id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309588-kw4d32dt	Chan, Michael H.M.	Steroid-induced osteonecrosis in severe acute respiratory syndrome: a retrospective analysis of biochemical markers of bone metabolism and corticosteroid therapy	2006-06-30		.txt	text/plain	4614	245	46	Summary Aim We investigated the effect of massive doses of corticosteroid therapy on bone metabolism using specific biochemical markers of bone metabolism, and the prevalence of osteonecrosis in severe acute respiratory syndrome (SARS) patients at a university teaching hospital in Hong Kong. Biochemical markers of bone metabolism were analysed retrospectively using serial clotted blood samples collected from each patient during the course of hospital admission to discharge and subsequent follow-up at out-patient clinic using the arbitrary time periods: (i) Day <10; (ii) Day 28-44; (iii) Day 51-84; and (iv) Day >90 after the onset of fever. Aim: We investigated the effect of massive doses of corticosteroid therapy on bone metabolism using specific biochemical markers of bone metabolism, and the prevalence of osteonecrosis in severe acute respiratory syndrome (SARS) patients at a university teaching hospital in Hong Kong. 9, 10 In this study, biochemical markers of bone metabolism were used retrospectively to investigate the effect of massive doses of pulse and maintenance corticosteroid therapies on patients with SARS.	./cache/cord-309588-kw4d32dt.txt	./txt/cord-309588-kw4d32dt.txt