id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310249-cvv77f10	Yule, Terecita D.	Canine parvovirus vaccine elicits protection from the inflammatory and clinical consequences of the disease	1997-05-31		.txt	text/plain	4606	247	45	In canine parvovirus infected puppies we measured the levels of acute phase proteins and changes in leukocyte phenotypes and cell trafficking by flow cytometry. In this study we evaluated whether measuring levels of acute phase proteins and investigating changes in leukocyte phenotypes by flow cytometry would complement conventional clinical assessment of a vaccine efficacy study. The association of these parameters with the major clinical signs of parvovirus induced disease in vaccinated vs nonvaccinated animals is described for seropositive puppies given a CPV-2 vaccine followed by experimental infection with CPV-2b. Low but significant SAA values were observed in three vaccinates on sporadic days post-challenge, but these values did not coincide with clinical signs, virus shed or hematologic changes. Using cell specific antibodies and flow cytometric analysis, a mean of 88% of leukocytes in peripheral Days Post CPV-2 Challenge blood were positively identified as T-cells (CD4+ and CD@, pan-T), B-cells, monocytes, and neutrophils when compared to the absolute leukocyte count obtained conventionally.	./cache/cord-310249-cvv77f10.txt	./txt/cord-310249-cvv77f10.txt