id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009772-pzxvicee	GRÜNBERG, K.	Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo	2006-04-27		.txt	text/plain	4953	350	58	title: Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo Conclusion We conclude that the severity of cold, as induced by experimental RV16 infection, is a determinant of the increase in airway hypersensitivity to histamine in patients with asthma. Since none of these studies was placebo-controlled, it seems mandatory to examine the effect of experimental rhinovirus infection on airway sensitivity to histamine in asthmatic subjects by using such a design. In the present study, we hypothesized that experimental RVI6 colds in atopic asthmatic patients increase airway sensitivity to histamine. During the course of the study, there were no significant effects on baseline FEV| within either the placebo group or in the RVl 6-treated subjects with a mild or severe cold (MANOVA, P -0.99) ( Figure 1 ). Two previous studies on experimental rhinovirus infection in asthma [!3.14| showed small and variable changes in airway hypersensitivity.	./cache/cord-009772-pzxvicee.txt	./txt/cord-009772-pzxvicee.txt