id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285262-690kpupt	Imre, Gergely	The involvement of regulated cell death forms in modulating the bacterial and viral pathogenesis	2020-01-27		.txt	text/plain	13203	714	38	Apoptosis, necroptosis and pyroptosis represent three distinct types of regulated cell death forms, which play significant roles in response to viral and bacterial infections. Abstract Apoptosis, necroptosis and pyroptosis represent three distinct types of regulated cell death forms, which play significant roles in response to viral and bacterial infections. In this chapter, based on the current advances in the research, we give a detailed description about the key cell death modalities, including apoptosis, necroptosis and pyroptosis emerging in response to pathogenic insults, and we discuss how bacterial and viral infections can modulate these signaling pathways. The components of the bacterial T3SS trigger inflammasome formation and pyroptotic cell death in Shigella infected macrophages through the activation of the NLR family CARD domain containing protein 4 (NLRC4) (Fig. 3) . Macrophage activation redirects yersinia-infected host cell death from apoptosis to caspase-1-dependent pyroptosis	./cache/cord-285262-690kpupt.txt	./txt/cord-285262-690kpupt.txt