Summary of your 'study carrel' ============================== This is a summary of your Distant Reader 'study carrel'. The Distant Reader harvested & cached your content into a collection/corpus. It then applied sets of natural language processing and text mining against the collection. The results of this process was reduced to a database file -- a 'study carrel'. The study carrel can then be queried, thus bringing light specific characteristics for your collection. These characteristics can help you summarize the collection as well as enumerate things you might want to investigate more closely. This report is a terse narrative report, and when processing is complete you will be linked to a more complete narrative report. Eric Lease Morgan Number of items in the collection; 'How big is my corpus?' ---------------------------------------------------------- 134 Average length of all items measured in words; "More or less, how big is each item?" ------------------------------------------------------------------------------------ 29326 Average readability score of all items (0 = difficult; 100 = easy) ------------------------------------------------------------------ 51 Top 50 statistically significant keywords; "What is my collection about?" ------------------------------------------------------------------------- 127 day 49 patient 26 study 21 ICU 20 group 19 result 19 cell 18 method 16 Care 15 Hospital 14 conclusion 14 ARDS 13 University 12 January 11 treatment 11 mortality 10 high 10 Intensive 10 CSF 10 COVID-19 9 TBI 9 SARS 9 Fig 8 sofa 8 VAP 8 ICP 8 APACHE 7 introduction 7 figure 7 case 7 blood 7 PCR 7 IQR 7 HSCT 7 GCS 7 ECMO 7 Day 6 level 6 increase 6 disease 6 animal 6 MRI 6 HLA 6 CMV 6 AML 6 AKI 5 peep 5 outcome 5 infection 5 dog Top 50 lemmatized nouns; "What is discussed?" --------------------------------------------- 49742 patient 40761 % 17039 day 14023 study 12800 cell 12580 group 8901 result 8311 treatment 8215 p 8023 blood 7692 time 7615 case 7081 disease 6977 year 6501 infection 6472 level 6419 method 5713 outcome 5428 mortality 5296 analysis 5294 datum 5144 rate 4997 age 4981 risk 4736 therapy 4700 conclusion 4626 effect 4506 month 4469 donor 4458 care 4146 hospital 3988 factor 3874 dose 3740 response 3558 score 3536 control 3430 period 3427 difference 3423 complication 3306 n 3293 use 3233 injury 3209 surgery 3209 number 3191 hour 3164 transplantation 3124 sample 3123 value 3116 admission 3109 diagnosis Top 50 proper nouns; "What are the names of persons or places?" -------------------------------------------------------------- 6236 ICU 3281 HSCT 2938 mg 1813 GVHD 1653 II 1528 kg 1511 CI 1425 CT 1388 . 1342 T 1295 C 1176 Hospital 1156 CMV 1118 University 1114 ± 1088 CSF 1069 IV 1055 al 1018 ARDS 1011 SCT 988 HLA 969 Care 964 A 954 L 949 OS 911 et 901 G 900 TBI 888 CD34 871 LPS 858 January 838 B 831 ICH 823 RBC 821 AML 791 TNF 791 PCR 777 Group 774 der 755 Background 730 ICP 730 HCV 725 Fig 721 IL-6 674 M 658 ATG 656 GvHD 651 Study 601 MRI 598 SAH Top 50 personal pronouns nouns; "To whom are things referred?" ------------------------------------------------------------- 13798 we 5369 it 1832 they 1552 i 1184 them 1058 he 738 she 274 us 123 itself 119 one 81 you 80 themselves 48 me 37 him 25 her 20 himself 11 herself 9 s 9 myself 9 iicas 8 mrs 8 mg 6 em 5 itma 5 cha 4 ourselves 4 ours 4 oneself 2 theirs 2 thee 2 rrt 2 pm.sec- 2 igg4 1 ≥65 1 αat 1 yourself 1 wi~ 1 tv/ 1 tsd 1 trs\3 1 tnf~ 1 tnfrt 1 tdcs 1 ta 1 t 1 srbcs 1 slr 1 sglt2-inhibitors 1 s382 1 rhll-4 Top 50 lemmatized verbs; "What do things do?" --------------------------------------------- 148773 be 21242 have 12059 use 6865 include 6081 show 5740 perform 5570 compare 5540 associate 5389 increase 5289 receive 5019 follow 4639 do 3535 treat 3446 evaluate 3407 develop 3200 find 3090 report 3082 observe 3037 reduce 2954 base 2876 undergo 2864 identify 2822 require 2709 assess 2672 determine 2654 occur 2618 present 2517 measure 2480 relate 2390 improve 2370 decrease 2338 die 2206 suggest 2201 remain 2186 induce 2109 consider 2094 admit 2061 provide 2015 analyze 1993 collect 1943 cause 1922 obtain 1848 demonstrate 1761 give 1740 study 1718 result 1716 define 1689 detect 1672 need 1652 describe Top 50 lemmatized adjectives and adverbs; "How are things described?" --------------------------------------------------------------------- 11232 not 9979 - 9054 high 6368 clinical 5232 acute 5019 low 4820 more 4631 significant 4457 also 4114 other 4066 first 4018 severe 3904 only 3899 median 3851 well 3846 significantly 3540 however 3359 respectively 3353 non 3173 most 3064 early 2944 respiratory 2818 mean 2522 positive 2453 different 2417 such 2209 normal 2202 surgical 2193 cardiac 2186 long 2184 as 2100 old 2061 post 2038 medical 1967 total 1924 common 1890 further 1864 chronic 1824 intensive 1823 large 1806 overall 1804 negative 1794 specific 1792 primary 1781 patient 1775 good 1759 less 1741 anti 1739 septic 1715 pulmonary Top 50 lemmatized superlative adjectives; "How are things described to the extreme?" ------------------------------------------------------------------------- 725 most 597 least 540 good 424 high 409 Most 209 low 105 large 77 great 68 bad 55 late 39 early 39 common 37 strong 29 close 21 long 17 old 16 young 15 small 14 big 9 near 8 short 8 p=0.016 6 fast 6 easy 5 deep 5 -t 4 safe 4 poor 3 weak 3 steep 3 severe 3 -ch 2 ⁄ 2 wiederhergestellt 2 wide 2 strict 2 slow 2 simple 2 rare 2 postt 2 new 2 fresh 2 broad 2 Least 2 -promptly 1 ~trointesfimd 1 ~I 1 wealthy 1 value(% 1 submucosa Top 50 lemmatized superlative adverbs; "How do things do to the extreme?" ------------------------------------------------------------------------ 2448 most 486 least 60 well 8 highest 3 fast 2 long 2 hard 1 ® 1 worst 1 themost 1 strongest 1 shortest 1 lowest 1 freshest 1 farthest 1 early 1 -tion 1 -chest 1 -0.2881 Top 50 Internet domains; "What Webbed places are alluded to in this corpus?" ---------------------------------------------------------------------------- 52 doi.org 9 links.lww.com 6 ccforum.com 5 clinicaltrials.gov 5 bit.ly 3 dx.doi.org 2 www.fda.gov 1 www.who.int 1 www.tinnitus-liga.de 1 www.statista.com 1 www.siopen-r-net.org 1 www.rilintech.comt 1 www.real-score.org 1 www.preprints.org 1 www.nytimes.com 1 www.meteo-bretagne.fr 1 www.medresman.org 1 www.medresman 1 www.mdpi.com 1 www.isbtweb.org 1 www.healthdata.org 1 www.gnomixx.com 1 www.folkhalsomyndigheten 1 www.farad.org> 1 www.emergency.spb.ru 1 www.ebmt.org 1 www.covid19treatmentguidelines.nih.gov 1 www.covid19-druginteractions.org 1 www.colorectaleducation.com 1 www.clinicaltrialsregister.eu 1 www.clinicaltrials.gov 1 www.cebm.net 1 www.bundles.com.br 1 www.rproject.org 1 www 1 qmrawiki.org 1 portal 1 ourworldindata.org 1 osf.io 1 orcid.org 1 jsp.tm.nagasaki-u.ac.jp 1 journals.lww.com 1 iddynamics.jhsph.edu 1 github.com 1 creativecommons.org 1 creat 1 bit 1 amstar.ca 1 clinicaltrials.gov Top 50 URLs; "What is hyperlinked from this corpus?" ---------------------------------------------------- 13 http://doi.org/10.1101/2020.10.05.20206870 12 http://doi.org/10.1101/2020.10.03.20206359 6 http://doi.org/10.1101/2020.10.02.20202614 6 http://doi.org/10.1101/2020.09 6 http://ccforum.com/supplements/17/S2 3 http://doi.org/10.1101/2020.09.26.20202457 3 http://doi.org/10.1101/2020.07.17.20156539 3 http://doi.org/10.1101 3 http://doi.org/10 2 http://www.fda.gov/media/141477/download 2 http://links.lww.com/CCX/A203 2 http://links.lww.com/CCX/A194 2 http://clinicaltrials.gov/ 1 http://www.who.int/emergencies/diseases/novel-coronavirus-2019 1 http://www.tinnitus-liga.de 1 http://www.statista.com/topics/5994/the-coronavirus-disease-covid-19-outbreak/ 1 http://www.siopen-r-net.org 1 http://www.rilintech.comt 1 http://www.real-score.org 1 http://www.preprints.org/manuscript/202004.0345/v1 1 http://www.nytimes.com/interactive/2020/science/coronavirusvaccine-tracker.html 1 http://www.meteo-bretagne.fr/normalesclimatiques-Rennes 1 http://www.medresman.org 1 http://www.medresman 1 http://www.mdpi.com/2077-0383/9/2/601/s1 1 http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-bloodgroup-terminology/ 1 http://www.healthdata.org/covid 1 http://www.gnomixx.com/ 1 http://www.folkhalsomyndigheten 1 http://www.farad.org> 1 http://www.emergency.spb.ru/ 1 http://www.ebmt.org/Contents/About-EBMT/Who-We-Are/ScientificCouncil/Documents/IDWPdefiniti 1 http://www.covid19treatmentguidelines.nih.gov/ 1 http://www.covid19-druginteractions.org/ 1 http://www.colorectaleducation.com/ 1 http://www.clinicaltrialsregister.eu/ctr-search/search?query=ALXN1210-COV-305 1 http://www.clinicaltrials.gov/ct2/show/NCT01560182? 1 http://www.cebm.net 1 http://www.bundles.com.br 1 http://www.Rproject.org/ 1 http://www 1 http://qmrawiki.org/content/recommendedbest-fit-parameters 1 http://portal 1 http://ourworldindata.org/coronavirus-source-data 1 http://osf.io/cm4f8/ 1 http://orcid.org/0000-0001-7664-9568 1 http://links.lww.com/SHK/B52 1 http://links.lww.com/CCX/A202 1 http://links.lww.com/CCX/A201 1 http://links.lww.com/CCX/A199 Top 50 email addresses; "Who are you gonna call?" ------------------------------------------------- 2 yacine001@yahoo.fr 2 ovidstudie@usz.ch 2 oussamajaoued@gmail.com 2 benhamzasabah5@gmail.com 1 webmaster@eubs.org 1 sophie.jacquier@chr-orleans.fr 1 samia.ayed@yahoo.fr 1 sadatsouhila@hotmail.fr 1 paul.jaubert@gmail.com 1 painvinbe@gmail.com 1 nicolas.garbez@umontpellier.fr 1 nabilghomari@hotmail.fr 1 mel.fromentin@wanadoo.fr 1 mariem241090@gmail.com 1 marielemerle@yahoo.fr 1 lisaleon1307@gmail.com 1 lea.savary@hotmail.com 1 khaoula87@hotmail.fr 1 kais.regaieg@gmail.com 1 julien.goutay@gmail.com 1 journals.permissions@oupjournals.org 1 jean-luc.baudel@aphp.fr 1 jaypatwardhan3@gmail.com 1 jabirachid@gmail.com 1 hgheerbrant@chu-grenoble.fr 1 guillaume.geri@aphp.fr 1 geoffroyhariri@hotmail.com 1 gautier.nitel@gmail.com 1 fanny.ardisson@gmail.com 1 erwan.begot@chu-bordeaux.fr 1 dr.amira.jamoussi@gmail.com 1 def2004@cumc.columbia.edu 1 cm3297@cumc.columbia.edu 1 claravigneron@hotmail.fr 1 chiche@aphp.fr 1 cguetteche@gmail.com 1 alex.lepage-farrell@umontreal.ca 1 adnanejanati@gmail.com 1 picu@its.mew.edu 1 nicu-net@u.washington.edu 1 -zakaria.riad@icloud.com 1 -titeca.dimitri@chu-amiens.fr 1 -tardif.elsa@gmail.com 1 -sahar.habacha@gmail.com 1 -mickaelandais@gmail.com 1 -maud.loiselle@outlook.fr 1 -m.goulmane@hotmail.com 1 -laurent.brisard@chu-nantes.fr 1 -jonathan.dugernier@uclouvain.be 1 -gioia.gastaldi@chu-rouen.fr Top 50 positive assertions; "What sentences are in the shape of noun-verb-noun?" ------------------------------------------------------------------------------- 77 patients did not 65 patients are alive 59 % were male 53 levels were significantly 43 patients were male 38 patients were not 35 data are available 31 patient did not 31 patients were alive 29 mortality was higher 29 patients undergoing cardiac 27 groups were similar 27 patients undergoing hsct 27 patients were randomly 26 % were female 24 groups were comparable 24 mortality was significantly 22 patients do not 21 group was significantly 21 levels were higher 21 patients undergoing elective 20 patients received myeloablative 19 groups did not 19 studies are necessary 19 study did not 18 levels were lower 18 levels were not 18 patient was not 18 patients had significantly 18 patients were prospectively 18 rate was significantly 17 % were men 17 patients developed acute 17 patients had acute 17 patients had at 17 patients were eligible 17 treatment is not 16 patients had more 15 disease is not 15 patients were also 14 % did not 14 analysis did not 14 group did not 14 patients had grade 14 patients had normal 14 patients is not 14 treatment related mortality 13 % were males 13 case report form 13 data were retrospectively Top 50 negative assertions; "What sentences are in the shape of noun-verb-no|not-noun?" --------------------------------------------------------------------------------------- 6 results were not statistically 5 patients is not well 4 groups was not significantly 4 levels were not significantly 4 treatment had no effect 3 % had no effect 3 mortality were not significantly 3 rate was not different 3 rates were not statistically 2 analysis showed no difference 2 cases had no complications 2 cells were not statistically 2 disease is not usually 2 effect was not significant 2 groups was not statistically 2 groups were not significantly 2 groups were not statistically 2 levels were not different 2 months was not significantly 2 mortality did not significantly 2 mortality was not different 2 patient had no significant 2 patient was not statistically 2 patients had no response 2 patients had no significant 2 patients were not evaluable 2 patients were not subsequently 2 rate were not different 2 rates were not different 2 results showed no significant 2 results were not available 2 study found no significant 2 time was not significantly 2 treatment is not necessary 1 % had no change 1 % had no clinical 1 % had no risk 1 % has no negative 1 % having no experience 1 % is not much 1 % received no respiratory 1 % were not aware 1 % were not comfortable 1 % were not conscious 1 age showed no significant 1 age was not singly 1 analysis does not simply 1 analysis is not exhaustive 1 analysis showed no differences 1 analysis showed no evidence A rudimentary bibliography -------------------------- id = cord-295703-no45mgyd author = ALTAY, O. title = Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 date = 2020-10-05 keywords = CMCS; COVID-19; day; patient summary = Combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and L-carnitine tartrate is being studied for the treatment of patients with COVID-19. CONCLUSIONS In patients with mild-to-moderate COVID-19, CMCS resulted in a significant reduction in recovery time and liver enzymes associated with hepatic function compared to placebo. Recently, we performed integrative analysis of multi-omics data on different metabolic conditions and found that combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and Lcarnitine tartrate may be used for treatment of the patients with non-alcoholic fatty liver diseases (11, 12) . In this randomized, open-label, placebo-controlled, phase 2 trial involving ambulatory COVID-19 patients, we found that the combination of CMCS and hydroxychloroquine significantly reduced the average recovery time compared with hydroxychloroquine and placebo (6.6 days vs 9.3 days, respectively). doi = 10.1101/2020.10.02.20202614 id = cord-330414-yh58ya39 author = Agarwal, Deepak K. title = Catheter Removal on the Same Day of Holmium Laser Enucleation of the Prostate: Outcomes of a Pilot Study date = 2020-10-10 keywords = catheter; day summary = title: Catheter Removal on the Same Day of Holmium Laser Enucleation of the Prostate: Outcomes of a Pilot Study OBJECTIVES: To determine if same day catheter removal is feasible in select population after holmium laser enucleation of the prostate (HoLEP). For patients who successfully passed their voiding trial, the median time from the end of the procedure to hospital discharge was 2.6 hours (IQR (2.1-2.9) and from the end of the HoLEP to catheter removal was 4.9 hours (IQR 3.5-6.0). Patients who were not offered same day catheter removal were those with prostate volumes >250 ml on preoperative imaging study (all were required to have imaging to be considered). The rate of passage of voiding trial on the same day as surgery is also similar to recent studies, 11, 12 demonstrating there is no added risk to patient of catheter reinsertion after BPH procedures. doi = 10.1016/j.urology.2020.09.038 id = cord-343789-6tq0kcfd author = Al-Tawfiq, Jaffar A. title = Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study date = 2014-01-06 keywords = MERS; day summary = title: Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study RESULTS: All patients were critically ill with acute respiratory distress syndrome treated with adjunctive corticosteroids and were on mechanical ventilation at the time of initiation of therapy. Since the discovery of Middle East respiratory syndrome coronavirus (MERS-CoV), the virus has caused 163 cases of disease, with a fatality rate of 43-50%. In a recent review, based on therapies used for the related severe acute respiratory syndrome (SARS) coronavirus, the possible use of interferon and ribavirin was considered as a therapeutic option. 8 The purpose of this study was to describe the outcome of the use of a combination of interferon-a2b and ribavirin in the management of five patients with MERS-CoV infections. 20 In a rhesus macaque model of MERS-CoV infection, the combination of interferon-a2b and ribavirin therapy was effective in limiting the disease and resulted in very mild radiographic evidence of pneumonia. doi = 10.1016/j.ijid.2013.12.003 id = cord-163587-zjnr7vwm author = Altmejd, Adam title = Nowcasting Covid-19 statistics reported withdelay: a case-study of Sweden date = 2020-06-11 keywords = day; death; report summary = In this paper we describe a statistical methodology for nowcasting the epidemic statistics, such as hospitalizations or deaths, and their degrees of uncertainty, based on the daily reported event frequency and the observed distribution pattern of reporting delays. We propose to use the removal method, developed in animal management (Pollock, 1991) , to present an estimate of the actual frequencies at a given day and their uncertainty. To account for this, we allow the estimated proportions of daily reported cases to follow a probability distribution taking into consideration what type of day it is. We propose a Bayesian version of the removal model that assumes an overdispersed binomial distribution for the daily observations of deaths in Sweden in COVID-19. Another limitation is that the model assumes that the number of new reported deaths for a given day cannot be negative, which is not actually true, due to miscount or misclassification of days. doi = nan id = cord-002945-29nj4f05 author = Ambrose, Rebecca K. title = In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c) date = 2018-01-19 keywords = BVDV-1; Day; animal summary = Detection of bovine viral diarrhoea virus 1 subgenotype 1c in extracts from cattle samples using quantitative real time PCR (qPCR). For cattle infected with BVDV-1c strain Trangie, one of the four animals tested positive on Day 2 post-infection, while all the other samples were negative throughout the sampling period (Table 1) . For cattle infected with BVDV-1c strain Trangie, one of the four animals tested positive on Day 2 post-infection, while all the other samples were negative throughout the sampling period (Table 1) . BVDV-1c was not detected via qPCR in the nasal swab or serum samples collected from all animals on Day 21, Day 28, Day 42 and Day 55 post-infection and were deemed to be negative (data not shown). BVDV-1c was not detected via qPCR in the nasal swab or serum samples collected from all animals on Day 21, Day 28, Day 42 and Day 55 post-infection and were deemed to be negative (data not shown). doi = 10.3390/pathogens7010012 id = cord-350024-whne0l19 author = Anderson, Victoria L. title = Choosing the Right Antibiotic in Ambulatory Care date = 2006-11-28 keywords = Lyme; day; diagnosis; treatment summary = With the use of a system-based approach, this article defines the most common infections seen in ambulatory care and their most common causative organisms and gives antibiotic options with respect to efficacy, common side effects, and cost. Nurse practitioners can diagnose and manage most of these skin infections; however, in the case of necrotizing fasciitis this is a surgical emergency and requires immediate referral and hospitalization.The following clinical entities most commonly seen in outpatient care are described: cellulitis, impetigo, folliculitis, furuncles and carbuncles, necrotizing fasciitis, paronychia, onychomycoses, lice, scabies, and Lyme disease. GAS is the most common bacterial cause and requires treatment with antibiotics; therefore, the main objective in evaluating a patient in the primary care setting is to identify, rule out, and treat GAS. This section discusses infections of the genitourinary tract, including vaginitis, cervicitis, cystitis, and epididymitis with specific reference to the diagnosis and management of sexually transmitted diseases (STDs). doi = 10.1016/j.nurpra.2006.09.009 id = cord-283257-rh3bxvv7 author = Andrejčáková, Zuzana title = Synbiotics suppress the release of lactate dehydrogenase, promote non‐specific immunity and integrity of jejunum mucosa in piglets date = 2015-12-21 keywords = Day; LDH; TLDH; probiotic summary = The impact of such additives on the release of lactate dehydrogenase (LDH; spectroscopic and electrophoretic assay), alteration of immunity (index of metabolic activity), jejunum histology (light microscopy), and health of conventional piglets from a problematic breed (monitoring of hematology, consistency and moisture of feces and body temperature) were examined. We found significant decrease in LDH leakage in the blood serum and tissue extracts, indicating better cell membrane integrity in the individual organs of animals. The aim of our study therefore was to examine the effect of synbiotics through flaxseed feed supplementation in combination with Lactobacillus plantarum -Biocenol TM LP96 (CCM 7512) and Lactobacillus fermentum -Biocenol TM LF99 (CCM 7514), on the activity of lactate dehydrogenase (LDH), alteration of immunity, jejunum histology and health of conventional piglets from a problematic breed. doi = 10.1111/asj.12558 id = cord-331347-imexhlwn author = Anzai, Asami title = Assessing the Impact of Reduced Travel on Exportation Dynamics of Novel Coronavirus Infection (COVID-19) date = 2020-02-24 keywords = China; day summary = Data on confirmed cases diagnosed outside China were analyzed using statistical models to estimate the impact of travel reduction on three epidemiological outcome measures: (i) the number of exported cases, (ii) the probability of a major epidemic, and (iii) the time delay to a major epidemic. We aim to estimate reductions in the number of exported cases, probability of an outbreak occurring outside China, and any time delay to a major epidemic that may be gained with these policies. The present study explicitly quantified the epidemiological impact of reduced travel volume to and from China on the transmission dynamics of COVID-19 outside China using simple statistical The solid lines represent the probability of a major epidemic in the counterfactual scenario, i.e., based on the expected number of cases diagnosed in Japan. doi = 10.3390/jcm9020601 id = cord-334667-0cah15lg author = Arabi, Yaseen M. title = Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial date = 2020-01-03 keywords = MERS; day; trial summary = title: Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial ABSTRACT: The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir and intErferon-β1b) investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant interferon-β1b provided with standard supportive care, compared to placebo provided with standard supportive care, in hospitalized patients with laboratory-confirmed MERS. Baseline characteristics will be presented for the two study groups (Additional file 1: Table S1 ) including age, sex, and body mass index, the presence of co-infections, nosocomial versus community-acquired MERS infection, Acute Physiology and Chronic Health Evaluation (APA-CHE) II scores, Sequential Organ Failure Assessment scores, and the Karnofsky Performance Status Scale score [3] . The MIRACLE trial investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant Interferon-β1b provided with standard supportive care, compared to placebo provided with standard supportive care, in hospitalized patients with laboratory-confirmed MERS. doi = 10.1186/s13063-019-3846-x id = cord-018110-mcw4v13c author = Arnold, Andreas title = Inner Ear date = 2010 keywords = Fig; Ménière; Sect; case; day; hearing; loss; patient; sensorineural; tinnitus; vestibular summary = In the case of partial or no remission, prednisolone treatment should be continued orally for 16 days together with gastric proton pump inhibitors and additional haemodilutive/haemorheological infusion therapy together with α-lipoic acid should be administered as described for high-frequency idiopathic sensorineural hearing loss. Acute tinnitus due to noise-induced damage or acoustic trauma of the inner ear, idiopathic sensorineural hearing loss (sudden deafness), acute attack of Ménière''s disease, toxic labyrinthitis, rupture of the round window, perilymphatic fistula of the round or oval window, labyrinthine contusion or fractures of the temporal bone due to head trauma should be treated with a daily dose of 250-500 mg prednisolone intravenously on three consecutive days. doi = 10.1007/978-3-540-68940-9_6 id = cord-275427-00bwhaga author = Aydogdu, Ugur title = The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis date = 2019-11-30 keywords = day; group; lamb; treatment summary = Abstract In this study, it was aimed to investigate the efficacy of chitosan oligosaccharide administrations in different doses of experimental infected lambs with Cryptosporidium parvum. As a result, in lambs with experimental cryptosporidiosis, chitosan oligosaccharide improved in clinical signs and stool character shorter than the positive control group and the administration of chitosan oligosaccharide at doses of 100, 500 and 1000 mg/kg for 7 days significantly reduced oocyst excretion but not enough to remove cryptosporidiosis completely. parvum in in vitro studies, we hypothesized that oral chitosan administration may be used in the treatment of lambs with experimentally cryptosporidiosis. The aim of this study was to determine the treatment efficacy of oral chitosan oligosaccharide in lambs with experimental cryptosporidiosis. According to the findings of this study, the use of chitosan oligosaccharide to be used in the treatment of experimental cryptosporidiosis at doses of 100 and/or 500 mg/kg was found to provide an earlier reduction in oocyst excretion compared to 1000 mg/kg dose. doi = 10.1016/j.smallrumres.2019.09.021 id = cord-336000-v88bq4bx author = Barco, Stefano title = Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial date = 2020-09-09 keywords = COVID-19; LMWH; SARS; VTE; day; line; patient; study summary = OBJECTIVES: The OVID study will demonstrate whether prophylactic-dose enoxaparin improves survival and reduces hospitalizations in symptomatic ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe systemic, pulmonary, and vessel inflammation and coagulation activation. The OVID study will show whether prophylactic-dose enoxaparin improves survival and reduces any hospitalizations in ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe systemic, pulmonary, and vessel inflammation and coagulation activation. <30% of the expected number of patients six months after the enrolment of the first patient, also based on the course of SARS-CoV2 infections in Switzerland;  when the safety of the participants is doubtful or at risk, respectively, based on recommendations received from DSMB committee;  changes in accepted clinical practice that make the continuation of a clinical trial unwise, including the results of similar studies or the publication of international guidances. doi = 10.1186/s13063-020-04678-4 id = cord-000097-vueo83vk author = Beretta, Chiara title = Prolonged extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome in a child affected by rituximab-resistant autoimmune hemolytic anemia: a case report date = 2009-04-01 keywords = AIHA; day; figure summary = title: Prolonged extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome in a child affected by rituximab-resistant autoimmune hemolytic anemia: a case report Recently, the use of monoclonal antibodies (rituximab) has allowed sustained remissions to be obtained in the majority of pediatric patients with refractory autoimmune hemolytic anemia. While still on steroid therapy, the patient developed an interstitial pneumonia with Acute Respiratory Distress Syndrome, which required immediate admission to the intensive care unit where extracorporeal membrane oxygenation therapy was administered continuously for 37 days. CONCLUSIONS: This case shows that aggressive combined immunosuppressive therapy may lead to a sustained complete remission in children with refractory autoimmune hemolytic anemia. One month after the end of the first course of rituximab, while still receiving low-dose steroids, the patient presented with a clinical relapse of AIHA, so prednisone was increased to 2mg/kg/day and two further rituximab infusions were performed ( Figure 1 ). doi = 10.1186/1752-1947-3-6443 id = cord-343349-ftzjdvfj author = Bhatt, P. N. title = Experimental infection of adult axenic rats with Parker''s Rat Coronavirus date = 1977 keywords = PRCV; SDAV; day summary = Virus was recovered from the nasopharynx and trachea after twenty-four hours and from the lung by day three but was not detected in respiratory tract after seven days. Viral antigen was detected by indirect immunofluorescence in the mucosal epithelium of upper respiratory tract and in pulmonary alveolar septae from day two to six postinoculation. Dacryoadenitis did not occur, sialoadenitis was detected in only three rats and virus was recovered from only one submaxillary salivary gland. Coronavirus infection is common in laboratory rats and two antigenically related viruses, sialodacryoadenitis virus (SDAV) and Parker''s rat coronavirus (PRCV), have been isolated from naturally-infected rats (2, 7) . Virus in lungs, tracheas, nasal washings, salivary glands and lacrimal glands was quantitated for individual rats. Virus was not detected in nasopharynx, trachea and lung a~ter day six and in other tissues after day seven except in ~he submaxillary salivary gland of one rat. doi = 10.1007/bf01314779 id = cord-349329-f0pbd968 author = Bosteels, Cedric title = Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial date = 2020-06-05 keywords = ARDS; COVID-19; CSF; Leukine; day; patient summary = -Presence of acute hypoxic respiratory failure defined as (either or both)  saturation below 93% on minimal 2 l/min O2  PaO2/FiO2 below 350 -Admitted to specialized COVID-19 ward -Age 18-80 -Male or Female -Willing to provide informed consent Exclusion criteria -Patients with known history of serious allergic reactions, including anaphylaxis, to human granulocyte-macrophage colony stimulating factor such as sargramostim, yeast-derived products, or any component of the product. Study Interventions Confirmed or highly suspect COVID-19 patients with acute hypoxic respiratory failure (saturation below 93% on minimal 2 l/min O2 or PaO2/FiO2 <350) will be randomized to receive sargramostim 125mcg twice daily for 5 days as a nebulized inhalation on top of standard of care (active group), or to receive standard of care treatment (control group). doi = 10.1186/s13063-020-04451-7 id = cord-033453-557obi3r author = Bretscher, Lorenzo title = COVID-19 and the Cross-Section of Equity Returns: Impact and Transmission date = 2020-09-24 keywords = Table; covid-19; day; firm; return summary = Using the first reported case of COVID-19 in a given U.S. county as the event day, we find that firms headquartered in an affected county experience, on average, a 27-bps lower return in the 10-day post-event window. The regression results show that the average daily return of a labor-intensive firm residing in a high intensity county is 1% lower in the 10-day post-event window. To this end, we use analysts'' forecast data from the I/B/E/S database and document that the first reported coronavirus case results in downward revision of earnings estimates of firms located in the same county. Second, and related, a unique advantage of our natural experiment is that it allows us to examine the relative strength of various channels (specifically, the labor supply channel, the uncertainty channel, the government policy channel, and the cash flow news channel) through which the COVID-19 shock affects firm valuations. doi = 10.1093/rapstu/raaa017 id = cord-324553-qd8249w3 author = Cadegiani, F. A. title = An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV Female Trial. date = 2020-10-06 keywords = COVID-19; October; day summary = The present study aimed to evaluate the effects of any early pharmacological approach to females diagnosed with COVID-19 before seven days of symptoms, as well as investigate whether HA is an additional risk factor in this population. Materials and methods: Females with symptoms for less than seven days confirmed for COVID-19 through positive real-time polymerase chain reaction (rtPCR-SARS-CoV-2) were classified and divided as non-HA, HA, and HA using spironolactone (HA-spiro) groups. Conclusions: A sensitive, early detection of COVID-19 followed by a pharmaceutical approach with different drug combinations yielded irrefutable differences compared to sex-, age-, body mass index (BMI)-, and disease-matched non-treated controls in terms of clinical outcomes, ethically disallowing placebo-control randomized clinical trials in the early stage of COVID-19 due to the marked improvements. Several different molecules demonstrated in vitro antiviral activity against SARS-CoV-2 and have been proposed as promising therapies for COVID-19 (13) , among which the most attempted drug combinations included azithromycin in the majority of the cases, in association with hydroxychloroquine, ivermectin or nitazoxanide (13, 14) . doi = 10.1101/2020.10.05.20206870 id = cord-292970-32mql9nq author = Camdessanche, Jean-Philippe title = COVID-19 may induce Guillain-Barré syndrome date = 2020-04-15 keywords = day summary = key: cord-292970-32mql9nq title: COVID-19 may induce Guillain-Barré syndrome journal: Rev Neurol (Paris) DOI: 10.1016/j.neurol.2020.04.003 cord_uid: 32mql9nq In the context of COVID-19 pandemic, SARS-CoV-2 RT-PCR on nasopharyngeal swab was performed and positive. Clinical presentation was moderate with high grade fever for three days requiring oxygen 2-3 L/min through nasal cannula for five days. Eleven days after the symptom onset, while he did not need oxygen anymore having had no fever for five days, the patient complained of paresthesia in feet and hands. In three days, he Covid-19 pandemic is a worldwide disaster. Pulmonary disorder and respiratory insufficiency are the main problems linked to SARS-CoV-2 infection, which explains difficulties in ICU to treat numerous patients [2] . questioned the link between COVID-19 and GBS [3] . Our case is the first GBS with a chronology undoubtedly in favor of a complication of COVID-19 infection. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? doi = 10.1016/j.neurol.2020.04.003 id = cord-287520-51kmd2ds author = Carneiro, Arie title = Impact of the COVID-19 Pandemic on the Urologist’s clinical practice in Brazil: a management guideline proposal for low- and middle-income countries during the crisis period date = 2020-05-20 keywords = Cancer; case; covid-19; day; patient summary = Therefore, most worldwide authorities are recommending to avoid, as much as possible, patient''s elective visits to hospitals, as well as a judicious use of the operating room in order to mitigate the strain put on the health system. If it is not possible to separate an entire surgical block, we suggest designating specific rooms for the care of patients with COVID-19 that will not be used for regular cases. The gold standard test for investigation of the upper urinary tract is uro-tomography, but in times when we need to consider the use of resources, ultrasound could potentially be used since many imaging services are overloaded due to the frequent indication of thoracic CTs for the diagnosis and follow-up of patients with Sars-Cov-2. -In Intermediate-risk and high-risk non--muscle-invasive bladder cancers: Clinically fit patients with no major comorbidities should receive induction therapy followed by at least 1-year maintenance BCG. doi = 10.1590/s1677-5538.ibju.2020.04.03 id = cord-282268-f7mbdfr6 author = Cartenì, Armando title = How mobility habits influenced the spread of the COVID-19 pandemic: Results from the Italian case study date = 2020-06-24 keywords = Italy; covid-19; day summary = By contrast, the hypothesis discussed in this research is that the time period (days) in which a new positive case of coronavirus is identified and certified, which could be called a sort of a positivity detection time, is longer than the incubation time because of possible delays between contagion and detection caused, for example, by the significant percentage of tests that prove false negative to COVID-19, or by the fraction of people who, although infected, are asymptomatic and/or initially show only mild symptoms, and therefore do not resort to health care. Estimates were made through a multiple linear regression model linking the number of certified daily cases (day-to-day) to socio-economic indices (e.g. number of residents; population density), environmental variables (e.g. temperature, PM pollution), health care indicators (e.g. number of swabs taken daily) and mobility habits (e.g. number people who performed trips several days before). doi = 10.1016/j.scitotenv.2020.140489 id = cord-309588-kw4d32dt author = Chan, Michael H.M. title = Steroid-induced osteonecrosis in severe acute respiratory syndrome: a retrospective analysis of biochemical markers of bone metabolism and corticosteroid therapy date = 2006-06-30 keywords = BALP; Day; SARS summary = Summary Aim We investigated the effect of massive doses of corticosteroid therapy on bone metabolism using specific biochemical markers of bone metabolism, and the prevalence of osteonecrosis in severe acute respiratory syndrome (SARS) patients at a university teaching hospital in Hong Kong. Biochemical markers of bone metabolism were analysed retrospectively using serial clotted blood samples collected from each patient during the course of hospital admission to discharge and subsequent follow-up at out-patient clinic using the arbitrary time periods: (i) Day <10; (ii) Day 28-44; (iii) Day 51-84; and (iv) Day >90 after the onset of fever. Aim: We investigated the effect of massive doses of corticosteroid therapy on bone metabolism using specific biochemical markers of bone metabolism, and the prevalence of osteonecrosis in severe acute respiratory syndrome (SARS) patients at a university teaching hospital in Hong Kong. 9, 10 In this study, biochemical markers of bone metabolism were used retrospectively to investigate the effect of massive doses of pulse and maintenance corticosteroid therapies on patients with SARS. doi = 10.1080/00313020600696231 id = cord-337454-0h28a3az author = Chartier, C. title = Prophylaxis using paromomycin of natural cryptosporidial infection in neonatal kids date = 1996-01-31 keywords = day; kid summary = The first group consisted of 18 kids; of these, nine had been born on 9 February and had been treated with paromomycin; the other nine, born 2 days later were untreated controls. Except for the medicated kid from the second trial, all animals showed a distension of small and large intestines by Table 2 Comparison of cryptosporidial oocyst shedding score in treated ( paromomycin from day 2 to day 13 of age) and untreated kids; trial 2 Moreover, in the first group of animals where control kids were severely affected, paromomycin prevented diarrhea and mortality. At the end of the studies, on days 15-19, oocyst excretions of medicated animals did not differ from those of the controls. Recent studies conducted in calves at 60-120 pg kg-'' for 7 days in experimental conditions (Naciri et al., 1993) should be duplicated in kids in field conditions and compared with the paromomycin prophylaxis schedule in order to define the most effective and convenient way to control cryptosporidiosis in goats. doi = 10.1016/0167-5877(95)00511-0 id = cord-007064-nepgttxf author = Chemaly, Roy F title = A Phase II, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients date = 2019-12-03 keywords = Inc.; RSV; Sciences; day summary = title: A Phase II, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients This is the largest randomized, double blind, placebo-controlled clinical trial to date for the treatment of allogeneic and autologous HCT recipients with RSV URTIs. Presatovir treatment did not meet the coprimary endpoints of a greater time-weighted average change in the RSV viral load from Day 1 to 9 and the reduced development of LRTCs through Day 28, but was well tolerated, with a comparable safety profile relative to the placebo. In a post hoc analysis of patients with lymphopenia, the proportion who developed an LRTC through Day 28 was 51% lower following treatment with presatovir, as compared to the placebo; other post hoc analyses also indicated trends toward a treatment effect on LRTCs. The results suggest lessons for the design of future clinical trials of drugs for RSV or other respiratory viruses in transplant recipients or other immunocompromised patients. doi = 10.1093/cid/ciz1166 id = cord-010130-28bt3x25 author = Crocchiolo, R. title = Infections after T‐replete haploidentical transplantation and high‐dose cyclophosphamide as graft‐versus‐host disease prophylaxis date = 2015-03-26 keywords = CMV; HSCT; day summary = RESULTS: After a median follow‐up of 23 months, cumulative incidence of viral infections was 70% (95% confidence interval [CI] 59–81) at 100 days and 77% (95% CI 67–87) at 1 year; 35 of 65 patients at risk had CMV reactivation (54%) and the rate of polyomavirus‐virus‐associated cystitis was 19% (13/70). In the present analysis, we described infectious complications after unmanipulated, T-cell replete haplo-HSCT using post-transplant Cy in 70 consecutive patients and found, aside from a high incidence of viral infections/reactivations, especially in the early posttransplant period, a quite low incidence of late bacterial infections, together with a very low incidence of IFIs after day +180 (2 events in the overall 11 observed). In conclusion, the present single-center data on 70 consecutive patients receiving T-cell replete haplo-HSCT with post-transplant Cy confirm a high rate of viral infections before day +100 and a lower incidence of infections afterward, suggesting a satisfactory although non-optimal immune reconstitution after this type of transplantation. doi = 10.1111/tid.12365 id = cord-258696-01wj76es author = Decaro, Nicola title = Experimental infection of dogs with a novel strain of canine coronavirus causing systemic disease and lymphopenia date = 2008-04-30 keywords = RNA; day; dog summary = The dogs, three 2.5-month-old and two 6-month-old pups, were successfully infected, shedding viral RNA with their faeces for the entire observation period (21 days) and displaying systemic clinical signs resembling those observed during the course of natural infection. At postmortem examination, remarkable lesions were observed in the internal organs of the euthanized pups, that tested positive for CCoV by real-time RT-PCR and virus isolation on cell cultures. Unexpectedly, CCoV type II RNA was detected at very high titres in the internal organs of the dead pups and the virus (strain CB/05) was isolated on canine cell cultures. (last day of observation) reaching the maximal mean value of 6.79 Â 10 5 RNA copy numbers/ml of template at day 10 p.i. Surprisingly, CCoV RNA was never detected in the blood of the 6-month-old pups, as well as in the euthanized animals, in whose organs remarkable viral RNA titres were found. doi = 10.1016/j.vetmic.2007.10.008 id = cord-021555-rrverrsj author = Delano, Margaret L. title = Biology and Diseases of Ruminants: Sheep, Goats, and Cattle date = 2007-09-02 keywords = Smith; States; United; animal; bovine; cattle; cause; clinical; day; diagnosis; differential; disease; etiology; goat; infection; lesion; necropsy; organism; ruminant; sheep; sign; treatment; virus summary = These references also provide information regarding vaccination products licensed for use in ruminants and typical herd and flock vaccination parasite control schedules ("Current Veterinary Therapy," 1986 , 1999 "Council report," 1994; "Large Animal Internal Medicine," 1996; Smith and Sherman, 1994) When designing a vaccination program during qualification of a source or at the research facility, it is important to evaluate the local disease incidence and the potential for exposure. Clinical signs in chronic cases in older animals, such as adult goats, include soft stools, weight loss, anorexia, depression, and severe diarrhea, sometimes with mucus and blood. This pathogen does present a complication due to the carrier status of some animals, the likelihood of herd outbreaks, the severity of disease in younger animals, and the morbidity, possible progression to uveitis, and time and treatment costs associated with infections. doi = 10.1016/b978-012263951-7/50017-x id = cord-347140-q8qis03p author = Dietz, Thomas title = Earth Day: 50 Years of Continuity and Change in Environmentalism date = 2020-04-17 keywords = Day; Earth summary = The first Earth Day took place on April 22 in the midst of this instability, and its campaigns and the environmental movement it birthed were inevitably influenced by the politics of the time. Although the event was heavily influenced by the US politics of the time, from an environmental perspective Earth Day crystallized the convergence of several themes that would define environmentalism for the decades that followed. In the case of climate change, although the proportion of the public who are concerned has increased over the last decade, a strong ideological split between Democrats and Republicans persists. Thus, as in 1970, we need to find ways to link scientific analysis to political action and overcome the polarization that has shaped and defined environmentalism in the US for the past half-century. Political polarization and long-term change in public support for environmental spending doi = 10.1016/j.oneear.2020.04.003 id = cord-021453-vf8xbaug author = Dysko, Robert C. title = Biology and Diseases of Dogs date = 2007-09-02 keywords = Animal; Ferguson; Peterson; Swaim; Veterinary; canine; cause; cell; clinical; day; diagnosis; disease; dog; infection; research; sign; treatment; tumor; wound summary = The use of dogs continued as biomedical research advanced, and they were featured in many noteworthy studies, including those by Pavlov to observe and document the conditioned reflex response and by Banting and Best to identify the role of insulin in diabetes mellitus. Especially noted in this chapter are infectious diseases associated with the use of random-source dogs that have unknown vaccination history and have had intensive contact with other similar animals at pounds and/or shelters, or conditions seen frequently in the beagle, the most common breed used in biomedical research. Culture requires selective isolation media, and growth is favored by reduced oxygen tension and a temperature of 42~ Any disorder that can cause diarrhea in dogs should be considered as a differential diagnosis, including canine parvovirus, coronavirus, distemper virus, Giardia, and Salmonella infections; helminth infestations; and hemorrhagic gastroenteritis. doi = 10.1016/b978-012263951-7/50014-4 id = cord-305365-50uojtet author = Easson, Will title = A review of rabbit and rodent production medicine date = 2001-07-31 keywords = cause; day; female; rabbit; week summary = This review article outlines the essentials of production medicine (factors affecting production colony output) in rabbits and rodents, emphasizing the importance of routine management methods and record-keeping as well as disease control. Dystocia is not a common problem in rabbits, but when seen it is usually caused by obesity, a large fetus (particularly in small litters), or malpresentation. Infertility can be caused by the following factors: obesity; nutritional deficiencies; metritis; high environmental temperatures (>29~ poor lighting (low intensity or <10 hours/day); disease (eg, respiratory infection, skin mites, gastrointestinal disease, cystic ovaries); overcrowding; aged boars or sows; and mechanical impediments (eg, sawdust or the waxy secretion boars accumulate in their groin and scrotal regions). It is caused by the energy requirements of the last stages of gestation and of increasing lactation, particularly in primiparous obese sows that become anorexic for any reason (eg, any stress or disease) or who have a low-energy diet in this critical month. doi = 10.1053/saep.2001.24252 id = cord-265891-jmpterrj author = Eilersen, Andreas title = Cost–benefit of limited isolation and testing in COVID-19 mitigation date = 2020-10-29 keywords = contact; day; quarantine summary = Therefore, we will here implement a crude form of contact tracing where we (1) close the workplaces of people who are tested positive for the disease, (2) isolate their regular social contacts for a limited period, and (3) keep symptomatic individuals in quarantine until they recover. If 10% efficiency is possible, corresponding to detecting about a third of infectious cases, then peak height could be reduced by a factor of almost three with to a 60% drop, if the probability of infected people being tested is only 10% per day of illness. In Fig. 4 , we show two possible scenarios where testing and contact tracing is implemented after a 30-day lockdown with a 75% reduction of the work and social spheres. Using reasonable COVID-19 infection parameters we find that the 1STQ strategy can contribute to epidemic mitigation, in the sense that it can reduce the peak number of infected individuals by about a factor of two even with a realistic testing rate of 10% per day of illness. doi = 10.1038/s41598-020-75640-2 id = cord-007178-h0ordzm9 author = Felts, Paul A. title = Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide date = 2005-05-04 keywords = Fig; LPS; cell; day; dorsal; injection summary = At this interval the lesion was clearly discernible using differential interference contrast optics as a region of tissue disruption in the dorsal funiculus, allowing AdPC-positive cells to be counted in both demyelinated and apparently normal areas of the dorsal funiculus of LPS-injected animals. Spinal cords injected with saline ( Fig. 1) showed damage restricted to a very small number of axons undergoing either Table 1 Populations of inflammatory cells present in the spinal cord at various times following the injection of LPS or saline into the dorsal funiculus Wallerian degeneration or demyelination. The cells were often adjacent to large blood vessels, and they formed only a small subset of the substantial population of ED1-positive Fig. 7 Light micrographs showing GFAP immunoreactivity at the interface between the dorsal funiculus (DF) and the grey matter (GM) in an animal 7 days after the injection of LPS into the spinal cord. doi = 10.1093/brain/awh516 id = cord-032806-o6p861ms author = Fenin, Audrey title = Very low birth weight infants receive full enteral nutrition within 2 postnatal weeks date = 2020-09-29 keywords = Epoch; day; infant summary = STUDY DESIGN: Very low birth weight infant cohort admitted in the first postnatal day and categorized as either Epoch 1 or Epoch 2, 12 months before and after implementation of a revised feeding protocol were compared. Despite the lack of difference in 2-year outcomes including survival without moderate or severe neurodevelopmental disability in this trial [9] , neonatal care centers may still find benefit if more rapid advancement of enteral feeds is associated with two common quality indicators in neonatal care-early discontinuation of central venous lines (CVL) and shorter duration of parenteral nutrition (PN), while maintaining infant growth. Therefore, this cohort study, with a retrospective control, was performed with a primary aim to determine if infants were able to reach the full enteral nutrition goal and with secondary aims to determine whether this outcome was associated with changes in PN exposure, CVL days, or growth. doi = 10.1038/s41372-020-00819-4 id = cord-027811-vk3qnumx author = Freedberg, Daniel E. title = Impact of Fiber-Based Enteral Nutrition on the Gut Microbiome of ICU Patients Receiving Broad-Spectrum Antibiotics: A Randomized Pilot Trial date = 2020-06-11 keywords = ICU; SCFA; day summary = title: Impact of Fiber-Based Enteral Nutrition on the Gut Microbiome of ICU Patients Receiving Broad-Spectrum Antibiotics: A Randomized Pilot Trial CONCLUSIONS: Enteral fiber was associated with nonsignificant trends toward increased relative abundance of short-chain fatty acid–producing bacteria and increased short-chain fatty acid levels among ICU patients receiving broad-spectrum IV antibiotics. This pilot study was designed to test the hypothesis that fiber-based enteral nutrition increases the levels of SCFA-producing bacteria and SCFA levels in ICU patients receiving broad-spectrum IV antibiotics, with a goal of generating effect size estimates that could be used as the basis for future studies involving fiber. A study testing 7 days of 7 g/d inulin versus maltodextrin supplementation in 22 ICU adults initiating enteral nutrition found no difference in fecal abundance of Faecalibacterium prausnitzii or Bifidobacteria, or in fecal SCFA levels (24) . doi = 10.1097/cce.0000000000000135 id = cord-002659-566uoozj author = Fujimoto, Yousuke title = Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection date = 2017-08-22 keywords = H1N1; day; infection summary = Cytokine levels and virus titres in bronchoalveolar lavage fluid from mice with and without asthma after A(H1N1)pdm09 or seasonal H1N1 infection were examined. Virus titres in asthma/A(H1N1)pdm09 mice were highest at 3 days post-infection, and decreased by 7 days post-infection, although the levels at this time point were still higher than that in any other group. In the present study, we investigated the sequential changes in intra-tracheal cytokine production, viral loads, and pulmonary inflammation in a mouse model of bronchial asthma during the first 7 days after A(H1N1)pdm09 or seasonal H1N1 influenza infection. In contrast, the levels in control mice increased to 161.4 pg/mL by 3 days post-seasonal virus infection, which were similar to those in asthma/A(H1N1)pdm09 mice (p = 1.00), and these levels were maintained until 7 days post-infection. The notable findings in the present study were the early peak in both IL-6 and TNF-α levels, the high inflammatory cell infiltration in BAL fluids, and the severe pulmonary inflammation at 3 days post-infection in asthmatic/A(H1N1)pdm09 mice. doi = 10.1038/s41598-017-08030-w id = cord-009772-pzxvicee author = GRÜNBERG, K. title = Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo date = 2006-04-27 keywords = IL-8; cold; day summary = title: Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo Conclusion We conclude that the severity of cold, as induced by experimental RV16 infection, is a determinant of the increase in airway hypersensitivity to histamine in patients with asthma. Since none of these studies was placebo-controlled, it seems mandatory to examine the effect of experimental rhinovirus infection on airway sensitivity to histamine in asthmatic subjects by using such a design. In the present study, we hypothesized that experimental RVI6 colds in atopic asthmatic patients increase airway sensitivity to histamine. During the course of the study, there were no significant effects on baseline FEV| within either the placebo group or in the RVl 6-treated subjects with a mild or severe cold (MANOVA, P -0.99) ( Figure 1 ). Two previous studies on experimental rhinovirus infection in asthma [!3.14| showed small and variable changes in airway hypersensitivity. doi = 10.1111/j.1365-2222.1997.tb00670.x id = cord-002957-gw2cow0d author = Gray, Darren W. title = DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles date = 2018-04-05 keywords = UPLC; animal; bpi3v; day; vaccinated summary = The aims of the current study were therefore to assess the performance of Reverse Phase (RP) and Hydrophobic Interaction Liquid Chromatography (HILIC) separation methods for Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) metabolomic profiling of bovine plasma and identify plasma metabolomic markers capable of differentiating between vaccinated and nonvaccinated calves following intranasal challenge with BPI3V. The selected panel of 383 unique AMRTPs (S3 Table) differentiating animals of different vaccination status at various time-points post-BPI3V challenge were deconvoluted to identify parent ion mass, adducts and low energy fragments using low and high energy data (Function 1 and 2 respectively), yielding 26 parent ions for elemental composition determination. The metabolomic profiling performed here in this study on post-BPI3V challenge acquired samples, has identified a unique panel of plasma metabolites which differ between vaccinated and non-vaccinated animals, and significantly are involved in recognised immune response mechanisms. doi = 10.1371/journal.pone.0194488 id = cord-333522-zsdymkjd author = Gruse, Jeannine title = Quercetin Feeding in Newborn Dairy Calves Cannot Compensate Colostrum Deprivation: Study on Metabolic, Antioxidative and Inflammatory Traits date = 2016-01-11 keywords = Fig; calf; colostrum; day; feed summary = Blood samples were taken repeatedly to measure plasma concentrations of flavonols, glucose, lactate, total protein, albumin, urea, non-esterified fatty acids, triglycerides, cholesterol, insulin, glucagon, cortisol, immunoglobulins, fibrinogen, haptoglobin and serum amyloid A. Basal blood samples were taken before the morning feeding on days 1, 2, 4 and 7 from the jugular vein using evacuated tubes containing either potassium-EDTA (1.2-2 mg/mL EDTA) for analyses of plasma metabolites, insulin, glucagon, immunoglobulins and acute-phase proteins or Li-heparin (12-30 IU heparin) for the determination of the cortisol and flavonol concentrations and the antioxidative status in the plasma. Feed intake, body temperature, heart and respiratory rate and plasma concentrations of metabolites, hormones, flavonols and markers of antioxidative status were analyzed by repeated measurement ANOVA using the MIXED procedure of SAS/STAT software and a model with the fixed factors diet, quercetin and day of life (repeated variable) and all interactions between the fixed factors. doi = 10.1371/journal.pone.0146932 id = cord-275889-4qwp3um1 author = Guarnieri, M. title = Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats date = 2017-04-09 keywords = day; dose; rat summary = The intended label dose of 0.65 mg/kg, which provides 2-3 days of clinically significant blood levels of drug, was established in bioequivalence trials and efficacy studies to be described using male and female rats. In the single-dose phase of the trials, 4 groups of 8 rats (4 male, 4 female) were dosed after surgery (described below) with 0.0 (vehicle control), 1.3 (2x), 3.9 (6x), or 6.5 (10x) mg/kg drug suspension of buprenorphine on day 0. In the repeat-dose trials, 4 groups of 8 rats (4 male, 4 female) were dosed after surgery with the vehicle control or drug suspensions containing 1.3, 3.9, or 6.5 mg/kg of buprenorphine on day 0 and following anesthesia on days 4 and 8. Male and female rats were provided with a single dose of drug and sampled at time intervals from 8 hours to 9 days to measure blood concentrations of buprenorphine. doi = 10.1155/2017/3102567 id = cord-268081-ytx6sf3x author = Guionie, Olivier title = An experimental study of the survival of turkey coronavirus at room temperature and +4°C date = 2013-04-22 keywords = EID; day summary = As TCoV does not induce lesions in the embryo, virus replication in the jejunum and ileum of the embryos was detected 4 days post inoculation, using RNA extraction and a real-time reverse transcriptase-polymerase chain reaction based on the nucleocapsid gene. However, infectious virus was still detected after 20 days storage at the cooler temperatures, a finding that suggests prolonged survival of Fr TCoV and easier transmission between poultry farms in a cool environment are possible. The first duplicates harvested after different times of storage at the different temperatures were used to test for the presence of residual infectious virus in the sample by inoculating SPF embryonated turkey eggs as described above. However, when the same samples were inoculated into embryonated SPF turkey eggs, viral RNA was detected in the digestive tracts of the inoculated embryos after 0 days of storage (27.5 Ct), but not after 42 or 40 days ( 40 Ct) at room temperature or ''48C, respectively. doi = 10.1080/03079457.2013.779364 id = cord-295633-vkjcheaz author = Hao, Xin‐yan title = The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose‐only exposure device date = 2019-10-30 keywords = East; MERS; Middle; day summary = After infection, we analyzed the mouse characteristics of weight loss, survival, viral replication, tissue pathology, viral antigen distribution, and cytokine and chemokine profiles, which provide additional data to investigate the pathogenesis of MERS-CoV-induced disease and evaluate relevant therapeutics and vaccines. Instillation control DMEM suspension To analyze clinical signs, weight loss, and survival On days 3, 5, 7, and 9 postinfection, three animals randomly selected from each group underwent necropsy to obtain tissue specimens for assessing viral distribution, associated histopathology, and cytokine levels using quantitative reverse transcription-PCR (qRT-PCR), hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA). *P < .05, **P < .01, ***P < .001, and ****P < .0001 Mice in the instillation group died acutely or were euthanized when they researched 25% weight loss; these mice had a 0% survival rate by day 5, so no tissue lesion results were available on days 7 and 9 mice infected with MERS-CoV via the aerosol inhalation or intranasal instillation route, but no obvious lesions were found in other tissues. doi = 10.1002/ame2.12088 id = cord-276338-wpo1eyeg author = Hesse, Amke title = In toxic demyelination oligodendroglial cell death occurs early and is FAS independent date = 2009-10-22 keywords = FAS; cell; cuprizone; day summary = During the initial phase of the cuprizone diet (days 6 and 10), but not during later stages (day 21), activated caspase 3 can be detected in apoptotic oligodendrocytes, suggesting that caspase 3-independent pathways trigger oligodendroglial cell death in later stages. In line with the notion of continuous oligodendroglial cell death, we found a significant decrease in the number of Nogo-A-positive mature oligodendrocytes in mice fed with cuprizone after 10 (540 ± 187 cells/mm 2 ) and 21 days (17 ± 15 cells/mm 2 ) compared to untreated controls (1797 ± 404 cells/mm 2 ) (Fig. 2b) . The number of apoptotic cells, Nogo-A-positive oligodendrocytes, activated caspase 3-expressing oligodendrocytes, macrophages and astrocytes, as well as the extent of demyelination, was determined on days 4, 6 and 10 and in mice fed with a cuprizone-free diet (controls). In the cuprizone model, apoptotic oligodendrocytes express activated caspase 3, and this is associated with a significant increase of FAS mRNA in the corpus callosum. doi = 10.1016/j.nbd.2009.10.016 id = cord-346836-6jyv0q5e author = Ikegami, Tetsuro title = The Pathogenesis of Rift Valley Fever date = 2011-05-06 keywords = IFN; RVFV; Rift; day; fever; infection; valley; virus summary = RVFV infection in humans usually causes a self-limiting, acute and febrile illness; however, a small number of cases progress to neurological disorders, partial or complete blindness, hemorrhagic fever, or thrombosis. This review describes the pathology of RVF in human patients and several animal models, and summarizes the role of viral virulence factors and host factors that affect RVFV pathogenesis. RVFV infection in humans primarily causes a self-limiting febrile illness; however, some patients develop hemorrhagic fever, neurological disorders, or blindness after the febrile period [5, 7, 8] . Inbred rat strains mimic the disparate human response to rift valley fever virus infection Clinical, virological and serological response of the west african dwarf sheep to experimental infection with different strains of rift valley fever virus doi = 10.3390/v3050493 id = cord-003533-8m0vyxq8 author = Jayathilaka, P. G. N. S. title = An outbreak of leptospirosis with predominant cardiac involvement: a case series date = 2019-03-18 keywords = day; leptospirosis; patient summary = We present a case series of severe leptospirosis with cardiac involvement observed during a period of one month at Colombo-North Teaching Hospital, Sri Lanka. CASE PRESENTATION: We report here five patients with severe leptospirosis complicated with cardiac involvement, admitted to a single medical ward, Colombo-North Teaching Hospital, Sri Lanka during a one-month period. In this case series, we describe a series of male patients with severe leptospirosis with cardiac involvement, presented to a single medical ward during a period of one month. By day eleven of illness he was completely recovered clinically and full blood count, liver function tests, renal function tests and ECG were normal. Patient was discharged from the ward on day 7 of illness with complete recovery and normal full blood count, renal and liver function tests. Despite adequate fluid resuscitation patient developed shock with low urine output on the same day of admission. doi = 10.1186/s12879-019-3905-7 id = cord-014538-6a2pviol author = Kamilia, Chtara title = Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date = 2017-01-10 keywords = ARDS; Antoine; Ben; Care; ECMO; EEG; Fig; France; François; ICU; Intensive; January; Jean; Mohamed; NIV; Nicolas; Pierre; VAP; acute; associate; day; group; high; mortality; patient; study summary = Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). doi = 10.1186/s13613-016-0224-7 id = cord-033791-q0wizf2n author = Kavirayani, Akhila title = The Lazarus effect of very high-dose intravenous anakinra in severe non-familial CNS-HLH date = 2020-10-15 keywords = day summary = title: The Lazarus effect of very high-dose intravenous anakinra in severe non-familial CNS-HLH Abbreviations: BAL -bronchoalveolar lavage, CRP -C-reactive protein, TRAPS -Tumour necrosis factor receptor-associated periodic syndrome, WCC -white cell count, FHL -Familial Haemophagocytic lymphohistiocytosis IV methyl prednisolone, 1 dose of IV Immunoglobulin, empiric antibiotics and antivirals-IV aciclovir and IV ceftriaxone, switched to meropenem/teicoplanin upon deterioration (doxycycline/clindamycin/co-amoxiclav also administered subsequently with co-trimoxazole/fluconazole prophylaxis) Inotropes for profound hypotension. Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis Benefit of Anakinra in Treating Pediatric Secondary Hemophagocytic Lymphohistiocytosis Successful treatment of severe paediatric rheumatic disease-associated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: case series with 12 patie nts Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome Therapeutic Role of Anakinra, an Interleukin-1 Receptor Antagonist, in the Management of Secondary Hemophagocytic Lymphohistiocytosis/Sepsis/Multiple Organ Dysfunction/Macrophage Activating Syndrome in Critically Ill Children*: Pediatric Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab: Alemtuzumab for Refractory HLH Pediatric CNS-isolated hemophagocytic lymphohistiocytosis doi = 10.1016/s2665-9913(20)30361-1 id = cord-280242-2w2kl0uf author = Kaya, Yildiz title = Transient cortical blindness in COVID-19 pneumonia; a PRES-like syndrome: A case report date = 2020-04-28 keywords = day summary = It has been reported that, in addition to the respiratory tract infection symptoms, patients can also have neurologic signs and symptoms; like acute cerebrovascular disease, polyneuritis, encephalitis and encephalopathy 2. Brain magnetic resonance imaging (MRI) showed bilateral, especially left occipital, frontal cortical white matter and splenium of corpus callosum T2/Fluid-attenuated inversion recovery (FLAIR) hyperintensities and diffusion restriction in diffusion weighted imaging (DWI) (Figure 2 ) revealing vasogenic edema similar to posterior reversible leucoencephalopathy (PRES). Recent autopsy reports have revealed that, like many viral infections SARS-CoV-2 can cause brain tissue edema and partial neuronal degeneration [3] . Infectious toxic encephalopathy is a reversible brain dysfunction syndrome caused by systemic toxemia, metabolic disorders and hypoxia during the process of acute infection [4] . Although we could not determine the exact ethiology in our case, regulating the blood pressure controlling the vasogenic edema by corticosteroid treatment and controlling the virus related pneumonia have helped fort he recovery of our patient. doi = 10.1016/j.jns.2020.116858 id = cord-031315-p7jb4gf2 author = Kong, Qing title = Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial date = 2020-09-03 keywords = COPD; China; TCM; day; exacerbation; trial summary = title: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial The present study aims to evaluate the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations and to investigate whether the short-term (5-days) systemic glucocorticoid therapy is non-inferior to the long-term (9-day) regime. On one hand, a dose of 40 mg prednisone (a common oral systemic glucocorticoid) daily for 5 days has been recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Science Committee Report based on the REDUCE randomized clinical trial since 2015 [24] . We conducted a randomized and placebo-controlled trial enrolling stable COPD patients in 2014, which illustrated that TCM formulas called Bushen Yiqi (BY) formulas can improve the lung function, reduce the frequency of acute exacerbation of COPD, and modulate the HPA axis [35] . doi = 10.1186/s13063-020-04669-5 id = cord-300810-a1skdp67 author = Lafay, F. title = Spread of the CVS strain of rabies virus and of the avirulent mutant AvO1 along the olfactory pathways of the mouse after intranasal inoculation date = 1991-07-31 keywords = CVS; cell; day; virus summary = title: Spread of the CVS strain of rabies virus and of the avirulent mutant AvO1 along the olfactory pathways of the mouse after intranasal inoculation Abstract After intranasal instillation in the mouse, rabies virus (CVS strain) selectively infected olfactory receptor cells. On the other hand, other neuronal cells permissive for CVS, such as mitral cells or the anterior olfactory nucleus, are completely free of infection with the mutant, indicating that restriction is related to the ability of AvO1 to penetrate several categories of neurons. The G protein plays a pivotal role in the pathogenicity of the virus because of its interaction with the host cells '' Abbreviations used: AON, anterior olfactory nucleus; CNS, central nervous system; GABA, Gamma aminobutyric acid; HDB, horizontal limb of the diagonal band; HRP, horseradish peroxidase; HSVl, herpes simplex type 1; IPL, internal plexiform layer: LC, locus coeruleus; LD50, lethal dose 50%; LPA. doi = 10.1016/0042-6822(91)90145-2 id = cord-306705-adshd3jj author = Lenander-Lumikari, Marianne title = Effects of the common cold and intranasal fluticasone propionate treatment on mucosal host defense assessed by human saliva()()() date = 2005-11-04 keywords = day summary = title: Effects of the common cold and intranasal fluticasone propionate treatment on mucosal host defense assessed by human saliva()()() 11 To extend these findings, this study analyzed salivary flow rate and selected major host antimicrobial components present in whole saliva in patients with the common cold. The purpose of this investigation was to study the effect of a potent topical steroid, fluticasone propionate, on patients with early signs and symptoms of the common cold. Salivary flow rate, innate host defense factors, and total protein content were not affected by the common cold. Salivary flow rate, innate host defense factors, and total protein content were not affected by the common cold. Neither the common cold nor the fluticasone propionate treatment had any effect on the relative amounts of secreted IgG or IgM immunoglobulins. Therefore, the salivary IgA response was probably induced by the viruses, and the treatment of the common cold with fluticasone propionate did not have any negative influence on this defense factor. doi = 10.1016/s1079-2104(99)70163-0 id = cord-324345-j43rpvwk author = Leong, Hoe Nam title = SARS – My personal battle date = 2010-11-19 keywords = SARS; Singapore; day summary = I vividly remember the time when I first saw the index patient with Severe Acute Respiratory Syndrome (SARS) in Singapore. The index patient was admitted to Tan Tock Seng Hospital (TTSH) on Saturday, (1st March 2003), and an infectious disease consult was sought on the following Monday. It was an exceedingly busy day for me as I had to attend to new referrals, run an outpatient clinic, and subsequently draft a clinical summary of these two patients by the early evening. Eventually, the patient''s fever defervesced on day 14 of illness. I wasn''t scheduled to perform the ward round that day, but I returned to visit the patient that Sunday morning. My wife and I telephoned a colleague in Singapore and we concurred to have a full blood count test done at the clinic the next day. My wife eventually joined me when she developed fever at the end of the second day of arrival. With that news, my days as a patient in isolation continued. doi = 10.1016/j.tmaid.2010.10.007 id = cord-327045-hn8pmcto author = Li, Yao title = Quercetin, Inflammation and Immunity date = 2016-03-15 keywords = cell; day; effect; quercetin summary = In vitro and some animal models have shown that quercetin, a polyphenol derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory and antiviral activities; as well as attenuating lipid peroxidation, platelet aggregation and capillary permeability. A study demonstrates that quercetin has a direct regulatory effect on basic functional properties of immune cells which may be mediated by the extracellular regulated kinase 2 (Erk2) mitogen-activated protein (MAP) kinase signal pathway in human mitogen-activated PBMC and purified T lymphocytes [54] . Quercetin most likely universally suppresses the accumulation and activation of immune cells, including anti-inflammatory cells, whereas it specifically increased gene expression associated with mitochondrial oxidative phosphorylation in Western diet-induced obese mice. showed that a supplement of 1000 mg of quercetin alone three weeks before, during and two weeks after a three-day period of 3 h of cycling in the winter resulted in a markedly lower incidence of URTI in well-trained subjects in the two weeks after the intensified training, but had no effect on exercise-induced immune dysfunction, inflammation and oxidative stress [76] . doi = 10.3390/nu8030167 id = cord-287182-f0q8gfzc author = Liao, Ji‐ping title = Severe pneumonia caused by adenovirus 7 in pregnant woman: Case report and review of the literature date = 2016-06-21 keywords = day summary = title: Severe pneumonia caused by adenovirus 7 in pregnant woman: Case report and review of the literature We report a rare case of adenoviral pneumonia in a previously healthy pregnant woman at 26(+4) weeks'' gestation. Here, we report a case of severe communityacquired adenoviral pneumonia in a previously healthy pregnant woman who was managed successfully. 5 Previous studies have shown that pregnant women with viral pneumonia, such as influenza A virus subtype H1N1 and severe acute respiratory syndrome (SARS) coronavirus, have a higher mortality rate and higher rates of both intubation and intensive care unit admission than the general population. 1 In addition, increased adverse pregnancy outcomes, such as preterm delivery, low-birthweight infants, spontaneous abortion and fetal death, are higher in pregnant patients with H1N1 pneumonia than those without. A case-controlled study comparing clinical course and outcomes of pregnant and nonpregnant women with severe acute respiratory syndrome doi = 10.1111/jog.13036 id = cord-318994-1xngjndu author = Lier, Audun J. title = Case Report: Disseminated Strongyloidiasis in a Patient with COVID-19 date = 2020-08-14 keywords = COVID-19; Strongyloides; day summary = We report a case of a COVID-19 patient who developed disseminated strongyloidiasis following treatment with high-dose corticosteroids and tocilizumab. Screening for Strongyloides infection should be pursued in individuals with COVID-19 who originate from endemic regions before initiating immunosuppressive therapy. This report describes the clinical features of a case of disseminated strongyloidiasis infection and polymicrobial bacteremia in an individual who received immunosuppressive treatment for COVID-19. 11 Given our patient''s epidemiologic risk factor and development of Gram-negative bacteremia, the clinical diagnosis of disseminated strongyloidiasis was further supported. The initial Strongyloides serology on hospital day 21 was negative, but the repeat was positive on day 38. 8 This case highlights important considerations when using immunosuppressive therapies for COVID-19 treatment, particularly in patients with risk factors for prior Strongyloides infection. Clinical suspicion for disseminated strongyloidiasis should be maintained in patients from endemic areas who develop Gram-negative sepsis or meningitis. doi = 10.4269/ajtmh.20-0699 id = cord-291315-y40s45iv author = Logunov, Denis Y title = Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia date = 2020-09-04 keywords = SARS; covid-19; day; vaccine summary = title: Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia Primary outcome measures were antigen-specific humoral immunity (SARS-CoV-2-specific antibodies measured by ELISA on days 0, 14, 21, 28, and 42) and safety (number of participants with adverse events monitored throughout the study). INTERPRETATION: The heterologous rAd26 and rAd5 vector-based COVID-19 vaccine has a good safety profile and induced strong humoral and cellular immune responses in participants. These findings of two open, phase 1/2 non-randomised studies of a heterologous prime-boost COVID-19 vaccine based on recombinant adenoviral vectors rAd26-S and rAd5-S show that the vaccine is safe, well tolerated, and induces strong humoral and cellular immune responses in 100% of healthy participants. In our study, despite formation of neutralising antibodies to recombinant adenoviruses after vaccination with rAd26 and rAd5, formation of a humoral immune response to target antigen (SARS-CoV-2 glycoprotein S) in vaccinated volunteers was not affected. doi = 10.1016/s0140-6736(20)31866-3 id = cord-295086-tc3re52f author = Lu, Guoguang title = Dynamic changes in routine blood parameters of a severe COVID-19 case date = 2020-05-13 keywords = day; patient summary = METHODS: We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days. RESULTS: Our study found that the patient''s condition worsened in the first week after admission; white blood cells (WBCs), neutrophils, lymphocytes, monocytes, eosinophils, erythrocytes, hemoglobin, neutrophil lymphocyte ratio (NLR), platelets (PLT) and platelet lymphocyte ratio (PLR) decreased. The number of WBCs, neutrophils, monocytes, eosinophils and lymphocytes increased gradually, and the erythrocyte parameters stopped declining and stabilized in a certain range; CRP decreased rapidly. On the 20th day of admission, the nucleic acid test was negative, WBC, neutrophil, CRP, NLR and PLR decreased gradually, and monocyte, lymphocyte, and eosinophil counts increased. In addition, it should be noted that monocytes and eosinophils were extremely low within 10 days after admission, which might indicate that the patient''s condition was serious, and then gradually recovered to normal. doi = 10.1016/j.cca.2020.04.034 id = cord-314235-08z2jyzd author = Matzinger, P. title = Strong impact of closing schools, closing bars and wearing masks during the Covid-19 pandemic: results from a simple and revealing analysis date = 2020-09-28 keywords = day; figure; rate summary = This change 10 occurred 15 days after schools closed, 12 days after bars and restaurants closed, and one day before the state lockdown, suggesting that the effect of one or both of the first two policy 15 decisions was to reduce the doubling rate of cases to slightly more half of the original rate. Figure 1C shows the effect of the lockdown in MD, which was followed twelve days later by an 25 additional threefold change in doubling time, from 4.7 to 12.8 days, and similar rate reductions in hospitalizations and deaths with additional lags of 2 and 6 days respectively. The results, demonstrate that, other than full lockdowns, three government interventions had the most impact on the rates of Covid-19 infections: closing schools, closing bars and wearing masks. doi = 10.1101/2020.09.26.20202457 id = cord-295367-xhdki8jn author = McNally, D. title = Rapid relief of acute sore throat with AMC/DCBA throat lozenges: randomised controlled trial date = 2009-10-22 keywords = AMC; DCBA; day summary = The superior analgesic effects and improvements in functional impairment scores observed with AMC/DCBA throat lozenges translate into pain relief benefits that are clinically meaningful and are thus a suitable OTC treatment option for patients in the self‐management of acute sore throat. The superior analgesic effects and improvements in functional impairment scores observed with AMC ⁄ DCBA throat lozenges translate into pain relief benefits that are clinically meaningful and are thus a suitable OTC treatment option for patients in the self-management of acute sore throat. The primary objective of this study was to determine the analgesic properties of AMC ⁄ DCBA throat lozenges compared with non-medicated lozenges, in patients with sore throat because of URTIs. The secondary objectives were to determine any additional patient benefits provided by active lozenges compared with placebo lozenges, including the effects on functional impairment scores and the type of relief experienced within the mouth. doi = 10.1111/j.1742-1241.2009.02230.x id = cord-027259-f4sgobcz author = Metsker, Oleg title = Stroke ICU Patient Mortality Day Prediction date = 2020-05-23 keywords = day; mortality; patient; stroke summary = On the basis of the analysis of 12 modern prognostic models from 10 countries we can identify some of the most stable (main) predictors for the causes of intra-hospital mortality: age [16, [20] [21] [22] [23] [24] ; type of stroke [25] ; lesion location [25] ; level of consciousness [11, 20, 23, 25, 26] upon admission; NIHSS stroke severity [10, 21, 22, 24] ; comorbidity [22, 27] , Charlson comorbidity index [23] , Atrial fibrillation [11, 22] , case history Transitor ischemic attack (TIA) [31]; hospital complications (high intracranial pressure) [16] , pneumonia, seizures, anxiety/depression, infections, limb pains and constipation [22, 27] . Early mortality in each subgroup was associated with a number of demographic, clinical, and instrumental-laboratory characteristics based on the interpretation of the results of calculating the significance of predictors of binary classification models by machine learning methods from the Scikit-Learn library 2 . doi = 10.1007/978-3-030-50423-6_29 id = cord-275828-c6d6nk7x author = Mikasa, Keiichi title = JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date = 2016-07-31 keywords = ABPC; BII; Japan; Japanese; MRSA; Respiratory; Society; day; drug; patient; pneumonia; treatment summary = -SBT/ABPC, intravenous drip, 3 g/3e4 times a day -CTRX, intravenous drip, 1 g/twice a day or 2 g/once a day -CTX, intravenous drip, 1e2 g/2e3 times a day -LVFX, intravenous drip, 500 mg/once a day (2) Cases of late-onset hospital-acquired pneumonia or ventilator-associated pneumonia in which the risk of resistant bacteria is high An antimicrobial drug with anti-pseudomonal activity that targets non-glucose-fermentative gram-negative rod should be administered [50, 51, 68] -To treat polymicrobial infection, the administration of an antimicrobial drug with an activity against obligate anaerobe is not always necessary [67, 70] . -SBT/ABPC, intravenous drip, 3 g/3e4 times a day -CTRX, intravenous drip, 2 g/once a day or 1 g/twice a day -CTX, intravenous drip, 1e2 g/2e3 times a day -LVFX, intravenous drip, 500 mg/once a day (2) Late-onset hospital-acquired pneumonia or cases in which there is a risk of multi-drug-resistant bacteria In addition to the above pathogens, the involvement of non-glucose-fermentative gram negative bacteria or ESBLproducing enteric bacteria must be considered. For the treatment of immunodeficiency-/blood disease-related pneumonia in children, antimicrobial drug therapy should also be basically selected, considering causative microorganisms. doi = 10.1016/j.jiac.2015.12.019 id = cord-266156-xmf4emln author = Miller, Tyler E. title = Clinical sensitivity and interpretation of PCR and serological COVID‐19 diagnostics for patients presenting to the hospital date = 2020-08-28 keywords = CoV-2; PCR; SARS; day summary = Our goal was to examine the clinical sensitivity of two most common SARS‐CoV‐2 diagnostic test modalities, polymerase chain reaction (PCR) and serology, over the disease course to provide insight into their clinical interpretation in patients presenting to the hospital. The goal of this study is to examine the clinical sensitivity and provide insights into the interpretation of the two most common SARS-CoV-2 diagnostic test modalities: polymerase chain reaction (PCR) and serology. Serologic analysis of IgM, IgA and IgG status was performed in a subset of the above SARS-CoV-2 PCR-positive patients for which we had excess material in the MGH core laboratories for clinical validation studies. To assess the sensitivity of our serology assay over time, we tested for IgM, IgG, and IgA antibodies against the RBD of SARS-CoV-2 spike protein in 157 SARS-CoV-2 PCR-positive patients using an in-house ELISA (Table 1) . doi = 10.1096/fj.202001700rr id = cord-301947-b6nwaost author = Millán-Oñate, José title = Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin date = 2020-04-24 keywords = COVID-19; SARS; day; patient summary = We report here the clinical features and therapeutic course of the first reported patient with confirmed COVID-19 pneumonia that recovered in Colombia, after the use of chloroquine and clarithromycin. It is essential to acknowledge that no good controlled data are supporting the use of any of these agents, except for a recent randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, that showed no benefit with lopinavir-ritonavir (LPV/RTV) treatment beyond standard care [13] . We present a confirmed case of COVID-19 from Buga, Valle del Cauca, Colombia, that successful recovered of SARS-CoV-2 infection after receiving chloroquine. Although that just based in one case, we cannot recommend the use of these drugs, our patient improved significantly, and his clinical manifestations ceased, including becoming negative for the SARS-CoV-2 infection, as observed in the rRT-PCR test. doi = 10.1186/s12941-020-00358-y id = cord-285096-g9y3au1a author = Mitchell, Judy A. title = Tropism and pathological findings associated with canine respiratory coronavirus (CRCoV) date = 2013-03-23 keywords = CIRD; crcov; day; dog; respiratory summary = Following experimental infection in dogs, all five CRCoV isolates gave rise to clinical signs of respiratory disease consistent with that observed during natural infection. Following experimental infection in dogs, all five CRCoV isolates gave rise to clinical signs of respiratory disease consistent with that observed during natural infection. In that study we demonstrated that young dogs were susceptible to experimental infection with both CRCoV isolates, which gave rise to clinical signs of respiratory disease consistent with naturally occurring infection. Analyses specifically focused on the histopathological changes in the canine upper and lower respiratory tissues, virulence differences among CRCoV isolates derived from CIRD cases representing wide geographical locations; UK and USA [MO, NE, UT and MI] , and the demonstration of Koch''s postulates. Consistent with observations made during naturally occurring infection, dogs in this study also displayed clinical signs of mild respiratory disease following viral challenge (nasal discharge, sneezing, and coughing); whilst the control group remained healthy. doi = 10.1016/j.vetmic.2012.11.025 id = cord-274497-tqceazdp author = N. Nuñez, Luis Fabian title = Molecular Characterization and Pathogenicity of Chicken Parvovirus (ChPV) in Specific Pathogen-Free Chicks Infected Experimentally date = 2020-07-25 keywords = ChPV; day; group summary = In the present work, the pathogenicity, viral tissue distribution and molecular characterization of ChPV in chicks from a strain isolated in Brazil were determined with a demonstration of Koch''s postulates according to our previous description [21] . In the present work, the pathogenicity, viral tissue distribution and molecular characterization of ChPV in chicks from a strain isolated in Brazil were determined with a demonstration of Koch''s postulates according to our previous description [21] . Experimental infections with isolated ChPV (ABU-P1) have demonstrated that the virus causes enteric diseases, resulting mainly in chickens with diarrhea, cloacal pasting, impaired growth, runting and stunting [32] . Lesions were previously described in commercial chicken flocks affected with RSS and reported by our own group [21] ; the duodenal loop presented the same features, demonstrating Koch''s postulates in relation to ChPV and experimentally infected chickens. doi = 10.3390/pathogens9080606 id = cord-337129-6wt6wzxv author = Navas de Solis, Cristobal title = Transient diabetes mellitus in a neonatal Thoroughbred foal date = 2010-10-07 keywords = Day; insulin summary = Objective – To describe the clinical presentation, treatment, and outcome of a neonatal foal diagnosed with transient Type 1 diabetes mellitus. During hospitalization the foal developed hyperglycemia concomitantly with low insulin concentration and an adequate response to exogenous insulin therapy supported a diagnosis of Type 1 diabetes mellitus. On follow up assessment the foal was found to be a healthy euglycemic animal with normal insulin concentration at 11 months of age. Type 1 diabetes mellitus should be considered a differential diagnosis for hyperglycemia in equine neonates and that it can be transient and managed successfully. The insulin concentration in normal foals from birth to 7 days of age is 13.5 AE 1.5 mU/mL. Low insulin concentrations accompanying hyperglycemia and an adequate response to exogenous insulin supports a diagnosis of Type 1 diabetes mellitus. The foal developed complications that resolved with appropriate care and was a healthy animal with normal glycemia and insulin concentration at 11 months of age. doi = 10.1111/j.1476-4431.2010.00588.x id = cord-285812-l7dpv6nx author = O’TOOLE, D. title = Pathogenicity of experimental infection with ‘pneumotropic’ porcine coronavirus date = 1989-07-31 keywords = TGEV; day; piglet summary = Virus localisation and lesions were studied in 14 one-week-old piglets following combined intranasal-oral inoculation with a British isolate of ''pneumotropic'' porcine coronavirus (pcv) and were compared with the effects of transmissible gastroenteritis virus (tgev) infection in five piglets. Virus localisation and lesions were studied in 14 oneweek-old piglets following combined intranasal-oral inoculation with a British isolate of ''pneumotropic'' porcine coronavirus (pcv) and were compared with the effects of transmissible gastroenteritis virus (TGEV) infection in five piglets. Following sterilisation of cages and isolators, a second batch of 12 piglets (Large White cross Landrace) aged seven days from two litters were inoculated with rev (five) or TGEV (five) or were uninoculated controls (two). Between two and six days after infection, acute changes were characterised by individual bronchiolar cells bulging into the lumen, ..; 00I''m Immunocytochemistry r-ev antigen was identified in the epithelial cytoplasm of small and medium bronchioles in eight of 14 piglets and its distribution was closely correlated with areas of pneumonia. doi = 10.1016/s0034-5288(18)31226-8 id = cord-268341-103xf3dw author = Parra, Beatriz title = Kinetics of Cytokine mRNA Expression in the Central Nervous System Following Lethal and Nonlethal Coronavirus-Induced Acute Encephalomyelitis date = 1997-07-07 keywords = CNS; IFN; JHMV; day summary = the plaque size and pathogenesis similar to the parental During JHMV infection of the CNS there is an abrupt suckling mouse brain pool of JHMV originally described increase in mRNA encoding interleukin-1 (a and b), ILby Weiner (1973) and produces a lethal encephalomyeli-6, tumor necrosis factor (TNF)-a, and interferon (IFN)-g, tis with minimal demyelination apparent at the time of at the time of maximal decrease in virus replication and death. Similar of mice through Day 5 postinfection, consistent with the to the kinetics of IFN-g, TNF-a mRNA increased until rapid accumulation of both NK and T cells in the CNS of death of lethally infected mice. Similarly, the adoptive transfer at the time most lethally infected mice were about to succumb to infection (Day 7), there was no difference in the of virus-specific CD4 / T cells to JHMV-infected mice demonstrates that some clones protect via reducing viral peak levels of IL-10 mRNA between the two groups. doi = 10.1006/viro.1997.8613 id = cord-300570-xes201g7 author = Patwardhan, J. title = PREDICTIONS FOR EUROPE FOR THE COVID-19 PANDEMICAFTER LOCKDOWN WAS LIFTED USING AN SIR MODEL date = 2020-10-06 keywords = case; day; model summary = The data is observed to fit the model as predicted until around 150 days after December 31, 2019, after which many countries lift their lockdowns and begin to reopen. An analysis of the residuals is provided to locate the precise date of the departure of each country from its accepted data estimates and test each data point to its predicted value using a Z-test to determine whether each observation can fit the given model. After around Day 170, the model predicts small X2 values with small standards of deviation, so observed residuals at this point mostly represent the growth of the virus itself during that time. Finally, an examination of the date of the first deaths in each country compared to the days until the model began to deviate from its expected behavior yields no relation, indicating that any failure of the observed data points to conform to the model is most likely due to the policy measures taken in each country. doi = 10.1101/2020.10.03.20206359 id = cord-007288-lzxi6q1p author = Pazin, George J. title = Leukocyte Interferon for Treating First Episodes of Genital Herpes in Women date = 1987-12-17 keywords = HSV; day; interferon summary = Women experiencing their first episodes of genital herpes were treated, beginning within three days of the onset of lesions, with 5 × 10(4) units of human leukocyte interferon/kg of body weight for 12 doses over 14 days (total, ∼3.6 × 10(7) units) or with placebo in equivalent volumes. We clinically and virologically assessed the effect of early treatmentwith leukocyte interferon (Cantellvariety) [13] on the initial episode of'' genital herpes.Weindirectly evaluated the effect of .interferon on latency by determining the incidence and frequency of both asymptomatic reactivations and symptomatic recurrences during an intensive one-year follow-up period. Overall, interferon treatment at rv3 x 10 6 U/day had an ameliorative effect on both shedding of virus and the time to healing of initial episodes of genital herpes, but had no significant effect on the associated pain. doi = 10.1093/infdis/156.6.891 id = cord-278224-sq7tokbx author = Protopopova, Alexandra title = Behavioral predictors of subsequent respiratory illness signs in dogs admitted to an animal shelter date = 2019-10-23 keywords = curiosity; day; dog; shelter summary = Therefore, the aim of the study was to explore whether behavior at intake can predict subsequent occurrence and progression of upper respiratory disease in dogs at animal shelters. At the time of the study, the animal shelter had poor disease management practices, including poor sanitation, poor medical care, no vaccination at-intake, overcrowding, and continuous rotation of dogs in the kennels. This short observation period was previously used to detect behavioral differences across kenneled dogs in the animal shelter environment [28, 29] . To evaluate whether the latent temperament variables were associated with health, we proposed a basic structural model in which Curiosity, Sociability, Anxiety, Activity, and Time in the Shelter independently predicted Illness (Fig 1) . To evaluate whether Activity, Sociability, Anxiety, Curiosity, and Time in the shelter were related to the illness score, we conducted a basic PLS Path regression model in which our 5 latent variables were tested for association with illness. doi = 10.1371/journal.pone.0224252 id = cord-266183-uzuda3ir author = Renieris, Georgios title = Serum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Corona virus date = 2020-05-18 keywords = COVID-19; day; h2s summary = In light of these observations suggesting a pivotal role of H2S in the pathogenesis of Covid-19, we studied the serum levels of H2S and its association with final outcome in a cohort of patients with Covid-19 pneumonia. Due to the described anti-inflammatory properties, we hypothesize that elevated levels of H2S in serum are associated with a favourable outcome of Covid-19 pneumonia. Pneumonia Severity Index (PSI) (9); (iii) absolute blood cell counts and biochemistry on admission and follow-up; and 28-day survival. Following ROC curve analysis, it was found that serum levels of H2S on day 1 lower than 150.44μΜ had the best trade-off for sensitivity and specificity for death (Figure 3Aand B ). Forward stepwise Cox regression analysis showed that serum H2S on day 1 above 150.44μM is an independent protective factor for unfavourable outcome of COVID-19 even in the presence of severity scores (Table 1) . doi = 10.1097/shk.0000000000001562 id = cord-271180-cnrs0zpg author = Rizvi, Saniya title = Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? A case report. date = 2020-09-18 keywords = ARDS; cytokine; day; patient summary = CytosorbentsⓇ cytokine filter is a potential treatment methodology aimed at reducing the cytokine storm, thus serving as a bridge for therapy in the acutely ill patients infected with COVID-19. The following case report demonstrates the utility in a critically ill patient who survived the cytokine storm after receiving the cytokine filter via continuous renal replacement therapy bridging him to further definitive therapy. The following is a case report on a patient encounter and management course through the course of illness in which the Cytosorbents Ⓡ filter was used for his presentation of COVID-19 with severe ARDS, worsening renal dysfunction and evidence of evolving cytokine storm. Chest x-ray hospital day 16, 5 days after the initiation of cytokine filter when the patient developed worsening hypoxia and increased oxygen requirements as indicated in Table 2 below. doi = 10.1016/j.hrtlng.2020.09.007 id = cord-319933-yp9ofhi8 author = Ruiz, Sara I. title = Chapter 38 Animal Models of Human Viral Diseases date = 2013-12-31 keywords = Nipah; SARS; animal; clinical; day; disease; experimental; human; infection; model; mouse; virus summary = An experimental study with cell culture-adapted hepatitis Avirus in guinea pigs challenged by oral or intraperitoneal routes did not result in clinical disease, increase in liver enzymes, or seroconversion. 32 NHPs including marmosets, cotton-top tamarins, and rhesus macaques infected with Norwalk virus can be monitored for the extent of viral shedding; however, no clinical disease is observed in these models. 66, 67 Intracerebral and intranasal routes of infection resulted in a fatal disease that was highly dependent on dose, while intradermal and subcutaneous inoculations caused only 50% fatality in mice regardless of the amount of virus. A mouse-adapted (MA) strain of Dengue virus 2 introduced into AG129 mice developed vascular leak syndrome similar to the severe disease seen in humans. [138] [139] [140] [141] [142] [143] [144] Inoculation of WNV into NHPs intracerebrally resulted in the development of either encephalitis, febrile disease, or an asymptomatic infection, depending on the virus strain and dose. doi = 10.1016/b978-0-12-415894-8.00038-5 id = cord-018239-n7axd9bq author = Rusoke-Dierich, Olaf title = Travel Medicine date = 2018-03-13 keywords = Africa; MERS; day; fever; symptom; treatment summary = The following topics should be included in the travel advice consultation: 5 Vaccinations (general and country specific) 5 Country-specific diseases 5 Malaria prophylaxis 5 Mosquito prophylaxis (wearing bright long-sleeved clothes, avoiding perfume, staying in air-conditioned rooms, using a mosquito net, using insect repellents, staying inside at dawn and dusk) 5 Food consumption and drinking overseas (no consumption of ice cubes, uncooked meals, salads and food, which is exposed to flies, limited alcohol consumption) 5 UV protection (using sun cream, avoiding sun exposure between 11.00 and 15.00 o'' clock, remaining in shaded areas, wearing a hat and covering skin) 5 Fitness assessment for travelling, flying and diving 5 Challenges of different climates and their effects on the personal health (dehydration, hyperthermia) 5 Medications 5 Thrombosis counselling 5 Counselling on symptoms on return, which require review (fever, skin changes, abnormal bleeding, lymphadenopathy, diarrhoea) 5 Sexual transmitted diseases 5 Contraception 5 Rabies doi = 10.1007/978-3-319-73836-9_32 id = cord-000705-w52dc97h author = Ríos, Fernando G title = Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic date = 2011-08-17 keywords = H1N1; ICU; NIV; day summary = METHOD: This was a multicenter, prospective inception cohort study including adult patients with acute respiratory failure requiring mechanical ventilation (MV) admitted to 20 ICUs in Argentina between June and September of 2009 during the influenza A (H1N1) pandemic. Although a mild form of the disease was prevalent, it soon became evident that the 2009 influenza A (H1N1) virus could also provoke severe, acute respiratory failure requiring admission to the intensive care unit (ICU) for mechanical ventilation [16] , which was reflected in the severe pathological injury found at autopsy [17] . This was a multicenter, inception cohort study that included patients aged > 15 years admitted to the ICU with a previous history of influenza-like illness, evolving to acute respiratory failure that required mechanical ventilation during the 2009 winter in the Southern Hemisphere. We report on a large, prospective cohort of 2009 influenza A (H1N1) patients that were mechanically ventilated for acute respiratory failure due to diffuse pneumonitis during the pandemic in Argentina. doi = 10.1186/cc10369 id = cord-274860-7ec2jcoq author = Salazar, Eric title = Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG date = 2020-11-04 keywords = covid-19; day; patient summary = title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG We recently reported results from interim analysis of a propensity-score matched study suggesting that early treatment of COVID-19 patients with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG significantly decreases mortality. In the aggregate, the analysis confirms and extends our previous preliminary finding that transfusion of COVID-19 patients soon after hospitalization with high titer anti-spike protein RBD IgG present in convalescent plasma significantly reduces mortality. In our previous study, interim analysis revealed that, relative to matched controls, patients transfused with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG within 72 hrs of hospital admission had significantly reduced mortality at 28 days post-transfusion. The data confirm our previous findings that transfusion of patients soon after hospital admission with high titer anti-spike protein RBD IgG present in convalescent plasma significantly decreases mortality. doi = 10.1016/j.ajpath.2020.10.008 id = cord-271298-7vk3wgw1 author = Sato, Tomoi title = Feeding behavior during sialodacryoadenitis viral infection in rats date = 2001-04-30 keywords = SDA; day; meal summary = This pattern of decreased food intake is similar to that occurring during indomethacin-induced ulcerative ileitis, where we previously measured an increase in plasma tumor-necrosis factor (TNF)-α. The differences in the decrease in the feeding pattern between the SDA viral and a bacterial infection suggest that factors other than TNF-α alone play a significant role in the mechanism of anorexia during a viral infection. An Automated Computerized Rat Eater Meter (ACREM; [7] ), which measures individual meal size and meal number as well as food intake for prolonged periods, provides us with the ability to characterize the biological manifestations associated with feeding behavior including anorexia. Since these cytokines act on the hypothalamus to modulate food intake and feeding behavior, they might have a direct or an indirect influence on the LHA to decrease meal size and on the VMN to inhibit a compensatory increase in meal number during the SDA virus infection. doi = 10.1016/s0031-9384(01)00420-6 id = cord-032240-xswtx940 author = Sauer, François title = Pericardial effusion in patients with COVID-19: case series date = 2020-09-09 keywords = COVID-19; Day summary = Case 1 was a COVID-19 cardiac tamponade without myocarditis, confirmed by a positive chest computed tomography (CT) scan. Case 3 was a cardiac tamponade due to COVID-19 pericarditis, with a positive polymerase chain reaction on pericardial fluid. Since the outbreak of clusters of viral pneumonia due to the novel coronavirus (severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2) in Wuhan, China in December 2019, 1 coronavirus disease 2019 (COVID-19) has spread worldwide infecting more than 5.4 million people and causing more than 349 095 deaths as of 27 May 2020. • Three cases of pericardial effusions (PEs) comprising two tamponades occurred in a single cardiology centre, suggesting a higher cardiac risk than expected during the coronavirus disease 2019 (COVID-19) pandemic. [3] [4] [5] [6] [7] We hereby report a case series of three patients with cardiac and pericardial manifestations of COVID-19 at our institution. Acute myopericarditis with pericardial effusion and cardiac tamponade in a patient with COVID-19 doi = 10.1093/ehjcr/ytaa287 id = cord-030957-45tc5ksf author = Schaap, Andrew title = The politics of precarity date = 2020-08-28 keywords = Apostolidis; Fight; Time; day; politic; precarity; social; work; worker summary = In the final chapters, Apostolidis explores how worker centres might also function synecdochally insofar as the purpose of association is construed not only instrumentally, as protection against the risks associated with precarity, but in terms of their constitutive potential to sustain convivial networks of political possibility for more mutually supportive, creative and pluralistic forms of solidarity than those afforded by traditional unionised spaces. Paul Apostolidis'' book The Fight for Time encapsulates a very similar kind of intellectual-political project as it also seeks to capture the self-understandings of migrant day labourers in their everyday struggles, to reflect on how they resonate with contemporary critical theoretical concepts and to learn how, taken together, these empirical and conceptual insights may lead us to a renewed vision of what a left politics might look like for our age. doi = 10.1057/s41296-020-00435-z id = cord-224211-6lsvjfqb author = Schaback, Robert title = Modelling Recovered Cases and Death Probabilities for the COVID-19 Outbreak date = 2020-03-26 keywords = day summary = title: Modelling Recovered Cases and Death Probabilities for the COVID-19 Outbreak From March 23rd, the data for the recovered cases of COVID-19 are missing from the standard repository maintained by the Johns Hopkins University in collaboration with the WHO. But since data concerning recovered patients are extremely important for modelling the COVID-19 outbreak, a method for estimating the missing data is provided and tested. As a byproduct, it produces estimates for the probabilities to die $k$ days after confirmation, or to survive after $d$ days. The COVID-19 repository [1] at Johns Hopkins University provides cumulative data on • Confirmed infected persons (C) and Authorities only report confirmed cases and deaths, but they say [2] that a person with mild or no symptoms is considered to be recovered after 14 days. This is automatically cumulative and maintains the integrity of person counts between the Confirmed, Deaths, and Recovered. doi = nan id = cord-335490-p63qlcnx author = Schenk, Thomas title = Disseminated Bocavirus Infection after Stem Cell Transplant date = 2007-09-17 keywords = DNA; PRCA; day summary = To the Editor: Human bocavirus (HBoV) (1) is increasingly recognized as a cause of respiratory infections worldwide. Retrospectively, the same NPA sample was reanalyzed for HBoV DNA by real-time PCR (7) and showed a viral load of 4.6 × 10 7 copies/mL (online Appendix Figure) ; specifi city was confi rmed by sequencing. Diarrheic stool samples obtained on day 21 and, after resolution of respiratory symptoms, on day 75 showed substantial HBoV DNA (2.5 × 10 6 and 6.0 × 10 5 copies/mg, respectively; online Appendix Figure) . Drug-induced PRCA is a rare blood disorder in adults and has already been reported in isoniazid-treated patients (3) (4) (5) . This hypothesis is supported by previously reported cases in which PRCA relapses occurred when treatment with isoniazid was resumed (3, 5) . Detection of human bocavirus in Japanese children with lower respiratory tract infections Human bocavirus DNA detected by quantitative real-time PCR in two children hospitalized for lower respiratory tract infection doi = 10.3201/eid1309.070318 id = cord-006344-de4dhv4b author = Seitsonen, E. title = Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection date = 2006-03-21 keywords = POS; day; patient summary = title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection Reported here are two cases of hantavirus pulmonary syndrome caused by Puumala virus infection, which rapidly resolved after initiation of corticosteroid treatment combined with continuous veno-venous hemodiafiltration. We describe two cases of PUU-associated HPS, in which administration of intravenous corticosteroids combined with continuous veno-venous hemodiafiltration (CVVHDF) was followed by rapid clinical improvement. On day 5 POS the lung infiltrates had increased considerably (Fig. 3a,b) , and the patient required continuous ventilation with a positive airway pressure mask. We describe two cases of PUU-infected patients who presented with both renal and respiratory failure requiring renal replacement therapy and mechanical ventilation. High levels of cytokineproducing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome High levels of viremia in patients with the Hantavirus pulmonary syndrome doi = 10.1007/s10096-006-0117-z id = cord-029112-u507i0t0 author = Smith, Keisha title = A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date = 2020-07-13 keywords = ALXN1210-COV-305; Alexion; Amendment; BSC; Investigator; SAE; day; patient; study summary = Study ALXN1210-COV-305 is a multicenter Phase 3, open-label, randomized, controlled study designed to evaluate the safety and efficacy of intravenous (IV) ravulizumab + best supportive care (BSC), compared with BSC alone in patients with a confirmed diagnosis of SARS-CoV-2 infection, and a clinical presentation consistent with COVID-19 severe pneumonia, acute lung injury, or ARDS. doi = 10.1186/s13063-020-04548-z id = cord-014464-m5n250r2 author = Sole-Violan, J title = Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date = 2013-03-19 keywords = AKI; APACHE; ARDS; Care; ICU; IL-6; Introduction; RBC; TBI; day; figure; group; hour; method; mortality; outcome; patient; peep; result; signifi; sofa; study summary = Results In preliminary analysis of categorical data, a signifi cantly (Fisher exact test) greater proportion of patients with compared with without the following fi ndings did not survive; history of alcohol use (P = 0.05); the presence of lethargy (P = 0.01), confusion (P = 0.03), nausea (P = 0.04), abdominal pain (P = 0.02), or the need for vasopressors (P = 0.002), oxygen, mechanical ventilation, or steroids (all P = 0.004) at presentation; and excessive bleeding at surgery (P = 0.01). Methods To prospectively re-evaluate the normal range and to analyze the potential impact of biometric data on ICG-PDR, we measured ICG-PDR (i.v. injection of 0.25 mg/kg ICG; LiMON, Pulsion, Munich, Introduction Mixed venous oxygen saturation (SVO 2 ) represents a well-recognized parameter of oxygen delivery (DO 2 )-consumption (VO 2 ) mismatch and its use has been advocated in critically ill patients in order to guide hemodynamic resuscitation [1] and oxygen delivery optimization. doi = 10.1186/cc11953 id = cord-303878-v2n9jeeb author = Stiles, Jonathan title = Working at home and elsewhere: daily work location, telework, and travel among United States knowledge workers date = 2020-09-05 keywords = day; location; travel; work summary = (2017) used Canadian time use data to explore the relationship of working from different locations with travel, finding that some patterns of working from home were associated with less overall travel, a decreased likelihood of traveling at peak travel times, and an increased likelihood of using a non-motorized form of transport. The third section presents the results from the peak hour travel participation multinomial logistic regression models, and the final section augments this with a survival analysis of initial departure times to shed light on a mechanism of morning peak hour avoidance related to homebased work. When we combine homeworking with other non-workplace locations, such as someone who works at home in the morning and goes to a café to work later in the day, the higher likelihood of avoidance of at least some peak hour work travel remains. doi = 10.1007/s11116-020-10136-6 id = cord-288051-wp8v2mc5 author = Sánchez-González, Álvaro title = What Should Be Known by a Urologist About the Medical Management of COVID-19’s Patients? date = 2020-09-01 keywords = COVID-19; SARS; day; patient summary = Seven days after the clinical onset, the risk of transmission decreases in mildsymptomatic patients, but it may be extended over 24 days in severe cases [11•, 15] . The clinical spectrum of SARS-CoV-2 infection varies widely, including asymptomatic infection, mild upper respiratory tract illness, severe viral pneumonia with respiratory failure, and even death [9, 11•] (Fig. 1) . Corticosteroids are recommended in the treatment of septic shock, exacerbation of chronic obstructive respiratory disease and these COVID-19''s patients with respiratory deterioration and quick radiological progression associated with sings of cytokine storm (cytopenia, maintained fever, an increase of inflammatory reactants: D-dimer > 1000 ng/mL, ferritin > 1000 ng/mL, fibrinogen > 100 ng/mL, IL-6 > 40 pg/mL) [6, 23••] . Results from 237 patients, 158 assigned to remdesivir, showed no differences in time to clinical improvement, 28day mortality, oxygen support, hospitalization, or viral load. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Effective treatment of severe COVID-19 patients with tocilizumab doi = 10.1007/s11934-020-00995-y id = cord-304562-5xh4p786 author = Tanabe, Naoya title = Dupilumab maintenance therapy in an asthmatic patient with coronavirus disease 2019 pneumonia date = 2020-11-07 keywords = day summary = Dupilumab is widely used as an important biologic 33 agent to control severe condition of asthma, eosinophilic chronic rhinosinusitis, 34 and atopic dermatitis. In the pandemic of severe acute respiratory 35 syndrome-coronavirus-2 (SARS-CoV-2) and its associated respiratory disease, clinical course is summarized in Figure 1 . On day12, chest 51 computed tomography (CT) showed bilateral peripheral-dominant ground glass 52 opacity (GGO) and consolidation ( Fig. 2A) , and because he had several risk 53 factors for severe COVID-19 including obesity and diabetes, he was transferred 54 to intensive care unit at our hospital and received oxygen therapy via face mask 55 (5-6 L/min). Then, mepolizumab Dupilumab is an essential biologic agent for severe type of asthma, 84 eosinophilic chronic rhinosinusitis, and atopic dermatitis. Type 2 inflammation modulates ACE2 and TMPRSS2 in airway 155 epithelial cells Asthma 166 exacerbation associated with COVID-19 pneumonia doi = 10.1016/j.alit.2020.10.005 id = cord-007456-acbo4zs2 author = Thomas, L.H. title = Growth of Mycoplasma bovis in organ cultures of bovine foetal trachea and comparison with Mycoplasma dispar date = 2002-11-13 keywords = day summary = authors: Thomas, L.H.; Howard, C.J.; Parsons, K.R.; Anger, H.S. title: Growth of Mycoplasma bovis in organ cultures of bovine foetal trachea and comparison with Mycoplasma dispar Inoculation of tracheal organ cultures from bovine foetuses with Mycoplasma bovis resulted in a loss of cellular structure of the lamina propria, followed 20–22 days later by lifting and detachment of overlying epithelium. Ciliary activity was undiminished for up to 18 days following inoculation and little or no cytopathic effect on the ciliated epithelium was seen in spite of the close proximity of large numbers of organisms. bovis had virtually no cytopathic effect on the ciliated epithelium for 18 days following inoculation in spite of large numbers of organisms infiltrating between the columnar epithelium, accumulating in the lamina propria and amassing in the region of the basement membrane (Fig. 3) . doi = 10.1016/0378-1135(87)90044-7 id = cord-277077-kwaiorp8 author = Tița, Ovidiu title = Use of Yoghurt Enhanced with Volatile Plant Oils Encapsulated in Sodium Alginate to Increase the Human Body’s Immunity in the Present Fight Against Stress date = 2020-10-19 keywords = activity; antioxidant; day; oil; volatile summary = The main purpose of this paper is to create a yoghurt with high antioxidant capacity, using only raw materials from Romania; (2) Methods: The bioactive components used to enrich the cow milk yoghurt were extracted as volatile oils out of four aromatic plants: basil, mint, lavender and fennel. The 2,2-diphenyl-1-picrylhy-drazyl (DPPH) method was used to determine the antioxidant activity; (3) Results: The results show that cow milk yoghurt enhanced with volatile oils of basil, lavender, mint and fennel, encapsulated in sodium alginate has an antioxidant and antimicrobial effect as a staple food with multiple effects in increasing the body''s immunity. The antioxidant and antimicrobial activity of volatile fennel oil is offered by the high content of trans-anethole (63.30%), pinene (11.11%) and fenchone (8.32%) [20] [21] [22] [23] [24] [25] Basil (Ocimum basilicum) is an aromatic plant that belongs to the Lamiaceae family and is considered a rich source of essential oils. doi = 10.3390/ijerph17207588 id = cord-000059-5hwqdnx1 author = Tokars, Jerome I. title = Enhancing Time-Series Detection Algorithms for Automated Biosurveillance date = 2009-04-17 keywords = count; day summary = At a constant alert rate of 1%, sensitivity was improved for both datasets by using a minimum standard deviation (SD) of 1.0, a 14–28 day baseline duration for calculating mean and SD, and an adjustment for total clinic visits as a surrogate denominator. These enhanced methods may increase sensitivity without increasing the alert rate and may improve the ability to detect outbreaks by using automated surveillance system data. For the DoD and hospital ED datasets, sensitivity was improved by using a higher minimum SD of 1.0, a longer baseline duration of 28 days, and adjusting for total visits. Stratifi cation by weekday versus weekend day improves expected value calculations when a substantial day-of-week effect exists, such as in the DoD data. Sensitivity of detecting various numbers of additional counts, by using initial versus best algorithms for hospital emergency department chief complaint data, for selected BioSense data. doi = 10.3201/1504.080616 id = cord-257654-8u9m1k5q author = Tschöpe, Carsten title = Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis date = 2020-07-14 keywords = CVB3; EPL; day summary = On the basis of the link between inflammation, fibrosis, aldosterone, and extracellular matrix regulation, we aimed to investigate the effect of an early intervention with the mineralocorticoid receptor antagonist (MRA) eplerenone on cardiac remodelling in a murine model of persistent coxsackievirus B3 (CVB3)‐induced myocarditis. 40 Because an uncontrolled early fulminant activated immune reaction together with aldosterone can trigger an irreversible cardiac damage with long-time consequences for cardiac remodelling and function in the post-inflammatory myocarditis phase, we sought to demonstrate whether an early intervention with the mineralocorticoid receptor antagonist (MRA) eplerenone (EPL) exerts cardio-beneficial effects to balance the inflammatory defence and healing reaction of the immune system in a murine model of persisting CVB3-induced myocarditis. However, no significant changes in nitrotyrosine staining were detected in any group at 28 days p.i. In vitro, EPL decreased the oxidative stress, depicted as DCF+ cells, in CVB3-infected HL-1 cardiomyocytes ( Figure 5E) . doi = 10.1002/ehf2.12887 id = cord-347716-ka2lm62r author = Usher, Craigan title = Existential Returns date = 2020-06-25 keywords = Day; Phil summary = In light of this and that we are one review short of the intended trio-this due to a child and adolescent psychiatry colleague needing to focus on leadership at her medical center (again, leaning into strengths)-I wished to share with you some thoughts on a favorite film. Groundhog Day tells the story of Pittsburgh meteorologist Phil Connors, who, alongside cameraman Larry, and TV producer Rita travels to Puxatawney, Pennsylvania, to film the annual Groundhog Day celebration. Groundhog Day illustrates many psychodynamic concepts and may speak to those of us whose mental lives are dominated by recurring thoughts of the existential, economic, and emotional hardships of others or questions like if or when schools and hospitals will return to "normal." In addition, the film suggests something that, at first glance, sounds quite odd: that doing the same thing over and over again is not, as some have said, the definition of insanity, but instead an insistence of hope. doi = 10.1016/j.jaac.2020.05.002 id = cord-280821-kc0ut4oy author = Venturini, Elisabetta title = Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease date = 2020-09-24 keywords = COVID-19; Cov-2; SARS; day; patient summary = The Italian Society of Pediatric Infectious Diseases steering and scientific committee developed a position paper on treatment of children with COVID-19, reviewing the current literature on this topic and providing indications based on the available literature data. Currently, American guidelines on COVID-19 treatment published in May 2020, recommend both in children and adults to use lopinavir/ritonavir only in the context of clinical trials, given the lack of effectiveness reported now in literature [9, 12] . The latest Chinese guidelines on SARS-Cov-2 pneumoniae do not recommend the use of a specific antiviral for the treatment of COVID-19, and nevertheless include lopinavir/ritonavir among the available therapeutic options for hospitalized patients [29] . In May 2020, following an assessment of the emergency use authorization criteria and available scientific evidence, the FDA issued an emergency use authorization allowing for the administration of remdesivir intravenously by health care providers for the treatment of COVID-19 suspected or laboratoryconfirmed in adults and pediatric patients hospitalized with severe disease [34] . doi = 10.1186/s13052-020-00900-w id = cord-326143-6ndqgxy8 author = Wang, Qiang title = Successful recovery of severe COVID-19 with cytokine storm treating with extracorporeal blood purification date = 2020-05-26 keywords = day summary = COVID-19 associated cytokine storm could induce ARDS rapidly and the patients would require the support of mechanic ventilation. We present a case of severe SARS-CoV-2 infection who recovered from cytokine storm. The patients with confirmed COVID-19 progressed to acute respiratory distress syndrome (ARDS) rapidly in an incident rate as high as 41.8% 1 , and many of them require mechanic ventilation. Cytokines could be eliminated effectively by extracorporeal blood purification (EBP) 4 , which thus could interrupt the initiation and progression of inflammation cascade in the scenario of COVID-19. IL-6 (198.66 pg/ml) was almost 10 folds of normal range (≤5.9 pg/ml) which indicated an initiation of cytokine storm on day 12 ( Figure 1 ). The patient was largely stable until the chest distress exacerbated and blood in phlegm developed on day 14. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease doi = 10.1016/j.ijid.2020.05.065 id = cord-299343-gsrgf4dd author = Wilson, A. M. title = Quantifying SARS-CoV-2 infection risk within the Apple/Google exposure notification framework to inform quarantine recommendations date = 2020-07-19 keywords = GAEN; day; exposure; quarantine; risk summary = The conditional probability of current or future infectiousness, conditioned on how long post-exposure an exposed individual has been free of symptoms, decreases during quarantine, with shape determined by the distribution of incubation periods, proportion of asymptomatic cases, and distribution of asymptomatic shedding durations. Findings: As an example of our calculations, fifteen minutes of close contact with a high-shedding individual, given a 15% asymptomatic infection rate and no testing, would require 5and 14-day quarantine for their risk of current or future infectiousness to fall below 0.84% and 0.14% risk, respectively. A similarly maximal interaction, i.e. with 30 minutes in each attenuation bin, but with an index case at the minimum Transmission Risk level, corresponding to exposure timing that is not risk-free but falls just outside the window currently used by manual contact tracers, yields an infection probability of 0.36%, requiring 7 days of quarantine. doi = 10.1101/2020.07.17.20156539 id = cord-282158-08u3x1z4 author = Yang, William H. title = Long-term immunogenicity of an AS03-adjuvanted influenza A(H1N1)pdm09 vaccine in young and elderly adults: An observer-blind, randomized trial() date = 2013-09-13 keywords = H1N1; day; vaccine summary = This large-scale, randomized study in subjects ≥18 years of age assessed whether one dose of AS03-adjuvanted 3.75 g HA influenza A(H1N1)pdm09 vaccine elicited immune response that met the US and European regulatory criteria. A single dose of the AS03-adjuvanted 3.75 g HA influenza A(H1N1)pdm09 vaccine elicited HI immune responses in the 18-64 years and >64 years age groups that met the CBER regulatory criteria at Day 21 ( Table 1 ). At Day 21, a single dose of the non-adjuvanted 15 g HA influenza A(H1N1)pdm09 vaccine elicited HI immune responses in subjects 18-64 years and >64 years of age that met the CBER regulatory criteria (Table 1) . Data from this large, controlled study in adults 18 years of age and older demonstrated that a single dose of AS03-adjuvanted or non-adjuvanted influenza A(H1N1)pdm09 vaccine elicited strong HI immune responses 21 days later that met the CHMP and the more stringent CBER criteria for pandemic influenza vaccines. doi = 10.1016/j.vaccine.2013.07.007 id = cord-310249-cvv77f10 author = Yule, Terecita D. title = Canine parvovirus vaccine elicits protection from the inflammatory and clinical consequences of the disease date = 1997-05-31 keywords = CD4; SAA; cell; day summary = In canine parvovirus infected puppies we measured the levels of acute phase proteins and changes in leukocyte phenotypes and cell trafficking by flow cytometry. In this study we evaluated whether measuring levels of acute phase proteins and investigating changes in leukocyte phenotypes by flow cytometry would complement conventional clinical assessment of a vaccine efficacy study. The association of these parameters with the major clinical signs of parvovirus induced disease in vaccinated vs nonvaccinated animals is described for seropositive puppies given a CPV-2 vaccine followed by experimental infection with CPV-2b. Low but significant SAA values were observed in three vaccinates on sporadic days post-challenge, but these values did not coincide with clinical signs, virus shed or hematologic changes. Using cell specific antibodies and flow cytometric analysis, a mean of 88% of leukocytes in peripheral Days Post CPV-2 Challenge blood were positively identified as T-cells (CD4+ and CD@, pan-T), B-cells, monocytes, and neutrophils when compared to the absolute leukocyte count obtained conventionally. doi = 10.1016/s0264-410x(96)00232-0 id = cord-001262-8s7g2wvd author = Zheng, Guoping title = Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study date = 2014-04-04 keywords = ARDS; acute; cell; day; msc summary = title: Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study The objectives of this study were first to examine the possible adverse events after systemic administration of allogeneic adipose-derived MSCs in ARDS patients and second to determine potential efficacy of MSCs on ARDS. METHODS: Twelve adult patients meeting the Berlin definition of acute respiratory distress syndrome with a PaO(2)/FiO(2) ratio of < 200 were randomized to receive allogeneic adipose-derived MSCs or placebo in a 1:1 fashion. Many studies, including publications from our group [11, 12] , have demonstrated compelling evidence of the benefits of MSCs from both bone marrow [13] [14] [15] and adipose tissues [16] [17] [18] in animal models for lung injury and ARDS. In this randomized, placebo-controlled phase I clinical trial, the primary goal was to evaluate the safety and feasibility of systemic administration of allogeneic adipose-derived MSCs in ARDS patients. doi = 10.1186/1465-9921-15-39 id = cord-256015-tt58n0jk author = Zhu, Juanjuan title = Clinical characteristics and therapeutic procedure for a critical case of novel coronavirus pneumonia treated with glucocorticoids and non-invasive ventilator treatment date = 2020-06-01 keywords = NCP; day summary = title: Clinical characteristics and therapeutic procedure for a critical case of novel coronavirus pneumonia treated with glucocorticoids and non-invasive ventilator treatment Herein, we report the clinical characteristics and diagnosis of a patient with severe NCP who was treated with glucocorticoids and non-invasive ventilation. The results indicated that the levels of IL-6 and C-reactive protein had decreased with the increase in the dosage and duration of methylprednisolone therapy and returned to normal on February 10. On the 19 th day of admission, a nasopharyngeal swab was performed for the first time after the treatment and the test result was negative for 2019-nCoV infection. In addition, the levels of IL-6 and C-reactive protein returned to normal on day 8 of methylprednisolone use. Glucocorticoids and non-invasive ventilator treatment could significantly improve the clinical symptoms in critically ill patients with NCP. doi = 10.1590/0037-8682-0227-2020 id = cord-266571-qbskh1uu author = de Arriba, M.L title = Lymphoproliferative responses and protection in conventional piglets inoculated orally with virulent or attenuated porcine epidemic diarrhoea virus date = 2002-06-04 keywords = PEDV; day summary = Lymphocyte proliferative responses were evaluated in mucosal (mesenteric lymph nodes) and systemic (spleen and blood) lymphoid tissues of conventional piglets inoculated with the virulent or attenuated isolates of porcine epidemic diarrhoea virus (PEDV) strain CV-777 and challenged 21 days later with the virulent isolate of the same virus. Virus-specific lymphoproliferative responses of systemic tissues (spleen and blood) and mesenteric lymph nodes were studied in conventional piglets after primary inoculation with the virulent, wild type, strain CV-777 of PEDV or its cell culture attenuated form and after challenge, 3 weeks later, with a high dose of the virulent virus. Correlations between lymphocyte proliferative responses in mononuclear cells collected from mesenteric lymph nodes, blood and spleen from pigs inoculated with virulent or attenuated PEDV or mock-inoculated and protection against challenge 21 days later with virulent PEDV. doi = 10.1016/s0166-0934(02)00063-0 id = cord-034257-kl2ccmz5 author = de Jonge, Jeroen C. title = PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment date = 2020-10-26 keywords = day; patient; stroke summary = title: PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment AIMS AND DESIGN: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke (PRECIOUS) is an international, multi-centre, 3 × 2 factorial, randomised, controlled, open-label clinical trial with blinded outcome assessment, which will assess whether prevention of aspiration, infections, or fever with metoclopramide, ceftriaxone, paracetamol, respectively, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in elderly patients with acute stroke. The primary objective is to assess whether prevention of aspiration, infections, or fever with metoclopramide, ceftriaxone, paracetamol, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in older patients with acute stroke. doi = 10.1186/s13063-020-04717-0 id = cord-005453-4057qib7 author = nan title = The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date = 2019-07-03 keywords = AML; ASCT; ATG; BMT; CD19; CD34; CD4; CD8; CMV; CSF; DFS; DLI; EBMT; EBV; ECP; GVHD; HCT; HLA; HSCT; Hodgkin; Hospital; III; January; MDS; MRD; MSD; NHL; NRM; PBSC; PCR; PFS; PNH; RIC; TBI; TMA; TRM; University; VOD; background; car; cell; conclusion; day; disease; donor; figure; graft; group; high; median; method; mud; patient; result; transplantation summary = To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective, observational cohort study enrolled in 21 HID-SCT and 13 MSD-SCT recipients. The aim of this study is to identify the prognostic impact of pre-transplant TIM3 levels on early and late transplant related complications as well as post-transplant relapse and survival Methods: A total of 177 hematopoietic stem cell transplantation (HSCT) recipients with an initial diagnosis of acute leukemia [median age: 36(16-66) years; male/ female: 111/66] were included in the study. doi = 10.1038/s41409-019-0559-4 id = cord-005460-ezrn8cva author = nan title = Physicians – Poster Session date = 2017-07-28 keywords = AML; ASCT; ATG; BEAM; CD34; CD4; CD8; CMV; CSF; DFS; DLI; Department; EBV; ECP; GVHD; HCT; HLA; HSCT; Hematology; Hodgkin; Hospital; III; January; MDS; MRD; MSC; NHL; NRM; PBSC; PCR; PFS; RIC; SOS; TBI; TRM; Table; University; VOD; cell; day; figure; patient; transplantation summary = Still the optimal combination of immunosuppressive agents with PTCy should be elucidated for different types of SCTs. We report the 2-year update of the prospective NCT02294552 single-center trial that evaluated risk-adapted graft-versushost disease (GVHD) prophylaxis with PTCy in related, unrelated and haploidentical SCTs. 200 adult patients (median age 32 y.o., range: 18-62) with hematologic malignancies, including AML (47.5%), ALL (26.5%), CML (10.5%), MDS (4%), and lymphomas (11.5%), were enrolled in the study. Long-term follow-up from the prospective randomized phase III multicenter trial comparing a standard GvHD prophylaxis with cyclosporine A and methotrexate with or without additional pretransplant ATLG (Grafalon, previously ATG-FRESENIUS S) (given 20 mg/kg/day, days − 3 to − 1) in unrelated donor hematopoietic cell transplantation after myeloablative conditioning resulted in a significant reduction of acute and chronic GvHD without compromising relapse rate and survival [1, 2, 3] . doi = 10.1038/bmt.2017.134 id = cord-005478-5iu38pr6 author = nan title = The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session date = 2019-07-03 keywords = AML; ATG; CMV; EBMT; GVHD; HCT; HLA; HSCT; MRD; NRM; RIC; VOD; background; car; cell; day; figure; patient summary = There were some differences among groups: patients in group-1 were younger (median age 46 years, p< 0.02) were transplanted in more recent year (2015, p< 0.001), received more frequently a regimen based on TBF (thiotepa, fludarabine and busulfan) (83%, p< 0.001) and bone marrow (BM) as source of stem cells (77%, p< 0.001), with no ATG (100%, p< 0.001). Clinical Trial Registry: NCT01217723 Disclosure: None of the Authors have any conflicts of interest to declare O105 Immune reconstitution -based score at diagnosis of CGVHD predicts GVHD severity and overall-survival: A novel prognostication tool for GVHD treatment tailoring Background: Allogeneic stem cell transplantation (HSCT) survivors are at a relevant risk of developing chronic GvHD (cGvHD), which importantly affects quality of life and increases morbidity and mortality. doi = 10.1038/s41409-019-0562-9 id = cord-005497-w81ysjf9 author = nan title = 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date = 2020-03-24 keywords = AKI; AUC; CRP; CRRT; Care; Critical; ECMO; Fig; Hospital; ICU; IQR; Intensive; LOS; LPS; OHCA; PCT; ROC; TBI; Unit; University; VAP; blood; day; figure; group; high; introduction; mortality; patient; result; sepsis; sofa; study; table summary = The positive NC group had more plasma transfusion (p-value 0.03) and a lower median hematocrit at 24 hrs (p-value 0.013), but similar hospital length of stay (p=0.17) and mortality rate (p=0.80) Conclusions: NC at ICU admission identifies subclinical AKI in TBI patients and it maight be used to predictclinical AKI. In patients with pneumonia requiring intensive care (ICU) admission, we hypothesise that abnormal right ventricular (RV) function is associated with an increased 90-day mortality. The objective of this study was to describe the incidence of each AKI stages as defined by KDIGO definition (with evaluation of urine output, serum creatinine and initiation of renal replacement therapy (RRT)), in a mixed medical and surgical population of patients hospitalized in ICU and PCU over a 10-year period (2008-2018). This study aimed at investigating the relationship of goal-directed energy and protein adequacy on clinical outcomes which includes mortality, intensive care unit(ICU) and hospital length of stay (LOS), and length of mechanical ventilation (LOMV). doi = 10.1186/s13054-020-2772-3 id = cord-005646-xhx9pzhj author = nan title = 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date = 1996 keywords = ARDS; CPB; Care; Children; ECMO; Hospital; ICU; Intensive; PICU; Pediatric; Unit; age; blood; case; child; conclusion; day; failure; group; high; hour; increase; infant; level; mean; method; patient; prism; pulmonary; respiratory; result; severe; study; ventilation; year summary = Aims and methods The aim of both a prospective and retrospective survey conducted in German pediatric intensive care units in 1993 was to accumulate data on the epidemiology, risk factors, natural history and treatment strategies in a large group of pediatric ARDS patients who were treated in the tt~ee year period from 1991 to 1993.All patients had acute bilateral alveolar infiltration of noncardiogenic origin and a pO2~iO2 ratio < 150mmHg. The influence of sex, underlying disease and single organ failure was analyzed using the Fischer''s exact test, the influence of additional organ failure on mortality was tested with the Cochran-Mantel-Haenszet statistics. doi = 10.1007/bf02316512 id = cord-005727-li8pwigg author = nan title = ESICM 2010 MONDAY SESSIONS 11 October 2010 date = 2010-08-31 keywords = AKI; APACHE; CRP; Care; GCS; Hospital; ICP; ICU; Intensive; January; LPS; NIV; PCT; Unit; University; VAP; conclusion; day; group; introduction; method; objectives; patient; result; sofa; study summary = Since, continuous epidural analgesia provides the required level of analgesia to support early mobilization and significant reduction in pulmonary and cardiovascular morbidity in the early postoperative period, we postulated that the use of low dose of continuous epidural morphine might improve postoperative analgesia and reduce undesirable side effects in elderly patientsTherefore, the present study was designed to evaluate the effects of morphine administered via epidural patients controlled analgesia and intravenous tramadol + metamizol on postoperative pain control and side effects in elderly patients after major abdominal surgery. For each ventilated patient the following data was registered:Age, APACHE II, the reason of admission, risk factors, use NIV, MV duration, timing of tracheostomy, time of diagnosis of VAP, microbiological data, length of stay and mortality in ICU. 23rd ESICM ANNUAL CONGRESS -BARCELONA, SPAIN -9-13 OCTOBER 2010 S131 Evaluated factors: patient characteristics, signs, symptoms, abscess location, time between symptoms and hospital admission and surgery, lab results, microbiology, antibiotic therapy, APACHE2, SAPS2, SOFA, length of ICU stay, surgical re-intervention, duration of mechanical ventilation, infectious complications, critical illness myopathy (CIM), renal replacement therapy (RRT), re-intubation, tracheotomy, mortality. doi = 10.1007/s00134-010-1999-x id = cord-005777-6rvfsx4p author = nan title = PS 0420-0716 date = 2007-08-25 keywords = APACHE; ARDS; CVVH; Care; GCS; Glasgow; Hospital; ICP; ICU; Intensive; TEG; VAP; conclusion; day; group; mean; method; mortality; patient; peep; result; study summary = We prospectively recorded data of all patients who were newly diagnosed with AF and all those with a septic shock on a surgical ICU (no cardiac surgery) during a one year period according to the requirements of the local ethical committee. Our aim was to evaluate the predictive role of admission APACHE II, admission and total maximum SOFA score, hypoalbuminemia, increased serum creatinine, C-reactive protein, lactate, and serum blood glucose for the 30-day mortality of septic patients admitted to medical ICU. The aim of this study was to analyze the clinical presentation and to evaluate mortality associated factors (timing and accurancy of diagnosis, timing of surgery, severity score and organ failure, surgical and medical treatments). Data were extracted independently to assess intention to treat intensive care unit (ICU) and hospital mortality, days of mechanical ventilation, length of stay, incidence of ventilator-associated pneumonia and pneumothorax, and associated complications of the implemented intervention. doi = 10.1007/s00134-007-0823-8 id = cord-005814-ak5pq312 author = nan title = 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date = 1995 keywords = AMI; APACHE; ARDS; ARF; COPD; CPB; CPR; CVP; Care; ECG; ECMO; Group; H20; Hospital; ICP; ICU; III; IL-6; Intensive; January; LPS; MOF; PSV; SAPS; TNF; Unit; University; acute; blood; cardiac; change; conclusion; control; day; effect; failure; follow; high; hour; increase; level; mean; measure; method; mortality; objective; patient; peep; pressure; pulmonary; respiratory; result; study; treatment; value summary = Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. doi = 10.1007/bf02426401 id = cord-005816-i54q5gsu author = nan title = 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date = 2009-08-06 keywords = Department; GCS; Hospital; ICU; ISS; Istanbul; January; Turkey; University; abdominal; case; conclusion; day; fracture; group; injury; introduction; method; mortality; patient; result; score; study; surgery; trauma; treatment; year summary = Several factors such as the initial lack of symptoms, a low diagnostic sensitivity of the CT (34% false negatives), and the nonoperative management of solid organ injuries, have contributed to a delayed diagnosis in one of every five patients in our series, but this has not led to a significant increase in septic complications in this group. Method: The demographic features, the treatments, the intensity of the illness and mortality rate of the 155 patients in Afyon Kocatepe University General Surgery clinic between the years 2006 Background: Enterocutaneous fistula continues to be a serious surgical problem. Introduction: In our previous study, we examined the treatment results of burn patients older than 45 years, and found a significant increase in mortality with increasing age groups. Methods: Data on emergency surgical cases and admissions to the surgical service over a 3-month period were collected and analyzed; this included patient demographics, referral sources, diagnosis, operation, and length of stay (LOS Conclusion: Emergency workload represents a significant part of the work for the general surgeons. doi = 10.1007/s00068-009-8001-z id = cord-006182-kck5e1ry author = nan title = 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date = 2019-10-01 keywords = AIS; Care; DCI; EEG; EVD; GCS; ICH; ICP; ICU; IQR; January; LOS; MRI; NCC; NIHSS; SAH; SDH; Scale; TBI; TCD; TTM; TXA; day; outcome; patient; stroke; study summary = The primary objective of COGiTATE (CppOpt GuIded Therapy Assessment of Target Effectiveness) is to demonstrate feasibility of individualising CPP at CPPopt in TBI patients, expressed as the percentage of monitoring time for which CPP is within 5 mmHg of regularly updated CPPopt targets during the first 5 days of Intensive Care Unit (ICU) admission. Neurocritical care has become increasingly subspecialized.Yet, due to limited availability of dedicated Neurocritical Care units (NCCUs), often patients may need to be admitted to ICUs other than NCCUs. This survey based study was conducted to explore self-reported knowledge in recognizing and managing some common neurological emergencies such as stroke, status epilepticus, raised intracranial pressure etc among critical care nurses at a Comprehensive Stroke Center. Coagulation factor Xa (recombinant), inactivated-Xa inhibitor associated life--factor prothrombin complex concentrate (PCC) was utilized offRetrospective, single center, cohort study including adult intracranial hemorrhage patients who received discharge between efficacy (defined by International Society on Thrombosis and Haemostasis criteria), thrombotic events, ICU and hospital length of stay, and mortality. doi = 10.1007/s12028-019-00857-7 id = cord-006391-esnsa4u5 author = nan title = Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date = 1982 keywords = AMX; ATP; Doppler; Group; animal; blood; cell; control; day; effect; graft; increase; level; liver; method; normal; patient; rat; result; study summary = In our parallel tests using an excision-sample technique [2] which is considerably more sensitive than the DGHM procedure, we have observed the following mean reductions in the counts of accessible bacteria: iodine in ethanol, 96%; povidone-iodine, 89%; chlorhexidine in ethanol, 88%; iso-propanol, The purpose of this study was to compare radiation injury in Guinea Pig small bowel (1) devoid of contents (2) containing bile (3) containing pancreatic juice. Studies in vitro employing isolated perfused rat pancreas and stomach revealed following results: Mean basal pancreatic somatostatin release in normal, diabetic and transplanted rats were 12___3, 24-t-7, and 17__+4 pg/ml, respectively. As these changes appear closely correlated to the blood glucose levels which show a 30 % decrease at 4 h and progressive restoration towards normal values up to 24 h, attempts have been made to alter the insulin/glucagon ratio by glucose infusion after PH and study its relation to liver regeneration. doi = 10.1007/bf01279099 id = cord-006444-eq56zhtd author = nan title = Abstracts of oral presentations and posters date = 1993 keywords = AML; CD34; CFU; CSF; IFN; IL-1; IL-2; IL-3; IL-4; IL-6; PBPC; SCF; TNF; cell; day; patient summary = The results from ongoing preclinical studies continue to confirm the broad spectrum of biological activities possessed by rhiL-1 1 in vitro and suggest this cytokine may be an effective agent in the treatment of myelosuppression associated with cancer chemotherapy and bone marrow transplantation. We performed a phase H trial to assess the ability of G-CSF -mobilized PBPC to rapidly and completely restore hemopeiesis after high dose chemotherapy in the absence of bone marrow infusions, with selection for PBPC-only infusions based on yield of granulocyte -macrophage colony -forming cells (GM-CFC) after G-CSF treatment. Our approach for high-dose (HD) chemotherapy is to first treat patients eligible for dose intensification with a standard dose chemotherapy (VIP: VP26 = etoposide: 500 mg/m 2, ifosfamide: 4 g/m 2, cis-platinum: 50 mg/m 2) followed by the application of colony stimulating factors (G-CSF, GM-CSF or IL-3 + GM-CSF) in order to combine a regimen with broad anti-tumor activity with the recruitment of peripheral blood progenitor cells (PBPCs). doi = 10.1007/bf01695978 id = cord-006849-vgjz74ts author = nan title = 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date = 2019-09-13 keywords = BMI; December; ERCP; Endosc; GERD; Hospital; ICG; January; Japan; MRI; Medical; Nissen; November; TME; University; aim; approach; cancer; case; complication; conclusion; day; gastric; group; hernia; laparoscopic; method; patient; perform; postoperative; procedure; resection; result; robotic; roux; study; surgery; surgical; time; treatment; year summary = Methods: We are performing this procedures within a prospective randomized trial that is design to compare the long term results of LRYGB-B versus the standard laparoscopic Roux-en-Y gastric bypass.The video shows our technique in a case of a 46 years old female with a BMI of 46 Kg/m2. Material and methods: We present a video of the surgical intervention of a 32-year-old patient, with functional dyspepsia, with a casual diagnosis of a pseudocystic mass of the right colon after performing a CT scan: giant diverticulum of the hepatic colon angle with fecaloid content inside it under tension The patient goes to the emergency room for acute abdominal pain, pending colonoscopy, antibiotic treatment is established, and a laparoscopic approach is decided upon after the patient''s evolution. Method: We present the case of a 65-year-old patient with surgical antecedent of laparoscopic low anterior resection due to rectal cancer, presenting in postoperative period an anastomosis leakage with severe peritonitis was identified and a laparotomy with end colostomy was performed. doi = 10.1007/s00464-019-07109-x id = cord-006856-b1w25ob5 author = nan title = 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date = 2005 keywords = CMV; HBV; HCV; HSCT; PBSC; Patienten; cell; day; die; donor; graft; patient; recipient; transplantation summary = Egr-1 and hypoxia-inducible factor-1 (HIF-1) gene expression was examined in left ventricular biopsies of explanted failing hearts in 28 ICM and 42 DCM patients, as well as in 12 donor grafts before reperfusion (control), at 10, 30, 60 minutes after reperfusion, and at 1, 2, 3, 4, 6, 12 posttransplant weeks, using real-time RT-PCR. The risk of transplant-related mortality (TRM) due to graft-versushost disease (GvHD) is higher in male recipients of female stem cells compared with female patients receiving a graft from a female donor. We therefore analyzed a single-center cohort of 72 high-risk patients transplanted with a related or unrelated stem cell graft after nonmyeloablative conditioning for outcome (acute and chronic GvHD, TRM, relapse, and survival). Four patients between the age of 34 and 44 years underwent allogeneic peripheral blood stem cell (PBSC) transplantation (SCT) from HLA-identical sibling or unrelated donors at our institution. doi = 10.1007/s10353-005-0216-6 id = cord-006870-f5w6fw6q author = nan title = Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting date = 2017-09-19 keywords = AED; CSF; Care; DCI; EEG; EVD; GCS; Glasgow; ICH; ICP; ICU; IQR; January; LOS; MAP; MRI; NCCU; NIHSS; SAH; SDH; SRSE; Scale; TBI; VTE; brain; day; high; outcome; patient; stroke; study; time summary = Subjective perceptions of recovery were assessed via responses to the forced-choice dichotomized question, "Do you feel that you have made a complete recovery from the arrest?"Objective outcome measures of recovery included: Repeatable Battery for Neuropsychological Status (RBANS), Modified Lawton Physical Self-Maintenance Scale (L-ADL), Barthel Index (BI), Cerebral Performance Category Scale (CPC), Center for Epidemiological Studies-Depression scale (CES-D), and Post traumatic stress disorder-checklist (PTSD-C). Utilizing data from the Citicoline Brain Injury Treatment (COBRIT) trial, a prospective multicenter study, we identified 224 patients who met the inclusion criteria; 1) placement of an ICP monitoring device, 2) Glasgow coma score (GCS) less than 9, 3) EVD placement prior to arrival or within 6 hours of arrival at the study institution. The objective of this study was to examine the incidence rates of pre-specified medical and neurological ICU complications, and their impact on post-traumatic in-hospital mortality and 12month functional outcomes. doi = 10.1007/s12028-017-0465-9 id = cord-006876-v2m5l5wz author = nan title = Neurocritical Care Society 14(th) Annual Meeting date = 2016-08-11 keywords = CPP; Care; DCI; EEG; GCS; ICH; ICP; ICU; INR; January; MRI; NIHSS; PCC; SAGE-547; SAH; SRSE; TBI; USA; University; brain; day; outcome; patient; study summary = We conducted a prospective cohort study among mild and moderate-severe TBI patients admitted to a level 1 trauma center with these inclusion criteria: 1) Age < 65 years, 2) No severe non-TBI injuries, 3) No prior cardiac disease, and 4) Minimal comorbidities. In most instances, DC has been performed based on neurosurgical evaluation of the patient with or without intracranial pressure (ICP) monitoring and evidence of increased shown variable outcomes in emergency (within 4 hours of injury) neurosurgical procedure in Traumatic Brain Injury (TBI). This is an observational cohort study of adult patients (>18 years) in a 10-bed NSICU at an academic, tertiary care center evaluating quality outcome measures pre-and post-neurointensivists. Intensivists in neuro ICU must consistently assess and treat the non-neurological complications in traumatic brain and spine-injured patients and deliver appropriate care to bring down the mortality and morbidity and improve outcome. doi = 10.1007/s12028-016-0301-7 id = cord-006880-9dgmdtj8 author = nan title = Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date = 2012-09-19 keywords = CSF; Care; DCI; EEG; GCS; GOS; Glasgow; ICH; ICP; ICU; IQR; IVH; MRI; NIHSS; Neurocritical; SAH; Scale; TBI; TCD; brain; day; outcome; patient; study summary = Patients initially comatose after cardiac arrest treated who awoke after therapeutic hypothermia (TH) were evaluated by a neuropsychologist prior to hospital discharge with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), a well-validated tool that assesses function in multiple domains compared to standardized normal values. Clinical data including the pre-admission-status, neuroradiological, initial presentation, treatment, and outcome were evaluated through institutional databases, patient''s medical charts and by mailed questionnaires. To determine the differences in hospital outcomes among adult mild traumatic brain injury (TBI) patients where the severity of TBI is defined by Glasgow Coma Scale (GCS) score. Retrospective chart analysis was performed on all adult patients arriving to emergency department with history of fall at a level one trauma center for parameters like vomiting, alteration of consciousness (AOC) & loss of consciousness (LOC) after TBI; post-traumatic amnesia (PTA) and history of seizures before or after injury, along with outcomes such as ICU admission & ICU length of stay. doi = 10.1007/s12028-012-9775-0 id = cord-010119-t1x9gknd author = nan title = Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date = 2017-09-04 keywords = ABO; Anti; Background; Blood; CD36; Case; Center; DAT; DTT; Design; FDA; FFP; HBV; HCV; HIV; HLA; Hospital; IPC; MTP; Medical; Medicine; NAT; PCR; PLT; RBC; RHD; Red; Studies; Study; System; TPE; University; WBC; ZIKV; Zika; cd341; cell; conclusion; day; dna; donor; finding; method; patient; platelet; result; sample; table; test; transfusion; type summary = Conclusion: The wide distribution in the concentration of bioactive lipids among 405 stored RBC units suggests that lipid degradation is highly donor-Background/Case Studies: To ensure availability of biological products to hospitals, blood banks have developed and validated multiple storage conditions for each of their products to maximize shelf life and quality. 1 The Department of Blood Transfusion, The PLA General Hospital, 2 The Department of Blood Transfusion, Air Force General Hospital, PLA Background/Case Studies: Recently, multi researches have reported that longer term-stored red blood cells(RBCs) units were associated with increased risks of clinically adverse events, especially in critically ill patients. Weak D types 1, 2 and 3 express all the major RhD epitopes and these patients can be managed as RhD-positive, which may lead to a reduction in unnecessary Rh immunoglobulin (RhIG) administration and conservation of RhD-negative RBCs. Study Design/Method: RHD genotyping was performed on all patient samples with weaker than expected or discrepant RhD typing results, utilizing a commercially available genotyping kit manufactured by Immucor (RHD BeadChip). doi = 10.1111/trf.14286 id = cord-014976-546zaoxn author = nan title = Publication only date = 2006-03-08 keywords = AML; ASCT; ATG; CD34; CSF; GVHD; HLA; HSCT; PBSC; PCR; RIC; SCT; cell; day; patient; stem; transplantation summary = In order to evaluate if malignant and non malignant hematological diseases quantitatively and qualitatively affect BM derived MSCs, bone marrow from children with acute lymphoblastic leukemia (ALL diagnosis n=9, different phases of treatment n=29, end of therapy n=10), idiopathic thrombocytopenic purpura (n=16), autoimmune neutropenia (n=12) and control patients (solid tumors without BM involvement, n=30) was harvested and the mononuclear cell (MNC) fraction isolated. Case: In our hospital a total of 3 patients with relapsed Hodgkin''s disease underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) from an HLA-identical sibling. We report a case of a young male patient of 19 years old with aggressive MS who was treated with a high-dose immunosuppressive regimen (HDIS) using myeloablation followed by autologous blood stem cell transplantation (ASCT) that has induced a dramatic and long-lasting remission of the disease. doi = 10.1038/sj.bmt.1705327 id = cord-015021-pol2qm74 author = nan title = Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date = 1994 keywords = APACHE; ARDS; CD14; CD4; CLP; CRP; CSF; ELISA; ICU; IFN; III; IL-1; IL-2; IL-4; IL-6; IL-8; LEH; LPS; MOF; PAF; PMN; SIRS; TNF; University; animal; blood; cell; control; cytokine; day; effect; endotoxin; factor; follow; group; high; increase; injury; level; method; mouse; patient; production; rat; release; response; result; sepsis; septic; shock; study; trauma summary = It is our current understanding that LPS is responsible for many of the pathophysiological events observed during gramnegative infections and that one of the major mechanisms leading to shock and death is the LPS-induced activation of macrophages resulting in the production and release of lipid and peptide mediators, among which tumor necrosis factor seems to be the most important. However plasma IL-6 estimation revealed a statistically significant reduction at 6 hours in tanrine-treated animals compared to glycino and TW controls ( Objective: To evaluate the effects of allogeneic blood transfusion, thermal injury and bacterial garage on interteukin 4 (IL-4), tumor necrosis factor alpha (TNF) production and host mortality and to study if the administration of thymopentth (THY) could affect these events. doi = 10.1007/bf02258437 id = cord-015024-2xzc0uc5 author = nan title = ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date = 2010-08-31 keywords = APACHE; ARDS; CVP; Care; ECMO; Hospital; ICU; Intensive; conclusion; day; group; high; increase; introduction; level; method; objectives; patient; result; sepsis; sofa; study summary = We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). doi = 10.1007/s00134-010-2001-7 id = cord-015090-n6f4xupw author = nan title = PS 339-563 date = 2005-09-10 keywords = Care; Hospital; ICP; ICU; Intensive; PCT; University; conclusion; day; level; method; patient; study summary = We designed this study to examine the effects of fiberoptic bronchoscopy (FOB) with and without BAL on body temperature, systemic arterial pressure, heart rate and supportive therapies requirements in mechanically ventilated patients. Clinical characteristics (Glasgow scale, heart rate, systolic blood pressure), cardiac enzymes (troponin I, total serum creatine kinase and myocardial isoenzyme, myoglobin), ECG changes (ST-T changes, prolonged QT and corrected QT intervals), echocardiographic assessment of cardiac function (left ventricular ejection fraction, hypokinesia) were studied on the day of the admission. It is a prospective study performed during 12 months of the patients with brain trauma admitted in a 24-beds medical-surgical ICU of a 650-beds university hospital. This prospective observational study included 200 adult patients admitted to a 31-bed university hospital medical-surgical ICU during a 3-month period. doi = 10.1007/s00134-005-2780-4 id = cord-015126-cyhcbk1j author = nan title = PS 0036-0344 date = 2007-08-25 keywords = APACHE; ARDS; Care; HFOV; Hospital; ICU; Intensive; PCT; VAP; blood; conclusion; day; group; increase; introduction; method; mortality; patient; peep; pressure; result; sofa; study summary = We compared them with ≥70 years old and an ICU stay < 30 days patients, the differences in ICU mortality, Apache II, age, gender and the necessity for renal replacement therapy (RRT) were not significant (see table) . The patients with mild form of acute pancreatitis had low mortality rate (similar to general ward population) despite positive ICU admission criteria in our case series with fifty per cent development of severe form with organ dysfunction/failure later on. Collected data:Demographics,Management prior and during ICU hospitalization (sedation, catecolamin drug use, blood product transfusion, intra-cranial pressure monitoring, neurosurgical emergency surgery etc.),CT-Scan results, Daily worst Glasgow coma scale, admission Simplified Acute Physiology Score II. This prospective interventional study performed in a surgical Intensive Care Unit of a tertiary University Hospital included 35 (21 males) mechanically ventilated and sedated patients with acute cardiovascular failure requiring cardiac output measurement (transpulmonary thermodilution technique)and a fluid challenge. doi = 10.1007/s00134-007-0820-y id = cord-015369-72cjogxz author = nan title = 50th Annual Meeting of the Austrian Society of Surgery. Vienna, June 18–20, 2009. Guest Editors: Albert Tuchmann, Erhard Schwanzer, Benedikt Walzel date = 2009 keywords = Abteilung; BMI; Background; Behandlung; CLE; Chemotherapie; Ergebnisse; Fällen; GERD; Grundlagen; Gruppe; Jahren; Komplikationen; Operation; PGD; Patienten; Rahmen; Studie; Therapie; V.A.C.; auf; bei; case; conclusion; day; der; des; die; eine; follow; ist; method; mit; nach; patient; result; sich; surgery; treatment; tumor; von; werden; wurde; year summary = Bei 2 Patienten wurde wegen eines Rezidivs eine neuerliche RFT mit liver packing notwendig, 5 Patienten wurden ohne Packing ein zweites mal abladiert und ein Patient unterzog sich einer linksseitigen Hemihepatektomie nach rechtsseitiger Ablation. Das laparoskopische Liver Packing ermöglicht eine ablative Therapie der Leber in Patienten, die mit den herkömmlichen Möglichkeiten nicht lokal therapierbar sind. Zusammenfassend lässt sich anhand der hier vorliegenden Studie zeigen, dass die Therapie von VSM mittels ELT mit 1470-nm-Diodenlaser und Radialfaser eine sowohl minimalinvasive als auch sichere und effiziente Therapieoption darstellt und eine hohe frühzeitige Erfolgsrate bei niedrigem Schmerzniveau aufweist.In weiteren Studien muss geprueft werden, ob aehnlich gute Resultate auch bei weiterer Absenkung des Energienivaus zu erreichen sind. Patients who underwent R0 resection for colon and rectal cancer during the period 1995-2000 showed a significantly improved 5-year survival rate compared to those operated on between 1991 and 1995. doi = 10.1007/s10353-009-0461-1 id = cord-015389-vwgai4k9 author = nan title = Publication only date = 2009-03-25 keywords = AML; CD34; CMV; CSF; GVHD; HLA; HSCT; cell; day; median; patient summary = This study evaluates the safety of this approach, in terms of infusion-related toxicity and hematopoietic reconstitution, in 385 consecutive autologous transplantations performed from 4/97 to 9/08 in 348 patients (median age 46; underlying disease: lymphoma in 178, myeloma in 131, acute leukaemia in 17, breast cancer in 22). Patients and methods: Eight pts after allogeneic hematopoetic stem cell transplantation (HSCT) underwent MSCs infusions (median age of pts was 11 years, male/female: 6/2) between 2006 and 2009. Akiyama Tokyo Metropolitan Komagome Hospital (Tokyo, JP) Acute graft-versus-host disease (GVHD) is one of the major factors that have infl uence on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). Material and methods: during a 8 years period we have performed 144 stem cells transplantation in 134 patients with different hematological malignancies(AML: 74; ALL: 6; CML: 7; CLL: 1, NHL: 13; Hodgkin Diseases: 16; Multiple myelomas: 24; Aplastic anaemia: 1;Myelofi brosis:1 Ewing Sarcoma: 1; Male:78 Female 66. doi = 10.1038/bmt.2009.50 id = cord-022659-chwk2bs4 author = nan title = Abstracts: Poster session date = 2004-10-08 keywords = ALS; Alzheimer; Association; CNS; CSF; GBS; HTLV; MBP; MRI; Neurological; Parkinson; age; cell; control; day; disease; patient; study; test summary = We investigated the usefulness of informant-based data in Alzheimer''s disease (AD) by comparing caregivers'' subjective evaluations of 83 probable A D patients'' performance on an abbreviated version of the Memory Self-Report Questionnaire to objective evaluations derived from an extensive battery of neuropsychological tests and to clinicians'' evaluations. Compared with 89 subjects (mean age 75.2 yr; 34 men, 55 women) with dementia of the Alzheimer type (DAT), there were no significant group differences for comparable Clinical Dementia Rating stages of dementia for measures of language, Activities of Daily Living, or general cognition. The mean age at onset did not differ significantly between handedness groups (F [ l,lOO] = .82), but the mean duration of symptoms ( Alterations in the optical properties of brain can be used to detect pathological changes in patients with Alzheimer''s disease (AD). doi = 10.1002/ana.410320224 id = cord-023017-k6edtg58 author = nan title = AASLD Abstracts (pp. 282A–382A) date = 2006-02-10 keywords = CD4; CD8; HCC; HCV; HIV; HSC; IFN; MELD; OLT; PCR; RNA; SVR; alt; cell; conclusion; day; group; liver; method; patient; result; study summary = 14/55 (25%) patients in AC who did not discontinue by week 24 received ribavirin dose reduction in comparison to 31/108 ( The clinical outcome in response to combination therapy for treatment of chronic hepatitis C virus (HCV) infection appears to be different for Caucasian versus African American patients. Over the period of combination therapy, most patients in which serum virus titers were reduced to non detectable levels had significant increases in T cell responses to HCV proteins. CHRONIC Background: Recent large prospective trials demonstrated that the combination therapy of interferon (1FN)-alphalribavirin significantly increased the ratio of a sustained virological response in patients with chronic hepatitis C in comparison with IFN monotherapy, especially in patients with high HCV-RNA titer and genotype lb. Results: Patients with chronic HCV infection showed higher MxA gene expression levels than healthy controls, indicating that hepatitis C virus induces IFN production. doi = 10.1002/hep.1840380505 id = cord-023095-4dannjjm author = nan title = Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011 date = 2011-05-03 keywords = ACTH; CHF; CKCS; CKD; DMVD; ECG; ELISA; IBD; PCR; TLR5; University; Veterinary; blood; cat; concentration; day; disease; dna; dog; group; horse; sample; study; test; time; treatment summary = The purpose of this study was to determine the short-term effects of ivabradine on heart rate (HR), blood pressure, left ventricular (LV) systolic and diastolic function, left atrial (LA) performance, and clinical tolerance in healthy cats after repeated oral doses. The goal of this study was to investigate the relationship between heart rate and ECG time intervals to body mass in apparently healthy horses and ponies and to calculate normal ranges for different weight groups. This study aimed to investigate the prevalence of hypercoagulability in PLN dogs based on thromboelastography (TEG), and to determine whether hypercoagulability in these patients could be predicted by clinical assessments that identify systemic hypertension (systolic blood pressure 4 160 mmHg), hypoalbuminemia (serum albumin o 2.7 mg/dl), antithrombin activity (o 70%), and degree of proteinuria (urine protein:creatinine ratio [UPC] ! doi = 10.1111/j.1939-1676.2011.0726.x id = cord-023100-0pqnsiid author = nan title = Abstract date = 2008-04-10 keywords = day summary = key: cord-023100-0pqnsiid authors: nan cord_uid: 0pqnsiid nan The dogs had mild diarrhoea from three to 11 days after inoculation, approximately at the same time as the virus was excreted in the faeces. Virus could be isolated from the tonsils on day 3, and then from small and large intestinal tissues up to 14 days after inoculation; it was also isolated from liver and lung tissue. Virus neutralising antibody was first detected on day 10. Specific anti-ccv IgM was first detected in plasma three days after inoculation and IgG on days 4 to 7. Small amounts of anti-ccv IgG, IgM and IgA were detected in duodenal secretions, but none in bile. Chronic relapsing (dysimmune) polyneuropathy: diagnosis and treatment Chronic relapsing polyradiculoneuritis in a cat Peripheral neuropathy in cats with inherited primary hyperchylomicronaemia The authors wish to thank Karen Wadewell and Denise Wigney for expert technical assistance, and Dr A. doi = 10.1111/j.1748-5827.1991.tb00876.x id = cord-335975-m6lkrehi author = nan title = Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date = 2018-02-05 keywords = AKI; ARDS; CKD; December; ECMO; Fig; ICU; IQR; January; NIV; SAPS; VAP; care; day; group; introduction; mortality; patient; result; sofa; study summary = A qSOFA score relying on 3 simple clinical criteria (respiratory rate, mental status and systolic blood pressure) has been proposed to better identify septic patients with associated higher mortality outside the intensive care unit (Seymour CW et al., JAMA 2016) . We propose to determine whether the arterial oxygen pressure (PaO2) at intensive care unit (ICU) admission affects mortality at day 28 (D28) in patients with septic shock subjected to mechanical out-of-hospital ventilation. Conclusion: In this study, we report a significant association between hyperoxemia at ICU admission and mortality at D28 in patients with septic shock subjected to pre-hospital invasive mechanical ventilation. The aim of this study was to describe outcome of pediatric patient with hematologic disease hospitalized in our intensive care unit for respiratory failure and to investigate the clinical variables associated with mortality. doi = 10.1186/s13613-017-0345-7 id = cord-341063-3rqnu5bu author = nan title = 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date = 2018-03-29 keywords = AKI; APACHE; ARDS; Care; Critical; Fig; Hospital; ICU; IQR; IVC; Intensive; LOS; TBI; University; VAP; conclusion; day; group; high; introduction; method; mortality; patient; peep; result; score; sofa; study; table summary = Procacitonin (PCT) emerges as a possible predictive tool in cardiothoracic intensive care unit (CTICU).We aim at testing the predictive power of PCT for early morbidity, prolonged ventilation, ICU and hospital stay, in patients developing early fever after cardiac surgery Methods: A retrospective descriptive study done in tertiary cardiac center, enrolling patients who stayed for more than 24 hours post-operatively in the CTICU Risk stratification included additive Euro score and PCT immunoluminometricaly prior to surgery and every 48 hours in response to onset of fever. Prognostic accuracy of quick sequential organ failure assessment (qSOFA) score for mortality: systematic review and meta-analysis Introduction: The purpose of this study was to summarize the evidence assessing the qSOFA [1] , calculated in admission of the patient in emergency department (ED) or intensive care unit (ICU), as a predictor of mortality. doi = 10.1186/s13054-018-1973-5 id = cord-355038-o2hr5mox author = nan title = Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date = 2020-02-11 keywords = AKI; ARDS; CHU; COPD; Care; Correspondence; December; ECMO; Fig; France; Hospital; ICU; IQR; January; NIV; PICU; VAP; day; french; group; high; invitation; method; mortality; patient; rationale; result; sofa; study summary = doi = 10.1186/s13613-020-0623-7 id = cord-317347-by8albr9 author = van Ginkel, Frederik W. title = Age-dependent immune responses and immune protection after avian coronavirus vaccination date = 2015-05-28 keywords = Fig; IBV; day; group summary = The delayed and/or lower antibody response combined with lower IgG avidity indices coincided with increased tracheal inflammation and depletion of tracheal epithelia cells and goblet cells upon IBV field strain challenge. Therefore, the ability of SPF chickens of different age to induce an IBV-specific antibody response and protect against challenge with an IBV field strain was measured. In order to measure IgG (IgY), IgA and IgM antibody levels in plasma and tears of chicken, an IBV-specific enzyme-linked immunosorbent assay (ELISA) was developed as previously described [20] . These data are consistent with a delay in the IgA plasma response to IBV in birds vaccinated at a younger age and a non-significant decline in mean IgA titers in the 1-day-old group. This would be consistent with a drop of presumably natural maternal IBV-specific IgM antibodies in these SPF chickens in the day 7 control age group. doi = 10.1016/j.vaccine.2015.04.026 id = cord-001192-zbogocki author = van Meer, Maurits PA title = Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report date = 2014-01-30 keywords = CHMI; day; myocarditis summary = A 23-year-old healthy male volunteer took part in a clinical trial in which the volunteer took chloroquine chemoprophylaxis and received three intradermal doses at four-week intervals of aseptic, purified Plasmodium falciparum sporozoites to induce protective immunity against malaria. Here, a very probable case of acute myocarditis is described in a volunteer who had taken chloroquine chemoprophylaxis, was inoculated three times at fourweek intervals with PfSPZ Challenge, received six travelrelated routine vaccines after this immunization procedure, had CHMI by the bites of five PfSPZ-infected mosquitoes 8.5 weeks after the last dose of PfSPZ Challenge and 4.5 weeks after the last dose of chloroquine, had a sore throat on day 9 after CHMI, developed P. Fatal myocarditis in course of Plasmodium falciparum infection: case report and review of cardiac complications in malaria Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report doi = 10.1186/1475-2875-13-38