Carrel name: keyword-day-cord Creating study carrel named keyword-day-cord Initializing database file: cache/cord-000705-w52dc97h.json key: cord-000705-w52dc97h authors: Ríos, Fernando G; Estenssoro, Elisa; Villarejo, Fernando; Valentini, Ricardo; Aguilar, Liliana; Pezzola, Daniel; Valdez, Pascual; Blasco, Miguel; Orlandi, Cristina; Alvarez, Javier; Saldarini, Fernando; Gómez, Alejandro; Gómez, Pablo E; Deheza, Martin; Zazu, Alan; Quinteros, Mónica; Chena, Ariel; Osatnik, Javier; Violi, Damian; Gonzalez, Maria Eugenia; Chiappero, Guillermo title: Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic date: 2011-08-17 journal: Crit Care DOI: 10.1186/cc10369 sha: doc_id: 705 cord_uid: w52dc97h file: cache/cord-000059-5hwqdnx1.json key: cord-000059-5hwqdnx1 authors: Tokars, Jerome I.; Burkom, Howard; Xing, Jian; English, Roseanne; Bloom, Steven; Cox, Kenneth; Pavlin, Julie A. title: Enhancing Time-Series Detection Algorithms for Automated Biosurveillance date: 2009-04-17 journal: Emerg Infect Dis DOI: 10.3201/1504.080616 sha: doc_id: 59 cord_uid: 5hwqdnx1 file: cache/cord-002957-gw2cow0d.json key: cord-002957-gw2cow0d authors: Gray, Darren W.; Welsh, Michael D.; Mansoor, Fawad; Doherty, Simon; Chevallier, Olivier P.; Elliott, Christopher T.; Mooney, Mark H. title: DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles date: 2018-04-05 journal: PLoS One DOI: 10.1371/journal.pone.0194488 sha: doc_id: 2957 cord_uid: gw2cow0d file: cache/cord-001192-zbogocki.json key: cord-001192-zbogocki authors: van Meer, Maurits PA; Bastiaens, Guido JH; Boulaksil, Mohamed; de Mast, Quirijn; Gunasekera, Anusha; Hoffman, Stephen L; Pop, Gheorghe; van der Ven, André JAM; Sauerwein, Robert W title: Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report date: 2014-01-30 journal: Malar J DOI: 10.1186/1475-2875-13-38 sha: doc_id: 1192 cord_uid: zbogocki file: cache/cord-002659-566uoozj.json key: cord-002659-566uoozj authors: Fujimoto, Yousuke; Hasegawa, Shunji; Matsushige, Takeshi; Wakiguchi, Hiroyuki; Nakamura, Tamaki; Hasegawa, Hideki; Nakajima, Noriko; Ainai, Akira; Oga, Atsunori; Itoh, Hiroshi; Shirabe, Komei; Toda, Shoichi; Atsuta, Ryo; Morishima, Tsuneo; Ohga, Shouichi title: Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection date: 2017-08-22 journal: Sci Rep DOI: 10.1038/s41598-017-08030-w sha: doc_id: 2659 cord_uid: 566uoozj file: cache/cord-003533-8m0vyxq8.json key: cord-003533-8m0vyxq8 authors: Jayathilaka, P. G. N. S.; Mendis, A. S. V.; Perera, M. H. M. T. S.; Damsiri, H. M. T.; Gunaratne, A. V. C.; Agampodi, Suneth Buddhika title: An outbreak of leptospirosis with predominant cardiac involvement: a case series date: 2019-03-18 journal: BMC Infect Dis DOI: 10.1186/s12879-019-3905-7 sha: doc_id: 3533 cord_uid: 8m0vyxq8 file: cache/cord-000097-vueo83vk.json key: cord-000097-vueo83vk authors: Beretta, Chiara; Leoni, Veronica; Rossi, Mario Renato; Jankovic, Momcilo; Patroniti, Nicolo; Foti, Giuseppe; Biagi, Ettore title: Prolonged extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome in a child affected by rituximab-resistant autoimmune hemolytic anemia: a case report date: 2009-04-01 journal: J Med Case Reports DOI: 10.1186/1752-1947-3-6443 sha: doc_id: 97 cord_uid: vueo83vk file: cache/cord-007178-h0ordzm9.json key: cord-007178-h0ordzm9 authors: Felts, Paul A.; Woolston, Anne-Marie; Fernando, Himali B.; Asquith, Stephen; Gregson, Norman A.; Mizzi, Oliver J.; Smith, Kenneth J. title: Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide date: 2005-05-04 journal: Brain DOI: 10.1093/brain/awh516 sha: doc_id: 7178 cord_uid: h0ordzm9 file: cache/cord-015389-vwgai4k9.json key: cord-015389-vwgai4k9 authors: nan title: Publication only date: 2009-03-25 journal: Bone Marrow Transplant DOI: 10.1038/bmt.2009.50 sha: doc_id: 15389 cord_uid: vwgai4k9 file: cache/cord-001262-8s7g2wvd.json key: cord-001262-8s7g2wvd authors: Zheng, Guoping; Huang, Lanfang; Tong, Haijiang; Shu, Qiang; Hu, Yaoqin; Ge, Menghua; Deng, Keqin; Zhang, Liuya; Zou, Bin; Cheng, Baoli; Xu, Jianguo title: Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study date: 2014-04-04 journal: Respir Res DOI: 10.1186/1465-9921-15-39 sha: doc_id: 1262 cord_uid: 8s7g2wvd file: cache/cord-006876-v2m5l5wz.json key: cord-006876-v2m5l5wz authors: nan title: Neurocritical Care Society 14(th) Annual Meeting date: 2016-08-11 journal: Neurocrit Care DOI: 10.1007/s12028-016-0301-7 sha: doc_id: 6876 cord_uid: v2m5l5wz file: cache/cord-007288-lzxi6q1p.json key: cord-007288-lzxi6q1p authors: Pazin, George J.; Harger, James H.; Armstrong, John A.; Breinig, Mary K.; Caplan, Richard J.; Cantell, Karl; Ho, Monto title: Leukocyte Interferon for Treating First Episodes of Genital Herpes in Women date: 1987-12-17 journal: J Infect Dis DOI: 10.1093/infdis/156.6.891 sha: doc_id: 7288 cord_uid: lzxi6q1p file: cache/cord-002945-29nj4f05.json key: cord-002945-29nj4f05 authors: Ambrose, Rebecca K.; Gravel, Jennifer L.; Commins, Margaret A.; Fowler, Elizabeth V.; Mahony, Timothy J. title: In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c) date: 2018-01-19 journal: Pathogens DOI: 10.3390/pathogens7010012 sha: doc_id: 2945 cord_uid: 29nj4f05 file: cache/cord-010130-28bt3x25.json key: cord-010130-28bt3x25 authors: Crocchiolo, R.; Bramanti, S.; Vai, A.; Sarina, B.; Mineri, R.; Casari, E.; Tordato, F.; Mauro, E.; Timofeeva, I.; Lugli, E.; Mavilio, D.; Carlo‐Stella, C.; Santoro, A.; Castagna, L. title: Infections after T‐replete haploidentical transplantation and high‐dose cyclophosphamide as graft‐versus‐host disease prophylaxis date: 2015-03-26 journal: Transpl Infect Dis DOI: 10.1111/tid.12365 sha: doc_id: 10130 cord_uid: 28bt3x25 file: cache/cord-018239-n7axd9bq.json key: cord-018239-n7axd9bq authors: Rusoke-Dierich, Olaf title: Travel Medicine date: 2018-03-13 journal: Diving Medicine DOI: 10.1007/978-3-319-73836-9_32 sha: doc_id: 18239 cord_uid: n7axd9bq file: cache/cord-163587-zjnr7vwm.json key: cord-163587-zjnr7vwm authors: Altmejd, Adam; Rocklov, Joacim; Wallin, Jonas title: Nowcasting Covid-19 statistics reported withdelay: a case-study of Sweden date: 2020-06-11 journal: nan DOI: nan sha: doc_id: 163587 cord_uid: zjnr7vwm file: cache/cord-032240-xswtx940.json key: cord-032240-xswtx940 authors: Sauer, François; Dagrenat, Charlotte; Couppie, Philippe; Jochum, Gaelle; Leddet, Pierre title: Pericardial effusion in patients with COVID-19: case series date: 2020-09-09 journal: Eur Heart J Case Rep DOI: 10.1093/ehjcr/ytaa287 sha: doc_id: 32240 cord_uid: xswtx940 file: cache/cord-034257-kl2ccmz5.json key: cord-034257-kl2ccmz5 authors: de Jonge, Jeroen C.; Woodhouse, Lisa J.; Reinink, Hendrik; van der Worp, H. Bart; Bath, Philip M. title: PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment date: 2020-10-26 journal: Trials DOI: 10.1186/s13063-020-04717-0 sha: doc_id: 34257 cord_uid: kl2ccmz5 file: cache/cord-224211-6lsvjfqb.json key: cord-224211-6lsvjfqb authors: Schaback, Robert title: Modelling Recovered Cases and Death Probabilities for the COVID-19 Outbreak date: 2020-03-26 journal: nan DOI: nan sha: doc_id: 224211 cord_uid: 6lsvjfqb file: cache/cord-021453-vf8xbaug.json key: cord-021453-vf8xbaug authors: Dysko, Robert C.; Nemzek, Jean A.; Levin, Stephen I.; DeMarco, George J.; Moalli, Maria R. title: Biology and Diseases of Dogs date: 2007-09-02 journal: Laboratory Animal Medicine DOI: 10.1016/b978-012263951-7/50014-4 sha: doc_id: 21453 cord_uid: vf8xbaug file: cache/cord-029112-u507i0t0.json key: cord-029112-u507i0t0 authors: Smith, Keisha; Pace, Amy; Ortiz, Stephan; Kazani, Shamsah; Rottinghaus, Scott title: A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date: 2020-07-13 journal: Trials DOI: 10.1186/s13063-020-04548-z sha: doc_id: 29112 cord_uid: u507i0t0 file: cache/cord-030957-45tc5ksf.json key: cord-030957-45tc5ksf authors: Schaap, Andrew; Weeks, Kathi; Maiguascha, Bice; Barvosa, Edwina; Bassel, Leah; Apostolidis, Paul title: The politics of precarity date: 2020-08-28 journal: Contemp Polit Theory DOI: 10.1057/s41296-020-00435-z sha: doc_id: 30957 cord_uid: 45tc5ksf file: cache/cord-027259-f4sgobcz.json key: cord-027259-f4sgobcz authors: Metsker, Oleg; Igor, Vozniuk; Kopanitsa, Georgy; Morozova, Elena; Maria, Prohorova title: Stroke ICU Patient Mortality Day Prediction date: 2020-05-23 journal: Computational Science - ICCS 2020 DOI: 10.1007/978-3-030-50423-6_29 sha: doc_id: 27259 cord_uid: f4sgobcz file: cache/cord-027811-vk3qnumx.json key: cord-027811-vk3qnumx authors: Freedberg, Daniel E.; Messina, Megan; Lynch, Elissa; Tess, Monika; Miracle, Elizabeth; Chong, David H.; Wahab, Romina; Abrams, Julian A.; Wang, Harris H.; Munck, Christian title: Impact of Fiber-Based Enteral Nutrition on the Gut Microbiome of ICU Patients Receiving Broad-Spectrum Antibiotics: A Randomized Pilot Trial date: 2020-06-11 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000135 sha: doc_id: 27811 cord_uid: vk3qnumx file: cache/cord-009772-pzxvicee.json key: cord-009772-pzxvicee authors: GRÜNBERG, K.; TIMMERS, M. C.; SMITS, H. H.; de KLERK, E. P. A.; DICK, E. C.; SPAAN, W. J. M.; HIEMSTRA, P. S.; STERK, P. J. title: Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo date: 2006-04-27 journal: Clin Exp Allergy DOI: 10.1111/j.1365-2222.1997.tb00670.x sha: doc_id: 9772 cord_uid: pzxvicee file: cache/cord-271298-7vk3wgw1.json key: cord-271298-7vk3wgw1 authors: Sato, Tomoi; Meguid, Michael M; Quinn, Robert H; Zhang, Lihua; Chen, Chung title: Feeding behavior during sialodacryoadenitis viral infection in rats date: 2001-04-30 journal: Physiol Behav DOI: 10.1016/s0031-9384(01)00420-6 sha: doc_id: 271298 cord_uid: 7vk3wgw1 file: cache/cord-266183-uzuda3ir.json key: cord-266183-uzuda3ir authors: Renieris, Georgios; Katrini, Konstantina; Damoulari, Christina; Akinosoglou, Karolina; Psarrakis, Christos; Kyriakopoulou, Magdalini; Dimopoulos, George; Lada, Malvina; Koufargyris, Panagiotis; Giamarellos-Bourboulis, Evangelos J. title: Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Corona virus date: 2020-05-18 journal: Shock DOI: 10.1097/shk.0000000000001562 sha: doc_id: 266183 cord_uid: uzuda3ir file: cache/cord-256015-tt58n0jk.json key: cord-256015-tt58n0jk authors: Zhu, Juanjuan; Zhou, Wei; Zhou, Mingyu; Liu, Yang; Yang, Jing; Li, Haiyang; Zhao, Xueke title: Clinical characteristics and therapeutic procedure for a critical case of novel coronavirus pneumonia treated with glucocorticoids and non-invasive ventilator treatment date: 2020-06-01 journal: Revista da Sociedade Brasileira de Medicina Tropical DOI: 10.1590/0037-8682-0227-2020 sha: doc_id: 256015 cord_uid: tt58n0jk file: cache/cord-005777-6rvfsx4p.json key: cord-005777-6rvfsx4p authors: nan title: PS 0420-0716 date: 2007-08-25 journal: Intensive Care Med DOI: 10.1007/s00134-007-0823-8 sha: doc_id: 5777 cord_uid: 6rvfsx4p file: cache/cord-006391-esnsa4u5.json key: cord-006391-esnsa4u5 authors: nan title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 journal: Langenbecks Arch Chir DOI: 10.1007/bf01279099 sha: doc_id: 6391 cord_uid: esnsa4u5 file: cache/cord-033791-q0wizf2n.json key: cord-033791-q0wizf2n authors: Kavirayani, Akhila; Charlesworth, James E G; Segal, Shelley; Kelly, Dominic; Wilson, Shaun; Qureshi, Amrana; Blanco, Esther; Weitz, James; O'Shea, Deirdre; Bailey, Kathryn title: The Lazarus effect of very high-dose intravenous anakinra in severe non-familial CNS-HLH date: 2020-10-15 journal: Lancet Rheumatol DOI: 10.1016/s2665-9913(20)30361-1 sha: doc_id: 33791 cord_uid: q0wizf2n file: cache/cord-257654-8u9m1k5q.json key: cord-257654-8u9m1k5q authors: Tschöpe, Carsten; Van Linthout, Sophie; Jäger, Sebastian; Arndt, Robert; Trippel, Tobias; Müller, Irene; Elsanhoury, Ahmed; Rutschow, Susanne; Anker, Stefan D.; Schultheiss, Heinz‐Peter; Pauschinger, Matthias; Spillmann, Frank; Pappritz, Kathleen title: Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis date: 2020-07-14 journal: ESC Heart Fail DOI: 10.1002/ehf2.12887 sha: doc_id: 257654 cord_uid: 8u9m1k5q file: cache/cord-266571-qbskh1uu.json key: cord-266571-qbskh1uu authors: de Arriba, M.L; Carvajal, A; Pozo, J; Rubio, P title: Lymphoproliferative responses and protection in conventional piglets inoculated orally with virulent or attenuated porcine epidemic diarrhoea virus date: 2002-06-04 journal: J Virol Methods DOI: 10.1016/s0166-0934(02)00063-0 sha: doc_id: 266571 cord_uid: qbskh1uu file: cache/cord-268341-103xf3dw.json key: cord-268341-103xf3dw authors: Parra, Beatriz; Hinton, David R.; Lin, Mark T.; Cua, Daniel J.; Stohlman, Stephen A. title: Kinetics of Cytokine mRNA Expression in the Central Nervous System Following Lethal and Nonlethal Coronavirus-Induced Acute Encephalomyelitis date: 1997-07-07 journal: Virology DOI: 10.1006/viro.1997.8613 sha: doc_id: 268341 cord_uid: 103xf3dw file: cache/cord-271180-cnrs0zpg.json key: cord-271180-cnrs0zpg authors: Rizvi, Saniya; Danic, Michael; Silver, Mark; LaBond, Virginia title: Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? A case report. date: 2020-09-18 journal: Heart Lung DOI: 10.1016/j.hrtlng.2020.09.007 sha: doc_id: 271180 cord_uid: cnrs0zpg file: cache/cord-280821-kc0ut4oy.json key: cord-280821-kc0ut4oy authors: Venturini, Elisabetta; Montagnani, Carlotta; Garazzino, Silvia; Donà, Daniele; Pierantoni, Luca; Lo Vecchio, Andrea; Nicolini, Giangiacomo; Bianchini, Sonia; Krzysztofiak, Andrzej; Galli, Luisa; Villani, Alberto; Castelli-Gattinara, Guido title: Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease date: 2020-09-24 journal: Ital J Pediatr DOI: 10.1186/s13052-020-00900-w sha: doc_id: 280821 cord_uid: kc0ut4oy file: cache/cord-274497-tqceazdp.json key: cord-274497-tqceazdp authors: N. Nuñez, Luis Fabian; Santander-Parra, Silvana H.; De la Torre, David I.; de Sá, Lilian R. M.; Buim, Marcos R.; Astolfi-Ferreira, Claudete S.; Piantino Ferreira, Antonio J. title: Molecular Characterization and Pathogenicity of Chicken Parvovirus (ChPV) in Specific Pathogen-Free Chicks Infected Experimentally date: 2020-07-25 journal: Pathogens DOI: 10.3390/pathogens9080606 sha: doc_id: 274497 cord_uid: tqceazdp file: cache/cord-023017-k6edtg58.json key: cord-023017-k6edtg58 authors: nan title: AASLD Abstracts (pp. 282A–382A) date: 2006-02-10 journal: Hepatology DOI: 10.1002/hep.1840380505 sha: doc_id: 23017 cord_uid: k6edtg58 file: cache/cord-033453-557obi3r.json key: cord-033453-557obi3r authors: Bretscher, Lorenzo; Hsu, Alex; Simasek, Peter; Tamoni, Andrea title: COVID-19 and the Cross-Section of Equity Returns: Impact and Transmission date: 2020-09-24 journal: Rev Asset Pricing Stud DOI: 10.1093/rapstu/raaa017 sha: doc_id: 33453 cord_uid: 557obi3r file: cache/cord-265891-jmpterrj.json key: cord-265891-jmpterrj authors: Eilersen, Andreas; Sneppen, Kim title: Cost–benefit of limited isolation and testing in COVID-19 mitigation date: 2020-10-29 journal: Sci Rep DOI: 10.1038/s41598-020-75640-2 sha: doc_id: 265891 cord_uid: jmpterrj file: cache/cord-280242-2w2kl0uf.json key: cord-280242-2w2kl0uf authors: Kaya, Yildiz; Kara, Simay; Akinci, Canan; Kocaman, Ayse Sagduyu title: Transient cortical blindness in COVID-19 pneumonia; a PRES-like syndrome: A case report date: 2020-04-28 journal: J Neurol Sci DOI: 10.1016/j.jns.2020.116858 sha: doc_id: 280242 cord_uid: 2w2kl0uf file: cache/cord-006444-eq56zhtd.json key: cord-006444-eq56zhtd authors: nan title: Abstracts of oral presentations and posters date: 1993 journal: Ann Hematol DOI: 10.1007/bf01695978 sha: doc_id: 6444 cord_uid: eq56zhtd file: cache/cord-031315-p7jb4gf2.json key: cord-031315-p7jb4gf2 authors: Kong, Qing; Mo, Shuming; Wang, Wenqian; Tang, Zihui; Wei, Ying; Du, Yijie; Liu, Baojun; Kong, Lingwen; Lv, Yubao; Dong, Jingcheng title: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial date: 2020-09-03 journal: Trials DOI: 10.1186/s13063-020-04669-5 sha: doc_id: 31315 cord_uid: p7jb4gf2 file: cache/cord-006344-de4dhv4b.json key: cord-006344-de4dhv4b authors: Seitsonen, E.; Hynninen, M.; Kolho, E.; Kallio-Kokko, H.; Pettilä, V. title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection date: 2006-03-21 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s10096-006-0117-z sha: doc_id: 6344 cord_uid: de4dhv4b file: cache/cord-015090-n6f4xupw.json key: cord-015090-n6f4xupw authors: nan title: PS 339-563 date: 2005-09-10 journal: Intensive Care Med DOI: 10.1007/s00134-005-2780-4 sha: doc_id: 15090 cord_uid: n6f4xupw file: cache/cord-283257-rh3bxvv7.json key: cord-283257-rh3bxvv7 authors: Andrejčáková, Zuzana; Sopková, Drahomíra; Vlčková, Radoslava; Kulichová, Lucia; Gancarčíková, Soňa; Almášiová, Viera; Holovská, Katarína; Petrilla, Vladimír; Krešáková, Lenka title: Synbiotics suppress the release of lactate dehydrogenase, promote non‐specific immunity and integrity of jejunum mucosa in piglets date: 2015-12-21 journal: Anim Sci J DOI: 10.1111/asj.12558 sha: doc_id: 283257 cord_uid: rh3bxvv7 file: cache/cord-023100-0pqnsiid.json key: cord-023100-0pqnsiid authors: nan title: Abstract date: 2008-04-10 journal: J Small Anim Pract DOI: 10.1111/j.1748-5827.1991.tb00876.x sha: doc_id: 23100 cord_uid: 0pqnsiid file: cache/cord-268081-ytx6sf3x.json key: cord-268081-ytx6sf3x authors: Guionie, Olivier; Courtillon, Céline; Allee, Chantal; Maurel, Stéphan; Queguiner, Marilyne; Eterradossi, Nicolas title: An experimental study of the survival of turkey coronavirus at room temperature and +4°C date: 2013-04-22 journal: Avian Pathol DOI: 10.1080/03079457.2013.779364 sha: doc_id: 268081 cord_uid: ytx6sf3x file: cache/cord-274860-7ec2jcoq.json key: cord-274860-7ec2jcoq authors: Salazar, Eric; Christensen, Paul A.; Graviss, Edward A.; Nguyen, Duc T.; Castillo, Brian; Chen, Jian; Lopez, Bevin Valdez; Eagar, Todd N.; Yi, Xin; Zhao, Picheng; Rogers, John; Shehabeldin, Ahmed; Joseph, David; Masud, Faisal; Leveque, Christopher; Olsen, Randall J.; Bernard, David W.; Gollihar, Jimmy; Musser, James M. title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG date: 2020-11-04 journal: Am J Pathol DOI: 10.1016/j.ajpath.2020.10.008 sha: doc_id: 274860 cord_uid: 7ec2jcoq file: cache/cord-007456-acbo4zs2.json key: cord-007456-acbo4zs2 authors: Thomas, L.H.; Howard, C.J.; Parsons, K.R.; Anger, H.S. title: Growth of Mycoplasma bovis in organ cultures of bovine foetal trachea and comparison with Mycoplasma dispar date: 2002-11-13 journal: Vet Microbiol DOI: 10.1016/0378-1135(87)90044-7 sha: doc_id: 7456 cord_uid: acbo4zs2 file: cache/cord-018110-mcw4v13c.json key: cord-018110-mcw4v13c authors: Arnold, Andreas; Arnold, Wolfgang; Bovo, Roberto; Ganzer, Uwe; Hamann, Karl-Friedrich; Iurato, Salvatore; Kiefer, Jan; Lamm, Kerstin; Livi, Walter; Martini, Alessandro; O’Donoghue, Gerard M. title: Inner Ear date: 2010 journal: Otorhinolaryngology, Head and Neck Surgery DOI: 10.1007/978-3-540-68940-9_6 sha: doc_id: 18110 cord_uid: mcw4v13c file: cache/cord-032806-o6p861ms.json key: cord-032806-o6p861ms authors: Fenin, Audrey; Newman, Jill C.; Taylor, Sarah N. title: Very low birth weight infants receive full enteral nutrition within 2 postnatal weeks date: 2020-09-29 journal: J Perinatol DOI: 10.1038/s41372-020-00819-4 sha: doc_id: 32806 cord_uid: o6p861ms file: cache/cord-275427-00bwhaga.json key: cord-275427-00bwhaga authors: Aydogdu, Ugur; Coskun, Alparslan; Atas, Ahmet Duran; Basbug, Onur; Agaoglu, Zahid Tevfik title: The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis date: 2019-11-30 journal: Small Ruminant Research DOI: 10.1016/j.smallrumres.2019.09.021 sha: doc_id: 275427 cord_uid: 00bwhaga file: cache/cord-005816-i54q5gsu.json key: cord-005816-i54q5gsu authors: nan title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-009-8001-z sha: doc_id: 5816 cord_uid: i54q5gsu file: cache/cord-285096-g9y3au1a.json key: cord-285096-g9y3au1a authors: Mitchell, Judy A.; Brooks, Harriet W.; Szladovits, Balázs; Erles, Kerstin; Gibbons, Rachel; Shields, Shelly; Brownlie, Joe title: Tropism and pathological findings associated with canine respiratory coronavirus (CRCoV) date: 2013-03-23 journal: Vet Microbiol DOI: 10.1016/j.vetmic.2012.11.025 sha: doc_id: 285096 cord_uid: g9y3au1a file: cache/cord-276338-wpo1eyeg.json key: cord-276338-wpo1eyeg authors: Hesse, Amke; Wagner, Michael; Held, Jasmin; Brück, Wolfgang; Salinas-Riester, Gabriela; Hao, Zhenyue; Waisman, Ari; Kuhlmann, Tanja title: In toxic demyelination oligodendroglial cell death occurs early and is FAS independent date: 2009-10-22 journal: Neurobiol Dis DOI: 10.1016/j.nbd.2009.10.016 sha: doc_id: 276338 cord_uid: wpo1eyeg file: cache/cord-266156-xmf4emln.json key: cord-266156-xmf4emln authors: Miller, Tyler E.; Garcia Beltran, Wilfredo F.; Bard, Adam Z.; Gogakos, Tasos; Anahtar, Melis N.; Astudillo, Michael Gerino; Yang, Diane; Thierauf, Julia; Fisch, Adam S.; Mahowald, Grace K.; Fitzpatrick, Megan J.; Nardi, Valentina; Feldman, Jared; Hauser, Blake M.; Caradonna, Timothy M.; Marble, Hetal D.; Ritterhouse, Lauren L.; Turbett, Sara E.; Batten, Julie; Georgantas, Nicholas Zeke; Alter, Galit; Schmidt, Aaron G.; Harris, Jason B.; Gelfand, Jeffrey A.; Poznansky, Mark C.; Bernstein, Bradley E.; Louis, David N.; Dighe, Anand; Charles, Richelle C.; Ryan, Edward T.; Branda, John A.; Pierce, Virginia M.; Murali, Mandakolathur R.; Iafrate, A. John; Rosenberg, Eric S.; Lennerz, Jochen K. title: Clinical sensitivity and interpretation of PCR and serological COVID‐19 diagnostics for patients presenting to the hospital date: 2020-08-28 journal: FASEB J DOI: 10.1096/fj.202001700rr sha: doc_id: 266156 cord_uid: xmf4emln file: cache/cord-258696-01wj76es.json key: cord-258696-01wj76es authors: Decaro, Nicola; Campolo, Marco; Lorusso, Alessio; Desario, Costantina; Mari, Viviana; Colaianni, Maria Loredana; Elia, Gabriella; Martella, Vito; Buonavoglia, Canio title: Experimental infection of dogs with a novel strain of canine coronavirus causing systemic disease and lymphopenia date: 2008-04-30 journal: Vet Microbiol DOI: 10.1016/j.vetmic.2007.10.008 sha: doc_id: 258696 cord_uid: 01wj76es file: cache/cord-021555-rrverrsj.json key: cord-021555-rrverrsj authors: Delano, Margaret L.; Mischler, Scott A.; Underwood, Wendy J. title: Biology and Diseases of Ruminants: Sheep, Goats, and Cattle date: 2007-09-02 journal: Laboratory Animal Medicine DOI: 10.1016/b978-012263951-7/50017-x sha: doc_id: 21555 cord_uid: rrverrsj file: cache/cord-022659-chwk2bs4.json key: cord-022659-chwk2bs4 authors: nan title: Abstracts: Poster session date: 2004-10-08 journal: Ann Neurol DOI: 10.1002/ana.410320224 sha: doc_id: 22659 cord_uid: chwk2bs4 file: cache/cord-288051-wp8v2mc5.json key: cord-288051-wp8v2mc5 authors: Sánchez-González, Álvaro; López-Fando Lavalle, Luis; Esteban-Fernández, Alberto; Ruiz, Mercedes; Hevia, Vital; Comeche, Belén; Sánchez Conde, Matilde; Álvarez, Sara; Lorca Álvaro, Javier; Fraile Poblador, Agustín; Hevia Palacios, Manuel; Domínguez Gutiérrez, Ana; Artiles Medina, Alberto; Sanz Mayayo, Enrique; Duque, Gemma; Gómez Dos Santos, Victoria; Moreno-Guillén, Santiago; Burgos Revilla, Javier title: What Should Be Known by a Urologist About the Medical Management of COVID-19’s Patients? date: 2020-09-01 journal: Curr Urol Rep DOI: 10.1007/s11934-020-00995-y sha: doc_id: 288051 cord_uid: wp8v2mc5 file: cache/cord-292970-32mql9nq.json key: cord-292970-32mql9nq authors: Camdessanche, Jean-Philippe; Morel, Jérôme; Pozzetto, Bruno; Paul, Stéphane; Tholance, Yannick; Botelho-Nevers, Elisabeth title: COVID-19 may induce Guillain-Barré syndrome date: 2020-04-15 journal: Rev Neurol (Paris) DOI: 10.1016/j.neurol.2020.04.003 sha: doc_id: 292970 cord_uid: 32mql9nq file: cache/cord-275889-4qwp3um1.json key: cord-275889-4qwp3um1 authors: Guarnieri, M.; Brayton, C.; Sarabia-Estrada, R.; Tyler, B.; McKnight, P.; DeTolla, L. title: Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats date: 2017-04-09 journal: J Vet Med DOI: 10.1155/2017/3102567 sha: doc_id: 275889 cord_uid: 4qwp3um1 file: cache/cord-278224-sq7tokbx.json key: cord-278224-sq7tokbx authors: Protopopova, Alexandra; Hall, Nathaniel J.; Brown, Kelsea M.; Andrukonis, Allison S.; Hekman, Jessica P. title: Behavioral predictors of subsequent respiratory illness signs in dogs admitted to an animal shelter date: 2019-10-23 journal: PLoS One DOI: 10.1371/journal.pone.0224252 sha: doc_id: 278224 cord_uid: sq7tokbx file: cache/cord-287182-f0q8gfzc.json key: cord-287182-f0q8gfzc authors: Liao, Ji‐ping; Wang, Guang‐fa; Jin, Zhe; Qian, Yuan; Deng, Jie; Que, Cheng‐li title: Severe pneumonia caused by adenovirus 7 in pregnant woman: Case report and review of the literature date: 2016-06-21 journal: J Obstet Gynaecol Res DOI: 10.1111/jog.13036 sha: doc_id: 287182 cord_uid: f0q8gfzc file: cache/cord-006856-b1w25ob5.json key: cord-006856-b1w25ob5 authors: nan title: 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date: 2005 journal: Eur Surg DOI: 10.1007/s10353-005-0216-6 sha: doc_id: 6856 cord_uid: b1w25ob5 file: cache/cord-287520-51kmd2ds.json key: cord-287520-51kmd2ds authors: Carneiro, Arie; Wroclawski, Marcelo Langer; Nahar, Bruno; Soares, Andrey; Cardoso, Ana Paula; Kim, Nam Jin; Carvalho, Fabricio Torres title: Impact of the COVID-19 Pandemic on the Urologist’s clinical practice in Brazil: a management guideline proposal for low- and middle-income countries during the crisis period date: 2020-05-20 journal: Int Braz J Urol DOI: 10.1590/s1677-5538.ibju.2020.04.03 sha: doc_id: 287520 cord_uid: 51kmd2ds file: cache/cord-282158-08u3x1z4.json key: cord-282158-08u3x1z4 authors: Yang, William H.; Dionne, Marc; Kyle, Michael; Aggarwal, Naresh; Li, Ping; Madariaga, Miguel; Godeaux, Olivier; Vaughn, David W. title: Long-term immunogenicity of an AS03-adjuvanted influenza A(H1N1)pdm09 vaccine in young and elderly adults: An observer-blind, randomized trial() date: 2013-09-13 journal: Vaccine DOI: 10.1016/j.vaccine.2013.07.007 sha: doc_id: 282158 cord_uid: 08u3x1z4 file: cache/cord-295086-tc3re52f.json key: cord-295086-tc3re52f authors: Lu, Guoguang; Wang, Jing title: Dynamic changes in routine blood parameters of a severe COVID-19 case date: 2020-05-13 journal: Clin Chim Acta DOI: 10.1016/j.cca.2020.04.034 sha: doc_id: 295086 cord_uid: tc3re52f file: cache/cord-291315-y40s45iv.json key: cord-291315-y40s45iv authors: Logunov, Denis Y; Dolzhikova, Inna V; Zubkova, Olga V; Tukhvatullin, Amir I; Shcheblyakov, Dmitry V; Dzharullaeva, Alina S; Grousova, Daria M; Erokhova, Alina S; Kovyrshina, Anna V; Botikov, Andrei G; Izhaeva, Fatima M; Popova, Olga; Ozharovskaya, Tatiana A; Esmagambetov, Ilias B; Favorskaya, Irina A; Zrelkin, Denis I; Voronina, Daria V; Shcherbinin, Dmitry N; Semikhin, Alexander S; Simakova, Yana V; Tokarskaya, Elizaveta A; Lubenets, Nadezhda L; Egorova, Daria A; Shmarov, Maksim M; Nikitenko, Natalia A; Morozova, Lola F; Smolyarchuk, Elena A; Kryukov, Evgeny V; Babira, Vladimir F; Borisevich, Sergei V; Naroditsky, Boris S; Gintsburg, Alexander L title: Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia date: 2020-09-04 journal: Lancet DOI: 10.1016/s0140-6736(20)31866-3 sha: doc_id: 291315 cord_uid: y40s45iv file: cache/cord-277077-kwaiorp8.json key: cord-277077-kwaiorp8 authors: Tița, Ovidiu; Constantinescu, Maria Adelina; Tița, Mihaela Adriana; Georgescu, Cecilia title: Use of Yoghurt Enhanced with Volatile Plant Oils Encapsulated in Sodium Alginate to Increase the Human Body’s Immunity in the Present Fight Against Stress date: 2020-10-19 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17207588 sha: doc_id: 277077 cord_uid: kwaiorp8 file: cache/cord-282268-f7mbdfr6.json key: cord-282268-f7mbdfr6 authors: Cartenì, Armando; Di Francesco, Luigi; Martino, Maria title: How mobility habits influenced the spread of the COVID-19 pandemic: Results from the Italian case study date: 2020-06-24 journal: Sci Total Environ DOI: 10.1016/j.scitotenv.2020.140489 sha: doc_id: 282268 cord_uid: f7mbdfr6 file: cache/cord-295367-xhdki8jn.json key: cord-295367-xhdki8jn authors: McNally, D.; Simpson, M.; Morris, C.; Shephard, A.; Goulder, M. title: Rapid relief of acute sore throat with AMC/DCBA throat lozenges: randomised controlled trial date: 2009-10-22 journal: Int J Clin Pract DOI: 10.1111/j.1742-1241.2009.02230.x sha: doc_id: 295367 cord_uid: xhdki8jn file: cache/cord-007064-nepgttxf.json key: cord-007064-nepgttxf authors: Chemaly, Roy F; Dadwal, Sanjeet S; Bergeron, Anne; Ljungman, Per; Kim, Yae-Jean; Cheng, Guang-Shing; Pipavath, Sudhakar N; Limaye, Ajit P; Blanchard, Elodie; Winston, Drew J; Stiff, Patrick J; Zuckerman, Tsila; Lachance, Silvy; Rahav, Galia; Small, Catherine B; Mullane, Kathleen M; Patron, Roberto L; Lee, Dong-Gun; Hirsch, Hans H; Waghmare, Alpana; McKevitt, Matt; Jordan, Robert; Guo, Ying; German, Polina; Porter, Danielle P; Gossage, David L; Watkins, Timothy R; Marty, Francisco M; Chien, Jason W; Boeckh, Michael title: A Phase II, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients date: 2019-12-03 journal: Clin Infect Dis DOI: 10.1093/cid/ciz1166 sha: doc_id: 7064 cord_uid: nepgttxf file: cache/cord-005646-xhx9pzhj.json key: cord-005646-xhx9pzhj authors: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 journal: Intensive Care Med DOI: 10.1007/bf02316512 sha: doc_id: 5646 cord_uid: xhx9pzhj file: cache/cord-015126-cyhcbk1j.json key: cord-015126-cyhcbk1j authors: nan title: PS 0036-0344 date: 2007-08-25 journal: Intensive Care Med DOI: 10.1007/s00134-007-0820-y sha: doc_id: 15126 cord_uid: cyhcbk1j file: cache/cord-014538-6a2pviol.json key: cord-014538-6a2pviol authors: Kamilia, Chtara; Regaieg, Kais; Baccouch, Najeh; Chelly, Hedi; Bahloul, Mabrouk; Bouaziz, Mounir; Jendoubi, Ali; Abbes, Ahmed; Belhaouane, Houda; Nasri, Oussama; Jenzri, Layla; Ghedira, Salma; Houissa, Mohamed; Belkadi, Kamal; Harti, Youness; Nsiri, Afak; Khaleq, Khalid; Hamoudi, Driss; Harrar, Rachid; Thieffry, Camille; Wallet, Frédéric; Parmentier-Decrucq, Erika; Favory, Raphaël; Mathieu, Daniel; Poissy, Julien; Lafon, Thomas; Vignon, Philippe; Begot, Emmanuelle; Appert, Alexandra; Hadj, Mathilde; Claverie, Paul; Matt, Morgan; Barraud, Olivier; François, Bruno; Jamoussi, Amira; Jazia, Amira Ben; Marhbène, Takoua; Lakhdhar, Dhouha; Khelil, Jalila Ben; Besbes, Mohamed; Goutay, Julien; Blazejewski, Caroline; Joly-Durand, Isabelle; Pirlet, Isabelle; Weillaert, Marie Pierre; Beague, Sebastien; Aziz, Soufi; Hafiane, Reda; Hattabi, Khalid; Bouhouri, Mohamed Aziz; Hammoudi, Driss; Fadil, Abdelaziz; Harrar, Rachid Al; Zerouali, Khalid; Medhioub, Fatma Kaaniche; Allela, Rania; Algia, Najla Ben; Cherif, Samar; Slaoui, Mohamed Taoufik; Boubia, Souhail; Hafiani, Y.; Khaoudi, A.; Cherkab, R.; Elallam, W.; Elkettani, C.; Barrou, L.; Ridaii, M.; Mehdi, Rihi El; Schimpf, Caroline; Mizrahi, Assaf; Pilmis, Benoît; Le Monnier, Alban; Tiercelet, Kelly; Cherin, Mélanie; Bruel, Cédric; Philippart, Francois; Bailly, Sébastien; Lucet, Jc; Lepape, Alain; L’hériteau, François; Aupée, Martine; Bervas, Caroline; Boussat, Sandrine; Berger-Carbonne, Anne; Machut, Anaïs; Savey, Anne; Timsit, Jean-François; Razazi, Keyvan; Rosman, Jérémy; de Prost, Nicolas; Carteaux, Guillaume; Jansen, Chloe; Decousser, Jean Winoc; Brun-Buisson, Christian; Dessap, Armand Mekontso; M’rad, Aymen; Ouali, Zouhour; Barghouth, Manel; Kouatchet, Achille; Mahieu, Rafael; Weiss, Emmanuel; Schnell, David; Zahar, Jean-Ralph; Artiguenave, Margaux; Sophie, Paktoris-Papine; Espinasse, Florence; Sayed, Faten El; Dinh, Aurélien; Charron, Cyril; Geri, Guillaume; Vieillard-Baron, Antoine; Repessé, Xavier; Kallel, Hatem; Mayence, Claire; Houcke, Stéphanie; Guegueniat, Pascal; Hommel, Didier; Dhifaoui, Kaouther; Hajjej, Zied; Fatnassi, Amira; Sellami, Walid; Labbene, Iheb; Ferjani, Mustapha; Dachraoui, Fahmi; Nakkaa, Sabrine; M’ghirbi, Abdelwaheb; Adhieb, Ali; Braiek, Dhouha Ben; Hraiech, Kmar; Ousji, Ali; Ouanes, Islem; Zaineb, Hammouda; Abdallah, Saousen Ben; Ouanes-Besbes, Lamia; Abroug, Fekri; Klein, Simon; Miquet, Mattéo; Thouret, Jean-Marc; Peigne, Vincent; Daban, Jean-Louis; Boutonnet, Mathieu; Lenoir, Bernard; Merhbene, Takoua; Derreumaux, Celine; Seguin, Thierry; Conil, Jean-Marie; Kelway, Charlotte; Blasco, Valery; Nafati, Cyril; Harti, Karim; Reydellet, Laurent; Albanese, Jacques; Aicha, Narjess Ben; Meddeb, Khaoula; Khedher, Ahmed; Ayachi, Jihene; Fraj, Nesrine; Sma, Nesrine; Chouchene, Imed; Boussarsar, Mohamed; Yedder, Soumaya Ben; Samoud, Walid; Radhouene, Bousselmi; Mariem, Bousselmi; Ammar, Asma; Cheikh, Asma Ben; Lakhal, Hend Ben; Khelfa, Messaouda; Hamdaoui, Yamina; Bouafia, Nabiha; Trampont, Timothée; Daix, Thomas; Legarçon, Vincent; Karam, Henri Hani; Pichon, Nicolas; Essafi, Fatma; Foudhaili, Nasreddine; Thabet, Hafedh; Blel, Youssef; Brahmi, Nozha; Ezzouine, Hanane; Kerrous, Mahmoud; Haoui, Saad El; Ahdil, Soufiane; Benslama, Abdellatif; Abidi, Khalid; Dendane, Tarek; Oussama, Ssouni; Belayachi, Jihane; Madani, Naoufal; Abouqal, Redouane; Zeggwagh, Amine Ali; Ghadhoune, Hatem; Chaari, Anis; Jihene, Guissouma; Allouche, Hend; Trabelsi, Insaf; Brahmi, Habib; Samet, Mohamed; Ghord, Hatem El; Habiba, Ben Sik Ali; Hajer, Nouira; Tilouch, Najla; Yaakoubi, Sondes; Jaoued, Oussama; Gharbi, Rim; Hassen, Mohamed Fekih; Elatrous, Souheil; Arcizet, Julien; Leroy, Bertrand; Abdulmalack, Caroline; Renzullo, Catherine; Hamet, Maël; Doise, Jean-Marc; Coutet, Jérôme; Cheikh, Chaigar Mohammed; Quechar, Zakaria; Joris, Magalie; Beauport, Dimitri Titeca; Kontar, Loay; Lebon, Delphine; Gruson, Bérengère; Slama, Michel; Marolleau, Jean-Pierre; Maizel, Julien; Gorham, Julie; Ameye, Lieveke; Berghmans, Thierry; Paesmans, Marianne; Sculier, Jean-Paul; Meert, Anne-Pascale; Guillot, Max; Ledoux, Marie-Pierre; Braun, Thierry; Maestraggi, Quentin; Michard, Baptiste; Castelain, Vincent; Herbrecht, Raoul; Schneider, Francis; Couffin, Severine; Lobo, David; Mongardon, Nicolas; Dhonneur, Gilles; Mounier, Roman; Le Borgne, Pierrick; Couraud, Sophie; Herbrecht, Jean-Etienne; Boivin, Alexandra; Lefebvre, François; Bilbault, Pascal; Zelmat, Setti-Aouicha; Batouche, Djamila-Djahida; Mazour, Fatima; Chaffi, Belkacem; Benatta, Nadia; Sik, Ali Habiba; Talik, I.; Perrier, Maxime; Gouteix, Eliane; Koubi, Claude; Escavy, Annabelle; Guilbaut, Victoria; Fosse, Jean-Philippe; Jazia, Rahma Ben; Abdelghani, Ahmed; Cungi, Pierre-Julien; Bordes, Julien; Nguyen, Cédric; Pierrou, Candice; Cruc, Maximilien; Benois, Alain; Duprez, Frédéric; Bonus, Thierry; Cuvelier, Grégory; Ollieuz, Sandra; Machayekhi, Sharam; Paciorkowski, Frédéric; Reychler, Gregory; Coudroy, Remi; Thille, Arnaud W.; Drouot, Xavier; Diaz, Véronique; Meurice, Jean-Claude; Robert, René; Turki, Olfa; Ben, Hmida Chokri; Assefi, Mona; Deransy, Romain; Brisson, Hélène; Monsel, Antoine; Conti, Filomena; Scatton, Olivier; Langeron, Olivier; Ghezala, Hassen Ben; Snouda, Salah; Ben, Chiekh Imen; Kaddour, Moez; Armel, Anwar; Youness, Lafrikh; Abdelhak, Bensaid; Youssef, Miloudi; Najib, Al Harrar; Mustapha, Amouzoun; Noufel, Mtioui; Mohamed, Zamd; Salma, El Khayat; Ghizlane, Medkouri; Mohamed, Benghanam; Benyounes, Ramdani; Montini, Florent; Moschietto, Sébastien; Gregoire, Emilien; Claisse, Guillaume; Guiot, Julien; Morimont, Philippe; Krzesinski, Jean-Marie; Mariat, Christophe; Lambermont, Bernard; Cavalier, Etienne; Delanaye, Pierre; Benbernou, Soumia; Ilies, Sofiane; Azza, Abdelkader; Bouyacoub, Khalida; Louail, Meriem; Mokhtari-Djebli, Houria; Arrestier, Romain; Daviaud, Fabrice; Francois, Xavier Laborne; Brocas, Elsa; Choukroun, Gérald; Peñuelas, Oscar; Lorente, José-Angel; Cardinal-Fernandez, Pablo; Rodriguez, José-Maria; Aramburu, José-Antonio; Esteban, Andres; Frutos-Vivar, Fernando; Bitker, Laurent; Costes, Nicolas; Le Bars, Didier; Lavenne, Franck; Devouassoux, Mojgan; Richard, Jean-Christophe; Mechati, Malika; Gainnier, Marc; Papazian, Laurent; Guervilly, Christophe; Garnero, Aude; Arnal, Jean Michel; Roze, Hadrien; Richard, Jean Christophe; Repusseau, Benjamin; Dewitte, Antoine; Joannes-Boyau, Olivier; Ouattara, Alexandre; Harbouze, Nadia; Amine, A. M.; Olandzobo, A. G.; Herbland, Alexandre; Richard, Marie; Girard, Nicolas; Lambron, Lucile; Lesieur, Olivier; Wainschtein, Sarah; Hubert, Sidonie; Hugues, Albane; Tran, Marc; Bouillard, Philippe; Loteanu, Vlad; Leloup, Maxime; Laurent, Alexandra; Lheureux, Florent; Prestifilippo, Alessia; Cruz, Martin Delgado Maria; Romain, Rigal; Antonelli, Massimo; Blanch, Torra Lluis; Bonnetain, Franck; Grazzia-Bocci, Maria; Mancebo, Jordi; Samain, Emmanuel; Paul, Hebert; Capellier, Gilles; Zavgorodniaia, Taissa; Soichot, Marion; Malissin, Isabelle; Voicu, Sebastian; Garçon, Pierre; Goury, Antoine; Kerdjana, Lamia; Deye, Nicolas; Bourgogne, Emmanuel; Megarbane, Bruno; Mejri, Olfa; Hmida, Marwa Ben; Tannous, Salma; Chevillard, Lucie; Labat, Laurence; Risede, Patricia; Fredj, Hana; Léger, Maxime; Brunet, Marion; Le Roux, Gaël; Boels, David; Lerolle, Nicolas; Farah, Souaad; Amiel-Niemann, Hélène; Kubis, Nathalie; Declèves, Xavier; Peyraux, Nicoals; Baud, Frederic; Serafini, Micaela; Alvarez, Jean-Claude; Heinzelman, Annette; Jozwiak, Mathieu; Millasseau, Sandrine; Teboul, Jean-Louis; Alphonsine, Jean-Emmanuel; Depret, François; Richard, Nathalie; Attal, Pierre; Richard, Christian; Monnet, Xavier; Chemla, Denis; Jerbi, Salma; Khedhiri, Wafa; Necib, Hatem; Scarfo, Paolo; Chevalier, Charles; Piagnerelli, Michael; Lafont, Alexandre; Galy, Antoine; Mancia, Claire; Zerhouni, Amel; Tabeliouna, Kheira; Gaja, Ali; Hamrouni, Bassem; Malouch, Abir; Fourati, Sami; Messaoud, Rihab; Zarrouki, Youssef; Ziadi, Amra; Rhezali, Manal; Zouizra, Zahira; Boumzebra, Drissi; Samkaoui, Mohamed Abdennasser; Brunet, Jennifer; Canoville, Bertrand; Verrier, Pierre; Ivascau, Calin; Seguin, Amélie; Valette, Xavier; Du Cheyron, Damien; Daubin, Cedric; Bougouin, Wulfran; Aissaoui, Nadia; Lamhaut, Lionel; Jost, Daniel; Maupain, Carole; Beganton, Frankie; Bouglé, Adrien; Dumas, Florence; Marijon, Eloi; Jouven, Xavier; Cariou, Alain; Poirson, Florent; Chaput, Ulriikka; Beeken, Thomas; Maxime, Leclerc; Haikel, Oueslati; Vodovar, Dominique; Chelly, Jonathan; Marteau, Philippe; Chocron, Richard; Juvin, Philippe; Loeb, Thomas; Adnet, Frederic; Lecarpentier, Eric; Riviere, Antoine; De Cagny, Bertand; Soupison, Thierry; Privat, Elodie; Escutnaire, Joséphine; Dumont, Cyrielle; Baert, Valentine; Vilhelm, Christian; Hubert, Hervé; Leteurtre, Stéphane; Fresco, Marion; Bubenheim, Michael; Beduneau, Gaetan; Carpentier, Dorothée; Grange, Steven; Artaud-Macari, Elise; Misset, Benoit; Tamion, Fabienne; Girault, Christophe; Dumas, Guillaume; Chevret, Sylvie; Lemiale, Virginie; Mokart, Djamel; Mayaux, Julien; Pène, Frédéric; Nyunga, Martine; Perez, Pierre; Moreau, Anne-Sophie; Bruneel, Fabrice; Vincent, François; Klouche, Kada; Reignier, Jean; Rabbat, Antoine; Azoulay, Elie; Frat, Jean-Pierre; Ragot, Stéphanie; Constantin, Jean-Michel; Prat, Gwenael; Mercat, Alain; Boulain, Thierry; Demoule, Alexandre; Devaquet, Jérôme; Nseir, Saad; Charpentier, Julien; Argaud, Laurent; Beuret, Pascal; Ricard, Jean-Damien; Teiten, Christelle; Marjanovic, Nicolas; Palamin, Nicola; L’Her, Erwan; Bailly, Arthur; Boisramé-Helms, Julie; Champigneulle, Benoit; Kamel, Toufik; Mercier, Emmanuelle; Le Thuaut, Aurélie; Lascarrou, Jean-Baptiste; Rolle, Amélie; De Jong, Audrey; Chanques, Gérald; Jaber, Samir; Hariri, Geoffroy; Baudel, Jean-Luc; Dubée, Vincent; Preda, Gabriel; Bourcier, Simon; Joffre, Jeremie; Bigé, Naïke; Ait-Oufella, Hafid; Maury, Eric; Mater, Houda; Merdji, Hamid; Grimaldi, David; Rousseau, Christophe; Mira, Jean-Paul; Chiche, Jean-Daniel; Sedghiani, Ines; Benabderrahim, A.; Hamdi, Dhekra; Jendoubi, Asma; Cherif, Mohamed Ali; Hechmi, Youssef Zied El; Zouheir, Jerbi; Bagate, François; Bousselmi, Radhwen; Schortgen, Frédérique; Asfar, Pierre; Guérot, Emmanuel; Fabien, Grelon; Anguel, Nadia; Sigismond, Lasocki; Matthieu, Henry-Lagarrigue; Gonzalez, Frédéric; François, Legay; Guitton, Christophe; Schenck, Maleka; Jean-Marc, Doise; Dreyfuss, Didier; Radermacher, Peter; Frère, Antoine; Martin-Lefèvre, Laurent; Colin, Gwenhaël; Fiancette, Maud; Henry-Laguarrigue, Matthieu; Lacherade, Jean-Claude; Lebert, Christine; Vinatier, Isabelle; Yehia, Aihem; Joret, Aurélie; Menunier-Beillard, Nicolas; Benzekri-Lefevre, Dalila; Desachy, Arnaud; Bellec, Fréderic; Plantefève, Gaëtan; Quenot, Jean-Pierre; Meziani, Ferhat; Tavernier, Elsa; Ehrmann, Stephan; Chudeau, Nicolas; Raveau, Tommy; Moal, Valérie; Houillier, Pascal; Rouve, Emmanuelle; Lakhal, Karim; Gandonnière, Charlotte Salmon; Jouan, Youenn; Bodet-Contentin, Laetitia; Balmier, Adrien; Messika, Jonathan; De Montmollin, Etienne; Pouyet, Victorine; Sztrymf, Benjamin; Thiagarajah, Abirami; Roux, Damien; De Chambrun, Marc Pineton; Luyt, Charles-Edouard; Beloncle, François; Zapella, Nathalie; Ledochowsky, Stanislas; Terzi, Nicolas; Mazou, Jean-Marc; Sonneville, Romain; Paulus, Sylvie; Fedun, Yannick; Landais, Mickael; Raphalen, Jean-Herlé; Combes, Alain; Amoura, Zahir; Jacquemin, Aemilia; Guerrero, Felipe; Marcheix, Bertrand; Hernandez, Nicolas; Fourcade, Olivier; Georges, Bernard; Delmas, Clément; Makoudi, Sarah; Genton, Audrey; Bernard, Rémy; Lebreton, Guillaume; Amour, Julien; Mazet, Charlotte; Bounes, Fanny; Murat, Gurbuz; Cronier, Laure; Robin, Guillaume; Biendel, Caroline; Silva, Stein; Boubeche, Samia; Abriou, Caroline; Wurtz, Véronique; Scherrer, Vincent; Rey, Nathalie; Gastaldi, Gioia; Veber, Benoit; Doguet, Fabien; Gay, Arnaud; Dureuil, Bertrand; Besnier, Emmanuel; Rouget, Antoine; Gantois, Guillaume; Magalhaes, Eric; Wanono, Ruben; Smonig, Roland; Lermuzeaux, Mathilde; Lebut, Jordane; Olivier, Andremont; Dupuis, Claire; Radjou, Aguila; Mourvillier, Bruno; Neuville, Mathilde; D’ortho, Marie Pia; Bouadma, Lila; Rouvel-Tallec, Anny; Rudler, Marika; Weiss, Nicolas; Perlbarg, Vincent; Galanaud, Damien; Thabut, Dominique; Rachdi, Emna; Mhamdi, Ghada; Trifi, Ahlem; Abdelmalek, Rim; Abdellatif, Sami; Daly, Foued; Nasri, Rochdi; Tiouiri, Hanene; Lakhal, Salah Ben; Rousseau, Geoffroy; Asmolov, Romain; Grammatico-Guillon, Leslie; Auvet, Adrien; Laribi, Said; Garot, Denis; Dequin, Pierre François; Guillon, Antoine; Fergé, Jean-Louis; Abgrall, Gwénolé; Hinault, Ronan; Vally, Shazima; Roze, Benoit; Chaplain, Agathe; Chabartier, Cyrille; Savidan, Anne-Charlotte; Marie, Sabia; Cabie, Andre; Resiere, Dabor; Valentino, Ruddy; Mehdaoui, Hossein; Benarous, Lucas; Soda-Diop, Marième; Bouzana, Fouad; Perrin, Gilles; Bourenne, Jeremy; Eon, Béatrice; Lambert, Dominique; Trebuchon, Agnes; Poncelet, Géraldine; Le Bourgeois, Fleur; Michael, Levy; Camille, Guillot; Naudin, Jérôme; Deho, Anna; Dauger, Stéphane; Sauthier, Michaël; Bergeron-Gallant, Krystale; Emeriaud, Guillaume; Jouvet, Philippe; Tiebergien, Nicolas; Jacquet-Lagrèze, Matthias; Fellahi, Jean-Luc; Baudin, Florent; Essouri, Sandrine; Javouhey, Etienne; Guérin, Claude; Lampin, Marie; Mamouri, Ouardia; Devos, Patrick; Karaca-Altintas, Yasemin; Vinchon, Matthieu; Brossier, David; Eltaani, Redha; Teyssedre, Sonia; Sabine, Meyet; Bouchut, Jean-Christophe; Peguet, Olivier; Petitdemange, Lucie; Guilbert, Anne Sophie; Aoul, Nabil Tabet; Addou, Zakaria; Aouffen, Nabil; Anas, Benqqa; Kalouch, Samira; Yaqini, Khalid; Chlilek, Aziz; Abdou, Rchi; Gravellier, Perrine; Chantreuil, Julie; Travers, Nadine; Listrat, Antoine; Le Reun, Claire; Favrais, Geraldine; Coppere, Zoe; Blanot, Stéphane; Montmayeur, Juliette; Bronchard, Régis; Rolando, Stephane; Orliaguet, Gilles; Leger, Pierre-Louis; Rambaud, Jérôme; Thueux, Emilie; De Larrard, Alexandra; Berthelot, Véronique; Denot, Julien; Reymond, Marie; Amblard, Alain; Morin-Zorman, Sarah; Lengliné, Etienne; Pichereau, Claire; Mariotte, Eric; Emmanuel, Canet; Poujade, Julien; Trumpff, Guillaume; Janssen-Langenstein, Ralf; Harlay, Marie-Line; Zaid, Noorah; Ait-Ammar, Nawel; Bonnal, Christine; Merle, Jean-Claude; Botterel, Francoise; Levesque, Eric; Riad, Zakaria; Mezidi, Mehdi; Yonis, Hodane; Aublanc, Mylène; Perinel-Ragey, Sophie; Lissonde, Floriane; Louf-Durier, Aurore; Tapponnier, Romain; Louis, Bruno; Forel, Jean-Marie; Bisbal, Magali; Lehingue, Samuel; Rambaud, Romain; Adda, Mélanie; Hraiech, Sami; Marchi, Elisa; Roch, Antoine; Guerin, Vincent; Rozencwajg, Sacha; Schmidt, Matthieu; Hekimian, Guillaume; Bréchot, Nicolas; Trouillet, Jean Louis; Besset, Sébastien; Franchineau, Guillaume; Nieszkowska, Ania; Pascal, Leprince; Loiselle, Maud; Sarah, Chemam; Laurence, Dangers; Guillemette, Thomas; Jacquens, Alice; Kerever, Sebastien; Guidet, Bertrand; Aegerter, Philippe; Das, Vincent; Fartoukh, Muriel; Hayon, Jan; Desmard, Mathieu; Fulgencio, Jean-Pierre; Zuber, Benjamin; Soufi, A.; Khaleq, K.; Hamoudi, D.; Garret, Charlotte; Peron, Matthieu; Coron, Emmanuel; Bretonnière, Cédric; Audureau, Etienne; Audrey, Winters; Christophe, Duvoux; Christian, Jacquelinet; Daniel, Azoulay; Cyrille, Feray; Aissaoui, Wissal; Rghioui, Kawtar; Haddad, Wafae; Barrou, Houcine; Carteaux-Taeib, Anna; Lupinacci, Renato; Manceau, Gilles; Jeune, Florence; Tresallet, Christophe; Habacha, Sahar; Fathallah, Ines; Zoubli, Aymen; Aloui, Rafaa; Kouraichi, Nadia; Jouet, Emilie; Badin, Julie; Fermier, Brice; Feller, Marc; Serie, Mathieu; Pillot, Jérôme; Marie, William; Gisbert-Mora, Chloé; Vinclair, Camille; Lesbordes, Pierre; Mathieu, Pascal; De Brabant, Fabienne; Muller, Emmanuel; Robaux, Marie-Aline; Giabicani, Mikhael; Marchalot, Antoine; Gelinotte, Stéphanie; Declercq, Pierre Louis; Eraldi, Jean-Pierre; Bougerol, François; Meunier-Beillard, Nicolas; Devilliers, Hervé; Rigaud, Jean-Philippe; Verrière, Camille; Ardisson, Fanny; Kentish-Barnes, Nancy; Jacq, Gwenaëlle; Chermak, Akli; Lautrette, Alexandre; Legrand, Matthieu; Soummer, Alexis; Thiery, Guillaume; Cottereau, Alice; Canet, Emmanuel; Caujolle, Marie; Allyn, Jérôme; Valance, Dorothée; Brulliard, Caroline; Martinet, Olivier; Jabot, Julien; Gallas, Thomas; Vandroux, David; Allou, Nicolas; Durand, Arthur; Nevière, Rémi; Delguste, Florian; Boulanger, Eric; Preau, Sebastien; Martin, Ruste; Cochet, Hélène; Ponthus, Jean Pierre; Amilien, Virginie; Tchir, Martial; Barsam, Elise; Ayoub, Mohsen; Georger, Jean Francois; Guillame, Izaute; Assaraf, Julie; Tripon, Simona; Mallet, Maxime; Barbara, Guilaume; Louis, Guillaume; Gaudry, Stéphane; Barbarot, Nicolas; Jamet, Angéline; Outin, Hervé; Gibot, Sébastien; Bollaert, Pierre-Edouard; Holleville, Mathilde; Legriel, Stéphane; Chateauneuf, Anne Laure; Cavelot, Sébastien; Moyer, Jean-Denis; Bedos, Jean Pierre; Merle, Philippe; Laine, Aurelie; Natalie, De Sa; Cornuault, Mathieu; Libot, Jérome; Asehnoune, Karim; Rozec, Bertrand; Dantal, Jacques; Videcoq, Michel; Degroote, Thècle; Jaillette, Emmanuelle; Zerimech, Farid; Malika, Balduyck; Llitjos, Jean-François; Amara, Marlène; Lacave, Guillaume; Pangon, Béatrice; Mavinga, José; Makunza, Joseph Nsiala; Mafuta, M. E.; Yanga, Yves; Eric, Amisi; Ilunga, Jp; Kilembe, Ma; Alby-Laurent, Fanny; Toubiana, Julie; Mokline, Amel; Laajili, Achraf; Amri, Helmi; Rahmani, Imene; Mensi, Nidhal; Gharsallah, Lazheri; Tlaili, Sofiene; Gasri, Bahija; Hammouda, Rym; Messadi, Amen Allah; Allain, Pierre-Antoine; Gault, Nathallie; Paugam-Burtz, Catherine; Foucrier, Arnaud; Chatbri, Bassem; Bourbiaa, Yousra; Thabet, Lamia; Neuschwander, Arthur; Vincent, Looten; Beck, Jennifer; Vibol, Chhor; Amelie, Yavchitz; Resche-Rigon, Matthieu; Pirracchio, Jean MantzRomain; Bureau, Côme; Decavèle, Maxens; Campion, Sébastien; Ainsouya, Roukia; Niérat, Marie-Cécile; Prodanovic, Hélène; Raux, Mathieu; Similowski, Thomas; Dubé, Bruno-Pierre; Demiri, Suela; Dres, Martin; May, Faten; Quintard, Hervé; Kounis, Ilias; Saliba, Faouzi; André, Stephane; Boudon, Marc; Ichai, Philippe; Younes, Aline; Nakad, Lionel; Coilly, Audrey; Antonini, Teresa; Sobesky, Rodolphe; De Martin, Eleonora; Samuel, Didier; Hubert, Noemie; Nay, Mai-Anh; Auchabie, Johann; Giraudeau, Bruno; Jean, Reignier; Darmon, Michaël; Ruckly, Stephane; Garrouste-Orgeas, Maïté; Gratia, Elisabeth; Goldgran-Toledano, Dany; Jamali, Samir; Dumenil, Anne Sylvie; Schwebel, Carole; Brisard, Laurent; Bizouarn, Philippe; Lepoivre, Thierry; Nicolet, Johanna; Rigal, Jean Christophe; Roussel, Jean Christian; Cheurfa, Cherifa; Abily, Julien; Lescot, Thomas; Page, Isaline; Warnier, Stéphanie; Nys, Monique; Rousseau, Anne-Françoise; Damas, Pierre; Uhel, Fabrice; Lesouhaitier, Mathieu; Grégoire, Murielle; Gaudriot, Baptiste; Gacouin, Arnaud; Le Tulzo, Yves; Flecher, Erwan; Tarte, Karin; Tadié, Jean-Marc; Georges, Quentin; Soares, M.; Jeon, Kyeongman; Oeyen, Sandra; Rhee, Chin Kook; Gruber, Pascale; Ostermann, Marlies; Hill, Quentin; Depuydt, Peter; Ferra, Christelle; Muller, Alice; Aurelie, Bourmaud; Niles, Christopher; Herbert, Fabien; Pied, Sylviane; Loridant, Séverine; François, Nadine; Bignon, Anne; Sendid, Boualem; Lemaitre, Caroline; Dupre, Celine; Zayene, Aymen; Portier, Lucie; De Freitas Caires, Nathalie; Lassalle, Philippe; Le Neindre, Aymeric; Selot, Pascal; Ferreiro, Daniel; Bonarek, Maria; Henriot, Stépahen; Rodriguez, Julie; Taddei, Mara; Di Bari, Mauro; Hickmann, Cheryl; Castanares-Zapatero, Diego; Deldicque, Louise; Van Den Bergh, Peter; Caty, Gilles; Roeseler, Jean; Francaux, Marc; Laterre, Pierre-François; Dupuis, Bastien; Machayeckhi, Sharam; Sarfati, Celine; Moore, Alex; Mendialdua, Paula; Rodet, Emilie; Pilorge, Catherine; Stephan, Francois; Rezaiguia-Delclaux, Saida; Dugernier, Jonathan; Hesse, Michel; Jumetz, Thibaud; Bialais, Emilie; Depoortere, Virginie; Michotte, Jean Bernard; Wittebole, Xavier; Jamar, François title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 journal: Ann Intensive Care DOI: 10.1186/s13613-016-0224-7 sha: doc_id: 14538 cord_uid: 6a2pviol file: cache/cord-005478-5iu38pr6.json key: cord-005478-5iu38pr6 authors: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session date: 2019-07-03 journal: Bone Marrow Transplant DOI: 10.1038/s41409-019-0562-9 sha: doc_id: 5478 cord_uid: 5iu38pr6 file: cache/cord-285812-l7dpv6nx.json key: cord-285812-l7dpv6nx authors: O’TOOLE, D.; BROWN, I.; BRIDGES, A.; CARTWRIGHT, S. F. title: Pathogenicity of experimental infection with ‘pneumotropic’ porcine coronavirus date: 1989-07-31 journal: Research in Veterinary Science DOI: 10.1016/s0034-5288(18)31226-8 sha: doc_id: 285812 cord_uid: l7dpv6nx file: cache/cord-015024-2xzc0uc5.json key: cord-015024-2xzc0uc5 authors: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 journal: Intensive Care Med DOI: 10.1007/s00134-010-2001-7 sha: doc_id: 15024 cord_uid: 2xzc0uc5 file: cache/cord-295633-vkjcheaz.json key: cord-295633-vkjcheaz authors: Hao, Xin‐yan; Lv, Qi; Li, Feng‐di; Xu, Yan‐feng; Gao, Hong title: The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose‐only exposure device date: 2019-10-30 journal: Animal Model Exp Med DOI: 10.1002/ame2.12088 sha: doc_id: 295633 cord_uid: vkjcheaz file: cache/cord-015369-72cjogxz.json key: cord-015369-72cjogxz authors: nan title: 50th Annual Meeting of the Austrian Society of Surgery. Vienna, June 18–20, 2009. Guest Editors: Albert Tuchmann, Erhard Schwanzer, Benedikt Walzel date: 2009 journal: Eur Surg DOI: 10.1007/s10353-009-0461-1 sha: doc_id: 15369 cord_uid: 72cjogxz file: cache/cord-006182-kck5e1ry.json key: cord-006182-kck5e1ry authors: nan title: 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date: 2019-10-01 journal: Neurocrit Care DOI: 10.1007/s12028-019-00857-7 sha: doc_id: 6182 cord_uid: kck5e1ry file: cache/cord-014976-546zaoxn.json key: cord-014976-546zaoxn authors: nan title: Publication only date: 2006-03-08 journal: Bone Marrow Transplant DOI: 10.1038/sj.bmt.1705327 sha: doc_id: 14976 cord_uid: 546zaoxn file: cache/cord-006880-9dgmdtj8.json key: cord-006880-9dgmdtj8 authors: nan title: Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date: 2012-09-19 journal: Neurocrit Care DOI: 10.1007/s12028-012-9775-0 sha: doc_id: 6880 cord_uid: 9dgmdtj8 file: cache/cord-300570-xes201g7.json key: cord-300570-xes201g7 authors: Patwardhan, J. title: PREDICTIONS FOR EUROPE FOR THE COVID-19 PANDEMICAFTER LOCKDOWN WAS LIFTED USING AN SIR MODEL date: 2020-10-06 journal: nan DOI: 10.1101/2020.10.03.20206359 sha: doc_id: 300570 cord_uid: xes201g7 file: cache/cord-295703-no45mgyd.json key: cord-295703-no45mgyd authors: ALTAY, O.; YANG, H.; AYDIN, M.; Alkurt, G.; ALTUNAL, N.; KIM, W.; AKYOL, D.; ARIF, M.; Zhang, C.; Dinler-Doganay, G.; TURKEZ, H.; SHOAIE, S.; NIELSEN, J.; BOREN, J.; DOGANAY, L.; UHLEN, M.; Mardinoglu, A. title: Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 date: 2020-10-05 journal: nan DOI: 10.1101/2020.10.02.20202614 sha: doc_id: 295703 cord_uid: no45mgyd file: cache/cord-014464-m5n250r2.json key: cord-014464-m5n250r2 authors: Sole-Violan, J; Sologuren, I; Betancor, E; Zhang, S; Pérez, C; Herrera-Ramos, E; Martínez-Saavedra, M; López-Rodríguez, M; Pestano, J; Ruiz-Hernández, J; Ferrer, J; Rodríguez de Castro, F; Casanova, J; Rodríguez-Gallego, C title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 journal: Crit Care DOI: 10.1186/cc11953 sha: doc_id: 14464 cord_uid: m5n250r2 file: cache/cord-275828-c6d6nk7x.json key: cord-275828-c6d6nk7x authors: Mikasa, Keiichi; Aoki, Nobuki; Aoki, Yosuke; Abe, Shuichi; Iwata, Satoshi; Ouchi, Kazunobu; Kasahara, Kei; Kadota, Junichi; Kishida, Naoki; Kobayashi, Osamu; Sakata, Hiroshi; Seki, Masahumi; Tsukada, Hiroki; Tokue, Yutaka; Nakamura-Uchiyama, Fukumi; Higa, Futoshi; Maeda, Koichi; Yanagihara, Katsunori; Yoshida, Koichiro title: JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date: 2016-07-31 journal: Journal of Infection and Chemotherapy DOI: 10.1016/j.jiac.2015.12.019 sha: doc_id: 275828 cord_uid: c6d6nk7x file: cache/cord-299343-gsrgf4dd.json key: cord-299343-gsrgf4dd authors: Wilson, A. M.; Aviles, N.; Beamer, P. I.; Szabo, Z.; Ernst, K. C.; Masel, J. title: Quantifying SARS-CoV-2 infection risk within the Apple/Google exposure notification framework to inform quarantine recommendations date: 2020-07-19 journal: nan DOI: 10.1101/2020.07.17.20156539 sha: doc_id: 299343 cord_uid: gsrgf4dd file: cache/cord-005497-w81ysjf9.json key: cord-005497-w81ysjf9 authors: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 journal: Crit Care DOI: 10.1186/s13054-020-2772-3 sha: doc_id: 5497 cord_uid: w81ysjf9 file: cache/cord-306705-adshd3jj.json key: cord-306705-adshd3jj authors: Lenander-Lumikari, Marianne; Puhakka, Tuomo; Mäkelä, Mika J.; Vilja, Pekka; Ruuskanen, Olli; Tenovuo, Jorma title: Effects of the common cold and intranasal fluticasone propionate treatment on mucosal host defense assessed by human saliva()()() date: 2005-11-04 journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod DOI: 10.1016/s1079-2104(99)70163-0 sha: doc_id: 306705 cord_uid: adshd3jj file: cache/cord-309588-kw4d32dt.json key: cord-309588-kw4d32dt authors: Chan, Michael H.M.; Chan, Paul K.S.; Griffith, James F.; Chan, Iris H.S.; Lit, Lydia C.W.; Wong, C. K.; Antonio, Gregory E.; Liu, Ester Y.M.; Hui, David S.C.; Suen, Michael W.M; Ahuja, Anil T.; Y. Sung, Joseph J.; K. Lam, Christopher W. title: Steroid-induced osteonecrosis in severe acute respiratory syndrome: a retrospective analysis of biochemical markers of bone metabolism and corticosteroid therapy date: 2006-06-30 journal: Pathology DOI: 10.1080/00313020600696231 sha: doc_id: 309588 cord_uid: kw4d32dt file: cache/cord-005727-li8pwigg.json key: cord-005727-li8pwigg authors: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 journal: Intensive Care Med DOI: 10.1007/s00134-010-1999-x sha: doc_id: 5727 cord_uid: li8pwigg file: cache/cord-310249-cvv77f10.json key: cord-310249-cvv77f10 authors: Yule, Terecita D.; Roth, Mark B.; Dreier, Kimberly; Johnson, Anthony F.; Palmer-Densmore, Melissa; Simmons, Kris; Fanton, Robert title: Canine parvovirus vaccine elicits protection from the inflammatory and clinical consequences of the disease date: 1997-05-31 journal: Vaccine DOI: 10.1016/s0264-410x(96)00232-0 sha: doc_id: 310249 cord_uid: cvv77f10 file: cache/cord-304562-5xh4p786.json key: cord-304562-5xh4p786 authors: Tanabe, Naoya; Matsumoto, Hisako; Hamada, Satoshi; Ito, Isao; Hirai, Toyohiro title: Dupilumab maintenance therapy in an asthmatic patient with coronavirus disease 2019 pneumonia date: 2020-11-07 journal: Allergol Int DOI: 10.1016/j.alit.2020.10.005 sha: doc_id: 304562 cord_uid: 5xh4p786 file: cache/cord-314235-08z2jyzd.json key: cord-314235-08z2jyzd authors: Matzinger, P.; Skinner, J. title: Strong impact of closing schools, closing bars and wearing masks during the Covid-19 pandemic: results from a simple and revealing analysis date: 2020-09-28 journal: medRxiv : the preprint server for health sciences DOI: 10.1101/2020.09.26.20202457 sha: doc_id: 314235 cord_uid: 08z2jyzd file: cache/cord-303878-v2n9jeeb.json key: cord-303878-v2n9jeeb authors: Stiles, Jonathan; Smart, Michael J. title: Working at home and elsewhere: daily work location, telework, and travel among United States knowledge workers date: 2020-09-05 journal: Transportation (Amst) DOI: 10.1007/s11116-020-10136-6 sha: doc_id: 303878 cord_uid: v2n9jeeb file: cache/cord-301947-b6nwaost.json key: cord-301947-b6nwaost authors: Millán-Oñate, José; Millan, William; Mendoza, Luis Alfonso; Sánchez, Carlos Guillermo; Fernandez-Suarez, Hugo; Bonilla-Aldana, D. Katterine; Rodríguez-Morales, Alfonso J. title: Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin date: 2020-04-24 journal: Ann Clin Microbiol Antimicrob DOI: 10.1186/s12941-020-00358-y sha: doc_id: 301947 cord_uid: b6nwaost file: cache/cord-006870-f5w6fw6q.json key: cord-006870-f5w6fw6q authors: nan title: Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting date: 2017-09-19 journal: Neurocrit Care DOI: 10.1007/s12028-017-0465-9 sha: doc_id: 6870 cord_uid: f5w6fw6q file: cache/cord-300810-a1skdp67.json key: cord-300810-a1skdp67 authors: Lafay, F.; Coulon, P.; Astic, L.; Saucier, D.; Riche, D.; Holley, A.; Flamand, A. title: Spread of the CVS strain of rabies virus and of the avirulent mutant AvO1 along the olfactory pathways of the mouse after intranasal inoculation date: 1991-07-31 journal: Virology DOI: 10.1016/0042-6822(91)90145-2 sha: doc_id: 300810 cord_uid: a1skdp67 file: cache/cord-324553-qd8249w3.json key: cord-324553-qd8249w3 authors: Cadegiani, F. A.; Wambier, C. G.; Goren, A. title: An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV Female Trial. date: 2020-10-06 journal: nan DOI: 10.1101/2020.10.05.20206870 sha: doc_id: 324553 cord_uid: qd8249w3 file: cache/cord-305365-50uojtet.json key: cord-305365-50uojtet authors: Easson, Will title: A review of rabbit and rodent production medicine date: 2001-07-31 journal: Seminars in Avian and Exotic Pet Medicine DOI: 10.1053/saep.2001.24252 sha: doc_id: 305365 cord_uid: 50uojtet file: cache/cord-326143-6ndqgxy8.json key: cord-326143-6ndqgxy8 authors: Wang, Qiang; Hu, Zhao title: Successful recovery of severe COVID-19 with cytokine storm treating with extracorporeal blood purification date: 2020-05-26 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.05.065 sha: doc_id: 326143 cord_uid: 6ndqgxy8 file: cache/cord-317347-by8albr9.json key: cord-317347-by8albr9 authors: van Ginkel, Frederik W.; Padgett, Justin; Martinez-Romero, Gisela; Miller, Matthew S.; Joiner, Kellye S.; Gulley, Stephen L. title: Age-dependent immune responses and immune protection after avian coronavirus vaccination date: 2015-05-28 journal: Vaccine DOI: 10.1016/j.vaccine.2015.04.026 sha: doc_id: 317347 cord_uid: by8albr9 file: cache/cord-330414-yh58ya39.json key: cord-330414-yh58ya39 authors: Agarwal, Deepak K.; Rivera, Marcelino E.; Nottingham, Charles U.; Large, Tim; Krambeck, Amy E. title: Catheter Removal on the Same Day of Holmium Laser Enucleation of the Prostate: Outcomes of a Pilot Study date: 2020-10-10 journal: Urology DOI: 10.1016/j.urology.2020.09.038 sha: doc_id: 330414 cord_uid: yh58ya39 file: cache/cord-318994-1xngjndu.json key: cord-318994-1xngjndu authors: Lier, Audun J.; Tuan, Jessica J.; Davis, Matthew W.; Paulson, Nathan; McManus, Dayna; Campbell, Sheldon; Peaper, David R.; Topal, Jeffrey E. title: Case Report: Disseminated Strongyloidiasis in a Patient with COVID-19 date: 2020-08-14 journal: Am J Trop Med Hyg DOI: 10.4269/ajtmh.20-0699 sha: doc_id: 318994 cord_uid: 1xngjndu file: cache/cord-324345-j43rpvwk.json key: cord-324345-j43rpvwk authors: Leong, Hoe Nam; Lim, Hong Huay title: SARS – My personal battle date: 2010-11-19 journal: Travel Med Infect Dis DOI: 10.1016/j.tmaid.2010.10.007 sha: doc_id: 324345 cord_uid: j43rpvwk file: cache/cord-331347-imexhlwn.json key: cord-331347-imexhlwn authors: Anzai, Asami; Kobayashi, Tetsuro; Linton, Natalie M.; Kinoshita, Ryo; Hayashi, Katsuma; Suzuki, Ayako; Yang, Yichi; Jung, Sung-mok; Miyama, Takeshi; Akhmetzhanov, Andrei R.; Nishiura, Hiroshi title: Assessing the Impact of Reduced Travel on Exportation Dynamics of Novel Coronavirus Infection (COVID-19) date: 2020-02-24 journal: J Clin Med DOI: 10.3390/jcm9020601 sha: doc_id: 331347 cord_uid: imexhlwn file: cache/cord-333522-zsdymkjd.json key: cord-333522-zsdymkjd authors: Gruse, Jeannine; Kanitz, Ellen; Weitzel, Joachim M.; Tuchscherer, Armin; Stefaniak, Tadeusz; Jawor, Paulina; Wolffram, Siegfried; Hammon, Harald M. title: Quercetin Feeding in Newborn Dairy Calves Cannot Compensate Colostrum Deprivation: Study on Metabolic, Antioxidative and Inflammatory Traits date: 2016-01-11 journal: PLoS One DOI: 10.1371/journal.pone.0146932 sha: doc_id: 333522 cord_uid: zsdymkjd file: cache/cord-335490-p63qlcnx.json key: cord-335490-p63qlcnx authors: Schenk, Thomas; Strahm, Brigitte; Kontny, Udo; Hufnagel, Markus; Neumann-Haefelin, Dieter; Falcone, Valeria title: Disseminated Bocavirus Infection after Stem Cell Transplant date: 2007-09-17 journal: Emerg Infect Dis DOI: 10.3201/eid1309.070318 sha: doc_id: 335490 cord_uid: p63qlcnx file: cache/cord-327045-hn8pmcto.json key: cord-327045-hn8pmcto authors: Li, Yao; Yao, Jiaying; Han, Chunyan; Yang, Jiaxin; Chaudhry, Maria Tabassum; Wang, Shengnan; Liu, Hongnan; Yin, Yulong title: Quercetin, Inflammation and Immunity date: 2016-03-15 journal: Nutrients DOI: 10.3390/nu8030167 sha: doc_id: 327045 cord_uid: hn8pmcto file: cache/cord-334667-0cah15lg.json key: cord-334667-0cah15lg authors: Arabi, Yaseen M.; Asiri, Ayed Y.; Assiri, Abdullah M.; Aziz Jokhdar, Hani A.; Alothman, Adel; Balkhy, Hanan H.; AlJohani, Sameera; Al Harbi, Shmeylan; Kojan, Suleiman; Al Jeraisy, Majed; Deeb, Ahmad M.; Memish, Ziad A.; Ghazal, Sameeh; Al Faraj, Sarah; Al-Hameed, Fahad; AlSaedi, Asim; Mandourah, Yasser; Al Mekhlafi, Ghaleb A.; Sherbeeni, Nisreen Murad; Elzein, Fatehi Elnour; Almotairi, Abdullah; Al Bshabshe, Ali; Kharaba, Ayman; Jose, Jesna; Al Harthy, Abdulrahman; Al Sulaiman, Mohammed; Mady, Ahmed; Fowler, Robert A.; Hayden, Frederick G.; Al-Dawood, Abdulaziz; Abdelzaher, Mohamed; Bajhmom, Wail; Hussein, Mohamed A. title: Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial date: 2020-01-03 journal: Trials DOI: 10.1186/s13063-019-3846-x sha: doc_id: 334667 cord_uid: 0cah15lg file: cache/cord-006849-vgjz74ts.json key: cord-006849-vgjz74ts authors: nan title: 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date: 2019-09-13 journal: Surg Endosc DOI: 10.1007/s00464-019-07109-x sha: doc_id: 6849 cord_uid: vgjz74ts file: cache/cord-337454-0h28a3az.json key: cord-337454-0h28a3az authors: Chartier, C.; Mallereau, Marie-Pierre; Naciri, Muriel title: Prophylaxis using paromomycin of natural cryptosporidial infection in neonatal kids date: 1996-01-31 journal: Preventive Veterinary Medicine DOI: 10.1016/0167-5877(95)00511-0 sha: doc_id: 337454 cord_uid: 0h28a3az file: cache/cord-319933-yp9ofhi8.json key: cord-319933-yp9ofhi8 authors: Ruiz, Sara I.; Zumbrun, Elizabeth E.; Nalca, Aysegul title: Chapter 38 Animal Models of Human Viral Diseases date: 2013-12-31 journal: Animal Models for the Study of Human Disease DOI: 10.1016/b978-0-12-415894-8.00038-5 sha: doc_id: 319933 cord_uid: yp9ofhi8 file: cache/cord-343789-6tq0kcfd.json key: cord-343789-6tq0kcfd authors: Al-Tawfiq, Jaffar A.; Momattin, Hisham; Dib, Jean; Memish, Ziad A. title: Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study date: 2014-01-06 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2013.12.003 sha: doc_id: 343789 cord_uid: 6tq0kcfd file: cache/cord-347716-ka2lm62r.json key: cord-347716-ka2lm62r authors: Usher, Craigan title: Existential Returns date: 2020-06-25 journal: J Am Acad Child Adolesc Psychiatry DOI: 10.1016/j.jaac.2020.05.002 sha: doc_id: 347716 cord_uid: ka2lm62r file: cache/cord-337129-6wt6wzxv.json key: cord-337129-6wt6wzxv authors: Navas de Solis, Cristobal; Foreman, Jonathan H. title: Transient diabetes mellitus in a neonatal Thoroughbred foal date: 2010-10-07 journal: J Vet Emerg Crit Care (San Antonio) DOI: 10.1111/j.1476-4431.2010.00588.x sha: doc_id: 337129 cord_uid: 6wt6wzxv file: cache/cord-347140-q8qis03p.json key: cord-347140-q8qis03p authors: Dietz, Thomas title: Earth Day: 50 Years of Continuity and Change in Environmentalism date: 2020-04-17 journal: nan DOI: 10.1016/j.oneear.2020.04.003 sha: doc_id: 347140 cord_uid: q8qis03p file: cache/cord-350024-whne0l19.json key: cord-350024-whne0l19 authors: Anderson, Victoria L.; Miskinis-Hilligoss, Dianne title: Choosing the Right Antibiotic in Ambulatory Care date: 2006-11-28 journal: J Nurse Pract DOI: 10.1016/j.nurpra.2006.09.009 sha: doc_id: 350024 cord_uid: whne0l19 file: cache/cord-336000-v88bq4bx.json key: cord-336000-v88bq4bx authors: Barco, Stefano; Bingisser, Roland; Colucci, Giuseppe; Frenk, André; Gerber, Bernhard; Held, Ulrike; Mach, Francois; Mazzolai, Lucia; Righini, Marc; Rosemann, Thomas; Sebastian, Tim; Spescha, Rebecca; Stortecky, Stefan; Windecker, Stephan; Kucher, Nils title: Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial date: 2020-09-09 journal: Trials DOI: 10.1186/s13063-020-04678-4 sha: doc_id: 336000 cord_uid: v88bq4bx file: cache/cord-343349-ftzjdvfj.json key: cord-343349-ftzjdvfj authors: Bhatt, P. N.; Jacoby, R. O. title: Experimental infection of adult axenic rats with Parker's Rat Coronavirus date: 1977 journal: Arch Virol DOI: 10.1007/bf01314779 sha: doc_id: 343349 cord_uid: ftzjdvfj file: cache/cord-349329-f0pbd968.json key: cord-349329-f0pbd968 authors: Bosteels, Cedric; Maes, Bastiaan; Van Damme, Karel; De Leeuw, Elisabeth; Declercq, Jozefien; Delporte, Anja; Demeyere, Bénédicte; Vermeersch, Stéfanie; Vuylsteke, Marnik; Willaert, Joren; Bollé, Laura; Vanbiervliet, Yuri; Decuypere, Jana; Libeer, Frederick; Vandecasteele, Stefaan; Peene, Isabelle; Lambrecht, Bart title: Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-05 journal: Trials DOI: 10.1186/s13063-020-04451-7 sha: doc_id: 349329 cord_uid: f0pbd968 file: cache/cord-346836-6jyv0q5e.json key: cord-346836-6jyv0q5e authors: Ikegami, Tetsuro; Makino, Shinji title: The Pathogenesis of Rift Valley Fever date: 2011-05-06 journal: Viruses DOI: 10.3390/v3050493 sha: doc_id: 346836 cord_uid: 6jyv0q5e file: cache/cord-335975-m6lkrehi.json key: cord-335975-m6lkrehi authors: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 journal: Ann Intensive Care DOI: 10.1186/s13613-017-0345-7 sha: doc_id: 335975 cord_uid: m6lkrehi file: cache/cord-341063-3rqnu5bu.json key: cord-341063-3rqnu5bu authors: nan title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 journal: Crit Care DOI: 10.1186/s13054-018-1973-5 sha: doc_id: 341063 cord_uid: 3rqnu5bu file: cache/cord-355038-o2hr5mox.json key: cord-355038-o2hr5mox authors: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 journal: Ann Intensive Care DOI: 10.1186/s13613-020-0623-7 sha: doc_id: 355038 cord_uid: o2hr5mox file: cache/cord-023095-4dannjjm.json key: cord-023095-4dannjjm authors: nan title: Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011 date: 2011-05-03 journal: J Vet Intern Med DOI: 10.1111/j.1939-1676.2011.0726.x sha: doc_id: 23095 cord_uid: 4dannjjm file: cache/cord-015021-pol2qm74.json key: cord-015021-pol2qm74 authors: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 journal: Intensive Care Med DOI: 10.1007/bf02258437 sha: doc_id: 15021 cord_uid: pol2qm74 file: cache/cord-005814-ak5pq312.json key: cord-005814-ak5pq312 authors: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 journal: Intensive Care Med DOI: 10.1007/bf02426401 sha: doc_id: 5814 cord_uid: ak5pq312 file: cache/cord-005460-ezrn8cva.json key: cord-005460-ezrn8cva authors: nan title: Physicians – Poster Session date: 2017-07-28 journal: Bone Marrow Transplant DOI: 10.1038/bmt.2017.134 sha: doc_id: 5460 cord_uid: ezrn8cva file: cache/cord-005453-4057qib7.json key: cord-005453-4057qib7 authors: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 journal: Bone Marrow Transplant DOI: 10.1038/s41409-019-0559-4 sha: doc_id: 5453 cord_uid: 4057qib7 file: cache/cord-010119-t1x9gknd.json key: cord-010119-t1x9gknd authors: nan title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date: 2017-09-04 journal: Transfusion DOI: 10.1111/trf.14286 sha: doc_id: 10119 cord_uid: t1x9gknd Reading metadata file and updating bibliogrpahics === updating bibliographic database Building study carrel named keyword-day-cord === file2bib.sh === id: cord-280242-2w2kl0uf author: Kaya, Yildiz title: Transient cortical blindness in COVID-19 pneumonia; a PRES-like syndrome: A case report date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-280242-2w2kl0uf.txt cache: ./cache/cord-280242-2w2kl0uf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-280242-2w2kl0uf.txt' === file2bib.sh === id: cord-023100-0pqnsiid author: nan title: Abstract date: 2008-04-10 pages: extension: .txt txt: ./txt/cord-023100-0pqnsiid.txt cache: ./cache/cord-023100-0pqnsiid.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-023100-0pqnsiid.txt' === file2bib.sh === id: cord-224211-6lsvjfqb author: Schaback, Robert title: Modelling Recovered Cases and Death Probabilities for the COVID-19 Outbreak date: 2020-03-26 pages: extension: .txt txt: ./txt/cord-224211-6lsvjfqb.txt cache: ./cache/cord-224211-6lsvjfqb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-224211-6lsvjfqb.txt' === file2bib.sh === id: cord-256015-tt58n0jk author: Zhu, Juanjuan title: Clinical characteristics and therapeutic procedure for a critical case of novel coronavirus pneumonia treated with glucocorticoids and non-invasive ventilator treatment date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-256015-tt58n0jk.txt cache: ./cache/cord-256015-tt58n0jk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-256015-tt58n0jk.txt' === file2bib.sh === id: cord-033791-q0wizf2n author: Kavirayani, Akhila title: The Lazarus effect of very high-dose intravenous anakinra in severe non-familial CNS-HLH date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-033791-q0wizf2n.txt cache: ./cache/cord-033791-q0wizf2n.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-033791-q0wizf2n.txt' === file2bib.sh === id: cord-032240-xswtx940 author: Sauer, François title: Pericardial effusion in patients with COVID-19: case series date: 2020-09-09 pages: extension: .txt txt: ./txt/cord-032240-xswtx940.txt cache: ./cache/cord-032240-xswtx940.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-032240-xswtx940.txt' === file2bib.sh === id: cord-000097-vueo83vk author: Beretta, Chiara title: Prolonged extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome in a child affected by rituximab-resistant autoimmune hemolytic anemia: a case report date: 2009-04-01 pages: extension: .txt txt: ./txt/cord-000097-vueo83vk.txt cache: ./cache/cord-000097-vueo83vk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-000097-vueo83vk.txt' === file2bib.sh === id: cord-271298-7vk3wgw1 author: Sato, Tomoi title: Feeding behavior during sialodacryoadenitis viral infection in rats date: 2001-04-30 pages: extension: .txt txt: ./txt/cord-271298-7vk3wgw1.txt cache: ./cache/cord-271298-7vk3wgw1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-271298-7vk3wgw1.txt' === file2bib.sh === id: cord-266183-uzuda3ir author: Renieris, Georgios title: Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Corona virus date: 2020-05-18 pages: extension: .txt txt: ./txt/cord-266183-uzuda3ir.txt cache: ./cache/cord-266183-uzuda3ir.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-266183-uzuda3ir.txt' === file2bib.sh === id: cord-163587-zjnr7vwm author: Altmejd, Adam title: Nowcasting Covid-19 statistics reported withdelay: a case-study of Sweden date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-163587-zjnr7vwm.txt cache: ./cache/cord-163587-zjnr7vwm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-163587-zjnr7vwm.txt' === file2bib.sh === id: cord-292970-32mql9nq author: Camdessanche, Jean-Philippe title: COVID-19 may induce Guillain-Barré syndrome date: 2020-04-15 pages: extension: .txt txt: ./txt/cord-292970-32mql9nq.txt cache: ./cache/cord-292970-32mql9nq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-292970-32mql9nq.txt' === file2bib.sh === id: cord-006344-de4dhv4b author: Seitsonen, E. title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection date: 2006-03-21 pages: extension: .txt txt: ./txt/cord-006344-de4dhv4b.txt cache: ./cache/cord-006344-de4dhv4b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006344-de4dhv4b.txt' === file2bib.sh === id: cord-010130-28bt3x25 author: Crocchiolo, R. title: Infections after T‐replete haploidentical transplantation and high‐dose cyclophosphamide as graft‐versus‐host disease prophylaxis date: 2015-03-26 pages: extension: .txt txt: ./txt/cord-010130-28bt3x25.txt cache: ./cache/cord-010130-28bt3x25.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010130-28bt3x25.txt' === file2bib.sh === id: cord-271180-cnrs0zpg author: Rizvi, Saniya title: Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? A case report. date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-271180-cnrs0zpg.txt cache: ./cache/cord-271180-cnrs0zpg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-271180-cnrs0zpg.txt' === file2bib.sh === id: cord-295086-tc3re52f author: Lu, Guoguang title: Dynamic changes in routine blood parameters of a severe COVID-19 case date: 2020-05-13 pages: extension: .txt txt: ./txt/cord-295086-tc3re52f.txt cache: ./cache/cord-295086-tc3re52f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295086-tc3re52f.txt' === file2bib.sh === id: cord-000059-5hwqdnx1 author: Tokars, Jerome I. title: Enhancing Time-Series Detection Algorithms for Automated Biosurveillance date: 2009-04-17 pages: extension: .txt txt: ./txt/cord-000059-5hwqdnx1.txt cache: ./cache/cord-000059-5hwqdnx1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000059-5hwqdnx1.txt' === file2bib.sh === id: cord-007456-acbo4zs2 author: Thomas, L.H. title: Growth of Mycoplasma bovis in organ cultures of bovine foetal trachea and comparison with Mycoplasma dispar date: 2002-11-13 pages: extension: .txt txt: ./txt/cord-007456-acbo4zs2.txt cache: ./cache/cord-007456-acbo4zs2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-007456-acbo4zs2.txt' === file2bib.sh === id: cord-283257-rh3bxvv7 author: Andrejčáková, Zuzana title: Synbiotics suppress the release of lactate dehydrogenase, promote non‐specific immunity and integrity of jejunum mucosa in piglets date: 2015-12-21 pages: extension: .txt txt: ./txt/cord-283257-rh3bxvv7.txt cache: ./cache/cord-283257-rh3bxvv7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-283257-rh3bxvv7.txt' === file2bib.sh === id: cord-007288-lzxi6q1p author: Pazin, George J. title: Leukocyte Interferon for Treating First Episodes of Genital Herpes in Women date: 1987-12-17 pages: extension: .txt txt: ./txt/cord-007288-lzxi6q1p.txt cache: ./cache/cord-007288-lzxi6q1p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-007288-lzxi6q1p.txt' === file2bib.sh === id: cord-027811-vk3qnumx author: Freedberg, Daniel E. title: Impact of Fiber-Based Enteral Nutrition on the Gut Microbiome of ICU Patients Receiving Broad-Spectrum Antibiotics: A Randomized Pilot Trial date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-027811-vk3qnumx.txt cache: ./cache/cord-027811-vk3qnumx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-027811-vk3qnumx.txt' === file2bib.sh === id: cord-002659-566uoozj author: Fujimoto, Yousuke title: Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection date: 2017-08-22 pages: extension: .txt txt: ./txt/cord-002659-566uoozj.txt cache: ./cache/cord-002659-566uoozj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-002659-566uoozj.txt' === file2bib.sh === id: cord-265891-jmpterrj author: Eilersen, Andreas title: Cost–benefit of limited isolation and testing in COVID-19 mitigation date: 2020-10-29 pages: extension: .txt txt: ./txt/cord-265891-jmpterrj.txt cache: ./cache/cord-265891-jmpterrj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-265891-jmpterrj.txt' === file2bib.sh === id: cord-274497-tqceazdp author: N. Nuñez, Luis Fabian title: Molecular Characterization and Pathogenicity of Chicken Parvovirus (ChPV) in Specific Pathogen-Free Chicks Infected Experimentally date: 2020-07-25 pages: extension: .txt txt: ./txt/cord-274497-tqceazdp.txt cache: ./cache/cord-274497-tqceazdp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-274497-tqceazdp.txt' === file2bib.sh === id: cord-304562-5xh4p786 author: Tanabe, Naoya title: Dupilumab maintenance therapy in an asthmatic patient with coronavirus disease 2019 pneumonia date: 2020-11-07 pages: extension: .txt txt: ./txt/cord-304562-5xh4p786.txt cache: ./cache/cord-304562-5xh4p786.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-304562-5xh4p786.txt' === file2bib.sh === id: cord-287182-f0q8gfzc author: Liao, Ji‐ping title: Severe pneumonia caused by adenovirus 7 in pregnant woman: Case report and review of the literature date: 2016-06-21 pages: extension: .txt txt: ./txt/cord-287182-f0q8gfzc.txt cache: ./cache/cord-287182-f0q8gfzc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-287182-f0q8gfzc.txt' === file2bib.sh === id: cord-034257-kl2ccmz5 author: de Jonge, Jeroen C. title: PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment date: 2020-10-26 pages: extension: .txt txt: ./txt/cord-034257-kl2ccmz5.txt cache: ./cache/cord-034257-kl2ccmz5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-034257-kl2ccmz5.txt' === file2bib.sh === id: cord-003533-8m0vyxq8 author: Jayathilaka, P. G. N. S. title: An outbreak of leptospirosis with predominant cardiac involvement: a case series date: 2019-03-18 pages: extension: .txt txt: ./txt/cord-003533-8m0vyxq8.txt cache: ./cache/cord-003533-8m0vyxq8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003533-8m0vyxq8.txt' === file2bib.sh === id: cord-001192-zbogocki author: van Meer, Maurits PA title: Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report date: 2014-01-30 pages: extension: .txt txt: ./txt/cord-001192-zbogocki.txt cache: ./cache/cord-001192-zbogocki.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-001192-zbogocki.txt' === file2bib.sh === id: cord-268081-ytx6sf3x author: Guionie, Olivier title: An experimental study of the survival of turkey coronavirus at room temperature and +4°C date: 2013-04-22 pages: extension: .txt txt: ./txt/cord-268081-ytx6sf3x.txt cache: ./cache/cord-268081-ytx6sf3x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268081-ytx6sf3x.txt' === file2bib.sh === id: cord-009772-pzxvicee author: GRÜNBERG, K. title: Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo date: 2006-04-27 pages: extension: .txt txt: ./txt/cord-009772-pzxvicee.txt cache: ./cache/cord-009772-pzxvicee.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009772-pzxvicee.txt' === file2bib.sh === id: cord-274860-7ec2jcoq author: Salazar, Eric title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG date: 2020-11-04 pages: extension: .txt txt: ./txt/cord-274860-7ec2jcoq.txt cache: ./cache/cord-274860-7ec2jcoq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274860-7ec2jcoq.txt' === file2bib.sh === id: cord-027259-f4sgobcz author: Metsker, Oleg title: Stroke ICU Patient Mortality Day Prediction date: 2020-05-23 pages: extension: .txt txt: ./txt/cord-027259-f4sgobcz.txt cache: ./cache/cord-027259-f4sgobcz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-027259-f4sgobcz.txt' === file2bib.sh === id: cord-000705-w52dc97h author: Ríos, Fernando G title: Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic date: 2011-08-17 pages: extension: .txt txt: ./txt/cord-000705-w52dc97h.txt cache: ./cache/cord-000705-w52dc97h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-000705-w52dc97h.txt' === file2bib.sh === id: cord-001262-8s7g2wvd author: Zheng, Guoping title: Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study date: 2014-04-04 pages: extension: .txt txt: ./txt/cord-001262-8s7g2wvd.txt cache: ./cache/cord-001262-8s7g2wvd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001262-8s7g2wvd.txt' === file2bib.sh === id: cord-266571-qbskh1uu author: de Arriba, M.L title: Lymphoproliferative responses and protection in conventional piglets inoculated orally with virulent or attenuated porcine epidemic diarrhoea virus date: 2002-06-04 pages: extension: .txt txt: ./txt/cord-266571-qbskh1uu.txt cache: ./cache/cord-266571-qbskh1uu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266571-qbskh1uu.txt' === file2bib.sh === id: cord-268341-103xf3dw author: Parra, Beatriz title: Kinetics of Cytokine mRNA Expression in the Central Nervous System Following Lethal and Nonlethal Coronavirus-Induced Acute Encephalomyelitis date: 1997-07-07 pages: extension: .txt txt: ./txt/cord-268341-103xf3dw.txt cache: ./cache/cord-268341-103xf3dw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-268341-103xf3dw.txt' === file2bib.sh === id: cord-288051-wp8v2mc5 author: Sánchez-González, Álvaro title: What Should Be Known by a Urologist About the Medical Management of COVID-19’s Patients? date: 2020-09-01 pages: extension: .txt txt: ./txt/cord-288051-wp8v2mc5.txt cache: ./cache/cord-288051-wp8v2mc5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-288051-wp8v2mc5.txt' === file2bib.sh === id: cord-032806-o6p861ms author: Fenin, Audrey title: Very low birth weight infants receive full enteral nutrition within 2 postnatal weeks date: 2020-09-29 pages: extension: .txt txt: ./txt/cord-032806-o6p861ms.txt cache: ./cache/cord-032806-o6p861ms.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-032806-o6p861ms.txt' === file2bib.sh === id: cord-258696-01wj76es author: Decaro, Nicola title: Experimental infection of dogs with a novel strain of canine coronavirus causing systemic disease and lymphopenia date: 2008-04-30 pages: extension: .txt txt: ./txt/cord-258696-01wj76es.txt cache: ./cache/cord-258696-01wj76es.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-258696-01wj76es.txt' === file2bib.sh === id: cord-280821-kc0ut4oy author: Venturini, Elisabetta title: Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease date: 2020-09-24 pages: extension: .txt txt: ./txt/cord-280821-kc0ut4oy.txt cache: ./cache/cord-280821-kc0ut4oy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-280821-kc0ut4oy.txt' === file2bib.sh === id: cord-285812-l7dpv6nx author: O’TOOLE, D. title: Pathogenicity of experimental infection with ‘pneumotropic’ porcine coronavirus date: 1989-07-31 pages: extension: .txt txt: ./txt/cord-285812-l7dpv6nx.txt cache: ./cache/cord-285812-l7dpv6nx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-285812-l7dpv6nx.txt' === file2bib.sh === id: cord-002945-29nj4f05 author: Ambrose, Rebecca K. title: In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c) date: 2018-01-19 pages: extension: .txt txt: ./txt/cord-002945-29nj4f05.txt cache: ./cache/cord-002945-29nj4f05.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-002945-29nj4f05.txt' === file2bib.sh === id: cord-266156-xmf4emln author: Miller, Tyler E. title: Clinical sensitivity and interpretation of PCR and serological COVID‐19 diagnostics for patients presenting to the hospital date: 2020-08-28 pages: extension: .txt txt: ./txt/cord-266156-xmf4emln.txt cache: ./cache/cord-266156-xmf4emln.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266156-xmf4emln.txt' === file2bib.sh === id: cord-257654-8u9m1k5q author: Tschöpe, Carsten title: Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis date: 2020-07-14 pages: extension: .txt txt: ./txt/cord-257654-8u9m1k5q.txt cache: ./cache/cord-257654-8u9m1k5q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-257654-8u9m1k5q.txt' === file2bib.sh === id: cord-002957-gw2cow0d author: Gray, Darren W. title: DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles date: 2018-04-05 pages: extension: .txt txt: ./txt/cord-002957-gw2cow0d.txt cache: ./cache/cord-002957-gw2cow0d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-002957-gw2cow0d.txt' === file2bib.sh === id: cord-275427-00bwhaga author: Aydogdu, Ugur title: The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis date: 2019-11-30 pages: extension: .txt txt: ./txt/cord-275427-00bwhaga.txt cache: ./cache/cord-275427-00bwhaga.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-275427-00bwhaga.txt' === file2bib.sh === id: cord-306705-adshd3jj author: Lenander-Lumikari, Marianne title: Effects of the common cold and intranasal fluticasone propionate treatment on mucosal host defense assessed by human saliva()()() date: 2005-11-04 pages: extension: .txt txt: ./txt/cord-306705-adshd3jj.txt cache: ./cache/cord-306705-adshd3jj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-306705-adshd3jj.txt' === file2bib.sh === id: cord-276338-wpo1eyeg author: Hesse, Amke title: In toxic demyelination oligodendroglial cell death occurs early and is FAS independent date: 2009-10-22 pages: extension: .txt txt: ./txt/cord-276338-wpo1eyeg.txt cache: ./cache/cord-276338-wpo1eyeg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-276338-wpo1eyeg.txt' === file2bib.sh === id: cord-282158-08u3x1z4 author: Yang, William H. title: Long-term immunogenicity of an AS03-adjuvanted influenza A(H1N1)pdm09 vaccine in young and elderly adults: An observer-blind, randomized trial() date: 2013-09-13 pages: extension: .txt txt: ./txt/cord-282158-08u3x1z4.txt cache: ./cache/cord-282158-08u3x1z4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-282158-08u3x1z4.txt' === file2bib.sh === id: cord-287520-51kmd2ds author: Carneiro, Arie title: Impact of the COVID-19 Pandemic on the Urologist’s clinical practice in Brazil: a management guideline proposal for low- and middle-income countries during the crisis period date: 2020-05-20 pages: extension: .txt txt: ./txt/cord-287520-51kmd2ds.txt cache: ./cache/cord-287520-51kmd2ds.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-287520-51kmd2ds.txt' === file2bib.sh === id: cord-295703-no45mgyd author: ALTAY, O. title: Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 date: 2020-10-05 pages: extension: .txt txt: ./txt/cord-295703-no45mgyd.txt cache: ./cache/cord-295703-no45mgyd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295703-no45mgyd.txt' === file2bib.sh === id: cord-007064-nepgttxf author: Chemaly, Roy F title: A Phase II, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients date: 2019-12-03 pages: extension: .txt txt: ./txt/cord-007064-nepgttxf.txt cache: ./cache/cord-007064-nepgttxf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-007064-nepgttxf.txt' === file2bib.sh === id: cord-282268-f7mbdfr6 author: Cartenì, Armando title: How mobility habits influenced the spread of the COVID-19 pandemic: Results from the Italian case study date: 2020-06-24 pages: extension: .txt txt: ./txt/cord-282268-f7mbdfr6.txt cache: ./cache/cord-282268-f7mbdfr6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-282268-f7mbdfr6.txt' === file2bib.sh === id: cord-300570-xes201g7 author: Patwardhan, J. title: PREDICTIONS FOR EUROPE FOR THE COVID-19 PANDEMICAFTER LOCKDOWN WAS LIFTED USING AN SIR MODEL date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-300570-xes201g7.txt cache: ./cache/cord-300570-xes201g7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300570-xes201g7.txt' === file2bib.sh === id: cord-295633-vkjcheaz author: Hao, Xin‐yan title: The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose‐only exposure device date: 2019-10-30 pages: extension: .txt txt: ./txt/cord-295633-vkjcheaz.txt cache: ./cache/cord-295633-vkjcheaz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-295633-vkjcheaz.txt' === file2bib.sh === id: cord-285096-g9y3au1a author: Mitchell, Judy A. title: Tropism and pathological findings associated with canine respiratory coronavirus (CRCoV) date: 2013-03-23 pages: extension: .txt txt: ./txt/cord-285096-g9y3au1a.txt cache: ./cache/cord-285096-g9y3au1a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-285096-g9y3au1a.txt' === file2bib.sh === id: cord-275889-4qwp3um1 author: Guarnieri, M. title: Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats date: 2017-04-09 pages: extension: .txt txt: ./txt/cord-275889-4qwp3um1.txt cache: ./cache/cord-275889-4qwp3um1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-275889-4qwp3um1.txt' === file2bib.sh === id: cord-310249-cvv77f10 author: Yule, Terecita D. title: Canine parvovirus vaccine elicits protection from the inflammatory and clinical consequences of the disease date: 1997-05-31 pages: extension: .txt txt: ./txt/cord-310249-cvv77f10.txt cache: ./cache/cord-310249-cvv77f10.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-310249-cvv77f10.txt' === file2bib.sh === id: cord-291315-y40s45iv author: Logunov, Denis Y title: Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-291315-y40s45iv.txt cache: ./cache/cord-291315-y40s45iv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291315-y40s45iv.txt' === file2bib.sh === id: cord-309588-kw4d32dt author: Chan, Michael H.M. title: Steroid-induced osteonecrosis in severe acute respiratory syndrome: a retrospective analysis of biochemical markers of bone metabolism and corticosteroid therapy date: 2006-06-30 pages: extension: .txt txt: ./txt/cord-309588-kw4d32dt.txt cache: ./cache/cord-309588-kw4d32dt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-309588-kw4d32dt.txt' === file2bib.sh === id: cord-018239-n7axd9bq author: Rusoke-Dierich, Olaf title: Travel Medicine date: 2018-03-13 pages: extension: .txt txt: ./txt/cord-018239-n7axd9bq.txt cache: ./cache/cord-018239-n7axd9bq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-018239-n7axd9bq.txt' === file2bib.sh === id: cord-007178-h0ordzm9 author: Felts, Paul A. title: Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide date: 2005-05-04 pages: extension: .txt txt: ./txt/cord-007178-h0ordzm9.txt cache: ./cache/cord-007178-h0ordzm9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-007178-h0ordzm9.txt' === file2bib.sh === id: cord-277077-kwaiorp8 author: Tița, Ovidiu title: Use of Yoghurt Enhanced with Volatile Plant Oils Encapsulated in Sodium Alginate to Increase the Human Body’s Immunity in the Present Fight Against Stress date: 2020-10-19 pages: extension: .txt txt: ./txt/cord-277077-kwaiorp8.txt cache: ./cache/cord-277077-kwaiorp8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-277077-kwaiorp8.txt' === file2bib.sh === id: cord-031315-p7jb4gf2 author: Kong, Qing title: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-031315-p7jb4gf2.txt cache: ./cache/cord-031315-p7jb4gf2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-031315-p7jb4gf2.txt' === file2bib.sh === id: cord-295367-xhdki8jn author: McNally, D. title: Rapid relief of acute sore throat with AMC/DCBA throat lozenges: randomised controlled trial date: 2009-10-22 pages: extension: .txt txt: ./txt/cord-295367-xhdki8jn.txt cache: ./cache/cord-295367-xhdki8jn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295367-xhdki8jn.txt' === file2bib.sh === id: cord-326143-6ndqgxy8 author: Wang, Qiang title: Successful recovery of severe COVID-19 with cytokine storm treating with extracorporeal blood purification date: 2020-05-26 pages: extension: .txt txt: ./txt/cord-326143-6ndqgxy8.txt cache: ./cache/cord-326143-6ndqgxy8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-326143-6ndqgxy8.txt' === file2bib.sh === id: cord-278224-sq7tokbx author: Protopopova, Alexandra title: Behavioral predictors of subsequent respiratory illness signs in dogs admitted to an animal shelter date: 2019-10-23 pages: extension: .txt txt: ./txt/cord-278224-sq7tokbx.txt cache: ./cache/cord-278224-sq7tokbx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-278224-sq7tokbx.txt' === file2bib.sh === id: cord-301947-b6nwaost author: Millán-Oñate, José title: Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-301947-b6nwaost.txt cache: ./cache/cord-301947-b6nwaost.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-301947-b6nwaost.txt' === file2bib.sh === id: cord-330414-yh58ya39 author: Agarwal, Deepak K. title: Catheter Removal on the Same Day of Holmium Laser Enucleation of the Prostate: Outcomes of a Pilot Study date: 2020-10-10 pages: extension: .txt txt: ./txt/cord-330414-yh58ya39.txt cache: ./cache/cord-330414-yh58ya39.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-330414-yh58ya39.txt' === file2bib.sh === id: cord-318994-1xngjndu author: Lier, Audun J. title: Case Report: Disseminated Strongyloidiasis in a Patient with COVID-19 date: 2020-08-14 pages: extension: .txt txt: ./txt/cord-318994-1xngjndu.txt cache: ./cache/cord-318994-1xngjndu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-318994-1xngjndu.txt' === file2bib.sh === id: cord-337454-0h28a3az author: Chartier, C. title: Prophylaxis using paromomycin of natural cryptosporidial infection in neonatal kids date: 1996-01-31 pages: extension: .txt txt: ./txt/cord-337454-0h28a3az.txt cache: ./cache/cord-337454-0h28a3az.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337454-0h28a3az.txt' === file2bib.sh === id: cord-314235-08z2jyzd author: Matzinger, P. title: Strong impact of closing schools, closing bars and wearing masks during the Covid-19 pandemic: results from a simple and revealing analysis date: 2020-09-28 pages: extension: .txt txt: ./txt/cord-314235-08z2jyzd.txt cache: ./cache/cord-314235-08z2jyzd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-314235-08z2jyzd.txt' === file2bib.sh === id: cord-335490-p63qlcnx author: Schenk, Thomas title: Disseminated Bocavirus Infection after Stem Cell Transplant date: 2007-09-17 pages: extension: .txt txt: ./txt/cord-335490-p63qlcnx.txt cache: ./cache/cord-335490-p63qlcnx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-335490-p63qlcnx.txt' === file2bib.sh === id: cord-299343-gsrgf4dd author: Wilson, A. M. title: Quantifying SARS-CoV-2 infection risk within the Apple/Google exposure notification framework to inform quarantine recommendations date: 2020-07-19 pages: extension: .txt txt: ./txt/cord-299343-gsrgf4dd.txt cache: ./cache/cord-299343-gsrgf4dd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-299343-gsrgf4dd.txt' === file2bib.sh === id: cord-324345-j43rpvwk author: Leong, Hoe Nam title: SARS – My personal battle date: 2010-11-19 pages: extension: .txt txt: ./txt/cord-324345-j43rpvwk.txt cache: ./cache/cord-324345-j43rpvwk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324345-j43rpvwk.txt' === file2bib.sh === id: cord-347716-ka2lm62r author: Usher, Craigan title: Existential Returns date: 2020-06-25 pages: extension: .txt txt: ./txt/cord-347716-ka2lm62r.txt cache: ./cache/cord-347716-ka2lm62r.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-347716-ka2lm62r.txt' === file2bib.sh === id: cord-343349-ftzjdvfj author: Bhatt, P. N. title: Experimental infection of adult axenic rats with Parker's Rat Coronavirus date: 1977 pages: extension: .txt txt: ./txt/cord-343349-ftzjdvfj.txt cache: ./cache/cord-343349-ftzjdvfj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-343349-ftzjdvfj.txt' === file2bib.sh === id: cord-033453-557obi3r author: Bretscher, Lorenzo title: COVID-19 and the Cross-Section of Equity Returns: Impact and Transmission date: 2020-09-24 pages: extension: .txt txt: ./txt/cord-033453-557obi3r.txt cache: ./cache/cord-033453-557obi3r.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-033453-557obi3r.txt' === file2bib.sh === id: cord-347140-q8qis03p author: Dietz, Thomas title: Earth Day: 50 Years of Continuity and Change in Environmentalism date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-347140-q8qis03p.txt cache: ./cache/cord-347140-q8qis03p.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-347140-q8qis03p.txt' === file2bib.sh === id: cord-343789-6tq0kcfd author: Al-Tawfiq, Jaffar A. title: Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study date: 2014-01-06 pages: extension: .txt txt: ./txt/cord-343789-6tq0kcfd.txt cache: ./cache/cord-343789-6tq0kcfd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-343789-6tq0kcfd.txt' === file2bib.sh === id: cord-300810-a1skdp67 author: Lafay, F. title: Spread of the CVS strain of rabies virus and of the avirulent mutant AvO1 along the olfactory pathways of the mouse after intranasal inoculation date: 1991-07-31 pages: extension: .txt txt: ./txt/cord-300810-a1skdp67.txt cache: ./cache/cord-300810-a1skdp67.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-300810-a1skdp67.txt' === file2bib.sh === id: cord-334667-0cah15lg author: Arabi, Yaseen M. title: Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial date: 2020-01-03 pages: extension: .txt txt: ./txt/cord-334667-0cah15lg.txt cache: ./cache/cord-334667-0cah15lg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-334667-0cah15lg.txt' === file2bib.sh === id: cord-324553-qd8249w3 author: Cadegiani, F. A. title: An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV Female Trial. date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-324553-qd8249w3.txt cache: ./cache/cord-324553-qd8249w3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324553-qd8249w3.txt' === file2bib.sh === id: cord-305365-50uojtet author: Easson, Will title: A review of rabbit and rodent production medicine date: 2001-07-31 pages: extension: .txt txt: ./txt/cord-305365-50uojtet.txt cache: ./cache/cord-305365-50uojtet.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-305365-50uojtet.txt' === file2bib.sh === id: cord-337129-6wt6wzxv author: Navas de Solis, Cristobal title: Transient diabetes mellitus in a neonatal Thoroughbred foal date: 2010-10-07 pages: extension: .txt txt: ./txt/cord-337129-6wt6wzxv.txt cache: ./cache/cord-337129-6wt6wzxv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-337129-6wt6wzxv.txt' === file2bib.sh === id: cord-331347-imexhlwn author: Anzai, Asami title: Assessing the Impact of Reduced Travel on Exportation Dynamics of Novel Coronavirus Infection (COVID-19) date: 2020-02-24 pages: extension: .txt txt: ./txt/cord-331347-imexhlwn.txt cache: ./cache/cord-331347-imexhlwn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-331347-imexhlwn.txt' === file2bib.sh === id: cord-030957-45tc5ksf author: Schaap, Andrew title: The politics of precarity date: 2020-08-28 pages: extension: .txt txt: ./txt/cord-030957-45tc5ksf.txt cache: ./cache/cord-030957-45tc5ksf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-030957-45tc5ksf.txt' === file2bib.sh === id: cord-303878-v2n9jeeb author: Stiles, Jonathan title: Working at home and elsewhere: daily work location, telework, and travel among United States knowledge workers date: 2020-09-05 pages: extension: .txt txt: ./txt/cord-303878-v2n9jeeb.txt cache: ./cache/cord-303878-v2n9jeeb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-303878-v2n9jeeb.txt' === file2bib.sh === id: cord-317347-by8albr9 author: van Ginkel, Frederik W. title: Age-dependent immune responses and immune protection after avian coronavirus vaccination date: 2015-05-28 pages: extension: .txt txt: ./txt/cord-317347-by8albr9.txt cache: ./cache/cord-317347-by8albr9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-317347-by8albr9.txt' === file2bib.sh === id: cord-350024-whne0l19 author: Anderson, Victoria L. title: Choosing the Right Antibiotic in Ambulatory Care date: 2006-11-28 pages: extension: .txt txt: ./txt/cord-350024-whne0l19.txt cache: ./cache/cord-350024-whne0l19.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-350024-whne0l19.txt' === file2bib.sh === id: cord-327045-hn8pmcto author: Li, Yao title: Quercetin, Inflammation and Immunity date: 2016-03-15 pages: extension: .txt txt: ./txt/cord-327045-hn8pmcto.txt cache: ./cache/cord-327045-hn8pmcto.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-327045-hn8pmcto.txt' === file2bib.sh === id: cord-333522-zsdymkjd author: Gruse, Jeannine title: Quercetin Feeding in Newborn Dairy Calves Cannot Compensate Colostrum Deprivation: Study on Metabolic, Antioxidative and Inflammatory Traits date: 2016-01-11 pages: extension: .txt txt: ./txt/cord-333522-zsdymkjd.txt cache: ./cache/cord-333522-zsdymkjd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-333522-zsdymkjd.txt' === file2bib.sh === id: cord-018110-mcw4v13c author: Arnold, Andreas title: Inner Ear date: 2010 pages: extension: .txt txt: ./txt/cord-018110-mcw4v13c.txt cache: ./cache/cord-018110-mcw4v13c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-018110-mcw4v13c.txt' === file2bib.sh === id: cord-346836-6jyv0q5e author: Ikegami, Tetsuro title: The Pathogenesis of Rift Valley Fever date: 2011-05-06 pages: extension: .txt txt: ./txt/cord-346836-6jyv0q5e.txt cache: ./cache/cord-346836-6jyv0q5e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-346836-6jyv0q5e.txt' === file2bib.sh === id: cord-349329-f0pbd968 author: Bosteels, Cedric title: Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-349329-f0pbd968.txt cache: ./cache/cord-349329-f0pbd968.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-349329-f0pbd968.txt' === file2bib.sh === id: cord-029112-u507i0t0 author: Smith, Keisha title: A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-029112-u507i0t0.txt cache: ./cache/cord-029112-u507i0t0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-029112-u507i0t0.txt' === file2bib.sh === id: cord-015389-vwgai4k9 author: nan title: Publication only date: 2009-03-25 pages: extension: .txt txt: ./txt/cord-015389-vwgai4k9.txt cache: ./cache/cord-015389-vwgai4k9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-015389-vwgai4k9.txt' === file2bib.sh === id: cord-015090-n6f4xupw author: nan title: PS 339-563 date: 2005-09-10 pages: extension: .txt txt: ./txt/cord-015090-n6f4xupw.txt cache: ./cache/cord-015090-n6f4xupw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-015090-n6f4xupw.txt' === file2bib.sh === id: cord-336000-v88bq4bx author: Barco, Stefano title: Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial date: 2020-09-09 pages: extension: .txt txt: ./txt/cord-336000-v88bq4bx.txt cache: ./cache/cord-336000-v88bq4bx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-336000-v88bq4bx.txt' === file2bib.sh === id: cord-006856-b1w25ob5 author: nan title: 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date: 2005 pages: extension: .txt txt: ./txt/cord-006856-b1w25ob5.txt cache: ./cache/cord-006856-b1w25ob5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006856-b1w25ob5.txt' === file2bib.sh === id: cord-319933-yp9ofhi8 author: Ruiz, Sara I. title: Chapter 38 Animal Models of Human Viral Diseases date: 2013-12-31 pages: extension: .txt txt: ./txt/cord-319933-yp9ofhi8.txt cache: ./cache/cord-319933-yp9ofhi8.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-319933-yp9ofhi8.txt' === file2bib.sh === id: cord-006444-eq56zhtd author: nan title: Abstracts of oral presentations and posters date: 1993 pages: extension: .txt txt: ./txt/cord-006444-eq56zhtd.txt cache: ./cache/cord-006444-eq56zhtd.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006444-eq56zhtd.txt' === file2bib.sh === id: cord-006391-esnsa4u5 author: nan title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 pages: extension: .txt txt: ./txt/cord-006391-esnsa4u5.txt cache: ./cache/cord-006391-esnsa4u5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-006391-esnsa4u5.txt' === file2bib.sh === id: cord-021453-vf8xbaug author: Dysko, Robert C. title: Biology and Diseases of Dogs date: 2007-09-02 pages: extension: .txt txt: ./txt/cord-021453-vf8xbaug.txt cache: ./cache/cord-021453-vf8xbaug.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-021453-vf8xbaug.txt' === file2bib.sh === id: cord-275828-c6d6nk7x author: Mikasa, Keiichi title: JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date: 2016-07-31 pages: extension: .txt txt: ./txt/cord-275828-c6d6nk7x.txt cache: ./cache/cord-275828-c6d6nk7x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-275828-c6d6nk7x.txt' === file2bib.sh === id: cord-022659-chwk2bs4 author: nan title: Abstracts: Poster session date: 2004-10-08 pages: extension: .txt txt: ./txt/cord-022659-chwk2bs4.txt cache: ./cache/cord-022659-chwk2bs4.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-022659-chwk2bs4.txt' === file2bib.sh === id: cord-014976-546zaoxn author: nan title: Publication only date: 2006-03-08 pages: extension: .txt txt: ./txt/cord-014976-546zaoxn.txt cache: ./cache/cord-014976-546zaoxn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-014976-546zaoxn.txt' === file2bib.sh === id: cord-023017-k6edtg58 author: nan title: AASLD Abstracts (pp. 282A–382A) date: 2006-02-10 pages: extension: .txt txt: ./txt/cord-023017-k6edtg58.txt cache: ./cache/cord-023017-k6edtg58.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-023017-k6edtg58.txt' === file2bib.sh === id: cord-005777-6rvfsx4p author: nan title: PS 0420-0716 date: 2007-08-25 pages: extension: .txt txt: ./txt/cord-005777-6rvfsx4p.txt cache: ./cache/cord-005777-6rvfsx4p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-005777-6rvfsx4p.txt' === file2bib.sh === id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 pages: extension: .txt txt: ./txt/cord-014538-6a2pviol.txt cache: ./cache/cord-014538-6a2pviol.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-014538-6a2pviol.txt' === file2bib.sh === id: cord-015126-cyhcbk1j author: nan title: PS 0036-0344 date: 2007-08-25 pages: extension: .txt txt: ./txt/cord-015126-cyhcbk1j.txt cache: ./cache/cord-015126-cyhcbk1j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-015126-cyhcbk1j.txt' === file2bib.sh === id: cord-006876-v2m5l5wz author: nan title: Neurocritical Care Society 14(th) Annual Meeting date: 2016-08-11 pages: extension: .txt txt: ./txt/cord-006876-v2m5l5wz.txt cache: ./cache/cord-006876-v2m5l5wz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-006876-v2m5l5wz.txt' === file2bib.sh === id: cord-005478-5iu38pr6 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session date: 2019-07-03 pages: extension: .txt txt: ./txt/cord-005478-5iu38pr6.txt cache: ./cache/cord-005478-5iu38pr6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-005478-5iu38pr6.txt' === file2bib.sh === id: cord-005646-xhx9pzhj author: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 pages: extension: .txt txt: ./txt/cord-005646-xhx9pzhj.txt cache: ./cache/cord-005646-xhx9pzhj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-005646-xhx9pzhj.txt' === file2bib.sh === id: cord-015369-72cjogxz author: nan title: 50th Annual Meeting of the Austrian Society of Surgery. Vienna, June 18–20, 2009. Guest Editors: Albert Tuchmann, Erhard Schwanzer, Benedikt Walzel date: 2009 pages: extension: .txt txt: ./txt/cord-015369-72cjogxz.txt cache: ./cache/cord-015369-72cjogxz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-015369-72cjogxz.txt' === file2bib.sh === id: cord-021555-rrverrsj author: Delano, Margaret L. title: Biology and Diseases of Ruminants: Sheep, Goats, and Cattle date: 2007-09-02 pages: extension: .txt txt: ./txt/cord-021555-rrverrsj.txt cache: ./cache/cord-021555-rrverrsj.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-021555-rrverrsj.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 8272 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-005816-i54q5gsu author: nan title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 pages: extension: .txt txt: ./txt/cord-005816-i54q5gsu.txt cache: ./cache/cord-005816-i54q5gsu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-005816-i54q5gsu.txt' === file2bib.sh === id: cord-015024-2xzc0uc5 author: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 pages: extension: .txt txt: ./txt/cord-015024-2xzc0uc5.txt cache: ./cache/cord-015024-2xzc0uc5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-015024-2xzc0uc5.txt' === file2bib.sh === id: cord-006880-9dgmdtj8 author: nan title: Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date: 2012-09-19 pages: extension: .txt txt: ./txt/cord-006880-9dgmdtj8.txt cache: ./cache/cord-006880-9dgmdtj8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-006880-9dgmdtj8.txt' === file2bib.sh === id: cord-006182-kck5e1ry author: nan title: 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date: 2019-10-01 pages: extension: .txt txt: ./txt/cord-006182-kck5e1ry.txt cache: ./cache/cord-006182-kck5e1ry.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-006182-kck5e1ry.txt' === file2bib.sh === id: cord-335975-m6lkrehi author: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 pages: extension: .txt txt: ./txt/cord-335975-m6lkrehi.txt cache: ./cache/cord-335975-m6lkrehi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-335975-m6lkrehi.txt' === file2bib.sh === id: cord-005727-li8pwigg author: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 pages: extension: .txt txt: ./txt/cord-005727-li8pwigg.txt cache: ./cache/cord-005727-li8pwigg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-005727-li8pwigg.txt' === file2bib.sh === id: cord-014464-m5n250r2 author: Sole-Violan, J title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 pages: extension: .txt txt: ./txt/cord-014464-m5n250r2.txt cache: ./cache/cord-014464-m5n250r2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 21 resourceName b'cord-014464-m5n250r2.txt' === file2bib.sh === id: cord-341063-3rqnu5bu author: nan title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 pages: extension: .txt txt: ./txt/cord-341063-3rqnu5bu.txt cache: ./cache/cord-341063-3rqnu5bu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-341063-3rqnu5bu.txt' === file2bib.sh === id: cord-005497-w81ysjf9 author: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 pages: extension: .txt txt: ./txt/cord-005497-w81ysjf9.txt cache: ./cache/cord-005497-w81ysjf9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 22 resourceName b'cord-005497-w81ysjf9.txt' === file2bib.sh === id: cord-006870-f5w6fw6q author: nan title: Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting date: 2017-09-19 pages: extension: .txt txt: ./txt/cord-006870-f5w6fw6q.txt cache: ./cache/cord-006870-f5w6fw6q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 21 resourceName b'cord-006870-f5w6fw6q.txt' === file2bib.sh === id: cord-023095-4dannjjm author: nan title: Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011 date: 2011-05-03 pages: extension: .txt txt: ./txt/cord-023095-4dannjjm.txt cache: ./cache/cord-023095-4dannjjm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-023095-4dannjjm.txt' === file2bib.sh === id: cord-015021-pol2qm74 author: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 pages: extension: .txt txt: ./txt/cord-015021-pol2qm74.txt cache: ./cache/cord-015021-pol2qm74.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-015021-pol2qm74.txt' === file2bib.sh === id: cord-005814-ak5pq312 author: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 pages: extension: .txt txt: ./txt/cord-005814-ak5pq312.txt cache: ./cache/cord-005814-ak5pq312.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-005814-ak5pq312.txt' === file2bib.sh === id: cord-010119-t1x9gknd author: nan title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date: 2017-09-04 pages: extension: .txt txt: ./txt/cord-010119-t1x9gknd.txt cache: ./cache/cord-010119-t1x9gknd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-010119-t1x9gknd.txt' === file2bib.sh === id: cord-006849-vgjz74ts author: nan title: 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date: 2019-09-13 pages: extension: .txt txt: ./txt/cord-006849-vgjz74ts.txt cache: ./cache/cord-006849-vgjz74ts.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 14 resourceName b'cord-006849-vgjz74ts.txt' === file2bib.sh === id: cord-005453-4057qib7 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 pages: extension: .txt txt: ./txt/cord-005453-4057qib7.txt cache: ./cache/cord-005453-4057qib7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 19 resourceName b'cord-005453-4057qib7.txt' === file2bib.sh === id: cord-005460-ezrn8cva author: nan title: Physicians – Poster Session date: 2017-07-28 pages: extension: .txt txt: ./txt/cord-005460-ezrn8cva.txt cache: ./cache/cord-005460-ezrn8cva.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 47 resourceName b'cord-005460-ezrn8cva.txt' Que is empty; done keyword-day-cord === reduce.pl bib === id = cord-000705-w52dc97h author = Ríos, Fernando G title = Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic date = 2011-08-17 pages = extension = .txt mime = text/plain words = 4859 sentences = 301 flesch = 48 summary = METHOD: This was a multicenter, prospective inception cohort study including adult patients with acute respiratory failure requiring mechanical ventilation (MV) admitted to 20 ICUs in Argentina between June and September of 2009 during the influenza A (H1N1) pandemic. Although a mild form of the disease was prevalent, it soon became evident that the 2009 influenza A (H1N1) virus could also provoke severe, acute respiratory failure requiring admission to the intensive care unit (ICU) for mechanical ventilation [16] , which was reflected in the severe pathological injury found at autopsy [17] . This was a multicenter, inception cohort study that included patients aged > 15 years admitted to the ICU with a previous history of influenza-like illness, evolving to acute respiratory failure that required mechanical ventilation during the 2009 winter in the Southern Hemisphere. We report on a large, prospective cohort of 2009 influenza A (H1N1) patients that were mechanically ventilated for acute respiratory failure due to diffuse pneumonitis during the pandemic in Argentina. cache = ./cache/cord-000705-w52dc97h.txt txt = ./txt/cord-000705-w52dc97h.txt === reduce.pl bib === id = cord-000059-5hwqdnx1 author = Tokars, Jerome I. title = Enhancing Time-Series Detection Algorithms for Automated Biosurveillance date = 2009-04-17 pages = extension = .txt mime = text/plain words = 4407 sentences = 207 flesch = 54 summary = At a constant alert rate of 1%, sensitivity was improved for both datasets by using a minimum standard deviation (SD) of 1.0, a 14–28 day baseline duration for calculating mean and SD, and an adjustment for total clinic visits as a surrogate denominator. These enhanced methods may increase sensitivity without increasing the alert rate and may improve the ability to detect outbreaks by using automated surveillance system data. For the DoD and hospital ED datasets, sensitivity was improved by using a higher minimum SD of 1.0, a longer baseline duration of 28 days, and adjusting for total visits. Stratifi cation by weekday versus weekend day improves expected value calculations when a substantial day-of-week effect exists, such as in the DoD data. Sensitivity of detecting various numbers of additional counts, by using initial versus best algorithms for hospital emergency department chief complaint data, for selected BioSense data. cache = ./cache/cord-000059-5hwqdnx1.txt txt = ./txt/cord-000059-5hwqdnx1.txt === reduce.pl bib === id = cord-002957-gw2cow0d author = Gray, Darren W. title = DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles date = 2018-04-05 pages = extension = .txt mime = text/plain words = 7426 sentences = 323 flesch = 36 summary = The aims of the current study were therefore to assess the performance of Reverse Phase (RP) and Hydrophobic Interaction Liquid Chromatography (HILIC) separation methods for Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) metabolomic profiling of bovine plasma and identify plasma metabolomic markers capable of differentiating between vaccinated and nonvaccinated calves following intranasal challenge with BPI3V. The selected panel of 383 unique AMRTPs (S3 Table) differentiating animals of different vaccination status at various time-points post-BPI3V challenge were deconvoluted to identify parent ion mass, adducts and low energy fragments using low and high energy data (Function 1 and 2 respectively), yielding 26 parent ions for elemental composition determination. The metabolomic profiling performed here in this study on post-BPI3V challenge acquired samples, has identified a unique panel of plasma metabolites which differ between vaccinated and non-vaccinated animals, and significantly are involved in recognised immune response mechanisms. cache = ./cache/cord-002957-gw2cow0d.txt txt = ./txt/cord-002957-gw2cow0d.txt === reduce.pl bib === id = cord-001192-zbogocki author = van Meer, Maurits PA title = Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report date = 2014-01-30 pages = extension = .txt mime = text/plain words = 4217 sentences = 229 flesch = 47 summary = A 23-year-old healthy male volunteer took part in a clinical trial in which the volunteer took chloroquine chemoprophylaxis and received three intradermal doses at four-week intervals of aseptic, purified Plasmodium falciparum sporozoites to induce protective immunity against malaria. Here, a very probable case of acute myocarditis is described in a volunteer who had taken chloroquine chemoprophylaxis, was inoculated three times at fourweek intervals with PfSPZ Challenge, received six travelrelated routine vaccines after this immunization procedure, had CHMI by the bites of five PfSPZ-infected mosquitoes 8.5 weeks after the last dose of PfSPZ Challenge and 4.5 weeks after the last dose of chloroquine, had a sore throat on day 9 after CHMI, developed P. Fatal myocarditis in course of Plasmodium falciparum infection: case report and review of cardiac complications in malaria Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report cache = ./cache/cord-001192-zbogocki.txt txt = ./txt/cord-001192-zbogocki.txt === reduce.pl bib === id = cord-002659-566uoozj author = Fujimoto, Yousuke title = Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection date = 2017-08-22 pages = extension = .txt mime = text/plain words = 4768 sentences = 275 flesch = 57 summary = Cytokine levels and virus titres in bronchoalveolar lavage fluid from mice with and without asthma after A(H1N1)pdm09 or seasonal H1N1 infection were examined. Virus titres in asthma/A(H1N1)pdm09 mice were highest at 3 days post-infection, and decreased by 7 days post-infection, although the levels at this time point were still higher than that in any other group. In the present study, we investigated the sequential changes in intra-tracheal cytokine production, viral loads, and pulmonary inflammation in a mouse model of bronchial asthma during the first 7 days after A(H1N1)pdm09 or seasonal H1N1 influenza infection. In contrast, the levels in control mice increased to 161.4 pg/mL by 3 days post-seasonal virus infection, which were similar to those in asthma/A(H1N1)pdm09 mice (p = 1.00), and these levels were maintained until 7 days post-infection. The notable findings in the present study were the early peak in both IL-6 and TNF-α levels, the high inflammatory cell infiltration in BAL fluids, and the severe pulmonary inflammation at 3 days post-infection in asthmatic/A(H1N1)pdm09 mice. cache = ./cache/cord-002659-566uoozj.txt txt = ./txt/cord-002659-566uoozj.txt === reduce.pl bib === id = cord-003533-8m0vyxq8 author = Jayathilaka, P. G. N. S. title = An outbreak of leptospirosis with predominant cardiac involvement: a case series date = 2019-03-18 pages = extension = .txt mime = text/plain words = 4148 sentences = 280 flesch = 50 summary = We present a case series of severe leptospirosis with cardiac involvement observed during a period of one month at Colombo-North Teaching Hospital, Sri Lanka. CASE PRESENTATION: We report here five patients with severe leptospirosis complicated with cardiac involvement, admitted to a single medical ward, Colombo-North Teaching Hospital, Sri Lanka during a one-month period. In this case series, we describe a series of male patients with severe leptospirosis with cardiac involvement, presented to a single medical ward during a period of one month. By day eleven of illness he was completely recovered clinically and full blood count, liver function tests, renal function tests and ECG were normal. Patient was discharged from the ward on day 7 of illness with complete recovery and normal full blood count, renal and liver function tests. Despite adequate fluid resuscitation patient developed shock with low urine output on the same day of admission. cache = ./cache/cord-003533-8m0vyxq8.txt txt = ./txt/cord-003533-8m0vyxq8.txt === reduce.pl bib === id = cord-000097-vueo83vk author = Beretta, Chiara title = Prolonged extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome in a child affected by rituximab-resistant autoimmune hemolytic anemia: a case report date = 2009-04-01 pages = extension = .txt mime = text/plain words = 2841 sentences = 153 flesch = 42 summary = title: Prolonged extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome in a child affected by rituximab-resistant autoimmune hemolytic anemia: a case report Recently, the use of monoclonal antibodies (rituximab) has allowed sustained remissions to be obtained in the majority of pediatric patients with refractory autoimmune hemolytic anemia. While still on steroid therapy, the patient developed an interstitial pneumonia with Acute Respiratory Distress Syndrome, which required immediate admission to the intensive care unit where extracorporeal membrane oxygenation therapy was administered continuously for 37 days. CONCLUSIONS: This case shows that aggressive combined immunosuppressive therapy may lead to a sustained complete remission in children with refractory autoimmune hemolytic anemia. One month after the end of the first course of rituximab, while still receiving low-dose steroids, the patient presented with a clinical relapse of AIHA, so prednisone was increased to 2mg/kg/day and two further rituximab infusions were performed ( Figure 1 ). cache = ./cache/cord-000097-vueo83vk.txt txt = ./txt/cord-000097-vueo83vk.txt === reduce.pl bib === id = cord-007178-h0ordzm9 author = Felts, Paul A. title = Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide date = 2005-05-04 pages = extension = .txt mime = text/plain words = 9492 sentences = 425 flesch = 47 summary = At this interval the lesion was clearly discernible using differential interference contrast optics as a region of tissue disruption in the dorsal funiculus, allowing AdPC-positive cells to be counted in both demyelinated and apparently normal areas of the dorsal funiculus of LPS-injected animals. Spinal cords injected with saline ( Fig. 1) showed damage restricted to a very small number of axons undergoing either Table 1 Populations of inflammatory cells present in the spinal cord at various times following the injection of LPS or saline into the dorsal funiculus Wallerian degeneration or demyelination. The cells were often adjacent to large blood vessels, and they formed only a small subset of the substantial population of ED1-positive Fig. 7 Light micrographs showing GFAP immunoreactivity at the interface between the dorsal funiculus (DF) and the grey matter (GM) in an animal 7 days after the injection of LPS into the spinal cord. cache = ./cache/cord-007178-h0ordzm9.txt txt = ./txt/cord-007178-h0ordzm9.txt === reduce.pl bib === id = cord-015389-vwgai4k9 author = nan title = Publication only date = 2009-03-25 pages = extension = .txt mime = text/plain words = 23868 sentences = 1465 flesch = 57 summary = This study evaluates the safety of this approach, in terms of infusion-related toxicity and hematopoietic reconstitution, in 385 consecutive autologous transplantations performed from 4/97 to 9/08 in 348 patients (median age 46; underlying disease: lymphoma in 178, myeloma in 131, acute leukaemia in 17, breast cancer in 22). Patients and methods: Eight pts after allogeneic hematopoetic stem cell transplantation (HSCT) underwent MSCs infusions (median age of pts was 11 years, male/female: 6/2) between 2006 and 2009. Akiyama Tokyo Metropolitan Komagome Hospital (Tokyo, JP) Acute graft-versus-host disease (GVHD) is one of the major factors that have infl uence on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). Material and methods: during a 8 years period we have performed 144 stem cells transplantation in 134 patients with different hematological malignancies(AML: 74; ALL: 6; CML: 7; CLL: 1, NHL: 13; Hodgkin Diseases: 16; Multiple myelomas: 24; Aplastic anaemia: 1;Myelofi brosis:1 Ewing Sarcoma: 1; Male:78 Female 66. cache = ./cache/cord-015389-vwgai4k9.txt txt = ./txt/cord-015389-vwgai4k9.txt === reduce.pl bib === id = cord-001262-8s7g2wvd author = Zheng, Guoping title = Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study date = 2014-04-04 pages = extension = .txt mime = text/plain words = 4924 sentences = 286 flesch = 52 summary = title: Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study The objectives of this study were first to examine the possible adverse events after systemic administration of allogeneic adipose-derived MSCs in ARDS patients and second to determine potential efficacy of MSCs on ARDS. METHODS: Twelve adult patients meeting the Berlin definition of acute respiratory distress syndrome with a PaO(2)/FiO(2) ratio of < 200 were randomized to receive allogeneic adipose-derived MSCs or placebo in a 1:1 fashion. Many studies, including publications from our group [11, 12] , have demonstrated compelling evidence of the benefits of MSCs from both bone marrow [13] [14] [15] and adipose tissues [16] [17] [18] in animal models for lung injury and ARDS. In this randomized, placebo-controlled phase I clinical trial, the primary goal was to evaluate the safety and feasibility of systemic administration of allogeneic adipose-derived MSCs in ARDS patients. cache = ./cache/cord-001262-8s7g2wvd.txt txt = ./txt/cord-001262-8s7g2wvd.txt === reduce.pl bib === id = cord-006876-v2m5l5wz author = nan title = Neurocritical Care Society 14(th) Annual Meeting date = 2016-08-11 pages = extension = .txt mime = text/plain words = 59719 sentences = 3440 flesch = 47 summary = We conducted a prospective cohort study among mild and moderate-severe TBI patients admitted to a level 1 trauma center with these inclusion criteria: 1) Age < 65 years, 2) No severe non-TBI injuries, 3) No prior cardiac disease, and 4) Minimal comorbidities. In most instances, DC has been performed based on neurosurgical evaluation of the patient with or without intracranial pressure (ICP) monitoring and evidence of increased shown variable outcomes in emergency (within 4 hours of injury) neurosurgical procedure in Traumatic Brain Injury (TBI). This is an observational cohort study of adult patients (>18 years) in a 10-bed NSICU at an academic, tertiary care center evaluating quality outcome measures pre-and post-neurointensivists. Intensivists in neuro ICU must consistently assess and treat the non-neurological complications in traumatic brain and spine-injured patients and deliver appropriate care to bring down the mortality and morbidity and improve outcome. cache = ./cache/cord-006876-v2m5l5wz.txt txt = ./txt/cord-006876-v2m5l5wz.txt === reduce.pl bib === id = cord-007288-lzxi6q1p author = Pazin, George J. title = Leukocyte Interferon for Treating First Episodes of Genital Herpes in Women date = 1987-12-17 pages = extension = .txt mime = text/plain words = 4199 sentences = 226 flesch = 52 summary = Women experiencing their first episodes of genital herpes were treated, beginning within three days of the onset of lesions, with 5 × 10(4) units of human leukocyte interferon/kg of body weight for 12 doses over 14 days (total, ∼3.6 × 10(7) units) or with placebo in equivalent volumes. We clinically and virologically assessed the effect of early treatmentwith leukocyte interferon (Cantellvariety) [13] on the initial episode of' genital herpes.Weindirectly evaluated the effect of .interferon on latency by determining the incidence and frequency of both asymptomatic reactivations and symptomatic recurrences during an intensive one-year follow-up period. Overall, interferon treatment at rv3 x 10 6 U/day had an ameliorative effect on both shedding of virus and the time to healing of initial episodes of genital herpes, but had no significant effect on the associated pain. cache = ./cache/cord-007288-lzxi6q1p.txt txt = ./txt/cord-007288-lzxi6q1p.txt === reduce.pl bib === id = cord-002945-29nj4f05 author = Ambrose, Rebecca K. title = In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c) date = 2018-01-19 pages = extension = .txt mime = text/plain words = 6608 sentences = 664 flesch = 63 summary = Detection of bovine viral diarrhoea virus 1 subgenotype 1c in extracts from cattle samples using quantitative real time PCR (qPCR). For cattle infected with BVDV-1c strain Trangie, one of the four animals tested positive on Day 2 post-infection, while all the other samples were negative throughout the sampling period (Table 1) . For cattle infected with BVDV-1c strain Trangie, one of the four animals tested positive on Day 2 post-infection, while all the other samples were negative throughout the sampling period (Table 1) . BVDV-1c was not detected via qPCR in the nasal swab or serum samples collected from all animals on Day 21, Day 28, Day 42 and Day 55 post-infection and were deemed to be negative (data not shown). BVDV-1c was not detected via qPCR in the nasal swab or serum samples collected from all animals on Day 21, Day 28, Day 42 and Day 55 post-infection and were deemed to be negative (data not shown). cache = ./cache/cord-002945-29nj4f05.txt txt = ./txt/cord-002945-29nj4f05.txt === reduce.pl bib === id = cord-010130-28bt3x25 author = Crocchiolo, R. title = Infections after T‐replete haploidentical transplantation and high‐dose cyclophosphamide as graft‐versus‐host disease prophylaxis date = 2015-03-26 pages = extension = .txt mime = text/plain words = 3519 sentences = 175 flesch = 46 summary = RESULTS: After a median follow‐up of 23 months, cumulative incidence of viral infections was 70% (95% confidence interval [CI] 59–81) at 100 days and 77% (95% CI 67–87) at 1 year; 35 of 65 patients at risk had CMV reactivation (54%) and the rate of polyomavirus‐virus‐associated cystitis was 19% (13/70). In the present analysis, we described infectious complications after unmanipulated, T-cell replete haplo-HSCT using post-transplant Cy in 70 consecutive patients and found, aside from a high incidence of viral infections/reactivations, especially in the early posttransplant period, a quite low incidence of late bacterial infections, together with a very low incidence of IFIs after day +180 (2 events in the overall 11 observed). In conclusion, the present single-center data on 70 consecutive patients receiving T-cell replete haplo-HSCT with post-transplant Cy confirm a high rate of viral infections before day +100 and a lower incidence of infections afterward, suggesting a satisfactory although non-optimal immune reconstitution after this type of transplantation. cache = ./cache/cord-010130-28bt3x25.txt txt = ./txt/cord-010130-28bt3x25.txt === reduce.pl bib === id = cord-018239-n7axd9bq author = Rusoke-Dierich, Olaf title = Travel Medicine date = 2018-03-13 pages = extension = .txt mime = text/plain words = 8527 sentences = 660 flesch = 60 summary = The following topics should be included in the travel advice consultation: 5 Vaccinations (general and country specific) 5 Country-specific diseases 5 Malaria prophylaxis 5 Mosquito prophylaxis (wearing bright long-sleeved clothes, avoiding perfume, staying in air-conditioned rooms, using a mosquito net, using insect repellents, staying inside at dawn and dusk) 5 Food consumption and drinking overseas (no consumption of ice cubes, uncooked meals, salads and food, which is exposed to flies, limited alcohol consumption) 5 UV protection (using sun cream, avoiding sun exposure between 11.00 and 15.00 o' clock, remaining in shaded areas, wearing a hat and covering skin) 5 Fitness assessment for travelling, flying and diving 5 Challenges of different climates and their effects on the personal health (dehydration, hyperthermia) 5 Medications 5 Thrombosis counselling 5 Counselling on symptoms on return, which require review (fever, skin changes, abnormal bleeding, lymphadenopathy, diarrhoea) 5 Sexual transmitted diseases 5 Contraception 5 Rabies cache = ./cache/cord-018239-n7axd9bq.txt txt = ./txt/cord-018239-n7axd9bq.txt === reduce.pl bib === id = cord-163587-zjnr7vwm author = Altmejd, Adam title = Nowcasting Covid-19 statistics reported withdelay: a case-study of Sweden date = 2020-06-11 pages = extension = .txt mime = text/plain words = 3508 sentences = 225 flesch = 62 summary = In this paper we describe a statistical methodology for nowcasting the epidemic statistics, such as hospitalizations or deaths, and their degrees of uncertainty, based on the daily reported event frequency and the observed distribution pattern of reporting delays. We propose to use the removal method, developed in animal management (Pollock, 1991) , to present an estimate of the actual frequencies at a given day and their uncertainty. To account for this, we allow the estimated proportions of daily reported cases to follow a probability distribution taking into consideration what type of day it is. We propose a Bayesian version of the removal model that assumes an overdispersed binomial distribution for the daily observations of deaths in Sweden in COVID-19. Another limitation is that the model assumes that the number of new reported deaths for a given day cannot be negative, which is not actually true, due to miscount or misclassification of days. cache = ./cache/cord-163587-zjnr7vwm.txt txt = ./txt/cord-163587-zjnr7vwm.txt === reduce.pl bib === id = cord-032240-xswtx940 author = Sauer, François title = Pericardial effusion in patients with COVID-19: case series date = 2020-09-09 pages = extension = .txt mime = text/plain words = 2235 sentences = 167 flesch = 51 summary = Case 1 was a COVID-19 cardiac tamponade without myocarditis, confirmed by a positive chest computed tomography (CT) scan. Case 3 was a cardiac tamponade due to COVID-19 pericarditis, with a positive polymerase chain reaction on pericardial fluid. Since the outbreak of clusters of viral pneumonia due to the novel coronavirus (severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2) in Wuhan, China in December 2019, 1 coronavirus disease 2019 (COVID-19) has spread worldwide infecting more than 5.4 million people and causing more than 349 095 deaths as of 27 May 2020. • Three cases of pericardial effusions (PEs) comprising two tamponades occurred in a single cardiology centre, suggesting a higher cardiac risk than expected during the coronavirus disease 2019 (COVID-19) pandemic. [3] [4] [5] [6] [7] We hereby report a case series of three patients with cardiac and pericardial manifestations of COVID-19 at our institution. Acute myopericarditis with pericardial effusion and cardiac tamponade in a patient with COVID-19 cache = ./cache/cord-032240-xswtx940.txt txt = ./txt/cord-032240-xswtx940.txt === reduce.pl bib === id = cord-034257-kl2ccmz5 author = de Jonge, Jeroen C. title = PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment date = 2020-10-26 pages = extension = .txt mime = text/plain words = 3731 sentences = 209 flesch = 51 summary = title: PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment AIMS AND DESIGN: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke (PRECIOUS) is an international, multi-centre, 3 × 2 factorial, randomised, controlled, open-label clinical trial with blinded outcome assessment, which will assess whether prevention of aspiration, infections, or fever with metoclopramide, ceftriaxone, paracetamol, respectively, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in elderly patients with acute stroke. The primary objective is to assess whether prevention of aspiration, infections, or fever with metoclopramide, ceftriaxone, paracetamol, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in older patients with acute stroke. cache = ./cache/cord-034257-kl2ccmz5.txt txt = ./txt/cord-034257-kl2ccmz5.txt === reduce.pl bib === id = cord-021453-vf8xbaug author = Dysko, Robert C. title = Biology and Diseases of Dogs date = 2007-09-02 pages = extension = .txt mime = text/plain words = 41994 sentences = 2688 flesch = 48 summary = The use of dogs continued as biomedical research advanced, and they were featured in many noteworthy studies, including those by Pavlov to observe and document the conditioned reflex response and by Banting and Best to identify the role of insulin in diabetes mellitus. Especially noted in this chapter are infectious diseases associated with the use of random-source dogs that have unknown vaccination history and have had intensive contact with other similar animals at pounds and/or shelters, or conditions seen frequently in the beagle, the most common breed used in biomedical research. Culture requires selective isolation media, and growth is favored by reduced oxygen tension and a temperature of 42~ Any disorder that can cause diarrhea in dogs should be considered as a differential diagnosis, including canine parvovirus, coronavirus, distemper virus, Giardia, and Salmonella infections; helminth infestations; and hemorrhagic gastroenteritis. cache = ./cache/cord-021453-vf8xbaug.txt txt = ./txt/cord-021453-vf8xbaug.txt === reduce.pl bib === id = cord-224211-6lsvjfqb author = Schaback, Robert title = Modelling Recovered Cases and Death Probabilities for the COVID-19 Outbreak date = 2020-03-26 pages = extension = .txt mime = text/plain words = 814 sentences = 56 flesch = 70 summary = title: Modelling Recovered Cases and Death Probabilities for the COVID-19 Outbreak From March 23rd, the data for the recovered cases of COVID-19 are missing from the standard repository maintained by the Johns Hopkins University in collaboration with the WHO. But since data concerning recovered patients are extremely important for modelling the COVID-19 outbreak, a method for estimating the missing data is provided and tested. As a byproduct, it produces estimates for the probabilities to die $k$ days after confirmation, or to survive after $d$ days. The COVID-19 repository [1] at Johns Hopkins University provides cumulative data on • Confirmed infected persons (C) and Authorities only report confirmed cases and deaths, but they say [2] that a person with mild or no symptoms is considered to be recovered after 14 days. This is automatically cumulative and maintains the integrity of person counts between the Confirmed, Deaths, and Recovered. cache = ./cache/cord-224211-6lsvjfqb.txt txt = ./txt/cord-224211-6lsvjfqb.txt === reduce.pl bib === id = cord-029112-u507i0t0 author = Smith, Keisha title = A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date = 2020-07-13 pages = extension = .txt mime = text/plain words = 20880 sentences = 1243 flesch = 46 summary = Study ALXN1210-COV-305 is a multicenter Phase 3, open-label, randomized, controlled study designed to evaluate the safety and efficacy of intravenous (IV) ravulizumab + best supportive care (BSC), compared with BSC alone in patients with a confirmed diagnosis of SARS-CoV-2 infection, and a clinical presentation consistent with COVID-19 severe pneumonia, acute lung injury, or ARDS. cache = ./cache/cord-029112-u507i0t0.txt txt = ./txt/cord-029112-u507i0t0.txt === reduce.pl bib === id = cord-030957-45tc5ksf author = Schaap, Andrew title = The politics of precarity date = 2020-08-28 pages = extension = .txt mime = text/plain words = 14972 sentences = 570 flesch = 45 summary = In the final chapters, Apostolidis explores how worker centres might also function synecdochally insofar as the purpose of association is construed not only instrumentally, as protection against the risks associated with precarity, but in terms of their constitutive potential to sustain convivial networks of political possibility for more mutually supportive, creative and pluralistic forms of solidarity than those afforded by traditional unionised spaces. Paul Apostolidis' book The Fight for Time encapsulates a very similar kind of intellectual-political project as it also seeks to capture the self-understandings of migrant day labourers in their everyday struggles, to reflect on how they resonate with contemporary critical theoretical concepts and to learn how, taken together, these empirical and conceptual insights may lead us to a renewed vision of what a left politics might look like for our age. cache = ./cache/cord-030957-45tc5ksf.txt txt = ./txt/cord-030957-45tc5ksf.txt === reduce.pl bib === id = cord-027811-vk3qnumx author = Freedberg, Daniel E. title = Impact of Fiber-Based Enteral Nutrition on the Gut Microbiome of ICU Patients Receiving Broad-Spectrum Antibiotics: A Randomized Pilot Trial date = 2020-06-11 pages = extension = .txt mime = text/plain words = 3836 sentences = 201 flesch = 50 summary = title: Impact of Fiber-Based Enteral Nutrition on the Gut Microbiome of ICU Patients Receiving Broad-Spectrum Antibiotics: A Randomized Pilot Trial CONCLUSIONS: Enteral fiber was associated with nonsignificant trends toward increased relative abundance of short-chain fatty acid–producing bacteria and increased short-chain fatty acid levels among ICU patients receiving broad-spectrum IV antibiotics. This pilot study was designed to test the hypothesis that fiber-based enteral nutrition increases the levels of SCFA-producing bacteria and SCFA levels in ICU patients receiving broad-spectrum IV antibiotics, with a goal of generating effect size estimates that could be used as the basis for future studies involving fiber. A study testing 7 days of 7 g/d inulin versus maltodextrin supplementation in 22 ICU adults initiating enteral nutrition found no difference in fecal abundance of Faecalibacterium prausnitzii or Bifidobacteria, or in fecal SCFA levels (24) . cache = ./cache/cord-027811-vk3qnumx.txt txt = ./txt/cord-027811-vk3qnumx.txt === reduce.pl bib === id = cord-027259-f4sgobcz author = Metsker, Oleg title = Stroke ICU Patient Mortality Day Prediction date = 2020-05-23 pages = extension = .txt mime = text/plain words = 5328 sentences = 204 flesch = 42 summary = On the basis of the analysis of 12 modern prognostic models from 10 countries we can identify some of the most stable (main) predictors for the causes of intra-hospital mortality: age [16, [20] [21] [22] [23] [24] ; type of stroke [25] ; lesion location [25] ; level of consciousness [11, 20, 23, 25, 26] upon admission; NIHSS stroke severity [10, 21, 22, 24] ; comorbidity [22, 27] , Charlson comorbidity index [23] , Atrial fibrillation [11, 22] , case history Transitor ischemic attack (TIA) [31]; hospital complications (high intracranial pressure) [16] , pneumonia, seizures, anxiety/depression, infections, limb pains and constipation [22, 27] . Early mortality in each subgroup was associated with a number of demographic, clinical, and instrumental-laboratory characteristics based on the interpretation of the results of calculating the significance of predictors of binary classification models by machine learning methods from the Scikit-Learn library 2 . cache = ./cache/cord-027259-f4sgobcz.txt txt = ./txt/cord-027259-f4sgobcz.txt === reduce.pl bib === id = cord-009772-pzxvicee author = GRÜNBERG, K. title = Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo date = 2006-04-27 pages = extension = .txt mime = text/plain words = 4953 sentences = 350 flesch = 58 summary = title: Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo Conclusion We conclude that the severity of cold, as induced by experimental RV16 infection, is a determinant of the increase in airway hypersensitivity to histamine in patients with asthma. Since none of these studies was placebo-controlled, it seems mandatory to examine the effect of experimental rhinovirus infection on airway sensitivity to histamine in asthmatic subjects by using such a design. In the present study, we hypothesized that experimental RVI6 colds in atopic asthmatic patients increase airway sensitivity to histamine. During the course of the study, there were no significant effects on baseline FEV| within either the placebo group or in the RVl 6-treated subjects with a mild or severe cold (MANOVA, P -0.99) ( Figure 1 ). Two previous studies on experimental rhinovirus infection in asthma [!3.14| showed small and variable changes in airway hypersensitivity. cache = ./cache/cord-009772-pzxvicee.txt txt = ./txt/cord-009772-pzxvicee.txt === reduce.pl bib === id = cord-271298-7vk3wgw1 author = Sato, Tomoi title = Feeding behavior during sialodacryoadenitis viral infection in rats date = 2001-04-30 pages = extension = .txt mime = text/plain words = 3278 sentences = 169 flesch = 49 summary = This pattern of decreased food intake is similar to that occurring during indomethacin-induced ulcerative ileitis, where we previously measured an increase in plasma tumor-necrosis factor (TNF)-α. The differences in the decrease in the feeding pattern between the SDA viral and a bacterial infection suggest that factors other than TNF-α alone play a significant role in the mechanism of anorexia during a viral infection. An Automated Computerized Rat Eater Meter (ACREM; [7] ), which measures individual meal size and meal number as well as food intake for prolonged periods, provides us with the ability to characterize the biological manifestations associated with feeding behavior including anorexia. Since these cytokines act on the hypothalamus to modulate food intake and feeding behavior, they might have a direct or an indirect influence on the LHA to decrease meal size and on the VMN to inhibit a compensatory increase in meal number during the SDA virus infection. cache = ./cache/cord-271298-7vk3wgw1.txt txt = ./txt/cord-271298-7vk3wgw1.txt === reduce.pl bib === id = cord-266183-uzuda3ir author = Renieris, Georgios title = Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Corona virus date = 2020-05-18 pages = extension = .txt mime = text/plain words = 2204 sentences = 143 flesch = 49 summary = In light of these observations suggesting a pivotal role of H2S in the pathogenesis of Covid-19, we studied the serum levels of H2S and its association with final outcome in a cohort of patients with Covid-19 pneumonia. Due to the described anti-inflammatory properties, we hypothesize that elevated levels of H2S in serum are associated with a favourable outcome of Covid-19 pneumonia. Pneumonia Severity Index (PSI) (9); (iii) absolute blood cell counts and biochemistry on admission and follow-up; and 28-day survival. Following ROC curve analysis, it was found that serum levels of H2S on day 1 lower than 150.44μΜ had the best trade-off for sensitivity and specificity for death (Figure 3Aand B ). Forward stepwise Cox regression analysis showed that serum H2S on day 1 above 150.44μM is an independent protective factor for unfavourable outcome of COVID-19 even in the presence of severity scores (Table 1) . cache = ./cache/cord-266183-uzuda3ir.txt txt = ./txt/cord-266183-uzuda3ir.txt === reduce.pl bib === id = cord-006391-esnsa4u5 author = nan title = Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date = 1982 pages = extension = .txt mime = text/plain words = 44844 sentences = 2433 flesch = 50 summary = In our parallel tests using an excision-sample technique [2] which is considerably more sensitive than the DGHM procedure, we have observed the following mean reductions in the counts of accessible bacteria: iodine in ethanol, 96%; povidone-iodine, 89%; chlorhexidine in ethanol, 88%; iso-propanol, The purpose of this study was to compare radiation injury in Guinea Pig small bowel (1) devoid of contents (2) containing bile (3) containing pancreatic juice. Studies in vitro employing isolated perfused rat pancreas and stomach revealed following results: Mean basal pancreatic somatostatin release in normal, diabetic and transplanted rats were 12___3, 24-t-7, and 17__+4 pg/ml, respectively. As these changes appear closely correlated to the blood glucose levels which show a 30 % decrease at 4 h and progressive restoration towards normal values up to 24 h, attempts have been made to alter the insulin/glucagon ratio by glucose infusion after PH and study its relation to liver regeneration. cache = ./cache/cord-006391-esnsa4u5.txt txt = ./txt/cord-006391-esnsa4u5.txt === reduce.pl bib === id = cord-256015-tt58n0jk author = Zhu, Juanjuan title = Clinical characteristics and therapeutic procedure for a critical case of novel coronavirus pneumonia treated with glucocorticoids and non-invasive ventilator treatment date = 2020-06-01 pages = extension = .txt mime = text/plain words = 1344 sentences = 71 flesch = 52 summary = title: Clinical characteristics and therapeutic procedure for a critical case of novel coronavirus pneumonia treated with glucocorticoids and non-invasive ventilator treatment Herein, we report the clinical characteristics and diagnosis of a patient with severe NCP who was treated with glucocorticoids and non-invasive ventilation. The results indicated that the levels of IL-6 and C-reactive protein had decreased with the increase in the dosage and duration of methylprednisolone therapy and returned to normal on February 10. On the 19 th day of admission, a nasopharyngeal swab was performed for the first time after the treatment and the test result was negative for 2019-nCoV infection. In addition, the levels of IL-6 and C-reactive protein returned to normal on day 8 of methylprednisolone use. Glucocorticoids and non-invasive ventilator treatment could significantly improve the clinical symptoms in critically ill patients with NCP. cache = ./cache/cord-256015-tt58n0jk.txt txt = ./txt/cord-256015-tt58n0jk.txt === reduce.pl bib === id = cord-257654-8u9m1k5q author = Tschöpe, Carsten title = Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis date = 2020-07-14 pages = extension = .txt mime = text/plain words = 6281 sentences = 370 flesch = 43 summary = On the basis of the link between inflammation, fibrosis, aldosterone, and extracellular matrix regulation, we aimed to investigate the effect of an early intervention with the mineralocorticoid receptor antagonist (MRA) eplerenone on cardiac remodelling in a murine model of persistent coxsackievirus B3 (CVB3)‐induced myocarditis. 40 Because an uncontrolled early fulminant activated immune reaction together with aldosterone can trigger an irreversible cardiac damage with long-time consequences for cardiac remodelling and function in the post-inflammatory myocarditis phase, we sought to demonstrate whether an early intervention with the mineralocorticoid receptor antagonist (MRA) eplerenone (EPL) exerts cardio-beneficial effects to balance the inflammatory defence and healing reaction of the immune system in a murine model of persisting CVB3-induced myocarditis. However, no significant changes in nitrotyrosine staining were detected in any group at 28 days p.i. In vitro, EPL decreased the oxidative stress, depicted as DCF+ cells, in CVB3-infected HL-1 cardiomyocytes ( Figure 5E) . cache = ./cache/cord-257654-8u9m1k5q.txt txt = ./txt/cord-257654-8u9m1k5q.txt === reduce.pl bib === id = cord-266571-qbskh1uu author = de Arriba, M.L title = Lymphoproliferative responses and protection in conventional piglets inoculated orally with virulent or attenuated porcine epidemic diarrhoea virus date = 2002-06-04 pages = extension = .txt mime = text/plain words = 5103 sentences = 217 flesch = 42 summary = Lymphocyte proliferative responses were evaluated in mucosal (mesenteric lymph nodes) and systemic (spleen and blood) lymphoid tissues of conventional piglets inoculated with the virulent or attenuated isolates of porcine epidemic diarrhoea virus (PEDV) strain CV-777 and challenged 21 days later with the virulent isolate of the same virus. Virus-specific lymphoproliferative responses of systemic tissues (spleen and blood) and mesenteric lymph nodes were studied in conventional piglets after primary inoculation with the virulent, wild type, strain CV-777 of PEDV or its cell culture attenuated form and after challenge, 3 weeks later, with a high dose of the virulent virus. Correlations between lymphocyte proliferative responses in mononuclear cells collected from mesenteric lymph nodes, blood and spleen from pigs inoculated with virulent or attenuated PEDV or mock-inoculated and protection against challenge 21 days later with virulent PEDV. cache = ./cache/cord-266571-qbskh1uu.txt txt = ./txt/cord-266571-qbskh1uu.txt === reduce.pl bib === id = cord-005777-6rvfsx4p author = nan title = PS 0420-0716 date = 2007-08-25 pages = extension = .txt mime = text/plain words = 59217 sentences = 3634 flesch = 53 summary = We prospectively recorded data of all patients who were newly diagnosed with AF and all those with a septic shock on a surgical ICU (no cardiac surgery) during a one year period according to the requirements of the local ethical committee. Our aim was to evaluate the predictive role of admission APACHE II, admission and total maximum SOFA score, hypoalbuminemia, increased serum creatinine, C-reactive protein, lactate, and serum blood glucose for the 30-day mortality of septic patients admitted to medical ICU. The aim of this study was to analyze the clinical presentation and to evaluate mortality associated factors (timing and accurancy of diagnosis, timing of surgery, severity score and organ failure, surgical and medical treatments). Data were extracted independently to assess intention to treat intensive care unit (ICU) and hospital mortality, days of mechanical ventilation, length of stay, incidence of ventilator-associated pneumonia and pneumothorax, and associated complications of the implemented intervention. cache = ./cache/cord-005777-6rvfsx4p.txt txt = ./txt/cord-005777-6rvfsx4p.txt === reduce.pl bib === id = cord-280821-kc0ut4oy author = Venturini, Elisabetta title = Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease date = 2020-09-24 pages = extension = .txt mime = text/plain words = 5481 sentences = 315 flesch = 45 summary = The Italian Society of Pediatric Infectious Diseases steering and scientific committee developed a position paper on treatment of children with COVID-19, reviewing the current literature on this topic and providing indications based on the available literature data. Currently, American guidelines on COVID-19 treatment published in May 2020, recommend both in children and adults to use lopinavir/ritonavir only in the context of clinical trials, given the lack of effectiveness reported now in literature [9, 12] . The latest Chinese guidelines on SARS-Cov-2 pneumoniae do not recommend the use of a specific antiviral for the treatment of COVID-19, and nevertheless include lopinavir/ritonavir among the available therapeutic options for hospitalized patients [29] . In May 2020, following an assessment of the emergency use authorization criteria and available scientific evidence, the FDA issued an emergency use authorization allowing for the administration of remdesivir intravenously by health care providers for the treatment of COVID-19 suspected or laboratoryconfirmed in adults and pediatric patients hospitalized with severe disease [34] . cache = ./cache/cord-280821-kc0ut4oy.txt txt = ./txt/cord-280821-kc0ut4oy.txt === reduce.pl bib === id = cord-268341-103xf3dw author = Parra, Beatriz title = Kinetics of Cytokine mRNA Expression in the Central Nervous System Following Lethal and Nonlethal Coronavirus-Induced Acute Encephalomyelitis date = 1997-07-07 pages = extension = .txt mime = text/plain words = 5778 sentences = 316 flesch = 49 summary = the plaque size and pathogenesis similar to the parental During JHMV infection of the CNS there is an abrupt suckling mouse brain pool of JHMV originally described increase in mRNA encoding interleukin-1 (a and b), ILby Weiner (1973) and produces a lethal encephalomyeli-6, tumor necrosis factor (TNF)-a, and interferon (IFN)-g, tis with minimal demyelination apparent at the time of at the time of maximal decrease in virus replication and death. Similar of mice through Day 5 postinfection, consistent with the to the kinetics of IFN-g, TNF-a mRNA increased until rapid accumulation of both NK and T cells in the CNS of death of lethally infected mice. Similarly, the adoptive transfer at the time most lethally infected mice were about to succumb to infection (Day 7), there was no difference in the of virus-specific CD4 / T cells to JHMV-infected mice demonstrates that some clones protect via reducing viral peak levels of IL-10 mRNA between the two groups. cache = ./cache/cord-268341-103xf3dw.txt txt = ./txt/cord-268341-103xf3dw.txt === reduce.pl bib === id = cord-033791-q0wizf2n author = Kavirayani, Akhila title = The Lazarus effect of very high-dose intravenous anakinra in severe non-familial CNS-HLH date = 2020-10-15 pages = extension = .txt mime = text/plain words = 614 sentences = 50 flesch = 29 summary = title: The Lazarus effect of very high-dose intravenous anakinra in severe non-familial CNS-HLH Abbreviations: BAL -bronchoalveolar lavage, CRP -C-reactive protein, TRAPS -Tumour necrosis factor receptor-associated periodic syndrome, WCC -white cell count, FHL -Familial Haemophagocytic lymphohistiocytosis IV methyl prednisolone, 1 dose of IV Immunoglobulin, empiric antibiotics and antivirals-IV aciclovir and IV ceftriaxone, switched to meropenem/teicoplanin upon deterioration (doxycycline/clindamycin/co-amoxiclav also administered subsequently with co-trimoxazole/fluconazole prophylaxis) Inotropes for profound hypotension. Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis Benefit of Anakinra in Treating Pediatric Secondary Hemophagocytic Lymphohistiocytosis Successful treatment of severe paediatric rheumatic disease-associated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: case series with 12 patie nts Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome Therapeutic Role of Anakinra, an Interleukin-1 Receptor Antagonist, in the Management of Secondary Hemophagocytic Lymphohistiocytosis/Sepsis/Multiple Organ Dysfunction/Macrophage Activating Syndrome in Critically Ill Children*: Pediatric Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab: Alemtuzumab for Refractory HLH Pediatric CNS-isolated hemophagocytic lymphohistiocytosis cache = ./cache/cord-033791-q0wizf2n.txt txt = ./txt/cord-033791-q0wizf2n.txt === reduce.pl bib === id = cord-271180-cnrs0zpg author = Rizvi, Saniya title = Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? A case report. date = 2020-09-18 pages = extension = .txt mime = text/plain words = 3896 sentences = 220 flesch = 49 summary = CytosorbentsⓇ cytokine filter is a potential treatment methodology aimed at reducing the cytokine storm, thus serving as a bridge for therapy in the acutely ill patients infected with COVID-19. The following case report demonstrates the utility in a critically ill patient who survived the cytokine storm after receiving the cytokine filter via continuous renal replacement therapy bridging him to further definitive therapy. The following is a case report on a patient encounter and management course through the course of illness in which the Cytosorbents Ⓡ filter was used for his presentation of COVID-19 with severe ARDS, worsening renal dysfunction and evidence of evolving cytokine storm. Chest x-ray hospital day 16, 5 days after the initiation of cytokine filter when the patient developed worsening hypoxia and increased oxygen requirements as indicated in Table 2 below. cache = ./cache/cord-271180-cnrs0zpg.txt txt = ./txt/cord-271180-cnrs0zpg.txt === reduce.pl bib === id = cord-274497-tqceazdp author = N. Nuñez, Luis Fabian title = Molecular Characterization and Pathogenicity of Chicken Parvovirus (ChPV) in Specific Pathogen-Free Chicks Infected Experimentally date = 2020-07-25 pages = extension = .txt mime = text/plain words = 4123 sentences = 192 flesch = 47 summary = In the present work, the pathogenicity, viral tissue distribution and molecular characterization of ChPV in chicks from a strain isolated in Brazil were determined with a demonstration of Koch's postulates according to our previous description [21] . In the present work, the pathogenicity, viral tissue distribution and molecular characterization of ChPV in chicks from a strain isolated in Brazil were determined with a demonstration of Koch's postulates according to our previous description [21] . Experimental infections with isolated ChPV (ABU-P1) have demonstrated that the virus causes enteric diseases, resulting mainly in chickens with diarrhea, cloacal pasting, impaired growth, runting and stunting [32] . Lesions were previously described in commercial chicken flocks affected with RSS and reported by our own group [21] ; the duodenal loop presented the same features, demonstrating Koch's postulates in relation to ChPV and experimentally infected chickens. cache = ./cache/cord-274497-tqceazdp.txt txt = ./txt/cord-274497-tqceazdp.txt === reduce.pl bib === id = cord-006444-eq56zhtd author = nan title = Abstracts of oral presentations and posters date = 1993 pages = extension = .txt mime = text/plain words = 40668 sentences = 2121 flesch = 53 summary = The results from ongoing preclinical studies continue to confirm the broad spectrum of biological activities possessed by rhiL-1 1 in vitro and suggest this cytokine may be an effective agent in the treatment of myelosuppression associated with cancer chemotherapy and bone marrow transplantation. We performed a phase H trial to assess the ability of G-CSF -mobilized PBPC to rapidly and completely restore hemopeiesis after high dose chemotherapy in the absence of bone marrow infusions, with selection for PBPC-only infusions based on yield of granulocyte -macrophage colony -forming cells (GM-CFC) after G-CSF treatment. Our approach for high-dose (HD) chemotherapy is to first treat patients eligible for dose intensification with a standard dose chemotherapy (VIP: VP26 = etoposide: 500 mg/m 2, ifosfamide: 4 g/m 2, cis-platinum: 50 mg/m 2) followed by the application of colony stimulating factors (G-CSF, GM-CSF or IL-3 + GM-CSF) in order to combine a regimen with broad anti-tumor activity with the recruitment of peripheral blood progenitor cells (PBPCs). cache = ./cache/cord-006444-eq56zhtd.txt txt = ./txt/cord-006444-eq56zhtd.txt === reduce.pl bib === id = cord-023017-k6edtg58 author = nan title = AASLD Abstracts (pp. 282A–382A) date = 2006-02-10 pages = extension = .txt mime = text/plain words = 65796 sentences = 3553 flesch = 51 summary = 14/55 (25%) patients in AC who did not discontinue by week 24 received ribavirin dose reduction in comparison to 31/108 ( The clinical outcome in response to combination therapy for treatment of chronic hepatitis C virus (HCV) infection appears to be different for Caucasian versus African American patients. Over the period of combination therapy, most patients in which serum virus titers were reduced to non detectable levels had significant increases in T cell responses to HCV proteins. CHRONIC Background: Recent large prospective trials demonstrated that the combination therapy of interferon (1FN)-alphalribavirin significantly increased the ratio of a sustained virological response in patients with chronic hepatitis C in comparison with IFN monotherapy, especially in patients with high HCV-RNA titer and genotype lb. Results: Patients with chronic HCV infection showed higher MxA gene expression levels than healthy controls, indicating that hepatitis C virus induces IFN production. cache = ./cache/cord-023017-k6edtg58.txt txt = ./txt/cord-023017-k6edtg58.txt === reduce.pl bib === id = cord-033453-557obi3r author = Bretscher, Lorenzo title = COVID-19 and the Cross-Section of Equity Returns: Impact and Transmission date = 2020-09-24 pages = extension = .txt mime = text/plain words = 12205 sentences = 945 flesch = 67 summary = Using the first reported case of COVID-19 in a given U.S. county as the event day, we find that firms headquartered in an affected county experience, on average, a 27-bps lower return in the 10-day post-event window. The regression results show that the average daily return of a labor-intensive firm residing in a high intensity county is 1% lower in the 10-day post-event window. To this end, we use analysts' forecast data from the I/B/E/S database and document that the first reported coronavirus case results in downward revision of earnings estimates of firms located in the same county. Second, and related, a unique advantage of our natural experiment is that it allows us to examine the relative strength of various channels (specifically, the labor supply channel, the uncertainty channel, the government policy channel, and the cash flow news channel) through which the COVID-19 shock affects firm valuations. cache = ./cache/cord-033453-557obi3r.txt txt = ./txt/cord-033453-557obi3r.txt === reduce.pl bib === id = cord-265891-jmpterrj author = Eilersen, Andreas title = Cost–benefit of limited isolation and testing in COVID-19 mitigation date = 2020-10-29 pages = extension = .txt mime = text/plain words = 3925 sentences = 233 flesch = 56 summary = Therefore, we will here implement a crude form of contact tracing where we (1) close the workplaces of people who are tested positive for the disease, (2) isolate their regular social contacts for a limited period, and (3) keep symptomatic individuals in quarantine until they recover. If 10% efficiency is possible, corresponding to detecting about a third of infectious cases, then peak height could be reduced by a factor of almost three with to a 60% drop, if the probability of infected people being tested is only 10% per day of illness. In Fig. 4 , we show two possible scenarios where testing and contact tracing is implemented after a 30-day lockdown with a 75% reduction of the work and social spheres. Using reasonable COVID-19 infection parameters we find that the 1STQ strategy can contribute to epidemic mitigation, in the sense that it can reduce the peak number of infected individuals by about a factor of two even with a realistic testing rate of 10% per day of illness. cache = ./cache/cord-265891-jmpterrj.txt txt = ./txt/cord-265891-jmpterrj.txt === reduce.pl bib === id = cord-280242-2w2kl0uf author = Kaya, Yildiz title = Transient cortical blindness in COVID-19 pneumonia; a PRES-like syndrome: A case report date = 2020-04-28 pages = extension = .txt mime = text/plain words = 767 sentences = 57 flesch = 46 summary = It has been reported that, in addition to the respiratory tract infection symptoms, patients can also have neurologic signs and symptoms; like acute cerebrovascular disease, polyneuritis, encephalitis and encephalopathy 2. Brain magnetic resonance imaging (MRI) showed bilateral, especially left occipital, frontal cortical white matter and splenium of corpus callosum T2/Fluid-attenuated inversion recovery (FLAIR) hyperintensities and diffusion restriction in diffusion weighted imaging (DWI) (Figure 2 ) revealing vasogenic edema similar to posterior reversible leucoencephalopathy (PRES). Recent autopsy reports have revealed that, like many viral infections SARS-CoV-2 can cause brain tissue edema and partial neuronal degeneration [3] . Infectious toxic encephalopathy is a reversible brain dysfunction syndrome caused by systemic toxemia, metabolic disorders and hypoxia during the process of acute infection [4] . Although we could not determine the exact ethiology in our case, regulating the blood pressure controlling the vasogenic edema by corticosteroid treatment and controlling the virus related pneumonia have helped fort he recovery of our patient. cache = ./cache/cord-280242-2w2kl0uf.txt txt = ./txt/cord-280242-2w2kl0uf.txt === reduce.pl bib === id = cord-031315-p7jb4gf2 author = Kong, Qing title = Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial date = 2020-09-03 pages = extension = .txt mime = text/plain words = 8352 sentences = 471 flesch = 52 summary = title: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial The present study aims to evaluate the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations and to investigate whether the short-term (5-days) systemic glucocorticoid therapy is non-inferior to the long-term (9-day) regime. On one hand, a dose of 40 mg prednisone (a common oral systemic glucocorticoid) daily for 5 days has been recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Science Committee Report based on the REDUCE randomized clinical trial since 2015 [24] . We conducted a randomized and placebo-controlled trial enrolling stable COPD patients in 2014, which illustrated that TCM formulas called Bushen Yiqi (BY) formulas can improve the lung function, reduce the frequency of acute exacerbation of COPD, and modulate the HPA axis [35] . cache = ./cache/cord-031315-p7jb4gf2.txt txt = ./txt/cord-031315-p7jb4gf2.txt === reduce.pl bib === id = cord-015090-n6f4xupw author = nan title = PS 339-563 date = 2005-09-10 pages = extension = .txt mime = text/plain words = 26280 sentences = 1560 flesch = 53 summary = We designed this study to examine the effects of fiberoptic bronchoscopy (FOB) with and without BAL on body temperature, systemic arterial pressure, heart rate and supportive therapies requirements in mechanically ventilated patients. Clinical characteristics (Glasgow scale, heart rate, systolic blood pressure), cardiac enzymes (troponin I, total serum creatine kinase and myocardial isoenzyme, myoglobin), ECG changes (ST-T changes, prolonged QT and corrected QT intervals), echocardiographic assessment of cardiac function (left ventricular ejection fraction, hypokinesia) were studied on the day of the admission. It is a prospective study performed during 12 months of the patients with brain trauma admitted in a 24-beds medical-surgical ICU of a 650-beds university hospital. This prospective observational study included 200 adult patients admitted to a 31-bed university hospital medical-surgical ICU during a 3-month period. cache = ./cache/cord-015090-n6f4xupw.txt txt = ./txt/cord-015090-n6f4xupw.txt === reduce.pl bib === id = cord-283257-rh3bxvv7 author = Andrejčáková, Zuzana title = Synbiotics suppress the release of lactate dehydrogenase, promote non‐specific immunity and integrity of jejunum mucosa in piglets date = 2015-12-21 pages = extension = .txt mime = text/plain words = 4572 sentences = 234 flesch = 43 summary = The impact of such additives on the release of lactate dehydrogenase (LDH; spectroscopic and electrophoretic assay), alteration of immunity (index of metabolic activity), jejunum histology (light microscopy), and health of conventional piglets from a problematic breed (monitoring of hematology, consistency and moisture of feces and body temperature) were examined. We found significant decrease in LDH leakage in the blood serum and tissue extracts, indicating better cell membrane integrity in the individual organs of animals. The aim of our study therefore was to examine the effect of synbiotics through flaxseed feed supplementation in combination with Lactobacillus plantarum -Biocenol TM LP96 (CCM 7512) and Lactobacillus fermentum -Biocenol TM LF99 (CCM 7514), on the activity of lactate dehydrogenase (LDH), alteration of immunity, jejunum histology and health of conventional piglets from a problematic breed. cache = ./cache/cord-283257-rh3bxvv7.txt txt = ./txt/cord-283257-rh3bxvv7.txt === reduce.pl bib === id = cord-006344-de4dhv4b author = Seitsonen, E. title = Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection date = 2006-03-21 pages = extension = .txt mime = text/plain words = 2771 sentences = 174 flesch = 48 summary = title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection Reported here are two cases of hantavirus pulmonary syndrome caused by Puumala virus infection, which rapidly resolved after initiation of corticosteroid treatment combined with continuous veno-venous hemodiafiltration. We describe two cases of PUU-associated HPS, in which administration of intravenous corticosteroids combined with continuous veno-venous hemodiafiltration (CVVHDF) was followed by rapid clinical improvement. On day 5 POS the lung infiltrates had increased considerably (Fig. 3a,b) , and the patient required continuous ventilation with a positive airway pressure mask. We describe two cases of PUU-infected patients who presented with both renal and respiratory failure requiring renal replacement therapy and mechanical ventilation. High levels of cytokineproducing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome High levels of viremia in patients with the Hantavirus pulmonary syndrome cache = ./cache/cord-006344-de4dhv4b.txt txt = ./txt/cord-006344-de4dhv4b.txt === reduce.pl bib === id = cord-023100-0pqnsiid author = nan title = Abstract date = 2008-04-10 pages = extension = .txt mime = text/plain words = 244 sentences = 20 flesch = 65 summary = key: cord-023100-0pqnsiid authors: nan cord_uid: 0pqnsiid nan The dogs had mild diarrhoea from three to 11 days after inoculation, approximately at the same time as the virus was excreted in the faeces. Virus could be isolated from the tonsils on day 3, and then from small and large intestinal tissues up to 14 days after inoculation; it was also isolated from liver and lung tissue. Virus neutralising antibody was first detected on day 10. Specific anti-ccv IgM was first detected in plasma three days after inoculation and IgG on days 4 to 7. Small amounts of anti-ccv IgG, IgM and IgA were detected in duodenal secretions, but none in bile. Chronic relapsing (dysimmune) polyneuropathy: diagnosis and treatment Chronic relapsing polyradiculoneuritis in a cat Peripheral neuropathy in cats with inherited primary hyperchylomicronaemia The authors wish to thank Karen Wadewell and Denise Wigney for expert technical assistance, and Dr A. cache = ./cache/cord-023100-0pqnsiid.txt txt = ./txt/cord-023100-0pqnsiid.txt === reduce.pl bib === id = cord-274860-7ec2jcoq author = Salazar, Eric title = Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG date = 2020-11-04 pages = extension = .txt mime = text/plain words = 4738 sentences = 234 flesch = 47 summary = title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG We recently reported results from interim analysis of a propensity-score matched study suggesting that early treatment of COVID-19 patients with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG significantly decreases mortality. In the aggregate, the analysis confirms and extends our previous preliminary finding that transfusion of COVID-19 patients soon after hospitalization with high titer anti-spike protein RBD IgG present in convalescent plasma significantly reduces mortality. In our previous study, interim analysis revealed that, relative to matched controls, patients transfused with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG within 72 hrs of hospital admission had significantly reduced mortality at 28 days post-transfusion. The data confirm our previous findings that transfusion of patients soon after hospital admission with high titer anti-spike protein RBD IgG present in convalescent plasma significantly decreases mortality. cache = ./cache/cord-274860-7ec2jcoq.txt txt = ./txt/cord-274860-7ec2jcoq.txt === reduce.pl bib === id = cord-268081-ytx6sf3x author = Guionie, Olivier title = An experimental study of the survival of turkey coronavirus at room temperature and +4°C date = 2013-04-22 pages = extension = .txt mime = text/plain words = 4051 sentences = 195 flesch = 55 summary = As TCoV does not induce lesions in the embryo, virus replication in the jejunum and ileum of the embryos was detected 4 days post inoculation, using RNA extraction and a real-time reverse transcriptase-polymerase chain reaction based on the nucleocapsid gene. However, infectious virus was still detected after 20 days storage at the cooler temperatures, a finding that suggests prolonged survival of Fr TCoV and easier transmission between poultry farms in a cool environment are possible. The first duplicates harvested after different times of storage at the different temperatures were used to test for the presence of residual infectious virus in the sample by inoculating SPF embryonated turkey eggs as described above. However, when the same samples were inoculated into embryonated SPF turkey eggs, viral RNA was detected in the digestive tracts of the inoculated embryos after 0 days of storage (27.5 Ct), but not after 42 or 40 days ( 40 Ct) at room temperature or '48C, respectively. cache = ./cache/cord-268081-ytx6sf3x.txt txt = ./txt/cord-268081-ytx6sf3x.txt === reduce.pl bib === id = cord-007456-acbo4zs2 author = Thomas, L.H. title = Growth of Mycoplasma bovis in organ cultures of bovine foetal trachea and comparison with Mycoplasma dispar date = 2002-11-13 pages = extension = .txt mime = text/plain words = 2797 sentences = 142 flesch = 52 summary = authors: Thomas, L.H.; Howard, C.J.; Parsons, K.R.; Anger, H.S. title: Growth of Mycoplasma bovis in organ cultures of bovine foetal trachea and comparison with Mycoplasma dispar Inoculation of tracheal organ cultures from bovine foetuses with Mycoplasma bovis resulted in a loss of cellular structure of the lamina propria, followed 20–22 days later by lifting and detachment of overlying epithelium. Ciliary activity was undiminished for up to 18 days following inoculation and little or no cytopathic effect on the ciliated epithelium was seen in spite of the close proximity of large numbers of organisms. bovis had virtually no cytopathic effect on the ciliated epithelium for 18 days following inoculation in spite of large numbers of organisms infiltrating between the columnar epithelium, accumulating in the lamina propria and amassing in the region of the basement membrane (Fig. 3) . cache = ./cache/cord-007456-acbo4zs2.txt txt = ./txt/cord-007456-acbo4zs2.txt === reduce.pl bib === id = cord-018110-mcw4v13c author = Arnold, Andreas title = Inner Ear date = 2010 pages = extension = .txt mime = text/plain words = 15854 sentences = 980 flesch = 46 summary = In the case of partial or no remission, prednisolone treatment should be continued orally for 16 days together with gastric proton pump inhibitors and additional haemodilutive/haemorheological infusion therapy together with α-lipoic acid should be administered as described for high-frequency idiopathic sensorineural hearing loss. Acute tinnitus due to noise-induced damage or acoustic trauma of the inner ear, idiopathic sensorineural hearing loss (sudden deafness), acute attack of Ménière's disease, toxic labyrinthitis, rupture of the round window, perilymphatic fistula of the round or oval window, labyrinthine contusion or fractures of the temporal bone due to head trauma should be treated with a daily dose of 250-500 mg prednisolone intravenously on three consecutive days. cache = ./cache/cord-018110-mcw4v13c.txt txt = ./txt/cord-018110-mcw4v13c.txt === reduce.pl bib === id = cord-005816-i54q5gsu author = nan title = 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date = 2009-08-06 pages = extension = .txt mime = text/plain words = 83124 sentences = 5617 flesch = 53 summary = Several factors such as the initial lack of symptoms, a low diagnostic sensitivity of the CT (34% false negatives), and the nonoperative management of solid organ injuries, have contributed to a delayed diagnosis in one of every five patients in our series, but this has not led to a significant increase in septic complications in this group. Method: The demographic features, the treatments, the intensity of the illness and mortality rate of the 155 patients in Afyon Kocatepe University General Surgery clinic between the years 2006 Background: Enterocutaneous fistula continues to be a serious surgical problem. Introduction: In our previous study, we examined the treatment results of burn patients older than 45 years, and found a significant increase in mortality with increasing age groups. Methods: Data on emergency surgical cases and admissions to the surgical service over a 3-month period were collected and analyzed; this included patient demographics, referral sources, diagnosis, operation, and length of stay (LOS Conclusion: Emergency workload represents a significant part of the work for the general surgeons. cache = ./cache/cord-005816-i54q5gsu.txt txt = ./txt/cord-005816-i54q5gsu.txt === reduce.pl bib === id = cord-032806-o6p861ms author = Fenin, Audrey title = Very low birth weight infants receive full enteral nutrition within 2 postnatal weeks date = 2020-09-29 pages = extension = .txt mime = text/plain words = 3977 sentences = 180 flesch = 53 summary = STUDY DESIGN: Very low birth weight infant cohort admitted in the first postnatal day and categorized as either Epoch 1 or Epoch 2, 12 months before and after implementation of a revised feeding protocol were compared. Despite the lack of difference in 2-year outcomes including survival without moderate or severe neurodevelopmental disability in this trial [9] , neonatal care centers may still find benefit if more rapid advancement of enteral feeds is associated with two common quality indicators in neonatal care-early discontinuation of central venous lines (CVL) and shorter duration of parenteral nutrition (PN), while maintaining infant growth. Therefore, this cohort study, with a retrospective control, was performed with a primary aim to determine if infants were able to reach the full enteral nutrition goal and with secondary aims to determine whether this outcome was associated with changes in PN exposure, CVL days, or growth. cache = ./cache/cord-032806-o6p861ms.txt txt = ./txt/cord-032806-o6p861ms.txt === reduce.pl bib === id = cord-275427-00bwhaga author = Aydogdu, Ugur title = The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis date = 2019-11-30 pages = extension = .txt mime = text/plain words = 5218 sentences = 264 flesch = 56 summary = Abstract In this study, it was aimed to investigate the efficacy of chitosan oligosaccharide administrations in different doses of experimental infected lambs with Cryptosporidium parvum. As a result, in lambs with experimental cryptosporidiosis, chitosan oligosaccharide improved in clinical signs and stool character shorter than the positive control group and the administration of chitosan oligosaccharide at doses of 100, 500 and 1000 mg/kg for 7 days significantly reduced oocyst excretion but not enough to remove cryptosporidiosis completely. parvum in in vitro studies, we hypothesized that oral chitosan administration may be used in the treatment of lambs with experimentally cryptosporidiosis. The aim of this study was to determine the treatment efficacy of oral chitosan oligosaccharide in lambs with experimental cryptosporidiosis. According to the findings of this study, the use of chitosan oligosaccharide to be used in the treatment of experimental cryptosporidiosis at doses of 100 and/or 500 mg/kg was found to provide an earlier reduction in oocyst excretion compared to 1000 mg/kg dose. cache = ./cache/cord-275427-00bwhaga.txt txt = ./txt/cord-275427-00bwhaga.txt === reduce.pl bib === id = cord-285096-g9y3au1a author = Mitchell, Judy A. title = Tropism and pathological findings associated with canine respiratory coronavirus (CRCoV) date = 2013-03-23 pages = extension = .txt mime = text/plain words = 7120 sentences = 340 flesch = 50 summary = Following experimental infection in dogs, all five CRCoV isolates gave rise to clinical signs of respiratory disease consistent with that observed during natural infection. Following experimental infection in dogs, all five CRCoV isolates gave rise to clinical signs of respiratory disease consistent with that observed during natural infection. In that study we demonstrated that young dogs were susceptible to experimental infection with both CRCoV isolates, which gave rise to clinical signs of respiratory disease consistent with naturally occurring infection. Analyses specifically focused on the histopathological changes in the canine upper and lower respiratory tissues, virulence differences among CRCoV isolates derived from CIRD cases representing wide geographical locations; UK and USA [MO, NE, UT and MI] , and the demonstration of Koch's postulates. Consistent with observations made during naturally occurring infection, dogs in this study also displayed clinical signs of mild respiratory disease following viral challenge (nasal discharge, sneezing, and coughing); whilst the control group remained healthy. cache = ./cache/cord-285096-g9y3au1a.txt txt = ./txt/cord-285096-g9y3au1a.txt === reduce.pl bib === id = cord-276338-wpo1eyeg author = Hesse, Amke title = In toxic demyelination oligodendroglial cell death occurs early and is FAS independent date = 2009-10-22 pages = extension = .txt mime = text/plain words = 5481 sentences = 288 flesch = 48 summary = During the initial phase of the cuprizone diet (days 6 and 10), but not during later stages (day 21), activated caspase 3 can be detected in apoptotic oligodendrocytes, suggesting that caspase 3-independent pathways trigger oligodendroglial cell death in later stages. In line with the notion of continuous oligodendroglial cell death, we found a significant decrease in the number of Nogo-A-positive mature oligodendrocytes in mice fed with cuprizone after 10 (540 ± 187 cells/mm 2 ) and 21 days (17 ± 15 cells/mm 2 ) compared to untreated controls (1797 ± 404 cells/mm 2 ) (Fig. 2b) . The number of apoptotic cells, Nogo-A-positive oligodendrocytes, activated caspase 3-expressing oligodendrocytes, macrophages and astrocytes, as well as the extent of demyelination, was determined on days 4, 6 and 10 and in mice fed with a cuprizone-free diet (controls). In the cuprizone model, apoptotic oligodendrocytes express activated caspase 3, and this is associated with a significant increase of FAS mRNA in the corpus callosum. cache = ./cache/cord-276338-wpo1eyeg.txt txt = ./txt/cord-276338-wpo1eyeg.txt === reduce.pl bib === id = cord-266156-xmf4emln author = Miller, Tyler E. title = Clinical sensitivity and interpretation of PCR and serological COVID‐19 diagnostics for patients presenting to the hospital date = 2020-08-28 pages = extension = .txt mime = text/plain words = 4329 sentences = 221 flesch = 45 summary = Our goal was to examine the clinical sensitivity of two most common SARS‐CoV‐2 diagnostic test modalities, polymerase chain reaction (PCR) and serology, over the disease course to provide insight into their clinical interpretation in patients presenting to the hospital. The goal of this study is to examine the clinical sensitivity and provide insights into the interpretation of the two most common SARS-CoV-2 diagnostic test modalities: polymerase chain reaction (PCR) and serology. Serologic analysis of IgM, IgA and IgG status was performed in a subset of the above SARS-CoV-2 PCR-positive patients for which we had excess material in the MGH core laboratories for clinical validation studies. To assess the sensitivity of our serology assay over time, we tested for IgM, IgG, and IgA antibodies against the RBD of SARS-CoV-2 spike protein in 157 SARS-CoV-2 PCR-positive patients using an in-house ELISA (Table 1) . cache = ./cache/cord-266156-xmf4emln.txt txt = ./txt/cord-266156-xmf4emln.txt === reduce.pl bib === id = cord-258696-01wj76es author = Decaro, Nicola title = Experimental infection of dogs with a novel strain of canine coronavirus causing systemic disease and lymphopenia date = 2008-04-30 pages = extension = .txt mime = text/plain words = 3428 sentences = 177 flesch = 61 summary = The dogs, three 2.5-month-old and two 6-month-old pups, were successfully infected, shedding viral RNA with their faeces for the entire observation period (21 days) and displaying systemic clinical signs resembling those observed during the course of natural infection. At postmortem examination, remarkable lesions were observed in the internal organs of the euthanized pups, that tested positive for CCoV by real-time RT-PCR and virus isolation on cell cultures. Unexpectedly, CCoV type II RNA was detected at very high titres in the internal organs of the dead pups and the virus (strain CB/05) was isolated on canine cell cultures. (last day of observation) reaching the maximal mean value of 6.79 Â 10 5 RNA copy numbers/ml of template at day 10 p.i. Surprisingly, CCoV RNA was never detected in the blood of the 6-month-old pups, as well as in the euthanized animals, in whose organs remarkable viral RNA titres were found. cache = ./cache/cord-258696-01wj76es.txt txt = ./txt/cord-258696-01wj76es.txt === reduce.pl bib === id = cord-021555-rrverrsj author = Delano, Margaret L. title = Biology and Diseases of Ruminants: Sheep, Goats, and Cattle date = 2007-09-02 pages = extension = .txt mime = text/plain words = 71765 sentences = 5075 flesch = 49 summary = These references also provide information regarding vaccination products licensed for use in ruminants and typical herd and flock vaccination parasite control schedules ("Current Veterinary Therapy," 1986 , 1999 "Council report," 1994; "Large Animal Internal Medicine," 1996; Smith and Sherman, 1994) When designing a vaccination program during qualification of a source or at the research facility, it is important to evaluate the local disease incidence and the potential for exposure. Clinical signs in chronic cases in older animals, such as adult goats, include soft stools, weight loss, anorexia, depression, and severe diarrhea, sometimes with mucus and blood. This pathogen does present a complication due to the carrier status of some animals, the likelihood of herd outbreaks, the severity of disease in younger animals, and the morbidity, possible progression to uveitis, and time and treatment costs associated with infections. cache = ./cache/cord-021555-rrverrsj.txt txt = ./txt/cord-021555-rrverrsj.txt === reduce.pl bib === id = cord-022659-chwk2bs4 author = nan title = Abstracts: Poster session date = 2004-10-08 pages = extension = .txt mime = text/plain words = 49153 sentences = 2598 flesch = 49 summary = We investigated the usefulness of informant-based data in Alzheimer's disease (AD) by comparing caregivers' subjective evaluations of 83 probable A D patients' performance on an abbreviated version of the Memory Self-Report Questionnaire to objective evaluations derived from an extensive battery of neuropsychological tests and to clinicians' evaluations. Compared with 89 subjects (mean age 75.2 yr; 34 men, 55 women) with dementia of the Alzheimer type (DAT), there were no significant group differences for comparable Clinical Dementia Rating stages of dementia for measures of language, Activities of Daily Living, or general cognition. The mean age at onset did not differ significantly between handedness groups (F [ l,lOO] = .82), but the mean duration of symptoms ( Alterations in the optical properties of brain can be used to detect pathological changes in patients with Alzheimer's disease (AD). cache = ./cache/cord-022659-chwk2bs4.txt txt = ./txt/cord-022659-chwk2bs4.txt === reduce.pl bib === id = cord-288051-wp8v2mc5 author = Sánchez-González, Álvaro title = What Should Be Known by a Urologist About the Medical Management of COVID-19’s Patients? date = 2020-09-01 pages = extension = .txt mime = text/plain words = 3616 sentences = 267 flesch = 47 summary = Seven days after the clinical onset, the risk of transmission decreases in mildsymptomatic patients, but it may be extended over 24 days in severe cases [11•, 15] . The clinical spectrum of SARS-CoV-2 infection varies widely, including asymptomatic infection, mild upper respiratory tract illness, severe viral pneumonia with respiratory failure, and even death [9, 11•] (Fig. 1) . Corticosteroids are recommended in the treatment of septic shock, exacerbation of chronic obstructive respiratory disease and these COVID-19's patients with respiratory deterioration and quick radiological progression associated with sings of cytokine storm (cytopenia, maintained fever, an increase of inflammatory reactants: D-dimer > 1000 ng/mL, ferritin > 1000 ng/mL, fibrinogen > 100 ng/mL, IL-6 > 40 pg/mL) [6, 23••] . Results from 237 patients, 158 assigned to remdesivir, showed no differences in time to clinical improvement, 28day mortality, oxygen support, hospitalization, or viral load. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Effective treatment of severe COVID-19 patients with tocilizumab cache = ./cache/cord-288051-wp8v2mc5.txt txt = ./txt/cord-288051-wp8v2mc5.txt === reduce.pl bib === id = cord-292970-32mql9nq author = Camdessanche, Jean-Philippe title = COVID-19 may induce Guillain-Barré syndrome date = 2020-04-15 pages = extension = .txt mime = text/plain words = 299 sentences = 24 flesch = 66 summary = key: cord-292970-32mql9nq title: COVID-19 may induce Guillain-Barré syndrome journal: Rev Neurol (Paris) DOI: 10.1016/j.neurol.2020.04.003 cord_uid: 32mql9nq In the context of COVID-19 pandemic, SARS-CoV-2 RT-PCR on nasopharyngeal swab was performed and positive. Clinical presentation was moderate with high grade fever for three days requiring oxygen 2-3 L/min through nasal cannula for five days. Eleven days after the symptom onset, while he did not need oxygen anymore having had no fever for five days, the patient complained of paresthesia in feet and hands. In three days, he Covid-19 pandemic is a worldwide disaster. Pulmonary disorder and respiratory insufficiency are the main problems linked to SARS-CoV-2 infection, which explains difficulties in ICU to treat numerous patients [2] . questioned the link between COVID-19 and GBS [3] . Our case is the first GBS with a chronology undoubtedly in favor of a complication of COVID-19 infection. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? cache = ./cache/cord-292970-32mql9nq.txt txt = ./txt/cord-292970-32mql9nq.txt === reduce.pl bib === id = cord-275889-4qwp3um1 author = Guarnieri, M. title = Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats date = 2017-04-09 pages = extension = .txt mime = text/plain words = 6861 sentences = 354 flesch = 55 summary = The intended label dose of 0.65 mg/kg, which provides 2-3 days of clinically significant blood levels of drug, was established in bioequivalence trials and efficacy studies to be described using male and female rats. In the single-dose phase of the trials, 4 groups of 8 rats (4 male, 4 female) were dosed after surgery (described below) with 0.0 (vehicle control), 1.3 (2x), 3.9 (6x), or 6.5 (10x) mg/kg drug suspension of buprenorphine on day 0. In the repeat-dose trials, 4 groups of 8 rats (4 male, 4 female) were dosed after surgery with the vehicle control or drug suspensions containing 1.3, 3.9, or 6.5 mg/kg of buprenorphine on day 0 and following anesthesia on days 4 and 8. Male and female rats were provided with a single dose of drug and sampled at time intervals from 8 hours to 9 days to measure blood concentrations of buprenorphine. cache = ./cache/cord-275889-4qwp3um1.txt txt = ./txt/cord-275889-4qwp3um1.txt === reduce.pl bib === id = cord-278224-sq7tokbx author = Protopopova, Alexandra title = Behavioral predictors of subsequent respiratory illness signs in dogs admitted to an animal shelter date = 2019-10-23 pages = extension = .txt mime = text/plain words = 7588 sentences = 391 flesch = 48 summary = Therefore, the aim of the study was to explore whether behavior at intake can predict subsequent occurrence and progression of upper respiratory disease in dogs at animal shelters. At the time of the study, the animal shelter had poor disease management practices, including poor sanitation, poor medical care, no vaccination at-intake, overcrowding, and continuous rotation of dogs in the kennels. This short observation period was previously used to detect behavioral differences across kenneled dogs in the animal shelter environment [28, 29] . To evaluate whether the latent temperament variables were associated with health, we proposed a basic structural model in which Curiosity, Sociability, Anxiety, Activity, and Time in the Shelter independently predicted Illness (Fig 1) . To evaluate whether Activity, Sociability, Anxiety, Curiosity, and Time in the shelter were related to the illness score, we conducted a basic PLS Path regression model in which our 5 latent variables were tested for association with illness. cache = ./cache/cord-278224-sq7tokbx.txt txt = ./txt/cord-278224-sq7tokbx.txt === reduce.pl bib === id = cord-006856-b1w25ob5 author = nan title = 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date = 2005 pages = extension = .txt mime = text/plain words = 29625 sentences = 1983 flesch = 52 summary = Egr-1 and hypoxia-inducible factor-1 (HIF-1) gene expression was examined in left ventricular biopsies of explanted failing hearts in 28 ICM and 42 DCM patients, as well as in 12 donor grafts before reperfusion (control), at 10, 30, 60 minutes after reperfusion, and at 1, 2, 3, 4, 6, 12 posttransplant weeks, using real-time RT-PCR. The risk of transplant-related mortality (TRM) due to graft-versushost disease (GvHD) is higher in male recipients of female stem cells compared with female patients receiving a graft from a female donor. We therefore analyzed a single-center cohort of 72 high-risk patients transplanted with a related or unrelated stem cell graft after nonmyeloablative conditioning for outcome (acute and chronic GvHD, TRM, relapse, and survival). Four patients between the age of 34 and 44 years underwent allogeneic peripheral blood stem cell (PBSC) transplantation (SCT) from HLA-identical sibling or unrelated donors at our institution. cache = ./cache/cord-006856-b1w25ob5.txt txt = ./txt/cord-006856-b1w25ob5.txt === reduce.pl bib === id = cord-287182-f0q8gfzc author = Liao, Ji‐ping title = Severe pneumonia caused by adenovirus 7 in pregnant woman: Case report and review of the literature date = 2016-06-21 pages = extension = .txt mime = text/plain words = 2078 sentences = 131 flesch = 49 summary = title: Severe pneumonia caused by adenovirus 7 in pregnant woman: Case report and review of the literature We report a rare case of adenoviral pneumonia in a previously healthy pregnant woman at 26(+4) weeks' gestation. Here, we report a case of severe communityacquired adenoviral pneumonia in a previously healthy pregnant woman who was managed successfully. 5 Previous studies have shown that pregnant women with viral pneumonia, such as influenza A virus subtype H1N1 and severe acute respiratory syndrome (SARS) coronavirus, have a higher mortality rate and higher rates of both intubation and intensive care unit admission than the general population. 1 In addition, increased adverse pregnancy outcomes, such as preterm delivery, low-birthweight infants, spontaneous abortion and fetal death, are higher in pregnant patients with H1N1 pneumonia than those without. A case-controlled study comparing clinical course and outcomes of pregnant and nonpregnant women with severe acute respiratory syndrome cache = ./cache/cord-287182-f0q8gfzc.txt txt = ./txt/cord-287182-f0q8gfzc.txt === reduce.pl bib === id = cord-287520-51kmd2ds author = Carneiro, Arie title = Impact of the COVID-19 Pandemic on the Urologist’s clinical practice in Brazil: a management guideline proposal for low- and middle-income countries during the crisis period date = 2020-05-20 pages = extension = .txt mime = text/plain words = 4537 sentences = 282 flesch = 49 summary = Therefore, most worldwide authorities are recommending to avoid, as much as possible, patient's elective visits to hospitals, as well as a judicious use of the operating room in order to mitigate the strain put on the health system. If it is not possible to separate an entire surgical block, we suggest designating specific rooms for the care of patients with COVID-19 that will not be used for regular cases. The gold standard test for investigation of the upper urinary tract is uro-tomography, but in times when we need to consider the use of resources, ultrasound could potentially be used since many imaging services are overloaded due to the frequent indication of thoracic CTs for the diagnosis and follow-up of patients with Sars-Cov-2. -In Intermediate-risk and high-risk non--muscle-invasive bladder cancers: Clinically fit patients with no major comorbidities should receive induction therapy followed by at least 1-year maintenance BCG. cache = ./cache/cord-287520-51kmd2ds.txt txt = ./txt/cord-287520-51kmd2ds.txt === reduce.pl bib === id = cord-282158-08u3x1z4 author = Yang, William H. title = Long-term immunogenicity of an AS03-adjuvanted influenza A(H1N1)pdm09 vaccine in young and elderly adults: An observer-blind, randomized trial() date = 2013-09-13 pages = extension = .txt mime = text/plain words = 5295 sentences = 252 flesch = 49 summary = This large-scale, randomized study in subjects ≥18 years of age assessed whether one dose of AS03-adjuvanted 3.75 g HA influenza A(H1N1)pdm09 vaccine elicited immune response that met the US and European regulatory criteria. A single dose of the AS03-adjuvanted 3.75 g HA influenza A(H1N1)pdm09 vaccine elicited HI immune responses in the 18-64 years and >64 years age groups that met the CBER regulatory criteria at Day 21 ( Table 1 ). At Day 21, a single dose of the non-adjuvanted 15 g HA influenza A(H1N1)pdm09 vaccine elicited HI immune responses in subjects 18-64 years and >64 years of age that met the CBER regulatory criteria (Table 1) . Data from this large, controlled study in adults 18 years of age and older demonstrated that a single dose of AS03-adjuvanted or non-adjuvanted influenza A(H1N1)pdm09 vaccine elicited strong HI immune responses 21 days later that met the CHMP and the more stringent CBER criteria for pandemic influenza vaccines. cache = ./cache/cord-282158-08u3x1z4.txt txt = ./txt/cord-282158-08u3x1z4.txt === reduce.pl bib === id = cord-291315-y40s45iv author = Logunov, Denis Y title = Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia date = 2020-09-04 pages = extension = .txt mime = text/plain words = 5697 sentences = 282 flesch = 50 summary = title: Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia Primary outcome measures were antigen-specific humoral immunity (SARS-CoV-2-specific antibodies measured by ELISA on days 0, 14, 21, 28, and 42) and safety (number of participants with adverse events monitored throughout the study). INTERPRETATION: The heterologous rAd26 and rAd5 vector-based COVID-19 vaccine has a good safety profile and induced strong humoral and cellular immune responses in participants. These findings of two open, phase 1/2 non-randomised studies of a heterologous prime-boost COVID-19 vaccine based on recombinant adenoviral vectors rAd26-S and rAd5-S show that the vaccine is safe, well tolerated, and induces strong humoral and cellular immune responses in 100% of healthy participants. In our study, despite formation of neutralising antibodies to recombinant adenoviruses after vaccination with rAd26 and rAd5, formation of a humoral immune response to target antigen (SARS-CoV-2 glycoprotein S) in vaccinated volunteers was not affected. cache = ./cache/cord-291315-y40s45iv.txt txt = ./txt/cord-291315-y40s45iv.txt === reduce.pl bib === id = cord-295086-tc3re52f author = Lu, Guoguang title = Dynamic changes in routine blood parameters of a severe COVID-19 case date = 2020-05-13 pages = extension = .txt mime = text/plain words = 1749 sentences = 82 flesch = 49 summary = METHODS: We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days. RESULTS: Our study found that the patient's condition worsened in the first week after admission; white blood cells (WBCs), neutrophils, lymphocytes, monocytes, eosinophils, erythrocytes, hemoglobin, neutrophil lymphocyte ratio (NLR), platelets (PLT) and platelet lymphocyte ratio (PLR) decreased. The number of WBCs, neutrophils, monocytes, eosinophils and lymphocytes increased gradually, and the erythrocyte parameters stopped declining and stabilized in a certain range; CRP decreased rapidly. On the 20th day of admission, the nucleic acid test was negative, WBC, neutrophil, CRP, NLR and PLR decreased gradually, and monocyte, lymphocyte, and eosinophil counts increased. In addition, it should be noted that monocytes and eosinophils were extremely low within 10 days after admission, which might indicate that the patient's condition was serious, and then gradually recovered to normal. cache = ./cache/cord-295086-tc3re52f.txt txt = ./txt/cord-295086-tc3re52f.txt === reduce.pl bib === id = cord-277077-kwaiorp8 author = Tița, Ovidiu title = Use of Yoghurt Enhanced with Volatile Plant Oils Encapsulated in Sodium Alginate to Increase the Human Body’s Immunity in the Present Fight Against Stress date = 2020-10-19 pages = extension = .txt mime = text/plain words = 8103 sentences = 433 flesch = 58 summary = The main purpose of this paper is to create a yoghurt with high antioxidant capacity, using only raw materials from Romania; (2) Methods: The bioactive components used to enrich the cow milk yoghurt were extracted as volatile oils out of four aromatic plants: basil, mint, lavender and fennel. The 2,2-diphenyl-1-picrylhy-drazyl (DPPH) method was used to determine the antioxidant activity; (3) Results: The results show that cow milk yoghurt enhanced with volatile oils of basil, lavender, mint and fennel, encapsulated in sodium alginate has an antioxidant and antimicrobial effect as a staple food with multiple effects in increasing the body's immunity. The antioxidant and antimicrobial activity of volatile fennel oil is offered by the high content of trans-anethole (63.30%), pinene (11.11%) and fenchone (8.32%) [20] [21] [22] [23] [24] [25] Basil (Ocimum basilicum) is an aromatic plant that belongs to the Lamiaceae family and is considered a rich source of essential oils. cache = ./cache/cord-277077-kwaiorp8.txt txt = ./txt/cord-277077-kwaiorp8.txt === reduce.pl bib === id = cord-282268-f7mbdfr6 author = Cartenì, Armando title = How mobility habits influenced the spread of the COVID-19 pandemic: Results from the Italian case study date = 2020-06-24 pages = extension = .txt mime = text/plain words = 5276 sentences = 209 flesch = 48 summary = By contrast, the hypothesis discussed in this research is that the time period (days) in which a new positive case of coronavirus is identified and certified, which could be called a sort of a positivity detection time, is longer than the incubation time because of possible delays between contagion and detection caused, for example, by the significant percentage of tests that prove false negative to COVID-19, or by the fraction of people who, although infected, are asymptomatic and/or initially show only mild symptoms, and therefore do not resort to health care. Estimates were made through a multiple linear regression model linking the number of certified daily cases (day-to-day) to socio-economic indices (e.g. number of residents; population density), environmental variables (e.g. temperature, PM pollution), health care indicators (e.g. number of swabs taken daily) and mobility habits (e.g. number people who performed trips several days before). cache = ./cache/cord-282268-f7mbdfr6.txt txt = ./txt/cord-282268-f7mbdfr6.txt === reduce.pl bib === id = cord-295367-xhdki8jn author = McNally, D. title = Rapid relief of acute sore throat with AMC/DCBA throat lozenges: randomised controlled trial date = 2009-10-22 pages = extension = .txt mime = text/plain words = 7328 sentences = 336 flesch = 57 summary = The superior analgesic effects and improvements in functional impairment scores observed with AMC/DCBA throat lozenges translate into pain relief benefits that are clinically meaningful and are thus a suitable OTC treatment option for patients in the self‐management of acute sore throat. The superior analgesic effects and improvements in functional impairment scores observed with AMC ⁄ DCBA throat lozenges translate into pain relief benefits that are clinically meaningful and are thus a suitable OTC treatment option for patients in the self-management of acute sore throat. The primary objective of this study was to determine the analgesic properties of AMC ⁄ DCBA throat lozenges compared with non-medicated lozenges, in patients with sore throat because of URTIs. The secondary objectives were to determine any additional patient benefits provided by active lozenges compared with placebo lozenges, including the effects on functional impairment scores and the type of relief experienced within the mouth. cache = ./cache/cord-295367-xhdki8jn.txt txt = ./txt/cord-295367-xhdki8jn.txt === reduce.pl bib === id = cord-007064-nepgttxf author = Chemaly, Roy F title = A Phase II, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients date = 2019-12-03 pages = extension = .txt mime = text/plain words = 5033 sentences = 227 flesch = 42 summary = title: A Phase II, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients This is the largest randomized, double blind, placebo-controlled clinical trial to date for the treatment of allogeneic and autologous HCT recipients with RSV URTIs. Presatovir treatment did not meet the coprimary endpoints of a greater time-weighted average change in the RSV viral load from Day 1 to 9 and the reduced development of LRTCs through Day 28, but was well tolerated, with a comparable safety profile relative to the placebo. In a post hoc analysis of patients with lymphopenia, the proportion who developed an LRTC through Day 28 was 51% lower following treatment with presatovir, as compared to the placebo; other post hoc analyses also indicated trends toward a treatment effect on LRTCs. The results suggest lessons for the design of future clinical trials of drugs for RSV or other respiratory viruses in transplant recipients or other immunocompromised patients. cache = ./cache/cord-007064-nepgttxf.txt txt = ./txt/cord-007064-nepgttxf.txt === reduce.pl bib === id = cord-005646-xhx9pzhj author = nan title = 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date = 1996 pages = extension = .txt mime = text/plain words = 72031 sentences = 4734 flesch = 56 summary = Aims and methods The aim of both a prospective and retrospective survey conducted in German pediatric intensive care units in 1993 was to accumulate data on the epidemiology, risk factors, natural history and treatment strategies in a large group of pediatric ARDS patients who were treated in the tt~ee year period from 1991 to 1993.All patients had acute bilateral alveolar infiltration of noncardiogenic origin and a pO2~iO2 ratio < 150mmHg. The influence of sex, underlying disease and single organ failure was analyzed using the Fischer's exact test, the influence of additional organ failure on mortality was tested with the Cochran-Mantel-Haenszet statistics. cache = ./cache/cord-005646-xhx9pzhj.txt txt = ./txt/cord-005646-xhx9pzhj.txt === reduce.pl bib === id = cord-014538-6a2pviol author = Kamilia, Chtara title = Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date = 2017-01-10 pages = extension = .txt mime = text/plain words = 61068 sentences = 3463 flesch = 49 summary = Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). cache = ./cache/cord-014538-6a2pviol.txt txt = ./txt/cord-014538-6a2pviol.txt === reduce.pl bib === id = cord-015126-cyhcbk1j author = nan title = PS 0036-0344 date = 2007-08-25 pages = extension = .txt mime = text/plain words = 59175 sentences = 3672 flesch = 54 summary = We compared them with ≥70 years old and an ICU stay < 30 days patients, the differences in ICU mortality, Apache II, age, gender and the necessity for renal replacement therapy (RRT) were not significant (see table) . The patients with mild form of acute pancreatitis had low mortality rate (similar to general ward population) despite positive ICU admission criteria in our case series with fifty per cent development of severe form with organ dysfunction/failure later on. Collected data:Demographics,Management prior and during ICU hospitalization (sedation, catecolamin drug use, blood product transfusion, intra-cranial pressure monitoring, neurosurgical emergency surgery etc.),CT-Scan results, Daily worst Glasgow coma scale, admission Simplified Acute Physiology Score II. This prospective interventional study performed in a surgical Intensive Care Unit of a tertiary University Hospital included 35 (21 males) mechanically ventilated and sedated patients with acute cardiovascular failure requiring cardiac output measurement (transpulmonary thermodilution technique)and a fluid challenge. cache = ./cache/cord-015126-cyhcbk1j.txt txt = ./txt/cord-015126-cyhcbk1j.txt === reduce.pl bib === id = cord-005478-5iu38pr6 author = nan title = The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session date = 2019-07-03 pages = extension = .txt mime = text/plain words = 63350 sentences = 3869 flesch = 58 summary = There were some differences among groups: patients in group-1 were younger (median age 46 years, p< 0.02) were transplanted in more recent year (2015, p< 0.001), received more frequently a regimen based on TBF (thiotepa, fludarabine and busulfan) (83%, p< 0.001) and bone marrow (BM) as source of stem cells (77%, p< 0.001), with no ATG (100%, p< 0.001). Clinical Trial Registry: NCT01217723 Disclosure: None of the Authors have any conflicts of interest to declare O105 Immune reconstitution -based score at diagnosis of CGVHD predicts GVHD severity and overall-survival: A novel prognostication tool for GVHD treatment tailoring Background: Allogeneic stem cell transplantation (HSCT) survivors are at a relevant risk of developing chronic GvHD (cGvHD), which importantly affects quality of life and increases morbidity and mortality. cache = ./cache/cord-005478-5iu38pr6.txt txt = ./txt/cord-005478-5iu38pr6.txt === reduce.pl bib === id = cord-285812-l7dpv6nx author = O’TOOLE, D. title = Pathogenicity of experimental infection with ‘pneumotropic’ porcine coronavirus date = 1989-07-31 pages = extension = .txt mime = text/plain words = 3072 sentences = 163 flesch = 45 summary = Virus localisation and lesions were studied in 14 one-week-old piglets following combined intranasal-oral inoculation with a British isolate of 'pneumotropic' porcine coronavirus (pcv) and were compared with the effects of transmissible gastroenteritis virus (tgev) infection in five piglets. Virus localisation and lesions were studied in 14 oneweek-old piglets following combined intranasal-oral inoculation with a British isolate of 'pneumotropic' porcine coronavirus (pcv) and were compared with the effects of transmissible gastroenteritis virus (TGEV) infection in five piglets. Following sterilisation of cages and isolators, a second batch of 12 piglets (Large White cross Landrace) aged seven days from two litters were inoculated with rev (five) or TGEV (five) or were uninoculated controls (two). Between two and six days after infection, acute changes were characterised by individual bronchiolar cells bulging into the lumen, ..; 00I'm Immunocytochemistry r-ev antigen was identified in the epithelial cytoplasm of small and medium bronchioles in eight of 14 piglets and its distribution was closely correlated with areas of pneumonia. cache = ./cache/cord-285812-l7dpv6nx.txt txt = ./txt/cord-285812-l7dpv6nx.txt === reduce.pl bib === id = cord-015024-2xzc0uc5 author = nan title = ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date = 2010-08-31 pages = extension = .txt mime = text/plain words = 84393 sentences = 5234 flesch = 52 summary = We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). cache = ./cache/cord-015024-2xzc0uc5.txt txt = ./txt/cord-015024-2xzc0uc5.txt === reduce.pl bib === id = cord-015369-72cjogxz author = nan title = 50th Annual Meeting of the Austrian Society of Surgery. Vienna, June 18–20, 2009. Guest Editors: Albert Tuchmann, Erhard Schwanzer, Benedikt Walzel date = 2009 pages = extension = .txt mime = text/plain words = 71071 sentences = 7094 flesch = 50 summary = Bei 2 Patienten wurde wegen eines Rezidivs eine neuerliche RFT mit liver packing notwendig, 5 Patienten wurden ohne Packing ein zweites mal abladiert und ein Patient unterzog sich einer linksseitigen Hemihepatektomie nach rechtsseitiger Ablation. Das laparoskopische Liver Packing ermöglicht eine ablative Therapie der Leber in Patienten, die mit den herkömmlichen Möglichkeiten nicht lokal therapierbar sind. Zusammenfassend lässt sich anhand der hier vorliegenden Studie zeigen, dass die Therapie von VSM mittels ELT mit 1470-nm-Diodenlaser und Radialfaser eine sowohl minimalinvasive als auch sichere und effiziente Therapieoption darstellt und eine hohe frühzeitige Erfolgsrate bei niedrigem Schmerzniveau aufweist.In weiteren Studien muss geprueft werden, ob aehnlich gute Resultate auch bei weiterer Absenkung des Energienivaus zu erreichen sind. Patients who underwent R0 resection for colon and rectal cancer during the period 1995-2000 showed a significantly improved 5-year survival rate compared to those operated on between 1991 and 1995. cache = ./cache/cord-015369-72cjogxz.txt txt = ./txt/cord-015369-72cjogxz.txt === reduce.pl bib === id = cord-006182-kck5e1ry author = nan title = 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date = 2019-10-01 pages = extension = .txt mime = text/plain words = 87645 sentences = 4817 flesch = 46 summary = The primary objective of COGiTATE (CppOpt GuIded Therapy Assessment of Target Effectiveness) is to demonstrate feasibility of individualising CPP at CPPopt in TBI patients, expressed as the percentage of monitoring time for which CPP is within 5 mmHg of regularly updated CPPopt targets during the first 5 days of Intensive Care Unit (ICU) admission. Neurocritical care has become increasingly subspecialized.Yet, due to limited availability of dedicated Neurocritical Care units (NCCUs), often patients may need to be admitted to ICUs other than NCCUs. This survey based study was conducted to explore self-reported knowledge in recognizing and managing some common neurological emergencies such as stroke, status epilepticus, raised intracranial pressure etc among critical care nurses at a Comprehensive Stroke Center. Coagulation factor Xa (recombinant), inactivated-Xa inhibitor associated life--factor prothrombin complex concentrate (PCC) was utilized offRetrospective, single center, cohort study including adult intracranial hemorrhage patients who received discharge between efficacy (defined by International Society on Thrombosis and Haemostasis criteria), thrombotic events, ICU and hospital length of stay, and mortality. cache = ./cache/cord-006182-kck5e1ry.txt txt = ./txt/cord-006182-kck5e1ry.txt === reduce.pl bib === id = cord-295633-vkjcheaz author = Hao, Xin‐yan title = The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose‐only exposure device date = 2019-10-30 pages = extension = .txt mime = text/plain words = 5108 sentences = 255 flesch = 50 summary = After infection, we analyzed the mouse characteristics of weight loss, survival, viral replication, tissue pathology, viral antigen distribution, and cytokine and chemokine profiles, which provide additional data to investigate the pathogenesis of MERS-CoV-induced disease and evaluate relevant therapeutics and vaccines. Instillation control DMEM suspension To analyze clinical signs, weight loss, and survival On days 3, 5, 7, and 9 postinfection, three animals randomly selected from each group underwent necropsy to obtain tissue specimens for assessing viral distribution, associated histopathology, and cytokine levels using quantitative reverse transcription-PCR (qRT-PCR), hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA). *P < .05, **P < .01, ***P < .001, and ****P < .0001 Mice in the instillation group died acutely or were euthanized when they researched 25% weight loss; these mice had a 0% survival rate by day 5, so no tissue lesion results were available on days 7 and 9 mice infected with MERS-CoV via the aerosol inhalation or intranasal instillation route, but no obvious lesions were found in other tissues. cache = ./cache/cord-295633-vkjcheaz.txt txt = ./txt/cord-295633-vkjcheaz.txt === reduce.pl bib === id = cord-014976-546zaoxn author = nan title = Publication only date = 2006-03-08 pages = extension = .txt mime = text/plain words = 51926 sentences = 2983 flesch = 53 summary = In order to evaluate if malignant and non malignant hematological diseases quantitatively and qualitatively affect BM derived MSCs, bone marrow from children with acute lymphoblastic leukemia (ALL diagnosis n=9, different phases of treatment n=29, end of therapy n=10), idiopathic thrombocytopenic purpura (n=16), autoimmune neutropenia (n=12) and control patients (solid tumors without BM involvement, n=30) was harvested and the mononuclear cell (MNC) fraction isolated. Case: In our hospital a total of 3 patients with relapsed Hodgkin's disease underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) from an HLA-identical sibling. We report a case of a young male patient of 19 years old with aggressive MS who was treated with a high-dose immunosuppressive regimen (HDIS) using myeloablation followed by autologous blood stem cell transplantation (ASCT) that has induced a dramatic and long-lasting remission of the disease. cache = ./cache/cord-014976-546zaoxn.txt txt = ./txt/cord-014976-546zaoxn.txt === reduce.pl bib === id = cord-006880-9dgmdtj8 author = nan title = Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date = 2012-09-19 pages = extension = .txt mime = text/plain words = 82351 sentences = 4528 flesch = 49 summary = Patients initially comatose after cardiac arrest treated who awoke after therapeutic hypothermia (TH) were evaluated by a neuropsychologist prior to hospital discharge with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), a well-validated tool that assesses function in multiple domains compared to standardized normal values. Clinical data including the pre-admission-status, neuroradiological, initial presentation, treatment, and outcome were evaluated through institutional databases, patient's medical charts and by mailed questionnaires. To determine the differences in hospital outcomes among adult mild traumatic brain injury (TBI) patients where the severity of TBI is defined by Glasgow Coma Scale (GCS) score. Retrospective chart analysis was performed on all adult patients arriving to emergency department with history of fall at a level one trauma center for parameters like vomiting, alteration of consciousness (AOC) & loss of consciousness (LOC) after TBI; post-traumatic amnesia (PTA) and history of seizures before or after injury, along with outcomes such as ICU admission & ICU length of stay. cache = ./cache/cord-006880-9dgmdtj8.txt txt = ./txt/cord-006880-9dgmdtj8.txt === reduce.pl bib === id = cord-300570-xes201g7 author = Patwardhan, J. title = PREDICTIONS FOR EUROPE FOR THE COVID-19 PANDEMICAFTER LOCKDOWN WAS LIFTED USING AN SIR MODEL date = 2020-10-06 pages = extension = .txt mime = text/plain words = 5297 sentences = 247 flesch = 64 summary = The data is observed to fit the model as predicted until around 150 days after December 31, 2019, after which many countries lift their lockdowns and begin to reopen. An analysis of the residuals is provided to locate the precise date of the departure of each country from its accepted data estimates and test each data point to its predicted value using a Z-test to determine whether each observation can fit the given model. After around Day 170, the model predicts small X2 values with small standards of deviation, so observed residuals at this point mostly represent the growth of the virus itself during that time. Finally, an examination of the date of the first deaths in each country compared to the days until the model began to deviate from its expected behavior yields no relation, indicating that any failure of the observed data points to conform to the model is most likely due to the policy measures taken in each country. cache = ./cache/cord-300570-xes201g7.txt txt = ./txt/cord-300570-xes201g7.txt === reduce.pl bib === id = cord-295703-no45mgyd author = ALTAY, O. title = Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 date = 2020-10-05 pages = extension = .txt mime = text/plain words = 3977 sentences = 231 flesch = 50 summary = Combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and L-carnitine tartrate is being studied for the treatment of patients with COVID-19. CONCLUSIONS In patients with mild-to-moderate COVID-19, CMCS resulted in a significant reduction in recovery time and liver enzymes associated with hepatic function compared to placebo. Recently, we performed integrative analysis of multi-omics data on different metabolic conditions and found that combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and Lcarnitine tartrate may be used for treatment of the patients with non-alcoholic fatty liver diseases (11, 12) . In this randomized, open-label, placebo-controlled, phase 2 trial involving ambulatory COVID-19 patients, we found that the combination of CMCS and hydroxychloroquine significantly reduced the average recovery time compared with hydroxychloroquine and placebo (6.6 days vs 9.3 days, respectively). cache = ./cache/cord-295703-no45mgyd.txt txt = ./txt/cord-295703-no45mgyd.txt === reduce.pl bib === id = cord-014464-m5n250r2 author = Sole-Violan, J title = Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date = 2013-03-19 pages = extension = .txt mime = text/plain words = 98961 sentences = 5553 flesch = 54 summary = Results In preliminary analysis of categorical data, a signifi cantly (Fisher exact test) greater proportion of patients with compared with without the following fi ndings did not survive; history of alcohol use (P = 0.05); the presence of lethargy (P = 0.01), confusion (P = 0.03), nausea (P = 0.04), abdominal pain (P = 0.02), or the need for vasopressors (P = 0.002), oxygen, mechanical ventilation, or steroids (all P = 0.004) at presentation; and excessive bleeding at surgery (P = 0.01). Methods To prospectively re-evaluate the normal range and to analyze the potential impact of biometric data on ICG-PDR, we measured ICG-PDR (i.v. injection of 0.25 mg/kg ICG; LiMON, Pulsion, Munich, Introduction Mixed venous oxygen saturation (SVO 2 ) represents a well-recognized parameter of oxygen delivery (DO 2 )-consumption (VO 2 ) mismatch and its use has been advocated in critically ill patients in order to guide hemodynamic resuscitation [1] and oxygen delivery optimization. cache = ./cache/cord-014464-m5n250r2.txt txt = ./txt/cord-014464-m5n250r2.txt === reduce.pl bib === id = cord-275828-c6d6nk7x author = Mikasa, Keiichi title = JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date = 2016-07-31 pages = extension = .txt mime = text/plain words = 39672 sentences = 2522 flesch = 42 summary = -SBT/ABPC, intravenous drip, 3 g/3e4 times a day -CTRX, intravenous drip, 1 g/twice a day or 2 g/once a day -CTX, intravenous drip, 1e2 g/2e3 times a day -LVFX, intravenous drip, 500 mg/once a day (2) Cases of late-onset hospital-acquired pneumonia or ventilator-associated pneumonia in which the risk of resistant bacteria is high An antimicrobial drug with anti-pseudomonal activity that targets non-glucose-fermentative gram-negative rod should be administered [50, 51, 68] -To treat polymicrobial infection, the administration of an antimicrobial drug with an activity against obligate anaerobe is not always necessary [67, 70] . -SBT/ABPC, intravenous drip, 3 g/3e4 times a day -CTRX, intravenous drip, 2 g/once a day or 1 g/twice a day -CTX, intravenous drip, 1e2 g/2e3 times a day -LVFX, intravenous drip, 500 mg/once a day (2) Late-onset hospital-acquired pneumonia or cases in which there is a risk of multi-drug-resistant bacteria In addition to the above pathogens, the involvement of non-glucose-fermentative gram negative bacteria or ESBLproducing enteric bacteria must be considered. For the treatment of immunodeficiency-/blood disease-related pneumonia in children, antimicrobial drug therapy should also be basically selected, considering causative microorganisms. cache = ./cache/cord-275828-c6d6nk7x.txt txt = ./txt/cord-275828-c6d6nk7x.txt === reduce.pl bib === id = cord-005497-w81ysjf9 author = nan title = 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date = 2020-03-24 pages = extension = .txt mime = text/plain words = 103623 sentences = 6176 flesch = 53 summary = The positive NC group had more plasma transfusion (p-value 0.03) and a lower median hematocrit at 24 hrs (p-value 0.013), but similar hospital length of stay (p=0.17) and mortality rate (p=0.80) Conclusions: NC at ICU admission identifies subclinical AKI in TBI patients and it maight be used to predictclinical AKI. In patients with pneumonia requiring intensive care (ICU) admission, we hypothesise that abnormal right ventricular (RV) function is associated with an increased 90-day mortality. The objective of this study was to describe the incidence of each AKI stages as defined by KDIGO definition (with evaluation of urine output, serum creatinine and initiation of renal replacement therapy (RRT)), in a mixed medical and surgical population of patients hospitalized in ICU and PCU over a 10-year period (2008-2018). This study aimed at investigating the relationship of goal-directed energy and protein adequacy on clinical outcomes which includes mortality, intensive care unit(ICU) and hospital length of stay (LOS), and length of mechanical ventilation (LOMV). cache = ./cache/cord-005497-w81ysjf9.txt txt = ./txt/cord-005497-w81ysjf9.txt === reduce.pl bib === id = cord-299343-gsrgf4dd author = Wilson, A. M. title = Quantifying SARS-CoV-2 infection risk within the Apple/Google exposure notification framework to inform quarantine recommendations date = 2020-07-19 pages = extension = .txt mime = text/plain words = 10689 sentences = 493 flesch = 48 summary = The conditional probability of current or future infectiousness, conditioned on how long post-exposure an exposed individual has been free of symptoms, decreases during quarantine, with shape determined by the distribution of incubation periods, proportion of asymptomatic cases, and distribution of asymptomatic shedding durations. Findings: As an example of our calculations, fifteen minutes of close contact with a high-shedding individual, given a 15% asymptomatic infection rate and no testing, would require 5and 14-day quarantine for their risk of current or future infectiousness to fall below 0.84% and 0.14% risk, respectively. A similarly maximal interaction, i.e. with 30 minutes in each attenuation bin, but with an index case at the minimum Transmission Risk level, corresponding to exposure timing that is not risk-free but falls just outside the window currently used by manual contact tracers, yields an infection probability of 0.36%, requiring 7 days of quarantine. cache = ./cache/cord-299343-gsrgf4dd.txt txt = ./txt/cord-299343-gsrgf4dd.txt === reduce.pl bib === id = cord-306705-adshd3jj author = Lenander-Lumikari, Marianne title = Effects of the common cold and intranasal fluticasone propionate treatment on mucosal host defense assessed by human saliva()()() date = 2005-11-04 pages = extension = .txt mime = text/plain words = 2899 sentences = 169 flesch = 55 summary = title: Effects of the common cold and intranasal fluticasone propionate treatment on mucosal host defense assessed by human saliva()()() 11 To extend these findings, this study analyzed salivary flow rate and selected major host antimicrobial components present in whole saliva in patients with the common cold. The purpose of this investigation was to study the effect of a potent topical steroid, fluticasone propionate, on patients with early signs and symptoms of the common cold. Salivary flow rate, innate host defense factors, and total protein content were not affected by the common cold. Salivary flow rate, innate host defense factors, and total protein content were not affected by the common cold. Neither the common cold nor the fluticasone propionate treatment had any effect on the relative amounts of secreted IgG or IgM immunoglobulins. Therefore, the salivary IgA response was probably induced by the viruses, and the treatment of the common cold with fluticasone propionate did not have any negative influence on this defense factor. cache = ./cache/cord-306705-adshd3jj.txt txt = ./txt/cord-306705-adshd3jj.txt === reduce.pl bib === id = cord-005727-li8pwigg author = nan title = ESICM 2010 MONDAY SESSIONS 11 October 2010 date = 2010-08-31 pages = extension = .txt mime = text/plain words = 102770 sentences = 6408 flesch = 53 summary = Since, continuous epidural analgesia provides the required level of analgesia to support early mobilization and significant reduction in pulmonary and cardiovascular morbidity in the early postoperative period, we postulated that the use of low dose of continuous epidural morphine might improve postoperative analgesia and reduce undesirable side effects in elderly patientsTherefore, the present study was designed to evaluate the effects of morphine administered via epidural patients controlled analgesia and intravenous tramadol + metamizol on postoperative pain control and side effects in elderly patients after major abdominal surgery. For each ventilated patient the following data was registered:Age, APACHE II, the reason of admission, risk factors, use NIV, MV duration, timing of tracheostomy, time of diagnosis of VAP, microbiological data, length of stay and mortality in ICU. 23rd ESICM ANNUAL CONGRESS -BARCELONA, SPAIN -9-13 OCTOBER 2010 S131 Evaluated factors: patient characteristics, signs, symptoms, abscess location, time between symptoms and hospital admission and surgery, lab results, microbiology, antibiotic therapy, APACHE2, SAPS2, SOFA, length of ICU stay, surgical re-intervention, duration of mechanical ventilation, infectious complications, critical illness myopathy (CIM), renal replacement therapy (RRT), re-intubation, tracheotomy, mortality. cache = ./cache/cord-005727-li8pwigg.txt txt = ./txt/cord-005727-li8pwigg.txt === reduce.pl bib === id = cord-309588-kw4d32dt author = Chan, Michael H.M. title = Steroid-induced osteonecrosis in severe acute respiratory syndrome: a retrospective analysis of biochemical markers of bone metabolism and corticosteroid therapy date = 2006-06-30 pages = extension = .txt mime = text/plain words = 4614 sentences = 245 flesch = 46 summary = Summary Aim We investigated the effect of massive doses of corticosteroid therapy on bone metabolism using specific biochemical markers of bone metabolism, and the prevalence of osteonecrosis in severe acute respiratory syndrome (SARS) patients at a university teaching hospital in Hong Kong. Biochemical markers of bone metabolism were analysed retrospectively using serial clotted blood samples collected from each patient during the course of hospital admission to discharge and subsequent follow-up at out-patient clinic using the arbitrary time periods: (i) Day <10; (ii) Day 28-44; (iii) Day 51-84; and (iv) Day >90 after the onset of fever. Aim: We investigated the effect of massive doses of corticosteroid therapy on bone metabolism using specific biochemical markers of bone metabolism, and the prevalence of osteonecrosis in severe acute respiratory syndrome (SARS) patients at a university teaching hospital in Hong Kong. 9, 10 In this study, biochemical markers of bone metabolism were used retrospectively to investigate the effect of massive doses of pulse and maintenance corticosteroid therapies on patients with SARS. cache = ./cache/cord-309588-kw4d32dt.txt txt = ./txt/cord-309588-kw4d32dt.txt === reduce.pl bib === id = cord-310249-cvv77f10 author = Yule, Terecita D. title = Canine parvovirus vaccine elicits protection from the inflammatory and clinical consequences of the disease date = 1997-05-31 pages = extension = .txt mime = text/plain words = 4606 sentences = 247 flesch = 45 summary = In canine parvovirus infected puppies we measured the levels of acute phase proteins and changes in leukocyte phenotypes and cell trafficking by flow cytometry. In this study we evaluated whether measuring levels of acute phase proteins and investigating changes in leukocyte phenotypes by flow cytometry would complement conventional clinical assessment of a vaccine efficacy study. The association of these parameters with the major clinical signs of parvovirus induced disease in vaccinated vs nonvaccinated animals is described for seropositive puppies given a CPV-2 vaccine followed by experimental infection with CPV-2b. Low but significant SAA values were observed in three vaccinates on sporadic days post-challenge, but these values did not coincide with clinical signs, virus shed or hematologic changes. Using cell specific antibodies and flow cytometric analysis, a mean of 88% of leukocytes in peripheral Days Post CPV-2 Challenge blood were positively identified as T-cells (CD4+ and CD@, pan-T), B-cells, monocytes, and neutrophils when compared to the absolute leukocyte count obtained conventionally. cache = ./cache/cord-310249-cvv77f10.txt txt = ./txt/cord-310249-cvv77f10.txt === reduce.pl bib === id = cord-304562-5xh4p786 author = Tanabe, Naoya title = Dupilumab maintenance therapy in an asthmatic patient with coronavirus disease 2019 pneumonia date = 2020-11-07 pages = extension = .txt mime = text/plain words = 667 sentences = 52 flesch = 57 summary = Dupilumab is widely used as an important biologic 33 agent to control severe condition of asthma, eosinophilic chronic rhinosinusitis, 34 and atopic dermatitis. In the pandemic of severe acute respiratory 35 syndrome-coronavirus-2 (SARS-CoV-2) and its associated respiratory disease, clinical course is summarized in Figure 1 . On day12, chest 51 computed tomography (CT) showed bilateral peripheral-dominant ground glass 52 opacity (GGO) and consolidation ( Fig. 2A) , and because he had several risk 53 factors for severe COVID-19 including obesity and diabetes, he was transferred 54 to intensive care unit at our hospital and received oxygen therapy via face mask 55 (5-6 L/min). Then, mepolizumab Dupilumab is an essential biologic agent for severe type of asthma, 84 eosinophilic chronic rhinosinusitis, and atopic dermatitis. Type 2 inflammation modulates ACE2 and TMPRSS2 in airway 155 epithelial cells Asthma 166 exacerbation associated with COVID-19 pneumonia cache = ./cache/cord-304562-5xh4p786.txt txt = ./txt/cord-304562-5xh4p786.txt === reduce.pl bib === id = cord-314235-08z2jyzd author = Matzinger, P. title = Strong impact of closing schools, closing bars and wearing masks during the Covid-19 pandemic: results from a simple and revealing analysis date = 2020-09-28 pages = extension = .txt mime = text/plain words = 5932 sentences = 304 flesch = 64 summary = This change 10 occurred 15 days after schools closed, 12 days after bars and restaurants closed, and one day before the state lockdown, suggesting that the effect of one or both of the first two policy 15 decisions was to reduce the doubling rate of cases to slightly more half of the original rate. Figure 1C shows the effect of the lockdown in MD, which was followed twelve days later by an 25 additional threefold change in doubling time, from 4.7 to 12.8 days, and similar rate reductions in hospitalizations and deaths with additional lags of 2 and 6 days respectively. The results, demonstrate that, other than full lockdowns, three government interventions had the most impact on the rates of Covid-19 infections: closing schools, closing bars and wearing masks. cache = ./cache/cord-314235-08z2jyzd.txt txt = ./txt/cord-314235-08z2jyzd.txt === reduce.pl bib === id = cord-006870-f5w6fw6q author = nan title = Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting date = 2017-09-19 pages = extension = .txt mime = text/plain words = 122221 sentences = 6828 flesch = 47 summary = Subjective perceptions of recovery were assessed via responses to the forced-choice dichotomized question, "Do you feel that you have made a complete recovery from the arrest?"Objective outcome measures of recovery included: Repeatable Battery for Neuropsychological Status (RBANS), Modified Lawton Physical Self-Maintenance Scale (L-ADL), Barthel Index (BI), Cerebral Performance Category Scale (CPC), Center for Epidemiological Studies-Depression scale (CES-D), and Post traumatic stress disorder-checklist (PTSD-C). Utilizing data from the Citicoline Brain Injury Treatment (COBRIT) trial, a prospective multicenter study, we identified 224 patients who met the inclusion criteria; 1) placement of an ICP monitoring device, 2) Glasgow coma score (GCS) less than 9, 3) EVD placement prior to arrival or within 6 hours of arrival at the study institution. The objective of this study was to examine the incidence rates of pre-specified medical and neurological ICU complications, and their impact on post-traumatic in-hospital mortality and 12month functional outcomes. cache = ./cache/cord-006870-f5w6fw6q.txt txt = ./txt/cord-006870-f5w6fw6q.txt === reduce.pl bib === id = cord-303878-v2n9jeeb author = Stiles, Jonathan title = Working at home and elsewhere: daily work location, telework, and travel among United States knowledge workers date = 2020-09-05 pages = extension = .txt mime = text/plain words = 7665 sentences = 324 flesch = 50 summary = (2017) used Canadian time use data to explore the relationship of working from different locations with travel, finding that some patterns of working from home were associated with less overall travel, a decreased likelihood of traveling at peak travel times, and an increased likelihood of using a non-motorized form of transport. The third section presents the results from the peak hour travel participation multinomial logistic regression models, and the final section augments this with a survival analysis of initial departure times to shed light on a mechanism of morning peak hour avoidance related to homebased work. When we combine homeworking with other non-workplace locations, such as someone who works at home in the morning and goes to a café to work later in the day, the higher likelihood of avoidance of at least some peak hour work travel remains. cache = ./cache/cord-303878-v2n9jeeb.txt txt = ./txt/cord-303878-v2n9jeeb.txt === reduce.pl bib === id = cord-301947-b6nwaost author = Millán-Oñate, José title = Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin date = 2020-04-24 pages = extension = .txt mime = text/plain words = 3699 sentences = 205 flesch = 48 summary = We report here the clinical features and therapeutic course of the first reported patient with confirmed COVID-19 pneumonia that recovered in Colombia, after the use of chloroquine and clarithromycin. It is essential to acknowledge that no good controlled data are supporting the use of any of these agents, except for a recent randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, that showed no benefit with lopinavir-ritonavir (LPV/RTV) treatment beyond standard care [13] . We present a confirmed case of COVID-19 from Buga, Valle del Cauca, Colombia, that successful recovered of SARS-CoV-2 infection after receiving chloroquine. Although that just based in one case, we cannot recommend the use of these drugs, our patient improved significantly, and his clinical manifestations ceased, including becoming negative for the SARS-CoV-2 infection, as observed in the rRT-PCR test. cache = ./cache/cord-301947-b6nwaost.txt txt = ./txt/cord-301947-b6nwaost.txt === reduce.pl bib === id = cord-300810-a1skdp67 author = Lafay, F. title = Spread of the CVS strain of rabies virus and of the avirulent mutant AvO1 along the olfactory pathways of the mouse after intranasal inoculation date = 1991-07-31 pages = extension = .txt mime = text/plain words = 5731 sentences = 292 flesch = 54 summary = title: Spread of the CVS strain of rabies virus and of the avirulent mutant AvO1 along the olfactory pathways of the mouse after intranasal inoculation Abstract After intranasal instillation in the mouse, rabies virus (CVS strain) selectively infected olfactory receptor cells. On the other hand, other neuronal cells permissive for CVS, such as mitral cells or the anterior olfactory nucleus, are completely free of infection with the mutant, indicating that restriction is related to the ability of AvO1 to penetrate several categories of neurons. The G protein plays a pivotal role in the pathogenicity of the virus because of its interaction with the host cells ' Abbreviations used: AON, anterior olfactory nucleus; CNS, central nervous system; GABA, Gamma aminobutyric acid; HDB, horizontal limb of the diagonal band; HRP, horseradish peroxidase; HSVl, herpes simplex type 1; IPL, internal plexiform layer: LC, locus coeruleus; LD50, lethal dose 50%; LPA. cache = ./cache/cord-300810-a1skdp67.txt txt = ./txt/cord-300810-a1skdp67.txt === reduce.pl bib === id = cord-324553-qd8249w3 author = Cadegiani, F. A. title = An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV Female Trial. date = 2020-10-06 pages = extension = .txt mime = text/plain words = 6393 sentences = 402 flesch = 51 summary = The present study aimed to evaluate the effects of any early pharmacological approach to females diagnosed with COVID-19 before seven days of symptoms, as well as investigate whether HA is an additional risk factor in this population. Materials and methods: Females with symptoms for less than seven days confirmed for COVID-19 through positive real-time polymerase chain reaction (rtPCR-SARS-CoV-2) were classified and divided as non-HA, HA, and HA using spironolactone (HA-spiro) groups. Conclusions: A sensitive, early detection of COVID-19 followed by a pharmaceutical approach with different drug combinations yielded irrefutable differences compared to sex-, age-, body mass index (BMI)-, and disease-matched non-treated controls in terms of clinical outcomes, ethically disallowing placebo-control randomized clinical trials in the early stage of COVID-19 due to the marked improvements. Several different molecules demonstrated in vitro antiviral activity against SARS-CoV-2 and have been proposed as promising therapies for COVID-19 (13) , among which the most attempted drug combinations included azithromycin in the majority of the cases, in association with hydroxychloroquine, ivermectin or nitazoxanide (13, 14) . cache = ./cache/cord-324553-qd8249w3.txt txt = ./txt/cord-324553-qd8249w3.txt === reduce.pl bib === id = cord-305365-50uojtet author = Easson, Will title = A review of rabbit and rodent production medicine date = 2001-07-31 pages = extension = .txt mime = text/plain words = 5416 sentences = 316 flesch = 57 summary = This review article outlines the essentials of production medicine (factors affecting production colony output) in rabbits and rodents, emphasizing the importance of routine management methods and record-keeping as well as disease control. Dystocia is not a common problem in rabbits, but when seen it is usually caused by obesity, a large fetus (particularly in small litters), or malpresentation. Infertility can be caused by the following factors: obesity; nutritional deficiencies; metritis; high environmental temperatures (>29~ poor lighting (low intensity or <10 hours/day); disease (eg, respiratory infection, skin mites, gastrointestinal disease, cystic ovaries); overcrowding; aged boars or sows; and mechanical impediments (eg, sawdust or the waxy secretion boars accumulate in their groin and scrotal regions). It is caused by the energy requirements of the last stages of gestation and of increasing lactation, particularly in primiparous obese sows that become anorexic for any reason (eg, any stress or disease) or who have a low-energy diet in this critical month. cache = ./cache/cord-305365-50uojtet.txt txt = ./txt/cord-305365-50uojtet.txt === reduce.pl bib === id = cord-326143-6ndqgxy8 author = Wang, Qiang title = Successful recovery of severe COVID-19 with cytokine storm treating with extracorporeal blood purification date = 2020-05-26 pages = extension = .txt mime = text/plain words = 1325 sentences = 89 flesch = 59 summary = COVID-19 associated cytokine storm could induce ARDS rapidly and the patients would require the support of mechanic ventilation. We present a case of severe SARS-CoV-2 infection who recovered from cytokine storm. The patients with confirmed COVID-19 progressed to acute respiratory distress syndrome (ARDS) rapidly in an incident rate as high as 41.8% 1 , and many of them require mechanic ventilation. Cytokines could be eliminated effectively by extracorporeal blood purification (EBP) 4 , which thus could interrupt the initiation and progression of inflammation cascade in the scenario of COVID-19. IL-6 (198.66 pg/ml) was almost 10 folds of normal range (≤5.9 pg/ml) which indicated an initiation of cytokine storm on day 12 ( Figure 1 ). The patient was largely stable until the chest distress exacerbated and blood in phlegm developed on day 14. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease cache = ./cache/cord-326143-6ndqgxy8.txt txt = ./txt/cord-326143-6ndqgxy8.txt === reduce.pl bib === id = cord-317347-by8albr9 author = van Ginkel, Frederik W. title = Age-dependent immune responses and immune protection after avian coronavirus vaccination date = 2015-05-28 pages = extension = .txt mime = text/plain words = 5792 sentences = 288 flesch = 53 summary = The delayed and/or lower antibody response combined with lower IgG avidity indices coincided with increased tracheal inflammation and depletion of tracheal epithelia cells and goblet cells upon IBV field strain challenge. Therefore, the ability of SPF chickens of different age to induce an IBV-specific antibody response and protect against challenge with an IBV field strain was measured. In order to measure IgG (IgY), IgA and IgM antibody levels in plasma and tears of chicken, an IBV-specific enzyme-linked immunosorbent assay (ELISA) was developed as previously described [20] . These data are consistent with a delay in the IgA plasma response to IBV in birds vaccinated at a younger age and a non-significant decline in mean IgA titers in the 1-day-old group. This would be consistent with a drop of presumably natural maternal IBV-specific IgM antibodies in these SPF chickens in the day 7 control age group. cache = ./cache/cord-317347-by8albr9.txt txt = ./txt/cord-317347-by8albr9.txt === reduce.pl bib === id = cord-330414-yh58ya39 author = Agarwal, Deepak K. title = Catheter Removal on the Same Day of Holmium Laser Enucleation of the Prostate: Outcomes of a Pilot Study date = 2020-10-10 pages = extension = .txt mime = text/plain words = 2600 sentences = 148 flesch = 47 summary = title: Catheter Removal on the Same Day of Holmium Laser Enucleation of the Prostate: Outcomes of a Pilot Study OBJECTIVES: To determine if same day catheter removal is feasible in select population after holmium laser enucleation of the prostate (HoLEP). For patients who successfully passed their voiding trial, the median time from the end of the procedure to hospital discharge was 2.6 hours (IQR (2.1-2.9) and from the end of the HoLEP to catheter removal was 4.9 hours (IQR 3.5-6.0). Patients who were not offered same day catheter removal were those with prostate volumes >250 ml on preoperative imaging study (all were required to have imaging to be considered). The rate of passage of voiding trial on the same day as surgery is also similar to recent studies, 11, 12 demonstrating there is no added risk to patient of catheter reinsertion after BPH procedures. cache = ./cache/cord-330414-yh58ya39.txt txt = ./txt/cord-330414-yh58ya39.txt === reduce.pl bib === id = cord-318994-1xngjndu author = Lier, Audun J. title = Case Report: Disseminated Strongyloidiasis in a Patient with COVID-19 date = 2020-08-14 pages = extension = .txt mime = text/plain words = 1966 sentences = 130 flesch = 42 summary = We report a case of a COVID-19 patient who developed disseminated strongyloidiasis following treatment with high-dose corticosteroids and tocilizumab. Screening for Strongyloides infection should be pursued in individuals with COVID-19 who originate from endemic regions before initiating immunosuppressive therapy. This report describes the clinical features of a case of disseminated strongyloidiasis infection and polymicrobial bacteremia in an individual who received immunosuppressive treatment for COVID-19. 11 Given our patient's epidemiologic risk factor and development of Gram-negative bacteremia, the clinical diagnosis of disseminated strongyloidiasis was further supported. The initial Strongyloides serology on hospital day 21 was negative, but the repeat was positive on day 38. 8 This case highlights important considerations when using immunosuppressive therapies for COVID-19 treatment, particularly in patients with risk factors for prior Strongyloides infection. Clinical suspicion for disseminated strongyloidiasis should be maintained in patients from endemic areas who develop Gram-negative sepsis or meningitis. cache = ./cache/cord-318994-1xngjndu.txt txt = ./txt/cord-318994-1xngjndu.txt === reduce.pl bib === id = cord-324345-j43rpvwk author = Leong, Hoe Nam title = SARS – My personal battle date = 2010-11-19 pages = extension = .txt mime = text/plain words = 3111 sentences = 219 flesch = 70 summary = I vividly remember the time when I first saw the index patient with Severe Acute Respiratory Syndrome (SARS) in Singapore. The index patient was admitted to Tan Tock Seng Hospital (TTSH) on Saturday, (1st March 2003), and an infectious disease consult was sought on the following Monday. It was an exceedingly busy day for me as I had to attend to new referrals, run an outpatient clinic, and subsequently draft a clinical summary of these two patients by the early evening. Eventually, the patient's fever defervesced on day 14 of illness. I wasn't scheduled to perform the ward round that day, but I returned to visit the patient that Sunday morning. My wife and I telephoned a colleague in Singapore and we concurred to have a full blood count test done at the clinic the next day. My wife eventually joined me when she developed fever at the end of the second day of arrival. With that news, my days as a patient in isolation continued. cache = ./cache/cord-324345-j43rpvwk.txt txt = ./txt/cord-324345-j43rpvwk.txt === reduce.pl bib === id = cord-331347-imexhlwn author = Anzai, Asami title = Assessing the Impact of Reduced Travel on Exportation Dynamics of Novel Coronavirus Infection (COVID-19) date = 2020-02-24 pages = extension = .txt mime = text/plain words = 4470 sentences = 235 flesch = 55 summary = Data on confirmed cases diagnosed outside China were analyzed using statistical models to estimate the impact of travel reduction on three epidemiological outcome measures: (i) the number of exported cases, (ii) the probability of a major epidemic, and (iii) the time delay to a major epidemic. We aim to estimate reductions in the number of exported cases, probability of an outbreak occurring outside China, and any time delay to a major epidemic that may be gained with these policies. The present study explicitly quantified the epidemiological impact of reduced travel volume to and from China on the transmission dynamics of COVID-19 outside China using simple statistical The solid lines represent the probability of a major epidemic in the counterfactual scenario, i.e., based on the expected number of cases diagnosed in Japan. cache = ./cache/cord-331347-imexhlwn.txt txt = ./txt/cord-331347-imexhlwn.txt === reduce.pl bib === id = cord-333522-zsdymkjd author = Gruse, Jeannine title = Quercetin Feeding in Newborn Dairy Calves Cannot Compensate Colostrum Deprivation: Study on Metabolic, Antioxidative and Inflammatory Traits date = 2016-01-11 pages = extension = .txt mime = text/plain words = 7010 sentences = 333 flesch = 46 summary = Blood samples were taken repeatedly to measure plasma concentrations of flavonols, glucose, lactate, total protein, albumin, urea, non-esterified fatty acids, triglycerides, cholesterol, insulin, glucagon, cortisol, immunoglobulins, fibrinogen, haptoglobin and serum amyloid A. Basal blood samples were taken before the morning feeding on days 1, 2, 4 and 7 from the jugular vein using evacuated tubes containing either potassium-EDTA (1.2-2 mg/mL EDTA) for analyses of plasma metabolites, insulin, glucagon, immunoglobulins and acute-phase proteins or Li-heparin (12-30 IU heparin) for the determination of the cortisol and flavonol concentrations and the antioxidative status in the plasma. Feed intake, body temperature, heart and respiratory rate and plasma concentrations of metabolites, hormones, flavonols and markers of antioxidative status were analyzed by repeated measurement ANOVA using the MIXED procedure of SAS/STAT software and a model with the fixed factors diet, quercetin and day of life (repeated variable) and all interactions between the fixed factors. cache = ./cache/cord-333522-zsdymkjd.txt txt = ./txt/cord-333522-zsdymkjd.txt === reduce.pl bib === id = cord-335490-p63qlcnx author = Schenk, Thomas title = Disseminated Bocavirus Infection after Stem Cell Transplant date = 2007-09-17 pages = extension = .txt mime = text/plain words = 1928 sentences = 103 flesch = 46 summary = To the Editor: Human bocavirus (HBoV) (1) is increasingly recognized as a cause of respiratory infections worldwide. Retrospectively, the same NPA sample was reanalyzed for HBoV DNA by real-time PCR (7) and showed a viral load of 4.6 × 10 7 copies/mL (online Appendix Figure) ; specifi city was confi rmed by sequencing. Diarrheic stool samples obtained on day 21 and, after resolution of respiratory symptoms, on day 75 showed substantial HBoV DNA (2.5 × 10 6 and 6.0 × 10 5 copies/mg, respectively; online Appendix Figure) . Drug-induced PRCA is a rare blood disorder in adults and has already been reported in isoniazid-treated patients (3) (4) (5) . This hypothesis is supported by previously reported cases in which PRCA relapses occurred when treatment with isoniazid was resumed (3, 5) . Detection of human bocavirus in Japanese children with lower respiratory tract infections Human bocavirus DNA detected by quantitative real-time PCR in two children hospitalized for lower respiratory tract infection cache = ./cache/cord-335490-p63qlcnx.txt txt = ./txt/cord-335490-p63qlcnx.txt === reduce.pl bib === id = cord-327045-hn8pmcto author = Li, Yao title = Quercetin, Inflammation and Immunity date = 2016-03-15 pages = extension = .txt mime = text/plain words = 5360 sentences = 292 flesch = 40 summary = In vitro and some animal models have shown that quercetin, a polyphenol derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory and antiviral activities; as well as attenuating lipid peroxidation, platelet aggregation and capillary permeability. A study demonstrates that quercetin has a direct regulatory effect on basic functional properties of immune cells which may be mediated by the extracellular regulated kinase 2 (Erk2) mitogen-activated protein (MAP) kinase signal pathway in human mitogen-activated PBMC and purified T lymphocytes [54] . Quercetin most likely universally suppresses the accumulation and activation of immune cells, including anti-inflammatory cells, whereas it specifically increased gene expression associated with mitochondrial oxidative phosphorylation in Western diet-induced obese mice. showed that a supplement of 1000 mg of quercetin alone three weeks before, during and two weeks after a three-day period of 3 h of cycling in the winter resulted in a markedly lower incidence of URTI in well-trained subjects in the two weeks after the intensified training, but had no effect on exercise-induced immune dysfunction, inflammation and oxidative stress [76] . cache = ./cache/cord-327045-hn8pmcto.txt txt = ./txt/cord-327045-hn8pmcto.txt === reduce.pl bib === id = cord-006849-vgjz74ts author = nan title = 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date = 2019-09-13 pages = extension = .txt mime = text/plain words = 222162 sentences = 14023 flesch = 48 summary = Methods: We are performing this procedures within a prospective randomized trial that is design to compare the long term results of LRYGB-B versus the standard laparoscopic Roux-en-Y gastric bypass.The video shows our technique in a case of a 46 years old female with a BMI of 46 Kg/m2. Material and methods: We present a video of the surgical intervention of a 32-year-old patient, with functional dyspepsia, with a casual diagnosis of a pseudocystic mass of the right colon after performing a CT scan: giant diverticulum of the hepatic colon angle with fecaloid content inside it under tension The patient goes to the emergency room for acute abdominal pain, pending colonoscopy, antibiotic treatment is established, and a laparoscopic approach is decided upon after the patient's evolution. Method: We present the case of a 65-year-old patient with surgical antecedent of laparoscopic low anterior resection due to rectal cancer, presenting in postoperative period an anastomosis leakage with severe peritonitis was identified and a laparotomy with end colostomy was performed. cache = ./cache/cord-006849-vgjz74ts.txt txt = ./txt/cord-006849-vgjz74ts.txt === reduce.pl bib === id = cord-334667-0cah15lg author = Arabi, Yaseen M. title = Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial date = 2020-01-03 pages = extension = .txt mime = text/plain words = 3833 sentences = 204 flesch = 51 summary = title: Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial ABSTRACT: The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir and intErferon-β1b) investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant interferon-β1b provided with standard supportive care, compared to placebo provided with standard supportive care, in hospitalized patients with laboratory-confirmed MERS. Baseline characteristics will be presented for the two study groups (Additional file 1: Table S1 ) including age, sex, and body mass index, the presence of co-infections, nosocomial versus community-acquired MERS infection, Acute Physiology and Chronic Health Evaluation (APA-CHE) II scores, Sequential Organ Failure Assessment scores, and the Karnofsky Performance Status Scale score [3] . The MIRACLE trial investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant Interferon-β1b provided with standard supportive care, compared to placebo provided with standard supportive care, in hospitalized patients with laboratory-confirmed MERS. cache = ./cache/cord-334667-0cah15lg.txt txt = ./txt/cord-334667-0cah15lg.txt === reduce.pl bib === id = cord-337454-0h28a3az author = Chartier, C. title = Prophylaxis using paromomycin of natural cryptosporidial infection in neonatal kids date = 1996-01-31 pages = extension = .txt mime = text/plain words = 1704 sentences = 98 flesch = 61 summary = The first group consisted of 18 kids; of these, nine had been born on 9 February and had been treated with paromomycin; the other nine, born 2 days later were untreated controls. Except for the medicated kid from the second trial, all animals showed a distension of small and large intestines by Table 2 Comparison of cryptosporidial oocyst shedding score in treated ( paromomycin from day 2 to day 13 of age) and untreated kids; trial 2 Moreover, in the first group of animals where control kids were severely affected, paromomycin prevented diarrhea and mortality. At the end of the studies, on days 15-19, oocyst excretions of medicated animals did not differ from those of the controls. Recent studies conducted in calves at 60-120 pg kg-' for 7 days in experimental conditions (Naciri et al., 1993) should be duplicated in kids in field conditions and compared with the paromomycin prophylaxis schedule in order to define the most effective and convenient way to control cryptosporidiosis in goats. cache = ./cache/cord-337454-0h28a3az.txt txt = ./txt/cord-337454-0h28a3az.txt === reduce.pl bib === id = cord-319933-yp9ofhi8 author = Ruiz, Sara I. title = Chapter 38 Animal Models of Human Viral Diseases date = 2013-12-31 pages = extension = .txt mime = text/plain words = 28834 sentences = 1797 flesch = 46 summary = An experimental study with cell culture-adapted hepatitis Avirus in guinea pigs challenged by oral or intraperitoneal routes did not result in clinical disease, increase in liver enzymes, or seroconversion. 32 NHPs including marmosets, cotton-top tamarins, and rhesus macaques infected with Norwalk virus can be monitored for the extent of viral shedding; however, no clinical disease is observed in these models. 66, 67 Intracerebral and intranasal routes of infection resulted in a fatal disease that was highly dependent on dose, while intradermal and subcutaneous inoculations caused only 50% fatality in mice regardless of the amount of virus. A mouse-adapted (MA) strain of Dengue virus 2 introduced into AG129 mice developed vascular leak syndrome similar to the severe disease seen in humans. [138] [139] [140] [141] [142] [143] [144] Inoculation of WNV into NHPs intracerebrally resulted in the development of either encephalitis, febrile disease, or an asymptomatic infection, depending on the virus strain and dose. cache = ./cache/cord-319933-yp9ofhi8.txt txt = ./txt/cord-319933-yp9ofhi8.txt === reduce.pl bib === id = cord-343789-6tq0kcfd author = Al-Tawfiq, Jaffar A. title = Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study date = 2014-01-06 pages = extension = .txt mime = text/plain words = 2625 sentences = 153 flesch = 59 summary = title: Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study RESULTS: All patients were critically ill with acute respiratory distress syndrome treated with adjunctive corticosteroids and were on mechanical ventilation at the time of initiation of therapy. Since the discovery of Middle East respiratory syndrome coronavirus (MERS-CoV), the virus has caused 163 cases of disease, with a fatality rate of 43-50%. In a recent review, based on therapies used for the related severe acute respiratory syndrome (SARS) coronavirus, the possible use of interferon and ribavirin was considered as a therapeutic option. 8 The purpose of this study was to describe the outcome of the use of a combination of interferon-a2b and ribavirin in the management of five patients with MERS-CoV infections. 20 In a rhesus macaque model of MERS-CoV infection, the combination of interferon-a2b and ribavirin therapy was effective in limiting the disease and resulted in very mild radiographic evidence of pneumonia. cache = ./cache/cord-343789-6tq0kcfd.txt txt = ./txt/cord-343789-6tq0kcfd.txt === reduce.pl bib === id = cord-347716-ka2lm62r author = Usher, Craigan title = Existential Returns date = 2020-06-25 pages = extension = .txt mime = text/plain words = 1532 sentences = 79 flesch = 66 summary = In light of this and that we are one review short of the intended trio-this due to a child and adolescent psychiatry colleague needing to focus on leadership at her medical center (again, leaning into strengths)-I wished to share with you some thoughts on a favorite film. Groundhog Day tells the story of Pittsburgh meteorologist Phil Connors, who, alongside cameraman Larry, and TV producer Rita travels to Puxatawney, Pennsylvania, to film the annual Groundhog Day celebration. Groundhog Day illustrates many psychodynamic concepts and may speak to those of us whose mental lives are dominated by recurring thoughts of the existential, economic, and emotional hardships of others or questions like if or when schools and hospitals will return to "normal." In addition, the film suggests something that, at first glance, sounds quite odd: that doing the same thing over and over again is not, as some have said, the definition of insanity, but instead an insistence of hope. cache = ./cache/cord-347716-ka2lm62r.txt txt = ./txt/cord-347716-ka2lm62r.txt === reduce.pl bib === id = cord-337129-6wt6wzxv author = Navas de Solis, Cristobal title = Transient diabetes mellitus in a neonatal Thoroughbred foal date = 2010-10-07 pages = extension = .txt mime = text/plain words = 3127 sentences = 212 flesch = 55 summary = Objective – To describe the clinical presentation, treatment, and outcome of a neonatal foal diagnosed with transient Type 1 diabetes mellitus. During hospitalization the foal developed hyperglycemia concomitantly with low insulin concentration and an adequate response to exogenous insulin therapy supported a diagnosis of Type 1 diabetes mellitus. On follow up assessment the foal was found to be a healthy euglycemic animal with normal insulin concentration at 11 months of age. Type 1 diabetes mellitus should be considered a differential diagnosis for hyperglycemia in equine neonates and that it can be transient and managed successfully. The insulin concentration in normal foals from birth to 7 days of age is 13.5 AE 1.5 mU/mL. Low insulin concentrations accompanying hyperglycemia and an adequate response to exogenous insulin supports a diagnosis of Type 1 diabetes mellitus. The foal developed complications that resolved with appropriate care and was a healthy animal with normal glycemia and insulin concentration at 11 months of age. cache = ./cache/cord-337129-6wt6wzxv.txt txt = ./txt/cord-337129-6wt6wzxv.txt === reduce.pl bib === id = cord-347140-q8qis03p author = Dietz, Thomas title = Earth Day: 50 Years of Continuity and Change in Environmentalism date = 2020-04-17 pages = extension = .txt mime = text/plain words = 2463 sentences = 146 flesch = 49 summary = The first Earth Day took place on April 22 in the midst of this instability, and its campaigns and the environmental movement it birthed were inevitably influenced by the politics of the time. Although the event was heavily influenced by the US politics of the time, from an environmental perspective Earth Day crystallized the convergence of several themes that would define environmentalism for the decades that followed. In the case of climate change, although the proportion of the public who are concerned has increased over the last decade, a strong ideological split between Democrats and Republicans persists. Thus, as in 1970, we need to find ways to link scientific analysis to political action and overcome the polarization that has shaped and defined environmentalism in the US for the past half-century. Political polarization and long-term change in public support for environmental spending cache = ./cache/cord-347140-q8qis03p.txt txt = ./txt/cord-347140-q8qis03p.txt === reduce.pl bib === id = cord-350024-whne0l19 author = Anderson, Victoria L. title = Choosing the Right Antibiotic in Ambulatory Care date = 2006-11-28 pages = extension = .txt mime = text/plain words = 4730 sentences = 398 flesch = 51 summary = With the use of a system-based approach, this article defines the most common infections seen in ambulatory care and their most common causative organisms and gives antibiotic options with respect to efficacy, common side effects, and cost. Nurse practitioners can diagnose and manage most of these skin infections; however, in the case of necrotizing fasciitis this is a surgical emergency and requires immediate referral and hospitalization.The following clinical entities most commonly seen in outpatient care are described: cellulitis, impetigo, folliculitis, furuncles and carbuncles, necrotizing fasciitis, paronychia, onychomycoses, lice, scabies, and Lyme disease. GAS is the most common bacterial cause and requires treatment with antibiotics; therefore, the main objective in evaluating a patient in the primary care setting is to identify, rule out, and treat GAS. This section discusses infections of the genitourinary tract, including vaginitis, cervicitis, cystitis, and epididymitis with specific reference to the diagnosis and management of sexually transmitted diseases (STDs). cache = ./cache/cord-350024-whne0l19.txt txt = ./txt/cord-350024-whne0l19.txt === reduce.pl bib === id = cord-336000-v88bq4bx author = Barco, Stefano title = Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial date = 2020-09-09 pages = extension = .txt mime = text/plain words = 20392 sentences = 1064 flesch = 44 summary = OBJECTIVES: The OVID study will demonstrate whether prophylactic-dose enoxaparin improves survival and reduces hospitalizations in symptomatic ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe systemic, pulmonary, and vessel inflammation and coagulation activation. The OVID study will show whether prophylactic-dose enoxaparin improves survival and reduces any hospitalizations in ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe systemic, pulmonary, and vessel inflammation and coagulation activation. <30% of the expected number of patients six months after the enrolment of the first patient, also based on the course of SARS-CoV2 infections in Switzerland;  when the safety of the participants is doubtful or at risk, respectively, based on recommendations received from DSMB committee;  changes in accepted clinical practice that make the continuation of a clinical trial unwise, including the results of similar studies or the publication of international guidances. cache = ./cache/cord-336000-v88bq4bx.txt txt = ./txt/cord-336000-v88bq4bx.txt === reduce.pl bib === id = cord-343349-ftzjdvfj author = Bhatt, P. N. title = Experimental infection of adult axenic rats with Parker's Rat Coronavirus date = 1977 pages = extension = .txt mime = text/plain words = 2128 sentences = 131 flesch = 51 summary = Virus was recovered from the nasopharynx and trachea after twenty-four hours and from the lung by day three but was not detected in respiratory tract after seven days. Viral antigen was detected by indirect immunofluorescence in the mucosal epithelium of upper respiratory tract and in pulmonary alveolar septae from day two to six postinoculation. Dacryoadenitis did not occur, sialoadenitis was detected in only three rats and virus was recovered from only one submaxillary salivary gland. Coronavirus infection is common in laboratory rats and two antigenically related viruses, sialodacryoadenitis virus (SDAV) and Parker's rat coronavirus (PRCV), have been isolated from naturally-infected rats (2, 7) . Virus in lungs, tracheas, nasal washings, salivary glands and lacrimal glands was quantitated for individual rats. Virus was not detected in nasopharynx, trachea and lung a~ter day six and in other tissues after day seven except in ~he submaxillary salivary gland of one rat. cache = ./cache/cord-343349-ftzjdvfj.txt txt = ./txt/cord-343349-ftzjdvfj.txt === reduce.pl bib === id = cord-349329-f0pbd968 author = Bosteels, Cedric title = Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial date = 2020-06-05 pages = extension = .txt mime = text/plain words = 12411 sentences = 618 flesch = 45 summary = -Presence of acute hypoxic respiratory failure defined as (either or both)  saturation below 93% on minimal 2 l/min O2  PaO2/FiO2 below 350 -Admitted to specialized COVID-19 ward -Age 18-80 -Male or Female -Willing to provide informed consent Exclusion criteria -Patients with known history of serious allergic reactions, including anaphylaxis, to human granulocyte-macrophage colony stimulating factor such as sargramostim, yeast-derived products, or any component of the product. Study Interventions Confirmed or highly suspect COVID-19 patients with acute hypoxic respiratory failure (saturation below 93% on minimal 2 l/min O2 or PaO2/FiO2 <350) will be randomized to receive sargramostim 125mcg twice daily for 5 days as a nebulized inhalation on top of standard of care (active group), or to receive standard of care treatment (control group). cache = ./cache/cord-349329-f0pbd968.txt txt = ./txt/cord-349329-f0pbd968.txt === reduce.pl bib === id = cord-346836-6jyv0q5e author = Ikegami, Tetsuro title = The Pathogenesis of Rift Valley Fever date = 2011-05-06 pages = extension = .txt mime = text/plain words = 10419 sentences = 483 flesch = 46 summary = RVFV infection in humans usually causes a self-limiting, acute and febrile illness; however, a small number of cases progress to neurological disorders, partial or complete blindness, hemorrhagic fever, or thrombosis. This review describes the pathology of RVF in human patients and several animal models, and summarizes the role of viral virulence factors and host factors that affect RVFV pathogenesis. RVFV infection in humans primarily causes a self-limiting febrile illness; however, some patients develop hemorrhagic fever, neurological disorders, or blindness after the febrile period [5, 7, 8] . Inbred rat strains mimic the disparate human response to rift valley fever virus infection Clinical, virological and serological response of the west african dwarf sheep to experimental infection with different strains of rift valley fever virus cache = ./cache/cord-346836-6jyv0q5e.txt txt = ./txt/cord-346836-6jyv0q5e.txt === reduce.pl bib === id = cord-341063-3rqnu5bu author = nan title = 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date = 2018-03-29 pages = extension = .txt mime = text/plain words = 98602 sentences = 6494 flesch = 52 summary = Procacitonin (PCT) emerges as a possible predictive tool in cardiothoracic intensive care unit (CTICU).We aim at testing the predictive power of PCT for early morbidity, prolonged ventilation, ICU and hospital stay, in patients developing early fever after cardiac surgery Methods: A retrospective descriptive study done in tertiary cardiac center, enrolling patients who stayed for more than 24 hours post-operatively in the CTICU Risk stratification included additive Euro score and PCT immunoluminometricaly prior to surgery and every 48 hours in response to onset of fever. Prognostic accuracy of quick sequential organ failure assessment (qSOFA) score for mortality: systematic review and meta-analysis Introduction: The purpose of this study was to summarize the evidence assessing the qSOFA [1] , calculated in admission of the patient in emergency department (ED) or intensive care unit (ICU), as a predictor of mortality. cache = ./cache/cord-341063-3rqnu5bu.txt txt = ./txt/cord-341063-3rqnu5bu.txt === reduce.pl bib === id = cord-335975-m6lkrehi author = nan title = Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date = 2018-02-05 pages = extension = .txt mime = text/plain words = 89374 sentences = 5327 flesch = 52 summary = A qSOFA score relying on 3 simple clinical criteria (respiratory rate, mental status and systolic blood pressure) has been proposed to better identify septic patients with associated higher mortality outside the intensive care unit (Seymour CW et al., JAMA 2016) . We propose to determine whether the arterial oxygen pressure (PaO2) at intensive care unit (ICU) admission affects mortality at day 28 (D28) in patients with septic shock subjected to mechanical out-of-hospital ventilation. Conclusion: In this study, we report a significant association between hyperoxemia at ICU admission and mortality at D28 in patients with septic shock subjected to pre-hospital invasive mechanical ventilation. The aim of this study was to describe outcome of pediatric patient with hematologic disease hospitalized in our intensive care unit for respiratory failure and to investigate the clinical variables associated with mortality. cache = ./cache/cord-335975-m6lkrehi.txt txt = ./txt/cord-335975-m6lkrehi.txt === reduce.pl bib === id = cord-023095-4dannjjm author = nan title = Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011 date = 2011-05-03 pages = extension = .txt mime = text/plain words = 134226 sentences = 6834 flesch = 51 summary = The purpose of this study was to determine the short-term effects of ivabradine on heart rate (HR), blood pressure, left ventricular (LV) systolic and diastolic function, left atrial (LA) performance, and clinical tolerance in healthy cats after repeated oral doses. The goal of this study was to investigate the relationship between heart rate and ECG time intervals to body mass in apparently healthy horses and ponies and to calculate normal ranges for different weight groups. This study aimed to investigate the prevalence of hypercoagulability in PLN dogs based on thromboelastography (TEG), and to determine whether hypercoagulability in these patients could be predicted by clinical assessments that identify systemic hypertension (systolic blood pressure 4 160 mmHg), hypoalbuminemia (serum albumin o 2.7 mg/dl), antithrombin activity (o 70%), and degree of proteinuria (urine protein:creatinine ratio [UPC] ! cache = ./cache/cord-023095-4dannjjm.txt txt = ./txt/cord-023095-4dannjjm.txt === reduce.pl bib === === reduce.pl bib === id = cord-015021-pol2qm74 author = nan title = Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date = 1994 pages = extension = .txt mime = text/plain words = 162327 sentences = 9379 flesch = 50 summary = It is our current understanding that LPS is responsible for many of the pathophysiological events observed during gramnegative infections and that one of the major mechanisms leading to shock and death is the LPS-induced activation of macrophages resulting in the production and release of lipid and peptide mediators, among which tumor necrosis factor seems to be the most important. However plasma IL-6 estimation revealed a statistically significant reduction at 6 hours in tanrine-treated animals compared to glycino and TW controls ( Objective: To evaluate the effects of allogeneic blood transfusion, thermal injury and bacterial garage on interteukin 4 (IL-4), tumor necrosis factor alpha (TNF) production and host mortality and to study if the administration of thymopentth (THY) could affect these events. cache = ./cache/cord-015021-pol2qm74.txt txt = ./txt/cord-015021-pol2qm74.txt === reduce.pl bib === id = cord-005814-ak5pq312 author = nan title = 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date = 1995 pages = extension = .txt mime = text/plain words = 179164 sentences = 12028 flesch = 56 summary = Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. cache = ./cache/cord-005814-ak5pq312.txt txt = ./txt/cord-005814-ak5pq312.txt === reduce.pl bib === id = cord-005460-ezrn8cva author = nan title = Physicians – Poster Session date = 2017-07-28 pages = extension = .txt mime = text/plain words = 287105 sentences = 15681 flesch = 56 summary = Still the optimal combination of immunosuppressive agents with PTCy should be elucidated for different types of SCTs. We report the 2-year update of the prospective NCT02294552 single-center trial that evaluated risk-adapted graft-versushost disease (GVHD) prophylaxis with PTCy in related, unrelated and haploidentical SCTs. 200 adult patients (median age 32 y.o., range: 18-62) with hematologic malignancies, including AML (47.5%), ALL (26.5%), CML (10.5%), MDS (4%), and lymphomas (11.5%), were enrolled in the study. Long-term follow-up from the prospective randomized phase III multicenter trial comparing a standard GvHD prophylaxis with cyclosporine A and methotrexate with or without additional pretransplant ATLG (Grafalon, previously ATG-FRESENIUS S) (given 20 mg/kg/day, days − 3 to − 1) in unrelated donor hematopoietic cell transplantation after myeloablative conditioning resulted in a significant reduction of acute and chronic GvHD without compromising relapse rate and survival [1, 2, 3] . cache = ./cache/cord-005460-ezrn8cva.txt txt = ./txt/cord-005460-ezrn8cva.txt === reduce.pl bib === id = cord-005453-4057qib7 author = nan title = The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date = 2019-07-03 pages = extension = .txt mime = text/plain words = 275771 sentences = 16876 flesch = 56 summary = To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective, observational cohort study enrolled in 21 HID-SCT and 13 MSD-SCT recipients. The aim of this study is to identify the prognostic impact of pre-transplant TIM3 levels on early and late transplant related complications as well as post-transplant relapse and survival Methods: A total of 177 hematopoietic stem cell transplantation (HSCT) recipients with an initial diagnosis of acute leukemia [median age: 36(16-66) years; male/ female: 111/66] were included in the study. cache = ./cache/cord-005453-4057qib7.txt txt = ./txt/cord-005453-4057qib7.txt === reduce.pl bib === id = cord-010119-t1x9gknd author = nan title = Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date = 2017-09-04 pages = extension = .txt mime = text/plain words = 230193 sentences = 13234 flesch = 55 summary = Conclusion: The wide distribution in the concentration of bioactive lipids among 405 stored RBC units suggests that lipid degradation is highly donor-Background/Case Studies: To ensure availability of biological products to hospitals, blood banks have developed and validated multiple storage conditions for each of their products to maximize shelf life and quality. 1 The Department of Blood Transfusion, The PLA General Hospital, 2 The Department of Blood Transfusion, Air Force General Hospital, PLA Background/Case Studies: Recently, multi researches have reported that longer term-stored red blood cells(RBCs) units were associated with increased risks of clinically adverse events, especially in critically ill patients. Weak D types 1, 2 and 3 express all the major RhD epitopes and these patients can be managed as RhD-positive, which may lead to a reduction in unnecessary Rh immunoglobulin (RhIG) administration and conservation of RhD-negative RBCs. Study Design/Method: RHD genotyping was performed on all patient samples with weaker than expected or discrepant RhD typing results, utilizing a commercially available genotyping kit manufactured by Immucor (RHD BeadChip). cache = ./cache/cord-010119-t1x9gknd.txt txt = ./txt/cord-010119-t1x9gknd.txt ===== Reducing email addresses cord-007178-h0ordzm9 cord-018239-n7axd9bq cord-027811-vk3qnumx cord-005646-xhx9pzhj cord-014538-6a2pviol cord-336000-v88bq4bx cord-300570-xes201g7 cord-335975-m6lkrehi cord-355038-o2hr5mox Creating transaction Updating adr table ===== Reducing keywords cord-000705-w52dc97h cord-000059-5hwqdnx1 cord-002957-gw2cow0d cord-001192-zbogocki cord-002659-566uoozj cord-003533-8m0vyxq8 cord-000097-vueo83vk cord-007178-h0ordzm9 cord-015389-vwgai4k9 cord-001262-8s7g2wvd cord-006876-v2m5l5wz cord-007288-lzxi6q1p cord-002945-29nj4f05 cord-010130-28bt3x25 cord-018239-n7axd9bq cord-163587-zjnr7vwm cord-032240-xswtx940 cord-034257-kl2ccmz5 cord-021453-vf8xbaug cord-224211-6lsvjfqb cord-030957-45tc5ksf cord-029112-u507i0t0 cord-027259-f4sgobcz cord-027811-vk3qnumx cord-009772-pzxvicee cord-271298-7vk3wgw1 cord-266183-uzuda3ir cord-256015-tt58n0jk cord-006391-esnsa4u5 cord-257654-8u9m1k5q cord-280821-kc0ut4oy cord-005777-6rvfsx4p cord-266571-qbskh1uu cord-268341-103xf3dw cord-033791-q0wizf2n cord-271180-cnrs0zpg cord-274497-tqceazdp cord-023017-k6edtg58 cord-033453-557obi3r cord-006444-eq56zhtd cord-265891-jmpterrj cord-280242-2w2kl0uf cord-031315-p7jb4gf2 cord-015090-n6f4xupw cord-006344-de4dhv4b cord-283257-rh3bxvv7 cord-023100-0pqnsiid cord-268081-ytx6sf3x cord-274860-7ec2jcoq cord-007456-acbo4zs2 cord-018110-mcw4v13c cord-005816-i54q5gsu cord-032806-o6p861ms cord-276338-wpo1eyeg cord-285096-g9y3au1a cord-275427-00bwhaga cord-266156-xmf4emln cord-021555-rrverrsj cord-258696-01wj76es cord-022659-chwk2bs4 cord-292970-32mql9nq cord-288051-wp8v2mc5 cord-278224-sq7tokbx cord-275889-4qwp3um1 cord-006856-b1w25ob5 cord-287182-f0q8gfzc cord-287520-51kmd2ds cord-291315-y40s45iv cord-282158-08u3x1z4 cord-295086-tc3re52f cord-277077-kwaiorp8 cord-282268-f7mbdfr6 cord-295367-xhdki8jn cord-007064-nepgttxf cord-015126-cyhcbk1j cord-005646-xhx9pzhj cord-014538-6a2pviol cord-005478-5iu38pr6 cord-285812-l7dpv6nx cord-015024-2xzc0uc5 cord-006182-kck5e1ry cord-015369-72cjogxz cord-295633-vkjcheaz cord-014976-546zaoxn cord-300570-xes201g7 cord-006880-9dgmdtj8 cord-295703-no45mgyd cord-014464-m5n250r2 cord-275828-c6d6nk7x cord-299343-gsrgf4dd cord-005497-w81ysjf9 cord-005727-li8pwigg cord-306705-adshd3jj cord-309588-kw4d32dt cord-310249-cvv77f10 cord-304562-5xh4p786 cord-314235-08z2jyzd cord-303878-v2n9jeeb cord-006870-f5w6fw6q cord-301947-b6nwaost cord-300810-a1skdp67 cord-305365-50uojtet cord-324553-qd8249w3 cord-317347-by8albr9 cord-326143-6ndqgxy8 cord-330414-yh58ya39 cord-333522-zsdymkjd cord-318994-1xngjndu cord-324345-j43rpvwk cord-331347-imexhlwn cord-327045-hn8pmcto cord-006849-vgjz74ts cord-337454-0h28a3az cord-334667-0cah15lg cord-335490-p63qlcnx cord-343789-6tq0kcfd cord-319933-yp9ofhi8 cord-347716-ka2lm62r cord-337129-6wt6wzxv cord-350024-whne0l19 cord-336000-v88bq4bx cord-347140-q8qis03p cord-343349-ftzjdvfj cord-349329-f0pbd968 cord-346836-6jyv0q5e cord-335975-m6lkrehi cord-355038-o2hr5mox cord-341063-3rqnu5bu cord-023095-4dannjjm cord-005814-ak5pq312 cord-005460-ezrn8cva cord-005453-4057qib7 cord-010119-t1x9gknd cord-015021-pol2qm74 Creating transaction Updating wrd table ===== Reducing urls cord-010130-28bt3x25 cord-163587-zjnr7vwm cord-034257-kl2ccmz5 cord-029112-u507i0t0 cord-027259-f4sgobcz cord-027811-vk3qnumx cord-266183-uzuda3ir cord-005777-6rvfsx4p cord-280821-kc0ut4oy cord-265891-jmpterrj cord-031315-p7jb4gf2 cord-268081-ytx6sf3x cord-274860-7ec2jcoq cord-018110-mcw4v13c cord-002659-566uoozj cord-021555-rrverrsj cord-288051-wp8v2mc5 cord-278224-sq7tokbx cord-282158-08u3x1z4 cord-005478-5iu38pr6 cord-006182-kck5e1ry cord-295633-vkjcheaz cord-300570-xes201g7 cord-014464-m5n250r2 cord-299343-gsrgf4dd cord-295703-no45mgyd cord-275828-c6d6nk7x cord-314235-08z2jyzd cord-324553-qd8249w3 cord-317347-by8albr9 cord-331347-imexhlwn cord-006849-vgjz74ts cord-334667-0cah15lg cord-347716-ka2lm62r cord-336000-v88bq4bx cord-349329-f0pbd968 cord-005453-4057qib7 cord-010119-t1x9gknd cord-005460-ezrn8cva Creating transaction Updating url table ===== Reducing named entities cord-000705-w52dc97h cord-000059-5hwqdnx1 cord-002957-gw2cow0d cord-001192-zbogocki cord-002659-566uoozj cord-003533-8m0vyxq8 cord-000097-vueo83vk cord-007178-h0ordzm9 cord-001262-8s7g2wvd cord-007288-lzxi6q1p cord-002945-29nj4f05 cord-010130-28bt3x25 cord-163587-zjnr7vwm cord-018239-n7axd9bq cord-015389-vwgai4k9 cord-032240-xswtx940 cord-034257-kl2ccmz5 cord-224211-6lsvjfqb cord-030957-45tc5ksf cord-027811-vk3qnumx cord-029112-u507i0t0 cord-027259-f4sgobcz cord-009772-pzxvicee cord-266183-uzuda3ir cord-006876-v2m5l5wz cord-271298-7vk3wgw1 cord-021453-vf8xbaug cord-256015-tt58n0jk cord-266571-qbskh1uu cord-033791-q0wizf2n cord-257654-8u9m1k5q cord-280821-kc0ut4oy cord-271180-cnrs0zpg cord-268341-103xf3dw cord-006391-esnsa4u5 cord-274497-tqceazdp cord-033453-557obi3r cord-265891-jmpterrj cord-280242-2w2kl0uf cord-031315-p7jb4gf2 cord-006344-de4dhv4b cord-023100-0pqnsiid cord-005777-6rvfsx4p cord-015090-n6f4xupw cord-283257-rh3bxvv7 cord-268081-ytx6sf3x cord-274860-7ec2jcoq cord-007456-acbo4zs2 cord-018110-mcw4v13c cord-006444-eq56zhtd cord-032806-o6p861ms cord-275427-00bwhaga cord-276338-wpo1eyeg cord-023017-k6edtg58 cord-285096-g9y3au1a cord-266156-xmf4emln cord-258696-01wj76es cord-288051-wp8v2mc5 cord-005816-i54q5gsu cord-292970-32mql9nq cord-275889-4qwp3um1 cord-278224-sq7tokbx cord-287182-f0q8gfzc cord-287520-51kmd2ds cord-282158-08u3x1z4 cord-291315-y40s45iv cord-295086-tc3re52f cord-006856-b1w25ob5 cord-022659-chwk2bs4 cord-277077-kwaiorp8 cord-021555-rrverrsj cord-282268-f7mbdfr6 cord-295367-xhdki8jn cord-007064-nepgttxf cord-285812-l7dpv6nx cord-295633-vkjcheaz cord-300570-xes201g7 cord-015126-cyhcbk1j cord-295703-no45mgyd cord-014538-6a2pviol cord-005646-xhx9pzhj cord-299343-gsrgf4dd cord-306705-adshd3jj cord-309588-kw4d32dt cord-005478-5iu38pr6 cord-015024-2xzc0uc5 cord-014976-546zaoxn cord-006182-kck5e1ry cord-275828-c6d6nk7x cord-015369-72cjogxz cord-304562-5xh4p786 cord-314235-08z2jyzd cord-006880-9dgmdtj8 cord-014464-m5n250r2 cord-310249-cvv77f10 cord-303878-v2n9jeeb cord-301947-b6nwaost cord-300810-a1skdp67 cord-324553-qd8249w3 cord-005497-w81ysjf9 cord-005727-li8pwigg cord-326143-6ndqgxy8 cord-317347-by8albr9 cord-305365-50uojtet cord-330414-yh58ya39 cord-318994-1xngjndu cord-324345-j43rpvwk cord-331347-imexhlwn cord-334667-0cah15lg cord-319933-yp9ofhi8 cord-337454-0h28a3az cord-343789-6tq0kcfd cord-327045-hn8pmcto cord-347716-ka2lm62r cord-006870-f5w6fw6q cord-335490-p63qlcnx cord-333522-zsdymkjd cord-337129-6wt6wzxv cord-347140-q8qis03p cord-350024-whne0l19 cord-336000-v88bq4bx cord-343349-ftzjdvfj cord-346836-6jyv0q5e cord-349329-f0pbd968 cord-335975-m6lkrehi cord-341063-3rqnu5bu cord-006849-vgjz74ts cord-355038-o2hr5mox cord-023095-4dannjjm cord-005814-ak5pq312 cord-015021-pol2qm74 cord-010119-t1x9gknd cord-005460-ezrn8cva cord-005453-4057qib7 Creating transaction Updating ent table ===== Reducing parts of speech cord-000705-w52dc97h cord-000059-5hwqdnx1 cord-001192-zbogocki cord-003533-8m0vyxq8 cord-002659-566uoozj cord-000097-vueo83vk cord-007288-lzxi6q1p cord-002957-gw2cow0d cord-001262-8s7g2wvd cord-010130-28bt3x25 cord-163587-zjnr7vwm cord-032240-xswtx940 cord-002945-29nj4f05 cord-034257-kl2ccmz5 cord-007178-h0ordzm9 cord-224211-6lsvjfqb cord-027811-vk3qnumx cord-018239-n7axd9bq cord-027259-f4sgobcz cord-009772-pzxvicee cord-271298-7vk3wgw1 cord-266183-uzuda3ir cord-256015-tt58n0jk cord-033791-q0wizf2n cord-266571-qbskh1uu cord-257654-8u9m1k5q cord-280821-kc0ut4oy cord-271180-cnrs0zpg cord-280242-2w2kl0uf cord-268341-103xf3dw cord-274497-tqceazdp cord-265891-jmpterrj cord-030957-45tc5ksf cord-006344-de4dhv4b cord-007456-acbo4zs2 cord-023100-0pqnsiid cord-283257-rh3bxvv7 cord-268081-ytx6sf3x cord-015389-vwgai4k9 cord-031315-p7jb4gf2 cord-274860-7ec2jcoq cord-032806-o6p861ms cord-033453-557obi3r cord-029112-u507i0t0 cord-275427-00bwhaga cord-292970-32mql9nq cord-266156-xmf4emln cord-276338-wpo1eyeg cord-285096-g9y3au1a cord-258696-01wj76es cord-288051-wp8v2mc5 cord-287182-f0q8gfzc cord-295086-tc3re52f cord-275889-4qwp3um1 cord-287520-51kmd2ds cord-282158-08u3x1z4 cord-278224-sq7tokbx cord-018110-mcw4v13c cord-291315-y40s45iv cord-282268-f7mbdfr6 cord-007064-nepgttxf cord-285812-l7dpv6nx cord-277077-kwaiorp8 cord-295367-xhdki8jn cord-295633-vkjcheaz cord-015090-n6f4xupw cord-295703-no45mgyd cord-300570-xes201g7 cord-306705-adshd3jj cord-304562-5xh4p786 cord-310249-cvv77f10 cord-021453-vf8xbaug cord-309588-kw4d32dt cord-326143-6ndqgxy8 cord-314235-08z2jyzd cord-006391-esnsa4u5 cord-299343-gsrgf4dd cord-301947-b6nwaost cord-300810-a1skdp67 cord-303878-v2n9jeeb cord-324553-qd8249w3 cord-006444-eq56zhtd cord-317347-by8albr9 cord-305365-50uojtet cord-330414-yh58ya39 cord-318994-1xngjndu cord-324345-j43rpvwk cord-331347-imexhlwn cord-335490-p63qlcnx cord-006876-v2m5l5wz cord-006856-b1w25ob5 cord-333522-zsdymkjd cord-327045-hn8pmcto cord-337454-0h28a3az cord-334667-0cah15lg cord-343789-6tq0kcfd cord-337129-6wt6wzxv cord-347716-ka2lm62r cord-347140-q8qis03p cord-350024-whne0l19 cord-343349-ftzjdvfj cord-005777-6rvfsx4p cord-346836-6jyv0q5e cord-349329-f0pbd968 cord-022659-chwk2bs4 cord-336000-v88bq4bx cord-275828-c6d6nk7x cord-023017-k6edtg58 cord-319933-yp9ofhi8 cord-014976-546zaoxn cord-015126-cyhcbk1j cord-021555-rrverrsj cord-014538-6a2pviol cord-005646-xhx9pzhj cord-005478-5iu38pr6 cord-005816-i54q5gsu cord-015369-72cjogxz cord-006880-9dgmdtj8 cord-015024-2xzc0uc5 cord-006182-kck5e1ry cord-014464-m5n250r2 cord-005727-li8pwigg cord-005497-w81ysjf9 cord-335975-m6lkrehi cord-341063-3rqnu5bu cord-006870-f5w6fw6q cord-355038-o2hr5mox cord-023095-4dannjjm cord-015021-pol2qm74 cord-005814-ak5pq312 cord-006849-vgjz74ts cord-010119-t1x9gknd cord-005460-ezrn8cva cord-005453-4057qib7 Creating transaction Updating pos table Building ./etc/reader.txt cord-005453-4057qib7 cord-006870-f5w6fw6q cord-005497-w81ysjf9 cord-005453-4057qib7 cord-005460-ezrn8cva cord-005497-w81ysjf9 number of items: 134 sum of words: 3,900,342 average size in words: 29,325 average readability score: 51 nouns: patients; study; days; group; results; day; blood; treatment; time; cells; patient; cell; disease; data; mortality; years; age; cases; risk; analysis; infection; care; methods; therapy; groups; levels; months; rate; hospital; outcome; use; surgery; period; transplantation; dose; survival; response; studies; diagnosis; failure; injury; admission; number; case; ml; hours; control; donor; score; factors verbs: used; including; shown; performed; compared; associated; increased; receiving; followed; treating; evaluate; developed; found; reported; observed; reduced; based; underwent; identified; requiring; assess; determine; occur; presenting; measured; related; improved; decreased; died; suggesting; remained; induced; considered; admitted; provide; analyzed; collected; caused; obtained; demonstrated; given; studied; resulting; defined; detecting; needing; describe; according; made; lead adjectives: clinical; acute; high; significant; severe; median; first; higher; non; respiratory; mean; positive; low; different; early; lower; normal; surgical; cardiac; post; medical; total; common; chronic; intensive; negative; specific; primary; patient; anti; septic; pulmonary; new; similar; old; single; initial; retrospective; major; overall; multiple; important; laparoscopic; human; mechanical; renal; immune; postoperative; poor; second adverbs: also; significantly; however; respectively; well; prior; critically; therefore; often; even; still; previously; especially; statistically; later; retrospectively; frequently; clinically; usually; recently; less; highly; currently; alone; approximately; commonly; prospectively; mainly; least; potentially; immediately; daily; furthermore; successfully; particularly; now; first; moreover; subsequently; finally; generally; initially; directly; independently; early; mechanically; rapidly; relatively; overall; already pronouns: we; our; it; their; its; they; i; them; he; she; his; her; us; my; itself; one; you; themselves; me; him; mrs; your; himself; herself; s; myself; iicas; mg; em; rad5; ours; itma; cha; ourselves; oneself; theirs; thee; rrt; pm.sec-; p=0.0007; igg4; ; ≥65; ≥151; αat; yourself; wi~; tv/; tsd; trs\3 proper nouns: ICU; HSCT; mg; GVHD; II; kg; CI; CT; T; C; Hospital; CMV; University; ±; CSF; IV; ARDS; SCT; HLA; Care; A; L; OS; G; TBI; CD34; LPS; January; B; ICH; RBC; AML; TNF; PCR; Group; der; Background; ICP; HCV; Fig; IL-6; M; ATG; GvHD; Study; MRI; SAH; S; COVID-19; AKI keywords: day; patient; study; group; icu; result; cell; method; care; hospital; covid-19; conclusion; ards; university; january; treatment; mortality; intensive; high; csf; tbi; sars; vap; sofa; introduction; icp; case; blood; apache; pcr; iqr; hsct; gcs; ecmo; animal; mri; level; increase; hla; disease; cmv; aml; aki; table; peep; outcome; niv; lps; infection; ifn one topic; one dimension: patients file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387643/ titles(s): Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic three topics; one dimension: patients; day; patients file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103238/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150219/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091844/ titles(s): Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting | Biology and Diseases of Ruminants: Sheep, Goats, and Cattle | Physicians – Poster Session five topics; three dimensions: patients icu study; patients blood patient; patients cell cells; patients dogs surgery; day patients cells file(s): https://doi.org/10.1186/s13613-017-0345-7, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453180/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091844/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103189/, https://www.ncbi.nlm.nih.gov/pubmed/33086508/ titles(s): Proceedings of Réanimation 2018, the French Intensive Care Society International Congress | The politics of precarity | Physicians – Poster Session | 50th Annual Meeting of the Austrian Society of Surgery. Vienna, June 18–20, 2009. Guest Editors: Albert Tuchmann, Erhard Schwanzer, Benedikt Walzel | Use of Yoghurt Enhanced with Volatile Plant Oils Encapsulated in Sodium Alginate to Increase the Human Body’s Immunity in the Present Fight Against Stress Type: cord title: keyword-day-cord date: 2021-05-24 time: 23:21 username: emorgan patron: Eric Morgan email: emorgan@nd.edu input: keywords:day ==== make-pages.sh htm files ==== make-pages.sh complex files ==== make-pages.sh named enities ==== making bibliographics id: cord-295703-no45mgyd author: ALTAY, O. title: Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 date: 2020-10-05 words: 3977.0 sentences: 231.0 pages: flesch: 50.0 cache: ./cache/cord-295703-no45mgyd.txt txt: ./txt/cord-295703-no45mgyd.txt summary: Combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and L-carnitine tartrate is being studied for the treatment of patients with COVID-19. CONCLUSIONS In patients with mild-to-moderate COVID-19, CMCS resulted in a significant reduction in recovery time and liver enzymes associated with hepatic function compared to placebo. Recently, we performed integrative analysis of multi-omics data on different metabolic conditions and found that combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and Lcarnitine tartrate may be used for treatment of the patients with non-alcoholic fatty liver diseases (11, 12) . In this randomized, open-label, placebo-controlled, phase 2 trial involving ambulatory COVID-19 patients, we found that the combination of CMCS and hydroxychloroquine significantly reduced the average recovery time compared with hydroxychloroquine and placebo (6.6 days vs 9.3 days, respectively). abstract: BACKGROUND The characteristics of COVID-19 outbreak and high fatality rate of COVID-19 infection have attracted the attention of scientists due to the strong interactions between components of metabolic syndrome, metabolic abnormalities, and viral pathobiology of COVID-19. Combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and L-carnitine tartrate is being studied for the treatment of patients with COVID-19. METHODS We conducted a placebo-controlled, phase-2 clinical trial involving ambulatory COVID-19 patients. A total of 100 patients were randomly assigned on a 3:1 basis to hydroxychloroquine plus CMCS or hydroxychloroquine plus placebo. The total treatment period for the hydroxychloroquine was 5 days, and for the CMCS/placebo was 14 days. Clinical status was evaluated daily by phone, using a binomial scale for subject reported presence or absence for multiple COVID-19 related symptoms. Plasma samples for clinical chemistry analyses were collected on day 0 and day 14. RESULTS A total of 93 patients completed the trial. The combination of CMCS and hydroxychloroquine significantly reduced the average complete recovery time compared with hydroxychloroquine and placebo (6.6 days vs 9.3 days, respectively). Moreover, there was a significant reduction in ALT, AST and LDH levels on day 14 compared to day 0 in the hydroxychloroquine plus CMCS group. The adverse effects were uncommon and self-limiting. CONCLUSIONS In patients with mild-to-moderate COVID-19, CMCS resulted in a significant reduction in recovery time and liver enzymes associated with hepatic function compared to placebo. We observed that CMSC is associated with a low incidence of adverse events. url: http://medrxiv.org/cgi/content/short/2020.10.02.20202614v1?rss=1 doi: 10.1101/2020.10.02.20202614 id: cord-330414-yh58ya39 author: Agarwal, Deepak K. title: Catheter Removal on the Same Day of Holmium Laser Enucleation of the Prostate: Outcomes of a Pilot Study date: 2020-10-10 words: 2600.0 sentences: 148.0 pages: flesch: 47.0 cache: ./cache/cord-330414-yh58ya39.txt txt: ./txt/cord-330414-yh58ya39.txt summary: title: Catheter Removal on the Same Day of Holmium Laser Enucleation of the Prostate: Outcomes of a Pilot Study OBJECTIVES: To determine if same day catheter removal is feasible in select population after holmium laser enucleation of the prostate (HoLEP). For patients who successfully passed their voiding trial, the median time from the end of the procedure to hospital discharge was 2.6 hours (IQR (2.1-2.9) and from the end of the HoLEP to catheter removal was 4.9 hours (IQR 3.5-6.0). Patients who were not offered same day catheter removal were those with prostate volumes >250 ml on preoperative imaging study (all were required to have imaging to be considered). The rate of passage of voiding trial on the same day as surgery is also similar to recent studies, 11, 12 demonstrating there is no added risk to patient of catheter reinsertion after BPH procedures. abstract: OBJECTIVES: To determine if same day catheter removal is feasible in select population after holmium laser enucleation of the prostate (HoLEP). METHODS: We performed an analysis of patients undergoing HoLEP at our institution who underwent same-day catheter removal after HoLEP. All HoLEPs were performed with Moses Optimized for BPH. Patients were dismissed from postoperative recovery unit (POCU) to the clinic for catheter removal and voiding trial. RESULTS: To date, 30 patients have undergone same day catheter removal. Median age is 68.6 years (IQR 61.8-73.3) and preoperative prostate volume 81 ml (IQR 53-114.8). Median enucleation time was 39.5 min (IQR 30.5-53), morcellation time was 5 min (IQR 4-12 min) and enucleated specimen weight was 52.5 g (IQR 33-81). 27 (90%) patients successfully voided on the same day without requiring catheter replacement. All patients were catheter free by POD1. For patients who successfully passed their voiding trial, the median time from the end of the procedure to hospital discharge was 2.6 hours (IQR (2.1-2.9) and from the end of the HoLEP to catheter removal was 4.9 hours (IQR 3.5-6.0). CONCLUSIONS: We present for the first time that same day catheter removal is a feasible option in a select population of patients undergoing HoLEP. With more study, this has the potential for transforming the management of BPH, especially larger glands. url: https://api.elsevier.com/content/article/pii/S0090429520312425 doi: 10.1016/j.urology.2020.09.038 id: cord-343789-6tq0kcfd author: Al-Tawfiq, Jaffar A. title: Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study date: 2014-01-06 words: 2625.0 sentences: 153.0 pages: flesch: 59.0 cache: ./cache/cord-343789-6tq0kcfd.txt txt: ./txt/cord-343789-6tq0kcfd.txt summary: title: Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study RESULTS: All patients were critically ill with acute respiratory distress syndrome treated with adjunctive corticosteroids and were on mechanical ventilation at the time of initiation of therapy. Since the discovery of Middle East respiratory syndrome coronavirus (MERS-CoV), the virus has caused 163 cases of disease, with a fatality rate of 43-50%. In a recent review, based on therapies used for the related severe acute respiratory syndrome (SARS) coronavirus, the possible use of interferon and ribavirin was considered as a therapeutic option. 8 The purpose of this study was to describe the outcome of the use of a combination of interferon-a2b and ribavirin in the management of five patients with MERS-CoV infections. 20 In a rhesus macaque model of MERS-CoV infection, the combination of interferon-a2b and ribavirin therapy was effective in limiting the disease and resulted in very mild radiographic evidence of pneumonia. abstract: BACKGROUND: The Middle East respiratory syndrome coronavirus (MERS-CoV) has been reported to have a high case-fatality rate. Currently, there is no specific therapy or vaccine with proven effectiveness for MERS-CoV infections. METHODS: A combination of ribavirin and interferon therapy was used for the treatment of five MERS-CoV-positive patients. We reviewed the therapeutic schedule and the outcome of these patients. RESULTS: All patients were critically ill with acute respiratory distress syndrome treated with adjunctive corticosteroids and were on mechanical ventilation at the time of initiation of therapy. The median time from admission to therapy with ribavirin and interferon was 19 (range 10–22) days. None of the patients responded to the supportive or therapeutic interventions and all died of their illness. CONCLUSIONS: While ribavirin and interferon may be effective in some patients, our practical experience suggests that critically ill patients with multiple comorbidities who are diagnosed late in the course of their illness may not benefit from combination antiviral therapy as preclinical data suggest. There is clearly an urgent need for a novel effective antiviral therapy for this emerging global threat. url: https://www.sciencedirect.com/science/article/pii/S1201971213003767 doi: 10.1016/j.ijid.2013.12.003 id: cord-163587-zjnr7vwm author: Altmejd, Adam title: Nowcasting Covid-19 statistics reported withdelay: a case-study of Sweden date: 2020-06-11 words: 3508.0 sentences: 225.0 pages: flesch: 62.0 cache: ./cache/cord-163587-zjnr7vwm.txt txt: ./txt/cord-163587-zjnr7vwm.txt summary: In this paper we describe a statistical methodology for nowcasting the epidemic statistics, such as hospitalizations or deaths, and their degrees of uncertainty, based on the daily reported event frequency and the observed distribution pattern of reporting delays. We propose to use the removal method, developed in animal management (Pollock, 1991) , to present an estimate of the actual frequencies at a given day and their uncertainty. To account for this, we allow the estimated proportions of daily reported cases to follow a probability distribution taking into consideration what type of day it is. We propose a Bayesian version of the removal model that assumes an overdispersed binomial distribution for the daily observations of deaths in Sweden in COVID-19. Another limitation is that the model assumes that the number of new reported deaths for a given day cannot be negative, which is not actually true, due to miscount or misclassification of days. abstract: The new corona virus disease -- COVID-2019 -- is rapidly spreading through the world. The availability of unbiased timely statistics of trends in disease events are a key to effective responses. But due to reporting delays, the most recently reported numbers are frequently underestimating of the total number of infections, hospitalizations and deaths creating an illusion of a downward trend. Here we describe a statistical methodology for predicting true daily quantities and their uncertainty, estimated using historical reporting delays. The methodology takes into account the observed distribution pattern of the lag. It is derived from the removal method, a well-established estimation framework in the field of ecology. url: https://arxiv.org/pdf/2006.06840v1.pdf doi: nan id: cord-002945-29nj4f05 author: Ambrose, Rebecca K. title: In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c) date: 2018-01-19 words: 6608.0 sentences: 664.0 pages: flesch: 63.0 cache: ./cache/cord-002945-29nj4f05.txt txt: ./txt/cord-002945-29nj4f05.txt summary: Detection of bovine viral diarrhoea virus 1 subgenotype 1c in extracts from cattle samples using quantitative real time PCR (qPCR). For cattle infected with BVDV-1c strain Trangie, one of the four animals tested positive on Day 2 post-infection, while all the other samples were negative throughout the sampling period (Table 1) . For cattle infected with BVDV-1c strain Trangie, one of the four animals tested positive on Day 2 post-infection, while all the other samples were negative throughout the sampling period (Table 1) . BVDV-1c was not detected via qPCR in the nasal swab or serum samples collected from all animals on Day 21, Day 28, Day 42 and Day 55 post-infection and were deemed to be negative (data not shown). BVDV-1c was not detected via qPCR in the nasal swab or serum samples collected from all animals on Day 21, Day 28, Day 42 and Day 55 post-infection and were deemed to be negative (data not shown). abstract: Bovine viral diarrhoea virus 1 (BVDV-1) is strongly associated with several important diseases of cattle, such as bovine respiratory disease, diarrhoea and haemoragic lesions. To date many subgenotypes have been reported for BVDV-1, currently ranging from subgenotype 1a to subgenotype 1u. While BVDV-1 has a world-wide distribution, the subgenotypes have a more restricted geographical distribution. As an example, BVDV-1 subgenotypes 1a and 1b are frequently detected in North America and Europe, while the subgenotype 1c is rarely detected. In contrast, BVDV-1 subgenotype 1c is by far the most commonly reported in Australia. Despite this, uneven distribution of the biological importance of the subgenotypes remains unclear. The aim of this study was to characterise the in vivo properties of five strains of BVDV-1 subgenotype 1c in cattle infection studies. No overt respiratory signs were reported in any of the infected cattle regardless of strain. Consistent with other subgenotypes, transient pyrexia and leukopenia were commonly identified, while thrombocytopenia was not. The quantity of virus detected in the nasal secretions of transiently infected animals suggested the likelihood of horizontal transmission was very low. Further studies are required to fully understand the variability and importance of the BVDV-1 subgenotype 1c. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874738/ doi: 10.3390/pathogens7010012 id: cord-350024-whne0l19 author: Anderson, Victoria L. title: Choosing the Right Antibiotic in Ambulatory Care date: 2006-11-28 words: 4730.0 sentences: 398.0 pages: flesch: 51.0 cache: ./cache/cord-350024-whne0l19.txt txt: ./txt/cord-350024-whne0l19.txt summary: With the use of a system-based approach, this article defines the most common infections seen in ambulatory care and their most common causative organisms and gives antibiotic options with respect to efficacy, common side effects, and cost. Nurse practitioners can diagnose and manage most of these skin infections; however, in the case of necrotizing fasciitis this is a surgical emergency and requires immediate referral and hospitalization.The following clinical entities most commonly seen in outpatient care are described: cellulitis, impetigo, folliculitis, furuncles and carbuncles, necrotizing fasciitis, paronychia, onychomycoses, lice, scabies, and Lyme disease. GAS is the most common bacterial cause and requires treatment with antibiotics; therefore, the main objective in evaluating a patient in the primary care setting is to identify, rule out, and treat GAS. This section discusses infections of the genitourinary tract, including vaginitis, cervicitis, cystitis, and epididymitis with specific reference to the diagnosis and management of sexually transmitted diseases (STDs). abstract: The goal of this article is to be a quick guide for the nurse practitioner practicing in an ambulatory setting for making the right antibiotic choice for the right infection. With the use of a system-based approach, this article defines the most common infections seen in ambulatory care and their most common causative organisms and gives antibiotic options with respect to efficacy, common side effects, and cost. We provide recommendations for length of therapy and follow-up, as well. url: https://www.sciencedirect.com/science/article/pii/S1555415506006829 doi: 10.1016/j.nurpra.2006.09.009 id: cord-283257-rh3bxvv7 author: Andrejčáková, Zuzana title: Synbiotics suppress the release of lactate dehydrogenase, promote non‐specific immunity and integrity of jejunum mucosa in piglets date: 2015-12-21 words: 4572.0 sentences: 234.0 pages: flesch: 43.0 cache: ./cache/cord-283257-rh3bxvv7.txt txt: ./txt/cord-283257-rh3bxvv7.txt summary: The impact of such additives on the release of lactate dehydrogenase (LDH; spectroscopic and electrophoretic assay), alteration of immunity (index of metabolic activity), jejunum histology (light microscopy), and health of conventional piglets from a problematic breed (monitoring of hematology, consistency and moisture of feces and body temperature) were examined. We found significant decrease in LDH leakage in the blood serum and tissue extracts, indicating better cell membrane integrity in the individual organs of animals. The aim of our study therefore was to examine the effect of synbiotics through flaxseed feed supplementation in combination with Lactobacillus plantarum -Biocenol TM LP96 (CCM 7512) and Lactobacillus fermentum -Biocenol TM LF99 (CCM 7514), on the activity of lactate dehydrogenase (LDH), alteration of immunity, jejunum histology and health of conventional piglets from a problematic breed. abstract: The aim of our experiment was to study how synbiotics are able to deal with the problems of post‐weaning piglets. Lactobacillus plantarum – Biocenol(TM) LP96 (CCM 7512), Lactobacillus fermentum – Biocenol(TM) LF99 (CCM 7514) and flaxseed (rich in n‐3 polyunsaturated fatty acids) were administered to 36 conventional piglets from a problematic breed with confirmed presence of enterotoxigenic Escherichia coli and Coronavirus. The experimental piglets were supplied with probiotic cheeses and crushed flax‐seed in the period starting 10 days before weaning and lasting up to 14 days post‐weaning. Piglets in the control group were supplied only control cheese. The impact of such additives on the release of lactate dehydrogenase (LDH; spectroscopic and electrophoretic assay), alteration of immunity (index of metabolic activity), jejunum histology (light microscopy), and health of conventional piglets from a problematic breed (monitoring of hematology, consistency and moisture of feces and body temperature) were examined. We found significant decrease in LDH leakage in the blood serum and tissue extracts, indicating better cell membrane integrity in the individual organs of animals. Probiotics and flaxseed applied together seem to be a good source of nutrients to improve the immune status and the integrity of jejunum mucosa during infection. © 2015 Japanese Society of Animal Science url: https://doi.org/10.1111/asj.12558 doi: 10.1111/asj.12558 id: cord-331347-imexhlwn author: Anzai, Asami title: Assessing the Impact of Reduced Travel on Exportation Dynamics of Novel Coronavirus Infection (COVID-19) date: 2020-02-24 words: 4470.0 sentences: 235.0 pages: flesch: 55.0 cache: ./cache/cord-331347-imexhlwn.txt txt: ./txt/cord-331347-imexhlwn.txt summary: Data on confirmed cases diagnosed outside China were analyzed using statistical models to estimate the impact of travel reduction on three epidemiological outcome measures: (i) the number of exported cases, (ii) the probability of a major epidemic, and (iii) the time delay to a major epidemic. We aim to estimate reductions in the number of exported cases, probability of an outbreak occurring outside China, and any time delay to a major epidemic that may be gained with these policies. The present study explicitly quantified the epidemiological impact of reduced travel volume to and from China on the transmission dynamics of COVID-19 outside China using simple statistical The solid lines represent the probability of a major epidemic in the counterfactual scenario, i.e., based on the expected number of cases diagnosed in Japan. abstract: The impact of the drastic reduction in travel volume within mainland China in January and February 2020 was quantified with respect to reports of novel coronavirus (COVID-19) infections outside China. Data on confirmed cases diagnosed outside China were analyzed using statistical models to estimate the impact of travel reduction on three epidemiological outcome measures: (i) the number of exported cases, (ii) the probability of a major epidemic, and (iii) the time delay to a major epidemic. From 28 January to 7 February 2020, we estimated that 226 exported cases (95% confidence interval: 86,449) were prevented, corresponding to a 70.4% reduction in incidence compared to the counterfactual scenario. The reduced probability of a major epidemic ranged from 7% to 20% in Japan, which resulted in a median time delay to a major epidemic of two days. Depending on the scenario, the estimated delay may be less than one day. As the delay is small, the decision to control travel volume through restrictions on freedom of movement should be balanced between the resulting estimated epidemiological impact and predicted economic fallout. url: https://www.ncbi.nlm.nih.gov/pubmed/32102279/ doi: 10.3390/jcm9020601 id: cord-334667-0cah15lg author: Arabi, Yaseen M. title: Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial date: 2020-01-03 words: 3833.0 sentences: 204.0 pages: flesch: 51.0 cache: ./cache/cord-334667-0cah15lg.txt txt: ./txt/cord-334667-0cah15lg.txt summary: title: Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial ABSTRACT: The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir and intErferon-β1b) investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant interferon-β1b provided with standard supportive care, compared to placebo provided with standard supportive care, in hospitalized patients with laboratory-confirmed MERS. Baseline characteristics will be presented for the two study groups (Additional file 1: Table S1 ) including age, sex, and body mass index, the presence of co-infections, nosocomial versus community-acquired MERS infection, Acute Physiology and Chronic Health Evaluation (APA-CHE) II scores, Sequential Organ Failure Assessment scores, and the Karnofsky Performance Status Scale score [3] . The MIRACLE trial investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant Interferon-β1b provided with standard supportive care, compared to placebo provided with standard supportive care, in hospitalized patients with laboratory-confirmed MERS. abstract: ABSTRACT: The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir and intErferon-β1b) investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant interferon-β1b provided with standard supportive care, compared to placebo provided with standard supportive care, in hospitalized patients with laboratory-confirmed MERS. The MIRACLE trial is designed as a recursive, two-stage, group sequential, multicenter, placebo-controlled, double-blind randomized controlled trial. The aim of this article is to describe the statistical analysis plan for the MIRACLE trial. The primary outcome is 90-day mortality. The primary analysis will follow the intention-to-treat principle. The MIRACLE trial is the first randomized controlled trial for MERS treatment. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02845843. Registered on 27 July 2016. url: https://www.ncbi.nlm.nih.gov/pubmed/31900204/ doi: 10.1186/s13063-019-3846-x id: cord-018110-mcw4v13c author: Arnold, Andreas title: Inner Ear date: 2010 words: 15854.0 sentences: 980.0 pages: flesch: 46.0 cache: ./cache/cord-018110-mcw4v13c.txt txt: ./txt/cord-018110-mcw4v13c.txt summary: In the case of partial or no remission, prednisolone treatment should be continued orally for 16 days together with gastric proton pump inhibitors and additional haemodilutive/haemorheological infusion therapy together with α-lipoic acid should be administered as described for high-frequency idiopathic sensorineural hearing loss. Acute tinnitus due to noise-induced damage or acoustic trauma of the inner ear, idiopathic sensorineural hearing loss (sudden deafness), acute attack of Ménière''s disease, toxic labyrinthitis, rupture of the round window, perilymphatic fistula of the round or oval window, labyrinthine contusion or fractures of the temporal bone due to head trauma should be treated with a daily dose of 250-500 mg prednisolone intravenously on three consecutive days. abstract: Herpes zoster oticus, herpes zoster cephalicus, Ramsay Hunt syndrome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122903/ doi: 10.1007/978-3-540-68940-9_6 id: cord-275427-00bwhaga author: Aydogdu, Ugur title: The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis date: 2019-11-30 words: 5218.0 sentences: 264.0 pages: flesch: 56.0 cache: ./cache/cord-275427-00bwhaga.txt txt: ./txt/cord-275427-00bwhaga.txt summary: Abstract In this study, it was aimed to investigate the efficacy of chitosan oligosaccharide administrations in different doses of experimental infected lambs with Cryptosporidium parvum. As a result, in lambs with experimental cryptosporidiosis, chitosan oligosaccharide improved in clinical signs and stool character shorter than the positive control group and the administration of chitosan oligosaccharide at doses of 100, 500 and 1000 mg/kg for 7 days significantly reduced oocyst excretion but not enough to remove cryptosporidiosis completely. parvum in in vitro studies, we hypothesized that oral chitosan administration may be used in the treatment of lambs with experimentally cryptosporidiosis. The aim of this study was to determine the treatment efficacy of oral chitosan oligosaccharide in lambs with experimental cryptosporidiosis. According to the findings of this study, the use of chitosan oligosaccharide to be used in the treatment of experimental cryptosporidiosis at doses of 100 and/or 500 mg/kg was found to provide an earlier reduction in oocyst excretion compared to 1000 mg/kg dose. abstract: Abstract In this study, it was aimed to investigate the efficacy of chitosan oligosaccharide administrations in different doses of experimental infected lambs with Cryptosporidium parvum. 32 male lambs were used in the study and the lambs were divided into 4 groups with 8 lambs in each group. Groups 1, 2 and 3, twice a day, were administered chitosan oligosaccharide at a dose of 100, 500, and 1000 mg/kg for 7 days, respectively, with milk replacer. In group 4, lambs with cryptosporidiosis were subjected to normal feeding as control without drug administration. Clinical examinations of lambs were made before treatment (day 0) and on days 1, 3, 5 and 7 after treatment and 5 ml of blood was collected from vena jugularis for blood analysis of all lambs. Weight changes of lambs were recorded at 0, 7, 14, and 21 days. Stool specimens were collected pre-treatment (day 0) and on days 1, 3, 5, 7, 14 and 21 post-treatment to determine oocyst excretion of lambs with cryptosporidiosis. Lambs with a mean oocyte counts >10 after stool examination were included to the treatment. Changes in clinical hematology, blood gases and biochemical parameters were observed during the course of treatment, but these changes were limited. Weight loss was observed at 7th day according to 0th day the lambs with experimental cryptosporidiosis but gradually weight increase was observed at 14th and 21st days and these changes were similar in all groups. Oocyst excretion decreased in all groups during treatment. According to 0th day, there was a significant (p < 0.05) decrease in oocyte excretions in the third day in group 1 and 2, and in day 5 in the group 3 and 4. Significant changes (p < 0.05) were observed in oocyst excretions on the third and fifth days among the groups. As a result, in lambs with experimental cryptosporidiosis, chitosan oligosaccharide improved in clinical signs and stool character shorter than the positive control group and the administration of chitosan oligosaccharide at doses of 100, 500 and 1000 mg/kg for 7 days significantly reduced oocyst excretion but not enough to remove cryptosporidiosis completely. url: https://www.ncbi.nlm.nih.gov/pubmed/32288211/ doi: 10.1016/j.smallrumres.2019.09.021 id: cord-336000-v88bq4bx author: Barco, Stefano title: Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial date: 2020-09-09 words: 20392.0 sentences: 1064.0 pages: flesch: 44.0 cache: ./cache/cord-336000-v88bq4bx.txt txt: ./txt/cord-336000-v88bq4bx.txt summary: OBJECTIVES: The OVID study will demonstrate whether prophylactic-dose enoxaparin improves survival and reduces hospitalizations in symptomatic ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe systemic, pulmonary, and vessel inflammation and coagulation activation. The OVID study will show whether prophylactic-dose enoxaparin improves survival and reduces any hospitalizations in ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe systemic, pulmonary, and vessel inflammation and coagulation activation. <30% of the expected number of patients six months after the enrolment of the first patient, also based on the course of SARS-CoV2 infections in Switzerland;  when the safety of the participants is doubtful or at risk, respectively, based on recommendations received from DSMB committee;  changes in accepted clinical practice that make the continuation of a clinical trial unwise, including the results of similar studies or the publication of international guidances. abstract: OBJECTIVES: The OVID study will demonstrate whether prophylactic-dose enoxaparin improves survival and reduces hospitalizations in symptomatic ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe systemic, pulmonary, and vessel inflammation and coagulation activation. TRIAL DESIGN: The OVID study is conducted as a multicentre open-label superiority randomised controlled trial. PARTICIPANTS: Inclusion Criteria 1. Signed patient informed consent after being fully informed about the study’s background. 2. Patients aged 50 years or older with a positive test for SARS-CoV2 in the past 5 days and eligible for ambulatory treatment. 3. Presence of respiratory symptoms (i.e. cough, sore throat, or shortness of breath) or body temperature >37.5° C. 4. Ability of the patient to travel to the study centre by private transportation, performed either by an accompanying person from the same household or by the patient themselves 5. Ability to comply with standard hygiene requirements at the time of in-hospital visit, including a face mask and hand disinfectant. 6. Ability to walk from car to study centre or reach it by wheelchair transport with the help of an accompanying person from the same household also complying with standard hygiene requirements. 7. Ability to self-administer prefilled enoxaparin injections after instructions received at the study centre or availability of a person living with the patient to administer enoxaparin. Exclusion Criteria 1. Any acute or chronic condition posing an indication for anticoagulant treatment, e.g. atrial fibrillation, prior venous thromboembolism (VTE), acute confirmed symptomatic VTE, acute coronary syndrome. 2. Anticoagulant thromboprophylaxis deemed necessary in view of the patient's history, comorbidity or predisposing strong risk factors for thrombosis: a. Any of the following events occurring in the prior 30 days: fracture of lower limb, hospitalization for heart failure, hip/knee replacement, major trauma, spinal cord injury, stroke, b. previous VTE, c. histologically confirmed malignancy, which was diagnosed or treated (surgery, chemotherapy, radiotherapy) in the past 6 months, or recurrent, or metastatic, or inoperable. 3. Any clinically relevant bleeding (defined as bleeding requiring hospitalization, transfusion, surgical intervention, invasive procedures, occurring in a critical anatomical site, or causing disability) within 30 days prior to randomization or sign of acute bleeding. 4. Intracerebral bleeding at any time in the past or signs/symptoms consistent with acute intracranial haemorrhage. 5. Haemoglobin <8 g/dL and platelet count <50 x 10(9) cells/L confirmed by recent laboratory test (<90 days). 6. Subjects with any known coagulopathy or bleeding diathesis, including known significant liver disease associated with coagulopathy. 7. Severe renal insufficiency (baseline creatinine clearance <30 mL/min calculated using the Cockcroft-Gault formula) confirmed by recent laboratory test (<90 days). 8. Contraindications to enoxaparin therapy, including prior heparin-induced thrombocytopenia and known hypersensitivity. 9. Current use of dual antiplatelet therapy. 10. Participation in other interventional studies over the past 30 days. 11. Non-compliance or inability to adhere to treatment or lack of a family environment or support system for home treatment. 12. Cognitive impairment and/or inability to understand information provided in the study information. Patient enrolment will take place at seven Swiss centres, including five university hospitals and two large cantonal hospitals. INTERVENTION AND COMPARATOR: Patients randomized to the intervention group will receive subcutaneous enoxaparin at the recommended dose of 4,000 IU anti-Xa activity (40 mg/0.4 ml) once daily for 14 days. Patients randomized to the comparator group will receive no anticoagulation. MAIN OUTCOMES: Primary outcome: a composite of any hospitalization or all-cause death occurring within 30 days of randomization. Secondary outcomes: (i) a composite of cardiovascular events, including deep vein thrombosis (including catheter-associated), pulmonary embolism, myocardial infarction/myocarditis, arterial ischemia including mesenteric and extremities, acute splanchnic vein thrombosis, or ischemic stroke within 14 days, 30 days, and 90 days of randomization; (ii) each component of the primary efficacy outcome, within 14 days, 30 days, and 90 days of randomization; (iii) net clinical benefit (accounting for the primary efficacy outcome, composite cardiovascular events, and major bleeding), within 14 days, 30 days, and 90 days of enrolment; (iv) primary efficacy outcome, within 14 days, and 90 days of enrolment; (v) disseminated intravascular coagulation (ISTH criteria, in-hospital diagnosis) within 14 days, 30 days, and 90 days of enrolment. RANDOMISATION: Patients will undergo block stratified randomization (by age: 50-70 vs. >70 years; and by study centre) with a randomization ratio of 1:1 with block sizes varying between 4 and 8. Randomization will be performed after the signature of the informed consent for participation and the verification of the eligibility criteria using the electronic data capture software (REDCAP, Vanderbilt University, v9.1.24). BLINDING (MASKING): In this open-label study, no blinding procedures will be used. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): The sample size calculation is based on the parameters α = 0.05 (2-sided), power: 1−β = 0.8, event rate in experimental group, pexp = 0.09 and event rate in control group, pcon = 0.15. The resulting total sample size is 920. To account for potential dropouts, the total sample size was fixed to 1000 with 500 patients in the intervention group and 500 in the control group. TRIAL STATUS: Protocol version 1.0, 14 April 2020. Protocol version 3.0, 18 May 2020 Recruiting start date: June 2020. Last Patient Last Visit: March 2021. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04400799 First Posted: May 26, 2020 Last Update Posted: July 16, 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. url: https://doi.org/10.1186/s13063-020-04678-4 doi: 10.1186/s13063-020-04678-4 id: cord-000097-vueo83vk author: Beretta, Chiara title: Prolonged extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome in a child affected by rituximab-resistant autoimmune hemolytic anemia: a case report date: 2009-04-01 words: 2841.0 sentences: 153.0 pages: flesch: 42.0 cache: ./cache/cord-000097-vueo83vk.txt txt: ./txt/cord-000097-vueo83vk.txt summary: title: Prolonged extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome in a child affected by rituximab-resistant autoimmune hemolytic anemia: a case report Recently, the use of monoclonal antibodies (rituximab) has allowed sustained remissions to be obtained in the majority of pediatric patients with refractory autoimmune hemolytic anemia. While still on steroid therapy, the patient developed an interstitial pneumonia with Acute Respiratory Distress Syndrome, which required immediate admission to the intensive care unit where extracorporeal membrane oxygenation therapy was administered continuously for 37 days. CONCLUSIONS: This case shows that aggressive combined immunosuppressive therapy may lead to a sustained complete remission in children with refractory autoimmune hemolytic anemia. One month after the end of the first course of rituximab, while still receiving low-dose steroids, the patient presented with a clinical relapse of AIHA, so prednisone was increased to 2mg/kg/day and two further rituximab infusions were performed ( Figure 1 ). abstract: INTRODUCTION: Autoimmune hemolytic anemia in children younger than 2 years of age is usually characterized by a severe course, with a mortality rate of approximately 10%. The prolonged immunosuppression following specific treatment may be associated with a high risk of developing severe infections. Recently, the use of monoclonal antibodies (rituximab) has allowed sustained remissions to be obtained in the majority of pediatric patients with refractory autoimmune hemolytic anemia. CASE PRESENTATION: We describe the case of an 8-month-old Caucasian girl affected by a severe form of autoimmune hemolytic anemia, which required continuous steroid treatment for 16 months. Thereafter, she received 4 weekly doses of rituximab (375 mg/m(2)/dose) associated with steroid therapy, which was then tapered over the subsequent 2 weeks. One month after the last dose of rrituximab, she presented with recurrence of severe hemolysis and received two more doses of rrituximab. The patient remained in clinical remission for 7 months, before presenting with a further relapse. An alternative heavy immunosuppressive therapy was administered combining cyclophosphamide 10 mg/kg/day for 10 days with methylprednisolone 40 mg/kg/day for 5 days, which was then tapered down over 3 weeks. While still on steroid therapy, the patient developed an interstitial pneumonia with Acute Respiratory Distress Syndrome, which required immediate admission to the intensive care unit where extracorporeal membrane oxygenation therapy was administered continuously for 37 days. At 16-month follow-up, the patient is alive and in good clinical condition, with no organ dysfunction, free from any immunosuppressive treatment and with a normal Hb level. CONCLUSIONS: This case shows that aggressive combined immunosuppressive therapy may lead to a sustained complete remission in children with refractory autoimmune hemolytic anemia. However, the severe life-threatening complication presented by our patient indicates that strict clinical monitoring must be vigilantly performed, that antimicrobial prophylaxis should always be considered and that experienced medical and nursing staff must be available, to deliver highly specialized supportive salvage therapies, if necessary, during intensive care monitoring. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726476/ doi: 10.1186/1752-1947-3-6443 id: cord-343349-ftzjdvfj author: Bhatt, P. N. title: Experimental infection of adult axenic rats with Parker''s Rat Coronavirus date: 1977 words: 2128.0 sentences: 131.0 pages: flesch: 51.0 cache: ./cache/cord-343349-ftzjdvfj.txt txt: ./txt/cord-343349-ftzjdvfj.txt summary: Virus was recovered from the nasopharynx and trachea after twenty-four hours and from the lung by day three but was not detected in respiratory tract after seven days. Viral antigen was detected by indirect immunofluorescence in the mucosal epithelium of upper respiratory tract and in pulmonary alveolar septae from day two to six postinoculation. Dacryoadenitis did not occur, sialoadenitis was detected in only three rats and virus was recovered from only one submaxillary salivary gland. Coronavirus infection is common in laboratory rats and two antigenically related viruses, sialodacryoadenitis virus (SDAV) and Parker''s rat coronavirus (PRCV), have been isolated from naturally-infected rats (2, 7) . Virus in lungs, tracheas, nasal washings, salivary glands and lacrimal glands was quantitated for individual rats. Virus was not detected in nasopharynx, trachea and lung a~ter day six and in other tissues after day seven except in ~he submaxillary salivary gland of one rat. abstract: The pathogenesis of Parker's Rat Coronavirus (PRCV) was studied in axenic CD rats. Three to four 9 to 10 week old rats were euthanized daily for eight days after intranasal inoculation. Rats remained free of clinical disease. Virus was recovered from the nasopharynx and trachea after twenty-four hours and from the lung by day three but was not detected in respiratory tract after seven days. Viral antigen was detected by indirect immunofluorescence in the mucosal epithelium of upper respiratory tract and in pulmonary alveolar septae from day two to six postinoculation. Acute rhinitis developed by day two and was associated with mild focal necrosis of respiratory mucosal epithelium. Mild nonsuppurative tracheitis and multifocal interstitial pneumonia appeared by day five and persisted through day eight. Dacryoadenitis did not occur, sialoadenitis was detected in only three rats and virus was recovered from only one submaxillary salivary gland. This experiment indicates that PRCV can be a primary pathogen for the respiratory system of adult rats. In contrast to sialodacryoadenitis (SDA) virus the tropism of PRCV for salivary and lacrimal glands is low. url: https://www.ncbi.nlm.nih.gov/pubmed/907478/ doi: 10.1007/bf01314779 id: cord-349329-f0pbd968 author: Bosteels, Cedric title: Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-05 words: 12411.0 sentences: 618.0 pages: flesch: 45.0 cache: ./cache/cord-349329-f0pbd968.txt txt: ./txt/cord-349329-f0pbd968.txt summary: -Presence of acute hypoxic respiratory failure defined as (either or both)  saturation below 93% on minimal 2 l/min O2  PaO2/FiO2 below 350 -Admitted to specialized COVID-19 ward -Age 18-80 -Male or Female -Willing to provide informed consent Exclusion criteria -Patients with known history of serious allergic reactions, including anaphylaxis, to human granulocyte-macrophage colony stimulating factor such as sargramostim, yeast-derived products, or any component of the product. Study Interventions Confirmed or highly suspect COVID-19 patients with acute hypoxic respiratory failure (saturation below 93% on minimal 2 l/min O2 or PaO2/FiO2 <350) will be randomized to receive sargramostim 125mcg twice daily for 5 days as a nebulized inhalation on top of standard of care (active group), or to receive standard of care treatment (control group). abstract: OBJECTIVES: The hypothesis of the proposed intervention is that Granulocyte-macrophage colony-stimulating factor (GM-CSF) has profound effects on antiviral immunity, and can provide the stimulus to restore immune homeostasis in the lung with acute lung injury post COVID-19, and can promote lung repair mechanisms, that lead to a 25% improvement in lung oxygenation parameters. Sargramostim is a man-made form of the naturally-occurring protein GM-CSF. TRIAL DESIGN: A phase 4 academic, prospective, 2 arm (1:1 ratio), randomized, open-label, controlled trial. PARTICIPANTS: Patients aged 18-80 years admitted to specialized COVID-19 wards in 5 Belgian hospitals with recent (< 2 weeks prior to randomization) confirmed COVID-19 infection and acute respiratory failure defined as a PaO2/FiO2 below 350 mmHg or SpO2 below 93% on minimal 2 L/min supplemental oxygen. Patients were excluded from the trial in case of (1) known serious allergic reactions to yeast-derived products, (2) lithium carbonate therapy, (3) mechanical ventilation prior to randomization, (4) peripheral white blood cell count above 25.000/μL and/or active myeloid malignancy, (5) high dose systemic steroid therapy (> 20 mg methylprednisolone or equivalent), (6) enrolment in another investigational study, (7) pregnant or breastfeeding or (8) ferritin levels > 2000 μg/mL. INTERVENTION AND COMPARATOR: Inhaled sargramostim 125 μg twice daily for 5 days in addition to standard care. Upon progression of disease requiring mechanical ventilation or to acute respiratory distress syndrome (ARDS) and initiation of mechanical ventilator support within the 5 day period, inhaled sargramostim will be replaced by intravenous sargramostim 125 μg/m(2) body surface area once daily until the 5 day period is reached. From day 6 onwards, progressive patients in the active group will have the option to receive an additional 5 days of IV sargramostim, based on the treating physician's assessment. Intervention will be compared to standard of care. Subjects progressing to ARDS and requiring invasive mechanical ventilatory support, from day 6 onwards in the standard of care group will have the option (clinician's decision) to initiate IV sargramostim 125m μg/m(2) body surface area once daily for 5 days. MAIN OUTCOMES: The primary endpoint of this intervention is measuring oxygenation after 5 days of inhaled (and intravenous) treatment through assessment of a change in pretreatment and post-treatment ratio of PaO2/FiO2 and through measurement of the P(A-a)O2 gradient (PAO2= Partial alveolar pressure of oxygen, PaO2=Partial arterial pressure of oxygen; FiO2= Fraction of inspired oxygen). RANDOMISATION: Patients will be randomized in a 1:1 ratio. Randomization will be done using REDCap (electronic IWRS system). BLINDING (MASKING): In this open-label trial neither participants, caregivers, nor those assessing the outcomes will be blinded to group assignment. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): A total of 80 patients with confirmed COVID-19 and acute hypoxic respiratory failure will be enrolled, 40 in the active and 40 in the control group. TRIAL STATUS: SARPAC protocol Version 2.0 (April 15 2020). Participant recruitment is ongoing in 5 Belgian Hospitals (i.e. University Hospital Ghent, AZ Sint-Jan Bruges, AZ Delta Roeselare, University Hospital Brussels and ZNA Middelheim Antwerp). Participant recruitment started on March 26(th) 2020. Given the current decline of the COVID-19 pandemic in Belgium, it is difficult to anticipate the rate of participant recruitment. TRIAL REGISTRATION: The trial was registered on Clinical Trials.gov on March 30(th), 2020 (ClinicalTrials.gov Identifier: NCT04326920) - retrospectively registered; https://clinicaltrials.gov/ct2/show/NCT04326920?term=sarpac&recrs=ab&draw=2&rank=1 and on EudraCT on March 24th, 2020 (Identifier: 2020-001254-22). FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. url: https://www.ncbi.nlm.nih.gov/pubmed/32503663/ doi: 10.1186/s13063-020-04451-7 id: cord-033453-557obi3r author: Bretscher, Lorenzo title: COVID-19 and the Cross-Section of Equity Returns: Impact and Transmission date: 2020-09-24 words: 12205.0 sentences: 945.0 pages: flesch: 67.0 cache: ./cache/cord-033453-557obi3r.txt txt: ./txt/cord-033453-557obi3r.txt summary: Using the first reported case of COVID-19 in a given U.S. county as the event day, we find that firms headquartered in an affected county experience, on average, a 27-bps lower return in the 10-day post-event window. The regression results show that the average daily return of a labor-intensive firm residing in a high intensity county is 1% lower in the 10-day post-event window. To this end, we use analysts'' forecast data from the I/B/E/S database and document that the first reported coronavirus case results in downward revision of earnings estimates of firms located in the same county. Second, and related, a unique advantage of our natural experiment is that it allows us to examine the relative strength of various channels (specifically, the labor supply channel, the uncertainty channel, the government policy channel, and the cash flow news channel) through which the COVID-19 shock affects firm valuations. abstract: Using the first reported case of COVID-19 in a given U.S. county as the event day, we find that firms headquartered in an affected county experience, on average, a 27-bps lower return in the 10-day post-event window. This negative effect nearly doubles in magnitude for firms in counties with a higher infection rate (-50 bps). We test a number of transmission channels. Firms belonging to labor-intensive industries and those located in counties with a large mobility decline have worse stock performance. Firms sensitive to COVID-19-induced uncertainty also exhibit more negative returns. Finally, more negative stock returns are associated with downward revisions in earnings forecasts. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543590/ doi: 10.1093/rapstu/raaa017 id: cord-324553-qd8249w3 author: Cadegiani, F. A. title: An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV Female Trial. date: 2020-10-06 words: 6393.0 sentences: 402.0 pages: flesch: 51.0 cache: ./cache/cord-324553-qd8249w3.txt txt: ./txt/cord-324553-qd8249w3.txt summary: The present study aimed to evaluate the effects of any early pharmacological approach to females diagnosed with COVID-19 before seven days of symptoms, as well as investigate whether HA is an additional risk factor in this population. Materials and methods: Females with symptoms for less than seven days confirmed for COVID-19 through positive real-time polymerase chain reaction (rtPCR-SARS-CoV-2) were classified and divided as non-HA, HA, and HA using spironolactone (HA-spiro) groups. Conclusions: A sensitive, early detection of COVID-19 followed by a pharmaceutical approach with different drug combinations yielded irrefutable differences compared to sex-, age-, body mass index (BMI)-, and disease-matched non-treated controls in terms of clinical outcomes, ethically disallowing placebo-control randomized clinical trials in the early stage of COVID-19 due to the marked improvements. Several different molecules demonstrated in vitro antiviral activity against SARS-CoV-2 and have been proposed as promising therapies for COVID-19 (13) , among which the most attempted drug combinations included azithromycin in the majority of the cases, in association with hydroxychloroquine, ivermectin or nitazoxanide (13, 14) . abstract: Background: While COVID-19 remains largely unclear and mortality continues to raise, early effective approaches prior to complications lack, as well as researches for characterization and therapeutical potential options in actual early COVID-19. Although females seem to be less affected than females, hyperandrogenic (HA) phenotype, like polycystic ovary syndrome (PCOS), idiopathic hirsutism, congenital adrenal hyperplasia (CAH) female androgenetic alopecia (AGA), or idiopathic HA may be at higher risk due to its inherent enhanced androgenic activity. The present study aimed to evaluate the effects of any early pharmacological approach to females diagnosed with COVID-19 before seven days of symptoms, as well as investigate whether HA is an additional risk factor in this population. Materials and methods: Females with symptoms for less than seven days confirmed for COVID-19 through positive real-time polymerase chain reaction (rtPCR-SARS-CoV-2) were classified and divided as non-HA, HA, and HA using spironolactone (HA-spiro) groups. Patients were questioned for baseline characteristics, 23 different diseases, 44 drug classes and vaccines, 28 different symptoms, and eight different parameters to measure COVID-19 related clinical outcomes. Treatment was then provided, including azithromycin 500mg/day for five days in all cases, associated with hydroxychloroquine 400mg/day for five days, nitazoxanide 500mg twice a day for six days, or ivermectin 0.2mg/kg/day por three days, and optionally spironolactone 100mg twice a day until cure. Patients were assessed for COVID-19 clinical course, clinical and viral duration, and disease progression. Results: In total, 270 females were enrolled, including 195, 67, and eight in non-HA, HA, and HA-spiro groups, respectively. Prevailing symptoms were anosmia (71.1%), ageusia (67.0%), headache (48.1%), myalgia (37.4%), dry cough (36.3%), nasal congestion or rhinorrhea (34.1%), fatigue (33.3%), weakness (29.5%), hyporexia (27.8%), thoracic pain (24.8%), diarrhea (24.1%) and dizziness (21.5%). Earliest symptoms (days) were dizziness (1.0 +- 0.2 day), abdominal pain (1.1 +- 0.3); conjunctival hyperemia (1.1 +- 0.5), nasal congestion or rhinorrhea (1.2 +- 0.5), headache (1.2 +- 0.5), dry cough (1.2 +- 61617; 0.5), myalgia (1.2 +- 0.4), nauseas (1.3 +- 0.5) and weakness (1.3 +- 0.5). Time-to-treat, positive rtPCR, and duration of symptoms with and without anosmia and ageusia were significantly lower in HA-spiro than non-HA, HA, and overall non-users. Time-to-treat was similar while all duration of symptoms and positive rtPCR-SARS-CoV-2 were significantly shorter in non-HA than HA. Spironolactone users were more likely to be asymptomatic than non-users during COVID-19. Fewer non-HA than HA females were affected by anosmia, ageusia, dry cough, fatigue, weakness and hyporexia. Ageusia, weakness and myalgia lasted shorter in non-HA than HA. None of the patients needed hospitalization or any other COVID-19 complication. Conclusions: A sensitive, early detection of COVID-19 followed by a pharmaceutical approach with different drug combinations yielded irrefutable differences compared to sex-, age-, body mass index (BMI)-, and disease-matched non-treated controls in terms of clinical outcomes, ethically disallowing placebo-control randomized clinical trials in the early stage of COVID-19 due to the marked improvements. HA females presented more severe and prolonged clinical manifestations, although none progressed to worse outcomes. Spironolactone mitigated the additional risks due to HA. url: https://doi.org/10.1101/2020.10.05.20206870 doi: 10.1101/2020.10.05.20206870 id: cord-292970-32mql9nq author: Camdessanche, Jean-Philippe title: COVID-19 may induce Guillain-Barré syndrome date: 2020-04-15 words: 299.0 sentences: 24.0 pages: flesch: 66.0 cache: ./cache/cord-292970-32mql9nq.txt txt: ./txt/cord-292970-32mql9nq.txt summary: key: cord-292970-32mql9nq title: COVID-19 may induce Guillain-Barré syndrome journal: Rev Neurol (Paris) DOI: 10.1016/j.neurol.2020.04.003 cord_uid: 32mql9nq In the context of COVID-19 pandemic, SARS-CoV-2 RT-PCR on nasopharyngeal swab was performed and positive. Clinical presentation was moderate with high grade fever for three days requiring oxygen 2-3 L/min through nasal cannula for five days. Eleven days after the symptom onset, while he did not need oxygen anymore having had no fever for five days, the patient complained of paresthesia in feet and hands. In three days, he Covid-19 pandemic is a worldwide disaster. Pulmonary disorder and respiratory insufficiency are the main problems linked to SARS-CoV-2 infection, which explains difficulties in ICU to treat numerous patients [2] . questioned the link between COVID-19 and GBS [3] . Our case is the first GBS with a chronology undoubtedly in favor of a complication of COVID-19 infection. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32334841/ doi: 10.1016/j.neurol.2020.04.003 id: cord-287520-51kmd2ds author: Carneiro, Arie title: Impact of the COVID-19 Pandemic on the Urologist’s clinical practice in Brazil: a management guideline proposal for low- and middle-income countries during the crisis period date: 2020-05-20 words: 4537.0 sentences: 282.0 pages: flesch: 49.0 cache: ./cache/cord-287520-51kmd2ds.txt txt: ./txt/cord-287520-51kmd2ds.txt summary: Therefore, most worldwide authorities are recommending to avoid, as much as possible, patient''s elective visits to hospitals, as well as a judicious use of the operating room in order to mitigate the strain put on the health system. If it is not possible to separate an entire surgical block, we suggest designating specific rooms for the care of patients with COVID-19 that will not be used for regular cases. The gold standard test for investigation of the upper urinary tract is uro-tomography, but in times when we need to consider the use of resources, ultrasound could potentially be used since many imaging services are overloaded due to the frequent indication of thoracic CTs for the diagnosis and follow-up of patients with Sars-Cov-2. -In Intermediate-risk and high-risk non--muscle-invasive bladder cancers: Clinically fit patients with no major comorbidities should receive induction therapy followed by at least 1-year maintenance BCG. abstract: This letter to the Editor aims to provide suggestions and recommendations for the management of urological conditions in times of COVID-19 crisis in Brazil and other low- and middle-income countries. It is important to highlight that one of the main characteristics of this pandemic is the oversaturation of the health system capacity, mostly due to a high demand for personal protective equipment (PPE), Hospital/ICU beds, as well as ventilators. In places with limited resources and where the health care systems are already saturated, such consideration is even more worrisome. Therefore, most worldwide authorities are recommending to avoid, as much as possible, patient’s elective visits to hospitals, as well as a judicious use of the operating room in order to mitigate the strain put on the health system. While efforts should be directed to the care of COVID-19 patients, other conditions (especially urgencies and oncological cases) must continue to be assisted. Thus, through a panel of experts, we have prepared a practical guide for urologists based on the recommendations from the main Urologic Associations, as well as data from the literature to support the suggested management. We will try to follow the standard guideline recommendations from the American Urological Association (AUA) and European Association of Urology (EAU), with the aim of pursuing the best outcomes possible. However, some recommendations were based on the consensus of the panel, taking into consideration the reality of developing countries and the unprecedented situation caused by the COVID-19 crisis. url: https://doi.org/10.1590/s1677-5538.ibju.2020.04.03 doi: 10.1590/s1677-5538.ibju.2020.04.03 id: cord-282268-f7mbdfr6 author: Cartenì, Armando title: How mobility habits influenced the spread of the COVID-19 pandemic: Results from the Italian case study date: 2020-06-24 words: 5276.0 sentences: 209.0 pages: flesch: 48.0 cache: ./cache/cord-282268-f7mbdfr6.txt txt: ./txt/cord-282268-f7mbdfr6.txt summary: By contrast, the hypothesis discussed in this research is that the time period (days) in which a new positive case of coronavirus is identified and certified, which could be called a sort of a positivity detection time, is longer than the incubation time because of possible delays between contagion and detection caused, for example, by the significant percentage of tests that prove false negative to COVID-19, or by the fraction of people who, although infected, are asymptomatic and/or initially show only mild symptoms, and therefore do not resort to health care. Estimates were made through a multiple linear regression model linking the number of certified daily cases (day-to-day) to socio-economic indices (e.g. number of residents; population density), environmental variables (e.g. temperature, PM pollution), health care indicators (e.g. number of swabs taken daily) and mobility habits (e.g. number people who performed trips several days before). abstract: Abstract Starting from December 2019 the world has faced an unprecedented health crisis caused by the new Coronavirus (COVID-19) due to the SARS-CoV-2 pathogen. Within this topic, the aim of the paper was to quantify the effect of mobility habits in the spread of the Coronavirus in Italy through a multiple linear regression model. Estimation results showed that mobility habits represent one of the variables that explains the number of COVID-19 infections jointly with the number of tests/day and some environmental variables (i.e. PM pollution and temperature). Nevertheless, a proximity variable to the first outbreak was also significant, meaning that the areas close to the outbreak had a higher risk of contagion, especially in the initial stage of infection (time-decay phenomena). Furthermore, the number of daily new cases was related to the trips performed three weeks before. This threshold of 21 days could be considered as a sort of positivity detection time, meaning that the mobility restrictions quarantine commonly set at 14 days, defined only according to incubation-based epidemiological considerations, is underestimated (possible delays between contagion and detection) as a containment policy and may not always contribute to effectively slowing down the spread of virus worldwide. This result is original and, if confirmed in other studies, will lay the groundwork for more effective containment of COVID-19 in countries that are still in the health emergency, as well as for possible future returns of the virus. url: https://api.elsevier.com/content/article/pii/S0048969720340110 doi: 10.1016/j.scitotenv.2020.140489 id: cord-309588-kw4d32dt author: Chan, Michael H.M. title: Steroid-induced osteonecrosis in severe acute respiratory syndrome: a retrospective analysis of biochemical markers of bone metabolism and corticosteroid therapy date: 2006-06-30 words: 4614.0 sentences: 245.0 pages: flesch: 46.0 cache: ./cache/cord-309588-kw4d32dt.txt txt: ./txt/cord-309588-kw4d32dt.txt summary: Summary Aim We investigated the effect of massive doses of corticosteroid therapy on bone metabolism using specific biochemical markers of bone metabolism, and the prevalence of osteonecrosis in severe acute respiratory syndrome (SARS) patients at a university teaching hospital in Hong Kong. Biochemical markers of bone metabolism were analysed retrospectively using serial clotted blood samples collected from each patient during the course of hospital admission to discharge and subsequent follow-up at out-patient clinic using the arbitrary time periods: (i) Day <10; (ii) Day 28-44; (iii) Day 51-84; and (iv) Day >90 after the onset of fever. Aim: We investigated the effect of massive doses of corticosteroid therapy on bone metabolism using specific biochemical markers of bone metabolism, and the prevalence of osteonecrosis in severe acute respiratory syndrome (SARS) patients at a university teaching hospital in Hong Kong. 9, 10 In this study, biochemical markers of bone metabolism were used retrospectively to investigate the effect of massive doses of pulse and maintenance corticosteroid therapies on patients with SARS. abstract: Summary Aim We investigated the effect of massive doses of corticosteroid therapy on bone metabolism using specific biochemical markers of bone metabolism, and the prevalence of osteonecrosis in severe acute respiratory syndrome (SARS) patients at a university teaching hospital in Hong Kong. Methods Seventy-one patients with a clinical diagnosis of SARS were studied according to the modified World Health Organization case definition of SARS who were involved in the SARS epidemic between 10 March and 20 June 2003. The clinical diagnosis was confirmed by serological test and/ or molecular analysis. Biochemical markers of bone metabolism were analysed retrospectively using serial clotted blood samples collected from each patient during the course of hospital admission to discharge and subsequent follow-up at out-patient clinic using the arbitrary time periods: (i) Day <10; (ii) Day 28-44; (iii) Day 51-84; and (iv) Day >90 after the onset of fever. Magnetic resonance imaging of the knee and hip joints were performed post-admission to evaluate the prevalence of osteonecrosis amongst these SARS patients. Various risk factors for the development of osteonecrosis were assessed using receiver operating characteristics curve comparison with appropriate test statistics and Spearman’s coefficients of rank correlation with biochemical bone markers. Results Biochemical markers of bone metabolism showed significant bone resorption as evidenced by a marked increase in serum C-terminal telopeptide concentration (CTx) from Day 28-44 after the onset of fever. With tapering down of corticosteroid dosage, CTx started to return to previous baseline level from Day 51 onwards, while other bone formation markers, serum osteocalcin and bone- specific alkaline phosphatase concentrations (OC and BALP, respectively), started to increase. The latter effect was even more marked after Day >90. Seven patients developed radiological evidence of osteonecrosis. The prevalence of osteonecrosis in this cohort was 9.9%. A total corticosteroid dosage of >1900mg hydrocortisone, >2000 mg methylprednisolone, >13 340 mg hydrocortisone-equivalent corticosteroid therapy, and >18 days on corticosteroid therapy were found to be significant risk factors for the subsequent development of osteonecrosis. There were also significant positive correlations amongst various biochemical bone markers in this patient cohort. Conclusion Both bone resorption and formation markers were unable to predict the subsequent development of osteonecrosis. The use of high dose of hydrocortisone or methylprednisolone for an extended duration was shown to be a significant risk factor for osteonecrosis. Its prevalence in this cohort is comparable to those reported in the literature for SARS patients with high-dose corticosteroid therapy. The Day 28–44 increase in the serum CTx coincided with the timing of corticosteroid use. The Day >51 increase in serum OC and BALP coincided with the timing of corticosteroid withdrawal. url: https://www.sciencedirect.com/science/article/pii/S003130251633940X doi: 10.1080/00313020600696231 id: cord-337454-0h28a3az author: Chartier, C. title: Prophylaxis using paromomycin of natural cryptosporidial infection in neonatal kids date: 1996-01-31 words: 1704.0 sentences: 98.0 pages: flesch: 61.0 cache: ./cache/cord-337454-0h28a3az.txt txt: ./txt/cord-337454-0h28a3az.txt summary: The first group consisted of 18 kids; of these, nine had been born on 9 February and had been treated with paromomycin; the other nine, born 2 days later were untreated controls. Except for the medicated kid from the second trial, all animals showed a distension of small and large intestines by Table 2 Comparison of cryptosporidial oocyst shedding score in treated ( paromomycin from day 2 to day 13 of age) and untreated kids; trial 2 Moreover, in the first group of animals where control kids were severely affected, paromomycin prevented diarrhea and mortality. At the end of the studies, on days 15-19, oocyst excretions of medicated animals did not differ from those of the controls. Recent studies conducted in calves at 60-120 pg kg-'' for 7 days in experimental conditions (Naciri et al., 1993) should be duplicated in kids in field conditions and compared with the paromomycin prophylaxis schedule in order to define the most effective and convenient way to control cryptosporidiosis in goats. abstract: Abstract The chemoprophylactic effects of paromomycin sulfate against natural cryptosporidiosis in young kids were investigated. Two studies were carried out using two groups of 18 and 12 animals in two pens. In each pen, kids were allocated to treated or control groups. The treatment consisted of oral paromomycin given at 100 mg kg−1 body weight day−1 for 11 consecutive days from 2 days of age. All kids were weighed at 2, 6 and 10 days of age. Infection was monitored by collecting fecal samples and staining fecal smears every 3–4 days from days 4 or 5 to days 15 or 19. The results clearly showed the efficacy of paromomycin in reducing cryptosporidial oocyst output. Moreover, paromomycin prevented clinical signs and mortality. url: https://api.elsevier.com/content/article/pii/0167587795005110 doi: 10.1016/0167-5877(95)00511-0 id: cord-007064-nepgttxf author: Chemaly, Roy F title: A Phase II, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients date: 2019-12-03 words: 5033.0 sentences: 227.0 pages: flesch: 42.0 cache: ./cache/cord-007064-nepgttxf.txt txt: ./txt/cord-007064-nepgttxf.txt summary: title: A Phase II, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients This is the largest randomized, double blind, placebo-controlled clinical trial to date for the treatment of allogeneic and autologous HCT recipients with RSV URTIs. Presatovir treatment did not meet the coprimary endpoints of a greater time-weighted average change in the RSV viral load from Day 1 to 9 and the reduced development of LRTCs through Day 28, but was well tolerated, with a comparable safety profile relative to the placebo. In a post hoc analysis of patients with lymphopenia, the proportion who developed an LRTC through Day 28 was 51% lower following treatment with presatovir, as compared to the placebo; other post hoc analyses also indicated trends toward a treatment effect on LRTCs. The results suggest lessons for the design of future clinical trials of drugs for RSV or other respiratory viruses in transplant recipients or other immunocompromised patients. abstract: BACKGROUND: Hematopoietic-cell transplant (HCT) recipients are at risk for severe respiratory syncytial virus (RSV) infection. We evaluated the RSV fusion inhibitor presatovir in a randomized, double-blind, Phase II trial in HCT recipients with RSV upper respiratory tract infections. METHODS: Patients were stratified by lymphopenia (<200/µL) and ribavirin use; were randomized, stratified by lymphopenia (<200/μL) and ribavirin use, to receive oral presatovir at 200 mg or a placebo on Days 1, 5, 9, 13, and 17, and were followed through Day 28. The coprimary efficacy endpoints were the time-weighted average change in the nasal RSV viral load between Days 1 and 9 and the proportion of patients developing lower respiratory tract complications (LRTCs) through Day 28. RESULTS: From 23 January 2015 to 16 June 2017, 189 patients were randomly assigned to treatment (96 to presatovir and 93 to the placebo). Presatovir treatment, compared with the placebo treatment, did not significantly affect (prespecified α = 0.01) a time-weighted average decline in the RSV viral load from Day 1 to 9 (treatment difference, −0.33 log(10) copies/mL; 95% confidence interval [CI] −.64 to −.02 log(10) copies/mL; P = .040) or the progression to LRTC (11.2% vs 19.5%, respectively; odds ratio, 0.50; 95% CI, .22–1.18; P = .11). In a post hoc analysis among patients with lymphopenia, presatovir decreased LRTC development by Day 28 (2/15 [13.3%] vs 9/14 [64.3%], respectively; P = .008), compared with the placebo. Adverse events were similar for patients receiving presatovir and the placebo. CONCLUSIONS: Presatovir had a favorable safety profile in adult HCT recipients with RSV but did not achieve the coprimary endpoints. Exploratory analyses suggest an antiviral effect among patients with lymphopenia. CLINICAL TRIALS REGISTRATION: NCT02254408; EUDRA-CT#2014-002474-36. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108134/ doi: 10.1093/cid/ciz1166 id: cord-010130-28bt3x25 author: Crocchiolo, R. title: Infections after T‐replete haploidentical transplantation and high‐dose cyclophosphamide as graft‐versus‐host disease prophylaxis date: 2015-03-26 words: 3519.0 sentences: 175.0 pages: flesch: 46.0 cache: ./cache/cord-010130-28bt3x25.txt txt: ./txt/cord-010130-28bt3x25.txt summary: RESULTS: After a median follow‐up of 23 months, cumulative incidence of viral infections was 70% (95% confidence interval [CI] 59–81) at 100 days and 77% (95% CI 67–87) at 1 year; 35 of 65 patients at risk had CMV reactivation (54%) and the rate of polyomavirus‐virus‐associated cystitis was 19% (13/70). In the present analysis, we described infectious complications after unmanipulated, T-cell replete haplo-HSCT using post-transplant Cy in 70 consecutive patients and found, aside from a high incidence of viral infections/reactivations, especially in the early posttransplant period, a quite low incidence of late bacterial infections, together with a very low incidence of IFIs after day +180 (2 events in the overall 11 observed). In conclusion, the present single-center data on 70 consecutive patients receiving T-cell replete haplo-HSCT with post-transplant Cy confirm a high rate of viral infections before day +100 and a lower incidence of infections afterward, suggesting a satisfactory although non-optimal immune reconstitution after this type of transplantation. abstract: BACKGROUND: Recently, a platform of T‐cell replete haploidentical hematopoietic stem cell transplantation (haplo‐HSCT) using post‐transplant cyclophosphamide (Cy) has shown high reproducibility and acceptable safety profile. METHOD: This prospective cohort analysis allowed us to collect data on infections among 70 consecutive recipients of haplo‐HSCT affected by various hematologic malignancies. RESULTS: After a median follow‐up of 23 months, cumulative incidence of viral infections was 70% (95% confidence interval [CI] 59–81) at 100 days and 77% (95% CI 67–87) at 1 year; 35 of 65 patients at risk had CMV reactivation (54%) and the rate of polyomavirus‐virus‐associated cystitis was 19% (13/70). Cumulative incidence of bacterial and fungal infections at 1 year were 63% (95% CI 51–75) and 12% (95% CI 4–19), respectively. Of note, only 1 invasive fungal infection occurred beyond 1 year after transplant (day +739). CONCLUSION: In conclusion, despite a high rate of viral infections in the early period, present data suggest a satisfactory infectious profile after T‐cell replete haplo‐HSCT using post‐transplant Cy. These results may help clinicians to improve both prophylactic and therapeutic antimicrobial strategies in this emerging haploidentical setting. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169814/ doi: 10.1111/tid.12365 id: cord-258696-01wj76es author: Decaro, Nicola title: Experimental infection of dogs with a novel strain of canine coronavirus causing systemic disease and lymphopenia date: 2008-04-30 words: 3428.0 sentences: 177.0 pages: flesch: 61.0 cache: ./cache/cord-258696-01wj76es.txt txt: ./txt/cord-258696-01wj76es.txt summary: The dogs, three 2.5-month-old and two 6-month-old pups, were successfully infected, shedding viral RNA with their faeces for the entire observation period (21 days) and displaying systemic clinical signs resembling those observed during the course of natural infection. At postmortem examination, remarkable lesions were observed in the internal organs of the euthanized pups, that tested positive for CCoV by real-time RT-PCR and virus isolation on cell cultures. Unexpectedly, CCoV type II RNA was detected at very high titres in the internal organs of the dead pups and the virus (strain CB/05) was isolated on canine cell cultures. (last day of observation) reaching the maximal mean value of 6.79 Â 10 5 RNA copy numbers/ml of template at day 10 p.i. Surprisingly, CCoV RNA was never detected in the blood of the 6-month-old pups, as well as in the euthanized animals, in whose organs remarkable viral RNA titres were found. abstract: A pantropic canine coronavirus (CCoV) strain (CB/05) has been recently associated to a fatal outbreak of systemic disease in young dogs. We report the clinical, virological and serological findings in dogs experimentally infected with strain CB/05. The dogs, three 2.5-month-old and two 6-month-old pups, were successfully infected, shedding viral RNA with their faeces for the entire observation period (21 days) and displaying systemic clinical signs resembling those observed during the course of natural infection. Leucopenia (acute lymphopenia) occurred in all infected dogs, with values dropping below 60% of the initial counts. Considering the severity of the CB/05-induced disease, two of the youngest pups were euthanized for ethical reasons at days 8–9 postinfection, whereas the other pups underwent a slow but progressive improvement of their clinical status with complete recovery. At postmortem examination, remarkable lesions were observed in the internal organs of the euthanized pups, that tested positive for CCoV by real-time RT-PCR and virus isolation on cell cultures. All pups seroconverted for CCoV, as shown by the high optical density values and antibody titres detected by ELISA and virusneutralisation tests, respectively. The present study confirms that strain CB/05 is highly pathogenic for dogs, being able to induce a severe disease (and in some cases the death) even in experimental conditions. url: https://www.sciencedirect.com/science/article/pii/S0378113507005172 doi: 10.1016/j.vetmic.2007.10.008 id: cord-021555-rrverrsj author: Delano, Margaret L. title: Biology and Diseases of Ruminants: Sheep, Goats, and Cattle date: 2007-09-02 words: 71765.0 sentences: 5075.0 pages: flesch: 49.0 cache: ./cache/cord-021555-rrverrsj.txt txt: ./txt/cord-021555-rrverrsj.txt summary: These references also provide information regarding vaccination products licensed for use in ruminants and typical herd and flock vaccination parasite control schedules ("Current Veterinary Therapy," 1986 , 1999 "Council report," 1994; "Large Animal Internal Medicine," 1996; Smith and Sherman, 1994) When designing a vaccination program during qualification of a source or at the research facility, it is important to evaluate the local disease incidence and the potential for exposure. Clinical signs in chronic cases in older animals, such as adult goats, include soft stools, weight loss, anorexia, depression, and severe diarrhea, sometimes with mucus and blood. This pathogen does present a complication due to the carrier status of some animals, the likelihood of herd outbreaks, the severity of disease in younger animals, and the morbidity, possible progression to uveitis, and time and treatment costs associated with infections. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150219/ doi: 10.1016/b978-012263951-7/50017-x id: cord-347140-q8qis03p author: Dietz, Thomas title: Earth Day: 50 Years of Continuity and Change in Environmentalism date: 2020-04-17 words: 2463.0 sentences: 146.0 pages: flesch: 49.0 cache: ./cache/cord-347140-q8qis03p.txt txt: ./txt/cord-347140-q8qis03p.txt summary: The first Earth Day took place on April 22 in the midst of this instability, and its campaigns and the environmental movement it birthed were inevitably influenced by the politics of the time. Although the event was heavily influenced by the US politics of the time, from an environmental perspective Earth Day crystallized the convergence of several themes that would define environmentalism for the decades that followed. In the case of climate change, although the proportion of the public who are concerned has increased over the last decade, a strong ideological split between Democrats and Republicans persists. Thus, as in 1970, we need to find ways to link scientific analysis to political action and overcome the polarization that has shaped and defined environmentalism in the US for the past half-century. Political polarization and long-term change in public support for environmental spending abstract: In April 1970, the first Earth Day engaged millions of people in thousands of events around the US. Those events reflected the emergence of a new form of environmentalism. Many of the themes present 50 years ago persist, but in the US environmental issues have become more politically polarized, and it is unclear whether such value conflicts will persist in the future. url: https://www.sciencedirect.com/science/article/pii/S2590332220301548 doi: 10.1016/j.oneear.2020.04.003 id: cord-021453-vf8xbaug author: Dysko, Robert C. title: Biology and Diseases of Dogs date: 2007-09-02 words: 41994.0 sentences: 2688.0 pages: flesch: 48.0 cache: ./cache/cord-021453-vf8xbaug.txt txt: ./txt/cord-021453-vf8xbaug.txt summary: The use of dogs continued as biomedical research advanced, and they were featured in many noteworthy studies, including those by Pavlov to observe and document the conditioned reflex response and by Banting and Best to identify the role of insulin in diabetes mellitus. Especially noted in this chapter are infectious diseases associated with the use of random-source dogs that have unknown vaccination history and have had intensive contact with other similar animals at pounds and/or shelters, or conditions seen frequently in the beagle, the most common breed used in biomedical research. Culture requires selective isolation media, and growth is favored by reduced oxygen tension and a temperature of 42~ Any disorder that can cause diarrhea in dogs should be considered as a differential diagnosis, including canine parvovirus, coronavirus, distemper virus, Giardia, and Salmonella infections; helminth infestations; and hemorrhagic gastroenteritis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149775/ doi: 10.1016/b978-012263951-7/50014-4 id: cord-305365-50uojtet author: Easson, Will title: A review of rabbit and rodent production medicine date: 2001-07-31 words: 5416.0 sentences: 316.0 pages: flesch: 57.0 cache: ./cache/cord-305365-50uojtet.txt txt: ./txt/cord-305365-50uojtet.txt summary: This review article outlines the essentials of production medicine (factors affecting production colony output) in rabbits and rodents, emphasizing the importance of routine management methods and record-keeping as well as disease control. Dystocia is not a common problem in rabbits, but when seen it is usually caused by obesity, a large fetus (particularly in small litters), or malpresentation. Infertility can be caused by the following factors: obesity; nutritional deficiencies; metritis; high environmental temperatures (>29~ poor lighting (low intensity or <10 hours/day); disease (eg, respiratory infection, skin mites, gastrointestinal disease, cystic ovaries); overcrowding; aged boars or sows; and mechanical impediments (eg, sawdust or the waxy secretion boars accumulate in their groin and scrotal regions). It is caused by the energy requirements of the last stages of gestation and of increasing lactation, particularly in primiparous obese sows that become anorexic for any reason (eg, any stress or disease) or who have a low-energy diet in this critical month. abstract: This review article outlines the essentials of production medicine (factors affecting production colony output) in rabbits and rodents, emphasizing the importance of routine management methods and record-keeping as well as disease control. Common management regimes and production diseases of the important rodent species are covered. url: https://api.elsevier.com/content/article/pii/S1055937X01800050 doi: 10.1053/saep.2001.24252 id: cord-265891-jmpterrj author: Eilersen, Andreas title: Cost–benefit of limited isolation and testing in COVID-19 mitigation date: 2020-10-29 words: 3925.0 sentences: 233.0 pages: flesch: 56.0 cache: ./cache/cord-265891-jmpterrj.txt txt: ./txt/cord-265891-jmpterrj.txt summary: Therefore, we will here implement a crude form of contact tracing where we (1) close the workplaces of people who are tested positive for the disease, (2) isolate their regular social contacts for a limited period, and (3) keep symptomatic individuals in quarantine until they recover. If 10% efficiency is possible, corresponding to detecting about a third of infectious cases, then peak height could be reduced by a factor of almost three with to a 60% drop, if the probability of infected people being tested is only 10% per day of illness. In Fig. 4 , we show two possible scenarios where testing and contact tracing is implemented after a 30-day lockdown with a 75% reduction of the work and social spheres. Using reasonable COVID-19 infection parameters we find that the 1STQ strategy can contribute to epidemic mitigation, in the sense that it can reduce the peak number of infected individuals by about a factor of two even with a realistic testing rate of 10% per day of illness. abstract: The international community has been put in an unprecedented situation by the COVID-19 pandemic. Creating models to describe and quantify alternative mitigation strategies becomes increasingly urgent. In this study, we propose an agent-based model of disease transmission in a society divided into closely connected families, workplaces, and social groups. This allows us to discuss mitigation strategies, including targeted quarantine measures. We find that workplace and more diffuse social contacts are roughly equally important to disease spread, and that an effective lockdown must target both. We examine the cost–benefit of replacing a lockdown with tracing and quarantining contacts of the infected. Quarantine can contribute substantially to mitigation, even if it has short duration and is done within households. When reopening society, testing and quarantining is a strategy that is much cheaper in terms of lost workdays than a long lockdown. A targeted quarantine strategy is quite efficient with only 5 days of quarantine, and its effect increases when testing is more widespread. url: https://www.ncbi.nlm.nih.gov/pubmed/33122753/ doi: 10.1038/s41598-020-75640-2 id: cord-007178-h0ordzm9 author: Felts, Paul A. title: Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide date: 2005-05-04 words: 9492.0 sentences: 425.0 pages: flesch: 47.0 cache: ./cache/cord-007178-h0ordzm9.txt txt: ./txt/cord-007178-h0ordzm9.txt summary: At this interval the lesion was clearly discernible using differential interference contrast optics as a region of tissue disruption in the dorsal funiculus, allowing AdPC-positive cells to be counted in both demyelinated and apparently normal areas of the dorsal funiculus of LPS-injected animals. Spinal cords injected with saline ( Fig. 1) showed damage restricted to a very small number of axons undergoing either Table 1 Populations of inflammatory cells present in the spinal cord at various times following the injection of LPS or saline into the dorsal funiculus Wallerian degeneration or demyelination. The cells were often adjacent to large blood vessels, and they formed only a small subset of the substantial population of ED1-positive Fig. 7 Light micrographs showing GFAP immunoreactivity at the interface between the dorsal funiculus (DF) and the grey matter (GM) in an animal 7 days after the injection of LPS into the spinal cord. abstract: Inflammation is a prominent feature of several disorders characterized by primary demyelination, but it is not clear whether a relationship exists between inflammation and myelin damage. We have found that substantial demyelination results from the focal inflammatory lesion caused by the injection of lipopolysaccharide (LPS; 200 ng) directly into the rat dorsal funiculus. Within 24 h, such injections caused a focal inflammatory response consisting of a substantial number of polymorphonuclear cells and ED1-positive and inducible nitric oxide synthase (iNOS)-positive macrophages/microglia. The number of inflammatory cells was substantially reduced by day 7. OX-52-positive T-cells were less frequently observed but were present in the meninges at 8 h, reached a maximum in the dorsal funiculus at 7 days, and were rare at 14 days. The inflammation was followed by the appearance of a large lesion of primary demyelination that encompassed up to ∼75% of the cross-sectional area of the dorsal funiculus. Treatment with dexamethasone significantly reduced the number of cells expressing iNOS, but did not prevent the demyelination. By 28 days the lesions were largely remyelinated, usually by Schwann cells. These changes were not observed in control, saline-injected animals. We conclude that the intraspinal injection of LPS results in inflammation and subsequently in prominent demyelination. The mechanisms underlying the demyelination are not clear, but it is notable that it typically begins with disruption of the adaxonal myelin. Indeed, there is an early loss of myelin-associated glycoprotein within the lesion, despite the persistence of proteolipid protein. This combination is a feature of the pattern III lesion recently described in multiple sclerosis (Lucchinetti et al., 2000), and we therefore suggest that LPS-induced demyelination may serve as the first experimental model available for the study of this type of multiple sclerosis lesion. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109778/ doi: 10.1093/brain/awh516 id: cord-032806-o6p861ms author: Fenin, Audrey title: Very low birth weight infants receive full enteral nutrition within 2 postnatal weeks date: 2020-09-29 words: 3977.0 sentences: 180.0 pages: flesch: 53.0 cache: ./cache/cord-032806-o6p861ms.txt txt: ./txt/cord-032806-o6p861ms.txt summary: STUDY DESIGN: Very low birth weight infant cohort admitted in the first postnatal day and categorized as either Epoch 1 or Epoch 2, 12 months before and after implementation of a revised feeding protocol were compared. Despite the lack of difference in 2-year outcomes including survival without moderate or severe neurodevelopmental disability in this trial [9] , neonatal care centers may still find benefit if more rapid advancement of enteral feeds is associated with two common quality indicators in neonatal care-early discontinuation of central venous lines (CVL) and shorter duration of parenteral nutrition (PN), while maintaining infant growth. Therefore, this cohort study, with a retrospective control, was performed with a primary aim to determine if infants were able to reach the full enteral nutrition goal and with secondary aims to determine whether this outcome was associated with changes in PN exposure, CVL days, or growth. abstract: OBJECTIVE: Identify whether an enteral nutrition goal of reaching full feeds by 7 postnatal days for infants 1–1.5 kg and by 14 postnatal days for infants <1 kg was feasible and its associated outcomes. STUDY DESIGN: Very low birth weight infant cohort admitted in the first postnatal day and categorized as either Epoch 1 or Epoch 2, 12 months before and after implementation of a revised feeding protocol were compared. RESULT: In Epoch 2, 83% infants born 1–1.5 kg and 77% infants born <1 kg reached full feeds by 7 and 14 days compared to 26% and 25%, respectively in Epoch 1 (p < 0.0001). Central line and parental nutrition days were significantly lower in Epoch 2 compared to Epoch 1 with sustained and potentially improved infant growth. CONCLUSION: An evidence-based advancement feeding protocol was associated with achieving full feeds within the first 2 postnatal weeks for very low birth weight infants. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522453/ doi: 10.1038/s41372-020-00819-4 id: cord-027811-vk3qnumx author: Freedberg, Daniel E. title: Impact of Fiber-Based Enteral Nutrition on the Gut Microbiome of ICU Patients Receiving Broad-Spectrum Antibiotics: A Randomized Pilot Trial date: 2020-06-11 words: 3836.0 sentences: 201.0 pages: flesch: 50.0 cache: ./cache/cord-027811-vk3qnumx.txt txt: ./txt/cord-027811-vk3qnumx.txt summary: title: Impact of Fiber-Based Enteral Nutrition on the Gut Microbiome of ICU Patients Receiving Broad-Spectrum Antibiotics: A Randomized Pilot Trial CONCLUSIONS: Enteral fiber was associated with nonsignificant trends toward increased relative abundance of short-chain fatty acid–producing bacteria and increased short-chain fatty acid levels among ICU patients receiving broad-spectrum IV antibiotics. This pilot study was designed to test the hypothesis that fiber-based enteral nutrition increases the levels of SCFA-producing bacteria and SCFA levels in ICU patients receiving broad-spectrum IV antibiotics, with a goal of generating effect size estimates that could be used as the basis for future studies involving fiber. A study testing 7 days of 7 g/d inulin versus maltodextrin supplementation in 22 ICU adults initiating enteral nutrition found no difference in fecal abundance of Faecalibacterium prausnitzii or Bifidobacteria, or in fecal SCFA levels (24) . abstract: OBJECTIVES: Dietary fiber increases the abundance of bacteria that metabolize fiber into short-chain fatty acids and confers resistance against gut colonization with multidrug-resistant bacteria. This pilot trial estimated the effect of fiber on gut short-chain fatty acid–producing bacteria in the ICU. DESIGN: Randomized, controlled, open label trial. SETTING: Medical ICU. PATIENTS: Twenty ICU adults receiving broad-spectrum IV antibiotics for sepsis. INTERVENTION: 1:1 randomization to enteral nutrition with mixed soy- and oat-derived fiber (14.3 g fiber/L) versus calorie- and micronutrient-identical enteral nutrition with 0 g/L fiber. MEASUREMENTS: Rectal swabs and whole stools were collected at baseline and on study Days 3, 7, 14, and 30. The primary outcome was within-individual change in the cumulative relative abundance of short-chain fatty acid–producing taxa from baseline to Day 3 based on 16S sequencing of rectal swabs. The secondary outcome was Day 3 cumulative short-chain fatty acid levels based on mass spectrometry of whole stools. Analyses were all intent to treat. MAIN RESULTS: By Day 3, the fiber group received a median of 32.1 g fiber cumulatively (interquartile range, 17.6–54.6) versus 0 g fiber (interquartile range, 0–4.0) in the no fiber group. The median within-individual change in short-chain fatty acid producer relative abundance from baseline to Day 3 was +61% (interquartile range −51 to +1,688) in the fiber group versus −46% (interquartile range, −78 to +13) in the no fiber group (p = 0.28). Whole stool short-chain fatty acid levels on Day 3 were a median of 707 μg short-chain fatty acids/g stool (interquartile range, 190–7,265) in the fiber group versus 118 μg short-chain fatty acids/g stool (interquartile range, 22–1,195) in the no fiber group (p = 0.16). CONCLUSIONS: Enteral fiber was associated with nonsignificant trends toward increased relative abundance of short-chain fatty acid–producing bacteria and increased short-chain fatty acid levels among ICU patients receiving broad-spectrum IV antibiotics. Larger studies should be undertaken and our results can be used for effect size estimates. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314333/ doi: 10.1097/cce.0000000000000135 id: cord-002659-566uoozj author: Fujimoto, Yousuke title: Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection date: 2017-08-22 words: 4768.0 sentences: 275.0 pages: flesch: 57.0 cache: ./cache/cord-002659-566uoozj.txt txt: ./txt/cord-002659-566uoozj.txt summary: Cytokine levels and virus titres in bronchoalveolar lavage fluid from mice with and without asthma after A(H1N1)pdm09 or seasonal H1N1 infection were examined. Virus titres in asthma/A(H1N1)pdm09 mice were highest at 3 days post-infection, and decreased by 7 days post-infection, although the levels at this time point were still higher than that in any other group. In the present study, we investigated the sequential changes in intra-tracheal cytokine production, viral loads, and pulmonary inflammation in a mouse model of bronchial asthma during the first 7 days after A(H1N1)pdm09 or seasonal H1N1 influenza infection. In contrast, the levels in control mice increased to 161.4 pg/mL by 3 days post-seasonal virus infection, which were similar to those in asthma/A(H1N1)pdm09 mice (p = 1.00), and these levels were maintained until 7 days post-infection. The notable findings in the present study were the early peak in both IL-6 and TNF-α levels, the high inflammatory cell infiltration in BAL fluids, and the severe pulmonary inflammation at 3 days post-infection in asthmatic/A(H1N1)pdm09 mice. abstract: Asthmatic patients present more rapid progression of respiratory distress after A(H1N1)pdm09 influenza infection than after seasonal infection. Here, we sought to clarify the pathophysiology of early deterioration in asthmatic patients after A(H1N1)pdm09 infection. Cytokine levels and virus titres in bronchoalveolar lavage fluid from mice with and without asthma after A(H1N1)pdm09 or seasonal H1N1 infection were examined. In asthma/A(H1N1)pdm09 mice, IL-6 and TNF-α levels peaked at 3 days post-infection and were higher than those in all other groups. IFN-γ levels in asthma/A(H1N1)pdm09 mice at 3 days post-infection were higher than in all other mice at any time point, whereas at 7 days post-infection, the levels were lowest in asthma/A(H1N1)pdm09 mice. Virus titres in asthma/A(H1N1)pdm09 mice were highest at 3 days post-infection, and decreased by 7 days post-infection, although the levels at this time point were still higher than that in any other group. Histopathological examination showed more inflammatory cell infiltration and lung tissue destruction in the asthma/A(H1N1)pdm09 group than in any other group. The distinct cytokine profiles in A(H1N1)pdm09-infected asthmatic mice indicated excessive inflammation and virus replication within a few days after infection. Thus, bronchial asthma could be a more exacerbating factor for pandemic influenza infection than for seasonal influenza infection. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567326/ doi: 10.1038/s41598-017-08030-w id: cord-009772-pzxvicee author: GRÜNBERG, K. title: Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo date: 2006-04-27 words: 4953.0 sentences: 350.0 pages: flesch: 58.0 cache: ./cache/cord-009772-pzxvicee.txt txt: ./txt/cord-009772-pzxvicee.txt summary: title: Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo Conclusion We conclude that the severity of cold, as induced by experimental RV16 infection, is a determinant of the increase in airway hypersensitivity to histamine in patients with asthma. Since none of these studies was placebo-controlled, it seems mandatory to examine the effect of experimental rhinovirus infection on airway sensitivity to histamine in asthmatic subjects by using such a design. In the present study, we hypothesized that experimental RVI6 colds in atopic asthmatic patients increase airway sensitivity to histamine. During the course of the study, there were no significant effects on baseline FEV| within either the placebo group or in the RVl 6-treated subjects with a mild or severe cold (MANOVA, P -0.99) ( Figure 1 ). Two previous studies on experimental rhinovirus infection in asthma [!3.14| showed small and variable changes in airway hypersensitivity. abstract: Background Asthma exacerbations are closely associated with respiratory virus infections. However, the pathophysiological consequences of such infections in asthma are largely unclear. Objective To examine the effect of rhinovirus 16 (RV16) infection on airway hypersensitivity to histamine. and on interleukin‐8 (IL‐8) in nasal lavage. Objective Twenty‐seven non‐smoking atopic, mildly asthmatic subjects participated in a placebo‐controlled, parallel study. A dose of 0.5–2.9 ± 10(4) TCID50 RV16 or placebo was nasally administered. Cold symptoms were recorded by questionnaire throughout the study. Histamine challenges were performed at entry, and on days 4 and 11 after inoculation. Nasal lavages were obtained at entry, and on days 2 and 9. The response to histamine was measured by PC(20) (changes expressed as doubling doses: DD). IL‐8 levels were obtained by ELISA, and were expressed in ng/ml. Results RV infection was confirmed by culture of nasal lavage and/or by antibody titre rise in each of the RV16‐treated subjects. Among the 19 RV16‐treated subjects, eight developed severe cold symptoms. Baseline FEV(1) did not change significantly during the study in either treatment group (P= 0.99). However, in the RV16‐treated subjects there was a decrease in PC(20) at day 4, which was most pronounced in those with a severe cold (mean change ± SEM: –1.14 ± 0.28 DD, P= 0.01). In addition. IL‐8 levels increased in tbe RV16 group at days 2 and 9 (P < 0.001). The increase in nasal IL‐8 at day 2 correlated significantly with the change in PC(20) at day 4 (r=–0.48, P= 0.04). Conclusion We conclude that the severity of cold, as induced by experimental RV16 infection, is a determinant of the increase in airway hypersensitivity to histamine in patients with asthma. Our results suggest that this may be mediated by an infiammatory mechanism, involving the release of chemokines such as IL‐8. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164827/ doi: 10.1111/j.1365-2222.1997.tb00670.x id: cord-002957-gw2cow0d author: Gray, Darren W. title: DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles date: 2018-04-05 words: 7426.0 sentences: 323.0 pages: flesch: 36.0 cache: ./cache/cord-002957-gw2cow0d.txt txt: ./txt/cord-002957-gw2cow0d.txt summary: The aims of the current study were therefore to assess the performance of Reverse Phase (RP) and Hydrophobic Interaction Liquid Chromatography (HILIC) separation methods for Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) metabolomic profiling of bovine plasma and identify plasma metabolomic markers capable of differentiating between vaccinated and nonvaccinated calves following intranasal challenge with BPI3V. The selected panel of 383 unique AMRTPs (S3 Table) differentiating animals of different vaccination status at various time-points post-BPI3V challenge were deconvoluted to identify parent ion mass, adducts and low energy fragments using low and high energy data (Function 1 and 2 respectively), yielding 26 parent ions for elemental composition determination. The metabolomic profiling performed here in this study on post-BPI3V challenge acquired samples, has identified a unique panel of plasma metabolites which differ between vaccinated and non-vaccinated animals, and significantly are involved in recognised immune response mechanisms. abstract: Bovine Respiratory Disease (BRD) is a major source of economic loss within the agricultural industry. Vaccination against BRD-associated viruses does not offer complete immune protection and vaccine failure animals present potential routes for disease spread. Serological differentiation of infected from vaccinated animals (DIVA) is possible using antigen-deleted vaccines, but during virus outbreaks DIVA responses are masked by wild-type virus preventing accurate serodiagnosis. Previous work by the authors has established the potential for metabolomic profiling to reveal metabolites associated with systemic immune responses to vaccination. The current study builds on this work by demonstrating for the first time the potential to use plasma metabolite profiling to differentiate between vaccinated and non-vaccinated animals following infection-challenge. Male Holstein Friesian calves were intranasally vaccinated (Pfizer RISPOVAL(®)PI3+RSV) and subsequently challenged with Bovine Parainfluenza Virus type-3 (BPI3V) via nasal inoculation. Metabolomic plasma profiling revealed that viral challenge led to a shift in acquired plasma metabolite profiles from day 2 to 20 p.i., with 26 metabolites identified whose peak intensities were significantly different following viral challenge depending on vaccination status. Elevated levels of biliverdin and bilirubin and decreased 3-indolepropionic acid in non-vaccinated animals at day 6 p.i. may be associated with increased oxidative stress and reactive oxygen scavenging at periods of peak virus titre. During latter stages of infection, increased levels of N-[(3α,5β,12α)-3,12-dihydroxy-7,24-dioxocholan-24-yl]glycine and lysophosphatidycholine and decreased enterolactone in non-vaccinated animals may reflect suppression of innate immune response mechanisms and progression to adaptive immune responses. Levels of hexahydrohippurate were also shown to be significantly elevated in non-vaccinated animals from days 6 to 20 p.i. These findings demonstrate the potential of metabolomic profiling to identify plasma markers that can be employed in disease diagnostic applications to both differentially identify infected non-vaccinated animals during disease outbreaks and provide greater information on the health status of infected animals. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886402/ doi: 10.1371/journal.pone.0194488 id: cord-333522-zsdymkjd author: Gruse, Jeannine title: Quercetin Feeding in Newborn Dairy Calves Cannot Compensate Colostrum Deprivation: Study on Metabolic, Antioxidative and Inflammatory Traits date: 2016-01-11 words: 7010.0 sentences: 333.0 pages: flesch: 46.0 cache: ./cache/cord-333522-zsdymkjd.txt txt: ./txt/cord-333522-zsdymkjd.txt summary: Blood samples were taken repeatedly to measure plasma concentrations of flavonols, glucose, lactate, total protein, albumin, urea, non-esterified fatty acids, triglycerides, cholesterol, insulin, glucagon, cortisol, immunoglobulins, fibrinogen, haptoglobin and serum amyloid A. Basal blood samples were taken before the morning feeding on days 1, 2, 4 and 7 from the jugular vein using evacuated tubes containing either potassium-EDTA (1.2-2 mg/mL EDTA) for analyses of plasma metabolites, insulin, glucagon, immunoglobulins and acute-phase proteins or Li-heparin (12-30 IU heparin) for the determination of the cortisol and flavonol concentrations and the antioxidative status in the plasma. Feed intake, body temperature, heart and respiratory rate and plasma concentrations of metabolites, hormones, flavonols and markers of antioxidative status were analyzed by repeated measurement ANOVA using the MIXED procedure of SAS/STAT software and a model with the fixed factors diet, quercetin and day of life (repeated variable) and all interactions between the fixed factors. abstract: Immaturity of the neonatal immune system is causative for high morbidity in calves and colostrum intake is crucial for acquiring passive immunity. Pathogenesis is promoted by reactive oxygen species accumulating at birth if counter-regulation is inadequate. The flavonol quercetin exerts antioxidative and anti-inflammatory effects that may enhance neonatal health. The aim of this work was to study effects of quercetin feeding on metabolic, antioxidative and inflammatory parameters in neonatal calves to investigate whether quercetin could compensate for insufficient colostrum supply. Twenty-eight newborn calves were assigned to two dietary groups fed colostrum or milk-based formula on day 1 and 2 and milk replacer thereafter. From day 2 onwards, 7 calves per diet group were additionally fed quercetin aglycone (50 mg/(kg body weight × day)). Blood samples were taken repeatedly to measure plasma concentrations of flavonols, glucose, lactate, total protein, albumin, urea, non-esterified fatty acids, triglycerides, cholesterol, insulin, glucagon, cortisol, immunoglobulins, fibrinogen, haptoglobin and serum amyloid A. Trolox equivalent antioxidative capacity, ferric reducing ability of plasma, thiobarbituric acid reactive species and F2-isoprostanes were analyzed to evaluate plasma antioxidative status. Expression of tumor necrosis factor, interleukin-1α, interleukin-1β, serum amyloid A, haptoglobin, fibrinogen, C-reactive protein, catalase, glutathione peroxidase and superoxide dismutase mRNA were measured in liver tissue on day 8. Plasma flavonol concentrations were detectable only after quercetin-feeding without differences between colostrum and formula feeding. Plasma glucose, lactate, total protein, immunoglobulins, triglycerides, cholesterol, trolox equivalent antioxidative capacity and thiobarbituric acid reactive species were higher after colostrum feeding. Body temperature, fecal fluidity and plasma concentrations of cortisol and haptoglobin were higher in formula- than in colostrum-fed groups. Hepatic mRNA expression of tumor necrosis factor was higher after quercetin feeding and expression of C-reactive protein was higher after formula feeding. Data confirm that colostrum improves neonatal health and indicate that quercetin feeding cannot compensate for insufficient colostrum supply. url: https://www.ncbi.nlm.nih.gov/pubmed/26752173/ doi: 10.1371/journal.pone.0146932 id: cord-275889-4qwp3um1 author: Guarnieri, M. title: Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats date: 2017-04-09 words: 6861.0 sentences: 354.0 pages: flesch: 55.0 cache: ./cache/cord-275889-4qwp3um1.txt txt: ./txt/cord-275889-4qwp3um1.txt summary: The intended label dose of 0.65 mg/kg, which provides 2-3 days of clinically significant blood levels of drug, was established in bioequivalence trials and efficacy studies to be described using male and female rats. In the single-dose phase of the trials, 4 groups of 8 rats (4 male, 4 female) were dosed after surgery (described below) with 0.0 (vehicle control), 1.3 (2x), 3.9 (6x), or 6.5 (10x) mg/kg drug suspension of buprenorphine on day 0. In the repeat-dose trials, 4 groups of 8 rats (4 male, 4 female) were dosed after surgery with the vehicle control or drug suspensions containing 1.3, 3.9, or 6.5 mg/kg of buprenorphine on day 0 and following anesthesia on days 4 and 8. Male and female rats were provided with a single dose of drug and sampled at time intervals from 8 hours to 9 days to measure blood concentrations of buprenorphine. abstract: A Target Animal Safety protocol was used to examine adverse events in male and female Fischer F344/NTac rats treated with increasing doses of a subcutaneous implant of a lipid suspension of buprenorphine. A single injection of 0.65 mg/kg afforded clinically significant blood levels of drug for 3 days. Chemistry, hematology, coagulation, and urinalysis values with 2- to 10-fold excess doses of the drug-lipid suspension were within normal limits. Histopathology findings were unremarkable. The skin and underlying tissue surrounding the drug injection were unremarkable. Approximately 25% of a cohort of rats given the excess doses of 1.3, 3.9, and 6.5 mg/kg displayed nausea-related behavior consisting of intermittent and limited excess grooming and self-gnawing. These results confirm the safety of cholesterol-triglyceride carrier systems for subcutaneous drug delivery of buprenorphine in laboratory animals and further demonstrate the utility of lipid-based carriers as scaffolds for subcutaneous, long-acting drug therapy. url: https://www.ncbi.nlm.nih.gov/pubmed/28492060/ doi: 10.1155/2017/3102567 id: cord-268081-ytx6sf3x author: Guionie, Olivier title: An experimental study of the survival of turkey coronavirus at room temperature and +4°C date: 2013-04-22 words: 4051.0 sentences: 195.0 pages: flesch: 55.0 cache: ./cache/cord-268081-ytx6sf3x.txt txt: ./txt/cord-268081-ytx6sf3x.txt summary: As TCoV does not induce lesions in the embryo, virus replication in the jejunum and ileum of the embryos was detected 4 days post inoculation, using RNA extraction and a real-time reverse transcriptase-polymerase chain reaction based on the nucleocapsid gene. However, infectious virus was still detected after 20 days storage at the cooler temperatures, a finding that suggests prolonged survival of Fr TCoV and easier transmission between poultry farms in a cool environment are possible. The first duplicates harvested after different times of storage at the different temperatures were used to test for the presence of residual infectious virus in the sample by inoculating SPF embryonated turkey eggs as described above. However, when the same samples were inoculated into embryonated SPF turkey eggs, viral RNA was detected in the digestive tracts of the inoculated embryos after 0 days of storage (27.5 Ct), but not after 42 or 40 days ( 40 Ct) at room temperature or ''48C, respectively. abstract: Turkey coronavirus (TCoV) is a gammacoronavirus (Coronaviridae, Nidovirales) responsible for digestive disorders in young turkeys. TCoV has been associated with poult enteritis complex, a syndrome that severely affects turkey production. No medical prophylaxis exists to control TCoV, therefore sanitary measures such as cleaning and disinfection are essential. It is thus important to evaluate temperatures that allow persistence of TCoV in the environment. Two series of aliquots of a suspension of a French isolate of TCoV (Fr TCoV) were stored at room temperature or +4°C for 0 to 40 days. As TCoV does not grow in cell culture, the presence of residual infectious TCoV in the stored samples was tested by inoculating embryonated specific pathogen free turkey eggs. As TCoV does not induce lesions in the embryo, virus replication in the jejunum and ileum of the embryos was detected 4 days post inoculation, using RNA extraction and a real-time reverse transcriptase-polymerase chain reaction based on the nucleocapsid gene. No surviving virus was detected after 10 days storage at +21.6±1.4°C or after 40 days storage at +4.1±1.6°C, these temperatures being representative of the mean summer and winter temperatures, respectively, in the major French poultry-producing region. The relatively short survival of the virus at room temperature should contribute to limited virus survival during summer months. However, infectious virus was still detected after 20 days storage at the cooler temperatures, a finding that suggests prolonged survival of Fr TCoV and easier transmission between poultry farms in a cool environment are possible. url: https://doi.org/10.1080/03079457.2013.779364 doi: 10.1080/03079457.2013.779364 id: cord-295633-vkjcheaz author: Hao, Xin‐yan title: The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose‐only exposure device date: 2019-10-30 words: 5108.0 sentences: 255.0 pages: flesch: 50.0 cache: ./cache/cord-295633-vkjcheaz.txt txt: ./txt/cord-295633-vkjcheaz.txt summary: After infection, we analyzed the mouse characteristics of weight loss, survival, viral replication, tissue pathology, viral antigen distribution, and cytokine and chemokine profiles, which provide additional data to investigate the pathogenesis of MERS-CoV-induced disease and evaluate relevant therapeutics and vaccines. Instillation control DMEM suspension To analyze clinical signs, weight loss, and survival On days 3, 5, 7, and 9 postinfection, three animals randomly selected from each group underwent necropsy to obtain tissue specimens for assessing viral distribution, associated histopathology, and cytokine levels using quantitative reverse transcription-PCR (qRT-PCR), hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA). *P < .05, **P < .01, ***P < .001, and ****P < .0001 Mice in the instillation group died acutely or were euthanized when they researched 25% weight loss; these mice had a 0% survival rate by day 5, so no tissue lesion results were available on days 7 and 9 mice infected with MERS-CoV via the aerosol inhalation or intranasal instillation route, but no obvious lesions were found in other tissues. abstract: BACKGROUND: Middle East respiratory syndrome coronavirus (MERS‐CoV), which is not fully understood in regard to certain transmission routes and pathogenesis and lacks specific therapeutics and vaccines, poses a global threat to public health. METHODS: To simulate the clinical aerosol transmission route, hDPP4 transgenic mice were infected with MERS‐CoV by an animal nose‐only exposure device and compared with instillation‐inoculated mice. The challenged mice were observed for 14 consecutive days and necropsied on days 3, 5, 7, and 9 to analyze viral load, histopathology, viral antigen distribution, and cytokines in tissues. RESULTS: MERS‐CoV aerosol‐infected mice with an incubation period of 5‐7 days showed weight loss on days 7‐11, obvious lung lesions on day 7, high viral loads in the lungs on days 3‐9 and in the brain on days 7‐9, and 60% survival. MERS‐CoV instillation‐inoculated mice exhibited clinical signs on day 1, obvious lung lesions on days 3‐5, continuous weight loss, 0% survival by day 5, and high viral loads in the lungs and brain on days 3‐5. Viral antigen and high levels of proinflammatory cytokines and chemokines were detected in the aerosol and instillation groups. Disease, lung lesion, and viral replication progressions were slower in the MERS‐CoV aerosol‐infected mice than in the MERS‐CoV instillation‐inoculated mice. CONCLUSION: hDPP4 transgenic mice were successfully infected with MERS‐CoV aerosols via an animal nose‐only exposure device, and aerosol‐ and instillation‐infected mice simulated the clinical symptoms of moderate diffuse interstitial pneumonia. However, the transgenic mice exposed to aerosol MERS‐CoV developed disease and lung pathology progressions that more closely resembled those observed in humans. url: https://doi.org/10.1002/ame2.12088 doi: 10.1002/ame2.12088 id: cord-276338-wpo1eyeg author: Hesse, Amke title: In toxic demyelination oligodendroglial cell death occurs early and is FAS independent date: 2009-10-22 words: 5481.0 sentences: 288.0 pages: flesch: 48.0 cache: ./cache/cord-276338-wpo1eyeg.txt txt: ./txt/cord-276338-wpo1eyeg.txt summary: During the initial phase of the cuprizone diet (days 6 and 10), but not during later stages (day 21), activated caspase 3 can be detected in apoptotic oligodendrocytes, suggesting that caspase 3-independent pathways trigger oligodendroglial cell death in later stages. In line with the notion of continuous oligodendroglial cell death, we found a significant decrease in the number of Nogo-A-positive mature oligodendrocytes in mice fed with cuprizone after 10 (540 ± 187 cells/mm 2 ) and 21 days (17 ± 15 cells/mm 2 ) compared to untreated controls (1797 ± 404 cells/mm 2 ) (Fig. 2b) . The number of apoptotic cells, Nogo-A-positive oligodendrocytes, activated caspase 3-expressing oligodendrocytes, macrophages and astrocytes, as well as the extent of demyelination, was determined on days 4, 6 and 10 and in mice fed with a cuprizone-free diet (controls). In the cuprizone model, apoptotic oligodendrocytes express activated caspase 3, and this is associated with a significant increase of FAS mRNA in the corpus callosum. abstract: Oligodendroglial cell death is a frequent phenomenon of many neurological diseases, e.g. in demyelinating diseases such as multiple sclerosis (MS). The underlying mechanisms are largely unknown. Here, we demonstrate that in the toxic demyelination cuprizone model, oligodendroglial cell death and downregulation of myelin genes start days after initiation of the cuprizone diet and weeks before demyelination is obvious. In early – but not in later – stages, dying oligodendrocytes express activated caspase 3, suggesting a switch from classical apoptotic pathways to caspase 3-independent mechanisms during the course of the cuprizone diet. The expression level of FAS in the corpus callosum, a cell death receptor crucial for oligodendroglial cell death in experimental autoimmune encephalomyelitis (EAE), correlates with the expression of activated caspase 3 in oligodendrocytes. However, mice lacking FAS in oligodendrocytes are not protected against cuprizone-induced oligodendroglial cell death, showing that FAS is dispensable for oligodendroglial cell death in the cuprizone model. url: https://www.sciencedirect.com/science/article/pii/S0969996109003027 doi: 10.1016/j.nbd.2009.10.016 id: cord-346836-6jyv0q5e author: Ikegami, Tetsuro title: The Pathogenesis of Rift Valley Fever date: 2011-05-06 words: 10419.0 sentences: 483.0 pages: flesch: 46.0 cache: ./cache/cord-346836-6jyv0q5e.txt txt: ./txt/cord-346836-6jyv0q5e.txt summary: RVFV infection in humans usually causes a self-limiting, acute and febrile illness; however, a small number of cases progress to neurological disorders, partial or complete blindness, hemorrhagic fever, or thrombosis. This review describes the pathology of RVF in human patients and several animal models, and summarizes the role of viral virulence factors and host factors that affect RVFV pathogenesis. RVFV infection in humans primarily causes a self-limiting febrile illness; however, some patients develop hemorrhagic fever, neurological disorders, or blindness after the febrile period [5, 7, 8] . Inbred rat strains mimic the disparate human response to rift valley fever virus infection Clinical, virological and serological response of the west african dwarf sheep to experimental infection with different strains of rift valley fever virus abstract: Rift Valley fever (RVF) is an emerging zoonotic disease distributed in sub-Saharan African countries and the Arabian Peninsula. The disease is caused by the Rift Valley fever virus (RVFV) of the family Bunyaviridae and the genus Phlebovirus. The virus is transmitted by mosquitoes, and virus replication in domestic ruminant results in high rates of mortality and abortion. RVFV infection in humans usually causes a self-limiting, acute and febrile illness; however, a small number of cases progress to neurological disorders, partial or complete blindness, hemorrhagic fever, or thrombosis. This review describes the pathology of RVF in human patients and several animal models, and summarizes the role of viral virulence factors and host factors that affect RVFV pathogenesis. url: https://www.ncbi.nlm.nih.gov/pubmed/21666766/ doi: 10.3390/v3050493 id: cord-003533-8m0vyxq8 author: Jayathilaka, P. G. N. S. title: An outbreak of leptospirosis with predominant cardiac involvement: a case series date: 2019-03-18 words: 4148.0 sentences: 280.0 pages: flesch: 50.0 cache: ./cache/cord-003533-8m0vyxq8.txt txt: ./txt/cord-003533-8m0vyxq8.txt summary: We present a case series of severe leptospirosis with cardiac involvement observed during a period of one month at Colombo-North Teaching Hospital, Sri Lanka. CASE PRESENTATION: We report here five patients with severe leptospirosis complicated with cardiac involvement, admitted to a single medical ward, Colombo-North Teaching Hospital, Sri Lanka during a one-month period. In this case series, we describe a series of male patients with severe leptospirosis with cardiac involvement, presented to a single medical ward during a period of one month. By day eleven of illness he was completely recovered clinically and full blood count, liver function tests, renal function tests and ECG were normal. Patient was discharged from the ward on day 7 of illness with complete recovery and normal full blood count, renal and liver function tests. Despite adequate fluid resuscitation patient developed shock with low urine output on the same day of admission. abstract: BACKGROUND: Severe leptospirosis is known to cause multi organ dysfunction including cardiac involvement. In the clinical setting with limited resources, high degree of suspicion is needed to diagnose cardiac involvement including myocarditis. Although myocarditis is not reported as a common complication due to lack of diagnostic facilities, there are evidence to support myocarditis is more prevalent in post mortem studies of patients died due to leptospirosis. We present a case series of severe leptospirosis with cardiac involvement observed during a period of one month at Colombo-North Teaching Hospital, Sri Lanka. CASE PRESENTATION: We report here five patients with severe leptospirosis complicated with cardiac involvement, admitted to a single medical ward, Colombo-North Teaching Hospital, Sri Lanka during a one-month period. Out of six suspected leptospirosis patients admitted during that period, five in a raw developed severe leptospirosis with cardiac involvement. In this case series, four patients were confirmed serologically or quantitative PCR and one patient had possible leptospirosis. All patients developed shock during their course of illness. Two patients developed rapid atrial fibrillation. One patient had dynamic T wave changes in ECG and the other two had sinus tachycardia. Two patients had evidence of myocarditis in 2D echocardiogram, whereas other two patients had nonspecific findings and one patient had normal 2D echocardiogram. All five patients had elevated cardiac troponin I titre and it was normalized with the recovery. All five patients developed acute kidney injury. Four patients needed inotropic/vasopressor support to maintain mean arterial pressure and one patient recovered from shock with fluid resuscitation. All patients were recovered from their illness and repeat 2D echocardiograms after recovery did not show residual complications. One patient had serologically proven dengue co-infection with leptospirosis. CONCLUSIONS: Myocarditis and cardiac involvement in leptospirosis may be overlooked due to non-specific clinical findings and co-existing multi-organ dysfunction. Atypical presentation of this case series may be due to micro-geographic variation and unusual outbreak of leptospirosis. Co-infection of dengue with leptospirosis should be considered in managing patients especially in endemic areas. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423826/ doi: 10.1186/s12879-019-3905-7 id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 words: 61068.0 sentences: 3463.0 pages: flesch: 49.0 cache: ./cache/cord-014538-6a2pviol.txt txt: ./txt/cord-014538-6a2pviol.txt summary: Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225389/ doi: 10.1186/s13613-016-0224-7 id: cord-033791-q0wizf2n author: Kavirayani, Akhila title: The Lazarus effect of very high-dose intravenous anakinra in severe non-familial CNS-HLH date: 2020-10-15 words: 614.0 sentences: 50.0 pages: flesch: 29.0 cache: ./cache/cord-033791-q0wizf2n.txt txt: ./txt/cord-033791-q0wizf2n.txt summary: title: The Lazarus effect of very high-dose intravenous anakinra in severe non-familial CNS-HLH Abbreviations: BAL -bronchoalveolar lavage, CRP -C-reactive protein, TRAPS -Tumour necrosis factor receptor-associated periodic syndrome, WCC -white cell count, FHL -Familial Haemophagocytic lymphohistiocytosis IV methyl prednisolone, 1 dose of IV Immunoglobulin, empiric antibiotics and antivirals-IV aciclovir and IV ceftriaxone, switched to meropenem/teicoplanin upon deterioration (doxycycline/clindamycin/co-amoxiclav also administered subsequently with co-trimoxazole/fluconazole prophylaxis) Inotropes for profound hypotension. Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis Benefit of Anakinra in Treating Pediatric Secondary Hemophagocytic Lymphohistiocytosis Successful treatment of severe paediatric rheumatic disease-associated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: case series with 12 patie nts Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome Therapeutic Role of Anakinra, an Interleukin-1 Receptor Antagonist, in the Management of Secondary Hemophagocytic Lymphohistiocytosis/Sepsis/Multiple Organ Dysfunction/Macrophage Activating Syndrome in Critically Ill Children*: Pediatric Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab: Alemtuzumab for Refractory HLH Pediatric CNS-isolated hemophagocytic lymphohistiocytosis abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561319/ doi: 10.1016/s2665-9913(20)30361-1 id: cord-280242-2w2kl0uf author: Kaya, Yildiz title: Transient cortical blindness in COVID-19 pneumonia; a PRES-like syndrome: A case report date: 2020-04-28 words: 767.0 sentences: 57.0 pages: flesch: 46.0 cache: ./cache/cord-280242-2w2kl0uf.txt txt: ./txt/cord-280242-2w2kl0uf.txt summary: It has been reported that, in addition to the respiratory tract infection symptoms, patients can also have neurologic signs and symptoms; like acute cerebrovascular disease, polyneuritis, encephalitis and encephalopathy 2. Brain magnetic resonance imaging (MRI) showed bilateral, especially left occipital, frontal cortical white matter and splenium of corpus callosum T2/Fluid-attenuated inversion recovery (FLAIR) hyperintensities and diffusion restriction in diffusion weighted imaging (DWI) (Figure 2 ) revealing vasogenic edema similar to posterior reversible leucoencephalopathy (PRES). Recent autopsy reports have revealed that, like many viral infections SARS-CoV-2 can cause brain tissue edema and partial neuronal degeneration [3] . Infectious toxic encephalopathy is a reversible brain dysfunction syndrome caused by systemic toxemia, metabolic disorders and hypoxia during the process of acute infection [4] . Although we could not determine the exact ethiology in our case, regulating the blood pressure controlling the vasogenic edema by corticosteroid treatment and controlling the virus related pneumonia have helped fort he recovery of our patient. abstract: nan url: https://api.elsevier.com/content/article/pii/S0022510X20301945 doi: 10.1016/j.jns.2020.116858 id: cord-031315-p7jb4gf2 author: Kong, Qing title: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial date: 2020-09-03 words: 8352.0 sentences: 471.0 pages: flesch: 52.0 cache: ./cache/cord-031315-p7jb4gf2.txt txt: ./txt/cord-031315-p7jb4gf2.txt summary: title: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial The present study aims to evaluate the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations and to investigate whether the short-term (5-days) systemic glucocorticoid therapy is non-inferior to the long-term (9-day) regime. On one hand, a dose of 40 mg prednisone (a common oral systemic glucocorticoid) daily for 5 days has been recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Science Committee Report based on the REDUCE randomized clinical trial since 2015 [24] . We conducted a randomized and placebo-controlled trial enrolling stable COPD patients in 2014, which illustrated that TCM formulas called Bushen Yiqi (BY) formulas can improve the lung function, reduce the frequency of acute exacerbation of COPD, and modulate the HPA axis [35] . abstract: BACKGROUND: Systemic glucocorticoids are effective for the management of chronic obstructive pulmonary disease (COPD) exacerbation but have serious adverse effects. Traditional Chinese medicine (TCM) can bring additional benefits to these patients but has few adverse effects. The present study aims to evaluate the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations and to investigate whether the short-term (5-days) systemic glucocorticoid therapy is non-inferior to the long-term (9-day) regime. METHODS: In this multi-center, randomized, double-blinded trial, eligible inpatients with COPD exacerbation are randomly assigned to four groups (A, B, C, and D). Group A will receive placebo plus 5-day prednisone, group B will receive placebo plus 9-day prednisone, group C will receive JWBY formulas plus 5-day prednisone, and group D will receive JWBY formulas plus 9-day prednisone. The primary outcomes are the time interval to the patient’s next exacerbation during a 180-day following up and the COPD assessment test (CAT) during treatment. Secondary outcomes include lung function, TCM syndrome assessment, laboratory tests, and safety. The changes of the hypothalamic pituitary adrenaline axis (HPA axis) and inflammatory cytokine will be measured as well. DISCUSSION: By demonstrating the advantages of utilizing TCM and an appropriate duration of systemic glucocorticoids, this effectiveness comparison trial will provide new references to physicians on how to improve the management of COPD exacerbation. The results of HPA axis and inflammation cytokine measurements will shed light on the molecular mechanisms and entail further mechanism studies. TRIAL REGISTRATION: www.chictr.org.cn ChiCTR1900023364. Registered on 24 May 2019. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468179/ doi: 10.1186/s13063-020-04669-5 id: cord-300810-a1skdp67 author: Lafay, F. title: Spread of the CVS strain of rabies virus and of the avirulent mutant AvO1 along the olfactory pathways of the mouse after intranasal inoculation date: 1991-07-31 words: 5731.0 sentences: 292.0 pages: flesch: 54.0 cache: ./cache/cord-300810-a1skdp67.txt txt: ./txt/cord-300810-a1skdp67.txt summary: title: Spread of the CVS strain of rabies virus and of the avirulent mutant AvO1 along the olfactory pathways of the mouse after intranasal inoculation Abstract After intranasal instillation in the mouse, rabies virus (CVS strain) selectively infected olfactory receptor cells. On the other hand, other neuronal cells permissive for CVS, such as mitral cells or the anterior olfactory nucleus, are completely free of infection with the mutant, indicating that restriction is related to the ability of AvO1 to penetrate several categories of neurons. The G protein plays a pivotal role in the pathogenicity of the virus because of its interaction with the host cells '' Abbreviations used: AON, anterior olfactory nucleus; CNS, central nervous system; GABA, Gamma aminobutyric acid; HDB, horizontal limb of the diagonal band; HRP, horseradish peroxidase; HSVl, herpes simplex type 1; IPL, internal plexiform layer: LC, locus coeruleus; LD50, lethal dose 50%; LPA. abstract: Abstract After intranasal instillation in the mouse, rabies virus (CVS strain) selectively infected olfactory receptor cells. In the main olfactory bulb (MOB), infection was observed in periglomerular, tufted, and mitral cells and in interneurons located in the internal plexiform layer. Beyond the MOB, CVS spread into the brain along the olfactory pathways. This infection is specific to chains of functionally related neurons but at the death of the animal some nuclei remain uninfected. CVS also penetrated the trigeminal system. The avirulent mutant AvOl, carrying a mutation in position 333 of the glycoprotein, infected the olfactory epithelium and the trigeminal nerve as efficiently as CVS. During the second cycle of infection, the mutant was able to infect efficiently periglomerular cells in the MOB and neurons of the horizontal limb of the diagonal band, which indicates that maturation of infective particles is not affected in primarily infected neuronal cells. On the other hand, other neuronal cells permissive for CVS, such as mitral cells or the anterior olfactory nucleus, are completely free of infection with the mutant, indicating that restriction is related to the ability of AvO1 to penetrate several categories of neurons. From these observations, we concluded that CVS should be able to bind several different receptors to penetrate neurons, while the mutant would be unable to recognize some of them. url: https://api.elsevier.com/content/article/pii/0042682291901452 doi: 10.1016/0042-6822(91)90145-2 id: cord-306705-adshd3jj author: Lenander-Lumikari, Marianne title: Effects of the common cold and intranasal fluticasone propionate treatment on mucosal host defense assessed by human saliva()()() date: 2005-11-04 words: 2899.0 sentences: 169.0 pages: flesch: 55.0 cache: ./cache/cord-306705-adshd3jj.txt txt: ./txt/cord-306705-adshd3jj.txt summary: title: Effects of the common cold and intranasal fluticasone propionate treatment on mucosal host defense assessed by human saliva()()() 11 To extend these findings, this study analyzed salivary flow rate and selected major host antimicrobial components present in whole saliva in patients with the common cold. The purpose of this investigation was to study the effect of a potent topical steroid, fluticasone propionate, on patients with early signs and symptoms of the common cold. Salivary flow rate, innate host defense factors, and total protein content were not affected by the common cold. Salivary flow rate, innate host defense factors, and total protein content were not affected by the common cold. Neither the common cold nor the fluticasone propionate treatment had any effect on the relative amounts of secreted IgG or IgM immunoglobulins. Therefore, the salivary IgA response was probably induced by the viruses, and the treatment of the common cold with fluticasone propionate did not have any negative influence on this defense factor. abstract: Objective. The purpose of this investigation was to study the effect of a potent topical steroid, fluticasone propionate, on patients with early signs and symptoms of the common cold. To characterize the mucosal inflammatory response, salivary defense factors and flow rate in these patients were analyzed. Study Design. Forty patients with symptoms of the common cold were randomized into 2 groups to receive either high-dose fluticasone propionate (100 μg per nostril) or placebo 4 times daily for 6 days. Paraffin-stimulated whole saliva was collected on day 1 (before the onset of medication), day 7 (posttreatment), and day 21 (follow-up). Results. Salivary flow rate, innate host defense factors, and total protein content were not affected by the common cold. IgA increased between day 7 and day 21 (P ≤ .01; Student 2-tailed t test), and the relative proportions of salivary peroxidase and IgA increased on day 7 (P = .01) and day 21 (P = .05). In patients receiving fluticasone, saliva flow rate was lower on day 21 (P ≤ .05) than on days 1 and 7. The innate salivary defense factors were not affected, but IgA increased both on day 7 (P ≤ .001) and on day 21 (P ≤ .001) in comparison with day 1. Conclusions. Of the oral mucosal defense factors, only IgA is activated during the common cold. Intranasally administrated fluticasone propionate does not have a suppressive effect on salivary antimicrobial capacity. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87:695-9) url: https://api.elsevier.com/content/article/pii/S1079210499701630 doi: 10.1016/s1079-2104(99)70163-0 id: cord-324345-j43rpvwk author: Leong, Hoe Nam title: SARS – My personal battle date: 2010-11-19 words: 3111.0 sentences: 219.0 pages: flesch: 70.0 cache: ./cache/cord-324345-j43rpvwk.txt txt: ./txt/cord-324345-j43rpvwk.txt summary: I vividly remember the time when I first saw the index patient with Severe Acute Respiratory Syndrome (SARS) in Singapore. The index patient was admitted to Tan Tock Seng Hospital (TTSH) on Saturday, (1st March 2003), and an infectious disease consult was sought on the following Monday. It was an exceedingly busy day for me as I had to attend to new referrals, run an outpatient clinic, and subsequently draft a clinical summary of these two patients by the early evening. Eventually, the patient''s fever defervesced on day 14 of illness. I wasn''t scheduled to perform the ward round that day, but I returned to visit the patient that Sunday morning. My wife and I telephoned a colleague in Singapore and we concurred to have a full blood count test done at the clinic the next day. My wife eventually joined me when she developed fever at the end of the second day of arrival. With that news, my days as a patient in isolation continued. abstract: It isn’t every day that a doctor becomes a patient. It is more peculiar when it occurs with an unknown mysterious epidemic respiratory illness that kills. Severe acute respiratory syndrome (SARS) gripped the world in 2003, spreading via air-links and throwing the global economy into disarray. As a practicing physician in Singapore, one of the first countries affected, I describe my first-hand account of my battle with this illness, how I acquired this illness in Singapore, and eventually quarantine in Frankfurt am Main, Germany. url: https://doi.org/10.1016/j.tmaid.2010.10.007 doi: 10.1016/j.tmaid.2010.10.007 id: cord-327045-hn8pmcto author: Li, Yao title: Quercetin, Inflammation and Immunity date: 2016-03-15 words: 5360.0 sentences: 292.0 pages: flesch: 40.0 cache: ./cache/cord-327045-hn8pmcto.txt txt: ./txt/cord-327045-hn8pmcto.txt summary: In vitro and some animal models have shown that quercetin, a polyphenol derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory and antiviral activities; as well as attenuating lipid peroxidation, platelet aggregation and capillary permeability. A study demonstrates that quercetin has a direct regulatory effect on basic functional properties of immune cells which may be mediated by the extracellular regulated kinase 2 (Erk2) mitogen-activated protein (MAP) kinase signal pathway in human mitogen-activated PBMC and purified T lymphocytes [54] . Quercetin most likely universally suppresses the accumulation and activation of immune cells, including anti-inflammatory cells, whereas it specifically increased gene expression associated with mitochondrial oxidative phosphorylation in Western diet-induced obese mice. showed that a supplement of 1000 mg of quercetin alone three weeks before, during and two weeks after a three-day period of 3 h of cycling in the winter resulted in a markedly lower incidence of URTI in well-trained subjects in the two weeks after the intensified training, but had no effect on exercise-induced immune dysfunction, inflammation and oxidative stress [76] . abstract: In vitro and some animal models have shown that quercetin, a polyphenol derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory and antiviral activities; as well as attenuating lipid peroxidation, platelet aggregation and capillary permeability. This review focuses on the physicochemical properties, dietary sources, absorption, bioavailability and metabolism of quercetin, especially main effects of quercetin on inflammation and immune function. According to the results obtained both in vitro and in vivo, good perspectives have been opened for quercetin. Nevertheless, further studies are needed to better characterize the mechanisms of action underlying the beneficial effects of quercetin on inflammation and immunity. url: https://doi.org/10.3390/nu8030167 doi: 10.3390/nu8030167 id: cord-287182-f0q8gfzc author: Liao, Ji‐ping title: Severe pneumonia caused by adenovirus 7 in pregnant woman: Case report and review of the literature date: 2016-06-21 words: 2078.0 sentences: 131.0 pages: flesch: 49.0 cache: ./cache/cord-287182-f0q8gfzc.txt txt: ./txt/cord-287182-f0q8gfzc.txt summary: title: Severe pneumonia caused by adenovirus 7 in pregnant woman: Case report and review of the literature We report a rare case of adenoviral pneumonia in a previously healthy pregnant woman at 26(+4) weeks'' gestation. Here, we report a case of severe communityacquired adenoviral pneumonia in a previously healthy pregnant woman who was managed successfully. 5 Previous studies have shown that pregnant women with viral pneumonia, such as influenza A virus subtype H1N1 and severe acute respiratory syndrome (SARS) coronavirus, have a higher mortality rate and higher rates of both intubation and intensive care unit admission than the general population. 1 In addition, increased adverse pregnancy outcomes, such as preterm delivery, low-birthweight infants, spontaneous abortion and fetal death, are higher in pregnant patients with H1N1 pneumonia than those without. A case-controlled study comparing clinical course and outcomes of pregnant and nonpregnant women with severe acute respiratory syndrome abstract: We report a rare case of adenoviral pneumonia in a previously healthy pregnant woman at 26(+4) weeks' gestation. She presented with persistent high fever, cough for 5 days, and developed progressive dyspnea with hypoxemic respiratory failure and bilateral pulmonary infiltrates with pleural effusions. Aggressive supportive care and timely obstetrical management saved the mother and prevented preterm delivery and fetal anomaly. url: https://doi.org/10.1111/jog.13036 doi: 10.1111/jog.13036 id: cord-318994-1xngjndu author: Lier, Audun J. title: Case Report: Disseminated Strongyloidiasis in a Patient with COVID-19 date: 2020-08-14 words: 1966.0 sentences: 130.0 pages: flesch: 42.0 cache: ./cache/cord-318994-1xngjndu.txt txt: ./txt/cord-318994-1xngjndu.txt summary: We report a case of a COVID-19 patient who developed disseminated strongyloidiasis following treatment with high-dose corticosteroids and tocilizumab. Screening for Strongyloides infection should be pursued in individuals with COVID-19 who originate from endemic regions before initiating immunosuppressive therapy. This report describes the clinical features of a case of disseminated strongyloidiasis infection and polymicrobial bacteremia in an individual who received immunosuppressive treatment for COVID-19. 11 Given our patient''s epidemiologic risk factor and development of Gram-negative bacteremia, the clinical diagnosis of disseminated strongyloidiasis was further supported. The initial Strongyloides serology on hospital day 21 was negative, but the repeat was positive on day 38. 8 This case highlights important considerations when using immunosuppressive therapies for COVID-19 treatment, particularly in patients with risk factors for prior Strongyloides infection. Clinical suspicion for disseminated strongyloidiasis should be maintained in patients from endemic areas who develop Gram-negative sepsis or meningitis. abstract: The SARS-CoV-2 virus has emerged and rapidly evolved into a current global pandemic. Although bacterial and fungal coinfections have been associated with COVID-19, little is known about parasitic infection. We report a case of a COVID-19 patient who developed disseminated strongyloidiasis following treatment with high-dose corticosteroids and tocilizumab. Screening for Strongyloides infection should be pursued in individuals with COVID-19 who originate from endemic regions before initiating immunosuppressive therapy. url: https://doi.org/10.4269/ajtmh.20-0699 doi: 10.4269/ajtmh.20-0699 id: cord-291315-y40s45iv author: Logunov, Denis Y title: Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia date: 2020-09-04 words: 5697.0 sentences: 282.0 pages: flesch: 50.0 cache: ./cache/cord-291315-y40s45iv.txt txt: ./txt/cord-291315-y40s45iv.txt summary: title: Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia Primary outcome measures were antigen-specific humoral immunity (SARS-CoV-2-specific antibodies measured by ELISA on days 0, 14, 21, 28, and 42) and safety (number of participants with adverse events monitored throughout the study). INTERPRETATION: The heterologous rAd26 and rAd5 vector-based COVID-19 vaccine has a good safety profile and induced strong humoral and cellular immune responses in participants. These findings of two open, phase 1/2 non-randomised studies of a heterologous prime-boost COVID-19 vaccine based on recombinant adenoviral vectors rAd26-S and rAd5-S show that the vaccine is safe, well tolerated, and induces strong humoral and cellular immune responses in 100% of healthy participants. In our study, despite formation of neutralising antibodies to recombinant adenoviruses after vaccination with rAd26 and rAd5, formation of a humoral immune response to target antigen (SARS-CoV-2 glycoprotein S) in vaccinated volunteers was not affected. abstract: BACKGROUND: We developed a heterologous COVID-19 vaccine consisting of two components, a recombinant adenovirus type 26 (rAd26) vector and a recombinant adenovirus type 5 (rAd5) vector, both carrying the gene for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein (rAd26-S and rAd5-S). We aimed to assess the safety and immunogenicity of two formulations (frozen and lyophilised) of this vaccine. METHODS: We did two open, non-randomised phase 1/2 studies at two hospitals in Russia. We enrolled healthy adult volunteers (men and women) aged 18–60 years to both studies. In phase 1 of each study, we administered intramuscularly on day 0 either one dose of rAd26-S or one dose of rAd5-S and assessed the safety of the two components for 28 days. In phase 2 of the study, which began no earlier than 5 days after phase 1 vaccination, we administered intramuscularly a prime-boost vaccination, with rAd26-S given on day 0 and rAd5-S on day 21. Primary outcome measures were antigen-specific humoral immunity (SARS-CoV-2-specific antibodies measured by ELISA on days 0, 14, 21, 28, and 42) and safety (number of participants with adverse events monitored throughout the study). Secondary outcome measures were antigen-specific cellular immunity (T-cell responses and interferon-γ concentration) and change in neutralising antibodies (detected with a SARS-CoV-2 neutralisation assay). These trials are registered with ClinicalTrials.gov, NCT04436471 and NCT04437875. FINDINGS: Between June 18 and Aug 3, 2020, we enrolled 76 participants to the two studies (38 in each study). In each study, nine volunteers received rAd26-S in phase 1, nine received rAd5-S in phase 1, and 20 received rAd26-S and rAd5-S in phase 2. Both vaccine formulations were safe and well tolerated. The most common adverse events were pain at injection site (44 [58%]), hyperthermia (38 [50%]), headache (32 [42%]), asthenia (21 [28%]), and muscle and joint pain (18 [24%]). Most adverse events were mild and no serious adverse events were detected. All participants produced antibodies to SARS-CoV-2 glycoprotein. At day 42, receptor binding domain-specific IgG titres were 14 703 with the frozen formulation and 11 143 with the lyophilised formulation, and neutralising antibodies were 49·25 with the frozen formulation and 45·95 with the lyophilised formulation, with a seroconversion rate of 100%. Cell-mediated responses were detected in all participants at day 28, with median cell proliferation of 2·5% CD4(+) and 1·3% CD8(+) with the frozen formulation, and a median cell proliferation of 1·3% CD4(+) and 1·1% CD8(+) with the lyophilised formulation. INTERPRETATION: The heterologous rAd26 and rAd5 vector-based COVID-19 vaccine has a good safety profile and induced strong humoral and cellular immune responses in participants. Further investigation is needed of the effectiveness of this vaccine for prevention of COVID-19. FUNDING: Ministry of Health of the Russian Federation. url: https://api.elsevier.com/content/article/pii/S0140673620318663 doi: 10.1016/s0140-6736(20)31866-3 id: cord-295086-tc3re52f author: Lu, Guoguang title: Dynamic changes in routine blood parameters of a severe COVID-19 case date: 2020-05-13 words: 1749.0 sentences: 82.0 pages: flesch: 49.0 cache: ./cache/cord-295086-tc3re52f.txt txt: ./txt/cord-295086-tc3re52f.txt summary: METHODS: We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days. RESULTS: Our study found that the patient''s condition worsened in the first week after admission; white blood cells (WBCs), neutrophils, lymphocytes, monocytes, eosinophils, erythrocytes, hemoglobin, neutrophil lymphocyte ratio (NLR), platelets (PLT) and platelet lymphocyte ratio (PLR) decreased. The number of WBCs, neutrophils, monocytes, eosinophils and lymphocytes increased gradually, and the erythrocyte parameters stopped declining and stabilized in a certain range; CRP decreased rapidly. On the 20th day of admission, the nucleic acid test was negative, WBC, neutrophil, CRP, NLR and PLR decreased gradually, and monocyte, lymphocyte, and eosinophil counts increased. In addition, it should be noted that monocytes and eosinophils were extremely low within 10 days after admission, which might indicate that the patient''s condition was serious, and then gradually recovered to normal. abstract: BACKGROUND: Novel coronavirus infectious disease (COVID-19) has been spreading worldwide, and tracking laboratory indexes during the diagnosis and treatment of patients with severe COVID-19 can provide a reference for patients in other countries and regions. METHODS: We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days. RESULTS: Our study found that the patient’s condition worsened in the first week after admission; white blood cells (WBCs), neutrophils, lymphocytes, monocytes, eosinophils, erythrocytes, hemoglobin, neutrophil lymphocyte ratio (NLR), platelets (PLT) and platelet lymphocyte ratio (PLR) decreased. On the 7th day of admission, the levels of these cells decreased to their lowest values, though the red blood cell distribution width (RDW) and C-reactive protein (CRP) level remained at high values. From 8-14 days of admission, the patient’s condition improved, hypoxemia was corrected, and mechanical ventilation was discontinued. The number of WBCs, neutrophils, monocytes, eosinophils and lymphocytes increased gradually, and the erythrocyte parameters stopped declining and stabilized in a certain range; CRP decreased rapidly. On the 20th day of admission, the nucleic acid test was negative, WBC, neutrophil, CRP, NLR and PLR decreased gradually, and monocyte, lymphocyte, and eosinophil counts increased. Although red blood cells (RBCs) and hemoglobin (Hb) levels continued to decrease, RDW gradually increased, indicating the recovery of hematopoiesis. In addition, it should be noted that monocytes and eosinophils were at extremely low levels within 10 days after admission; the recovery time of eosinophils was approximately 12 days after admission, which was earlier than other parameters, which might be of great value in judging the progress of the disease. CONCLUSIONS: Dynamic changes in routine blood parameters might be helpful for the prognosis of COVID-19 patients and evaluation of the treatment effect. url: https://api.elsevier.com/content/article/pii/S0009898120301881 doi: 10.1016/j.cca.2020.04.034 id: cord-314235-08z2jyzd author: Matzinger, P. title: Strong impact of closing schools, closing bars and wearing masks during the Covid-19 pandemic: results from a simple and revealing analysis date: 2020-09-28 words: 5932.0 sentences: 304.0 pages: flesch: 64.0 cache: ./cache/cord-314235-08z2jyzd.txt txt: ./txt/cord-314235-08z2jyzd.txt summary: This change 10 occurred 15 days after schools closed, 12 days after bars and restaurants closed, and one day before the state lockdown, suggesting that the effect of one or both of the first two policy 15 decisions was to reduce the doubling rate of cases to slightly more half of the original rate. Figure 1C shows the effect of the lockdown in MD, which was followed twelve days later by an 25 additional threefold change in doubling time, from 4.7 to 12.8 days, and similar rate reductions in hospitalizations and deaths with additional lags of 2 and 6 days respectively. The results, demonstrate that, other than full lockdowns, three government interventions had the most impact on the rates of Covid-19 infections: closing schools, closing bars and wearing masks. abstract: Many complex mathematical and epidemiological methods have been used to model the Covid-19 pandemic. Among other results from these models has been the view that closing schools had little impact on infection rates in several countries1. We took a different approach. Making one assumption, we simply plotted cases, hospitalizations and deaths, on a log2 Y axis and a linear date-based X axis, and analyzed them using segmented regression, a powerful method that has largely been overlooked during this pandemic. Here we show that the data fit straight lines with correlation coefficients ranging from 92% - 99%, and that these lines broke at interesting intervals, revealing that school closings dropped infection rates in half, lockdowns dropped the rates 3 to 4 fold, and other actions (such as closing bars and mandating masks) brought the rates even further down. Hospitalizations and deaths paralleled cases, with lags of three to ten days. The graphs, which are easy to read, reveal changes in infection rates that are not obvious using other graphing methods, and have several implications for modeling and policy development during this and future pandemics. Overall, other than full lockdowns, three interventions had the most impact: closing schools, closing bars and wearing masks: a message easily understood by the public. url: http://medrxiv.org/cgi/content/short/2020.09.26.20202457v1?rss=1 doi: 10.1101/2020.09.26.20202457 id: cord-295367-xhdki8jn author: McNally, D. title: Rapid relief of acute sore throat with AMC/DCBA throat lozenges: randomised controlled trial date: 2009-10-22 words: 7328.0 sentences: 336.0 pages: flesch: 57.0 cache: ./cache/cord-295367-xhdki8jn.txt txt: ./txt/cord-295367-xhdki8jn.txt summary: The superior analgesic effects and improvements in functional impairment scores observed with AMC/DCBA throat lozenges translate into pain relief benefits that are clinically meaningful and are thus a suitable OTC treatment option for patients in the self‐management of acute sore throat. The superior analgesic effects and improvements in functional impairment scores observed with AMC ⁄ DCBA throat lozenges translate into pain relief benefits that are clinically meaningful and are thus a suitable OTC treatment option for patients in the self-management of acute sore throat. The primary objective of this study was to determine the analgesic properties of AMC ⁄ DCBA throat lozenges compared with non-medicated lozenges, in patients with sore throat because of URTIs. The secondary objectives were to determine any additional patient benefits provided by active lozenges compared with placebo lozenges, including the effects on functional impairment scores and the type of relief experienced within the mouth. abstract: Aim: As antibiotics are generally not recommended for the treatment of acute sore throat, the availability of clinically efficacious, over‐the‐counter (OTC) treatment alternatives is becoming increasingly important. This study was designed to determine the analgesic properties of amylmetacresol and 2,4‐dichlorobenzyl alcohol (AMC/DCBA) throat lozenges (Strepsils(®)) in the relief of acute sore throat caused by upper respiratory tract infections. Methods: Patients (n = 310) were randomly assigned to receive AMC/DCBA throat lozenges (n = 155) or non‐medicated placebo lozenges (n = 155). After baseline assessments, patients completed three rating assessments at 10 timepoints from 5 to 20 min after first dose. Subsequent lozenges were taken as required, and assessments were made at the end of Day 1, 24 h after first dose, and at the end of Days 2 and 3. Analgesic properties were assessed by comparing severity of throat soreness and sore throat relief ratings. Difficulty in swallowing and functional impairment scores were also assessed. Results: Amylmetacresol/DCBA throat lozenges reduced throat soreness at 5 min after first dose, which persisted for 2 h and was significantly different vs. non‐medicated lozenges at all assessment timepoints for the duration of the 3‐day study. Similar significant effects were observed with sore throat relief, easing of difficulty with swallowing and functional impairment scores. There were no differences in adverse events reported between treatment groups. Conclusion: Amylmetacresol/DCBA throat lozenges provide rapid analgesic effects that last for 2 h, providing ongoing relief long after the lozenge has dissolved. The superior analgesic effects and improvements in functional impairment scores observed with AMC/DCBA throat lozenges translate into pain relief benefits that are clinically meaningful and are thus a suitable OTC treatment option for patients in the self‐management of acute sore throat. url: https://www.ncbi.nlm.nih.gov/pubmed/19849767/ doi: 10.1111/j.1742-1241.2009.02230.x id: cord-027259-f4sgobcz author: Metsker, Oleg title: Stroke ICU Patient Mortality Day Prediction date: 2020-05-23 words: 5328.0 sentences: 204.0 pages: flesch: 42.0 cache: ./cache/cord-027259-f4sgobcz.txt txt: ./txt/cord-027259-f4sgobcz.txt summary: On the basis of the analysis of 12 modern prognostic models from 10 countries we can identify some of the most stable (main) predictors for the causes of intra-hospital mortality: age [16, [20] [21] [22] [23] [24] ; type of stroke [25] ; lesion location [25] ; level of consciousness [11, 20, 23, 25, 26] upon admission; NIHSS stroke severity [10, 21, 22, 24] ; comorbidity [22, 27] , Charlson comorbidity index [23] , Atrial fibrillation [11, 22] , case history Transitor ischemic attack (TIA) [31]; hospital complications (high intracranial pressure) [16] , pneumonia, seizures, anxiety/depression, infections, limb pains and constipation [22, 27] . Early mortality in each subgroup was associated with a number of demographic, clinical, and instrumental-laboratory characteristics based on the interpretation of the results of calculating the significance of predictors of binary classification models by machine learning methods from the Scikit-Learn library 2 . abstract: This article presents a study on development of methods for analysis of data reflecting the process of treatment of stroke inpatients to predict clinical outcomes at the emergency care unit. The aim of this work is to develop models for the creation of validated risk scales for early intravenous stroke with minimum number of parameters with maximum prognostic accuracy and possibility to calculate the time of “expected intravenous stroke mortality”. The study of experience in the development and use of medical information systems allows us to state the insufficient ability of existing models for adequate data analysis, weak formalization and lack of system approach in the collection of diagnostic data, insufficient personalization of diagnostic data on the factors determining early intravenous stroke mortality. In our study we divided patients into 3 subgroups according to the time of death - up to 1 day, 1 to 3 days, and 4 to 10 days. Early mortality in each subgroup was associated with a number of demographic, clinical, and instrumental-laboratory characteristics based on the interpretation of the results of calculating the significance of predictors of binary classification models by machine learning methods from the Scikit-Learn library. The target classes in training were “mortality rate of 1 day”, “mortality rate of 1–3 days”, “mortality rate from 4 days”. AUC ROC of trained models reached 91% for the method of random forest. The results of interpretation of decision trees and calculation of significance of predictors of built-in methods of random forest coincide that can prove to correctness of calculations. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303676/ doi: 10.1007/978-3-030-50423-6_29 id: cord-275828-c6d6nk7x author: Mikasa, Keiichi title: JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date: 2016-07-31 words: 39672.0 sentences: 2522.0 pages: flesch: 42.0 cache: ./cache/cord-275828-c6d6nk7x.txt txt: ./txt/cord-275828-c6d6nk7x.txt summary: -SBT/ABPC, intravenous drip, 3 g/3e4 times a day -CTRX, intravenous drip, 1 g/twice a day or 2 g/once a day -CTX, intravenous drip, 1e2 g/2e3 times a day -LVFX, intravenous drip, 500 mg/once a day (2) Cases of late-onset hospital-acquired pneumonia or ventilator-associated pneumonia in which the risk of resistant bacteria is high An antimicrobial drug with anti-pseudomonal activity that targets non-glucose-fermentative gram-negative rod should be administered [50, 51, 68] -To treat polymicrobial infection, the administration of an antimicrobial drug with an activity against obligate anaerobe is not always necessary [67, 70] . -SBT/ABPC, intravenous drip, 3 g/3e4 times a day -CTRX, intravenous drip, 2 g/once a day or 1 g/twice a day -CTX, intravenous drip, 1e2 g/2e3 times a day -LVFX, intravenous drip, 500 mg/once a day (2) Late-onset hospital-acquired pneumonia or cases in which there is a risk of multi-drug-resistant bacteria In addition to the above pathogens, the involvement of non-glucose-fermentative gram negative bacteria or ESBLproducing enteric bacteria must be considered. For the treatment of immunodeficiency-/blood disease-related pneumonia in children, antimicrobial drug therapy should also be basically selected, considering causative microorganisms. abstract: nan url: https://api.elsevier.com/content/article/pii/S1341321X16000283 doi: 10.1016/j.jiac.2015.12.019 id: cord-266156-xmf4emln author: Miller, Tyler E. title: Clinical sensitivity and interpretation of PCR and serological COVID‐19 diagnostics for patients presenting to the hospital date: 2020-08-28 words: 4329.0 sentences: 221.0 pages: flesch: 45.0 cache: ./cache/cord-266156-xmf4emln.txt txt: ./txt/cord-266156-xmf4emln.txt summary: Our goal was to examine the clinical sensitivity of two most common SARS‐CoV‐2 diagnostic test modalities, polymerase chain reaction (PCR) and serology, over the disease course to provide insight into their clinical interpretation in patients presenting to the hospital. The goal of this study is to examine the clinical sensitivity and provide insights into the interpretation of the two most common SARS-CoV-2 diagnostic test modalities: polymerase chain reaction (PCR) and serology. Serologic analysis of IgM, IgA and IgG status was performed in a subset of the above SARS-CoV-2 PCR-positive patients for which we had excess material in the MGH core laboratories for clinical validation studies. To assess the sensitivity of our serology assay over time, we tested for IgM, IgG, and IgA antibodies against the RBD of SARS-CoV-2 spike protein in 157 SARS-CoV-2 PCR-positive patients using an in-house ELISA (Table 1) . abstract: The diagnosis of COVID‐19 requires integration of clinical and laboratory data. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) diagnostic assays play a central role in diagnosis and have fixed technical performance metrics. Interpretation becomes challenging because the clinical sensitivity changes as the virus clears and the immune response emerges. Our goal was to examine the clinical sensitivity of two most common SARS‐CoV‐2 diagnostic test modalities, polymerase chain reaction (PCR) and serology, over the disease course to provide insight into their clinical interpretation in patients presenting to the hospital. We conducted a single‐center, retrospective study. To derive clinical sensitivity of PCR, we identified 209 PCR‐positive SARS‐CoV‐2 patients with multiple PCR test results (624 total PCR tests) and calculated daily sensitivity from date of symptom onset or first positive test. Clinical sensitivity of PCR decreased with days post symptom onset with >90% clinical sensitivity during the first 5 days after symptom onset, 70%‐71% from Days 9 to 11, and 30% at Day 21. To calculate daily clinical sensitivity by serology, we utilized 157 PCR‐positive patients with a total of 197 specimens tested by enzyme‐linked immunosorbent assay for IgM, IgG, and IgA anti‐SARS‐CoV‐2 antibodies. In contrast to PCR, serological sensitivity increased with days post symptom onset with >50% of patients seropositive by at least one antibody isotype after Day 7, >80% after Day 12, and 100% by Day 21. Taken together, PCR and serology are complimentary modalities that require time‐dependent interpretation. Superimposition of sensitivities over time indicate that serology can function as a reliable diagnostic aid indicating recent or prior infection. url: https://www.ncbi.nlm.nih.gov/pubmed/32856766/ doi: 10.1096/fj.202001700rr id: cord-301947-b6nwaost author: Millán-Oñate, José title: Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin date: 2020-04-24 words: 3699.0 sentences: 205.0 pages: flesch: 48.0 cache: ./cache/cord-301947-b6nwaost.txt txt: ./txt/cord-301947-b6nwaost.txt summary: We report here the clinical features and therapeutic course of the first reported patient with confirmed COVID-19 pneumonia that recovered in Colombia, after the use of chloroquine and clarithromycin. It is essential to acknowledge that no good controlled data are supporting the use of any of these agents, except for a recent randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, that showed no benefit with lopinavir-ritonavir (LPV/RTV) treatment beyond standard care [13] . We present a confirmed case of COVID-19 from Buga, Valle del Cauca, Colombia, that successful recovered of SARS-CoV-2 infection after receiving chloroquine. Although that just based in one case, we cannot recommend the use of these drugs, our patient improved significantly, and his clinical manifestations ceased, including becoming negative for the SARS-CoV-2 infection, as observed in the rRT-PCR test. abstract: BACKGROUND: COVID-19 pandemics is a challenge for public health and infectious diseases clinicians, especially for the therapeutical approach that is not yet adequately defined. Amid this situation, investigational agents are being used, including chloroquine. We report here the clinical features and therapeutic course of the first reported patient with confirmed COVID-19 pneumonia that recovered in Colombia, after the use of chloroquine and clarithromycin. CASE PRESENTATION: A 34-year-old male, returning from Spain, presented with complaints of fever, and cough, and class-II obesity, being hospitalized. The respiratory viruses and bacteria tested by FilmArray(®) PCR were negative. Two days later, clarithromycin was started because the patient was suspected as community-acquired pneumonia. At the third day, the rRT-PCR confirmed the SARS-CoV-2 infection. A day later, chloroquine was started because of that. His chest computed tomography was performed and showed bilateral multifocal ground-glass opacities with consolidation, which suggested viral pneumonia as a differential diagnosis. Progressively his clinical condition improved and at day 9, patient rRT-PCR for SARS-CoV-2 became negative. The patient was discharged and isolated at home per 14 days. CONCLUSIONS: Our patient improved significantly. This and other COVID-19 cases are urgently demanding results from clinical trials that support evidence-based therapeutical approaches to this pandemic and the clinical management of patients, especially those at critical care. url: https://doi.org/10.1186/s12941-020-00358-y doi: 10.1186/s12941-020-00358-y id: cord-285096-g9y3au1a author: Mitchell, Judy A. title: Tropism and pathological findings associated with canine respiratory coronavirus (CRCoV) date: 2013-03-23 words: 7120.0 sentences: 340.0 pages: flesch: 50.0 cache: ./cache/cord-285096-g9y3au1a.txt txt: ./txt/cord-285096-g9y3au1a.txt summary: Following experimental infection in dogs, all five CRCoV isolates gave rise to clinical signs of respiratory disease consistent with that observed during natural infection. Following experimental infection in dogs, all five CRCoV isolates gave rise to clinical signs of respiratory disease consistent with that observed during natural infection. In that study we demonstrated that young dogs were susceptible to experimental infection with both CRCoV isolates, which gave rise to clinical signs of respiratory disease consistent with naturally occurring infection. Analyses specifically focused on the histopathological changes in the canine upper and lower respiratory tissues, virulence differences among CRCoV isolates derived from CIRD cases representing wide geographical locations; UK and USA [MO, NE, UT and MI] , and the demonstration of Koch''s postulates. Consistent with observations made during naturally occurring infection, dogs in this study also displayed clinical signs of mild respiratory disease following viral challenge (nasal discharge, sneezing, and coughing); whilst the control group remained healthy. abstract: Canine infectious respiratory disease (CIRD) occurs frequently in densely housed dog populations. One of the common pathogens involved is canine respiratory coronavirus (CRCoV), however little is known regarding its pathogenesis and the role it plays in the development of CIRD. The pathogenesis of five geographically unrelated canine respiratory coronavirus (CRCoV) isolates was investigated. Following experimental infection in dogs, all five CRCoV isolates gave rise to clinical signs of respiratory disease consistent with that observed during natural infection. The presence of CRCoV was associated with marked histopathological changes in the nares and trachea, with loss and damage to tracheal cilia, accompanied by inflammation. Viral shedding was readily detected from the oropharynx up to 10 days post infection, but there was little or no evidence of rectal shedding. The successful re-isolation of CRCoV from a wide range of respiratory and mucosal associated lymphoid tissues, and lung lavage fluids demonstrates a clear tropism of CRCoV for respiratory tissues and fulfils the final requirement for Koch's postulates. By study day 14 dogs had seroconverted to CRCoV and the antibodies raised were neutralising against both homologous and heterologous strains of CRCoV in vitro, thus demonstrating antigenic homogeneity among CRCoV strains from the two continents. Defining the role that CRCoV and other agents play in CIRD is a considerable, but important, challenge if the disease is to be managed, treated and prevented more successfully. Here we have successfully developed a model for studying the pathogenicity and the role of CRCoV in CIRD. url: https://doi.org/10.1016/j.vetmic.2012.11.025 doi: 10.1016/j.vetmic.2012.11.025 id: cord-274497-tqceazdp author: N. Nuñez, Luis Fabian title: Molecular Characterization and Pathogenicity of Chicken Parvovirus (ChPV) in Specific Pathogen-Free Chicks Infected Experimentally date: 2020-07-25 words: 4123.0 sentences: 192.0 pages: flesch: 47.0 cache: ./cache/cord-274497-tqceazdp.txt txt: ./txt/cord-274497-tqceazdp.txt summary: In the present work, the pathogenicity, viral tissue distribution and molecular characterization of ChPV in chicks from a strain isolated in Brazil were determined with a demonstration of Koch''s postulates according to our previous description [21] . In the present work, the pathogenicity, viral tissue distribution and molecular characterization of ChPV in chicks from a strain isolated in Brazil were determined with a demonstration of Koch''s postulates according to our previous description [21] . Experimental infections with isolated ChPV (ABU-P1) have demonstrated that the virus causes enteric diseases, resulting mainly in chickens with diarrhea, cloacal pasting, impaired growth, runting and stunting [32] . Lesions were previously described in commercial chicken flocks affected with RSS and reported by our own group [21] ; the duodenal loop presented the same features, demonstrating Koch''s postulates in relation to ChPV and experimentally infected chickens. abstract: Chicken parvovirus (ChPV) is an agent frequently associated with runting stunting syndrome (RSS). This syndrome has been reported in association with ChPV in many countries, including Brazil; however, studies characterizing the virus on a molecular level are scarce, and ChPV pathogenicity in day-old chicks remains unclear. The aim of the present work was to establish the molecular characteristics of ChPV, determine the pathogenicity of ChPV in SPF chicks and detect and quantify ChPV by qPCR in several tissues and chicks of different ages. The experimental challenge was performed at one day of age, and daily and weekly observations were performed and five birds from each experimental group (mock and infected birds) were euthanized to perform the different analysis. ChPV genome copies were detected and quantified by qPCR in gut, spleen, thymus, kidney, pancreas, proventriculus and bursa. Clinically, the infected group presented with diarrhea 24 h post-infection, which persisted until 42 days of age. The small intestine was distended, and its contents were aqueous and foamy. Enteritis and dilated crypts with cyst shapes were observed in intestinal segments. Acute pancreatitis associated with lymphocytic nodules, infiltrating lymphocytes and plasma cells between the pancreatic acinus was observed. Koch’s postulate was demonstrated and the genetic characterization of the VP1 gene showed that the Brazilian ChPV isolate belongs to the ChPV II group. url: https://www.ncbi.nlm.nih.gov/pubmed/32722416/ doi: 10.3390/pathogens9080606 id: cord-337129-6wt6wzxv author: Navas de Solis, Cristobal title: Transient diabetes mellitus in a neonatal Thoroughbred foal date: 2010-10-07 words: 3127.0 sentences: 212.0 pages: flesch: 55.0 cache: ./cache/cord-337129-6wt6wzxv.txt txt: ./txt/cord-337129-6wt6wzxv.txt summary: Objective – To describe the clinical presentation, treatment, and outcome of a neonatal foal diagnosed with transient Type 1 diabetes mellitus. During hospitalization the foal developed hyperglycemia concomitantly with low insulin concentration and an adequate response to exogenous insulin therapy supported a diagnosis of Type 1 diabetes mellitus. On follow up assessment the foal was found to be a healthy euglycemic animal with normal insulin concentration at 11 months of age. Type 1 diabetes mellitus should be considered a differential diagnosis for hyperglycemia in equine neonates and that it can be transient and managed successfully. The insulin concentration in normal foals from birth to 7 days of age is 13.5 AE 1.5 mU/mL. Low insulin concentrations accompanying hyperglycemia and an adequate response to exogenous insulin supports a diagnosis of Type 1 diabetes mellitus. The foal developed complications that resolved with appropriate care and was a healthy animal with normal glycemia and insulin concentration at 11 months of age. abstract: Objective – To describe the clinical presentation, treatment, and outcome of a neonatal foal diagnosed with transient Type 1 diabetes mellitus. Case Summary – A 3‐day‐old Thoroughbred foal presented with a 24‐hour history of diarrhea and depression. Coronavirus particles were observed in the feces via electron microscopy. During hospitalization the foal developed hyperglycemia concomitantly with low insulin concentration and an adequate response to exogenous insulin therapy supported a diagnosis of Type 1 diabetes mellitus. The foal required SC insulin for 26 days, but developed complications associated with insulin therapy that resolved with appropriate care. On follow up assessment the foal was found to be a healthy euglycemic animal with normal insulin concentration at 11 months of age. New or Unique Information Provided – To our knowledge this is the first report of Type 1 diabetes in this age group and the first report of transient neonatal diabetes mellitus in horses. Type 1 diabetes mellitus should be considered a differential diagnosis for hyperglycemia in equine neonates and that it can be transient and managed successfully. url: https://www.ncbi.nlm.nih.gov/pubmed/21166983/ doi: 10.1111/j.1476-4431.2010.00588.x id: cord-285812-l7dpv6nx author: O’TOOLE, D. title: Pathogenicity of experimental infection with ‘pneumotropic’ porcine coronavirus date: 1989-07-31 words: 3072.0 sentences: 163.0 pages: flesch: 45.0 cache: ./cache/cord-285812-l7dpv6nx.txt txt: ./txt/cord-285812-l7dpv6nx.txt summary: Virus localisation and lesions were studied in 14 one-week-old piglets following combined intranasal-oral inoculation with a British isolate of ''pneumotropic'' porcine coronavirus (pcv) and were compared with the effects of transmissible gastroenteritis virus (tgev) infection in five piglets. Virus localisation and lesions were studied in 14 oneweek-old piglets following combined intranasal-oral inoculation with a British isolate of ''pneumotropic'' porcine coronavirus (pcv) and were compared with the effects of transmissible gastroenteritis virus (TGEV) infection in five piglets. Following sterilisation of cages and isolators, a second batch of 12 piglets (Large White cross Landrace) aged seven days from two litters were inoculated with rev (five) or TGEV (five) or were uninoculated controls (two). Between two and six days after infection, acute changes were characterised by individual bronchiolar cells bulging into the lumen, ..; 00I''m Immunocytochemistry r-ev antigen was identified in the epithelial cytoplasm of small and medium bronchioles in eight of 14 piglets and its distribution was closely correlated with areas of pneumonia. abstract: Virus localisation and lesions were studied in 14 one-week-old piglets following combined intranasal-oral inoculation with a British isolate of ‘pneumotropic’ porcine coronavirus (pcv) and were compared with the effects of transmissible gastroenteritis virus (tgev) infection in five piglets. Unlike TGEV-infected piglets, all pcv-inoculated piglets remained clinically healthy. Seroconversion was detected at seven days after inoculation. Mild bronchointerstitial pneumonia involving terminal airways was consistently present at two days after infection and thereafter. Both pcv and tgev infected bronchiolar epithelium and alveolar macrophages but, unlike tgev, replication by pcv in villous enterocytes was limited and did not cause villous atrophy. url: https://www.sciencedirect.com/science/article/pii/S0034528818312268 doi: 10.1016/s0034-5288(18)31226-8 id: cord-268341-103xf3dw author: Parra, Beatriz title: Kinetics of Cytokine mRNA Expression in the Central Nervous System Following Lethal and Nonlethal Coronavirus-Induced Acute Encephalomyelitis date: 1997-07-07 words: 5778.0 sentences: 316.0 pages: flesch: 49.0 cache: ./cache/cord-268341-103xf3dw.txt txt: ./txt/cord-268341-103xf3dw.txt summary: the plaque size and pathogenesis similar to the parental During JHMV infection of the CNS there is an abrupt suckling mouse brain pool of JHMV originally described increase in mRNA encoding interleukin-1 (a and b), ILby Weiner (1973) and produces a lethal encephalomyeli-6, tumor necrosis factor (TNF)-a, and interferon (IFN)-g, tis with minimal demyelination apparent at the time of at the time of maximal decrease in virus replication and death. Similar of mice through Day 5 postinfection, consistent with the to the kinetics of IFN-g, TNF-a mRNA increased until rapid accumulation of both NK and T cells in the CNS of death of lethally infected mice. Similarly, the adoptive transfer at the time most lethally infected mice were about to succumb to infection (Day 7), there was no difference in the of virus-specific CD4 / T cells to JHMV-infected mice demonstrates that some clones protect via reducing viral peak levels of IL-10 mRNA between the two groups. abstract: Abstract The potential role(s) of cytokines in the reduction of infectious virus and persistent viral infection in the central nervous system was examined by determining the kinetics of cytokine mRNA expression following infection with the neurotropic JHM strain of mouse hepatitis virus. Mice were infected with an antibody escape variant which produces a nonlethal encephalomyelitis and compared to a clonal virus population which produces a fulminant fatal encephalomyelitis. Infection with both viruses induced the accumulation of mRNAs associated with Th1- and Th2-type cytokines, including IFN-γ, IL-4, and IL-10. Peak mRNA accumulations were coincident with the clearance of virus and there was no obvious differences between lethally and nonlethally infected mice. TNF-α mRNA was induced more rapidly in lethally infected mice compared to mice undergoing a nonfatal encephalomyelitis. Rapid transient increases in the mRNAs encoding IL-12, iNOS, IL-1α, IL-1β, and IL-6 occurred following infection. Nonlethal infections were associated with increased IL-12, IL-1β, and earlier expression of IL-6, while lethal infections were associated with increased iNOS and IL-1α mRNA. These data suggest a rapid but differential response within the central nervous system cells to infection by different JHMV variants. However, neither the accumulation nor kinetics of induction provide evidence to distinguish lethal infections from nonlethal infections leading to a persistent infection. Accumulation of both Th1 and Th2 cytokines in the central nervous system of JHMV-infected mice is consistent with the participation of both cytokines and cell immune effectors during resolution of acute viral-induced encephalomyelitis. url: https://api.elsevier.com/content/article/pii/S004268229798613X doi: 10.1006/viro.1997.8613 id: cord-300570-xes201g7 author: Patwardhan, J. title: PREDICTIONS FOR EUROPE FOR THE COVID-19 PANDEMICAFTER LOCKDOWN WAS LIFTED USING AN SIR MODEL date: 2020-10-06 words: 5297.0 sentences: 247.0 pages: flesch: 64.0 cache: ./cache/cord-300570-xes201g7.txt txt: ./txt/cord-300570-xes201g7.txt summary: The data is observed to fit the model as predicted until around 150 days after December 31, 2019, after which many countries lift their lockdowns and begin to reopen. An analysis of the residuals is provided to locate the precise date of the departure of each country from its accepted data estimates and test each data point to its predicted value using a Z-test to determine whether each observation can fit the given model. After around Day 170, the model predicts small X2 values with small standards of deviation, so observed residuals at this point mostly represent the growth of the virus itself during that time. Finally, an examination of the date of the first deaths in each country compared to the days until the model began to deviate from its expected behavior yields no relation, indicating that any failure of the observed data points to conform to the model is most likely due to the policy measures taken in each country. abstract: I analyze a simplified SIR model developed from a paper written by Gyan Bhanot and Charles de Lisi in May of 2020 to find the successes and limitations of their predictions. In particular, I study the predicted cases and deaths fitted to data from March and its potential application to data in September. The data is observed to fit the model as predicted until around 150 days after December 31, 2019, after which many countries lift their lockdowns and begin to reopen. A plateau in cases followed by an increase approximately 1.5 months after is also observed. In terms of deaths, the data fits the shape of the model, but the model mostly underestimates the death toll after around 160 days. An analysis of the residuals is provided to locate the precise date of the departure of each country from its accepted data estimates and test each data point to its predicted value using a Z-test to determine whether each observation can fit the given model. The observed behavior is matched to policy measures taken in each country to attach an explanation to these observations. I notice that an international reopening results in a sharp increase in cases, and aim to plot this new growth in cases and predict when the pandemic will end for each country. url: http://medrxiv.org/cgi/content/short/2020.10.03.20206359v1?rss=1 doi: 10.1101/2020.10.03.20206359 id: cord-007288-lzxi6q1p author: Pazin, George J. title: Leukocyte Interferon for Treating First Episodes of Genital Herpes in Women date: 1987-12-17 words: 4199.0 sentences: 226.0 pages: flesch: 52.0 cache: ./cache/cord-007288-lzxi6q1p.txt txt: ./txt/cord-007288-lzxi6q1p.txt summary: Women experiencing their first episodes of genital herpes were treated, beginning within three days of the onset of lesions, with 5 × 10(4) units of human leukocyte interferon/kg of body weight for 12 doses over 14 days (total, ∼3.6 × 10(7) units) or with placebo in equivalent volumes. We clinically and virologically assessed the effect of early treatmentwith leukocyte interferon (Cantellvariety) [13] on the initial episode of'' genital herpes.Weindirectly evaluated the effect of .interferon on latency by determining the incidence and frequency of both asymptomatic reactivations and symptomatic recurrences during an intensive one-year follow-up period. Overall, interferon treatment at rv3 x 10 6 U/day had an ameliorative effect on both shedding of virus and the time to healing of initial episodes of genital herpes, but had no significant effect on the associated pain. abstract: Women experiencing their first episodes of genital herpes were treated, beginning within three days of the onset of lesions, with 5 × 10(4) units of human leukocyte interferon/kg of body weight for 12 doses over 14 days (total, ∼3.6 × 10(7) units) or with placebo in equivalent volumes. Life-table analysis revealed quicker healing and significant reductions in the duration of shedding of virus in interferon-treated patients. Maximum daily geometric mean titers of virus and total area of unhealed lesions also decreased more quickly. No statistically significant difference in resolution of pain was seen between the two groups. Interferon had no effect on onset or frequency of subsequent recurrences recorded over one year of follow-up. Moderate, transient neutropenia occurred in 13 of 34 interferon-treated patients. A therapeutic effect of human leukocyte interferon on initial genital herpes was documented, but the clinical usefulness of interferon treatment of genital herpes is limited at this time. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110197/ doi: 10.1093/infdis/156.6.891 id: cord-278224-sq7tokbx author: Protopopova, Alexandra title: Behavioral predictors of subsequent respiratory illness signs in dogs admitted to an animal shelter date: 2019-10-23 words: 7588.0 sentences: 391.0 pages: flesch: 48.0 cache: ./cache/cord-278224-sq7tokbx.txt txt: ./txt/cord-278224-sq7tokbx.txt summary: Therefore, the aim of the study was to explore whether behavior at intake can predict subsequent occurrence and progression of upper respiratory disease in dogs at animal shelters. At the time of the study, the animal shelter had poor disease management practices, including poor sanitation, poor medical care, no vaccination at-intake, overcrowding, and continuous rotation of dogs in the kennels. This short observation period was previously used to detect behavioral differences across kenneled dogs in the animal shelter environment [28, 29] . To evaluate whether the latent temperament variables were associated with health, we proposed a basic structural model in which Curiosity, Sociability, Anxiety, Activity, and Time in the Shelter independently predicted Illness (Fig 1) . To evaluate whether Activity, Sociability, Anxiety, Curiosity, and Time in the shelter were related to the illness score, we conducted a basic PLS Path regression model in which our 5 latent variables were tested for association with illness. abstract: Individual variability is evident in behavior and physiology of animals. Determining whether behavior at intake may predict subsequent illness in the animal shelter may influence the management of dogs housed at animal shelters and reduce overall disease. While normally associated with mild disease and low mortality rates, respiratory disease nevertheless poses significant challenges to the management of dogs in the stressful environment of animal shelters due to its highly infectious nature. Therefore, the aim of the study was to explore whether behavior at intake can predict subsequent occurrence and progression of upper respiratory disease in dogs at animal shelters. In a correlational study, 84 dogs were assessed throughout their stay at a city animal shelter. The dogs were subjected to a behavioral assessment, 1 min in-kennel behavioral observations across two observation periods, and the collection of urinary cortisol:creatinine (C:C) ratio. The occurrence and progression of upper respiratory disease was monitored through repeated clinical exams (rectal temperature and the occurrence of nasal and ocular discharge, and presence of coughing and sneezing). A basic PLS Path regression model revealed that time in the shelter (estimate = .53, p < .001), and sociability (estimate = .24, p < .001) and curiosity scores (estimate = .09, p = .026) were associated with increased illness. Activity and anxiety scores, however, were not associated with illness. Urinary C:C, taken on the first full day, did not predict subsequent illness when accounting for time. Limitations included attrition of dogs, a small percentage receiving vaccinations, and continuous and non-systematic rotation of dogs in the kennels. Understanding if behavior can predict subsequent illness may improve shelter management practices, and in turn, result in improved live-release outcomes. url: https://doi.org/10.1371/journal.pone.0224252 doi: 10.1371/journal.pone.0224252 id: cord-266183-uzuda3ir author: Renieris, Georgios title: Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Corona virus date: 2020-05-18 words: 2204.0 sentences: 143.0 pages: flesch: 49.0 cache: ./cache/cord-266183-uzuda3ir.txt txt: ./txt/cord-266183-uzuda3ir.txt summary: In light of these observations suggesting a pivotal role of H2S in the pathogenesis of Covid-19, we studied the serum levels of H2S and its association with final outcome in a cohort of patients with Covid-19 pneumonia. Due to the described anti-inflammatory properties, we hypothesize that elevated levels of H2S in serum are associated with a favourable outcome of Covid-19 pneumonia. Pneumonia Severity Index (PSI) (9); (iii) absolute blood cell counts and biochemistry on admission and follow-up; and 28-day survival. Following ROC curve analysis, it was found that serum levels of H2S on day 1 lower than 150.44μΜ had the best trade-off for sensitivity and specificity for death (Figure 3Aand B ). Forward stepwise Cox regression analysis showed that serum H2S on day 1 above 150.44μM is an independent protective factor for unfavourable outcome of COVID-19 even in the presence of severity scores (Table 1) . abstract: BACKGROUND: The pneumonia of COVID-19 illness has often a subtle initial presentation making mandatory the use of biomarkers for evaluation of severity and prediction of final patient disposition. We evaluated the use of hydrogen sulfide (H2S) for the outcome of COVID-19 pneumonia. MATERIALS & METHODS: We studied 74 patients with COVID-19. Clinical data were collected, and survival predictors were calculated. Blood was collected within 24 hours after admission (day 1) and on day 7. H2S was measured in sera by monobromobimane derivation (MBB) followed by high performance liquid chromatography and correlated to other markers like procalcitonin (PCT) and C- reactive protein (CRP). Tumor necrosis factor alpha (TNFα) and interleukin (IL)-6 were also measured in serum. RESULTS: Survivors had significantly higher H2S levels on day 1 and 7 after admission. A cut-off point of 150.44 μM could discriminate survivors from non-survivors with 80% sensitivity, 73.4% specificity and negative predictive value 95.9%. Mortality after 28 days was 32% with admission levels lower or equal to 150.44 μΜ and 4.1% with levels above 150.44 μΜ (p: 0.0008). Mortality was significantly greater among patients with a decrease of H2S levels from day 1 to day 7 greater or equal to 36% (p: 0.0005). Serum H2S on day 1 was negatively correlated with IL- 6 and CRP and positively correlated with the absolute lymphocyte count in peripheral blood. CONCLUSION: It is concluded that H2S is a potential marker for severity and final outcome of pneumonia by the SARS-CoV-2 coronavirus. Its correlation with IL- 6 suggests anti-inflammatory properties. url: https://doi.org/10.1097/shk.0000000000001562 doi: 10.1097/shk.0000000000001562 id: cord-271180-cnrs0zpg author: Rizvi, Saniya title: Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? A case report. date: 2020-09-18 words: 3896.0 sentences: 220.0 pages: flesch: 49.0 cache: ./cache/cord-271180-cnrs0zpg.txt txt: ./txt/cord-271180-cnrs0zpg.txt summary: CytosorbentsⓇ cytokine filter is a potential treatment methodology aimed at reducing the cytokine storm, thus serving as a bridge for therapy in the acutely ill patients infected with COVID-19. The following case report demonstrates the utility in a critically ill patient who survived the cytokine storm after receiving the cytokine filter via continuous renal replacement therapy bridging him to further definitive therapy. The following is a case report on a patient encounter and management course through the course of illness in which the Cytosorbents Ⓡ filter was used for his presentation of COVID-19 with severe ARDS, worsening renal dysfunction and evidence of evolving cytokine storm. Chest x-ray hospital day 16, 5 days after the initiation of cytokine filter when the patient developed worsening hypoxia and increased oxygen requirements as indicated in Table 2 below. abstract: COVID-19 is a pandemic that has affected not only the United States, but the entire world. The impact it has had has overwhelmed the entire healthcare system, from the unknown carrier status, poor testing capabilities to hospitals running out of ventilators for severely ill patients. There has been a variety of potential treatment modalities for the various forms of illness ranging from asymptomatic carriers to the ventilated ICU patients. These include anti-inflammatory medications, antibiotics, immune-modulators, convalescent plasma, and others. The cytokine storm that inflicts some patients can be devastating to the vital organs of the human body in the form of acute respiratory distress syndrome (ARDS), renal failure, coagulopathy, and death. CytosorbentsⓇ cytokine filter is a potential treatment methodology aimed at reducing the cytokine storm, thus serving as a bridge for therapy in the acutely ill patients infected with COVID-19. The following case report demonstrates the utility in a critically ill patient who survived the cytokine storm after receiving the cytokine filter via continuous renal replacement therapy bridging him to further definitive therapy. url: https://api.elsevier.com/content/article/pii/S0147956320303708 doi: 10.1016/j.hrtlng.2020.09.007 id: cord-319933-yp9ofhi8 author: Ruiz, Sara I. title: Chapter 38 Animal Models of Human Viral Diseases date: 2013-12-31 words: 28834.0 sentences: 1797.0 pages: flesch: 46.0 cache: ./cache/cord-319933-yp9ofhi8.txt txt: ./txt/cord-319933-yp9ofhi8.txt summary: An experimental study with cell culture-adapted hepatitis Avirus in guinea pigs challenged by oral or intraperitoneal routes did not result in clinical disease, increase in liver enzymes, or seroconversion. 32 NHPs including marmosets, cotton-top tamarins, and rhesus macaques infected with Norwalk virus can be monitored for the extent of viral shedding; however, no clinical disease is observed in these models. 66, 67 Intracerebral and intranasal routes of infection resulted in a fatal disease that was highly dependent on dose, while intradermal and subcutaneous inoculations caused only 50% fatality in mice regardless of the amount of virus. A mouse-adapted (MA) strain of Dengue virus 2 introduced into AG129 mice developed vascular leak syndrome similar to the severe disease seen in humans. [138] [139] [140] [141] [142] [143] [144] Inoculation of WNV into NHPs intracerebrally resulted in the development of either encephalitis, febrile disease, or an asymptomatic infection, depending on the virus strain and dose. abstract: Abstract As the threat of exposure to emerging and reemerging viruses within a naive population increases, it is vital that the basic mechanisms of pathogenesis and immune response be thoroughly investigated. By using animal models in this endeavor, the response to viruses can be studied in a more natural context to identify novel drug targets, and assess the efficacy and safety of new products. This is especially true in the advent of the Food and Drug Administration's animal rule. Although no one animal model is able to recapitulate all the aspects of human disease, understanding the current limitations allows for a more targeted experimental design. Important facets to be considered before an animal study are the route of challenge, species of animals, biomarkers of disease, and a humane endpoint. This chapter covers the current animal models for medically important human viruses, and demonstrates where the gaps in knowledge exist. url: https://api.elsevier.com/content/article/pii/B9780124158948000385 doi: 10.1016/b978-0-12-415894-8.00038-5 id: cord-018239-n7axd9bq author: Rusoke-Dierich, Olaf title: Travel Medicine date: 2018-03-13 words: 8527.0 sentences: 660.0 pages: flesch: 60.0 cache: ./cache/cord-018239-n7axd9bq.txt txt: ./txt/cord-018239-n7axd9bq.txt summary: The following topics should be included in the travel advice consultation: 5 Vaccinations (general and country specific) 5 Country-specific diseases 5 Malaria prophylaxis 5 Mosquito prophylaxis (wearing bright long-sleeved clothes, avoiding perfume, staying in air-conditioned rooms, using a mosquito net, using insect repellents, staying inside at dawn and dusk) 5 Food consumption and drinking overseas (no consumption of ice cubes, uncooked meals, salads and food, which is exposed to flies, limited alcohol consumption) 5 UV protection (using sun cream, avoiding sun exposure between 11.00 and 15.00 o'' clock, remaining in shaded areas, wearing a hat and covering skin) 5 Fitness assessment for travelling, flying and diving 5 Challenges of different climates and their effects on the personal health (dehydration, hyperthermia) 5 Medications 5 Thrombosis counselling 5 Counselling on symptoms on return, which require review (fever, skin changes, abnormal bleeding, lymphadenopathy, diarrhoea) 5 Sexual transmitted diseases 5 Contraception 5 Rabies abstract: Before travelling to other countries, thorough travel advice should be provided. Not only information about diseases of specific countries but also general advice for travelling should be given on this consultation. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123067/ doi: 10.1007/978-3-319-73836-9_32 id: cord-000705-w52dc97h author: Ríos, Fernando G title: Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic date: 2011-08-17 words: 4859.0 sentences: 301.0 pages: flesch: 48.0 cache: ./cache/cord-000705-w52dc97h.txt txt: ./txt/cord-000705-w52dc97h.txt summary: METHOD: This was a multicenter, prospective inception cohort study including adult patients with acute respiratory failure requiring mechanical ventilation (MV) admitted to 20 ICUs in Argentina between June and September of 2009 during the influenza A (H1N1) pandemic. Although a mild form of the disease was prevalent, it soon became evident that the 2009 influenza A (H1N1) virus could also provoke severe, acute respiratory failure requiring admission to the intensive care unit (ICU) for mechanical ventilation [16] , which was reflected in the severe pathological injury found at autopsy [17] . This was a multicenter, inception cohort study that included patients aged > 15 years admitted to the ICU with a previous history of influenza-like illness, evolving to acute respiratory failure that required mechanical ventilation during the 2009 winter in the Southern Hemisphere. We report on a large, prospective cohort of 2009 influenza A (H1N1) patients that were mechanically ventilated for acute respiratory failure due to diffuse pneumonitis during the pandemic in Argentina. abstract: INTRODUCTION: Most cases of the 2009 influenza A (H1N1) infection are self-limited, but occasionally the disease evolves to a severe condition needing hospitalization. Here we describe the evolution of the respiratory compromise, ventilatory management and laboratory variables of patients with diffuse viral pneumonitis caused by pandemic 2009 influenza A (H1N1) admitted to the ICU. METHOD: This was a multicenter, prospective inception cohort study including adult patients with acute respiratory failure requiring mechanical ventilation (MV) admitted to 20 ICUs in Argentina between June and September of 2009 during the influenza A (H1N1) pandemic. In a standard case-report form, we collected epidemiological characteristics, results of real-time reverse-transcriptase--polymerase-chain-reaction viral diagnostic tests, oxygenation variables, acid-base status, respiratory mechanics, ventilation management and laboratory tests. Variables were recorded on ICU admission and at days 3, 7 and 10. RESULTS: During the study period 178 patients with diffuse viral pneumonitis requiring MV were admitted. They were 44 ± 15 years of age, with Acute Physiology And Chronic Health Evaluation II (APACHE II) scores of 18 ± 7, and most frequent comorbidities were obesity (26%), previous respiratory disease (24%) and immunosuppression (16%). Non-invasive ventilation (NIV) was applied in 49 (28%) patients on admission, but 94% were later intubated. Acute respiratory distress syndrome (ARDS) was present throughout the entire ICU stay in the whole group (mean PaO(2)/FIO(2 )170 ± 25). Tidal-volumes used were 7.8 to 8.1 ml/kg (ideal body weight), plateau pressures always remained < 30 cmH(2)O, without differences between survivors and non-survivors; and mean positive end-expiratory pressure (PEEP) levels used were between 8 to 12 cm H(2)O. Rescue therapies, like recruitment maneuvers (8 to 35%), prone positioning (12 to 24%) and tracheal gas insufflation (3%) were frequently applied. At all time points, pH, platelet count, lactate dehydrogenase assay (LDH) and Sequential Organ Failure Assessment (SOFA) differed significantly between survivors and non-survivors. Lack of recovery of platelet count and persistence of leukocytosis were characteristic of non-survivors. Mortality was high (46%); and length of MV was 10 (6 to 17) days. CONCLUSIONS: These patients had severe, hypoxemic respiratory failure compatible with ARDS that persisted over time, frequently requiring rescue therapies to support oxygenation. NIV use is not warranted, given its high failure rate. Death and evolution to prolonged mechanical ventilation were common outcomes. Persistence of thrombocytopenia, acidosis and leukocytosis, and high LDH levels found in non-survivors during the course of the disease might be novel prognostic findings. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387643/ doi: 10.1186/cc10369 id: cord-274860-7ec2jcoq author: Salazar, Eric title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG date: 2020-11-04 words: 4738.0 sentences: 234.0 pages: flesch: 47.0 cache: ./cache/cord-274860-7ec2jcoq.txt txt: ./txt/cord-274860-7ec2jcoq.txt summary: title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG We recently reported results from interim analysis of a propensity-score matched study suggesting that early treatment of COVID-19 patients with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG significantly decreases mortality. In the aggregate, the analysis confirms and extends our previous preliminary finding that transfusion of COVID-19 patients soon after hospitalization with high titer anti-spike protein RBD IgG present in convalescent plasma significantly reduces mortality. In our previous study, interim analysis revealed that, relative to matched controls, patients transfused with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG within 72 hrs of hospital admission had significantly reduced mortality at 28 days post-transfusion. The data confirm our previous findings that transfusion of patients soon after hospital admission with high titer anti-spike protein RBD IgG present in convalescent plasma significantly decreases mortality. abstract: Coronavirus disease 2019 (COVID-19) convalescent plasma has emerged as a promising therapy and has been granted emergency use authorization by the U.S. Food and Drug Administration (FDA) for hospitalized COVID-19 patients. We recently reported results from interim analysis of a propensity-score matched study suggesting that early treatment of COVID-19 patients with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG significantly decreases mortality. We here present results from 60-day follow up of our cohort of 351 transfused hospitalized patients. Prospective determination of ELISA anti-RBD IgG titer facilitated selection and transfusion of the highest titer units available. Retrospective analysis by the Ortho VITROS IgG assay revealed a median signal/cutoff (S/C) ratio of 24.0 for transfused units, a value far exceeding the recently FDA-required cutoff of 12.0 for designation of high titer convalescent plasma. With respect to altering mortality, our analysis identified an optimal window of 44 hours post-hospitalization for transfusing COVID-19 patients with high titer convalescent plasma. In the aggregate, the analysis confirms and extends our previous preliminary finding that transfusion of COVID-19 patients soon after hospitalization with high titer anti-spike protein RBD IgG present in convalescent plasma significantly reduces mortality. url: https://www.ncbi.nlm.nih.gov/pubmed/33157066/ doi: 10.1016/j.ajpath.2020.10.008 id: cord-271298-7vk3wgw1 author: Sato, Tomoi title: Feeding behavior during sialodacryoadenitis viral infection in rats date: 2001-04-30 words: 3278.0 sentences: 169.0 pages: flesch: 49.0 cache: ./cache/cord-271298-7vk3wgw1.txt txt: ./txt/cord-271298-7vk3wgw1.txt summary: This pattern of decreased food intake is similar to that occurring during indomethacin-induced ulcerative ileitis, where we previously measured an increase in plasma tumor-necrosis factor (TNF)-α. The differences in the decrease in the feeding pattern between the SDA viral and a bacterial infection suggest that factors other than TNF-α alone play a significant role in the mechanism of anorexia during a viral infection. An Automated Computerized Rat Eater Meter (ACREM; [7] ), which measures individual meal size and meal number as well as food intake for prolonged periods, provides us with the ability to characterize the biological manifestations associated with feeding behavior including anorexia. Since these cytokines act on the hypothalamus to modulate food intake and feeding behavior, they might have a direct or an indirect influence on the LHA to decrease meal size and on the VMN to inhibit a compensatory increase in meal number during the SDA virus infection. abstract: Sialodacryoadenitis (SDA) is a highly contagious common viral infection in rats, akin to mumps in humans. Anorexia occurs during such viral infection. But the pattern of the decrease in food intake (a decrease in either meal size and meal number or both) during spontaneous viral infection has not been previously characterized. We observed the onset of anorexia and an abnormal feeding pattern during an opportunistic SDA viral infection in our rat colony. We thus studied seven male rats. Before the viral infection there was a positive association between food intake and meal number (P<.05). After infection food intake decreased by 68%. This occurred via a significant decrease in meal size (by 69%) (P<.05); and a nonsignificant decrease in meal number (P=.71). This pattern of decreased food intake is similar to that occurring during indomethacin-induced ulcerative ileitis, where we previously measured an increase in plasma tumor-necrosis factor (TNF)-α. Anorexia in response to bacterial lipopolysaccharide administration, which is also linked to plasma TNF-α, is however, caused only via a decrease in meal number. The differences in the decrease in the feeding pattern between the SDA viral and a bacterial infection suggest that factors other than TNF-α alone play a significant role in the mechanism of anorexia during a viral infection. url: https://www.ncbi.nlm.nih.gov/pubmed/11337004/ doi: 10.1016/s0031-9384(01)00420-6 id: cord-032240-xswtx940 author: Sauer, François title: Pericardial effusion in patients with COVID-19: case series date: 2020-09-09 words: 2235.0 sentences: 167.0 pages: flesch: 51.0 cache: ./cache/cord-032240-xswtx940.txt txt: ./txt/cord-032240-xswtx940.txt summary: Case 1 was a COVID-19 cardiac tamponade without myocarditis, confirmed by a positive chest computed tomography (CT) scan. Case 3 was a cardiac tamponade due to COVID-19 pericarditis, with a positive polymerase chain reaction on pericardial fluid. Since the outbreak of clusters of viral pneumonia due to the novel coronavirus (severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2) in Wuhan, China in December 2019, 1 coronavirus disease 2019 (COVID-19) has spread worldwide infecting more than 5.4 million people and causing more than 349 095 deaths as of 27 May 2020. • Three cases of pericardial effusions (PEs) comprising two tamponades occurred in a single cardiology centre, suggesting a higher cardiac risk than expected during the coronavirus disease 2019 (COVID-19) pandemic. [3] [4] [5] [6] [7] We hereby report a case series of three patients with cardiac and pericardial manifestations of COVID-19 at our institution. Acute myopericarditis with pericardial effusion and cardiac tamponade in a patient with COVID-19 abstract: BACKGROUND: SARS-coronavirus-2 [coronavirus disease 2019 (COVID-19)] infection is a public health issue affecting millions of people. It started in Wuhan in China in December 2019 spreading rapidly worldwide. CASE SUMMARY: Three patients aged 51–84 developed a pericarditis related to COVID-19, associated for two of them with a myocarditis. Case 1 was a COVID-19 cardiac tamponade without myocarditis, confirmed by a positive chest computed tomography (CT) scan. Case 2 showed a COVID-19 myopericarditis, confirmed by a positive chest CT scan and a SARS-coronavirus-2 positive swab. Case 3 was a cardiac tamponade due to COVID-19 pericarditis, with a positive polymerase chain reaction on pericardial fluid. They were all treated by colchicine and their condition improved rapidly. DISCUSSION: Presumably rare, we reported three cases of pericardial effusions (PEs) occurring in a single cardiology centre. There is a higher incidence of COVID-19-related cardiac diseases such as pericarditis that can manifest as a minimal PE to a cardiac tamponade, which should result in a higher awareness of cardiologists. A systematic measure of the high-sensitivity troponin kinetic in patients affected by COVID-19 could be interesting in order to screen for potential myocarditis. Any unexplained haemodynamic failure or increased cardiac biomarkers should make the medical team search for myopericarditis by a transthoracic echocardiography. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499573/ doi: 10.1093/ehjcr/ytaa287 id: cord-030957-45tc5ksf author: Schaap, Andrew title: The politics of precarity date: 2020-08-28 words: 14972.0 sentences: 570.0 pages: flesch: 45.0 cache: ./cache/cord-030957-45tc5ksf.txt txt: ./txt/cord-030957-45tc5ksf.txt summary: In the final chapters, Apostolidis explores how worker centres might also function synecdochally insofar as the purpose of association is construed not only instrumentally, as protection against the risks associated with precarity, but in terms of their constitutive potential to sustain convivial networks of political possibility for more mutually supportive, creative and pluralistic forms of solidarity than those afforded by traditional unionised spaces. Paul Apostolidis'' book The Fight for Time encapsulates a very similar kind of intellectual-political project as it also seeks to capture the self-understandings of migrant day labourers in their everyday struggles, to reflect on how they resonate with contemporary critical theoretical concepts and to learn how, taken together, these empirical and conceptual insights may lead us to a renewed vision of what a left politics might look like for our age. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453180/ doi: 10.1057/s41296-020-00435-z id: cord-224211-6lsvjfqb author: Schaback, Robert title: Modelling Recovered Cases and Death Probabilities for the COVID-19 Outbreak date: 2020-03-26 words: 814.0 sentences: 56.0 pages: flesch: 70.0 cache: ./cache/cord-224211-6lsvjfqb.txt txt: ./txt/cord-224211-6lsvjfqb.txt summary: title: Modelling Recovered Cases and Death Probabilities for the COVID-19 Outbreak From March 23rd, the data for the recovered cases of COVID-19 are missing from the standard repository maintained by the Johns Hopkins University in collaboration with the WHO. But since data concerning recovered patients are extremely important for modelling the COVID-19 outbreak, a method for estimating the missing data is provided and tested. As a byproduct, it produces estimates for the probabilities to die $k$ days after confirmation, or to survive after $d$ days. The COVID-19 repository [1] at Johns Hopkins University provides cumulative data on • Confirmed infected persons (C) and Authorities only report confirmed cases and deaths, but they say [2] that a person with mild or no symptoms is considered to be recovered after 14 days. This is automatically cumulative and maintains the integrity of person counts between the Confirmed, Deaths, and Recovered. abstract: From March 23rd, the data for the recovered cases of COVID-19 are missing from the standard repository maintained by the Johns Hopkins University in collaboration with the WHO. But since data concerning recovered patients are extremely important for modelling the COVID-19 outbreak, a method for estimating the missing data is provided and tested. As a byproduct, it produces estimates for the probabilities to die $k$ days after confirmation, or to survive after $d$ days. url: https://arxiv.org/pdf/2003.12068v1.pdf doi: nan id: cord-335490-p63qlcnx author: Schenk, Thomas title: Disseminated Bocavirus Infection after Stem Cell Transplant date: 2007-09-17 words: 1928.0 sentences: 103.0 pages: flesch: 46.0 cache: ./cache/cord-335490-p63qlcnx.txt txt: ./txt/cord-335490-p63qlcnx.txt summary: To the Editor: Human bocavirus (HBoV) (1) is increasingly recognized as a cause of respiratory infections worldwide. Retrospectively, the same NPA sample was reanalyzed for HBoV DNA by real-time PCR (7) and showed a viral load of 4.6 × 10 7 copies/mL (online Appendix Figure) ; specifi city was confi rmed by sequencing. Diarrheic stool samples obtained on day 21 and, after resolution of respiratory symptoms, on day 75 showed substantial HBoV DNA (2.5 × 10 6 and 6.0 × 10 5 copies/mg, respectively; online Appendix Figure) . Drug-induced PRCA is a rare blood disorder in adults and has already been reported in isoniazid-treated patients (3) (4) (5) . This hypothesis is supported by previously reported cases in which PRCA relapses occurred when treatment with isoniazid was resumed (3, 5) . Detection of human bocavirus in Japanese children with lower respiratory tract infections Human bocavirus DNA detected by quantitative real-time PCR in two children hospitalized for lower respiratory tract infection abstract: nan url: https://doi.org/10.3201/eid1309.070318 doi: 10.3201/eid1309.070318 id: cord-006344-de4dhv4b author: Seitsonen, E. title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection date: 2006-03-21 words: 2771.0 sentences: 174.0 pages: flesch: 48.0 cache: ./cache/cord-006344-de4dhv4b.txt txt: ./txt/cord-006344-de4dhv4b.txt summary: title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection Reported here are two cases of hantavirus pulmonary syndrome caused by Puumala virus infection, which rapidly resolved after initiation of corticosteroid treatment combined with continuous veno-venous hemodiafiltration. We describe two cases of PUU-associated HPS, in which administration of intravenous corticosteroids combined with continuous veno-venous hemodiafiltration (CVVHDF) was followed by rapid clinical improvement. On day 5 POS the lung infiltrates had increased considerably (Fig. 3a,b) , and the patient required continuous ventilation with a positive airway pressure mask. We describe two cases of PUU-infected patients who presented with both renal and respiratory failure requiring renal replacement therapy and mechanical ventilation. High levels of cytokineproducing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome High levels of viremia in patients with the Hantavirus pulmonary syndrome abstract: Reported here are two cases of hantavirus pulmonary syndrome caused by Puumala virus infection, which rapidly resolved after initiation of corticosteroid treatment combined with continuous veno-venous hemodiafiltration. These cases emphasize the role of the inflammatory response in the pathogenesis of hantavirus pulmonary syndrome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101642/ doi: 10.1007/s10096-006-0117-z id: cord-029112-u507i0t0 author: Smith, Keisha title: A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date: 2020-07-13 words: 20880.0 sentences: 1243.0 pages: flesch: 46.0 cache: ./cache/cord-029112-u507i0t0.txt txt: ./txt/cord-029112-u507i0t0.txt summary: Study ALXN1210-COV-305 is a multicenter Phase 3, open-label, randomized, controlled study designed to evaluate the safety and efficacy of intravenous (IV) ravulizumab + best supportive care (BSC), compared with BSC alone in patients with a confirmed diagnosis of SARS-CoV-2 infection, and a clinical presentation consistent with COVID-19 severe pneumonia, acute lung injury, or ARDS. abstract: OBJECTIVES: Primary Objective • To evaluate the effect of ravulizumab, a long-acting complement (C5) inhibitor plus best supportive care (BSC) compared with BSC alone on the survival of patients with COVID-19. Secondary Objectives • Number of days free of mechanical ventilation at Day 29 • Duration of intensive care unit stay at Day 29 • Change from baseline in Sequential Organ Failure Assessment (SOFA) score at Day 29 • Change from baseline in peripheral capillary oxygen saturation/ fraction of inspired oxygen (SpO2 /FiO2) at Day 29 • Duration of hospitalization at Day 29 • Survival (based on all-cause mortality) at Day 60 and Day 90 Safety • Incidence of treatment-emergent adverse events and treatment-emergent serious adverse events. PK/PD/Immunogenicity • Change in serum ravulizumab concentrations over time • Change in serum free and total C5 concentrations over time • Incidence and titer of anti-ALXN1210 antibodies Biomarkers • Change in absolute level of soluble biomarkers in blood associated with complement activation, inflammatory processes, and hypercoagulable states over time Exploratory • Incidence of progression to renal failure requiring dialysis at Day 29 • Time to clinical improvement (based on a modified 6-point ordinal scale) over 29 days • SF-12 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores at Day 29 (or discharge), Day 60, and Day 90 • EuroQol 5-dimension 5-level (EQ-5D-5L) scores at Day 29 (or discharge), Day 60, and Day 90 TRIAL DESIGN: This is a multicenter Phase 3, open-label, randomized, controlled, study. The study is being conducted in acute care hospital settings in the United States, United Kingdom, Spain, France, Germany, and Japan. PARTICIPANTS: Male or female patients at least 18 years of age, weighing ≥ 40 kg, admitted to a designated hospital facility for treatment will be screened for eligibility in this study. Key Inclusion criteria • Confirmed diagnosis of SARS-CoV-2 infection (eg, via polymerase chain reaction [PCR] and/or antibody test) presenting as severe COVID-19 requiring hospitalization • Severe pneumonia, acute lung injury, or ARDS confirmed by computed tomography (CT) or X-ray at Screening or within the 3 days prior to Screening, as part of the patient’s routine clinical care • Respiratory distress requiring mechanical ventilation, which can be either invasive (requiring endotracheal intubation) or non-invasive (with continuous positive airway pressure [CPAP] or bilevel positive airway pressure [BiPAP]) Key Exclusion criteria • Patient is not expected to survive for more than 24 hours • Patient is on invasive mechanical ventilation with intubation for more than 48 hours prior to Screening • Severe pre-existing cardiac disease (ie, NYHA Class 3 or Class 4, acute coronary syndrome, or persistent ventricular tachyarrhythmias) • Patient has an unresolved Neisseria meningitidis infection Excluded medications and therapies • Current treatment with a complement inhibitor • Intravenous immunoglobulin (IVIg) within 4 weeks prior to randomization on Day 1 Excluded prior/concurrent clinical study experience • Treatment with investigational therapy in a clinical study within 30 days before randomization, or within 5 half-lives of that investigational therapy, whichever is greater • Exceptions a. Investigational therapies will be allowed if received as part of best supportive care through an expanded access protocol or emergency approval for the treatment of COVID-19. b. Investigational antiviral therapies (such as remdesivir) will be allowed even if received as part of a clinical study. INTERVENTION AND COMPARATOR: The study consists of a Screening Period of up to 3 days, a Primary Evaluation Period of 4 weeks, a final assessment at Day 29, and a Follow-up Period of 8 weeks. For patients randomized to ravulizumab plus BSC, a weight-based dose of ravulizumab (≥40 to < 60 kg/2400 mg, 60 to < 100 kg/2700 mg, ≥ 100 kg/3000 mg) will be administered on Day 1. On Day 5 and Day 10, additional doses of 600 mg (≥40 to <60 kg) or 900 mg (>60 kg) ravulizumab will be administered and on Day 15 patients will receive 900 mg ravulizumab. There is no active or placebo comparator in this open-label clinical trial. The total duration of each patient’s participation is anticipated to be approximately 3 months. MAIN OUTCOMES: The primary efficacy outcome of this study is survival (based on all-cause mortality) at Day 29. RANDOMISATION: Patients will be randomized in a 2:1 ratio (ravulizumab plus BSC:BSC alone). Randomization will be stratified by intubated or not intubated on Day 1. Computer-generated randomization lists will be prepared by a third party under the direction of the sponsor. Investigators, or designees, will enrol patients and then obtain randomization codes using an interactive voice/web response system. The block size will be kept concealed so that investigators cannot select patients for a particular treatment assignment. Blinding (masking): This is an open-label study. Numbers to be randomised (sample size): Approximately 270 patients will be randomly assigned in a 2:1 ratio to ravulizumab plus BSC (n=180) or BSC alone (n=90). TRIAL STATUS: Protocol Number: ALXN1210-COV-305 Original Protocol: 09 Apr 2020 Protocol Amendment 1 (Global): 13 Apr 2020 Protocol Amendment 2 (Global): 17 Apr 2020 Protocol Amendment 3 (Global): 09 Jun 2020 Recruitment is currently ongoing. Recruitment was initiated on 11 May 2020. We expect recruitment to be completed by 30 Nov 2020. TRIAL REGISTRATION: Clinicaltrials.gov: Protocol Registry Number: NCT04369469; First posted; 30 Apr 2020 EU Clinical Trials Register: EudraCT Number: https://www.clinicaltrialsregister.eu/ctr-search/search?query=ALXN1210-COV-305, Start date: 07 May 2020 FULL PROTOCOL: The full redacted protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355517/ doi: 10.1186/s13063-020-04548-z id: cord-014464-m5n250r2 author: Sole-Violan, J title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 words: 98961.0 sentences: 5553.0 pages: flesch: 54.0 cache: ./cache/cord-014464-m5n250r2.txt txt: ./txt/cord-014464-m5n250r2.txt summary: Results In preliminary analysis of categorical data, a signifi cantly (Fisher exact test) greater proportion of patients with compared with without the following fi ndings did not survive; history of alcohol use (P = 0.05); the presence of lethargy (P = 0.01), confusion (P = 0.03), nausea (P = 0.04), abdominal pain (P = 0.02), or the need for vasopressors (P = 0.002), oxygen, mechanical ventilation, or steroids (all P = 0.004) at presentation; and excessive bleeding at surgery (P = 0.01). Methods To prospectively re-evaluate the normal range and to analyze the potential impact of biometric data on ICG-PDR, we measured ICG-PDR (i.v. injection of 0.25 mg/kg ICG; LiMON, Pulsion, Munich, Introduction Mixed venous oxygen saturation (SVO 2 ) represents a well-recognized parameter of oxygen delivery (DO 2 )-consumption (VO 2 ) mismatch and its use has been advocated in critically ill patients in order to guide hemodynamic resuscitation [1] and oxygen delivery optimization. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642469/ doi: 10.1186/cc11953 id: cord-303878-v2n9jeeb author: Stiles, Jonathan title: Working at home and elsewhere: daily work location, telework, and travel among United States knowledge workers date: 2020-09-05 words: 7665.0 sentences: 324.0 pages: flesch: 50.0 cache: ./cache/cord-303878-v2n9jeeb.txt txt: ./txt/cord-303878-v2n9jeeb.txt summary: (2017) used Canadian time use data to explore the relationship of working from different locations with travel, finding that some patterns of working from home were associated with less overall travel, a decreased likelihood of traveling at peak travel times, and an increased likelihood of using a non-motorized form of transport. The third section presents the results from the peak hour travel participation multinomial logistic regression models, and the final section augments this with a survival analysis of initial departure times to shed light on a mechanism of morning peak hour avoidance related to homebased work. When we combine homeworking with other non-workplace locations, such as someone who works at home in the morning and goes to a café to work later in the day, the higher likelihood of avoidance of at least some peak hour work travel remains. abstract: The mediation of work practices by information and communication technologies enables knowledge workers to telework from remote non-office locations such as their homes, or to work nomadically from multiple locations in a day. This paper uses data from the American Time Use Survey to explore the relationship between daily work locations and travel in the United States from 2003 to 2017. Outcome variables include travel duration and travel during peak periods. Home is by far the most common non-office work location, but working from other people’s homes, cafés/libraries, vehicles, and combinations of multiple locations are also measured. Findings show that working from home only on a day (full-day telework) decreases daily travel duration and increases the likelihood of avoiding peak hour travel for both work and non-work related travel. However, for homeworkers who also conduct work from their workplace on the same day (part-day telework), there is no reduction in daily travel time, and avoiding peak hour travel is limited to work-related travel. Working from other locations such as cafés/libraries or vehicles increases the likelihood of not traveling at peak hours. Findings also indicate that morning peak periods are more affected by work location decisions than evening peak periods. A survival analysis of daily departure times for both full-day and part-day homeworkers provides insight into this mechanism. We conclude on the basis of these findings that demand management policies and peak avoidance incentives would be more effective if they encourage both temporal and spatial flexibility for employees when partnering with regional employers. url: https://doi.org/10.1007/s11116-020-10136-6 doi: 10.1007/s11116-020-10136-6 id: cord-288051-wp8v2mc5 author: Sánchez-González, Álvaro title: What Should Be Known by a Urologist About the Medical Management of COVID-19’s Patients? date: 2020-09-01 words: 3616.0 sentences: 267.0 pages: flesch: 47.0 cache: ./cache/cord-288051-wp8v2mc5.txt txt: ./txt/cord-288051-wp8v2mc5.txt summary: Seven days after the clinical onset, the risk of transmission decreases in mildsymptomatic patients, but it may be extended over 24 days in severe cases [11•, 15] . The clinical spectrum of SARS-CoV-2 infection varies widely, including asymptomatic infection, mild upper respiratory tract illness, severe viral pneumonia with respiratory failure, and even death [9, 11•] (Fig. 1) . Corticosteroids are recommended in the treatment of septic shock, exacerbation of chronic obstructive respiratory disease and these COVID-19''s patients with respiratory deterioration and quick radiological progression associated with sings of cytokine storm (cytopenia, maintained fever, an increase of inflammatory reactants: D-dimer > 1000 ng/mL, ferritin > 1000 ng/mL, fibrinogen > 100 ng/mL, IL-6 > 40 pg/mL) [6, 23••] . Results from 237 patients, 158 assigned to remdesivir, showed no differences in time to clinical improvement, 28day mortality, oxygen support, hospitalization, or viral load. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Effective treatment of severe COVID-19 patients with tocilizumab abstract: PURPOSE OF REVIEW: The alarming number of confirmed COVID-19 cases put a strain on the healthcare systems, which had to reallocate human and technical resources to respond to the emergency. Many urologists became integrated into multidisciplinary teams, dealing with this respiratory illness and its unknown management. It aims to summarize the epidemiological, clinical, diagnostical, and therapeutical characteristics of COVID-19, from a practical perspective, to ease COVID-19 management to non-physician staff. RECENT FINDINGS: We performed a narrative review of the literature regarding COVID-19, updated to May 8th, 2020, at PubMed and COVID resource platforms of the main scientific editorials. COVID-19, characterized by fever, myalgias, dyspnea, and dry cough, varies widely from asymptomatic infection to death. Arrhythmias and thrombotic events are prevalent. Lymphopenia and inflammatory reactant elevation on laboratory, as well as bilateral and peripheral ground-glass opacities or consolidations on X-Ray, are usually found in its assessment. Little is known about SARS-CoV-2 immunology. To date, no therapy has demonstrated efficacy in COVID-19. Of-level or compassionate-use therapies are prescribed in the context of clinical trials. We should become familiar with specific adverse events and pharmacological interactions. SUMMARY: The COVID-19 pandemic has paralyzed the urological activity, and its long-term consequences are unpredictable. Despite not being used to deal with respiratory diseases, the urologists become easily qualified to manage COVID-19 by following protocols and being integrated into multidisciplinary teams, helping to overcome the pandemic. url: https://www.ncbi.nlm.nih.gov/pubmed/32870407/ doi: 10.1007/s11934-020-00995-y id: cord-304562-5xh4p786 author: Tanabe, Naoya title: Dupilumab maintenance therapy in an asthmatic patient with coronavirus disease 2019 pneumonia date: 2020-11-07 words: 667.0 sentences: 52.0 pages: flesch: 57.0 cache: ./cache/cord-304562-5xh4p786.txt txt: ./txt/cord-304562-5xh4p786.txt summary: Dupilumab is widely used as an important biologic 33 agent to control severe condition of asthma, eosinophilic chronic rhinosinusitis, 34 and atopic dermatitis. In the pandemic of severe acute respiratory 35 syndrome-coronavirus-2 (SARS-CoV-2) and its associated respiratory disease, clinical course is summarized in Figure 1 . On day12, chest 51 computed tomography (CT) showed bilateral peripheral-dominant ground glass 52 opacity (GGO) and consolidation ( Fig. 2A) , and because he had several risk 53 factors for severe COVID-19 including obesity and diabetes, he was transferred 54 to intensive care unit at our hospital and received oxygen therapy via face mask 55 (5-6 L/min). Then, mepolizumab Dupilumab is an essential biologic agent for severe type of asthma, 84 eosinophilic chronic rhinosinusitis, and atopic dermatitis. Type 2 inflammation modulates ACE2 and TMPRSS2 in airway 155 epithelial cells Asthma 166 exacerbation associated with COVID-19 pneumonia abstract: nan url: https://www.sciencedirect.com/science/article/pii/S132389302030143X?v=s5 doi: 10.1016/j.alit.2020.10.005 id: cord-007456-acbo4zs2 author: Thomas, L.H. title: Growth of Mycoplasma bovis in organ cultures of bovine foetal trachea and comparison with Mycoplasma dispar date: 2002-11-13 words: 2797.0 sentences: 142.0 pages: flesch: 52.0 cache: ./cache/cord-007456-acbo4zs2.txt txt: ./txt/cord-007456-acbo4zs2.txt summary: authors: Thomas, L.H.; Howard, C.J.; Parsons, K.R.; Anger, H.S. title: Growth of Mycoplasma bovis in organ cultures of bovine foetal trachea and comparison with Mycoplasma dispar Inoculation of tracheal organ cultures from bovine foetuses with Mycoplasma bovis resulted in a loss of cellular structure of the lamina propria, followed 20–22 days later by lifting and detachment of overlying epithelium. Ciliary activity was undiminished for up to 18 days following inoculation and little or no cytopathic effect on the ciliated epithelium was seen in spite of the close proximity of large numbers of organisms. bovis had virtually no cytopathic effect on the ciliated epithelium for 18 days following inoculation in spite of large numbers of organisms infiltrating between the columnar epithelium, accumulating in the lamina propria and amassing in the region of the basement membrane (Fig. 3) . abstract: Inoculation of tracheal organ cultures from bovine foetuses with Mycoplasma bovis resulted in a loss of cellular structure of the lamina propria, followed 20–22 days later by lifting and detachment of overlying epithelium. The effect was associated with large numbers of M. bovis, identified by immunoperoxidase labelling and electromicroscopy, infiltrating between the epithelial cells and amassing in the lamina propria, especially in the region of the basement membrane of the epithelium. Ciliary activity was undiminished for up to 18 days following inoculation and little or no cytopathic effect on the ciliated epithelium was seen in spite of the close proximity of large numbers of organisms. In contrast, M. dispar was restricted to the margin of the ciliated epithelium where, as previously reported, it caused pyknosis, sloughing and flattening of the epithelium with consequent loss of ciliary activity. The cytopathology observed for each mycoplasma bore a close similarity to the behaviour of the two mycoplasmas in vivo and it is suggested that the organ culture system may be a useful and relevant system to elucidate the pathogenic mechanisms for each mycoplasma. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117133/ doi: 10.1016/0378-1135(87)90044-7 id: cord-277077-kwaiorp8 author: Tița, Ovidiu title: Use of Yoghurt Enhanced with Volatile Plant Oils Encapsulated in Sodium Alginate to Increase the Human Body’s Immunity in the Present Fight Against Stress date: 2020-10-19 words: 8103.0 sentences: 433.0 pages: flesch: 58.0 cache: ./cache/cord-277077-kwaiorp8.txt txt: ./txt/cord-277077-kwaiorp8.txt summary: The main purpose of this paper is to create a yoghurt with high antioxidant capacity, using only raw materials from Romania; (2) Methods: The bioactive components used to enrich the cow milk yoghurt were extracted as volatile oils out of four aromatic plants: basil, mint, lavender and fennel. The 2,2-diphenyl-1-picrylhy-drazyl (DPPH) method was used to determine the antioxidant activity; (3) Results: The results show that cow milk yoghurt enhanced with volatile oils of basil, lavender, mint and fennel, encapsulated in sodium alginate has an antioxidant and antimicrobial effect as a staple food with multiple effects in increasing the body''s immunity. The antioxidant and antimicrobial activity of volatile fennel oil is offered by the high content of trans-anethole (63.30%), pinene (11.11%) and fenchone (8.32%) [20] [21] [22] [23] [24] [25] Basil (Ocimum basilicum) is an aromatic plant that belongs to the Lamiaceae family and is considered a rich source of essential oils. abstract: (1) Background: The COVID–19 pandemic and the imposition of strict but necessary measures to prevent the spread of the new coronavirus have been, and still are, major stress factors for adults, children, and adolescents. Stress harms human health as it creates free radicals in the human body. According to various recent studies, volatile oils from various aromatic plants have a high content of antioxidants and antimicrobial compounds. An external supply of antioxidants is required to destroy these free radicals. The main purpose of this paper is to create a yoghurt with high antioxidant capacity, using only raw materials from Romania; (2) Methods: The bioactive components used to enrich the cow milk yoghurt were extracted as volatile oils out of four aromatic plants: basil, mint, lavender and fennel. Initially, the compounds were extracted to determine the antioxidant capacity, and subsequently, the antioxidant activity of the yoghurt was determined. The 2,2-diphenyl-1-picrylhy-drazyl (DPPH) method was used to determine the antioxidant activity; (3) Results: The results show that cow milk yoghurt enhanced with volatile oils of basil, lavender, mint and fennel, encapsulated in sodium alginate has an antioxidant and antimicrobial effect as a staple food with multiple effects in increasing the body’s immunity. The antioxidant activity proved to be considerably higher than the control sample. The highest antioxidant activity was obtained on the first day of the analysis, decreasing onwards to measurements taken on days 10 and 20. The cow milk yoghurt enriched with volatile basil oil obtained the best results; (4) Conclusions: The paper shows that yoghurts with a high antioxidant capacity were obtained, using only raw materials from Romania. A healthy diet, compliance with safety conditions and finding appropriate and safe methods to increase the body’s immunity is a good alternative to a major transition through harder times, such as pandemics. The creation of food products that include natural antioxidant compounds combines both the current great possibility of developing food production in Romania and the prevention and reduction of the effects caused by pandemic stress in the human body. url: https://www.ncbi.nlm.nih.gov/pubmed/33086508/ doi: 10.3390/ijerph17207588 id: cord-000059-5hwqdnx1 author: Tokars, Jerome I. title: Enhancing Time-Series Detection Algorithms for Automated Biosurveillance date: 2009-04-17 words: 4407.0 sentences: 207.0 pages: flesch: 54.0 cache: ./cache/cord-000059-5hwqdnx1.txt txt: ./txt/cord-000059-5hwqdnx1.txt summary: At a constant alert rate of 1%, sensitivity was improved for both datasets by using a minimum standard deviation (SD) of 1.0, a 14–28 day baseline duration for calculating mean and SD, and an adjustment for total clinic visits as a surrogate denominator. These enhanced methods may increase sensitivity without increasing the alert rate and may improve the ability to detect outbreaks by using automated surveillance system data. For the DoD and hospital ED datasets, sensitivity was improved by using a higher minimum SD of 1.0, a longer baseline duration of 28 days, and adjusting for total visits. Stratifi cation by weekday versus weekend day improves expected value calculations when a substantial day-of-week effect exists, such as in the DoD data. Sensitivity of detecting various numbers of additional counts, by using initial versus best algorithms for hospital emergency department chief complaint data, for selected BioSense data. abstract: BioSense is a US national system that uses data from health information systems for automated disease surveillance. We studied 4 time-series algorithm modifications designed to improve sensitivity for detecting artificially added data. To test these modified algorithms, we used reports of daily syndrome visits from 308 Department of Defense (DoD) facilities and 340 hospital emergency departments (EDs). At a constant alert rate of 1%, sensitivity was improved for both datasets by using a minimum standard deviation (SD) of 1.0, a 14–28 day baseline duration for calculating mean and SD, and an adjustment for total clinic visits as a surrogate denominator. Stratifying baseline days into weekdays versus weekends to account for day-of-week effects increased sensitivity for the DoD data but not for the ED data. These enhanced methods may increase sensitivity without increasing the alert rate and may improve the ability to detect outbreaks by using automated surveillance system data. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671446/ doi: 10.3201/1504.080616 id: cord-257654-8u9m1k5q author: Tschöpe, Carsten title: Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis date: 2020-07-14 words: 6281.0 sentences: 370.0 pages: flesch: 43.0 cache: ./cache/cord-257654-8u9m1k5q.txt txt: ./txt/cord-257654-8u9m1k5q.txt summary: On the basis of the link between inflammation, fibrosis, aldosterone, and extracellular matrix regulation, we aimed to investigate the effect of an early intervention with the mineralocorticoid receptor antagonist (MRA) eplerenone on cardiac remodelling in a murine model of persistent coxsackievirus B3 (CVB3)‐induced myocarditis. 40 Because an uncontrolled early fulminant activated immune reaction together with aldosterone can trigger an irreversible cardiac damage with long-time consequences for cardiac remodelling and function in the post-inflammatory myocarditis phase, we sought to demonstrate whether an early intervention with the mineralocorticoid receptor antagonist (MRA) eplerenone (EPL) exerts cardio-beneficial effects to balance the inflammatory defence and healing reaction of the immune system in a murine model of persisting CVB3-induced myocarditis. However, no significant changes in nitrotyrosine staining were detected in any group at 28 days p.i. In vitro, EPL decreased the oxidative stress, depicted as DCF+ cells, in CVB3-infected HL-1 cardiomyocytes ( Figure 5E) . abstract: AIMS: Left ventricular (LV) dysfunction in viral myocarditis is attributed to myocardial inflammation and fibrosis, inducing acute and long‐time cardiac damage. Interventions are not established. On the basis of the link between inflammation, fibrosis, aldosterone, and extracellular matrix regulation, we aimed to investigate the effect of an early intervention with the mineralocorticoid receptor antagonist (MRA) eplerenone on cardiac remodelling in a murine model of persistent coxsackievirus B3 (CVB3)‐induced myocarditis. METHODS AND RESULTS: SWR/J mice were infected with 5 × 10(4) plaque‐forming units of CVB3 (Nancy strain) and daily treated either with eplerenone (200 mg/kg body weight) or with placebo starting from Day 1. At Day 8 or 28 post infection, mice were haemodynamically characterized and subsequently sacrificed for immunohistological and molecular biology analyses. Eplerenone did not influence CVB3 load. Already at Day 8, 1.8‐fold (P < 0.05), 1.4‐fold (P < 0.05), 3.2‐fold (P < 0.01), and 2.1‐fold (P < 0.001) reduction in LV intercellular adhesion molecule 1 expression, presence of monocytes/macrophages, oxidative stress, and apoptosis, respectively, was observed in eplerenone‐treated vs. untreated CVB3‐infected mice. In vitro, eplerenone led to 1.4‐fold (P < 0.01) and 1.2‐fold (P < 0.01) less CVB3‐induced cardiomyocyte oxidative stress and apoptosis. Furthermore, collagen production was 1.1‐fold (P < 0.05) decreased in cardiac fibroblasts cultured with medium of eplerenone‐treated vs. untreated CVB3‐infected HL‐1 cardiomyocytes. These ameliorations were in vivo translated into prevention of cardiac fibrosis, as shown by 1.4‐fold (P < 0.01) and 2.1‐fold (P < 0.001) lower collagen content in the LV of eplerenone‐treated vs. untreated CVB3‐infected mice at Days 8 and 28, respectively. This resulted in an early and long‐lasting improvement of LV dimension and function, as indicated by reduced LV end‐systolic volume and end‐diastolic volume, and an increase in LV contractility (dP/dt(max)) and LV relaxation (dP/dt(min)), respectively (P < 0.05). CONCLUSIONS: Early intervention with the MRA eplerenone modulates the acute host and defence reaction and prevents cardiac disease progression in experimental CVB3‐induced myocarditis without aggravation of viral load. The findings advocate for an initiation of therapy of viral myocarditis as early as possible, even before the onset of inflammation‐induced myocardial dysfunction. This may also have implications for coronavirus disease‐19 therapy. url: https://www.ncbi.nlm.nih.gov/pubmed/32662949/ doi: 10.1002/ehf2.12887 id: cord-347716-ka2lm62r author: Usher, Craigan title: Existential Returns date: 2020-06-25 words: 1532.0 sentences: 79.0 pages: flesch: 66.0 cache: ./cache/cord-347716-ka2lm62r.txt txt: ./txt/cord-347716-ka2lm62r.txt summary: In light of this and that we are one review short of the intended trio-this due to a child and adolescent psychiatry colleague needing to focus on leadership at her medical center (again, leaning into strengths)-I wished to share with you some thoughts on a favorite film. Groundhog Day tells the story of Pittsburgh meteorologist Phil Connors, who, alongside cameraman Larry, and TV producer Rita travels to Puxatawney, Pennsylvania, to film the annual Groundhog Day celebration. Groundhog Day illustrates many psychodynamic concepts and may speak to those of us whose mental lives are dominated by recurring thoughts of the existential, economic, and emotional hardships of others or questions like if or when schools and hospitals will return to "normal." In addition, the film suggests something that, at first glance, sounds quite odd: that doing the same thing over and over again is not, as some have said, the definition of insanity, but instead an insistence of hope. abstract: nan url: https://doi.org/10.1016/j.jaac.2020.05.002 doi: 10.1016/j.jaac.2020.05.002 id: cord-280821-kc0ut4oy author: Venturini, Elisabetta title: Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease date: 2020-09-24 words: 5481.0 sentences: 315.0 pages: flesch: 45.0 cache: ./cache/cord-280821-kc0ut4oy.txt txt: ./txt/cord-280821-kc0ut4oy.txt summary: The Italian Society of Pediatric Infectious Diseases steering and scientific committee developed a position paper on treatment of children with COVID-19, reviewing the current literature on this topic and providing indications based on the available literature data. Currently, American guidelines on COVID-19 treatment published in May 2020, recommend both in children and adults to use lopinavir/ritonavir only in the context of clinical trials, given the lack of effectiveness reported now in literature [9, 12] . The latest Chinese guidelines on SARS-Cov-2 pneumoniae do not recommend the use of a specific antiviral for the treatment of COVID-19, and nevertheless include lopinavir/ritonavir among the available therapeutic options for hospitalized patients [29] . In May 2020, following an assessment of the emergency use authorization criteria and available scientific evidence, the FDA issued an emergency use authorization allowing for the administration of remdesivir intravenously by health care providers for the treatment of COVID-19 suspected or laboratoryconfirmed in adults and pediatric patients hospitalized with severe disease [34] . abstract: A statement of consensus was formulated after reviewing available literature on pediatric treatment strategies for COVID-19 by the Steering and Scientific Committee of the Italian Society of Infectious Pediatric Diseases in connection with the Italian Society of Paediatrics. url: https://doi.org/10.1186/s13052-020-00900-w doi: 10.1186/s13052-020-00900-w id: cord-326143-6ndqgxy8 author: Wang, Qiang title: Successful recovery of severe COVID-19 with cytokine storm treating with extracorporeal blood purification date: 2020-05-26 words: 1325.0 sentences: 89.0 pages: flesch: 59.0 cache: ./cache/cord-326143-6ndqgxy8.txt txt: ./txt/cord-326143-6ndqgxy8.txt summary: COVID-19 associated cytokine storm could induce ARDS rapidly and the patients would require the support of mechanic ventilation. We present a case of severe SARS-CoV-2 infection who recovered from cytokine storm. The patients with confirmed COVID-19 progressed to acute respiratory distress syndrome (ARDS) rapidly in an incident rate as high as 41.8% 1 , and many of them require mechanic ventilation. Cytokines could be eliminated effectively by extracorporeal blood purification (EBP) 4 , which thus could interrupt the initiation and progression of inflammation cascade in the scenario of COVID-19. IL-6 (198.66 pg/ml) was almost 10 folds of normal range (≤5.9 pg/ml) which indicated an initiation of cytokine storm on day 12 ( Figure 1 ). The patient was largely stable until the chest distress exacerbated and blood in phlegm developed on day 14. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease abstract: COVID-19 associated cytokine storm could induce ARDS rapidly and the patients would require the support of mechanic ventilation. However, the prognosis was not that optimistic. The outcome might be changed if the intervention of EBP was performed timely. We present a case of severe SARS-CoV-2 infection who recovered from cytokine storm. url: https://www.sciencedirect.com/science/article/pii/S1201971220303726?v=s5 doi: 10.1016/j.ijid.2020.05.065 id: cord-299343-gsrgf4dd author: Wilson, A. M. title: Quantifying SARS-CoV-2 infection risk within the Apple/Google exposure notification framework to inform quarantine recommendations date: 2020-07-19 words: 10689.0 sentences: 493.0 pages: flesch: 48.0 cache: ./cache/cord-299343-gsrgf4dd.txt txt: ./txt/cord-299343-gsrgf4dd.txt summary: The conditional probability of current or future infectiousness, conditioned on how long post-exposure an exposed individual has been free of symptoms, decreases during quarantine, with shape determined by the distribution of incubation periods, proportion of asymptomatic cases, and distribution of asymptomatic shedding durations. Findings: As an example of our calculations, fifteen minutes of close contact with a high-shedding individual, given a 15% asymptomatic infection rate and no testing, would require 5and 14-day quarantine for their risk of current or future infectiousness to fall below 0.84% and 0.14% risk, respectively. A similarly maximal interaction, i.e. with 30 minutes in each attenuation bin, but with an index case at the minimum Transmission Risk level, corresponding to exposure timing that is not risk-free but falls just outside the window currently used by manual contact tracers, yields an infection probability of 0.36%, requiring 7 days of quarantine. abstract: Background: Bluetooth-based exposure notification apps can supplement manual contact tracing to reduce SARS-CoV-2 transmission. Their speed, scalability, and privacy preservation are generally acknowledged, but less exploited are smartphones' accurate measurement of duration, and ability to automatically calculate risk from multiple inputs. Methods: We model uncertainty in the shape of an exhaled virus-containing plume, inhalation parameters, and distance as a function of Bluetooth attenuation. We assume relative rates of viral shedding depend on the timing of exposure relative to symptom onset. We calibrate an exponential dose-response curve on the basis of the infection probabilities of household contacts. The conditional probability of current or future infectiousness, conditioned on how long post-exposure an exposed individual has been free of symptoms, decreases during quarantine, with shape determined by the distribution of incubation periods, proportion of asymptomatic cases, and distribution of asymptomatic shedding durations. It can be adjusted for negative test results using Bayes Theorem. Findings: As an example of our calculations, fifteen minutes of close contact with a high-shedding individual, given a 15% asymptomatic infection rate and no testing, would require 5- and 14-day quarantine for their risk of current or future infectiousness to fall below 0.84% and 0.14% risk, respectively. Interpretation: The Covid-Watch app is currently programmed either to use a threshold on initial infection risk to determine 14-day quarantine onset, or on the conditional probability of current and future infectiousness conditions to determine both quarantine and duration. Either threshold can be set by public health authorities. url: http://medrxiv.org/cgi/content/short/2020.07.17.20156539v1?rss=1 doi: 10.1101/2020.07.17.20156539 id: cord-282158-08u3x1z4 author: Yang, William H. title: Long-term immunogenicity of an AS03-adjuvanted influenza A(H1N1)pdm09 vaccine in young and elderly adults: An observer-blind, randomized trial() date: 2013-09-13 words: 5295.0 sentences: 252.0 pages: flesch: 49.0 cache: ./cache/cord-282158-08u3x1z4.txt txt: ./txt/cord-282158-08u3x1z4.txt summary: This large-scale, randomized study in subjects ≥18 years of age assessed whether one dose of AS03-adjuvanted 3.75 g HA influenza A(H1N1)pdm09 vaccine elicited immune response that met the US and European regulatory criteria. A single dose of the AS03-adjuvanted 3.75 g HA influenza A(H1N1)pdm09 vaccine elicited HI immune responses in the 18-64 years and >64 years age groups that met the CBER regulatory criteria at Day 21 ( Table 1 ). At Day 21, a single dose of the non-adjuvanted 15 g HA influenza A(H1N1)pdm09 vaccine elicited HI immune responses in subjects 18-64 years and >64 years of age that met the CBER regulatory criteria (Table 1) . Data from this large, controlled study in adults 18 years of age and older demonstrated that a single dose of AS03-adjuvanted or non-adjuvanted influenza A(H1N1)pdm09 vaccine elicited strong HI immune responses 21 days later that met the CHMP and the more stringent CBER criteria for pandemic influenza vaccines. abstract: BACKGROUND: This study (NCT00979602) evaluated the immunogenicity and relative protective efficacy of one dose of influenza A(H1N1)pdm09 vaccine with or without AS03 (an α-tocopherol oil-in-water emulsion based Adjuvant System). METHODS: Four thousands and forty-eight healthy adults aged ≥18 years were randomized (1:1) to receive one dose of either the adjuvanted split virion (3.75 μg hemagglutinin antigen [HA]/AS03) or non-adjuvanted (15 μg HA) vaccine. Hemagglutination inhibition [HI] antibody response was evaluated before vaccination and at Days 21, 42 and 182 (Month 6). Safety of the study vaccines was evaluated during the entire study duration. RESULTS: At Day 21, both study vaccines induced HI immune responses meeting the US regulatory criteria in subjects 18–64 years (seroprotection rate [SPR]: 98.0% [97.1–98.6]; seroconversion rate [SCR]: 89.7% [88.0–91.2] in the AS03-adjuvanted group; SPR: 91.4% [89.9–92.8]; SCR: 74.6% [72.3–76.9] in the non-adjuvanted group) and >64 years of age (SPR: 86.0% [82.5–89.0]; SCR: 75.3% [71.1–79.2] in the AS03-adjuvanted group; SPR: 69.1% [64.6–73.3]; SCR: 56.7% [52.0–61.3] in the non-adjuvanted group). The AS03-adjuvanted vaccine induced higher HI geometric mean titers than the non-adjuvanted vaccine at all time points. At Month 6, only subjects 18–64 years of age from both vaccine groups still met the US regulatory criteria (SPR: 82.1% [80.0–84.1]; SCR: 62.3% [59.6–64.8] in the AS03-adjuvanted group; SPR: 75.3% [72.9–77.5]; SCR: 53.7% [51.0–56.4] in the non-adjuvanted group). Protective efficacy was not evaluated due to low number of RT-qPCR-confirmed A(H1N1)pdm09 influenza cases. Through Month 12, 216 serious adverse events (in 157 subjects: 84 in the AS03-adjuvanted and 73 in the non-adjuvanted group) and 12 potentially immune mediated diseases (5 in the AS03-adjuvanted and 7 in the non-adjuvanted group) were reported. CONCLUSION: A single dose of either adjuvanted or non-adjuvanted influenza A(H1N1)pdm09 vaccine induced protective HI antibody levels against the A/California/7/2009 strain that persisted through Month 6 in the 18–64 years population. url: https://www.sciencedirect.com/science/article/pii/S0264410X13009286 doi: 10.1016/j.vaccine.2013.07.007 id: cord-310249-cvv77f10 author: Yule, Terecita D. title: Canine parvovirus vaccine elicits protection from the inflammatory and clinical consequences of the disease date: 1997-05-31 words: 4606.0 sentences: 247.0 pages: flesch: 45.0 cache: ./cache/cord-310249-cvv77f10.txt txt: ./txt/cord-310249-cvv77f10.txt summary: In canine parvovirus infected puppies we measured the levels of acute phase proteins and changes in leukocyte phenotypes and cell trafficking by flow cytometry. In this study we evaluated whether measuring levels of acute phase proteins and investigating changes in leukocyte phenotypes by flow cytometry would complement conventional clinical assessment of a vaccine efficacy study. The association of these parameters with the major clinical signs of parvovirus induced disease in vaccinated vs nonvaccinated animals is described for seropositive puppies given a CPV-2 vaccine followed by experimental infection with CPV-2b. Low but significant SAA values were observed in three vaccinates on sporadic days post-challenge, but these values did not coincide with clinical signs, virus shed or hematologic changes. Using cell specific antibodies and flow cytometric analysis, a mean of 88% of leukocytes in peripheral Days Post CPV-2 Challenge blood were positively identified as T-cells (CD4+ and CD@, pan-T), B-cells, monocytes, and neutrophils when compared to the absolute leukocyte count obtained conventionally. abstract: Abstract Inflammatory changes following infection are central to the clinical manifestation of disease. However, information regarding such changes in animal disease is limited. In canine parvovirus infected puppies we measured the levels of acute phase proteins and changes in leukocyte phenotypes and cell trafficking by flow cytometry. These parameters correlated with conventional assessment of clinical disease in a vaccine efficacy study. Seropositive (CPV-2) 6-week-old puppies given three doses of a CPV-2 containing vaccine developed significant antibody titers and remained healthy after experimental infection with CPV-2b. Unvaccinated controls developed clinical signs and shed virus. Importantly, acute phase proteins became elevated, and lymphopenia, neutropenia and modulation of neutrophil-CD4 were detected in controls but not in vaccinates. url: https://api.elsevier.com/content/article/pii/S0264410X96002320 doi: 10.1016/s0264-410x(96)00232-0 id: cord-001262-8s7g2wvd author: Zheng, Guoping title: Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study date: 2014-04-04 words: 4924.0 sentences: 286.0 pages: flesch: 52.0 cache: ./cache/cord-001262-8s7g2wvd.txt txt: ./txt/cord-001262-8s7g2wvd.txt summary: title: Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study The objectives of this study were first to examine the possible adverse events after systemic administration of allogeneic adipose-derived MSCs in ARDS patients and second to determine potential efficacy of MSCs on ARDS. METHODS: Twelve adult patients meeting the Berlin definition of acute respiratory distress syndrome with a PaO(2)/FiO(2) ratio of < 200 were randomized to receive allogeneic adipose-derived MSCs or placebo in a 1:1 fashion. Many studies, including publications from our group [11, 12] , have demonstrated compelling evidence of the benefits of MSCs from both bone marrow [13] [14] [15] and adipose tissues [16] [17] [18] in animal models for lung injury and ARDS. In this randomized, placebo-controlled phase I clinical trial, the primary goal was to evaluate the safety and feasibility of systemic administration of allogeneic adipose-derived MSCs in ARDS patients. abstract: BACKGROUND: Recent studies have demonstrated that mesenchymal stem cells (MSCs) modulate the immune response and reduce lung injury in animal models. Currently, no clinical studies of the effects of MSCs in acute respiratory distress syndrome (ARDS) exist. The objectives of this study were first to examine the possible adverse events after systemic administration of allogeneic adipose-derived MSCs in ARDS patients and second to determine potential efficacy of MSCs on ARDS. METHODS: Twelve adult patients meeting the Berlin definition of acute respiratory distress syndrome with a PaO(2)/FiO(2) ratio of < 200 were randomized to receive allogeneic adipose-derived MSCs or placebo in a 1:1 fashion. Patients received one intravenous dose of 1 × 10(6) cells/kg of body weight or saline. Possible side effects were monitored after treatment. Acute lung injury biomarkers, including IL-6, IL-8 and surfactant protein D (SP-D), were examined to determine the effects of MSCs on lung injury and inflammation. RESULTS: There were no infusion toxicities or serious adverse events related to MSCs administration and there were no significant differences in the overall number of adverse events between the two groups. Length of hospital stay, ventilator-free days and ICU-free days at day 28 after treatment were similar. There were no changes in biomarkers examined in the placebo group. In the MSCs group, serum SP-D levels at day 5 were significantly lower than those at day 0 (p = 0.027) while the changes in IL-8 levels were not significant. The IL-6 levels at day 5 showed a trend towards lower levels as compared with day 0, but this trend was not statistically significant (p = 0.06). CONCLUSIONS: Administration of allogeneic adipose-derived MSCs appears to be safe and feasible in the treatment of ARDS. However, the clinical effect with the doses of MSCs used is weak, and further optimization of this strategy will probably be required to reach the goal of reduced alveolar epithelial injury in ARDS. TRIAL REGISTRATION: Clinical trials.gov, NCT01902082 url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994204/ doi: 10.1186/1465-9921-15-39 id: cord-256015-tt58n0jk author: Zhu, Juanjuan title: Clinical characteristics and therapeutic procedure for a critical case of novel coronavirus pneumonia treated with glucocorticoids and non-invasive ventilator treatment date: 2020-06-01 words: 1344.0 sentences: 71.0 pages: flesch: 52.0 cache: ./cache/cord-256015-tt58n0jk.txt txt: ./txt/cord-256015-tt58n0jk.txt summary: title: Clinical characteristics and therapeutic procedure for a critical case of novel coronavirus pneumonia treated with glucocorticoids and non-invasive ventilator treatment Herein, we report the clinical characteristics and diagnosis of a patient with severe NCP who was treated with glucocorticoids and non-invasive ventilation. The results indicated that the levels of IL-6 and C-reactive protein had decreased with the increase in the dosage and duration of methylprednisolone therapy and returned to normal on February 10. On the 19 th day of admission, a nasopharyngeal swab was performed for the first time after the treatment and the test result was negative for 2019-nCoV infection. In addition, the levels of IL-6 and C-reactive protein returned to normal on day 8 of methylprednisolone use. Glucocorticoids and non-invasive ventilator treatment could significantly improve the clinical symptoms in critically ill patients with NCP. abstract: The novel coronavirus pneumonia (NCP) outbreak occurred in Wuhan, China at the end of 2019. Here, we report the clinical characteristics and therapeutic procedure for a case of severe NCP. The patient was started on glucocorticoids and non-invasive ventilator treatment. After treatment, the patient’s symptoms improved, and the status was confirmed as NCP negative. Our results may provide clues for the treatment of NCP. url: https://www.ncbi.nlm.nih.gov/pubmed/32491104/ doi: 10.1590/0037-8682-0227-2020 id: cord-266571-qbskh1uu author: de Arriba, M.L title: Lymphoproliferative responses and protection in conventional piglets inoculated orally with virulent or attenuated porcine epidemic diarrhoea virus date: 2002-06-04 words: 5103.0 sentences: 217.0 pages: flesch: 42.0 cache: ./cache/cord-266571-qbskh1uu.txt txt: ./txt/cord-266571-qbskh1uu.txt summary: Lymphocyte proliferative responses were evaluated in mucosal (mesenteric lymph nodes) and systemic (spleen and blood) lymphoid tissues of conventional piglets inoculated with the virulent or attenuated isolates of porcine epidemic diarrhoea virus (PEDV) strain CV-777 and challenged 21 days later with the virulent isolate of the same virus. Virus-specific lymphoproliferative responses of systemic tissues (spleen and blood) and mesenteric lymph nodes were studied in conventional piglets after primary inoculation with the virulent, wild type, strain CV-777 of PEDV or its cell culture attenuated form and after challenge, 3 weeks later, with a high dose of the virulent virus. Correlations between lymphocyte proliferative responses in mononuclear cells collected from mesenteric lymph nodes, blood and spleen from pigs inoculated with virulent or attenuated PEDV or mock-inoculated and protection against challenge 21 days later with virulent PEDV. abstract: Lymphocyte proliferative responses were evaluated in mucosal (mesenteric lymph nodes) and systemic (spleen and blood) lymphoid tissues of conventional piglets inoculated with the virulent or attenuated isolates of porcine epidemic diarrhoea virus (PEDV) strain CV-777 and challenged 21 days later with the virulent isolate of the same virus. A lymphoproliferative assay was developed in which mononuclear cells isolated from lymphoid tissues at different postinoculation and postchallenge days underwent a secondary in vitro stimulation with semipurified antigen obtained from PEDV-infected cell cultures. Vigorous lymphocyte proliferative responses were detected in the pigs inoculated with the virulent PEDV at postinoculation days 4–21, especially in the mesenteric lymph nodes and the blood; however, in the spleen this response was lower and less regular. The pigs inoculated with the attenuated virus showed a less intense response, the higher lymphocyte proliferation also corresponded to the mononuclear cells from mesenteric lymph nodes. Lymphocyte proliferation responses showed high correlations with protection against homologous challenge with virulent PEDV, and this correlation was higher in the gut associated lymphoid tissues (mesenteric lymph nodes). The cell proliferation response detected in blood mirrored that detected in the mesenteric lymph nodes, and showed also good correlation with protection. The results confirm that T-cell-helper function, assessed by lymphocyte proliferation responses, contributes to establishing a protective immune response against PEDV infections. url: https://www.sciencedirect.com/science/article/pii/S0166093402000630 doi: 10.1016/s0166-0934(02)00063-0 id: cord-034257-kl2ccmz5 author: de Jonge, Jeroen C. title: PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment date: 2020-10-26 words: 3731.0 sentences: 209.0 pages: flesch: 51.0 cache: ./cache/cord-034257-kl2ccmz5.txt txt: ./txt/cord-034257-kl2ccmz5.txt summary: title: PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment AIMS AND DESIGN: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke (PRECIOUS) is an international, multi-centre, 3 × 2 factorial, randomised, controlled, open-label clinical trial with blinded outcome assessment, which will assess whether prevention of aspiration, infections, or fever with metoclopramide, ceftriaxone, paracetamol, respectively, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in elderly patients with acute stroke. The primary objective is to assess whether prevention of aspiration, infections, or fever with metoclopramide, ceftriaxone, paracetamol, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in older patients with acute stroke. abstract: RATIONALE: Aspiration, infections, and fever are common in the first days after stroke, especially in older patients. The occurrence of these complications has been associated with an increased risk of death or dependency. AIMS AND DESIGN: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke (PRECIOUS) is an international, multi-centre, 3 × 2 factorial, randomised, controlled, open-label clinical trial with blinded outcome assessment, which will assess whether prevention of aspiration, infections, or fever with metoclopramide, ceftriaxone, paracetamol, respectively, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in elderly patients with acute stroke. DISCUSSION: This statistical analysis plan provides a technical description of the statistical methodology and unpopulated tables and figures. The paper is written prior to data lock and unblinding of treatment allocation. TRIAL REGISTRATION: ISRCTN registry ISRCTN82217627. Registered on 22 September 2015. The trial was prospectively registered. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586648/ doi: 10.1186/s13063-020-04717-0 id: cord-005453-4057qib7 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 words: 275771.0 sentences: 16876.0 pages: flesch: 56.0 cache: ./cache/cord-005453-4057qib7.txt txt: ./txt/cord-005453-4057qib7.txt summary: To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective, observational cohort study enrolled in 21 HID-SCT and 13 MSD-SCT recipients. The aim of this study is to identify the prognostic impact of pre-transplant TIM3 levels on early and late transplant related complications as well as post-transplant relapse and survival Methods: A total of 177 hematopoietic stem cell transplantation (HSCT) recipients with an initial diagnosis of acute leukemia [median age: 36(16-66) years; male/ female: 111/66] were included in the study. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091813/ doi: 10.1038/s41409-019-0559-4 id: cord-005460-ezrn8cva author: nan title: Physicians – Poster Session date: 2017-07-28 words: 287105.0 sentences: 15681.0 pages: flesch: 56.0 cache: ./cache/cord-005460-ezrn8cva.txt txt: ./txt/cord-005460-ezrn8cva.txt summary: Still the optimal combination of immunosuppressive agents with PTCy should be elucidated for different types of SCTs. We report the 2-year update of the prospective NCT02294552 single-center trial that evaluated risk-adapted graft-versushost disease (GVHD) prophylaxis with PTCy in related, unrelated and haploidentical SCTs. 200 adult patients (median age 32 y.o., range: 18-62) with hematologic malignancies, including AML (47.5%), ALL (26.5%), CML (10.5%), MDS (4%), and lymphomas (11.5%), were enrolled in the study. Long-term follow-up from the prospective randomized phase III multicenter trial comparing a standard GvHD prophylaxis with cyclosporine A and methotrexate with or without additional pretransplant ATLG (Grafalon, previously ATG-FRESENIUS S) (given 20 mg/kg/day, days − 3 to − 1) in unrelated donor hematopoietic cell transplantation after myeloablative conditioning resulted in a significant reduction of acute and chronic GvHD without compromising relapse rate and survival [1, 2, 3] . abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091844/ doi: 10.1038/bmt.2017.134 id: cord-005478-5iu38pr6 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session date: 2019-07-03 words: 63350.0 sentences: 3869.0 pages: flesch: 58.0 cache: ./cache/cord-005478-5iu38pr6.txt txt: ./txt/cord-005478-5iu38pr6.txt summary: There were some differences among groups: patients in group-1 were younger (median age 46 years, p< 0.02) were transplanted in more recent year (2015, p< 0.001), received more frequently a regimen based on TBF (thiotepa, fludarabine and busulfan) (83%, p< 0.001) and bone marrow (BM) as source of stem cells (77%, p< 0.001), with no ATG (100%, p< 0.001). Clinical Trial Registry: NCT01217723 Disclosure: None of the Authors have any conflicts of interest to declare O105 Immune reconstitution -based score at diagnosis of CGVHD predicts GVHD severity and overall-survival: A novel prognostication tool for GVHD treatment tailoring Background: Allogeneic stem cell transplantation (HSCT) survivors are at a relevant risk of developing chronic GvHD (cGvHD), which importantly affects quality of life and increases morbidity and mortality. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092200/ doi: 10.1038/s41409-019-0562-9 id: cord-005497-w81ysjf9 author: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 words: 103623.0 sentences: 6176.0 pages: flesch: 53.0 cache: ./cache/cord-005497-w81ysjf9.txt txt: ./txt/cord-005497-w81ysjf9.txt summary: The positive NC group had more plasma transfusion (p-value 0.03) and a lower median hematocrit at 24 hrs (p-value 0.013), but similar hospital length of stay (p=0.17) and mortality rate (p=0.80) Conclusions: NC at ICU admission identifies subclinical AKI in TBI patients and it maight be used to predictclinical AKI. In patients with pneumonia requiring intensive care (ICU) admission, we hypothesise that abnormal right ventricular (RV) function is associated with an increased 90-day mortality. The objective of this study was to describe the incidence of each AKI stages as defined by KDIGO definition (with evaluation of urine output, serum creatinine and initiation of renal replacement therapy (RRT)), in a mixed medical and surgical population of patients hospitalized in ICU and PCU over a 10-year period (2008-2018). This study aimed at investigating the relationship of goal-directed energy and protein adequacy on clinical outcomes which includes mortality, intensive care unit(ICU) and hospital length of stay (LOS), and length of mechanical ventilation (LOMV). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092506/ doi: 10.1186/s13054-020-2772-3 id: cord-005646-xhx9pzhj author: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 words: 72031.0 sentences: 4734.0 pages: flesch: 56.0 cache: ./cache/cord-005646-xhx9pzhj.txt txt: ./txt/cord-005646-xhx9pzhj.txt summary: Aims and methods The aim of both a prospective and retrospective survey conducted in German pediatric intensive care units in 1993 was to accumulate data on the epidemiology, risk factors, natural history and treatment strategies in a large group of pediatric ARDS patients who were treated in the tt~ee year period from 1991 to 1993.All patients had acute bilateral alveolar infiltration of noncardiogenic origin and a pO2~iO2 ratio < 150mmHg. The influence of sex, underlying disease and single organ failure was analyzed using the Fischer''s exact test, the influence of additional organ failure on mortality was tested with the Cochran-Mantel-Haenszet statistics. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095092/ doi: 10.1007/bf02316512 id: cord-005727-li8pwigg author: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 words: 102770.0 sentences: 6408.0 pages: flesch: 53.0 cache: ./cache/cord-005727-li8pwigg.txt txt: ./txt/cord-005727-li8pwigg.txt summary: Since, continuous epidural analgesia provides the required level of analgesia to support early mobilization and significant reduction in pulmonary and cardiovascular morbidity in the early postoperative period, we postulated that the use of low dose of continuous epidural morphine might improve postoperative analgesia and reduce undesirable side effects in elderly patientsTherefore, the present study was designed to evaluate the effects of morphine administered via epidural patients controlled analgesia and intravenous tramadol + metamizol on postoperative pain control and side effects in elderly patients after major abdominal surgery. For each ventilated patient the following data was registered:Age, APACHE II, the reason of admission, risk factors, use NIV, MV duration, timing of tracheostomy, time of diagnosis of VAP, microbiological data, length of stay and mortality in ICU. 23rd ESICM ANNUAL CONGRESS -BARCELONA, SPAIN -9-13 OCTOBER 2010 S131 Evaluated factors: patient characteristics, signs, symptoms, abscess location, time between symptoms and hospital admission and surgery, lab results, microbiology, antibiotic therapy, APACHE2, SAPS2, SOFA, length of ICU stay, surgical re-intervention, duration of mechanical ventilation, infectious complications, critical illness myopathy (CIM), renal replacement therapy (RRT), re-intubation, tracheotomy, mortality. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095301/ doi: 10.1007/s00134-010-1999-x id: cord-005777-6rvfsx4p author: nan title: PS 0420-0716 date: 2007-08-25 words: 59217.0 sentences: 3634.0 pages: flesch: 53.0 cache: ./cache/cord-005777-6rvfsx4p.txt txt: ./txt/cord-005777-6rvfsx4p.txt summary: We prospectively recorded data of all patients who were newly diagnosed with AF and all those with a septic shock on a surgical ICU (no cardiac surgery) during a one year period according to the requirements of the local ethical committee. Our aim was to evaluate the predictive role of admission APACHE II, admission and total maximum SOFA score, hypoalbuminemia, increased serum creatinine, C-reactive protein, lactate, and serum blood glucose for the 30-day mortality of septic patients admitted to medical ICU. The aim of this study was to analyze the clinical presentation and to evaluate mortality associated factors (timing and accurancy of diagnosis, timing of surgery, severity score and organ failure, surgical and medical treatments). Data were extracted independently to assess intention to treat intensive care unit (ICU) and hospital mortality, days of mechanical ventilation, length of stay, incidence of ventilator-associated pneumonia and pneumothorax, and associated complications of the implemented intervention. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095424/ doi: 10.1007/s00134-007-0823-8 id: cord-005814-ak5pq312 author: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179164.0 sentences: 12028.0 pages: flesch: 56.0 cache: ./cache/cord-005814-ak5pq312.txt txt: ./txt/cord-005814-ak5pq312.txt summary: Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095534/ doi: 10.1007/bf02426401 id: cord-005816-i54q5gsu author: nan title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 words: 83124.0 sentences: 5617.0 pages: flesch: 53.0 cache: ./cache/cord-005816-i54q5gsu.txt txt: ./txt/cord-005816-i54q5gsu.txt summary: Several factors such as the initial lack of symptoms, a low diagnostic sensitivity of the CT (34% false negatives), and the nonoperative management of solid organ injuries, have contributed to a delayed diagnosis in one of every five patients in our series, but this has not led to a significant increase in septic complications in this group. Method: The demographic features, the treatments, the intensity of the illness and mortality rate of the 155 patients in Afyon Kocatepe University General Surgery clinic between the years 2006 Background: Enterocutaneous fistula continues to be a serious surgical problem. Introduction: In our previous study, we examined the treatment results of burn patients older than 45 years, and found a significant increase in mortality with increasing age groups. Methods: Data on emergency surgical cases and admissions to the surgical service over a 3-month period were collected and analyzed; this included patient demographics, referral sources, diagnosis, operation, and length of stay (LOS Conclusion: Emergency workload represents a significant part of the work for the general surgeons. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095784/ doi: 10.1007/s00068-009-8001-z id: cord-006182-kck5e1ry author: nan title: 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date: 2019-10-01 words: 87645.0 sentences: 4817.0 pages: flesch: 46.0 cache: ./cache/cord-006182-kck5e1ry.txt txt: ./txt/cord-006182-kck5e1ry.txt summary: The primary objective of COGiTATE (CppOpt GuIded Therapy Assessment of Target Effectiveness) is to demonstrate feasibility of individualising CPP at CPPopt in TBI patients, expressed as the percentage of monitoring time for which CPP is within 5 mmHg of regularly updated CPPopt targets during the first 5 days of Intensive Care Unit (ICU) admission. Neurocritical care has become increasingly subspecialized.Yet, due to limited availability of dedicated Neurocritical Care units (NCCUs), often patients may need to be admitted to ICUs other than NCCUs. This survey based study was conducted to explore self-reported knowledge in recognizing and managing some common neurological emergencies such as stroke, status epilepticus, raised intracranial pressure etc among critical care nurses at a Comprehensive Stroke Center. Coagulation factor Xa (recombinant), inactivated-Xa inhibitor associated life--factor prothrombin complex concentrate (PCC) was utilized offRetrospective, single center, cohort study including adult intracranial hemorrhage patients who received discharge between efficacy (defined by International Society on Thrombosis and Haemostasis criteria), thrombotic events, ICU and hospital length of stay, and mortality. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100118/ doi: 10.1007/s12028-019-00857-7 id: cord-006391-esnsa4u5 author: nan title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 words: 44844.0 sentences: 2433.0 pages: flesch: 50.0 cache: ./cache/cord-006391-esnsa4u5.txt txt: ./txt/cord-006391-esnsa4u5.txt summary: In our parallel tests using an excision-sample technique [2] which is considerably more sensitive than the DGHM procedure, we have observed the following mean reductions in the counts of accessible bacteria: iodine in ethanol, 96%; povidone-iodine, 89%; chlorhexidine in ethanol, 88%; iso-propanol, The purpose of this study was to compare radiation injury in Guinea Pig small bowel (1) devoid of contents (2) containing bile (3) containing pancreatic juice. Studies in vitro employing isolated perfused rat pancreas and stomach revealed following results: Mean basal pancreatic somatostatin release in normal, diabetic and transplanted rats were 12___3, 24-t-7, and 17__+4 pg/ml, respectively. As these changes appear closely correlated to the blood glucose levels which show a 30 % decrease at 4 h and progressive restoration towards normal values up to 24 h, attempts have been made to alter the insulin/glucagon ratio by glucose infusion after PH and study its relation to liver regeneration. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101735/ doi: 10.1007/bf01279099 id: cord-006444-eq56zhtd author: nan title: Abstracts of oral presentations and posters date: 1993 words: 40668.0 sentences: 2121.0 pages: flesch: 53.0 cache: ./cache/cord-006444-eq56zhtd.txt txt: ./txt/cord-006444-eq56zhtd.txt summary: The results from ongoing preclinical studies continue to confirm the broad spectrum of biological activities possessed by rhiL-1 1 in vitro and suggest this cytokine may be an effective agent in the treatment of myelosuppression associated with cancer chemotherapy and bone marrow transplantation. We performed a phase H trial to assess the ability of G-CSF -mobilized PBPC to rapidly and completely restore hemopeiesis after high dose chemotherapy in the absence of bone marrow infusions, with selection for PBPC-only infusions based on yield of granulocyte -macrophage colony -forming cells (GM-CFC) after G-CSF treatment. Our approach for high-dose (HD) chemotherapy is to first treat patients eligible for dose intensification with a standard dose chemotherapy (VIP: VP26 = etoposide: 500 mg/m 2, ifosfamide: 4 g/m 2, cis-platinum: 50 mg/m 2) followed by the application of colony stimulating factors (G-CSF, GM-CSF or IL-3 + GM-CSF) in order to combine a regimen with broad anti-tumor activity with the recruitment of peripheral blood progenitor cells (PBPCs). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101830/ doi: 10.1007/bf01695978 id: cord-006849-vgjz74ts author: nan title: 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date: 2019-09-13 words: 222162.0 sentences: 14023.0 pages: flesch: 48.0 cache: ./cache/cord-006849-vgjz74ts.txt txt: ./txt/cord-006849-vgjz74ts.txt summary: Methods: We are performing this procedures within a prospective randomized trial that is design to compare the long term results of LRYGB-B versus the standard laparoscopic Roux-en-Y gastric bypass.The video shows our technique in a case of a 46 years old female with a BMI of 46 Kg/m2. Material and methods: We present a video of the surgical intervention of a 32-year-old patient, with functional dyspepsia, with a casual diagnosis of a pseudocystic mass of the right colon after performing a CT scan: giant diverticulum of the hepatic colon angle with fecaloid content inside it under tension The patient goes to the emergency room for acute abdominal pain, pending colonoscopy, antibiotic treatment is established, and a laparoscopic approach is decided upon after the patient''s evolution. Method: We present the case of a 65-year-old patient with surgical antecedent of laparoscopic low anterior resection due to rectal cancer, presenting in postoperative period an anastomosis leakage with severe peritonitis was identified and a laparotomy with end colostomy was performed. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103177/ doi: 10.1007/s00464-019-07109-x id: cord-006856-b1w25ob5 author: nan title: 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date: 2005 words: 29625.0 sentences: 1983.0 pages: flesch: 52.0 cache: ./cache/cord-006856-b1w25ob5.txt txt: ./txt/cord-006856-b1w25ob5.txt summary: Egr-1 and hypoxia-inducible factor-1 (HIF-1) gene expression was examined in left ventricular biopsies of explanted failing hearts in 28 ICM and 42 DCM patients, as well as in 12 donor grafts before reperfusion (control), at 10, 30, 60 minutes after reperfusion, and at 1, 2, 3, 4, 6, 12 posttransplant weeks, using real-time RT-PCR. The risk of transplant-related mortality (TRM) due to graft-versushost disease (GvHD) is higher in male recipients of female stem cells compared with female patients receiving a graft from a female donor. We therefore analyzed a single-center cohort of 72 high-risk patients transplanted with a related or unrelated stem cell graft after nonmyeloablative conditioning for outcome (acute and chronic GvHD, TRM, relapse, and survival). Four patients between the age of 34 and 44 years underwent allogeneic peripheral blood stem cell (PBSC) transplantation (SCT) from HLA-identical sibling or unrelated donors at our institution. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103192/ doi: 10.1007/s10353-005-0216-6 id: cord-006870-f5w6fw6q author: nan title: Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting date: 2017-09-19 words: 122221.0 sentences: 6828.0 pages: flesch: 47.0 cache: ./cache/cord-006870-f5w6fw6q.txt txt: ./txt/cord-006870-f5w6fw6q.txt summary: Subjective perceptions of recovery were assessed via responses to the forced-choice dichotomized question, "Do you feel that you have made a complete recovery from the arrest?"Objective outcome measures of recovery included: Repeatable Battery for Neuropsychological Status (RBANS), Modified Lawton Physical Self-Maintenance Scale (L-ADL), Barthel Index (BI), Cerebral Performance Category Scale (CPC), Center for Epidemiological Studies-Depression scale (CES-D), and Post traumatic stress disorder-checklist (PTSD-C). Utilizing data from the Citicoline Brain Injury Treatment (COBRIT) trial, a prospective multicenter study, we identified 224 patients who met the inclusion criteria; 1) placement of an ICP monitoring device, 2) Glasgow coma score (GCS) less than 9, 3) EVD placement prior to arrival or within 6 hours of arrival at the study institution. The objective of this study was to examine the incidence rates of pre-specified medical and neurological ICU complications, and their impact on post-traumatic in-hospital mortality and 12month functional outcomes. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103238/ doi: 10.1007/s12028-017-0465-9 id: cord-006876-v2m5l5wz author: nan title: Neurocritical Care Society 14(th) Annual Meeting date: 2016-08-11 words: 59719.0 sentences: 3440.0 pages: flesch: 47.0 cache: ./cache/cord-006876-v2m5l5wz.txt txt: ./txt/cord-006876-v2m5l5wz.txt summary: We conducted a prospective cohort study among mild and moderate-severe TBI patients admitted to a level 1 trauma center with these inclusion criteria: 1) Age < 65 years, 2) No severe non-TBI injuries, 3) No prior cardiac disease, and 4) Minimal comorbidities. In most instances, DC has been performed based on neurosurgical evaluation of the patient with or without intracranial pressure (ICP) monitoring and evidence of increased shown variable outcomes in emergency (within 4 hours of injury) neurosurgical procedure in Traumatic Brain Injury (TBI). This is an observational cohort study of adult patients (>18 years) in a 10-bed NSICU at an academic, tertiary care center evaluating quality outcome measures pre-and post-neurointensivists. Intensivists in neuro ICU must consistently assess and treat the non-neurological complications in traumatic brain and spine-injured patients and deliver appropriate care to bring down the mortality and morbidity and improve outcome. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103251/ doi: 10.1007/s12028-016-0301-7 id: cord-006880-9dgmdtj8 author: nan title: Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date: 2012-09-19 words: 82351.0 sentences: 4528.0 pages: flesch: 49.0 cache: ./cache/cord-006880-9dgmdtj8.txt txt: ./txt/cord-006880-9dgmdtj8.txt summary: Patients initially comatose after cardiac arrest treated who awoke after therapeutic hypothermia (TH) were evaluated by a neuropsychologist prior to hospital discharge with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), a well-validated tool that assesses function in multiple domains compared to standardized normal values. Clinical data including the pre-admission-status, neuroradiological, initial presentation, treatment, and outcome were evaluated through institutional databases, patient''s medical charts and by mailed questionnaires. To determine the differences in hospital outcomes among adult mild traumatic brain injury (TBI) patients where the severity of TBI is defined by Glasgow Coma Scale (GCS) score. Retrospective chart analysis was performed on all adult patients arriving to emergency department with history of fall at a level one trauma center for parameters like vomiting, alteration of consciousness (AOC) & loss of consciousness (LOC) after TBI; post-traumatic amnesia (PTA) and history of seizures before or after injury, along with outcomes such as ICU admission & ICU length of stay. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103259/ doi: 10.1007/s12028-012-9775-0 id: cord-010119-t1x9gknd author: nan title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date: 2017-09-04 words: 230193.0 sentences: 13234.0 pages: flesch: 55.0 cache: ./cache/cord-010119-t1x9gknd.txt txt: ./txt/cord-010119-t1x9gknd.txt summary: Conclusion: The wide distribution in the concentration of bioactive lipids among 405 stored RBC units suggests that lipid degradation is highly donor-Background/Case Studies: To ensure availability of biological products to hospitals, blood banks have developed and validated multiple storage conditions for each of their products to maximize shelf life and quality. 1 The Department of Blood Transfusion, The PLA General Hospital, 2 The Department of Blood Transfusion, Air Force General Hospital, PLA Background/Case Studies: Recently, multi researches have reported that longer term-stored red blood cells(RBCs) units were associated with increased risks of clinically adverse events, especially in critically ill patients. Weak D types 1, 2 and 3 express all the major RhD epitopes and these patients can be managed as RhD-positive, which may lead to a reduction in unnecessary Rh immunoglobulin (RhIG) administration and conservation of RhD-negative RBCs. Study Design/Method: RHD genotyping was performed on all patient samples with weaker than expected or discrepant RhD typing results, utilizing a commercially available genotyping kit manufactured by Immucor (RHD BeadChip). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169716/ doi: 10.1111/trf.14286 id: cord-014976-546zaoxn author: nan title: Publication only date: 2006-03-08 words: 51926.0 sentences: 2983.0 pages: flesch: 53.0 cache: ./cache/cord-014976-546zaoxn.txt txt: ./txt/cord-014976-546zaoxn.txt summary: In order to evaluate if malignant and non malignant hematological diseases quantitatively and qualitatively affect BM derived MSCs, bone marrow from children with acute lymphoblastic leukemia (ALL diagnosis n=9, different phases of treatment n=29, end of therapy n=10), idiopathic thrombocytopenic purpura (n=16), autoimmune neutropenia (n=12) and control patients (solid tumors without BM involvement, n=30) was harvested and the mononuclear cell (MNC) fraction isolated. Case: In our hospital a total of 3 patients with relapsed Hodgkin''s disease underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) from an HLA-identical sibling. We report a case of a young male patient of 19 years old with aggressive MS who was treated with a high-dose immunosuppressive regimen (HDIS) using myeloablation followed by autologous blood stem cell transplantation (ASCT) that has induced a dramatic and long-lasting remission of the disease. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092326/ doi: 10.1038/sj.bmt.1705327 id: cord-015021-pol2qm74 author: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 words: 162327.0 sentences: 9379.0 pages: flesch: 50.0 cache: ./cache/cord-015021-pol2qm74.txt txt: ./txt/cord-015021-pol2qm74.txt summary: It is our current understanding that LPS is responsible for many of the pathophysiological events observed during gramnegative infections and that one of the major mechanisms leading to shock and death is the LPS-induced activation of macrophages resulting in the production and release of lipid and peptide mediators, among which tumor necrosis factor seems to be the most important. However plasma IL-6 estimation revealed a statistically significant reduction at 6 hours in tanrine-treated animals compared to glycino and TW controls ( Objective: To evaluate the effects of allogeneic blood transfusion, thermal injury and bacterial garage on interteukin 4 (IL-4), tumor necrosis factor alpha (TNF) production and host mortality and to study if the administration of thymopentth (THY) could affect these events. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095072/ doi: 10.1007/bf02258437 id: cord-015024-2xzc0uc5 author: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 words: 84393.0 sentences: 5234.0 pages: flesch: 52.0 cache: ./cache/cord-015024-2xzc0uc5.txt txt: ./txt/cord-015024-2xzc0uc5.txt summary: We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095088/ doi: 10.1007/s00134-010-2001-7 id: cord-015090-n6f4xupw author: nan title: PS 339-563 date: 2005-09-10 words: 26280.0 sentences: 1560.0 pages: flesch: 53.0 cache: ./cache/cord-015090-n6f4xupw.txt txt: ./txt/cord-015090-n6f4xupw.txt summary: We designed this study to examine the effects of fiberoptic bronchoscopy (FOB) with and without BAL on body temperature, systemic arterial pressure, heart rate and supportive therapies requirements in mechanically ventilated patients. Clinical characteristics (Glasgow scale, heart rate, systolic blood pressure), cardiac enzymes (troponin I, total serum creatine kinase and myocardial isoenzyme, myoglobin), ECG changes (ST-T changes, prolonged QT and corrected QT intervals), echocardiographic assessment of cardiac function (left ventricular ejection fraction, hypokinesia) were studied on the day of the admission. It is a prospective study performed during 12 months of the patients with brain trauma admitted in a 24-beds medical-surgical ICU of a 650-beds university hospital. This prospective observational study included 200 adult patients admitted to a 31-bed university hospital medical-surgical ICU during a 3-month period. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095344/ doi: 10.1007/s00134-005-2780-4 id: cord-015126-cyhcbk1j author: nan title: PS 0036-0344 date: 2007-08-25 words: 59175.0 sentences: 3672.0 pages: flesch: 54.0 cache: ./cache/cord-015126-cyhcbk1j.txt txt: ./txt/cord-015126-cyhcbk1j.txt summary: We compared them with ≥70 years old and an ICU stay < 30 days patients, the differences in ICU mortality, Apache II, age, gender and the necessity for renal replacement therapy (RRT) were not significant (see table) . The patients with mild form of acute pancreatitis had low mortality rate (similar to general ward population) despite positive ICU admission criteria in our case series with fifty per cent development of severe form with organ dysfunction/failure later on. Collected data:Demographics,Management prior and during ICU hospitalization (sedation, catecolamin drug use, blood product transfusion, intra-cranial pressure monitoring, neurosurgical emergency surgery etc.),CT-Scan results, Daily worst Glasgow coma scale, admission Simplified Acute Physiology Score II. This prospective interventional study performed in a surgical Intensive Care Unit of a tertiary University Hospital included 35 (21 males) mechanically ventilated and sedated patients with acute cardiovascular failure requiring cardiac output measurement (transpulmonary thermodilution technique)and a fluid challenge. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095535/ doi: 10.1007/s00134-007-0820-y id: cord-015369-72cjogxz author: nan title: 50th Annual Meeting of the Austrian Society of Surgery. Vienna, June 18–20, 2009. Guest Editors: Albert Tuchmann, Erhard Schwanzer, Benedikt Walzel date: 2009 words: 71071.0 sentences: 7094.0 pages: flesch: 50.0 cache: ./cache/cord-015369-72cjogxz.txt txt: ./txt/cord-015369-72cjogxz.txt summary: Bei 2 Patienten wurde wegen eines Rezidivs eine neuerliche RFT mit liver packing notwendig, 5 Patienten wurden ohne Packing ein zweites mal abladiert und ein Patient unterzog sich einer linksseitigen Hemihepatektomie nach rechtsseitiger Ablation. Das laparoskopische Liver Packing ermöglicht eine ablative Therapie der Leber in Patienten, die mit den herkömmlichen Möglichkeiten nicht lokal therapierbar sind. Zusammenfassend lässt sich anhand der hier vorliegenden Studie zeigen, dass die Therapie von VSM mittels ELT mit 1470-nm-Diodenlaser und Radialfaser eine sowohl minimalinvasive als auch sichere und effiziente Therapieoption darstellt und eine hohe frühzeitige Erfolgsrate bei niedrigem Schmerzniveau aufweist.In weiteren Studien muss geprueft werden, ob aehnlich gute Resultate auch bei weiterer Absenkung des Energienivaus zu erreichen sind. Patients who underwent R0 resection for colon and rectal cancer during the period 1995-2000 showed a significantly improved 5-year survival rate compared to those operated on between 1991 and 1995. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103189/ doi: 10.1007/s10353-009-0461-1 id: cord-015389-vwgai4k9 author: nan title: Publication only date: 2009-03-25 words: 23868.0 sentences: 1465.0 pages: flesch: 57.0 cache: ./cache/cord-015389-vwgai4k9.txt txt: ./txt/cord-015389-vwgai4k9.txt summary: This study evaluates the safety of this approach, in terms of infusion-related toxicity and hematopoietic reconstitution, in 385 consecutive autologous transplantations performed from 4/97 to 9/08 in 348 patients (median age 46; underlying disease: lymphoma in 178, myeloma in 131, acute leukaemia in 17, breast cancer in 22). Patients and methods: Eight pts after allogeneic hematopoetic stem cell transplantation (HSCT) underwent MSCs infusions (median age of pts was 11 years, male/female: 6/2) between 2006 and 2009. Akiyama Tokyo Metropolitan Komagome Hospital (Tokyo, JP) Acute graft-versus-host disease (GVHD) is one of the major factors that have infl uence on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). Material and methods: during a 8 years period we have performed 144 stem cells transplantation in 134 patients with different hematological malignancies(AML: 74; ALL: 6; CML: 7; CLL: 1, NHL: 13; Hodgkin Diseases: 16; Multiple myelomas: 24; Aplastic anaemia: 1;Myelofi brosis:1 Ewing Sarcoma: 1; Male:78 Female 66. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104434/ doi: 10.1038/bmt.2009.50 id: cord-022659-chwk2bs4 author: nan title: Abstracts: Poster session date: 2004-10-08 words: 49153.0 sentences: 2598.0 pages: flesch: 49.0 cache: ./cache/cord-022659-chwk2bs4.txt txt: ./txt/cord-022659-chwk2bs4.txt summary: We investigated the usefulness of informant-based data in Alzheimer''s disease (AD) by comparing caregivers'' subjective evaluations of 83 probable A D patients'' performance on an abbreviated version of the Memory Self-Report Questionnaire to objective evaluations derived from an extensive battery of neuropsychological tests and to clinicians'' evaluations. Compared with 89 subjects (mean age 75.2 yr; 34 men, 55 women) with dementia of the Alzheimer type (DAT), there were no significant group differences for comparable Clinical Dementia Rating stages of dementia for measures of language, Activities of Daily Living, or general cognition. The mean age at onset did not differ significantly between handedness groups (F [ l,lOO] = .82), but the mean duration of symptoms ( Alterations in the optical properties of brain can be used to detect pathological changes in patients with Alzheimer''s disease (AD). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159508/ doi: 10.1002/ana.410320224 id: cord-023017-k6edtg58 author: nan title: AASLD Abstracts (pp. 282A–382A) date: 2006-02-10 words: 65796.0 sentences: 3553.0 pages: flesch: 51.0 cache: ./cache/cord-023017-k6edtg58.txt txt: ./txt/cord-023017-k6edtg58.txt summary: 14/55 (25%) patients in AC who did not discontinue by week 24 received ribavirin dose reduction in comparison to 31/108 ( The clinical outcome in response to combination therapy for treatment of chronic hepatitis C virus (HCV) infection appears to be different for Caucasian versus African American patients. Over the period of combination therapy, most patients in which serum virus titers were reduced to non detectable levels had significant increases in T cell responses to HCV proteins. CHRONIC Background: Recent large prospective trials demonstrated that the combination therapy of interferon (1FN)-alphalribavirin significantly increased the ratio of a sustained virological response in patients with chronic hepatitis C in comparison with IFN monotherapy, especially in patients with high HCV-RNA titer and genotype lb. Results: Patients with chronic HCV infection showed higher MxA gene expression levels than healthy controls, indicating that hepatitis C virus induces IFN production. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165819/ doi: 10.1002/hep.1840380505 id: cord-023095-4dannjjm author: nan title: Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011 date: 2011-05-03 words: 134226.0 sentences: 6834.0 pages: flesch: 51.0 cache: ./cache/cord-023095-4dannjjm.txt txt: ./txt/cord-023095-4dannjjm.txt summary: The purpose of this study was to determine the short-term effects of ivabradine on heart rate (HR), blood pressure, left ventricular (LV) systolic and diastolic function, left atrial (LA) performance, and clinical tolerance in healthy cats after repeated oral doses. The goal of this study was to investigate the relationship between heart rate and ECG time intervals to body mass in apparently healthy horses and ponies and to calculate normal ranges for different weight groups. This study aimed to investigate the prevalence of hypercoagulability in PLN dogs based on thromboelastography (TEG), and to determine whether hypercoagulability in these patients could be predicted by clinical assessments that identify systemic hypertension (systolic blood pressure 4 160 mmHg), hypoalbuminemia (serum albumin o 2.7 mg/dl), antithrombin activity (o 70%), and degree of proteinuria (urine protein:creatinine ratio [UPC] ! abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166756/ doi: 10.1111/j.1939-1676.2011.0726.x id: cord-023100-0pqnsiid author: nan title: Abstract date: 2008-04-10 words: 244.0 sentences: 20.0 pages: flesch: 65.0 cache: ./cache/cord-023100-0pqnsiid.txt txt: ./txt/cord-023100-0pqnsiid.txt summary: key: cord-023100-0pqnsiid authors: nan cord_uid: 0pqnsiid nan The dogs had mild diarrhoea from three to 11 days after inoculation, approximately at the same time as the virus was excreted in the faeces. Virus could be isolated from the tonsils on day 3, and then from small and large intestinal tissues up to 14 days after inoculation; it was also isolated from liver and lung tissue. Virus neutralising antibody was first detected on day 10. Specific anti-ccv IgM was first detected in plasma three days after inoculation and IgG on days 4 to 7. Small amounts of anti-ccv IgG, IgM and IgA were detected in duodenal secretions, but none in bile. Chronic relapsing (dysimmune) polyneuropathy: diagnosis and treatment Chronic relapsing polyradiculoneuritis in a cat Peripheral neuropathy in cats with inherited primary hyperchylomicronaemia The authors wish to thank Karen Wadewell and Denise Wigney for expert technical assistance, and Dr A. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166814/ doi: 10.1111/j.1748-5827.1991.tb00876.x id: cord-335975-m6lkrehi author: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 words: 89374.0 sentences: 5327.0 pages: flesch: 52.0 cache: ./cache/cord-335975-m6lkrehi.txt txt: ./txt/cord-335975-m6lkrehi.txt summary: A qSOFA score relying on 3 simple clinical criteria (respiratory rate, mental status and systolic blood pressure) has been proposed to better identify septic patients with associated higher mortality outside the intensive care unit (Seymour CW et al., JAMA 2016) . We propose to determine whether the arterial oxygen pressure (PaO2) at intensive care unit (ICU) admission affects mortality at day 28 (D28) in patients with septic shock subjected to mechanical out-of-hospital ventilation. Conclusion: In this study, we report a significant association between hyperoxemia at ICU admission and mortality at D28 in patients with septic shock subjected to pre-hospital invasive mechanical ventilation. The aim of this study was to describe outcome of pediatric patient with hematologic disease hospitalized in our intensive care unit for respiratory failure and to investigate the clinical variables associated with mortality. abstract: nan url: https://doi.org/10.1186/s13613-017-0345-7 doi: 10.1186/s13613-017-0345-7 id: cord-341063-3rqnu5bu author: nan title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 words: 98602.0 sentences: 6494.0 pages: flesch: 52.0 cache: ./cache/cord-341063-3rqnu5bu.txt txt: ./txt/cord-341063-3rqnu5bu.txt summary: Procacitonin (PCT) emerges as a possible predictive tool in cardiothoracic intensive care unit (CTICU).We aim at testing the predictive power of PCT for early morbidity, prolonged ventilation, ICU and hospital stay, in patients developing early fever after cardiac surgery Methods: A retrospective descriptive study done in tertiary cardiac center, enrolling patients who stayed for more than 24 hours post-operatively in the CTICU Risk stratification included additive Euro score and PCT immunoluminometricaly prior to surgery and every 48 hours in response to onset of fever. Prognostic accuracy of quick sequential organ failure assessment (qSOFA) score for mortality: systematic review and meta-analysis Introduction: The purpose of this study was to summarize the evidence assessing the qSOFA [1] , calculated in admission of the patient in emergency department (ED) or intensive care unit (ICU), as a predictor of mortality. abstract: nan url: https://doi.org/10.1186/s13054-018-1973-5 doi: 10.1186/s13054-018-1973-5 id: cord-355038-o2hr5mox author: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32048060/ doi: 10.1186/s13613-020-0623-7 id: cord-317347-by8albr9 author: van Ginkel, Frederik W. title: Age-dependent immune responses and immune protection after avian coronavirus vaccination date: 2015-05-28 words: 5792.0 sentences: 288.0 pages: flesch: 53.0 cache: ./cache/cord-317347-by8albr9.txt txt: ./txt/cord-317347-by8albr9.txt summary: The delayed and/or lower antibody response combined with lower IgG avidity indices coincided with increased tracheal inflammation and depletion of tracheal epithelia cells and goblet cells upon IBV field strain challenge. Therefore, the ability of SPF chickens of different age to induce an IBV-specific antibody response and protect against challenge with an IBV field strain was measured. In order to measure IgG (IgY), IgA and IgM antibody levels in plasma and tears of chicken, an IBV-specific enzyme-linked immunosorbent assay (ELISA) was developed as previously described [20] . These data are consistent with a delay in the IgA plasma response to IBV in birds vaccinated at a younger age and a non-significant decline in mean IgA titers in the 1-day-old group. This would be consistent with a drop of presumably natural maternal IBV-specific IgM antibodies in these SPF chickens in the day 7 control age group. abstract: Infectious bronchitis virus (IBV) is an endemic disease of chickens and a major contributor to economic losses for the poultry industry despite vaccination. Recent observations indicated that chicks may have an immature immune system immediately after hatching when vaccinated for IBV. Therefore we hypothesized that early IBV vaccination will generate an immature, poorly protective IBV-specific immune response contributing to immune escape and persistence of IBV. To test this hypothesis the IBV-specific immune response and immune protection were measured in chicks vaccinated at different ages. This demonstrated a delayed production of IgG and IgA plasma antibodies in the 1, 7 and 14-day-old vaccination groups and also lower IgA antibody levels were observed in plasma of the 1-day-old group. Similar observations were made for antibodies in tears. In addition, IgG antibodies from the 1-day-old group had lower avidity indices than day 28 vaccinated birds. The delayed and/or lower antibody response combined with lower IgG avidity indices coincided with increased tracheal inflammation and depletion of tracheal epithelia cells and goblet cells upon IBV field strain challenge. The lack of vaccine-mediated protection was most pronounced in the 1-day-old vaccination group and to a lesser extent the 7-day-old group, while the 14-day-old and older chickens were protected. These data strongly support IBV vaccination after day 7 post hatch. url: https://api.elsevier.com/content/article/pii/S0264410X1500479X doi: 10.1016/j.vaccine.2015.04.026 id: cord-001192-zbogocki author: van Meer, Maurits PA title: Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report date: 2014-01-30 words: 4217.0 sentences: 229.0 pages: flesch: 47.0 cache: ./cache/cord-001192-zbogocki.txt txt: ./txt/cord-001192-zbogocki.txt summary: A 23-year-old healthy male volunteer took part in a clinical trial in which the volunteer took chloroquine chemoprophylaxis and received three intradermal doses at four-week intervals of aseptic, purified Plasmodium falciparum sporozoites to induce protective immunity against malaria. Here, a very probable case of acute myocarditis is described in a volunteer who had taken chloroquine chemoprophylaxis, was inoculated three times at fourweek intervals with PfSPZ Challenge, received six travelrelated routine vaccines after this immunization procedure, had CHMI by the bites of five PfSPZ-infected mosquitoes 8.5 weeks after the last dose of PfSPZ Challenge and 4.5 weeks after the last dose of chloroquine, had a sore throat on day 9 after CHMI, developed P. Fatal myocarditis in course of Plasmodium falciparum infection: case report and review of cardiac complications in malaria Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report abstract: A 23-year-old healthy male volunteer took part in a clinical trial in which the volunteer took chloroquine chemoprophylaxis and received three intradermal doses at four-week intervals of aseptic, purified Plasmodium falciparum sporozoites to induce protective immunity against malaria. Fifty-nine days after the last administration of sporozoites and 32 days after the last dose of chloroquine the volunteer underwent controlled human malaria infection (CHMI) by the bites of five P. falciparum-infected mosquitoes. Eleven days post-CHMI a thick blood smear was positive (6 P. falciparum/μL blood) and treatment was initiated with atovaquone/proguanil (Malarone®). On the second day of treatment, day 12 post-CHMI, troponin T, a marker for cardiac tissue damage, began to rise above normal, and reached a maximum of 1,115 ng/L (upper range of normal = 14 ng/L) on day 16 post-CHMI. The volunteer had one ~20 minute episode of retrosternal chest pain and heavy feeling in his left arm on day 14 post-CHMI. ECG at the time revealed minor repolarization disturbances, and cardiac MRI demonstrated focal areas of subepicardial and midwall delayed enhancement of the left ventricle with some oedema and hypokinesia. A diagnosis of myocarditis was made. Troponin T levels were normal within 16 days and the volunteer recovered without clinical sequelae. Follow-up cardiac MRI at almost five months showed normal function of both ventricles and disappearance of oedema. Delayed enhancement of subepicardial and midwall regions decreased, but was still present. With the exception of a throat swab that was positive for rhinovirus on day 14 post-CHMI, no other tests for potential aetiologies of the myocarditis were positive. A number of possible aetiological factors may explain or have contributed to this case of myocarditis including, i) P. falciparum infection, ii) rhinovirus infection, iii) unidentified pathogens, iv) hyper-immunization (the volunteer received six travel vaccines between the last immunization and the CHMI), v) atovaquone/proguanil treatment, or vi) a combination of these factors. Definitive aetiology and pathophysiological mechanism for the myocarditis have not been established. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909449/ doi: 10.1186/1475-2875-13-38 ==== make-pages.sh questions [ERIC WAS HERE] ==== make-pages.sh search /data-disk/reader-compute/reader-cord/bin/make-pages.sh: line 77: /data-disk/reader-compute/reader-cord/tmp/search.htm: No such file or directory Traceback (most recent call last): File "/data-disk/reader-compute/reader-cord/bin/tsv2htm-search.py", line 51, in with open( TEMPLATE, 'r' ) as handle : htm = handle.read() FileNotFoundError: [Errno 2] No such file or directory: '/data-disk/reader-compute/reader-cord/tmp/search.htm' ==== make-pages.sh topic modeling corpus Zipping study carrel