id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343789-6tq0kcfd	Al-Tawfiq, Jaffar A.	Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study	2014-01-06		.txt	text/plain	2625	153	59	title: Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study RESULTS: All patients were critically ill with acute respiratory distress syndrome treated with adjunctive corticosteroids and were on mechanical ventilation at the time of initiation of therapy. Since the discovery of Middle East respiratory syndrome coronavirus (MERS-CoV), the virus has caused 163 cases of disease, with a fatality rate of 43-50%. In a recent review, based on therapies used for the related severe acute respiratory syndrome (SARS) coronavirus, the possible use of interferon and ribavirin was considered as a therapeutic option. 8 The purpose of this study was to describe the outcome of the use of a combination of interferon-a2b and ribavirin in the management of five patients with MERS-CoV infections. 20 In a rhesus macaque model of MERS-CoV infection, the combination of interferon-a2b and ribavirin therapy was effective in limiting the disease and resulted in very mild radiographic evidence of pneumonia.	./cache/cord-343789-6tq0kcfd.txt	./txt/cord-343789-6tq0kcfd.txt