncertainty	uncertainty	NN
cord-032403-9c1xeqg1	37	16	based	base	VBN
cord-032403-9c1xeqg1	37	17	on	on	IN
cord-032403-9c1xeqg1	37	18	a	a	DT
cord-032403-9c1xeqg1	37	19	daily	daily	JJ
cord-032403-9c1xeqg1	37	20	increasing	increase	VBG
cord-032403-9c1xeqg1	37	21	number	number	NN
cord-032403-9c1xeqg1	37	22	of	of	IN
cord-032403-9c1xeqg1	37	23	available	available	JJ
cord-032403-9c1xeqg1	37	24	data	datum	NNS
cord-032403-9c1xeqg1	37	25	and	and	CC
cord-032403-9c1xeqg1	37	26	know	know	NN
cord-032403-9c1xeqg1	37	27	-	-	HYPH
cord-032403-9c1xeqg1	37	28	how	how	NN
cord-032403-9c1xeqg1	37	29	.	.	.
cord-032403-9c1xeqg1	38	1	This	this	DT
cord-032403-9c1xeqg1	38	2	example	example	NN
cord-032403-9c1xeqg1	38	3	will	will	MD
cord-032403-9c1xeqg1	38	4	be	be	VB
cord-032403-9c1xeqg1	38	5	used	use	VBN
cord-032403-9c1xeqg1	38	6	throughout	throughout	IN
cord-032403-9c1xeqg1	38	7	the	the	DT
cord-032403-9c1xeqg1	38	8	commentary	commentary	NN
cord-032403-9c1xeqg1	38	9	to	to	TO
cord-032403-9c1xeqg1	38	10	portray	portray	VB
cord-032403-9c1xeqg1	38	11	the	the	DT
cord-032403-9c1xeqg1	38	12	decision	decision	NN
cord-032403-9c1xeqg1	38	13	making	make	VBG
cord-032403-9c1xeqg1	38	14	challenges	challenge	NNS
cord-032403-9c1xeqg1	38	15	in	in	IN
cord-032403-9c1xeqg1	38	16	the	the	DT
cord-032403-9c1xeqg1	38	17	biopharmaceutical	biopharmaceutical	JJ
cord-032403-9c1xeqg1	38	18	industry	industry	NN
cord-032403-9c1xeqg1	38	19	with	with	IN
cord-032403-9c1xeqg1	38	20	the	the	DT
cord-032403-9c1xeqg1	38	21	key	key	JJ
cord-032403-9c1xeqg1	38	22	goals	goal	NNS
cord-032403-9c1xeqg1	38	23	to	to	TO
cord-032403-9c1xeqg1	38	24	reflect	reflect	VB
cord-032403-9c1xeqg1	38	25	on	on	IN
cord-032403-9c1xeqg1	38	26	the	the	DT
cord-032403-9c1xeqg1	38	27	potential	potential	NN
cord-032403-9c1xeqg1	38	28	of	of	IN
cord-032403-9c1xeqg1	38	29	different	different	JJ
cord-032403-9c1xeqg1	38	30	digital	digital	JJ
cord-032403-9c1xeqg1	38	31	data	datum	NNS
cord-032403-9c1xeqg1	38	32	-	-	HYPH
cord-032403-9c1xeqg1	38	33	and	and	CC
cord-032403-9c1xeqg1	38	34	knowledge	knowledge	NN
cord-032403-9c1xeqg1	38	35	-	-	HYPH
cord-032403-9c1xeqg1	38	36	driven	drive	VBN
cord-032403-9c1xeqg1	38	37	solutions	solution	NNS
cord-032403-9c1xeqg1	38	38	to	to	TO
cord-032403-9c1xeqg1	38	39	support	support	VB
cord-032403-9c1xeqg1	38	40	mastering	master	VBG
cord-032403-9c1xeqg1	38	41	the	the	DT
cord-032403-9c1xeqg1	38	42	path	path	NN
cord-032403-9c1xeqg1	38	43	toward	toward	IN
cord-032403-9c1xeqg1	38	44	the	the	DT
cord-032403-9c1xeqg1	38	45	standards	standard	NNS
cord-032403-9c1xeqg1	38	46	of	of	IN
cord-032403-9c1xeqg1	38	47	industry	industry	NN
cord-032403-9c1xeqg1	38	48	4.0	4.0	CD
cord-032403-9c1xeqg1	38	49	.	.	.
cord-032403-9c1xeqg1	39	1	Complex	complex	JJ
cord-032403-9c1xeqg1	39	2	problems	problem	NNS
cord-032403-9c1xeqg1	39	3	can	can	MD
cord-032403-9c1xeqg1	39	4	be	be	VB
cord-032403-9c1xeqg1	39	5	solved	solve	VBN
cord-032403-9c1xeqg1	39	6	efficiently	efficiently	RB
cord-032403-9c1xeqg1	39	7	through	through	IN
cord-032403-9c1xeqg1	39	8	the	the	DT
cord-032403-9c1xeqg1	39	9	support	support	NN
cord-032403-9c1xeqg1	39	10	of	of	IN
cord-032403-9c1xeqg1	39	11	relevant	relevant	JJ
cord-032403-9c1xeqg1	39	12	data	datum	NNS
cord-032403-9c1xeqg1	39	13	and/or	and/or	CC
cord-032403-9c1xeqg1	39	14	through	through	IN
cord-032403-9c1xeqg1	39	15	sufficient	sufficient	JJ
cord-032403-9c1xeqg1	39	16	experience	experience	NN
cord-032403-9c1xeqg1	39	17	in	in	IN
cord-032403-9c1xeqg1	39	18	dealing	deal	VBG
cord-032403-9c1xeqg1	39	19	with	with	IN
cord-032403-9c1xeqg1	39	20	similar	similar	JJ
cord-032403-9c1xeqg1	39	21	problems	problem	NNS
cord-032403-9c1xeqg1	39	22	.	.	.
cord-032403-9c1xeqg1	40	1	In	in	IN
cord-032403-9c1xeqg1	40	2	both	both	DT
cord-032403-9c1xeqg1	40	3	cases	case	NNS
cord-032403-9c1xeqg1	40	4	,	,	,
cord-032403-9c1xeqg1	40	5	it	-PRON-	PRP
cord-032403-9c1xeqg1	40	6	is	be	VBZ
cord-032403-9c1xeqg1	40	7	essential	essential	JJ
cord-032403-9c1xeqg1	40	8	to	to	TO
cord-032403-9c1xeqg1	40	9	evaluate	evaluate	VB
cord-032403-9c1xeqg1	40	10	how	how	WRB
cord-032403-9c1xeqg1	40	11	close	close	JJ
cord-032403-9c1xeqg1	40	12	prior	prior	JJ
cord-032403-9c1xeqg1	40	13	data	datum	NNS
cord-032403-9c1xeqg1	40	14	and	and	CC
cord-032403-9c1xeqg1	40	15	knowledge	knowledge	NN
cord-032403-9c1xeqg1	40	16	are	be	VBP
cord-032403-9c1xeqg1	40	17	to	to	IN
cord-032403-9c1xeqg1	40	18	the	the	DT
cord-032403-9c1xeqg1	40	19	problem	problem	NN
cord-032403-9c1xeqg1	40	20	to	to	TO
cord-032403-9c1xeqg1	40	21	be	be	VB
cord-032403-9c1xeqg1	40	22	solved	solve	VBN
cord-032403-9c1xeqg1	40	23	and	and	CC
cord-032403-9c1xeqg1	40	24	how	how	WRB
cord-032403-9c1xeqg1	40	25	trustworthy	trustworthy	JJ
cord-032403-9c1xeqg1	40	26	these	these	DT
cord-032403-9c1xeqg1	40	27	are	be	VBP
cord-032403-9c1xeqg1	40	28	.	.	.
cord-032403-9c1xeqg1	41	1	In	in	IN
cord-032403-9c1xeqg1	41	2	the	the	DT
cord-032403-9c1xeqg1	41	3	Covid-19	covid-19	NN
cord-032403-9c1xeqg1	41	4	pandemic	pandemic	NN
cord-032403-9c1xeqg1	41	5	strong	strong	JJ
cord-032403-9c1xeqg1	41	6	biases	bias	NNS
cord-032403-9c1xeqg1	41	7	are	be	VBP
cord-032403-9c1xeqg1	41	8	introduced	introduce	VBN
cord-032403-9c1xeqg1	41	9	on	on	IN
cord-032403-9c1xeqg1	41	10	the	the	DT
cord-032403-9c1xeqg1	41	11	data	datum	NNS
cord-032403-9c1xeqg1	41	12	due	due	IN
cord-032403-9c1xeqg1	41	13	to	to	IN
cord-032403-9c1xeqg1	41	14	the	the	DT
cord-032403-9c1xeqg1	41	15	long	long	JJ
cord-032403-9c1xeqg1	41	16	incubation	incubation	NN
cord-032403-9c1xeqg1	41	17	time	time	NN
cord-032403-9c1xeqg1	41	18	of	of	IN
cord-032403-9c1xeqg1	41	19	the	the	DT
cord-032403-9c1xeqg1	41	20	virus	virus	NN
cord-032403-9c1xeqg1	41	21	resulting	result	VBG
cord-032403-9c1xeqg1	41	22	in	in	IN
cord-032403-9c1xeqg1	41	23	a	a	DT
cord-032403-9c1xeqg1	41	24	delayed	delay	VBN
cord-032403-9c1xeqg1	41	25	symptomatic	symptomatic	JJ
cord-032403-9c1xeqg1	41	26	response	response	NN
cord-032403-9c1xeqg1	41	27	and	and	CC
cord-032403-9c1xeqg1	41	28	appearance	appearance	NN
cord-032403-9c1xeqg1	41	29	in	in	IN
cord-032403-9c1xeqg1	41	30	the	the	DT
cord-032403-9c1xeqg1	41	31	database	database	NN
cord-032403-9c1xeqg1	41	32	,	,	,
cord-032403-9c1xeqg1	41	33	inconsistencies	inconsistency	NNS
cord-032403-9c1xeqg1	41	34	in	in	IN
cord-032403-9c1xeqg1	41	35	the	the	DT
cord-032403-9c1xeqg1	41	36	fatality	fatality	NN
cord-032403-9c1xeqg1	41	37	definitions	definition	NNS
cord-032403-9c1xeqg1	41	38	,	,	,
cord-032403-9c1xeqg1	41	39	and	and	CC
cord-032403-9c1xeqg1	41	40	incomplete	incomplete	JJ
cord-032403-9c1xeqg1	41	41	testing	testing	NN
cord-032403-9c1xeqg1	41	42	across	across	IN
cord-032403-9c1xeqg1	41	43	the	the	DT
cord-032403-9c1xeqg1	41	44	population	population	NN
cord-032403-9c1xeqg1	41	45	,	,	,
cord-032403-9c1xeqg1	41	46	among	among	IN
cord-032403-9c1xeqg1	41	47	others	other	NNS
cord-032403-9c1xeqg1	41	48	.	.	.
cord-032403-9c1xeqg1	42	1	14	14	CD
cord-032403-9c1xeqg1	42	2	,	,	,
cord-032403-9c1xeqg1	42	3	15	15	CD
cord-032403-9c1xeqg1	42	4	This	this	DT
cord-032403-9c1xeqg1	42	5	uncertainty	uncertainty	NN
cord-032403-9c1xeqg1	42	6	is	be	VBZ
cord-032403-9c1xeqg1	42	7	coupled	couple	VBN
cord-032403-9c1xeqg1	42	8	to	to	IN
cord-032403-9c1xeqg1	42	9	a	a	DT
cord-032403-9c1xeqg1	42	10	lack	lack	NN
cord-032403-9c1xeqg1	42	11	of	of	IN
cord-032403-9c1xeqg1	42	12	governmental	governmental	JJ
cord-032403-9c1xeqg1	42	13	and	and	CC
cord-032403-9c1xeqg1	42	14	social	social	JJ
cord-032403-9c1xeqg1	42	15	experience	experience	NN
cord-032403-9c1xeqg1	42	16	of	of	IN
cord-032403-9c1xeqg1	42	17	dealing	deal	VBG
cord-032403-9c1xeqg1	42	18	with	with	IN
cord-032403-9c1xeqg1	42	19	pandemics	pandemic	NNS
cord-032403-9c1xeqg1	42	20	of	of	IN
cord-032403-9c1xeqg1	42	21	such	such	JJ
cord-032403-9c1xeqg1	42	22	broad	broad	JJ
cord-032403-9c1xeqg1	42	23	magnitude	magnitude	NN
cord-032403-9c1xeqg1	42	24	.	.	.
cord-032403-9c1xeqg1	43	1	14	14	CD
cord-032403-9c1xeqg1	44	1	Also	also	RB
cord-032403-9c1xeqg1	44	2	,	,	,
cord-032403-9c1xeqg1	44	3	the	the	DT
cord-032403-9c1xeqg1	44	4	contribution	contribution	NN
cord-032403-9c1xeqg1	44	5	from	from	IN
cord-032403-9c1xeqg1	44	6	the	the	DT
cord-032403-9c1xeqg1	44	7	scientific	scientific	JJ
cord-032403-9c1xeqg1	44	8	community	community	NN
cord-032403-9c1xeqg1	44	9	is	be	VBZ
cord-032403-9c1xeqg1	44	10	yet	yet	RB
cord-032403-9c1xeqg1	44	11	very	very	RB
cord-032403-9c1xeqg1	44	12	heterogeneous	heterogeneous	JJ
cord-032403-9c1xeqg1	44	13	in	in	IN
cord-032403-9c1xeqg1	44	14	focus	focus	NN
cord-032403-9c1xeqg1	44	15	and	and	CC
cord-032403-9c1xeqg1	44	16	suggestions	suggestion	NNS
cord-032403-9c1xeqg1	44	17	.	.	.
cord-032403-9c1xeqg1	45	1	16	16	CD
cord-032403-9c1xeqg1	46	1	Therefore	therefore	RB
cord-032403-9c1xeqg1	46	2	,	,	,
cord-032403-9c1xeqg1	46	3	data	datum	NNS
cord-032403-9c1xeqg1	46	4	is	be	VBZ
cord-032403-9c1xeqg1	46	5	used	use	VBN
cord-032403-9c1xeqg1	46	6	as	as	IN
cord-032403-9c1xeqg1	46	7	relative	relative	JJ
cord-032403-9c1xeqg1	46	8	trending	trend	VBG
cord-032403-9c1xeqg1	46	9	method	method	NN
cord-032403-9c1xeqg1	46	10	,	,	,
cord-032403-9c1xeqg1	46	11	while	while	IN
cord-032403-9c1xeqg1	46	12	experience	experience	NN
cord-032403-9c1xeqg1	46	13	is	be	VBZ
cord-032403-9c1xeqg1	46	14	gradually	gradually	RB
cord-032403-9c1xeqg1	46	15	building	build	VBG
cord-032403-9c1xeqg1	46	16	up	up	RP
cord-032403-9c1xeqg1	46	17	within	within	IN
cord-032403-9c1xeqg1	46	18	and	and	CC
cord-032403-9c1xeqg1	46	19	across	across	IN
cord-032403-9c1xeqg1	46	20	countries	country	NNS
cord-032403-9c1xeqg1	46	21	.	.	.
cord-032403-9c1xeqg1	47	1	In	in	IN
cord-032403-9c1xeqg1	47	2	biopharma	biopharma	NNS
cord-032403-9c1xeqg1	47	3	,	,	,
cord-032403-9c1xeqg1	47	4	the	the	DT
cord-032403-9c1xeqg1	47	5	situation	situation	NN
cord-032403-9c1xeqg1	47	6	is	be	VBZ
cord-032403-9c1xeqg1	47	7	usually	usually	RB
cord-032403-9c1xeqg1	47	8	much	much	RB
cord-032403-9c1xeqg1	47	9	better	well	JJR
cord-032403-9c1xeqg1	47	10	as	as	IN
cord-032403-9c1xeqg1	47	11	there	there	EX
cord-032403-9c1xeqg1	47	12	is	be	VBZ
cord-032403-9c1xeqg1	47	13	less	less	JJR
cord-032403-9c1xeqg1	47	14	uncertainty	uncertainty	NN
cord-032403-9c1xeqg1	47	15	on	on	IN
cord-032403-9c1xeqg1	47	16	the	the	DT
cord-032403-9c1xeqg1	47	17	acquired	acquire	VBN
cord-032403-9c1xeqg1	47	18	data	datum	NNS
cord-032403-9c1xeqg1	47	19	and	and	CC
cord-032403-9c1xeqg1	47	20	available	available	JJ
cord-032403-9c1xeqg1	47	21	prior	prior	JJ
cord-032403-9c1xeqg1	47	22	experience	experience	NN
cord-032403-9c1xeqg1	47	23	on	on	IN
cord-032403-9c1xeqg1	47	24	developing	develop	VBG
cord-032403-9c1xeqg1	47	25	or	or	CC
cord-032403-9c1xeqg1	47	26	operating	operate	VBG
cord-032403-9c1xeqg1	47	27	similar	similar	JJ
cord-032403-9c1xeqg1	47	28	biopharmaceutical	biopharmaceutical	JJ
cord-032403-9c1xeqg1	47	29	processes	process	NNS
cord-032403-9c1xeqg1	47	30	.	.	.
cord-032403-9c1xeqg1	48	1	Nonetheless	nonetheless	RB
cord-032403-9c1xeqg1	48	2	,	,	,
cord-032403-9c1xeqg1	48	3	the	the	DT
cord-032403-9c1xeqg1	48	4	level	level	NN
cord-032403-9c1xeqg1	48	5	of	of	IN
cord-032403-9c1xeqg1	48	6	uncertainty	uncertainty	NN
cord-032403-9c1xeqg1	48	7	can	can	MD
cord-032403-9c1xeqg1	48	8	be	be	VB
cord-032403-9c1xeqg1	48	9	expected	expect	VBN
cord-032403-9c1xeqg1	48	10	considerably	considerably	RB
cord-032403-9c1xeqg1	48	11	larger	large	JJR
cord-032403-9c1xeqg1	48	12	compared	compare	VBN
cord-032403-9c1xeqg1	48	13	to	to	IN
cord-032403-9c1xeqg1	48	14	the	the	DT
cord-032403-9c1xeqg1	48	15	closely	closely	RB
cord-032403-9c1xeqg1	48	16	related	related	JJ
cord-032403-9c1xeqg1	48	17	small	small	JJ
cord-032403-9c1xeqg1	48	18	-	-	HYPH
cord-032403-9c1xeqg1	48	19	molecule	molecule	NN
cord-032403-9c1xeqg1	48	20	pharma	pharma	NNS
cord-032403-9c1xeqg1	48	21	and	and	CC
cord-032403-9c1xeqg1	48	22	general	general	JJ
cord-032403-9c1xeqg1	48	23	chemistry	chemistry	NN
cord-032403-9c1xeqg1	48	24	sectors	sector	NNS
cord-032403-9c1xeqg1	48	25	.	.	.
cord-032403-9c1xeqg1	49	1	Figure	figure	NN
cord-032403-9c1xeqg1	49	2	1	1	CD
cord-032403-9c1xeqg1	49	3	presents	present	VBZ
cord-032403-9c1xeqg1	49	4	the	the	DT
cord-032403-9c1xeqg1	49	5	landscape	landscape	NN
cord-032403-9c1xeqg1	49	6	of	of	IN
cord-032403-9c1xeqg1	49	7	different	different	JJ
cord-032403-9c1xeqg1	49	8	data	datum	NNS
cord-032403-9c1xeqg1	49	9	(	(	-LRB-
cord-032403-9c1xeqg1	49	10	in	in	IN
cord-032403-9c1xeqg1	49	11	red	red	JJ
cord-032403-9c1xeqg1	49	12	)	)	-RRB-
cord-032403-9c1xeqg1	49	13	and	and	CC
cord-032403-9c1xeqg1	49	14	expertise	expertise	NN
cord-032403-9c1xeqg1	49	15	(	(	-LRB-
cord-032403-9c1xeqg1	49	16	in	in	IN
cord-032403-9c1xeqg1	49	17	yellow	yellow	JJ
cord-032403-9c1xeqg1	49	18	)	)	-RRB-
cord-032403-9c1xeqg1	49	19	available	available	JJ
cord-032403-9c1xeqg1	49	20	in	in	IN
cord-032403-9c1xeqg1	49	21	bioprocessing	bioprocesse	VBG
cord-032403-9c1xeqg1	49	22	together	together	RB
cord-032403-9c1xeqg1	49	23	with	with	IN
cord-032403-9c1xeqg1	49	24	the	the	DT
cord-032403-9c1xeqg1	49	25	duration	duration	NN
cord-032403-9c1xeqg1	49	26	to	to	TO
cord-032403-9c1xeqg1	49	27	generate	generate	VB
cord-032403-9c1xeqg1	49	28	these	these	DT
cord-032403-9c1xeqg1	49	29	and	and	CC
cord-032403-9c1xeqg1	49	30	a	a	DT
cord-032403-9c1xeqg1	49	31	tendency	tendency	NN
cord-032403-9c1xeqg1	49	32	of	of	IN
cord-032403-9c1xeqg1	49	33	their	-PRON-	PRP$
cord-032403-9c1xeqg1	49	34	utilization	utilization	NN
cord-032403-9c1xeqg1	49	35	importance	importance	NN
cord-032403-9c1xeqg1	49	36	for	for	IN
cord-032403-9c1xeqg1	49	37	decision	decision	NN
cord-032403-9c1xeqg1	49	38	making	making	NN
cord-032403-9c1xeqg1	49	39	.	.	.
cord-032403-9c1xeqg1	50	1	In	in	IN
cord-032403-9c1xeqg1	50	2	the	the	DT
cord-032403-9c1xeqg1	50	3	very	very	RB
cord-032403-9c1xeqg1	50	4	heterogeneous	heterogeneous	JJ
cord-032403-9c1xeqg1	50	5	field	field	NN
cord-032403-9c1xeqg1	50	6	of	of	IN
cord-032403-9c1xeqg1	50	7	data	datum	NNS
cord-032403-9c1xeqg1	50	8	sources	source	NNS
cord-032403-9c1xeqg1	50	9	in	in	IN
cord-032403-9c1xeqg1	50	10	bioprocessing	bioprocesse	VBG
cord-032403-9c1xeqg1	50	11	one	one	CD
cord-032403-9c1xeqg1	50	12	important	important	JJ
cord-032403-9c1xeqg1	50	13	group	group	NN
cord-032403-9c1xeqg1	50	14	is	be	VBZ
cord-032403-9c1xeqg1	50	15	the	the	DT
cord-032403-9c1xeqg1	50	16	information	information	NN
cord-032403-9c1xeqg1	50	17	defined	define	VBN
cord-032403-9c1xeqg1	50	18	or	or	CC
cord-032403-9c1xeqg1	50	19	available	available	JJ
cord-032403-9c1xeqg1	50	20	before	before	IN
cord-032403-9c1xeqg1	50	21	the	the	DT
cord-032403-9c1xeqg1	50	22	start	start	NN
cord-032403-9c1xeqg1	50	23	of	of	IN
cord-032403-9c1xeqg1	50	24	the	the	DT
cord-032403-9c1xeqg1	50	25	process	process	NN
cord-032403-9c1xeqg1	50	26	(	(	-LRB-
cord-032403-9c1xeqg1	50	27	or	or	CC
cord-032403-9c1xeqg1	50	28	a	a	DT
cord-032403-9c1xeqg1	50	29	certain	certain	JJ
cord-032403-9c1xeqg1	50	30	unit	unit	NN
cord-032403-9c1xeqg1	50	31	operation	operation	NN
cord-032403-9c1xeqg1	50	32	)	)	-RRB-
cord-032403-9c1xeqg1	50	33	such	such	JJ
cord-032403-9c1xeqg1	50	34	as	as	IN
cord-032403-9c1xeqg1	50	35	the	the	DT
cord-032403-9c1xeqg1	50	36	designed	design	VBN
cord-032403-9c1xeqg1	50	37	set	set	NN
cord-032403-9c1xeqg1	50	38	points	point	NNS
cord-032403-9c1xeqg1	50	39	(	(	-LRB-
cord-032403-9c1xeqg1	50	40	experimental	experimental	JJ
cord-032403-9c1xeqg1	50	41	design	design	NN
cord-032403-9c1xeqg1	50	42	in	in	IN
cord-032403-9c1xeqg1	50	43	development	development	NN
cord-032403-9c1xeqg1	50	44	or	or	CC
cord-032403-9c1xeqg1	50	45	process	process	NN
cord-032403-9c1xeqg1	50	46	design	design	NN
cord-032403-9c1xeqg1	50	47	space	space	NN
cord-032403-9c1xeqg1	50	48	in	in	IN
cord-032403-9c1xeqg1	50	49	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	50	50	)	)	-RRB-
cord-032403-9c1xeqg1	50	51	,	,	,
cord-032403-9c1xeqg1	50	52	from	from	IN
cord-032403-9c1xeqg1	50	53	here	here	RB
cord-032403-9c1xeqg1	50	54	on	on	IN
cord-032403-9c1xeqg1	50	55	referred	refer	VBN
cord-032403-9c1xeqg1	50	56	to	to	IN
cord-032403-9c1xeqg1	50	57	as	as	IN
cord-032403-9c1xeqg1	50	58	Z	z	NN
cord-032403-9c1xeqg1	50	59	variables	variable	NNS
cord-032403-9c1xeqg1	50	60	.	.	.
cord-032403-9c1xeqg1	51	1	These	these	DT
cord-032403-9c1xeqg1	51	2	variables	variable	NNS
cord-032403-9c1xeqg1	51	3	are	be	VBP
cord-032403-9c1xeqg1	51	4	essential	essential	JJ
cord-032403-9c1xeqg1	51	5	to	to	TO
cord-032403-9c1xeqg1	51	6	define	define	VB
cord-032403-9c1xeqg1	51	7	an	an	DT
cord-032403-9c1xeqg1	51	8	optimal	optimal	JJ
cord-032403-9c1xeqg1	51	9	and	and	CC
cord-032403-9c1xeqg1	51	10	robust	robust	JJ
cord-032403-9c1xeqg1	51	11	operation	operation	NN
cord-032403-9c1xeqg1	51	12	strategy	strategy	NN
cord-032403-9c1xeqg1	51	13	for	for	IN
cord-032403-9c1xeqg1	51	14	the	the	DT
cord-032403-9c1xeqg1	51	15	process	process	NN
cord-032403-9c1xeqg1	51	16	,	,	,
cord-032403-9c1xeqg1	51	17	whereby	whereby	WRB
cord-032403-9c1xeqg1	51	18	meta	meta	NNP
cord-032403-9c1xeqg1	51	19	data	datum	NNS
cord-032403-9c1xeqg1	51	20	(	(	-LRB-
cord-032403-9c1xeqg1	51	21	e.g.	e.g.	RB
cord-032403-9c1xeqg1	51	22	,	,	,
cord-032403-9c1xeqg1	51	23	information	information	NN
cord-032403-9c1xeqg1	51	24	on	on	IN
cord-032403-9c1xeqg1	51	25	operator	operator	NN
cord-032403-9c1xeqg1	51	26	,	,	,
cord-032403-9c1xeqg1	51	27	devices	device	NNS
cord-032403-9c1xeqg1	51	28	,	,	,
cord-032403-9c1xeqg1	51	29	site	site	NN
cord-032403-9c1xeqg1	51	30	specifications	specification	NNS
cord-032403-9c1xeqg1	51	31	)	)	-RRB-
cord-032403-9c1xeqg1	51	32	and	and	CC
cord-032403-9c1xeqg1	51	33	raw	raw	JJ
cord-032403-9c1xeqg1	51	34	material	material	NN
cord-032403-9c1xeqg1	51	35	information	information	NN
cord-032403-9c1xeqg1	51	36	are	be	VBP
cord-032403-9c1xeqg1	51	37	often	often	RB
cord-032403-9c1xeqg1	51	38	taken	take	VBN
cord-032403-9c1xeqg1	51	39	into	into	IN
cord-032403-9c1xeqg1	51	40	account	account	NN
cord-032403-9c1xeqg1	51	41	significantly	significantly	RB
cord-032403-9c1xeqg1	51	42	less	less	RBR
cord-032403-9c1xeqg1	51	43	compared	compare	VBN
cord-032403-9c1xeqg1	51	44	to	to	IN
cord-032403-9c1xeqg1	51	45	the	the	DT
cord-032403-9c1xeqg1	51	46	other	other	JJ
cord-032403-9c1xeqg1	51	47	variables	variable	NNS
cord-032403-9c1xeqg1	51	48	.	.	.
cord-032403-9c1xeqg1	52	1	The	the	DT
cord-032403-9c1xeqg1	52	2	variables	variable	NNS
cord-032403-9c1xeqg1	52	3	labeled	label	VBN
cord-032403-9c1xeqg1	52	4	with	with	IN
cord-032403-9c1xeqg1	52	5	a	a	DT
cord-032403-9c1xeqg1	52	6	preceding	precede	VBG
cord-032403-9c1xeqg1	52	7	X	x	NN
cord-032403-9c1xeqg1	52	8	are	be	VBP
cord-032403-9c1xeqg1	52	9	dynamic	dynamic	JJ
cord-032403-9c1xeqg1	52	10	process	process	NN
cord-032403-9c1xeqg1	52	11	measurements	measurement	NNS
cord-032403-9c1xeqg1	52	12	through	through	IN
cord-032403-9c1xeqg1	52	13	different	different	JJ
cord-032403-9c1xeqg1	52	14	sensors	sensor	NNS
cord-032403-9c1xeqg1	52	15	(	(	-LRB-
cord-032403-9c1xeqg1	52	16	online	online	JJ
cord-032403-9c1xeqg1	52	17	)	)	-RRB-
cord-032403-9c1xeqg1	52	18	or	or	CC
cord-032403-9c1xeqg1	52	19	offline	offline	JJ
cord-032403-9c1xeqg1	52	20	analytics	analytic	NNS
cord-032403-9c1xeqg1	52	21	.	.	.
cord-032403-9c1xeqg1	53	1	These	these	DT
cord-032403-9c1xeqg1	53	2	are	be	VBP
cord-032403-9c1xeqg1	53	3	essential	essential	JJ
cord-032403-9c1xeqg1	53	4	to	to	TO
cord-032403-9c1xeqg1	53	5	monitor	monitor	VB
cord-032403-9c1xeqg1	53	6	the	the	DT
cord-032403-9c1xeqg1	53	7	process	process	NN
cord-032403-9c1xeqg1	53	8	and	and	CC
cord-032403-9c1xeqg1	53	9	provide	provide	VB
cord-032403-9c1xeqg1	53	10	a	a	DT
cord-032403-9c1xeqg1	53	11	basis	basis	NN
cord-032403-9c1xeqg1	53	12	for	for	IN
cord-032403-9c1xeqg1	53	13	control	control	NN
cord-032403-9c1xeqg1	53	14	.	.	.
cord-032403-9c1xeqg1	54	1	Unlike	unlike	IN
cord-032403-9c1xeqg1	54	2	variable	variable	JJ
cord-032403-9c1xeqg1	54	3	-	-	HYPH
cord-032403-9c1xeqg1	54	4	specific	specific	JJ
cord-032403-9c1xeqg1	54	5	sensors	sensor	NNS
cord-032403-9c1xeqg1	54	6	such	such	JJ
cord-032403-9c1xeqg1	54	7	as	as	IN
cord-032403-9c1xeqg1	54	8	pH	pH	NNP
cord-032403-9c1xeqg1	54	9	,	,	,
cord-032403-9c1xeqg1	54	10	information	information	NN
cord-032403-9c1xeqg1	54	11	from	from	IN
cord-032403-9c1xeqg1	54	12	spectroscopes	spectroscopes	NNP
cord-032403-9c1xeqg1	54	13	(	(	-LRB-
cord-032403-9c1xeqg1	54	14	e.g.	e.g.	RB
cord-032403-9c1xeqg1	54	15	,	,	,
cord-032403-9c1xeqg1	54	16	Raman	Raman	NNP
cord-032403-9c1xeqg1	54	17	or	or	CC
cord-032403-9c1xeqg1	54	18	NIR	NIR	NNP
cord-032403-9c1xeqg1	54	19	)	)	-RRB-
cord-032403-9c1xeqg1	54	20	has	have	VBZ
cord-032403-9c1xeqg1	54	21	to	to	TO
cord-032403-9c1xeqg1	54	22	be	be	VB
cord-032403-9c1xeqg1	54	23	linked	link	VBN
cord-032403-9c1xeqg1	54	24	to	to	IN
cord-032403-9c1xeqg1	54	25	the	the	DT
cord-032403-9c1xeqg1	54	26	variable	variable	NN
cord-032403-9c1xeqg1	54	27	of	of	IN
cord-032403-9c1xeqg1	54	28	interest	interest	NN
cord-032403-9c1xeqg1	54	29	through	through	IN
cord-032403-9c1xeqg1	54	30	a	a	DT
cord-032403-9c1xeqg1	54	31	regression	regression	NN
cord-032403-9c1xeqg1	54	32	method	method	NN
cord-032403-9c1xeqg1	54	33	,	,	,
cord-032403-9c1xeqg1	54	34	which	which	WDT
cord-032403-9c1xeqg1	54	35	requires	require	VBZ
cord-032403-9c1xeqg1	54	36	additional	additional	JJ
cord-032403-9c1xeqg1	54	37	work	work	NN
cord-032403-9c1xeqg1	54	38	to	to	TO
cord-032403-9c1xeqg1	54	39	be	be	VB
cord-032403-9c1xeqg1	54	40	calibrated	calibrate	VBN
cord-032403-9c1xeqg1	54	41	.	.	.
cord-032403-9c1xeqg1	55	1	In	in	IN
cord-032403-9c1xeqg1	55	2	particular	particular	JJ
cord-032403-9c1xeqg1	55	3	,	,	,
cord-032403-9c1xeqg1	55	4	the	the	DT
cord-032403-9c1xeqg1	55	5	profiles	profile	NNS
cord-032403-9c1xeqg1	55	6	of	of	IN
cord-032403-9c1xeqg1	55	7	selected	select	VBN
cord-032403-9c1xeqg1	55	8	characteristic	characteristic	JJ
cord-032403-9c1xeqg1	55	9	variables	variable	NNS
cord-032403-9c1xeqg1	55	10	for	for	IN
cord-032403-9c1xeqg1	55	11	each	each	DT
cord-032403-9c1xeqg1	55	12	unit	unit	NN
cord-032403-9c1xeqg1	55	13	operation	operation	NN
cord-032403-9c1xeqg1	55	14	are	be	VBP
cord-032403-9c1xeqg1	55	15	always	always	RB
cord-032403-9c1xeqg1	55	16	considered	consider	VBN
cord-032403-9c1xeqg1	55	17	in	in	IN
cord-032403-9c1xeqg1	55	18	the	the	DT
cord-032403-9c1xeqg1	55	19	decision	decision	NN
cord-032403-9c1xeqg1	55	20	process	process	NN
cord-032403-9c1xeqg1	55	21	,	,	,
cord-032403-9c1xeqg1	55	22	while	while	IN
cord-032403-9c1xeqg1	55	23	the	the	DT
cord-032403-9c1xeqg1	55	24	inclusion	inclusion	NN
cord-032403-9c1xeqg1	55	25	of	of	IN
cord-032403-9c1xeqg1	55	26	all	all	DT
cord-032403-9c1xeqg1	55	27	other	other	JJ
cord-032403-9c1xeqg1	55	28	sensor	sensor	NN
cord-032403-9c1xeqg1	55	29	data	data	NN
cord-032403-9c1xeqg1	55	30	depends	depend	VBZ
cord-032403-9c1xeqg1	55	31	on	on	IN
cord-032403-9c1xeqg1	55	32	its	-PRON-	PRP$
cord-032403-9c1xeqg1	55	33	importance	importance	NN
cord-032403-9c1xeqg1	55	34	for	for	IN
cord-032403-9c1xeqg1	55	35	process	process	NN
cord-032403-9c1xeqg1	55	36	control	control	NN
cord-032403-9c1xeqg1	55	37	and	and	CC
cord-032403-9c1xeqg1	55	38	direct	direct	JJ
cord-032403-9c1xeqg1	55	39	availability	availability	NN
cord-032403-9c1xeqg1	55	40	from	from	IN
cord-032403-9c1xeqg1	55	41	the	the	DT
cord-032403-9c1xeqg1	55	42	historian	historian	NN
cord-032403-9c1xeqg1	55	43	,	,	,
cord-032403-9c1xeqg1	55	44	that	that	RB
cord-032403-9c1xeqg1	55	45	is	is	RB
cord-032403-9c1xeqg1	55	46	,	,	,
cord-032403-9c1xeqg1	55	47	the	the	DT
cord-032403-9c1xeqg1	55	48	possibility	possibility	NN
cord-032403-9c1xeqg1	55	49	to	to	TO
cord-032403-9c1xeqg1	55	50	directly	directly	RB
cord-032403-9c1xeqg1	55	51	align	align	VB
cord-032403-9c1xeqg1	55	52	all	all	DT
cord-032403-9c1xeqg1	55	53	available	available	JJ
cord-032403-9c1xeqg1	55	54	dynamic	dynamic	JJ
cord-032403-9c1xeqg1	55	55	data	datum	NNS
cord-032403-9c1xeqg1	55	56	sources	source	NNS
cord-032403-9c1xeqg1	55	57	,	,	,
cord-032403-9c1xeqg1	55	58	which	which	WDT
cord-032403-9c1xeqg1	55	59	often	often	RB
cord-032403-9c1xeqg1	55	60	is	be	VBZ
cord-032403-9c1xeqg1	55	61	not	not	RB
cord-032403-9c1xeqg1	55	62	the	the	DT
cord-032403-9c1xeqg1	55	63	case	case	NN
cord-032403-9c1xeqg1	55	64	.	.	.
cord-032403-9c1xeqg1	56	1	Finally	finally	RB
cord-032403-9c1xeqg1	56	2	,	,	,
cord-032403-9c1xeqg1	56	3	the	the	DT
cord-032403-9c1xeqg1	56	4	variables	variable	NNS
cord-032403-9c1xeqg1	56	5	quantifying	quantify	VBG
cord-032403-9c1xeqg1	56	6	the	the	DT
cord-032403-9c1xeqg1	56	7	product	product	NN
cord-032403-9c1xeqg1	56	8	quality	quality	NN
cord-032403-9c1xeqg1	56	9	are	be	VBP
cord-032403-9c1xeqg1	56	10	labeled	label	VBN
cord-032403-9c1xeqg1	56	11	with	with	IN
cord-032403-9c1xeqg1	56	12	a	a	DT
cord-032403-9c1xeqg1	56	13	Y	Y	NNP
cord-032403-9c1xeqg1	56	14	symbol	symbol	NN
cord-032403-9c1xeqg1	56	15	.	.	.
cord-032403-9c1xeqg1	57	1	These	these	DT
cord-032403-9c1xeqg1	57	2	are	be	VBP
cord-032403-9c1xeqg1	57	3	essential	essential	JJ
cord-032403-9c1xeqg1	57	4	to	to	TO
cord-032403-9c1xeqg1	57	5	characterize	characterize	VB
cord-032403-9c1xeqg1	57	6	the	the	DT
cord-032403-9c1xeqg1	57	7	process	process	NN
cord-032403-9c1xeqg1	57	8	outcome	outcome	NN
cord-032403-9c1xeqg1	57	9	and	and	CC
cord-032403-9c1xeqg1	57	10	interconnect	interconnect	VB
cord-032403-9c1xeqg1	57	11	different	different	JJ
cord-032403-9c1xeqg1	57	12	unit	unit	NN
cord-032403-9c1xeqg1	57	13	operations	operation	NNS
cord-032403-9c1xeqg1	57	14	,	,	,
cord-032403-9c1xeqg1	57	15	for	for	IN
cord-032403-9c1xeqg1	57	16	example	example	NN
cord-032403-9c1xeqg1	57	17	,	,	,
cord-032403-9c1xeqg1	57	18	the	the	DT
cord-032403-9c1xeqg1	57	19	impurities	impurity	NNS
cord-032403-9c1xeqg1	57	20	produced	produce	VBN
cord-032403-9c1xeqg1	57	21	upstream	upstream	RB
cord-032403-9c1xeqg1	57	22	in	in	IN
cord-032403-9c1xeqg1	57	23	the	the	DT
cord-032403-9c1xeqg1	57	24	bioreactor	bioreactor	NN
cord-032403-9c1xeqg1	57	25	to	to	IN
cord-032403-9c1xeqg1	57	26	the	the	DT
cord-032403-9c1xeqg1	57	27	purification	purification	NN
cord-032403-9c1xeqg1	57	28	procedure	procedure	NN
cord-032403-9c1xeqg1	57	29	in	in	IN
cord-032403-9c1xeqg1	57	30	the	the	DT
cord-032403-9c1xeqg1	57	31	following	follow	VBG
cord-032403-9c1xeqg1	57	32	downstream	downstream	JJ
cord-032403-9c1xeqg1	57	33	operations	operation	NNS
cord-032403-9c1xeqg1	57	34	.	.	.
cord-032403-9c1xeqg1	58	1	These	these	DT
cord-032403-9c1xeqg1	58	2	variables	variable	NNS
cord-032403-9c1xeqg1	58	3	often	often	RB
cord-032403-9c1xeqg1	58	4	require	require	VBP
cord-032403-9c1xeqg1	58	5	a	a	DT
cord-032403-9c1xeqg1	58	6	complex	complex	JJ
cord-032403-9c1xeqg1	58	7	analytical	analytical	JJ
cord-032403-9c1xeqg1	58	8	procedure	procedure	NN
cord-032403-9c1xeqg1	58	9	over	over	IN
cord-032403-9c1xeqg1	58	10	many	many	JJ
cord-032403-9c1xeqg1	58	11	hours	hour	NNS
cord-032403-9c1xeqg1	58	12	to	to	IN
cord-032403-9c1xeqg1	58	13	days	day	NNS
cord-032403-9c1xeqg1	58	14	.	.	.
cord-032403-9c1xeqg1	59	1	Eventually	eventually	RB
cord-032403-9c1xeqg1	59	2	,	,	,
cord-032403-9c1xeqg1	59	3	after	after	IN
cord-032403-9c1xeqg1	59	4	many	many	JJ
cord-032403-9c1xeqg1	59	5	days	day	NNS
cord-032403-9c1xeqg1	59	6	to	to	IN
cord-032403-9c1xeqg1	59	7	few	few	JJ
cord-032403-9c1xeqg1	59	8	weeks	week	NNS
cord-032403-9c1xeqg1	59	9	,	,	,
cord-032403-9c1xeqg1	59	10	the	the	DT
cord-032403-9c1xeqg1	59	11	first	first	JJ
cord-032403-9c1xeqg1	59	12	data	data	NN
cord-032403-9c1xeqg1	59	13	sets	set	NNS
cord-032403-9c1xeqg1	59	14	can	can	MD
cord-032403-9c1xeqg1	59	15	be	be	VB
cord-032403-9c1xeqg1	59	16	obtained	obtain	VBN
cord-032403-9c1xeqg1	59	17	for	for	IN
cord-032403-9c1xeqg1	59	18	a	a	DT
cord-032403-9c1xeqg1	59	19	unit	unit	NN
cord-032403-9c1xeqg1	59	20	operation	operation	NN
cord-032403-9c1xeqg1	59	21	and	and	CC
cord-032403-9c1xeqg1	59	22	,	,	,
cord-032403-9c1xeqg1	59	23	within	within	IN
cord-032403-9c1xeqg1	59	24	months	month	NNS
cord-032403-9c1xeqg1	59	25	,	,	,
cord-032403-9c1xeqg1	59	26	also	also	RB
cord-032403-9c1xeqg1	59	27	the	the	DT
cord-032403-9c1xeqg1	59	28	information	information	NN
cord-032403-9c1xeqg1	59	29	on	on	IN
cord-032403-9c1xeqg1	59	30	several	several	JJ
cord-032403-9c1xeqg1	59	31	development	development	NN
cord-032403-9c1xeqg1	59	32	cycles	cycle	NNS
cord-032403-9c1xeqg1	59	33	as	as	RB
cord-032403-9c1xeqg1	59	34	well	well	RB
cord-032403-9c1xeqg1	59	35	as	as	IN
cord-032403-9c1xeqg1	59	36	several	several	JJ
cord-032403-9c1xeqg1	59	37	unit	unit	NN
cord-032403-9c1xeqg1	59	38	operations	operation	NNS
cord-032403-9c1xeqg1	59	39	can	can	MD
cord-032403-9c1xeqg1	59	40	be	be	VB
cord-032403-9c1xeqg1	59	41	available	available	JJ
cord-032403-9c1xeqg1	59	42	.	.	.
cord-032403-9c1xeqg1	60	1	After	after	IN
cord-032403-9c1xeqg1	60	2	many	many	JJ
cord-032403-9c1xeqg1	60	3	months	month	NNS
cord-032403-9c1xeqg1	60	4	to	to	IN
cord-032403-9c1xeqg1	60	5	several	several	JJ
cord-032403-9c1xeqg1	60	6	years	year	NNS
cord-032403-9c1xeqg1	60	7	,	,	,
cord-032403-9c1xeqg1	60	8	a	a	DT
cord-032403-9c1xeqg1	60	9	complete	complete	JJ
cord-032403-9c1xeqg1	60	10	development	development	NN
cord-032403-9c1xeqg1	60	11	activity	activity	NN
cord-032403-9c1xeqg1	60	12	toward	toward	IN
cord-032403-9c1xeqg1	60	13	the	the	DT
cord-032403-9c1xeqg1	60	14	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	60	15	scale	scale	NN
cord-032403-9c1xeqg1	60	16	can	can	MD
cord-032403-9c1xeqg1	60	17	be	be	VB
cord-032403-9c1xeqg1	60	18	obtained	obtain	VBN
cord-032403-9c1xeqg1	60	19	.	.	.
cord-032403-9c1xeqg1	61	1	In	in	IN
cord-032403-9c1xeqg1	61	2	development	development	NN
cord-032403-9c1xeqg1	61	3	and	and	CC
cord-032403-9c1xeqg1	61	4	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	61	5	,	,	,
cord-032403-9c1xeqg1	61	6	many	many	JJ
cord-032403-9c1xeqg1	61	7	professionals	professional	NNS
cord-032403-9c1xeqg1	61	8	are	be	VBP
cord-032403-9c1xeqg1	61	9	involved	involve	VBN
cord-032403-9c1xeqg1	61	10	,	,	,
cord-032403-9c1xeqg1	61	11	who	who	WP
cord-032403-9c1xeqg1	61	12	had	have	VBD
cord-032403-9c1xeqg1	61	13	to	to	TO
cord-032403-9c1xeqg1	61	14	go	go	VB
cord-032403-9c1xeqg1	61	15	through	through	IN
cord-032403-9c1xeqg1	61	16	a	a	DT
cord-032403-9c1xeqg1	61	17	long	long	JJ
cord-032403-9c1xeqg1	61	18	learning	learning	NN
cord-032403-9c1xeqg1	61	19	procedure	procedure	NN
cord-032403-9c1xeqg1	61	20	of	of	IN
cord-032403-9c1xeqg1	61	21	hands	hand	NNS
cord-032403-9c1xeqg1	61	22	-	-	HYPH
cord-032403-9c1xeqg1	61	23	on	on	RP
cord-032403-9c1xeqg1	61	24	experience	experience	NN
cord-032403-9c1xeqg1	61	25	in	in	IN
cord-032403-9c1xeqg1	61	26	the	the	DT
cord-032403-9c1xeqg1	61	27	lab	lab	NN
cord-032403-9c1xeqg1	61	28	,	,	,
cord-032403-9c1xeqg1	61	29	working	work	VBG
cord-032403-9c1xeqg1	61	30	on	on	IN
cord-032403-9c1xeqg1	61	31	multiple	multiple	JJ
cord-032403-9c1xeqg1	61	32	scales	scale	NNS
cord-032403-9c1xeqg1	61	33	and	and	CC
cord-032403-9c1xeqg1	61	34	for	for	IN
cord-032403-9c1xeqg1	61	35	the	the	DT
cord-032403-9c1xeqg1	61	36	production	production	NN
cord-032403-9c1xeqg1	61	37	of	of	IN
cord-032403-9c1xeqg1	61	38	different	different	JJ
cord-032403-9c1xeqg1	61	39	molecules	molecule	NNS
cord-032403-9c1xeqg1	61	40	,	,	,
cord-032403-9c1xeqg1	61	41	possibly	possibly	RB
cord-032403-9c1xeqg1	61	42	utilizing	utilize	VBG
cord-032403-9c1xeqg1	61	43	different	different	JJ
cord-032403-9c1xeqg1	61	44	biological	biological	JJ
cord-032403-9c1xeqg1	61	45	organisms	organism	NNS
cord-032403-9c1xeqg1	61	46	,	,	,
cord-032403-9c1xeqg1	61	47	operation	operation	NN
cord-032403-9c1xeqg1	61	48	strategies	strategy	NNS
cord-032403-9c1xeqg1	61	49	and	and	CC
cord-032403-9c1xeqg1	61	50	devices	device	NNS
cord-032403-9c1xeqg1	61	51	.	.	.
cord-032403-9c1xeqg1	62	1	Such	such	JJ
cord-032403-9c1xeqg1	62	2	expertise	expertise	NN
cord-032403-9c1xeqg1	62	3	for	for	IN
cord-032403-9c1xeqg1	62	4	the	the	DT
cord-032403-9c1xeqg1	62	5	complex	complex	JJ
cord-032403-9c1xeqg1	62	6	underlying	underlying	JJ
cord-032403-9c1xeqg1	62	7	processes	process	NNS
cord-032403-9c1xeqg1	62	8	is	be	VBZ
cord-032403-9c1xeqg1	62	9	built	build	VBN
cord-032403-9c1xeqg1	62	10	throughout	throughout	IN
cord-032403-9c1xeqg1	62	11	several	several	JJ
cord-032403-9c1xeqg1	62	12	years	year	NNS
cord-032403-9c1xeqg1	62	13	.	.	.
cord-032403-9c1xeqg1	63	1	Similarly	similarly	RB
cord-032403-9c1xeqg1	63	2	,	,	,
cord-032403-9c1xeqg1	63	3	also	also	RB
cord-032403-9c1xeqg1	63	4	the	the	DT
cord-032403-9c1xeqg1	63	5	modeling	modeling	NN
cord-032403-9c1xeqg1	63	6	experts	expert	NNS
cord-032403-9c1xeqg1	63	7	capable	capable	JJ
cord-032403-9c1xeqg1	63	8	of	of	IN
cord-032403-9c1xeqg1	63	9	formalizing	formalize	VBG
cord-032403-9c1xeqg1	63	10	certain	certain	JJ
cord-032403-9c1xeqg1	63	11	mechanistic	mechanistic	JJ
cord-032403-9c1xeqg1	63	12	process	process	NN
cord-032403-9c1xeqg1	63	13	behavior	behavior	NN
cord-032403-9c1xeqg1	63	14	and/or	and/or	CC
cord-032403-9c1xeqg1	63	15	statistically	statistically	RB
cord-032403-9c1xeqg1	63	16	deriving	derive	VBG
cord-032403-9c1xeqg1	63	17	process	process	NN
cord-032403-9c1xeqg1	63	18	interrelationships	interrelationship	NNS
cord-032403-9c1xeqg1	63	19	(	(	-LRB-
cord-032403-9c1xeqg1	63	20	chemometrics	chemometric	NNS
cord-032403-9c1xeqg1	63	21	)	)	-RRB-
cord-032403-9c1xeqg1	63	22	require	require	VBP
cord-032403-9c1xeqg1	63	23	training	training	NN
cord-032403-9c1xeqg1	63	24	of	of	IN
cord-032403-9c1xeqg1	63	25	many	many	JJ
cord-032403-9c1xeqg1	63	26	months	month	NNS
cord-032403-9c1xeqg1	63	27	to	to	IN
cord-032403-9c1xeqg1	63	28	a	a	DT
cord-032403-9c1xeqg1	63	29	few	few	JJ
cord-032403-9c1xeqg1	63	30	years	year	NNS
cord-032403-9c1xeqg1	63	31	,	,	,
cord-032403-9c1xeqg1	63	32	with	with	IN
cord-032403-9c1xeqg1	63	33	the	the	DT
cord-032403-9c1xeqg1	63	34	generation	generation	NN
cord-032403-9c1xeqg1	63	35	of	of	IN
cord-032403-9c1xeqg1	63	36	a	a	DT
cord-032403-9c1xeqg1	63	37	new	new	JJ
cord-032403-9c1xeqg1	63	38	predictive	predictive	JJ
cord-032403-9c1xeqg1	63	39	model	model	NN
cord-032403-9c1xeqg1	63	40	potentially	potentially	RB
cord-032403-9c1xeqg1	63	41	lasting	last	VBG
cord-032403-9c1xeqg1	63	42	for	for	IN
cord-032403-9c1xeqg1	63	43	several	several	JJ
cord-032403-9c1xeqg1	63	44	months	month	NNS
cord-032403-9c1xeqg1	63	45	.	.	.
cord-032403-9c1xeqg1	64	1	All	all	DT
cord-032403-9c1xeqg1	64	2	such	such	JJ
cord-032403-9c1xeqg1	64	3	expertise	expertise	NN
cord-032403-9c1xeqg1	64	4	is	be	VBZ
cord-032403-9c1xeqg1	64	5	usually	usually	RB
cord-032403-9c1xeqg1	64	6	linked	link	VBN
cord-032403-9c1xeqg1	64	7	to	to	IN
cord-032403-9c1xeqg1	64	8	individuals	individual	NNS
cord-032403-9c1xeqg1	64	9	and	and	CC
cord-032403-9c1xeqg1	64	10	is	be	VBZ
cord-032403-9c1xeqg1	64	11	not	not	RB
cord-032403-9c1xeqg1	64	12	available	available	JJ
cord-032403-9c1xeqg1	64	13	in	in	IN
cord-032403-9c1xeqg1	64	14	a	a	DT
cord-032403-9c1xeqg1	64	15	generalized	generalized	JJ
cord-032403-9c1xeqg1	64	16	format	format	NN
cord-032403-9c1xeqg1	64	17	to	to	IN
cord-032403-9c1xeqg1	64	18	other	other	JJ
cord-032403-9c1xeqg1	64	19	team	team	NN
cord-032403-9c1xeqg1	64	20	members	member	NNS
cord-032403-9c1xeqg1	64	21	.	.	.
cord-032403-9c1xeqg1	65	1	Because	because	IN
cord-032403-9c1xeqg1	65	2	of	of	IN
cord-032403-9c1xeqg1	65	3	significant	significant	JJ
cord-032403-9c1xeqg1	65	4	time	time	NN
cord-032403-9c1xeqg1	65	5	pressure	pressure	NN
cord-032403-9c1xeqg1	65	6	in	in	IN
cord-032403-9c1xeqg1	65	7	development	development	NN
cord-032403-9c1xeqg1	65	8	and	and	CC
cord-032403-9c1xeqg1	65	9	risk	risk	NN
cord-032403-9c1xeqg1	65	10	mitigation	mitigation	NN
cord-032403-9c1xeqg1	65	11	pressure	pressure	NN
cord-032403-9c1xeqg1	65	12	in	in	IN
cord-032403-9c1xeqg1	65	13	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	65	14	,	,	,
cord-032403-9c1xeqg1	65	15	decisions	decision	NNS
cord-032403-9c1xeqg1	65	16	are	be	VBP
cord-032403-9c1xeqg1	65	17	often	often	RB
cord-032403-9c1xeqg1	65	18	made	make	VBN
cord-032403-9c1xeqg1	65	19	on	on	IN
cord-032403-9c1xeqg1	65	20	an	an	DT
cord-032403-9c1xeqg1	65	21	ad	ad	FW
cord-032403-9c1xeqg1	65	22	hoc	hoc	FW
cord-032403-9c1xeqg1	65	23	basis	basis	NN
cord-032403-9c1xeqg1	65	24	involving	involve	VBG
cord-032403-9c1xeqg1	65	25	expert	expert	NN
cord-032403-9c1xeqg1	65	26	meetings	meeting	NNS
cord-032403-9c1xeqg1	65	27	where	where	WRB
cord-032403-9c1xeqg1	65	28	all	all	DT
cord-032403-9c1xeqg1	65	29	readily	readily	RB
cord-032403-9c1xeqg1	65	30	available	available	JJ
cord-032403-9c1xeqg1	65	31	data	datum	NNS
cord-032403-9c1xeqg1	65	32	,	,	,
cord-032403-9c1xeqg1	65	33	analysis	analysis	NN
cord-032403-9c1xeqg1	65	34	results	result	NNS
cord-032403-9c1xeqg1	65	35	,	,	,
cord-032403-9c1xeqg1	65	36	and	and	CC
cord-032403-9c1xeqg1	65	37	experience	experience	NN
cord-032403-9c1xeqg1	65	38	sources	source	NNS
cord-032403-9c1xeqg1	65	39	are	be	VBP
cord-032403-9c1xeqg1	65	40	taken	take	VBN
cord-032403-9c1xeqg1	65	41	into	into	IN
cord-032403-9c1xeqg1	65	42	account	account	NN
cord-032403-9c1xeqg1	65	43	without	without	IN
cord-032403-9c1xeqg1	65	44	ensuring	ensure	VBG
cord-032403-9c1xeqg1	65	45	consideration	consideration	NN
cord-032403-9c1xeqg1	65	46	of	of	IN
cord-032403-9c1xeqg1	65	47	all	all	DT
cord-032403-9c1xeqg1	65	48	possible	possible	JJ
cord-032403-9c1xeqg1	65	49	available	available	JJ
cord-032403-9c1xeqg1	65	50	information	information	NN
cord-032403-9c1xeqg1	65	51	hidden	hide	VBN
cord-032403-9c1xeqg1	65	52	in	in	IN
cord-032403-9c1xeqg1	65	53	the	the	DT
cord-032403-9c1xeqg1	65	54	databases	database	NNS
cord-032403-9c1xeqg1	65	55	or	or	CC
cord-032403-9c1xeqg1	65	56	inside	inside	IN
cord-032403-9c1xeqg1	65	57	the	the	DT
cord-032403-9c1xeqg1	65	58	potential	potential	NN
cord-032403-9c1xeqg1	65	59	of	of	IN
cord-032403-9c1xeqg1	65	60	(	(	-LRB-
cord-032403-9c1xeqg1	65	61	not	not	RB
cord-032403-9c1xeqg1	65	62	automatedly	automatedly	RB
cord-032403-9c1xeqg1	65	63	retrained	retrain	VBN
cord-032403-9c1xeqg1	65	64	or	or	CC
cord-032403-9c1xeqg1	65	65	connected	connect	VBN
cord-032403-9c1xeqg1	65	66	)	)	-RRB-
cord-032403-9c1xeqg1	65	67	predictive	predictive	JJ
cord-032403-9c1xeqg1	65	68	models	model	NNS
cord-032403-9c1xeqg1	65	69	.	.	.
cord-032403-9c1xeqg1	65	70	 	 	_SP
cord-032403-9c1xeqg1	66	1	Hybrid	hybrid	NN
cord-032403-9c1xeqg1	66	2	modeling	modeling	NN
cord-032403-9c1xeqg1	66	3	pursues	pursue	VBZ
cord-032403-9c1xeqg1	66	4	the	the	DT
cord-032403-9c1xeqg1	66	5	goal	goal	NN
cord-032403-9c1xeqg1	66	6	to	to	TO
cord-032403-9c1xeqg1	66	7	synergistically	synergistically	RB
cord-032403-9c1xeqg1	66	8	combine	combine	VB
cord-032403-9c1xeqg1	66	9	available	available	JJ
cord-032403-9c1xeqg1	66	10	data	datum	NNS
cord-032403-9c1xeqg1	66	11	and	and	CC
cord-032403-9c1xeqg1	66	12	know	know	NN
cord-032403-9c1xeqg1	66	13	-	-	HYPH
cord-032403-9c1xeqg1	66	14	how	how	NN
cord-032403-9c1xeqg1	66	15	as	as	IN
cord-032403-9c1xeqg1	66	16	highlighted	highlight	VBN
cord-032403-9c1xeqg1	66	17	in	in	IN
cord-032403-9c1xeqg1	66	18	the	the	DT
cord-032403-9c1xeqg1	66	19	graphical	graphical	JJ
cord-032403-9c1xeqg1	66	20	abstract	abstract	JJ
cord-032403-9c1xeqg1	66	21	figure	figure	NN
cord-032403-9c1xeqg1	66	22	.	.	.
cord-032403-9c1xeqg1	67	1	Thereby	thereby	RB
cord-032403-9c1xeqg1	67	2	,	,	,
cord-032403-9c1xeqg1	67	3	the	the	DT
cord-032403-9c1xeqg1	67	4	know	know	NN
cord-032403-9c1xeqg1	67	5	-	-	HYPH
cord-032403-9c1xeqg1	67	6	how	how	WRB
cord-032403-9c1xeqg1	67	7	is	be	VBZ
cord-032403-9c1xeqg1	67	8	provided	provide	VBN
cord-032403-9c1xeqg1	67	9	as	as	IN
cord-032403-9c1xeqg1	67	10	the	the	DT
cord-032403-9c1xeqg1	67	11	fundamental	fundamental	JJ
cord-032403-9c1xeqg1	67	12	backbone	backbone	NN
cord-032403-9c1xeqg1	67	13	based	base	VBN
cord-032403-9c1xeqg1	67	14	on	on	IN
cord-032403-9c1xeqg1	67	15	formalizing	formalize	VBG
cord-032403-9c1xeqg1	67	16	central	central	JJ
cord-032403-9c1xeqg1	67	17	process	process	NN
cord-032403-9c1xeqg1	67	18	characteristics	characteristic	NNS
cord-032403-9c1xeqg1	67	19	(	(	-LRB-
cord-032403-9c1xeqg1	67	20	e.g.	e.g.	RB
cord-032403-9c1xeqg1	67	21	,	,	,
cord-032403-9c1xeqg1	67	22	mass	mass	NN
cord-032403-9c1xeqg1	67	23	balances	balance	NNS
cord-032403-9c1xeqg1	67	24	)	)	-RRB-
cord-032403-9c1xeqg1	67	25	and	and	CC
cord-032403-9c1xeqg1	67	26	interrelationships	interrelationship	NNS
cord-032403-9c1xeqg1	67	27	(	(	-LRB-
cord-032403-9c1xeqg1	67	28	e.g.	e.g.	RB
cord-032403-9c1xeqg1	67	29	,	,	,
cord-032403-9c1xeqg1	67	30	characteristic	characteristic	JJ
cord-032403-9c1xeqg1	67	31	ratios	ratio	NNS
cord-032403-9c1xeqg1	67	32	or	or	CC
cord-032403-9c1xeqg1	67	33	dimensionless	dimensionless	JJ
cord-032403-9c1xeqg1	67	34	numbers	number	NNS
cord-032403-9c1xeqg1	67	35	)	)	-RRB-
cord-032403-9c1xeqg1	67	36	in	in	IN
cord-032403-9c1xeqg1	67	37	broadly	broadly	RB
cord-032403-9c1xeqg1	67	38	valid	valid	JJ
cord-032403-9c1xeqg1	67	39	model	model	NN
cord-032403-9c1xeqg1	67	40	equations	equation	NNS
cord-032403-9c1xeqg1	67	41	.	.	.
cord-032403-9c1xeqg1	68	1	As	as	IN
cord-032403-9c1xeqg1	68	2	explained	explain	VBN
cord-032403-9c1xeqg1	68	3	in	in	IN
cord-032403-9c1xeqg1	68	4	detail	detail	NN
cord-032403-9c1xeqg1	68	5	by	by	IN
cord-032403-9c1xeqg1	68	6	von	von	NNP
cord-032403-9c1xeqg1	68	7	Stosch	Stosch	NNP
cord-032403-9c1xeqg1	68	8	et	et	NNP
cord-032403-9c1xeqg1	68	9	al	al	NNP
cord-032403-9c1xeqg1	68	10	.	.	.
cord-032403-9c1xeqg1	69	1	17	17	CD
cord-032403-9c1xeqg1	69	2	and	and	CC
cord-032403-9c1xeqg1	69	3	Narayanan	Narayanan	NNP
cord-032403-9c1xeqg1	69	4	et	et	NNP
cord-032403-9c1xeqg1	69	5	al	al	NNP
cord-032403-9c1xeqg1	69	6	.	.	.
cord-032403-9c1xeqg1	70	1	,	,	,
cord-032403-9c1xeqg1	70	2	18	18	CD
cord-032403-9c1xeqg1	70	3	the	the	DT
cord-032403-9c1xeqg1	70	4	available	available	JJ
cord-032403-9c1xeqg1	70	5	data	data	NN
cord-032403-9c1xeqg1	70	6	is	be	VBZ
cord-032403-9c1xeqg1	70	7	then	then	RB
cord-032403-9c1xeqg1	70	8	used	use	VBN
cord-032403-9c1xeqg1	70	9	to	to	TO
cord-032403-9c1xeqg1	70	10	finetune	finetune	VB
cord-032403-9c1xeqg1	70	11	the	the	DT
cord-032403-9c1xeqg1	70	12	model	model	NN
cord-032403-9c1xeqg1	70	13	parameters	parameter	NNS
cord-032403-9c1xeqg1	70	14	to	to	IN
cord-032403-9c1xeqg1	70	15	the	the	DT
cord-032403-9c1xeqg1	70	16	considered	consider	VBN
cord-032403-9c1xeqg1	70	17	use	use	NN
cord-032403-9c1xeqg1	70	18	case	case	NN
cord-032403-9c1xeqg1	70	19	and	and	CC
cord-032403-9c1xeqg1	70	20	to	to	TO
cord-032403-9c1xeqg1	70	21	flexibly	flexibly	RB
cord-032403-9c1xeqg1	70	22	adapt	adapt	VB
cord-032403-9c1xeqg1	70	23	to	to	IN
cord-032403-9c1xeqg1	70	24	different	different	JJ
cord-032403-9c1xeqg1	70	25	scenarios	scenario	NNS
cord-032403-9c1xeqg1	70	26	.	.	.
cord-032403-9c1xeqg1	71	1	Figure	figure	NN
cord-032403-9c1xeqg1	71	2	2	2	CD
cord-032403-9c1xeqg1	71	3	compares	compare	VBZ
cord-032403-9c1xeqg1	71	4	the	the	DT
cord-032403-9c1xeqg1	71	5	concept	concept	NN
cord-032403-9c1xeqg1	71	6	of	of	IN
cord-032403-9c1xeqg1	71	7	hybrid	hybrid	JJ
cord-032403-9c1xeqg1	71	8	modeling	modeling	NN
cord-032403-9c1xeqg1	71	9	to	to	IN
cord-032403-9c1xeqg1	71	10	the	the	DT
cord-032403-9c1xeqg1	71	11	two	two	CD
cord-032403-9c1xeqg1	71	12	standard	standard	JJ
cord-032403-9c1xeqg1	71	13	modeling	modeling	NN
cord-032403-9c1xeqg1	71	14	approaches	approach	NNS
cord-032403-9c1xeqg1	71	15	,	,	,
cord-032403-9c1xeqg1	71	16	19	19	CD
cord-032403-9c1xeqg1	71	17	namely	namely	RB
cord-032403-9c1xeqg1	71	18	purely	purely	RB
cord-032403-9c1xeqg1	71	19	data	data	NN
cord-032403-9c1xeqg1	71	20	-	-	HYPH
cord-032403-9c1xeqg1	71	21	driven	drive	VBN
cord-032403-9c1xeqg1	71	22	(	(	-LRB-
cord-032403-9c1xeqg1	71	23	statistical	statistical	JJ
cord-032403-9c1xeqg1	71	24	)	)	-RRB-
cord-032403-9c1xeqg1	71	25	and	and	CC
cord-032403-9c1xeqg1	71	26	purely	purely	RB
cord-032403-9c1xeqg1	71	27	knowledge	knowledge	NN
cord-032403-9c1xeqg1	71	28	-	-	HYPH
cord-032403-9c1xeqg1	71	29	driven	drive	VBN
cord-032403-9c1xeqg1	71	30	(	(	-LRB-
cord-032403-9c1xeqg1	71	31	mechanistic	mechanistic	JJ
cord-032403-9c1xeqg1	71	32	)	)	-RRB-
cord-032403-9c1xeqg1	71	33	approaches	approach	NNS
cord-032403-9c1xeqg1	71	34	.	.	.
cord-032403-9c1xeqg1	72	1	On	on	IN
cord-032403-9c1xeqg1	72	2	the	the	DT
cord-032403-9c1xeqg1	72	3	side	side	NN
cord-032403-9c1xeqg1	72	4	of	of	IN
cord-032403-9c1xeqg1	72	5	assessing	assess	VBG
cord-032403-9c1xeqg1	72	6	the	the	DT
cord-032403-9c1xeqg1	72	7	process	process	NN
cord-032403-9c1xeqg1	72	8	behavior	behavior	NN
cord-032403-9c1xeqg1	72	9	by	by	IN
cord-032403-9c1xeqg1	72	10	a	a	DT
cord-032403-9c1xeqg1	72	11	process	process	NN
cord-032403-9c1xeqg1	72	12	expert	expert	NN
cord-032403-9c1xeqg1	72	13	perspective	perspective	NN
cord-032403-9c1xeqg1	72	14	,	,	,
cord-032403-9c1xeqg1	72	15	one	one	PRP
cord-032403-9c1xeqg1	72	16	could	could	MD
cord-032403-9c1xeqg1	72	17	either	either	CC
cord-032403-9c1xeqg1	72	18	rely	rely	VB
cord-032403-9c1xeqg1	72	19	on	on	IN
cord-032403-9c1xeqg1	72	20	statistical	statistical	JJ
cord-032403-9c1xeqg1	72	21	methods	method	NNS
cord-032403-9c1xeqg1	72	22	,	,	,
cord-032403-9c1xeqg1	72	23	which	which	WDT
cord-032403-9c1xeqg1	72	24	require	require	VBP
cord-032403-9c1xeqg1	72	25	a	a	DT
cord-032403-9c1xeqg1	72	26	lot	lot	NN
cord-032403-9c1xeqg1	72	27	of	of	IN
cord-032403-9c1xeqg1	72	28	data	datum	NNS
cord-032403-9c1xeqg1	72	29	to	to	TO
cord-032403-9c1xeqg1	72	30	support	support	VB
cord-032403-9c1xeqg1	72	31	decision	decision	NN
cord-032403-9c1xeqg1	72	32	making	make	VBG
cord-032403-9c1xeqg1	72	33	or	or	CC
cord-032403-9c1xeqg1	72	34	on	on	IN
cord-032403-9c1xeqg1	72	35	deterministic	deterministic	JJ
cord-032403-9c1xeqg1	72	36	methods	method	NNS
cord-032403-9c1xeqg1	72	37	,	,	,
cord-032403-9c1xeqg1	72	38	which	which	WDT
cord-032403-9c1xeqg1	72	39	can	can	MD
cord-032403-9c1xeqg1	72	40	only	only	RB
cord-032403-9c1xeqg1	72	41	be	be	VB
cord-032403-9c1xeqg1	72	42	formalized	formalize	VBN
cord-032403-9c1xeqg1	72	43	if	if	IN
cord-032403-9c1xeqg1	72	44	a	a	DT
cord-032403-9c1xeqg1	72	45	large	large	JJ
cord-032403-9c1xeqg1	72	46	part	part	NN
cord-032403-9c1xeqg1	72	47	of	of	IN
cord-032403-9c1xeqg1	72	48	the	the	DT
cord-032403-9c1xeqg1	72	49	behavior	behavior	NN
cord-032403-9c1xeqg1	72	50	is	be	VBZ
cord-032403-9c1xeqg1	72	51	well	well	RB
cord-032403-9c1xeqg1	72	52	understood	understand	VBN
cord-032403-9c1xeqg1	72	53	.	.	.
cord-032403-9c1xeqg1	73	1	The	the	DT
cord-032403-9c1xeqg1	73	2	first	first	JJ
cord-032403-9c1xeqg1	73	3	approach	approach	NN
cord-032403-9c1xeqg1	73	4	is	be	VBZ
cord-032403-9c1xeqg1	73	5	strictly	strictly	RB
cord-032403-9c1xeqg1	73	6	limited	limit	VBN
cord-032403-9c1xeqg1	73	7	by	by	IN
cord-032403-9c1xeqg1	73	8	the	the	DT
cord-032403-9c1xeqg1	73	9	amount	amount	NN
cord-032403-9c1xeqg1	73	10	of	of	IN
cord-032403-9c1xeqg1	73	11	available	available	JJ
cord-032403-9c1xeqg1	73	12	data	datum	NNS
cord-032403-9c1xeqg1	73	13	due	due	JJ
cord-032403-9c1xeqg1	73	14	to	to	IN
cord-032403-9c1xeqg1	73	15	the	the	DT
cord-032403-9c1xeqg1	73	16	large	large	JJ
cord-032403-9c1xeqg1	73	17	labor	labor	NN
cord-032403-9c1xeqg1	73	18	cost	cost	NN
cord-032403-9c1xeqg1	73	19	of	of	IN
cord-032403-9c1xeqg1	73	20	each	each	DT
cord-032403-9c1xeqg1	73	21	data	data	NN
cord-032403-9c1xeqg1	73	22	point	point	NN
cord-032403-9c1xeqg1	73	23	produced	produce	VBN
cord-032403-9c1xeqg1	73	24	combined	combine	VBN
cord-032403-9c1xeqg1	73	25	with	with	IN
cord-032403-9c1xeqg1	73	26	the	the	DT
cord-032403-9c1xeqg1	73	27	complexity	complexity	NN
cord-032403-9c1xeqg1	73	28	of	of	IN
cord-032403-9c1xeqg1	73	29	the	the	DT
cord-032403-9c1xeqg1	73	30	data	datum	NNS
cord-032403-9c1xeqg1	73	31	.	.	.
cord-032403-9c1xeqg1	74	1	12	12	CD
cord-032403-9c1xeqg1	74	2	,	,	,
cord-032403-9c1xeqg1	74	3	20	20	CD
cord-032403-9c1xeqg1	75	1	The	the	DT
cord-032403-9c1xeqg1	75	2	latter	latter	JJ
cord-032403-9c1xeqg1	75	3	is	be	VBZ
cord-032403-9c1xeqg1	75	4	limited	limit	VBN
cord-032403-9c1xeqg1	75	5	by	by	IN
cord-032403-9c1xeqg1	75	6	the	the	DT
cord-032403-9c1xeqg1	75	7	generally	generally	RB
cord-032403-9c1xeqg1	75	8	available	available	JJ
cord-032403-9c1xeqg1	75	9	understanding	understanding	NN
cord-032403-9c1xeqg1	75	10	of	of	IN
cord-032403-9c1xeqg1	75	11	the	the	DT
cord-032403-9c1xeqg1	75	12	complex	complex	JJ
cord-032403-9c1xeqg1	75	13	unit	unit	NN
cord-032403-9c1xeqg1	75	14	operations	operation	NNS
cord-032403-9c1xeqg1	75	15	as	as	RB
cord-032403-9c1xeqg1	75	16	well	well	RB
cord-032403-9c1xeqg1	75	17	as	as	IN
cord-032403-9c1xeqg1	75	18	the	the	DT
cord-032403-9c1xeqg1	75	19	availability	availability	NN
cord-032403-9c1xeqg1	75	20	of	of	IN
cord-032403-9c1xeqg1	75	21	an	an	DT
cord-032403-9c1xeqg1	75	22	expert	expert	NN
cord-032403-9c1xeqg1	75	23	for	for	IN
cord-032403-9c1xeqg1	75	24	each	each	DT
cord-032403-9c1xeqg1	75	25	of	of	IN
cord-032403-9c1xeqg1	75	26	them	-PRON-	PRP
cord-032403-9c1xeqg1	75	27	.	.	.
cord-032403-9c1xeqg1	76	1	11	11	CD
cord-032403-9c1xeqg1	76	2	,	,	,
cord-032403-9c1xeqg1	76	3	12	12	CD
cord-032403-9c1xeqg1	76	4	Therefore	therefore	RB
cord-032403-9c1xeqg1	76	5	,	,	,
cord-032403-9c1xeqg1	76	6	a	a	DT
cord-032403-9c1xeqg1	76	7	solution	solution	NN
cord-032403-9c1xeqg1	76	8	based	base	VBN
cord-032403-9c1xeqg1	76	9	on	on	IN
cord-032403-9c1xeqg1	76	10	combining	combine	VBG
cord-032403-9c1xeqg1	76	11	the	the	DT
cord-032403-9c1xeqg1	76	12	formalization	formalization	NN
cord-032403-9c1xeqg1	76	13	of	of	IN
cord-032403-9c1xeqg1	76	14	the	the	DT
cord-032403-9c1xeqg1	76	15	central	central	JJ
cord-032403-9c1xeqg1	76	16	know	know	NN
cord-032403-9c1xeqg1	76	17	-	-	HYPH
cord-032403-9c1xeqg1	76	18	how	how	NN
cord-032403-9c1xeqg1	76	19	with	with	IN
cord-032403-9c1xeqg1	76	20	the	the	DT
cord-032403-9c1xeqg1	76	21	flexible	flexible	JJ
cord-032403-9c1xeqg1	76	22	learning	learning	NN
cord-032403-9c1xeqg1	76	23	of	of	IN
cord-032403-9c1xeqg1	76	24	the	the	DT
cord-032403-9c1xeqg1	76	25	unknown	unknown	JJ
cord-032403-9c1xeqg1	76	26	remainder	remainder	NN
cord-032403-9c1xeqg1	76	27	from	from	IN
cord-032403-9c1xeqg1	76	28	the	the	DT
cord-032403-9c1xeqg1	76	29	available	available	JJ
cord-032403-9c1xeqg1	76	30	data	data	NN
cord-032403-9c1xeqg1	76	31	breaks	break	VBZ
cord-032403-9c1xeqg1	76	32	the	the	DT
cord-032403-9c1xeqg1	76	33	need	need	NN
cord-032403-9c1xeqg1	76	34	for	for	IN
cord-032403-9c1xeqg1	76	35	either	either	CC
cord-032403-9c1xeqg1	76	36	large	large	JJ
cord-032403-9c1xeqg1	76	37	data	data	NN
cord-032403-9c1xeqg1	76	38	sets	set	NNS
cord-032403-9c1xeqg1	76	39	or	or	CC
cord-032403-9c1xeqg1	76	40	the	the	DT
cord-032403-9c1xeqg1	76	41	continuous	continuous	JJ
cord-032403-9c1xeqg1	76	42	involvement	involvement	NN
cord-032403-9c1xeqg1	76	43	of	of	IN
cord-032403-9c1xeqg1	76	44	a	a	DT
cord-032403-9c1xeqg1	76	45	process	process	NN
cord-032403-9c1xeqg1	76	46	expert	expert	NN
cord-032403-9c1xeqg1	76	47	in	in	IN
cord-032403-9c1xeqg1	76	48	order	order	NN
cord-032403-9c1xeqg1	76	49	to	to	TO
cord-032403-9c1xeqg1	76	50	reliably	reliably	RB
cord-032403-9c1xeqg1	76	51	withdraw	withdraw	VB
cord-032403-9c1xeqg1	76	52	important	important	JJ
cord-032403-9c1xeqg1	76	53	decision	decision	NN
cord-032403-9c1xeqg1	76	54	support	support	NN
cord-032403-9c1xeqg1	76	55	.	.	.
cord-032403-9c1xeqg1	77	1	From	from	IN
cord-032403-9c1xeqg1	77	2	the	the	DT
cord-032403-9c1xeqg1	77	3	perspective	perspective	NN
cord-032403-9c1xeqg1	77	4	of	of	IN
cord-032403-9c1xeqg1	77	5	the	the	DT
cord-032403-9c1xeqg1	77	6	decision	decision	NN
cord-032403-9c1xeqg1	77	7	making	make	VBG
cord-032403-9c1xeqg1	77	8	stakeholders	stakeholder	NNS
cord-032403-9c1xeqg1	77	9	such	such	JJ
cord-032403-9c1xeqg1	77	10	algorithmic	algorithmic	JJ
cord-032403-9c1xeqg1	77	11	solution	solution	NN
cord-032403-9c1xeqg1	77	12	provides	provide	VBZ
cord-032403-9c1xeqg1	77	13	a	a	DT
cord-032403-9c1xeqg1	77	14	trustworthy	trustworthy	JJ
cord-032403-9c1xeqg1	77	15	decision	decision	NN
cord-032403-9c1xeqg1	77	16	base	base	NN
cord-032403-9c1xeqg1	77	17	with	with	IN
cord-032403-9c1xeqg1	77	18	less	less	JJR
cord-032403-9c1xeqg1	77	19	effort	effort	NN
cord-032403-9c1xeqg1	77	20	,	,	,
cord-032403-9c1xeqg1	77	21	that	that	RB
cord-032403-9c1xeqg1	77	22	is	is	RB
cord-032403-9c1xeqg1	77	23	,	,	,
cord-032403-9c1xeqg1	77	24	less	less	JJR
cord-032403-9c1xeqg1	77	25	time	time	NN
cord-032403-9c1xeqg1	77	26	and	and	CC
cord-032403-9c1xeqg1	77	27	labor	labor	NN
cord-032403-9c1xeqg1	77	28	to	to	TO
cord-032403-9c1xeqg1	77	29	conduct	conduct	VB
cord-032403-9c1xeqg1	77	30	experiments	experiment	NNS
cord-032403-9c1xeqg1	77	31	to	to	TO
cord-032403-9c1xeqg1	77	32	create	create	VB
cord-032403-9c1xeqg1	77	33	the	the	DT
cord-032403-9c1xeqg1	77	34	central	central	JJ
cord-032403-9c1xeqg1	77	35	know	know	NN
cord-032403-9c1xeqg1	77	36	-	-	HYPH
cord-032403-9c1xeqg1	77	37	how	how	NN
cord-032403-9c1xeqg1	77	38	and	and	CC
cord-032403-9c1xeqg1	77	39	less	less	JJR
cord-032403-9c1xeqg1	77	40	labor	labor	NN
cord-032403-9c1xeqg1	77	41	time	time	NN
cord-032403-9c1xeqg1	77	42	of	of	IN
cord-032403-9c1xeqg1	77	43	an	an	DT
cord-032403-9c1xeqg1	77	44	expert	expert	NN
cord-032403-9c1xeqg1	77	45	to	to	TO
cord-032403-9c1xeqg1	77	46	correctly	correctly	RB
cord-032403-9c1xeqg1	77	47	structure	structure	VB
cord-032403-9c1xeqg1	77	48	that	that	DT
cord-032403-9c1xeqg1	77	49	information	information	NN
cord-032403-9c1xeqg1	77	50	for	for	IN
cord-032403-9c1xeqg1	77	51	the	the	DT
cord-032403-9c1xeqg1	77	52	decision	decision	NN
cord-032403-9c1xeqg1	77	53	making	make	VBG
cord-032403-9c1xeqg1	77	54	perspective	perspective	NN
cord-032403-9c1xeqg1	77	55	.	.	.
cord-032403-9c1xeqg1	78	1	Figure	figure	NN
cord-032403-9c1xeqg1	78	2	3	3	CD
cord-032403-9c1xeqg1	78	3	supports	support	VBZ
cord-032403-9c1xeqg1	78	4	the	the	DT
cord-032403-9c1xeqg1	78	5	explanation	explanation	NN
cord-032403-9c1xeqg1	78	6	of	of	IN
cord-032403-9c1xeqg1	78	7	the	the	DT
cord-032403-9c1xeqg1	78	8	central	central	JJ
cord-032403-9c1xeqg1	78	9	role	role	NN
cord-032403-9c1xeqg1	78	10	of	of	IN
cord-032403-9c1xeqg1	78	11	hybrid	hybrid	JJ
cord-032403-9c1xeqg1	78	12	modeling	modeling	NN
cord-032403-9c1xeqg1	78	13	in	in	IN
cord-032403-9c1xeqg1	78	14	improving	improve	VBG
cord-032403-9c1xeqg1	78	15	trustworthiness	trustworthiness	NN
cord-032403-9c1xeqg1	78	16	and	and	CC
cord-032403-9c1xeqg1	78	17	decision	decision	NN
cord-032403-9c1xeqg1	78	18	support	support	NN
cord-032403-9c1xeqg1	78	19	in	in	IN
cord-032403-9c1xeqg1	78	20	process	process	NN
cord-032403-9c1xeqg1	78	21	design	design	NN
cord-032403-9c1xeqg1	78	22	and	and	CC
cord-032403-9c1xeqg1	78	23	failure	failure	NN
cord-032403-9c1xeqg1	78	24	detection	detection	NN
cord-032403-9c1xeqg1	78	25	.	.	.
cord-032403-9c1xeqg1	79	1	Standard	standard	JJ
cord-032403-9c1xeqg1	79	2	design	design	NN
cord-032403-9c1xeqg1	79	3	of	of	IN
cord-032403-9c1xeqg1	79	4	experiments	experiment	NNS
cord-032403-9c1xeqg1	79	5	methods	method	NNS
cord-032403-9c1xeqg1	79	6	21,22	21,22	CD
cord-032403-9c1xeqg1	79	7	try	try	VBP
cord-032403-9c1xeqg1	79	8	to	to	TO
cord-032403-9c1xeqg1	79	9	explain	explain	VB
cord-032403-9c1xeqg1	79	10	the	the	DT
cord-032403-9c1xeqg1	79	11	product	product	NN
cord-032403-9c1xeqg1	79	12	information	information	NN
cord-032403-9c1xeqg1	79	13	(	(	-LRB-
cord-032403-9c1xeqg1	79	14	Y	y	NN
cord-032403-9c1xeqg1	79	15	)	)	-RRB-
cord-032403-9c1xeqg1	79	16	based	base	VBN
cord-032403-9c1xeqg1	79	17	on	on	IN
cord-032403-9c1xeqg1	79	18	the	the	DT
cord-032403-9c1xeqg1	79	19	design	design	NN
cord-032403-9c1xeqg1	79	20	process	process	NN
cord-032403-9c1xeqg1	79	21	factors	factor	NNS
cord-032403-9c1xeqg1	79	22	(	(	-LRB-
cord-032403-9c1xeqg1	79	23	Z	z	NN
cord-032403-9c1xeqg1	79	24	)	)	-RRB-
cord-032403-9c1xeqg1	79	25	with	with	IN
cord-032403-9c1xeqg1	79	26	a	a	DT
cord-032403-9c1xeqg1	79	27	so	so	RB
cord-032403-9c1xeqg1	79	28	-	-	HYPH
cord-032403-9c1xeqg1	79	29	called	call	VBN
cord-032403-9c1xeqg1	79	30	"	"	``
cord-032403-9c1xeqg1	79	31	black	black	JJ
cord-032403-9c1xeqg1	79	32	-	-	HYPH
cord-032403-9c1xeqg1	79	33	box	box	NN
cord-032403-9c1xeqg1	79	34	"	"	''
cord-032403-9c1xeqg1	79	35	approach	approach	NN
cord-032403-9c1xeqg1	79	36	,	,	,
cord-032403-9c1xeqg1	79	37	that	that	RB
cord-032403-9c1xeqg1	79	38	is	is	RB
cord-032403-9c1xeqg1	79	39	,	,	,
cord-032403-9c1xeqg1	79	40	without	without	IN
cord-032403-9c1xeqg1	79	41	specifically	specifically	RB
cord-032403-9c1xeqg1	79	42	integrating	integrate	VBG
cord-032403-9c1xeqg1	79	43	mechanistic	mechanistic	JJ
cord-032403-9c1xeqg1	79	44	process	process	NN
cord-032403-9c1xeqg1	79	45	information	information	NN
cord-032403-9c1xeqg1	79	46	or	or	CC
cord-032403-9c1xeqg1	79	47	the	the	DT
cord-032403-9c1xeqg1	79	48	dynamic	dynamic	JJ
cord-032403-9c1xeqg1	79	49	process	process	NN
cord-032403-9c1xeqg1	79	50	information	information	NN
cord-032403-9c1xeqg1	79	51	(	(	-LRB-
cord-032403-9c1xeqg1	79	52	X	x	NN
cord-032403-9c1xeqg1	79	53	)	)	-RRB-
cord-032403-9c1xeqg1	79	54	.	.	.
cord-032403-9c1xeqg1	80	1	Taking	take	VBG
cord-032403-9c1xeqg1	80	2	simplistically	simplistically	RB
cord-032403-9c1xeqg1	80	3	the	the	DT
cord-032403-9c1xeqg1	80	4	Covid-19	covid-19	NN
cord-032403-9c1xeqg1	80	5	example	example	NN
cord-032403-9c1xeqg1	80	6	,	,	,
cord-032403-9c1xeqg1	80	7	this	this	DT
cord-032403-9c1xeqg1	80	8	could	could	MD
cord-032403-9c1xeqg1	80	9	be	be	VB
cord-032403-9c1xeqg1	80	10	interpreted	interpret	VBN
cord-032403-9c1xeqg1	80	11	as	as	IN
cord-032403-9c1xeqg1	80	12	trying	try	VBG
cord-032403-9c1xeqg1	80	13	to	to	TO
cord-032403-9c1xeqg1	80	14	understand	understand	VB
cord-032403-9c1xeqg1	80	15	how	how	WRB
cord-032403-9c1xeqg1	80	16	certain	certain	JJ
cord-032403-9c1xeqg1	80	17	imposed	impose	VBN
cord-032403-9c1xeqg1	80	18	restrictions	restriction	NNS
cord-032403-9c1xeqg1	80	19	affect	affect	VBP
cord-032403-9c1xeqg1	80	20	the	the	DT
cord-032403-9c1xeqg1	80	21	final	final	JJ
cord-032403-9c1xeqg1	80	22	lethality	lethality	NN
cord-032403-9c1xeqg1	80	23	of	of	IN
cord-032403-9c1xeqg1	80	24	the	the	DT
cord-032403-9c1xeqg1	80	25	period	period	NN
cord-032403-9c1xeqg1	80	26	under	under	IN
cord-032403-9c1xeqg1	80	27	these	these	DT
cord-032403-9c1xeqg1	80	28	restrictions	restriction	NNS
cord-032403-9c1xeqg1	80	29	without	without	IN
cord-032403-9c1xeqg1	80	30	anticipating	anticipate	VBG
cord-032403-9c1xeqg1	80	31	all	all	PDT
cord-032403-9c1xeqg1	80	32	the	the	DT
cord-032403-9c1xeqg1	80	33	trackable	trackable	JJ
cord-032403-9c1xeqg1	80	34	society	society	NN
cord-032403-9c1xeqg1	80	35	behavior	behavior	NN
cord-032403-9c1xeqg1	80	36	in	in	IN
cord-032403-9c1xeqg1	80	37	the	the	DT
cord-032403-9c1xeqg1	80	38	meantime	meantime	NN
cord-032403-9c1xeqg1	80	39	.	.	.
cord-032403-9c1xeqg1	81	1	The	the	DT
cord-032403-9c1xeqg1	81	2	X	x	NN
cord-032403-9c1xeqg1	81	3	information	information	NN
cord-032403-9c1xeqg1	81	4	therefore	therefore	RB
cord-032403-9c1xeqg1	81	5	bears	bear	VBZ
cord-032403-9c1xeqg1	81	6	a	a	DT
cord-032403-9c1xeqg1	81	7	central	central	JJ
cord-032403-9c1xeqg1	81	8	possibility	possibility	NN
cord-032403-9c1xeqg1	81	9	to	to	TO
cord-032403-9c1xeqg1	81	10	better	better	RB
cord-032403-9c1xeqg1	81	11	understand	understand	VB
cord-032403-9c1xeqg1	81	12	characteristic	characteristic	JJ
cord-032403-9c1xeqg1	81	13	dynamic	dynamic	JJ
cord-032403-9c1xeqg1	81	14	scenarios	scenario	NNS
cord-032403-9c1xeqg1	81	15	and	and	CC
cord-032403-9c1xeqg1	81	16	patterns	pattern	NNS
cord-032403-9c1xeqg1	81	17	,	,	,
cord-032403-9c1xeqg1	81	18	which	which	WDT
cord-032403-9c1xeqg1	81	19	might	may	MD
cord-032403-9c1xeqg1	81	20	result	result	VB
cord-032403-9c1xeqg1	81	21	in	in	IN
cord-032403-9c1xeqg1	81	22	a	a	DT
cord-032403-9c1xeqg1	81	23	different	different	JJ
cord-032403-9c1xeqg1	81	24	final	final	JJ
cord-032403-9c1xeqg1	81	25	outcome	outcome	NN
cord-032403-9c1xeqg1	82	1	Y.	Y.	NNP
cord-032403-9c1xeqg1	82	2	Hybrid	Hybrid	NNP
cord-032403-9c1xeqg1	82	3	modeling	modeling	NN
cord-032403-9c1xeqg1	82	4	enables	enable	VBZ
cord-032403-9c1xeqg1	82	5	a	a	DT
cord-032403-9c1xeqg1	82	6	simulation	simulation	NN
cord-032403-9c1xeqg1	82	7	,	,	,
cord-032403-9c1xeqg1	82	8	based	base	VBN
cord-032403-9c1xeqg1	82	9	on	on	IN
cord-032403-9c1xeqg1	82	10	the	the	DT
cord-032403-9c1xeqg1	82	11	integrated	integrated	JJ
cord-032403-9c1xeqg1	82	12	know	know	NN
cord-032403-9c1xeqg1	82	13	-	-	HYPH
cord-032403-9c1xeqg1	82	14	how	how	NN
cord-032403-9c1xeqg1	82	15	,	,	,
cord-032403-9c1xeqg1	82	16	of	of	IN
cord-032403-9c1xeqg1	82	17	how	how	WRB
cord-032403-9c1xeqg1	82	18	for	for	IN
cord-032403-9c1xeqg1	82	19	given	give	VBN
cord-032403-9c1xeqg1	82	20	initial	initial	JJ
cord-032403-9c1xeqg1	82	21	conditions	condition	NNS
cord-032403-9c1xeqg1	82	22	Z	Z	NNP
cord-032403-9c1xeqg1	82	23	a	a	DT
cord-032403-9c1xeqg1	82	24	process	process	NN
cord-032403-9c1xeqg1	82	25	could	could	MD
cord-032403-9c1xeqg1	82	26	evolve	evolve	VB
cord-032403-9c1xeqg1	82	27	.	.	.
cord-032403-9c1xeqg1	83	1	In	in	IN
cord-032403-9c1xeqg1	83	2	the	the	DT
cord-032403-9c1xeqg1	83	3	second	second	JJ
cord-032403-9c1xeqg1	83	4	step	step	NN
cord-032403-9c1xeqg1	83	5	this	this	DT
cord-032403-9c1xeqg1	83	6	predicted	predict	VBD
cord-032403-9c1xeqg1	83	7	evolution	evolution	NN
cord-032403-9c1xeqg1	83	8	is	be	VBZ
cord-032403-9c1xeqg1	83	9	linked	link	VBN
cord-032403-9c1xeqg1	83	10	based	base	VBN
cord-032403-9c1xeqg1	83	11	on	on	IN
cord-032403-9c1xeqg1	83	12	a	a	DT
cord-032403-9c1xeqg1	83	13	historical	historical	JJ
cord-032403-9c1xeqg1	83	14	model	model	NN
cord-032403-9c1xeqg1	83	15	23	23	CD
cord-032403-9c1xeqg1	83	16	to	to	IN
cord-032403-9c1xeqg1	83	17	the	the	DT
cord-032403-9c1xeqg1	83	18	final	final	JJ
cord-032403-9c1xeqg1	83	19	product	product	NN
cord-032403-9c1xeqg1	83	20	quality	quality	NN
cord-032403-9c1xeqg1	83	21	Y.	Y.	NNP
cord-032403-9c1xeqg1	83	22	Hence	Hence	NNP
cord-032403-9c1xeqg1	83	23	,	,	,
cord-032403-9c1xeqg1	83	24	while	while	IN
cord-032403-9c1xeqg1	83	25	retaining	retain	VBG
cord-032403-9c1xeqg1	83	26	the	the	DT
cord-032403-9c1xeqg1	83	27	general	general	JJ
cord-032403-9c1xeqg1	83	28	goal	goal	NN
cord-032403-9c1xeqg1	83	29	of	of	IN
cord-032403-9c1xeqg1	83	30	finding	find	VBG
cord-032403-9c1xeqg1	83	31	the	the	DT
cord-032403-9c1xeqg1	83	32	optimal	optimal	JJ
cord-032403-9c1xeqg1	83	33	conditions	condition	NNS
cord-032403-9c1xeqg1	83	34	Z	Z	NNP
cord-032403-9c1xeqg1	83	35	to	to	TO
cord-032403-9c1xeqg1	83	36	reach	reach	VB
cord-032403-9c1xeqg1	83	37	the	the	DT
cord-032403-9c1xeqg1	83	38	target	target	NN
cord-032403-9c1xeqg1	83	39	outcome	outcome	NN
cord-032403-9c1xeqg1	83	40	Y	Y	NNP
cord-032403-9c1xeqg1	83	41	optimal	optimal	NN
cord-032403-9c1xeqg1	83	42	,	,	,
cord-032403-9c1xeqg1	83	43	this	this	DT
cord-032403-9c1xeqg1	83	44	procedure	procedure	NN
cord-032403-9c1xeqg1	83	45	supplements	supplement	VBZ
cord-032403-9c1xeqg1	83	46	a	a	DT
cord-032403-9c1xeqg1	83	47	lot	lot	NN
cord-032403-9c1xeqg1	83	48	of	of	IN
cord-032403-9c1xeqg1	83	49	certainty	certainty	NN
cord-032403-9c1xeqg1	83	50	on	on	IN
cord-032403-9c1xeqg1	83	51	the	the	DT
cord-032403-9c1xeqg1	83	52	final	final	JJ
cord-032403-9c1xeqg1	83	53	outcome	outcome	NN
cord-032403-9c1xeqg1	83	54	compared	compare	VBN
cord-032403-9c1xeqg1	83	55	to	to	IN
cord-032403-9c1xeqg1	83	56	the	the	DT
cord-032403-9c1xeqg1	83	57	black	black	JJ
cord-032403-9c1xeqg1	83	58	-	-	HYPH
cord-032403-9c1xeqg1	83	59	box	box	NN
cord-032403-9c1xeqg1	83	60	approach	approach	NN
cord-032403-9c1xeqg1	83	61	,	,	,
cord-032403-9c1xeqg1	83	62	based	base	VBN
cord-032403-9c1xeqg1	83	63	on	on	IN
cord-032403-9c1xeqg1	83	64	a	a	DT
cord-032403-9c1xeqg1	83	65	knowledge	knowledge	NN
cord-032403-9c1xeqg1	83	66	-	-	HYPH
cord-032403-9c1xeqg1	83	67	supported	support	VBN
cord-032403-9c1xeqg1	83	68	,	,	,
cord-032403-9c1xeqg1	83	69	projected	project	VBN
cord-032403-9c1xeqg1	83	70	architecture	architecture	NN
cord-032403-9c1xeqg1	83	71	of	of	IN
cord-032403-9c1xeqg1	83	72	possible	possible	JJ
cord-032403-9c1xeqg1	83	73	bridges	bridge	NNS
cord-032403-9c1xeqg1	83	74	between	between	IN
cord-032403-9c1xeqg1	83	75	process	process	NN
cord-032403-9c1xeqg1	83	76	start	start	NN
cord-032403-9c1xeqg1	83	77	and	and	CC
cord-032403-9c1xeqg1	83	78	end	end	VB
cord-032403-9c1xeqg1	83	79	.	.	.
cord-032403-9c1xeqg1	84	1	In	in	IN
cord-032403-9c1xeqg1	84	2	the	the	DT
cord-032403-9c1xeqg1	84	3	absence	absence	NN
cord-032403-9c1xeqg1	84	4	of	of	IN
cord-032403-9c1xeqg1	84	5	long	long	RB
cord-032403-9c1xeqg1	84	6	-	-	HYPH
cord-032403-9c1xeqg1	84	7	standing	stand	VBG
cord-032403-9c1xeqg1	84	8	experience	experience	NN
cord-032403-9c1xeqg1	84	9	in	in	IN
cord-032403-9c1xeqg1	84	10	the	the	DT
cord-032403-9c1xeqg1	84	11	problem	problem	NN
cord-032403-9c1xeqg1	84	12	field	field	NN
cord-032403-9c1xeqg1	84	13	,	,	,
cord-032403-9c1xeqg1	84	14	such	such	JJ
cord-032403-9c1xeqg1	84	15	dynamic	dynamic	JJ
cord-032403-9c1xeqg1	84	16	progression	progression	NN
cord-032403-9c1xeqg1	84	17	can	can	MD
cord-032403-9c1xeqg1	84	18	be	be	VB
cord-032403-9c1xeqg1	84	19	also	also	RB
cord-032403-9c1xeqg1	84	20	simulated	simulate	VBN
cord-032403-9c1xeqg1	84	21	based	base	VBN
cord-032403-9c1xeqg1	84	22	on	on	IN
cord-032403-9c1xeqg1	84	23	simple	simple	JJ
cord-032403-9c1xeqg1	84	24	,	,	,
cord-032403-9c1xeqg1	84	25	yet	yet	CC
cord-032403-9c1xeqg1	84	26	effective	effective	JJ
cord-032403-9c1xeqg1	84	27	dynamic	dynamic	JJ
cord-032403-9c1xeqg1	84	28	interrelationships	interrelationship	NNS
cord-032403-9c1xeqg1	84	29	or	or	CC
cord-032403-9c1xeqg1	84	30	based	base	VBN
cord-032403-9c1xeqg1	84	31	on	on	IN
cord-032403-9c1xeqg1	84	32	stochastic	stochastic	JJ
cord-032403-9c1xeqg1	84	33	approaches	approach	NNS
cord-032403-9c1xeqg1	84	34	,	,	,
cord-032403-9c1xeqg1	84	35	which	which	WDT
cord-032403-9c1xeqg1	84	36	are	be	VBP
cord-032403-9c1xeqg1	84	37	both	both	DT
cord-032403-9c1xeqg1	84	38	also	also	RB
cord-032403-9c1xeqg1	84	39	being	be	VBG
cord-032403-9c1xeqg1	84	40	utilized	utilize	VBN
cord-032403-9c1xeqg1	84	41	in	in	IN
cord-032403-9c1xeqg1	84	42	modeling	model	VBG
cord-032403-9c1xeqg1	84	43	the	the	DT
cord-032403-9c1xeqg1	84	44	Covid-19	covid-19	NN
cord-032403-9c1xeqg1	84	45	pandemic	pandemic	NN
cord-032403-9c1xeqg1	84	46	.	.	.
cord-032403-9c1xeqg1	85	1	1	1	CD
cord-032403-9c1xeqg1	85	2	,	,	,
cord-032403-9c1xeqg1	85	3	24	24	CD
cord-032403-9c1xeqg1	85	4	,	,	,
cord-032403-9c1xeqg1	85	5	25	25	CD
cord-032403-9c1xeqg1	86	1	In	in	IN
cord-032403-9c1xeqg1	86	2	the	the	DT
cord-032403-9c1xeqg1	86	3	past	past	JJ
cord-032403-9c1xeqg1	86	4	few	few	JJ
cord-032403-9c1xeqg1	86	5	years	year	NNS
cord-032403-9c1xeqg1	86	6	,	,	,
cord-032403-9c1xeqg1	86	7	hybrid	hybrid	JJ
cord-032403-9c1xeqg1	86	8	modeling	modeling	NN
cord-032403-9c1xeqg1	86	9	has	have	VBZ
cord-032403-9c1xeqg1	86	10	become	become	VBN
cord-032403-9c1xeqg1	86	11	increasingly	increasingly	RB
cord-032403-9c1xeqg1	86	12	popular	popular	JJ
cord-032403-9c1xeqg1	86	13	in	in	IN
cord-032403-9c1xeqg1	86	14	the	the	DT
cord-032403-9c1xeqg1	86	15	bioprocessing	bioprocesse	VBG
cord-032403-9c1xeqg1	86	16	domain	domain	NN
cord-032403-9c1xeqg1	86	17	leading	lead	VBG
cord-032403-9c1xeqg1	86	18	to	to	TO
cord-032403-9c1xeqg1	86	19	be	be	VB
cord-032403-9c1xeqg1	86	20	considered	consider	VBN
cord-032403-9c1xeqg1	86	21	a	a	DT
cord-032403-9c1xeqg1	86	22	main	main	JJ
cord-032403-9c1xeqg1	86	23	new	new	JJ
cord-032403-9c1xeqg1	86	24	direction	direction	NN
cord-032403-9c1xeqg1	86	25	.	.	.
cord-032403-9c1xeqg1	87	1	26	26	CD
cord-032403-9c1xeqg1	87	2	Hybrid	hybrid	NN
cord-032403-9c1xeqg1	87	3	modeling	modeling	NN
cord-032403-9c1xeqg1	87	4	,	,	,
cord-032403-9c1xeqg1	87	5	in	in	IN
cord-032403-9c1xeqg1	87	6	the	the	DT
cord-032403-9c1xeqg1	87	7	context	context	NN
cord-032403-9c1xeqg1	87	8	of	of	IN
cord-032403-9c1xeqg1	87	9	therapeutic	therapeutic	JJ
cord-032403-9c1xeqg1	87	10	protein	protein	NN
cord-032403-9c1xeqg1	87	11	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	87	12	models	model	NNS
cord-032403-9c1xeqg1	87	13	,	,	,
cord-032403-9c1xeqg1	87	14	demonstrated	demonstrate	VBD
cord-032403-9c1xeqg1	87	15	its	-PRON-	PRP$
cord-032403-9c1xeqg1	87	16	enabling	enable	VBG
cord-032403-9c1xeqg1	87	17	potential	potential	NN
cord-032403-9c1xeqg1	87	18	in	in	IN
cord-032403-9c1xeqg1	87	19	applications	application	NNS
cord-032403-9c1xeqg1	87	20	such	such	JJ
cord-032403-9c1xeqg1	87	21	as	as	IN
cord-032403-9c1xeqg1	87	22	monitoring	monitoring	NN
cord-032403-9c1xeqg1	87	23	and	and	CC
cord-032403-9c1xeqg1	87	24	forecasting	forecasting	NN
cord-032403-9c1xeqg1	87	25	,	,	,
cord-032403-9c1xeqg1	87	26	27,28	27,28	CD
cord-032403-9c1xeqg1	87	27	control	control	NN
cord-032403-9c1xeqg1	87	28	,	,	,
cord-032403-9c1xeqg1	87	29	29,30	29,30	CD
cord-032403-9c1xeqg1	87	30	optimization	optimization	NN
cord-032403-9c1xeqg1	87	31	,	,	,
cord-032403-9c1xeqg1	87	32	31	31	CD
cord-032403-9c1xeqg1	87	33	,	,	,
cord-032403-9c1xeqg1	87	34	32	32	CD
cord-032403-9c1xeqg1	87	35	and	and	CC
cord-032403-9c1xeqg1	87	36	also	also	RB
cord-032403-9c1xeqg1	87	37	in	in	IN
cord-032403-9c1xeqg1	87	38	downstream	downstream	JJ
cord-032403-9c1xeqg1	87	39	processing	processing	NN
cord-032403-9c1xeqg1	87	40	.	.	.
cord-032403-9c1xeqg1	88	1	33	33	CD
cord-032403-9c1xeqg1	89	1	Despite	despite	IN
cord-032403-9c1xeqg1	89	2	real	real	JJ
cord-032403-9c1xeqg1	89	3	-	-	HYPH
cord-032403-9c1xeqg1	89	4	world	world	NN
cord-032403-9c1xeqg1	89	5	problems	problem	NNS
cord-032403-9c1xeqg1	89	6	seldom	seldom	RB
cord-032403-9c1xeqg1	89	7	existing	exist	VBG
cord-032403-9c1xeqg1	89	8	in	in	IN
cord-032403-9c1xeqg1	89	9	isolation	isolation	NN
cord-032403-9c1xeqg1	89	10	,	,	,
cord-032403-9c1xeqg1	89	11	heterogeneity	heterogeneity	NN
cord-032403-9c1xeqg1	89	12	is	be	VBZ
cord-032403-9c1xeqg1	89	13	often	often	RB
cord-032403-9c1xeqg1	89	14	a	a	DT
cord-032403-9c1xeqg1	89	15	governing	govern	VBG
cord-032403-9c1xeqg1	89	16	factor	factor	NN
cord-032403-9c1xeqg1	89	17	in	in	IN
cord-032403-9c1xeqg1	89	18	finding	find	VBG
cord-032403-9c1xeqg1	89	19	a	a	DT
cord-032403-9c1xeqg1	89	20	solution	solution	NN
cord-032403-9c1xeqg1	89	21	.	.	.
cord-032403-9c1xeqg1	90	1	This	this	DT
cord-032403-9c1xeqg1	90	2	means	mean	VBZ
cord-032403-9c1xeqg1	90	3	that	that	IN
cord-032403-9c1xeqg1	90	4	despite	despite	IN
cord-032403-9c1xeqg1	90	5	the	the	DT
cord-032403-9c1xeqg1	90	6	availability	availability	NN
cord-032403-9c1xeqg1	90	7	of	of	IN
cord-032403-9c1xeqg1	90	8	some	some	DT
cord-032403-9c1xeqg1	90	9	prior	prior	JJ
cord-032403-9c1xeqg1	90	10	data	datum	NNS
cord-032403-9c1xeqg1	90	11	and/	and/	NNP
cord-032403-9c1xeqg1	90	12	or	or	CC
cord-032403-9c1xeqg1	90	13	know	know	NN
cord-032403-9c1xeqg1	90	14	-	-	HYPH
cord-032403-9c1xeqg1	90	15	how	how	NN
cord-032403-9c1xeqg1	90	16	,	,	,
cord-032403-9c1xeqg1	90	17	their	-PRON-	PRP$
cord-032403-9c1xeqg1	90	18	alignment	alignment	NN
cord-032403-9c1xeqg1	90	19	is	be	VBZ
cord-032403-9c1xeqg1	90	20	complex	complex	JJ
cord-032403-9c1xeqg1	90	21	due	due	IN
cord-032403-9c1xeqg1	90	22	to	to	IN
cord-032403-9c1xeqg1	90	23	structural	structural	JJ
cord-032403-9c1xeqg1	90	24	or	or	CC
cord-032403-9c1xeqg1	90	25	phenomenological	phenomenological	JJ
cord-032403-9c1xeqg1	90	26	differences	difference	NNS
cord-032403-9c1xeqg1	90	27	.	.	.
cord-032403-9c1xeqg1	91	1	The	the	DT
cord-032403-9c1xeqg1	91	2	characteristic	characteristic	JJ
cord-032403-9c1xeqg1	91	3	sequence	sequence	NN
cord-032403-9c1xeqg1	91	4	of	of	IN
cord-032403-9c1xeqg1	91	5	the	the	DT
cord-032403-9c1xeqg1	91	6	Covid-19	covid-19	JJ
cord-032403-9c1xeqg1	91	7	pandemic	pandemic	NN
cord-032403-9c1xeqg1	91	8	spread	spread	NN
cord-032403-9c1xeqg1	91	9	provides	provide	VBZ
cord-032403-9c1xeqg1	91	10	countries	country	NNS
cord-032403-9c1xeqg1	91	11	affected	affect	VBN
cord-032403-9c1xeqg1	91	12	at	at	IN
cord-032403-9c1xeqg1	91	13	later	later	RB
cord-032403-9c1xeqg1	91	14	stages	stage	VBZ
cord-032403-9c1xeqg1	91	15	the	the	DT
cord-032403-9c1xeqg1	91	16	possibility	possibility	NN
cord-032403-9c1xeqg1	91	17	to	to	TO
cord-032403-9c1xeqg1	91	18	learn	learn	VB
cord-032403-9c1xeqg1	91	19	from	from	IN
cord-032403-9c1xeqg1	91	20	the	the	DT
cord-032403-9c1xeqg1	91	21	data	datum	NNS
cord-032403-9c1xeqg1	91	22	from	from	IN
cord-032403-9c1xeqg1	91	23	the	the	DT
cord-032403-9c1xeqg1	91	24	previously	previously	RB
cord-032403-9c1xeqg1	91	25	affected	affect	VBN
cord-032403-9c1xeqg1	91	26	ones	one	NNS
cord-032403-9c1xeqg1	91	27	.	.	.
cord-032403-9c1xeqg1	92	1	Such	such	JJ
cord-032403-9c1xeqg1	92	2	learning	learning	NN
cord-032403-9c1xeqg1	92	3	is	be	VBZ
cord-032403-9c1xeqg1	92	4	obviously	obviously	RB
cord-032403-9c1xeqg1	92	5	limited	limit	VBN
cord-032403-9c1xeqg1	92	6	as	as	IN
cord-032403-9c1xeqg1	92	7	countries	country	NNS
cord-032403-9c1xeqg1	92	8	strongly	strongly	RB
cord-032403-9c1xeqg1	92	9	vary	vary	VBP
cord-032403-9c1xeqg1	92	10	in	in	IN
cord-032403-9c1xeqg1	92	11	organization	organization	NN
cord-032403-9c1xeqg1	92	12	and	and	CC
cord-032403-9c1xeqg1	92	13	capacity	capacity	NN
cord-032403-9c1xeqg1	92	14	of	of	IN
cord-032403-9c1xeqg1	92	15	their	-PRON-	PRP$
cord-032403-9c1xeqg1	92	16	health	health	NN
cord-032403-9c1xeqg1	92	17	system	system	NN
cord-032403-9c1xeqg1	92	18	,	,	,
cord-032403-9c1xeqg1	92	19	population	population	NN
cord-032403-9c1xeqg1	92	20	size	size	NN
cord-032403-9c1xeqg1	92	21	and	and	CC
cord-032403-9c1xeqg1	92	22	density	density	NN
cord-032403-9c1xeqg1	92	23	,	,	,
cord-032403-9c1xeqg1	92	24	and	and	CC
cord-032403-9c1xeqg1	92	25	geographical	geographical	JJ
cord-032403-9c1xeqg1	92	26	location	location	NN
cord-032403-9c1xeqg1	92	27	,	,	,
cord-032403-9c1xeqg1	92	28	etc	etc	FW
cord-032403-9c1xeqg1	92	29	.	.	.
cord-032403-9c1xeqg1	93	1	Nonetheless	nonetheless	RB
cord-032403-9c1xeqg1	93	2	,	,	,
cord-032403-9c1xeqg1	93	3	certain	certain	JJ
cord-032403-9c1xeqg1	93	4	effects	effect	NNS
cord-032403-9c1xeqg1	93	5	such	such	JJ
cord-032403-9c1xeqg1	93	6	as	as	IN
cord-032403-9c1xeqg1	93	7	characteristic	characteristic	JJ
cord-032403-9c1xeqg1	93	8	symptoms	symptom	NNS
cord-032403-9c1xeqg1	93	9	,	,	,
cord-032403-9c1xeqg1	93	10	contagiousness	contagiousness	NN
cord-032403-9c1xeqg1	93	11	,	,	,
cord-032403-9c1xeqg1	93	12	risk	risk	NN
cord-032403-9c1xeqg1	93	13	groups	group	NNS
cord-032403-9c1xeqg1	93	14	,	,	,
cord-032403-9c1xeqg1	93	15	lethality	lethality	NN
cord-032403-9c1xeqg1	93	16	,	,	,
cord-032403-9c1xeqg1	93	17	etc	etc	FW
cord-032403-9c1xeqg1	93	18	.	.	.
cord-032403-9c1xeqg1	93	19	could	could	MD
cord-032403-9c1xeqg1	93	20	be	be	VB
cord-032403-9c1xeqg1	93	21	identified	identify	VBN
cord-032403-9c1xeqg1	93	22	even	even	RB
cord-032403-9c1xeqg1	93	23	without	without	IN
cord-032403-9c1xeqg1	93	24	or	or	CC
cord-032403-9c1xeqg1	93	25	with	with	IN
cord-032403-9c1xeqg1	93	26	limited	limited	JJ
cord-032403-9c1xeqg1	93	27	data	datum	NNS
cord-032403-9c1xeqg1	93	28	available	available	JJ
cord-032403-9c1xeqg1	93	29	.	.	.
cord-032403-9c1xeqg1	94	1	Human	human	JJ
cord-032403-9c1xeqg1	94	2	beings	being	NNS
cord-032403-9c1xeqg1	94	3	possess	possess	VBP
cord-032403-9c1xeqg1	94	4	a	a	DT
cord-032403-9c1xeqg1	94	5	powerful	powerful	JJ
cord-032403-9c1xeqg1	94	6	cognitive	cognitive	JJ
cord-032403-9c1xeqg1	94	7	ability	ability	NN
cord-032403-9c1xeqg1	94	8	for	for	IN
cord-032403-9c1xeqg1	94	9	such	such	JJ
cord-032403-9c1xeqg1	94	10	knowledge	knowledge	NN
cord-032403-9c1xeqg1	94	11	transfer	transfer	NN
cord-032403-9c1xeqg1	94	12	,	,	,
cord-032403-9c1xeqg1	94	13	while	while	IN
cord-032403-9c1xeqg1	94	14	traditional	traditional	JJ
cord-032403-9c1xeqg1	94	15	optimization	optimization	NN
cord-032403-9c1xeqg1	94	16	solvers	solver	NNS
cord-032403-9c1xeqg1	94	17	usually	usually	RB
cord-032403-9c1xeqg1	94	18	lack	lack	VBP
cord-032403-9c1xeqg1	94	19	such	such	JJ
cord-032403-9c1xeqg1	94	20	ability	ability	NN
cord-032403-9c1xeqg1	94	21	in	in	IN
cord-032403-9c1xeqg1	94	22	their	-PRON-	PRP$
cord-032403-9c1xeqg1	94	23	search	search	NN
cord-032403-9c1xeqg1	94	24	strategy	strategy	NN
cord-032403-9c1xeqg1	94	25	.	.	.
cord-032403-9c1xeqg1	95	1	34	34	CD
cord-032403-9c1xeqg1	96	1	In	in	IN
cord-032403-9c1xeqg1	96	2	machine	machine	NN
cord-032403-9c1xeqg1	96	3	learning	learn	VBG
cord-032403-9c1xeqg1	96	4	such	such	PDT
cord-032403-9c1xeqg1	96	5	a	a	DT
cord-032403-9c1xeqg1	96	6	concept	concept	NN
cord-032403-9c1xeqg1	96	7	is	be	VBZ
cord-032403-9c1xeqg1	96	8	described	describe	VBN
cord-032403-9c1xeqg1	96	9	as	as	IN
cord-032403-9c1xeqg1	96	10	transfer	transfer	NN
cord-032403-9c1xeqg1	96	11	learning	learning	NN
cord-032403-9c1xeqg1	96	12	,	,	,
cord-032403-9c1xeqg1	96	13	35	35	CD
cord-032403-9c1xeqg1	96	14	where	where	WRB
cord-032403-9c1xeqg1	96	15	one	one	CD
cord-032403-9c1xeqg1	96	16	"	"	``
cord-032403-9c1xeqg1	96	17	generic	generic	JJ
cord-032403-9c1xeqg1	96	18	"	"	''
cord-032403-9c1xeqg1	96	19	part	part	NN
cord-032403-9c1xeqg1	96	20	of	of	IN
cord-032403-9c1xeqg1	96	21	the	the	DT
cord-032403-9c1xeqg1	96	22	model	model	NN
cord-032403-9c1xeqg1	96	23	,	,	,
cord-032403-9c1xeqg1	96	24	usually	usually	RB
cord-032403-9c1xeqg1	96	25	the	the	DT
cord-032403-9c1xeqg1	96	26	first	first	JJ
cord-032403-9c1xeqg1	96	27	layers	layer	NNS
cord-032403-9c1xeqg1	96	28	of	of	IN
cord-032403-9c1xeqg1	96	29	a	a	DT
cord-032403-9c1xeqg1	96	30	convolutional	convolutional	JJ
cord-032403-9c1xeqg1	96	31	neural	neural	JJ
cord-032403-9c1xeqg1	96	32	net	net	NN
cord-032403-9c1xeqg1	96	33	,	,	,
cord-032403-9c1xeqg1	96	34	is	be	VBZ
cord-032403-9c1xeqg1	96	35	learnt	learn	VBN
cord-032403-9c1xeqg1	96	36	from	from	IN
cord-032403-9c1xeqg1	96	37	generally	generally	RB
cord-032403-9c1xeqg1	96	38	available	available	JJ
cord-032403-9c1xeqg1	96	39	data	datum	NNS
cord-032403-9c1xeqg1	96	40	and	and	CC
cord-032403-9c1xeqg1	96	41	then	then	RB
cord-032403-9c1xeqg1	96	42	the	the	DT
cord-032403-9c1xeqg1	96	43	data	datum	NNS
cord-032403-9c1xeqg1	96	44	of	of	IN
cord-032403-9c1xeqg1	96	45	a	a	DT
cord-032403-9c1xeqg1	96	46	specific	specific	JJ
cord-032403-9c1xeqg1	96	47	system	system	NN
cord-032403-9c1xeqg1	96	48	is	be	VBZ
cord-032403-9c1xeqg1	96	49	used	use	VBN
cord-032403-9c1xeqg1	96	50	to	to	TO
cord-032403-9c1xeqg1	96	51	fine	fine	JJ
cord-032403-9c1xeqg1	96	52	-	-	HYPH
cord-032403-9c1xeqg1	96	53	tune	tune	VB
cord-032403-9c1xeqg1	96	54	the	the	DT
cord-032403-9c1xeqg1	96	55	model	model	NN
cord-032403-9c1xeqg1	96	56	to	to	IN
cord-032403-9c1xeqg1	96	57	that	that	DT
cord-032403-9c1xeqg1	96	58	specific	specific	JJ
cord-032403-9c1xeqg1	96	59	use	use	NN
cord-032403-9c1xeqg1	96	60	case	case	NN
cord-032403-9c1xeqg1	96	61	.	.	.
cord-032403-9c1xeqg1	97	1	36	36	CD
cord-032403-9c1xeqg1	97	2	.	.	.
cord-032403-9c1xeqg1	98	1	Enabling	enable	VBG
cord-032403-9c1xeqg1	98	2	possibility	possibility	NN
cord-032403-9c1xeqg1	98	3	of	of	IN
cord-032403-9c1xeqg1	98	4	hybrid	hybrid	JJ
cord-032403-9c1xeqg1	98	5	modeling	modeling	NN
cord-032403-9c1xeqg1	98	6	to	to	TO
cord-032403-9c1xeqg1	98	7	learn	learn	VB
cord-032403-9c1xeqg1	98	8	process	process	NN
cord-032403-9c1xeqg1	98	9	dynamics	dynamic	NNS
cord-032403-9c1xeqg1	98	10	and	and	CC
cord-032403-9c1xeqg1	98	11	support	support	NN
cord-032403-9c1xeqg1	98	12	forecast	forecast	NN
cord-032403-9c1xeqg1	98	13	of	of	IN
cord-032403-9c1xeqg1	98	14	final	final	JJ
cord-032403-9c1xeqg1	98	15	product	product	NN
cord-032403-9c1xeqg1	98	16	quality	quality	NN
cord-032403-9c1xeqg1	98	17	.	.	.
cord-032403-9c1xeqg1	99	1	Such	such	JJ
cord-032403-9c1xeqg1	99	2	a	a	DT
cord-032403-9c1xeqg1	99	3	two	two	CD
cord-032403-9c1xeqg1	99	4	-	-	HYPH
cord-032403-9c1xeqg1	99	5	step	step	NN
cord-032403-9c1xeqg1	99	6	procedure	procedure	NN
cord-032403-9c1xeqg1	99	7	enables	enable	VBZ
cord-032403-9c1xeqg1	99	8	complete	complete	JJ
cord-032403-9c1xeqg1	99	9	simulation	simulation	NN
cord-032403-9c1xeqg1	99	10	of	of	IN
cord-032403-9c1xeqg1	99	11	process	process	NN
cord-032403-9c1xeqg1	99	12	and	and	CC
cord-032403-9c1xeqg1	99	13	product	product	NN
cord-032403-9c1xeqg1	99	14	quality	quality	NN
cord-032403-9c1xeqg1	99	15	based	base	VBN
cord-032403-9c1xeqg1	99	16	on	on	IN
cord-032403-9c1xeqg1	99	17	different	different	JJ
cord-032403-9c1xeqg1	99	18	process	process	NN
cord-032403-9c1xeqg1	99	19	designs	design	NNS
cord-032403-9c1xeqg1	99	20	and	and	CC
cord-032403-9c1xeqg1	99	21	optimizing	optimize	VBG
cord-032403-9c1xeqg1	99	22	the	the	DT
cord-032403-9c1xeqg1	99	23	design	design	NN
cord-032403-9c1xeqg1	99	24	space	space	NN
cord-032403-9c1xeqg1	99	25	to	to	TO
cord-032403-9c1xeqg1	99	26	reach	reach	VB
cord-032403-9c1xeqg1	99	27	optimal	optimal	JJ
cord-032403-9c1xeqg1	99	28	product	product	NN
cord-032403-9c1xeqg1	99	29	quality	quality	NN
cord-032403-9c1xeqg1	99	30	.	.	.
cord-032403-9c1xeqg1	100	1	Industrial	Industrial	NNP
cord-032403-9c1xeqg1	100	2	&	&	CC
cord-032403-9c1xeqg1	100	3	Engineering	Engineering	NNP
cord-032403-9c1xeqg1	100	4	Chemistry	Chemistry	NNP
cord-032403-9c1xeqg1	101	1	Research	research	NN
cord-032403-9c1xeqg1	101	2	pubs.acs.org/IECR	pubs.acs.org/iecr	NN
cord-032403-9c1xeqg1	101	3	Commentary	commentary	NN
cord-032403-9c1xeqg1	102	1	In	in	IN
cord-032403-9c1xeqg1	102	2	many	many	JJ
cord-032403-9c1xeqg1	102	3	engineering	engineering	NN
cord-032403-9c1xeqg1	102	4	sectors	sector	NNS
cord-032403-9c1xeqg1	102	5	including	include	VBG
cord-032403-9c1xeqg1	102	6	biopharmaceutical	biopharmaceutical	JJ
cord-032403-9c1xeqg1	102	7	processes	process	NNS
cord-032403-9c1xeqg1	102	8	,	,	,
cord-032403-9c1xeqg1	102	9	process	process	NN
cord-032403-9c1xeqg1	102	10	development	development	NN
cord-032403-9c1xeqg1	102	11	or	or	CC
cord-032403-9c1xeqg1	102	12	operations	operation	NNS
cord-032403-9c1xeqg1	102	13	,	,	,
cord-032403-9c1xeqg1	102	14	teams	team	NNS
cord-032403-9c1xeqg1	102	15	are	be	VBP
cord-032403-9c1xeqg1	102	16	exposed	expose	VBN
cord-032403-9c1xeqg1	102	17	to	to	IN
cord-032403-9c1xeqg1	102	18	new	new	JJ
cord-032403-9c1xeqg1	102	19	entities	entity	NNS
cord-032403-9c1xeqg1	102	20	such	such	JJ
cord-032403-9c1xeqg1	102	21	as	as	IN
cord-032403-9c1xeqg1	102	22	new	new	JJ
cord-032403-9c1xeqg1	102	23	cell	cell	NN
cord-032403-9c1xeqg1	102	24	lines	line	NNS
cord-032403-9c1xeqg1	102	25	to	to	TO
cord-032403-9c1xeqg1	102	26	be	be	VB
cord-032403-9c1xeqg1	102	27	used	use	VBN
cord-032403-9c1xeqg1	102	28	in	in	IN
cord-032403-9c1xeqg1	102	29	the	the	DT
cord-032403-9c1xeqg1	102	30	bioprocess	bioprocess	NN
cord-032403-9c1xeqg1	102	31	,	,	,
cord-032403-9c1xeqg1	102	32	new	new	JJ
cord-032403-9c1xeqg1	102	33	column	column	NN
cord-032403-9c1xeqg1	102	34	material	material	NN
cord-032403-9c1xeqg1	102	35	for	for	IN
cord-032403-9c1xeqg1	102	36	purification	purification	NN
cord-032403-9c1xeqg1	102	37	or	or	CC
cord-032403-9c1xeqg1	102	38	abnormal	abnormal	JJ
cord-032403-9c1xeqg1	102	39	effects	effect	NNS
cord-032403-9c1xeqg1	102	40	such	such	JJ
cord-032403-9c1xeqg1	102	41	as	as	IN
cord-032403-9c1xeqg1	102	42	unusual	unusual	JJ
cord-032403-9c1xeqg1	102	43	levels	level	NNS
cord-032403-9c1xeqg1	102	44	or	or	CC
cord-032403-9c1xeqg1	102	45	profiles	profile	NNS
cord-032403-9c1xeqg1	102	46	of	of	IN
cord-032403-9c1xeqg1	102	47	characteristic	characteristic	JJ
cord-032403-9c1xeqg1	102	48	process	process	NN
cord-032403-9c1xeqg1	102	49	variables	variable	NNS
cord-032403-9c1xeqg1	102	50	in	in	IN
cord-032403-9c1xeqg1	102	51	the	the	DT
cord-032403-9c1xeqg1	102	52	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	102	53	plant	plant	NN
cord-032403-9c1xeqg1	102	54	.	.	.
cord-032403-9c1xeqg1	103	1	Often	often	RB
cord-032403-9c1xeqg1	103	2	,	,	,
cord-032403-9c1xeqg1	103	3	such	such	JJ
cord-032403-9c1xeqg1	103	4	situations	situation	NNS
cord-032403-9c1xeqg1	103	5	must	must	MD
cord-032403-9c1xeqg1	103	6	be	be	VB
cord-032403-9c1xeqg1	103	7	managed	manage	VBN
cord-032403-9c1xeqg1	103	8	under	under	IN
cord-032403-9c1xeqg1	103	9	time	time	NN
cord-032403-9c1xeqg1	103	10	pressure	pressure	NN
cord-032403-9c1xeqg1	103	11	,	,	,
cord-032403-9c1xeqg1	103	12	and	and	CC
cord-032403-9c1xeqg1	103	13	decisions	decision	NNS
cord-032403-9c1xeqg1	103	14	are	be	VBP
cord-032403-9c1xeqg1	103	15	made	make	VBN
cord-032403-9c1xeqg1	103	16	on	on	IN
cord-032403-9c1xeqg1	103	17	the	the	DT
cord-032403-9c1xeqg1	103	18	readily	readily	RB
cord-032403-9c1xeqg1	103	19	available	available	JJ
cord-032403-9c1xeqg1	103	20	data	datum	NNS
cord-032403-9c1xeqg1	103	21	and	and	CC
cord-032403-9c1xeqg1	103	22	best	good	JJS
cord-032403-9c1xeqg1	103	23	educated	educate	VBN
cord-032403-9c1xeqg1	103	24	guesses	guess	NNS
cord-032403-9c1xeqg1	103	25	by	by	IN
cord-032403-9c1xeqg1	103	26	experts	expert	NNS
cord-032403-9c1xeqg1	103	27	.	.	.
cord-032403-9c1xeqg1	104	1	It	-PRON-	PRP
cord-032403-9c1xeqg1	104	2	is	be	VBZ
cord-032403-9c1xeqg1	104	3	an	an	DT
cord-032403-9c1xeqg1	104	4	infrequent	infrequent	JJ
cord-032403-9c1xeqg1	104	5	practice	practice	NN
cord-032403-9c1xeqg1	104	6	to	to	TO
cord-032403-9c1xeqg1	104	7	rigorously	rigorously	RB
cord-032403-9c1xeqg1	104	8	include	include	VB
cord-032403-9c1xeqg1	104	9	any	any	DT
cord-032403-9c1xeqg1	104	10	similar	similar	JJ
cord-032403-9c1xeqg1	104	11	data	datum	NNS
cord-032403-9c1xeqg1	104	12	and	and	CC
cord-032403-9c1xeqg1	104	13	know	know	NN
cord-032403-9c1xeqg1	104	14	-	-	HYPH
cord-032403-9c1xeqg1	104	15	how	how	NN
cord-032403-9c1xeqg1	104	16	from	from	IN
cord-032403-9c1xeqg1	104	17	previous	previous	JJ
cord-032403-9c1xeqg1	104	18	activities	activity	NNS
cord-032403-9c1xeqg1	104	19	directly	directly	RB
cord-032403-9c1xeqg1	104	20	into	into	IN
cord-032403-9c1xeqg1	104	21	the	the	DT
cord-032403-9c1xeqg1	104	22	decision	decision	NN
cord-032403-9c1xeqg1	104	23	process	process	NN
cord-032403-9c1xeqg1	104	24	due	due	JJ
cord-032403-9c1xeqg1	104	25	to	to	IN
cord-032403-9c1xeqg1	104	26	often	often	RB
cord-032403-9c1xeqg1	104	27	severe	severe	JJ
cord-032403-9c1xeqg1	104	28	levels	level	NNS
cord-032403-9c1xeqg1	104	29	of	of	IN
cord-032403-9c1xeqg1	104	30	heterogeneity	heterogeneity	NN
cord-032403-9c1xeqg1	104	31	,	,	,
cord-032403-9c1xeqg1	104	32	which	which	WDT
cord-032403-9c1xeqg1	104	33	can	can	MD
cord-032403-9c1xeqg1	104	34	be	be	VB
cord-032403-9c1xeqg1	104	35	a	a	DT
cord-032403-9c1xeqg1	104	36	result	result	NN
cord-032403-9c1xeqg1	104	37	of	of	IN
cord-032403-9c1xeqg1	104	38	(	(	-LRB-
cord-032403-9c1xeqg1	104	39	partially	partially	RB
cord-032403-9c1xeqg1	104	40	)	)	-RRB-
cord-032403-9c1xeqg1	104	41	different	different	JJ
cord-032403-9c1xeqg1	104	42	utilized	utilize	VBN
cord-032403-9c1xeqg1	104	43	devices	device	NNS
cord-032403-9c1xeqg1	104	44	,	,	,
cord-032403-9c1xeqg1	104	45	scales	scale	NNS
cord-032403-9c1xeqg1	104	46	,	,	,
cord-032403-9c1xeqg1	104	47	and	and	CC
cord-032403-9c1xeqg1	104	48	materials	material	NNS
cord-032403-9c1xeqg1	104	49	as	as	RB
cord-032403-9c1xeqg1	104	50	well	well	RB
cord-032403-9c1xeqg1	104	51	as	as	IN
cord-032403-9c1xeqg1	104	52	differently	differently	RB
cord-032403-9c1xeqg1	104	53	structured	structured	JJ
cord-032403-9c1xeqg1	104	54	or	or	CC
cord-032403-9c1xeqg1	104	55	quantified	quantified	JJ
cord-032403-9c1xeqg1	104	56	data	datum	NNS
cord-032403-9c1xeqg1	104	57	.	.	.
cord-032403-9c1xeqg1	105	1	37	37	CD
cord-032403-9c1xeqg1	106	1	A	a	DT
cord-032403-9c1xeqg1	106	2	smart	smart	JJ
cord-032403-9c1xeqg1	106	3	digital	digital	JJ
cord-032403-9c1xeqg1	106	4	solution	solution	NN
cord-032403-9c1xeqg1	106	5	enabling	enable	VBG
cord-032403-9c1xeqg1	106	6	an	an	DT
cord-032403-9c1xeqg1	106	7	automatic	automatic	JJ
cord-032403-9c1xeqg1	106	8	leverage	leverage	NN
cord-032403-9c1xeqg1	106	9	of	of	IN
cord-032403-9c1xeqg1	106	10	available	available	JJ
cord-032403-9c1xeqg1	106	11	prior	prior	JJ
cord-032403-9c1xeqg1	106	12	information	information	NN
cord-032403-9c1xeqg1	106	13	from	from	IN
cord-032403-9c1xeqg1	106	14	heterogeneous	heterogeneous	JJ
cord-032403-9c1xeqg1	106	15	sources	source	NNS
cord-032403-9c1xeqg1	106	16	by	by	IN
cord-032403-9c1xeqg1	106	17	reliably	reliably	RB
cord-032403-9c1xeqg1	106	18	deducing	deduce	VBG
cord-032403-9c1xeqg1	106	19	the	the	DT
cord-032403-9c1xeqg1	106	20	transferrable	transferrable	JJ
cord-032403-9c1xeqg1	106	21	know	know	NN
cord-032403-9c1xeqg1	106	22	-	-	HYPH
cord-032403-9c1xeqg1	106	23	how	how	WRB
cord-032403-9c1xeqg1	106	24	could	could	MD
cord-032403-9c1xeqg1	106	25	enable	enable	VB
cord-032403-9c1xeqg1	106	26	a	a	DT
cord-032403-9c1xeqg1	106	27	tremendous	tremendous	JJ
cord-032403-9c1xeqg1	106	28	breakthrough	breakthrough	NN
cord-032403-9c1xeqg1	106	29	for	for	IN
cord-032403-9c1xeqg1	106	30	supporting	support	VBG
cord-032403-9c1xeqg1	106	31	complex	complex	JJ
cord-032403-9c1xeqg1	106	32	decision	decision	NN
cord-032403-9c1xeqg1	106	33	making	make	VBG
cord-032403-9c1xeqg1	106	34	in	in	IN
cord-032403-9c1xeqg1	106	35	biopharma	biopharma	NN
cord-032403-9c1xeqg1	106	36	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	106	37	.	.	.
cord-032403-9c1xeqg1	107	1	38	38	CD
cord-032403-9c1xeqg1	108	1	The	the	DT
cord-032403-9c1xeqg1	108	2	general	general	JJ
cord-032403-9c1xeqg1	108	3	structure	structure	NN
cord-032403-9c1xeqg1	108	4	of	of	IN
cord-032403-9c1xeqg1	108	5	hybrid	hybrid	JJ
cord-032403-9c1xeqg1	108	6	models	model	NNS
cord-032403-9c1xeqg1	108	7	is	be	VBZ
cord-032403-9c1xeqg1	108	8	quite	quite	RB
cord-032403-9c1xeqg1	108	9	attractive	attractive	JJ
cord-032403-9c1xeqg1	108	10	to	to	TO
cord-032403-9c1xeqg1	108	11	apply	apply	VB
cord-032403-9c1xeqg1	108	12	such	such	JJ
cord-032403-9c1xeqg1	108	13	transfer	transfer	NN
cord-032403-9c1xeqg1	108	14	learning	learning	NN
cord-032403-9c1xeqg1	108	15	concept	concept	NN
cord-032403-9c1xeqg1	108	16	in	in	IN
cord-032403-9c1xeqg1	108	17	small	small	JJ
cord-032403-9c1xeqg1	108	18	data	datum	NNS
cord-032403-9c1xeqg1	108	19	environments	environment	NNS
cord-032403-9c1xeqg1	108	20	,	,	,
cord-032403-9c1xeqg1	108	21	where	where	WRB
cord-032403-9c1xeqg1	108	22	the	the	DT
cord-032403-9c1xeqg1	108	23	mechanistic	mechanistic	JJ
cord-032403-9c1xeqg1	108	24	backbone	backbone	NN
cord-032403-9c1xeqg1	108	25	accounts	account	VBZ
cord-032403-9c1xeqg1	108	26	for	for	IN
cord-032403-9c1xeqg1	108	27	major	major	JJ
cord-032403-9c1xeqg1	108	28	generic	generic	JJ
cord-032403-9c1xeqg1	108	29	effects	effect	NNS
cord-032403-9c1xeqg1	108	30	while	while	IN
cord-032403-9c1xeqg1	108	31	the	the	DT
cord-032403-9c1xeqg1	108	32	machine	machine	NN
cord-032403-9c1xeqg1	108	33	learning	learn	VBG
cord-032403-9c1xeqg1	108	34	part	part	NN
cord-032403-9c1xeqg1	108	35	enables	enable	VBZ
cord-032403-9c1xeqg1	108	36	fine	fine	RB
cord-032403-9c1xeqg1	108	37	-	-	HYPH
cord-032403-9c1xeqg1	108	38	tuning	tuning	NN
cord-032403-9c1xeqg1	108	39	based	base	VBN
cord-032403-9c1xeqg1	108	40	on	on	IN
cord-032403-9c1xeqg1	108	41	the	the	DT
cord-032403-9c1xeqg1	108	42	limited	limit	VBN
cord-032403-9c1xeqg1	108	43	available	available	JJ
cord-032403-9c1xeqg1	108	44	data	datum	NNS
cord-032403-9c1xeqg1	108	45	,	,	,
cord-032403-9c1xeqg1	108	46	for	for	IN
cord-032403-9c1xeqg1	108	47	instance	instance	NN
cord-032403-9c1xeqg1	108	48	to	to	IN
cord-032403-9c1xeqg1	108	49	a	a	DT
cord-032403-9c1xeqg1	108	50	specific	specific	JJ
cord-032403-9c1xeqg1	108	51	molecule	molecule	NN
cord-032403-9c1xeqg1	108	52	.	.	.
cord-032403-9c1xeqg1	109	1	In	in	IN
cord-032403-9c1xeqg1	109	2	process	process	NN
cord-032403-9c1xeqg1	109	3	development	development	NN
cord-032403-9c1xeqg1	109	4	such	such	PDT
cord-032403-9c1xeqg1	109	5	an	an	DT
cord-032403-9c1xeqg1	109	6	approach	approach	NN
cord-032403-9c1xeqg1	109	7	capitalizes	capitalize	VBZ
cord-032403-9c1xeqg1	109	8	strongly	strongly	RB
cord-032403-9c1xeqg1	109	9	on	on	IN
cord-032403-9c1xeqg1	109	10	all	all	DT
cord-032403-9c1xeqg1	109	11	available	available	JJ
cord-032403-9c1xeqg1	109	12	information	information	NN
cord-032403-9c1xeqg1	109	13	from	from	IN
cord-032403-9c1xeqg1	109	14	previous	previous	JJ
cord-032403-9c1xeqg1	109	15	development	development	NN
cord-032403-9c1xeqg1	109	16	activities	activity	NNS
cord-032403-9c1xeqg1	109	17	.	.	.
cord-032403-9c1xeqg1	110	1	This	this	DT
cord-032403-9c1xeqg1	110	2	could	could	MD
cord-032403-9c1xeqg1	110	3	not	not	RB
cord-032403-9c1xeqg1	110	4	only	only	RB
cord-032403-9c1xeqg1	110	5	support	support	VB
cord-032403-9c1xeqg1	110	6	pharma	pharma	NNS
cord-032403-9c1xeqg1	110	7	companies	company	NNS
cord-032403-9c1xeqg1	110	8	,	,	,
cord-032403-9c1xeqg1	110	9	but	but	CC
cord-032403-9c1xeqg1	110	10	particularly	particularly	RB
cord-032403-9c1xeqg1	110	11	also	also	RB
cord-032403-9c1xeqg1	110	12	customer	customer	NN
cord-032403-9c1xeqg1	110	13	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	110	14	organizations	organization	NNS
cord-032403-9c1xeqg1	110	15	(	(	-LRB-
cord-032403-9c1xeqg1	110	16	CMOs	CMOs	NNPS
cord-032403-9c1xeqg1	110	17	)	)	-RRB-
cord-032403-9c1xeqg1	110	18	the	the	DT
cord-032403-9c1xeqg1	110	19	business	business	NN
cord-032403-9c1xeqg1	110	20	model	model	NN
cord-032403-9c1xeqg1	110	21	of	of	IN
cord-032403-9c1xeqg1	110	22	which	which	WDT
cord-032403-9c1xeqg1	110	23	scales	scale	VBZ
cord-032403-9c1xeqg1	110	24	even	even	RB
cord-032403-9c1xeqg1	110	25	more	more	RBR
cord-032403-9c1xeqg1	110	26	with	with	IN
cord-032403-9c1xeqg1	110	27	delivering	deliver	VBG
cord-032403-9c1xeqg1	110	28	on	on	IN
cord-032403-9c1xeqg1	110	29	time	time	NN
cord-032403-9c1xeqg1	110	30	,	,	,
cord-032403-9c1xeqg1	110	31	and	and	CC
cord-032403-9c1xeqg1	110	32	which	which	WDT
cord-032403-9c1xeqg1	110	33	are	be	VBP
cord-032403-9c1xeqg1	110	34	exposed	expose	VBN
cord-032403-9c1xeqg1	110	35	to	to	IN
cord-032403-9c1xeqg1	110	36	a	a	DT
cord-032403-9c1xeqg1	110	37	large	large	JJ
cord-032403-9c1xeqg1	110	38	level	level	NN
cord-032403-9c1xeqg1	110	39	of	of	IN
cord-032403-9c1xeqg1	110	40	diversity	diversity	NN
cord-032403-9c1xeqg1	110	41	.	.	.
cord-032403-9c1xeqg1	111	1	Of	of	RB
cord-032403-9c1xeqg1	111	2	course	course	RB
cord-032403-9c1xeqg1	111	3	,	,	,
cord-032403-9c1xeqg1	111	4	a	a	DT
cord-032403-9c1xeqg1	111	5	beneficial	beneficial	JJ
cord-032403-9c1xeqg1	111	6	implementation	implementation	NN
cord-032403-9c1xeqg1	111	7	of	of	IN
cord-032403-9c1xeqg1	111	8	broadly	broadly	RB
cord-032403-9c1xeqg1	111	9	applicable	applicable	JJ
cord-032403-9c1xeqg1	111	10	transfer	transfer	NN
cord-032403-9c1xeqg1	111	11	learning	learning	NN
cord-032403-9c1xeqg1	111	12	must	must	MD
cord-032403-9c1xeqg1	111	13	go	go	VB
cord-032403-9c1xeqg1	111	14	through	through	IN
cord-032403-9c1xeqg1	111	15	a	a	DT
cord-032403-9c1xeqg1	111	16	rigorous	rigorous	JJ
cord-032403-9c1xeqg1	111	17	digitalization	digitalization	NN
cord-032403-9c1xeqg1	111	18	and	and	CC
cord-032403-9c1xeqg1	111	19	integration	integration	NN
cord-032403-9c1xeqg1	111	20	of	of	IN
cord-032403-9c1xeqg1	111	21	all	all	DT
cord-032403-9c1xeqg1	111	22	data	datum	NNS
cord-032403-9c1xeqg1	111	23	archives	archive	NNS
cord-032403-9c1xeqg1	111	24	,	,	,
cord-032403-9c1xeqg1	111	25	39	39	CD
cord-032403-9c1xeqg1	111	26	which	which	WDT
cord-032403-9c1xeqg1	111	27	requires	require	VBZ
cord-032403-9c1xeqg1	111	28	a	a	DT
cord-032403-9c1xeqg1	111	29	tremendous	tremendous	JJ
cord-032403-9c1xeqg1	111	30	preparation	preparation	NN
cord-032403-9c1xeqg1	111	31	and	and	CC
cord-032403-9c1xeqg1	111	32	investment	investment	NN
cord-032403-9c1xeqg1	111	33	.	.	.
cord-032403-9c1xeqg1	112	1	40	40	CD
cord-032403-9c1xeqg1	112	2	Other	other	JJ
cord-032403-9c1xeqg1	112	3	industries	industry	NNS
cord-032403-9c1xeqg1	112	4	such	such	JJ
cord-032403-9c1xeqg1	112	5	as	as	IN
cord-032403-9c1xeqg1	112	6	finance	finance	NN
cord-032403-9c1xeqg1	112	7	have	have	VBP
cord-032403-9c1xeqg1	112	8	demonstrated	demonstrate	VBN
cord-032403-9c1xeqg1	112	9	the	the	DT
cord-032403-9c1xeqg1	112	10	impact	impact	NN
cord-032403-9c1xeqg1	112	11	and	and	CC
cord-032403-9c1xeqg1	112	12	potential	potential	NN
cord-032403-9c1xeqg1	112	13	of	of	IN
cord-032403-9c1xeqg1	112	14	such	such	JJ
cord-032403-9c1xeqg1	112	15	digital	digital	JJ
cord-032403-9c1xeqg1	112	16	transformation	transformation	NN
cord-032403-9c1xeqg1	112	17	.	.	.
cord-032403-9c1xeqg1	113	1	41	41	CD
cord-032403-9c1xeqg1	114	1	Although	although	IN
cord-032403-9c1xeqg1	114	2	hybrid	hybrid	JJ
cord-032403-9c1xeqg1	114	3	modeling	modeling	NN
cord-032403-9c1xeqg1	114	4	has	have	VBZ
cord-032403-9c1xeqg1	114	5	not	not	RB
cord-032403-9c1xeqg1	114	6	been	be	VBN
cord-032403-9c1xeqg1	114	7	reported	report	VBN
cord-032403-9c1xeqg1	114	8	in	in	IN
cord-032403-9c1xeqg1	114	9	direct	direct	JJ
cord-032403-9c1xeqg1	114	10	connection	connection	NN
cord-032403-9c1xeqg1	114	11	with	with	IN
cord-032403-9c1xeqg1	114	12	transfer	transfer	NN
cord-032403-9c1xeqg1	114	13	learning	learn	VBG
cord-032403-9c1xeqg1	114	14	in	in	IN
cord-032403-9c1xeqg1	114	15	biomanufacturing	biomanufacture	VBG
cord-032403-9c1xeqg1	114	16	,	,	,
cord-032403-9c1xeqg1	114	17	several	several	JJ
cord-032403-9c1xeqg1	114	18	transfer	transfer	NN
cord-032403-9c1xeqg1	114	19	use	use	NN
cord-032403-9c1xeqg1	114	20	cases	case	NNS
cord-032403-9c1xeqg1	114	21	based	base	VBN
cord-032403-9c1xeqg1	114	22	on	on	IN
cord-032403-9c1xeqg1	114	23	datadriven	datadriven	JJ
cord-032403-9c1xeqg1	114	24	techniques	technique	NNS
cord-032403-9c1xeqg1	114	25	have	have	VBP
cord-032403-9c1xeqg1	114	26	been	be	VBN
cord-032403-9c1xeqg1	114	27	already	already	RB
cord-032403-9c1xeqg1	114	28	conducted	conduct	VBN
cord-032403-9c1xeqg1	114	29	to	to	TO
cord-032403-9c1xeqg1	114	30	further	further	RB
cord-032403-9c1xeqg1	114	31	explore	explore	VB
cord-032403-9c1xeqg1	114	32	and	and	CC
cord-032403-9c1xeqg1	114	33	adapt	adapt	VB
cord-032403-9c1xeqg1	114	34	model	model	NN
cord-032403-9c1xeqg1	114	35	-	-	HYPH
cord-032403-9c1xeqg1	114	36	supported	support	VBN
cord-032403-9c1xeqg1	114	37	transfer	transfer	NN
cord-032403-9c1xeqg1	114	38	learning	learn	VBG
cord-032403-9c1xeqg1	114	39	in	in	IN
cord-032403-9c1xeqg1	114	40	biopharma	biopharma	NNS
cord-032403-9c1xeqg1	114	41	.	.	.
cord-032403-9c1xeqg1	115	1	Examples	example	NNS
cord-032403-9c1xeqg1	115	2	include	include	VBP
cord-032403-9c1xeqg1	115	3	extrapolation	extrapolation	NN
cord-032403-9c1xeqg1	115	4	from	from	IN
cord-032403-9c1xeqg1	115	5	low	low	JJ
cord-032403-9c1xeqg1	115	6	to	to	IN
cord-032403-9c1xeqg1	115	7	high	high	JJ
cord-032403-9c1xeqg1	115	8	performing	perform	VBG
cord-032403-9c1xeqg1	115	9	conditions	condition	NNS
cord-032403-9c1xeqg1	115	10	with	with	IN
cord-032403-9c1xeqg1	115	11	hybrid	hybrid	JJ
cord-032403-9c1xeqg1	115	12	models	model	NNS
cord-032403-9c1xeqg1	115	13	,	,	,
cord-032403-9c1xeqg1	115	14	18	18	CD
cord-032403-9c1xeqg1	115	15	cross	cross	JJ
cord-032403-9c1xeqg1	115	16	-	-	JJ
cord-032403-9c1xeqg1	115	17	scale	scale	JJ
cord-032403-9c1xeqg1	115	18	prediction	prediction	NN
cord-032403-9c1xeqg1	115	19	,	,	,
cord-032403-9c1xeqg1	115	20	and	and	CC
cord-032403-9c1xeqg1	115	21	cross	cross	JJ
cord-032403-9c1xeqg1	115	22	-	-	JJ
cord-032403-9c1xeqg1	115	23	molecule	molecule	JJ
cord-032403-9c1xeqg1	115	24	prediction	prediction	NN
cord-032403-9c1xeqg1	115	25	with	with	IN
cord-032403-9c1xeqg1	115	26	multivariate	multivariate	JJ
cord-032403-9c1xeqg1	115	27	42−44	42−44	CD
cord-032403-9c1xeqg1	115	28	and	and	CC
cord-032403-9c1xeqg1	115	29	with	with	IN
cord-032403-9c1xeqg1	115	30	adaptive	adaptive	JJ
cord-032403-9c1xeqg1	115	31	machine	machine	NN
cord-032403-9c1xeqg1	115	32	learning	learning	NN
cord-032403-9c1xeqg1	115	33	techniques	technique	NNS
cord-032403-9c1xeqg1	115	34	.	.	.
cord-032403-9c1xeqg1	116	1	45	45	CD
cord-032403-9c1xeqg1	116	2	 	 	_SP
cord-032403-9c1xeqg1	117	1	It	-PRON-	PRP
cord-032403-9c1xeqg1	117	2	goes	go	VBZ
cord-032403-9c1xeqg1	117	3	without	without	IN
cord-032403-9c1xeqg1	117	4	saying	say	VBG
cord-032403-9c1xeqg1	117	5	that	that	IN
cord-032403-9c1xeqg1	117	6	,	,	,
cord-032403-9c1xeqg1	117	7	in	in	IN
cord-032403-9c1xeqg1	117	8	a	a	DT
cord-032403-9c1xeqg1	117	9	situation	situation	NN
cord-032403-9c1xeqg1	117	10	such	such	JJ
cord-032403-9c1xeqg1	117	11	as	as	IN
cord-032403-9c1xeqg1	117	12	the	the	DT
cord-032403-9c1xeqg1	117	13	Covid-19	Covid-19	NNP
cord-032403-9c1xeqg1	117	14	pandemic	pandemic	NN
cord-032403-9c1xeqg1	117	15	,	,	,
cord-032403-9c1xeqg1	117	16	a	a	DT
cord-032403-9c1xeqg1	117	17	trustworthy	trustworthy	JJ
cord-032403-9c1xeqg1	117	18	forecast	forecast	NN
cord-032403-9c1xeqg1	117	19	of	of	IN
cord-032403-9c1xeqg1	117	20	the	the	DT
cord-032403-9c1xeqg1	117	21	near	near	JJ
cord-032403-9c1xeqg1	117	22	future	future	NN
cord-032403-9c1xeqg1	117	23	would	would	MD
cord-032403-9c1xeqg1	117	24	be	be	VB
cord-032403-9c1xeqg1	117	25	priceless	priceless	JJ
cord-032403-9c1xeqg1	117	26	.	.	.
cord-032403-9c1xeqg1	118	1	Thereby	thereby	RB
cord-032403-9c1xeqg1	118	2	,	,	,
cord-032403-9c1xeqg1	118	3	one	one	PRP
cord-032403-9c1xeqg1	118	4	has	have	VBZ
cord-032403-9c1xeqg1	118	5	to	to	TO
cord-032403-9c1xeqg1	118	6	comment	comment	VB
cord-032403-9c1xeqg1	118	7	that	that	IN
cord-032403-9c1xeqg1	118	8	it	-PRON-	PRP
cord-032403-9c1xeqg1	118	9	is	be	VBZ
cord-032403-9c1xeqg1	118	10	not	not	RB
cord-032403-9c1xeqg1	118	11	only	only	RB
cord-032403-9c1xeqg1	118	12	the	the	DT
cord-032403-9c1xeqg1	118	13	knowledge	knowledge	NN
cord-032403-9c1xeqg1	118	14	of	of	IN
cord-032403-9c1xeqg1	118	15	the	the	DT
cord-032403-9c1xeqg1	118	16	future	future	JJ
cord-032403-9c1xeqg1	118	17	evolution	evolution	NN
cord-032403-9c1xeqg1	118	18	that	that	WDT
cord-032403-9c1xeqg1	118	19	counts	count	VBZ
cord-032403-9c1xeqg1	118	20	but	but	CC
cord-032403-9c1xeqg1	118	21	also	also	RB
cord-032403-9c1xeqg1	118	22	the	the	DT
cord-032403-9c1xeqg1	118	23	underlying	underlie	VBG
cord-032403-9c1xeqg1	118	24	understanding	understanding	NN
cord-032403-9c1xeqg1	118	25	on	on	IN
cord-032403-9c1xeqg1	118	26	its	-PRON-	PRP$
cord-032403-9c1xeqg1	118	27	relation	relation	NN
cord-032403-9c1xeqg1	118	28	to	to	IN
cord-032403-9c1xeqg1	118	29	the	the	DT
cord-032403-9c1xeqg1	118	30	introduced	introduce	VBN
cord-032403-9c1xeqg1	118	31	regulations	regulation	NNS
cord-032403-9c1xeqg1	118	32	.	.	.
cord-032403-9c1xeqg1	119	1	This	this	DT
cord-032403-9c1xeqg1	119	2	understanding	understanding	NN
cord-032403-9c1xeqg1	119	3	is	be	VBZ
cord-032403-9c1xeqg1	119	4	vital	vital	JJ
cord-032403-9c1xeqg1	119	5	to	to	TO
cord-032403-9c1xeqg1	119	6	make	make	VB
cord-032403-9c1xeqg1	119	7	a	a	DT
cord-032403-9c1xeqg1	119	8	solid	solid	JJ
cord-032403-9c1xeqg1	119	9	decision	decision	NN
cord-032403-9c1xeqg1	119	10	among	among	IN
cord-032403-9c1xeqg1	119	11	many	many	JJ
cord-032403-9c1xeqg1	119	12	potential	potential	JJ
cord-032403-9c1xeqg1	119	13	alternatives	alternative	NNS
cord-032403-9c1xeqg1	119	14	.	.	.
cord-032403-9c1xeqg1	120	1	Hence	hence	RB
cord-032403-9c1xeqg1	120	2	,	,	,
cord-032403-9c1xeqg1	120	3	taking	take	VBG
cord-032403-9c1xeqg1	120	4	the	the	DT
cord-032403-9c1xeqg1	120	5	definitions	definition	NNS
cord-032403-9c1xeqg1	120	6	in	in	IN
cord-032403-9c1xeqg1	120	7	Figure	figure	NN
cord-032403-9c1xeqg1	120	8	3	3	CD
cord-032403-9c1xeqg1	120	9	,	,	,
cord-032403-9c1xeqg1	120	10	at	at	IN
cord-032403-9c1xeqg1	120	11	each	each	DT
cord-032403-9c1xeqg1	120	12	point	point	NN
cord-032403-9c1xeqg1	120	13	of	of	IN
cord-032403-9c1xeqg1	120	14	time	time	NN
cord-032403-9c1xeqg1	120	15	one	one	PRP
cord-032403-9c1xeqg1	120	16	would	would	MD
cord-032403-9c1xeqg1	120	17	like	like	VB
cord-032403-9c1xeqg1	120	18	to	to	TO
cord-032403-9c1xeqg1	120	19	understand	understand	VB
cord-032403-9c1xeqg1	120	20	how	how	WRB
cord-032403-9c1xeqg1	120	21	changes	change	NNS
cord-032403-9c1xeqg1	120	22	in	in	IN
cord-032403-9c1xeqg1	120	23	Z	z	NN
cord-032403-9c1xeqg1	120	24	affect	affect	VBP
cord-032403-9c1xeqg1	120	25	the	the	DT
cord-032403-9c1xeqg1	120	26	process	process	NN
cord-032403-9c1xeqg1	120	27	outcome	outcome	NN
cord-032403-9c1xeqg1	120	28	Y	Y	NNP
cord-032403-9c1xeqg1	120	29	,	,	,
cord-032403-9c1xeqg1	120	30	and	and	CC
cord-032403-9c1xeqg1	120	31	which	which	WDT
cord-032403-9c1xeqg1	120	32	combination	combination	NN
cord-032403-9c1xeqg1	120	33	of	of	IN
cord-032403-9c1xeqg1	120	34	Z	Z	NNP
cord-032403-9c1xeqg1	120	35	is	be	VBZ
cord-032403-9c1xeqg1	120	36	optimal	optimal	JJ
cord-032403-9c1xeqg1	120	37	to	to	TO
cord-032403-9c1xeqg1	120	38	reach	reach	VB
cord-032403-9c1xeqg1	120	39	the	the	DT
cord-032403-9c1xeqg1	120	40	desired	desire	VBN
cord-032403-9c1xeqg1	120	41	outcome	outcome	NN
cord-032403-9c1xeqg1	120	42	Y	Y	NNP
cord-032403-9c1xeqg1	120	43	optimal	optimal	JJ
cord-032403-9c1xeqg1	120	44	.	.	.
cord-032403-9c1xeqg1	121	1	While	while	IN
cord-032403-9c1xeqg1	121	2	this	this	DT
cord-032403-9c1xeqg1	121	3	theoretically	theoretically	RB
cord-032403-9c1xeqg1	121	4	represents	represent	VBZ
cord-032403-9c1xeqg1	121	5	a	a	DT
cord-032403-9c1xeqg1	121	6	classical	classical	JJ
cord-032403-9c1xeqg1	121	7	optimization	optimization	NN
cord-032403-9c1xeqg1	121	8	problem	problem	NN
cord-032403-9c1xeqg1	121	9	,	,	,
cord-032403-9c1xeqg1	121	10	in	in	IN
cord-032403-9c1xeqg1	121	11	the	the	DT
cord-032403-9c1xeqg1	121	12	process	process	NN
cord-032403-9c1xeqg1	121	13	development	development	NN
cord-032403-9c1xeqg1	121	14	lab	lab	NN
cord-032403-9c1xeqg1	121	15	and	and	CC
cord-032403-9c1xeqg1	121	16	on	on	IN
cord-032403-9c1xeqg1	121	17	the	the	DT
cord-032403-9c1xeqg1	121	18	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	121	19	floor	floor	NN
cord-032403-9c1xeqg1	121	20	,	,	,
cord-032403-9c1xeqg1	121	21	the	the	DT
cord-032403-9c1xeqg1	121	22	different	different	JJ
cord-032403-9c1xeqg1	121	23	teams	team	NNS
cord-032403-9c1xeqg1	121	24	require	require	VBP
cord-032403-9c1xeqg1	121	25	a	a	DT
cord-032403-9c1xeqg1	121	26	practically	practically	RB
cord-032403-9c1xeqg1	121	27	relevant	relevant	JJ
cord-032403-9c1xeqg1	121	28	representation	representation	NN
cord-032403-9c1xeqg1	121	29	of	of	IN
cord-032403-9c1xeqg1	121	30	such	such	PDT
cord-032403-9c1xeqg1	121	31	a	a	DT
cord-032403-9c1xeqg1	121	32	solution	solution	NN
cord-032403-9c1xeqg1	121	33	which	which	WDT
cord-032403-9c1xeqg1	121	34	is	be	VBZ
cord-032403-9c1xeqg1	121	35	connected	connect	VBN
cord-032403-9c1xeqg1	121	36	as	as	RB
cord-032403-9c1xeqg1	121	37	much	much	RB
cord-032403-9c1xeqg1	121	38	as	as	IN
cord-032403-9c1xeqg1	121	39	possible	possible	JJ
cord-032403-9c1xeqg1	121	40	to	to	IN
cord-032403-9c1xeqg1	121	41	their	-PRON-	PRP$
cord-032403-9c1xeqg1	121	42	daily	daily	JJ
cord-032403-9c1xeqg1	121	43	workstream	workstream	NN
cord-032403-9c1xeqg1	121	44	and	and	CC
cord-032403-9c1xeqg1	121	45	mindset	mindset	NN
cord-032403-9c1xeqg1	121	46	as	as	RB
cord-032403-9c1xeqg1	121	47	well	well	RB
cord-032403-9c1xeqg1	121	48	as	as	IN
cord-032403-9c1xeqg1	121	49	associated	associate	VBN
cord-032403-9c1xeqg1	121	50	decision	decision	NN
cord-032403-9c1xeqg1	121	51	making	making	NN
cord-032403-9c1xeqg1	121	52	process	process	NN
cord-032403-9c1xeqg1	121	53	.	.	.
cord-032403-9c1xeqg1	122	1	The	the	DT
cord-032403-9c1xeqg1	122	2	possibility	possibility	NN
cord-032403-9c1xeqg1	122	3	to	to	TO
cord-032403-9c1xeqg1	122	4	simulate	simulate	VB
cord-032403-9c1xeqg1	122	5	different	different	JJ
cord-032403-9c1xeqg1	122	6	future	future	JJ
cord-032403-9c1xeqg1	122	7	scenarios	scenario	NNS
cord-032403-9c1xeqg1	122	8	and	and	CC
cord-032403-9c1xeqg1	122	9	compare	compare	VB
cord-032403-9c1xeqg1	122	10	the	the	DT
cord-032403-9c1xeqg1	122	11	results	result	NNS
cord-032403-9c1xeqg1	122	12	must	must	MD
cord-032403-9c1xeqg1	122	13	therefore	therefore	RB
cord-032403-9c1xeqg1	122	14	be	be	VB
cord-032403-9c1xeqg1	122	15	presented	present	VBN
cord-032403-9c1xeqg1	122	16	in	in	IN
cord-032403-9c1xeqg1	122	17	a	a	DT
cord-032403-9c1xeqg1	122	18	visually	visually	RB
cord-032403-9c1xeqg1	122	19	comprehensible	comprehensible	JJ
cord-032403-9c1xeqg1	122	20	,	,	,
cord-032403-9c1xeqg1	122	21	tangible	tangible	JJ
cord-032403-9c1xeqg1	122	22	,	,	,
cord-032403-9c1xeqg1	122	23	manageable	manageable	JJ
cord-032403-9c1xeqg1	122	24	,	,	,
cord-032403-9c1xeqg1	122	25	and	and	CC
cord-032403-9c1xeqg1	122	26	transferrable	transferrable	JJ
cord-032403-9c1xeqg1	122	27	form	form	NN
cord-032403-9c1xeqg1	122	28	.	.	.
cord-032403-9c1xeqg1	123	1	Figure	figure	NN
cord-032403-9c1xeqg1	123	2	4	4	CD
cord-032403-9c1xeqg1	123	3	presents	present	VBZ
cord-032403-9c1xeqg1	123	4	the	the	DT
cord-032403-9c1xeqg1	123	5	added	add	VBN
cord-032403-9c1xeqg1	123	6	value	value	NN
cord-032403-9c1xeqg1	123	7	generated	generate	VBN
cord-032403-9c1xeqg1	123	8	by	by	IN
cord-032403-9c1xeqg1	123	9	different	different	JJ
cord-032403-9c1xeqg1	123	10	levels	level	NNS
cord-032403-9c1xeqg1	123	11	of	of	IN
cord-032403-9c1xeqg1	123	12	technological	technological	JJ
cord-032403-9c1xeqg1	123	13	complexity	complexity	NN
cord-032403-9c1xeqg1	123	14	and	and	CC
cord-032403-9c1xeqg1	123	15	integration	integration	NN
cord-032403-9c1xeqg1	123	16	of	of	IN
cord-032403-9c1xeqg1	123	17	digital	digital	JJ
cord-032403-9c1xeqg1	123	18	solutions	solution	NNS
cord-032403-9c1xeqg1	123	19	in	in	IN
cord-032403-9c1xeqg1	123	20	biopharmaceutical	biopharmaceutical	JJ
cord-032403-9c1xeqg1	123	21	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	123	22	.	.	.
cord-032403-9c1xeqg1	124	1	As	as	IN
cord-032403-9c1xeqg1	124	2	highlighted	highlight	VBN
cord-032403-9c1xeqg1	124	3	in	in	IN
cord-032403-9c1xeqg1	124	4	Figure	Figure	NNP
cord-032403-9c1xeqg1	124	5	4	4	CD
cord-032403-9c1xeqg1	124	6	,	,	,
cord-032403-9c1xeqg1	124	7	even	even	RB
cord-032403-9c1xeqg1	124	8	further	further	JJ
cord-032403-9c1xeqg1	124	9	value	value	NN
cord-032403-9c1xeqg1	124	10	can	can	MD
cord-032403-9c1xeqg1	124	11	be	be	VB
cord-032403-9c1xeqg1	124	12	created	create	VBN
cord-032403-9c1xeqg1	124	13	not	not	RB
cord-032403-9c1xeqg1	124	14	only	only	RB
cord-032403-9c1xeqg1	124	15	if	if	IN
cord-032403-9c1xeqg1	124	16	the	the	DT
cord-032403-9c1xeqg1	124	17	potential	potential	NN
cord-032403-9c1xeqg1	124	18	of	of	IN
cord-032403-9c1xeqg1	124	19	hybrid	hybrid	JJ
cord-032403-9c1xeqg1	124	20	modeling	modeling	NN
cord-032403-9c1xeqg1	124	21	and	and	CC
cord-032403-9c1xeqg1	124	22	transfer	transfer	NN
cord-032403-9c1xeqg1	124	23	learning	learning	NN
cord-032403-9c1xeqg1	124	24	is	be	VBZ
cord-032403-9c1xeqg1	124	25	assessable	assessable	JJ
cord-032403-9c1xeqg1	124	26	through	through	IN
cord-032403-9c1xeqg1	124	27	a	a	DT
cord-032403-9c1xeqg1	124	28	practically	practically	RB
cord-032403-9c1xeqg1	124	29	designed	design	VBN
cord-032403-9c1xeqg1	124	30	digital	digital	JJ
cord-032403-9c1xeqg1	124	31	twin	twin	NN
cord-032403-9c1xeqg1	124	32	but	but	CC
cord-032403-9c1xeqg1	124	33	also	also	RB
cord-032403-9c1xeqg1	124	34	if	if	IN
cord-032403-9c1xeqg1	124	35	such	such	PDT
cord-032403-9c1xeqg1	124	36	a	a	DT
cord-032403-9c1xeqg1	124	37	digital	digital	JJ
cord-032403-9c1xeqg1	124	38	twin	twin	NN
cord-032403-9c1xeqg1	124	39	is	be	VBZ
cord-032403-9c1xeqg1	124	40	directly	directly	RB
cord-032403-9c1xeqg1	124	41	connected	connect	VBN
cord-032403-9c1xeqg1	124	42	to	to	IN
cord-032403-9c1xeqg1	124	43	the	the	DT
cord-032403-9c1xeqg1	124	44	process	process	NN
cord-032403-9c1xeqg1	124	45	and	and	CC
cord-032403-9c1xeqg1	124	46	becomes	become	VBZ
cord-032403-9c1xeqg1	124	47	an	an	DT
cord-032403-9c1xeqg1	124	48	active	active	JJ
cord-032403-9c1xeqg1	124	49	stakeholder	stakeholder	NN
cord-032403-9c1xeqg1	124	50	of	of	IN
cord-032403-9c1xeqg1	124	51	the	the	DT
cord-032403-9c1xeqg1	124	52	decision	decision	NN
cord-032403-9c1xeqg1	124	53	making	make	VBG
cord-032403-9c1xeqg1	124	54	process	process	NN
cord-032403-9c1xeqg1	124	55	.	.	.
cord-032403-9c1xeqg1	125	1	46	46	CD
cord-032403-9c1xeqg1	126	1	Being	be	VBG
cord-032403-9c1xeqg1	126	2	set	set	VBN
cord-032403-9c1xeqg1	126	3	up	up	RP
cord-032403-9c1xeqg1	126	4	in	in	IN
cord-032403-9c1xeqg1	126	5	real	real	JJ
cord-032403-9c1xeqg1	126	6	-	-	HYPH
cord-032403-9c1xeqg1	126	7	time	time	NN
cord-032403-9c1xeqg1	126	8	connection	connection	NN
cord-032403-9c1xeqg1	126	9	to	to	IN
cord-032403-9c1xeqg1	126	10	all	all	DT
cord-032403-9c1xeqg1	126	11	data	datum	NNS
cord-032403-9c1xeqg1	126	12	generating	generate	VBG
cord-032403-9c1xeqg1	126	13	devices	device	NNS
cord-032403-9c1xeqg1	126	14	,	,	,
cord-032403-9c1xeqg1	126	15	all	all	DT
cord-032403-9c1xeqg1	126	16	accessible	accessible	JJ
cord-032403-9c1xeqg1	126	17	and	and	CC
cord-032403-9c1xeqg1	126	18	consistently	consistently	RB
cord-032403-9c1xeqg1	126	19	learning	learn	VBG
cord-032403-9c1xeqg1	126	20	models	model	NNS
cord-032403-9c1xeqg1	126	21	,	,	,
cord-032403-9c1xeqg1	126	22	and	and	CC
cord-032403-9c1xeqg1	126	23	the	the	DT
cord-032403-9c1xeqg1	126	24	process	process	NN
cord-032403-9c1xeqg1	126	25	control	control	NN
cord-032403-9c1xeqg1	126	26	layer	layer	NN
cord-032403-9c1xeqg1	126	27	,	,	,
cord-032403-9c1xeqg1	126	28	such	such	PDT
cord-032403-9c1xeqg1	126	29	a	a	DT
cord-032403-9c1xeqg1	126	30	digital	digital	JJ
cord-032403-9c1xeqg1	126	31	twin	twin	NN
cord-032403-9c1xeqg1	126	32	can	can	MD
cord-032403-9c1xeqg1	126	33	not	not	RB
cord-032403-9c1xeqg1	126	34	only	only	RB
cord-032403-9c1xeqg1	126	35	provide	provide	VB
cord-032403-9c1xeqg1	126	36	predictive	predictive	JJ
cord-032403-9c1xeqg1	126	37	-	-	JJ
cord-032403-9c1xeqg1	126	38	model	model	NN
cord-032403-9c1xeqg1	126	39	based	base	VBN
cord-032403-9c1xeqg1	126	40	real	real	JJ
cord-032403-9c1xeqg1	126	41	-	-	HYPH
cord-032403-9c1xeqg1	126	42	time	time	NN
cord-032403-9c1xeqg1	126	43	alerts	alert	NNS
cord-032403-9c1xeqg1	126	44	,	,	,
cord-032403-9c1xeqg1	126	45	but	but	CC
cord-032403-9c1xeqg1	126	46	also	also	RB
cord-032403-9c1xeqg1	126	47	automatically	automatically	RB
cord-032403-9c1xeqg1	126	48	take	take	VB
cord-032403-9c1xeqg1	126	49	actions	action	NNS
cord-032403-9c1xeqg1	126	50	based	base	VBN
cord-032403-9c1xeqg1	126	51	on	on	IN
cord-032403-9c1xeqg1	126	52	optimization	optimization	NN
cord-032403-9c1xeqg1	126	53	across	across	IN
cord-032403-9c1xeqg1	126	54	different	different	JJ
cord-032403-9c1xeqg1	126	55	scenarios	scenario	NNS
cord-032403-9c1xeqg1	126	56	.	.	.
cord-032403-9c1xeqg1	127	1	47	47	CD
cord-032403-9c1xeqg1	128	1	While	while	IN
cord-032403-9c1xeqg1	128	2	at	at	IN
cord-032403-9c1xeqg1	128	3	the	the	DT
cord-032403-9c1xeqg1	128	4	process	process	NN
cord-032403-9c1xeqg1	128	5	development	development	NN
cord-032403-9c1xeqg1	128	6	level	level	NN
cord-032403-9c1xeqg1	128	7	,	,	,
cord-032403-9c1xeqg1	128	8	such	such	JJ
cord-032403-9c1xeqg1	128	9	digital	digital	JJ
cord-032403-9c1xeqg1	128	10	twin	twin	NN
cord-032403-9c1xeqg1	128	11	-	-	HYPH
cord-032403-9c1xeqg1	128	12	based	base	VBN
cord-032403-9c1xeqg1	128	13	controls	control	NNS
cord-032403-9c1xeqg1	128	14	could	could	MD
cord-032403-9c1xeqg1	128	15	be	be	VB
cord-032403-9c1xeqg1	128	16	used	use	VBN
cord-032403-9c1xeqg1	128	17	for	for	IN
cord-032403-9c1xeqg1	128	18	efficient	efficient	JJ
cord-032403-9c1xeqg1	128	19	process	process	NN
cord-032403-9c1xeqg1	128	20	design	design	NN
cord-032403-9c1xeqg1	128	21	,	,	,
cord-032403-9c1xeqg1	128	22	at	at	IN
cord-032403-9c1xeqg1	128	23	the	the	DT
cord-032403-9c1xeqg1	128	24	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	128	25	level	level	NN
cord-032403-9c1xeqg1	128	26	,	,	,
cord-032403-9c1xeqg1	128	27	predictive	predictive	JJ
cord-032403-9c1xeqg1	128	28	quality	quality	NN
cord-032403-9c1xeqg1	128	29	and	and	CC
cord-032403-9c1xeqg1	128	30	predictive	predictive	JJ
cord-032403-9c1xeqg1	128	31	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	128	32	are	be	VBP
cord-032403-9c1xeqg1	128	33	likely	likely	JJ
cord-032403-9c1xeqg1	128	34	to	to	TO
cord-032403-9c1xeqg1	128	35	be	be	VB
cord-032403-9c1xeqg1	128	36	the	the	DT
cord-032403-9c1xeqg1	128	37	central	central	JJ
cord-032403-9c1xeqg1	128	38	applications	application	NNS
cord-032403-9c1xeqg1	128	39	.	.	.
cord-032403-9c1xeqg1	129	1	It	-PRON-	PRP
cord-032403-9c1xeqg1	129	2	is	be	VBZ
cord-032403-9c1xeqg1	129	3	important	important	JJ
cord-032403-9c1xeqg1	129	4	to	to	TO
cord-032403-9c1xeqg1	129	5	highlight	highlight	VB
cord-032403-9c1xeqg1	129	6	that	that	IN
cord-032403-9c1xeqg1	129	7	such	such	JJ
cord-032403-9c1xeqg1	129	8	digital	digital	JJ
cord-032403-9c1xeqg1	129	9	twins	twin	NNS
cord-032403-9c1xeqg1	129	10	should	should	MD
cord-032403-9c1xeqg1	129	11	be	be	VB
cord-032403-9c1xeqg1	129	12	realized	realize	VBN
cord-032403-9c1xeqg1	129	13	across	across	IN
cord-032403-9c1xeqg1	129	14	all	all	DT
cord-032403-9c1xeqg1	129	15	interconnected	interconnect	VBN
cord-032403-9c1xeqg1	129	16	unit	unit	NN
cord-032403-9c1xeqg1	129	17	operations	operation	NNS
cord-032403-9c1xeqg1	129	18	,	,	,
cord-032403-9c1xeqg1	129	19	to	to	TO
cord-032403-9c1xeqg1	129	20	enable	enable	VB
cord-032403-9c1xeqg1	129	21	communication	communication	NN
cord-032403-9c1xeqg1	129	22	,	,	,
cord-032403-9c1xeqg1	129	23	scheduling	scheduling	NN
cord-032403-9c1xeqg1	129	24	,	,	,
cord-032403-9c1xeqg1	129	25	and	and	CC
cord-032403-9c1xeqg1	129	26	optimization	optimization	NN
cord-032403-9c1xeqg1	129	27	across	across	IN
cord-032403-9c1xeqg1	129	28	the	the	DT
cord-032403-9c1xeqg1	129	29	entire	entire	JJ
cord-032403-9c1xeqg1	129	30	plant	plant	NN
cord-032403-9c1xeqg1	129	31	.	.	.
cord-032403-9c1xeqg1	130	1	48	48	CD
cord-032403-9c1xeqg1	131	1	Another	another	DT
cord-032403-9c1xeqg1	131	2	very	very	RB
cord-032403-9c1xeqg1	131	3	important	important	JJ
cord-032403-9c1xeqg1	131	4	application	application	NN
cord-032403-9c1xeqg1	131	5	in	in	IN
cord-032403-9c1xeqg1	131	6	bioprocessing	bioprocessing	NN
cord-032403-9c1xeqg1	131	7	is	be	VBZ
cord-032403-9c1xeqg1	131	8	smart	smart	JJ
cord-032403-9c1xeqg1	131	9	operations	operation	NNS
cord-032403-9c1xeqg1	131	10	of	of	IN
cord-032403-9c1xeqg1	131	11	parallel	parallel	JJ
cord-032403-9c1xeqg1	131	12	high	high	JJ
cord-032403-9c1xeqg1	131	13	-	-	HYPH
cord-032403-9c1xeqg1	131	14	throughput	throughput	NN
cord-032403-9c1xeqg1	131	15	experimental	experimental	JJ
cord-032403-9c1xeqg1	131	16	systems	system	NNS
cord-032403-9c1xeqg1	131	17	.	.	.
cord-032403-9c1xeqg1	132	1	Here	here	RB
cord-032403-9c1xeqg1	132	2	such	such	JJ
cord-032403-9c1xeqg1	132	3	digital	digital	JJ
cord-032403-9c1xeqg1	132	4	twins	twin	NNS
cord-032403-9c1xeqg1	132	5	can	can	MD
cord-032403-9c1xeqg1	132	6	efficiently	efficiently	RB
cord-032403-9c1xeqg1	132	7	learn	learn	VB
cord-032403-9c1xeqg1	132	8	across	across	IN
cord-032403-9c1xeqg1	132	9	all	all	DT
cord-032403-9c1xeqg1	132	10	of	of	IN
cord-032403-9c1xeqg1	132	11	the	the	DT
cord-032403-9c1xeqg1	132	12	ongoing	ongoing	JJ
cord-032403-9c1xeqg1	132	13	operations	operation	NNS
cord-032403-9c1xeqg1	132	14	and	and	CC
cord-032403-9c1xeqg1	132	15	reduce	reduce	VB
cord-032403-9c1xeqg1	132	16	(	(	-LRB-
cord-032403-9c1xeqg1	132	17	in	in	IN
cord-032403-9c1xeqg1	132	18	real	real	JJ
cord-032403-9c1xeqg1	132	19	-	-	HYPH
cord-032403-9c1xeqg1	132	20	time	time	NN
cord-032403-9c1xeqg1	132	21	)	)	-RRB-
cord-032403-9c1xeqg1	132	22	the	the	DT
cord-032403-9c1xeqg1	132	23	redundant	redundant	JJ
cord-032403-9c1xeqg1	132	24	information	information	NN
cord-032403-9c1xeqg1	132	25	,	,	,
cord-032403-9c1xeqg1	132	26	while	while	IN
cord-032403-9c1xeqg1	132	27	consistently	consistently	RB
cord-032403-9c1xeqg1	132	28	redesigning	redesign	VBG
cord-032403-9c1xeqg1	132	29	the	the	DT
cord-032403-9c1xeqg1	132	30	experiments	experiment	NNS
cord-032403-9c1xeqg1	132	31	to	to	TO
cord-032403-9c1xeqg1	132	32	provide	provide	VB
cord-032403-9c1xeqg1	132	33	further	further	JJ
cord-032403-9c1xeqg1	132	34	knowledge	knowledge	NN
cord-032403-9c1xeqg1	132	35	.	.	.
cord-032403-9c1xeqg1	133	1	49	49	CD
cord-032403-9c1xeqg1	133	2	,	,	,
cord-032403-9c1xeqg1	133	3	50	50	CD
cord-032403-9c1xeqg1	134	1	In	in	IN
cord-032403-9c1xeqg1	134	2	such	such	JJ
cord-032403-9c1xeqg1	134	3	cases	case	NNS
cord-032403-9c1xeqg1	134	4	,	,	,
cord-032403-9c1xeqg1	134	5	experimental	experimental	JJ
cord-032403-9c1xeqg1	134	6	systems	system	NNS
cord-032403-9c1xeqg1	134	7	and	and	CC
cord-032403-9c1xeqg1	134	8	digital	digital	JJ
cord-032403-9c1xeqg1	134	9	twins	twin	NNS
cord-032403-9c1xeqg1	134	10	must	must	MD
cord-032403-9c1xeqg1	134	11	actively	actively	RB
cord-032403-9c1xeqg1	134	12	collaborate	collaborate	VB
cord-032403-9c1xeqg1	134	13	on	on	IN
cord-032403-9c1xeqg1	134	14	simultaneously	simultaneously	RB
cord-032403-9c1xeqg1	134	15	improving	improve	VBG
cord-032403-9c1xeqg1	134	16	process	process	NN
cord-032403-9c1xeqg1	134	17	understanding	understanding	NN
cord-032403-9c1xeqg1	134	18	as	as	RB
cord-032403-9c1xeqg1	134	19	well	well	RB
cord-032403-9c1xeqg1	134	20	as	as	IN
cord-032403-9c1xeqg1	134	21	the	the	DT
cord-032403-9c1xeqg1	134	22	process	process	NN
cord-032403-9c1xeqg1	134	23	itself	-PRON-	PRP
cord-032403-9c1xeqg1	134	24	.	.	.
cord-032403-9c1xeqg1	135	1	AND	and	CC
cord-032403-9c1xeqg1	135	2	REGULATED	regulate	VBN
cord-032403-9c1xeqg1	135	3	INDUSTRIES	industry	NNS
cord-032403-9c1xeqg1	136	1	If	if	IN
cord-032403-9c1xeqg1	136	2	human	human	JJ
cord-032403-9c1xeqg1	136	3	health	health	NN
cord-032403-9c1xeqg1	136	4	or	or	CC
cord-032403-9c1xeqg1	136	5	even	even	RB
cord-032403-9c1xeqg1	136	6	survival	survival	NN
cord-032403-9c1xeqg1	136	7	is	be	VBZ
cord-032403-9c1xeqg1	136	8	affected	affect	VBN
cord-032403-9c1xeqg1	136	9	by	by	IN
cord-032403-9c1xeqg1	136	10	the	the	DT
cord-032403-9c1xeqg1	136	11	decision	decision	NN
cord-032403-9c1xeqg1	136	12	process	process	NN
cord-032403-9c1xeqg1	136	13	,	,	,
cord-032403-9c1xeqg1	136	14	such	such	JJ
cord-032403-9c1xeqg1	136	15	decisions	decision	NNS
cord-032403-9c1xeqg1	136	16	must	must	MD
cord-032403-9c1xeqg1	136	17	be	be	VB
cord-032403-9c1xeqg1	136	18	accurately	accurately	RB
cord-032403-9c1xeqg1	136	19	documented	document	VBN
cord-032403-9c1xeqg1	136	20	,	,	,
cord-032403-9c1xeqg1	136	21	validated	validate	VBN
cord-032403-9c1xeqg1	136	22	,	,	,
cord-032403-9c1xeqg1	136	23	and	and	CC
cord-032403-9c1xeqg1	136	24	surveilled	surveille	VBN
cord-032403-9c1xeqg1	136	25	.	.	.
cord-032403-9c1xeqg1	137	1	In	in	IN
cord-032403-9c1xeqg1	137	2	biopharmaceutical	biopharmaceutical	JJ
cord-032403-9c1xeqg1	137	3	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	137	4	,	,	,
cord-032403-9c1xeqg1	137	5	health	health	NN
cord-032403-9c1xeqg1	137	6	authorities	authority	NNS
cord-032403-9c1xeqg1	137	7	impose	impose	VBP
cord-032403-9c1xeqg1	137	8	stringent	stringent	JJ
cord-032403-9c1xeqg1	137	9	regulations	regulation	NNS
cord-032403-9c1xeqg1	137	10	on	on	IN
cord-032403-9c1xeqg1	137	11	the	the	DT
cord-032403-9c1xeqg1	137	12	process	process	NN
cord-032403-9c1xeqg1	137	13	design	design	NN
cord-032403-9c1xeqg1	137	14	to	to	TO
cord-032403-9c1xeqg1	137	15	ensure	ensure	VB
cord-032403-9c1xeqg1	137	16	consistent	consistent	JJ
cord-032403-9c1xeqg1	137	17	product	product	NN
cord-032403-9c1xeqg1	137	18	quality	quality	NN
cord-032403-9c1xeqg1	137	19	.	.	.
cord-032403-9c1xeqg1	138	1	Thereby	thereby	RB
cord-032403-9c1xeqg1	138	2	,	,	,
cord-032403-9c1xeqg1	138	3	regulations	regulation	NNS
cord-032403-9c1xeqg1	138	4	such	such	JJ
cord-032403-9c1xeqg1	138	5	as	as	IN
cord-032403-9c1xeqg1	138	6	the	the	DT
cord-032403-9c1xeqg1	138	7	quality	quality	NN
cord-032403-9c1xeqg1	138	8	guidelines	guideline	NNS
cord-032403-9c1xeqg1	138	9	by	by	IN
cord-032403-9c1xeqg1	138	10	the	the	DT
cord-032403-9c1xeqg1	138	11	International	International	NNP
cord-032403-9c1xeqg1	138	12	Council	Council	NNP
cord-032403-9c1xeqg1	138	13	for	for	IN
cord-032403-9c1xeqg1	138	14	Harmonisation	Harmonisation	NNP
cord-032403-9c1xeqg1	138	15	of	of	IN
cord-032403-9c1xeqg1	138	16	Technical	Technical	NNP
cord-032403-9c1xeqg1	138	17	Requirements	Requirements	NNPS
cord-032403-9c1xeqg1	138	18	for	for	IN
cord-032403-9c1xeqg1	138	19	Pharmaceuticals	Pharmaceuticals	NNPS
cord-032403-9c1xeqg1	138	20	for	for	IN
cord-032403-9c1xeqg1	138	21	Human	Human	NNP
cord-032403-9c1xeqg1	138	22	Use	Use	NNP
cord-032403-9c1xeqg1	138	23	51	51	CD
cord-032403-9c1xeqg1	138	24	also	also	RB
cord-032403-9c1xeqg1	138	25	actively	actively	RB
cord-032403-9c1xeqg1	138	26	incentivize	incentivize	VB
cord-032403-9c1xeqg1	138	27	the	the	DT
cord-032403-9c1xeqg1	138	28	utilization	utilization	NN
cord-032403-9c1xeqg1	138	29	of	of	IN
cord-032403-9c1xeqg1	138	30	model	model	NN
cord-032403-9c1xeqg1	138	31	-	-	HYPH
cord-032403-9c1xeqg1	138	32	based	base	VBN
cord-032403-9c1xeqg1	138	33	solutions	solution	NNS
cord-032403-9c1xeqg1	138	34	to	to	TO
cord-032403-9c1xeqg1	138	35	support	support	VB
cord-032403-9c1xeqg1	138	36	understanding	understanding	NN
cord-032403-9c1xeqg1	138	37	and	and	CC
cord-032403-9c1xeqg1	138	38	operation	operation	NN
cord-032403-9c1xeqg1	138	39	of	of	IN
cord-032403-9c1xeqg1	138	40	the	the	DT
cord-032403-9c1xeqg1	138	41	complex	complex	JJ
cord-032403-9c1xeqg1	138	42	processes	process	NNS
cord-032403-9c1xeqg1	138	43	.	.	.
cord-032403-9c1xeqg1	139	1	The	the	DT
cord-032403-9c1xeqg1	139	2	smart	smart	JJ
cord-032403-9c1xeqg1	139	3	digital	digital	JJ
cord-032403-9c1xeqg1	139	4	solution	solution	NN
cord-032403-9c1xeqg1	139	5	-	-	HYPH
cord-032403-9c1xeqg1	139	6	enabled	enable	VBN
cord-032403-9c1xeqg1	139	7	stabilization	stabilization	NN
cord-032403-9c1xeqg1	139	8	of	of	IN
cord-032403-9c1xeqg1	139	9	decisions	decision	NNS
cord-032403-9c1xeqg1	139	10	through	through	IN
cord-032403-9c1xeqg1	139	11	robust	robust	JJ
cord-032403-9c1xeqg1	139	12	learning	learning	NN
cord-032403-9c1xeqg1	139	13	from	from	IN
cord-032403-9c1xeqg1	139	14	previous	previous	JJ
cord-032403-9c1xeqg1	139	15	know	know	NN
cord-032403-9c1xeqg1	139	16	-	-	HYPH
cord-032403-9c1xeqg1	139	17	how	how	NN
cord-032403-9c1xeqg1	139	18	and	and	CC
cord-032403-9c1xeqg1	139	19	data	datum	NNS
cord-032403-9c1xeqg1	139	20	should	should	MD
cord-032403-9c1xeqg1	139	21	be	be	VB
cord-032403-9c1xeqg1	139	22	positively	positively	RB
cord-032403-9c1xeqg1	139	23	embraced	embrace	VBN
cord-032403-9c1xeqg1	139	24	by	by	IN
cord-032403-9c1xeqg1	139	25	drug	drug	NN
cord-032403-9c1xeqg1	139	26	producers	producer	NNS
cord-032403-9c1xeqg1	139	27	as	as	RB
cord-032403-9c1xeqg1	139	28	well	well	RB
cord-032403-9c1xeqg1	139	29	as	as	IN
cord-032403-9c1xeqg1	139	30	health	health	NN
cord-032403-9c1xeqg1	139	31	authorities	authority	NNS
cord-032403-9c1xeqg1	139	32	.	.	.
cord-032403-9c1xeqg1	140	1	However	however	RB
cord-032403-9c1xeqg1	140	2	,	,	,
cord-032403-9c1xeqg1	140	3	in	in	IN
cord-032403-9c1xeqg1	140	4	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	140	5	operations	operation	NNS
cord-032403-9c1xeqg1	140	6	which	which	WDT
cord-032403-9c1xeqg1	140	7	are	be	VBP
cord-032403-9c1xeqg1	140	8	based	base	VBN
cord-032403-9c1xeqg1	140	9	on	on	IN
cord-032403-9c1xeqg1	140	10	Industrial	Industrial	NNP
cord-032403-9c1xeqg1	140	11	&	&	CC
cord-032403-9c1xeqg1	140	12	Engineering	Engineering	NNP
cord-032403-9c1xeqg1	140	13	Chemistry	Chemistry	NNP
cord-032403-9c1xeqg1	141	1	Research	research	NN
cord-032403-9c1xeqg1	141	2	pubs.acs.org/IECR	pubs.acs.org/IECR	NNP
cord-032403-9c1xeqg1	141	3	Commentary	commentary	NN
cord-032403-9c1xeqg1	141	4	decisions	decision	NNS
cord-032403-9c1xeqg1	141	5	either	either	CC
cord-032403-9c1xeqg1	141	6	actively	actively	RB
cord-032403-9c1xeqg1	141	7	introduced	introduce	VBN
cord-032403-9c1xeqg1	141	8	or	or	CC
cord-032403-9c1xeqg1	141	9	supported	support	VBN
cord-032403-9c1xeqg1	141	10	by	by	IN
cord-032403-9c1xeqg1	141	11	such	such	JJ
cord-032403-9c1xeqg1	141	12	models	model	NNS
cord-032403-9c1xeqg1	141	13	,	,	,
cord-032403-9c1xeqg1	141	14	a	a	DT
cord-032403-9c1xeqg1	141	15	detailed	detailed	JJ
cord-032403-9c1xeqg1	141	16	assessment	assessment	NN
cord-032403-9c1xeqg1	141	17	of	of	IN
cord-032403-9c1xeqg1	141	18	these	these	DT
cord-032403-9c1xeqg1	141	19	smart	smart	JJ
cord-032403-9c1xeqg1	141	20	digital	digital	JJ
cord-032403-9c1xeqg1	141	21	solutions	solution	NNS
cord-032403-9c1xeqg1	141	22	is	be	VBZ
cord-032403-9c1xeqg1	141	23	required	require	VBN
cord-032403-9c1xeqg1	141	24	.	.	.
cord-032403-9c1xeqg1	142	1	This	this	DT
cord-032403-9c1xeqg1	142	2	will	will	MD
cord-032403-9c1xeqg1	142	3	inevitably	inevitably	RB
cord-032403-9c1xeqg1	142	4	result	result	VB
cord-032403-9c1xeqg1	142	5	in	in	IN
cord-032403-9c1xeqg1	142	6	a	a	DT
cord-032403-9c1xeqg1	142	7	critical	critical	JJ
cord-032403-9c1xeqg1	142	8	confrontation	confrontation	NN
cord-032403-9c1xeqg1	142	9	of	of	IN
cord-032403-9c1xeqg1	142	10	smart	smart	JJ
cord-032403-9c1xeqg1	142	11	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	142	12	procedures	procedure	NNS
cord-032403-9c1xeqg1	142	13	and	and	CC
cord-032403-9c1xeqg1	142	14	smart	smart	JJ
cord-032403-9c1xeqg1	142	15	humans	human	NNS
cord-032403-9c1xeqg1	142	16	.	.	.
cord-032403-9c1xeqg1	143	1	52	52	CD
cord-032403-9c1xeqg1	144	1	It	-PRON-	PRP
cord-032403-9c1xeqg1	144	2	can	can	MD
cord-032403-9c1xeqg1	144	3	be	be	VB
cord-032403-9c1xeqg1	144	4	expected	expect	VBN
cord-032403-9c1xeqg1	144	5	that	that	IN
cord-032403-9c1xeqg1	144	6	a	a	DT
cord-032403-9c1xeqg1	144	7	growing	grow	VBG
cord-032403-9c1xeqg1	144	8	number	number	NN
cord-032403-9c1xeqg1	144	9	of	of	IN
cord-032403-9c1xeqg1	144	10	companies	company	NNS
cord-032403-9c1xeqg1	144	11	will	will	MD
cord-032403-9c1xeqg1	144	12	increasingly	increasingly	RB
cord-032403-9c1xeqg1	144	13	utilize	utilize	VB
cord-032403-9c1xeqg1	144	14	advanced	advanced	JJ
cord-032403-9c1xeqg1	144	15	predictive	predictive	JJ
cord-032403-9c1xeqg1	144	16	solutions	solution	NNS
cord-032403-9c1xeqg1	144	17	besides	besides	IN
cord-032403-9c1xeqg1	144	18	the	the	DT
cord-032403-9c1xeqg1	144	19	commonly	commonly	RB
cord-032403-9c1xeqg1	144	20	utilized	utilize	VBN
cord-032403-9c1xeqg1	144	21	,	,	,
cord-032403-9c1xeqg1	144	22	static	static	JJ
cord-032403-9c1xeqg1	144	23	multivariate	multivariate	JJ
cord-032403-9c1xeqg1	144	24	techniques	technique	NNS
cord-032403-9c1xeqg1	144	25	,	,	,
cord-032403-9c1xeqg1	144	26	which	which	WDT
cord-032403-9c1xeqg1	144	27	given	give	VBN
cord-032403-9c1xeqg1	144	28	their	-PRON-	PRP$
cord-032403-9c1xeqg1	144	29	linear	linear	JJ
cord-032403-9c1xeqg1	144	30	nature	nature	NN
cord-032403-9c1xeqg1	144	31	are	be	VBP
cord-032403-9c1xeqg1	144	32	much	much	RB
cord-032403-9c1xeqg1	144	33	simpler	simple	JJR
cord-032403-9c1xeqg1	144	34	to	to	TO
cord-032403-9c1xeqg1	144	35	validate	validate	VB
cord-032403-9c1xeqg1	144	36	for	for	IN
cord-032403-9c1xeqg1	144	37	Good	Good	NNP
cord-032403-9c1xeqg1	144	38	Manufacturing	Manufacturing	NNP
cord-032403-9c1xeqg1	144	39	Practice	Practice	NNP
cord-032403-9c1xeqg1	144	40	(	(	-LRB-
cord-032403-9c1xeqg1	144	41	GMP	GMP	NNP
cord-032403-9c1xeqg1	144	42	)	)	-RRB-
cord-032403-9c1xeqg1	144	43	utility	utility	NN
cord-032403-9c1xeqg1	144	44	.	.	.
cord-032403-9c1xeqg1	145	1	This	this	DT
cord-032403-9c1xeqg1	145	2	experience	experience	NN
cord-032403-9c1xeqg1	145	3	will	will	MD
cord-032403-9c1xeqg1	145	4	very	very	RB
cord-032403-9c1xeqg1	145	5	likely	likely	RB
cord-032403-9c1xeqg1	145	6	provide	provide	VB
cord-032403-9c1xeqg1	145	7	more	more	JJR
cord-032403-9c1xeqg1	145	8	clarity	clarity	NN
cord-032403-9c1xeqg1	145	9	on	on	IN
cord-032403-9c1xeqg1	145	10	the	the	DT
cord-032403-9c1xeqg1	145	11	limits	limit	NNS
cord-032403-9c1xeqg1	145	12	of	of	IN
cord-032403-9c1xeqg1	145	13	complexity	complexity	NN
cord-032403-9c1xeqg1	145	14	which	which	WDT
cord-032403-9c1xeqg1	145	15	can	can	MD
cord-032403-9c1xeqg1	145	16	be	be	VB
cord-032403-9c1xeqg1	145	17	introduced	introduce	VBN
cord-032403-9c1xeqg1	145	18	into	into	IN
cord-032403-9c1xeqg1	145	19	such	such	JJ
cord-032403-9c1xeqg1	145	20	smart	smart	JJ
cord-032403-9c1xeqg1	145	21	digital	digital	JJ
cord-032403-9c1xeqg1	145	22	solutions	solution	NNS
cord-032403-9c1xeqg1	145	23	to	to	TO
cord-032403-9c1xeqg1	145	24	ensure	ensure	VB
cord-032403-9c1xeqg1	145	25	transparency	transparency	NN
cord-032403-9c1xeqg1	145	26	and	and	CC
cord-032403-9c1xeqg1	145	27	trackability	trackability	NN
cord-032403-9c1xeqg1	145	28	for	for	IN
cord-032403-9c1xeqg1	145	29	health	health	NN
cord-032403-9c1xeqg1	145	30	authorities	authority	NNS
cord-032403-9c1xeqg1	145	31	,	,	,
cord-032403-9c1xeqg1	145	32	but	but	CC
cord-032403-9c1xeqg1	145	33	also	also	RB
cord-032403-9c1xeqg1	145	34	on	on	IN
cord-032403-9c1xeqg1	145	35	the	the	DT
cord-032403-9c1xeqg1	145	36	general	general	JJ
cord-032403-9c1xeqg1	145	37	filing	filing	NN
cord-032403-9c1xeqg1	145	38	procedure	procedure	NN
cord-032403-9c1xeqg1	145	39	of	of	IN
cord-032403-9c1xeqg1	145	40	a	a	DT
cord-032403-9c1xeqg1	145	41	highly	highly	RB
cord-032403-9c1xeqg1	145	42	interconnected	interconnect	VBN
cord-032403-9c1xeqg1	145	43	,	,	,
cord-032403-9c1xeqg1	145	44	digital	digital	JJ
cord-032403-9c1xeqg1	145	45	-	-	HYPH
cord-032403-9c1xeqg1	145	46	twin	twin	NN
cord-032403-9c1xeqg1	145	47	-	-	HYPH
cord-032403-9c1xeqg1	145	48	supervised	supervise	VBN
cord-032403-9c1xeqg1	145	49	manufacturing	manufacturing	NN
cord-032403-9c1xeqg1	145	50	facility	facility	NN
cord-032403-9c1xeqg1	145	51	.	.	.
cord-032403-9c1xeqg1	146	1	He	-PRON-	PRP
cord-032403-9c1xeqg1	146	2	is	be	VBZ
cord-032403-9c1xeqg1	146	3	cofounder	cofounder	NN
cord-032403-9c1xeqg1	146	4	and	and	CC
cord-032403-9c1xeqg1	146	5	COO	COO	NNP
cord-032403-9c1xeqg1	146	6	of	of	IN
cord-032403-9c1xeqg1	146	7	DataHow	DataHow	NNP
cord-032403-9c1xeqg1	146	8	AG	AG	NNP
cord-032403-9c1xeqg1	146	9	,	,	,
cord-032403-9c1xeqg1	146	10	an	an	DT
cord-032403-9c1xeqg1	146	11	internationally	internationally	RB
cord-032403-9c1xeqg1	146	12	active	active	JJ
cord-032403-9c1xeqg1	146	13	spin	spin	NN
cord-032403-9c1xeqg1	146	14	-	-	HYPH
cord-032403-9c1xeqg1	146	15	off	off	RP
cord-032403-9c1xeqg1	146	16	company	company	NN
cord-032403-9c1xeqg1	146	17	from	from	IN
cord-032403-9c1xeqg1	146	18	ETH	ETH	NNP
cord-032403-9c1xeqg1	146	19	Zurich	Zurich	NNP
cord-032403-9c1xeqg1	146	20	.	.	.
cord-032403-9c1xeqg1	147	1	The	the	DT
cord-032403-9c1xeqg1	147	2	company	company	NN
cord-032403-9c1xeqg1	147	3	specializes	specialize	VBZ
cord-032403-9c1xeqg1	147	4	in	in	IN
cord-032403-9c1xeqg1	147	5	process	process	NN
cord-032403-9c1xeqg1	147	6	digitalization	digitalization	NN
cord-032403-9c1xeqg1	147	7	,	,	,
cord-032403-9c1xeqg1	147	8	data	data	NN
cord-032403-9c1xeqg1	147	9	analytics	analytic	NNS
cord-032403-9c1xeqg1	147	10	,	,	,
cord-032403-9c1xeqg1	147	11	and	and	CC
cord-032403-9c1xeqg1	147	12	modeling	model	VBG
cord-032403-9c1xeqg1	147	13	with	with	IN
cord-032403-9c1xeqg1	147	14	a	a	DT
cord-032403-9c1xeqg1	147	15	particular	particular	JJ
cord-032403-9c1xeqg1	147	16	focus	focus	NN
cord-032403-9c1xeqg1	147	17	on	on	IN
cord-032403-9c1xeqg1	147	18	the	the	DT
cord-032403-9c1xeqg1	147	19	biopharmaceutical	biopharmaceutical	JJ
cord-032403-9c1xeqg1	147	20	domain	domain	NN
cord-032403-9c1xeqg1	147	21	.	.	.
cord-032403-9c1xeqg1	148	1	He	-PRON-	PRP
cord-032403-9c1xeqg1	148	2	also	also	RB
cord-032403-9c1xeqg1	148	3	holds	hold	VBZ
cord-032403-9c1xeqg1	148	4	a	a	DT
cord-032403-9c1xeqg1	148	5	lecturer	lecturer	NN
cord-032403-9c1xeqg1	148	6	position	position	NN
cord-032403-9c1xeqg1	148	7	for	for	IN
cord-032403-9c1xeqg1	148	8	statistics	statistic	NNS
cord-032403-9c1xeqg1	148	9	for	for	IN
cord-032403-9c1xeqg1	148	10	chemical	chemical	JJ
cord-032403-9c1xeqg1	148	11	engineers	engineer	NNS
cord-032403-9c1xeqg1	148	12	at	at	IN
cord-032403-9c1xeqg1	148	13	ETH	ETH	NNP
cord-032403-9c1xeqg1	148	14	and	and	CC
cord-032403-9c1xeqg1	148	15	continues	continue	VBZ
cord-032403-9c1xeqg1	148	16	collaborating	collaborate	VBG
cord-032403-9c1xeqg1	148	17	on	on	IN
cord-032403-9c1xeqg1	148	18	academic	academic	JJ
cord-032403-9c1xeqg1	148	19	projects	project	NNS
cord-032403-9c1xeqg1	148	20	in	in	IN
cord-032403-9c1xeqg1	148	21	his	-PRON-	PRP$
cord-032403-9c1xeqg1	148	22	field	field	NN
cord-032403-9c1xeqg1	148	23	of	of	IN
cord-032403-9c1xeqg1	148	24	expertise	expertise	NN
cord-032403-9c1xeqg1	148	25	.	.	.
cord-032403-9c1xeqg1	149	1	This	this	DT
cord-032403-9c1xeqg1	149	2	invited	invite	VBN
cord-032403-9c1xeqg1	149	3	contribution	contribution	NN
cord-032403-9c1xeqg1	149	4	is	be	VBZ
cord-032403-9c1xeqg1	149	5	part	part	NN
cord-032403-9c1xeqg1	149	6	of	of	IN
cord-032403-9c1xeqg1	149	7	the	the	DT
cord-032403-9c1xeqg1	149	8	I&EC	I&EC	NNP
cord-032403-9c1xeqg1	149	9	Research	Research	NNP
cord-032403-9c1xeqg1	149	10	special	special	JJ
cord-032403-9c1xeqg1	149	11	issue	issue	NN
cord-032403-9c1xeqg1	149	12	for	for	IN
cord-032403-9c1xeqg1	149	13	the	the	DT
cord-032403-9c1xeqg1	149	14	2020	2020	CD
cord-032403-9c1xeqg1	149	15	Class	Class	NNP
cord-032403-9c1xeqg1	149	16	of	of	IN
cord-032403-9c1xeqg1	149	17	Influential	Influential	NNP
cord-032403-9c1xeqg1	149	18	Researchers	Researchers	NNPS
cord-032403-9c1xeqg1	149	19	.	.	.
cord-032403-9c1xeqg1	150	1	The	the	DT
cord-032403-9c1xeqg1	150	2	author	author	NN
cord-032403-9c1xeqg1	150	3	expresses	express	VBZ
cord-032403-9c1xeqg1	150	4	deep	deep	JJ
cord-032403-9c1xeqg1	150	5	gratitude	gratitude	NN
cord-032403-9c1xeqg1	150	6	to	to	IN
cord-032403-9c1xeqg1	150	7	his	-PRON-	PRP$
cord-032403-9c1xeqg1	150	8	colleagues	colleague	NNS
cord-032403-9c1xeqg1	150	9	and	and	CC
cord-032403-9c1xeqg1	150	10	collaborators	collaborator	NNS
cord-032403-9c1xeqg1	150	11	to	to	TO
cord-032403-9c1xeqg1	150	12	jointly	jointly	RB
cord-032403-9c1xeqg1	150	13	develop	develop	VB
cord-032403-9c1xeqg1	150	14	the	the	DT
cord-032403-9c1xeqg1	150	15	vision	vision	NN
cord-032403-9c1xeqg1	150	16	on	on	IN
cord-032403-9c1xeqg1	150	17	the	the	DT
cord-032403-9c1xeqg1	150	18	potential	potential	NN
cord-032403-9c1xeqg1	150	19	of	of	IN
cord-032403-9c1xeqg1	150	20	digitalization	digitalization	NN
cord-032403-9c1xeqg1	150	21	in	in	IN
cord-032403-9c1xeqg1	150	22	bioengineering	bioengineering	NN
cord-032403-9c1xeqg1	150	23	expressed	express	VBN
cord-032403-9c1xeqg1	150	24	in	in	IN
cord-032403-9c1xeqg1	150	25	this	this	DT
cord-032403-9c1xeqg1	150	26	commentary	commentary	NN
cord-032403-9c1xeqg1	150	27	.	.	.
cord-032403-9c1xeqg1	151	1	The	the	DT
cord-032403-9c1xeqg1	151	2	Cost	cost	NN
cord-032403-9c1xeqg1	151	3	of	of	IN
cord-032403-9c1xeqg1	151	4	Staying	stay	VBG
cord-032403-9c1xeqg1	151	5	Open	Open	NNP
cord-032403-9c1xeqg1	151	6	:	:	:
cord-032403-9c1xeqg1	151	7	Voluntary	voluntary	JJ
cord-032403-9c1xeqg1	151	8	Social	social	JJ
cord-032403-9c1xeqg1	151	9	Distancing	Distancing	NNP
cord-032403-9c1xeqg1	151	10	and	and	CC
cord-032403-9c1xeqg1	151	11	Lockdowns	Lockdowns	NNP
cord-032403-9c1xeqg1	151	12	in	in	IN
cord-032403-9c1xeqg1	151	13	the	the	DT
cord-032403-9c1xeqg1	151	14	US	US	NNP
cord-032403-9c1xeqg1	151	15	.	.	.
cord-032403-9c1xeqg1	152	1	SSRN	SSRN	NNP
cord-032403-9c1xeqg1	152	2	Electron	Electron	NNP
cord-032403-9c1xeqg1	153	1	How	how	WRB
cord-032403-9c1xeqg1	153	2	Will	Will	NNP
cord-032403-9c1xeqg1	153	3	Country	country	NN
cord-032403-9c1xeqg1	153	4	-	-	HYPH
cord-032403-9c1xeqg1	153	5	Based	base	VBN
cord-032403-9c1xeqg1	153	6	Mitigation	mitigation	NN
cord-032403-9c1xeqg1	153	7	Measures	measure	NNS
cord-032403-9c1xeqg1	153	8	Influence	influence	NN
cord-032403-9c1xeqg1	154	1	the	the	DT
cord-032403-9c1xeqg1	154	2	Course	course	NN
cord-032403-9c1xeqg1	154	3	of	of	IN
cord-032403-9c1xeqg1	154	4	the	the	DT
cord-032403-9c1xeqg1	154	5	COVID-19	COVID-19	NNP
cord-032403-9c1xeqg1	154	6	Epidemic	Epidemic	NNP
cord-032403-9c1xeqg1	154	7	?	?	.
cord-032403-9c1xeqg1	155	1	(	(	-LRB-
cord-032403-9c1xeqg1	155	2	4	4	LS
cord-032403-9c1xeqg1	155	3	)	)	-RRB-
cord-032403-9c1xeqg1	155	4	WHO	who	WP
cord-032403-9c1xeqg1	155	5	.	.	.
cord-032403-9c1xeqg1	156	1	Coronavirus	Coronavirus	NNP
cord-032403-9c1xeqg1	156	2	Disease	Disease	NNP
cord-032403-9c1xeqg1	157	1	A	a	DT
cord-032403-9c1xeqg1	157	2	Fiasco	Fiasco	NNP
cord-032403-9c1xeqg1	157	3	in	in	IN
cord-032403-9c1xeqg1	157	4	the	the	DT
cord-032403-9c1xeqg1	157	5	Making	making	NN
cord-032403-9c1xeqg1	157	6	?	?	.
cord-032403-9c1xeqg1	158	1	As	as	IN
cord-032403-9c1xeqg1	158	2	the	the	DT
cord-032403-9c1xeqg1	158	3	Coronavirus	Coronavirus	NNP
cord-032403-9c1xeqg1	158	4	Pandemic	Pandemic	NNP
cord-032403-9c1xeqg1	158	5	Takes	take	VBZ
cord-032403-9c1xeqg1	158	6	Hold	hold	NN
cord-032403-9c1xeqg1	158	7	,	,	,
cord-032403-9c1xeqg1	158	8	We	-PRON-	PRP
cord-032403-9c1xeqg1	158	9	Are	be	VBP
cord-032403-9c1xeqg1	158	10	Making	make	VBG
cord-032403-9c1xeqg1	158	11	Decisions	decision	NNS
cord-032403-9c1xeqg1	158	12	without	without	IN
cord-032403-9c1xeqg1	158	13	Reliable	Reliable	NNP
cord-032403-9c1xeqg1	158	14	Data	Data	NNP
cord-032403-9c1xeqg1	158	15	.	.	.
cord-032403-9c1xeqg1	159	1	GV	GV	NNP
cord-032403-9c1xeqg1	159	2	Wire	Wire	NNP
cord-032403-9c1xeqg1	159	3	Fed	Fed	NNP
cord-032403-9c1xeqg1	159	4	-	-	HYPH
cord-032403-9c1xeqg1	159	5	Batch	Batch	NNP
cord-032403-9c1xeqg1	159	6	and	and	CC
cord-032403-9c1xeqg1	159	7	Perfusion	Perfusion	NNP
cord-032403-9c1xeqg1	159	8	Culture	culture	NN
cord-032403-9c1xeqg1	159	9	Processes	process	NNS
cord-032403-9c1xeqg1	159	10	:	:	:
cord-032403-9c1xeqg1	159	11	Economic	economic	JJ
cord-032403-9c1xeqg1	159	12	,	,	,
cord-032403-9c1xeqg1	159	13	Environmental	Environmental	NNP
cord-032403-9c1xeqg1	159	14	,	,	,
cord-032403-9c1xeqg1	159	15	and	and	CC
cord-032403-9c1xeqg1	159	16	Operational	Operational	NNP
cord-032403-9c1xeqg1	159	17	Feasibility	Feasibility	NNP
cord-032403-9c1xeqg1	159	18	under	under	IN
cord-032403-9c1xeqg1	159	19	Uncertainty	Uncertainty	NNP
cord-032403-9c1xeqg1	159	20	The	the	DT
cord-032403-9c1xeqg1	159	21	Market	Market	NNP
cord-032403-9c1xeqg1	159	22	of	of	IN
cord-032403-9c1xeqg1	159	23	Biopharmaceutical	Biopharmaceutical	NNP
cord-032403-9c1xeqg1	159	24	Medicines	Medicines	NNPS
cord-032403-9c1xeqg1	159	25	:	:	:
cord-032403-9c1xeqg1	159	26	A	a	DT
cord-032403-9c1xeqg1	159	27	Snapshot	snapshot	NN
cord-032403-9c1xeqg1	159	28	of	of	IN
cord-032403-9c1xeqg1	159	29	a	a	DT
cord-032403-9c1xeqg1	159	30	Diverse	diverse	JJ
cord-032403-9c1xeqg1	159	31	Industrial	Industrial	NNP
cord-032403-9c1xeqg1	159	32	Landscape	landscape	NN
cord-032403-9c1xeqg1	159	33	Biopharmaceutical	Biopharmaceutical	NNP
cord-032403-9c1xeqg1	159	34	Benchmarks	Benchmarks	NNP
cord-032403-9c1xeqg1	159	35	Evolving	evolve	VBG
cord-032403-9c1xeqg1	159	36	Trends	trend	NNS
cord-032403-9c1xeqg1	159	37	in	in	IN
cord-032403-9c1xeqg1	159	38	MAb	MAb	NNP
cord-032403-9c1xeqg1	159	39	Production	production	NN
cord-032403-9c1xeqg1	159	40	Processes	Processes	NNPS
cord-032403-9c1xeqg1	159	41	Production	Production	NNP
cord-032403-9c1xeqg1	159	42	of	of	IN
cord-032403-9c1xeqg1	159	43	Protein	Protein	NNP
cord-032403-9c1xeqg1	159	44	Therapeutics	Therapeutics	NNP
cord-032403-9c1xeqg1	159	45	in	in	IN
cord-032403-9c1xeqg1	159	46	the	the	DT
cord-032403-9c1xeqg1	159	47	Quality	quality	NN
cord-032403-9c1xeqg1	159	48	by	by	IN
cord-032403-9c1xeqg1	159	49	Design	Design	NNP
cord-032403-9c1xeqg1	159	50	(	(	-LRB-
cord-032403-9c1xeqg1	159	51	QbD	qbd	NN
cord-032403-9c1xeqg1	159	52	)	)	-RRB-
cord-032403-9c1xeqg1	159	53	Paradigm	Paradigm	NNP
cord-032403-9c1xeqg1	159	54	.	.	.
cord-032403-9c1xeqg1	160	1	Top	top	JJ
cord-032403-9c1xeqg1	160	2	Engineering	Engineering	NNP
cord-032403-9c1xeqg1	160	3	Challenges	challenge	NNS
cord-032403-9c1xeqg1	160	4	in	in	IN
cord-032403-9c1xeqg1	160	5	Therapeutic	Therapeutic	NNP
cord-032403-9c1xeqg1	160	6	Protein	Protein	NNP
cord-032403-9c1xeqg1	160	7	Product	Product	NNP
cord-032403-9c1xeqg1	160	8	and	and	CC
cord-032403-9c1xeqg1	160	9	Process	Process	NNP
cord-032403-9c1xeqg1	160	10	Design	Design	NNP
cord-032403-9c1xeqg1	160	11	Big	Big	NNP
cord-032403-9c1xeqg1	160	12	Data	Data	NNP
cord-032403-9c1xeqg1	160	13	in	in	IN
cord-032403-9c1xeqg1	160	14	Biopharmaceutical	Biopharmaceutical	NNP
cord-032403-9c1xeqg1	160	15	Process	Process	NNP
cord-032403-9c1xeqg1	160	16	Development	Development	NNP
cord-032403-9c1xeqg1	160	17	:	:	:
cord-032403-9c1xeqg1	160	18	Vice	Vice	NNP
cord-032403-9c1xeqg1	160	19	or	or	CC
cord-032403-9c1xeqg1	160	20	Virtue	Virtue	NNP
cord-032403-9c1xeqg1	160	21	?	?	.
cord-032403-9c1xeqg1	161	1	Workflow	workflow	NN
cord-032403-9c1xeqg1	161	2	for	for	IN
cord-032403-9c1xeqg1	161	3	Criticality	Criticality	NNP
cord-032403-9c1xeqg1	161	4	Assessment	Assessment	NNP
cord-032403-9c1xeqg1	161	5	Applied	Applied	NNP
cord-032403-9c1xeqg1	161	6	in	in	IN
cord-032403-9c1xeqg1	161	7	Biopharmaceutical	Biopharmaceutical	NNP
cord-032403-9c1xeqg1	161	8	Process	Process	NNP
cord-032403-9c1xeqg1	161	9	Validation	Validation	NNP
cord-032403-9c1xeqg1	161	10	Stage	stage	NN
cord-032403-9c1xeqg1	161	11	1	1	CD
cord-032403-9c1xeqg1	162	1	Covid-19	Covid-19	NNP
cord-032403-9c1xeqg1	162	2	-Navigating	-navigate	VBG
cord-032403-9c1xeqg1	162	3	the	the	DT
cord-032403-9c1xeqg1	162	4	Uncharted	Uncharted	NNP
cord-032403-9c1xeqg1	162	5	COVID-19	COVID-19	NNP
cord-032403-9c1xeqg1	162	6	in	in	IN
cord-032403-9c1xeqg1	162	7	Italy	Italy	NNP
cord-032403-9c1xeqg1	162	8	:	:	:
cord-032403-9c1xeqg1	163	1	Momentous	momentous	JJ
cord-032403-9c1xeqg1	163	2	Decisions	Decisions	NNPS
cord-032403-9c1xeqg1	163	3	and	and	CC
cord-032403-9c1xeqg1	163	4	Many	many	JJ
cord-032403-9c1xeqg1	163	5	Uncertainties	uncertainty	NNS
cord-032403-9c1xeqg1	163	6	.	.	.
cord-032403-9c1xeqg1	164	1	The	the	DT
cord-032403-9c1xeqg1	164	2	Lancet	Lancet	NNP
cord-032403-9c1xeqg1	164	3	Global	Global	NNP
cord-032403-9c1xeqg1	164	4	Health	Health	NNP
cord-032403-9c1xeqg1	165	1	The	the	DT
cord-032403-9c1xeqg1	165	2	Scientific	Scientific	NNP
cord-032403-9c1xeqg1	165	3	Literature	Literature	NNP
cord-032403-9c1xeqg1	165	4	on	on	IN
cord-032403-9c1xeqg1	165	5	Coronaviruses	Coronaviruses	NNP
cord-032403-9c1xeqg1	165	6	,	,	,
cord-032403-9c1xeqg1	165	7	COVID-19	COVID-19	NNP
cord-032403-9c1xeqg1	165	8	and	and	CC
cord-032403-9c1xeqg1	165	9	Its	Its	NNP
cord-032403-9c1xeqg1	165	10	Associated	Associated	NNP
cord-032403-9c1xeqg1	165	11	Safety	Safety	NNP
cord-032403-9c1xeqg1	165	12	-	-	HYPH
cord-032403-9c1xeqg1	165	13	Related	Related	NNP
cord-032403-9c1xeqg1	165	14	Research	Research	NNP
cord-032403-9c1xeqg1	165	15	Dimensions	dimension	NNS
cord-032403-9c1xeqg1	165	16	:	:	:
cord-032403-9c1xeqg1	166	1	A	a	DT
cord-032403-9c1xeqg1	166	2	Scientometric	Scientometric	NNP
cord-032403-9c1xeqg1	166	3	Analysis	Analysis	NNP
cord-032403-9c1xeqg1	166	4	and	and	CC
cord-032403-9c1xeqg1	166	5	Scoping	Scoping	NNP
cord-032403-9c1xeqg1	166	6	Review	Review	NNP
cord-032403-9c1xeqg1	167	1	Hybrid	Hybrid	NNP
cord-032403-9c1xeqg1	167	2	Semi	Semi	NNP
cord-032403-9c1xeqg1	167	3	-	-	JJ
cord-032403-9c1xeqg1	167	4	Parametric	parametric	JJ
cord-032403-9c1xeqg1	167	5	Modeling	Modeling	NNP
cord-032403-9c1xeqg1	167	6	in	in	IN
cord-032403-9c1xeqg1	167	7	Process	Process	NNP
cord-032403-9c1xeqg1	167	8	Systems	Systems	NNPS
cord-032403-9c1xeqg1	167	9	Engineering	Engineering	NNP
cord-032403-9c1xeqg1	167	10	:	:	:
cord-032403-9c1xeqg1	168	1	Past	past	NN
cord-032403-9c1xeqg1	168	2	,	,	,
cord-032403-9c1xeqg1	168	3	Present	Present	NNP
cord-032403-9c1xeqg1	168	4	and	and	CC
cord-032403-9c1xeqg1	168	5	Future	Future	NNP
cord-032403-9c1xeqg1	168	6	A	a	DT
cord-032403-9c1xeqg1	168	7	New	new	JJ
cord-032403-9c1xeqg1	168	8	Generation	generation	NN
cord-032403-9c1xeqg1	168	9	of	of	IN
cord-032403-9c1xeqg1	168	10	Predictive	Predictive	NNP
cord-032403-9c1xeqg1	168	11	Models	Models	NNPS
cord-032403-9c1xeqg1	168	12	:	:	:
cord-032403-9c1xeqg1	169	1	The	the	DT
cord-032403-9c1xeqg1	169	2	Added	Added	NNP
cord-032403-9c1xeqg1	169	3	Value	Value	NNP
cord-032403-9c1xeqg1	169	4	of	of	IN
cord-032403-9c1xeqg1	169	5	Hybrid	Hybrid	NNP
cord-032403-9c1xeqg1	169	6	Models	Models	NNPS
cord-032403-9c1xeqg1	169	7	for	for	IN
cord-032403-9c1xeqg1	169	8	Manufacturing	Manufacturing	NNP
cord-032403-9c1xeqg1	169	9	Processes	process	NNS
cord-032403-9c1xeqg1	169	10	of	of	IN
cord-032403-9c1xeqg1	169	11	Therapeutic	therapeutic	JJ
cord-032403-9c1xeqg1	169	12	Proteins	Proteins	NNP
cord-032403-9c1xeqg1	169	13	Model	Model	NNP
cord-032403-9c1xeqg1	169	14	-	-	HYPH
cord-032403-9c1xeqg1	169	15	Based	base	VBN
cord-032403-9c1xeqg1	169	16	Methods	Methods	NNPS
cord-032403-9c1xeqg1	169	17	in	in	IN
cord-032403-9c1xeqg1	169	18	the	the	DT
cord-032403-9c1xeqg1	169	19	Biopharmaceutical	Biopharmaceutical	NNP
cord-032403-9c1xeqg1	169	20	Process	Process	NNP
cord-032403-9c1xeqg1	169	21	Lifecycle	Lifecycle	NNP
cord-032403-9c1xeqg1	169	22	Identification	Identification	NNP
cord-032403-9c1xeqg1	169	23	of	of	IN
cord-032403-9c1xeqg1	169	24	Manipulated	manipulate	VBN
cord-032403-9c1xeqg1	169	25	Variables	variable	NNS
cord-032403-9c1xeqg1	169	26	for	for	IN
cord-032403-9c1xeqg1	169	27	a	a	DT
cord-032403-9c1xeqg1	169	28	Glycosylation	Glycosylation	NNP
cord-032403-9c1xeqg1	169	29	Control	Control	NNP
cord-032403-9c1xeqg1	169	30	Strategy	Strategy	NNP
cord-032403-9c1xeqg1	169	31	Application	Application	NNP
cord-032403-9c1xeqg1	169	32	of	of	IN
cord-032403-9c1xeqg1	169	33	Quality	Quality	NNP
cord-032403-9c1xeqg1	169	34	by	by	IN
cord-032403-9c1xeqg1	169	35	Design	Design	NNP
cord-032403-9c1xeqg1	169	36	to	to	IN
cord-032403-9c1xeqg1	169	37	the	the	DT
cord-032403-9c1xeqg1	169	38	Characterization	characterization	NN
cord-032403-9c1xeqg1	169	39	of	of	IN
cord-032403-9c1xeqg1	169	40	the	the	DT
cord-032403-9c1xeqg1	169	41	Cell	Cell	NNP
cord-032403-9c1xeqg1	169	42	Culture	Culture	NNP
cord-032403-9c1xeqg1	169	43	Process	Process	NNP
cord-032403-9c1xeqg1	169	44	of	of	IN
cord-032403-9c1xeqg1	169	45	an	an	DT
cord-032403-9c1xeqg1	169	46	Fc	Fc	NNP
cord-032403-9c1xeqg1	169	47	-	-	HYPH
cord-032403-9c1xeqg1	169	48	Fusion	Fusion	NNP
cord-032403-9c1xeqg1	169	49	Protein	Protein	NNP
cord-032403-9c1xeqg1	169	50	Industrial	Industrial	NNP
cord-032403-9c1xeqg1	169	51	&	&	CC
cord-032403-9c1xeqg1	169	52	Engineering	Engineering	NNP
cord-032403-9c1xeqg1	169	53	Chemistry	Chemistry	NNP
cord-032403-9c1xeqg1	169	54	Research	Research	NNP
cord-032403-9c1xeqg1	169	55	pubs.acs.org/IECR	pubs.acs.org/IECR	NNP
cord-032403-9c1xeqg1	170	1	Commentary	Commentary	NNP
cord-032403-9c1xeqg1	170	2	Enhanced	Enhanced	NNP
cord-032403-9c1xeqg1	170	3	Process	Process	NNP
cord-032403-9c1xeqg1	170	4	Understanding	Understanding	NNP
cord-032403-9c1xeqg1	170	5	and	and	CC
cord-032403-9c1xeqg1	170	6	Multivariate	Multivariate	NNP
cord-032403-9c1xeqg1	170	7	Prediction	Prediction	NNP
cord-032403-9c1xeqg1	170	8	of	of	IN
cord-032403-9c1xeqg1	170	9	the	the	DT
cord-032403-9c1xeqg1	170	10	Relationship	relationship	NN
cord-032403-9c1xeqg1	170	11	between	between	IN
cord-032403-9c1xeqg1	170	12	Cell	Cell	NNP
cord-032403-9c1xeqg1	170	13	Culture	Culture	NNP
cord-032403-9c1xeqg1	170	14	Process	Process	NNP
cord-032403-9c1xeqg1	170	15	and	and	CC
cord-032403-9c1xeqg1	170	16	Monoclonal	Monoclonal	NNP
cord-032403-9c1xeqg1	170	17	Antibody	Antibody	NNP
cord-032403-9c1xeqg1	170	18	Quality	Quality	NNP
cord-032403-9c1xeqg1	170	19	Insights	Insights	NNP
cord-032403-9c1xeqg1	170	20	into	into	IN
cord-032403-9c1xeqg1	170	21	the	the	DT
cord-032403-9c1xeqg1	170	22	Dynamics	Dynamics	NNPS
cord-032403-9c1xeqg1	170	23	and	and	CC
cord-032403-9c1xeqg1	170	24	Control	Control	NNP
cord-032403-9c1xeqg1	170	25	of	of	IN
cord-032403-9c1xeqg1	170	26	COVID-19	COVID-19	NNP
cord-032403-9c1xeqg1	170	27	Infection	Infection	NNP
cord-032403-9c1xeqg1	170	28	Rates	Rates	NNPS
cord-032403-9c1xeqg1	170	29	Early	Early	NNP
cord-032403-9c1xeqg1	170	30	Dynamics	Dynamics	NNPS
cord-032403-9c1xeqg1	170	31	of	of	IN
cord-032403-9c1xeqg1	170	32	Transmission	Transmission	NNP
cord-032403-9c1xeqg1	170	33	and	and	CC
cord-032403-9c1xeqg1	170	34	Control	Control	NNP
cord-032403-9c1xeqg1	170	35	of	of	IN
cord-032403-9c1xeqg1	170	36	COVID-19	COVID-19	NNP
cord-032403-9c1xeqg1	170	37	:	:	:
cord-032403-9c1xeqg1	170	38	A	a	DT
cord-032403-9c1xeqg1	170	39	Mathematical	Mathematical	NNP
cord-032403-9c1xeqg1	170	40	Modelling	Modelling	NNP
cord-032403-9c1xeqg1	170	41	Study	Study	NNP
cord-032403-9c1xeqg1	170	42	Hybrid	Hybrid	NNP
cord-032403-9c1xeqg1	170	43	Modeling	Modeling	NNP
cord-032403-9c1xeqg1	170	44	for	for	IN
cord-032403-9c1xeqg1	170	45	Quality	quality	NN
cord-032403-9c1xeqg1	170	46	by	by	IN
cord-032403-9c1xeqg1	170	47	Design	Design	NNP
cord-032403-9c1xeqg1	170	48	and	and	CC
cord-032403-9c1xeqg1	170	49	PAT	PAT	NNP
cord-032403-9c1xeqg1	170	50	-	-	HYPH
cord-032403-9c1xeqg1	170	51	Benefits	benefit	NNS
cord-032403-9c1xeqg1	170	52	and	and	CC
cord-032403-9c1xeqg1	170	53	Challenges	challenge	NNS
cord-032403-9c1xeqg1	170	54	of	of	IN
cord-032403-9c1xeqg1	170	55	Applications	Applications	NNPS
cord-032403-9c1xeqg1	170	56	in	in	IN
cord-032403-9c1xeqg1	170	57	Biopharmaceutical	Biopharmaceutical	NNP
cord-032403-9c1xeqg1	170	58	Industry	Industry	NNP
cord-032403-9c1xeqg1	170	59	Hybrid	Hybrid	NNP
cord-032403-9c1xeqg1	170	60	Modeling	Modeling	NNP
cord-032403-9c1xeqg1	170	61	as	as	IN
cord-032403-9c1xeqg1	170	62	a	a	DT
cord-032403-9c1xeqg1	170	63	QbD	qbd	NN
cord-032403-9c1xeqg1	170	64	/	/	SYM
cord-032403-9c1xeqg1	170	65	PAT	PAT	NNP
cord-032403-9c1xeqg1	170	66	Tool	Tool	NNP
cord-032403-9c1xeqg1	170	67	in	in	IN
cord-032403-9c1xeqg1	170	68	Process	Process	NNP
cord-032403-9c1xeqg1	170	69	Development	Development	NNP
cord-032403-9c1xeqg1	170	70	:	:	:
cord-032403-9c1xeqg1	171	1	An	an	DT
cord-032403-9c1xeqg1	171	2	Industrial	Industrial	NNP
cord-032403-9c1xeqg1	171	3	E.	E.	NNP
cord-032403-9c1xeqg1	171	4	Coli	Coli	NNP
cord-032403-9c1xeqg1	171	5	Case	Case	NNP
cord-032403-9c1xeqg1	171	6	Study	Study	NNP
cord-032403-9c1xeqg1	171	7	Hybrid	Hybrid	NNP
cord-032403-9c1xeqg1	171	8	-	-	HYPH
cord-032403-9c1xeqg1	171	9	EKF	ekf	NN
cord-032403-9c1xeqg1	171	10	:	:	:
cord-032403-9c1xeqg1	171	11	Hybrid	Hybrid	NNP
cord-032403-9c1xeqg1	171	12	Model	Model	NNP
cord-032403-9c1xeqg1	171	13	Coupled	couple	VBN
cord-032403-9c1xeqg1	171	14	with	with	IN
cord-032403-9c1xeqg1	171	15	Extended	Extended	NNP
cord-032403-9c1xeqg1	171	16	Kalman	Kalman	NNP
cord-032403-9c1xeqg1	171	17	Filter	Filter	NNP
cord-032403-9c1xeqg1	171	18	for	for	IN
cord-032403-9c1xeqg1	171	19	Real	real	JJ
cord-032403-9c1xeqg1	171	20	-	-	HYPH
cord-032403-9c1xeqg1	171	21	time	time	NN
cord-032403-9c1xeqg1	171	22	Monitoring	Monitoring	NNP
cord-032403-9c1xeqg1	171	23	and	and	CC
cord-032403-9c1xeqg1	171	24	Control	Control	NNP
cord-032403-9c1xeqg1	171	25	of	of	IN
cord-032403-9c1xeqg1	171	26	Mammalian	Mammalian	NNP
cord-032403-9c1xeqg1	171	27	Cell	Cell	NNP
cord-032403-9c1xeqg1	171	28	Culture	Culture	NNP
cord-032403-9c1xeqg1	171	29	Quality	quality	NN
cord-032403-9c1xeqg1	171	30	by	by	IN
cord-032403-9c1xeqg1	171	31	Control	control	NN
cord-032403-9c1xeqg1	171	32	:	:	:
cord-032403-9c1xeqg1	172	1	Towards	towards	IN
cord-032403-9c1xeqg1	172	2	Model	Model	NNP
cord-032403-9c1xeqg1	172	3	Predictive	Predictive	NNP
cord-032403-9c1xeqg1	172	4	Control	Control	NNP
cord-032403-9c1xeqg1	172	5	of	of	IN
cord-032403-9c1xeqg1	172	6	Mammalian	mammalian	JJ
cord-032403-9c1xeqg1	172	7	Cell	cell	NN
cord-032403-9c1xeqg1	172	8	Culture	culture	NN
cord-032403-9c1xeqg1	172	9	Bioprocesses	bioprocesse	NNS
cord-032403-9c1xeqg1	173	1	A	a	DT
cord-032403-9c1xeqg1	173	2	General	General	NNP
cord-032403-9c1xeqg1	173	3	Hybrid	Hybrid	NNP
cord-032403-9c1xeqg1	173	4	Semi	Semi	NNP
cord-032403-9c1xeqg1	173	5	-	-	NNP
cord-032403-9c1xeqg1	173	6	Parametric	Parametric	NNP
cord-032403-9c1xeqg1	173	7	Process	Process	NNP
cord-032403-9c1xeqg1	173	8	Control	Control	NNP
cord-032403-9c1xeqg1	173	9	Framework	Framework	NNP
cord-032403-9c1xeqg1	173	10	Hybrid	Hybrid	NNP
cord-032403-9c1xeqg1	173	11	Metabolic	Metabolic	NNP
cord-032403-9c1xeqg1	173	12	Flux	Flux	NNP
cord-032403-9c1xeqg1	173	13	Analysis	Analysis	NNP
cord-032403-9c1xeqg1	173	14	/	/	SYM
cord-032403-9c1xeqg1	173	15	Data	Data	NNP
cord-032403-9c1xeqg1	173	16	-	-	HYPH
cord-032403-9c1xeqg1	173	17	Driven	Driven	NNP
cord-032403-9c1xeqg1	173	18	Modelling	Modelling	NNP
cord-032403-9c1xeqg1	173	19	of	of	IN
cord-032403-9c1xeqg1	173	20	Bioprocesses	Bioprocesses	NNP
cord-032403-9c1xeqg1	173	21	Systematic	Systematic	NNP
cord-032403-9c1xeqg1	173	22	Interpolation	Interpolation	NNP
cord-032403-9c1xeqg1	173	23	Method	Method	NNP
cord-032403-9c1xeqg1	173	24	Predicts	predict	VBZ
cord-032403-9c1xeqg1	173	25	Protein	Protein	NNP
cord-032403-9c1xeqg1	173	26	Chromatographic	Chromatographic	NNP
cord-032403-9c1xeqg1	173	27	Elution	Elution	NNP
cord-032403-9c1xeqg1	173	28	from	from	IN
cord-032403-9c1xeqg1	173	29	Batch	Batch	NNP
cord-032403-9c1xeqg1	173	30	Isotherm	Isotherm	NNP
cord-032403-9c1xeqg1	173	31	Data	Data	NNP
cord-032403-9c1xeqg1	173	32	without	without	IN
cord-032403-9c1xeqg1	173	33	a	a	DT
cord-032403-9c1xeqg1	173	34	Detailed	Detailed	NNP
cord-032403-9c1xeqg1	173	35	Mechanistic	Mechanistic	NNP
cord-032403-9c1xeqg1	173	36	Isotherm	Isotherm	NNP
cord-032403-9c1xeqg1	173	37	Model	Model	NNP
cord-032403-9c1xeqg1	173	38	Insights	Insights	NNPS
cord-032403-9c1xeqg1	173	39	on	on	IN
cord-032403-9c1xeqg1	173	40	Transfer	Transfer	NNP
cord-032403-9c1xeqg1	173	41	Optimization	Optimization	NNP
cord-032403-9c1xeqg1	173	42	:	:	:
cord-032403-9c1xeqg1	174	1	Because	because	IN
cord-032403-9c1xeqg1	174	2	Experience	experience	NN
cord-032403-9c1xeqg1	174	3	Is	be	VBZ
cord-032403-9c1xeqg1	174	4	the	the	DT
cord-032403-9c1xeqg1	174	5	Best	good	JJS
cord-032403-9c1xeqg1	174	6	Teacher	teacher	NN
cord-032403-9c1xeqg1	174	7	Deep	Deep	NNP
cord-032403-9c1xeqg1	174	8	Convolutional	Convolutional	NNP
cord-032403-9c1xeqg1	174	9	Neural	Neural	NNP
cord-032403-9c1xeqg1	174	10	Networks	Networks	NNP
cord-032403-9c1xeqg1	174	11	for	for	IN
cord-032403-9c1xeqg1	174	12	Computer	computer	NN
cord-032403-9c1xeqg1	174	13	-	-	HYPH
cord-032403-9c1xeqg1	174	14	Aided	aid	VBN
cord-032403-9c1xeqg1	174	15	Detection	detection	NN
cord-032403-9c1xeqg1	174	16	:	:	:
cord-032403-9c1xeqg1	174	17	CNN	CNN	NNP
cord-032403-9c1xeqg1	174	18	Architectures	Architectures	NNPS
cord-032403-9c1xeqg1	174	19	,	,	,
cord-032403-9c1xeqg1	174	20	Dataset	Dataset	NNP
cord-032403-9c1xeqg1	174	21	Characteristics	Characteristics	NNPS
cord-032403-9c1xeqg1	174	22	and	and	CC
cord-032403-9c1xeqg1	174	23	Transfer	Transfer	NNP
cord-032403-9c1xeqg1	174	24	Learning	Learning	NNP
cord-032403-9c1xeqg1	174	25	Role	role	NN
cord-032403-9c1xeqg1	174	26	of	of	IN
cord-032403-9c1xeqg1	174	27	Knowledge	Knowledge	NNP
cord-032403-9c1xeqg1	174	28	Management	Management	NNP
cord-032403-9c1xeqg1	174	29	in	in	IN
cord-032403-9c1xeqg1	174	30	Development	Development	NNP
cord-032403-9c1xeqg1	174	31	and	and	CC
cord-032403-9c1xeqg1	174	32	Lifecycle	Lifecycle	NNP
cord-032403-9c1xeqg1	174	33	Management	Management	NNP
cord-032403-9c1xeqg1	174	34	of	of	IN
cord-032403-9c1xeqg1	174	35	Biopharmaceuticals	Biopharmaceuticals	NNP
cord-032403-9c1xeqg1	174	36	Machine	Machine	NNP
cord-032403-9c1xeqg1	174	37	Learning	Learning	NNP
cord-032403-9c1xeqg1	174	38	:	:	:
cord-032403-9c1xeqg1	174	39	Overview	overview	NN
cord-032403-9c1xeqg1	174	40	of	of	IN
cord-032403-9c1xeqg1	174	41	the	the	DT
cord-032403-9c1xeqg1	174	42	Recent	Recent	NNP
cord-032403-9c1xeqg1	174	43	Progresses	Progresses	NNPS
cord-032403-9c1xeqg1	174	44	and	and	CC
cord-032403-9c1xeqg1	174	45	Implications	implication	NNS
cord-032403-9c1xeqg1	174	46	for	for	IN
cord-032403-9c1xeqg1	174	47	the	the	DT
cord-032403-9c1xeqg1	174	48	Process	Process	NNP
cord-032403-9c1xeqg1	174	49	Systems	Systems	NNPS
cord-032403-9c1xeqg1	174	50	Engineering	Engineering	NNP
cord-032403-9c1xeqg1	174	51	Field	Field	NNP
cord-032403-9c1xeqg1	174	52	Provable	Provable	NNP
cord-032403-9c1xeqg1	174	53	Data	Data	NNP
cord-032403-9c1xeqg1	174	54	Integrity	integrity	NN
cord-032403-9c1xeqg1	174	55	in	in	IN
cord-032403-9c1xeqg1	174	56	the	the	DT
cord-032403-9c1xeqg1	174	57	Pharmaceutical	Pharmaceutical	NNP
cord-032403-9c1xeqg1	174	58	Industry	Industry	NNP
cord-032403-9c1xeqg1	174	59	Based	Based	NNP
cord-032403-9c1xeqg1	174	60	on	on	IN
cord-032403-9c1xeqg1	174	61	Version	Version	NNP
cord-032403-9c1xeqg1	174	62	Control	Control	NNP
cord-032403-9c1xeqg1	174	63	Systems	Systems	NNPS
cord-032403-9c1xeqg1	174	64	and	and	CC
cord-032403-9c1xeqg1	174	65	the	the	DT
cord-032403-9c1xeqg1	174	66	Blockchain	Blockchain	NNP
cord-032403-9c1xeqg1	174	67	Organizational	Organizational	NNP
cord-032403-9c1xeqg1	174	68	Transformation	Transformation	NNP
cord-032403-9c1xeqg1	174	69	for	for	IN
cord-032403-9c1xeqg1	174	70	Sustainable	Sustainable	NNP
cord-032403-9c1xeqg1	174	71	Development	Development	NNP
cord-032403-9c1xeqg1	174	72	:	:	:
cord-032403-9c1xeqg1	174	73	A	a	DT
cord-032403-9c1xeqg1	174	74	Case	Case	NNP
cord-032403-9c1xeqg1	174	75	Study	Study	NNP
cord-032403-9c1xeqg1	174	76	,	,	,
cord-032403-9c1xeqg1	174	77	Management	Management	NNP
cord-032403-9c1xeqg1	174	78	of	of	IN
cord-032403-9c1xeqg1	174	79	Permanent	Permanent	NNP
cord-032403-9c1xeqg1	174	80	Change	Change	NNP
cord-032403-9c1xeqg1	174	81	Digital	Digital	NNP
cord-032403-9c1xeqg1	174	82	Finance	Finance	NNP
cord-032403-9c1xeqg1	174	83	and	and	CC
cord-032403-9c1xeqg1	174	84	FinTech	FinTech	NNP
cord-032403-9c1xeqg1	174	85	:	:	:
cord-032403-9c1xeqg1	174	86	Current	Current	NNP
cord-032403-9c1xeqg1	174	87	Research	Research	NNP
cord-032403-9c1xeqg1	174	88	and	and	CC
cord-032403-9c1xeqg1	174	89	Future	Future	NNP
cord-032403-9c1xeqg1	174	90	Research	Research	NNP
cord-032403-9c1xeqg1	174	91	Directions	Directions	NNP
cord-032403-9c1xeqg1	174	92	Cross	Cross	NNP
cord-032403-9c1xeqg1	174	93	-	-	HYPH
cord-032403-9c1xeqg1	174	94	Scale	Scale	NNP
cord-032403-9c1xeqg1	174	95	Predictive	Predictive	NNP
cord-032403-9c1xeqg1	174	96	Modeling	Modeling	NNP
cord-032403-9c1xeqg1	174	97	of	of	IN
cord-032403-9c1xeqg1	174	98	CHO	CHO	NNP
cord-032403-9c1xeqg1	174	99	Cell	Cell	NNP
cord-032403-9c1xeqg1	174	100	Culture	Culture	NNP
cord-032403-9c1xeqg1	174	101	Growth	growth	NN
cord-032403-9c1xeqg1	174	102	and	and	CC
cord-032403-9c1xeqg1	174	103	Metabolites	metabolite	NNS
cord-032403-9c1xeqg1	174	104	Using	use	VBG
cord-032403-9c1xeqg1	174	105	Raman	Raman	NNP
cord-032403-9c1xeqg1	174	106	Spectroscopy	Spectroscopy	NNP
cord-032403-9c1xeqg1	174	107	and	and	CC
cord-032403-9c1xeqg1	174	108	Multivariate	Multivariate	NNP
cord-032403-9c1xeqg1	174	109	Analysis	Analysis	NNP
cord-032403-9c1xeqg1	174	110	Line	Line	NNP
cord-032403-9c1xeqg1	174	111	and	and	CC
cord-032403-9c1xeqg1	174	112	Real	Real	NNP
cord-032403-9c1xeqg1	174	113	-	-	HYPH
cord-032403-9c1xeqg1	174	114	Time	Time	NNP
cord-032403-9c1xeqg1	174	115	Prediction	Prediction	NNP
cord-032403-9c1xeqg1	174	116	of	of	IN
cord-032403-9c1xeqg1	174	117	Recombinant	Recombinant	NNP
cord-032403-9c1xeqg1	174	118	Antibody	Antibody	NNP
cord-032403-9c1xeqg1	174	119	Titer	Titer	NNP
cord-032403-9c1xeqg1	174	120	by	by	IN
cord-032403-9c1xeqg1	174	121	in	in	IN
cord-032403-9c1xeqg1	174	122	Situ	Situ	NNP
cord-032403-9c1xeqg1	174	123	Raman	Raman	NNP
cord-032403-9c1xeqg1	174	124	Spectroscopy	Spectroscopy	NNP
cord-032403-9c1xeqg1	174	125	Sequential	Sequential	NNP
cord-032403-9c1xeqg1	174	126	Multivariate	multivariate	JJ
cord-032403-9c1xeqg1	174	127	Cell	cell	NN
cord-032403-9c1xeqg1	174	128	Culture	culture	NN
cord-032403-9c1xeqg1	174	129	Modeling	modeling	NN
cord-032403-9c1xeqg1	174	130	at	at	IN
cord-032403-9c1xeqg1	174	131	Multiple	multiple	JJ
cord-032403-9c1xeqg1	174	132	Scales	Scales	NNPS
cord-032403-9c1xeqg1	174	133	Supports	support	VBZ
cord-032403-9c1xeqg1	174	134	Systematic	systematic	JJ
cord-032403-9c1xeqg1	174	135	Shaping	shaping	NN
cord-032403-9c1xeqg1	174	136	of	of	IN
cord-032403-9c1xeqg1	174	137	a	a	DT
cord-032403-9c1xeqg1	174	138	Monoclonal	Monoclonal	NNP
cord-032403-9c1xeqg1	174	139	Antibody	Antibody	NNP
cord-032403-9c1xeqg1	174	140	Toward	toward	IN
cord-032403-9c1xeqg1	174	141	a	a	DT
cord-032403-9c1xeqg1	174	142	Quality	Quality	NNP
cord-032403-9c1xeqg1	174	143	Target	Target	NNP
cord-032403-9c1xeqg1	174	144	A	a	DT
cord-032403-9c1xeqg1	174	145	Machine	machine	NN
cord-032403-9c1xeqg1	174	146	-	-	HYPH
cord-032403-9c1xeqg1	174	147	Learning	learning	NN
cord-032403-9c1xeqg1	174	148	Approach	Approach	NNP
cord-032403-9c1xeqg1	174	149	to	to	TO
cord-032403-9c1xeqg1	174	150	Calibrate	calibrate	VB
cord-032403-9c1xeqg1	174	151	Generic	generic	JJ
cord-032403-9c1xeqg1	174	152	Raman	Raman	NNP
cord-032403-9c1xeqg1	174	153	Models	model	NNS
cord-032403-9c1xeqg1	174	154	for	for	IN
cord-032403-9c1xeqg1	174	155	Real	Real	NNP
cord-032403-9c1xeqg1	174	156	-	-	HYPH
cord-032403-9c1xeqg1	174	157	Time	time	NN
cord-032403-9c1xeqg1	174	158	Monitoring	Monitoring	NNP
cord-032403-9c1xeqg1	174	159	of	of	IN
cord-032403-9c1xeqg1	174	160	Cell	cell	NN
cord-032403-9c1xeqg1	174	161	Culture	culture	NN
cord-032403-9c1xeqg1	174	162	Processes	process	NNS
cord-032403-9c1xeqg1	175	1	Accelerating	accelerate	VBG
cord-032403-9c1xeqg1	175	2	Biologics	Biologics	NNP
cord-032403-9c1xeqg1	175	3	Manufacturing	Manufacturing	NNP
cord-032403-9c1xeqg1	175	4	by	by	IN
cord-032403-9c1xeqg1	175	5	Modeling	Modeling	NNP
cord-032403-9c1xeqg1	175	6	or	or	CC
cord-032403-9c1xeqg1	176	1	:	:	:
cord-032403-9c1xeqg1	176	2	Is	be	VBZ
cord-032403-9c1xeqg1	176	3	Approval	approval	NN
cord-032403-9c1xeqg1	176	4	under	under	IN
cord-032403-9c1xeqg1	176	5	the	the	DT
cord-032403-9c1xeqg1	176	6	QbD	qbd	NN
cord-032403-9c1xeqg1	176	7	and	and	CC
cord-032403-9c1xeqg1	176	8	PAT	PAT	NNP
cord-032403-9c1xeqg1	176	9	Approaches	approach	NNS
cord-032403-9c1xeqg1	177	1	Demanded	demand	VBN
cord-032403-9c1xeqg1	177	2	by	by	IN
cord-032403-9c1xeqg1	177	3	Authorities	authority	NNS
cord-032403-9c1xeqg1	177	4	Acceptable	acceptable	JJ
cord-032403-9c1xeqg1	177	5	without	without	IN
cord-032403-9c1xeqg1	177	6	a	a	DT
cord-032403-9c1xeqg1	177	7	Digital	Digital	NNP
cord-032403-9c1xeqg1	177	8	-	-	HYPH
cord-032403-9c1xeqg1	177	9	Twin	Twin	NNP
cord-032403-9c1xeqg1	177	10	?	?	.
cord-032403-9c1xeqg1	178	1	Processes	Processes	NNP
cord-032403-9c1xeqg1	178	2	Processwide	Processwide	NNP
cord-032403-9c1xeqg1	178	3	Control	Control	NNP
cord-032403-9c1xeqg1	178	4	and	and	CC
cord-032403-9c1xeqg1	178	5	Automation	Automation	NNP
cord-032403-9c1xeqg1	178	6	of	of	IN
cord-032403-9c1xeqg1	178	7	an	an	DT
cord-032403-9c1xeqg1	178	8	Integrated	Integrated	NNP
cord-032403-9c1xeqg1	178	9	Continuous	Continuous	NNP
cord-032403-9c1xeqg1	178	10	Manufacturing	Manufacturing	NNP
cord-032403-9c1xeqg1	178	11	Platform	Platform	NNP
cord-032403-9c1xeqg1	178	12	for	for	IN
cord-032403-9c1xeqg1	178	13	Antibodies	Antibodies	NNP
cord-032403-9c1xeqg1	178	14	Integrated	Integrated	NNP
cord-032403-9c1xeqg1	178	15	Optimization	Optimization	NNP
cord-032403-9c1xeqg1	178	16	of	of	IN
cord-032403-9c1xeqg1	178	17	Upstream	Upstream	NNP
cord-032403-9c1xeqg1	178	18	and	and	CC
cord-032403-9c1xeqg1	178	19	Downstream	Downstream	NNP
cord-032403-9c1xeqg1	178	20	Processing	processing	NN
cord-032403-9c1xeqg1	178	21	in	in	IN
cord-032403-9c1xeqg1	178	22	Biopharmaceutical	Biopharmaceutical	NNP
cord-032403-9c1xeqg1	178	23	Manufacturing	Manufacturing	NNP
cord-032403-9c1xeqg1	178	24	under	under	IN
cord-032403-9c1xeqg1	178	25	Uncertainty	uncertainty	NN
cord-032403-9c1xeqg1	178	26	:	:	:
cord-032403-9c1xeqg1	179	1	A	a	DT
cord-032403-9c1xeqg1	179	2	Chance	chance	NN
cord-032403-9c1xeqg1	180	1	Constrained	Constrained	NNP
cord-032403-9c1xeqg1	180	2	Programming	Programming	NNP
cord-032403-9c1xeqg1	180	3	Approach	Approach	NNP
cord-032403-9c1xeqg1	180	4	Online	Online	NNP
cord-032403-9c1xeqg1	180	5	Optimal	Optimal	NNP
cord-032403-9c1xeqg1	181	1	Experimental	experimental	JJ
cord-032403-9c1xeqg1	181	2	Re	Re	NNP
cord-032403-9c1xeqg1	181	3	-	-	NN
cord-032403-9c1xeqg1	181	4	Design	design	NN
cord-032403-9c1xeqg1	182	1	in	in	IN
cord-032403-9c1xeqg1	182	2	Robotic	Robotic	NNP
cord-032403-9c1xeqg1	182	3	Parallel	Parallel	NNP
cord-032403-9c1xeqg1	182	4	Fed	Fed	NNP
cord-032403-9c1xeqg1	182	5	-	-	HYPH
cord-032403-9c1xeqg1	182	6	Batch	Batch	NNP
cord-032403-9c1xeqg1	182	7	Cultivation	Cultivation	NNP
cord-032403-9c1xeqg1	182	8	Facilities	Facilities	NNPS
cord-032403-9c1xeqg1	182	9	Monitoring	Monitoring	NNP
cord-032403-9c1xeqg1	182	10	Parallel	Parallel	NNP
cord-032403-9c1xeqg1	182	11	Robotic	Robotic	NNP
cord-032403-9c1xeqg1	182	12	Cultivations	Cultivations	NNPS
cord-032403-9c1xeqg1	182	13	with	with	IN
cord-032403-9c1xeqg1	182	14	Online	Online	NNP
cord-032403-9c1xeqg1	182	15	Multivariate	Multivariate	NNP
cord-032403-9c1xeqg1	182	16	Analysis	Analysis	NNP
cord-032403-9c1xeqg1	182	17	Commentary	commentary	NN
cord-032403-9c1xeqg1	182	18	:	:	:
cord-032403-9c1xeqg1	182	19	The	the	DT
cord-032403-9c1xeqg1	182	20	Smart	Smart	NNP
cord-032403-9c1xeqg1	182	21	Human	Human	NNP
cord-032403-9c1xeqg1	182	22	in	in	IN
cord-032403-9c1xeqg1	182	23	Smart	Smart	NNP
cord-032403-9c1xeqg1	182	24	Manufacturing	Manufacturing	NNP