id sid tid token lemma pos cord-350182-s10nong7 1 1 key key NNP cord-350182-s10nong7 1 2 : : : cord-350182-s10nong7 1 3 cord-350182-s10nong7 cord-350182-s10nong7 NN cord-350182-s10nong7 1 4 authors author NNS cord-350182-s10nong7 1 5 : : : cord-350182-s10nong7 1 6 Milionis Milionis NNP cord-350182-s10nong7 1 7 , , , cord-350182-s10nong7 1 8 Charalampos Charalampos NNP cord-350182-s10nong7 1 9 ; ; : cord-350182-s10nong7 1 10 Milioni Milioni NNP cord-350182-s10nong7 1 11 , , , cord-350182-s10nong7 1 12 Stella Stella NNP cord-350182-s10nong7 1 13 Olga Olga NNP cord-350182-s10nong7 2 1 title title NN cord-350182-s10nong7 2 2 : : : cord-350182-s10nong7 2 3 A a DT cord-350182-s10nong7 2 4 brief brief JJ cord-350182-s10nong7 2 5 analysis analysis NN cord-350182-s10nong7 2 6 and and CC cord-350182-s10nong7 2 7 hypotheses hypothesis NNS cord-350182-s10nong7 2 8 about about IN cord-350182-s10nong7 2 9 the the DT cord-350182-s10nong7 2 10 risk risk NN cord-350182-s10nong7 2 11 of of IN cord-350182-s10nong7 2 12 COVID-19 COVID-19 NNP cord-350182-s10nong7 2 13 for for IN cord-350182-s10nong7 2 14 people people NNS cord-350182-s10nong7 2 15 with with IN cord-350182-s10nong7 2 16 type type NN cord-350182-s10nong7 2 17 1 1 CD cord-350182-s10nong7 2 18 and and CC cord-350182-s10nong7 2 19 type type NN cord-350182-s10nong7 2 20 2 2 CD cord-350182-s10nong7 2 21 diabetes diabetes NN cord-350182-s10nong7 2 22 mellitus mellitus NN cord-350182-s10nong7 2 23 date date NN cord-350182-s10nong7 2 24 : : : cord-350182-s10nong7 2 25 2020 2020 CD cord-350182-s10nong7 2 26 - - HYPH cord-350182-s10nong7 2 27 07 07 CD cord-350182-s10nong7 2 28 - - HYPH cord-350182-s10nong7 2 29 20 20 CD cord-350182-s10nong7 2 30 journal journal NN cord-350182-s10nong7 2 31 : : : cord-350182-s10nong7 2 32 J J NNP cord-350182-s10nong7 2 33 Diabetes diabetes NN cord-350182-s10nong7 2 34 Metab Metab NNP cord-350182-s10nong7 2 35 Disord Disord NNP cord-350182-s10nong7 2 36 DOI doi NN cord-350182-s10nong7 2 37 : : : cord-350182-s10nong7 2 38 10.1007 10.1007 CD cord-350182-s10nong7 2 39 / / SYM cord-350182-s10nong7 2 40 s40200 s40200 NN cord-350182-s10nong7 2 41 - - HYPH cord-350182-s10nong7 2 42 020 020 CD cord-350182-s10nong7 2 43 - - HYPH cord-350182-s10nong7 2 44 00592 00592 CD cord-350182-s10nong7 2 45 - - SYM cord-350182-s10nong7 2 46 3 3 CD cord-350182-s10nong7 2 47 sha sha NNP cord-350182-s10nong7 2 48 : : : cord-350182-s10nong7 2 49 1a267b4c89606d2b62aa6340f23f39c3145351ef 1a267b4c89606d2b62aa6340f23f39c3145351ef CD cord-350182-s10nong7 2 50 doc_id doc_id CD cord-350182-s10nong7 2 51 : : : cord-350182-s10nong7 2 52 350182 350182 CD cord-350182-s10nong7 2 53 cord_uid cord_uid NNS cord-350182-s10nong7 2 54 : : : cord-350182-s10nong7 2 55 s10nong7 s10nong7 NNP cord-350182-s10nong7 3 1 COVID-19 COVID-19 NNP cord-350182-s10nong7 3 2 is be VBZ cord-350182-s10nong7 3 3 an an DT cord-350182-s10nong7 3 4 infectious infectious JJ cord-350182-s10nong7 3 5 respiratory respiratory JJ cord-350182-s10nong7 3 6 disease disease NN cord-350182-s10nong7 3 7 which which WDT cord-350182-s10nong7 3 8 firstly firstly RB cord-350182-s10nong7 3 9 occurred occur VBD cord-350182-s10nong7 3 10 in in IN cord-350182-s10nong7 3 11 Wuhan Wuhan NNP cord-350182-s10nong7 3 12 , , , cord-350182-s10nong7 3 13 China China NNP cord-350182-s10nong7 3 14 and and CC cord-350182-s10nong7 3 15 evolved evolve VBD cord-350182-s10nong7 3 16 rapidly rapidly RB cord-350182-s10nong7 3 17 around around IN cord-350182-s10nong7 3 18 the the DT cord-350182-s10nong7 3 19 globe globe NN cord-350182-s10nong7 3 20 . . . cord-350182-s10nong7 4 1 The the DT cord-350182-s10nong7 4 2 causative causative JJ cord-350182-s10nong7 4 3 pathogen pathogen NN cord-350182-s10nong7 4 4 is be VBZ cord-350182-s10nong7 4 5 a a DT cord-350182-s10nong7 4 6 novel novel JJ cord-350182-s10nong7 4 7 coronavirus coronavirus NN cord-350182-s10nong7 4 8 called call VBN cord-350182-s10nong7 4 9 SARS SARS NNP cord-350182-s10nong7 4 10 - - HYPH cord-350182-s10nong7 4 11 CoV-2 CoV-2 NNP cord-350182-s10nong7 4 12 with with IN cord-350182-s10nong7 4 13 genomic genomic JJ cord-350182-s10nong7 4 14 similarities similarity NNS cord-350182-s10nong7 4 15 with with IN cord-350182-s10nong7 4 16 SARS SARS NNP cord-350182-s10nong7 4 17 - - HYPH cord-350182-s10nong7 4 18 CoV CoV NNP cord-350182-s10nong7 4 19 and and CC cord-350182-s10nong7 4 20 MERS- MERS- NNP cord-350182-s10nong7 5 1 CoV. CoV. NNP cord-350182-s10nong7 6 1 The the DT cord-350182-s10nong7 6 2 disease disease NN cord-350182-s10nong7 6 3 is be VBZ cord-350182-s10nong7 6 4 transmitted transmit VBN cord-350182-s10nong7 6 5 among among IN cord-350182-s10nong7 6 6 humans human NNS cord-350182-s10nong7 6 7 either either CC cord-350182-s10nong7 6 8 through through IN cord-350182-s10nong7 6 9 direct direct JJ cord-350182-s10nong7 6 10 contact contact NN cord-350182-s10nong7 6 11 or or CC cord-350182-s10nong7 6 12 via via IN cord-350182-s10nong7 6 13 droplets droplet NNS cord-350182-s10nong7 6 14 from from IN cord-350182-s10nong7 6 15 sneeze sneeze NN cord-350182-s10nong7 6 16 or or CC cord-350182-s10nong7 6 17 cough cough NN cord-350182-s10nong7 6 18 . . . cord-350182-s10nong7 7 1 Most Most JJS cord-350182-s10nong7 7 2 infected infected JJ cord-350182-s10nong7 7 3 persons person NNS cord-350182-s10nong7 7 4 remain remain VBP cord-350182-s10nong7 7 5 asymptomatic asymptomatic JJ cord-350182-s10nong7 7 6 or or CC cord-350182-s10nong7 7 7 mildly mildly RB cord-350182-s10nong7 7 8 symptomatic symptomatic JJ cord-350182-s10nong7 7 9 , , , cord-350182-s10nong7 7 10 but but CC cord-350182-s10nong7 7 11 some some DT cord-350182-s10nong7 7 12 patients patient NNS cord-350182-s10nong7 7 13 may may MD cord-350182-s10nong7 7 14 develop develop VB cord-350182-s10nong7 7 15 severe severe JJ cord-350182-s10nong7 7 16 clinical clinical JJ cord-350182-s10nong7 7 17 features feature NNS cord-350182-s10nong7 7 18 , , , cord-350182-s10nong7 7 19 including include VBG cord-350182-s10nong7 7 20 pneumonia pneumonia NN cord-350182-s10nong7 7 21 , , , cord-350182-s10nong7 7 22 respiratory respiratory JJ cord-350182-s10nong7 7 23 failure failure NN cord-350182-s10nong7 7 24 , , , cord-350182-s10nong7 7 25 sepsis sepsis NN cord-350182-s10nong7 7 26 and and CC cord-350182-s10nong7 7 27 even even RB cord-350182-s10nong7 7 28 death death NN cord-350182-s10nong7 7 29 . . . cord-350182-s10nong7 8 1 People People NNS cord-350182-s10nong7 8 2 of of IN cord-350182-s10nong7 8 3 advanced advanced JJ cord-350182-s10nong7 8 4 age age NN cord-350182-s10nong7 8 5 and/or and/or CC cord-350182-s10nong7 8 6 with with IN cord-350182-s10nong7 8 7 underlying underlie VBG cord-350182-s10nong7 8 8 diseases disease NNS cord-350182-s10nong7 8 9 ( ( -LRB- cord-350182-s10nong7 8 10 including include VBG cord-350182-s10nong7 8 11 diabetes diabetes NN cord-350182-s10nong7 8 12 mellitus mellitus NN cord-350182-s10nong7 8 13 ) ) -RRB- cord-350182-s10nong7 8 14 are be VBP cord-350182-s10nong7 8 15 at at IN cord-350182-s10nong7 8 16 greater great JJR cord-350182-s10nong7 8 17 risk risk NN cord-350182-s10nong7 8 18 . . . cord-350182-s10nong7 9 1 The the DT cord-350182-s10nong7 9 2 innate innate JJ cord-350182-s10nong7 9 3 and and CC cord-350182-s10nong7 9 4 adaptive adaptive JJ cord-350182-s10nong7 9 5 immune immune JJ cord-350182-s10nong7 9 6 system system NN cord-350182-s10nong7 9 7 are be VBP cord-350182-s10nong7 9 8 responsible responsible JJ cord-350182-s10nong7 9 9 for for IN cord-350182-s10nong7 9 10 protecting protect VBG cord-350182-s10nong7 9 11 the the DT cord-350182-s10nong7 9 12 body body NN cord-350182-s10nong7 9 13 against against IN cord-350182-s10nong7 9 14 viral viral JJ cord-350182-s10nong7 9 15 infection infection NN cord-350182-s10nong7 9 16 . . . cord-350182-s10nong7 10 1 Nevertheless nevertheless RB cord-350182-s10nong7 10 2 , , , cord-350182-s10nong7 10 3 it -PRON- PRP cord-350182-s10nong7 10 4 is be VBZ cord-350182-s10nong7 10 5 assumed assume VBN cord-350182-s10nong7 10 6 that that IN cord-350182-s10nong7 10 7 SARS SARS NNP cord-350182-s10nong7 10 8 - - HYPH cord-350182-s10nong7 10 9 CoV-2 CoV-2 NNP cord-350182-s10nong7 10 10 interferes interfere VBZ cord-350182-s10nong7 10 11 with with IN cord-350182-s10nong7 10 12 the the DT cord-350182-s10nong7 10 13 immune immune JJ cord-350182-s10nong7 10 14 system system NN cord-350182-s10nong7 10 15 through through IN cord-350182-s10nong7 10 16 immunomodulating immunomodulating JJ cord-350182-s10nong7 10 17 mechanisms mechanism NNS cord-350182-s10nong7 10 18 which which WDT cord-350182-s10nong7 10 19 intensify intensify VBP cord-350182-s10nong7 10 20 its -PRON- PRP$ cord-350182-s10nong7 10 21 pathogenesis pathogenesis NN cord-350182-s10nong7 10 22 . . . cord-350182-s10nong7 11 1 A a DT cord-350182-s10nong7 11 2 delayed delayed JJ cord-350182-s10nong7 11 3 or or CC cord-350182-s10nong7 11 4 reduced reduce VBN cord-350182-s10nong7 11 5 response response NN cord-350182-s10nong7 11 6 of of IN cord-350182-s10nong7 11 7 the the DT cord-350182-s10nong7 11 8 innate innate JJ cord-350182-s10nong7 11 9 immune immune JJ cord-350182-s10nong7 11 10 system system NN cord-350182-s10nong7 11 11 is be VBZ cord-350182-s10nong7 11 12 critical critical JJ cord-350182-s10nong7 11 13 for for IN cord-350182-s10nong7 11 14 the the DT cord-350182-s10nong7 11 15 development development NN cord-350182-s10nong7 11 16 of of IN cord-350182-s10nong7 11 17 pathogenesis pathogenesis NN cord-350182-s10nong7 11 18 of of IN cord-350182-s10nong7 11 19 the the DT cord-350182-s10nong7 11 20 virus virus NN cord-350182-s10nong7 11 21 . . . cord-350182-s10nong7 12 1 People People NNS cord-350182-s10nong7 12 2 with with IN cord-350182-s10nong7 12 3 diabetes diabete NNS cord-350182-s10nong7 12 4 are be VBP cord-350182-s10nong7 12 5 more more RBR cord-350182-s10nong7 12 6 likely likely JJ cord-350182-s10nong7 12 7 to to TO cord-350182-s10nong7 12 8 develop develop VB cord-350182-s10nong7 12 9 severe severe JJ cord-350182-s10nong7 12 10 symptoms symptom NNS cord-350182-s10nong7 12 11 of of IN cord-350182-s10nong7 12 12 COVID-19 COVID-19 NNP cord-350182-s10nong7 12 13 . . . cord-350182-s10nong7 13 1 The the DT cord-350182-s10nong7 13 2 present present JJ cord-350182-s10nong7 13 3 article article NN cord-350182-s10nong7 13 4 speculates speculate VBZ cord-350182-s10nong7 13 5 that that IN cord-350182-s10nong7 13 6 special special JJ cord-350182-s10nong7 13 7 aspects aspect NNS cord-350182-s10nong7 13 8 of of IN cord-350182-s10nong7 13 9 the the DT cord-350182-s10nong7 13 10 immune immune JJ cord-350182-s10nong7 13 11 dysfunction dysfunction NN cord-350182-s10nong7 13 12 caused cause VBN cord-350182-s10nong7 13 13 by by IN cord-350182-s10nong7 13 14 chronic chronic JJ cord-350182-s10nong7 13 15 hyperglycaemia hyperglycaemia NN cord-350182-s10nong7 13 16 is be VBZ cord-350182-s10nong7 13 17 the the DT cord-350182-s10nong7 13 18 main main JJ cord-350182-s10nong7 13 19 reason reason NN cord-350182-s10nong7 13 20 for for IN cord-350182-s10nong7 13 21 this this DT cord-350182-s10nong7 13 22 susceptibility susceptibility NN cord-350182-s10nong7 13 23 . . . cord-350182-s10nong7 14 1 Coronavirus Coronavirus NNP cord-350182-s10nong7 14 2 disease disease NN cord-350182-s10nong7 14 3 2019 2019 CD cord-350182-s10nong7 14 4 ( ( -LRB- cord-350182-s10nong7 14 5 COVID-19 COVID-19 NNP cord-350182-s10nong7 14 6 ) ) -RRB- cord-350182-s10nong7 14 7 is be VBZ cord-350182-s10nong7 14 8 a a DT cord-350182-s10nong7 14 9 respiratory respiratory JJ cord-350182-s10nong7 14 10 infection infection NN cord-350182-s10nong7 14 11 which which WDT cord-350182-s10nong7 14 12 is be VBZ cord-350182-s10nong7 14 13 caused cause VBN cord-350182-s10nong7 14 14 by by IN cord-350182-s10nong7 14 15 a a DT cord-350182-s10nong7 14 16 novel novel JJ cord-350182-s10nong7 14 17 virus virus NN cord-350182-s10nong7 14 18 belonging belong VBG cord-350182-s10nong7 14 19 to to IN cord-350182-s10nong7 14 20 the the DT cord-350182-s10nong7 14 21 Coronaviridae Coronaviridae NNP cord-350182-s10nong7 14 22 family family NN cord-350182-s10nong7 14 23 [ [ -LRB- cord-350182-s10nong7 14 24 1 1 CD cord-350182-s10nong7 14 25 ] ] -RRB- cord-350182-s10nong7 14 26 and and CC cord-350182-s10nong7 14 27 is be VBZ cord-350182-s10nong7 14 28 officially officially RB cord-350182-s10nong7 14 29 named name VBN cord-350182-s10nong7 14 30 SARS SARS NNP cord-350182-s10nong7 14 31 - - HYPH cord-350182-s10nong7 14 32 CoV-2 CoV-2 NNP cord-350182-s10nong7 14 33 ( ( -LRB- cord-350182-s10nong7 14 34 severe severe JJ cord-350182-s10nong7 14 35 acute acute JJ cord-350182-s10nong7 14 36 respiratory respiratory JJ cord-350182-s10nong7 14 37 syndrome syndrome NN cord-350182-s10nong7 14 38 coronavirus coronavirus NN cord-350182-s10nong7 14 39 2 2 CD cord-350182-s10nong7 14 40 ) ) -RRB- cord-350182-s10nong7 14 41 . . . cord-350182-s10nong7 15 1 In in IN cord-350182-s10nong7 15 2 humans human NNS cord-350182-s10nong7 15 3 , , , cord-350182-s10nong7 15 4 coronaviruses coronaviruse NNS cord-350182-s10nong7 15 5 primarily primarily RB cord-350182-s10nong7 15 6 target target VBP cord-350182-s10nong7 15 7 the the DT cord-350182-s10nong7 15 8 respiratory respiratory JJ cord-350182-s10nong7 15 9 system system NN cord-350182-s10nong7 15 10 and and CC cord-350182-s10nong7 15 11 have have VBP cord-350182-s10nong7 15 12 also also RB cord-350182-s10nong7 15 13 caused cause VBN cord-350182-s10nong7 15 14 outbreaks outbreak NNS cord-350182-s10nong7 15 15 of of IN cord-350182-s10nong7 15 16 respiratory respiratory JJ cord-350182-s10nong7 15 17 disease disease NN cord-350182-s10nong7 15 18 in in IN cord-350182-s10nong7 15 19 the the DT cord-350182-s10nong7 15 20 past past NN cord-350182-s10nong7 15 21 , , , cord-350182-s10nong7 15 22 mainly mainly RB cord-350182-s10nong7 15 23 the the DT cord-350182-s10nong7 15 24 severe severe JJ cord-350182-s10nong7 15 25 acute acute JJ cord-350182-s10nong7 15 26 respiratory respiratory JJ cord-350182-s10nong7 15 27 syndrome syndrome NN cord-350182-s10nong7 15 28 ( ( -LRB- cord-350182-s10nong7 15 29 SARS SARS NNP cord-350182-s10nong7 15 30 - - HYPH cord-350182-s10nong7 15 31 CoV CoV NNP cord-350182-s10nong7 15 32 ) ) -RRB- cord-350182-s10nong7 15 33 in in IN cord-350182-s10nong7 15 34 2003 2003 CD cord-350182-s10nong7 15 35 and and CC cord-350182-s10nong7 15 36 the the DT cord-350182-s10nong7 15 37 Middle Middle NNP cord-350182-s10nong7 15 38 East East NNP cord-350182-s10nong7 15 39 respiratory respiratory JJ cord-350182-s10nong7 15 40 syndrome syndrome NN cord-350182-s10nong7 15 41 ( ( -LRB- cord-350182-s10nong7 15 42 MERS MERS NNP cord-350182-s10nong7 15 43 - - HYPH cord-350182-s10nong7 15 44 CoV CoV NNP cord-350182-s10nong7 15 45 ) ) -RRB- cord-350182-s10nong7 15 46 in in IN cord-350182-s10nong7 15 47 2012 2012 CD cord-350182-s10nong7 15 48 . . . cord-350182-s10nong7 16 1 They -PRON- PRP cord-350182-s10nong7 16 2 are be VBP cord-350182-s10nong7 16 3 a a DT cord-350182-s10nong7 16 4 large large JJ cord-350182-s10nong7 16 5 family family NN cord-350182-s10nong7 16 6 of of IN cord-350182-s10nong7 16 7 positivesense positivesense NN cord-350182-s10nong7 16 8 single single RB cord-350182-s10nong7 16 9 - - HYPH cord-350182-s10nong7 16 10 stranded strand VBN cord-350182-s10nong7 16 11 RNA RNA NNP cord-350182-s10nong7 16 12 viruses virus NNS cord-350182-s10nong7 16 13 ( ( -LRB- cord-350182-s10nong7 16 14 + + CC cord-350182-s10nong7 16 15 ssRNA ssRNA -RRB- cord-350182-s10nong7 16 16 ) ) -RRB- cord-350182-s10nong7 16 17 with with IN cord-350182-s10nong7 16 18 a a DT cord-350182-s10nong7 16 19 crownlike crownlike JJ cord-350182-s10nong7 16 20 appearance appearance NN cord-350182-s10nong7 16 21 under under IN cord-350182-s10nong7 16 22 the the DT cord-350182-s10nong7 16 23 electron electron NN cord-350182-s10nong7 16 24 microscope microscope NN cord-350182-s10nong7 16 25 due due IN cord-350182-s10nong7 16 26 to to IN cord-350182-s10nong7 16 27 the the DT cord-350182-s10nong7 16 28 presence presence NN cord-350182-s10nong7 16 29 of of IN cord-350182-s10nong7 16 30 spike spike NN cord-350182-s10nong7 16 31 glycoproteins glycoprotein NNS cord-350182-s10nong7 16 32 on on IN cord-350182-s10nong7 16 33 the the DT cord-350182-s10nong7 16 34 envelope envelope NN cord-350182-s10nong7 16 35 [ [ -LRB- cord-350182-s10nong7 16 36 2 2 CD cord-350182-s10nong7 16 37 ] ] -RRB- cord-350182-s10nong7 16 38 . . . cord-350182-s10nong7 17 1 These these DT cord-350182-s10nong7 17 2 viruses virus NNS cord-350182-s10nong7 17 3 derive derive VBP cord-350182-s10nong7 17 4 from from IN cord-350182-s10nong7 17 5 animal animal NN cord-350182-s10nong7 17 6 species specie NNS cord-350182-s10nong7 17 7 ( ( -LRB- cord-350182-s10nong7 17 8 bats bat NNS cord-350182-s10nong7 17 9 , , , cord-350182-s10nong7 17 10 rodents rodent NNS cord-350182-s10nong7 17 11 , , , cord-350182-s10nong7 17 12 birds bird NNS cord-350182-s10nong7 17 13 ) ) -RRB- cord-350182-s10nong7 17 14 and and CC cord-350182-s10nong7 17 15 can can MD cord-350182-s10nong7 17 16 cross cross VB cord-350182-s10nong7 17 17 barriers barrier NNS cord-350182-s10nong7 17 18 between between IN cord-350182-s10nong7 17 19 species specie NNS cord-350182-s10nong7 17 20 , , , cord-350182-s10nong7 17 21 also also RB cord-350182-s10nong7 17 22 infecting infect VBG cord-350182-s10nong7 17 23 humans human NNS cord-350182-s10nong7 17 24 [ [ -LRB- cord-350182-s10nong7 17 25 3 3 CD cord-350182-s10nong7 17 26 ] ] -RRB- cord-350182-s10nong7 17 27 . . . cord-350182-s10nong7 18 1 The the DT cord-350182-s10nong7 18 2 transmission transmission NN cord-350182-s10nong7 18 3 of of IN cord-350182-s10nong7 18 4 SARS SARS NNP cord-350182-s10nong7 18 5 - - HYPH cord-350182-s10nong7 18 6 CoV-2 CoV-2 NNP cord-350182-s10nong7 18 7 among among IN cord-350182-s10nong7 18 8 humans human NNS cord-350182-s10nong7 18 9 occurs occur VBZ cord-350182-s10nong7 18 10 mainly mainly RB cord-350182-s10nong7 18 11 through through IN cord-350182-s10nong7 18 12 direct direct JJ cord-350182-s10nong7 18 13 contact contact NN cord-350182-s10nong7 18 14 or or CC cord-350182-s10nong7 18 15 droplets droplet NNS cord-350182-s10nong7 18 16 spread spread VBN cord-350182-s10nong7 18 17 by by IN cord-350182-s10nong7 18 18 coughing cough VBG cord-350182-s10nong7 18 19 or or CC cord-350182-s10nong7 18 20 sneezing sneeze VBG cord-350182-s10nong7 18 21 from from IN cord-350182-s10nong7 18 22 an an DT cord-350182-s10nong7 18 23 infected infected JJ cord-350182-s10nong7 18 24 individual individual NN cord-350182-s10nong7 18 25 [ [ -LRB- cord-350182-s10nong7 18 26 4 4 CD cord-350182-s10nong7 18 27 ] ] -RRB- cord-350182-s10nong7 18 28 . . . cord-350182-s10nong7 19 1 The the DT cord-350182-s10nong7 19 2 incubation incubation NN cord-350182-s10nong7 19 3 period period NN cord-350182-s10nong7 19 4 in in IN cord-350182-s10nong7 19 5 most most JJS cord-350182-s10nong7 19 6 individuals individual NNS cord-350182-s10nong7 19 7 varies vary VBZ cord-350182-s10nong7 19 8 between between IN cord-350182-s10nong7 19 9 2 2 CD cord-350182-s10nong7 19 10 and and CC cord-350182-s10nong7 19 11 14 14 CD cord-350182-s10nong7 19 12 days day NNS cord-350182-s10nong7 19 13 [ [ -LRB- cord-350182-s10nong7 19 14 5 5 CD cord-350182-s10nong7 19 15 ] ] -RRB- cord-350182-s10nong7 19 16 . . . cord-350182-s10nong7 20 1 On on IN cord-350182-s10nong7 20 2 average average JJ cord-350182-s10nong7 20 3 , , , cord-350182-s10nong7 20 4 each each DT cord-350182-s10nong7 20 5 person person NN cord-350182-s10nong7 20 6 has have VBZ cord-350182-s10nong7 20 7 the the DT cord-350182-s10nong7 20 8 potential potential NN cord-350182-s10nong7 20 9 to to TO cord-350182-s10nong7 20 10 spread spread VB cord-350182-s10nong7 20 11 the the DT cord-350182-s10nong7 20 12 infection infection NN cord-350182-s10nong7 20 13 to to IN cord-350182-s10nong7 20 14 2.2 2.2 CD cord-350182-s10nong7 20 15 - - SYM cord-350182-s10nong7 20 16 2.7 2.7 CD cord-350182-s10nong7 20 17 other other JJ cord-350182-s10nong7 20 18 people people NNS cord-350182-s10nong7 20 19 [ [ -LRB- cord-350182-s10nong7 20 20 6 6 CD cord-350182-s10nong7 20 21 ] ] -RRB- cord-350182-s10nong7 20 22 . . . cord-350182-s10nong7 21 1 The the DT cord-350182-s10nong7 21 2 majority majority NN cord-350182-s10nong7 21 3 of of IN cord-350182-s10nong7 21 4 infected infected JJ cord-350182-s10nong7 21 5 individuals individual NNS cord-350182-s10nong7 21 6 ( ( -LRB- cord-350182-s10nong7 21 7 about about RB cord-350182-s10nong7 21 8 80 80 CD cord-350182-s10nong7 21 9 % % NN cord-350182-s10nong7 21 10 ) ) -RRB- cord-350182-s10nong7 21 11 remains remain VBZ cord-350182-s10nong7 21 12 asymptomatic asymptomatic JJ cord-350182-s10nong7 21 13 or or CC cord-350182-s10nong7 21 14 with with IN cord-350182-s10nong7 21 15 mild mild JJ cord-350182-s10nong7 21 16 symptoms symptom NNS cord-350182-s10nong7 21 17 , , , cord-350182-s10nong7 21 18 whilst whilst IN cord-350182-s10nong7 21 19 the the DT cord-350182-s10nong7 21 20 remainder remainder NN cord-350182-s10nong7 21 21 suffer suffer VBP cord-350182-s10nong7 21 22 from from IN cord-350182-s10nong7 21 23 severe severe JJ cord-350182-s10nong7 21 24 or or CC cord-350182-s10nong7 21 25 critical critical JJ cord-350182-s10nong7 21 26 clinical clinical JJ cord-350182-s10nong7 21 27 features feature NNS cord-350182-s10nong7 21 28 . . . cord-350182-s10nong7 22 1 The the DT cord-350182-s10nong7 22 2 most most RBS cord-350182-s10nong7 22 3 common common JJ cord-350182-s10nong7 22 4 symptoms symptom NNS cord-350182-s10nong7 22 5 of of IN cord-350182-s10nong7 22 6 COVID-19 covid-19 DT cord-350182-s10nong7 22 7 include include VBP cord-350182-s10nong7 22 8 fever fever NN cord-350182-s10nong7 22 9 , , , cord-350182-s10nong7 22 10 cough cough NN cord-350182-s10nong7 22 11 , , , cord-350182-s10nong7 22 12 sore sore JJ cord-350182-s10nong7 22 13 throat throat NN cord-350182-s10nong7 22 14 , , , cord-350182-s10nong7 22 15 malaise malaise NN cord-350182-s10nong7 22 16 and and CC cord-350182-s10nong7 22 17 dyspnoea dyspnoea NNS cord-350182-s10nong7 22 18 . . . cord-350182-s10nong7 23 1 In in IN cord-350182-s10nong7 23 2 severe severe JJ cord-350182-s10nong7 23 3 cases case NNS cord-350182-s10nong7 23 4 , , , cord-350182-s10nong7 23 5 patients patient NNS cord-350182-s10nong7 23 6 may may MD cord-350182-s10nong7 23 7 develop develop VB cord-350182-s10nong7 23 8 pneumonia pneumonia NN cord-350182-s10nong7 23 9 , , , cord-350182-s10nong7 23 10 acute acute JJ cord-350182-s10nong7 23 11 respiratory respiratory JJ cord-350182-s10nong7 23 12 distress distress NN cord-350182-s10nong7 23 13 syndrome syndrome NN cord-350182-s10nong7 23 14 , , , cord-350182-s10nong7 23 15 respiratory respiratory JJ cord-350182-s10nong7 23 16 failure failure NN cord-350182-s10nong7 23 17 , , , cord-350182-s10nong7 23 18 septic septic JJ cord-350182-s10nong7 23 19 shock shock NN cord-350182-s10nong7 23 20 and and CC cord-350182-s10nong7 23 21 multi multi JJ cord-350182-s10nong7 23 22 - - JJ cord-350182-s10nong7 23 23 organ organ JJ cord-350182-s10nong7 23 24 failure failure NN cord-350182-s10nong7 23 25 which which WDT cord-350182-s10nong7 23 26 can can MD cord-350182-s10nong7 23 27 lead lead VB cord-350182-s10nong7 23 28 to to IN cord-350182-s10nong7 23 29 death death NN cord-350182-s10nong7 23 30 [ [ -LRB- cord-350182-s10nong7 23 31 7 7 CD cord-350182-s10nong7 23 32 ] ] -RRB- cord-350182-s10nong7 23 33 . . . cord-350182-s10nong7 24 1 The the DT cord-350182-s10nong7 24 2 elderly elderly JJ cord-350182-s10nong7 24 3 and and CC cord-350182-s10nong7 24 4 those those DT cord-350182-s10nong7 24 5 with with IN cord-350182-s10nong7 24 6 underlying underlie VBG cord-350182-s10nong7 24 7 diseases disease NNS cord-350182-s10nong7 24 8 ( ( -LRB- cord-350182-s10nong7 24 9 such such JJ cord-350182-s10nong7 24 10 as as IN cord-350182-s10nong7 24 11 hypertension hypertension NN cord-350182-s10nong7 24 12 , , , cord-350182-s10nong7 24 13 cardiovascular cardiovascular JJ cord-350182-s10nong7 24 14 diseases disease NNS cord-350182-s10nong7 24 15 , , , cord-350182-s10nong7 24 16 diabetes diabete VBZ cord-350182-s10nong7 24 17 mellitus mellitus NN cord-350182-s10nong7 24 18 and and CC cord-350182-s10nong7 24 19 chronic chronic JJ cord-350182-s10nong7 24 20 pulmonary pulmonary JJ cord-350182-s10nong7 24 21 diseases disease NNS cord-350182-s10nong7 24 22 ) ) -RRB- cord-350182-s10nong7 24 23 are be VBP cord-350182-s10nong7 24 24 more more JJR cord-350182-s10nong7 24 25 at at IN cord-350182-s10nong7 24 26 risk risk NN cord-350182-s10nong7 24 27 of of IN cord-350182-s10nong7 24 28 adverse adverse JJ cord-350182-s10nong7 24 29 outcomes outcome NNS cord-350182-s10nong7 24 30 [ [ -LRB- cord-350182-s10nong7 24 31 8 8 CD cord-350182-s10nong7 24 32 ] ] -RRB- cord-350182-s10nong7 24 33 . . . cord-350182-s10nong7 25 1 The the DT cord-350182-s10nong7 25 2 first first JJ cord-350182-s10nong7 25 3 cases case NNS cord-350182-s10nong7 25 4 of of IN cord-350182-s10nong7 25 5 COVID-19 COVID-19 , cord-350182-s10nong7 25 6 were be VBD cord-350182-s10nong7 25 7 detected detect VBN cord-350182-s10nong7 25 8 in in IN cord-350182-s10nong7 25 9 Wuhan Wuhan NNP cord-350182-s10nong7 25 10 , , , cord-350182-s10nong7 25 11 the the DT cord-350182-s10nong7 25 12 largest large JJS cord-350182-s10nong7 25 13 metropolitan metropolitan JJ cord-350182-s10nong7 25 14 area area NN cord-350182-s10nong7 25 15 in in IN cord-350182-s10nong7 25 16 Hubei Hubei NNP cord-350182-s10nong7 25 17 province province NN cord-350182-s10nong7 25 18 , , , cord-350182-s10nong7 25 19 China China NNP cord-350182-s10nong7 25 20 . . . cord-350182-s10nong7 26 1 The the DT cord-350182-s10nong7 26 2 spread spread NN cord-350182-s10nong7 26 3 of of IN cord-350182-s10nong7 26 4 the the DT cord-350182-s10nong7 26 5 disease disease NN cord-350182-s10nong7 26 6 evolved evolve VBD cord-350182-s10nong7 26 7 quickly quickly RB cord-350182-s10nong7 26 8 to to IN cord-350182-s10nong7 26 9 a a DT cord-350182-s10nong7 26 10 pandemic pandemic NN cord-350182-s10nong7 26 11 . . . cord-350182-s10nong7 27 1 As as IN cord-350182-s10nong7 27 2 of of IN cord-350182-s10nong7 27 3 June June NNP cord-350182-s10nong7 27 4 29 29 CD cord-350182-s10nong7 27 5 , , , cord-350182-s10nong7 27 6 2020 2020 CD cord-350182-s10nong7 27 7 , , , cord-350182-s10nong7 27 8 the the DT cord-350182-s10nong7 27 9 number number NN cord-350182-s10nong7 27 10 of of IN cord-350182-s10nong7 27 11 COVID-19 covid-19 JJ cord-350182-s10nong7 27 12 infections infection NNS cord-350182-s10nong7 27 13 globally globally RB cord-350182-s10nong7 27 14 has have VBZ cord-350182-s10nong7 27 15 exceeded exceed VBN cord-350182-s10nong7 27 16 10 10 CD cord-350182-s10nong7 27 17 million million CD cord-350182-s10nong7 27 18 cases case NNS cord-350182-s10nong7 27 19 in in IN cord-350182-s10nong7 27 20 188 188 CD cord-350182-s10nong7 27 21 countries country NNS cord-350182-s10nong7 27 22 / / SYM cord-350182-s10nong7 27 23 regions region NNS cord-350182-s10nong7 27 24 causing cause VBG cord-350182-s10nong7 27 25 more more JJR cord-350182-s10nong7 27 26 than than IN cord-350182-s10nong7 27 27 500,000 500,000 CD cord-350182-s10nong7 27 28 deaths death NNS cord-350182-s10nong7 27 29 [ [ -LRB- cord-350182-s10nong7 27 30 9 9 CD cord-350182-s10nong7 27 31 ] ] -RRB- cord-350182-s10nong7 27 32 . . . cord-350182-s10nong7 28 1 Many many JJ cord-350182-s10nong7 28 2 issues issue NNS cord-350182-s10nong7 28 3 still still RB cord-350182-s10nong7 28 4 remain remain VBP cord-350182-s10nong7 28 5 to to TO cord-350182-s10nong7 28 6 be be VB cord-350182-s10nong7 28 7 determined determine VBN cord-350182-s10nong7 28 8 with with IN cord-350182-s10nong7 28 9 regard regard NN cord-350182-s10nong7 28 10 to to IN cord-350182-s10nong7 28 11 the the DT cord-350182-s10nong7 28 12 epidemiological epidemiological JJ cord-350182-s10nong7 28 13 evolution evolution NN cord-350182-s10nong7 28 14 of of IN cord-350182-s10nong7 28 15 the the DT cord-350182-s10nong7 28 16 disease disease NN cord-350182-s10nong7 28 17 , , , cord-350182-s10nong7 28 18 especially especially RB cord-350182-s10nong7 28 19 the the DT cord-350182-s10nong7 28 20 de de NN cord-350182-s10nong7 28 21 - - NN cord-350182-s10nong7 28 22 escalation escalation NN cord-350182-s10nong7 28 23 of of IN cord-350182-s10nong7 28 24 its -PRON- PRP$ cord-350182-s10nong7 28 25 prevalence prevalence NN cord-350182-s10nong7 28 26 , , , cord-350182-s10nong7 28 27 possible possible JJ cord-350182-s10nong7 28 28 seasonal seasonal JJ cord-350182-s10nong7 28 29 fluctuations fluctuation NNS cord-350182-s10nong7 28 30 of of IN cord-350182-s10nong7 28 31 its -PRON- PRP$ cord-350182-s10nong7 28 32 incidence incidence NN cord-350182-s10nong7 28 33 and and CC cord-350182-s10nong7 28 34 the the DT cord-350182-s10nong7 28 35 risk risk NN cord-350182-s10nong7 28 36 for for IN cord-350182-s10nong7 28 37 future future JJ cord-350182-s10nong7 28 38 widespread widespread JJ cord-350182-s10nong7 28 39 reoccurrences reoccurrence NNS cord-350182-s10nong7 28 40 . . . cord-350182-s10nong7 29 1 Nevertheless nevertheless RB cord-350182-s10nong7 29 2 , , , cord-350182-s10nong7 29 3 it -PRON- PRP cord-350182-s10nong7 29 4 is be VBZ cord-350182-s10nong7 29 5 already already RB cord-350182-s10nong7 29 6 known know VBN cord-350182-s10nong7 29 7 that that IN cord-350182-s10nong7 29 8 the the DT cord-350182-s10nong7 29 9 resulting result VBG cord-350182-s10nong7 29 10 outbreak outbreak NN cord-350182-s10nong7 29 11 of of IN cord-350182-s10nong7 29 12 COVID-19 COVID-19 NNP cord-350182-s10nong7 29 13 has have VBZ cord-350182-s10nong7 29 14 had have VBN cord-350182-s10nong7 29 15 a a DT cord-350182-s10nong7 29 16 detrimental detrimental JJ cord-350182-s10nong7 29 17 effect effect NN cord-350182-s10nong7 29 18 on on IN cord-350182-s10nong7 29 19 public public JJ cord-350182-s10nong7 29 20 health health NN cord-350182-s10nong7 29 21 , , , cord-350182-s10nong7 29 22 causing cause VBG cord-350182-s10nong7 29 23 numerous numerous JJ cord-350182-s10nong7 29 24 deaths death NNS cord-350182-s10nong7 29 25 and and CC cord-350182-s10nong7 29 26 burdening burden VBG cord-350182-s10nong7 29 27 tremendously tremendously RB cord-350182-s10nong7 29 28 the the DT cord-350182-s10nong7 29 29 health health NN cord-350182-s10nong7 29 30 systems system NNS cord-350182-s10nong7 29 31 worldwide worldwide RB cord-350182-s10nong7 29 32 . . . cord-350182-s10nong7 30 1 For for IN cord-350182-s10nong7 30 2 this this DT cord-350182-s10nong7 30 3 reason reason NN cord-350182-s10nong7 30 4 , , , cord-350182-s10nong7 30 5 states state NNS cord-350182-s10nong7 30 6 around around IN cord-350182-s10nong7 30 7 the the DT cord-350182-s10nong7 30 8 world world NN cord-350182-s10nong7 30 9 have have VBP cord-350182-s10nong7 30 10 been be VBN cord-350182-s10nong7 30 11 taking take VBG cord-350182-s10nong7 30 12 measures measure NNS cord-350182-s10nong7 30 13 to to TO cord-350182-s10nong7 30 14 restrict restrict VB cord-350182-s10nong7 30 15 the the DT cord-350182-s10nong7 30 16 impact impact NN cord-350182-s10nong7 30 17 of of IN cord-350182-s10nong7 30 18 the the DT cord-350182-s10nong7 30 19 spread spread NN cord-350182-s10nong7 30 20 . . . cord-350182-s10nong7 31 1 At at IN cord-350182-s10nong7 31 2 the the DT cord-350182-s10nong7 31 3 moment moment NN cord-350182-s10nong7 31 4 , , , cord-350182-s10nong7 31 5 management management NN cord-350182-s10nong7 31 6 strategies strategy NNS cord-350182-s10nong7 31 7 aim aim VBP cord-350182-s10nong7 31 8 at at IN cord-350182-s10nong7 31 9 reducing reduce VBG cord-350182-s10nong7 31 10 transmission transmission NN cord-350182-s10nong7 31 11 in in IN cord-350182-s10nong7 31 12 the the DT cord-350182-s10nong7 31 13 community community NN cord-350182-s10nong7 31 14 and and CC cord-350182-s10nong7 31 15 supporting support VBG cord-350182-s10nong7 31 16 patients patient NNS cord-350182-s10nong7 31 17 with with IN cord-350182-s10nong7 31 18 severe severe JJ cord-350182-s10nong7 31 19 clinical clinical JJ cord-350182-s10nong7 31 20 features feature NNS cord-350182-s10nong7 31 21 . . . cord-350182-s10nong7 32 1 At at IN cord-350182-s10nong7 32 2 the the DT cord-350182-s10nong7 32 3 same same JJ cord-350182-s10nong7 32 4 time time NN cord-350182-s10nong7 32 5 , , , cord-350182-s10nong7 32 6 researchers researcher NNS cord-350182-s10nong7 32 7 have have VBP cord-350182-s10nong7 32 8 been be VBN cord-350182-s10nong7 32 9 working work VBG cord-350182-s10nong7 32 10 intensively intensively RB cord-350182-s10nong7 32 11 towards towards IN cord-350182-s10nong7 32 12 the the DT cord-350182-s10nong7 32 13 establishment establishment NN cord-350182-s10nong7 32 14 of of IN cord-350182-s10nong7 32 15 novel novel JJ cord-350182-s10nong7 32 16 diagnostic diagnostic JJ cord-350182-s10nong7 32 17 procedures procedure NNS cord-350182-s10nong7 32 18 , , , cord-350182-s10nong7 32 19 effective effective JJ cord-350182-s10nong7 32 20 therapeutic therapeutic JJ cord-350182-s10nong7 32 21 regimens regimen NNS cord-350182-s10nong7 32 22 and and CC cord-350182-s10nong7 32 23 prevention prevention NN cord-350182-s10nong7 32 24 products product NNS cord-350182-s10nong7 32 25 . . . cord-350182-s10nong7 33 1 Coronaviruses coronaviruse NNS cord-350182-s10nong7 33 2 ' ' POS cord-350182-s10nong7 33 3 entry entry NN cord-350182-s10nong7 33 4 into into IN cord-350182-s10nong7 33 5 susceptible susceptible JJ cord-350182-s10nong7 33 6 cells cell NNS cord-350182-s10nong7 33 7 is be VBZ cord-350182-s10nong7 33 8 a a DT cord-350182-s10nong7 33 9 complex complex JJ cord-350182-s10nong7 33 10 process process NN cord-350182-s10nong7 33 11 that that WDT cord-350182-s10nong7 33 12 is be VBZ cord-350182-s10nong7 33 13 mediated mediate VBN cord-350182-s10nong7 33 14 through through IN cord-350182-s10nong7 33 15 binding binding NN cord-350182-s10nong7 33 16 of of IN cord-350182-s10nong7 33 17 the the DT cord-350182-s10nong7 33 18 viral viral JJ cord-350182-s10nong7 33 19 surfaceexposed surfaceexposed JJ cord-350182-s10nong7 33 20 spike spike NN cord-350182-s10nong7 33 21 ( ( -LRB- cord-350182-s10nong7 33 22 S s NN cord-350182-s10nong7 33 23 ) ) -RRB- cord-350182-s10nong7 33 24 glycoprotein glycoprotein NN cord-350182-s10nong7 33 25 to to IN cord-350182-s10nong7 33 26 the the DT cord-350182-s10nong7 33 27 host host NN cord-350182-s10nong7 33 28 cell cell NN cord-350182-s10nong7 33 29 receptor receptor NN cord-350182-s10nong7 33 30 . . . cord-350182-s10nong7 34 1 This this DT cord-350182-s10nong7 34 2 interaction interaction NN cord-350182-s10nong7 34 3 promotes promote VBZ cord-350182-s10nong7 34 4 the the DT cord-350182-s10nong7 34 5 fusion fusion NN cord-350182-s10nong7 34 6 of of IN cord-350182-s10nong7 34 7 the the DT cord-350182-s10nong7 34 8 viral viral JJ cord-350182-s10nong7 34 9 and and CC cord-350182-s10nong7 34 10 cellular cellular JJ cord-350182-s10nong7 34 11 membranes membrane NNS cord-350182-s10nong7 34 12 . . . cord-350182-s10nong7 35 1 SARS SARS NNP cord-350182-s10nong7 35 2 - - HYPH cord-350182-s10nong7 35 3 related relate VBN cord-350182-s10nong7 35 4 coronaviruses coronaviruse NNS cord-350182-s10nong7 35 5 interact interact VBP cord-350182-s10nong7 35 6 directly directly RB cord-350182-s10nong7 35 7 with with IN cord-350182-s10nong7 35 8 angiotensin angiotensin NN cord-350182-s10nong7 35 9 - - HYPH cord-350182-s10nong7 35 10 converting convert VBG cord-350182-s10nong7 35 11 enzyme enzyme NN cord-350182-s10nong7 35 12 2 2 CD cord-350182-s10nong7 35 13 ( ( -LRB- cord-350182-s10nong7 35 14 ACE2 ACE2 NNP cord-350182-s10nong7 35 15 ) ) -RRB- cord-350182-s10nong7 35 16 via via IN cord-350182-s10nong7 35 17 the the DT cord-350182-s10nong7 35 18 domain domain NN cord-350182-s10nong7 35 19 B b NN cord-350182-s10nong7 35 20 of of IN cord-350182-s10nong7 35 21 the the DT cord-350182-s10nong7 35 22 S S NNP cord-350182-s10nong7 35 23 glycoprotein glycoprotein NN cord-350182-s10nong7 35 24 to to TO cord-350182-s10nong7 35 25 enter enter VB cord-350182-s10nong7 35 26 cells cell NNS cord-350182-s10nong7 35 27 [ [ -LRB- cord-350182-s10nong7 35 28 10 10 CD cord-350182-s10nong7 35 29 ] ] -RRB- cord-350182-s10nong7 35 30 . . . cord-350182-s10nong7 36 1 ACE2 ACE2 NNP cord-350182-s10nong7 36 2 is be VBZ cord-350182-s10nong7 36 3 mainly mainly RB cord-350182-s10nong7 36 4 expressed express VBN cord-350182-s10nong7 36 5 in in IN cord-350182-s10nong7 36 6 type type NN cord-350182-s10nong7 36 7 2 2 CD cord-350182-s10nong7 36 8 alveolar alveolar NN cord-350182-s10nong7 36 9 cells cell NNS cord-350182-s10nong7 36 10 in in IN cord-350182-s10nong7 36 11 the the DT cord-350182-s10nong7 36 12 lungs lung NNS cord-350182-s10nong7 36 13 [ [ -LRB- cord-350182-s10nong7 36 14 11 11 CD cord-350182-s10nong7 36 15 ] ] -RRB- cord-350182-s10nong7 36 16 . . . cord-350182-s10nong7 37 1 The the DT cord-350182-s10nong7 37 2 first first JJ cord-350182-s10nong7 37 3 - - HYPH cord-350182-s10nong7 37 4 line line NN cord-350182-s10nong7 37 5 defence defence NN cord-350182-s10nong7 37 6 against against IN cord-350182-s10nong7 37 7 viral viral JJ cord-350182-s10nong7 37 8 infection infection NN cord-350182-s10nong7 37 9 is be VBZ cord-350182-s10nong7 37 10 the the DT cord-350182-s10nong7 37 11 production production NN cord-350182-s10nong7 37 12 of of IN cord-350182-s10nong7 37 13 type type NN cord-350182-s10nong7 37 14 I -PRON- PRP cord-350182-s10nong7 37 15 interferons interferon NNS cord-350182-s10nong7 37 16 ( ( -LRB- cord-350182-s10nong7 37 17 IFNs ifns NN cord-350182-s10nong7 37 18 - - HYPH cord-350182-s10nong7 37 19 α α NN cord-350182-s10nong7 37 20 / / SYM cord-350182-s10nong7 37 21 β β NN cord-350182-s10nong7 37 22 ) ) -RRB- cord-350182-s10nong7 37 23 which which WDT cord-350182-s10nong7 37 24 is be VBZ cord-350182-s10nong7 37 25 an an DT cord-350182-s10nong7 37 26 essential essential JJ cord-350182-s10nong7 37 27 part part NN cord-350182-s10nong7 37 28 of of IN cord-350182-s10nong7 37 29 the the DT cord-350182-s10nong7 37 30 innate innate JJ cord-350182-s10nong7 37 31 immune immune JJ cord-350182-s10nong7 37 32 system system NN cord-350182-s10nong7 37 33 . . . cord-350182-s10nong7 38 1 In in IN cord-350182-s10nong7 38 2 RNA RNA NNP cord-350182-s10nong7 38 3 viruses virus NNS cord-350182-s10nong7 38 4 , , , cord-350182-s10nong7 38 5 such such JJ cord-350182-s10nong7 38 6 as as IN cord-350182-s10nong7 38 7 the the DT cord-350182-s10nong7 38 8 coronaviruses coronaviruse NNS cord-350182-s10nong7 38 9 , , , cord-350182-s10nong7 38 10 the the DT cord-350182-s10nong7 38 11 viral viral JJ cord-350182-s10nong7 38 12 genome genome NN cord-350182-s10nong7 38 13 or or CC cord-350182-s10nong7 38 14 the the DT cord-350182-s10nong7 38 15 intermediates intermediate NNS cord-350182-s10nong7 38 16 during during IN cord-350182-s10nong7 38 17 viral viral JJ cord-350182-s10nong7 38 18 replication replication NN cord-350182-s10nong7 38 19 are be VBP cord-350182-s10nong7 38 20 recognised recognise VBN cord-350182-s10nong7 38 21 by by IN cord-350182-s10nong7 38 22 either either CC cord-350182-s10nong7 38 23 endosomal endosomal NNP cord-350182-s10nong7 38 24 RNA RNA NNP cord-350182-s10nong7 38 25 receptors receptor NNS cord-350182-s10nong7 38 26 or or CC cord-350182-s10nong7 38 27 cytosolic cytosolic JJ cord-350182-s10nong7 38 28 RNA RNA NNP cord-350182-s10nong7 38 29 sensors sensor NNS cord-350182-s10nong7 38 30 in in IN cord-350182-s10nong7 38 31 all all DT cord-350182-s10nong7 38 32 nucleated nucleated JJ cord-350182-s10nong7 38 33 cells cell NNS cord-350182-s10nong7 38 34 of of IN cord-350182-s10nong7 38 35 mammalians mammalian NNS cord-350182-s10nong7 38 36 . . . cord-350182-s10nong7 39 1 This this DT cord-350182-s10nong7 39 2 interaction interaction NN cord-350182-s10nong7 39 3 leads lead VBZ cord-350182-s10nong7 39 4 to to IN cord-350182-s10nong7 39 5 a a DT cord-350182-s10nong7 39 6 downstream downstream JJ cord-350182-s10nong7 39 7 signalling signal VBG cord-350182-s10nong7 39 8 cascade cascade NN cord-350182-s10nong7 39 9 and and CC cord-350182-s10nong7 39 10 an an DT cord-350182-s10nong7 39 11 accompanying accompany VBG cord-350182-s10nong7 39 12 translocation translocation NN cord-350182-s10nong7 39 13 of of IN cord-350182-s10nong7 39 14 nuclear nuclear JJ cord-350182-s10nong7 39 15 factors factor NNS cord-350182-s10nong7 39 16 . . . cord-350182-s10nong7 40 1 This this DT cord-350182-s10nong7 40 2 process process NN cord-350182-s10nong7 40 3 results result VBZ cord-350182-s10nong7 40 4 in in IN cord-350182-s10nong7 40 5 expression expression NN cord-350182-s10nong7 40 6 of of IN cord-350182-s10nong7 40 7 IFNs ifn NNS cord-350182-s10nong7 40 8 - - HYPH cord-350182-s10nong7 40 9 α α NNP cord-350182-s10nong7 40 10 / / SYM cord-350182-s10nong7 40 11 β β NN cord-350182-s10nong7 40 12 and and CC cord-350182-s10nong7 40 13 other other JJ cord-350182-s10nong7 40 14 pro pro JJ cord-350182-s10nong7 40 15 - - JJ cord-350182-s10nong7 40 16 inflammatory inflammatory JJ cord-350182-s10nong7 40 17 cytokines cytokine NNS cord-350182-s10nong7 40 18 . . . cord-350182-s10nong7 41 1 These these DT cord-350182-s10nong7 41 2 interferons interferon NNS cord-350182-s10nong7 41 3 act act VBP cord-350182-s10nong7 41 4 to to IN cord-350182-s10nong7 41 5 neighbouring neighbouring NN cord-350182-s10nong7 41 6 cells cell NNS cord-350182-s10nong7 41 7 and and CC cord-350182-s10nong7 41 8 via via IN cord-350182-s10nong7 41 9 the the DT cord-350182-s10nong7 41 10 JAK JAK NNP cord-350182-s10nong7 41 11 - - HYPH cord-350182-s10nong7 41 12 STAT STAT NNP cord-350182-s10nong7 41 13 pathway pathway NN cord-350182-s10nong7 41 14 stimulate stimulate VBP cord-350182-s10nong7 41 15 the the DT cord-350182-s10nong7 41 16 expression expression NN cord-350182-s10nong7 41 17 of of IN cord-350182-s10nong7 41 18 antiviral antiviral JJ cord-350182-s10nong7 41 19 proteins protein NNS cord-350182-s10nong7 41 20 and and CC cord-350182-s10nong7 41 21 induce induce VB cord-350182-s10nong7 41 22 other other JJ cord-350182-s10nong7 41 23 biological biological JJ cord-350182-s10nong7 41 24 activities activity NNS cord-350182-s10nong7 41 25 such such JJ cord-350182-s10nong7 41 26 as as IN cord-350182-s10nong7 41 27 inhibition inhibition NN cord-350182-s10nong7 41 28 of of IN cord-350182-s10nong7 41 29 cell cell NN cord-350182-s10nong7 41 30 proliferation proliferation NN cord-350182-s10nong7 41 31 , , , cord-350182-s10nong7 41 32 regulation regulation NN cord-350182-s10nong7 41 33 of of IN cord-350182-s10nong7 41 34 apoptosis apoptosis NN cord-350182-s10nong7 41 35 and and CC cord-350182-s10nong7 41 36 immunomodulation immunomodulation NN cord-350182-s10nong7 41 37 [ [ -LRB- cord-350182-s10nong7 41 38 12 12 CD cord-350182-s10nong7 41 39 ] ] -RRB- cord-350182-s10nong7 41 40 . . . cord-350182-s10nong7 42 1 A a DT cord-350182-s10nong7 42 2 successful successful JJ cord-350182-s10nong7 42 3 response response NN cord-350182-s10nong7 42 4 of of IN cord-350182-s10nong7 42 5 the the DT cord-350182-s10nong7 42 6 IFNs ifns NN cord-350182-s10nong7 42 7 - - HYPH cord-350182-s10nong7 42 8 α α NN cord-350182-s10nong7 42 9 / / SYM cord-350182-s10nong7 42 10 β β NN cord-350182-s10nong7 42 11 - - HYPH cord-350182-s10nong7 42 12 related relate VBN cord-350182-s10nong7 42 13 innate innate JJ cord-350182-s10nong7 42 14 immune immune JJ cord-350182-s10nong7 42 15 system system NN cord-350182-s10nong7 42 16 should should MD cord-350182-s10nong7 42 17 be be VB cord-350182-s10nong7 42 18 able able JJ cord-350182-s10nong7 42 19 to to TO cord-350182-s10nong7 42 20 control control VB cord-350182-s10nong7 42 21 viral viral JJ cord-350182-s10nong7 42 22 replication replication NN cord-350182-s10nong7 42 23 and and CC cord-350182-s10nong7 42 24 dispersion dispersion NN cord-350182-s10nong7 42 25 in in IN cord-350182-s10nong7 42 26 the the DT cord-350182-s10nong7 42 27 body body NN cord-350182-s10nong7 42 28 at at IN cord-350182-s10nong7 42 29 an an DT cord-350182-s10nong7 42 30 early early JJ cord-350182-s10nong7 42 31 stage stage NN cord-350182-s10nong7 42 32 , , , cord-350182-s10nong7 42 33 at at IN cord-350182-s10nong7 42 34 least least JJS cord-350182-s10nong7 42 35 to to IN cord-350182-s10nong7 42 36 an an DT cord-350182-s10nong7 42 37 extent extent NN cord-350182-s10nong7 42 38 . . . cord-350182-s10nong7 43 1 However however RB cord-350182-s10nong7 43 2 , , , cord-350182-s10nong7 43 3 it -PRON- PRP cord-350182-s10nong7 43 4 is be VBZ cord-350182-s10nong7 43 5 believed believe VBN cord-350182-s10nong7 43 6 that that IN cord-350182-s10nong7 43 7 SARS SARS NNP cord-350182-s10nong7 43 8 CoV-2 CoV-2 NNP cord-350182-s10nong7 43 9 is be VBZ cord-350182-s10nong7 43 10 able able JJ cord-350182-s10nong7 43 11 to to TO cord-350182-s10nong7 43 12 subvert subvert VB cord-350182-s10nong7 43 13 the the DT cord-350182-s10nong7 43 14 host host NN cord-350182-s10nong7 43 15 response response NN cord-350182-s10nong7 43 16 through through IN cord-350182-s10nong7 43 17 the the DT cord-350182-s10nong7 43 18 action action NN cord-350182-s10nong7 43 19 of of IN cord-350182-s10nong7 43 20 structural structural JJ cord-350182-s10nong7 43 21 and and CC cord-350182-s10nong7 43 22 nonstructural nonstructural JJ cord-350182-s10nong7 43 23 proteins protein NNS cord-350182-s10nong7 43 24 . . . cord-350182-s10nong7 44 1 Due due IN cord-350182-s10nong7 44 2 to to IN cord-350182-s10nong7 44 3 the the DT cord-350182-s10nong7 44 4 genomic genomic JJ cord-350182-s10nong7 44 5 sequence sequence NN cord-350182-s10nong7 44 6 similarities similarity NNS cord-350182-s10nong7 44 7 with with IN cord-350182-s10nong7 44 8 SARS SARS NNP cord-350182-s10nong7 44 9 - - HYPH cord-350182-s10nong7 44 10 CoV CoV NNP cord-350182-s10nong7 44 11 ( ( -LRB- cord-350182-s10nong7 44 12 and and CC cord-350182-s10nong7 44 13 secondarily secondarily RB cord-350182-s10nong7 44 14 with with IN cord-350182-s10nong7 44 15 MERS MERS NNP cord-350182-s10nong7 44 16 - - HYPH cord-350182-s10nong7 44 17 CoV CoV NNP cord-350182-s10nong7 44 18 ) ) -RRB- cord-350182-s10nong7 44 19 , , , cord-350182-s10nong7 44 20 it -PRON- PRP cord-350182-s10nong7 44 21 is be VBZ cord-350182-s10nong7 44 22 assumed assume VBN cord-350182-s10nong7 44 23 that that IN cord-350182-s10nong7 44 24 SARS SARS NNP cord-350182-s10nong7 44 25 - - HYPH cord-350182-s10nong7 44 26 CoV-2 CoV-2 NNP cord-350182-s10nong7 44 27 interferes interfere VBZ cord-350182-s10nong7 44 28 with with IN cord-350182-s10nong7 44 29 the the DT cord-350182-s10nong7 44 30 relevant relevant JJ cord-350182-s10nong7 44 31 signalling signalling NN cord-350182-s10nong7 44 32 processes process NNS cord-350182-s10nong7 44 33 of of IN cord-350182-s10nong7 44 34 the the DT cord-350182-s10nong7 44 35 host host NN cord-350182-s10nong7 44 36 cells cell NNS cord-350182-s10nong7 44 37 through through IN cord-350182-s10nong7 44 38 degradation degradation NN cord-350182-s10nong7 44 39 or or CC cord-350182-s10nong7 44 40 inhibition inhibition NN cord-350182-s10nong7 44 41 of of IN cord-350182-s10nong7 44 42 involved involve VBN cord-350182-s10nong7 44 43 cellular cellular JJ cord-350182-s10nong7 44 44 molecules molecule NNS cord-350182-s10nong7 44 45 . . . cord-350182-s10nong7 45 1 Consequently consequently RB cord-350182-s10nong7 45 2 , , , cord-350182-s10nong7 45 3 the the DT cord-350182-s10nong7 45 4 delayed delayed JJ cord-350182-s10nong7 45 5 or or CC cord-350182-s10nong7 45 6 vitiated vitiate VBN cord-350182-s10nong7 45 7 INFs inf NNS cord-350182-s10nong7 45 8 - - HYPH cord-350182-s10nong7 45 9 α α NNP cord-350182-s10nong7 45 10 / / SYM cord-350182-s10nong7 45 11 β β NN cord-350182-s10nong7 45 12 response response NN cord-350182-s10nong7 45 13 compromises compromise VBZ cord-350182-s10nong7 45 14 the the DT cord-350182-s10nong7 45 15 early early JJ cord-350182-s10nong7 45 16 viral viral JJ cord-350182-s10nong7 45 17 control control NN cord-350182-s10nong7 45 18 , , , cord-350182-s10nong7 45 19 leading lead VBG cord-350182-s10nong7 45 20 to to IN cord-350182-s10nong7 45 21 escalation escalation NN cord-350182-s10nong7 45 22 of of IN cord-350182-s10nong7 45 23 the the DT cord-350182-s10nong7 45 24 concentration concentration NN cord-350182-s10nong7 45 25 of of IN cord-350182-s10nong7 45 26 inflammatory inflammatory JJ cord-350182-s10nong7 45 27 neutrophils neutrophil NNS cord-350182-s10nong7 45 28 and and CC cord-350182-s10nong7 45 29 monocytes monocyte NNS cord-350182-s10nong7 45 30 and and CC cord-350182-s10nong7 45 31 in in IN cord-350182-s10nong7 45 32 turn turn NN cord-350182-s10nong7 45 33 to to IN cord-350182-s10nong7 45 34 overproduction overproduction NN cord-350182-s10nong7 45 35 of of IN cord-350182-s10nong7 45 36 pro pro JJ cord-350182-s10nong7 45 37 - - JJ cord-350182-s10nong7 45 38 inflammatory inflammatory JJ cord-350182-s10nong7 45 39 cytokines cytokine NNS cord-350182-s10nong7 45 40 ( ( -LRB- cord-350182-s10nong7 45 41 ' ' `` cord-350182-s10nong7 45 42 cytokine cytokine NN cord-350182-s10nong7 45 43 storm storm NN cord-350182-s10nong7 45 44 ' ' '' cord-350182-s10nong7 45 45 ) ) -RRB- cord-350182-s10nong7 45 46 that that WDT cord-350182-s10nong7 45 47 manifest manifest VBP cord-350182-s10nong7 45 48 the the DT cord-350182-s10nong7 45 49 lung lung NN cord-350182-s10nong7 45 50 immunopathology immunopathology NN cord-350182-s10nong7 45 51 of of IN cord-350182-s10nong7 45 52 COVID-19 COVID-19 NNP cord-350182-s10nong7 45 53 [ [ -LRB- cord-350182-s10nong7 45 54 13 13 CD cord-350182-s10nong7 45 55 ] ] -RRB- cord-350182-s10nong7 45 56 . . . cord-350182-s10nong7 46 1 The the DT cord-350182-s10nong7 46 2 adaptive adaptive JJ cord-350182-s10nong7 46 3 immunity immunity NN cord-350182-s10nong7 46 4 response response NN cord-350182-s10nong7 46 5 to to IN cord-350182-s10nong7 46 6 SARS SARS NNP cord-350182-s10nong7 46 7 - - HYPH cord-350182-s10nong7 46 8 CoV-2 CoV-2 NNP cord-350182-s10nong7 46 9 has have VBZ cord-350182-s10nong7 46 10 not not RB cord-350182-s10nong7 46 11 yet yet RB cord-350182-s10nong7 46 12 been be VBN cord-350182-s10nong7 46 13 clarified clarify VBN cord-350182-s10nong7 46 14 . . . cord-350182-s10nong7 47 1 Presumably presumably RB cord-350182-s10nong7 47 2 , , , cord-350182-s10nong7 47 3 antigens antigen NNS cord-350182-s10nong7 47 4 from from IN cord-350182-s10nong7 47 5 invading invade VBG cord-350182-s10nong7 47 6 pathogens pathogen NNS cord-350182-s10nong7 47 7 ( ( -LRB- cord-350182-s10nong7 47 8 most most RBS cord-350182-s10nong7 47 9 probably probably RB cord-350182-s10nong7 47 10 the the DT cord-350182-s10nong7 47 11 surface surface NN cord-350182-s10nong7 47 12 - - HYPH cord-350182-s10nong7 47 13 exposed expose VBN cord-350182-s10nong7 47 14 spike spike NN cord-350182-s10nong7 47 15 glycoprotein glycoprotein NN cord-350182-s10nong7 47 16 but but CC cord-350182-s10nong7 47 17 perhaps perhaps RB cord-350182-s10nong7 47 18 also also RB cord-350182-s10nong7 47 19 the the DT cord-350182-s10nong7 47 20 membrane membrane NN cord-350182-s10nong7 47 21 protein protein NN cord-350182-s10nong7 47 22 ) ) -RRB- cord-350182-s10nong7 47 23 are be VBP cord-350182-s10nong7 47 24 acquired acquire VBN cord-350182-s10nong7 47 25 by by IN cord-350182-s10nong7 47 26 respiratory respiratory JJ cord-350182-s10nong7 47 27 dendritic dendritic JJ cord-350182-s10nong7 47 28 cells cell NNS cord-350182-s10nong7 47 29 which which WDT cord-350182-s10nong7 47 30 become become VBP cord-350182-s10nong7 47 31 activated activate VBN cord-350182-s10nong7 47 32 and and CC cord-350182-s10nong7 47 33 present present VB cord-350182-s10nong7 47 34 the the DT cord-350182-s10nong7 47 35 processed process VBN cord-350182-s10nong7 47 36 antigen antigen NN cord-350182-s10nong7 47 37 to to IN cord-350182-s10nong7 47 38 circulating circulate VBG cord-350182-s10nong7 47 39 T t NN cord-350182-s10nong7 47 40 cells cell NNS cord-350182-s10nong7 47 41 . . . cord-350182-s10nong7 48 1 Activated Activated NNP cord-350182-s10nong7 48 2 CD4 CD4 NNP cord-350182-s10nong7 48 3 + + CC cord-350182-s10nong7 48 4 T t NN cord-350182-s10nong7 48 5 cells cell NNS cord-350182-s10nong7 48 6 promote promote VBP cord-350182-s10nong7 48 7 the the DT cord-350182-s10nong7 48 8 production production NN cord-350182-s10nong7 48 9 of of IN cord-350182-s10nong7 48 10 virus virus NN cord-350182-s10nong7 48 11 - - HYPH cord-350182-s10nong7 48 12 specific specific JJ cord-350182-s10nong7 48 13 antibodies antibody NNS cord-350182-s10nong7 48 14 by by IN cord-350182-s10nong7 48 15 activating activate VBG cord-350182-s10nong7 48 16 T T NNP cord-350182-s10nong7 48 17 - - HYPH cord-350182-s10nong7 48 18 dependent dependent JJ cord-350182-s10nong7 48 19 B b NN cord-350182-s10nong7 48 20 cells cell NNS cord-350182-s10nong7 48 21 , , , cord-350182-s10nong7 48 22 whilst whilst IN cord-350182-s10nong7 48 23 CD8 CD8 NNP cord-350182-s10nong7 48 24 + + CC cord-350182-s10nong7 48 25 T T NNP cord-350182-s10nong7 48 26 cells cell NNS cord-350182-s10nong7 48 27 are be VBP cord-350182-s10nong7 48 28 cytotoxic cytotoxic JJ cord-350182-s10nong7 48 29 and and CC cord-350182-s10nong7 48 30 can can MD cord-350182-s10nong7 48 31 kill kill VB cord-350182-s10nong7 48 32 infected infected JJ cord-350182-s10nong7 48 33 cells cell NNS cord-350182-s10nong7 48 34 . . . cord-350182-s10nong7 49 1 In in IN cord-350182-s10nong7 49 2 addition addition NN cord-350182-s10nong7 49 3 , , , cord-350182-s10nong7 49 4 B b NN cord-350182-s10nong7 49 5 cells cell NNS cord-350182-s10nong7 49 6 produce produce VBP cord-350182-s10nong7 49 7 specific specific JJ cord-350182-s10nong7 49 8 antibodies antibody NNS cord-350182-s10nong7 49 9 which which WDT cord-350182-s10nong7 49 10 may may MD cord-350182-s10nong7 49 11 neutralise neutralise VB cord-350182-s10nong7 49 12 the the DT cord-350182-s10nong7 49 13 invading invade VBG cord-350182-s10nong7 49 14 viruses virus NNS cord-350182-s10nong7 49 15 [ [ -LRB- cord-350182-s10nong7 49 16 14 14 CD cord-350182-s10nong7 49 17 ] ] -RRB- cord-350182-s10nong7 49 18 . . . cord-350182-s10nong7 50 1 If if IN cord-350182-s10nong7 50 2 the the DT cord-350182-s10nong7 50 3 pathogenesis pathogenesis NN cord-350182-s10nong7 50 4 in in IN cord-350182-s10nong7 50 5 SARS SARS NNP cord-350182-s10nong7 50 6 applies apply VBZ cord-350182-s10nong7 50 7 to to IN cord-350182-s10nong7 50 8 COVID-19 covid-19 VB cord-350182-s10nong7 50 9 , , , cord-350182-s10nong7 50 10 the the DT cord-350182-s10nong7 50 11 upregulation upregulation NN cord-350182-s10nong7 50 12 of of IN cord-350182-s10nong7 50 13 pro pro JJ cord-350182-s10nong7 50 14 - - JJ cord-350182-s10nong7 50 15 inflammatory inflammatory JJ cord-350182-s10nong7 50 16 cytokines cytokine NNS cord-350182-s10nong7 50 17 during during IN cord-350182-s10nong7 50 18 the the DT cord-350182-s10nong7 50 19 delayed delay VBN cord-350182-s10nong7 50 20 innate innate JJ cord-350182-s10nong7 50 21 immunity immunity NN cord-350182-s10nong7 50 22 potentiates potentiate VBZ cord-350182-s10nong7 50 23 the the DT cord-350182-s10nong7 50 24 occurrence occurrence NN cord-350182-s10nong7 50 25 of of IN cord-350182-s10nong7 50 26 severe severe JJ cord-350182-s10nong7 50 27 respiratory respiratory JJ cord-350182-s10nong7 50 28 manifestations manifestation NNS cord-350182-s10nong7 50 29 , , , cord-350182-s10nong7 50 30 whilst whilst IN cord-350182-s10nong7 50 31 the the DT cord-350182-s10nong7 50 32 progression progression NN cord-350182-s10nong7 50 33 to to IN cord-350182-s10nong7 50 34 adaptive adaptive JJ cord-350182-s10nong7 50 35 immunity immunity NN cord-350182-s10nong7 50 36 is be VBZ cord-350182-s10nong7 50 37 correlated correlate VBN cord-350182-s10nong7 50 38 with with IN cord-350182-s10nong7 50 39 recovery recovery NN cord-350182-s10nong7 50 40 [ [ -LRB- cord-350182-s10nong7 50 41 15 15 CD cord-350182-s10nong7 50 42 ] ] -RRB- cord-350182-s10nong7 50 43 . . . cord-350182-s10nong7 51 1 Diabetes diabetes NN cord-350182-s10nong7 51 2 mellitus mellitus NN cord-350182-s10nong7 51 3 is be VBZ cord-350182-s10nong7 51 4 a a DT cord-350182-s10nong7 51 5 clinical clinical JJ cord-350182-s10nong7 51 6 syndrome syndrome NN cord-350182-s10nong7 51 7 of of IN cord-350182-s10nong7 51 8 impaired impaired JJ cord-350182-s10nong7 51 9 glucose glucose NN cord-350182-s10nong7 51 10 metabolism metabolism NN cord-350182-s10nong7 51 11 with with IN cord-350182-s10nong7 51 12 inappropriate inappropriate JJ cord-350182-s10nong7 51 13 hyperglycaemia hyperglycaemia NN cord-350182-s10nong7 51 14 due due JJ cord-350182-s10nong7 51 15 to to IN cord-350182-s10nong7 51 16 absolute absolute JJ cord-350182-s10nong7 51 17 or or CC cord-350182-s10nong7 51 18 relative relative JJ cord-350182-s10nong7 51 19 deficiency deficiency NN cord-350182-s10nong7 51 20 in in IN cord-350182-s10nong7 51 21 insulin insulin NN cord-350182-s10nong7 51 22 secretion secretion NN cord-350182-s10nong7 51 23 , , , cord-350182-s10nong7 51 24 resistance resistance NN cord-350182-s10nong7 51 25 to to IN cord-350182-s10nong7 51 26 insulin insulin NN cord-350182-s10nong7 51 27 action action NN cord-350182-s10nong7 51 28 , , , cord-350182-s10nong7 51 29 or or CC cord-350182-s10nong7 51 30 both both DT cord-350182-s10nong7 51 31 [ [ -LRB- cord-350182-s10nong7 51 32 16 16 CD cord-350182-s10nong7 51 33 ] ] -RRB- cord-350182-s10nong7 51 34 . . . cord-350182-s10nong7 52 1 The the DT cord-350182-s10nong7 52 2 most most RBS cord-350182-s10nong7 52 3 common common JJ cord-350182-s10nong7 52 4 types type NNS cord-350182-s10nong7 52 5 of of IN cord-350182-s10nong7 52 6 diabetes diabetes NN cord-350182-s10nong7 52 7 mellitus mellitus NN cord-350182-s10nong7 52 8 include include VBP cord-350182-s10nong7 52 9 type type NN cord-350182-s10nong7 52 10 1 1 CD cord-350182-s10nong7 52 11 and and CC cord-350182-s10nong7 52 12 type type NN cord-350182-s10nong7 52 13 2 2 CD cord-350182-s10nong7 52 14 diabetes diabetes NN cord-350182-s10nong7 52 15 [ [ -LRB- cord-350182-s10nong7 52 16 17 17 CD cord-350182-s10nong7 52 17 ] ] -RRB- cord-350182-s10nong7 52 18 . . . cord-350182-s10nong7 53 1 Although although IN cord-350182-s10nong7 53 2 the the DT cord-350182-s10nong7 53 3 clinical clinical JJ cord-350182-s10nong7 53 4 diagnosis diagnosis NN cord-350182-s10nong7 53 5 of of IN cord-350182-s10nong7 53 6 the the DT cord-350182-s10nong7 53 7 type type NN cord-350182-s10nong7 53 8 of of IN cord-350182-s10nong7 53 9 diabetes diabetes NN cord-350182-s10nong7 53 10 is be VBZ cord-350182-s10nong7 53 11 not not RB cord-350182-s10nong7 53 12 always always RB cord-350182-s10nong7 53 13 straightforward straightforward JJ cord-350182-s10nong7 53 14 , , , cord-350182-s10nong7 53 15 type type NN cord-350182-s10nong7 53 16 1 1 CD cord-350182-s10nong7 53 17 and and CC cord-350182-s10nong7 53 18 type type NN cord-350182-s10nong7 53 19 2 2 CD cord-350182-s10nong7 53 20 diabetes diabete NNS cord-350182-s10nong7 53 21 are be VBP cord-350182-s10nong7 53 22 heterogeneous heterogeneous JJ cord-350182-s10nong7 53 23 diseases disease NNS cord-350182-s10nong7 53 24 with with IN cord-350182-s10nong7 53 25 considerably considerably RB cord-350182-s10nong7 53 26 different different JJ cord-350182-s10nong7 53 27 pathophysiology pathophysiology NN cord-350182-s10nong7 53 28 . . . cord-350182-s10nong7 54 1 Type type NN cord-350182-s10nong7 54 2 1 1 CD cord-350182-s10nong7 54 3 diabetes diabetes NN cord-350182-s10nong7 54 4 is be VBZ cord-350182-s10nong7 54 5 a a DT cord-350182-s10nong7 54 6 catabolic catabolic JJ cord-350182-s10nong7 54 7 disorder disorder NN cord-350182-s10nong7 54 8 in in IN cord-350182-s10nong7 54 9 which which WDT cord-350182-s10nong7 54 10 pancreatic pancreatic NN cord-350182-s10nong7 54 11 β β NN cord-350182-s10nong7 54 12 - - HYPH cord-350182-s10nong7 54 13 cells cell NNS cord-350182-s10nong7 54 14 fail fail VBP cord-350182-s10nong7 54 15 to to TO cord-350182-s10nong7 54 16 respond respond VB cord-350182-s10nong7 54 17 to to IN cord-350182-s10nong7 54 18 all all DT cord-350182-s10nong7 54 19 insulinogenic insulinogenic JJ cord-350182-s10nong7 54 20 stimuli stimulus NNS cord-350182-s10nong7 54 21 mainly mainly RB cord-350182-s10nong7 54 22 due due JJ cord-350182-s10nong7 54 23 to to IN cord-350182-s10nong7 54 24 immune immune NN cord-350182-s10nong7 54 25 - - HYPH cord-350182-s10nong7 54 26 mediated mediate VBN cord-350182-s10nong7 54 27 and and CC cord-350182-s10nong7 54 28 less less RBR cord-350182-s10nong7 54 29 frequently frequently RB cord-350182-s10nong7 54 30 due due JJ cord-350182-s10nong7 54 31 to to IN cord-350182-s10nong7 54 32 idiopathic idiopathic JJ cord-350182-s10nong7 54 33 destruction destruction NN cord-350182-s10nong7 54 34 . . . cord-350182-s10nong7 55 1 [ [ -LRB- cord-350182-s10nong7 55 2 18 18 CD cord-350182-s10nong7 55 3 , , , cord-350182-s10nong7 55 4 19 19 CD cord-350182-s10nong7 55 5 ] ] -RRB- cord-350182-s10nong7 55 6 . . . cord-350182-s10nong7 56 1 Type type NN cord-350182-s10nong7 56 2 2diabetes 2diabetes CD cord-350182-s10nong7 56 3 is be VBZ cord-350182-s10nong7 56 4 characterised characterise VBN cord-350182-s10nong7 56 5 by by IN cord-350182-s10nong7 56 6 various various JJ cord-350182-s10nong7 56 7 degrees degree NNS cord-350182-s10nong7 56 8 of of IN cord-350182-s10nong7 56 9 resistance resistance NN cord-350182-s10nong7 56 10 to to IN cord-350182-s10nong7 56 11 insulin insulin NN cord-350182-s10nong7 56 12 action action NN cord-350182-s10nong7 56 13 and and CC cord-350182-s10nong7 56 14 insulin insulin NN cord-350182-s10nong7 56 15 secretory secretory JJ cord-350182-s10nong7 56 16 defect defect NN cord-350182-s10nong7 56 17 and and CC cord-350182-s10nong7 56 18 is be VBZ cord-350182-s10nong7 56 19 associated associate VBN cord-350182-s10nong7 56 20 with with IN cord-350182-s10nong7 56 21 other other JJ cord-350182-s10nong7 56 22 metabolic metabolic JJ cord-350182-s10nong7 56 23 disorders disorder NNS cord-350182-s10nong7 56 24 of of IN cord-350182-s10nong7 56 25 the the DT cord-350182-s10nong7 56 26 muscle muscle NN cord-350182-s10nong7 56 27 tissue tissue NN cord-350182-s10nong7 56 28 , , , cord-350182-s10nong7 56 29 liver liver NN cord-350182-s10nong7 56 30 , , , cord-350182-s10nong7 56 31 fat fat JJ cord-350182-s10nong7 56 32 cells cell NNS cord-350182-s10nong7 56 33 , , , cord-350182-s10nong7 56 34 gastrointestinal gastrointestinal JJ cord-350182-s10nong7 56 35 tract tract NN cord-350182-s10nong7 56 36 , , , cord-350182-s10nong7 56 37 pancreatic pancreatic NN cord-350182-s10nong7 56 38 α α NN cord-350182-s10nong7 56 39 - - HYPH cord-350182-s10nong7 56 40 cells cell NNS cord-350182-s10nong7 56 41 , , , cord-350182-s10nong7 56 42 kidneys kidney NNS cord-350182-s10nong7 56 43 , , , cord-350182-s10nong7 56 44 and and CC cord-350182-s10nong7 56 45 brain brain NN cord-350182-s10nong7 56 46 [ [ -LRB- cord-350182-s10nong7 56 47 20 20 CD cord-350182-s10nong7 56 48 ] ] -RRB- cord-350182-s10nong7 56 49 . . . cord-350182-s10nong7 57 1 The the DT cord-350182-s10nong7 57 2 global global JJ cord-350182-s10nong7 57 3 prevalence prevalence NN cord-350182-s10nong7 57 4 of of IN cord-350182-s10nong7 57 5 diabetes diabetes NN cord-350182-s10nong7 57 6 mellitus mellitus NN cord-350182-s10nong7 57 7 has have VBZ cord-350182-s10nong7 57 8 risen rise VBN cord-350182-s10nong7 57 9 dramatically dramatically RB cord-350182-s10nong7 57 10 over over IN cord-350182-s10nong7 57 11 the the DT cord-350182-s10nong7 57 12 past past JJ cord-350182-s10nong7 57 13 forty forty CD cord-350182-s10nong7 57 14 years year NNS cord-350182-s10nong7 57 15 and and CC cord-350182-s10nong7 57 16 it -PRON- PRP cord-350182-s10nong7 57 17 is be VBZ cord-350182-s10nong7 57 18 expected expect VBN cord-350182-s10nong7 57 19 to to TO cord-350182-s10nong7 57 20 grow grow VB cord-350182-s10nong7 57 21 further further RB cord-350182-s10nong7 57 22 over over IN cord-350182-s10nong7 57 23 the the DT cord-350182-s10nong7 57 24 next next JJ cord-350182-s10nong7 57 25 decades decade NNS cord-350182-s10nong7 57 26 . . . cord-350182-s10nong7 58 1 In in IN cord-350182-s10nong7 58 2 2019 2019 CD cord-350182-s10nong7 58 3 , , , cord-350182-s10nong7 58 4 it -PRON- PRP cord-350182-s10nong7 58 5 was be VBD cord-350182-s10nong7 58 6 approximately approximately RB cord-350182-s10nong7 58 7 9.3 9.3 CD cord-350182-s10nong7 58 8 % % NN cord-350182-s10nong7 58 9 ( ( -LRB- cord-350182-s10nong7 58 10 463 463 CD cord-350182-s10nong7 58 11 million million CD cord-350182-s10nong7 58 12 people people NNS cord-350182-s10nong7 58 13 ) ) -RRB- cord-350182-s10nong7 58 14 and and CC cord-350182-s10nong7 58 15 it -PRON- PRP cord-350182-s10nong7 58 16 is be VBZ cord-350182-s10nong7 58 17 estimated estimate VBN cord-350182-s10nong7 58 18 to to TO cord-350182-s10nong7 58 19 rise rise VB cord-350182-s10nong7 58 20 around around RB cord-350182-s10nong7 58 21 to to IN cord-350182-s10nong7 58 22 10.2 10.2 CD cord-350182-s10nong7 58 23 % % NN cord-350182-s10nong7 58 24 ( ( -LRB- cord-350182-s10nong7 58 25 578 578 CD cord-350182-s10nong7 58 26 million million CD cord-350182-s10nong7 58 27 ) ) -RRB- cord-350182-s10nong7 58 28 by by IN cord-350182-s10nong7 58 29 2030 2030 CD cord-350182-s10nong7 58 30 and and CC cord-350182-s10nong7 58 31 10.9 10.9 CD cord-350182-s10nong7 58 32 % % NN cord-350182-s10nong7 58 33 ( ( -LRB- cord-350182-s10nong7 58 34 700 700 CD cord-350182-s10nong7 58 35 million million CD cord-350182-s10nong7 58 36 ) ) -RRB- cord-350182-s10nong7 58 37 by by IN cord-350182-s10nong7 58 38 2045 2045 CD cord-350182-s10nong7 58 39 [ [ -LRB- cord-350182-s10nong7 58 40 21 21 CD cord-350182-s10nong7 58 41 ] ] -RRB- cord-350182-s10nong7 58 42 . . . cord-350182-s10nong7 59 1 Chronic Chronic NNP cord-350182-s10nong7 59 2 hyperglycaemia hyperglycaemia NN cord-350182-s10nong7 59 3 is be VBZ cord-350182-s10nong7 59 4 associated associate VBN cord-350182-s10nong7 59 5 with with IN cord-350182-s10nong7 59 6 increased increase VBN cord-350182-s10nong7 59 7 susceptibility susceptibility NN cord-350182-s10nong7 59 8 to to IN cord-350182-s10nong7 59 9 pathogens pathogen NNS cord-350182-s10nong7 59 10 . . . cord-350182-s10nong7 60 1 Many many JJ cord-350182-s10nong7 60 2 common common JJ cord-350182-s10nong7 60 3 infections infection NNS cord-350182-s10nong7 60 4 are be VBP cord-350182-s10nong7 60 5 more more RBR cord-350182-s10nong7 60 6 frequent frequent JJ cord-350182-s10nong7 60 7 and and CC cord-350182-s10nong7 60 8 severe severe JJ cord-350182-s10nong7 60 9 in in IN cord-350182-s10nong7 60 10 individuals individual NNS cord-350182-s10nong7 60 11 with with IN cord-350182-s10nong7 60 12 diabetes diabetes NN cord-350182-s10nong7 60 13 mellitus mellitus NN cord-350182-s10nong7 60 14 , , , cord-350182-s10nong7 60 15 whilst whilst IN cord-350182-s10nong7 60 16 some some DT cord-350182-s10nong7 60 17 rare rare JJ cord-350182-s10nong7 60 18 infections infection NNS cord-350182-s10nong7 60 19 ( ( -LRB- cord-350182-s10nong7 60 20 e.g. e.g. RB cord-350182-s10nong7 60 21 rhinocerebral rhinocerebral NNP cord-350182-s10nong7 60 22 mucormycosis mucormycosis NNP cord-350182-s10nong7 60 23 , , , cord-350182-s10nong7 60 24 emphysematous emphysematous JJ cord-350182-s10nong7 60 25 infections infection NNS cord-350182-s10nong7 60 26 of of IN cord-350182-s10nong7 60 27 the the DT cord-350182-s10nong7 60 28 gallbladder gallbladder NN cord-350182-s10nong7 60 29 and and CC cord-350182-s10nong7 60 30 urinary urinary JJ cord-350182-s10nong7 60 31 tract tract NN cord-350182-s10nong7 60 32 , , , cord-350182-s10nong7 60 33 invasive invasive JJ cord-350182-s10nong7 60 34 otitis otitis NN cord-350182-s10nong7 60 35 externa externa NNS cord-350182-s10nong7 60 36 ) ) -RRB- cord-350182-s10nong7 60 37 affect affect VBP cord-350182-s10nong7 60 38 almost almost RB cord-350182-s10nong7 60 39 exclusively exclusively RB cord-350182-s10nong7 60 40 the the DT cord-350182-s10nong7 60 41 diabetic diabetic JJ cord-350182-s10nong7 60 42 population population NN cord-350182-s10nong7 60 43 [ [ -LRB- cord-350182-s10nong7 60 44 22 22 CD cord-350182-s10nong7 60 45 ] ] -RRB- cord-350182-s10nong7 60 46 . . . cord-350182-s10nong7 61 1 Although although IN cord-350182-s10nong7 61 2 the the DT cord-350182-s10nong7 61 3 reasons reason NNS cord-350182-s10nong7 61 4 for for IN cord-350182-s10nong7 61 5 this this DT cord-350182-s10nong7 61 6 vulnerability vulnerability NN cord-350182-s10nong7 61 7 are be VBP cord-350182-s10nong7 61 8 not not RB cord-350182-s10nong7 61 9 completely completely RB cord-350182-s10nong7 61 10 defined define VBN cord-350182-s10nong7 61 11 , , , cord-350182-s10nong7 61 12 it -PRON- PRP cord-350182-s10nong7 61 13 is be VBZ cord-350182-s10nong7 61 14 believed believe VBN cord-350182-s10nong7 61 15 that that IN cord-350182-s10nong7 61 16 abnormalities abnormality NNS cord-350182-s10nong7 61 17 in in IN cord-350182-s10nong7 61 18 innate innate JJ cord-350182-s10nong7 61 19 and and CC cord-350182-s10nong7 61 20 adaptive adaptive JJ cord-350182-s10nong7 61 21 immunity immunity NN cord-350182-s10nong7 61 22 , , , cord-350182-s10nong7 61 23 diminished diminish VBN cord-350182-s10nong7 61 24 vascularisation vascularisation NN cord-350182-s10nong7 61 25 , , , cord-350182-s10nong7 61 26 and and CC cord-350182-s10nong7 61 27 facilitation facilitation NN cord-350182-s10nong7 61 28 of of IN cord-350182-s10nong7 61 29 colonisation colonisation NN cord-350182-s10nong7 61 30 and and CC cord-350182-s10nong7 61 31 growth growth NN cord-350182-s10nong7 61 32 of of IN cord-350182-s10nong7 61 33 a a DT cord-350182-s10nong7 61 34 variety variety NN cord-350182-s10nong7 61 35 of of IN cord-350182-s10nong7 61 36 organisms organism NNS cord-350182-s10nong7 61 37 are be VBP cord-350182-s10nong7 61 38 critical critical JJ cord-350182-s10nong7 61 39 factors factor NNS cord-350182-s10nong7 61 40 [ [ -LRB- cord-350182-s10nong7 61 41 23 23 CD cord-350182-s10nong7 61 42 ] ] -RRB- cord-350182-s10nong7 61 43 . . . cord-350182-s10nong7 62 1 In in IN cord-350182-s10nong7 62 2 case case NN cord-350182-s10nong7 62 3 of of IN cord-350182-s10nong7 62 4 viral viral JJ cord-350182-s10nong7 62 5 infections infection NNS cord-350182-s10nong7 62 6 , , , cord-350182-s10nong7 62 7 it -PRON- PRP cord-350182-s10nong7 62 8 is be VBZ cord-350182-s10nong7 62 9 assumed assume VBN cord-350182-s10nong7 62 10 that that IN cord-350182-s10nong7 62 11 impairments impairment NNS cord-350182-s10nong7 62 12 mainly mainly RB cord-350182-s10nong7 62 13 in in IN cord-350182-s10nong7 62 14 innate innate JJ cord-350182-s10nong7 62 15 as as RB cord-350182-s10nong7 62 16 well well RB cord-350182-s10nong7 62 17 as as IN cord-350182-s10nong7 62 18 in in IN cord-350182-s10nong7 62 19 cell cell NN cord-350182-s10nong7 62 20 - - HYPH cord-350182-s10nong7 62 21 mediated mediate VBN cord-350182-s10nong7 62 22 and and CC cord-350182-s10nong7 62 23 humoral humoral JJ cord-350182-s10nong7 62 24 immunity immunity NN cord-350182-s10nong7 62 25 could could MD cord-350182-s10nong7 62 26 contribute contribute VB cord-350182-s10nong7 62 27 to to IN cord-350182-s10nong7 62 28 the the DT cord-350182-s10nong7 62 29 increased increase VBN cord-350182-s10nong7 62 30 susceptibility susceptibility NN cord-350182-s10nong7 62 31 . . . cord-350182-s10nong7 63 1 The the DT cord-350182-s10nong7 63 2 existence existence NN cord-350182-s10nong7 63 3 of of IN cord-350182-s10nong7 63 4 diabetes diabetes NN cord-350182-s10nong7 63 5 is be VBZ cord-350182-s10nong7 63 6 strongly strongly RB cord-350182-s10nong7 63 7 associated associate VBN cord-350182-s10nong7 63 8 with with IN cord-350182-s10nong7 63 9 an an DT cord-350182-s10nong7 63 10 increased increase VBN cord-350182-s10nong7 63 11 risk risk NN cord-350182-s10nong7 63 12 of of IN cord-350182-s10nong7 63 13 developing develop VBG cord-350182-s10nong7 63 14 severe severe JJ cord-350182-s10nong7 63 15 COVID-19 covid-19 NN cord-350182-s10nong7 63 16 in in IN cord-350182-s10nong7 63 17 case case NN cord-350182-s10nong7 63 18 of of IN cord-350182-s10nong7 63 19 infection infection NN cord-350182-s10nong7 63 20 with with IN cord-350182-s10nong7 63 21 SARS SARS NNP cord-350182-s10nong7 63 22 - - HYPH cord-350182-s10nong7 63 23 CoV-2 CoV-2 NNP cord-350182-s10nong7 63 24 [ [ -LRB- cord-350182-s10nong7 63 25 24 24 CD cord-350182-s10nong7 63 26 , , , cord-350182-s10nong7 63 27 25 25 CD cord-350182-s10nong7 63 28 ] ] -RRB- cord-350182-s10nong7 63 29 . . . cord-350182-s10nong7 64 1 However however RB cord-350182-s10nong7 64 2 , , , cord-350182-s10nong7 64 3 it -PRON- PRP cord-350182-s10nong7 64 4 is be VBZ cord-350182-s10nong7 64 5 not not RB cord-350182-s10nong7 64 6 clear clear JJ cord-350182-s10nong7 64 7 how how WRB cord-350182-s10nong7 64 8 diabetes diabetes NN cord-350182-s10nong7 64 9 mellitus mellitus NN cord-350182-s10nong7 64 10 worsens worsen VBZ cord-350182-s10nong7 64 11 the the DT cord-350182-s10nong7 64 12 clinical clinical JJ cord-350182-s10nong7 64 13 presentation presentation NN cord-350182-s10nong7 64 14 of of IN cord-350182-s10nong7 64 15 COVID-19 COVID-19 NNP cord-350182-s10nong7 64 16 . . . cord-350182-s10nong7 65 1 Several several JJ cord-350182-s10nong7 65 2 suggestions suggestion NNS cord-350182-s10nong7 65 3 can can MD cord-350182-s10nong7 65 4 be be VB cord-350182-s10nong7 65 5 made make VBN cord-350182-s10nong7 65 6 . . . cord-350182-s10nong7 66 1 The the DT cord-350182-s10nong7 66 2 present present JJ cord-350182-s10nong7 66 3 article article NN cord-350182-s10nong7 66 4 supports support VBZ cord-350182-s10nong7 66 5 that that WDT cord-350182-s10nong7 66 6 heightened heighten VBD cord-350182-s10nong7 66 7 inflammatory inflammatory JJ cord-350182-s10nong7 66 8 processes process NNS cord-350182-s10nong7 66 9 constitute constitute VBP cord-350182-s10nong7 66 10 the the DT cord-350182-s10nong7 66 11 main main JJ cord-350182-s10nong7 66 12 pathophysiologic pathophysiologic NN cord-350182-s10nong7 66 13 factor factor NN cord-350182-s10nong7 66 14 for for IN cord-350182-s10nong7 66 15 the the DT cord-350182-s10nong7 66 16 severity severity NN cord-350182-s10nong7 66 17 of of IN cord-350182-s10nong7 66 18 COVID-19 COVID-19 NNP cord-350182-s10nong7 66 19 among among IN cord-350182-s10nong7 66 20 patients patient NNS cord-350182-s10nong7 66 21 with with IN cord-350182-s10nong7 66 22 diabetes diabetes NN cord-350182-s10nong7 66 23 mellitus mellitus NN cord-350182-s10nong7 66 24 , , , cord-350182-s10nong7 66 25 whilst whilst IN cord-350182-s10nong7 66 26 impairments impairment NNS cord-350182-s10nong7 66 27 in in IN cord-350182-s10nong7 66 28 immune immune JJ cord-350182-s10nong7 66 29 response response NN cord-350182-s10nong7 66 30 and and CC cord-350182-s10nong7 66 31 diabetic diabetic JJ cord-350182-s10nong7 66 32 comorbidities comorbiditie NNS cord-350182-s10nong7 66 33 contribute contribute VBP cord-350182-s10nong7 66 34 to to IN cord-350182-s10nong7 66 35 the the DT cord-350182-s10nong7 66 36 aggravated aggravated JJ cord-350182-s10nong7 66 37 pathogenesis pathogenesis NN cord-350182-s10nong7 66 38 . . . cord-350182-s10nong7 67 1 The the DT cord-350182-s10nong7 67 2 primary primary JJ cord-350182-s10nong7 67 3 hypothesis hypothesis NN cord-350182-s10nong7 67 4 is be VBZ cord-350182-s10nong7 67 5 that that DT cord-350182-s10nong7 67 6 chronic chronic JJ cord-350182-s10nong7 67 7 hyperglycaemia hyperglycaemia NN cord-350182-s10nong7 67 8 is be VBZ cord-350182-s10nong7 67 9 involved involve VBN cord-350182-s10nong7 67 10 in in IN cord-350182-s10nong7 67 11 inflammatory inflammatory JJ cord-350182-s10nong7 67 12 processes process NNS cord-350182-s10nong7 67 13 which which WDT cord-350182-s10nong7 67 14 further further RB cord-350182-s10nong7 67 15 activate activate VBP cord-350182-s10nong7 67 16 monocytes monocyte NNS cord-350182-s10nong7 67 17 and and CC cord-350182-s10nong7 67 18 promote promote VB cord-350182-s10nong7 67 19 the the DT cord-350182-s10nong7 67 20 synthesis synthesis NN cord-350182-s10nong7 67 21 of of IN cord-350182-s10nong7 67 22 pro pro JJ cord-350182-s10nong7 67 23 - - JJ cord-350182-s10nong7 67 24 inflammatory inflammatory JJ cord-350182-s10nong7 67 25 cytokines cytokine NNS cord-350182-s10nong7 67 26 , , , cord-350182-s10nong7 67 27 thus thus RB cord-350182-s10nong7 67 28 aggravating aggravate VBG cord-350182-s10nong7 67 29 inflammation inflammation NN cord-350182-s10nong7 67 30 and and CC cord-350182-s10nong7 67 31 injury injury NN cord-350182-s10nong7 67 32 in in IN cord-350182-s10nong7 67 33 the the DT cord-350182-s10nong7 67 34 lung lung NN cord-350182-s10nong7 67 35 tissue tissue NN cord-350182-s10nong7 67 36 and and CC cord-350182-s10nong7 67 37 worsening worsen VBG cord-350182-s10nong7 67 38 clinical clinical JJ cord-350182-s10nong7 67 39 condition condition NN cord-350182-s10nong7 67 40 . . . cord-350182-s10nong7 68 1 In in IN cord-350182-s10nong7 68 2 this this DT cord-350182-s10nong7 68 3 mechanism mechanism NN cord-350182-s10nong7 68 4 , , , cord-350182-s10nong7 68 5 the the DT cord-350182-s10nong7 68 6 excess excess NN cord-350182-s10nong7 68 7 of of IN cord-350182-s10nong7 68 8 circulating circulate VBG cord-350182-s10nong7 68 9 glucose glucose NN cord-350182-s10nong7 68 10 causes cause VBZ cord-350182-s10nong7 68 11 oxidative oxidative JJ cord-350182-s10nong7 68 12 stress stress NN cord-350182-s10nong7 68 13 in in IN cord-350182-s10nong7 68 14 which which WDT cord-350182-s10nong7 68 15 free free JJ cord-350182-s10nong7 68 16 radical radical JJ cord-350182-s10nong7 68 17 O o NN cord-350182-s10nong7 68 18 2 2 CD cord-350182-s10nong7 68 19 reduces reduce VBZ cord-350182-s10nong7 68 20 the the DT cord-350182-s10nong7 68 21 availability availability NN cord-350182-s10nong7 68 22 of of IN cord-350182-s10nong7 68 23 nitric nitric NN cord-350182-s10nong7 68 24 oxide oxide NN cord-350182-s10nong7 68 25 ( ( -LRB- cord-350182-s10nong7 68 26 NO no UH cord-350182-s10nong7 68 27 ) ) -RRB- cord-350182-s10nong7 68 28 and and CC cord-350182-s10nong7 68 29 activates activate VBZ cord-350182-s10nong7 68 30 a a DT cord-350182-s10nong7 68 31 series series NN cord-350182-s10nong7 68 32 of of IN cord-350182-s10nong7 68 33 pro pro JJ cord-350182-s10nong7 68 34 - - JJ cord-350182-s10nong7 68 35 inflammatory inflammatory JJ cord-350182-s10nong7 68 36 transcription transcription NN cord-350182-s10nong7 68 37 factors factor NNS cord-350182-s10nong7 68 38 leading lead VBG cord-350182-s10nong7 68 39 to to IN cord-350182-s10nong7 68 40 inflammation inflammation NN cord-350182-s10nong7 68 41 . . . cord-350182-s10nong7 69 1 Moreover moreover RB cord-350182-s10nong7 69 2 , , , cord-350182-s10nong7 69 3 hyperglycaemia hyperglycaemia NN cord-350182-s10nong7 69 4 increases increase VBZ cord-350182-s10nong7 69 5 the the DT cord-350182-s10nong7 69 6 expression expression NN cord-350182-s10nong7 69 7 of of IN cord-350182-s10nong7 69 8 tumour tumour NN cord-350182-s10nong7 69 9 necrosis necrosis NN cord-350182-s10nong7 69 10 factor factor NN cord-350182-s10nong7 69 11 - - HYPH cord-350182-s10nong7 69 12 alpha alpha NN cord-350182-s10nong7 69 13 ( ( -LRB- cord-350182-s10nong7 69 14 TNF TNF NNP cord-350182-s10nong7 69 15 - - HYPH cord-350182-s10nong7 69 16 a a LS cord-350182-s10nong7 69 17 ) ) -RRB- cord-350182-s10nong7 69 18 and and CC cord-350182-s10nong7 69 19 inteleukin-6 inteleukin-6 NNP cord-350182-s10nong7 69 20 ( ( -LRB- cord-350182-s10nong7 69 21 IL-6 IL-6 NNP cord-350182-s10nong7 69 22 ) ) -RRB- cord-350182-s10nong7 69 23 which which WDT cord-350182-s10nong7 69 24 further further RB cord-350182-s10nong7 69 25 exacerbate exacerbate VBP cord-350182-s10nong7 69 26 inflammation inflammation NN cord-350182-s10nong7 69 27 [ [ -LRB- cord-350182-s10nong7 69 28 26 26 CD cord-350182-s10nong7 69 29 ] ] -RRB- cord-350182-s10nong7 69 30 . . . cord-350182-s10nong7 70 1 A a DT cord-350182-s10nong7 70 2 higher high JJR cord-350182-s10nong7 70 3 propensity propensity NN cord-350182-s10nong7 70 4 to to IN cord-350182-s10nong7 70 5 infections infection NNS cord-350182-s10nong7 70 6 due due JJ cord-350182-s10nong7 70 7 to to IN cord-350182-s10nong7 70 8 the the DT cord-350182-s10nong7 70 9 involvement involvement NN cord-350182-s10nong7 70 10 of of IN cord-350182-s10nong7 70 11 inflammatory inflammatory JJ cord-350182-s10nong7 70 12 processes process NNS cord-350182-s10nong7 70 13 was be VBD cord-350182-s10nong7 70 14 documented document VBN cord-350182-s10nong7 70 15 in in IN cord-350182-s10nong7 70 16 studies study NNS cord-350182-s10nong7 70 17 involving involve VBG cord-350182-s10nong7 70 18 other other JJ cord-350182-s10nong7 70 19 viruses virus NNS cord-350182-s10nong7 70 20 [ [ -LRB- cord-350182-s10nong7 70 21 27 27 CD cord-350182-s10nong7 70 22 ] ] -RRB- cord-350182-s10nong7 70 23 . . . cord-350182-s10nong7 71 1 In in IN cord-350182-s10nong7 71 2 type type NN cord-350182-s10nong7 71 3 1 1 CD cord-350182-s10nong7 71 4 diabetes diabetes NN cord-350182-s10nong7 71 5 , , , cord-350182-s10nong7 71 6 autoimmunity autoimmunity NN cord-350182-s10nong7 71 7 induces induce VBZ cord-350182-s10nong7 71 8 an an DT cord-350182-s10nong7 71 9 inflammatory inflammatory JJ cord-350182-s10nong7 71 10 activity activity NN cord-350182-s10nong7 71 11 which which WDT cord-350182-s10nong7 71 12 leads lead VBZ cord-350182-s10nong7 71 13 to to IN cord-350182-s10nong7 71 14 pancreatic pancreatic NN cord-350182-s10nong7 71 15 β β NN cord-350182-s10nong7 71 16 - - HYPH cord-350182-s10nong7 71 17 cell cell NN cord-350182-s10nong7 71 18 damage damage NN cord-350182-s10nong7 71 19 . . . cord-350182-s10nong7 72 1 The the DT cord-350182-s10nong7 72 2 resultant resultant JJ cord-350182-s10nong7 72 3 chronic chronic NN cord-350182-s10nong7 72 4 hyperglycaemia hyperglycaemia NN cord-350182-s10nong7 72 5 causes cause VBZ cord-350182-s10nong7 72 6 oxidative oxidative JJ cord-350182-s10nong7 72 7 stress stress NN cord-350182-s10nong7 72 8 , , , cord-350182-s10nong7 72 9 increases increase VBZ cord-350182-s10nong7 72 10 the the DT cord-350182-s10nong7 72 11 secretion secretion NN cord-350182-s10nong7 72 12 of of IN cord-350182-s10nong7 72 13 TNF TNF NNP cord-350182-s10nong7 72 14 - - HYPH cord-350182-s10nong7 72 15 α α NNP cord-350182-s10nong7 72 16 and and CC cord-350182-s10nong7 72 17 IL-6 IL-6 NNP cord-350182-s10nong7 72 18 and and CC cord-350182-s10nong7 72 19 impairs impair VBZ cord-350182-s10nong7 72 20 NO no RB cord-350182-s10nong7 72 21 - - HYPH cord-350182-s10nong7 72 22 mediated mediate VBN cord-350182-s10nong7 72 23 vasodilatation vasodilatation NN cord-350182-s10nong7 72 24 [ [ -LRB- cord-350182-s10nong7 72 25 28 28 CD cord-350182-s10nong7 72 26 ] ] -RRB- cord-350182-s10nong7 72 27 . . . cord-350182-s10nong7 73 1 In in IN cord-350182-s10nong7 73 2 type type NN cord-350182-s10nong7 73 3 2 2 CD cord-350182-s10nong7 73 4 diabetes diabetes NN cord-350182-s10nong7 73 5 , , , cord-350182-s10nong7 73 6 inflammation inflammation NN cord-350182-s10nong7 73 7 is be VBZ cord-350182-s10nong7 73 8 also also RB cord-350182-s10nong7 73 9 caused cause VBN cord-350182-s10nong7 73 10 by by IN cord-350182-s10nong7 73 11 systemic systemic JJ cord-350182-s10nong7 73 12 factors factor NNS cord-350182-s10nong7 73 13 , , , cord-350182-s10nong7 73 14 mainly mainly RB cord-350182-s10nong7 73 15 obesity obesity NN cord-350182-s10nong7 73 16 and and CC cord-350182-s10nong7 73 17 subsequently subsequently RB cord-350182-s10nong7 73 18 insulin insulin VBP cord-350182-s10nong7 73 19 resistance resistance NN cord-350182-s10nong7 73 20 . . . cord-350182-s10nong7 74 1 Adipose adipose JJ cord-350182-s10nong7 74 2 tissue tissue NN cord-350182-s10nong7 74 3 enhances enhance VBZ cord-350182-s10nong7 74 4 the the DT cord-350182-s10nong7 74 5 inflammation inflammation NN cord-350182-s10nong7 74 6 process process NN cord-350182-s10nong7 74 7 through through IN cord-350182-s10nong7 74 8 the the DT cord-350182-s10nong7 74 9 action action NN cord-350182-s10nong7 74 10 of of IN cord-350182-s10nong7 74 11 activated activate VBN cord-350182-s10nong7 74 12 macrophages macrophage NNS cord-350182-s10nong7 74 13 and and CC cord-350182-s10nong7 74 14 the the DT cord-350182-s10nong7 74 15 production production NN cord-350182-s10nong7 74 16 of of IN cord-350182-s10nong7 74 17 proinflammatory proinflammatory JJ cord-350182-s10nong7 74 18 cytokines cytokine NNS cord-350182-s10nong7 74 19 ( ( -LRB- cord-350182-s10nong7 74 20 including include VBG cord-350182-s10nong7 74 21 TNF TNF NNP cord-350182-s10nong7 74 22 - - HYPH cord-350182-s10nong7 74 23 a a NNP cord-350182-s10nong7 74 24 and and CC cord-350182-s10nong7 74 25 IL-6 IL-6 NNP cord-350182-s10nong7 74 26 ) ) -RRB- cord-350182-s10nong7 74 27 [ [ -LRB- cord-350182-s10nong7 74 28 29 29 CD cord-350182-s10nong7 74 29 , , , cord-350182-s10nong7 74 30 30 30 CD cord-350182-s10nong7 74 31 ] ] -RRB- cord-350182-s10nong7 74 32 . . . cord-350182-s10nong7 75 1 Yet yet CC cord-350182-s10nong7 75 2 it -PRON- PRP cord-350182-s10nong7 75 3 remains remain VBZ cord-350182-s10nong7 75 4 unclear unclear JJ cord-350182-s10nong7 75 5 whether whether IN cord-350182-s10nong7 75 6 the the DT cord-350182-s10nong7 75 7 innate innate JJ cord-350182-s10nong7 75 8 immune immune JJ cord-350182-s10nong7 75 9 response response NN cord-350182-s10nong7 75 10 is be VBZ cord-350182-s10nong7 75 11 vitally vitally RB cord-350182-s10nong7 75 12 impaired impaired JJ cord-350182-s10nong7 75 13 in in IN cord-350182-s10nong7 75 14 both both DT cord-350182-s10nong7 75 15 types type NNS cord-350182-s10nong7 75 16 of of IN cord-350182-s10nong7 75 17 diabetes diabetes NN cord-350182-s10nong7 75 18 mellitus mellitus NN cord-350182-s10nong7 75 19 and and CC cord-350182-s10nong7 75 20 whether whether IN cord-350182-s10nong7 75 21 hyperglycaemia hyperglycaemia NNP cord-350182-s10nong7 75 22 favours favour VBZ cord-350182-s10nong7 75 23 the the DT cord-350182-s10nong7 75 24 initial initial JJ cord-350182-s10nong7 75 25 virulence virulence NN cord-350182-s10nong7 75 26 of of IN cord-350182-s10nong7 75 27 SARS SARS NNP cord-350182-s10nong7 75 28 - - HYPH cord-350182-s10nong7 75 29 CoV-2 CoV-2 NNP cord-350182-s10nong7 75 30 . . . cord-350182-s10nong7 76 1 Diabetes diabetes NN cord-350182-s10nong7 76 2 is be VBZ cord-350182-s10nong7 76 3 a a DT cord-350182-s10nong7 76 4 chronic chronic JJ cord-350182-s10nong7 76 5 condition condition NN cord-350182-s10nong7 76 6 that that WDT cord-350182-s10nong7 76 7 can can MD cord-350182-s10nong7 76 8 affect affect VB cord-350182-s10nong7 76 9 the the DT cord-350182-s10nong7 76 10 body body NN cord-350182-s10nong7 76 11 's 's POS cord-350182-s10nong7 76 12 immune immune JJ cord-350182-s10nong7 76 13 response response NN cord-350182-s10nong7 76 14 to to IN cord-350182-s10nong7 76 15 pathogens pathogen NNS cord-350182-s10nong7 76 16 [ [ -LRB- cord-350182-s10nong7 76 17 31 31 CD cord-350182-s10nong7 76 18 ] ] -RRB- cord-350182-s10nong7 76 19 . . . cord-350182-s10nong7 77 1 Indeed indeed RB cord-350182-s10nong7 77 2 , , , cord-350182-s10nong7 77 3 the the DT cord-350182-s10nong7 77 4 proliferative proliferative JJ cord-350182-s10nong7 77 5 response response NN cord-350182-s10nong7 77 6 of of IN cord-350182-s10nong7 77 7 lymphocytes lymphocyte NNS cord-350182-s10nong7 77 8 is be VBZ cord-350182-s10nong7 77 9 impaired impair VBN cord-350182-s10nong7 77 10 in in IN cord-350182-s10nong7 77 11 patients patient NNS cord-350182-s10nong7 77 12 with with IN cord-350182-s10nong7 77 13 diabetes diabete NNS cord-350182-s10nong7 77 14 , , , cord-350182-s10nong7 77 15 particularly particularly RB cord-350182-s10nong7 77 16 among among IN cord-350182-s10nong7 77 17 those those DT cord-350182-s10nong7 77 18 with with IN cord-350182-s10nong7 77 19 poor poor JJ cord-350182-s10nong7 77 20 glycaemic glycaemic JJ cord-350182-s10nong7 77 21 control control NN cord-350182-s10nong7 77 22 [ [ -LRB- cord-350182-s10nong7 77 23 32 32 CD cord-350182-s10nong7 77 24 ] ] -RRB- cord-350182-s10nong7 77 25 , , , cord-350182-s10nong7 77 26 and and CC cord-350182-s10nong7 77 27 low low JJ cord-350182-s10nong7 77 28 lymphocyte lymphocyte NN cord-350182-s10nong7 77 29 count count NN cord-350182-s10nong7 77 30 is be VBZ cord-350182-s10nong7 77 31 a a DT cord-350182-s10nong7 77 32 predictor predictor NN cord-350182-s10nong7 77 33 of of IN cord-350182-s10nong7 77 34 severe severe JJ cord-350182-s10nong7 77 35 prognosis prognosis NN cord-350182-s10nong7 77 36 in in IN cord-350182-s10nong7 77 37 patients patient NNS cord-350182-s10nong7 77 38 with with IN cord-350182-s10nong7 77 39 COVID-19 COVID-19 NNP cord-350182-s10nong7 77 40 [ [ -LRB- cord-350182-s10nong7 77 41 33 33 CD cord-350182-s10nong7 77 42 ] ] -RRB- cord-350182-s10nong7 77 43 . . . cord-350182-s10nong7 78 1 With with IN cord-350182-s10nong7 78 2 regard regard NN cord-350182-s10nong7 78 3 to to IN cord-350182-s10nong7 78 4 the the DT cord-350182-s10nong7 78 5 production production NN cord-350182-s10nong7 78 6 of of IN cord-350182-s10nong7 78 7 neutralising neutralise VBG cord-350182-s10nong7 78 8 antibodies antibody NNS cord-350182-s10nong7 78 9 , , , cord-350182-s10nong7 78 10 it -PRON- PRP cord-350182-s10nong7 78 11 is be VBZ cord-350182-s10nong7 78 12 possible possible JJ cord-350182-s10nong7 78 13 that that IN cord-350182-s10nong7 78 14 glycosylation glycosylation NN cord-350182-s10nong7 78 15 may may MD cord-350182-s10nong7 78 16 impair impair VB cord-350182-s10nong7 78 17 humoral humoral JJ cord-350182-s10nong7 78 18 immunity immunity NN cord-350182-s10nong7 78 19 , , , cord-350182-s10nong7 78 20 especially especially RB cord-350182-s10nong7 78 21 in in IN cord-350182-s10nong7 78 22 patients patient NNS cord-350182-s10nong7 78 23 with with IN cord-350182-s10nong7 78 24 high high JJ cord-350182-s10nong7 78 25 HbA HbA NNP cord-350182-s10nong7 78 26 1c 1c CD cord-350182-s10nong7 78 27 values value NNS cord-350182-s10nong7 78 28 [ [ -LRB- cord-350182-s10nong7 78 29 34 34 CD cord-350182-s10nong7 78 30 ] ] -RRB- cord-350182-s10nong7 78 31 . . . cord-350182-s10nong7 79 1 Furthermore furthermore RB cord-350182-s10nong7 79 2 , , , cord-350182-s10nong7 79 3 patients patient NNS cord-350182-s10nong7 79 4 with with IN cord-350182-s10nong7 79 5 diabetes diabetes NN cord-350182-s10nong7 79 6 mellitus mellitus NN cord-350182-s10nong7 79 7 may may MD cord-350182-s10nong7 79 8 present present VB cord-350182-s10nong7 79 9 dysfunctional dysfunctional JJ cord-350182-s10nong7 79 10 type type NN cord-350182-s10nong7 79 11 IV IV NNP cord-350182-s10nong7 79 12 ( ( -LRB- cord-350182-s10nong7 79 13 delayed delay VBN cord-350182-s10nong7 79 14 ) ) -RRB- cord-350182-s10nong7 79 15 hypersensitivity hypersensitivity NN cord-350182-s10nong7 79 16 reaction reaction NN cord-350182-s10nong7 79 17 and and CC cord-350182-s10nong7 79 18 abnormal abnormal JJ cord-350182-s10nong7 79 19 complement complement NN cord-350182-s10nong7 79 20 activation activation NN cord-350182-s10nong7 79 21 [ [ -LRB- cord-350182-s10nong7 79 22 35 35 CD cord-350182-s10nong7 79 23 ] ] -RRB- cord-350182-s10nong7 79 24 which which WDT cord-350182-s10nong7 79 25 may may MD cord-350182-s10nong7 79 26 hinder hinder VB cord-350182-s10nong7 79 27 the the DT cord-350182-s10nong7 79 28 immune immune JJ cord-350182-s10nong7 79 29 response response NN cord-350182-s10nong7 79 30 . . . cord-350182-s10nong7 80 1 Apart apart RB cord-350182-s10nong7 80 2 from from IN cord-350182-s10nong7 80 3 the the DT cord-350182-s10nong7 80 4 defects defect NNS cord-350182-s10nong7 80 5 in in IN cord-350182-s10nong7 80 6 inflammatory inflammatory JJ cord-350182-s10nong7 80 7 and and CC cord-350182-s10nong7 80 8 immune immune JJ cord-350182-s10nong7 80 9 functions function NNS cord-350182-s10nong7 80 10 due due IN cord-350182-s10nong7 80 11 to to IN cord-350182-s10nong7 80 12 hyperglycaemia hyperglycaemia NN cord-350182-s10nong7 80 13 , , , cord-350182-s10nong7 80 14 complications complication NNS cord-350182-s10nong7 80 15 of of IN cord-350182-s10nong7 80 16 diabetes diabetes NN cord-350182-s10nong7 80 17 mellitus mellitus NN cord-350182-s10nong7 80 18 and and CC cord-350182-s10nong7 80 19 treatment treatment NN cord-350182-s10nong7 80 20 regimens regimen NNS cord-350182-s10nong7 80 21 may may MD cord-350182-s10nong7 80 22 be be VB cord-350182-s10nong7 80 23 involved involve VBN cord-350182-s10nong7 80 24 in in IN cord-350182-s10nong7 80 25 the the DT cord-350182-s10nong7 80 26 vulnerability vulnerability NN cord-350182-s10nong7 80 27 of of IN cord-350182-s10nong7 80 28 these these DT cord-350182-s10nong7 80 29 patients patient NNS cord-350182-s10nong7 80 30 . . . cord-350182-s10nong7 81 1 Endothelial endothelial JJ cord-350182-s10nong7 81 2 dysfunction dysfunction NN cord-350182-s10nong7 81 3 , , , cord-350182-s10nong7 81 4 in in IN cord-350182-s10nong7 81 5 particular particular JJ cord-350182-s10nong7 81 6 , , , cord-350182-s10nong7 81 7 may may MD cord-350182-s10nong7 81 8 enable enable VB cord-350182-s10nong7 81 9 SASR SASR NNP cord-350182-s10nong7 81 10 - - HYPH cord-350182-s10nong7 81 11 CoV-2 CoV-2 NNP cord-350182-s10nong7 81 12 to to TO cord-350182-s10nong7 81 13 have have VB cord-350182-s10nong7 81 14 an an DT cord-350182-s10nong7 81 15 easier easy JJR cord-350182-s10nong7 81 16 access access NN cord-350182-s10nong7 81 17 to to IN cord-350182-s10nong7 81 18 host host NN cord-350182-s10nong7 81 19 cells cell NNS cord-350182-s10nong7 81 20 [ [ -LRB- cord-350182-s10nong7 81 21 36 36 CD cord-350182-s10nong7 81 22 ] ] -RRB- cord-350182-s10nong7 81 23 . . . cord-350182-s10nong7 82 1 In in IN cord-350182-s10nong7 82 2 addition addition NN cord-350182-s10nong7 82 3 , , , cord-350182-s10nong7 82 4 associated associate VBN cord-350182-s10nong7 82 5 diabetic diabetic JJ cord-350182-s10nong7 82 6 comorbidities comorbiditie NNS cord-350182-s10nong7 82 7 and/ and/ NNP cord-350182-s10nong7 82 8 or or CC cord-350182-s10nong7 82 9 complications complication NNS cord-350182-s10nong7 82 10 , , , cord-350182-s10nong7 82 11 such such JJ cord-350182-s10nong7 82 12 as as IN cord-350182-s10nong7 82 13 hypertension hypertension NN cord-350182-s10nong7 82 14 , , , cord-350182-s10nong7 82 15 cardiovascular cardiovascular JJ cord-350182-s10nong7 82 16 disease disease NN cord-350182-s10nong7 82 17 , , , cord-350182-s10nong7 82 18 and and CC cord-350182-s10nong7 82 19 chronic chronic JJ cord-350182-s10nong7 82 20 kidney kidney NN cord-350182-s10nong7 82 21 disease disease NN cord-350182-s10nong7 82 22 may may MD cord-350182-s10nong7 82 23 act act VB cord-350182-s10nong7 82 24 synergistically synergistically RB cord-350182-s10nong7 82 25 and and CC cord-350182-s10nong7 82 26 further further RB cord-350182-s10nong7 82 27 worsen worsen VB cord-350182-s10nong7 82 28 the the DT cord-350182-s10nong7 82 29 prognosis prognosis NN cord-350182-s10nong7 82 30 [ [ -LRB- cord-350182-s10nong7 82 31 37 37 CD cord-350182-s10nong7 82 32 ] ] -RRB- cord-350182-s10nong7 82 33 . . . cord-350182-s10nong7 83 1 Especially especially RB cord-350182-s10nong7 83 2 persons person NNS cord-350182-s10nong7 83 3 , , , cord-350182-s10nong7 83 4 who who WP cord-350182-s10nong7 83 5 are be VBP cord-350182-s10nong7 83 6 treated treat VBN cord-350182-s10nong7 83 7 with with IN cord-350182-s10nong7 83 8 ACE ACE NNP cord-350182-s10nong7 83 9 inhibitors inhibitor NNS cord-350182-s10nong7 83 10 or or CC cord-350182-s10nong7 83 11 angiotensin angiotensin NN cord-350182-s10nong7 83 12 2 2 CD cord-350182-s10nong7 83 13 receptor receptor NN cord-350182-s10nong7 83 14 blockers blocker NNS cord-350182-s10nong7 83 15 , , , cord-350182-s10nong7 83 16 have have VBP cord-350182-s10nong7 83 17 increased increase VBN cord-350182-s10nong7 83 18 expression expression NN cord-350182-s10nong7 83 19 of of IN cord-350182-s10nong7 83 20 ACE2 ACE2 NNP cord-350182-s10nong7 83 21 which which WDT cord-350182-s10nong7 83 22 could could MD cord-350182-s10nong7 83 23 potentially potentially RB cord-350182-s10nong7 83 24 facilitate facilitate VB cord-350182-s10nong7 83 25 the the DT cord-350182-s10nong7 83 26 infection infection NN cord-350182-s10nong7 83 27 with with IN cord-350182-s10nong7 83 28 SARS SARS NNP cord-350182-s10nong7 83 29 - - HYPH cord-350182-s10nong7 83 30 CoV-2 CoV-2 NNP cord-350182-s10nong7 83 31 [ [ -LRB- cord-350182-s10nong7 83 32 38 38 CD cord-350182-s10nong7 83 33 ] ] -RRB- cord-350182-s10nong7 83 34 . . . cord-350182-s10nong7 84 1 COVID-19 COVID-19 NNP cord-350182-s10nong7 84 2 has have VBZ cord-350182-s10nong7 84 3 evolved evolve VBN cord-350182-s10nong7 84 4 to to IN cord-350182-s10nong7 84 5 a a DT cord-350182-s10nong7 84 6 public public JJ cord-350182-s10nong7 84 7 health health NN cord-350182-s10nong7 84 8 crisis crisis NN cord-350182-s10nong7 84 9 . . . cord-350182-s10nong7 85 1 Currently currently RB cord-350182-s10nong7 85 2 , , , cord-350182-s10nong7 85 3 there there EX cord-350182-s10nong7 85 4 is be VBZ cord-350182-s10nong7 85 5 a a DT cord-350182-s10nong7 85 6 lack lack NN cord-350182-s10nong7 85 7 of of IN cord-350182-s10nong7 85 8 specific specific JJ cord-350182-s10nong7 85 9 treatments treatment NNS cord-350182-s10nong7 85 10 , , , cord-350182-s10nong7 85 11 and and CC cord-350182-s10nong7 85 12 only only RB cord-350182-s10nong7 85 13 general general JJ cord-350182-s10nong7 85 14 preventive preventive JJ cord-350182-s10nong7 85 15 strategies strategy NNS cord-350182-s10nong7 85 16 are be VBP cord-350182-s10nong7 85 17 available available JJ cord-350182-s10nong7 85 18 . . . cord-350182-s10nong7 86 1 Within within IN cord-350182-s10nong7 86 2 this this DT cord-350182-s10nong7 86 3 context context NN cord-350182-s10nong7 86 4 , , , cord-350182-s10nong7 86 5 appropriate appropriate JJ cord-350182-s10nong7 86 6 guidance guidance NN cord-350182-s10nong7 86 7 of of IN cord-350182-s10nong7 86 8 patients patient NNS cord-350182-s10nong7 86 9 with with IN cord-350182-s10nong7 86 10 diabetes diabetes NN cord-350182-s10nong7 86 11 should should MD cord-350182-s10nong7 86 12 be be VB cord-350182-s10nong7 86 13 a a DT cord-350182-s10nong7 86 14 priority priority NN cord-350182-s10nong7 86 15 . . . cord-350182-s10nong7 87 1 Social social JJ cord-350182-s10nong7 87 2 distancing distancing NN cord-350182-s10nong7 87 3 and and CC cord-350182-s10nong7 87 4 practicing practice VBG cord-350182-s10nong7 87 5 good good JJ cord-350182-s10nong7 87 6 hygiene hygiene NN cord-350182-s10nong7 87 7 are be VBP cord-350182-s10nong7 87 8 invaluable invaluable JJ cord-350182-s10nong7 87 9 tools tool NNS cord-350182-s10nong7 87 10 for for IN cord-350182-s10nong7 87 11 diminishing diminish VBG cord-350182-s10nong7 87 12 the the DT cord-350182-s10nong7 87 13 transmission transmission NN cord-350182-s10nong7 87 14 of of IN cord-350182-s10nong7 87 15 SARS SARS NNP cord-350182-s10nong7 87 16 - - HYPH cord-350182-s10nong7 87 17 CoV-2 CoV-2 NNP cord-350182-s10nong7 87 18 . . . cord-350182-s10nong7 88 1 In in IN cord-350182-s10nong7 88 2 case case NN cord-350182-s10nong7 88 3 of of IN cord-350182-s10nong7 88 4 extended extended JJ cord-350182-s10nong7 88 5 periods period NNS cord-350182-s10nong7 88 6 of of IN cord-350182-s10nong7 88 7 isolation isolation NN cord-350182-s10nong7 88 8 , , , cord-350182-s10nong7 88 9 individuals individual NNS cord-350182-s10nong7 88 10 with with IN cord-350182-s10nong7 88 11 diabetes diabetes NN cord-350182-s10nong7 88 12 should should MD cord-350182-s10nong7 88 13 secure secure VB cord-350182-s10nong7 88 14 access access NN cord-350182-s10nong7 88 15 to to IN cord-350182-s10nong7 88 16 medications medication NNS cord-350182-s10nong7 88 17 and and CC cord-350182-s10nong7 88 18 consumable consumable JJ cord-350182-s10nong7 88 19 supplies supply NNS cord-350182-s10nong7 88 20 , , , cord-350182-s10nong7 88 21 such such JJ cord-350182-s10nong7 88 22 as as IN cord-350182-s10nong7 88 23 insulin insulin NN cord-350182-s10nong7 88 24 , , , cord-350182-s10nong7 88 25 glucose glucose NN cord-350182-s10nong7 88 26 test test NN cord-350182-s10nong7 88 27 strips strip NNS cord-350182-s10nong7 88 28 , , , cord-350182-s10nong7 88 29 disinfectants disinfectant NNS cord-350182-s10nong7 88 30 , , , cord-350182-s10nong7 88 31 and and CC cord-350182-s10nong7 88 32 ensure ensure VB cord-350182-s10nong7 88 33 unimpeded unimpeded JJ cord-350182-s10nong7 88 34 communication communication NN cord-350182-s10nong7 88 35 with with IN cord-350182-s10nong7 88 36 health health NN cord-350182-s10nong7 88 37 care care NN cord-350182-s10nong7 88 38 professionals professional NNS cord-350182-s10nong7 88 39 , , , cord-350182-s10nong7 88 40 including include VBG cord-350182-s10nong7 88 41 the the DT cord-350182-s10nong7 88 42 use use NN cord-350182-s10nong7 88 43 of of IN cord-350182-s10nong7 88 44 phone phone NN cord-350182-s10nong7 88 45 and and CC cord-350182-s10nong7 88 46 video video NN cord-350182-s10nong7 88 47 calls call NNS cord-350182-s10nong7 88 48 to to TO cord-350182-s10nong7 88 49 minimise minimise VB cord-350182-s10nong7 88 50 face face NN cord-350182-s10nong7 88 51 - - HYPH cord-350182-s10nong7 88 52 to to IN cord-350182-s10nong7 88 53 - - HYPH cord-350182-s10nong7 88 54 face face NN cord-350182-s10nong7 88 55 contact contact NN cord-350182-s10nong7 88 56 [ [ -LRB- cord-350182-s10nong7 88 57 39 39 CD cord-350182-s10nong7 88 58 ] ] -RRB- cord-350182-s10nong7 88 59 . . . cord-350182-s10nong7 89 1 Although although IN cord-350182-s10nong7 89 2 individuals individual NNS cord-350182-s10nong7 89 3 with with IN cord-350182-s10nong7 89 4 diabetes diabete NNS cord-350182-s10nong7 89 5 do do VBP cord-350182-s10nong7 89 6 not not RB cord-350182-s10nong7 89 7 appear appear VB cord-350182-s10nong7 89 8 to to TO cord-350182-s10nong7 89 9 contract contract VB cord-350182-s10nong7 89 10 SARS SARS NNP cord-350182-s10nong7 89 11 - - HYPH cord-350182-s10nong7 89 12 CoV-2 CoV-2 NNP cord-350182-s10nong7 89 13 at at IN cord-350182-s10nong7 89 14 an an DT cord-350182-s10nong7 89 15 increased increase VBN cord-350182-s10nong7 89 16 rate rate NN cord-350182-s10nong7 89 17 compared compare VBN cord-350182-s10nong7 89 18 to to IN cord-350182-s10nong7 89 19 the the DT cord-350182-s10nong7 89 20 general general JJ cord-350182-s10nong7 89 21 population population NN cord-350182-s10nong7 89 22 [ [ -LRB- cord-350182-s10nong7 89 23 40 40 CD cord-350182-s10nong7 89 24 ] ] -RRB- cord-350182-s10nong7 89 25 , , , cord-350182-s10nong7 89 26 poor poor JJ cord-350182-s10nong7 89 27 control control NN cord-350182-s10nong7 89 28 of of IN cord-350182-s10nong7 89 29 diabetes diabetes NN cord-350182-s10nong7 89 30 is be VBZ cord-350182-s10nong7 89 31 associated associate VBN cord-350182-s10nong7 89 32 with with IN cord-350182-s10nong7 89 33 a a DT cord-350182-s10nong7 89 34 higher high JJR cord-350182-s10nong7 89 35 risk risk NN cord-350182-s10nong7 89 36 for for IN cord-350182-s10nong7 89 37 adverse adverse JJ cord-350182-s10nong7 89 38 clinical clinical JJ cord-350182-s10nong7 89 39 outcomes outcome NNS cord-350182-s10nong7 89 40 . . . cord-350182-s10nong7 90 1 Therefore therefore RB cord-350182-s10nong7 90 2 , , , cord-350182-s10nong7 90 3 it -PRON- PRP cord-350182-s10nong7 90 4 is be VBZ cord-350182-s10nong7 90 5 important important JJ cord-350182-s10nong7 90 6 that that IN cord-350182-s10nong7 90 7 persons person NNS cord-350182-s10nong7 90 8 with with IN cord-350182-s10nong7 90 9 diabetes diabetes NN cord-350182-s10nong7 90 10 mellitus mellitus NN cord-350182-s10nong7 90 11 maintain maintain VBP cord-350182-s10nong7 90 12 an an DT cord-350182-s10nong7 90 13 optimal optimal JJ cord-350182-s10nong7 90 14 glycaemic glycaemic JJ cord-350182-s10nong7 90 15 control control NN cord-350182-s10nong7 90 16 during during IN cord-350182-s10nong7 90 17 a a DT cord-350182-s10nong7 90 18 SARS SARS NNP cord-350182-s10nong7 90 19 - - HYPH cord-350182-s10nong7 90 20 CoV-2 CoV-2 NNP cord-350182-s10nong7 90 21 outbreak outbreak NN cord-350182-s10nong7 90 22 . . . cord-350182-s10nong7 91 1 Regular regular JJ cord-350182-s10nong7 91 2 monitoring monitoring NN cord-350182-s10nong7 91 3 of of IN cord-350182-s10nong7 91 4 blood blood NN cord-350182-s10nong7 91 5 glucose glucose NN cord-350182-s10nong7 91 6 levels level NNS cord-350182-s10nong7 91 7 ( ( -LRB- cord-350182-s10nong7 91 8 and and CC cord-350182-s10nong7 91 9 urinary urinary JJ cord-350182-s10nong7 91 10 ketones ketone NNS cord-350182-s10nong7 91 11 when when WRB cord-350182-s10nong7 91 12 needed need VBN cord-350182-s10nong7 91 13 ) ) -RRB- cord-350182-s10nong7 91 14 and and CC cord-350182-s10nong7 91 15 adherence adherence NN cord-350182-s10nong7 91 16 to to IN cord-350182-s10nong7 91 17 treatment treatment NN cord-350182-s10nong7 91 18 are be VBP cord-350182-s10nong7 91 19 necessary necessary JJ cord-350182-s10nong7 91 20 for for IN cord-350182-s10nong7 91 21 this this DT cord-350182-s10nong7 91 22 purpose purpose NN cord-350182-s10nong7 91 23 . . . cord-350182-s10nong7 92 1 Attention attention NN cord-350182-s10nong7 92 2 to to IN cord-350182-s10nong7 92 3 proper proper JJ cord-350182-s10nong7 92 4 nutrition nutrition NN cord-350182-s10nong7 92 5 and and CC cord-350182-s10nong7 92 6 physical physical JJ cord-350182-s10nong7 92 7 activity activity NN cord-350182-s10nong7 92 8 ( ( -LRB- cord-350182-s10nong7 92 9 such such JJ cord-350182-s10nong7 92 10 as as IN cord-350182-s10nong7 92 11 indoor indoor JJ cord-350182-s10nong7 92 12 exercise exercise NN cord-350182-s10nong7 92 13 and and CC cord-350182-s10nong7 92 14 unescorted unescorted JJ cord-350182-s10nong7 92 15 walking walking NN cord-350182-s10nong7 92 16 ) ) -RRB- cord-350182-s10nong7 92 17 are be VBP cord-350182-s10nong7 92 18 also also RB cord-350182-s10nong7 92 19 important important JJ cord-350182-s10nong7 92 20 [ [ -LRB- cord-350182-s10nong7 92 21 41 41 CD cord-350182-s10nong7 92 22 ] ] -RRB- cord-350182-s10nong7 92 23 . . . cord-350182-s10nong7 93 1 The the DT cord-350182-s10nong7 93 2 health health NN cord-350182-s10nong7 93 3 crisis crisis NN cord-350182-s10nong7 93 4 due due IN cord-350182-s10nong7 93 5 to to IN cord-350182-s10nong7 93 6 the the DT cord-350182-s10nong7 93 7 COVID-19 COVID-19 NNP cord-350182-s10nong7 93 8 pandemic pandemic NN cord-350182-s10nong7 93 9 has have VBZ cord-350182-s10nong7 93 10 been be VBN cord-350182-s10nong7 93 11 a a DT cord-350182-s10nong7 93 12 global global JJ cord-350182-s10nong7 93 13 challenge challenge NN cord-350182-s10nong7 93 14 for for IN cord-350182-s10nong7 93 15 states state NNS cord-350182-s10nong7 93 16 , , , cord-350182-s10nong7 93 17 care care VB cord-350182-s10nong7 93 18 systems system NNS cord-350182-s10nong7 93 19 and and CC cord-350182-s10nong7 93 20 individuals individual NNS cord-350182-s10nong7 93 21 . . . cord-350182-s10nong7 94 1 SARS SARS NNP cord-350182-s10nong7 94 2 - - HYPH cord-350182-s10nong7 94 3 CoV-2 CoV-2 NNP cord-350182-s10nong7 94 4 has have VBZ cord-350182-s10nong7 94 5 been be VBN cord-350182-s10nong7 94 6 exceptionally exceptionally RB cord-350182-s10nong7 94 7 infectious infectious JJ cord-350182-s10nong7 94 8 and and CC cord-350182-s10nong7 94 9 pathogenic pathogenic JJ cord-350182-s10nong7 94 10 for for IN cord-350182-s10nong7 94 11 humans human NNS cord-350182-s10nong7 94 12 . . . cord-350182-s10nong7 95 1 Patients patient NNS cord-350182-s10nong7 95 2 with with IN cord-350182-s10nong7 95 3 diabetes diabetes NN cord-350182-s10nong7 95 4 mellitus mellitus NN cord-350182-s10nong7 95 5 need need VBP cord-350182-s10nong7 95 6 to to TO cord-350182-s10nong7 95 7 be be VB cord-350182-s10nong7 95 8 in in IN cord-350182-s10nong7 95 9 the the DT cord-350182-s10nong7 95 10 core core NN cord-350182-s10nong7 95 11 of of IN cord-350182-s10nong7 95 12 health health NN cord-350182-s10nong7 95 13 care care NN cord-350182-s10nong7 95 14 attention attention NN cord-350182-s10nong7 95 15 because because IN cord-350182-s10nong7 95 16 of of IN cord-350182-s10nong7 95 17 greater great JJR cord-350182-s10nong7 95 18 risk risk NN cord-350182-s10nong7 95 19 for for IN cord-350182-s10nong7 95 20 severe severe JJ cord-350182-s10nong7 95 21 clinical clinical JJ cord-350182-s10nong7 95 22 course course NN cord-350182-s10nong7 95 23 and and CC cord-350182-s10nong7 95 24 mortality mortality NN cord-350182-s10nong7 95 25 . . . cord-350182-s10nong7 96 1 In in IN cord-350182-s10nong7 96 2 addition addition NN cord-350182-s10nong7 96 3 , , , cord-350182-s10nong7 96 4 the the DT cord-350182-s10nong7 96 5 global global JJ cord-350182-s10nong7 96 6 community community NN cord-350182-s10nong7 96 7 should should MD cord-350182-s10nong7 96 8 focus focus VB cord-350182-s10nong7 96 9 on on IN cord-350182-s10nong7 96 10 the the DT cord-350182-s10nong7 96 11 discovery discovery NN cord-350182-s10nong7 96 12 and and CC cord-350182-s10nong7 96 13 production production NN cord-350182-s10nong7 96 14 of of IN cord-350182-s10nong7 96 15 the the DT cord-350182-s10nong7 96 16 medical medical JJ cord-350182-s10nong7 96 17 means mean NNS cord-350182-s10nong7 96 18 that that WDT cord-350182-s10nong7 96 19 will will MD cord-350182-s10nong7 96 20 affectively affectively RB cord-350182-s10nong7 96 21 protect protect VB cord-350182-s10nong7 96 22 populations population NNS cord-350182-s10nong7 96 23 . . . cord-350182-s10nong7 97 1 Identification identification NN cord-350182-s10nong7 97 2 of of IN cord-350182-s10nong7 97 3 a a DT cord-350182-s10nong7 97 4 novel novel JJ cord-350182-s10nong7 97 5 coronavirus coronavirus NN cord-350182-s10nong7 97 6 causing cause VBG cord-350182-s10nong7 97 7 severe severe JJ cord-350182-s10nong7 97 8 pneumonia pneumonia NN cord-350182-s10nong7 97 9 in in IN cord-350182-s10nong7 97 10 human human NN cord-350182-s10nong7 97 11 : : : cord-350182-s10nong7 98 1 A a DT cord-350182-s10nong7 98 2 descriptive descriptive JJ cord-350182-s10nong7 98 3 study study NN cord-350182-s10nong7 99 1 Structural structural JJ cord-350182-s10nong7 99 2 basis basis NN cord-350182-s10nong7 99 3 for for IN cord-350182-s10nong7 99 4 the the DT cord-350182-s10nong7 99 5 recognition recognition NN cord-350182-s10nong7 99 6 of of IN cord-350182-s10nong7 99 7 SARS SARS NNP cord-350182-s10nong7 99 8 - - HYPH cord-350182-s10nong7 99 9 CoV-2 CoV-2 NNP cord-350182-s10nong7 99 10 by by IN cord-350182-s10nong7 99 11 full full JJ cord-350182-s10nong7 99 12 - - HYPH cord-350182-s10nong7 99 13 length length NN cord-350182-s10nong7 99 14 human human JJ cord-350182-s10nong7 99 15 ACE2 ACE2 NNP cord-350182-s10nong7 99 16 Zoonotic Zoonotic NNP cord-350182-s10nong7 99 17 origins origin NNS cord-350182-s10nong7 99 18 of of IN cord-350182-s10nong7 99 19 human human JJ cord-350182-s10nong7 99 20 coronaviruses coronaviruse NNS cord-350182-s10nong7 100 1 The the DT cord-350182-s10nong7 100 2 epidemiology epidemiology NN cord-350182-s10nong7 100 3 and and CC cord-350182-s10nong7 100 4 pathogenesis pathogenesis NN cord-350182-s10nong7 100 5 of of IN cord-350182-s10nong7 100 6 coronavirus coronavirus NN cord-350182-s10nong7 100 7 disease disease NN cord-350182-s10nong7 100 8 ( ( -LRB- cord-350182-s10nong7 100 9 COVID-19 COVID-19 NNP cord-350182-s10nong7 100 10 ) ) -RRB- cord-350182-s10nong7 100 11 outbreak outbreak NN cord-350182-s10nong7 101 1 The the DT cord-350182-s10nong7 101 2 incubation incubation NN cord-350182-s10nong7 101 3 period period NN cord-350182-s10nong7 101 4 of of IN cord-350182-s10nong7 101 5 coronavirus coronavirus NN cord-350182-s10nong7 101 6 disease disease NN cord-350182-s10nong7 101 7 2019 2019 CD cord-350182-s10nong7 101 8 ( ( -LRB- cord-350182-s10nong7 101 9 COVID-19 COVID-19 NNP cord-350182-s10nong7 101 10 ) ) -RRB- cord-350182-s10nong7 101 11 from from IN cord-350182-s10nong7 101 12 publicly publicly RB cord-350182-s10nong7 101 13 reported report VBN cord-350182-s10nong7 101 14 confirmed confirm VBN cord-350182-s10nong7 101 15 cases case NNS cord-350182-s10nong7 101 16 : : : cord-350182-s10nong7 101 17 Estimation estimation NN cord-350182-s10nong7 101 18 and and CC cord-350182-s10nong7 101 19 application application NN cord-350182-s10nong7 101 20 High high JJ cord-350182-s10nong7 101 21 contagiousness contagiousness NN cord-350182-s10nong7 101 22 and and CC cord-350182-s10nong7 101 23 rapid rapid JJ cord-350182-s10nong7 101 24 spread spread NN cord-350182-s10nong7 101 25 of of IN cord-350182-s10nong7 101 26 severe severe JJ cord-350182-s10nong7 101 27 acute acute JJ cord-350182-s10nong7 101 28 respiratory respiratory JJ cord-350182-s10nong7 101 29 syndrome syndrome NN cord-350182-s10nong7 101 30 coronavirus coronavirus NN cord-350182-s10nong7 101 31 2 2 CD cord-350182-s10nong7 102 1 Di Di NNP cord-350182-s10nong7 102 2 Napoli Napoli NNP cord-350182-s10nong7 102 3 R. R. NNP cord-350182-s10nong7 102 4 Features Features NNP cord-350182-s10nong7 102 5 , , , cord-350182-s10nong7 102 6 evaluation evaluation NN cord-350182-s10nong7 102 7 and and CC cord-350182-s10nong7 102 8 treatment treatment NN cord-350182-s10nong7 102 9 Coronavirus Coronavirus NNP cord-350182-s10nong7 102 10 Prevalence prevalence NN cord-350182-s10nong7 102 11 of of IN cord-350182-s10nong7 102 12 underlying underlie VBG cord-350182-s10nong7 102 13 diseases disease NNS cord-350182-s10nong7 102 14 in in IN cord-350182-s10nong7 102 15 hospitalized hospitalize VBN cord-350182-s10nong7 102 16 patients patient NNS cord-350182-s10nong7 102 17 with with IN cord-350182-s10nong7 102 18 COVID-19 covid-19 CD cord-350182-s10nong7 102 19 : : : cord-350182-s10nong7 102 20 A a DT cord-350182-s10nong7 102 21 systematic systematic JJ cord-350182-s10nong7 102 22 review review NN cord-350182-s10nong7 102 23 and and CC cord-350182-s10nong7 102 24 meta meta NNP cord-350182-s10nong7 102 25 - - HYPH cord-350182-s10nong7 102 26 analysis analysis NNP cord-350182-s10nong7 102 27 Structure Structure NNP cord-350182-s10nong7 102 28 , , , cord-350182-s10nong7 102 29 function function NN cord-350182-s10nong7 102 30 , , , cord-350182-s10nong7 102 31 and and CC cord-350182-s10nong7 102 32 antigenicity antigenicity NN cord-350182-s10nong7 102 33 of of IN cord-350182-s10nong7 102 34 the the DT cord-350182-s10nong7 102 35 SARS SARS NNP cord-350182-s10nong7 102 36 - - HYPH cord-350182-s10nong7 102 37 CoV-2 CoV-2 NNP cord-350182-s10nong7 102 38 spike spike NN cord-350182-s10nong7 102 39 glycoprotein glycoprotein NN cord-350182-s10nong7 102 40 China China NNP cord-350182-s10nong7 102 41 Novel Novel NNP cord-350182-s10nong7 102 42 Coronavirus Coronavirus NNP cord-350182-s10nong7 102 43 Investigating Investigating NNP cord-350182-s10nong7 102 44 and and CC cord-350182-s10nong7 102 45 Research Research NNP cord-350182-s10nong7 102 46 Team Team NNP cord-350182-s10nong7 102 47 . . . cord-350182-s10nong7 103 1 A a DT cord-350182-s10nong7 103 2 novel novel JJ cord-350182-s10nong7 103 3 coronavirus coronavirus NN cord-350182-s10nong7 103 4 from from IN cord-350182-s10nong7 103 5 patients patient NNS cord-350182-s10nong7 103 6 with with IN cord-350182-s10nong7 103 7 pneumonia pneumonia NN cord-350182-s10nong7 103 8 in in IN cord-350182-s10nong7 103 9 China China NNP cord-350182-s10nong7 104 1 Interferon interferon NN cord-350182-s10nong7 104 2 and and CC cord-350182-s10nong7 104 3 cytokine cytokine JJ cord-350182-s10nong7 104 4 responses response NNS cord-350182-s10nong7 104 5 to to IN cord-350182-s10nong7 104 6 SARScoronavirus SARScoronavirus NNP cord-350182-s10nong7 104 7 infection infection NN cord-350182-s10nong7 104 8 Immune Immune NNP cord-350182-s10nong7 104 9 responses response NNS cord-350182-s10nong7 104 10 in in IN cord-350182-s10nong7 104 11 COVID-19 covid-19 JJ cord-350182-s10nong7 104 12 and and CC cord-350182-s10nong7 104 13 potential potential JJ cord-350182-s10nong7 104 14 vaccines vaccine NNS cord-350182-s10nong7 104 15 : : : cord-350182-s10nong7 104 16 Lessons lesson NNS cord-350182-s10nong7 104 17 learned learn VBN cord-350182-s10nong7 104 18 from from IN cord-350182-s10nong7 104 19 SARS SARS NNP cord-350182-s10nong7 104 20 and and CC cord-350182-s10nong7 104 21 MERS MERS NNP cord-350182-s10nong7 104 22 epidemic epidemic NN cord-350182-s10nong7 104 23 Coronavirus Coronavirus NNP cord-350182-s10nong7 104 24 infections infection NNS cord-350182-s10nong7 104 25 and and CC cord-350182-s10nong7 104 26 immune immune JJ cord-350182-s10nong7 104 27 responses response NNS cord-350182-s10nong7 105 1 SARS SARS NNP cord-350182-s10nong7 105 2 - - HYPH cord-350182-s10nong7 105 3 CoV-2 CoV-2 NNP cord-350182-s10nong7 105 4 and and CC cord-350182-s10nong7 105 5 COVID-19 covid-19 VB cord-350182-s10nong7 105 6 in in IN cord-350182-s10nong7 105 7 older old JJR cord-350182-s10nong7 105 8 adults adult NNS cord-350182-s10nong7 105 9 : : : cord-350182-s10nong7 105 10 What what WP cord-350182-s10nong7 105 11 we -PRON- PRP cord-350182-s10nong7 105 12 may may MD cord-350182-s10nong7 105 13 expect expect VB cord-350182-s10nong7 105 14 regarding regard VBG cord-350182-s10nong7 105 15 pathogenesis pathogenesis NN cord-350182-s10nong7 105 16 , , , cord-350182-s10nong7 105 17 immune immune JJ cord-350182-s10nong7 105 18 responses response NNS cord-350182-s10nong7 105 19 , , , cord-350182-s10nong7 105 20 and and CC cord-350182-s10nong7 105 21 outcomes outcome NNS cord-350182-s10nong7 105 22 Definition Definition NNP cord-350182-s10nong7 105 23 , , , cord-350182-s10nong7 105 24 diagnosis diagnosis NN cord-350182-s10nong7 105 25 and and CC cord-350182-s10nong7 105 26 classification classification NN cord-350182-s10nong7 105 27 of of IN cord-350182-s10nong7 105 28 diabetes diabetes NN cord-350182-s10nong7 105 29 mellitus mellitus NN cord-350182-s10nong7 105 30 and and CC cord-350182-s10nong7 105 31 its -PRON- PRP$ cord-350182-s10nong7 105 32 complications complication NNS cord-350182-s10nong7 105 33 . . . cord-350182-s10nong7 106 1 Part part NN cord-350182-s10nong7 106 2 1 1 CD cord-350182-s10nong7 106 3 : : : cord-350182-s10nong7 107 1 Diagnosis diagnosis NN cord-350182-s10nong7 107 2 and and CC cord-350182-s10nong7 107 3 classification classification NN cord-350182-s10nong7 107 4 of of IN cord-350182-s10nong7 107 5 diabetes diabetes NN cord-350182-s10nong7 107 6 mellitus mellitus NN cord-350182-s10nong7 107 7 . . . cord-350182-s10nong7 108 1 Provisional provisional JJ cord-350182-s10nong7 108 2 report report NN cord-350182-s10nong7 108 3 of of IN cord-350182-s10nong7 108 4 a a DT cord-350182-s10nong7 108 5 WHO WHO NNP cord-350182-s10nong7 108 6 consultation consultation NN cord-350182-s10nong7 108 7 Classification classification NN cord-350182-s10nong7 108 8 and and CC cord-350182-s10nong7 108 9 diagnosis diagnosis NN cord-350182-s10nong7 108 10 of of IN cord-350182-s10nong7 108 11 diabetes diabetes NN cord-350182-s10nong7 108 12 : : : cord-350182-s10nong7 108 13 Standards standard NNS cord-350182-s10nong7 108 14 of of IN cord-350182-s10nong7 108 15 medical medical JJ cord-350182-s10nong7 108 16 care care NN cord-350182-s10nong7 108 17 in in IN cord-350182-s10nong7 108 18 diabetes-2020 diabetes-2020 NNP cord-350182-s10nong7 108 19 Type type NN cord-350182-s10nong7 108 20 1 1 CD cord-350182-s10nong7 108 21 diabetes diabetes NN cord-350182-s10nong7 108 22 Idiopathic Idiopathic NNP cord-350182-s10nong7 108 23 type type NN cord-350182-s10nong7 108 24 1 1 CD cord-350182-s10nong7 108 25 diabetes diabetes NN cord-350182-s10nong7 108 26 Pathophysiology pathophysiology NN cord-350182-s10nong7 108 27 of of IN cord-350182-s10nong7 108 28 type type NN cord-350182-s10nong7 108 29 2 2 CD cord-350182-s10nong7 108 30 diabetes diabetes NN cord-350182-s10nong7 108 31 : : : cord-350182-s10nong7 109 1 The the DT cord-350182-s10nong7 109 2 evolution evolution NN cord-350182-s10nong7 109 3 of of IN cord-350182-s10nong7 109 4 our -PRON- PRP$ cord-350182-s10nong7 109 5 understanding understanding NN cord-350182-s10nong7 109 6 on on IN cord-350182-s10nong7 109 7 behalf behalf NN cord-350182-s10nong7 109 8 of of IN cord-350182-s10nong7 109 9 the the DT cord-350182-s10nong7 109 10 IDF IDF NNP cord-350182-s10nong7 109 11 Diabetes Diabetes NNP cord-350182-s10nong7 109 12 Atlas Atlas NNP cord-350182-s10nong7 109 13 Committee Committee NNP cord-350182-s10nong7 109 14 . . . cord-350182-s10nong7 110 1 Global global JJ cord-350182-s10nong7 110 2 and and CC cord-350182-s10nong7 110 3 regional regional JJ cord-350182-s10nong7 110 4 diabetes diabetes NN cord-350182-s10nong7 110 5 prevalence prevalence NN cord-350182-s10nong7 110 6 estimates estimate NNS cord-350182-s10nong7 110 7 for for IN cord-350182-s10nong7 110 8 2019 2019 CD cord-350182-s10nong7 110 9 and and CC cord-350182-s10nong7 110 10 projections projection NNS cord-350182-s10nong7 110 11 for for IN cord-350182-s10nong7 110 12 2030 2030 CD cord-350182-s10nong7 110 13 and and CC cord-350182-s10nong7 110 14 2045 2045 CD cord-350182-s10nong7 110 15 : : : cord-350182-s10nong7 111 1 Results result NNS cord-350182-s10nong7 111 2 from from IN cord-350182-s10nong7 111 3 the the DT cord-350182-s10nong7 111 4 International International NNP cord-350182-s10nong7 111 5 Diabetes Diabetes NNP cord-350182-s10nong7 111 6 Federation Federation NNP cord-350182-s10nong7 111 7 Diabetes Diabetes NNP cord-350182-s10nong7 111 8 Atlas Atlas NNP cord-350182-s10nong7 111 9 Infections Infections NNPS cord-350182-s10nong7 111 10 in in IN cord-350182-s10nong7 111 11 patients patient NNS cord-350182-s10nong7 111 12 with with IN cord-350182-s10nong7 111 13 diabetes diabetes NN cord-350182-s10nong7 111 14 mellitus mellitus NN cord-350182-s10nong7 111 15 : : : cord-350182-s10nong7 112 1 A a DT cord-350182-s10nong7 112 2 review review NN cord-350182-s10nong7 112 3 of of IN cord-350182-s10nong7 112 4 pathogenesis pathogenesis NN cord-350182-s10nong7 112 5 Immunological immunological JJ cord-350182-s10nong7 112 6 mechanisms mechanism NNS cord-350182-s10nong7 112 7 contributing contribute VBG cord-350182-s10nong7 112 8 to to IN cord-350182-s10nong7 112 9 the the DT cord-350182-s10nong7 112 10 double double JJ cord-350182-s10nong7 112 11 burden burden NN cord-350182-s10nong7 112 12 of of IN cord-350182-s10nong7 112 13 diabetes diabetes NN cord-350182-s10nong7 112 14 and and CC cord-350182-s10nong7 112 15 intracellular intracellular JJ cord-350182-s10nong7 112 16 bacterial bacterial JJ cord-350182-s10nong7 112 17 infections infection NNS cord-350182-s10nong7 112 18 Comorbid Comorbid NNP cord-350182-s10nong7 112 19 chronic chronic JJ cord-350182-s10nong7 112 20 diseases disease NNS cord-350182-s10nong7 112 21 and and CC cord-350182-s10nong7 112 22 acute acute JJ cord-350182-s10nong7 112 23 organ organ NN cord-350182-s10nong7 112 24 injuries injury NNS cord-350182-s10nong7 112 25 are be VBP cord-350182-s10nong7 112 26 strongly strongly RB cord-350182-s10nong7 112 27 correlated correlate VBN cord-350182-s10nong7 112 28 with with IN cord-350182-s10nong7 112 29 disease disease NN cord-350182-s10nong7 112 30 severity severity NN cord-350182-s10nong7 112 31 and and CC cord-350182-s10nong7 112 32 mortality mortality NN cord-350182-s10nong7 112 33 among among IN cord-350182-s10nong7 112 34 COVID-19 covid-19 JJ cord-350182-s10nong7 112 35 patients patient NNS cord-350182-s10nong7 112 36 : : : cord-350182-s10nong7 112 37 A a DT cord-350182-s10nong7 112 38 systemic systemic JJ cord-350182-s10nong7 112 39 review review NN cord-350182-s10nong7 112 40 and and CC cord-350182-s10nong7 112 41 meta meta NNP cord-350182-s10nong7 112 42 - - HYPH cord-350182-s10nong7 112 43 analysis analysis NN cord-350182-s10nong7 112 44 Comorbid Comorbid NNP cord-350182-s10nong7 112 45 chronic chronic JJ cord-350182-s10nong7 112 46 diseases disease NNS cord-350182-s10nong7 112 47 are be VBP cord-350182-s10nong7 112 48 strongly strongly RB cord-350182-s10nong7 112 49 correlated correlate VBN cord-350182-s10nong7 112 50 with with IN cord-350182-s10nong7 112 51 disease disease NN cord-350182-s10nong7 112 52 severity severity NN cord-350182-s10nong7 112 53 among among IN cord-350182-s10nong7 112 54 COVID-19 covid-19 JJ cord-350182-s10nong7 112 55 patients patient NNS cord-350182-s10nong7 112 56 : : : cord-350182-s10nong7 112 57 A a DT cord-350182-s10nong7 112 58 systematic systematic JJ cord-350182-s10nong7 112 59 review review NN cord-350182-s10nong7 112 60 and and CC cord-350182-s10nong7 112 61 meta meta NNP cord-350182-s10nong7 112 62 - - HYPH cord-350182-s10nong7 112 63 analysis analysis NN cord-350182-s10nong7 112 64 New new JJ cord-350182-s10nong7 112 65 insights insight NNS cord-350182-s10nong7 112 66 into into IN cord-350182-s10nong7 112 67 insulin insulin NN cord-350182-s10nong7 112 68 : : : cord-350182-s10nong7 112 69 The the DT cord-350182-s10nong7 112 70 antiinflammatory antiinflammatory JJ cord-350182-s10nong7 112 71 effect effect NN cord-350182-s10nong7 112 72 and and CC cord-350182-s10nong7 112 73 its -PRON- PRP$ cord-350182-s10nong7 112 74 clinical clinical JJ cord-350182-s10nong7 112 75 relevance relevance NN cord-350182-s10nong7 112 76 de de FW cord-350182-s10nong7 112 77 Góes Góes NNP cord-350182-s10nong7 112 78 Cavalcanti Cavalcanti NNP cord-350182-s10nong7 112 79 LP LP NNP cord-350182-s10nong7 112 80 . . . cord-350182-s10nong7 113 1 Chikungunya chikungunya NN cord-350182-s10nong7 113 2 and and CC cord-350182-s10nong7 113 3 diabetes diabetes NN cord-350182-s10nong7 113 4 , , , cord-350182-s10nong7 113 5 what what WP cord-350182-s10nong7 113 6 do do VBP cord-350182-s10nong7 113 7 we -PRON- PRP cord-350182-s10nong7 113 8 know know VB cord-350182-s10nong7 113 9 ? ? . cord-350182-s10nong7 114 1 Cytokine cytokine NN cord-350182-s10nong7 114 2 and and CC cord-350182-s10nong7 114 3 cytokine cytokine NN cord-350182-s10nong7 114 4 - - HYPH cord-350182-s10nong7 114 5 like like JJ cord-350182-s10nong7 114 6 inflammation inflammation NN cord-350182-s10nong7 114 7 markers marker NNS cord-350182-s10nong7 114 8 , , , cord-350182-s10nong7 114 9 endothelial endothelial JJ cord-350182-s10nong7 114 10 dysfunction dysfunction NN cord-350182-s10nong7 114 11 , , , cord-350182-s10nong7 114 12 and and CC cord-350182-s10nong7 114 13 imbalanced imbalanced JJ cord-350182-s10nong7 114 14 coagulation coagulation NN cord-350182-s10nong7 114 15 in in IN cord-350182-s10nong7 114 16 development development NN cord-350182-s10nong7 114 17 of of IN cord-350182-s10nong7 114 18 diabetes diabetes NN cord-350182-s10nong7 114 19 and and CC cord-350182-s10nong7 114 20 its -PRON- PRP$ cord-350182-s10nong7 114 21 complications complication NNS cord-350182-s10nong7 115 1 Immune immune JJ cord-350182-s10nong7 115 2 cell cell NN cord-350182-s10nong7 115 3 - - HYPH cord-350182-s10nong7 115 4 derived derive VBN cord-350182-s10nong7 115 5 cytokines cytokine NNS cord-350182-s10nong7 115 6 contribute contribute VBP cord-350182-s10nong7 115 7 to to IN cord-350182-s10nong7 115 8 obesity obesity NN cord-350182-s10nong7 115 9 - - HYPH cord-350182-s10nong7 115 10 related relate VBN cord-350182-s10nong7 115 11 inflammation inflammation NN cord-350182-s10nong7 115 12 , , , cord-350182-s10nong7 115 13 fibrogenesis fibrogenesis NN cord-350182-s10nong7 115 14 and and CC cord-350182-s10nong7 115 15 metabolic metabolic JJ cord-350182-s10nong7 115 16 deregulation deregulation NN cord-350182-s10nong7 115 17 in in IN cord-350182-s10nong7 115 18 human human JJ cord-350182-s10nong7 115 19 adipose adipose JJ cord-350182-s10nong7 115 20 tissue tissue NN cord-350182-s10nong7 115 21 Inflammation inflammation NN cord-350182-s10nong7 115 22 and and CC cord-350182-s10nong7 115 23 insulin insulin NN cord-350182-s10nong7 115 24 resistance resistance NN cord-350182-s10nong7 115 25 Diabetes diabetes NN cord-350182-s10nong7 115 26 and and CC cord-350182-s10nong7 115 27 infection infection NN cord-350182-s10nong7 115 28 : : : cord-350182-s10nong7 116 1 Is be VBZ cord-350182-s10nong7 116 2 there there EX cord-350182-s10nong7 116 3 a a DT cord-350182-s10nong7 116 4 link link NN cord-350182-s10nong7 116 5 ? ? . cord-350182-s10nong7 117 1 -A -A : cord-350182-s10nong7 117 2 mini mini JJ cord-350182-s10nong7 117 3 - - JJ cord-350182-s10nong7 117 4 review review NN cord-350182-s10nong7 117 5 Immune immune JJ cord-350182-s10nong7 117 6 dysfunction dysfunction NN cord-350182-s10nong7 117 7 in in IN cord-350182-s10nong7 117 8 patients patient NNS cord-350182-s10nong7 117 9 with with IN cord-350182-s10nong7 117 10 diabetes diabetes NN cord-350182-s10nong7 117 11 mellitus mellitus NN cord-350182-s10nong7 117 12 ( ( -LRB- cord-350182-s10nong7 117 13 DM dm NN cord-350182-s10nong7 117 14 ) ) -RRB- cord-350182-s10nong7 118 1 Lymphopenia Lymphopenia NNP cord-350182-s10nong7 118 2 predicts predict VBZ cord-350182-s10nong7 118 3 disease disease NN cord-350182-s10nong7 118 4 severity severity NN cord-350182-s10nong7 118 5 of of IN cord-350182-s10nong7 118 6 COVID-19 COVID-19 NNP cord-350182-s10nong7 118 7 : : : cord-350182-s10nong7 118 8 A a DT cord-350182-s10nong7 118 9 descriptive descriptive JJ cord-350182-s10nong7 118 10 and and CC cord-350182-s10nong7 118 11 predictive predictive JJ cord-350182-s10nong7 118 12 study study NN cord-350182-s10nong7 119 1 Common common JJ cord-350182-s10nong7 119 2 infections infection NNS cord-350182-s10nong7 119 3 in in IN cord-350182-s10nong7 119 4 diabetes diabetes NN cord-350182-s10nong7 119 5 : : : cord-350182-s10nong7 120 1 Pathogenesis pathogenesis NN cord-350182-s10nong7 120 2 , , , cord-350182-s10nong7 120 3 management management NN cord-350182-s10nong7 120 4 and and CC cord-350182-s10nong7 120 5 relationship relationship NN cord-350182-s10nong7 120 6 to to IN cord-350182-s10nong7 120 7 glycaemic glycaemic JJ cord-350182-s10nong7 120 8 control control NNP cord-350182-s10nong7 120 9 COVID-19 COVID-19 NNP cord-350182-s10nong7 120 10 and and CC cord-350182-s10nong7 120 11 diabetes diabete VBZ cord-350182-s10nong7 120 12 : : : cord-350182-s10nong7 120 13 Knowledge knowledge NN cord-350182-s10nong7 120 14 in in IN cord-350182-s10nong7 120 15 progress progress NN cord-350182-s10nong7 120 16 Is be VBZ cord-350182-s10nong7 120 17 COVID-19 covid-19 VB cord-350182-s10nong7 120 18 an an DT cord-350182-s10nong7 120 19 endothelial endothelial JJ cord-350182-s10nong7 120 20 disease disease NN cord-350182-s10nong7 120 21 ? ? . cord-350182-s10nong7 121 1 Clinical clinical JJ cord-350182-s10nong7 121 2 and and CC cord-350182-s10nong7 121 3 basic basic JJ cord-350182-s10nong7 121 4 evidence evidence NN cord-350182-s10nong7 121 5 Risk risk NN cord-350182-s10nong7 121 6 factors factor NNS cord-350182-s10nong7 121 7 of of IN cord-350182-s10nong7 121 8 critical critical JJ cord-350182-s10nong7 121 9 & & CC cord-350182-s10nong7 121 10 mortal mortal JJ cord-350182-s10nong7 121 11 COVID-19 COVID-19 NNP cord-350182-s10nong7 121 12 cases case NNS cord-350182-s10nong7 121 13 : : : cord-350182-s10nong7 121 14 A a DT cord-350182-s10nong7 121 15 systematic systematic JJ cord-350182-s10nong7 121 16 literature literature NN cord-350182-s10nong7 121 17 review review NN cord-350182-s10nong7 121 18 and and CC cord-350182-s10nong7 121 19 meta meta NNP cord-350182-s10nong7 121 20 - - HYPH cord-350182-s10nong7 121 21 analysis analysis NN cord-350182-s10nong7 121 22 Are be VBP cord-350182-s10nong7 121 23 patients patient NNS cord-350182-s10nong7 121 24 with with IN cord-350182-s10nong7 121 25 hypertension hypertension NN cord-350182-s10nong7 121 26 and and CC cord-350182-s10nong7 121 27 diabetes diabetes NN cord-350182-s10nong7 121 28 mellitus mellitus NN cord-350182-s10nong7 121 29 at at IN cord-350182-s10nong7 121 30 increased increase VBN cord-350182-s10nong7 121 31 risk risk NN cord-350182-s10nong7 121 32 for for IN cord-350182-s10nong7 121 33 COVID-19 covid-19 JJ cord-350182-s10nong7 121 34 infection infection NN cord-350182-s10nong7 121 35 ? ? . cord-350182-s10nong7 122 1 Commentary commentary NN cord-350182-s10nong7 122 2 . . . cord-350182-s10nong7 123 1 COVID-19 covid-19 VB cord-350182-s10nong7 123 2 and and CC cord-350182-s10nong7 123 3 diabetes diabete VBZ cord-350182-s10nong7 123 4 mellitus mellitus NN cord-350182-s10nong7 123 5 : : : cord-350182-s10nong7 124 1 What what WP cord-350182-s10nong7 124 2 we -PRON- PRP cord-350182-s10nong7 124 3 know know VBP cord-350182-s10nong7 124 4 , , , cord-350182-s10nong7 124 5 how how WRB cord-350182-s10nong7 124 6 our -PRON- PRP$ cord-350182-s10nong7 124 7 patients patient NNS cord-350182-s10nong7 124 8 should should MD cord-350182-s10nong7 124 9 be be VB cord-350182-s10nong7 124 10 treated treat VBN cord-350182-s10nong7 124 11 now now RB cord-350182-s10nong7 124 12 , , , cord-350182-s10nong7 124 13 and and CC cord-350182-s10nong7 124 14 what what WP cord-350182-s10nong7 124 15 should should MD cord-350182-s10nong7 124 16 happen happen VB cord-350182-s10nong7 124 17 next next RB cord-350182-s10nong7 124 18 COVID-19 COVID-19 NNP cord-350182-s10nong7 124 19 in in IN cord-350182-s10nong7 124 20 diabetic diabetic JJ cord-350182-s10nong7 124 21 patients patient NNS cord-350182-s10nong7 124 22 : : : cord-350182-s10nong7 124 23 Related related JJ cord-350182-s10nong7 124 24 risks risk NNS cord-350182-s10nong7 124 25 and and CC cord-350182-s10nong7 124 26 specifics specific NNS cord-350182-s10nong7 124 27 of of IN cord-350182-s10nong7 124 28 management management NN cord-350182-s10nong7 124 29 Prevention Prevention NNP cord-350182-s10nong7 124 30 and and CC cord-350182-s10nong7 124 31 management management NN cord-350182-s10nong7 124 32 of of IN cord-350182-s10nong7 124 33 COVID-19 COVID-19 NNP cord-350182-s10nong7 124 34 among among IN cord-350182-s10nong7 124 35 patients patient NNS cord-350182-s10nong7 124 36 with with IN cord-350182-s10nong7 124 37 diabetes diabetes NN cord-350182-s10nong7 124 38 : : : cord-350182-s10nong7 124 39 An an DT cord-350182-s10nong7 124 40 appraisal appraisal NN cord-350182-s10nong7 124 41 of of IN cord-350182-s10nong7 124 42 the the DT cord-350182-s10nong7 124 43 literature literature NN cord-350182-s10nong7 125 1 Publisher publisher NN cord-350182-s10nong7 125 2 's 's POS cord-350182-s10nong7 125 3 Note Note NNP cord-350182-s10nong7 125 4 Springer Springer NNP cord-350182-s10nong7 125 5 Nature Nature NNP cord-350182-s10nong7 125 6 remains remain VBZ cord-350182-s10nong7 125 7 neutral neutral JJ cord-350182-s10nong7 125 8 with with IN cord-350182-s10nong7 125 9 regard regard NN cord-350182-s10nong7 125 10 to to IN cord-350182-s10nong7 125 11 jurisdictional jurisdictional JJ cord-350182-s10nong7 125 12 claims claim NNS cord-350182-s10nong7 125 13 in in IN cord-350182-s10nong7 125 14 published publish VBN cord-350182-s10nong7 125 15 maps map NNS cord-350182-s10nong7 125 16 and and CC cord-350182-s10nong7 125 17 institutional institutional JJ cord-350182-s10nong7 125 18 affiliations affiliation NNS cord-350182-s10nong7 125 19 Conflict conflict NN cord-350182-s10nong7 125 20 of of IN cord-350182-s10nong7 125 21 interest interest NN cord-350182-s10nong7 126 1 The the DT cord-350182-s10nong7 126 2 authors author NNS cord-350182-s10nong7 126 3 declare declare VBP cord-350182-s10nong7 126 4 that that IN cord-350182-s10nong7 126 5 they -PRON- PRP cord-350182-s10nong7 126 6 have have VBP cord-350182-s10nong7 126 7 no no DT cord-350182-s10nong7 126 8 conflict conflict NN cord-350182-s10nong7 126 9 of of IN cord-350182-s10nong7 126 10 interest interest NN cord-350182-s10nong7 126 11 . . .