id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334773-yw2qgv13	Lisco, Giuseppe	Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review	2020-08-10		.txt	text/plain	7901	359	32	This concern has been further confirmed by the results of a cohort study among 85 fatal cases of COVID-19 in Wuhan, hence defining DM as a potentially harmful comorbidity predisposing to worse clinical course or death once SARS-CoV-2 infection occurred [49] . Different hypothesis should be considered for explaining this clinical phenomenon, including glucose control at baseline and during the infection course, pathophysiology and immune system response in SARS-CoV-2 infected patients with T2D, diabetes-related comorbidities and concomitant medications. In conclusion, diabetic patients especially elderly individuals and those with worse baseline glucose control may exhibit immune system dysregulation that predispose them to a less effective response against SARS-CoV-2 and to a dysfunctional inflammation that requires to be carefully monitored in confirmed cases of COVID-19, for preventing or avoiding a harmful progression of the disease. Immune response and systemic inflammation play a crucial role in SARS-CoV-2 infection, particularly in case of severe clinical course of the disease.	./cache/cord-334773-yw2qgv13.txt	./txt/cord-334773-yw2qgv13.txt