id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257654-8u9m1k5q	Tschöpe, Carsten	Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis	2020-07-14		.txt	text/plain	6281	370	43	On the basis of the link between inflammation, fibrosis, aldosterone, and extracellular matrix regulation, we aimed to investigate the effect of an early intervention with the mineralocorticoid receptor antagonist (MRA) eplerenone on cardiac remodelling in a murine model of persistent coxsackievirus B3 (CVB3)‐induced myocarditis. 40 Because an uncontrolled early fulminant activated immune reaction together with aldosterone can trigger an irreversible cardiac damage with long-time consequences for cardiac remodelling and function in the post-inflammatory myocarditis phase, we sought to demonstrate whether an early intervention with the mineralocorticoid receptor antagonist (MRA) eplerenone (EPL) exerts cardio-beneficial effects to balance the inflammatory defence and healing reaction of the immune system in a murine model of persisting CVB3-induced myocarditis. However, no significant changes in nitrotyrosine staining were detected in any group at 28 days p.i. In vitro, EPL decreased the oxidative stress, depicted as DCF+ cells, in CVB3-infected HL-1 cardiomyocytes ( Figure 5E) .	./cache/cord-257654-8u9m1k5q.txt	./txt/cord-257654-8u9m1k5q.txt