key: cord-292970-32mql9nq
authors: Camdessanche, Jean-Philippe; Morel, Jérôme; Pozzetto, Bruno; Paul, Stéphane; Tholance, Yannick; Botelho-Nevers, Elisabeth
title: COVID-19 may induce Guillain-Barré syndrome
date: 2020-04-15
journal: Rev Neurol (Paris)
DOI: 10.1016/j.neurol.2020.04.003
sha: 
doc_id: 292970
cord_uid: 32mql9nq

nan

A 64-year-old man without medical history was admitted to our hospital after he fell and hurt his left shoulder leading to a tear of the rotator cuff. He had fever and cough for two days. In the context of COVID-19 pandemic, SARS-CoV-2 RT-PCR on nasopharyngeal swab was performed and positive. Clinical presentation was moderate with high grade fever for three days requiring oxygen 2-3 L/min through nasal cannula for five days. He received paracetamol, preventing thromboembolism by low molecular weight heparin and lopinavir/ritonavir 400/100 mg twice a day for ten days. Thoracic CT scan showed only 10-25% of ground glass opacities.

Eleven days after the symptom onset, while he did not need oxygen anymore having had no fever for five days, the patient complained of paresthesia in feet and hands. In three days, he Covid-19 pandemic is a worldwide disaster. Pulmonary disorder and respiratory insufficiency are the main problems linked to SARS-CoV-2 infection, which explains difficulties in ICU to treat numerous patients [2] . Recently, Zhao et al. questioned the link between COVID-19 and GBS [3] . Our case is the first GBS with a chronology undoubtedly in favor of a complication of COVID-19 infection. This must be known by clinicians as GBS may lead to ICU admission and needs to be differentiated from a possible ICU-acquired weakness after ICU treatments. 

Diagnosis of Guillain-Barré syndrome and validation of Brighton criteria

Clinical Characteristics of Coronavirus Disease 2019 in China

Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence?