id sid tid token lemma pos cord-104204-pdnkabwj 1 1 key key JJ cord-104204-pdnkabwj 1 2 : : : cord-104204-pdnkabwj 1 3 cord-104204-pdnkabwj cord-104204-pdnkabwj ADD cord-104204-pdnkabwj 2 1 authors author NNS cord-104204-pdnkabwj 2 2 : : : cord-104204-pdnkabwj 2 3 Tatu Tatu NNP cord-104204-pdnkabwj 2 4 , , , cord-104204-pdnkabwj 2 5 C C NNP cord-104204-pdnkabwj 2 6 A A NNP cord-104204-pdnkabwj 2 7 ; ; : cord-104204-pdnkabwj 2 8 Orem Orem NNP cord-104204-pdnkabwj 2 9 , , , cord-104204-pdnkabwj 2 10 W W NNP cord-104204-pdnkabwj 2 11 H H NNP cord-104204-pdnkabwj 2 12 ; ; : cord-104204-pdnkabwj 2 13 Finkelman Finkelman NNP cord-104204-pdnkabwj 2 14 , , , cord-104204-pdnkabwj 2 15 R r NN cord-104204-pdnkabwj 2 16 B b NN cord-104204-pdnkabwj 2 17 ; ; : cord-104204-pdnkabwj 2 18 Feder Feder NNP cord-104204-pdnkabwj 2 19 , , , cord-104204-pdnkabwj 2 20 G G NNP cord-104204-pdnkabwj 2 21 L l NN cord-104204-pdnkabwj 2 22 title title NN cord-104204-pdnkabwj 2 23 : : : cord-104204-pdnkabwj 2 24 The the DT cord-104204-pdnkabwj 2 25 etiology etiology NN cord-104204-pdnkabwj 2 26 of of IN cord-104204-pdnkabwj 2 27 Balkan balkan JJ cord-104204-pdnkabwj 2 28 endemic endemic JJ cord-104204-pdnkabwj 2 29 nephropathy nephropathy NN cord-104204-pdnkabwj 2 30 : : : cord-104204-pdnkabwj 2 31 still still RB cord-104204-pdnkabwj 2 32 more more JJR cord-104204-pdnkabwj 2 33 questions question NNS cord-104204-pdnkabwj 2 34 than than IN cord-104204-pdnkabwj 2 35 answers answer NNS cord-104204-pdnkabwj 2 36 . . . cord-104204-pdnkabwj 3 1 date date NN cord-104204-pdnkabwj 3 2 : : : cord-104204-pdnkabwj 3 3 1998 1998 CD cord-104204-pdnkabwj 3 4 - - SYM cord-104204-pdnkabwj 3 5 11 11 CD cord-104204-pdnkabwj 3 6 - - SYM cord-104204-pdnkabwj 3 7 17 17 CD cord-104204-pdnkabwj 3 8 journal journal NN cord-104204-pdnkabwj 3 9 : : : cord-104204-pdnkabwj 4 1 Environ Environ NNP cord-104204-pdnkabwj 4 2 Health Health NNP cord-104204-pdnkabwj 4 3 Perspect Perspect NNP cord-104204-pdnkabwj 4 4 DOI DOI NNP cord-104204-pdnkabwj 4 5 : : : cord-104204-pdnkabwj 5 1 nan nan NNP cord-104204-pdnkabwj 5 2 sha sha NNP cord-104204-pdnkabwj 5 3 : : : cord-104204-pdnkabwj 6 1 a545e4e85d52c1aa0eaea99a9c1ce04fbbcd38eb a545e4e85d52c1aa0eaea99a9c1ce04fbbcd38eb NFP cord-104204-pdnkabwj 6 2 doc_id doc_id CD cord-104204-pdnkabwj 6 3 : : : cord-104204-pdnkabwj 6 4 104204 104204 CD cord-104204-pdnkabwj 6 5 cord_uid cord_uid NNS cord-104204-pdnkabwj 6 6 : : : cord-104204-pdnkabwj 7 1 pdnkabwj pdnkabwj NNP cord-104204-pdnkabwj 7 2 Balkan Balkan NNP cord-104204-pdnkabwj 7 3 endemic endemic JJ cord-104204-pdnkabwj 7 4 nephropathy nephropathy NN cord-104204-pdnkabwj 7 5 ( ( -LRB- cord-104204-pdnkabwj 7 6 BEN BEN NNP cord-104204-pdnkabwj 7 7 ) ) -RRB- cord-104204-pdnkabwj 7 8 has have VBZ cord-104204-pdnkabwj 7 9 attracted attract VBN cord-104204-pdnkabwj 7 10 increasing increase VBG cord-104204-pdnkabwj 7 11 attention attention NN cord-104204-pdnkabwj 7 12 as as IN cord-104204-pdnkabwj 7 13 a a DT cord-104204-pdnkabwj 7 14 possible possible JJ cord-104204-pdnkabwj 7 15 environmental environmental JJ cord-104204-pdnkabwj 7 16 disease disease NN cord-104204-pdnkabwj 7 17 , , , cord-104204-pdnkabwj 7 18 and and CC cord-104204-pdnkabwj 7 19 a a DT cord-104204-pdnkabwj 7 20 significant significant JJ cord-104204-pdnkabwj 7 21 amount amount NN cord-104204-pdnkabwj 7 22 of of IN cord-104204-pdnkabwj 7 23 research research NN cord-104204-pdnkabwj 7 24 from from IN cord-104204-pdnkabwj 7 25 complementary complementary JJ cord-104204-pdnkabwj 7 26 scientific scientific JJ cord-104204-pdnkabwj 7 27 fields field NNS cord-104204-pdnkabwj 7 28 has have VBZ cord-104204-pdnkabwj 7 29 been be VBN cord-104204-pdnkabwj 7 30 dedicated dedicate VBN cord-104204-pdnkabwj 7 31 to to IN cord-104204-pdnkabwj 7 32 its -PRON- PRP$ cord-104204-pdnkabwj 7 33 etiology etiology NN cord-104204-pdnkabwj 7 34 . . . cord-104204-pdnkabwj 8 1 There there EX cord-104204-pdnkabwj 8 2 are be VBP cord-104204-pdnkabwj 8 3 two two CD cord-104204-pdnkabwj 8 4 actual actual JJ cord-104204-pdnkabwj 8 5 competing compete VBG cord-104204-pdnkabwj 8 6 theories theory NNS cord-104204-pdnkabwj 8 7 attempting attempt VBG cord-104204-pdnkabwj 8 8 to to TO cord-104204-pdnkabwj 8 9 explain explain VB cord-104204-pdnkabwj 8 10 the the DT cord-104204-pdnkabwj 8 11 cause cause NN cord-104204-pdnkabwj 8 12 of of IN cord-104204-pdnkabwj 8 13 this this DT cord-104204-pdnkabwj 8 14 kidney kidney NN cord-104204-pdnkabwj 8 15 disease disease NN cord-104204-pdnkabwj 8 16 : : : cord-104204-pdnkabwj 8 17 1 1 LS cord-104204-pdnkabwj 8 18 ) ) -RRB- cord-104204-pdnkabwj 8 19 the the DT cord-104204-pdnkabwj 8 20 mycotoxin mycotoxin NN cord-104204-pdnkabwj 8 21 hypothesis hypothesis NN cord-104204-pdnkabwj 8 22 , , , cord-104204-pdnkabwj 8 23 which which WDT cord-104204-pdnkabwj 8 24 considers consider VBZ cord-104204-pdnkabwj 8 25 that that IN cord-104204-pdnkabwj 8 26 BEN BEN NNP cord-104204-pdnkabwj 8 27 is be VBZ cord-104204-pdnkabwj 8 28 produced produce VBN cord-104204-pdnkabwj 8 29 by by IN cord-104204-pdnkabwj 8 30 ochratoxin ochratoxin NNP cord-104204-pdnkabwj 8 31 A A NNP cord-104204-pdnkabwj 8 32 ingested ingest VBN cord-104204-pdnkabwj 8 33 intermittently intermittently RB cord-104204-pdnkabwj 8 34 in in IN cord-104204-pdnkabwj 8 35 small small JJ cord-104204-pdnkabwj 8 36 amounts amount NNS cord-104204-pdnkabwj 8 37 by by IN cord-104204-pdnkabwj 8 38 the the DT cord-104204-pdnkabwj 8 39 individuals individual NNS cord-104204-pdnkabwj 8 40 in in IN cord-104204-pdnkabwj 8 41 the the DT cord-104204-pdnkabwj 8 42 endemic endemic JJ cord-104204-pdnkabwj 8 43 regions region NNS cord-104204-pdnkabwj 8 44 , , , cord-104204-pdnkabwj 8 45 and and CC cord-104204-pdnkabwj 8 46 2 2 LS cord-104204-pdnkabwj 8 47 ) ) -RRB- cord-104204-pdnkabwj 8 48 the the DT cord-104204-pdnkabwj 8 49 Pliocene Pliocene NNP cord-104204-pdnkabwj 8 50 lignite lignite NN cord-104204-pdnkabwj 8 51 hypothesis hypothesis NN cord-104204-pdnkabwj 8 52 , , , cord-104204-pdnkabwj 8 53 which which WDT cord-104204-pdnkabwj 8 54 proposes propose VBZ cord-104204-pdnkabwj 8 55 that that IN cord-104204-pdnkabwj 8 56 the the DT cord-104204-pdnkabwj 8 57 disease disease NN cord-104204-pdnkabwj 8 58 is be VBZ cord-104204-pdnkabwj 8 59 caused cause VBN cord-104204-pdnkabwj 8 60 by by IN cord-104204-pdnkabwj 8 61 long long JJ cord-104204-pdnkabwj 8 62 - - HYPH cord-104204-pdnkabwj 8 63 term term NN cord-104204-pdnkabwj 8 64 exposure exposure NN cord-104204-pdnkabwj 8 65 to to IN cord-104204-pdnkabwj 8 66 polycyclic polycyclic JJ cord-104204-pdnkabwj 8 67 aromatic aromatic JJ cord-104204-pdnkabwj 8 68 hydrocarbons hydrocarbon NNS cord-104204-pdnkabwj 8 69 and and CC cord-104204-pdnkabwj 8 70 other other JJ cord-104204-pdnkabwj 8 71 toxic toxic JJ cord-104204-pdnkabwj 8 72 organic organic JJ cord-104204-pdnkabwj 8 73 compounds compound NNS cord-104204-pdnkabwj 8 74 leaching leach VBG cord-104204-pdnkabwj 8 75 into into IN cord-104204-pdnkabwj 8 76 the the DT cord-104204-pdnkabwj 8 77 well well NN cord-104204-pdnkabwj 8 78 drinking drinking NN cord-104204-pdnkabwj 8 79 water water NN cord-104204-pdnkabwj 8 80 from from IN cord-104204-pdnkabwj 8 81 low low JJ cord-104204-pdnkabwj 8 82 rank rank NN cord-104204-pdnkabwj 8 83 coals coal NNS cord-104204-pdnkabwj 8 84 underlying underlie VBG cord-104204-pdnkabwj 8 85 or or CC cord-104204-pdnkabwj 8 86 proximal proximal JJ cord-104204-pdnkabwj 8 87 to to IN cord-104204-pdnkabwj 8 88 the the DT cord-104204-pdnkabwj 8 89 endemic endemic JJ cord-104204-pdnkabwj 8 90 settlements settlement NNS cord-104204-pdnkabwj 8 91 . . . cord-104204-pdnkabwj 9 1 We -PRON- PRP cord-104204-pdnkabwj 9 2 outline outline VBP cord-104204-pdnkabwj 9 3 the the DT cord-104204-pdnkabwj 9 4 current current JJ cord-104204-pdnkabwj 9 5 developments development NNS cord-104204-pdnkabwj 9 6 and and CC cord-104204-pdnkabwj 9 7 future future JJ cord-104204-pdnkabwj 9 8 prospects prospect NNS cord-104204-pdnkabwj 9 9 in in IN cord-104204-pdnkabwj 9 10 the the DT cord-104204-pdnkabwj 9 11 study study NN cord-104204-pdnkabwj 9 12 of of IN cord-104204-pdnkabwj 9 13 BEN BEN NNP cord-104204-pdnkabwj 9 14 and and CC cord-104204-pdnkabwj 9 15 differentiate differentiate VB cord-104204-pdnkabwj 9 16 possible possible JJ cord-104204-pdnkabwj 9 17 factors factor NNS cord-104204-pdnkabwj 9 18 and and CC cord-104204-pdnkabwj 9 19 cofactors cofactor NNS cord-104204-pdnkabwj 9 20 in in IN cord-104204-pdnkabwj 9 21 disease disease NN cord-104204-pdnkabwj 9 22 etiology etiology NN cord-104204-pdnkabwj 9 23 . . . cord-104204-pdnkabwj 10 1 Balkan balkan JJ cord-104204-pdnkabwj 10 2 endemic endemic JJ cord-104204-pdnkabwj 10 3 nephropathy nephropathy NN cord-104204-pdnkabwj 10 4 ( ( -LRB- cord-104204-pdnkabwj 10 5 BEN BEN NNP cord-104204-pdnkabwj 10 6 ) ) -RRB- cord-104204-pdnkabwj 10 7 has have VBZ cord-104204-pdnkabwj 10 8 attracted attract VBN cord-104204-pdnkabwj 10 9 increasing increase VBG cord-104204-pdnkabwj 10 10 attention attention NN cord-104204-pdnkabwj 10 11 as as IN cord-104204-pdnkabwj 10 12 a a DT cord-104204-pdnkabwj 10 13 possible possible JJ cord-104204-pdnkabwj 10 14 environmental environmental JJ cord-104204-pdnkabwj 10 15 disease disease NN cord-104204-pdnkabwj 10 16 , , , cord-104204-pdnkabwj 10 17 and and CC cord-104204-pdnkabwj 10 18 a a DT cord-104204-pdnkabwj 10 19 significant significant JJ cord-104204-pdnkabwj 10 20 mount mount NN cord-104204-pdnkabwj 10 21 of of IN cord-104204-pdnkabwj 10 22 research research NN cord-104204-pdnkabwj 10 23 from from IN cord-104204-pdnkabwj 10 24 complementary complementary JJ cord-104204-pdnkabwj 10 25 scientific scientific JJ cord-104204-pdnkabwj 10 26 fields field NNS cord-104204-pdnkabwj 10 27 has have VBZ cord-104204-pdnkabwj 10 28 been be VBN cord-104204-pdnkabwj 10 29 dedicated dedicate VBN cord-104204-pdnkabwj 10 30 to to IN cord-104204-pdnkabwj 10 31 its -PRON- PRP$ cord-104204-pdnkabwj 10 32 etiology etiology NN cord-104204-pdnkabwj 10 33 . . . cord-104204-pdnkabwj 11 1 There there EX cord-104204-pdnkabwj 11 2 are be VBP cord-104204-pdnkabwj 11 3 two two CD cord-104204-pdnkabwj 11 4 actual actual JJ cord-104204-pdnkabwj 11 5 competing compete VBG cord-104204-pdnkabwj 11 6 theories theory NNS cord-104204-pdnkabwj 11 7 attempting attempt VBG cord-104204-pdnkabwj 11 8 to to TO cord-104204-pdnkabwj 11 9 explain explain VB cord-104204-pdnkabwj 11 10 the the DT cord-104204-pdnkabwj 11 11 cause cause NN cord-104204-pdnkabwj 11 12 of of IN cord-104204-pdnkabwj 11 13 this this DT cord-104204-pdnkabwj 11 14 kidney kidney NN cord-104204-pdnkabwj 11 15 disease disease NN cord-104204-pdnkabwj 11 16 : : : cord-104204-pdnkabwj 11 17 1 1 LS cord-104204-pdnkabwj 11 18 ) ) -RRB- cord-104204-pdnkabwj 11 19 the the DT cord-104204-pdnkabwj 11 20 mycotoxin mycotoxin NN cord-104204-pdnkabwj 11 21 hypothesis hypothesis NN cord-104204-pdnkabwj 11 22 , , , cord-104204-pdnkabwj 11 23 which which WDT cord-104204-pdnkabwj 11 24 considers consider VBZ cord-104204-pdnkabwj 11 25 that that IN cord-104204-pdnkabwj 11 26 BEN BEN NNP cord-104204-pdnkabwj 11 27 is be VBZ cord-104204-pdnkabwj 11 28 produced produce VBN cord-104204-pdnkabwj 11 29 by by IN cord-104204-pdnkabwj 11 30 ochratoxin ochratoxin NNP cord-104204-pdnkabwj 11 31 A A NNP cord-104204-pdnkabwj 11 32 ingested ingest VBN cord-104204-pdnkabwj 11 33 intermittently intermittently RB cord-104204-pdnkabwj 11 34 in in IN cord-104204-pdnkabwj 11 35 small small JJ cord-104204-pdnkabwj 11 36 amounts amount NNS cord-104204-pdnkabwj 11 37 by by IN cord-104204-pdnkabwj 11 38 the the DT cord-104204-pdnkabwj 11 39 indivriduals indivridual NNS cord-104204-pdnkabwj 11 40 in in IN cord-104204-pdnkabwj 11 41 the the DT cord-104204-pdnkabwj 11 42 endemic endemic JJ cord-104204-pdnkabwj 11 43 regions region NNS cord-104204-pdnkabwj 11 44 , , , cord-104204-pdnkabwj 11 45 and and CC cord-104204-pdnkabwj 11 46 2 2 LS cord-104204-pdnkabwj 11 47 ) ) -RRB- cord-104204-pdnkabwj 11 48 the the DT cord-104204-pdnkabwj 11 49 Pliocene Pliocene NNP cord-104204-pdnkabwj 11 50 lignite lignite NN cord-104204-pdnkabwj 11 51 hypothesis hypothesis NN cord-104204-pdnkabwj 11 52 , , , cord-104204-pdnkabwj 11 53 which which WDT cord-104204-pdnkabwj 11 54 proposes propose VBZ cord-104204-pdnkabwj 11 55 that that IN cord-104204-pdnkabwj 11 56 the the DT cord-104204-pdnkabwj 11 57 disease disease NN cord-104204-pdnkabwj 11 58 is be VBZ cord-104204-pdnkabwj 11 59 caused cause VBN cord-104204-pdnkabwj 11 60 by by IN cord-104204-pdnkabwj 11 61 long long JJ cord-104204-pdnkabwj 11 62 - - HYPH cord-104204-pdnkabwj 11 63 term term NN cord-104204-pdnkabwj 11 64 exposure exposure NN cord-104204-pdnkabwj 11 65 to to IN cord-104204-pdnkabwj 11 66 polycyclic polycyclic JJ cord-104204-pdnkabwj 11 67 aromatic aromatic JJ cord-104204-pdnkabwj 11 68 hydrocarbons hydrocarbon NNS cord-104204-pdnkabwj 11 69 and and CC cord-104204-pdnkabwj 11 70 other other JJ cord-104204-pdnkabwj 11 71 toxic toxic JJ cord-104204-pdnkabwj 11 72 organic organic JJ cord-104204-pdnkabwj 11 73 compounds compound NNS cord-104204-pdnkabwj 11 74 leaching leach VBG cord-104204-pdnkabwj 11 75 into into IN cord-104204-pdnkabwj 11 76 the the DT cord-104204-pdnkabwj 11 77 well well NN cord-104204-pdnkabwj 11 78 drinking drinking NN cord-104204-pdnkabwj 11 79 water water NN cord-104204-pdnkabwj 11 80 from from IN cord-104204-pdnkabwj 11 81 low low JJ cord-104204-pdnkabwj 11 82 rank rank NN cord-104204-pdnkabwj 11 83 coals coal NNS cord-104204-pdnkabwj 11 84 underlying underlie VBG cord-104204-pdnkabwj 11 85 or or CC cord-104204-pdnkabwj 11 86 proximal proximal JJ cord-104204-pdnkabwj 11 87 to to IN cord-104204-pdnkabwj 11 88 the the DT cord-104204-pdnkabwj 11 89 enidemic enidemic JJ cord-104204-pdnkabwj 11 90 settdements settdement NNS cord-104204-pdnkabwj 11 91 . . . cord-104204-pdnkabwj 12 1 We -PRON- PRP cord-104204-pdnkabwj 12 2 outline outline VBP cord-104204-pdnkabwj 12 3 the the DT cord-104204-pdnkabwj 12 4 current current JJ cord-104204-pdnkabwj 12 5 developments development NNS cord-104204-pdnkabwj 12 6 and and CC cord-104204-pdnkabwj 12 7 future future JJ cord-104204-pdnkabwj 12 8 prospects prospect NNS cord-104204-pdnkabwj 12 9 in in IN cord-104204-pdnkabwj 12 10 the the DT cord-104204-pdnkabwj 12 11 study study NN cord-104204-pdnkabwj 12 12 of of IN cord-104204-pdnkabwj 12 13 BEN BEN NNP cord-104204-pdnkabwj 12 14 and and CC cord-104204-pdnkabwj 12 15 differentiate differentiate VB cord-104204-pdnkabwj 12 16 possible possible JJ cord-104204-pdnkabwj 12 17 factors factor NNS cord-104204-pdnkabwj 12 18 and and CC cord-104204-pdnkabwj 12 19 cofactors cofactor NNS cord-104204-pdnkabwj 12 20 in in IN cord-104204-pdnkabwj 12 21 disease disease NN cord-104204-pdnkabwj 12 22 etiology etiology NN cord-104204-pdnkabwj 12 23 . . . cord-104204-pdnkabwj 13 1 Key key JJ cord-104204-pdnkabwj 13 2 workr workr NNS cord-104204-pdnkabwj 13 3 . . . cord-104204-pdnkabwj 14 1 aromatic aromatic JJ cord-104204-pdnkabwj 14 2 compounds compound NNS cord-104204-pdnkabwj 14 3 , , , cord-104204-pdnkabwj 14 4 Balkan balkan JJ cord-104204-pdnkabwj 14 5 endemic endemic JJ cord-104204-pdnkabwj 14 6 nephropathy nephropathy NN cord-104204-pdnkabwj 14 7 , , , cord-104204-pdnkabwj 14 8 chronic chronic JJ cord-104204-pdnkabwj 14 9 interstitial interstitial JJ cord-104204-pdnkabwj 14 10 nephropathy nephropathy NN cord-104204-pdnkabwj 14 11 , , , cord-104204-pdnkabwj 14 12 environmental environmental JJ cord-104204-pdnkabwj 14 13 disease disease NN cord-104204-pdnkabwj 14 14 , , , cord-104204-pdnkabwj 14 15 ochatoxin ochatoxin JJ cord-104204-pdnkabwj 14 16 , , , cord-104204-pdnkabwj 14 17 Pliocene Pliocene NNP cord-104204-pdnkabwj 14 18 lignite lignite NN cord-104204-pdnkabwj 14 19 , , , cord-104204-pdnkabwj 14 20 urinary urinary JJ cord-104204-pdnkabwj 14 21 tract tract JJ cord-104204-pdnkabwj 14 22 tumors tumor NNS cord-104204-pdnkabwj 14 23 . . . cord-104204-pdnkabwj 15 1 Environ Environ NNP cord-104204-pdnkabwj 15 2 Health Health NNP cord-104204-pdnkabwj 15 3 Perspect Perspect NNP cord-104204-pdnkabwj 15 4 106:689 106:689 CD cord-104204-pdnkabwj 15 5 - - HYPH cord-104204-pdnkabwj 15 6 700 700 CD cord-104204-pdnkabwj 15 7 ( ( -LRB- cord-104204-pdnkabwj 15 8 1998 1998 CD cord-104204-pdnkabwj 15 9 ) ) -RRB- cord-104204-pdnkabwj 15 10 . . . cord-104204-pdnkabwj 16 1 [ [ -LRB- cord-104204-pdnkabwj 16 2 Online Online NNP cord-104204-pdnkabwj 16 3 9 9 CD cord-104204-pdnkabwj 16 4 October October NNP cord-104204-pdnkabwj 16 5 19981 19981 CD cord-104204-pdnkabwj 17 1 htp:/ellehpnetl.niehs.nih.gov htp:/ellehpnetl.niehs.nih.gov NNP cord-104204-pdnkabwj 17 2 / / SYM cord-104204-pdnkabwj 17 3 docs/1998/1106p689 docs/1998/1106p689 NNP cord-104204-pdnkabwj 17 4 - - HYPH cord-104204-pdnkabwj 17 5 700tat1abstract.html 700tat1abstract.html CD cord-104204-pdnkabwj 18 1 A a DT cord-104204-pdnkabwj 18 2 matter matter NN cord-104204-pdnkabwj 18 3 of of IN cord-104204-pdnkabwj 18 4 debate debate NN cord-104204-pdnkabwj 18 5 for for IN cord-104204-pdnkabwj 18 6 more more JJR cord-104204-pdnkabwj 18 7 than than IN cord-104204-pdnkabwj 18 8 four four CD cord-104204-pdnkabwj 18 9 decades decade NNS cord-104204-pdnkabwj 18 10 ( ( -LRB- cord-104204-pdnkabwj 18 11 1 1 CD cord-104204-pdnkabwj 18 12 ) ) -RRB- cord-104204-pdnkabwj 18 13 , , , cord-104204-pdnkabwj 18 14 Balkan balkan JJ cord-104204-pdnkabwj 18 15 endemic endemic JJ cord-104204-pdnkabwj 18 16 nephropathy nephropathy NN cord-104204-pdnkabwj 18 17 ( ( -LRB- cord-104204-pdnkabwj 18 18 BEN BEN NNP cord-104204-pdnkabwj 18 19 ) ) -RRB- cord-104204-pdnkabwj 18 20 is be VBZ cord-104204-pdnkabwj 18 21 a a DT cord-104204-pdnkabwj 18 22 chronic chronic JJ cord-104204-pdnkabwj 18 23 tubulointerstitial tubulointerstitial JJ cord-104204-pdnkabwj 18 24 nephropathy nephropathy NN cord-104204-pdnkabwj 18 25 ( ( -LRB- cord-104204-pdnkabwj 18 26 CIN CIN NNP cord-104204-pdnkabwj 18 27 ) ) -RRB- cord-104204-pdnkabwj 18 28 described describe VBD cord-104204-pdnkabwj 18 29 so so RB cord-104204-pdnkabwj 18 30 far far RB cord-104204-pdnkabwj 18 31 in in IN cord-104204-pdnkabwj 18 32 several several JJ cord-104204-pdnkabwj 18 33 rural rural JJ cord-104204-pdnkabwj 18 34 regions region NNS cord-104204-pdnkabwj 18 35 of of IN cord-104204-pdnkabwj 18 36 Bulgaria Bulgaria NNP cord-104204-pdnkabwj 18 37 , , , cord-104204-pdnkabwj 18 38 Romania Romania NNP cord-104204-pdnkabwj 18 39 , , , cord-104204-pdnkabwj 18 40 and and CC cord-104204-pdnkabwj 18 41 the the DT cord-104204-pdnkabwj 18 42 former former JJ cord-104204-pdnkabwj 18 43 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 18 44 ( ( -LRB- cord-104204-pdnkabwj 18 45 Serbia Serbia NNP cord-104204-pdnkabwj 18 46 , , , cord-104204-pdnkabwj 18 47 Croatia Croatia NNP cord-104204-pdnkabwj 18 48 , , , cord-104204-pdnkabwj 18 49 and and CC cord-104204-pdnkabwj 18 50 Bosnia Bosnia NNP cord-104204-pdnkabwj 18 51 ) ) -RRB- cord-104204-pdnkabwj 18 52 . . . cord-104204-pdnkabwj 19 1 Most Most JJS cord-104204-pdnkabwj 19 2 of of IN cord-104204-pdnkabwj 19 3 the the DT cord-104204-pdnkabwj 19 4 endemic endemic JJ cord-104204-pdnkabwj 19 5 villages village NNS cord-104204-pdnkabwj 19 6 are be VBP cord-104204-pdnkabwj 19 7 located locate VBN cord-104204-pdnkabwj 19 8 on on IN cord-104204-pdnkabwj 19 9 alluvial alluvial JJ cord-104204-pdnkabwj 19 10 valleys valley NNS cord-104204-pdnkabwj 19 11 of of IN cord-104204-pdnkabwj 19 12 streams stream NNS cord-104204-pdnkabwj 19 13 that that WDT cord-104204-pdnkabwj 19 14 are be VBP cord-104204-pdnkabwj 19 15 tributaries tributary NNS cord-104204-pdnkabwj 19 16 of of IN cord-104204-pdnkabwj 19 17 the the DT cord-104204-pdnkabwj 19 18 Danube Danube NNP cord-104204-pdnkabwj 19 19 River River NNP cord-104204-pdnkabwj 19 20 , , , cord-104204-pdnkabwj 19 21 and and CC cord-104204-pdnkabwj 19 22 the the DT cord-104204-pdnkabwj 19 23 area area NN cord-104204-pdnkabwj 19 24 where where WRB cord-104204-pdnkabwj 19 25 the the DT cord-104204-pdnkabwj 19 26 disease disease NN cord-104204-pdnkabwj 19 27 occurs occur VBZ cord-104204-pdnkabwj 19 28 does do VBZ cord-104204-pdnkabwj 19 29 not not RB cord-104204-pdnkabwj 19 30 exceed exceed VB cord-104204-pdnkabwj 19 31 20,000 20,000 CD cord-104204-pdnkabwj 19 32 km2 km2 NN cord-104204-pdnkabwj 19 33 ( ( -LRB- cord-104204-pdnkabwj 19 34 2 2 CD cord-104204-pdnkabwj 19 35 ) ) -RRB- cord-104204-pdnkabwj 19 36 . . . cord-104204-pdnkabwj 20 1 The the DT cord-104204-pdnkabwj 20 2 topography topography NN cord-104204-pdnkabwj 20 3 of of IN cord-104204-pdnkabwj 20 4 the the DT cord-104204-pdnkabwj 20 5 disease disease NN cord-104204-pdnkabwj 20 6 sites site NNS cord-104204-pdnkabwj 20 7 varies vary VBZ cord-104204-pdnkabwj 20 8 from from IN cord-104204-pdnkabwj 20 9 the the DT cord-104204-pdnkabwj 20 10 flood flood NN cord-104204-pdnkabwj 20 11 plains plain NNS cord-104204-pdnkabwj 20 12 in in IN cord-104204-pdnkabwj 20 13 the the DT cord-104204-pdnkabwj 20 14 former former JJ cord-104204-pdnkabwj 20 15 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 20 16 to to IN cord-104204-pdnkabwj 20 17 the the DT cord-104204-pdnkabwj 20 18 undulating undulating JJ cord-104204-pdnkabwj 20 19 hills hill NNS cord-104204-pdnkabwj 20 20 around around IN cord-104204-pdnkabwj 20 21 Drobeta Drobeta NNP cord-104204-pdnkabwj 20 22 Turnu Turnu NNP cord-104204-pdnkabwj 20 23 Severin Severin NNP cord-104204-pdnkabwj 20 24 in in IN cord-104204-pdnkabwj 20 25 Romania Romania NNP cord-104204-pdnkabwj 20 26 and and CC cord-104204-pdnkabwj 20 27 the the DT cord-104204-pdnkabwj 20 28 low low JJ cord-104204-pdnkabwj 20 29 montane montane NN cord-104204-pdnkabwj 20 30 region region NN cord-104204-pdnkabwj 20 31 of of IN cord-104204-pdnkabwj 20 32 the the DT cord-104204-pdnkabwj 20 33 Vratza Vratza NNP cord-104204-pdnkabwj 20 34 District District NNP cord-104204-pdnkabwj 20 35 in in IN cord-104204-pdnkabwj 20 36 Bulgaria Bulgaria NNP cord-104204-pdnkabwj 20 37 ( ( -LRB- cord-104204-pdnkabwj 20 38 3 3 CD cord-104204-pdnkabwj 20 39 ) ) -RRB- cord-104204-pdnkabwj 21 1 ( ( -LRB- cord-104204-pdnkabwj 21 2 Fig Fig NNP cord-104204-pdnkabwj 21 3 . . NNP cord-104204-pdnkabwj 21 4 1 1 CD cord-104204-pdnkabwj 21 5 ) ) -RRB- cord-104204-pdnkabwj 21 6 . . . cord-104204-pdnkabwj 22 1 The the DT cord-104204-pdnkabwj 22 2 geographical geographical JJ cord-104204-pdnkabwj 22 3 distribution distribution NN cord-104204-pdnkabwj 22 4 of of IN cord-104204-pdnkabwj 22 5 the the DT cord-104204-pdnkabwj 22 6 disease disease NN cord-104204-pdnkabwj 22 7 has have VBZ cord-104204-pdnkabwj 22 8 not not RB cord-104204-pdnkabwj 22 9 changed change VBN cord-104204-pdnkabwj 22 10 significantly significantly RB cord-104204-pdnkabwj 22 11 since since IN cord-104204-pdnkabwj 22 12 it -PRON- PRP cord-104204-pdnkabwj 22 13 was be VBD cord-104204-pdnkabwj 22 14 first first RB cord-104204-pdnkabwj 22 15 described describe VBN cord-104204-pdnkabwj 22 16 in in IN cord-104204-pdnkabwj 22 17 the the DT cord-104204-pdnkabwj 22 18 1950s 1950 NNS cord-104204-pdnkabwj 22 19 . . . cord-104204-pdnkabwj 23 1 Villages village NNS cord-104204-pdnkabwj 23 2 afflicted afflict VBN cord-104204-pdnkabwj 23 3 in in IN cord-104204-pdnkabwj 23 4 the the DT cord-104204-pdnkabwj 23 5 past past NN cord-104204-pdnkabwj 23 6 continue continue VBP cord-104204-pdnkabwj 23 7 to to TO cord-104204-pdnkabwj 23 8 be be VB cord-104204-pdnkabwj 23 9 afflicted afflict VBN cord-104204-pdnkabwj 23 10 today today NN cord-104204-pdnkabwj 23 11 , , , cord-104204-pdnkabwj 23 12 while while IN cord-104204-pdnkabwj 23 13 nonendemic nonendemic NNP cord-104204-pdnkabwj 23 14 villages village NNS cord-104204-pdnkabwj 23 15 and and CC cord-104204-pdnkabwj 23 16 towns town NNS cord-104204-pdnkabwj 23 17 , , , cord-104204-pdnkabwj 23 18 sometimes sometimes RB cord-104204-pdnkabwj 23 19 located locate VBN cord-104204-pdnkabwj 23 20 in in IN cord-104204-pdnkabwj 23 21 close close JJ cord-104204-pdnkabwj 23 22 proximity proximity NN cord-104204-pdnkabwj 23 23 to to IN cord-104204-pdnkabwj 23 24 afflicted afflict VBN cord-104204-pdnkabwj 23 25 villages village NNS cord-104204-pdnkabwj 23 26 , , , cord-104204-pdnkabwj 23 27 have have VBP cord-104204-pdnkabwj 23 28 remained remain VBN cord-104204-pdnkabwj 23 29 free free JJ cord-104204-pdnkabwj 23 30 of of IN cord-104204-pdnkabwj 23 31 BEN BEN NNP cord-104204-pdnkabwj 23 32 . . . cord-104204-pdnkabwj 24 1 At at RB cord-104204-pdnkabwj 24 2 least least RBS cord-104204-pdnkabwj 24 3 25 25 CD cord-104204-pdnkabwj 24 4 , , , cord-104204-pdnkabwj 24 5 000 000 CD cord-104204-pdnkabwj 24 6 individuals individual NNS cord-104204-pdnkabwj 24 7 may may MD cord-104204-pdnkabwj 24 8 suffer suffer VB cord-104204-pdnkabwj 24 9 from from IN cord-104204-pdnkabwj 24 10 BEN BEN NNP cord-104204-pdnkabwj 24 11 or or CC cord-104204-pdnkabwj 24 12 are be VBP cord-104204-pdnkabwj 24 13 suspected suspect VBN cord-104204-pdnkabwj 24 14 of of IN cord-104204-pdnkabwj 24 15 having have VBG cord-104204-pdnkabwj 24 16 the the DT cord-104204-pdnkabwj 24 17 disease disease NN cord-104204-pdnkabwj 24 18 , , , cord-104204-pdnkabwj 24 19 while while IN cord-104204-pdnkabwj 24 20 the the DT cord-104204-pdnkabwj 24 21 total total JJ cord-104204-pdnkabwj 24 22 number number NN cord-104204-pdnkabwj 24 23 of of IN cord-104204-pdnkabwj 24 24 people people NNS cord-104204-pdnkabwj 24 25 at at IN cord-104204-pdnkabwj 24 26 risk risk NN cord-104204-pdnkabwj 24 27 in in IN cord-104204-pdnkabwj 24 28 the the DT cord-104204-pdnkabwj 24 29 three three CD cord-104204-pdnkabwj 24 30 countries country NNS cord-104204-pdnkabwj 24 31 may may MD cord-104204-pdnkabwj 24 32 exceed exceed VB cord-104204-pdnkabwj 24 33 100,000 100,000 CD cord-104204-pdnkabwj 24 34 ( ( -LRB- cord-104204-pdnkabwj 24 35 4 4 CD cord-104204-pdnkabwj 24 36 , , , cord-104204-pdnkabwj 24 37 5 5 CD cord-104204-pdnkabwj 24 38 ) ) -RRB- cord-104204-pdnkabwj 24 39 . . . cord-104204-pdnkabwj 25 1 Some some DT cord-104204-pdnkabwj 25 2 of of IN cord-104204-pdnkabwj 25 3 the the DT cord-104204-pdnkabwj 25 4 intriguing intriguing JJ cord-104204-pdnkabwj 25 5 features feature NNS cord-104204-pdnkabwj 25 6 of of IN cord-104204-pdnkabwj 25 7 BEN BEN NNP cord-104204-pdnkabwj 25 8 are be VBP cord-104204-pdnkabwj 25 9 1 1 CD cord-104204-pdnkabwj 25 10 ) ) -RRB- cord-104204-pdnkabwj 25 11 focal focal JJ cord-104204-pdnkabwj 25 12 occurrence occurrence NN cord-104204-pdnkabwj 25 13 of of IN cord-104204-pdnkabwj 25 14 the the DT cord-104204-pdnkabwj 25 15 clinical clinical JJ cord-104204-pdnkabwj 25 16 cases case NNS cord-104204-pdnkabwj 25 17 ; ; : cord-104204-pdnkabwj 25 18 2 2 LS cord-104204-pdnkabwj 25 19 ) ) -RRB- cord-104204-pdnkabwj 25 20 familial familial JJ cord-104204-pdnkabwj 25 21 aggregation aggregation NN cord-104204-pdnkabwj 25 22 without without IN cord-104204-pdnkabwj 25 23 an an DT cord-104204-pdnkabwj 25 24 obvious obvious JJ cord-104204-pdnkabwj 25 25 pattern pattern NN cord-104204-pdnkabwj 25 26 of of IN cord-104204-pdnkabwj 25 27 Mendelian mendelian JJ cord-104204-pdnkabwj 25 28 genetic genetic JJ cord-104204-pdnkabwj 25 29 inheritance inheritance NN cord-104204-pdnkabwj 25 30 ; ; : cord-104204-pdnkabwj 25 31 3 3 LS cord-104204-pdnkabwj 25 32 ) ) -RRB- cord-104204-pdnkabwj 25 33 long long JJ cord-104204-pdnkabwj 25 34 " " `` cord-104204-pdnkabwj 25 35 incubation incubation NN cord-104204-pdnkabwj 25 36 " " '' cord-104204-pdnkabwj 25 37 period period NN cord-104204-pdnkabwj 25 38 before before IN cord-104204-pdnkabwj 25 39 the the DT cord-104204-pdnkabwj 25 40 clinical clinical JJ cord-104204-pdnkabwj 25 41 onset onset NN cord-104204-pdnkabwj 25 42 of of IN cord-104204-pdnkabwj 25 43 the the DT cord-104204-pdnkabwj 25 44 disease disease NN cord-104204-pdnkabwj 25 45 ( ( -LRB- cord-104204-pdnkabwj 25 46 people people NNS cord-104204-pdnkabwj 25 47 coming come VBG cord-104204-pdnkabwj 25 48 from from IN cord-104204-pdnkabwj 25 49 outside outside NN cord-104204-pdnkabwj 25 50 must must MD cord-104204-pdnkabwj 25 51 reside reside VB cord-104204-pdnkabwj 25 52 in in IN cord-104204-pdnkabwj 25 53 the the DT cord-104204-pdnkabwj 25 54 endemic endemic JJ cord-104204-pdnkabwj 25 55 region region NN cord-104204-pdnkabwj 25 56 for for IN cord-104204-pdnkabwj 25 57 more more JJR cord-104204-pdnkabwj 25 58 than than IN cord-104204-pdnkabwj 25 59 10 10 CD cord-104204-pdnkabwj 25 60 - - SYM cord-104204-pdnkabwj 25 61 15 15 CD cord-104204-pdnkabwj 25 62 years year NNS cord-104204-pdnkabwj 25 63 to to TO cord-104204-pdnkabwj 25 64 acquire acquire VB cord-104204-pdnkabwj 25 65 the the DT cord-104204-pdnkabwj 25 66 disease disease NN cord-104204-pdnkabwj 25 67 ) ) -RRB- cord-104204-pdnkabwj 25 68 ; ; : cord-104204-pdnkabwj 25 69 4 4 LS cord-104204-pdnkabwj 25 70 ) ) -RRB- cord-104204-pdnkabwj 25 71 occurrence occurrence VB cord-104204-pdnkabwj 25 72 only only RB cord-104204-pdnkabwj 25 73 in in IN cord-104204-pdnkabwj 25 74 adults adult NNS cord-104204-pdnkabwj 25 75 ( ( -LRB- cord-104204-pdnkabwj 25 76 ages age NNS cord-104204-pdnkabwj 25 77 years year NNS cord-104204-pdnkabwj 25 78 are be VBP cord-104204-pdnkabwj 25 79 most most RBS cord-104204-pdnkabwj 25 80 heavily heavily RB cord-104204-pdnkabwj 25 81 affected affect VBN cord-104204-pdnkabwj 25 82 , , , cord-104204-pdnkabwj 25 83 while while IN cord-104204-pdnkabwj 25 84 almost almost RB cord-104204-pdnkabwj 25 85 no no DT cord-104204-pdnkabwj 25 86 children child NNS cord-104204-pdnkabwj 25 87 or or CC cord-104204-pdnkabwj 25 88 individuals individual NNS cord-104204-pdnkabwj 25 89 over over IN cord-104204-pdnkabwj 25 90 70 70 CD cord-104204-pdnkabwj 25 91 years year NNS cord-104204-pdnkabwj 25 92 of of IN cord-104204-pdnkabwj 25 93 age age NN cord-104204-pdnkabwj 25 94 develop develop VBP cord-104204-pdnkabwj 25 95 the the DT cord-104204-pdnkabwj 25 96 disease disease NN cord-104204-pdnkabwj 25 97 ) ) -RRB- cord-104204-pdnkabwj 25 98 ; ; : cord-104204-pdnkabwj 25 99 5 5 LS cord-104204-pdnkabwj 25 100 ) ) -RRB- cord-104204-pdnkabwj 25 101 a a DT cord-104204-pdnkabwj 25 102 slight slight JJ cord-104204-pdnkabwj 25 103 sex sex NN cord-104204-pdnkabwj 25 104 distribution distribution NN cord-104204-pdnkabwj 25 105 , , , cord-104204-pdnkabwj 25 106 with with IN cord-104204-pdnkabwj 25 107 a a DT cord-104204-pdnkabwj 25 108 female female JJ cord-104204-pdnkabwj 25 109 : : : cord-104204-pdnkabwj 25 110 male male JJ cord-104204-pdnkabwj 25 111 sex sex NN cord-104204-pdnkabwj 25 112 ratio ratio NN cord-104204-pdnkabwj 25 113 of of IN cord-104204-pdnkabwj 25 114 about about IN cord-104204-pdnkabwj 25 115 1.5:1 1.5:1 CD cord-104204-pdnkabwj 25 116 ; ; : cord-104204-pdnkabwj 25 117 6 6 CD cord-104204-pdnkabwj 25 118 ) ) -RRB- cord-104204-pdnkabwj 25 119 a a DT cord-104204-pdnkabwj 25 120 similar similar JJ cord-104204-pdnkabwj 25 121 incidence incidence NN cord-104204-pdnkabwj 25 122 in in IN cord-104204-pdnkabwj 25 123 different different JJ cord-104204-pdnkabwj 25 124 ethnic ethnic JJ cord-104204-pdnkabwj 25 125 and and CC cord-104204-pdnkabwj 25 126 religious religious JJ cord-104204-pdnkabwj 25 127 groups group NNS cord-104204-pdnkabwj 25 128 ; ; : cord-104204-pdnkabwj 25 129 and and CC cord-104204-pdnkabwj 25 130 7 7 CD cord-104204-pdnkabwj 25 131 ) ) -RRB- cord-104204-pdnkabwj 25 132 restriction restriction NN cord-104204-pdnkabwj 25 133 to to IN cord-104204-pdnkabwj 25 134 a a DT cord-104204-pdnkabwj 25 135 rural rural JJ cord-104204-pdnkabwj 25 136 farming farming NN cord-104204-pdnkabwj 25 137 population population NN cord-104204-pdnkabwj 25 138 . . . cord-104204-pdnkabwj 26 1 Of of IN cord-104204-pdnkabwj 26 2 particular particular JJ cord-104204-pdnkabwj 26 3 interest interest NN cord-104204-pdnkabwj 26 4 are be VBP cord-104204-pdnkabwj 26 5 the the DT cord-104204-pdnkabwj 26 6 upper upper JJ cord-104204-pdnkabwj 26 7 urinary urinary JJ cord-104204-pdnkabwj 26 8 tract tract NN cord-104204-pdnkabwj 26 9 tumors tumor NNS cord-104204-pdnkabwj 26 10 ( ( -LRB- cord-104204-pdnkabwj 26 11 UTTs utt NNS cord-104204-pdnkabwj 26 12 ) ) -RRB- cord-104204-pdnkabwj 26 13 seen see VBN cord-104204-pdnkabwj 26 14 in in IN cord-104204-pdnkabwj 26 15 BEN BEN NNP cord-104204-pdnkabwj 26 16 patients patient NNS cord-104204-pdnkabwj 26 17 at at IN cord-104204-pdnkabwj 26 18 frequencies frequency NNS cord-104204-pdnkabwj 26 19 much much RB cord-104204-pdnkabwj 26 20 higher high JJR cord-104204-pdnkabwj 26 21 than than IN cord-104204-pdnkabwj 26 22 in in IN cord-104204-pdnkabwj 26 23 individuals individual NNS cord-104204-pdnkabwj 26 24 not not RB cord-104204-pdnkabwj 26 25 suffering suffer VBG cord-104204-pdnkabwj 26 26 from from IN cord-104204-pdnkabwj 26 27 BEN BEN NNP cord-104204-pdnkabwj 26 28 from from IN cord-104204-pdnkabwj 26 29 endemic endemic JJ cord-104204-pdnkabwj 26 30 regions region NNS cord-104204-pdnkabwj 26 31 or or CC cord-104204-pdnkabwj 26 32 in in IN cord-104204-pdnkabwj 26 33 the the DT cord-104204-pdnkabwj 26 34 general general JJ cord-104204-pdnkabwj 26 35 population population NN cord-104204-pdnkabwj 26 36 in in IN cord-104204-pdnkabwj 26 37 the the DT cord-104204-pdnkabwj 26 38 countries country NNS cord-104204-pdnkabwj 26 39 with with IN cord-104204-pdnkabwj 26 40 BEN BEN NNP cord-104204-pdnkabwj 26 41 . . . cord-104204-pdnkabwj 27 1 The the DT cord-104204-pdnkabwj 27 2 distribution distribution NN cord-104204-pdnkabwj 27 3 of of IN cord-104204-pdnkabwj 27 4 these these DT cord-104204-pdnkabwj 27 5 tumors tumor NNS cord-104204-pdnkabwj 27 6 generally generally RB cord-104204-pdnkabwj 27 7 follows follow VBZ cord-104204-pdnkabwj 27 8 the the DT cord-104204-pdnkabwj 27 9 geographical geographical JJ cord-104204-pdnkabwj 27 10 distribution distribution NN cord-104204-pdnkabwj 27 11 of of IN cord-104204-pdnkabwj 27 12 BEN BEN NNP cord-104204-pdnkabwj 27 13 , , , cord-104204-pdnkabwj 27 14 with with IN cord-104204-pdnkabwj 27 15 a a DT cord-104204-pdnkabwj 27 16 steep steep JJ cord-104204-pdnkabwj 27 17 decrease decrease NN cord-104204-pdnkabwj 27 18 in in IN cord-104204-pdnkabwj 27 19 incidence incidence NN cord-104204-pdnkabwj 27 20 in in IN cord-104204-pdnkabwj 27 21 nonendemic nonendemic NNP cord-104204-pdnkabwj 27 22 villages village NNS cord-104204-pdnkabwj 27 23 located locate VBN cord-104204-pdnkabwj 27 24 even even RB cord-104204-pdnkabwj 27 25 1 1 CD cord-104204-pdnkabwj 27 26 - - SYM cord-104204-pdnkabwj 27 27 2 2 CD cord-104204-pdnkabwj 27 28 miles mile NNS cord-104204-pdnkabwj 27 29 away away RB cord-104204-pdnkabwj 27 30 from from IN cord-104204-pdnkabwj 27 31 the the DT cord-104204-pdnkabwj 27 32 endemic endemic JJ cord-104204-pdnkabwj 27 33 ones one NNS cord-104204-pdnkabwj 27 34 . . . cord-104204-pdnkabwj 28 1 UTTs utt NNS cord-104204-pdnkabwj 28 2 are be VBP cord-104204-pdnkabwj 28 3 frequently frequently RB cord-104204-pdnkabwj 28 4 multiple multiple JJ cord-104204-pdnkabwj 28 5 and and CC cord-104204-pdnkabwj 28 6 bilateral bilateral JJ cord-104204-pdnkabwj 28 7 and and CC cord-104204-pdnkabwj 28 8 rarely rarely RB cord-104204-pdnkabwj 28 9 occur occur VBP cord-104204-pdnkabwj 28 10 in in IN cord-104204-pdnkabwj 28 11 the the DT cord-104204-pdnkabwj 28 12 general general JJ cord-104204-pdnkabwj 28 13 population population NN cord-104204-pdnkabwj 28 14 . . . cord-104204-pdnkabwj 29 1 Their -PRON- PRP$ cord-104204-pdnkabwj 29 2 high high JJ cord-104204-pdnkabwj 29 3 incidence incidence NN cord-104204-pdnkabwj 29 4 in in IN cord-104204-pdnkabwj 29 5 BEN BEN NNP cord-104204-pdnkabwj 29 6 patients patient NNS cord-104204-pdnkabwj 29 7 led lead VBD cord-104204-pdnkabwj 29 8 to to IN cord-104204-pdnkabwj 29 9 speculation speculation NN cord-104204-pdnkabwj 29 10 that that IN cord-104204-pdnkabwj 29 11 the the DT cord-104204-pdnkabwj 29 12 two two CD cord-104204-pdnkabwj 29 13 diseases disease NNS cord-104204-pdnkabwj 29 14 could could MD cord-104204-pdnkabwj 29 15 be be VB cord-104204-pdnkabwj 29 16 causally causally RB cord-104204-pdnkabwj 29 17 related relate VBN cord-104204-pdnkabwj 29 18 ( ( -LRB- cord-104204-pdnkabwj 29 19 1 1 CD cord-104204-pdnkabwj 29 20 ) ) -RRB- cord-104204-pdnkabwj 29 21 or or CC cord-104204-pdnkabwj 29 22 that that IN cord-104204-pdnkabwj 29 23 the the DT cord-104204-pdnkabwj 29 24 urinary urinary JJ cord-104204-pdnkabwj 29 25 tract tract NN cord-104204-pdnkabwj 29 26 tumors tumor NNS cord-104204-pdnkabwj 29 27 should should MD cord-104204-pdnkabwj 29 28 be be VB cord-104204-pdnkabwj 29 29 seen see VBN cord-104204-pdnkabwj 29 30 as as IN cord-104204-pdnkabwj 29 31 a a DT cord-104204-pdnkabwj 29 32 symptom symptom NN cord-104204-pdnkabwj 29 33 , , , cord-104204-pdnkabwj 29 34 although although IN cord-104204-pdnkabwj 29 35 inconstant inconstant JJ cord-104204-pdnkabwj 29 36 , , , cord-104204-pdnkabwj 29 37 of of IN cord-104204-pdnkabwj 29 38 BEN BEN NNP cord-104204-pdnkabwj 29 39 . . . cord-104204-pdnkabwj 30 1 There there EX cord-104204-pdnkabwj 30 2 have have VBP cord-104204-pdnkabwj 30 3 been be VBN cord-104204-pdnkabwj 30 4 several several JJ cord-104204-pdnkabwj 30 5 attempts attempt NNS cord-104204-pdnkabwj 30 6 to to TO cord-104204-pdnkabwj 30 7 trace trace VB cord-104204-pdnkabwj 30 8 the the DT cord-104204-pdnkabwj 30 9 history history NN cord-104204-pdnkabwj 30 10 of of IN cord-104204-pdnkabwj 30 11 endemic endemic JJ cord-104204-pdnkabwj 30 12 nephropathy nephropathy NN cord-104204-pdnkabwj 30 13 to to IN cord-104204-pdnkabwj 30 14 the the DT cord-104204-pdnkabwj 30 15 beginnings beginning NNS cord-104204-pdnkabwj 30 16 of of IN cord-104204-pdnkabwj 30 17 this this DT cord-104204-pdnkabwj 30 18 century century NN cord-104204-pdnkabwj 30 19 or or CC cord-104204-pdnkabwj 30 20 to to IN cord-104204-pdnkabwj 30 21 the the DT cord-104204-pdnkabwj 30 22 period period NN cord-104204-pdnkabwj 30 23 between between IN cord-104204-pdnkabwj 30 24 the the DT cord-104204-pdnkabwj 30 25 two two CD cord-104204-pdnkabwj 30 26 world world NN cord-104204-pdnkabwj 30 27 wars war NNS cord-104204-pdnkabwj 30 28 . . . cord-104204-pdnkabwj 31 1 Because because IN cord-104204-pdnkabwj 31 2 BEN BEN NNP cord-104204-pdnkabwj 31 3 becomes become VBZ cord-104204-pdnkabwj 31 4 manifest manifest NN cord-104204-pdnkabwj 31 5 at at IN cord-104204-pdnkabwj 31 6 older old JJR cord-104204-pdnkabwj 31 7 ages age NNS cord-104204-pdnkabwj 31 8 and and CC cord-104204-pdnkabwj 31 9 the the DT cord-104204-pdnkabwj 31 10 average average JJ cord-104204-pdnkabwj 31 11 life life NN cord-104204-pdnkabwj 31 12 expectancy expectancy NN cord-104204-pdnkabwj 31 13 in in IN cord-104204-pdnkabwj 31 14 the the DT cord-104204-pdnkabwj 31 15 endemic endemic JJ cord-104204-pdnkabwj 31 16 settlements settlement NNS cord-104204-pdnkabwj 31 17 was be VBD cord-104204-pdnkabwj 31 18 less less JJR cord-104204-pdnkabwj 31 19 than than IN cord-104204-pdnkabwj 31 20 45 45 CD cord-104204-pdnkabwj 31 21 - - SYM cord-104204-pdnkabwj 31 22 50 50 CD cord-104204-pdnkabwj 31 23 years year NNS cord-104204-pdnkabwj 31 24 before before IN cord-104204-pdnkabwj 31 25 World World NNP cord-104204-pdnkabwj 31 26 War War NNP cord-104204-pdnkabwj 31 27 II II NNP cord-104204-pdnkabwj 31 28 ( ( -LRB- cord-104204-pdnkabwj 31 29 some some DT cord-104204-pdnkabwj 31 30 of of IN cord-104204-pdnkabwj 31 31 the the DT cord-104204-pdnkabwj 31 32 major major JJ cord-104204-pdnkabwj 31 33 causes cause NNS cord-104204-pdnkabwj 31 34 of of IN cord-104204-pdnkabwj 31 35 earlier early JJR cord-104204-pdnkabwj 31 36 death death NN cord-104204-pdnkabwj 31 37 were be VBD cord-104204-pdnkabwj 31 38 parasitic parasitic JJ cord-104204-pdnkabwj 31 39 or or CC cord-104204-pdnkabwj 31 40 infectious infectious JJ cord-104204-pdnkabwj 31 41 diseases disease NNS cord-104204-pdnkabwj 31 42 such such JJ cord-104204-pdnkabwj 31 43 as as IN cord-104204-pdnkabwj 31 44 malaria malaria NN cord-104204-pdnkabwj 31 45 and and CC cord-104204-pdnkabwj 31 46 tuberculosis tuberculosis NN cord-104204-pdnkabwj 31 47 ) ) -RRB- cord-104204-pdnkabwj 31 48 , , , cord-104204-pdnkabwj 31 49 no no DT cord-104204-pdnkabwj 31 50 rigorous rigorous JJ cord-104204-pdnkabwj 31 51 description description NN cord-104204-pdnkabwj 31 52 of of IN cord-104204-pdnkabwj 31 53 the the DT cord-104204-pdnkabwj 31 54 disease disease NN cord-104204-pdnkabwj 31 55 or or CC cord-104204-pdnkabwj 31 56 clue clue NN cord-104204-pdnkabwj 31 57 it -PRON- PRP cord-104204-pdnkabwj 31 58 existed exist VBD cord-104204-pdnkabwj 31 59 is be VBZ cord-104204-pdnkabwj 31 60 available available JJ cord-104204-pdnkabwj 31 61 from from IN cord-104204-pdnkabwj 31 62 that that DT cord-104204-pdnkabwj 31 63 period period NN cord-104204-pdnkabwj 31 64 ( ( -LRB- cord-104204-pdnkabwj 31 65 6 6 CD cord-104204-pdnkabwj 31 66 ) ) -RRB- cord-104204-pdnkabwj 31 67 . . . cord-104204-pdnkabwj 32 1 This this DT cord-104204-pdnkabwj 32 2 , , , cord-104204-pdnkabwj 32 3 however however RB cord-104204-pdnkabwj 32 4 , , , cord-104204-pdnkabwj 32 5 does do VBZ cord-104204-pdnkabwj 32 6 not not RB cord-104204-pdnkabwj 32 7 preclude preclude VB cord-104204-pdnkabwj 32 8 the the DT cord-104204-pdnkabwj 32 9 possibility possibility NN cord-104204-pdnkabwj 32 10 that that IN cord-104204-pdnkabwj 32 11 the the DT cord-104204-pdnkabwj 32 12 etiological etiological JJ cord-104204-pdnkabwj 32 13 factor(s factor(s NNP cord-104204-pdnkabwj 32 14 ) ) -RRB- cord-104204-pdnkabwj 32 15 responsible responsible JJ cord-104204-pdnkabwj 32 16 for for IN cord-104204-pdnkabwj 32 17 BEN BEN NNP cord-104204-pdnkabwj 32 18 has have VBZ cord-104204-pdnkabwj 32 19 been be VBN cord-104204-pdnkabwj 32 20 present present JJ cord-104204-pdnkabwj 32 21 in in IN cord-104204-pdnkabwj 32 22 endemic endemic JJ cord-104204-pdnkabwj 32 23 areas area NNS cord-104204-pdnkabwj 32 24 for for IN cord-104204-pdnkabwj 32 25 centuries century NNS cord-104204-pdnkabwj 32 26 or or CC cord-104204-pdnkabwj 32 27 millennia millennium NNS cord-104204-pdnkabwj 32 28 . . . cord-104204-pdnkabwj 33 1 The the DT cord-104204-pdnkabwj 33 2 increase increase NN cord-104204-pdnkabwj 33 3 in in IN cord-104204-pdnkabwj 33 4 the the DT cord-104204-pdnkabwj 33 5 average average JJ cord-104204-pdnkabwj 33 6 life life NN cord-104204-pdnkabwj 33 7 expectancy expectancy NN cord-104204-pdnkabwj 33 8 after after IN cord-104204-pdnkabwj 33 9 World World NNP cord-104204-pdnkabwj 33 10 War War NNP cord-104204-pdnkabwj 33 11 II II NNP cord-104204-pdnkabwj 33 12 may may MD cord-104204-pdnkabwj 33 13 have have VB cord-104204-pdnkabwj 33 14 allowed allow VBN cord-104204-pdnkabwj 33 15 BEN BEN NNP cord-104204-pdnkabwj 33 16 to to TO cord-104204-pdnkabwj 33 17 become become VB cord-104204-pdnkabwj 33 18 manifest manifest JJ cord-104204-pdnkabwj 33 19 and and CC cord-104204-pdnkabwj 33 20 thereafter thereafter RB cord-104204-pdnkabwj 33 21 to to TO cord-104204-pdnkabwj 33 22 be be VB cord-104204-pdnkabwj 33 23 described describe VBN cord-104204-pdnkabwj 33 24 as as IN cord-104204-pdnkabwj 33 25 a a DT cord-104204-pdnkabwj 33 26 distinct distinct JJ cord-104204-pdnkabwj 33 27 nosological nosological JJ cord-104204-pdnkabwj 33 28 entity entity NN cord-104204-pdnkabwj 33 29 . . . cord-104204-pdnkabwj 34 1 BEN BEN NNP cord-104204-pdnkabwj 34 2 was be VBD cord-104204-pdnkabwj 34 3 almost almost RB cord-104204-pdnkabwj 34 4 simultaneously simultaneously RB cord-104204-pdnkabwj 34 5 recognized recognize VBN cord-104204-pdnkabwj 34 6 for for IN cord-104204-pdnkabwj 34 7 the the DT cord-104204-pdnkabwj 34 8 first first JJ cord-104204-pdnkabwj 34 9 time time NN cord-104204-pdnkabwj 34 10 in in IN cord-104204-pdnkabwj 34 11 the the DT cord-104204-pdnkabwj 34 12 three three CD cord-104204-pdnkabwj 34 13 countries country NNS cord-104204-pdnkabwj 34 14 involved involve VBN cord-104204-pdnkabwj 34 15 as as RB cord-104204-pdnkabwj 34 16 well well RB cord-104204-pdnkabwj 34 17 as as IN cord-104204-pdnkabwj 34 18 in in IN cord-104204-pdnkabwj 34 19 each each DT cord-104204-pdnkabwj 34 20 major major JJ cord-104204-pdnkabwj 34 21 affected affected JJ cord-104204-pdnkabwj 34 22 region region NN cord-104204-pdnkabwj 34 23 of of IN cord-104204-pdnkabwj 34 24 these these DT cord-104204-pdnkabwj 34 25 countries country NNS cord-104204-pdnkabwj 34 26 by by IN cord-104204-pdnkabwj 34 27 Tanchev Tanchev NNP cord-104204-pdnkabwj 34 28 et et NNP cord-104204-pdnkabwj 34 29 al al NNP cord-104204-pdnkabwj 34 30 . . . cord-104204-pdnkabwj 35 1 in in IN cord-104204-pdnkabwj 35 2 Bulgaria Bulgaria NNP cord-104204-pdnkabwj 35 3 in in IN cord-104204-pdnkabwj 35 4 1956 1956 CD cord-104204-pdnkabwj 35 5 ( ( -LRB- cord-104204-pdnkabwj 35 6 7 7 CD cord-104204-pdnkabwj 35 7 ) ) -RRB- cord-104204-pdnkabwj 35 8 , , , cord-104204-pdnkabwj 35 9 by by IN cord-104204-pdnkabwj 35 10 Danilovic Danilovic NNP cord-104204-pdnkabwj 35 11 and and CC cord-104204-pdnkabwj 35 12 others other NNS cord-104204-pdnkabwj 35 13 in in IN cord-104204-pdnkabwj 35 14 1957 1957 CD cord-104204-pdnkabwj 35 15 in in IN cord-104204-pdnkabwj 35 16 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 35 17 ( ( -LRB- cord-104204-pdnkabwj 35 18 8) 8) NNP cord-104204-pdnkabwj 35 19 , , , cord-104204-pdnkabwj 35 20 and and CC cord-104204-pdnkabwj 35 21 by by IN cord-104204-pdnkabwj 35 22 Fortza Fortza NNP cord-104204-pdnkabwj 35 23 and and CC cord-104204-pdnkabwj 35 24 Negoescu Negoescu NNP cord-104204-pdnkabwj 35 25 in in IN cord-104204-pdnkabwj 35 26 Romania Romania NNP cord-104204-pdnkabwj 35 27 in in IN cord-104204-pdnkabwj 35 28 1961 1961 CD cord-104204-pdnkabwj 35 29 ( ( -LRB- cord-104204-pdnkabwj 35 30 5 5 CD cord-104204-pdnkabwj 35 31 . . . cord-104204-pdnkabwj 36 1 In in IN cord-104204-pdnkabwj 36 2 spite spite NN cord-104204-pdnkabwj 36 3 of of IN cord-104204-pdnkabwj 36 4 considerable considerable JJ cord-104204-pdnkabwj 36 5 research research NN cord-104204-pdnkabwj 36 6 performed perform VBN cord-104204-pdnkabwj 36 7 in in IN cord-104204-pdnkabwj 36 8 the the DT cord-104204-pdnkabwj 36 9 three three CD cord-104204-pdnkabwj 36 10 afflicted afflict VBN cord-104204-pdnkabwj 36 11 countries country NNS cord-104204-pdnkabwj 36 12 , , , cord-104204-pdnkabwj 36 13 the the DT cord-104204-pdnkabwj 36 14 etiology etiology NN cord-104204-pdnkabwj 36 15 of of IN cord-104204-pdnkabwj 36 16 BEN BEN NNP cord-104204-pdnkabwj 36 17 and and CC cord-104204-pdnkabwj 36 18 of of IN cord-104204-pdnkabwj 36 19 its -PRON- PRP$ cord-104204-pdnkabwj 36 20 accompanying accompany VBG cord-104204-pdnkabwj 36 21 uroepithelial uroepithelial JJ cord-104204-pdnkabwj 36 22 tumors tumor NNS cord-104204-pdnkabwj 36 23 still still RB cord-104204-pdnkabwj 36 24 remains remain VBZ cord-104204-pdnkabwj 36 25 a a DT cord-104204-pdnkabwj 36 26 medical medical JJ cord-104204-pdnkabwj 36 27 enigma enigma NN cord-104204-pdnkabwj 36 28 . . . cord-104204-pdnkabwj 37 1 Multidisciplinary multidisciplinary JJ cord-104204-pdnkabwj 37 2 studies study NNS cord-104204-pdnkabwj 37 3 involving involve VBG cord-104204-pdnkabwj 37 4 environmental environmental JJ cord-104204-pdnkabwj 37 5 and and CC cord-104204-pdnkabwj 37 6 occupational occupational JJ cord-104204-pdnkabwj 37 7 medicine medicine NN cord-104204-pdnkabwj 37 8 , , , cord-104204-pdnkabwj 37 9 microbiology microbiology NN cord-104204-pdnkabwj 37 10 , , , cord-104204-pdnkabwj 37 11 oncology oncology NN cord-104204-pdnkabwj 37 12 , , , cord-104204-pdnkabwj 37 13 toxicology toxicology NN cord-104204-pdnkabwj 37 14 , , , cord-104204-pdnkabwj 37 15 epidemiology epidemiology NN cord-104204-pdnkabwj 37 16 , , , cord-104204-pdnkabwj 37 17 cytogenetics cytogenetic NNS cord-104204-pdnkabwj 37 18 , , , cord-104204-pdnkabwj 37 19 and and CC cord-104204-pdnkabwj 37 20 more more RBR cord-104204-pdnkabwj 37 21 recently recently RB cord-104204-pdnkabwj 37 22 , , , cord-104204-pdnkabwj 37 23 geology geology NN cord-104204-pdnkabwj 37 24 , , , cord-104204-pdnkabwj 37 25 hydrogeology hydrogeology NN cord-104204-pdnkabwj 37 26 , , , cord-104204-pdnkabwj 37 27 and and CC cord-104204-pdnkabwj 37 28 biogeochemistry biogeochemistry NN cord-104204-pdnkabwj 37 29 have have VBP cord-104204-pdnkabwj 37 30 added add VBN cord-104204-pdnkabwj 37 31 some some DT cord-104204-pdnkabwj 37 32 pieces piece NNS cord-104204-pdnkabwj 37 33 to to IN cord-104204-pdnkabwj 37 34 the the DT cord-104204-pdnkabwj 37 35 puzzle puzzle NN cord-104204-pdnkabwj 37 36 , , , cord-104204-pdnkabwj 37 37 but but CC cord-104204-pdnkabwj 37 38 have have VBP cord-104204-pdnkabwj 37 39 also also RB cord-104204-pdnkabwj 37 40 raised raise VBN cord-104204-pdnkabwj 37 41 new new JJ cord-104204-pdnkabwj 37 42 questions question NNS cord-104204-pdnkabwj 37 43 ( ( -LRB- cord-104204-pdnkabwj 37 44 10 10 CD cord-104204-pdnkabwj 37 45 ) ) -RRB- cord-104204-pdnkabwj 37 46 . . . cord-104204-pdnkabwj 38 1 Among among IN cord-104204-pdnkabwj 38 2 these these DT cord-104204-pdnkabwj 38 3 , , , cord-104204-pdnkabwj 38 4 the the DT cord-104204-pdnkabwj 38 5 most most RBS cord-104204-pdnkabwj 38 6 central central JJ cord-104204-pdnkabwj 38 7 remains remain NNS cord-104204-pdnkabwj 38 8 : : : cord-104204-pdnkabwj 39 1 What what WP cord-104204-pdnkabwj 39 2 is be VBZ cord-104204-pdnkabwj 39 3 the the DT cord-104204-pdnkabwj 39 4 true true JJ cord-104204-pdnkabwj 39 5 cause cause NN cord-104204-pdnkabwj 39 6 of of IN cord-104204-pdnkabwj 39 7 the the DT cord-104204-pdnkabwj 39 8 disease disease NN cord-104204-pdnkabwj 39 9 ? ? . cord-104204-pdnkabwj 40 1 Clinical clinical JJ cord-104204-pdnkabwj 40 2 Presentation Presentation NNP cord-104204-pdnkabwj 40 3 and and CC cord-104204-pdnkabwj 40 4 Laboratory Laboratory NNP cord-104204-pdnkabwj 40 5 Findings Findings NNPS cord-104204-pdnkabwj 40 6 in in IN cord-104204-pdnkabwj 40 7 BEN BEN NNP cord-104204-pdnkabwj 40 8 BEN BEN NNP cord-104204-pdnkabwj 40 9 is be VBZ cord-104204-pdnkabwj 40 10 a a DT cord-104204-pdnkabwj 40 11 progressive progressive JJ cord-104204-pdnkabwj 40 12 kidney kidney NN cord-104204-pdnkabwj 40 13 disease disease NN cord-104204-pdnkabwj 40 14 inexorably inexorably RB cord-104204-pdnkabwj 40 15 leading lead VBG cord-104204-pdnkabwj 40 16 to to IN cord-104204-pdnkabwj 40 17 end end VB cord-104204-pdnkabwj 40 18 stage stage NN cord-104204-pdnkabwj 40 19 renal renal JJ cord-104204-pdnkabwj 40 20 failure failure NN cord-104204-pdnkabwj 40 21 . . . cord-104204-pdnkabwj 41 1 Although although IN cord-104204-pdnkabwj 41 2 some some DT cord-104204-pdnkabwj 41 3 symptoms symptom NNS cord-104204-pdnkabwj 41 4 seem seem VBP cord-104204-pdnkabwj 41 5 to to TO cord-104204-pdnkabwj 41 6 be be VB cord-104204-pdnkabwj 41 7 more more RBR cord-104204-pdnkabwj 41 8 specific specific JJ cord-104204-pdnkabwj 41 9 , , , cord-104204-pdnkabwj 41 10 there there EX cord-104204-pdnkabwj 41 11 is be VBZ cord-104204-pdnkabwj 41 12 no no DT cord-104204-pdnkabwj 41 13 clear clear RB cord-104204-pdnkabwj 41 14 - - HYPH cord-104204-pdnkabwj 41 15 cut cut VBN cord-104204-pdnkabwj 41 16 clinical clinical JJ cord-104204-pdnkabwj 41 17 or or CC cord-104204-pdnkabwj 41 18 pathological pathological JJ cord-104204-pdnkabwj 41 19 definition definition NN cord-104204-pdnkabwj 41 20 that that WDT cord-104204-pdnkabwj 41 21 is be VBZ cord-104204-pdnkabwj 41 22 solely solely RB cord-104204-pdnkabwj 41 23 sufficient sufficient JJ cord-104204-pdnkabwj 41 24 for for IN cord-104204-pdnkabwj 41 25 disease disease NN cord-104204-pdnkabwj 41 26 diagnosis diagnosis NN cord-104204-pdnkabwj 41 27 . . . cord-104204-pdnkabwj 42 1 The the DT cord-104204-pdnkabwj 42 2 onset onset NN cord-104204-pdnkabwj 42 3 is be VBZ cord-104204-pdnkabwj 42 4 without without IN cord-104204-pdnkabwj 42 5 any any DT cord-104204-pdnkabwj 42 6 acute acute JJ cord-104204-pdnkabwj 42 7 episode episode NN cord-104204-pdnkabwj 42 8 , , , cord-104204-pdnkabwj 42 9 and and CC cord-104204-pdnkabwj 42 10 the the DT cord-104204-pdnkabwj 42 11 anecdotal anecdotal JJ cord-104204-pdnkabwj 42 12 cases case NNS cord-104204-pdnkabwj 42 13 of of IN cord-104204-pdnkabwj 42 14 acute acute JJ cord-104204-pdnkabwj 42 15 BEN BEN NNP cord-104204-pdnkabwj 42 16 described describe VBD cord-104204-pdnkabwj 42 17 in in IN cord-104204-pdnkabwj 42 18 the the DT cord-104204-pdnkabwj 42 19 literature literature NN cord-104204-pdnkabwj 42 20 seem seem VBP cord-104204-pdnkabwj 42 21 to to TO cord-104204-pdnkabwj 42 22 be be VB cord-104204-pdnkabwj 42 23 related relate VBN cord-104204-pdnkabwj 42 24 to to IN cord-104204-pdnkabwj 42 25 kidney kidney NN cord-104204-pdnkabwj 42 26 diseases disease NNS cord-104204-pdnkabwj 42 27 other other JJ cord-104204-pdnkabwj 42 28 than than IN cord-104204-pdnkabwj 42 29 BEN BEN NNP cord-104204-pdnkabwj 42 30 ( ( -LRB- cord-104204-pdnkabwj 42 31 or or CC cord-104204-pdnkabwj 42 32 going go VBG cord-104204-pdnkabwj 42 33 along along RP cord-104204-pdnkabwj 42 34 with with IN cord-104204-pdnkabwj 42 35 BEN BEN NNP cord-104204-pdnkabwj 42 36 ) ) -RRB- cord-104204-pdnkabwj 42 37 that that WDT cord-104204-pdnkabwj 42 38 may may MD cord-104204-pdnkabwj 42 39 occur occur VB cord-104204-pdnkabwj 42 40 in in IN cord-104204-pdnkabwj 42 41 the the DT cord-104204-pdnkabwj 42 42 endemic endemic JJ cord-104204-pdnkabwj 42 43 regions region NNS cord-104204-pdnkabwj 42 44 . . . cord-104204-pdnkabwj 43 1 The the DT cord-104204-pdnkabwj 43 2 disease disease NN cord-104204-pdnkabwj 43 3 progresses progress VBZ cord-104204-pdnkabwj 43 4 slowly slowly RB cord-104204-pdnkabwj 43 5 with with IN cord-104204-pdnkabwj 43 6 the the DT cord-104204-pdnkabwj 43 7 occurrence occurrence NN cord-104204-pdnkabwj 43 8 of of IN cord-104204-pdnkabwj 43 9 nonspecific nonspecific JJ cord-104204-pdnkabwj 43 10 signs sign NNS cord-104204-pdnkabwj 43 11 ( ( -LRB- cord-104204-pdnkabwj 43 12 lassitude lassitude NN cord-104204-pdnkabwj 43 13 , , , cord-104204-pdnkabwj 43 14 fatigue fatigue NN cord-104204-pdnkabwj 43 15 , , , cord-104204-pdnkabwj 43 16 headache headache NN cord-104204-pdnkabwj 43 17 , , , cord-104204-pdnkabwj 43 18 weight weight NN cord-104204-pdnkabwj 43 19 loss loss NN cord-104204-pdnkabwj 43 20 and and CC cord-104204-pdnkabwj 43 21 reduced reduce VBN cord-104204-pdnkabwj 43 22 appetite appetite NN cord-104204-pdnkabwj 43 23 , , , cord-104204-pdnkabwj 43 24 xanthochromic xanthochromic NNP cord-104204-pdnkabwj 43 25 or or CC cord-104204-pdnkabwj 43 26 pale pale JJ cord-104204-pdnkabwj 43 27 skin skin NN cord-104204-pdnkabwj 43 28 ) ) -RRB- cord-104204-pdnkabwj 43 29 and and CC cord-104204-pdnkabwj 43 30 specific specific JJ cord-104204-pdnkabwj 43 31 signs sign NNS cord-104204-pdnkabwj 43 32 of of IN cord-104204-pdnkabwj 43 33 kidney kidney NN cord-104204-pdnkabwj 43 34 damage damage NN cord-104204-pdnkabwj 43 35 ( ( -LRB- cord-104204-pdnkabwj 43 36 reduced reduce VBN cord-104204-pdnkabwj 43 37 tubular tubular JJ cord-104204-pdnkabwj 43 38 transport transport NN cord-104204-pdnkabwj 43 39 , , , cord-104204-pdnkabwj 43 40 intermittent intermittent JJ cord-104204-pdnkabwj 43 41 proteinuria proteinuria NN cord-104204-pdnkabwj 43 42 with with IN cord-104204-pdnkabwj 43 43 low low JJ cord-104204-pdnkabwj 43 44 molecular molecular JJ cord-104204-pdnkabwj 43 45 weight weight NN cord-104204-pdnkabwj 43 46 proteins protein NNS cord-104204-pdnkabwj 43 47 such such JJ cord-104204-pdnkabwj 43 48 as as IN cord-104204-pdnkabwj 43 49 [ [ -LRB- cord-104204-pdnkabwj 43 50 -2 -2 NNP cord-104204-pdnkabwj 43 51 microglobulin microglobulin NN cord-104204-pdnkabwj 43 52 , , , cord-104204-pdnkabwj 43 53 and and CC cord-104204-pdnkabwj 43 54 a a DT cord-104204-pdnkabwj 43 55 gradual gradual JJ cord-104204-pdnkabwj 43 56 rise rise NN cord-104204-pdnkabwj 43 57 in in IN cord-104204-pdnkabwj 43 58 blood blood NN cord-104204-pdnkabwj 43 59 nitrogen nitrogen NN cord-104204-pdnkabwj 43 60 ) ) -RRB- cord-104204-pdnkabwj 43 61 ( ( -LRB- cord-104204-pdnkabwj 43 62 11 11 CD cord-104204-pdnkabwj 43 63 ) ) -RRB- cord-104204-pdnkabwj 43 64 . . . cord-104204-pdnkabwj 44 1 Usually usually RB cord-104204-pdnkabwj 44 2 , , , cord-104204-pdnkabwj 44 3 no no DT cord-104204-pdnkabwj 44 4 increased increase VBN cord-104204-pdnkabwj 44 5 blood blood NN cord-104204-pdnkabwj 44 6 pressure pressure NN cord-104204-pdnkabwj 44 7 is be VBZ cord-104204-pdnkabwj 44 8 found find VBN cord-104204-pdnkabwj 44 9 , , , cord-104204-pdnkabwj 44 10 even even RB cord-104204-pdnkabwj 44 11 in in IN cord-104204-pdnkabwj 44 12 the the DT cord-104204-pdnkabwj 44 13 more more RBR cord-104204-pdnkabwj 44 14 advanced advanced JJ cord-104204-pdnkabwj 44 15 phases phase NNS cord-104204-pdnkabwj 44 16 of of IN cord-104204-pdnkabwj 44 17 the the DT cord-104204-pdnkabwj 44 18 disease disease NN cord-104204-pdnkabwj 44 19 ; ; : cord-104204-pdnkabwj 44 20 this this DT cord-104204-pdnkabwj 44 21 was be VBD cord-104204-pdnkabwj 44 22 explained explain VBN cord-104204-pdnkabwj 44 23 by by IN cord-104204-pdnkabwj 44 24 Dammin Dammin NNP cord-104204-pdnkabwj 44 25 ( ( -LRB- cord-104204-pdnkabwj 44 26 12 12 CD cord-104204-pdnkabwj 44 27 ) ) -RRB- cord-104204-pdnkabwj 44 28 as as IN cord-104204-pdnkabwj 44 29 the the DT cord-104204-pdnkabwj 44 30 outcome outcome NN cord-104204-pdnkabwj 44 31 of of IN cord-104204-pdnkabwj 44 32 the the DT cord-104204-pdnkabwj 44 33 early early JJ cord-104204-pdnkabwj 44 34 impairment impairment NN cord-104204-pdnkabwj 44 35 of of IN cord-104204-pdnkabwj 44 36 the the DT cord-104204-pdnkabwj 44 37 juxtaglomerular juxtaglomerular JJ cord-104204-pdnkabwj 44 38 apparatus apparatus NN cord-104204-pdnkabwj 44 39 . . . cord-104204-pdnkabwj 45 1 Anemia anemia NN cord-104204-pdnkabwj 45 2 ( ( -LRB- cord-104204-pdnkabwj 45 3 normocytic normocytic JJ cord-104204-pdnkabwj 45 4 , , , cord-104204-pdnkabwj 45 5 normochromic normochromic JJ cord-104204-pdnkabwj 45 6 , , , cord-104204-pdnkabwj 45 7 or or CC cord-104204-pdnkabwj 45 8 in in IN cord-104204-pdnkabwj 45 9 rare rare JJ cord-104204-pdnkabwj 45 10 cases case NNS cord-104204-pdnkabwj 45 11 , , , cord-104204-pdnkabwj 45 12 hypochromic hypochromic JJ cord-104204-pdnkabwj 45 13 or or CC cord-104204-pdnkabwj 45 14 even even RB cord-104204-pdnkabwj 45 15 aplastic aplastic NN cord-104204-pdnkabwj 45 16 ) ) -RRB- cord-104204-pdnkabwj 45 17 is be VBZ cord-104204-pdnkabwj 45 18 one one CD cord-104204-pdnkabwj 45 19 of of IN cord-104204-pdnkabwj 45 20 the the DT cord-104204-pdnkabwj 45 21 major major JJ cord-104204-pdnkabwj 45 22 symptoms symptom NNS cord-104204-pdnkabwj 45 23 , , , cord-104204-pdnkabwj 45 24 and and CC cord-104204-pdnkabwj 45 25 it -PRON- PRP cord-104204-pdnkabwj 45 26 seems seem VBZ cord-104204-pdnkabwj 45 27 to to TO cord-104204-pdnkabwj 45 28 develop develop VB cord-104204-pdnkabwj 45 29 well well RB cord-104204-pdnkabwj 45 30 before before IN cord-104204-pdnkabwj 45 31 other other JJ cord-104204-pdnkabwj 45 32 signs sign NNS cord-104204-pdnkabwj 45 33 of of IN cord-104204-pdnkabwj 45 34 BEN BEN NNP cord-104204-pdnkabwj 45 35 become become VBP cord-104204-pdnkabwj 45 36 manifest manifest JJ cord-104204-pdnkabwj 45 37 . . . cord-104204-pdnkabwj 46 1 Although although IN cord-104204-pdnkabwj 46 2 in in IN cord-104204-pdnkabwj 46 3 the the DT cord-104204-pdnkabwj 46 4 advanced advanced JJ cord-104204-pdnkabwj 46 5 stages stage NNS cord-104204-pdnkabwj 46 6 of of IN cord-104204-pdnkabwj 46 7 the the DT cord-104204-pdnkabwj 46 8 disease disease NN cord-104204-pdnkabwj 46 9 anemia anemia NN cord-104204-pdnkabwj 46 10 is be VBZ cord-104204-pdnkabwj 46 11 proportional proportional JJ cord-104204-pdnkabwj 46 12 to to IN cord-104204-pdnkabwj 46 13 the the DT cord-104204-pdnkabwj 46 14 degree degree NN cord-104204-pdnkabwj 46 15 of of IN cord-104204-pdnkabwj 46 16 kidney kidney NN cord-104204-pdnkabwj 46 17 insufficiency insufficiency NN cord-104204-pdnkabwj 46 18 and and CC cord-104204-pdnkabwj 46 19 , , , cord-104204-pdnkabwj 46 20 thus thus RB cord-104204-pdnkabwj 46 21 , , , cord-104204-pdnkabwj 46 22 could could MD cord-104204-pdnkabwj 46 23 be be VB cord-104204-pdnkabwj 46 24 attributed attribute VBN cord-104204-pdnkabwj 46 25 to to IN cord-104204-pdnkabwj 46 26 the the DT cord-104204-pdnkabwj 46 27 increased increase VBN cord-104204-pdnkabwj 46 28 blood blood NN cord-104204-pdnkabwj 46 29 urea urea NN cord-104204-pdnkabwj 46 30 level level NN cord-104204-pdnkabwj 46 31 and and CC cord-104204-pdnkabwj 46 32 to to IN cord-104204-pdnkabwj 46 33 the the DT cord-104204-pdnkabwj 46 34 reduction reduction NN cord-104204-pdnkabwj 46 35 of of IN cord-104204-pdnkabwj 46 36 erythropoietin erythropoietin NN cord-104204-pdnkabwj 46 37 synthesis synthesis NN cord-104204-pdnkabwj 46 38 ( ( -LRB- cord-104204-pdnkabwj 46 39 as as IN cord-104204-pdnkabwj 46 40 a a DT cord-104204-pdnkabwj 46 41 result result NN cord-104204-pdnkabwj 46 42 of of IN cord-104204-pdnkabwj 46 43 the the DT cord-104204-pdnkabwj 46 44 destruction destruction NN cord-104204-pdnkabwj 46 45 of of IN cord-104204-pdnkabwj 46 46 the the DT cord-104204-pdnkabwj 46 47 erythropoietin erythropoietin NN cord-104204-pdnkabwj 46 48 - - HYPH cord-104204-pdnkabwj 46 49 secreting secrete VBG cord-104204-pdnkabwj 46 50 peritubular peritubular JJ cord-104204-pdnkabwj 46 51 endothelium endothelium NN cord-104204-pdnkabwj 46 52 of of IN cord-104204-pdnkabwj 46 53 the the DT cord-104204-pdnkabwj 46 54 kidney kidney NN cord-104204-pdnkabwj 46 55 by by IN cord-104204-pdnkabwj 46 56 the the DT cord-104204-pdnkabwj 46 57 etiological etiological JJ cord-104204-pdnkabwj 46 58 agent agent NN cord-104204-pdnkabwj 46 59 ) ) -RRB- cord-104204-pdnkabwj 46 60 , , , cord-104204-pdnkabwj 46 61 it -PRON- PRP cord-104204-pdnkabwj 46 62 usually usually RB cord-104204-pdnkabwj 46 63 appears appear VBZ cord-104204-pdnkabwj 46 64 before before IN cord-104204-pdnkabwj 46 65 significant significant JJ cord-104204-pdnkabwj 46 66 kidney kidney NN cord-104204-pdnkabwj 46 67 damage damage NN cord-104204-pdnkabwj 46 68 takes take VBZ cord-104204-pdnkabwj 46 69 place place NN cord-104204-pdnkabwj 46 70 . . . cord-104204-pdnkabwj 47 1 In in IN cord-104204-pdnkabwj 47 2 this this DT cord-104204-pdnkabwj 47 3 regard regard NN cord-104204-pdnkabwj 47 4 , , , cord-104204-pdnkabwj 47 5 it -PRON- PRP cord-104204-pdnkabwj 47 6 was be VBD cord-104204-pdnkabwj 47 7 presumed presume VBN cord-104204-pdnkabwj 47 8 that that IN cord-104204-pdnkabwj 47 9 the the DT cord-104204-pdnkabwj 47 10 nephrotoxic nephrotoxic NNP cord-104204-pdnkabwj 47 11 factor(s factor(s NNP cord-104204-pdnkabwj 47 12 ) ) -RRB- cord-104204-pdnkabwj 47 13 responsible responsible JJ cord-104204-pdnkabwj 47 14 for for IN cord-104204-pdnkabwj 47 15 BEN BEN NNP cord-104204-pdnkabwj 47 16 could could MD cord-104204-pdnkabwj 47 17 also also RB cord-104204-pdnkabwj 47 18 be be VB cord-104204-pdnkabwj 47 19 hematotoxic hematotoxic NN cord-104204-pdnkabwj 47 20 , , , cord-104204-pdnkabwj 47 21 inducing induce VBG cord-104204-pdnkabwj 47 22 anemia anemia NN cord-104204-pdnkabwj 47 23 and and CC cord-104204-pdnkabwj 47 24 other other JJ cord-104204-pdnkabwj 47 25 possible possible JJ cord-104204-pdnkabwj 47 26 hematological hematological JJ cord-104204-pdnkabwj 47 27 disturbances disturbance NNS cord-104204-pdnkabwj 47 28 ( ( -LRB- cord-104204-pdnkabwj 47 29 4 4 CD cord-104204-pdnkabwj 47 30 , , , cord-104204-pdnkabwj 47 31 13 13 CD cord-104204-pdnkabwj 47 32 ) ) -RRB- cord-104204-pdnkabwj 47 33 . . . cord-104204-pdnkabwj 48 1 Flow flow VB cord-104204-pdnkabwj 48 2 cytometric cytometric JJ cord-104204-pdnkabwj 48 3 investigation investigation NN cord-104204-pdnkabwj 48 4 of of IN cord-104204-pdnkabwj 48 5 BEN BEN NNP cord-104204-pdnkabwj 48 6 patients patient NNS cord-104204-pdnkabwj 48 7 and and CC cord-104204-pdnkabwj 48 8 area area NN cord-104204-pdnkabwj 48 9 control control NN cord-104204-pdnkabwj 48 10 individuals individual NNS cord-104204-pdnkabwj 48 11 ( ( -LRB- cord-104204-pdnkabwj 48 12 people people NNS cord-104204-pdnkabwj 48 13 born bear VBN cord-104204-pdnkabwj 48 14 and and CC cord-104204-pdnkabwj 48 15 living live VBG cord-104204-pdnkabwj 48 16 in in IN cord-104204-pdnkabwj 48 17 the the DT cord-104204-pdnkabwj 48 18 endemic endemic JJ cord-104204-pdnkabwj 48 19 area area NN cord-104204-pdnkabwj 48 20 and and CC cord-104204-pdnkabwj 48 21 clinically clinically RB cord-104204-pdnkabwj 48 22 asymptomatic asymptomatic JJ cord-104204-pdnkabwj 48 23 , , , cord-104204-pdnkabwj 48 24 but but CC cord-104204-pdnkabwj 48 25 having have VBG cord-104204-pdnkabwj 48 26 BEN BEN NNP cord-104204-pdnkabwj 48 27 and and CC cord-104204-pdnkabwj 48 28 a a DT cord-104204-pdnkabwj 48 29 BEN BEN NNP cord-104204-pdnkabwj 48 30 death death NN cord-104204-pdnkabwj 48 31 - - HYPH cord-104204-pdnkabwj 48 32 related relate VBN cord-104204-pdnkabwj 48 33 family family NN cord-104204-pdnkabwj 48 34 history history NN cord-104204-pdnkabwj 48 35 ) ) -RRB- cord-104204-pdnkabwj 48 36 revealed reveal VBN cord-104204-pdnkabwj 48 37 in in IN cord-104204-pdnkabwj 48 38 many many JJ cord-104204-pdnkabwj 48 39 cases case NNS cord-104204-pdnkabwj 48 40 a a DT cord-104204-pdnkabwj 48 41 decreased decrease VBN cord-104204-pdnkabwj 48 42 B b NN cord-104204-pdnkabwj 48 43 - - HYPH cord-104204-pdnkabwj 48 44 cell cell NN cord-104204-pdnkabwj 48 45 count count NN cord-104204-pdnkabwj 48 46 , , , cord-104204-pdnkabwj 48 47 eosinophiia eosinophiia NNP cord-104204-pdnkabwj 48 48 , , , cord-104204-pdnkabwj 48 49 and and CC cord-104204-pdnkabwj 48 50 an an DT cord-104204-pdnkabwj 48 51 increased increase VBN cord-104204-pdnkabwj 48 52 proportion proportion NN cord-104204-pdnkabwj 48 53 of of IN cord-104204-pdnkabwj 48 54 CD3+CD8+CD CD3+CD8+CD NNP cord-104204-pdnkabwj 48 55 16+CD56 16+cd56 CD cord-104204-pdnkabwj 48 56 + + CC cord-104204-pdnkabwj 48 57 cytotoxic cytotoxic JJ cord-104204-pdnkabwj 48 58 lymphocytes lymphocyte NNS cord-104204-pdnkabwj 48 59 ( ( -LRB- cord-104204-pdnkabwj 48 60 14 14 CD cord-104204-pdnkabwj 48 61 , , , cord-104204-pdnkabwj 48 62 15 15 CD cord-104204-pdnkabwj 48 63 ) ) -RRB- cord-104204-pdnkabwj 48 64 . . . cord-104204-pdnkabwj 49 1 Because because IN cord-104204-pdnkabwj 49 2 similar similar JJ cord-104204-pdnkabwj 49 3 modifications modification NNS cord-104204-pdnkabwj 49 4 can can MD cord-104204-pdnkabwj 49 5 be be VB cord-104204-pdnkabwj 49 6 induced induce VBN cord-104204-pdnkabwj 49 7 by by IN cord-104204-pdnkabwj 49 8 certain certain JJ cord-104204-pdnkabwj 49 9 toxic toxic JJ cord-104204-pdnkabwj 49 10 compounds compound NNS cord-104204-pdnkabwj 49 11 [ [ -LRB- cord-104204-pdnkabwj 49 12 halogenated halogenate VBN cord-104204-pdnkabwj 49 13 aromatic aromatic JJ cord-104204-pdnkabwj 49 14 hydrocarbons hydrocarbon NNS cord-104204-pdnkabwj 49 15 , , , cord-104204-pdnkabwj 49 16 polycyclic polycyclic JJ cord-104204-pdnkabwj 49 17 aromatic aromatic JJ cord-104204-pdnkabwj 49 18 hydrocarbons hydrocarbon NNS cord-104204-pdnkabwj 49 19 ( ( -LRB- cord-104204-pdnkabwj 49 20 PAHs pah NNS cord-104204-pdnkabwj 49 21 ) ) -RRB- cord-104204-pdnkabwj 49 22 ] ] -RRB- cord-104204-pdnkabwj 50 1 in in IN cord-104204-pdnkabwj 50 2 experimental experimental JJ cord-104204-pdnkabwj 50 3 animals animal NNS cord-104204-pdnkabwj 50 4 , , , cord-104204-pdnkabwj 50 5 the the DT cord-104204-pdnkabwj 50 6 authors author NNS cord-104204-pdnkabwj 50 7 linked link VBD cord-104204-pdnkabwj 50 8 these these DT cord-104204-pdnkabwj 50 9 alterations alteration NNS cord-104204-pdnkabwj 50 10 to to IN cord-104204-pdnkabwj 50 11 the the DT cord-104204-pdnkabwj 50 12 same same JJ cord-104204-pdnkabwj 50 13 presumed presume VBN cord-104204-pdnkabwj 50 14 toxic toxic JJ cord-104204-pdnkabwj 50 15 agent agent NN cord-104204-pdnkabwj 50 16 that that WDT cord-104204-pdnkabwj 50 17 caused cause VBD cord-104204-pdnkabwj 50 18 the the DT cord-104204-pdnkabwj 50 19 kidney kidney NN cord-104204-pdnkabwj 50 20 alterations alteration NNS cord-104204-pdnkabwj 50 21 . . . cord-104204-pdnkabwj 51 1 The the DT cord-104204-pdnkabwj 51 2 immunoglobulin immunoglobulin NN cord-104204-pdnkabwj 51 3 ( ( -LRB- cord-104204-pdnkabwj 51 4 IgM IgM NNP cord-104204-pdnkabwj 51 5 , , , cord-104204-pdnkabwj 51 6 IgG IgG NNP cord-104204-pdnkabwj 51 7 ) ) -RRB- cord-104204-pdnkabwj 51 8 levels level NNS cord-104204-pdnkabwj 51 9 are be VBP cord-104204-pdnkabwj 51 10 normal normal JJ cord-104204-pdnkabwj 51 11 and and CC cord-104204-pdnkabwj 51 12 no no DT cord-104204-pdnkabwj 51 13 signs sign NNS cord-104204-pdnkabwj 51 14 of of IN cord-104204-pdnkabwj 51 15 humoral humoral JJ cord-104204-pdnkabwj 51 16 or or CC cord-104204-pdnkabwj 51 17 cellular cellular JJ cord-104204-pdnkabwj 51 18 immunodeficiency immunodeficiency NN cord-104204-pdnkabwj 51 19 were be VBD cord-104204-pdnkabwj 51 20 seen see VBN cord-104204-pdnkabwj 51 21 , , , cord-104204-pdnkabwj 51 22 while while IN cord-104204-pdnkabwj 51 23 a a DT cord-104204-pdnkabwj 51 24 decreased decrease VBN cord-104204-pdnkabwj 51 25 phagocytic phagocytic JJ cord-104204-pdnkabwj 51 26 activity activity NN cord-104204-pdnkabwj 51 27 was be VBD cord-104204-pdnkabwj 51 28 observed observe VBN cord-104204-pdnkabwj 51 29 in in IN cord-104204-pdnkabwj 51 30 certain certain JJ cord-104204-pdnkabwj 51 31 cases case NNS cord-104204-pdnkabwj 51 32 ( ( -LRB- cord-104204-pdnkabwj 51 33 S. S. NNP cord-104204-pdnkabwj 51 34 Gotia Gotia NNP cord-104204-pdnkabwj 51 35 , , , cord-104204-pdnkabwj 51 36 personal personal JJ cord-104204-pdnkabwj 51 37 communication communication NN cord-104204-pdnkabwj 51 38 ) ) -RRB- cord-104204-pdnkabwj 51 39 . . . cord-104204-pdnkabwj 52 1 The the DT cord-104204-pdnkabwj 52 2 serum serum NN cord-104204-pdnkabwj 52 3 levels level NNS cord-104204-pdnkabwj 52 4 of of IN cord-104204-pdnkabwj 52 5 inflammatory inflammatory JJ cord-104204-pdnkabwj 52 6 cytokines cytokine NNS cord-104204-pdnkabwj 52 7 [ [ -LRB- cord-104204-pdnkabwj 52 8 interleukin-1 interleukin-1 NN cord-104204-pdnkabwj 52 9 ( ( -LRB- cord-104204-pdnkabwj 52 10 IL-1 IL-1 NNP cord-104204-pdnkabwj 52 11 ) ) -RRB- cord-104204-pdnkabwj 52 12 , , , cord-104204-pdnkabwj 52 13 tumor tumor NN cord-104204-pdnkabwj 52 14 necrosis necrosis NN cord-104204-pdnkabwj 52 15 factor factor NN cord-104204-pdnkabwj 52 16 - - : cord-104204-pdnkabwj 52 17 a a DT cord-104204-pdnkabwj 52 18 ( ( -LRB- cord-104204-pdnkabwj 52 19 TNF TNF NNP cord-104204-pdnkabwj 52 20 - - HYPH cord-104204-pdnkabwj 52 21 a a NNP cord-104204-pdnkabwj 52 22 ) ) -RRB- cord-104204-pdnkabwj 52 23 , , , cord-104204-pdnkabwj 52 24 interleukin-6 interleukin-6 NNP cord-104204-pdnkabwj 52 25 ( ( -LRB- cord-104204-pdnkabwj 52 26 IL-6 IL-6 NNP cord-104204-pdnkabwj 52 27 ) ) -RRB- cord-104204-pdnkabwj 52 28 , , , cord-104204-pdnkabwj 52 29 and and CC cord-104204-pdnkabwj 52 30 interferon interferon NN cord-104204-pdnkabwj 52 31 - - HYPH cord-104204-pdnkabwj 52 32 y y NNP cord-104204-pdnkabwj 52 33 ( ( -LRB- cord-104204-pdnkabwj 52 34 IFN IFN NNP cord-104204-pdnkabwj 52 35 - - HYPH cord-104204-pdnkabwj 52 36 y y NNP cord-104204-pdnkabwj 52 37 ) ) -RRB- cord-104204-pdnkabwj 52 38 are be VBP cord-104204-pdnkabwj 52 39 normal normal JJ cord-104204-pdnkabwj 52 40 in in IN cord-104204-pdnkabwj 52 41 most most JJS cord-104204-pdnkabwj 52 42 of of IN cord-104204-pdnkabwj 52 43 the the DT cord-104204-pdnkabwj 52 44 cases case NNS cord-104204-pdnkabwj 53 1 [ [ -LRB- cord-104204-pdnkabwj 53 2 Drugarin Drugarin NNP cord-104204-pdnkabwj 53 3 et et NNP cord-104204-pdnkabwj 53 4 al al NNP cord-104204-pdnkabwj 53 5 . . NNP cord-104204-pdnkabwj 53 6 , , , cord-104204-pdnkabwj 54 1 Tatu Tatu NNP cord-104204-pdnkabwj 54 2 et et NNP cord-104204-pdnkabwj 54 3 al al NNP cord-104204-pdnkabwj 54 4 . . NNP cord-104204-pdnkabwj 54 5 , , , cord-104204-pdnkabwj 54 6 unpublished unpublished JJ cord-104204-pdnkabwj 54 7 observations observation NNS cord-104204-pdnkabwj 54 8 ) ) -RRB- cord-104204-pdnkabwj 54 9 ; ; : cord-104204-pdnkabwj 54 10 ( ( -LRB- cord-104204-pdnkabwj 54 11 16 16 CD cord-104204-pdnkabwj 54 12 ) ) -RRB- cord-104204-pdnkabwj 54 13 ] ] -RRB- cord-104204-pdnkabwj 54 14 , , , cord-104204-pdnkabwj 54 15 stressing stress VBG cord-104204-pdnkabwj 54 16 again again RB cord-104204-pdnkabwj 54 17 the the DT cord-104204-pdnkabwj 54 18 fact fact NN cord-104204-pdnkabwj 54 19 that that IN cord-104204-pdnkabwj 54 20 BEN BEN NNP cord-104204-pdnkabwj 54 21 is be VBZ cord-104204-pdnkabwj 54 22 not not RB cord-104204-pdnkabwj 54 23 an an DT cord-104204-pdnkabwj 54 24 inflammatory inflammatory JJ cord-104204-pdnkabwj 54 25 kidney kidney NN cord-104204-pdnkabwj 54 26 disease disease NN cord-104204-pdnkabwj 54 27 . . . cord-104204-pdnkabwj 55 1 The the DT cord-104204-pdnkabwj 55 2 serum serum NN cord-104204-pdnkabwj 55 3 levels level NNS cord-104204-pdnkabwj 55 4 of of IN cord-104204-pdnkabwj 55 5 albumin albumin NN cord-104204-pdnkabwj 55 6 , , , cord-104204-pdnkabwj 55 7 C C NNP cord-104204-pdnkabwj 55 8 reactive reactive JJ cord-104204-pdnkabwj 55 9 protein protein NN cord-104204-pdnkabwj 55 10 , , , cord-104204-pdnkabwj 55 11 ceruloplasmin ceruloplasmin NNP cord-104204-pdnkabwj 55 12 , , , cord-104204-pdnkabwj 55 13 fibrinogen fibrinogen NN cord-104204-pdnkabwj 55 14 , , , cord-104204-pdnkabwj 55 15 and and CC cord-104204-pdnkabwj 55 16 a a DT cord-104204-pdnkabwj 55 17 - - HYPH cord-104204-pdnkabwj 55 18 l l NN cord-104204-pdnkabwj 55 19 - - HYPH cord-104204-pdnkabwj 55 20 antitrypsin antitrypsin NN cord-104204-pdnkabwj 55 21 are be VBP cord-104204-pdnkabwj 55 22 normal normal JJ cord-104204-pdnkabwj 55 23 except except IN cord-104204-pdnkabwj 55 24 for for IN cord-104204-pdnkabwj 55 25 the the DT cord-104204-pdnkabwj 55 26 advanced advanced JJ cord-104204-pdnkabwj 55 27 phases phase NNS cord-104204-pdnkabwj 55 28 of of IN cord-104204-pdnkabwj 55 29 the the DT cord-104204-pdnkabwj 55 30 disease disease NN cord-104204-pdnkabwj 55 31 , , , cord-104204-pdnkabwj 55 32 when when WRB cord-104204-pdnkabwj 55 33 their -PRON- PRP$ cord-104204-pdnkabwj 55 34 lower low JJR cord-104204-pdnkabwj 55 35 levels level NNS cord-104204-pdnkabwj 55 36 could could MD cord-104204-pdnkabwj 55 37 be be VB cord-104204-pdnkabwj 55 38 attributed attribute VBN cord-104204-pdnkabwj 55 39 to to IN cord-104204-pdnkabwj 55 40 uremia uremia NN cord-104204-pdnkabwj 55 41 and and CC cord-104204-pdnkabwj 55 42 to to IN cord-104204-pdnkabwj 55 43 the the DT cord-104204-pdnkabwj 55 44 reduced reduce VBN cord-104204-pdnkabwj 55 45 liver liver NN cord-104204-pdnkabwj 55 46 synthesis synthesis NN cord-104204-pdnkabwj 55 47 . . . cord-104204-pdnkabwj 56 1 Morphopathologically Morphopathologically NNP cord-104204-pdnkabwj 56 2 , , , cord-104204-pdnkabwj 56 3 BEN BEN NNP cord-104204-pdnkabwj 56 4 is be VBZ cord-104204-pdnkabwj 56 5 a a DT cord-104204-pdnkabwj 56 6 tubulointerstitial tubulointerstitial JJ cord-104204-pdnkabwj 56 7 nephropathy nephropathy NN cord-104204-pdnkabwj 56 8 with with IN cord-104204-pdnkabwj 56 9 a a DT cord-104204-pdnkabwj 56 10 relatively relatively RB cord-104204-pdnkabwj 56 11 nonspecific nonspecific JJ cord-104204-pdnkabwj 56 12 aspect aspect NN cord-104204-pdnkabwj 56 13 . . . cord-104204-pdnkabwj 57 1 In in IN cord-104204-pdnkabwj 57 2 the the DT cord-104204-pdnkabwj 57 3 advanced advanced JJ cord-104204-pdnkabwj 57 4 stages stage NNS cord-104204-pdnkabwj 57 5 , , , cord-104204-pdnkabwj 57 6 kidneys kidney NNS cord-104204-pdnkabwj 57 7 are be VBP cord-104204-pdnkabwj 57 8 reduced reduce VBN cord-104204-pdnkabwj 57 9 in in IN cord-104204-pdnkabwj 57 10 size size NN cord-104204-pdnkabwj 57 11 symmetrically symmetrically RB cord-104204-pdnkabwj 57 12 and and CC cord-104204-pdnkabwj 57 13 can can MD cord-104204-pdnkabwj 57 14 weigh weigh VB cord-104204-pdnkabwj 57 15 as as RB cord-104204-pdnkabwj 57 16 little little JJ cord-104204-pdnkabwj 57 17 as as IN cord-104204-pdnkabwj 57 18 50 50 CD cord-104204-pdnkabwj 57 19 g g NN cord-104204-pdnkabwj 57 20 or or CC cord-104204-pdnkabwj 57 21 less less JJR cord-104204-pdnkabwj 57 22 . . . cord-104204-pdnkabwj 58 1 Histological histological JJ cord-104204-pdnkabwj 58 2 examination examination NN cord-104204-pdnkabwj 58 3 reveals reveal VBZ cord-104204-pdnkabwj 58 4 pronounced pronounce VBN cord-104204-pdnkabwj 58 5 fibrotic fibrotic JJ cord-104204-pdnkabwj 58 6 changes change NNS cord-104204-pdnkabwj 58 7 of of IN cord-104204-pdnkabwj 58 8 the the DT cord-104204-pdnkabwj 58 9 interstitium interstitium NN cord-104204-pdnkabwj 58 10 without without IN cord-104204-pdnkabwj 58 11 cellular cellular JJ cord-104204-pdnkabwj 58 12 infiltrate infiltrate NN cord-104204-pdnkabwj 58 13 or or CC cord-104204-pdnkabwj 58 14 signs sign NNS cord-104204-pdnkabwj 58 15 of of IN cord-104204-pdnkabwj 58 16 inflammation inflammation NN cord-104204-pdnkabwj 58 17 . . . cord-104204-pdnkabwj 59 1 The the DT cord-104204-pdnkabwj 59 2 initial initial JJ cord-104204-pdnkabwj 59 3 lesion lesion NN cord-104204-pdnkabwj 59 4 seems seem VBZ cord-104204-pdnkabwj 59 5 to to TO cord-104204-pdnkabwj 59 6 be be VB cord-104204-pdnkabwj 59 7 confined confine VBN cord-104204-pdnkabwj 59 8 to to IN cord-104204-pdnkabwj 59 9 the the DT cord-104204-pdnkabwj 59 10 proximal proximal JJ cord-104204-pdnkabwj 59 11 convoluted convoluted JJ cord-104204-pdnkabwj 59 12 tubules tubule NNS cord-104204-pdnkabwj 59 13 , , , cord-104204-pdnkabwj 59 14 leading lead VBG cord-104204-pdnkabwj 59 15 to to IN cord-104204-pdnkabwj 59 16 tubular tubular JJ cord-104204-pdnkabwj 59 17 atrophy atrophy NN cord-104204-pdnkabwj 59 18 and and CC cord-104204-pdnkabwj 59 19 pronounced pronounced JJ cord-104204-pdnkabwj 59 20 basilar basilar JJ cord-104204-pdnkabwj 59 21 membranes membrane NNS cord-104204-pdnkabwj 59 22 . . . cord-104204-pdnkabwj 60 1 In in IN cord-104204-pdnkabwj 60 2 the the DT cord-104204-pdnkabwj 60 3 incipient incipient JJ cord-104204-pdnkabwj 60 4 stages stage NNS cord-104204-pdnkabwj 60 5 of of IN cord-104204-pdnkabwj 60 6 the the DT cord-104204-pdnkabwj 60 7 disease disease NN cord-104204-pdnkabwj 60 8 , , , cord-104204-pdnkabwj 60 9 glomeruli glomerulus NNS cord-104204-pdnkabwj 60 10 do do VBP cord-104204-pdnkabwj 60 11 not not RB cord-104204-pdnkabwj 60 12 seem seem VB cord-104204-pdnkabwj 60 13 to to TO cord-104204-pdnkabwj 60 14 be be VB cord-104204-pdnkabwj 60 15 affected affect VBN cord-104204-pdnkabwj 60 16 , , , cord-104204-pdnkabwj 60 17 although although IN cord-104204-pdnkabwj 60 18 later later RB cord-104204-pdnkabwj 60 19 periglomerular periglomerular JJ cord-104204-pdnkabwj 60 20 fibrosis fibrosis NN cord-104204-pdnkabwj 60 21 and and CC cord-104204-pdnkabwj 60 22 cysts cyst NNS cord-104204-pdnkabwj 60 23 in in IN cord-104204-pdnkabwj 60 24 the the DT cord-104204-pdnkabwj 60 25 cortical cortical JJ cord-104204-pdnkabwj 60 26 areas area NNS cord-104204-pdnkabwj 60 27 can can MD cord-104204-pdnkabwj 60 28 be be VB cord-104204-pdnkabwj 60 29 seen see VBN cord-104204-pdnkabwj 60 30 . . . cord-104204-pdnkabwj 61 1 Atherosclerosis atherosclerosis NN cord-104204-pdnkabwj 61 2 may may MD cord-104204-pdnkabwj 61 3 also also RB cord-104204-pdnkabwj 61 4 occur occur VB cord-104204-pdnkabwj 61 5 in in IN cord-104204-pdnkabwj 61 6 kidney kidney NN cord-104204-pdnkabwj 61 7 vessels vessel NNS cord-104204-pdnkabwj 61 8 ( ( -LRB- cord-104204-pdnkabwj 61 9 17 17 CD cord-104204-pdnkabwj 61 10 ) ) -RRB- cord-104204-pdnkabwj 61 11 . . . cord-104204-pdnkabwj 62 1 A a DT cord-104204-pdnkabwj 62 2 peculiar peculiar JJ cord-104204-pdnkabwj 62 3 feature feature NN cord-104204-pdnkabwj 62 4 of of IN cord-104204-pdnkabwj 62 5 BEN BEN NNP cord-104204-pdnkabwj 62 6 is be VBZ cord-104204-pdnkabwj 62 7 its -PRON- PRP$ cord-104204-pdnkabwj 62 8 frequent frequent JJ cord-104204-pdnkabwj 62 9 association association NN cord-104204-pdnkabwj 62 10 with with IN cord-104204-pdnkabwj 62 11 malignant malignant JJ cord-104204-pdnkabwj 62 12 tumors tumor NNS cord-104204-pdnkabwj 62 13 of of IN cord-104204-pdnkabwj 62 14 the the DT cord-104204-pdnkabwj 62 15 upper upper JJ cord-104204-pdnkabwj 62 16 urinary urinary JJ cord-104204-pdnkabwj 62 17 tract tract NN cord-104204-pdnkabwj 62 18 ( ( -LRB- cord-104204-pdnkabwj 62 19 renal renal JJ cord-104204-pdnkabwj 62 20 pelvis pelvi NNS cord-104204-pdnkabwj 62 21 and and CC cord-104204-pdnkabwj 62 22 ureters ureter NNS cord-104204-pdnkabwj 62 23 ) ) -RRB- cord-104204-pdnkabwj 62 24 . . . cord-104204-pdnkabwj 63 1 These these DT cord-104204-pdnkabwj 63 2 tumors tumor NNS cord-104204-pdnkabwj 63 3 develop develop VBP cord-104204-pdnkabwj 63 4 from from IN cord-104204-pdnkabwj 63 5 the the DT cord-104204-pdnkabwj 63 6 urothelium urothelium NN cord-104204-pdnkabwj 63 7 and and CC cord-104204-pdnkabwj 63 8 usually usually RB cord-104204-pdnkabwj 63 9 have have VBP cord-104204-pdnkabwj 63 10 an an DT cord-104204-pdnkabwj 63 11 aggressive aggressive JJ cord-104204-pdnkabwj 63 12 behavior behavior NN cord-104204-pdnkabwj 63 13 . . . cord-104204-pdnkabwj 64 1 There there EX cord-104204-pdnkabwj 64 2 are be VBP cord-104204-pdnkabwj 64 3 many many JJ cord-104204-pdnkabwj 64 4 unknown unknown JJ cord-104204-pdnkabwj 64 5 aspects aspect NNS cord-104204-pdnkabwj 64 6 concerning concern VBG cord-104204-pdnkabwj 64 7 BEN BEN NNP cord-104204-pdnkabwj 64 8 as as IN cord-104204-pdnkabwj 64 9 a a DT cord-104204-pdnkabwj 64 10 disease disease NN cord-104204-pdnkabwj 64 11 , , , cord-104204-pdnkabwj 64 12 but but CC cord-104204-pdnkabwj 64 13 its -PRON- PRP$ cord-104204-pdnkabwj 64 14 etiology etiology NN cord-104204-pdnkabwj 64 15 is be VBZ cord-104204-pdnkabwj 64 16 the the DT cord-104204-pdnkabwj 64 17 central central JJ cord-104204-pdnkabwj 64 18 topic topic NN cord-104204-pdnkabwj 64 19 of of IN cord-104204-pdnkabwj 64 20 dispute dispute NN cord-104204-pdnkabwj 64 21 . . . cord-104204-pdnkabwj 65 1 Perhaps perhaps RB cord-104204-pdnkabwj 65 2 no no DT cord-104204-pdnkabwj 65 3 other other JJ cord-104204-pdnkabwj 65 4 human human JJ cord-104204-pdnkabwj 65 5 disease disease NN cord-104204-pdnkabwj 65 6 has have VBZ cord-104204-pdnkabwj 65 7 generated generate VBN cord-104204-pdnkabwj 65 8 so so RB cord-104204-pdnkabwj 65 9 many many JJ cord-104204-pdnkabwj 65 10 different different JJ cord-104204-pdnkabwj 65 11 hypotheses hypothesis NNS cord-104204-pdnkabwj 65 12 and and CC cord-104204-pdnkabwj 65 13 ideas idea NNS cord-104204-pdnkabwj 65 14 in in IN cord-104204-pdnkabwj 65 15 an an DT cord-104204-pdnkabwj 65 16 attempt attempt NN cord-104204-pdnkabwj 65 17 to to TO cord-104204-pdnkabwj 65 18 explain explain VB cord-104204-pdnkabwj 65 19 its -PRON- PRP$ cord-104204-pdnkabwj 65 20 causal causal JJ cord-104204-pdnkabwj 65 21 factors factor NNS cord-104204-pdnkabwj 65 22 . . . cord-104204-pdnkabwj 66 1 For for IN cord-104204-pdnkabwj 66 2 BEN BEN NNP cord-104204-pdnkabwj 66 3 , , , cord-104204-pdnkabwj 66 4 which which WDT cord-104204-pdnkabwj 66 5 was be VBD cord-104204-pdnkabwj 66 6 classified classify VBN cord-104204-pdnkabwj 66 7 as as IN cord-104204-pdnkabwj 66 8 a a DT cord-104204-pdnkabwj 66 9 disease disease NN cord-104204-pdnkabwj 66 10 only only RB cord-104204-pdnkabwj 66 11 in in IN cord-104204-pdnkabwj 66 12 the the DT cord-104204-pdnkabwj 66 13 second second JJ cord-104204-pdnkabwj 66 14 half half NN cord-104204-pdnkabwj 66 15 of of IN cord-104204-pdnkabwj 66 16 the the DT cord-104204-pdnkabwj 66 17 century century NN cord-104204-pdnkabwj 66 18 , , , cord-104204-pdnkabwj 66 19 there there EX cord-104204-pdnkabwj 66 20 have have VBP cord-104204-pdnkabwj 66 21 even even RB cord-104204-pdnkabwj 66 22 been be VBN cord-104204-pdnkabwj 66 23 rumors rumor NNS cord-104204-pdnkabwj 66 24 among among IN cord-104204-pdnkabwj 66 25 the the DT cord-104204-pdnkabwj 66 26 villagers villager NNS cord-104204-pdnkabwj 66 27 that that WDT cord-104204-pdnkabwj 66 28 the the DT cord-104204-pdnkabwj 66 29 illness illness NN cord-104204-pdnkabwj 66 30 is be VBZ cord-104204-pdnkabwj 66 31 caused cause VBN cord-104204-pdnkabwj 66 32 by by IN cord-104204-pdnkabwj 66 33 cosmic cosmic JJ cord-104204-pdnkabwj 66 34 and and CC cord-104204-pdnkabwj 66 35 astrological astrological JJ cord-104204-pdnkabwj 66 36 influences influence NNS cord-104204-pdnkabwj 66 37 beyond beyond IN cord-104204-pdnkabwj 66 38 human human JJ cord-104204-pdnkabwj 66 39 control control NN cord-104204-pdnkabwj 66 40 and and CC cord-104204-pdnkabwj 66 41 comprehension comprehension NN cord-104204-pdnkabwj 66 42 . . . cord-104204-pdnkabwj 67 1 To to TO cord-104204-pdnkabwj 67 2 protect protect VB cord-104204-pdnkabwj 67 3 themselves -PRON- PRP cord-104204-pdnkabwj 67 4 against against IN cord-104204-pdnkabwj 67 5 these these DT cord-104204-pdnkabwj 67 6 dreadful dreadful JJ cord-104204-pdnkabwj 67 7 forces force NNS cord-104204-pdnkabwj 67 8 , , , cord-104204-pdnkabwj 67 9 people people NNS cord-104204-pdnkabwj 67 10 in in IN cord-104204-pdnkabwj 67 11 certain certain JJ cord-104204-pdnkabwj 67 12 endemic endemic JJ cord-104204-pdnkabwj 67 13 regions region NNS cord-104204-pdnkabwj 67 14 ( ( -LRB- cord-104204-pdnkabwj 67 15 e.g. e.g. RB cord-104204-pdnkabwj 67 16 , , , cord-104204-pdnkabwj 67 17 from from IN cord-104204-pdnkabwj 67 18 former former JJ cord-104204-pdnkabwj 67 19 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 67 20 , , , cord-104204-pdnkabwj 67 21 Romania Romania NNP cord-104204-pdnkabwj 67 22 , , , cord-104204-pdnkabwj 67 23 and and CC cord-104204-pdnkabwj 67 24 probably probably RB cord-104204-pdnkabwj 67 25 Bulgaria Bulgaria NNP cord-104204-pdnkabwj 67 26 ) ) -RRB- cord-104204-pdnkabwj 67 27 still still RB cord-104204-pdnkabwj 67 28 wear wear VBP cord-104204-pdnkabwj 67 29 amulets amulet NNS cord-104204-pdnkabwj 67 30 or or CC cord-104204-pdnkabwj 67 31 pendants pendant NNS cord-104204-pdnkabwj 67 32 and and CC cord-104204-pdnkabwj 67 33 perform perform VB cord-104204-pdnkabwj 67 34 ritual ritual NN cord-104204-pdnkabwj 67 35 ceremonies ceremony NNS cord-104204-pdnkabwj 67 36 to to TO cord-104204-pdnkabwj 67 37 be be VB cord-104204-pdnkabwj 67 38 spared spare VBN cord-104204-pdnkabwj 67 39 from from IN cord-104204-pdnkabwj 67 40 becoming become VBG cord-104204-pdnkabwj 67 41 sick sick JJ cord-104204-pdnkabwj 67 42 . . . cord-104204-pdnkabwj 68 1 The the DT cord-104204-pdnkabwj 68 2 profusion profusion NN cord-104204-pdnkabwj 68 3 of of IN cord-104204-pdnkabwj 68 4 factors factor NNS cord-104204-pdnkabwj 68 5 considered consider VBN cord-104204-pdnkabwj 68 6 to to TO cord-104204-pdnkabwj 68 7 cause cause VB cord-104204-pdnkabwj 68 8 BEN BEN NNP cord-104204-pdnkabwj 68 9 reflects reflect VBZ cord-104204-pdnkabwj 68 10 , , , cord-104204-pdnkabwj 68 11 at at IN cord-104204-pdnkabwj 68 12 least least JJS cord-104204-pdnkabwj 68 13 in in IN cord-104204-pdnkabwj 68 14 part part NN cord-104204-pdnkabwj 68 15 , , , cord-104204-pdnkabwj 68 16 the the DT cord-104204-pdnkabwj 68 17 limited limited JJ cord-104204-pdnkabwj 68 18 knowledge knowledge NN cord-104204-pdnkabwj 68 19 of of IN cord-104204-pdnkabwj 68 20 the the DT cord-104204-pdnkabwj 68 21 etiology etiology NN cord-104204-pdnkabwj 68 22 of of IN cord-104204-pdnkabwj 68 23 CIN CIN NNP cord-104204-pdnkabwj 68 24 in in IN cord-104204-pdnkabwj 68 25 general general NN cord-104204-pdnkabwj 68 26 . . . cord-104204-pdnkabwj 69 1 In in IN cord-104204-pdnkabwj 69 2 comparison comparison NN cord-104204-pdnkabwj 69 3 with with IN cord-104204-pdnkabwj 69 4 other other JJ cord-104204-pdnkabwj 69 5 forms form NNS cord-104204-pdnkabwj 69 6 of of IN cord-104204-pdnkabwj 69 7 CIN CIN NNP cord-104204-pdnkabwj 69 8 , , , cord-104204-pdnkabwj 69 9 the the DT cord-104204-pdnkabwj 69 10 main main JJ cord-104204-pdnkabwj 69 11 peculiarity peculiarity NN cord-104204-pdnkabwj 69 12 of of IN cord-104204-pdnkabwj 69 13 BEN BEN NNP cord-104204-pdnkabwj 69 14 is be VBZ cord-104204-pdnkabwj 69 15 its -PRON- PRP$ cord-104204-pdnkabwj 69 16 restricted restricted JJ cord-104204-pdnkabwj 69 17 geographical geographical JJ cord-104204-pdnkabwj 69 18 distribution distribution NN cord-104204-pdnkabwj 69 19 , , , cord-104204-pdnkabwj 69 20 which which WDT cord-104204-pdnkabwj 69 21 became become VBD cord-104204-pdnkabwj 69 22 more more RBR cord-104204-pdnkabwj 69 23 conspicuous conspicuous JJ cord-104204-pdnkabwj 69 24 after after IN cord-104204-pdnkabwj 69 25 descriptions description NNS cord-104204-pdnkabwj 69 26 of of IN cord-104204-pdnkabwj 69 27 the the DT cord-104204-pdnkabwj 69 28 nephropathy nephropathy NN cord-104204-pdnkabwj 69 29 from from IN cord-104204-pdnkabwj 69 30 the the DT cord-104204-pdnkabwj 69 31 involved involve VBN cord-104204-pdnkabwj 69 32 countries country NNS cord-104204-pdnkabwj 69 33 became become VBD cord-104204-pdnkabwj 69 34 available available JJ cord-104204-pdnkabwj 69 35 . . . cord-104204-pdnkabwj 70 1 Considering consider VBG cord-104204-pdnkabwj 70 2 only only RB cord-104204-pdnkabwj 70 3 the the DT cord-104204-pdnkabwj 70 4 geography geography NN cord-104204-pdnkabwj 70 5 of of IN cord-104204-pdnkabwj 70 6 the the DT cord-104204-pdnkabwj 70 7 disease disease NN cord-104204-pdnkabwj 70 8 , , , cord-104204-pdnkabwj 70 9 an an DT cord-104204-pdnkabwj 70 10 environmental environmental JJ cord-104204-pdnkabwj 70 11 etiological etiological JJ cord-104204-pdnkabwj 70 12 agent agent NN cord-104204-pdnkabwj 70 13 seems seem VBZ cord-104204-pdnkabwj 70 14 plausible plausible JJ cord-104204-pdnkabwj 70 15 , , , cord-104204-pdnkabwj 70 16 presumably presumably RB cord-104204-pdnkabwj 70 17 acting act VBG cord-104204-pdnkabwj 70 18 on on IN cord-104204-pdnkabwj 70 19 a a DT cord-104204-pdnkabwj 70 20 predisposing predisposing JJ cord-104204-pdnkabwj 70 21 genetic genetic JJ cord-104204-pdnkabwj 70 22 background background NN cord-104204-pdnkabwj 70 23 of of IN cord-104204-pdnkabwj 70 24 the the DT cord-104204-pdnkabwj 70 25 exposed expose VBN cord-104204-pdnkabwj 70 26 population population NN cord-104204-pdnkabwj 70 27 . . . cord-104204-pdnkabwj 71 1 Other other JJ cord-104204-pdnkabwj 71 2 factors factor NNS cord-104204-pdnkabwj 71 3 that that WDT cord-104204-pdnkabwj 71 4 make make VBP cord-104204-pdnkabwj 71 5 BEN BEN NNP cord-104204-pdnkabwj 71 6 etiology etiology NN cord-104204-pdnkabwj 71 7 research research NN cord-104204-pdnkabwj 71 8 difficult difficult JJ cord-104204-pdnkabwj 71 9 indude indude NN cord-104204-pdnkabwj 71 10 poor poor JJ cord-104204-pdnkabwj 71 11 epidemiological epidemiological JJ cord-104204-pdnkabwj 71 12 data datum NNS cord-104204-pdnkabwj 71 13 gathered gather VBD cord-104204-pdnkabwj 71 14 from from IN cord-104204-pdnkabwj 71 15 the the DT cord-104204-pdnkabwj 71 16 endemic endemic JJ cord-104204-pdnkabwj 71 17 region region NN cord-104204-pdnkabwj 71 18 ; ; , cord-104204-pdnkabwj 71 19 confusing confusing JJ cord-104204-pdnkabwj 71 20 and and CC cord-104204-pdnkabwj 71 21 often often RB cord-104204-pdnkabwj 71 22 contradictory contradictory JJ cord-104204-pdnkabwj 71 23 results result NNS cord-104204-pdnkabwj 71 24 due due JJ cord-104204-pdnkabwj 71 25 to to IN cord-104204-pdnkabwj 71 26 the the DT cord-104204-pdnkabwj 71 27 lack lack NN cord-104204-pdnkabwj 71 28 of of IN cord-104204-pdnkabwj 71 29 communication communication NN cord-104204-pdnkabwj 71 30 and and CC cord-104204-pdnkabwj 71 31 cooperation cooperation NN cord-104204-pdnkabwj 71 32 of of IN cord-104204-pdnkabwj 71 33 BEN BEN NNP cord-104204-pdnkabwj 71 34 researchers researcher NNS cord-104204-pdnkabwj 71 35 from from IN cord-104204-pdnkabwj 71 36 the the DT cord-104204-pdnkabwj 71 37 afflicted afflict VBN cord-104204-pdnkabwj 71 38 countries country NNS cord-104204-pdnkabwj 71 39 ; ; : cord-104204-pdnkabwj 71 40 the the DT cord-104204-pdnkabwj 71 41 lack lack NN cord-104204-pdnkabwj 71 42 of of IN cord-104204-pdnkabwj 71 43 standardized standardized JJ cord-104204-pdnkabwj 71 44 investigation investigation NN cord-104204-pdnkabwj 71 45 methods method NNS cord-104204-pdnkabwj 71 46 ; ; : cord-104204-pdnkabwj 71 47 the the DT cord-104204-pdnkabwj 71 48 communist communist JJ cord-104204-pdnkabwj 71 49 mentality mentality NN cord-104204-pdnkabwj 71 50 ( ( -LRB- cord-104204-pdnkabwj 71 51 e.g. e.g. RB cord-104204-pdnkabwj 71 52 , , , cord-104204-pdnkabwj 71 53 the the DT cord-104204-pdnkabwj 71 54 former former JJ cord-104204-pdnkabwj 71 55 communist communist JJ cord-104204-pdnkabwj 71 56 government government NN cord-104204-pdnkabwj 71 57 from from IN cord-104204-pdnkabwj 71 58 Bulgaria Bulgaria NNP cord-104204-pdnkabwj 71 59 relocated relocate VBD cord-104204-pdnkabwj 71 60 whole whole JJ cord-104204-pdnkabwj 71 61 endemic endemic JJ cord-104204-pdnkabwj 71 62 villages village NNS cord-104204-pdnkabwj 71 63 and and CC cord-104204-pdnkabwj 71 64 never never RB cord-104204-pdnkabwj 71 65 recognized recognize VBD cord-104204-pdnkabwj 71 66 the the DT cord-104204-pdnkabwj 71 67 disease disease NN cord-104204-pdnkabwj 71 68 ; ; : cord-104204-pdnkabwj 71 69 thus thus RB cord-104204-pdnkabwj 71 70 , , , cord-104204-pdnkabwj 71 71 important important JJ cord-104204-pdnkabwj 71 72 medical medical JJ cord-104204-pdnkabwj 71 73 data datum NNS cord-104204-pdnkabwj 71 74 was be VBD cord-104204-pdnkabwj 71 75 lost lose VBN cord-104204-pdnkabwj 71 76 ) ) -RRB- cord-104204-pdnkabwj 72 1 ( ( -LRB- cord-104204-pdnkabwj 72 2 5 5 LS cord-104204-pdnkabwj 72 3 ) ) -RRB- cord-104204-pdnkabwj 72 4 ; ; : cord-104204-pdnkabwj 72 5 a a DT cord-104204-pdnkabwj 72 6 shortage shortage NN cord-104204-pdnkabwj 72 7 of of IN cord-104204-pdnkabwj 72 8 funds fund NNS cord-104204-pdnkabwj 72 9 for for IN cord-104204-pdnkabwj 72 10 specialized specialized JJ cord-104204-pdnkabwj 72 11 teams team NNS cord-104204-pdnkabwj 72 12 to to TO cord-104204-pdnkabwj 72 13 thoroughly thoroughly RB cord-104204-pdnkabwj 72 14 investigate investigate VB cord-104204-pdnkabwj 72 15 the the DT cord-104204-pdnkabwj 72 16 endemic endemic JJ cord-104204-pdnkabwj 72 17 regions region NNS cord-104204-pdnkabwj 72 18 ( ( -LRB- cord-104204-pdnkabwj 72 19 18 18 CD cord-104204-pdnkabwj 72 20 ) ) -RRB- cord-104204-pdnkabwj 72 21 ; ; : cord-104204-pdnkabwj 72 22 and and CC cord-104204-pdnkabwj 72 23 social social JJ cord-104204-pdnkabwj 72 24 events event NNS cord-104204-pdnkabwj 72 25 ( ( -LRB- cord-104204-pdnkabwj 72 26 such such JJ cord-104204-pdnkabwj 72 27 as as IN cord-104204-pdnkabwj 72 28 the the DT cord-104204-pdnkabwj 72 29 war war NN cord-104204-pdnkabwj 72 30 in in IN cord-104204-pdnkabwj 72 31 former former JJ cord-104204-pdnkabwj 72 32 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 72 33 , , , cord-104204-pdnkabwj 72 34 which which WDT cord-104204-pdnkabwj 72 35 in in IN cord-104204-pdnkabwj 72 36 1993 1993 CD cord-104204-pdnkabwj 72 37 cut cut VBD cord-104204-pdnkabwj 72 38 a a DT cord-104204-pdnkabwj 72 39 fruitful fruitful JJ cord-104204-pdnkabwj 72 40 line line NN cord-104204-pdnkabwj 72 41 of of IN cord-104204-pdnkabwj 72 42 research research NN cord-104204-pdnkabwj 72 43 related relate VBN cord-104204-pdnkabwj 72 44 to to IN cord-104204-pdnkabwj 72 45 the the DT cord-104204-pdnkabwj 72 46 role role NN cord-104204-pdnkabwj 72 47 that that IN cord-104204-pdnkabwj 72 48 low low JJ cord-104204-pdnkabwj 72 49 - - HYPH cord-104204-pdnkabwj 72 50 rank rank NN cord-104204-pdnkabwj 72 51 coals coal NNS cord-104204-pdnkabwj 72 52 may may MD cord-104204-pdnkabwj 72 53 play play VB cord-104204-pdnkabwj 72 54 in in IN cord-104204-pdnkabwj 72 55 BEN BEN NNP cord-104204-pdnkabwj 72 56 ) ) -RRB- cord-104204-pdnkabwj 72 57 . . . cord-104204-pdnkabwj 73 1 Despite despite IN cord-104204-pdnkabwj 73 2 these these DT cord-104204-pdnkabwj 73 3 difficulties difficulty NNS cord-104204-pdnkabwj 73 4 , , , cord-104204-pdnkabwj 73 5 major major JJ cord-104204-pdnkabwj 73 6 research research NN cord-104204-pdnkabwj 73 7 efforts effort NNS cord-104204-pdnkabwj 73 8 have have VBP cord-104204-pdnkabwj 73 9 been be VBN cord-104204-pdnkabwj 73 10 made make VBN cord-104204-pdnkabwj 73 11 over over IN cord-104204-pdnkabwj 73 12 several several JJ cord-104204-pdnkabwj 73 13 decades decade NNS cord-104204-pdnkabwj 73 14 in in IN cord-104204-pdnkabwj 73 15 an an DT cord-104204-pdnkabwj 73 16 attempt attempt NN cord-104204-pdnkabwj 73 17 to to TO cord-104204-pdnkabwj 73 18 understand understand VB cord-104204-pdnkabwj 73 19 the the DT cord-104204-pdnkabwj 73 20 causes cause NNS cord-104204-pdnkabwj 73 21 of of IN cord-104204-pdnkabwj 73 22 this this DT cord-104204-pdnkabwj 73 23 still still RB cord-104204-pdnkabwj 73 24 confusing confusing JJ cord-104204-pdnkabwj 73 25 disease disease NN cord-104204-pdnkabwj 73 26 . . . cord-104204-pdnkabwj 74 1 BEN BEN NNP cord-104204-pdnkabwj 74 2 is be VBZ cord-104204-pdnkabwj 74 3 a a DT cord-104204-pdnkabwj 74 4 complex complex JJ cord-104204-pdnkabwj 74 5 medical medical JJ cord-104204-pdnkabwj 74 6 condition condition NN cord-104204-pdnkabwj 74 7 , , , cord-104204-pdnkabwj 74 8 and and CC cord-104204-pdnkabwj 74 9 its -PRON- PRP$ cord-104204-pdnkabwj 74 10 apparent apparent JJ cord-104204-pdnkabwj 74 11 multifactorial multifactorial JJ cord-104204-pdnkabwj 74 12 etiology etiology NN cord-104204-pdnkabwj 74 13 makes make VBZ cord-104204-pdnkabwj 74 14 it -PRON- PRP cord-104204-pdnkabwj 74 15 a a DT cord-104204-pdnkabwj 74 16 challenging challenging JJ cord-104204-pdnkabwj 74 17 research research NN cord-104204-pdnkabwj 74 18 topic topic NN cord-104204-pdnkabwj 74 19 . . . cord-104204-pdnkabwj 75 1 Because because IN cord-104204-pdnkabwj 75 2 the the DT cord-104204-pdnkabwj 75 3 symptoms symptom NNS cord-104204-pdnkabwj 75 4 and and CC cord-104204-pdnkabwj 75 5 pathology pathology NN cord-104204-pdnkabwj 75 6 of of IN cord-104204-pdnkabwj 75 7 BEN BEN NNP cord-104204-pdnkabwj 75 8 in in IN cord-104204-pdnkabwj 75 9 all all PDT cord-104204-pdnkabwj 75 10 the the DT cord-104204-pdnkabwj 75 11 endemic endemic JJ cord-104204-pdnkabwj 75 12 zones zone NNS cord-104204-pdnkabwj 75 13 are be VBP cord-104204-pdnkabwj 75 14 the the DT cord-104204-pdnkabwj 75 15 same same JJ cord-104204-pdnkabwj 75 16 regardless regardless RB cord-104204-pdnkabwj 75 17 of of IN cord-104204-pdnkabwj 75 18 the the DT cord-104204-pdnkabwj 75 19 country country NN cord-104204-pdnkabwj 75 20 where where WRB cord-104204-pdnkabwj 75 21 it -PRON- PRP cord-104204-pdnkabwj 75 22 occurs occur VBZ cord-104204-pdnkabwj 75 23 , , , cord-104204-pdnkabwj 75 24 there there EX cord-104204-pdnkabwj 75 25 is be VBZ cord-104204-pdnkabwj 75 26 probably probably RB cord-104204-pdnkabwj 75 27 a a DT cord-104204-pdnkabwj 75 28 common common JJ cord-104204-pdnkabwj 75 29 etiological etiological JJ cord-104204-pdnkabwj 75 30 factor(s factor(s NNP cord-104204-pdnkabwj 75 31 ) ) -RRB- cord-104204-pdnkabwj 75 32 for for IN cord-104204-pdnkabwj 75 33 the the DT cord-104204-pdnkabwj 75 34 disease disease NN cord-104204-pdnkabwj 75 35 . . . cord-104204-pdnkabwj 76 1 One one CD cord-104204-pdnkabwj 76 2 of of IN cord-104204-pdnkabwj 76 3 the the DT cord-104204-pdnkabwj 76 4 drawbacks drawback NNS cord-104204-pdnkabwj 76 5 of of IN cord-104204-pdnkabwj 76 6 many many JJ cord-104204-pdnkabwj 76 7 of of IN cord-104204-pdnkabwj 76 8 the the DT cord-104204-pdnkabwj 76 9 investigations investigation NNS cord-104204-pdnkabwj 76 10 of of IN cord-104204-pdnkabwj 76 11 BEN BEN NNP cord-104204-pdnkabwj 76 12 is be VBZ cord-104204-pdnkabwj 76 13 that that IN cord-104204-pdnkabwj 76 14 studies study NNS cord-104204-pdnkabwj 76 15 performed perform VBN cord-104204-pdnkabwj 76 16 in in IN cord-104204-pdnkabwj 76 17 one one CD cord-104204-pdnkabwj 76 18 of of IN cord-104204-pdnkabwj 76 19 the the DT cord-104204-pdnkabwj 76 20 three three CD cord-104204-pdnkabwj 76 21 countries country NNS cord-104204-pdnkabwj 76 22 were be VBD cord-104204-pdnkabwj 76 23 not not RB cord-104204-pdnkabwj 76 24 reproduced reproduce VBN cord-104204-pdnkabwj 76 25 by by IN cord-104204-pdnkabwj 76 26 similar similar JJ cord-104204-pdnkabwj 76 27 studies study NNS cord-104204-pdnkabwj 76 28 made make VBN cord-104204-pdnkabwj 76 29 in in IN cord-104204-pdnkabwj 76 30 the the DT cord-104204-pdnkabwj 76 31 other other JJ cord-104204-pdnkabwj 76 32 two two CD cord-104204-pdnkabwj 76 33 countries country NNS cord-104204-pdnkabwj 76 34 , , , cord-104204-pdnkabwj 76 35 posing pose VBG cord-104204-pdnkabwj 76 36 questions question NNS cord-104204-pdnkabwj 76 37 about about IN cord-104204-pdnkabwj 76 38 their -PRON- PRP$ cord-104204-pdnkabwj 76 39 reliability reliability NN cord-104204-pdnkabwj 76 40 . . . cord-104204-pdnkabwj 77 1 For for IN cord-104204-pdnkabwj 77 2 instance instance NN cord-104204-pdnkabwj 77 3 , , , cord-104204-pdnkabwj 77 4 the the DT cord-104204-pdnkabwj 77 5 proposal proposal NN cord-104204-pdnkabwj 77 6 of of IN cord-104204-pdnkabwj 77 7 a a DT cord-104204-pdnkabwj 77 8 viral viral JJ cord-104204-pdnkabwj 77 9 etiology etiology NN cord-104204-pdnkabwj 77 10 of of IN cord-104204-pdnkabwj 77 11 the the DT cord-104204-pdnkabwj 77 12 disease disease NN cord-104204-pdnkabwj 77 13 was be VBD cord-104204-pdnkabwj 77 14 first first RB cord-104204-pdnkabwj 77 15 advanced advance VBN cord-104204-pdnkabwj 77 16 by by IN cord-104204-pdnkabwj 77 17 Georgescu Georgescu NNP cord-104204-pdnkabwj 77 18 in in IN cord-104204-pdnkabwj 77 19 Romania Romania NNP cord-104204-pdnkabwj 77 20 ( ( -LRB- cord-104204-pdnkabwj 77 21 19 19 CD cord-104204-pdnkabwj 77 22 ) ) -RRB- cord-104204-pdnkabwj 77 23 and and CC cord-104204-pdnkabwj 77 24 Apostolov Apostolov NNP cord-104204-pdnkabwj 77 25 in in IN cord-104204-pdnkabwj 77 26 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 77 27 ( ( -LRB- cord-104204-pdnkabwj 77 28 20 20 CD cord-104204-pdnkabwj 77 29 ) ) -RRB- cord-104204-pdnkabwj 77 30 , , , cord-104204-pdnkabwj 77 31 but but CC cord-104204-pdnkabwj 77 32 was be VBD cord-104204-pdnkabwj 77 33 not not RB cord-104204-pdnkabwj 77 34 confirmed confirm VBN cord-104204-pdnkabwj 77 35 by by IN cord-104204-pdnkabwj 77 36 Bulgarian bulgarian JJ cord-104204-pdnkabwj 77 37 studies study NNS cord-104204-pdnkabwj 77 38 . . . cord-104204-pdnkabwj 78 1 Similarly similarly RB cord-104204-pdnkabwj 78 2 , , , cord-104204-pdnkabwj 78 3 in in IN cord-104204-pdnkabwj 78 4 cytogenetic cytogenetic JJ cord-104204-pdnkabwj 78 5 studies study NNS cord-104204-pdnkabwj 78 6 , , , cord-104204-pdnkabwj 78 7 Bulgarian bulgarian JJ cord-104204-pdnkabwj 78 8 groups group NNS cord-104204-pdnkabwj 78 9 reported report VBD cord-104204-pdnkabwj 78 10 the the DT cord-104204-pdnkabwj 78 11 presence presence NN cord-104204-pdnkabwj 78 12 of of IN cord-104204-pdnkabwj 78 13 a a DT cord-104204-pdnkabwj 78 14 chromosomal chromosomal JJ cord-104204-pdnkabwj 78 15 marker marker NN cord-104204-pdnkabwj 78 16 ( ( -LRB- cord-104204-pdnkabwj 78 17 3q25 3q25 CD cord-104204-pdnkabwj 78 18 ) ) -RRB- cord-104204-pdnkabwj 78 19 in in IN cord-104204-pdnkabwj 78 20 BEN BEN NNP cord-104204-pdnkabwj 78 21 ( ( -LRB- cord-104204-pdnkabwj 78 22 21 21 CD cord-104204-pdnkabwj 78 23 , , , cord-104204-pdnkabwj 78 24 22 22 CD cord-104204-pdnkabwj 78 25 ) ) -RRB- cord-104204-pdnkabwj 78 26 , , , cord-104204-pdnkabwj 78 27 but but CC cord-104204-pdnkabwj 78 28 this this DT cord-104204-pdnkabwj 78 29 has have VBZ cord-104204-pdnkabwj 78 30 not not RB cord-104204-pdnkabwj 78 31 been be VBN cord-104204-pdnkabwj 78 32 demonstrated demonstrate VBN cord-104204-pdnkabwj 78 33 so so RB cord-104204-pdnkabwj 78 34 far far RB cord-104204-pdnkabwj 78 35 in in IN cord-104204-pdnkabwj 78 36 Romania Romania NNP cord-104204-pdnkabwj 78 37 or or CC cord-104204-pdnkabwj 78 38 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 78 39 . . . cord-104204-pdnkabwj 79 1 Other other JJ cord-104204-pdnkabwj 79 2 factors factor NNS cord-104204-pdnkabwj 79 3 inconsistently inconsistently RB cord-104204-pdnkabwj 79 4 incriminated incriminate VBN cord-104204-pdnkabwj 79 5 in in IN cord-104204-pdnkabwj 79 6 the the DT cord-104204-pdnkabwj 79 7 etiopathogeny etiopathogeny NN cord-104204-pdnkabwj 79 8 of of IN cord-104204-pdnkabwj 79 9 BEN BEN NNP cord-104204-pdnkabwj 79 10 include include VBP cord-104204-pdnkabwj 79 11 heavy heavy JJ cord-104204-pdnkabwj 79 12 metals metal NNS cord-104204-pdnkabwj 79 13 claimed claim VBD cord-104204-pdnkabwj 79 14 to to TO cord-104204-pdnkabwj 79 15 be be VB cord-104204-pdnkabwj 79 16 present present JJ cord-104204-pdnkabwj 79 17 at at IN cord-104204-pdnkabwj 79 18 higher high JJR cord-104204-pdnkabwj 79 19 ( ( -LRB- cord-104204-pdnkabwj 79 20 lead lead NN cord-104204-pdnkabwj 79 21 , , , cord-104204-pdnkabwj 79 22 cadmium cadmium NN cord-104204-pdnkabwj 79 23 , , , cord-104204-pdnkabwj 79 24 chromium chromium NN cord-104204-pdnkabwj 79 25 ) ) -RRB- cord-104204-pdnkabwj 79 26 ( ( -LRB- cord-104204-pdnkabwj 79 27 23 23 CD cord-104204-pdnkabwj 79 28 ) ) -RRB- cord-104204-pdnkabwj 79 29 or or CC cord-104204-pdnkabwj 79 30 lower low JJR cord-104204-pdnkabwj 79 31 ( ( -LRB- cord-104204-pdnkabwj 79 32 manganese manganese NN cord-104204-pdnkabwj 79 33 , , , cord-104204-pdnkabwj 79 34 cobalt cobalt NN cord-104204-pdnkabwj 79 35 ) ) -RRB- cord-104204-pdnkabwj 79 36 than than IN cord-104204-pdnkabwj 79 37 normal normal JJ cord-104204-pdnkabwj 79 38 concentrations concentration NNS cord-104204-pdnkabwj 79 39 in in IN cord-104204-pdnkabwj 79 40 water water NN cord-104204-pdnkabwj 79 41 or or CC cord-104204-pdnkabwj 79 42 foodstuffs foodstuff NNS cord-104204-pdnkabwj 79 43 from from IN cord-104204-pdnkabwj 79 44 endemic endemic JJ cord-104204-pdnkabwj 79 45 areas area NNS cord-104204-pdnkabwj 79 46 ; ; : cord-104204-pdnkabwj 79 47 selenium selenium NN cord-104204-pdnkabwj 79 48 deficiency deficiency NN cord-104204-pdnkabwj 79 49 ( ( -LRB- cord-104204-pdnkabwj 79 50 24 24 CD cord-104204-pdnkabwj 79 51 , , , cord-104204-pdnkabwj 79 52 25 25 CD cord-104204-pdnkabwj 79 53 ) ) -RRB- cord-104204-pdnkabwj 79 54 ; ; : cord-104204-pdnkabwj 79 55 X x NN cord-104204-pdnkabwj 79 56 ray ray NN cord-104204-pdnkabwj 79 57 - - HYPH cord-104204-pdnkabwj 79 58 emitting emit VBG cord-104204-pdnkabwj 79 59 compounds compound NNS cord-104204-pdnkabwj 79 60 ; ; : cord-104204-pdnkabwj 79 61 and and CC cord-104204-pdnkabwj 79 62 industrial industrial JJ cord-104204-pdnkabwj 79 63 pollution pollution NN cord-104204-pdnkabwj 79 64 . . . cord-104204-pdnkabwj 80 1 Other other JJ cord-104204-pdnkabwj 80 2 studies study NNS cord-104204-pdnkabwj 80 3 incriminate incriminate VBP cord-104204-pdnkabwj 80 4 low low JJ cord-104204-pdnkabwj 80 5 molecular molecular JJ cord-104204-pdnkabwj 80 6 weight weight NN cord-104204-pdnkabwj 80 7 protein protein NN cord-104204-pdnkabwj 80 8 ( ( -LRB- cord-104204-pdnkabwj 80 9 LMWP LMWP NNP cord-104204-pdnkabwj 80 10 ) ) -RRB- cord-104204-pdnkabwj 80 11 excretion excretion NN cord-104204-pdnkabwj 80 12 in in IN cord-104204-pdnkabwj 80 13 patients patient NNS cord-104204-pdnkabwj 80 14 with with IN cord-104204-pdnkabwj 80 15 BEN BEN NNP cord-104204-pdnkabwj 80 16 as as IN cord-104204-pdnkabwj 80 17 a a DT cord-104204-pdnkabwj 80 18 factor factor NN cord-104204-pdnkabwj 80 19 in in IN cord-104204-pdnkabwj 80 20 disease disease NN cord-104204-pdnkabwj 80 21 pathogeny pathogeny NNP cord-104204-pdnkabwj 80 22 ( ( -LRB- cord-104204-pdnkabwj 80 23 26 26 CD cord-104204-pdnkabwj 80 24 ) ) -RRB- cord-104204-pdnkabwj 80 25 . . . cord-104204-pdnkabwj 81 1 Microproteinuria Microproteinuria NNP cord-104204-pdnkabwj 81 2 with with IN cord-104204-pdnkabwj 81 3 3 3 CD cord-104204-pdnkabwj 81 4 - - SYM cord-104204-pdnkabwj 81 5 2 2 CD cord-104204-pdnkabwj 81 6 microglobulin microglobulin NN cord-104204-pdnkabwj 81 7 has have VBZ cord-104204-pdnkabwj 81 8 been be VBN cord-104204-pdnkabwj 81 9 found find VBN cord-104204-pdnkabwj 81 10 in in IN cord-104204-pdnkabwj 81 11 many many JJ cord-104204-pdnkabwj 81 12 BEN BEN NNP cord-104204-pdnkabwj 81 13 patients patient NNS cord-104204-pdnkabwj 81 14 and and CC cord-104204-pdnkabwj 81 15 area area NN cord-104204-pdnkabwj 81 16 controls control NNS cord-104204-pdnkabwj 81 17 . . . cord-104204-pdnkabwj 82 1 Although although IN cord-104204-pdnkabwj 82 2 these these DT cord-104204-pdnkabwj 82 3 proteins protein NNS cord-104204-pdnkabwj 82 4 are be VBP cord-104204-pdnkabwj 82 5 suspected suspect VBN cord-104204-pdnkabwj 82 6 to to TO cord-104204-pdnkabwj 82 7 be be VB cord-104204-pdnkabwj 82 8 involved involve VBN cord-104204-pdnkabwj 82 9 in in IN cord-104204-pdnkabwj 82 10 renal renal JJ cord-104204-pdnkabwj 82 11 diseases disease NNS cord-104204-pdnkabwj 82 12 in in IN cord-104204-pdnkabwj 82 13 humans human NNS cord-104204-pdnkabwj 82 14 and and CC cord-104204-pdnkabwj 82 15 experimental experimental JJ cord-104204-pdnkabwj 82 16 animals animal NNS cord-104204-pdnkabwj 82 17 , , , cord-104204-pdnkabwj 82 18 they -PRON- PRP cord-104204-pdnkabwj 82 19 do do VBP cord-104204-pdnkabwj 82 20 not not RB cord-104204-pdnkabwj 82 21 explain explain VB cord-104204-pdnkabwj 82 22 the the DT cord-104204-pdnkabwj 82 23 geographical geographical JJ cord-104204-pdnkabwj 82 24 restriction restriction NN cord-104204-pdnkabwj 82 25 of of IN cord-104204-pdnkabwj 82 26 BEN BEN NNP cord-104204-pdnkabwj 82 27 . . . cord-104204-pdnkabwj 83 1 In in IN cord-104204-pdnkabwj 83 2 this this DT cord-104204-pdnkabwj 83 3 regard regard NN cord-104204-pdnkabwj 83 4 , , , cord-104204-pdnkabwj 83 5 LMWP LMWP NNP cord-104204-pdnkabwj 83 6 involvement involvement NN cord-104204-pdnkabwj 83 7 is be VBZ cord-104204-pdnkabwj 83 8 probably probably RB cord-104204-pdnkabwj 83 9 secondary secondary JJ cord-104204-pdnkabwj 83 10 , , , cord-104204-pdnkabwj 83 11 after after IN cord-104204-pdnkabwj 83 12 the the DT cord-104204-pdnkabwj 83 13 etiopathogenic etiopathogenic NNP cord-104204-pdnkabwj 83 14 agent agent NN cord-104204-pdnkabwj 83 15 has have VBZ cord-104204-pdnkabwj 83 16 triggered trigger VBN cord-104204-pdnkabwj 83 17 the the DT cord-104204-pdnkabwj 83 18 kidney kidney NN cord-104204-pdnkabwj 83 19 damage damage NN cord-104204-pdnkabwj 83 20 . . . cord-104204-pdnkabwj 84 1 Immunologic immunologic JJ cord-104204-pdnkabwj 84 2 and and CC cord-104204-pdnkabwj 84 3 hematologic hematologic JJ cord-104204-pdnkabwj 84 4 alterations alteration NNS cord-104204-pdnkabwj 84 5 ( ( -LRB- cord-104204-pdnkabwj 84 6 thought think VBD cord-104204-pdnkabwj 84 7 not not RB cord-104204-pdnkabwj 84 8 to to TO cord-104204-pdnkabwj 84 9 be be VB cord-104204-pdnkabwj 84 10 of of IN cord-104204-pdnkabwj 84 11 primary primary JJ cord-104204-pdnkabwj 84 12 role role NN cord-104204-pdnkabwj 84 13 in in IN cord-104204-pdnkabwj 84 14 BEN BEN NNP cord-104204-pdnkabwj 84 15 etiopathogenesis etiopathogenesis NNP cord-104204-pdnkabwj 84 16 ) ) -RRB- cord-104204-pdnkabwj 84 17 may may MD cord-104204-pdnkabwj 84 18 also also RB cord-104204-pdnkabwj 84 19 influence influence VB cord-104204-pdnkabwj 84 20 the the DT cord-104204-pdnkabwj 84 21 evolution evolution NN cord-104204-pdnkabwj 84 22 and and CC cord-104204-pdnkabwj 84 23 outcome outcome NN cord-104204-pdnkabwj 84 24 of of IN cord-104204-pdnkabwj 84 25 the the DT cord-104204-pdnkabwj 84 26 ongoing ongoing JJ cord-104204-pdnkabwj 84 27 ( ( -LRB- cord-104204-pdnkabwj 84 28 established established JJ cord-104204-pdnkabwj 84 29 ) ) -RRB- cord-104204-pdnkabwj 84 30 disease disease NN cord-104204-pdnkabwj 84 31 . . . cord-104204-pdnkabwj 85 1 Anemia anemia NN cord-104204-pdnkabwj 85 2 and and CC cord-104204-pdnkabwj 85 3 the the DT cord-104204-pdnkabwj 85 4 phenotypic phenotypic JJ cord-104204-pdnkabwj 85 5 changes change NNS cord-104204-pdnkabwj 85 6 in in IN cord-104204-pdnkabwj 85 7 lymphocyte lymphocyte NN cord-104204-pdnkabwj 85 8 subpopulations subpopulation NNS cord-104204-pdnkabwj 85 9 ( ( -LRB- cord-104204-pdnkabwj 85 10 e.g. e.g. RB cord-104204-pdnkabwj 85 11 , , , cord-104204-pdnkabwj 85 12 the the DT cord-104204-pdnkabwj 85 13 increase increase NN cord-104204-pdnkabwj 85 14 of of IN cord-104204-pdnkabwj 85 15 a a DT cord-104204-pdnkabwj 85 16 cytotoxic cytotoxic JJ cord-104204-pdnkabwj 85 17 CD8 CD8 NNP cord-104204-pdnkabwj 85 18 + + CC cord-104204-pdnkabwj 85 19 T t NN cord-104204-pdnkabwj 85 20 - - HYPH cord-104204-pdnkabwj 85 21 cell cell NN cord-104204-pdnkabwj 85 22 subset subset NN cord-104204-pdnkabwj 85 23 and and CC cord-104204-pdnkabwj 85 24 a a DT cord-104204-pdnkabwj 85 25 decrease decrease NN cord-104204-pdnkabwj 85 26 in in IN cord-104204-pdnkabwj 85 27 the the DT cord-104204-pdnkabwj 85 28 B b NN cord-104204-pdnkabwj 85 29 lymphocyte lymphocyte NN cord-104204-pdnkabwj 85 30 subpopulation subpopulation NN cord-104204-pdnkabwj 85 31 ) ) -RRB- cord-104204-pdnkabwj 85 32 are be VBP cord-104204-pdnkabwj 85 33 considered consider VBN cord-104204-pdnkabwj 85 34 to to TO cord-104204-pdnkabwj 85 35 be be VB cord-104204-pdnkabwj 85 36 consequential consequential JJ cord-104204-pdnkabwj 85 37 to to IN cord-104204-pdnkabwj 85 38 the the DT cord-104204-pdnkabwj 85 39 action action NN cord-104204-pdnkabwj 85 40 of of IN cord-104204-pdnkabwj 85 41 the the DT cord-104204-pdnkabwj 85 42 same same JJ cord-104204-pdnkabwj 85 43 agent(s agent(s NNP cord-104204-pdnkabwj 85 44 ) ) -RRB- cord-104204-pdnkabwj 85 45 inducing induce VBG cord-104204-pdnkabwj 85 46 kidney kidney NN cord-104204-pdnkabwj 85 47 pathology pathology NN cord-104204-pdnkabwj 85 48 ( ( -LRB- cord-104204-pdnkabwj 85 49 14 14 CD cord-104204-pdnkabwj 85 50 , , , cord-104204-pdnkabwj 85 51 15 15 CD cord-104204-pdnkabwj 85 52 ) ) -RRB- cord-104204-pdnkabwj 85 53 rather rather RB cord-104204-pdnkabwj 85 54 than than IN cord-104204-pdnkabwj 85 55 to to IN cord-104204-pdnkabwj 85 56 the the DT cord-104204-pdnkabwj 85 57 nitrogen nitrogen NN cord-104204-pdnkabwj 85 58 retention retention NN cord-104204-pdnkabwj 85 59 and and CC cord-104204-pdnkabwj 85 60 uremia uremia NN cord-104204-pdnkabwj 85 61 . . . cord-104204-pdnkabwj 86 1 It -PRON- PRP cord-104204-pdnkabwj 86 2 is be VBZ cord-104204-pdnkabwj 86 3 likely likely JJ cord-104204-pdnkabwj 86 4 that that IN cord-104204-pdnkabwj 86 5 such such JJ cord-104204-pdnkabwj 86 6 modifications modification NNS cord-104204-pdnkabwj 86 7 , , , cord-104204-pdnkabwj 86 8 although although IN cord-104204-pdnkabwj 86 9 not not RB cord-104204-pdnkabwj 86 10 marked mark VBN cord-104204-pdnkabwj 86 11 , , , cord-104204-pdnkabwj 86 12 could could MD cord-104204-pdnkabwj 86 13 result result VB cord-104204-pdnkabwj 86 14 in in IN cord-104204-pdnkabwj 86 15 an an DT cord-104204-pdnkabwj 86 16 impaired impaired JJ cord-104204-pdnkabwj 86 17 antiinfectious antiinfectious JJ cord-104204-pdnkabwj 86 18 and and CC cord-104204-pdnkabwj 86 19 antitumoral antitumoral NNP cord-104204-pdnkabwj 86 20 defense defense NN cord-104204-pdnkabwj 86 21 , , , cord-104204-pdnkabwj 86 22 mainly mainly RB cord-104204-pdnkabwj 86 23 in in IN cord-104204-pdnkabwj 86 24 the the DT cord-104204-pdnkabwj 86 25 advanced advanced JJ cord-104204-pdnkabwj 86 26 stages stage NNS cord-104204-pdnkabwj 86 27 of of IN cord-104204-pdnkabwj 86 28 BEN BEN NNP cord-104204-pdnkabwj 86 29 when when WRB cord-104204-pdnkabwj 86 30 the the DT cord-104204-pdnkabwj 86 31 risk risk NN cord-104204-pdnkabwj 86 32 to to TO cord-104204-pdnkabwj 86 33 develop develop VB cord-104204-pdnkabwj 86 34 UTTs utt NNS cord-104204-pdnkabwj 86 35 is be VBZ cord-104204-pdnkabwj 86 36 highest high JJS cord-104204-pdnkabwj 86 37 . . . cord-104204-pdnkabwj 87 1 Another another DT cord-104204-pdnkabwj 87 2 possible possible JJ cord-104204-pdnkabwj 87 3 cofactor cofactor NN cord-104204-pdnkabwj 87 4 or or CC cord-104204-pdnkabwj 87 5 risk risk NN cord-104204-pdnkabwj 87 6 factor factor NN cord-104204-pdnkabwj 87 7 in in IN cord-104204-pdnkabwj 87 8 BEN BEN NNP cord-104204-pdnkabwj 87 9 and and CC cord-104204-pdnkabwj 87 10 UTT UTT NNP cord-104204-pdnkabwj 87 11 is be VBZ cord-104204-pdnkabwj 87 12 selenium selenium NN cord-104204-pdnkabwj 87 13 deficiency deficiency NN cord-104204-pdnkabwj 87 14 , , , cord-104204-pdnkabwj 87 15 which which WDT cord-104204-pdnkabwj 87 16 is be VBZ cord-104204-pdnkabwj 87 17 well well RB cord-104204-pdnkabwj 87 18 documented document VBN cord-104204-pdnkabwj 87 19 in in IN cord-104204-pdnkabwj 87 20 rocks rock NNS cord-104204-pdnkabwj 87 21 , , , cord-104204-pdnkabwj 87 22 soils soil NNS cord-104204-pdnkabwj 87 23 , , , cord-104204-pdnkabwj 87 24 water water NN cord-104204-pdnkabwj 87 25 , , , cord-104204-pdnkabwj 87 26 and and CC cord-104204-pdnkabwj 87 27 foodstuff foodstuff NN cord-104204-pdnkabwj 87 28 from from IN cord-104204-pdnkabwj 87 29 Serbia Serbia NNP cord-104204-pdnkabwj 87 30 , , , cord-104204-pdnkabwj 87 31 as as RB cord-104204-pdnkabwj 87 32 well well RB cord-104204-pdnkabwj 87 33 as as IN cord-104204-pdnkabwj 87 34 in in IN cord-104204-pdnkabwj 87 35 serum serum NN cord-104204-pdnkabwj 87 36 samples sample NNS cord-104204-pdnkabwj 87 37 collected collect VBN cord-104204-pdnkabwj 87 38 from from IN cord-104204-pdnkabwj 87 39 endemic endemic JJ cord-104204-pdnkabwj 87 40 and and CC cord-104204-pdnkabwj 87 41 nonendemic nonendemic JJ cord-104204-pdnkabwj 87 42 regions region NNS cord-104204-pdnkabwj 87 43 ( ( -LRB- cord-104204-pdnkabwj 87 44 Fig Fig NNP cord-104204-pdnkabwj 87 45 . . NNP cord-104204-pdnkabwj 87 46 2 2 CD cord-104204-pdnkabwj 87 47 ) ) -RRB- cord-104204-pdnkabwj 87 48 . . . cord-104204-pdnkabwj 88 1 In in IN cord-104204-pdnkabwj 88 2 certain certain JJ cord-104204-pdnkabwj 88 3 endemic endemic JJ cord-104204-pdnkabwj 88 4 locations location NNS cord-104204-pdnkabwj 88 5 , , , cord-104204-pdnkabwj 88 6 levels level NNS cord-104204-pdnkabwj 88 7 of of IN cord-104204-pdnkabwj 88 8 Se Se NNP cord-104204-pdnkabwj 88 9 deficiency deficiency NN cord-104204-pdnkabwj 88 10 approach approach NN cord-104204-pdnkabwj 88 11 those those DT cord-104204-pdnkabwj 88 12 encountered encounter VBN cord-104204-pdnkabwj 88 13 in in IN cord-104204-pdnkabwj 88 14 the the DT cord-104204-pdnkabwj 88 15 Keshan Keshan NNP cord-104204-pdnkabwj 88 16 province province NN cord-104204-pdnkabwj 88 17 in in IN cord-104204-pdnkabwj 88 18 China China NNP cord-104204-pdnkabwj 88 19 , , , cord-104204-pdnkabwj 88 20 where where WRB cord-104204-pdnkabwj 88 21 a a DT cord-104204-pdnkabwj 88 22 severe severe JJ cord-104204-pdnkabwj 88 23 cardiomyopathy cardiomyopathy NN cord-104204-pdnkabwj 88 24 linked link VBN cord-104204-pdnkabwj 88 25 to to IN cord-104204-pdnkabwj 88 26 Se Se NNP cord-104204-pdnkabwj 88 27 deficiency deficiency NN cord-104204-pdnkabwj 88 28 is be VBZ cord-104204-pdnkabwj 88 29 endemic endemic JJ cord-104204-pdnkabwj 88 30 ( ( -LRB- cord-104204-pdnkabwj 88 31 25 25 CD cord-104204-pdnkabwj 88 32 ) ) -RRB- cord-104204-pdnkabwj 88 33 . . . cord-104204-pdnkabwj 89 1 Environmental Environmental NNP cord-104204-pdnkabwj 89 2 Health Health NNP cord-104204-pdnkabwj 89 3 Perspectives Perspectives NNPS cord-104204-pdnkabwj 89 4 * * NFP cord-104204-pdnkabwj 89 5 Volume volume NN cord-104204-pdnkabwj 89 6 106 106 CD cord-104204-pdnkabwj 89 7 , , , cord-104204-pdnkabwj 90 1 Number number NN cord-104204-pdnkabwj 90 2 1 1 CD cord-104204-pdnkabwj 90 3 1 1 CD cord-104204-pdnkabwj 90 4 , , , cord-104204-pdnkabwj 90 5 November November NNP cord-104204-pdnkabwj 90 6 1998 1998 CD cord-104204-pdnkabwj 91 1 Reviews review NNS cord-104204-pdnkabwj 92 1 a a DT cord-104204-pdnkabwj 92 2 Tatu Tatu NNP cord-104204-pdnkabwj 92 3 et et FW cord-104204-pdnkabwj 92 4 al al NNP cord-104204-pdnkabwj 92 5 . . . cord-104204-pdnkabwj 93 1 Although although IN cord-104204-pdnkabwj 93 2 no no DT cord-104204-pdnkabwj 93 3 known know VBN cord-104204-pdnkabwj 93 4 human human JJ cord-104204-pdnkabwj 93 5 kidney kidney NN cord-104204-pdnkabwj 93 6 disease disease NN cord-104204-pdnkabwj 93 7 has have VBZ cord-104204-pdnkabwj 93 8 been be VBN cord-104204-pdnkabwj 93 9 associated associate VBN cord-104204-pdnkabwj 93 10 with with IN cord-104204-pdnkabwj 93 11 a a DT cord-104204-pdnkabwj 93 12 low low JJ cord-104204-pdnkabwj 93 13 Se Se NNP cord-104204-pdnkabwj 93 14 intake intake NN cord-104204-pdnkabwj 93 15 , , , cord-104204-pdnkabwj 93 16 the the DT cord-104204-pdnkabwj 93 17 chemoprotective chemoprotective JJ cord-104204-pdnkabwj 93 18 effects effect NNS cord-104204-pdnkabwj 93 19 make make VBP cord-104204-pdnkabwj 93 20 this this DT cord-104204-pdnkabwj 93 21 metal metal NN cord-104204-pdnkabwj 93 22 an an DT cord-104204-pdnkabwj 93 23 essential essential JJ cord-104204-pdnkabwj 93 24 oligoelement oligoelement NN cord-104204-pdnkabwj 93 25 in in IN cord-104204-pdnkabwj 93 26 the the DT cord-104204-pdnkabwj 93 27 defense defense NN cord-104204-pdnkabwj 93 28 against against IN cord-104204-pdnkabwj 93 29 chemicals chemical NNS cord-104204-pdnkabwj 93 30 inducing induce VBG cord-104204-pdnkabwj 93 31 oxidative oxidative JJ cord-104204-pdnkabwj 93 32 damage damage NN cord-104204-pdnkabwj 93 33 and and CC cord-104204-pdnkabwj 93 34 cancer cancer NN cord-104204-pdnkabwj 93 35 . . . cord-104204-pdnkabwj 94 1 The the DT cord-104204-pdnkabwj 94 2 immune immune JJ cord-104204-pdnkabwj 94 3 antitumor antitumor JJ cord-104204-pdnkabwj 94 4 response response NN cord-104204-pdnkabwj 94 5 is be VBZ cord-104204-pdnkabwj 94 6 also also RB cord-104204-pdnkabwj 94 7 boosted boost VBN cord-104204-pdnkabwj 94 8 by by IN cord-104204-pdnkabwj 94 9 Se Se NNP cord-104204-pdnkabwj 94 10 ( ( -LRB- cord-104204-pdnkabwj 94 11 27 27 CD cord-104204-pdnkabwj 94 12 ) ) -RRB- cord-104204-pdnkabwj 94 13 and and CC cord-104204-pdnkabwj 94 14 , , , cord-104204-pdnkabwj 94 15 in in IN cord-104204-pdnkabwj 94 16 this this DT cord-104204-pdnkabwj 94 17 regard regard NN cord-104204-pdnkabwj 94 18 , , , cord-104204-pdnkabwj 94 19 Se Se NNP cord-104204-pdnkabwj 94 20 deficiency deficiency NN cord-104204-pdnkabwj 94 21 can can MD cord-104204-pdnkabwj 94 22 not not RB cord-104204-pdnkabwj 94 23 be be VB cord-104204-pdnkabwj 94 24 completely completely RB cord-104204-pdnkabwj 94 25 ruled rule VBN cord-104204-pdnkabwj 94 26 out out RP cord-104204-pdnkabwj 94 27 , , , cord-104204-pdnkabwj 94 28 given give VBN cord-104204-pdnkabwj 94 29 the the DT cord-104204-pdnkabwj 94 30 high high JJ cord-104204-pdnkabwj 94 31 incidence incidence NN cord-104204-pdnkabwj 94 32 of of IN cord-104204-pdnkabwj 94 33 UTTs utt NNS cord-104204-pdnkabwj 94 34 in in IN cord-104204-pdnkabwj 94 35 the the DT cord-104204-pdnkabwj 94 36 BEN BEN NNP cord-104204-pdnkabwj 94 37 endemic endemic JJ cord-104204-pdnkabwj 94 38 territories territory NNS cord-104204-pdnkabwj 94 39 . . . cord-104204-pdnkabwj 95 1 Genetic genetic JJ cord-104204-pdnkabwj 95 2 polymorphisms polymorphism NNS cord-104204-pdnkabwj 95 3 in in IN cord-104204-pdnkabwj 95 4 environmentally environmentally RB cord-104204-pdnkabwj 95 5 regulated regulate VBN cord-104204-pdnkabwj 95 6 genes gene NNS cord-104204-pdnkabwj 95 7 ( ( -LRB- cord-104204-pdnkabwj 95 8 such such JJ cord-104204-pdnkabwj 95 9 as as IN cord-104204-pdnkabwj 95 10 those those DT cord-104204-pdnkabwj 95 11 involved involve VBN cord-104204-pdnkabwj 95 12 in in IN cord-104204-pdnkabwj 95 13 the the DT cord-104204-pdnkabwj 95 14 distribution distribution NN cord-104204-pdnkabwj 95 15 , , , cord-104204-pdnkabwj 95 16 metabolism metabolism NN cord-104204-pdnkabwj 95 17 , , , cord-104204-pdnkabwj 95 18 and and CC cord-104204-pdnkabwj 95 19 disposal disposal NN cord-104204-pdnkabwj 95 20 of of IN cord-104204-pdnkabwj 95 21 toxic toxic JJ cord-104204-pdnkabwj 95 22 compounds compound NNS cord-104204-pdnkabwj 95 23 , , , cord-104204-pdnkabwj 95 24 and and CC cord-104204-pdnkabwj 95 25 DNA dna NN cord-104204-pdnkabwj 95 26 repair repair NN cord-104204-pdnkabwj 95 27 pathways pathway NNS cord-104204-pdnkabwj 95 28 and and CC cord-104204-pdnkabwj 95 29 their -PRON- PRP$ cord-104204-pdnkabwj 95 30 regulators regulator NNS cord-104204-pdnkabwj 95 31 ) ) -RRB- cord-104204-pdnkabwj 96 1 ( ( -LRB- cord-104204-pdnkabwj 96 2 28 28 CD cord-104204-pdnkabwj 96 3 ) ) -RRB- cord-104204-pdnkabwj 96 4 may may MD cord-104204-pdnkabwj 96 5 also also RB cord-104204-pdnkabwj 96 6 account account VB cord-104204-pdnkabwj 96 7 for for IN cord-104204-pdnkabwj 96 8 differential differential JJ cord-104204-pdnkabwj 96 9 susceptibility susceptibility NN cord-104204-pdnkabwj 96 10 to to IN cord-104204-pdnkabwj 96 11 BEN BEN NNP cord-104204-pdnkabwj 96 12 in in IN cord-104204-pdnkabwj 96 13 the the DT cord-104204-pdnkabwj 96 14 endemic endemic JJ cord-104204-pdnkabwj 96 15 region region NN cord-104204-pdnkabwj 96 16 population population NN cord-104204-pdnkabwj 96 17 and and CC cord-104204-pdnkabwj 96 18 particularly particularly RB cord-104204-pdnkabwj 96 19 to to IN cord-104204-pdnkabwj 96 20 upper upper JJ cord-104204-pdnkabwj 96 21 urinary urinary JJ cord-104204-pdnkabwj 96 22 tract tract NN cord-104204-pdnkabwj 96 23 oncogenesis oncogenesis NN cord-104204-pdnkabwj 96 24 . . . cord-104204-pdnkabwj 97 1 The the DT cord-104204-pdnkabwj 97 2 present present JJ cord-104204-pdnkabwj 97 3 paradigm paradigm NN cord-104204-pdnkabwj 97 4 is be VBZ cord-104204-pdnkabwj 97 5 that that IN cord-104204-pdnkabwj 97 6 BEN BEN NNP cord-104204-pdnkabwj 97 7 is be VBZ cord-104204-pdnkabwj 97 8 an an DT cord-104204-pdnkabwj 97 9 environmentally environmentally RB cord-104204-pdnkabwj 97 10 acquired acquire VBN cord-104204-pdnkabwj 97 11 disease disease NN cord-104204-pdnkabwj 97 12 . . . cord-104204-pdnkabwj 98 1 Currently currently RB cord-104204-pdnkabwj 98 2 , , , cord-104204-pdnkabwj 98 3 the the DT cord-104204-pdnkabwj 98 4 two two CD cord-104204-pdnkabwj 98 5 most most RBS cord-104204-pdnkabwj 98 6 plausible plausible JJ cord-104204-pdnkabwj 98 7 environmental environmental JJ cord-104204-pdnkabwj 98 8 agents agent NNS cord-104204-pdnkabwj 98 9 supposedly supposedly RB cord-104204-pdnkabwj 98 10 involved involve VBN cord-104204-pdnkabwj 98 11 in in IN cord-104204-pdnkabwj 98 12 its -PRON- PRP$ cord-104204-pdnkabwj 98 13 etiology etiology NN cord-104204-pdnkabwj 98 14 are be VBP cord-104204-pdnkabwj 98 15 mycotoxins mycotoxin NNS cord-104204-pdnkabwj 98 16 produced produce VBN cord-104204-pdnkabwj 98 17 by by IN cord-104204-pdnkabwj 98 18 fungi fungus NNS cord-104204-pdnkabwj 98 19 in in IN cord-104204-pdnkabwj 98 20 moldy moldy JJ cord-104204-pdnkabwj 98 21 cereals cereal NNS cord-104204-pdnkabwj 98 22 and and CC cord-104204-pdnkabwj 98 23 various various JJ cord-104204-pdnkabwj 98 24 food food NN cord-104204-pdnkabwj 98 25 commodities commodity NNS cord-104204-pdnkabwj 98 26 ( ( -LRB- cord-104204-pdnkabwj 98 27 grains grain NNS cord-104204-pdnkabwj 98 28 , , , cord-104204-pdnkabwj 98 29 meats meat NNS cord-104204-pdnkabwj 98 30 , , , cord-104204-pdnkabwj 98 31 beans bean NNS cord-104204-pdnkabwj 98 32 , , , cord-104204-pdnkabwj 98 33 etc etc FW cord-104204-pdnkabwj 98 34 . . . cord-104204-pdnkabwj 98 35 ) ) -RRB- cord-104204-pdnkabwj 99 1 from from IN cord-104204-pdnkabwj 99 2 endemic endemic JJ cord-104204-pdnkabwj 99 3 areas area NNS cord-104204-pdnkabwj 99 4 , , , cord-104204-pdnkabwj 99 5 and and CC cord-104204-pdnkabwj 99 6 aromatic aromatic JJ cord-104204-pdnkabwj 99 7 compounds compound NNS cord-104204-pdnkabwj 99 8 present present JJ cord-104204-pdnkabwj 99 9 in in IN cord-104204-pdnkabwj 99 10 the the DT cord-104204-pdnkabwj 99 11 drinking drinking NN cord-104204-pdnkabwj 99 12 water water NN cord-104204-pdnkabwj 99 13 from from IN cord-104204-pdnkabwj 99 14 the the DT cord-104204-pdnkabwj 99 15 endemic endemic JJ cord-104204-pdnkabwj 99 16 areas area NNS cord-104204-pdnkabwj 99 17 ( ( -LRB- cord-104204-pdnkabwj 99 18 29 29 CD cord-104204-pdnkabwj 99 19 ) ) -RRB- cord-104204-pdnkabwj 99 20 . . . cord-104204-pdnkabwj 100 1 The the DT cord-104204-pdnkabwj 100 2 mycotoxin mycotoxin NN cord-104204-pdnkabwj 100 3 cause cause NN cord-104204-pdnkabwj 100 4 for for IN cord-104204-pdnkabwj 100 5 BEN BEN NNP cord-104204-pdnkabwj 100 6 gained gain VBD cord-104204-pdnkabwj 100 7 support support NN cord-104204-pdnkabwj 100 8 more more JJR cord-104204-pdnkabwj 100 9 than than IN cord-104204-pdnkabwj 100 10 20 20 CD cord-104204-pdnkabwj 100 11 years year NNS cord-104204-pdnkabwj 100 12 ago ago RB cord-104204-pdnkabwj 100 13 ( ( -LRB- cord-104204-pdnkabwj 100 14 30 30 CD cord-104204-pdnkabwj 100 15 - - SYM cord-104204-pdnkabwj 100 16 32 32 CD cord-104204-pdnkabwj 100 17 ) ) -RRB- cord-104204-pdnkabwj 100 18 when when WRB cord-104204-pdnkabwj 100 19 a a DT cord-104204-pdnkabwj 100 20 striking strike VBG cord-104204-pdnkabwj 100 21 morphopathological morphopathological JJ cord-104204-pdnkabwj 100 22 and and CC cord-104204-pdnkabwj 100 23 epidemiological epidemiological JJ cord-104204-pdnkabwj 100 24 analogy analogy NN cord-104204-pdnkabwj 100 25 between between IN cord-104204-pdnkabwj 100 26 porcine porcine JJ cord-104204-pdnkabwj 100 27 mycotoxic mycotoxic NNP cord-104204-pdnkabwj 100 28 nephropathy nephropathy NN cord-104204-pdnkabwj 100 29 , , , cord-104204-pdnkabwj 100 30 caused cause VBN cord-104204-pdnkabwj 100 31 by by IN cord-104204-pdnkabwj 100 32 ochratoxin ochratoxin NNP cord-104204-pdnkabwj 100 33 A A NNP cord-104204-pdnkabwj 100 34 ( ( -LRB- cord-104204-pdnkabwj 100 35 OTA OTA NNP cord-104204-pdnkabwj 100 36 ) ) -RRB- cord-104204-pdnkabwj 100 37 , , , cord-104204-pdnkabwj 100 38 and and CC cord-104204-pdnkabwj 100 39 BEN BEN NNP cord-104204-pdnkabwj 100 40 was be VBD cord-104204-pdnkabwj 100 41 observed observe VBN cord-104204-pdnkabwj 100 42 . . . cord-104204-pdnkabwj 101 1 OTA OTA NNP cord-104204-pdnkabwj 101 2 is be VBZ cord-104204-pdnkabwj 101 3 produced produce VBN cord-104204-pdnkabwj 101 4 in in IN cord-104204-pdnkabwj 101 5 temperate temperate JJ cord-104204-pdnkabwj 101 6 and and CC cord-104204-pdnkabwj 101 7 subtropical subtropical JJ cord-104204-pdnkabwj 101 8 regions region NNS cord-104204-pdnkabwj 101 9 mainly mainly RB cord-104204-pdnkabwj 101 10 by by IN cord-104204-pdnkabwj 101 11 fungi fungus NNS cord-104204-pdnkabwj 101 12 of of IN cord-104204-pdnkabwj 101 13 genus genus NN cord-104204-pdnkabwj 101 14 Penicillium penicillium NN cord-104204-pdnkabwj 102 1 ( ( -LRB- cord-104204-pdnkabwj 102 2 i.e. i.e. FW cord-104204-pdnkabwj 102 3 , , , cord-104204-pdnkabwj 102 4 P. P. NNP cord-104204-pdnkabwj 102 5 verrucosum verrucosum NN cord-104204-pdnkabwj 102 6 , , , cord-104204-pdnkabwj 102 7 P. P. NNP cord-104204-pdnkabwj 102 8 cyclopium cyclopium NN cord-104204-pdnkabwj 102 9 , , , cord-104204-pdnkabwj 102 10 P. P. NNP cord-104204-pdnkabwj 102 11 chrysogenum chrysogenum NNP cord-104204-pdnkabwj 102 12 , , , cord-104204-pdnkabwj 102 13 etc etc FW cord-104204-pdnkabwj 102 14 . . . cord-104204-pdnkabwj 102 15 ) ) -RRB- cord-104204-pdnkabwj 102 16 and and CC cord-104204-pdnkabwj 102 17 Aspergillus aspergillus NN cord-104204-pdnkabwj 102 18 ( ( -LRB- cord-104204-pdnkabwj 102 19 A. A. NNP cord-104204-pdnkabwj 102 20 ochraceus ochraceus NNP cord-104204-pdnkabwj 102 21 , , , cord-104204-pdnkabwj 102 22 A a DT cord-104204-pdnkabwj 102 23 alliaceus alliaceu NNS cord-104204-pdnkabwj 102 24 , , , cord-104204-pdnkabwj 102 25 A. a. NN cord-104204-pdnkabwj 102 26 elegans elegan NNS cord-104204-pdnkabwj 102 27 , , , cord-104204-pdnkabwj 102 28 etc etc FW cord-104204-pdnkabwj 102 29 . . . cord-104204-pdnkabwj 102 30 ) ) -RRB- cord-104204-pdnkabwj 103 1 ( ( -LRB- cord-104204-pdnkabwj 103 2 33 33 CD cord-104204-pdnkabwj 103 3 , , , cord-104204-pdnkabwj 103 4 34 34 CD cord-104204-pdnkabwj 103 5 ) ) -RRB- cord-104204-pdnkabwj 103 6 . . . cord-104204-pdnkabwj 104 1 Subsequent subsequent JJ cord-104204-pdnkabwj 104 2 investigations investigation NNS cord-104204-pdnkabwj 104 3 , , , cord-104204-pdnkabwj 104 4 which which WDT cord-104204-pdnkabwj 104 5 revealed reveal VBD cord-104204-pdnkabwj 104 6 a a DT cord-104204-pdnkabwj 104 7 high high JJ cord-104204-pdnkabwj 104 8 frequency frequency NN cord-104204-pdnkabwj 104 9 of of IN cord-104204-pdnkabwj 104 10 OTA ota NN cord-104204-pdnkabwj 104 11 contamination contamination NN cord-104204-pdnkabwj 104 12 of of IN cord-104204-pdnkabwj 104 13 foodstuffs foodstuff NNS cord-104204-pdnkabwj 104 14 from from IN cord-104204-pdnkabwj 104 15 Yugoslavian yugoslavian JJ cord-104204-pdnkabwj 104 16 and and CC cord-104204-pdnkabwj 104 17 Bulgarian bulgarian JJ cord-104204-pdnkabwj 104 18 endemic endemic JJ cord-104204-pdnkabwj 104 19 regions region NNS cord-104204-pdnkabwj 104 20 , , , cord-104204-pdnkabwj 104 21 higher high JJR cord-104204-pdnkabwj 104 22 levels level NNS cord-104204-pdnkabwj 104 23 of of IN cord-104204-pdnkabwj 104 24 OTA ota NN cord-104204-pdnkabwj 104 25 in in IN cord-104204-pdnkabwj 104 26 foodstuffs foodstuff NNS cord-104204-pdnkabwj 104 27 from from IN cord-104204-pdnkabwj 104 28 endemic endemic JJ cord-104204-pdnkabwj 104 29 versus versus IN cord-104204-pdnkabwj 104 30 nonendemic nonendemic NNP cord-104204-pdnkabwj 104 31 villages village NNS cord-104204-pdnkabwj 104 32 and and CC cord-104204-pdnkabwj 104 33 in in IN cord-104204-pdnkabwj 104 34 the the DT cord-104204-pdnkabwj 104 35 blood blood NN cord-104204-pdnkabwj 104 36 of of IN cord-104204-pdnkabwj 104 37 BEN BEN NNP cord-104204-pdnkabwj 104 38 patients patient NNS cord-104204-pdnkabwj 104 39 versus versus IN cord-104204-pdnkabwj 104 40 individuals individual NNS cord-104204-pdnkabwj 104 41 from from IN cord-104204-pdnkabwj 104 42 nonendemic nonendemic NNP cord-104204-pdnkabwj 104 43 regions region NNS cord-104204-pdnkabwj 104 44 , , , cord-104204-pdnkabwj 104 45 and and CC cord-104204-pdnkabwj 104 46 the the DT cord-104204-pdnkabwj 104 47 detection detection NN cord-104204-pdnkabwj 104 48 of of IN cord-104204-pdnkabwj 104 49 several several JJ cord-104204-pdnkabwj 104 50 characteristic characteristic JJ cord-104204-pdnkabwj 104 51 OTA ota NN cord-104204-pdnkabwj 104 52 - - HYPH cord-104204-pdnkabwj 104 53 DNA dna NN cord-104204-pdnkabwj 104 54 adducts adduct NNS cord-104204-pdnkabwj 104 55 in in IN cord-104204-pdnkabwj 104 56 urinary urinary JJ cord-104204-pdnkabwj 104 57 tract tract JJ cord-104204-pdnkabwj 104 58 tumors tumor NNS cord-104204-pdnkabwj 104 59 from from IN cord-104204-pdnkabwj 104 60 Bulgarian bulgarian JJ cord-104204-pdnkabwj 104 61 individuals individual NNS cord-104204-pdnkabwj 104 62 living live VBG cord-104204-pdnkabwj 104 63 in in IN cord-104204-pdnkabwj 104 64 BEN BEN NNP cord-104204-pdnkabwj 104 65 endemic endemic JJ cord-104204-pdnkabwj 104 66 regions region NNS cord-104204-pdnkabwj 104 67 ( ( -LRB- cord-104204-pdnkabwj 104 68 35 35 CD cord-104204-pdnkabwj 104 69 , , , cord-104204-pdnkabwj 104 70 36 36 CD cord-104204-pdnkabwj 104 71 ) ) -RRB- cord-104204-pdnkabwj 104 72 , , , cord-104204-pdnkabwj 104 73 substantiated substantiate VBD cord-104204-pdnkabwj 104 74 this this DT cord-104204-pdnkabwj 104 75 hypothesis hypothesis NN cord-104204-pdnkabwj 104 76 . . . cord-104204-pdnkabwj 105 1 The the DT cord-104204-pdnkabwj 105 2 recent recent JJ cord-104204-pdnkabwj 105 3 description description NN cord-104204-pdnkabwj 105 4 of of IN cord-104204-pdnkabwj 105 5 a a DT cord-104204-pdnkabwj 105 6 BEN BEN NNP cord-104204-pdnkabwj 105 7 - - HYPH cord-104204-pdnkabwj 105 8 like like JJ cord-104204-pdnkabwj 105 9 nephropathy nephropathy NN cord-104204-pdnkabwj 105 10 in in IN cord-104204-pdnkabwj 105 11 Tunisia Tunisia NNP cord-104204-pdnkabwj 105 12 , , , cord-104204-pdnkabwj 105 13 Africa Africa NNP cord-104204-pdnkabwj 105 14 ( ( -LRB- cord-104204-pdnkabwj 105 15 37 37 CD cord-104204-pdnkabwj 105 16 , , , cord-104204-pdnkabwj 105 17 38 38 CD cord-104204-pdnkabwj 105 18 ) ) -RRB- cord-104204-pdnkabwj 105 19 , , , cord-104204-pdnkabwj 105 20 which which WDT cord-104204-pdnkabwj 105 21 is be VBZ cord-104204-pdnkabwj 105 22 allegedly allegedly RB cord-104204-pdnkabwj 105 23 produced produce VBN cord-104204-pdnkabwj 105 24 by by IN cord-104204-pdnkabwj 105 25 OTA OTA NNP cord-104204-pdnkabwj 105 26 and and CC cord-104204-pdnkabwj 105 27 of of IN cord-104204-pdnkabwj 105 28 a a DT cord-104204-pdnkabwj 105 29 possible possible JJ cord-104204-pdnkabwj 105 30 causal causal JJ cord-104204-pdnkabwj 105 31 link link NN cord-104204-pdnkabwj 105 32 between between IN cord-104204-pdnkabwj 105 33 OTA OTA NNP cord-104204-pdnkabwj 105 34 and and CC cord-104204-pdnkabwj 105 35 the the DT cord-104204-pdnkabwj 105 36 karyomegalic karyomegalic NNP cord-104204-pdnkabwj 105 37 interstitial interstitial JJ cord-104204-pdnkabwj 105 38 nephropathy nephropathy NN cord-104204-pdnkabwj 105 39 ( ( -LRB- cord-104204-pdnkabwj 105 40 33 33 CD cord-104204-pdnkabwj 105 41 ) ) -RRB- cord-104204-pdnkabwj 105 42 , , , cord-104204-pdnkabwj 105 43 a a DT cord-104204-pdnkabwj 105 44 form form NN cord-104204-pdnkabwj 105 45 of of IN cord-104204-pdnkabwj 105 46 nephropathy nephropathy NN cord-104204-pdnkabwj 105 47 that that WDT cord-104204-pdnkabwj 105 48 resembles resemble VBZ cord-104204-pdnkabwj 105 49 BEN BEN NNP cord-104204-pdnkabwj 105 50 in in IN cord-104204-pdnkabwj 105 51 certain certain JJ cord-104204-pdnkabwj 105 52 morphopathological morphopathological JJ cord-104204-pdnkabwj 105 53 and and CC cord-104204-pdnkabwj 105 54 clinical clinical JJ cord-104204-pdnkabwj 105 55 aspects aspect NNS cord-104204-pdnkabwj 105 56 , , , cord-104204-pdnkabwj 105 57 also also RB cord-104204-pdnkabwj 105 58 strengthens strengthen VBZ cord-104204-pdnkabwj 105 59 the the DT cord-104204-pdnkabwj 105 60 idea idea NN cord-104204-pdnkabwj 105 61 of of IN cord-104204-pdnkabwj 105 62 an an DT cord-104204-pdnkabwj 105 63 OTA OTA NNP cord-104204-pdnkabwj 105 64 etiology etiology NN cord-104204-pdnkabwj 105 65 of of IN cord-104204-pdnkabwj 105 66 BEN BEN NNP cord-104204-pdnkabwj 105 67 . . . cord-104204-pdnkabwj 106 1 OTA OTA NNP cord-104204-pdnkabwj 106 2 , , , cord-104204-pdnkabwj 106 3 however however RB cord-104204-pdnkabwj 106 4 , , , cord-104204-pdnkabwj 106 5 is be VBZ cord-104204-pdnkabwj 106 6 a a DT cord-104204-pdnkabwj 106 7 relatively relatively RB cord-104204-pdnkabwj 106 8 common common JJ cord-104204-pdnkabwj 106 9 contaminant contaminant NN cord-104204-pdnkabwj 106 10 of of IN cord-104204-pdnkabwj 106 11 various various JJ cord-104204-pdnkabwj 106 12 foodstuffs foodstuff NNS cord-104204-pdnkabwj 106 13 in in IN cord-104204-pdnkabwj 106 14 many many JJ cord-104204-pdnkabwj 106 15 countries country NNS cord-104204-pdnkabwj 106 16 with with IN cord-104204-pdnkabwj 106 17 temperate temperate JJ cord-104204-pdnkabwj 106 18 continental continental JJ cord-104204-pdnkabwj 106 19 dimate dimate NN cord-104204-pdnkabwj 106 20 and and CC cord-104204-pdnkabwj 106 21 can can MD cord-104204-pdnkabwj 106 22 be be VB cord-104204-pdnkabwj 106 23 sporadically sporadically RB cord-104204-pdnkabwj 106 24 found find VBN cord-104204-pdnkabwj 106 25 in in IN cord-104204-pdnkabwj 106 26 the the DT cord-104204-pdnkabwj 106 27 blood blood NN cord-104204-pdnkabwj 106 28 of of IN cord-104204-pdnkabwj 106 29 healthy healthy JJ cord-104204-pdnkabwj 106 30 individuals individual NNS cord-104204-pdnkabwj 106 31 . . . cord-104204-pdnkabwj 107 1 This this DT cord-104204-pdnkabwj 107 2 hypothesis hypothesis NN cord-104204-pdnkabwj 107 3 also also RB cord-104204-pdnkabwj 107 4 leaves leave VBZ cord-104204-pdnkabwj 107 5 unclear unclear JJ cord-104204-pdnkabwj 107 6 the the DT cord-104204-pdnkabwj 107 7 fact fact NN cord-104204-pdnkabwj 107 8 whether whether IN cord-104204-pdnkabwj 107 9 OTA OTA NNP cord-104204-pdnkabwj 107 10 is be VBZ cord-104204-pdnkabwj 107 11 the the DT cord-104204-pdnkabwj 107 12 principal principal JJ cord-104204-pdnkabwj 107 13 etiologic etiologic JJ cord-104204-pdnkabwj 107 14 factor factor NN cord-104204-pdnkabwj 107 15 in in IN cord-104204-pdnkabwj 107 16 BEN BEN NNP cord-104204-pdnkabwj 107 17 , , , cord-104204-pdnkabwj 107 18 or or CC cord-104204-pdnkabwj 107 19 only only RB cord-104204-pdnkabwj 107 20 a a DT cord-104204-pdnkabwj 107 21 cofactor cofactor NN cord-104204-pdnkabwj 107 22 that that IN cord-104204-pdnkabwj 107 23 , , , cord-104204-pdnkabwj 107 24 although although IN cord-104204-pdnkabwj 107 25 required require VBN cord-104204-pdnkabwj 107 26 , , , cord-104204-pdnkabwj 107 27 is be VBZ cord-104204-pdnkabwj 107 28 not not RB cord-104204-pdnkabwj 107 29 enough enough JJ cord-104204-pdnkabwj 107 30 to to TO cord-104204-pdnkabwj 107 31 produce produce VB cord-104204-pdnkabwj 107 32 BEN BEN NNP cord-104204-pdnkabwj 107 33 itself -PRON- PRP cord-104204-pdnkabwj 107 34 . . . cord-104204-pdnkabwj 108 1 A a DT cord-104204-pdnkabwj 108 2 major major JJ cord-104204-pdnkabwj 108 3 caveat caveat NN cord-104204-pdnkabwj 108 4 in in IN cord-104204-pdnkabwj 108 5 studies study NNS cord-104204-pdnkabwj 108 6 of of IN cord-104204-pdnkabwj 108 7 OTA OTA NNP cord-104204-pdnkabwj 108 8 related relate VBN cord-104204-pdnkabwj 108 9 to to IN cord-104204-pdnkabwj 108 10 BEN BEN NNP cord-104204-pdnkabwj 108 11 is be VBZ cord-104204-pdnkabwj 108 12 that that IN cord-104204-pdnkabwj 108 13 the the DT cord-104204-pdnkabwj 108 14 higher high JJR cord-104204-pdnkabwj 108 15 levels level NNS cord-104204-pdnkabwj 108 16 of of IN cord-104204-pdnkabwj 108 17 OTA OTA NNP cord-104204-pdnkabwj 108 18 found find VBN cord-104204-pdnkabwj 108 19 in in IN cord-104204-pdnkabwj 108 20 the the DT cord-104204-pdnkabwj 108 21 serum serum NN cord-104204-pdnkabwj 108 22 of of IN cord-104204-pdnkabwj 108 23 BEN BEN NNP cord-104204-pdnkabwj 108 24 patients patient NNS cord-104204-pdnkabwj 108 25 compared compare VBN cord-104204-pdnkabwj 108 26 to to IN cord-104204-pdnkabwj 108 27 controls control NNS cord-104204-pdnkabwj 108 28 may may MD cord-104204-pdnkabwj 108 29 be be VB cord-104204-pdnkabwj 108 30 the the DT cord-104204-pdnkabwj 108 31 consequence consequence NN cord-104204-pdnkabwj 108 32 of of IN cord-104204-pdnkabwj 108 33 secondary secondary JJ cord-104204-pdnkabwj 108 34 accumulation accumulation NN cord-104204-pdnkabwj 108 35 of of IN cord-104204-pdnkabwj 108 36 OTA OTA NNP cord-104204-pdnkabwj 108 37 , , , cord-104204-pdnkabwj 108 38 following follow VBG cord-104204-pdnkabwj 108 39 the the DT cord-104204-pdnkabwj 108 40 impairment impairment NN cord-104204-pdnkabwj 108 41 of of IN cord-104204-pdnkabwj 108 42 kidney kidney NN cord-104204-pdnkabwj 108 43 transport transport NN cord-104204-pdnkabwj 108 44 and and CC cord-104204-pdnkabwj 108 45 excretion excretion NN cord-104204-pdnkabwj 108 46 functions function NNS cord-104204-pdnkabwj 108 47 by by IN cord-104204-pdnkabwj 108 48 the the DT cord-104204-pdnkabwj 108 49 original original JJ cord-104204-pdnkabwj 108 50 etiological etiological JJ cord-104204-pdnkabwj 108 51 agent agent NN cord-104204-pdnkabwj 108 52 rather rather RB cord-104204-pdnkabwj 108 53 than than IN cord-104204-pdnkabwj 108 54 reflecting reflect VBG cord-104204-pdnkabwj 108 55 the the DT cord-104204-pdnkabwj 108 56 natural natural JJ cord-104204-pdnkabwj 108 57 exposure exposure NN cord-104204-pdnkabwj 108 58 to to IN cord-104204-pdnkabwj 108 59 OTA OTA NNP cord-104204-pdnkabwj 108 60 . . . cord-104204-pdnkabwj 109 1 Also also RB cord-104204-pdnkabwj 109 2 , , , cord-104204-pdnkabwj 109 3 if if IN cord-104204-pdnkabwj 109 4 OTA OTA NNP cord-104204-pdnkabwj 109 5 were be VBD cord-104204-pdnkabwj 109 6 the the DT cord-104204-pdnkabwj 109 7 only only JJ cord-104204-pdnkabwj 109 8 etiological etiological JJ cord-104204-pdnkabwj 109 9 factor factor NN cord-104204-pdnkabwj 109 10 for for IN cord-104204-pdnkabwj 109 11 BEN BEN NNP cord-104204-pdnkabwj 109 12 , , , cord-104204-pdnkabwj 109 13 one one PRP cord-104204-pdnkabwj 109 14 would would MD cord-104204-pdnkabwj 109 15 expect expect VB cord-104204-pdnkabwj 109 16 to to TO cord-104204-pdnkabwj 109 17 find find VB cord-104204-pdnkabwj 109 18 cases case NNS cord-104204-pdnkabwj 109 19 of of IN cord-104204-pdnkabwj 109 20 BEN BEN NNP cord-104204-pdnkabwj 109 21 or or CC cord-104204-pdnkabwj 109 22 BEN BEN NNP cord-104204-pdnkabwj 109 23 - - HYPH cord-104204-pdnkabwj 109 24 like like JJ cord-104204-pdnkabwj 109 25 disease disease NN cord-104204-pdnkabwj 109 26 in in IN cord-104204-pdnkabwj 109 27 many many JJ cord-104204-pdnkabwj 109 28 other other JJ cord-104204-pdnkabwj 109 29 places place NNS cord-104204-pdnkabwj 109 30 around around IN cord-104204-pdnkabwj 109 31 the the DT cord-104204-pdnkabwj 109 32 world world NN cord-104204-pdnkabwj 109 33 where where WRB cord-104204-pdnkabwj 109 34 food food NN cord-104204-pdnkabwj 109 35 contamination contamination NN cord-104204-pdnkabwj 109 36 with with IN cord-104204-pdnkabwj 109 37 OTA OTA NNP cord-104204-pdnkabwj 109 38 has have VBZ cord-104204-pdnkabwj 109 39 been be VBN cord-104204-pdnkabwj 109 40 reported report VBN cord-104204-pdnkabwj 109 41 ( ( -LRB- cord-104204-pdnkabwj 109 42 e.g. e.g. RB cord-104204-pdnkabwj 109 43 , , , cord-104204-pdnkabwj 109 44 in in IN cord-104204-pdnkabwj 109 45 the the DT cord-104204-pdnkabwj 109 46 United United NNP cord-104204-pdnkabwj 109 47 Kingdom Kingdom NNP cord-104204-pdnkabwj 109 48 or or CC cord-104204-pdnkabwj 109 49 Italy Italy NNP cord-104204-pdnkabwj 109 50 where where WRB cord-104204-pdnkabwj 109 51 the the DT cord-104204-pdnkabwj 109 52 highest high JJS cord-104204-pdnkabwj 109 53 levels level NNS cord-104204-pdnkabwj 109 54 of of IN cord-104204-pdnkabwj 109 55 OTA ota NN cord-104204-pdnkabwj 109 56 contamination contamination NN cord-104204-pdnkabwj 109 57 of of IN cord-104204-pdnkabwj 109 58 certain certain JJ cord-104204-pdnkabwj 109 59 food food NN cord-104204-pdnkabwj 109 60 commodities commodity NNS cord-104204-pdnkabwj 109 61 , , , cord-104204-pdnkabwj 109 62 moldy moldy JJ cord-104204-pdnkabwj 109 63 wheat wheat NN cord-104204-pdnkabwj 109 64 flour flour NN cord-104204-pdnkabwj 109 65 and and CC cord-104204-pdnkabwj 109 66 moldy moldy JJ cord-104204-pdnkabwj 109 67 bread bread NN cord-104204-pdnkabwj 109 68 , , , cord-104204-pdnkabwj 109 69 respectively respectively RB cord-104204-pdnkabwj 109 70 , , , cord-104204-pdnkabwj 109 71 have have VBP cord-104204-pdnkabwj 109 72 been be VBN cord-104204-pdnkabwj 109 73 observed observe VBN cord-104204-pdnkabwj 109 74 ) ) -RRB- cord-104204-pdnkabwj 109 75 or or CC cord-104204-pdnkabwj 109 76 in in IN cord-104204-pdnkabwj 109 77 countries country NNS cord-104204-pdnkabwj 109 78 where where WRB cord-104204-pdnkabwj 109 79 a a DT cord-104204-pdnkabwj 109 80 high high JJ cord-104204-pdnkabwj 109 81 prevalence prevalence NN cord-104204-pdnkabwj 109 82 of of IN cord-104204-pdnkabwj 109 83 human human JJ cord-104204-pdnkabwj 109 84 sera sera NNP cord-104204-pdnkabwj 109 85 contamination contamination NN cord-104204-pdnkabwj 109 86 with with IN cord-104204-pdnkabwj 109 87 OTA OTA NNP cord-104204-pdnkabwj 109 88 was be VBD cord-104204-pdnkabwj 109 89 detected detect VBN cord-104204-pdnkabwj 109 90 ( ( -LRB- cord-104204-pdnkabwj 109 91 for for IN cord-104204-pdnkabwj 109 92 instance instance NN cord-104204-pdnkabwj 109 93 in in IN cord-104204-pdnkabwj 109 94 France France NNP cord-104204-pdnkabwj 109 95 , , , cord-104204-pdnkabwj 109 96 Denmark Denmark NNP cord-104204-pdnkabwj 109 97 , , , cord-104204-pdnkabwj 109 98 and and CC cord-104204-pdnkabwj 109 99 Germany Germany NNP cord-104204-pdnkabwj 109 100 , , , cord-104204-pdnkabwj 109 101 where where WRB cord-104204-pdnkabwj 109 102 OTA OTA NNP cord-104204-pdnkabwj 109 103 was be VBD cord-104204-pdnkabwj 109 104 found find VBN cord-104204-pdnkabwj 109 105 in in IN cord-104204-pdnkabwj 109 106 22 22 CD cord-104204-pdnkabwj 109 107 % % NN cord-104204-pdnkabwj 109 108 , , , cord-104204-pdnkabwj 109 109 54.2 54.2 CD cord-104204-pdnkabwj 109 110 % % NN cord-104204-pdnkabwj 109 111 , , , cord-104204-pdnkabwj 109 112 and and CC cord-104204-pdnkabwj 109 113 56.5 56.5 CD cord-104204-pdnkabwj 109 114 - - HYPH cord-104204-pdnkabwj 109 115 68.1 68.1 CD cord-104204-pdnkabwj 109 116 % % NN cord-104204-pdnkabwj 109 117 of of IN cord-104204-pdnkabwj 109 118 serum serum NN cord-104204-pdnkabwj 109 119 samples sample NNS cord-104204-pdnkabwj 109 120 , , , cord-104204-pdnkabwj 109 121 respectively respectively RB cord-104204-pdnkabwj 109 122 ) ) -RRB- cord-104204-pdnkabwj 109 123 [ [ -LRB- cord-104204-pdnkabwj 109 124 reviewed review VBN cord-104204-pdnkabwj 109 125 by by IN cord-104204-pdnkabwj 109 126 Godin Godin NNP cord-104204-pdnkabwj 109 127 et et NNP cord-104204-pdnkabwj 109 128 al al NNP cord-104204-pdnkabwj 109 129 . . . cord-104204-pdnkabwj 110 1 ( ( -LRB- cord-104204-pdnkabwj 110 2 33 33 CD cord-104204-pdnkabwj 110 3 ) ) -RRB- cord-104204-pdnkabwj 110 4 ] ] -RRB- cord-104204-pdnkabwj 110 5 . . . cord-104204-pdnkabwj 111 1 BEN BEN NNP cord-104204-pdnkabwj 111 2 , , , cord-104204-pdnkabwj 111 3 however however RB cord-104204-pdnkabwj 111 4 , , , cord-104204-pdnkabwj 111 5 seems seem VBZ cord-104204-pdnkabwj 111 6 to to TO cord-104204-pdnkabwj 111 7 be be VB cord-104204-pdnkabwj 111 8 unique unique JJ cord-104204-pdnkabwj 111 9 in in IN cord-104204-pdnkabwj 111 10 its -PRON- PRP$ cord-104204-pdnkabwj 111 11 geographical geographical JJ cord-104204-pdnkabwj 111 12 distribution distribution NN cord-104204-pdnkabwj 111 13 , , , cord-104204-pdnkabwj 111 14 evolution evolution NN cord-104204-pdnkabwj 111 15 , , , cord-104204-pdnkabwj 111 16 manifestation manifestation NN cord-104204-pdnkabwj 111 17 , , , cord-104204-pdnkabwj 111 18 and and CC cord-104204-pdnkabwj 111 19 pathology pathology NN cord-104204-pdnkabwj 111 20 . . . cord-104204-pdnkabwj 112 1 Although although IN cord-104204-pdnkabwj 112 2 several several JJ cord-104204-pdnkabwj 112 3 studies study NNS cord-104204-pdnkabwj 112 4 daim daim NNP cord-104204-pdnkabwj 112 5 that that IN cord-104204-pdnkabwj 112 6 BEN BEN NNP cord-104204-pdnkabwj 112 7 could could MD cord-104204-pdnkabwj 112 8 be be VB cord-104204-pdnkabwj 112 9 a a DT cord-104204-pdnkabwj 112 10 disease disease NN cord-104204-pdnkabwj 112 11 " " '' cord-104204-pdnkabwj 112 12 beyond beyond IN cord-104204-pdnkabwj 112 13 the the DT cord-104204-pdnkabwj 112 14 Balkans Balkans NNPS cord-104204-pdnkabwj 112 15 " " '' cord-104204-pdnkabwj 112 16 ( ( -LRB- cord-104204-pdnkabwj 112 17 39 39 CD cord-104204-pdnkabwj 112 18 ) ) -RRB- cord-104204-pdnkabwj 112 19 , , , cord-104204-pdnkabwj 112 20 more more JJR cord-104204-pdnkabwj 112 21 research research NN cord-104204-pdnkabwj 112 22 will will MD cord-104204-pdnkabwj 112 23 be be VB cord-104204-pdnkabwj 112 24 needed need VBN cord-104204-pdnkabwj 112 25 to to TO cord-104204-pdnkabwj 112 26 darify darify VB cord-104204-pdnkabwj 112 27 this this DT cord-104204-pdnkabwj 112 28 . . . cord-104204-pdnkabwj 113 1 An an DT cord-104204-pdnkabwj 113 2 alternative alternative JJ cord-104204-pdnkabwj 113 3 hypothesis hypothesis NN cord-104204-pdnkabwj 113 4 was be VBD cord-104204-pdnkabwj 113 5 formulated formulate VBN cord-104204-pdnkabwj 113 6 in in IN cord-104204-pdnkabwj 113 7 1991 1991 CD cord-104204-pdnkabwj 113 8 based base VBN cord-104204-pdnkabwj 113 9 on on IN cord-104204-pdnkabwj 113 10 the the DT cord-104204-pdnkabwj 113 11 geographical geographical JJ cord-104204-pdnkabwj 113 12 correspondence correspondence NN cord-104204-pdnkabwj 113 13 between between IN cord-104204-pdnkabwj 113 14 the the DT cord-104204-pdnkabwj 113 15 location location NN cord-104204-pdnkabwj 113 16 of of IN cord-104204-pdnkabwj 113 17 Pliocene pliocene JJ cord-104204-pdnkabwj 113 18 lignite lignite NN cord-104204-pdnkabwj 113 19 deposits deposit NNS cord-104204-pdnkabwj 113 20 in in IN cord-104204-pdnkabwj 113 21 the the DT cord-104204-pdnkabwj 113 22 Balkans Balkans NNPS cord-104204-pdnkabwj 113 23 and and CC cord-104204-pdnkabwj 113 24 the the DT cord-104204-pdnkabwj 113 25 location location NN cord-104204-pdnkabwj 113 26 of of IN cord-104204-pdnkabwj 113 27 endemic endemic JJ cord-104204-pdnkabwj 113 28 areas area NNS cord-104204-pdnkabwj 113 29 , , , cord-104204-pdnkabwj 113 30 as as RB cord-104204-pdnkabwj 113 31 well well RB cord-104204-pdnkabwj 113 32 as as IN cord-104204-pdnkabwj 113 33 preliminary preliminary JJ cord-104204-pdnkabwj 113 34 geochemical geochemical JJ cord-104204-pdnkabwj 113 35 analyses analysis NNS cord-104204-pdnkabwj 113 36 of of IN cord-104204-pdnkabwj 113 37 well well JJ cord-104204-pdnkabwj 113 38 water water NN cord-104204-pdnkabwj 113 39 from from IN cord-104204-pdnkabwj 113 40 endemic endemic JJ cord-104204-pdnkabwj 113 41 villages village NNS cord-104204-pdnkabwj 113 42 in in IN cord-104204-pdnkabwj 113 43 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 113 44 , , , cord-104204-pdnkabwj 113 45 which which WDT cord-104204-pdnkabwj 113 46 showed show VBD cord-104204-pdnkabwj 113 47 the the DT cord-104204-pdnkabwj 113 48 presence presence NN cord-104204-pdnkabwj 113 49 of of IN cord-104204-pdnkabwj 113 50 organic organic JJ cord-104204-pdnkabwj 113 51 compounds compound NNS cord-104204-pdnkabwj 113 52 not not RB cord-104204-pdnkabwj 113 53 observed observe VBN cord-104204-pdnkabwj 113 54 in in IN cord-104204-pdnkabwj 113 55 well well JJ cord-104204-pdnkabwj 113 56 water water NN cord-104204-pdnkabwj 113 57 from from IN cord-104204-pdnkabwj 113 58 nonendemic nonendemic NNP cord-104204-pdnkabwj 113 59 villages village NNS cord-104204-pdnkabwj 113 60 ( ( -LRB- cord-104204-pdnkabwj 113 61 29 29 CD cord-104204-pdnkabwj 113 62 , , , cord-104204-pdnkabwj 113 63 40 40 CD cord-104204-pdnkabwj 113 64 ) ) -RRB- cord-104204-pdnkabwj 113 65 . . . cord-104204-pdnkabwj 114 1 All all DT cord-104204-pdnkabwj 114 2 endemic endemic JJ cord-104204-pdnkabwj 114 3 regions region NNS cord-104204-pdnkabwj 114 4 except except IN cord-104204-pdnkabwj 114 5 one one CD cord-104204-pdnkabwj 114 6 are be VBP cord-104204-pdnkabwj 114 7 in in IN cord-104204-pdnkabwj 114 8 close close JJ cord-104204-pdnkabwj 114 9 proximity proximity NN cord-104204-pdnkabwj 114 10 to to IN cord-104204-pdnkabwj 114 11 known know VBN cord-104204-pdnkabwj 114 12 deposits deposit NNS cord-104204-pdnkabwj 114 13 of of IN cord-104204-pdnkabwj 114 14 low low JJ cord-104204-pdnkabwj 114 15 rank rank NN cord-104204-pdnkabwj 114 16 coals coal NNS cord-104204-pdnkabwj 114 17 of of IN cord-104204-pdnkabwj 114 18 Tertiary tertiary JJ cord-104204-pdnkabwj 114 19 age age NN cord-104204-pdnkabwj 114 20 ( ( -LRB- cord-104204-pdnkabwj 114 21 Pliocene pliocene JJ cord-104204-pdnkabwj 114 22 lignites lignite NNS cord-104204-pdnkabwj 114 23 ) ) -RRB- cord-104204-pdnkabwj 115 1 ( ( -LRB- cord-104204-pdnkabwj 115 2 Fig Fig NNP cord-104204-pdnkabwj 115 3 . . . cord-104204-pdnkabwj 115 4 3 3 CD cord-104204-pdnkabwj 115 5 ) ) -RRB- cord-104204-pdnkabwj 115 6 . . . cord-104204-pdnkabwj 116 1 The the DT cord-104204-pdnkabwj 116 2 reason reason NN cord-104204-pdnkabwj 116 3 for for IN cord-104204-pdnkabwj 116 4 the the DT cord-104204-pdnkabwj 116 5 one one CD cord-104204-pdnkabwj 116 6 exception exception NN cord-104204-pdnkabwj 116 7 is be VBZ cord-104204-pdnkabwj 116 8 undear undear JJ cord-104204-pdnkabwj 116 9 . . . cord-104204-pdnkabwj 117 1 This this DT cord-104204-pdnkabwj 117 2 endemic endemic JJ cord-104204-pdnkabwj 117 3 area area NN cord-104204-pdnkabwj 117 4 is be VBZ cord-104204-pdnkabwj 117 5 in in IN cord-104204-pdnkabwj 117 6 central central JJ cord-104204-pdnkabwj 117 7 Serbia Serbia NNP cord-104204-pdnkabwj 117 8 and and CC cord-104204-pdnkabwj 117 9 does do VBZ cord-104204-pdnkabwj 117 10 have have VB cord-104204-pdnkabwj 117 11 some some DT cord-104204-pdnkabwj 117 12 nearby nearby JJ cord-104204-pdnkabwj 117 13 Pliocene pliocene JJ cord-104204-pdnkabwj 117 14 lignite lignite NN cord-104204-pdnkabwj 117 15 deposits deposit NNS cord-104204-pdnkabwj 117 16 , , , cord-104204-pdnkabwj 117 17 although although IN cord-104204-pdnkabwj 117 18 not not RB cord-104204-pdnkabwj 117 19 in in IN cord-104204-pdnkabwj 117 20 as as RB cord-104204-pdnkabwj 117 21 direct direct JJ cord-104204-pdnkabwj 117 22 proximity proximity NN cord-104204-pdnkabwj 117 23 as as IN cord-104204-pdnkabwj 117 24 found find VBN cord-104204-pdnkabwj 117 25 in in IN cord-104204-pdnkabwj 117 26 other other JJ cord-104204-pdnkabwj 117 27 endemic endemic JJ cord-104204-pdnkabwj 117 28 areas area NNS cord-104204-pdnkabwj 117 29 . . . cord-104204-pdnkabwj 118 1 This this DT cord-104204-pdnkabwj 118 2 area area NN cord-104204-pdnkabwj 118 3 of of IN cord-104204-pdnkabwj 118 4 exception exception NN cord-104204-pdnkabwj 118 5 may may MD cord-104204-pdnkabwj 118 6 have have VB cord-104204-pdnkabwj 118 7 uncharacterized uncharacterized JJ cord-104204-pdnkabwj 118 8 lignite lignite NN cord-104204-pdnkabwj 118 9 deposits deposit NNS cord-104204-pdnkabwj 118 10 or or CC cord-104204-pdnkabwj 118 11 be be VB cord-104204-pdnkabwj 118 12 hydrologically hydrologically RB cord-104204-pdnkabwj 118 13 connected connect VBN cord-104204-pdnkabwj 118 14 to to IN cord-104204-pdnkabwj 118 15 nearby nearby JJ cord-104204-pdnkabwj 118 16 lignite lignite JJ cord-104204-pdnkabwj 118 17 beds bed NNS cord-104204-pdnkabwj 118 18 . . . cord-104204-pdnkabwj 119 1 Further further JJ cord-104204-pdnkabwj 119 2 work work NN cord-104204-pdnkabwj 119 3 will will MD cord-104204-pdnkabwj 119 4 be be VB cord-104204-pdnkabwj 119 5 needed need VBN cord-104204-pdnkabwj 119 6 to to TO cord-104204-pdnkabwj 119 7 delineate delineate VB cord-104204-pdnkabwj 119 8 this this DT cord-104204-pdnkabwj 119 9 . . . cord-104204-pdnkabwj 120 1 The the DT cord-104204-pdnkabwj 120 2 hypothesis hypothesis NN cord-104204-pdnkabwj 120 3 emerging emerge VBG cord-104204-pdnkabwj 120 4 from from IN cord-104204-pdnkabwj 120 5 these these DT cord-104204-pdnkabwj 120 6 observations observation NNS cord-104204-pdnkabwj 120 7 is be VBZ cord-104204-pdnkabwj 120 8 that that IN cord-104204-pdnkabwj 120 9 groundwater groundwater NN cord-104204-pdnkabwj 120 10 leaches leach VBZ cord-104204-pdnkabwj 120 11 toxic toxic JJ cord-104204-pdnkabwj 120 12 organic organic JJ cord-104204-pdnkabwj 120 13 compounds compound NNS cord-104204-pdnkabwj 120 14 from from IN cord-104204-pdnkabwj 120 15 these these DT cord-104204-pdnkabwj 120 16 low low JJ cord-104204-pdnkabwj 120 17 rank rank NN cord-104204-pdnkabwj 120 18 coals coal NNS cord-104204-pdnkabwj 120 19 , , , cord-104204-pdnkabwj 120 20 with with IN cord-104204-pdnkabwj 120 21 subsequent subsequent JJ cord-104204-pdnkabwj 120 22 transportation transportation NN cord-104204-pdnkabwj 120 23 of of IN cord-104204-pdnkabwj 120 24 these these DT cord-104204-pdnkabwj 120 25 organics organic NNS cord-104204-pdnkabwj 120 26 to to IN cord-104204-pdnkabwj 120 27 wells well NNS cord-104204-pdnkabwj 120 28 in in IN cord-104204-pdnkabwj 120 29 the the DT cord-104204-pdnkabwj 120 30 alluvial alluvial JJ cord-104204-pdnkabwj 120 31 valleys valley NNS cord-104204-pdnkabwj 120 32 below below IN cord-104204-pdnkabwj 120 33 the the DT cord-104204-pdnkabwj 120 34 lignite lignite JJ cord-104204-pdnkabwj 120 35 deposits deposit NNS cord-104204-pdnkabwj 120 36 ( ( -LRB- cord-104204-pdnkabwj 120 37 29 29 CD cord-104204-pdnkabwj 120 38 , , , cord-104204-pdnkabwj 120 39 41 41 CD cord-104204-pdnkabwj 120 40 ) ) -RRB- cord-104204-pdnkabwj 121 1 ( ( -LRB- cord-104204-pdnkabwj 121 2 Fig Fig NNP cord-104204-pdnkabwj 121 3 . . NNP cord-104204-pdnkabwj 121 4 4 4 CD cord-104204-pdnkabwj 121 5 ) ) -RRB- cord-104204-pdnkabwj 121 6 . . . cord-104204-pdnkabwj 122 1 The the DT cord-104204-pdnkabwj 122 2 inhabitants inhabitant NNS cord-104204-pdnkabwj 122 3 of of IN cord-104204-pdnkabwj 122 4 the the DT cord-104204-pdnkabwj 122 5 rural rural JJ cord-104204-pdnkabwj 122 6 villages village NNS cord-104204-pdnkabwj 122 7 who who WP cord-104204-pdnkabwj 122 8 rely rely VBP cord-104204-pdnkabwj 122 9 on on IN cord-104204-pdnkabwj 122 10 well well JJ cord-104204-pdnkabwj 122 11 water water NN cord-104204-pdnkabwj 122 12 for for IN cord-104204-pdnkabwj 122 13 drinking drinking NN cord-104204-pdnkabwj 122 14 , , , cord-104204-pdnkabwj 122 15 cooking cooking NN cord-104204-pdnkabwj 122 16 , , , cord-104204-pdnkabwj 122 17 and and CC cord-104204-pdnkabwj 122 18 other other JJ cord-104204-pdnkabwj 122 19 purposes purpose NNS cord-104204-pdnkabwj 122 20 are be VBP cord-104204-pdnkabwj 122 21 thus thus RB cord-104204-pdnkabwj 122 22 exposed expose VBN cord-104204-pdnkabwj 122 23 to to IN cord-104204-pdnkabwj 122 24 these these DT cord-104204-pdnkabwj 122 25 toxic toxic JJ cord-104204-pdnkabwj 122 26 organics organic NNS cord-104204-pdnkabwj 122 27 for for IN cord-104204-pdnkabwj 122 28 long long JJ cord-104204-pdnkabwj 122 29 periods period NNS cord-104204-pdnkabwj 122 30 of of IN cord-104204-pdnkabwj 122 31 time time NN cord-104204-pdnkabwj 122 32 . . . cord-104204-pdnkabwj 123 1 Although although IN cord-104204-pdnkabwj 123 2 the the DT cord-104204-pdnkabwj 123 3 concentrations concentration NNS cord-104204-pdnkabwj 123 4 of of IN cord-104204-pdnkabwj 123 5 these these DT cord-104204-pdnkabwj 123 6 organic organic JJ cord-104204-pdnkabwj 123 7 molecules molecule NNS cord-104204-pdnkabwj 123 8 in in IN cord-104204-pdnkabwj 123 9 the the DT cord-104204-pdnkabwj 123 10 well well JJ cord-104204-pdnkabwj 123 11 water water NN cord-104204-pdnkabwj 123 12 may may MD cord-104204-pdnkabwj 123 13 be be VB cord-104204-pdnkabwj 123 14 low low JJ cord-104204-pdnkabwj 123 15 , , , cord-104204-pdnkabwj 123 16 long long JJ cord-104204-pdnkabwj 123 17 exposure exposure NN cord-104204-pdnkabwj 123 18 and/or and/or CC cord-104204-pdnkabwj 123 19 accumulation accumulation NN cord-104204-pdnkabwj 123 20 in in IN cord-104204-pdnkabwj 123 21 body body NN cord-104204-pdnkabwj 123 22 tissues tissue NNS cord-104204-pdnkabwj 123 23 over over IN cord-104204-pdnkabwj 123 24 time time NN cord-104204-pdnkabwj 123 25 may may MD cord-104204-pdnkabwj 123 26 lead lead VB cord-104204-pdnkabwj 123 27 to to IN cord-104204-pdnkabwj 123 28 kidney kidney NN cord-104204-pdnkabwj 123 29 lesions lesion NNS cord-104204-pdnkabwj 123 30 , , , cord-104204-pdnkabwj 123 31 the the DT cord-104204-pdnkabwj 123 32 development development NN cord-104204-pdnkabwj 123 33 of of IN cord-104204-pdnkabwj 123 34 urothelial urothelial JJ cord-104204-pdnkabwj 123 35 carcinomas carcinoma NNS cord-104204-pdnkabwj 123 36 in in IN cord-104204-pdnkabwj 123 37 some some DT cord-104204-pdnkabwj 123 38 individuals individual NNS cord-104204-pdnkabwj 123 39 , , , cord-104204-pdnkabwj 123 40 and and CC cord-104204-pdnkabwj 123 41 ultimately ultimately RB cord-104204-pdnkabwj 123 42 to to TO cord-104204-pdnkabwj 123 43 fill fill VB cord-104204-pdnkabwj 123 44 - - HYPH cord-104204-pdnkabwj 123 45 blown blow VBN cord-104204-pdnkabwj 123 46 BEN BEN NNP cord-104204-pdnkabwj 123 47 . . . cord-104204-pdnkabwj 124 1 Pliocene Pliocene NNP cord-104204-pdnkabwj 124 2 lignites lignite NNS cord-104204-pdnkabwj 124 3 are be VBP cord-104204-pdnkabwj 124 4 some some DT cord-104204-pdnkabwj 124 5 of of IN cord-104204-pdnkabwj 124 6 the the DT cord-104204-pdnkabwj 124 7 youngest young JJS cord-104204-pdnkabwj 124 8 coals coal NNS cord-104204-pdnkabwj 124 9 in in IN cord-104204-pdnkabwj 124 10 the the DT cord-104204-pdnkabwj 124 11 Balkans Balkans NNPS cord-104204-pdnkabwj 124 12 and and CC cord-104204-pdnkabwj 124 13 are be VBP cord-104204-pdnkabwj 124 14 relatively relatively RB cord-104204-pdnkabwj 124 15 unmetamorphosed unmetamorphosed JJ cord-104204-pdnkabwj 124 16 . . . cord-104204-pdnkabwj 125 1 As as IN cord-104204-pdnkabwj 125 2 such such JJ cord-104204-pdnkabwj 125 3 , , , cord-104204-pdnkabwj 125 4 they -PRON- PRP cord-104204-pdnkabwj 125 5 retain retain VBP cord-104204-pdnkabwj 125 6 many many JJ cord-104204-pdnkabwj 125 7 of of IN cord-104204-pdnkabwj 125 8 the the DT cord-104204-pdnkabwj 125 9 complex complex JJ cord-104204-pdnkabwj 125 10 organic organic JJ cord-104204-pdnkabwj 125 11 compounds compound NNS cord-104204-pdnkabwj 125 12 contained contain VBN cord-104204-pdnkabwj 125 13 in in IN cord-104204-pdnkabwj 125 14 their -PRON- PRP$ cord-104204-pdnkabwj 125 15 decaying decay VBG cord-104204-pdnkabwj 125 16 plant plant NN cord-104204-pdnkabwj 125 17 precursors precursor NNS cord-104204-pdnkabwj 125 18 , , , cord-104204-pdnkabwj 125 19 and and CC cord-104204-pdnkabwj 125 20 many many JJ cord-104204-pdnkabwj 125 21 kinds kind NNS cord-104204-pdnkabwj 125 22 of of IN cord-104204-pdnkabwj 125 23 potentially potentially RB cord-104204-pdnkabwj 125 24 toxic toxic JJ cord-104204-pdnkabwj 125 25 organic organic JJ cord-104204-pdnkabwj 125 26 compounds compound NNS cord-104204-pdnkabwj 125 27 may may MD cord-104204-pdnkabwj 125 28 be be VB cord-104204-pdnkabwj 125 29 leached leach VBN cord-104204-pdnkabwj 125 30 from from IN cord-104204-pdnkabwj 125 31 them -PRON- PRP cord-104204-pdnkabwj 125 32 ( ( -LRB- cord-104204-pdnkabwj 125 33 29 29 CD cord-104204-pdnkabwj 125 34 ) ) -RRB- cord-104204-pdnkabwj 125 35 . . . cord-104204-pdnkabwj 126 1 Semiquantitative Semiquantitative NNP cord-104204-pdnkabwj 126 2 analysis analysis NN cord-104204-pdnkabwj 126 3 of of IN cord-104204-pdnkabwj 126 4 shallow shallow JJ cord-104204-pdnkabwj 126 5 well well JJ cord-104204-pdnkabwj 126 6 water water NN cord-104204-pdnkabwj 126 7 from from IN cord-104204-pdnkabwj 126 8 endemic endemic JJ cord-104204-pdnkabwj 126 9 villages village NNS cord-104204-pdnkabwj 126 10 revealed reveal VBD cord-104204-pdnkabwj 126 11 the the DT cord-104204-pdnkabwj 126 12 presence presence NN cord-104204-pdnkabwj 126 13 of of IN cord-104204-pdnkabwj 126 14 PAHs pah NNS cord-104204-pdnkabwj 126 15 ( ( -LRB- cord-104204-pdnkabwj 126 16 pyrene pyrene NN cord-104204-pdnkabwj 126 17 , , , cord-104204-pdnkabwj 126 18 anthracene anthracene NN cord-104204-pdnkabwj 126 19 ) ) -RRB- cord-104204-pdnkabwj 126 20 and and CC cord-104204-pdnkabwj 126 21 aromatic aromatic JJ cord-104204-pdnkabwj 126 22 amines amine NNS cord-104204-pdnkabwj 126 23 ( ( -LRB- cord-104204-pdnkabwj 126 24 aniline aniline NN cord-104204-pdnkabwj 126 25 , , , cord-104204-pdnkabwj 126 26 naphtylamine naphtylamine NNP cord-104204-pdnkabwj 126 27 ) ) -RRB- cord-104204-pdnkabwj 126 28 . . . cord-104204-pdnkabwj 127 1 Some some DT cord-104204-pdnkabwj 127 2 PAHs pah NNS cord-104204-pdnkabwj 127 3 ( ( -LRB- cord-104204-pdnkabwj 127 4 e.g. e.g. RB cord-104204-pdnkabwj 127 5 , , , cord-104204-pdnkabwj 127 6 benzopyrene benzopyrene NNP cord-104204-pdnkabwj 127 7 , , , cord-104204-pdnkabwj 127 8 benzanthracene benzanthracene NNP cord-104204-pdnkabwj 127 9 , , , cord-104204-pdnkabwj 127 10 benzofluoranthene benzofluoranthene NNP cord-104204-pdnkabwj 127 11 ) ) -RRB- cord-104204-pdnkabwj 127 12 are be VBP cord-104204-pdnkabwj 127 13 known know VBN cord-104204-pdnkabwj 127 14 or or CC cord-104204-pdnkabwj 127 15 suspected suspect VBN cord-104204-pdnkabwj 127 16 carcinogens carcinogen NNS cord-104204-pdnkabwj 127 17 , , , cord-104204-pdnkabwj 127 18 and and CC cord-104204-pdnkabwj 127 19 aromatic aromatic JJ cord-104204-pdnkabwj 127 20 amines amine NNS cord-104204-pdnkabwj 127 21 have have VBP cord-104204-pdnkabwj 127 22 been be VBN cord-104204-pdnkabwj 127 23 linked link VBN cord-104204-pdnkabwj 127 24 to to IN cord-104204-pdnkabwj 127 25 urinary urinary JJ cord-104204-pdnkabwj 127 26 tract tract NN cord-104204-pdnkabwj 127 27 cancer cancer NN cord-104204-pdnkabwj 127 28 and and CC cord-104204-pdnkabwj 127 29 tubulointerstitial tubulointerstitial JJ cord-104204-pdnkabwj 127 30 nephropathies nephropathy NNS cord-104204-pdnkabwj 127 31 . . . cord-104204-pdnkabwj 128 1 Thus thus RB cord-104204-pdnkabwj 128 2 , , , cord-104204-pdnkabwj 128 3 long long JJ cord-104204-pdnkabwj 128 4 exposure exposure NN cord-104204-pdnkabwj 128 5 to to IN cord-104204-pdnkabwj 128 6 these these DT cord-104204-pdnkabwj 128 7 and/or and/or CC cord-104204-pdnkabwj 128 8 similar similar JJ cord-104204-pdnkabwj 128 9 compounds compound NNS cord-104204-pdnkabwj 128 10 in in IN cord-104204-pdnkabwj 128 11 well well JJ cord-104204-pdnkabwj 128 12 water water NN cord-104204-pdnkabwj 128 13 in in IN cord-104204-pdnkabwj 128 14 a a DT cord-104204-pdnkabwj 128 15 population population NN cord-104204-pdnkabwj 128 16 dependent dependent JJ cord-104204-pdnkabwj 128 17 on on IN cord-104204-pdnkabwj 128 18 this this DT cord-104204-pdnkabwj 128 19 source source NN cord-104204-pdnkabwj 128 20 ofwater ofwater NN cord-104204-pdnkabwj 128 21 could could MD cord-104204-pdnkabwj 128 22 be be VB cord-104204-pdnkabwj 128 23 linked link VBN cord-104204-pdnkabwj 128 24 to to IN cord-104204-pdnkabwj 128 25 BEN BEN NNP cord-104204-pdnkabwj 128 26 etiology etiology NN cord-104204-pdnkabwj 128 27 and and CC cord-104204-pdnkabwj 128 28 the the DT cord-104204-pdnkabwj 128 29 high high JJ cord-104204-pdnkabwj 128 30 incidence incidence NN cord-104204-pdnkabwj 128 31 of of IN cord-104204-pdnkabwj 128 32 urothelial urothelial JJ cord-104204-pdnkabwj 128 33 cancer cancer NN cord-104204-pdnkabwj 128 34 in in IN cord-104204-pdnkabwj 128 35 individuals individual NNS cord-104204-pdnkabwj 128 36 with with IN cord-104204-pdnkabwj 128 37 BEN BEN NNP cord-104204-pdnkabwj 128 38 . . . cord-104204-pdnkabwj 129 1 This this DT cord-104204-pdnkabwj 129 2 hypothesis hypothesis NN cord-104204-pdnkabwj 129 3 is be VBZ cord-104204-pdnkabwj 129 4 appealing appeal VBG cord-104204-pdnkabwj 129 5 in in IN cord-104204-pdnkabwj 129 6 that that IN cord-104204-pdnkabwj 129 7 it -PRON- PRP cord-104204-pdnkabwj 129 8 accounts account VBZ cord-104204-pdnkabwj 129 9 for for IN cord-104204-pdnkabwj 129 10 the the DT cord-104204-pdnkabwj 129 11 geographical geographical JJ cord-104204-pdnkabwj 129 12 restriction restriction NN cord-104204-pdnkabwj 129 13 as as RB cord-104204-pdnkabwj 129 14 well well RB cord-104204-pdnkabwj 129 15 as as IN cord-104204-pdnkabwj 129 16 for for IN cord-104204-pdnkabwj 129 17 the the DT cord-104204-pdnkabwj 129 18 epidemiological epidemiological JJ cord-104204-pdnkabwj 129 19 and and CC cord-104204-pdnkabwj 129 20 clinical clinical JJ cord-104204-pdnkabwj 129 21 features feature NNS cord-104204-pdnkabwj 129 22 of of IN cord-104204-pdnkabwj 129 23 BEN BEN NNP cord-104204-pdnkabwj 129 24 . . . cord-104204-pdnkabwj 130 1 Based base VBN cord-104204-pdnkabwj 130 2 on on IN cord-104204-pdnkabwj 130 3 the the DT cord-104204-pdnkabwj 130 4 present present JJ cord-104204-pdnkabwj 130 5 status status NN cord-104204-pdnkabwj 130 6 of of IN cord-104204-pdnkabwj 130 7 knowledge knowledge NN cord-104204-pdnkabwj 130 8 in in IN cord-104204-pdnkabwj 130 9 nephrotoxicology nephrotoxicology NN cord-104204-pdnkabwj 130 10 , , , cord-104204-pdnkabwj 130 11 however however RB cord-104204-pdnkabwj 130 12 , , , cord-104204-pdnkabwj 130 13 it -PRON- PRP cord-104204-pdnkabwj 130 14 should should MD cord-104204-pdnkabwj 130 15 be be VB cord-104204-pdnkabwj 130 16 noted note VBN cord-104204-pdnkabwj 130 17 that that IN cord-104204-pdnkabwj 130 18 the the DT cord-104204-pdnkabwj 130 19 currently currently RB cord-104204-pdnkabwj 130 20 observed observe VBN cord-104204-pdnkabwj 130 21 PAHs pah NNS cord-104204-pdnkabwj 130 22 and and CC cord-104204-pdnkabwj 130 23 aromatic aromatic JJ cord-104204-pdnkabwj 130 24 amines amine NNS cord-104204-pdnkabwj 130 25 in in IN cord-104204-pdnkabwj 130 26 the the DT cord-104204-pdnkabwj 130 27 well well JJ cord-104204-pdnkabwj 130 28 water water NN cord-104204-pdnkabwj 130 29 from from IN cord-104204-pdnkabwj 130 30 endemic endemic JJ cord-104204-pdnkabwj 130 31 villages village NNS cord-104204-pdnkabwj 130 32 are be VBP cord-104204-pdnkabwj 130 33 not not RB cord-104204-pdnkabwj 130 34 sufficient sufficient JJ cord-104204-pdnkabwj 130 35 to to TO cord-104204-pdnkabwj 130 36 explain explain VB cord-104204-pdnkabwj 130 37 the the DT cord-104204-pdnkabwj 130 38 tissue tissue NN cord-104204-pdnkabwj 130 39 ( ( -LRB- cord-104204-pdnkabwj 130 40 kidney)confined kidney)confined NNP cord-104204-pdnkabwj 130 41 toxicity toxicity NN cord-104204-pdnkabwj 130 42 in in IN cord-104204-pdnkabwj 130 43 BEN BEN NNP cord-104204-pdnkabwj 130 44 . . . cord-104204-pdnkabwj 131 1 More more RBR cord-104204-pdnkabwj 131 2 specific specific JJ cord-104204-pdnkabwj 131 3 ( ( -LRB- cord-104204-pdnkabwj 131 4 kidney kidney NN cord-104204-pdnkabwj 131 5 - - HYPH cord-104204-pdnkabwj 131 6 oriented orient VBN cord-104204-pdnkabwj 131 7 ) ) -RRB- cord-104204-pdnkabwj 131 8 toxic toxic JJ cord-104204-pdnkabwj 131 9 molecules molecule NNS cord-104204-pdnkabwj 131 10 present present JJ cord-104204-pdnkabwj 131 11 in in IN cord-104204-pdnkabwj 131 12 well well JJ cord-104204-pdnkabwj 131 13 water water NN cord-104204-pdnkabwj 131 14 and and CC cord-104204-pdnkabwj 131 15 derived derive VBN cord-104204-pdnkabwj 131 16 from from IN cord-104204-pdnkabwj 131 17 Pliocene Pliocene NNP cord-104204-pdnkabwj 131 18 lignites lignite NNS cord-104204-pdnkabwj 131 19 also also RB cord-104204-pdnkabwj 131 20 will will MD cord-104204-pdnkabwj 131 21 need need VB cord-104204-pdnkabwj 131 22 to to TO cord-104204-pdnkabwj 131 23 be be VB cord-104204-pdnkabwj 131 24 identified identify VBN cord-104204-pdnkabwj 131 25 to to TO cord-104204-pdnkabwj 131 26 further further RB cord-104204-pdnkabwj 131 27 validate validate VB cord-104204-pdnkabwj 131 28 this this DT cord-104204-pdnkabwj 131 29 hypothesis hypothesis NN cord-104204-pdnkabwj 131 30 . . . cord-104204-pdnkabwj 132 1 Many many JJ cord-104204-pdnkabwj 132 2 such such JJ cord-104204-pdnkabwj 132 3 compounds compound NNS cord-104204-pdnkabwj 132 4 may may MD cord-104204-pdnkabwj 132 5 indeed indeed RB cord-104204-pdnkabwj 132 6 be be VB cord-104204-pdnkabwj 132 7 present present JJ cord-104204-pdnkabwj 132 8 in in IN cord-104204-pdnkabwj 132 9 Pliocene Pliocene NNP cord-104204-pdnkabwj 132 10 lignites lignite NNS cord-104204-pdnkabwj 132 11 , , , cord-104204-pdnkabwj 132 12 given give VBN cord-104204-pdnkabwj 132 13 the the DT cord-104204-pdnkabwj 132 14 complex complex JJ cord-104204-pdnkabwj 132 15 organic organic JJ cord-104204-pdnkabwj 132 16 structure structure NN cord-104204-pdnkabwj 132 17 of of IN cord-104204-pdnkabwj 132 18 coal coal NN cord-104204-pdnkabwj 132 19 . . . cord-104204-pdnkabwj 133 1 On on IN cord-104204-pdnkabwj 133 2 the the DT cord-104204-pdnkabwj 133 3 other other JJ cord-104204-pdnkabwj 133 4 hand hand NN cord-104204-pdnkabwj 133 5 , , , cord-104204-pdnkabwj 133 6 BEN BEN NNP cord-104204-pdnkabwj 133 7 could could MD cord-104204-pdnkabwj 133 8 be be VB cord-104204-pdnkabwj 133 9 a a DT cord-104204-pdnkabwj 133 10 unique unique JJ cord-104204-pdnkabwj 133 11 experiment experiment NN cord-104204-pdnkabwj 133 12 of of IN cord-104204-pdnkabwj 133 13 nature nature NN cord-104204-pdnkabwj 133 14 , , , cord-104204-pdnkabwj 133 15 the the DT cord-104204-pdnkabwj 133 16 concentration concentration NN cord-104204-pdnkabwj 133 17 , , , cord-104204-pdnkabwj 133 18 the the DT cord-104204-pdnkabwj 133 19 route route NN cord-104204-pdnkabwj 133 20 of of IN cord-104204-pdnkabwj 133 21 entry entry NN cord-104204-pdnkabwj 133 22 , , , cord-104204-pdnkabwj 133 23 the the DT cord-104204-pdnkabwj 133 24 association association NN cord-104204-pdnkabwj 133 25 with with IN cord-104204-pdnkabwj 133 26 other other JJ cord-104204-pdnkabwj 133 27 nephrotoxic nephrotoxic NNP cord-104204-pdnkabwj 133 28 compounds compound NNS cord-104204-pdnkabwj 133 29 ( ( -LRB- cord-104204-pdnkabwj 133 30 such such JJ cord-104204-pdnkabwj 133 31 as as IN cord-104204-pdnkabwj 133 32 mycotoxins mycotoxin NNS cord-104204-pdnkabwj 133 33 ) ) -RRB- cord-104204-pdnkabwj 133 34 , , , cord-104204-pdnkabwj 133 35 and and CC cord-104204-pdnkabwj 133 36 the the DT cord-104204-pdnkabwj 133 37 intermittent intermittent JJ cord-104204-pdnkabwj 133 38 intake intake NN cord-104204-pdnkabwj 133 39 pattern pattern NN cord-104204-pdnkabwj 133 40 of of IN cord-104204-pdnkabwj 133 41 the the DT cord-104204-pdnkabwj 133 42 toxicant(s toxicant(s NNP cord-104204-pdnkabwj 133 43 ) ) -RRB- cord-104204-pdnkabwj 133 44 characterized characterize VBN cord-104204-pdnkabwj 133 45 by by IN cord-104204-pdnkabwj 133 46 seasonal seasonal JJ cord-104204-pdnkabwj 133 47 variations variation NNS cord-104204-pdnkabwj 133 48 , , , cord-104204-pdnkabwj 133 49 causing cause VBG cord-104204-pdnkabwj 133 50 some some DT cord-104204-pdnkabwj 133 51 simple simple JJ cord-104204-pdnkabwj 133 52 molecules molecule NNS cord-104204-pdnkabwj 133 53 such such JJ cord-104204-pdnkabwj 133 54 as as IN cord-104204-pdnkabwj 133 55 PAHs pah NNS cord-104204-pdnkabwj 133 56 to to TO cord-104204-pdnkabwj 133 57 be be VB cord-104204-pdnkabwj 133 58 specific specific JJ cord-104204-pdnkabwj 133 59 in in IN cord-104204-pdnkabwj 133 60 their -PRON- PRP$ cord-104204-pdnkabwj 133 61 target target NN cord-104204-pdnkabwj 133 62 tissue tissue NN cord-104204-pdnkabwj 133 63 action action NN cord-104204-pdnkabwj 133 64 , , , cord-104204-pdnkabwj 133 65 with with IN cord-104204-pdnkabwj 133 66 chronic chronic JJ cord-104204-pdnkabwj 133 67 nephrotoxicity nephrotoxicity NN cord-104204-pdnkabwj 133 68 and and CC cord-104204-pdnkabwj 133 69 slow slow JJ cord-104204-pdnkabwj 133 70 carcinogenic carcinogenic JJ cord-104204-pdnkabwj 133 71 activity activity NN cord-104204-pdnkabwj 133 72 as as IN cord-104204-pdnkabwj 133 73 their -PRON- PRP$ cord-104204-pdnkabwj 133 74 most most RBS cord-104204-pdnkabwj 133 75 salient salient JJ cord-104204-pdnkabwj 133 76 biological biological JJ cord-104204-pdnkabwj 133 77 effects effect NNS cord-104204-pdnkabwj 133 78 . . . cord-104204-pdnkabwj 134 1 Besides besides IN cord-104204-pdnkabwj 134 2 the the DT cord-104204-pdnkabwj 134 3 Balkans Balkans NNPS cord-104204-pdnkabwj 134 4 , , , cord-104204-pdnkabwj 134 5 Pliocene pliocene JJ cord-104204-pdnkabwj 134 6 lignite lignite NN cord-104204-pdnkabwj 134 7 deposits deposit NNS cord-104204-pdnkabwj 134 8 are be VBP cord-104204-pdnkabwj 134 9 also also RB cord-104204-pdnkabwj 134 10 found find VBN cord-104204-pdnkabwj 134 11 in in IN cord-104204-pdnkabwj 134 12 Italy Italy NNP cord-104204-pdnkabwj 134 13 , , , cord-104204-pdnkabwj 134 14 Turkey Turkey NNP cord-104204-pdnkabwj 134 15 , , , cord-104204-pdnkabwj 134 16 Greece Greece NNP cord-104204-pdnkabwj 134 17 , , , cord-104204-pdnkabwj 134 18 and and CC cord-104204-pdnkabwj 134 19 Myanmar Myanmar NNP cord-104204-pdnkabwj 134 20 . . . cord-104204-pdnkabwj 135 1 Also also RB cord-104204-pdnkabwj 135 2 , , , cord-104204-pdnkabwj 135 3 low low JJ cord-104204-pdnkabwj 135 4 rank rank NN cord-104204-pdnkabwj 135 5 , , , cord-104204-pdnkabwj 135 6 highly highly RB cord-104204-pdnkabwj 135 7 unaltered unaltered JJ cord-104204-pdnkabwj 135 8 coals coal NNS cord-104204-pdnkabwj 135 9 such such JJ cord-104204-pdnkabwj 135 10 as as IN cord-104204-pdnkabwj 135 11 the the DT cord-104204-pdnkabwj 135 12 Pliocene Pliocene NNP cord-104204-pdnkabwj 135 13 lignites lignite NNS cord-104204-pdnkabwj 135 14 from from IN cord-104204-pdnkabwj 135 15 the the DT cord-104204-pdnkabwj 135 16 Balkans Balkans NNPS cord-104204-pdnkabwj 135 17 are be VBP cord-104204-pdnkabwj 135 18 distributed distribute VBN cord-104204-pdnkabwj 135 19 worldwide worldwide RB cord-104204-pdnkabwj 135 20 ( ( -LRB- cord-104204-pdnkabwj 135 21 e.g. e.g. RB cord-104204-pdnkabwj 135 22 , , , cord-104204-pdnkabwj 135 23 Australian australian JJ cord-104204-pdnkabwj 135 24 brown brown JJ cord-104204-pdnkabwj 135 25 coals coal NNS cord-104204-pdnkabwj 135 26 , , , cord-104204-pdnkabwj 135 27 North North NNP cord-104204-pdnkabwj 135 28 Dakota Dakota NNP cord-104204-pdnkabwj 135 29 and and CC cord-104204-pdnkabwj 135 30 Gulf Gulf NNP cord-104204-pdnkabwj 135 31 Coast Coast NNP cord-104204-pdnkabwj 135 32 lignites lignite NNS cord-104204-pdnkabwj 135 33 , , , cord-104204-pdnkabwj 135 34 Chinese chinese JJ cord-104204-pdnkabwj 135 35 lignites lignite NNS cord-104204-pdnkabwj 135 36 , , , cord-104204-pdnkabwj 135 37 etc etc FW cord-104204-pdnkabwj 135 38 . . . cord-104204-pdnkabwj 135 39 ) ) -RRB- cord-104204-pdnkabwj 135 40 . . . cord-104204-pdnkabwj 136 1 However however RB cord-104204-pdnkabwj 136 2 , , , cord-104204-pdnkabwj 136 3 in in IN cord-104204-pdnkabwj 136 4 the the DT cord-104204-pdnkabwj 136 5 Pliocene Pliocene NNP cord-104204-pdnkabwj 136 6 lignite lignite NN cord-104204-pdnkabwj 136 7 hypothesis hypothesis NN cord-104204-pdnkabwj 136 8 of of IN cord-104204-pdnkabwj 136 9 BEN BEN NNP cord-104204-pdnkabwj 136 10 etiology etiology NN cord-104204-pdnkabwj 136 11 , , , cord-104204-pdnkabwj 136 12 other other JJ cord-104204-pdnkabwj 136 13 factors factor NNS cord-104204-pdnkabwj 136 14 besides besides IN cord-104204-pdnkabwj 136 15 the the DT cord-104204-pdnkabwj 136 16 presence presence NN cord-104204-pdnkabwj 136 17 of of IN cord-104204-pdnkabwj 136 18 low low JJ cord-104204-pdnkabwj 136 19 rank rank NN cord-104204-pdnkabwj 136 20 coals coal NNS cord-104204-pdnkabwj 136 21 must must MD cord-104204-pdnkabwj 136 22 also also RB cord-104204-pdnkabwj 136 23 be be VB cord-104204-pdnkabwj 136 24 in in IN cord-104204-pdnkabwj 136 25 play play NN cord-104204-pdnkabwj 136 26 . . . cord-104204-pdnkabwj 137 1 The the DT cord-104204-pdnkabwj 137 2 hypothesis hypothesis NN cord-104204-pdnkabwj 137 3 also also RB cord-104204-pdnkabwj 137 4 implies imply VBZ cord-104204-pdnkabwj 137 5 many many JJ cord-104204-pdnkabwj 137 6 or or CC cord-104204-pdnkabwj 137 7 all all DT cord-104204-pdnkabwj 137 8 of of IN cord-104204-pdnkabwj 137 9 the the DT cord-104204-pdnkabwj 137 10 following follow VBG cord-104204-pdnkabwj 137 11 circumstances circumstance NNS cord-104204-pdnkabwj 137 12 : : : cord-104204-pdnkabwj 137 13 the the DT cord-104204-pdnkabwj 137 14 right right JJ cord-104204-pdnkabwj 137 15 hydrologic hydrologic JJ cord-104204-pdnkabwj 137 16 conditions condition NNS cord-104204-pdnkabwj 137 17 for for IN cord-104204-pdnkabwj 137 18 leaching leaching NN cord-104204-pdnkabwj 137 19 and and CC cord-104204-pdnkabwj 137 20 transport transport NN cord-104204-pdnkabwj 137 21 of of IN cord-104204-pdnkabwj 137 22 the the DT cord-104204-pdnkabwj 137 23 toxic toxic JJ cord-104204-pdnkabwj 137 24 organic organic JJ cord-104204-pdnkabwj 137 25 compounds compound NNS cord-104204-pdnkabwj 137 26 from from IN cord-104204-pdnkabwj 137 27 the the DT cord-104204-pdnkabwj 137 28 coal coal NN cord-104204-pdnkabwj 137 29 to to IN cord-104204-pdnkabwj 137 30 the the DT cord-104204-pdnkabwj 137 31 wells well NNS cord-104204-pdnkabwj 137 32 ; ; : cord-104204-pdnkabwj 137 33 a a DT cord-104204-pdnkabwj 137 34 rural rural JJ cord-104204-pdnkabwj 137 35 population population NN cord-104204-pdnkabwj 137 36 largely largely RB cord-104204-pdnkabwj 137 37 dependent dependent JJ cord-104204-pdnkabwj 137 38 on on IN cord-104204-pdnkabwj 137 39 untreated untreated JJ cord-104204-pdnkabwj 137 40 well well JJ cord-104204-pdnkabwj 137 41 water water NN cord-104204-pdnkabwj 137 42 ; ; : cord-104204-pdnkabwj 137 43 a a DT cord-104204-pdnkabwj 137 44 population population NN cord-104204-pdnkabwj 137 45 with with IN cord-104204-pdnkabwj 137 46 a a DT cord-104204-pdnkabwj 137 47 relatively relatively RB cord-104204-pdnkabwj 137 48 long long JJ cord-104204-pdnkabwj 137 49 lifespan lifespan NN cord-104204-pdnkabwj 137 50 ( ( -LRB- cord-104204-pdnkabwj 137 51 BEN BEN NNP cord-104204-pdnkabwj 137 52 commonly commonly RB cord-104204-pdnkabwj 137 53 becomes become VBZ cord-104204-pdnkabwj 137 54 manifest manifest NN cord-104204-pdnkabwj 137 55 in in IN cord-104204-pdnkabwj 137 56 people people NNS cord-104204-pdnkabwj 137 57 in in IN cord-104204-pdnkabwj 137 58 their -PRON- PRP$ cord-104204-pdnkabwj 137 59 40s 40 NNS cord-104204-pdnkabwj 137 60 and and CC cord-104204-pdnkabwj 137 61 50s 50 NNS cord-104204-pdnkabwj 137 62 ) ) -RRB- cord-104204-pdnkabwj 137 63 ; ; : cord-104204-pdnkabwj 137 64 a a DT cord-104204-pdnkabwj 137 65 relatively relatively RB cord-104204-pdnkabwj 137 66 settled settle VBN cord-104204-pdnkabwj 137 67 population population NN cord-104204-pdnkabwj 137 68 for for IN cord-104204-pdnkabwj 137 69 long long JJ cord-104204-pdnkabwj 137 70 exposure exposure NN cord-104204-pdnkabwj 137 71 to to IN cord-104204-pdnkabwj 137 72 the the DT cord-104204-pdnkabwj 137 73 source source NN cord-104204-pdnkabwj 137 74 of of IN cord-104204-pdnkabwj 137 75 nephrotoxic nephrotoxic JJ cord-104204-pdnkabwj 137 76 / / SYM cord-104204-pdnkabwj 137 77 carcinogenic carcinogenic JJ cord-104204-pdnkabwj 137 78 substances substance NNS cord-104204-pdnkabwj 137 79 ; ; : cord-104204-pdnkabwj 137 80 and and CC cord-104204-pdnkabwj 137 81 a a DT cord-104204-pdnkabwj 137 82 former former JJ cord-104204-pdnkabwj 137 83 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 137 84 and and CC cord-104204-pdnkabwj 137 85 Bulgaria Bulgaria NNP cord-104204-pdnkabwj 137 86 . . . cord-104204-pdnkabwj 138 1 Results result NNS cord-104204-pdnkabwj 138 2 were be VBD cord-104204-pdnkabwj 138 3 presented present VBN cord-104204-pdnkabwj 138 4 as as IN cord-104204-pdnkabwj 138 5 fluorescence fluorescence NN cord-104204-pdnkabwj 138 6 excitation excitation NN cord-104204-pdnkabwj 138 7 / / SYM cord-104204-pdnkabwj 138 8 emission emission NN cord-104204-pdnkabwj 138 9 matrix matrix NN cord-104204-pdnkabwj 138 10 spectral spectral JJ cord-104204-pdnkabwj 138 11 plots plot NNS cord-104204-pdnkabwj 138 12 , , , cord-104204-pdnkabwj 138 13 providing provide VBG cord-104204-pdnkabwj 138 14 gross gross JJ cord-104204-pdnkabwj 138 15 chemical chemical JJ cord-104204-pdnkabwj 138 16 characterization characterization NN cord-104204-pdnkabwj 138 17 of of IN cord-104204-pdnkabwj 138 18 the the DT cord-104204-pdnkabwj 138 19 organic organic JJ cord-104204-pdnkabwj 138 20 matter matter NN cord-104204-pdnkabwj 138 21 present present JJ cord-104204-pdnkabwj 138 22 in in IN cord-104204-pdnkabwj 138 23 the the DT cord-104204-pdnkabwj 138 24 water water NN cord-104204-pdnkabwj 138 25 samples sample NNS cord-104204-pdnkabwj 138 26 . . . cord-104204-pdnkabwj 139 1 Water water NN cord-104204-pdnkabwj 139 2 samples sample NNS cord-104204-pdnkabwj 139 3 from from IN cord-104204-pdnkabwj 139 4 BEN BEN NNP cord-104204-pdnkabwj 139 5 households household NNS cord-104204-pdnkabwj 139 6 in in IN cord-104204-pdnkabwj 139 7 endemic endemic JJ cord-104204-pdnkabwj 139 8 villages village NNS cord-104204-pdnkabwj 139 9 had have VBD cord-104204-pdnkabwj 139 10 distinctive distinctive JJ cord-104204-pdnkabwj 139 11 EEM EEM NNP cord-104204-pdnkabwj 139 12 matrix matrix NN cord-104204-pdnkabwj 139 13 spectra spectrum NNS cord-104204-pdnkabwj 139 14 , , , cord-104204-pdnkabwj 139 15 different different JJ cord-104204-pdnkabwj 139 16 from from IN cord-104204-pdnkabwj 139 17 those those DT cord-104204-pdnkabwj 139 18 of of IN cord-104204-pdnkabwj 139 19 water water NN cord-104204-pdnkabwj 139 20 samples sample NNS cord-104204-pdnkabwj 139 21 from from IN cord-104204-pdnkabwj 139 22 nonendemic nonendemic NNP cord-104204-pdnkabwj 139 23 villages village NNS cord-104204-pdnkabwj 139 24 . . . cord-104204-pdnkabwj 140 1 For for IN cord-104204-pdnkabwj 140 2 example example NN cord-104204-pdnkabwj 140 3 , , , cord-104204-pdnkabwj 140 4 water water NN cord-104204-pdnkabwj 140 5 samples sample NNS cord-104204-pdnkabwj 140 6 from from IN cord-104204-pdnkabwj 140 7 endemic endemic JJ cord-104204-pdnkabwj 140 8 villages village NNS cord-104204-pdnkabwj 140 9 had have VBD cord-104204-pdnkabwj 140 10 distinctive distinctive JJ cord-104204-pdnkabwj 140 11 teardrop teardrop NN cord-104204-pdnkabwj 140 12 - - HYPH cord-104204-pdnkabwj 140 13 shaped shape VBN cord-104204-pdnkabwj 140 14 EEM EEM NNP cord-104204-pdnkabwj 140 15 matrix matrix NN cord-104204-pdnkabwj 140 16 spectra spectrum NNS cord-104204-pdnkabwj 140 17 , , , cord-104204-pdnkabwj 140 18 with with IN cord-104204-pdnkabwj 140 19 excitation excitation NN cord-104204-pdnkabwj 140 20 peaks peak NNS cord-104204-pdnkabwj 140 21 at at IN cord-104204-pdnkabwj 140 22 250 250 CD cord-104204-pdnkabwj 140 23 nm nm NN cord-104204-pdnkabwj 140 24 and and CC cord-104204-pdnkabwj 140 25 350 350 CD cord-104204-pdnkabwj 140 26 nm nm NN cord-104204-pdnkabwj 140 27 and and CC cord-104204-pdnkabwj 140 28 an an DT cord-104204-pdnkabwj 140 29 emission emission NN cord-104204-pdnkabwj 140 30 peak peak NN cord-104204-pdnkabwj 140 31 at at IN cord-104204-pdnkabwj 140 32 400 400 CD cord-104204-pdnkabwj 140 33 nm nm NN cord-104204-pdnkabwj 140 34 . . . cord-104204-pdnkabwj 141 1 In in IN cord-104204-pdnkabwj 141 2 contrast contrast NN cord-104204-pdnkabwj 141 3 , , , cord-104204-pdnkabwj 141 4 water water NN cord-104204-pdnkabwj 141 5 samples sample NNS cord-104204-pdnkabwj 141 6 from from IN cord-104204-pdnkabwj 141 7 the the DT cord-104204-pdnkabwj 141 8 nonendemic nonendemic NNP cord-104204-pdnkabwj 141 9 areas area NNS cord-104204-pdnkabwj 141 10 had have VBD cord-104204-pdnkabwj 141 11 EEM EEM NNP cord-104204-pdnkabwj 141 12 matrix matrix NN cord-104204-pdnkabwj 141 13 spectra spectrum NNS cord-104204-pdnkabwj 141 14 that that WDT cord-104204-pdnkabwj 141 15 lacked lack VBD cord-104204-pdnkabwj 141 16 the the DT cord-104204-pdnkabwj 141 17 teardrop teardrop NN cord-104204-pdnkabwj 141 18 shape shape NN cord-104204-pdnkabwj 141 19 and and CC cord-104204-pdnkabwj 141 20 the the DT cord-104204-pdnkabwj 141 21 250-nm 250-nm CD cord-104204-pdnkabwj 141 22 excitation excitation NN cord-104204-pdnkabwj 141 23 maximum maximum JJ cord-104204-pdnkabwj 141 24 characteristic characteristic NN cord-104204-pdnkabwj 141 25 of of IN cord-104204-pdnkabwj 141 26 endemic endemic JJ cord-104204-pdnkabwj 141 27 villages village NNS cord-104204-pdnkabwj 141 28 , , , cord-104204-pdnkabwj 141 29 and and CC cord-104204-pdnkabwj 141 30 had have VBD cord-104204-pdnkabwj 141 31 litde litde NNP cord-104204-pdnkabwj 141 32 fluorophoric fluorophoric NNP cord-104204-pdnkabwj 141 33 activity activity NN cord-104204-pdnkabwj 141 34 in in IN cord-104204-pdnkabwj 141 35 general general JJ cord-104204-pdnkabwj 141 36 . . . cord-104204-pdnkabwj 142 1 The the DT cord-104204-pdnkabwj 142 2 EEM EEM NNP cord-104204-pdnkabwj 142 3 matrix matrix NN cord-104204-pdnkabwj 142 4 spectra spectrum NNS cord-104204-pdnkabwj 142 5 of of IN cord-104204-pdnkabwj 142 6 well well JJ cord-104204-pdnkabwj 142 7 water water NN cord-104204-pdnkabwj 142 8 samples sample NNS cord-104204-pdnkabwj 142 9 from from IN cord-104204-pdnkabwj 142 10 endemic endemic JJ cord-104204-pdnkabwj 142 11 villages village NNS cord-104204-pdnkabwj 142 12 but but CC cord-104204-pdnkabwj 142 13 from from IN cord-104204-pdnkabwj 142 14 households household NNS cord-104204-pdnkabwj 142 15 not not RB cord-104204-pdnkabwj 142 16 affected affect VBN cord-104204-pdnkabwj 142 17 by by IN cord-104204-pdnkabwj 142 18 BEN BEN NNP cord-104204-pdnkabwj 142 19 had have VBD cord-104204-pdnkabwj 142 20 characteristics characteristic NNS cord-104204-pdnkabwj 142 21 similar similar JJ cord-104204-pdnkabwj 142 22 to to IN cord-104204-pdnkabwj 142 23 those those DT cord-104204-pdnkabwj 142 24 of of IN cord-104204-pdnkabwj 142 25 BEN BEN NNP cord-104204-pdnkabwj 142 26 - - HYPH cord-104204-pdnkabwj 142 27 afflicted afflict VBN cord-104204-pdnkabwj 142 28 households household NNS cord-104204-pdnkabwj 142 29 , , , cord-104204-pdnkabwj 142 30 but but CC cord-104204-pdnkabwj 142 31 fluorophoric fluorophoric JJ cord-104204-pdnkabwj 142 32 activity activity NN cord-104204-pdnkabwj 142 33 in in IN cord-104204-pdnkabwj 142 34 the the DT cord-104204-pdnkabwj 142 35 non non JJ cord-104204-pdnkabwj 142 36 - - JJ cord-104204-pdnkabwj 142 37 BEN BEN NNP cord-104204-pdnkabwj 142 38 households household NNS cord-104204-pdnkabwj 142 39 was be VBD cord-104204-pdnkabwj 142 40 considerably considerably RB cord-104204-pdnkabwj 142 41 lower low JJR cord-104204-pdnkabwj 143 1 ( ( -LRB- cord-104204-pdnkabwj 143 2 Fig Fig NNP cord-104204-pdnkabwj 143 3 . . NNP cord-104204-pdnkabwj 143 4 5 5 CD cord-104204-pdnkabwj 143 5 ) ) -RRB- cord-104204-pdnkabwj 143 6 . . . cord-104204-pdnkabwj 144 1 These these DT cord-104204-pdnkabwj 144 2 results result NNS cord-104204-pdnkabwj 144 3 showed show VBD cord-104204-pdnkabwj 144 4 significant significant JJ cord-104204-pdnkabwj 144 5 differences difference NNS cord-104204-pdnkabwj 144 6 between between IN cord-104204-pdnkabwj 144 7 the the DT cord-104204-pdnkabwj 144 8 dissolved dissolve VBN cord-104204-pdnkabwj 144 9 organic organic JJ cord-104204-pdnkabwj 144 10 constituents constituent NNS cord-104204-pdnkabwj 144 11 in in IN cord-104204-pdnkabwj 144 12 well well JJ cord-104204-pdnkabwj 144 13 water water NN cord-104204-pdnkabwj 144 14 from from IN cord-104204-pdnkabwj 144 15 endemic endemic JJ cord-104204-pdnkabwj 144 16 and and CC cord-104204-pdnkabwj 144 17 nonendemic nonendemic JJ cord-104204-pdnkabwj 144 18 areas area NNS cord-104204-pdnkabwj 144 19 of of IN cord-104204-pdnkabwj 144 20 the the DT cord-104204-pdnkabwj 144 21 Balkans Balkans NNPS cord-104204-pdnkabwj 144 22 , , , cord-104204-pdnkabwj 144 23 with with IN cord-104204-pdnkabwj 144 24 endemic endemic JJ cord-104204-pdnkabwj 144 25 areas area NNS cord-104204-pdnkabwj 144 26 exhibiting exhibit VBG cord-104204-pdnkabwj 144 27 far far RB cord-104204-pdnkabwj 144 28 greater great JJR cord-104204-pdnkabwj 144 29 fluorophoric fluorophoric JJ cord-104204-pdnkabwj 144 30 activity activity NN cord-104204-pdnkabwj 144 31 . . . cord-104204-pdnkabwj 145 1 Also also RB cord-104204-pdnkabwj 145 2 , , , cord-104204-pdnkabwj 145 3 well well UH cord-104204-pdnkabwj 145 4 water water NN cord-104204-pdnkabwj 145 5 from from IN cord-104204-pdnkabwj 145 6 BEN BEN NNP cord-104204-pdnkabwj 145 7 households household NNS cord-104204-pdnkabwj 145 8 appeared appear VBD cord-104204-pdnkabwj 145 9 to to TO cord-104204-pdnkabwj 145 10 have have VB cord-104204-pdnkabwj 145 11 higher high JJR cord-104204-pdnkabwj 145 12 concentrations concentration NNS cord-104204-pdnkabwj 145 13 of of IN cord-104204-pdnkabwj 145 14 these these DT cord-104204-pdnkabwj 145 15 fluorophoric fluorophoric JJ cord-104204-pdnkabwj 145 16 compounds compound NNS cord-104204-pdnkabwj 145 17 compared compare VBN cord-104204-pdnkabwj 145 18 to to IN cord-104204-pdnkabwj 145 19 non non JJ cord-104204-pdnkabwj 145 20 - - JJ cord-104204-pdnkabwj 145 21 BEN BEN NNP cord-104204-pdnkabwj 145 22 households household NNS cord-104204-pdnkabwj 145 23 from from IN cord-104204-pdnkabwj 145 24 endemic endemic JJ cord-104204-pdnkabwj 145 25 villages village NNS cord-104204-pdnkabwj 145 26 . . . cord-104204-pdnkabwj 146 1 Based base VBN cord-104204-pdnkabwj 146 2 on on IN cord-104204-pdnkabwj 146 3 these these DT cord-104204-pdnkabwj 146 4 data datum NNS cord-104204-pdnkabwj 146 5 , , , cord-104204-pdnkabwj 146 6 one one PRP cord-104204-pdnkabwj 146 7 could could MD cord-104204-pdnkabwj 146 8 hypothesize hypothesize VB cord-104204-pdnkabwj 146 9 that that IN cord-104204-pdnkabwj 146 10 toxic toxic JJ cord-104204-pdnkabwj 146 11 dissolved dissolve VBN cord-104204-pdnkabwj 146 12 organic organic JJ cord-104204-pdnkabwj 146 13 compounds compound NNS cord-104204-pdnkabwj 146 14 present present JJ cord-104204-pdnkabwj 146 15 in in IN cord-104204-pdnkabwj 146 16 the the DT cord-104204-pdnkabwj 146 17 well well JJ cord-104204-pdnkabwj 146 18 water water NN cord-104204-pdnkabwj 146 19 contribute contribute VB cord-104204-pdnkabwj 146 20 to to IN cord-104204-pdnkabwj 146 21 the the DT cord-104204-pdnkabwj 146 22 onset onset NN cord-104204-pdnkabwj 146 23 and and CC cord-104204-pdnkabwj 146 24 progression progression NN cord-104204-pdnkabwj 146 25 of of IN cord-104204-pdnkabwj 146 26 BEN BEN NNP cord-104204-pdnkabwj 146 27 . . . cord-104204-pdnkabwj 147 1 Well well UH cord-104204-pdnkabwj 147 2 water water NN cord-104204-pdnkabwj 147 3 from from IN cord-104204-pdnkabwj 147 4 households household NNS cord-104204-pdnkabwj 147 5 from from IN cord-104204-pdnkabwj 147 6 nonendemic nonendemic NNP cord-104204-pdnkabwj 147 7 villages village NNS cord-104204-pdnkabwj 147 8 appeared appear VBD cord-104204-pdnkabwj 147 9 to to TO cord-104204-pdnkabwj 147 10 lack lack VB cord-104204-pdnkabwj 147 11 the the DT cord-104204-pdnkabwj 147 12 specific specific JJ cord-104204-pdnkabwj 147 13 types type NNS cord-104204-pdnkabwj 147 14 of of IN cord-104204-pdnkabwj 147 15 organic organic JJ cord-104204-pdnkabwj 147 16 fluorophoric fluorophoric NNP cord-104204-pdnkabwj 147 17 compounds compound NNS cord-104204-pdnkabwj 147 18 observed observe VBN cord-104204-pdnkabwj 147 19 in in IN cord-104204-pdnkabwj 147 20 endemic endemic JJ cord-104204-pdnkabwj 147 21 villages village NNS cord-104204-pdnkabwj 147 22 , , , cord-104204-pdnkabwj 147 23 and and CC cord-104204-pdnkabwj 147 24 water water NN cord-104204-pdnkabwj 147 25 samples sample NNS cord-104204-pdnkabwj 147 26 from from IN cord-104204-pdnkabwj 147 27 non non JJ cord-104204-pdnkabwj 147 28 - - JJ cord-104204-pdnkabwj 147 29 BEN BEN NNP cord-104204-pdnkabwj 147 30 households household NNS cord-104204-pdnkabwj 147 31 from from IN cord-104204-pdnkabwj 147 32 endemic endemic JJ cord-104204-pdnkabwj 147 33 villages village NNS cord-104204-pdnkabwj 147 34 had have VBD cord-104204-pdnkabwj 147 35 these these DT cord-104204-pdnkabwj 147 36 fluorophoric fluorophoric JJ cord-104204-pdnkabwj 147 37 compounds compound NNS cord-104204-pdnkabwj 147 38 at at IN cord-104204-pdnkabwj 147 39 much much RB cord-104204-pdnkabwj 147 40 lower low JJR cord-104204-pdnkabwj 147 41 concentrations concentration NNS cord-104204-pdnkabwj 147 42 compared compare VBN cord-104204-pdnkabwj 147 43 to to IN cord-104204-pdnkabwj 147 44 BEN BEN NNP cord-104204-pdnkabwj 147 45 households household NNS cord-104204-pdnkabwj 147 46 . . . cord-104204-pdnkabwj 148 1 The the DT cord-104204-pdnkabwj 148 2 specific specific JJ cord-104204-pdnkabwj 148 3 nature nature NN cord-104204-pdnkabwj 148 4 of of IN cord-104204-pdnkabwj 148 5 the the DT cord-104204-pdnkabwj 148 6 fluorophoric fluorophoric NNP cord-104204-pdnkabwj 148 7 dissolved dissolve VBN cord-104204-pdnkabwj 148 8 organic organic JJ cord-104204-pdnkabwj 148 9 compounds compound NNS cord-104204-pdnkabwj 148 10 present present JJ cord-104204-pdnkabwj 148 11 in in IN cord-104204-pdnkabwj 148 12 the the DT cord-104204-pdnkabwj 148 13 well well JJ cord-104204-pdnkabwj 148 14 water water NN cord-104204-pdnkabwj 148 15 samples sample NNS cord-104204-pdnkabwj 148 16 from from IN cord-104204-pdnkabwj 148 17 endemic endemic JJ cord-104204-pdnkabwj 148 18 villages village NNS cord-104204-pdnkabwj 148 19 is be VBZ cord-104204-pdnkabwj 148 20 beyond beyond IN cord-104204-pdnkabwj 148 21 the the DT cord-104204-pdnkabwj 148 22 scope scope NN cord-104204-pdnkabwj 148 23 of of IN cord-104204-pdnkabwj 148 24 this this DT cord-104204-pdnkabwj 148 25 study study NN cord-104204-pdnkabwj 148 26 , , , cord-104204-pdnkabwj 148 27 but but CC cord-104204-pdnkabwj 148 28 aromatic aromatic JJ cord-104204-pdnkabwj 148 29 compounds compound NNS cord-104204-pdnkabwj 148 30 of of IN cord-104204-pdnkabwj 148 31 less less JJR cord-104204-pdnkabwj 148 32 than than IN cord-104204-pdnkabwj 148 33 600 600 CD cord-104204-pdnkabwj 148 34 daltons dalton NNS cord-104204-pdnkabwj 148 35 molecular molecular JJ cord-104204-pdnkabwj 148 36 weight weight NN cord-104204-pdnkabwj 148 37 are be VBP cord-104204-pdnkabwj 148 38 consistent consistent JJ cord-104204-pdnkabwj 148 39 with with IN cord-104204-pdnkabwj 148 40 the the DT cord-104204-pdnkabwj 148 41 data datum NNS cord-104204-pdnkabwj 148 42 . . . cord-104204-pdnkabwj 149 1 Additional additional JJ cord-104204-pdnkabwj 149 2 work work NN cord-104204-pdnkabwj 149 3 was be VBD cord-104204-pdnkabwj 149 4 performed perform VBN cord-104204-pdnkabwj 149 5 on on IN cord-104204-pdnkabwj 149 6 the the DT cord-104204-pdnkabwj 149 7 Pliocene Pliocene NNP cord-104204-pdnkabwj 149 8 lignite lignite NN cord-104204-pdnkabwj 149 9 hypothesis hypothesis NN cord-104204-pdnkabwj 149 10 in in IN cord-104204-pdnkabwj 149 11 1993 1993 CD cord-104204-pdnkabwj 150 1 ( ( -LRB- cord-104204-pdnkabwj 150 2 Orem Orem NNP cord-104204-pdnkabwj 150 3 et et NNP cord-104204-pdnkabwj 150 4 al al NNP cord-104204-pdnkabwj 150 5 . . NNP cord-104204-pdnkabwj 150 6 , , , cord-104204-pdnkabwj 150 7 unpublished unpublished JJ cord-104204-pdnkabwj 150 8 data datum NNS cord-104204-pdnkabwj 150 9 ) ) -RRB- cord-104204-pdnkabwj 151 1 to to TO cord-104204-pdnkabwj 151 2 examine examine VB cord-104204-pdnkabwj 151 3 1 1 CD cord-104204-pdnkabwj 151 4 ) ) -RRB- cord-104204-pdnkabwj 151 5 the the DT cord-104204-pdnkabwj 151 6 chemical chemical JJ cord-104204-pdnkabwj 151 7 structure structure NN cord-104204-pdnkabwj 151 8 of of IN cord-104204-pdnkabwj 151 9 Pliocene Pliocene NNP cord-104204-pdnkabwj 151 10 lignites lignite NNS cord-104204-pdnkabwj 151 11 from from IN cord-104204-pdnkabwj 151 12 the the DT cord-104204-pdnkabwj 151 13 endemic endemic JJ cord-104204-pdnkabwj 151 14 areas area NNS cord-104204-pdnkabwj 151 15 in in IN cord-104204-pdnkabwj 151 16 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 151 17 ; ; : cord-104204-pdnkabwj 151 18 2 2 CD cord-104204-pdnkabwj 151 19 ) ) -RRB- cord-104204-pdnkabwj 151 20 to to TO cord-104204-pdnkabwj 151 21 conduct conduct VB cord-104204-pdnkabwj 151 22 laboratory laboratory NN cord-104204-pdnkabwj 151 23 leaching leach VBG cord-104204-pdnkabwj 151 24 experiments experiment NNS cord-104204-pdnkabwj 151 25 on on IN cord-104204-pdnkabwj 151 26 these these DT cord-104204-pdnkabwj 151 27 coals coal NNS cord-104204-pdnkabwj 151 28 ; ; : cord-104204-pdnkabwj 151 29 and and CC cord-104204-pdnkabwj 151 30 3 3 LS cord-104204-pdnkabwj 151 31 ) ) -RRB- cord-104204-pdnkabwj 151 32 to to TO cord-104204-pdnkabwj 151 33 determine determine VB cord-104204-pdnkabwj 151 34 the the DT cord-104204-pdnkabwj 151 35 concentrations concentration NNS cord-104204-pdnkabwj 151 36 of of IN cord-104204-pdnkabwj 151 37 aromatic aromatic JJ cord-104204-pdnkabwj 151 38 compounds compound NNS cord-104204-pdnkabwj 151 39 in in IN cord-104204-pdnkabwj 151 40 well well JJ cord-104204-pdnkabwj 151 41 water water NN cord-104204-pdnkabwj 151 42 from from IN cord-104204-pdnkabwj 151 43 endemic endemic JJ cord-104204-pdnkabwj 151 44 villages village NNS cord-104204-pdnkabwj 151 45 and and CC cord-104204-pdnkabwj 151 46 a a DT cord-104204-pdnkabwj 151 47 nonendemic nonendemic NN cord-104204-pdnkabwj 151 48 ( ( -LRB- cord-104204-pdnkabwj 151 49 control control NN cord-104204-pdnkabwj 151 50 ) ) -RRB- cord-104204-pdnkabwj 151 51 village village NN cord-104204-pdnkabwj 151 52 . . . cord-104204-pdnkabwj 152 1 Analysis analysis NN cord-104204-pdnkabwj 152 2 of of IN cord-104204-pdnkabwj 152 3 the the DT cord-104204-pdnkabwj 152 4 Pliocene Pliocene NNP cord-104204-pdnkabwj 152 5 lignites lignite NNS cord-104204-pdnkabwj 152 6 from from IN cord-104204-pdnkabwj 152 7 endemic endemic JJ cord-104204-pdnkabwj 152 8 areas area NNS cord-104204-pdnkabwj 152 9 in in IN cord-104204-pdnkabwj 152 10 the the DT cord-104204-pdnkabwj 152 11 former former JJ cord-104204-pdnkabwj 152 12 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 152 13 using use VBG cord-104204-pdnkabwj 152 14 13C 13c CD cord-104204-pdnkabwj 152 15 nudear nudear NNP cord-104204-pdnkabwj 152 16 magnetic magnetic JJ cord-104204-pdnkabwj 152 17 resonance resonance NN cord-104204-pdnkabwj 152 18 ( ( -LRB- cord-104204-pdnkabwj 152 19 NMR NMR NNP cord-104204-pdnkabwj 152 20 ) ) -RRB- cord-104204-pdnkabwj 152 21 spectroscopy spectroscopy NN cord-104204-pdnkabwj 152 22 showed show VBD cord-104204-pdnkabwj 152 23 that that IN cord-104204-pdnkabwj 152 24 these these DT cord-104204-pdnkabwj 152 25 coals coal NNS cord-104204-pdnkabwj 152 26 are be VBP cord-104204-pdnkabwj 152 27 of of IN cord-104204-pdnkabwj 152 28 very very RB cord-104204-pdnkabwj 152 29 low low JJ cord-104204-pdnkabwj 152 30 rank rank NN cord-104204-pdnkabwj 152 31 ( ( -LRB- cord-104204-pdnkabwj 152 32 highly highly RB cord-104204-pdnkabwj 152 33 unaltered unaltered JJ cord-104204-pdnkabwj 152 34 ) ) -RRB- cord-104204-pdnkabwj 152 35 and and CC cord-104204-pdnkabwj 152 36 retain retain VB cord-104204-pdnkabwj 152 37 a a DT cord-104204-pdnkabwj 152 38 very very RB cord-104204-pdnkabwj 152 39 high high JJ cord-104204-pdnkabwj 152 40 degree degree NN cord-104204-pdnkabwj 152 41 of of IN cord-104204-pdnkabwj 152 42 organic organic JJ cord-104204-pdnkabwj 152 43 functionality functionality NN cord-104204-pdnkabwj 152 44 ( ( -LRB- cord-104204-pdnkabwj 152 45 e.g. e.g. RB cord-104204-pdnkabwj 152 46 , , , cord-104204-pdnkabwj 152 47 methoxyl methoxyl NNP cord-104204-pdnkabwj 152 48 , , , cord-104204-pdnkabwj 152 49 phenolic phenolic JJ cord-104204-pdnkabwj 152 50 , , , cord-104204-pdnkabwj 152 51 and and CC cord-104204-pdnkabwj 152 52 0-bonded 0-bonded CD cord-104204-pdnkabwj 152 53 aliphatic aliphatic JJ cord-104204-pdnkabwj 152 54 hydrocarbons hydrocarbon NNS cord-104204-pdnkabwj 152 55 ) ) -RRB- cord-104204-pdnkabwj 152 56 , , , cord-104204-pdnkabwj 152 57 as as IN cord-104204-pdnkabwj 152 58 shown show VBN cord-104204-pdnkabwj 152 59 in in IN cord-104204-pdnkabwj 152 60 Figure Figure NNP cord-104204-pdnkabwj 152 61 6 6 CD cord-104204-pdnkabwj 152 62 . . . cord-104204-pdnkabwj 153 1 The the DT cord-104204-pdnkabwj 153 2 high high JJ cord-104204-pdnkabwj 153 3 degree degree NN cord-104204-pdnkabwj 153 4 of of IN cord-104204-pdnkabwj 153 5 organic organic JJ cord-104204-pdnkabwj 153 6 oxygen oxygen NN cord-104204-pdnkabwj 153 7 functionality functionality NN cord-104204-pdnkabwj 153 8 probably probably RB cord-104204-pdnkabwj 153 9 imparts impart VBZ cord-104204-pdnkabwj 153 10 a a DT cord-104204-pdnkabwj 153 11 high high JJ cord-104204-pdnkabwj 153 12 degree degree NN cord-104204-pdnkabwj 153 13 of of IN cord-104204-pdnkabwj 153 14 aqueous aqueous JJ cord-104204-pdnkabwj 153 15 solubiity solubiity NN cord-104204-pdnkabwj 153 16 to to IN cord-104204-pdnkabwj 153 17 these these DT cord-104204-pdnkabwj 153 18 coals coal NNS cord-104204-pdnkabwj 153 19 compared compare VBN cord-104204-pdnkabwj 153 20 to to IN cord-104204-pdnkabwj 153 21 more more RBR cord-104204-pdnkabwj 153 22 altered altered JJ cord-104204-pdnkabwj 153 23 coal coal NN cord-104204-pdnkabwj 153 24 . . . cord-104204-pdnkabwj 154 1 This this DT cord-104204-pdnkabwj 154 2 high high JJ cord-104204-pdnkabwj 154 3 degree degree NN cord-104204-pdnkabwj 154 4 of of IN cord-104204-pdnkabwj 154 5 water water NN cord-104204-pdnkabwj 154 6 solubiity solubiity NN cord-104204-pdnkabwj 154 7 was be VBD cord-104204-pdnkabwj 154 8 also also RB cord-104204-pdnkabwj 154 9 observed observe VBN cord-104204-pdnkabwj 154 10 in in IN cord-104204-pdnkabwj 154 11 leaching leach VBG cord-104204-pdnkabwj 154 12 experiments experiment NNS cord-104204-pdnkabwj 154 13 carried carry VBN cord-104204-pdnkabwj 154 14 out out RP cord-104204-pdnkabwj 154 15 on on IN cord-104204-pdnkabwj 154 16 the the DT cord-104204-pdnkabwj 154 17 coal coal NN cord-104204-pdnkabwj 154 18 samples sample NNS cord-104204-pdnkabwj 154 19 . . . cord-104204-pdnkabwj 155 1 Pliocene Pliocene NNP cord-104204-pdnkabwj 155 2 lignites lignite NNS cord-104204-pdnkabwj 155 3 from from IN cord-104204-pdnkabwj 155 4 the the DT cord-104204-pdnkabwj 155 5 endemic endemic JJ cord-104204-pdnkabwj 155 6 areas area NNS cord-104204-pdnkabwj 155 7 were be VBD cord-104204-pdnkabwj 155 8 leached leach VBN cord-104204-pdnkabwj 155 9 with with IN cord-104204-pdnkabwj 155 10 distilled distil VBN cord-104204-pdnkabwj 155 11 water water NN cord-104204-pdnkabwj 155 12 in in IN cord-104204-pdnkabwj 155 13 the the DT cord-104204-pdnkabwj 155 14 laboratory laboratory NN cord-104204-pdnkabwj 155 15 to to TO cord-104204-pdnkabwj 155 16 simulate simulate VB cord-104204-pdnkabwj 155 17 groundwater groundwater NN cord-104204-pdnkabwj 155 18 leaching leaching NN cord-104204-pdnkabwj 155 19 . . . cord-104204-pdnkabwj 156 1 The the DT cord-104204-pdnkabwj 156 2 resulting result VBG cord-104204-pdnkabwj 156 3 aqueous aqueous JJ cord-104204-pdnkabwj 156 4 extract extract NN cord-104204-pdnkabwj 156 5 had have VBD cord-104204-pdnkabwj 156 6 a a DT cord-104204-pdnkabwj 156 7 distinctive distinctive JJ cord-104204-pdnkabwj 156 8 yellow yellow JJ cord-104204-pdnkabwj 156 9 tint tint NN cord-104204-pdnkabwj 156 10 , , , cord-104204-pdnkabwj 156 11 indicating indicate VBG cord-104204-pdnkabwj 156 12 the the DT cord-104204-pdnkabwj 156 13 presence presence NN cord-104204-pdnkabwj 156 14 of of IN cord-104204-pdnkabwj 156 15 dissolved dissolve VBN cord-104204-pdnkabwj 156 16 organic organic JJ cord-104204-pdnkabwj 156 17 matter matter NN cord-104204-pdnkabwj 156 18 . . . cord-104204-pdnkabwj 157 1 The the DT cord-104204-pdnkabwj 157 2 yield yield NN cord-104204-pdnkabwj 157 3 of of IN cord-104204-pdnkabwj 157 4 dissolved dissolve VBN cord-104204-pdnkabwj 157 5 organic organic JJ cord-104204-pdnkabwj 157 6 matter matter NN cord-104204-pdnkabwj 157 7 from from IN cord-104204-pdnkabwj 157 8 the the DT cord-104204-pdnkabwj 157 9 leaching leach VBG cord-104204-pdnkabwj 157 10 experiments experiment NNS cord-104204-pdnkabwj 157 11 was be VBD cord-104204-pdnkabwj 157 12 100 100 CD cord-104204-pdnkabwj 157 13 - - SYM cord-104204-pdnkabwj 157 14 500 500 CD cord-104204-pdnkabwj 157 15 mg mg NN cord-104204-pdnkabwj 157 16 from from IN cord-104204-pdnkabwj 157 17 30 30 CD cord-104204-pdnkabwj 157 18 g g NN cord-104204-pdnkabwj 157 19 of of IN cord-104204-pdnkabwj 157 20 starting start VBG cord-104204-pdnkabwj 157 21 coal coal NN cord-104204-pdnkabwj 157 22 . . . cord-104204-pdnkabwj 158 1 The the DT cord-104204-pdnkabwj 158 2 13C 13c CD cord-104204-pdnkabwj 158 3 NMR NMR NNP cord-104204-pdnkabwj 158 4 spectra spectrum NNS cord-104204-pdnkabwj 158 5 of of IN cord-104204-pdnkabwj 158 6 the the DT cord-104204-pdnkabwj 158 7 dissolved dissolve VBN cord-104204-pdnkabwj 158 8 organic organic JJ cord-104204-pdnkabwj 158 9 matter matter NN cord-104204-pdnkabwj 158 10 from from IN cord-104204-pdnkabwj 158 11 the the DT cord-104204-pdnkabwj 158 12 leaching leach VBG cord-104204-pdnkabwj 158 13 experiments experiment NNS cord-104204-pdnkabwj 158 14 are be VBP cord-104204-pdnkabwj 158 15 shown show VBN cord-104204-pdnkabwj 158 16 in in IN cord-104204-pdnkabwj 158 17 Figure Figure NNP cord-104204-pdnkabwj 158 18 7 7 CD cord-104204-pdnkabwj 158 19 . . . cord-104204-pdnkabwj 159 1 The the DT cord-104204-pdnkabwj 159 2 spectra spectrum NNS cord-104204-pdnkabwj 159 3 show show VBP cord-104204-pdnkabwj 159 4 a a DT cord-104204-pdnkabwj 159 5 large large JJ cord-104204-pdnkabwj 159 6 peak peak NN cord-104204-pdnkabwj 159 7 in in IN cord-104204-pdnkabwj 159 8 the the DT cord-104204-pdnkabwj 159 9 110 110 CD cord-104204-pdnkabwj 159 10 - - SYM cord-104204-pdnkabwj 159 11 150 150 CD cord-104204-pdnkabwj 159 12 ppm ppm NN cord-104204-pdnkabwj 159 13 region region NN cord-104204-pdnkabwj 159 14 , , , cord-104204-pdnkabwj 159 15 suggesting suggest VBG cord-104204-pdnkabwj 159 16 a a DT cord-104204-pdnkabwj 159 17 high high JJ cord-104204-pdnkabwj 159 18 degree degree NN cord-104204-pdnkabwj 159 19 of of IN cord-104204-pdnkabwj 159 20 condensed condensed JJ cord-104204-pdnkabwj 159 21 aromatic aromatic JJ cord-104204-pdnkabwj 159 22 character character NN cord-104204-pdnkabwj 159 23 in in IN cord-104204-pdnkabwj 159 24 the the DT cord-104204-pdnkabwj 159 25 dissolved dissolve VBN cord-104204-pdnkabwj 159 26 organic organic JJ cord-104204-pdnkabwj 159 27 matter matter NN cord-104204-pdnkabwj 159 28 leachate leachate NN cord-104204-pdnkabwj 159 29 . . . cord-104204-pdnkabwj 160 1 This this DT cord-104204-pdnkabwj 160 2 is be VBZ cord-104204-pdnkabwj 160 3 consistent consistent JJ cord-104204-pdnkabwj 160 4 with with IN cord-104204-pdnkabwj 160 5 the the DT cord-104204-pdnkabwj 160 6 presence presence NN cord-104204-pdnkabwj 160 7 of of IN cord-104204-pdnkabwj 160 8 polycyclic polycyclic JJ cord-104204-pdnkabwj 160 9 aromatic aromatic JJ cord-104204-pdnkabwj 160 10 structures structure NNS cord-104204-pdnkabwj 160 11 . . . cord-104204-pdnkabwj 161 1 The the DT cord-104204-pdnkabwj 161 2 leachates leachate NNS cord-104204-pdnkabwj 161 3 also also RB cord-104204-pdnkabwj 161 4 contain contain VBP cord-104204-pdnkabwj 161 5 aliphatic aliphatic JJ cord-104204-pdnkabwj 161 6 hydrocarbon hydrocarbon NN cord-104204-pdnkabwj 161 7 structures structure NNS cord-104204-pdnkabwj 161 8 ( ( -LRB- cord-104204-pdnkabwj 161 9 peak peak NN cord-104204-pdnkabwj 161 10 at at IN cord-104204-pdnkabwj 161 11 0 0 CD cord-104204-pdnkabwj 161 12 - - SYM cord-104204-pdnkabwj 161 13 50 50 CD cord-104204-pdnkabwj 161 14 ppm ppm NN cord-104204-pdnkabwj 161 15 in in IN cord-104204-pdnkabwj 161 16 the the DT cord-104204-pdnkabwj 161 17 spectra spectrum NNS cord-104204-pdnkabwj 161 18 ) ) -RRB- cord-104204-pdnkabwj 161 19 and and CC cord-104204-pdnkabwj 161 20 a a DT cord-104204-pdnkabwj 161 21 high high JJ cord-104204-pdnkabwj 161 22 The the DT cord-104204-pdnkabwj 161 23 l l NN cord-104204-pdnkabwj 161 24 degree degree NN cord-104204-pdnkabwj 161 25 of of IN cord-104204-pdnkabwj 161 26 carboxyl carboxyl NN cord-104204-pdnkabwj 161 27 ( ( -LRB- cord-104204-pdnkabwj 161 28 organic organic JJ cord-104204-pdnkabwj 161 29 acid acid NN cord-104204-pdnkabwj 161 30 ) ) -RRB- cord-104204-pdnkabwj 161 31 functionali functionali NNP cord-104204-pdnkabwj 161 32 - - HYPH cord-104204-pdnkabwj 161 33 BEN BEN NNP cord-104204-pdnkabwj 161 34 etic etic NNP cord-104204-pdnkabwj 161 35 ty ty NNP cord-104204-pdnkabwj 161 36 ( ( -LRB- cord-104204-pdnkabwj 161 37 peak peak NN cord-104204-pdnkabwj 161 38 at at IN cord-104204-pdnkabwj 161 39 175 175 CD cord-104204-pdnkabwj 161 40 ppm ppm NN cord-104204-pdnkabwj 161 41 ) ) -RRB- cord-104204-pdnkabwj 161 42 . . . cord-104204-pdnkabwj 162 1 tion tion NN cord-104204-pdnkabwj 162 2 of of IN cord-104204-pdnkabwj 162 3 p p NNP cord-104204-pdnkabwj 162 4 Well Well NNP cord-104204-pdnkabwj 162 5 water water NN cord-104204-pdnkabwj 162 6 samples sample NNS cord-104204-pdnkabwj 162 7 from from IN cord-104204-pdnkabwj 162 8 two two CD cord-104204-pdnkabwj 162 9 endemic endemic JJ cord-104204-pdnkabwj 162 10 water water NN cord-104204-pdnkabwj 162 11 fr fr NN cord-104204-pdnkabwj 162 12 villages village NNS cord-104204-pdnkabwj 162 13 and and CC cord-104204-pdnkabwj 162 14 one one CD cord-104204-pdnkabwj 162 15 nonendemic nonendemic NN cord-104204-pdnkabwj 162 16 ( ( -LRB- cord-104204-pdnkabwj 162 17 control control NN cord-104204-pdnkabwj 162 18 ) ) -RRB- cord-104204-pdnkabwj 162 19 village village NN cord-104204-pdnkabwj 162 20 endemic endemic JJ cord-104204-pdnkabwj 162 21 in in IN cord-104204-pdnkabwj 162 22 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 162 23 were be VBD cord-104204-pdnkabwj 162 24 analyzed analyze VBN cord-104204-pdnkabwj 162 25 for for IN cord-104204-pdnkabwj 162 26 the the DT cord-104204-pdnkabwj 162 27 presence presence NN cord-104204-pdnkabwj 162 28 performe performe VB cord-104204-pdnkabwj 162 29 of of IN cord-104204-pdnkabwj 162 30 dissolved dissolved JJ cord-104204-pdnkabwj 162 31 aromatic aromatic JJ cord-104204-pdnkabwj 162 32 organic organic JJ cord-104204-pdnkabwj 162 33 matter matter NN cord-104204-pdnkabwj 162 34 using use VBG cord-104204-pdnkabwj 162 35 et et NNP cord-104204-pdnkabwj 162 36 al al NNP cord-104204-pdnkabwj 162 37 . . . cord-104204-pdnkabwj 163 1 ( ( -LRB- cord-104204-pdnkabwj 163 2 42 42 CD cord-104204-pdnkabwj 163 3 gas gas NN cord-104204-pdnkabwj 163 4 chromatography chromatography NN cord-104204-pdnkabwj 163 5 / / SYM cord-104204-pdnkabwj 163 6 mass mass NN cord-104204-pdnkabwj 163 7 spectrometry spectrometry NN cord-104204-pdnkabwj 163 8 to to IN cord-104204-pdnkabwj 163 9 rats rat NNS cord-104204-pdnkabwj 163 10 an an DT cord-104204-pdnkabwj 163 11 ( ( -LRB- cord-104204-pdnkabwj 163 12 GC GC NNP cord-104204-pdnkabwj 163 13 / / SYM cord-104204-pdnkabwj 163 14 MS MS NNP cord-104204-pdnkabwj 163 15 ) ) -RRB- cord-104204-pdnkabwj 163 16 . . . cord-104204-pdnkabwj 164 1 A a DT cord-104204-pdnkabwj 164 2 total total NN cord-104204-pdnkabwj 164 3 of of IN cord-104204-pdnkabwj 164 4 14 14 CD cord-104204-pdnkabwj 164 5 compounds compound NNS cord-104204-pdnkabwj 164 6 were be VBD cord-104204-pdnkabwj 164 7 observed observe VBN cord-104204-pdnkabwj 164 8 identified identify VBN cord-104204-pdnkabwj 164 9 in in IN cord-104204-pdnkabwj 164 10 the the DT cord-104204-pdnkabwj 164 11 samples sample NNS cord-104204-pdnkabwj 164 12 ( ( -LRB- cord-104204-pdnkabwj 164 13 Table Table NNP cord-104204-pdnkabwj 164 14 1 1 CD cord-104204-pdnkabwj 164 15 ) ) -RRB- cord-104204-pdnkabwj 164 16 , , , cord-104204-pdnkabwj 164 17 with with IN cord-104204-pdnkabwj 164 18 conin conin NNP cord-104204-pdnkabwj 164 19 the the DT cord-104204-pdnkabwj 164 20 cc cc CD cord-104204-pdnkabwj 164 21 centrations centration NNS cord-104204-pdnkabwj 164 22 in in IN cord-104204-pdnkabwj 164 23 the the DT cord-104204-pdnkabwj 164 24 low low JJ cord-104204-pdnkabwj 164 25 microgram microgram NN cord-104204-pdnkabwj 164 26 per per IN cord-104204-pdnkabwj 164 27 liter liter NN cord-104204-pdnkabwj 164 28 tions tion NNS cord-104204-pdnkabwj 164 29 of of IN cord-104204-pdnkabwj 164 30 range range NN cord-104204-pdnkabwj 164 31 . . . cord-104204-pdnkabwj 165 1 Compounds compound NNS cord-104204-pdnkabwj 165 2 4 4 CD cord-104204-pdnkabwj 165 3 , , , cord-104204-pdnkabwj 165 4 7 7 CD cord-104204-pdnkabwj 165 5 , , , cord-104204-pdnkabwj 165 6 10 10 CD cord-104204-pdnkabwj 165 7 , , , cord-104204-pdnkabwj 165 8 13 13 CD cord-104204-pdnkabwj 165 9 , , , cord-104204-pdnkabwj 165 10 and and CC cord-104204-pdnkabwj 165 11 14 14 CD cord-104204-pdnkabwj 165 12 Table table NN cord-104204-pdnkabwj 165 13 _SP cord-104204-pdnkabwj 165 14 1 1 CD cord-104204-pdnkabwj 165 15 were be VBD cord-104204-pdnkabwj 165 16 higher high JJR cord-104204-pdnkabwj 165 17 in in IN cord-104204-pdnkabwj 165 18 well well JJ cord-104204-pdnkabwj 165 19 water water NN cord-104204-pdnkabwj 165 20 from from IN cord-104204-pdnkabwj 165 21 the the DT cord-104204-pdnkabwj 165 22 endemic endemic JJ cord-104204-pdnkabwj 165 23 villages village NNS cord-104204-pdnkabwj 165 24 . . . cord-104204-pdnkabwj 166 1 Comparing compare VBG cord-104204-pdnkabwj 166 2 the the DT cord-104204-pdnkabwj 166 3 concentrations concentration NNS cord-104204-pdnkabwj 166 4 of of IN cord-104204-pdnkabwj 166 5 PAHs pah NNS cord-104204-pdnkabwj 166 6 in in IN cord-104204-pdnkabwj 166 7 well well JJ cord-104204-pdnkabwj 166 8 water water NN cord-104204-pdnkabwj 166 9 from from IN cord-104204-pdnkabwj 166 10 the the DT cord-104204-pdnkabwj 166 11 hyperendemic hyperendemic NNP cord-104204-pdnkabwj 166 12 Petka Petka NNP cord-104204-pdnkabwj 166 13 village village NN cord-104204-pdnkabwj 166 14 to to IN cord-104204-pdnkabwj 166 15 the the DT cord-104204-pdnkabwj 166 16 control control NN cord-104204-pdnkabwj 166 17 village village NN cord-104204-pdnkabwj 166 18 , , , cord-104204-pdnkabwj 166 19 the the DT cord-104204-pdnkabwj 166 20 Petka Petka NNP cord-104204-pdnkabwj 166 21 village village NN cord-104204-pdnkabwj 166 22 had have VBD cord-104204-pdnkabwj 166 23 10 10 CD cord-104204-pdnkabwj 166 24 times time NNS cord-104204-pdnkabwj 166 25 higher high JJR cord-104204-pdnkabwj 166 26 fluoranthene fluoranthene NN cord-104204-pdnkabwj 166 27 , , , cord-104204-pdnkabwj 166 28 6 6 CD cord-104204-pdnkabwj 166 29 times time NNS cord-104204-pdnkabwj 166 30 higher high JJR cord-104204-pdnkabwj 166 31 phenanthrene phenanthrene NN cord-104204-pdnkabwj 166 32 and and CC cord-104204-pdnkabwj 166 33 pyrene pyrene NN cord-104204-pdnkabwj 166 34 , , , cord-104204-pdnkabwj 166 35 5 5 CD cord-104204-pdnkabwj 166 36 times time NNS cord-104204-pdnkabwj 166 37 higher high JJR cord-104204-pdnkabwj 166 38 anthracene anthracene NN cord-104204-pdnkabwj 166 39 , , , cord-104204-pdnkabwj 166 40 and and CC cord-104204-pdnkabwj 166 41 2 2 CD cord-104204-pdnkabwj 166 42 - - SYM cord-104204-pdnkabwj 166 43 3 3 CD cord-104204-pdnkabwj 166 44 times time NNS cord-104204-pdnkabwj 166 45 higher high JJR cord-104204-pdnkabwj 166 46 concentrations concentration NNS cord-104204-pdnkabwj 166 47 of of IN cord-104204-pdnkabwj 166 48 all all DT cord-104204-pdnkabwj 166 49 other other JJ cord-104204-pdnkabwj 166 50 PAHs pah NNS cord-104204-pdnkabwj 166 51 . . . cord-104204-pdnkabwj 167 1 The the DT cord-104204-pdnkabwj 167 2 higher high JJR cord-104204-pdnkabwj 167 3 concentrations concentration NNS cord-104204-pdnkabwj 167 4 of of IN cord-104204-pdnkabwj 167 5 PAHs pah NNS cord-104204-pdnkabwj 167 6 in in IN cord-104204-pdnkabwj 167 7 the the DT cord-104204-pdnkabwj 167 8 endemic endemic JJ cord-104204-pdnkabwj 167 9 Petka Petka NNP cord-104204-pdnkabwj 167 10 village village NN cord-104204-pdnkabwj 167 11 may may MD cord-104204-pdnkabwj 167 12 be be VB cord-104204-pdnkabwj 167 13 linked link VBN cord-104204-pdnkabwj 167 14 to to IN cord-104204-pdnkabwj 167 15 the the DT cord-104204-pdnkabwj 167 16 high high JJ cord-104204-pdnkabwj 167 17 incidence incidence NN cord-104204-pdnkabwj 167 18 of of IN cord-104204-pdnkabwj 167 19 urothelial urothelial JJ cord-104204-pdnkabwj 167 20 cancer cancer NN cord-104204-pdnkabwj 167 21 associated associate VBN cord-104204-pdnkabwj 167 22 with with IN cord-104204-pdnkabwj 167 23 BEN BEN NNP cord-104204-pdnkabwj 167 24 . . . cord-104204-pdnkabwj 168 1 Potential potential JJ cord-104204-pdnkabwj 168 2 nephrotoxic nephrotoxic NN cord-104204-pdnkabwj 168 3 agents agent NNS cord-104204-pdnkabwj 168 4 such such JJ cord-104204-pdnkabwj 168 5 as as IN cord-104204-pdnkabwj 168 6 aminophenols aminophenol NNS cord-104204-pdnkabwj 168 7 or or CC cord-104204-pdnkabwj 168 8 aromatic aromatic JJ cord-104204-pdnkabwj 168 9 amines amine NNS cord-104204-pdnkabwj 168 10 were be VBD cord-104204-pdnkabwj 168 11 not not RB cord-104204-pdnkabwj 168 12 analyzed analyze VBN cord-104204-pdnkabwj 168 13 in in IN cord-104204-pdnkabwj 168 14 this this DT cord-104204-pdnkabwj 168 15 study study NN cord-104204-pdnkabwj 168 16 , , , cord-104204-pdnkabwj 168 17 although although IN cord-104204-pdnkabwj 168 18 previous previous JJ cord-104204-pdnkabwj 168 19 work work NN cord-104204-pdnkabwj 168 20 has have VBZ cord-104204-pdnkabwj 168 21 indicated indicate VBN cord-104204-pdnkabwj 168 22 the the DT cord-104204-pdnkabwj 168 23 presence presence NN cord-104204-pdnkabwj 168 24 of of IN cord-104204-pdnkabwj 168 25 aromatic aromatic JJ cord-104204-pdnkabwj 168 26 amines amine NNS cord-104204-pdnkabwj 168 27 in in IN cord-104204-pdnkabwj 168 28 well well JJ cord-104204-pdnkabwj 168 29 water water NN cord-104204-pdnkabwj 168 30 from from IN cord-104204-pdnkabwj 168 31 endemic endemic JJ cord-104204-pdnkabwj 168 32 villages village NNS cord-104204-pdnkabwj 168 33 ( ( -LRB- cord-104204-pdnkabwj 168 34 29 29 CD cord-104204-pdnkabwj 168 35 ) ) -RRB- cord-104204-pdnkabwj 168 36 . . . cord-104204-pdnkabwj 169 1 More more RBR cord-104204-pdnkabwj 169 2 additional additional JJ cord-104204-pdnkabwj 169 3 work work NN cord-104204-pdnkabwj 169 4 induding indude VBG cord-104204-pdnkabwj 169 5 analyses analysis NNS cord-104204-pdnkabwj 169 6 of of IN cord-104204-pdnkabwj 169 7 more more JJR cord-104204-pdnkabwj 169 8 well well JJ cord-104204-pdnkabwj 169 9 water water NN cord-104204-pdnkabwj 169 10 samples sample NNS cord-104204-pdnkabwj 169 11 and and CC cord-104204-pdnkabwj 169 12 screening screen VBG cord-104204-pdnkabwj 169 13 for for IN cord-104204-pdnkabwj 169 14 more more RBR cord-104204-pdnkabwj 169 15 potentially potentially RB cord-104204-pdnkabwj 169 16 carcinogenic carcinogenic JJ cord-104204-pdnkabwj 169 17 and and CC cord-104204-pdnkabwj 169 18 nephrotoxic nephrotoxic JJ cord-104204-pdnkabwj 169 19 organic organic JJ cord-104204-pdnkabwj 169 20 substances substance NNS cord-104204-pdnkabwj 169 21 is be VBZ cord-104204-pdnkabwj 169 22 needed need VBN cord-104204-pdnkabwj 169 23 to to TO cord-104204-pdnkabwj 169 24 validate validate VB cord-104204-pdnkabwj 169 25 the the DT cord-104204-pdnkabwj 169 26 Pliocene Pliocene NNP cord-104204-pdnkabwj 169 27 lignite lignite NN cord-104204-pdnkabwj 169 28 role role NN cord-104204-pdnkabwj 169 29 in in IN cord-104204-pdnkabwj 169 30 BEN BEN NNP cord-104204-pdnkabwj 169 31 etiology etiology NN cord-104204-pdnkabwj 169 32 . . . cord-104204-pdnkabwj 170 1 link link NN cord-104204-pdnkabwj 170 2 between between IN cord-104204-pdnkabwj 170 3 the the DT cord-104204-pdnkabwj 170 4 low low JJ cord-104204-pdnkabwj 170 5 - - HYPH cord-104204-pdnkabwj 170 6 rank rank NN cord-104204-pdnkabwj 170 7 coals coal NNS cord-104204-pdnkabwj 170 8 and and CC cord-104204-pdnkabwj 170 9 ology ology NN cord-104204-pdnkabwj 170 10 is be VBZ cord-104204-pdnkabwj 170 11 also also RB cord-104204-pdnkabwj 170 12 reinforced reinforce VBN cord-104204-pdnkabwj 170 13 by by IN cord-104204-pdnkabwj 170 14 the the DT cord-104204-pdnkabwj 170 15 detechenolic detechenolic NNP cord-104204-pdnkabwj 170 16 compounds compound NNS cord-104204-pdnkabwj 170 17 in in IN cord-104204-pdnkabwj 170 18 the the DT cord-104204-pdnkabwj 170 19 drinking drinking NN cord-104204-pdnkabwj 170 20 rom rom NN cord-104204-pdnkabwj 170 21 wells well NNS cord-104204-pdnkabwj 170 22 in in IN cord-104204-pdnkabwj 170 23 several several JJ cord-104204-pdnkabwj 170 24 Romanian romanian JJ cord-104204-pdnkabwj 170 25 villages village NNS cord-104204-pdnkabwj 170 26 and and CC cord-104204-pdnkabwj 170 27 by by IN cord-104204-pdnkabwj 170 28 animal animal NN cord-104204-pdnkabwj 170 29 experiments experiment NNS cord-104204-pdnkabwj 170 30 ed ed NN cord-104204-pdnkabwj 170 31 in in IN cord-104204-pdnkabwj 170 32 the the DT cord-104204-pdnkabwj 170 33 1970s 1970 NNS cord-104204-pdnkabwj 170 34 in in IN cord-104204-pdnkabwj 170 35 Romania Romania NNP cord-104204-pdnkabwj 170 36 . . . cord-104204-pdnkabwj 171 1 Bordas Bordas NNP cord-104204-pdnkabwj 171 2 2l 2l NN cord-104204-pdnkabwj 171 3 fed feed VBD cord-104204-pdnkabwj 171 4 endemic endemic JJ cord-104204-pdnkabwj 171 5 region region NN cord-104204-pdnkabwj 171 6 water water NN cord-104204-pdnkabwj 171 7 extracts extract VBZ cord-104204-pdnkabwj 171 8 nd nd NNP cord-104204-pdnkabwj 171 9 mice mouse NNS cord-104204-pdnkabwj 171 10 for for IN cord-104204-pdnkabwj 171 11 6 6 CD cord-104204-pdnkabwj 171 12 months month NNS cord-104204-pdnkabwj 171 13 to to IN cord-104204-pdnkabwj 171 14 1 1 CD cord-104204-pdnkabwj 171 15 year year NN cord-104204-pdnkabwj 171 16 ; ; : cord-104204-pdnkabwj 171 17 they -PRON- PRP cord-104204-pdnkabwj 171 18 renal renal JJ cord-104204-pdnkabwj 171 19 lesions lesion NNS cord-104204-pdnkabwj 171 20 that that WDT cord-104204-pdnkabwj 171 21 were be VBD cord-104204-pdnkabwj 171 22 not not RB cord-104204-pdnkabwj 171 23 found find VBN cord-104204-pdnkabwj 171 24 rntrol rntrol NNP cord-104204-pdnkabwj 171 25 group group NN cord-104204-pdnkabwj 171 26 . . . cord-104204-pdnkabwj 172 1 Preliminary preliminary JJ cord-104204-pdnkabwj 172 2 investigathe investigathe NNP cord-104204-pdnkabwj 172 3 geological geological JJ cord-104204-pdnkabwj 172 4 environment environment NN cord-104204-pdnkabwj 172 5 of of IN cord-104204-pdnkabwj 172 6 the the DT cord-104204-pdnkabwj 172 7 an an DT cord-104204-pdnkabwj 172 8 BEN BEN NNP cord-104204-pdnkabwj 172 9 locations location NNS cord-104204-pdnkabwj 172 10 also also RB cord-104204-pdnkabwj 172 11 revealed reveal VBD cord-104204-pdnkabwj 172 12 the the DT cord-104204-pdnkabwj 172 13 ity ity NN cord-104204-pdnkabwj 172 14 of of IN cord-104204-pdnkabwj 172 15 endemic endemic JJ cord-104204-pdnkabwj 172 16 villages village NNS cord-104204-pdnkabwj 172 17 to to TO cord-104204-pdnkabwj 172 18 coal coal NN cord-104204-pdnkabwj 172 19 .Hence .Hence NFP cord-104204-pdnkabwj 172 20 , , , cord-104204-pdnkabwj 172 21 endemic endemic JJ cord-104204-pdnkabwj 172 22 villages village NNS cord-104204-pdnkabwj 172 23 near near IN cord-104204-pdnkabwj 172 24 the the DT cord-104204-pdnkabwj 172 25 Jiu Jiu NNP cord-104204-pdnkabwj 172 26 , , , cord-104204-pdnkabwj 172 27 and and CC cord-104204-pdnkabwj 172 28 Cerna Cerna NNP cord-104204-pdnkabwj 172 29 Rivers Rivers NNPS cord-104204-pdnkabwj 172 30 adjoin adjoin VBP cord-104204-pdnkabwj 172 31 the the DT cord-104204-pdnkabwj 172 32 Pliocene Pliocene NNP cord-104204-pdnkabwj 172 33 Oltenian Oltenian NNP cord-104204-pdnkabwj 172 34 lignite lignite NN cord-104204-pdnkabwj 172 35 deposits deposit NNS cord-104204-pdnkabwj 172 36 , , , cord-104204-pdnkabwj 172 37 e e NNP cord-104204-pdnkabwj 172 38 villages village NNS cord-104204-pdnkabwj 172 39 south south RB cord-104204-pdnkabwj 172 40 of of IN cord-104204-pdnkabwj 172 41 the the DT cord-104204-pdnkabwj 172 42 Carasul Carasul NNP cord-104204-pdnkabwj 172 43 River River NNP cord-104204-pdnkabwj 172 44 roximity roximity NN cord-104204-pdnkabwj 172 45 with with IN cord-104204-pdnkabwj 172 46 smaller small JJR cord-104204-pdnkabwj 172 47 Pliocene pliocene JJ cord-104204-pdnkabwj 172 48 ligosits ligosit NNS cord-104204-pdnkabwj 172 49 from from IN cord-104204-pdnkabwj 172 50 the the DT cord-104204-pdnkabwj 172 51 Carasova Carasova NNP cord-104204-pdnkabwj 172 52 and and CC cord-104204-pdnkabwj 172 53 Oravita Oravita NNP cord-104204-pdnkabwj 172 54 43 43 CD cord-104204-pdnkabwj 172 55 ) ) -RRB- cord-104204-pdnkabwj 172 56 . . . cord-104204-pdnkabwj 173 1 Field field NN cord-104204-pdnkabwj 173 2 investigations investigation NNS cord-104204-pdnkabwj 173 3 in in IN cord-104204-pdnkabwj 173 4 several several JJ cord-104204-pdnkabwj 173 5 villages village NNS cord-104204-pdnkabwj 173 6 in in IN cord-104204-pdnkabwj 173 7 Romania Romania NNP cord-104204-pdnkabwj 173 8 also also RB cord-104204-pdnkabwj 173 9 showed show VBD cord-104204-pdnkabwj 173 10 presence presence NN cord-104204-pdnkabwj 173 11 of of IN cord-104204-pdnkabwj 173 12 only only RB cord-104204-pdnkabwj 173 13 one one CD cord-104204-pdnkabwj 173 14 or or CC cord-104204-pdnkabwj 173 15 a a DT cord-104204-pdnkabwj 173 16 few few JJ cord-104204-pdnkabwj 173 17 well well JJ cord-104204-pdnkabwj 173 18 water water NN cord-104204-pdnkabwj 173 19 supplies supply NNS cord-104204-pdnkabwj 173 20 used use VBN cord-104204-pdnkabwj 173 21 by by IN cord-104204-pdnkabwj 173 22 all all DT cord-104204-pdnkabwj 173 23 or or CC cord-104204-pdnkabwj 173 24 almost almost RB cord-104204-pdnkabwj 173 25 all all DT cord-104204-pdnkabwj 173 26 of of IN cord-104204-pdnkabwj 173 27 the the DT cord-104204-pdnkabwj 173 28 village village NN cord-104204-pdnkabwj 173 29 is be VBZ cord-104204-pdnkabwj 173 30 apparently apparently RB cord-104204-pdnkabwj 173 31 associated associate VBN cord-104204-pdnkabwj 173 32 with with IN cord-104204-pdnkabwj 173 33 a a DT cord-104204-pdnkabwj 173 34 hyperendemic hyperendemic JJ cord-104204-pdnkabwj 173 35 character character NN cord-104204-pdnkabwj 173 36 of of IN cord-104204-pdnkabwj 173 37 BEN BEN NNP cord-104204-pdnkabwj 173 38 . . . cord-104204-pdnkabwj 174 1 That that RB cord-104204-pdnkabwj 174 2 is is RB cord-104204-pdnkabwj 174 3 , , , cord-104204-pdnkabwj 174 4 a a DT cord-104204-pdnkabwj 174 5 higher high JJR cord-104204-pdnkabwj 174 6 incidence incidence NN cord-104204-pdnkabwj 174 7 of of IN cord-104204-pdnkabwj 174 8 the the DT cord-104204-pdnkabwj 174 9 disease disease NN cord-104204-pdnkabwj 174 10 and and CC cord-104204-pdnkabwj 174 11 more more JJR cord-104204-pdnkabwj 174 12 families family NNS cord-104204-pdnkabwj 174 13 ( ( -LRB- cord-104204-pdnkabwj 174 14 living live VBG cord-104204-pdnkabwj 174 15 in in IN cord-104204-pdnkabwj 174 16 different different JJ cord-104204-pdnkabwj 174 17 households household NNS cord-104204-pdnkabwj 174 18 ) ) -RRB- cord-104204-pdnkabwj 174 19 were be VBD cord-104204-pdnkabwj 174 20 affected affect VBN cord-104204-pdnkabwj 174 21 compared compare VBN cord-104204-pdnkabwj 174 22 to to IN cord-104204-pdnkabwj 174 23 the the DT cord-104204-pdnkabwj 174 24 normoendemic normoendemic JJ cord-104204-pdnkabwj 174 25 or or CC cord-104204-pdnkabwj 174 26 hypoendemic hypoendemic JJ cord-104204-pdnkabwj 174 27 regions region NNS cord-104204-pdnkabwj 174 28 . . . cord-104204-pdnkabwj 175 1 Other other JJ cord-104204-pdnkabwj 175 2 studies study NNS cord-104204-pdnkabwj 175 3 conducted conduct VBN cord-104204-pdnkabwj 175 4 in in IN cord-104204-pdnkabwj 175 5 the the DT cord-104204-pdnkabwj 175 6 1960s 1960 NNS cord-104204-pdnkabwj 175 7 in in IN cord-104204-pdnkabwj 175 8 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 175 9 also also RB cord-104204-pdnkabwj 175 10 support support VBP cord-104204-pdnkabwj 175 11 a a DT cord-104204-pdnkabwj 175 12 hydrogeological hydrogeological JJ cord-104204-pdnkabwj 175 13 origin origin NN cord-104204-pdnkabwj 175 14 of of IN cord-104204-pdnkabwj 175 15 the the DT cord-104204-pdnkabwj 175 16 disease disease NN cord-104204-pdnkabwj 175 17 . . . cord-104204-pdnkabwj 176 1 Field field NN cord-104204-pdnkabwj 176 2 studies study NNS cord-104204-pdnkabwj 176 3 performed perform VBN cord-104204-pdnkabwj 176 4 in in IN cord-104204-pdnkabwj 176 5 a a DT cord-104204-pdnkabwj 176 6 village village NN cord-104204-pdnkabwj 176 7 ( ( -LRB- cord-104204-pdnkabwj 176 8 Glogovac Glogovac NNP cord-104204-pdnkabwj 176 9 ) ) -RRB- cord-104204-pdnkabwj 176 10 located locate VBN cord-104204-pdnkabwj 176 11 at at IN cord-104204-pdnkabwj 176 12 the the DT cord-104204-pdnkabwj 176 13 border border NN cord-104204-pdnkabwj 176 14 between between IN cord-104204-pdnkabwj 176 15 the the DT cord-104204-pdnkabwj 176 16 endemic endemic JJ cord-104204-pdnkabwj 176 17 and and CC cord-104204-pdnkabwj 176 18 the the DT cord-104204-pdnkabwj 176 19 nonend.emic nonend.emic JJ cord-104204-pdnkabwj 176 20 regions region NNS cord-104204-pdnkabwj 176 21 in in IN cord-104204-pdnkabwj 176 22 Bosnia Bosnia NNP cord-104204-pdnkabwj 176 23 revealed reveal VBD cord-104204-pdnkabwj 176 24 a a DT cord-104204-pdnkabwj 176 25 striking strike VBG cord-104204-pdnkabwj 176 26 association association NN cord-104204-pdnkabwj 176 27 between between IN cord-104204-pdnkabwj 176 28 BEN BEN NNP cord-104204-pdnkabwj 176 29 incidence incidence NN cord-104204-pdnkabwj 176 30 , , , cord-104204-pdnkabwj 176 31 mortality mortality NN cord-104204-pdnkabwj 176 32 due due IN cord-104204-pdnkabwj 176 33 to to IN cord-104204-pdnkabwj 176 34 BEN BEN NNP cord-104204-pdnkabwj 176 35 , , , cord-104204-pdnkabwj 176 36 and and CC cord-104204-pdnkabwj 176 37 altitude altitude NN cord-104204-pdnkabwj 176 38 ( ( -LRB- cord-104204-pdnkabwj 176 39 44 44 CD cord-104204-pdnkabwj 176 40 ) ) -RRB- cord-104204-pdnkabwj 176 41 . . . cord-104204-pdnkabwj 177 1 Glogovac Glogovac NNP cord-104204-pdnkabwj 177 2 is be VBZ cord-104204-pdnkabwj 177 3 made make VBN cord-104204-pdnkabwj 177 4 up up RP cord-104204-pdnkabwj 177 5 of of IN cord-104204-pdnkabwj 177 6 two two CD cord-104204-pdnkabwj 177 7 parts part NNS cord-104204-pdnkabwj 177 8 : : : cord-104204-pdnkabwj 177 9 Lower lower VB cord-104204-pdnkabwj 177 10 Glogovac Glogovac NNP cord-104204-pdnkabwj 177 11 ( ( -LRB- cord-104204-pdnkabwj 177 12 an an DT cord-104204-pdnkabwj 177 13 average average JJ cord-104204-pdnkabwj 177 14 100 100 CD cord-104204-pdnkabwj 177 15 m m NN cord-104204-pdnkabwj 177 16 above above IN cord-104204-pdnkabwj 177 17 sea sea NN cord-104204-pdnkabwj 177 18 level level NN cord-104204-pdnkabwj 177 19 ) ) -RRB- cord-104204-pdnkabwj 177 20 and and CC cord-104204-pdnkabwj 177 21 Upper Upper NNP cord-104204-pdnkabwj 177 22 Glogovac Glogovac NNP cord-104204-pdnkabwj 177 23 ( ( -LRB- cord-104204-pdnkabwj 177 24 an an DT cord-104204-pdnkabwj 177 25 average average JJ cord-104204-pdnkabwj 177 26 115 115 CD cord-104204-pdnkabwj 177 27 m m NN cord-104204-pdnkabwj 177 28 above above IN cord-104204-pdnkabwj 177 29 sea sea NN cord-104204-pdnkabwj 177 30 level level NN cord-104204-pdnkabwj 177 31 ) ) -RRB- cord-104204-pdnkabwj 177 32 . . . cord-104204-pdnkabwj 178 1 While while IN cord-104204-pdnkabwj 178 2 there there EX cord-104204-pdnkabwj 178 3 is be VBZ cord-104204-pdnkabwj 178 4 no no DT cord-104204-pdnkabwj 178 5 difference difference NN cord-104204-pdnkabwj 178 6 between between IN cord-104204-pdnkabwj 178 7 the the DT cord-104204-pdnkabwj 178 8 two two CD cord-104204-pdnkabwj 178 9 parts part NNS cord-104204-pdnkabwj 178 10 in in IN cord-104204-pdnkabwj 178 11 population population NN cord-104204-pdnkabwj 178 12 origin origin NN cord-104204-pdnkabwj 178 13 , , , cord-104204-pdnkabwj 178 14 housing housing NN cord-104204-pdnkabwj 178 15 conditions condition NNS cord-104204-pdnkabwj 178 16 , , , cord-104204-pdnkabwj 178 17 diet diet NN cord-104204-pdnkabwj 178 18 , , , cord-104204-pdnkabwj 178 19 customs custom NNS cord-104204-pdnkabwj 178 20 , , , cord-104204-pdnkabwj 178 21 occupations occupation NNS cord-104204-pdnkabwj 178 22 , , , cord-104204-pdnkabwj 178 23 or or CC cord-104204-pdnkabwj 178 24 economical economical JJ cord-104204-pdnkabwj 178 25 , , , cord-104204-pdnkabwj 178 26 social social JJ cord-104204-pdnkabwj 178 27 , , , cord-104204-pdnkabwj 178 28 or or CC cord-104204-pdnkabwj 178 29 ecological ecological JJ cord-104204-pdnkabwj 178 30 conditions condition NNS cord-104204-pdnkabwj 178 31 , , , cord-104204-pdnkabwj 178 32 BEN BEN NNP cord-104204-pdnkabwj 178 33 occurs occur VBZ cord-104204-pdnkabwj 178 34 more more RBR cord-104204-pdnkabwj 178 35 frequently frequently RB cord-104204-pdnkabwj 178 36 , , , cord-104204-pdnkabwj 178 37 and and CC cord-104204-pdnkabwj 178 38 more more JJR cord-104204-pdnkabwj 178 39 households household NNS cord-104204-pdnkabwj 178 40 are be VBP cord-104204-pdnkabwj 178 41 affected affect VBN cord-104204-pdnkabwj 178 42 in in IN cord-104204-pdnkabwj 178 43 the the DT cord-104204-pdnkabwj 178 44 Lower low JJR cord-104204-pdnkabwj 178 45 Glogovac Glogovac NNP cord-104204-pdnkabwj 178 46 than than IN cord-104204-pdnkabwj 178 47 in in IN cord-104204-pdnkabwj 178 48 the the DT cord-104204-pdnkabwj 178 49 Higher Higher NNP cord-104204-pdnkabwj 178 50 Glogovac Glogovac NNP cord-104204-pdnkabwj 178 51 . . . cord-104204-pdnkabwj 179 1 The the DT cord-104204-pdnkabwj 179 2 only only JJ cord-104204-pdnkabwj 179 3 notable notable JJ cord-104204-pdnkabwj 179 4 differences difference NNS cord-104204-pdnkabwj 179 5 between between IN cord-104204-pdnkabwj 179 6 the the DT cord-104204-pdnkabwj 179 7 two two CD cord-104204-pdnkabwj 179 8 parts part NNS cord-104204-pdnkabwj 179 9 are be VBP cord-104204-pdnkabwj 179 10 altitude altitude NN cord-104204-pdnkabwj 179 11 ( ( -LRB- cord-104204-pdnkabwj 179 12 10 10 CD cord-104204-pdnkabwj 179 13 - - SYM cord-104204-pdnkabwj 179 14 25 25 CD cord-104204-pdnkabwj 179 15 m m CD cord-104204-pdnkabwj 179 16 ) ) -RRB- cord-104204-pdnkabwj 179 17 and and CC cord-104204-pdnkabwj 179 18 the the DT cord-104204-pdnkabwj 179 19 depths depth NNS cord-104204-pdnkabwj 179 20 of of IN cord-104204-pdnkabwj 179 21 the the DT cord-104204-pdnkabwj 179 22 wells well NNS cord-104204-pdnkabwj 179 23 used use VBN cord-104204-pdnkabwj 179 24 as as IN cord-104204-pdnkabwj 179 25 a a DT cord-104204-pdnkabwj 179 26 water water NN cord-104204-pdnkabwj 179 27 supply supply NN cord-104204-pdnkabwj 179 28 . . . cord-104204-pdnkabwj 180 1 In in IN cord-104204-pdnkabwj 180 2 Lower Lower NNP cord-104204-pdnkabwj 180 3 Glogovac Glogovac NNP cord-104204-pdnkabwj 180 4 , , , cord-104204-pdnkabwj 180 5 the the DT cord-104204-pdnkabwj 180 6 depth depth NN cord-104204-pdnkabwj 180 7 of of IN cord-104204-pdnkabwj 180 8 the the DT cord-104204-pdnkabwj 180 9 wells well NNS cord-104204-pdnkabwj 180 10 is be VBZ cord-104204-pdnkabwj 180 11 5 5 CD cord-104204-pdnkabwj 180 12 - - SYM cord-104204-pdnkabwj 180 13 15 15 CD cord-104204-pdnkabwj 180 14 m m NN cord-104204-pdnkabwj 180 15 , , , cord-104204-pdnkabwj 180 16 whereas whereas IN cord-104204-pdnkabwj 180 17 wells well NNS cord-104204-pdnkabwj 180 18 in in IN cord-104204-pdnkabwj 180 19 Upper Upper NNP cord-104204-pdnkabwj 180 20 Glogovac Glogovac NNP cord-104204-pdnkabwj 180 21 are be VBP cord-104204-pdnkabwj 180 22 20 20 CD cord-104204-pdnkabwj 180 23 m m NN cord-104204-pdnkabwj 180 24 or or CC cord-104204-pdnkabwj 180 25 deeper deep JJR cord-104204-pdnkabwj 180 26 . . . cord-104204-pdnkabwj 181 1 No no DT cord-104204-pdnkabwj 181 2 cases case NNS cord-104204-pdnkabwj 181 3 of of IN cord-104204-pdnkabwj 181 4 nephropathy nephropathy NN cord-104204-pdnkabwj 181 5 have have VBP cord-104204-pdnkabwj 181 6 occurred occur VBN cord-104204-pdnkabwj 181 7 in in IN cord-104204-pdnkabwj 181 8 families family NNS cord-104204-pdnkabwj 181 9 using use VBG cord-104204-pdnkabwj 181 10 water water NN cord-104204-pdnkabwj 181 11 from from IN cord-104204-pdnkabwj 181 12 wells well NNS cord-104204-pdnkabwj 181 13 deeper deeply RBR cord-104204-pdnkabwj 181 14 than than IN cord-104204-pdnkabwj 181 15 25 25 CD cord-104204-pdnkabwj 181 16 m m NN cord-104204-pdnkabwj 181 17 ( ( -LRB- cord-104204-pdnkabwj 181 18 44 44 CD cord-104204-pdnkabwj 181 19 ) ) -RRB- cord-104204-pdnkabwj 181 20 . . . cord-104204-pdnkabwj 182 1 Although although IN cord-104204-pdnkabwj 182 2 the the DT cord-104204-pdnkabwj 182 3 hydrology hydrology NN cord-104204-pdnkabwj 182 4 of of IN cord-104204-pdnkabwj 182 5 the the DT cord-104204-pdnkabwj 182 6 region region NN cord-104204-pdnkabwj 182 7 is be VBZ cord-104204-pdnkabwj 182 8 not not RB cord-104204-pdnkabwj 182 9 very very RB cord-104204-pdnkabwj 182 10 rigorously rigorously RB cord-104204-pdnkabwj 182 11 characterized characterize VBN cord-104204-pdnkabwj 182 12 , , , cord-104204-pdnkabwj 182 13 Gaon Gaon NNP cord-104204-pdnkabwj 182 14 ( ( -LRB- cord-104204-pdnkabwj 182 15 44 44 CD cord-104204-pdnkabwj 182 16 ) ) -RRB- cord-104204-pdnkabwj 183 1 hypothesized hypothesize VBN cord-104204-pdnkabwj 183 2 that that IN cord-104204-pdnkabwj 183 3 the the DT cord-104204-pdnkabwj 183 4 wells well NNS cord-104204-pdnkabwj 183 5 of of IN cord-104204-pdnkabwj 183 6 Upper Upper NNP cord-104204-pdnkabwj 183 7 Glogovac Glogovac NNP cord-104204-pdnkabwj 183 8 derive derive VBP cord-104204-pdnkabwj 183 9 water water NN cord-104204-pdnkabwj 183 10 mainly mainly RB cord-104204-pdnkabwj 183 11 from from IN cord-104204-pdnkabwj 183 12 the the DT cord-104204-pdnkabwj 183 13 mountains mountain NNS cord-104204-pdnkabwj 183 14 , , , cord-104204-pdnkabwj 183 15 whereas whereas IN cord-104204-pdnkabwj 183 16 those those DT cord-104204-pdnkabwj 183 17 from from IN cord-104204-pdnkabwj 183 18 Lower low JJR cord-104204-pdnkabwj 183 19 Glogovac Glogovac NNP cord-104204-pdnkabwj 183 20 derive derive VBP cord-104204-pdnkabwj 183 21 water water NN cord-104204-pdnkabwj 183 22 primarily primarily RB cord-104204-pdnkabwj 183 23 from from IN cord-104204-pdnkabwj 183 24 the the DT cord-104204-pdnkabwj 183 25 River River NNP cord-104204-pdnkabwj 183 26 Drina Drina NNP cord-104204-pdnkabwj 183 27 . . . cord-104204-pdnkabwj 184 1 The the DT cord-104204-pdnkabwj 184 2 Pliocene Pliocene NNP cord-104204-pdnkabwj 184 3 lignite lignite NN cord-104204-pdnkabwj 184 4 theory theory NN cord-104204-pdnkabwj 184 5 for for IN cord-104204-pdnkabwj 184 6 BEN BEN NNP cord-104204-pdnkabwj 184 7 etiology etiology NN cord-104204-pdnkabwj 184 8 was be VBD cord-104204-pdnkabwj 184 9 also also RB cord-104204-pdnkabwj 184 10 used use VBN cord-104204-pdnkabwj 184 11 in in IN cord-104204-pdnkabwj 184 12 a a DT cord-104204-pdnkabwj 184 13 predictive predictive JJ cord-104204-pdnkabwj 184 14 mode mode NN cord-104204-pdnkabwj 184 15 . . . cord-104204-pdnkabwj 185 1 A a DT cord-104204-pdnkabwj 185 2 previously previously RB cord-104204-pdnkabwj 185 3 unknown unknown JJ cord-104204-pdnkabwj 185 4 endemic endemic JJ cord-104204-pdnkabwj 185 5 area area NN cord-104204-pdnkabwj 185 6 in in IN cord-104204-pdnkabwj 185 7 southeastern southeastern JJ cord-104204-pdnkabwj 185 8 Serbia Serbia NNP cord-104204-pdnkabwj 185 9 ( ( -LRB- cord-104204-pdnkabwj 185 10 Kosovo Kosovo NNP cord-104204-pdnkabwj 185 11 region region NN cord-104204-pdnkabwj 185 12 ) ) -RRB- cord-104204-pdnkabwj 185 13 was be VBD cord-104204-pdnkabwj 185 14 described describe VBN cord-104204-pdnkabwj 185 15 based base VBN cord-104204-pdnkabwj 185 16 on on IN cord-104204-pdnkabwj 185 17 the the DT cord-104204-pdnkabwj 185 18 proximity proximity NN cord-104204-pdnkabwj 185 19 of of IN cord-104204-pdnkabwj 185 20 the the DT cord-104204-pdnkabwj 185 21 area area NN cord-104204-pdnkabwj 185 22 to to IN cord-104204-pdnkabwj 185 23 a a DT cord-104204-pdnkabwj 185 24 previously previously RB cord-104204-pdnkabwj 185 25 identified identify VBN cord-104204-pdnkabwj 185 26 Pliocene pliocene JJ cord-104204-pdnkabwj 185 27 coal coal NN cord-104204-pdnkabwj 185 28 field field NN cord-104204-pdnkabwj 185 29 ( ( -LRB- cord-104204-pdnkabwj 185 30 coal coal NN cord-104204-pdnkabwj 185 31 deposit deposit NN cord-104204-pdnkabwj 185 32 # # $ cord-104204-pdnkabwj 185 33 19 19 CD cord-104204-pdnkabwj 185 34 in in IN cord-104204-pdnkabwj 185 35 Figure figure NN cord-104204-pdnkabwj 185 36 3 3 CD cord-104204-pdnkabwj 185 37 ) ) -RRB- cord-104204-pdnkabwj 185 38 ( ( -LRB- cord-104204-pdnkabwj 185 39 5,291 5,291 CD cord-104204-pdnkabwj 185 40 . . . cord-104204-pdnkabwj 186 1 A a DT cord-104204-pdnkabwj 186 2 summary summary NN cord-104204-pdnkabwj 186 3 of of IN cord-104204-pdnkabwj 186 4 the the DT cord-104204-pdnkabwj 186 5 findings finding NNS cord-104204-pdnkabwj 186 6 that that WDT cord-104204-pdnkabwj 186 7 sustain sustain VBP cord-104204-pdnkabwj 186 8 and and CC cord-104204-pdnkabwj 186 9 disprove disprove VBP cord-104204-pdnkabwj 186 10 the the DT cord-104204-pdnkabwj 186 11 implication implication NN cord-104204-pdnkabwj 186 12 of of IN cord-104204-pdnkabwj 186 13 the the DT cord-104204-pdnkabwj 186 14 Pliocene Pliocene NNP cord-104204-pdnkabwj 186 15 lignites lignite NNS cord-104204-pdnkabwj 186 16 in in IN cord-104204-pdnkabwj 186 17 BEN BEN NNP cord-104204-pdnkabwj 186 18 and and CC cord-104204-pdnkabwj 186 19 the the DT cord-104204-pdnkabwj 186 20 future future JJ cord-104204-pdnkabwj 186 21 research research NN cord-104204-pdnkabwj 186 22 needed need VBN cord-104204-pdnkabwj 186 23 to to TO cord-104204-pdnkabwj 186 24 reinforce reinforce VB cord-104204-pdnkabwj 186 25 the the DT cord-104204-pdnkabwj 186 26 theory theory NN cord-104204-pdnkabwj 186 27 is be VBZ cord-104204-pdnkabwj 186 28 presented present VBN cord-104204-pdnkabwj 186 29 in in IN cord-104204-pdnkabwj 186 30 Table Table NNP cord-104204-pdnkabwj 186 31 2 2 CD cord-104204-pdnkabwj 186 32 . . . cord-104204-pdnkabwj 187 1 As as RB cord-104204-pdnkabwj 187 2 long long RB cord-104204-pdnkabwj 187 3 as as IN cord-104204-pdnkabwj 187 4 the the DT cord-104204-pdnkabwj 187 5 BEN BEN NNP cord-104204-pdnkabwj 187 6 etiological etiological JJ cord-104204-pdnkabwj 187 7 agent(s agent(s NNP cord-104204-pdnkabwj 187 8 ) ) -RRB- cord-104204-pdnkabwj 187 9 and and CC cord-104204-pdnkabwj 187 10 its -PRON- PRP$ cord-104204-pdnkabwj 187 11 origins origin NNS cord-104204-pdnkabwj 187 12 remain remain VBP cord-104204-pdnkabwj 187 13 unproved unproved JJ cord-104204-pdnkabwj 187 14 , , , cord-104204-pdnkabwj 187 15 it -PRON- PRP cord-104204-pdnkabwj 187 16 is be VBZ cord-104204-pdnkabwj 187 17 hard hard JJ cord-104204-pdnkabwj 187 18 to to TO cord-104204-pdnkabwj 187 19 predict predict VB cord-104204-pdnkabwj 187 20 if if IN cord-104204-pdnkabwj 187 21 the the DT cord-104204-pdnkabwj 187 22 exposure exposure NN cord-104204-pdnkabwj 187 23 to to IN cord-104204-pdnkabwj 187 24 the the DT cord-104204-pdnkabwj 187 25 nephrotoxicant nephrotoxicant NNP cord-104204-pdnkabwj 187 26 is be VBZ cord-104204-pdnkabwj 187 27 continuous continuous JJ cord-104204-pdnkabwj 187 28 or or CC cord-104204-pdnkabwj 187 29 discontinuous discontinuous JJ cord-104204-pdnkabwj 187 30 . . . cord-104204-pdnkabwj 188 1 However however RB cord-104204-pdnkabwj 188 2 , , , cord-104204-pdnkabwj 188 3 irrespective irrespective RB cord-104204-pdnkabwj 188 4 of of IN cord-104204-pdnkabwj 188 5 the the DT cord-104204-pdnkabwj 188 6 continuity continuity NN cord-104204-pdnkabwj 188 7 pattern pattern NN cord-104204-pdnkabwj 188 8 , , , cord-104204-pdnkabwj 188 9 there there EX cord-104204-pdnkabwj 188 10 seems seem VBZ cord-104204-pdnkabwj 188 11 to to TO cord-104204-pdnkabwj 188 12 be be VB cord-104204-pdnkabwj 188 13 an an DT cord-104204-pdnkabwj 188 14 aggravation aggravation NN cord-104204-pdnkabwj 188 15 of of IN cord-104204-pdnkabwj 188 16 the the DT cord-104204-pdnkabwj 188 17 disease disease NN cord-104204-pdnkabwj 188 18 symptoms symptom NNS cord-104204-pdnkabwj 188 19 and and CC cord-104204-pdnkabwj 188 20 an an DT cord-104204-pdnkabwj 188 21 increased increased JJ cord-104204-pdnkabwj 188 22 mortality mortality NN cord-104204-pdnkabwj 188 23 from from IN cord-104204-pdnkabwj 188 24 BEN BEN NNP cord-104204-pdnkabwj 188 25 in in IN cord-104204-pdnkabwj 188 26 certain certain JJ cord-104204-pdnkabwj 188 27 seasons season NNS cord-104204-pdnkabwj 188 28 , , , cord-104204-pdnkabwj 188 29 usually usually RB cord-104204-pdnkabwj 188 30 following follow VBG cord-104204-pdnkabwj 188 31 a a DT cord-104204-pdnkabwj 188 32 prolonged prolonged JJ cord-104204-pdnkabwj 188 33 rainy rainy JJ cord-104204-pdnkabwj 188 34 period period NN cord-104204-pdnkabwj 188 35 . . . cord-104204-pdnkabwj 189 1 Both both DT cord-104204-pdnkabwj 189 2 the the DT cord-104204-pdnkabwj 189 3 mycotoxin mycotoxin NN cord-104204-pdnkabwj 189 4 ( ( -LRB- cord-104204-pdnkabwj 189 5 ochratoxin ochratoxin NNP cord-104204-pdnkabwj 189 6 ) ) -RRB- cord-104204-pdnkabwj 189 7 and and CC cord-104204-pdnkabwj 189 8 the the DT cord-104204-pdnkabwj 189 9 Pliocene pliocene JJ cord-104204-pdnkabwj 189 10 lignite lignite NN cord-104204-pdnkabwj 189 11 hypotheses hypothesis NNS cord-104204-pdnkabwj 189 12 can can MD cord-104204-pdnkabwj 189 13 explain explain VB cord-104204-pdnkabwj 189 14 this this DT cord-104204-pdnkabwj 189 15 seasonal seasonal JJ cord-104204-pdnkabwj 189 16 variation variation NN cord-104204-pdnkabwj 189 17 , , , cord-104204-pdnkabwj 189 18 the the DT cord-104204-pdnkabwj 189 19 former former JJ cord-104204-pdnkabwj 189 20 by by IN cord-104204-pdnkabwj 189 21 an an DT cord-104204-pdnkabwj 189 22 increased increase VBN cord-104204-pdnkabwj 189 23 growth growth NN cord-104204-pdnkabwj 189 24 of of IN cord-104204-pdnkabwj 189 25 fungi fungus NNS cord-104204-pdnkabwj 189 26 and and CC cord-104204-pdnkabwj 189 27 OTA ota NN cord-104204-pdnkabwj 189 28 production production NN cord-104204-pdnkabwj 189 29 in in IN cord-104204-pdnkabwj 189 30 foodstuffs foodstuff NNS cord-104204-pdnkabwj 189 31 in in IN cord-104204-pdnkabwj 189 32 the the DT cord-104204-pdnkabwj 189 33 humid humid JJ cord-104204-pdnkabwj 189 34 , , , cord-104204-pdnkabwj 189 35 high high JJ cord-104204-pdnkabwj 189 36 water water NN cord-104204-pdnkabwj 189 37 activity activity NN cord-104204-pdnkabwj 189 38 periods period NNS cord-104204-pdnkabwj 189 39 , , , cord-104204-pdnkabwj 189 40 and and CC cord-104204-pdnkabwj 189 41 the the DT cord-104204-pdnkabwj 189 42 latter latter JJ cord-104204-pdnkabwj 189 43 by by IN cord-104204-pdnkabwj 189 44 an an DT cord-104204-pdnkabwj 189 45 accelerated accelerated JJ cord-104204-pdnkabwj 189 46 weathering weathering NN cord-104204-pdnkabwj 189 47 of of IN cord-104204-pdnkabwj 189 48 the the DT cord-104204-pdnkabwj 189 49 coal coal NN cord-104204-pdnkabwj 189 50 deposits deposit NNS cord-104204-pdnkabwj 189 51 during during IN cord-104204-pdnkabwj 189 52 the the DT cord-104204-pdnkabwj 189 53 rainy rainy JJ cord-104204-pdnkabwj 189 54 season season NN cord-104204-pdnkabwj 189 55 , , , cord-104204-pdnkabwj 189 56 increasing increase VBG cord-104204-pdnkabwj 189 57 the the DT cord-104204-pdnkabwj 189 58 concentration concentration NN cord-104204-pdnkabwj 189 59 of of IN cord-104204-pdnkabwj 189 60 the the DT cord-104204-pdnkabwj 189 61 weathered weathered JJ cord-104204-pdnkabwj 189 62 compounds compound NNS cord-104204-pdnkabwj 189 63 into into IN cord-104204-pdnkabwj 189 64 the the DT cord-104204-pdnkabwj 189 65 ground ground NN cord-104204-pdnkabwj 189 66 and and CC cord-104204-pdnkabwj 189 67 well well JJ cord-104204-pdnkabwj 189 68 water water NN cord-104204-pdnkabwj 189 69 . . . cord-104204-pdnkabwj 190 1 An an DT cord-104204-pdnkabwj 190 2 acute acute JJ cord-104204-pdnkabwj 190 3 exposure exposure NN cord-104204-pdnkabwj 190 4 to to IN cord-104204-pdnkabwj 190 5 higher high JJR cord-104204-pdnkabwj 190 6 concentrations concentration NNS cord-104204-pdnkabwj 190 7 of of IN cord-104204-pdnkabwj 190 8 the the DT cord-104204-pdnkabwj 190 9 nephrotoxic nephrotoxic NNP cord-104204-pdnkabwj 190 10 molecules molecule NNS cord-104204-pdnkabwj 190 11 will will MD cord-104204-pdnkabwj 190 12 exhaust exhaust VB cord-104204-pdnkabwj 190 13 the the DT cord-104204-pdnkabwj 190 14 functional functional JJ cord-104204-pdnkabwj 190 15 CJ CJ NNP cord-104204-pdnkabwj 190 16 * * NFP cord-104204-pdnkabwj 190 17 ¶~J~'c ¶~j~'c NN cord-104204-pdnkabwj 190 18 2 2 CD cord-104204-pdnkabwj 190 19 . . . cord-104204-pdnkabwj 190 20 ' ' '' cord-104204-pdnkabwj 191 1 xr xr NNP cord-104204-pdnkabwj 191 2 .>V .>V . cord-104204-pdnkabwj 192 1 r r LS cord-104204-pdnkabwj 192 2 ... ... : cord-104204-pdnkabwj 192 3 C. C. NNP cord-104204-pdnkabwj 192 4 .Y .Y . cord-104204-pdnkabwj 193 1 MC,~~~~~~~~F mc,~~~~~~~~f UH cord-104204-pdnkabwj 193 2 igure igure NNP cord-104204-pdnkabwj 193 3 7 7 CD cord-104204-pdnkabwj 193 4 . . . cord-104204-pdnkabwj 194 1 Solid solid JJ cord-104204-pdnkabwj 194 2 state state NN cord-104204-pdnkabwj 194 3 13C 13c CD cord-104204-pdnkabwj 194 4 nuclear nuclear JJ cord-104204-pdnkabwj 194 5 magnetic magnetic JJ cord-104204-pdnkabwj 194 6 resonance resonance NN cord-104204-pdnkabwj 194 7 ( ( -LRB- cord-104204-pdnkabwj 194 8 NI NI NNP cord-104204-pdnkabwj 194 9 distilled distil VBN cord-104204-pdnkabwj 194 10 water water NN cord-104204-pdnkabwj 194 11 leachates leachate NNS cord-104204-pdnkabwj 194 12 of of IN cord-104204-pdnkabwj 194 13 two two CD cord-104204-pdnkabwj 194 14 Pliocene Pliocene NNP cord-104204-pdnkabwj 194 15 ignites ignite VBZ cord-104204-pdnkabwj 194 16 from from IN cord-104204-pdnkabwj 194 17 E E NNS cord-104204-pdnkabwj 194 18 of of IN cord-104204-pdnkabwj 194 19 the the DT cord-104204-pdnkabwj 194 20 former former JJ cord-104204-pdnkabwj 194 21 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 194 22 and and CC cord-104204-pdnkabwj 194 23 a a DT cord-104204-pdnkabwj 194 24 North North NNP cord-104204-pdnkabwj 194 25 Dakota Dakota NNP cord-104204-pdnkabwj 194 26 lignite lignite NN cord-104204-pdnkabwj 194 27 . . . cord-104204-pdnkabwj 195 1 The the DT cord-104204-pdnkabwj 195 2 characterized characterize VBN cord-104204-pdnkabwj 195 3 by by IN cord-104204-pdnkabwj 195 4 a a DT cord-104204-pdnkabwj 195 5 high high JJ cord-104204-pdnkabwj 195 6 degree degree NN cord-104204-pdnkabwj 195 7 of of IN cord-104204-pdnkabwj 195 8 aliphatic aliphatic JJ cord-104204-pdnkabwj 195 9 hydrocarb hydrocarb NN cord-104204-pdnkabwj 195 10 and and CC cord-104204-pdnkabwj 195 11 aromatic aromatic JJ cord-104204-pdnkabwj 195 12 ( ( -LRB- cord-104204-pdnkabwj 195 13 1 1 CD cord-104204-pdnkabwj 195 14 10 10 CD cord-104204-pdnkabwj 195 15 - - SYM cord-104204-pdnkabwj 195 16 150 150 CD cord-104204-pdnkabwj 195 17 ppm ppm NN cord-104204-pdnkabwj 195 18 ) ) -RRB- cord-104204-pdnkabwj 195 19 and and CC cord-104204-pdnkabwj 195 20 carboxyl carboxyl NN cord-104204-pdnkabwj 195 21 ( ( -LRB- cord-104204-pdnkabwj 195 22 175 175 CD cord-104204-pdnkabwj 195 23 ppm ppm NN cord-104204-pdnkabwj 195 24 ) ) -RRB- cord-104204-pdnkabwj 195 25 stru4 stru4 NN cord-104204-pdnkabwj 195 26 reserve reserve NN cord-104204-pdnkabwj 195 27 of of IN cord-104204-pdnkabwj 195 28 the the DT cord-104204-pdnkabwj 195 29 kidney kidney NN cord-104204-pdnkabwj 195 30 , , , cord-104204-pdnkabwj 195 31 causing cause VBG cord-104204-pdnkabwj 195 32 the the DT cord-104204-pdnkabwj 195 33 disease disease NN cord-104204-pdnkabwj 195 34 to to TO cord-104204-pdnkabwj 195 35 evolve evolve VB cord-104204-pdnkabwj 195 36 from from IN cord-104204-pdnkabwj 195 37 the the DT cord-104204-pdnkabwj 195 38 asymptomatic asymptomatic JJ cord-104204-pdnkabwj 195 39 to to IN cord-104204-pdnkabwj 195 40 the the DT cord-104204-pdnkabwj 195 41 symptomatic symptomatic JJ cord-104204-pdnkabwj 195 42 phase phase NN cord-104204-pdnkabwj 195 43 of of IN cord-104204-pdnkabwj 195 44 the the DT cord-104204-pdnkabwj 195 45 renal renal JJ cord-104204-pdnkabwj 195 46 failure failure NN cord-104204-pdnkabwj 195 47 . . . cord-104204-pdnkabwj 196 1 The the DT cord-104204-pdnkabwj 196 2 initial initial JJ cord-104204-pdnkabwj 196 3 description description NN cord-104204-pdnkabwj 196 4 of of IN cord-104204-pdnkabwj 196 5 a a DT cord-104204-pdnkabwj 196 6 high high JJ cord-104204-pdnkabwj 196 7 incidence incidence NN cord-104204-pdnkabwj 196 8 of of IN cord-104204-pdnkabwj 196 9 UTT UTT NNP cord-104204-pdnkabwj 196 10 in in IN cord-104204-pdnkabwj 196 11 BEN BEN NNP cord-104204-pdnkabwj 196 12 patients patient NNS cord-104204-pdnkabwj 196 13 soon soon RB cord-104204-pdnkabwj 196 14 led lead VBD cord-104204-pdnkabwj 196 15 to to IN cord-104204-pdnkabwj 196 16 the the DT cord-104204-pdnkabwj 196 17 suspicion suspicion NN cord-104204-pdnkabwj 196 18 that that IN cord-104204-pdnkabwj 196 19 the the DT cord-104204-pdnkabwj 196 20 nephropathy nephropathy NN cord-104204-pdnkabwj 196 21 and and CC cord-104204-pdnkabwj 196 22 urinary urinary JJ cord-104204-pdnkabwj 196 23 tract tract NN cord-104204-pdnkabwj 196 24 oncoge-:.ii oncoge-:.ii NNS cord-104204-pdnkabwj 196 25 , , , cord-104204-pdnkabwj 196 26 nesis nesis NNP cord-104204-pdnkabwj 196 27 were be VBD cord-104204-pdnkabwj 196 28 causally causally RB cord-104204-pdnkabwj 196 29 related relate VBN cord-104204-pdnkabwj 196 30 . . . cord-104204-pdnkabwj 197 1 , , , cord-104204-pdnkabwj 197 2 Rare rare JJ cord-104204-pdnkabwj 197 3 patients patient NNS cord-104204-pdnkabwj 197 4 over over IN cord-104204-pdnkabwj 197 5 50 50 CD cord-104204-pdnkabwj 197 6 - - SYM cord-104204-pdnkabwj 197 7 60 60 CD cord-104204-pdnkabwj 197 8 years year NNS cord-104204-pdnkabwj 197 9 of of IN cord-104204-pdnkabwj 197 10 age age NN cord-104204-pdnkabwj 197 11 ( ( -LRB- cord-104204-pdnkabwj 197 12 on on IN cord-104204-pdnkabwj 197 13 average average JJ cord-104204-pdnkabwj 197 14 , , , cord-104204-pdnkabwj 197 15 10 10 CD cord-104204-pdnkabwj 197 16 years year NNS cord-104204-pdnkabwj 197 17 earlier early RBR cord-104204-pdnkabwj 197 18 than than IN cord-104204-pdnkabwj 197 19 UTTs utt NNS cord-104204-pdnkabwj 197 20 diagnosed diagnose VBN cord-104204-pdnkabwj 197 21 in in IN cord-104204-pdnkabwj 197 22 the the DT cord-104204-pdnkabwj 197 23 general general JJ cord-104204-pdnkabwj 197 24 population population NN cord-104204-pdnkabwj 197 25 from from IN cord-104204-pdnkabwj 197 26 the the DT cord-104204-pdnkabwj 197 27 nonendemic nonendemic NNP cord-104204-pdnkabwj 197 28 regions region NNS cord-104204-pdnkabwj 197 29 ) ) -RRB- cord-104204-pdnkabwj 197 30 ( ( -LRB- cord-104204-pdnkabwj 197 31 45 45 CD cord-104204-pdnkabwj 197 32 ) ) -RRB- cord-104204-pdnkabwj 197 33 . . . cord-104204-pdnkabwj 198 1 Moreover moreover RB cord-104204-pdnkabwj 198 2 , , , cord-104204-pdnkabwj 198 3 compared compare VBN cord-104204-pdnkabwj 198 4 to to IN cord-104204-pdnkabwj 198 5 the the DT cord-104204-pdnkabwj 198 6 general general JJ cord-104204-pdnkabwj 198 7 population population NN cord-104204-pdnkabwj 198 8 in in IN cord-104204-pdnkabwj 198 9 which which WDT cord-104204-pdnkabwj 198 10 UTTs utt NNS cord-104204-pdnkabwj 198 11 are be VBP cord-104204-pdnkabwj 198 12 encountered encounter VBN cord-104204-pdnkabwj 198 13 three three CD cord-104204-pdnkabwj 198 14 to to TO cord-104204-pdnkabwj 198 15 five five CD cord-104204-pdnkabwj 198 16 times time NNS cord-104204-pdnkabwj 198 17 more more RBR cord-104204-pdnkabwj 198 18 frequently frequently RB cord-104204-pdnkabwj 198 19 in in IN cord-104204-pdnkabwj 198 20 males male NNS cord-104204-pdnkabwj 198 21 , , , cord-104204-pdnkabwj 198 22 the the DT cord-104204-pdnkabwj 198 23 sex sex NN cord-104204-pdnkabwj 198 24 ratio ratio NN cord-104204-pdnkabwj 198 25 of of IN cord-104204-pdnkabwj 198 26 UTT UTT NNP cord-104204-pdnkabwj 198 27 occurrence occurrence NN cord-104204-pdnkabwj 198 28 in in IN cord-104204-pdnkabwj 198 29 BEN BEN NNP cord-104204-pdnkabwj 198 30 equals equal VBZ cord-104204-pdnkabwj 198 31 1 1 CD cord-104204-pdnkabwj 198 32 or or CC cord-104204-pdnkabwj 198 33 is be VBZ cord-104204-pdnkabwj 198 34 slightly slightly RB cord-104204-pdnkabwj 198 35 reversed reverse VBN cord-104204-pdnkabwj 198 36 , , , cord-104204-pdnkabwj 198 37 with with IN cord-104204-pdnkabwj 198 38 women woman NNS cord-104204-pdnkabwj 198 39 being be VBG cord-104204-pdnkabwj 198 40 more more RBR cord-104204-pdnkabwj 198 41 frequently frequently RB cord-104204-pdnkabwj 198 42 affected affect VBN cord-104204-pdnkabwj 198 43 ( ( -LRB- cord-104204-pdnkabwj 198 44 46 46 CD cord-104204-pdnkabwj 198 45 ) ) -RRB- cord-104204-pdnkabwj 198 46 . . . cord-104204-pdnkabwj 199 1 This this DT cord-104204-pdnkabwj 199 2 could could MD cord-104204-pdnkabwj 199 3 reflect reflect VB cord-104204-pdnkabwj 199 4 the the DT cord-104204-pdnkabwj 199 5 overall overall JJ cord-104204-pdnkabwj 199 6 higher high JJR cord-104204-pdnkabwj 199 7 incidence incidence NN cord-104204-pdnkabwj 199 8 of of IN cord-104204-pdnkabwj 199 9 BEN BEN NNP cord-104204-pdnkabwj 199 10 in in IN cord-104204-pdnkabwj 199 11 women woman NNS cord-104204-pdnkabwj 199 12 , , , cord-104204-pdnkabwj 199 13 but but CC cord-104204-pdnkabwj 199 14 also also RB cord-104204-pdnkabwj 199 15 a a DT cord-104204-pdnkabwj 199 16 particular particular JJ cord-104204-pdnkabwj 199 17 ( ( -LRB- cord-104204-pdnkabwj 199 18 hormonal hormonal JJ cord-104204-pdnkabwj 199 19 , , , cord-104204-pdnkabwj 199 20 etc etc FW cord-104204-pdnkabwj 199 21 . . . cord-104204-pdnkabwj 199 22 ) ) -RRB- cord-104204-pdnkabwj 200 1 susceptibility susceptibility NN cord-104204-pdnkabwj 200 2 not not RB cord-104204-pdnkabwj 200 3 encountered encounter VBN cord-104204-pdnkabwj 200 4 in in IN cord-104204-pdnkabwj 200 5 men man NNS cord-104204-pdnkabwj 200 6 . . . cord-104204-pdnkabwj 201 1 The the DT cord-104204-pdnkabwj 201 2 sporadic sporadic JJ cord-104204-pdnkabwj 201 3 association association NN cord-104204-pdnkabwj 201 4 between between IN cord-104204-pdnkabwj 201 5 BEN BEN NNP cord-104204-pdnkabwj 201 6 and and CC cord-104204-pdnkabwj 201 7 UTTs UTTs NNP cord-104204-pdnkabwj 201 8 could could MD cord-104204-pdnkabwj 201 9 be be VB cord-104204-pdnkabwj 201 10 explained explain VBN cord-104204-pdnkabwj 201 11 by by IN cord-104204-pdnkabwj 201 12 idiosyncratic idiosyncratic JJ cord-104204-pdnkabwj 201 13 susceptibility susceptibility NN cord-104204-pdnkabwj 201 14 , , , cord-104204-pdnkabwj 201 15 ethnic ethnic JJ cord-104204-pdnkabwj 201 16 behavioral behavioral JJ cord-104204-pdnkabwj 201 17 differences difference NNS cord-104204-pdnkabwj 201 18 ( ( -LRB- cord-104204-pdnkabwj 201 19 e.g. e.g. RB cord-104204-pdnkabwj 201 20 , , , cord-104204-pdnkabwj 201 21 hydration hydration NN cord-104204-pdnkabwj 201 22 patterns pattern NNS cord-104204-pdnkabwj 201 23 and and CC cord-104204-pdnkabwj 201 24 food food NN cord-104204-pdnkabwj 201 25 preparation preparation NN cord-104204-pdnkabwj 201 26 habits habit NNS cord-104204-pdnkabwj 201 27 ) ) -RRB- cord-104204-pdnkabwj 201 28 , , , cord-104204-pdnkabwj 201 29 and/or and/or CC cord-104204-pdnkabwj 201 30 the the DT cord-104204-pdnkabwj 201 31 action action NN cord-104204-pdnkabwj 201 32 of of IN cord-104204-pdnkabwj 201 33 environmental environmental JJ cord-104204-pdnkabwj 201 34 cofactors cofactor NNS cord-104204-pdnkabwj 201 35 ( ( -LRB- cord-104204-pdnkabwj 201 36 e.g. e.g. RB cord-104204-pdnkabwj 201 37 , , , cord-104204-pdnkabwj 201 38 selenium selenium NN cord-104204-pdnkabwj 201 39 deficiency deficiency NN cord-104204-pdnkabwj 201 40 in in IN cord-104204-pdnkabwj 201 41 Serbia Serbia NNP cord-104204-pdnkabwj 201 42 , , , cord-104204-pdnkabwj 201 43 which which WDT cord-104204-pdnkabwj 201 44 is be VBZ cord-104204-pdnkabwj 201 45 unevenly unevenly RB cord-104204-pdnkabwj 201 46 distributed distribute VBN cord-104204-pdnkabwj 201 47 in in IN cord-104204-pdnkabwj 201 48 the the DT cord-104204-pdnkabwj 201 49 endemic endemic JJ cord-104204-pdnkabwj 201 50 regions region NNS cord-104204-pdnkabwj 201 51 ) ) -RRB- cord-104204-pdnkabwj 201 52 . . . cord-104204-pdnkabwj 202 1 Phenotypic phenotypic JJ cord-104204-pdnkabwj 202 2 and and CC cord-104204-pdnkabwj 202 3 genotypic genotypic JJ cord-104204-pdnkabwj 202 4 differences difference NNS cord-104204-pdnkabwj 202 5 in in IN cord-104204-pdnkabwj 202 6 a a DT cord-104204-pdnkabwj 202 7 number number NN cord-104204-pdnkabwj 202 8 of of IN cord-104204-pdnkabwj 202 9 activating activate VBG cord-104204-pdnkabwj 202 10 and and CC cord-104204-pdnkabwj 202 11 detoxifying detoxify VBG cord-104204-pdnkabwj 202 12 enzymes enzyme NNS cord-104204-pdnkabwj 202 13 have have VBP cord-104204-pdnkabwj 202 14 been be VBN cord-104204-pdnkabwj 202 15 frequendy frequendy VBN cord-104204-pdnkabwj 202 16 linked link VBN cord-104204-pdnkabwj 202 17 to to IN cord-104204-pdnkabwj 202 18 individualized individualized JJ cord-104204-pdnkabwj 202 19 susceptibility susceptibility NN cord-104204-pdnkabwj 202 20 to to IN cord-104204-pdnkabwj 202 21 certain certain JJ cord-104204-pdnkabwj 202 22 forms form NNS cord-104204-pdnkabwj 202 23 of of IN cord-104204-pdnkabwj 202 24 cancer cancer NN cord-104204-pdnkabwj 202 25 ( ( -LRB- cord-104204-pdnkabwj 202 26 47 47 CD cord-104204-pdnkabwj 202 27 , , , cord-104204-pdnkabwj 202 28 48 48 CD cord-104204-pdnkabwj 202 29 ) ) -RRB- cord-104204-pdnkabwj 202 30 . . . cord-104204-pdnkabwj 203 1 Related relate VBN cord-104204-pdnkabwj 203 2 to to IN cord-104204-pdnkabwj 203 3 this this DT cord-104204-pdnkabwj 203 4 constitutional constitutional JJ cord-104204-pdnkabwj 203 5 susceptibility susceptibility NN cord-104204-pdnkabwj 203 6 , , , cord-104204-pdnkabwj 203 7 interindividual interindividual JJ cord-104204-pdnkabwj 203 8 variations variation NNS cord-104204-pdnkabwj 203 9 in in IN cord-104204-pdnkabwj 203 10 the the DT cord-104204-pdnkabwj 203 11 genes gene NNS cord-104204-pdnkabwj 203 12 encoding encode VBG cord-104204-pdnkabwj 203 13 cytochromes cytochromes NNP cord-104204-pdnkabwj 203 14 P450 P450 NNP cord-104204-pdnkabwj 203 15 , , , cord-104204-pdnkabwj 203 16 such such JJ cord-104204-pdnkabwj 203 17 as as IN cord-104204-pdnkabwj 203 18 CYPIAJ CYPIAJ NNP cord-104204-pdnkabwj 203 19 , , , cord-104204-pdnkabwj 203 20 CYP2D6 CYP2D6 NNP cord-104204-pdnkabwj 203 21 , , , cord-104204-pdnkabwj 203 22 CYP2E1 CYP2E1 NNP cord-104204-pdnkabwj 203 23 , , , cord-104204-pdnkabwj 203 24 and and CC cord-104204-pdnkabwj 203 25 polymorphisms polymorphism NNS cord-104204-pdnkabwj 203 26 in in IN cord-104204-pdnkabwj 203 27 glutathione glutathione NN cord-104204-pdnkabwj 203 28 Swtransferases Swtransferases NNP cord-104204-pdnkabwj 203 29 and and CC cord-104204-pdnkabwj 203 30 N N NNP cord-104204-pdnkabwj 203 31 - - HYPH cord-104204-pdnkabwj 203 32 acetyl acetyl NN cord-104204-pdnkabwj 203 33 transferases transferase NNS cord-104204-pdnkabwj 203 34 1 1 CD cord-104204-pdnkabwj 203 35 and and CC cord-104204-pdnkabwj 203 36 2 2 CD cord-104204-pdnkabwj 203 37 are be VBP cord-104204-pdnkabwj 203 38 well well RB cord-104204-pdnkabwj 203 39 described describe VBN cord-104204-pdnkabwj 203 40 . . . cord-104204-pdnkabwj 204 1 A a DT cord-104204-pdnkabwj 204 2 clinically clinically RB cord-104204-pdnkabwj 204 3 useful useful JJ cord-104204-pdnkabwj 204 4 marker marker NN cord-104204-pdnkabwj 204 5 of of IN cord-104204-pdnkabwj 204 6 the the DT cord-104204-pdnkabwj 204 7 interindividual interindividual JJ cord-104204-pdnkabwj 204 8 variation variation NN cord-104204-pdnkabwj 204 9 in in IN cord-104204-pdnkabwj 204 10 susceptibility susceptibility NN cord-104204-pdnkabwj 204 11 to to IN cord-104204-pdnkabwj 204 12 xenobiotics xenobiotic NNS cord-104204-pdnkabwj 204 13 is be VBZ cord-104204-pdnkabwj 204 14 the the DT cord-104204-pdnkabwj 204 15 efficiency efficiency NN cord-104204-pdnkabwj 204 16 of of IN cord-104204-pdnkabwj 204 17 debrisoquine debrisoquine NN cord-104204-pdnkabwj 204 18 metabolism metabolism NN cord-104204-pdnkabwj 204 19 . . . cord-104204-pdnkabwj 205 1 Administered administer VBN cord-104204-pdnkabwj 205 2 in in IN cord-104204-pdnkabwj 205 3 healthy healthy JJ cord-104204-pdnkabwj 205 4 individuals individual NNS cord-104204-pdnkabwj 205 5 , , , cord-104204-pdnkabwj 205 6 debrisoquine debrisoquine NNP cord-104204-pdnkabwj 205 7 is be VBZ cord-104204-pdnkabwj 205 8 converted convert VBN cord-104204-pdnkabwj 205 9 into into IN cord-104204-pdnkabwj 205 10 a a DT cord-104204-pdnkabwj 205 11 4hydroxy 4hydroxy CD cord-104204-pdnkabwj 205 12 derivative derivative NN cord-104204-pdnkabwj 205 13 by by IN cord-104204-pdnkabwj 205 14 debrisoquine debrisoquine NN cord-104204-pdnkabwj 205 15 hydroxylase hydroxylase NN cord-104204-pdnkabwj 205 16 ( ( -LRB- cord-104204-pdnkabwj 205 17 CYP2D6 CYP2D6 NNP cord-104204-pdnkabwj 205 18 ) ) -RRB- cord-104204-pdnkabwj 205 19 . . . cord-104204-pdnkabwj 206 1 Polymorphisms polymorphism NNS cord-104204-pdnkabwj 206 2 in in IN cord-104204-pdnkabwj 206 3 CYP2D6 cyp2d6 JJ cord-104204-pdnkabwj 206 4 genes gene NNS cord-104204-pdnkabwj 206 5 resulting result VBG cord-104204-pdnkabwj 206 6 in in IN cord-104204-pdnkabwj 206 7 impaired impaired JJ cord-104204-pdnkabwj 206 8 debrisoquine debrisoquine NN cord-104204-pdnkabwj 206 9 metabolism metabolism NN cord-104204-pdnkabwj 206 10 occur occur VBP cord-104204-pdnkabwj 206 11 in in IN cord-104204-pdnkabwj 206 12 less less JJR cord-104204-pdnkabwj 206 13 than than IN cord-104204-pdnkabwj 206 14 10 10 CD cord-104204-pdnkabwj 206 15 % % NN cord-104204-pdnkabwj 206 16 of of IN cord-104204-pdnkabwj 206 17 the the DT cord-104204-pdnkabwj 206 18 Caucasian caucasian JJ cord-104204-pdnkabwj 206 19 populations population NNS cord-104204-pdnkabwj 206 20 and and CC cord-104204-pdnkabwj 206 21 have have VBP cord-104204-pdnkabwj 206 22 been be VBN cord-104204-pdnkabwj 206 23 associated associate VBN cord-104204-pdnkabwj 206 24 with with IN cord-104204-pdnkabwj 206 25 variable variable JJ cord-104204-pdnkabwj 206 26 susceptibility susceptibility NN cord-104204-pdnkabwj 206 27 to to IN cord-104204-pdnkabwj 206 28 chemical chemical JJ cord-104204-pdnkabwj 206 29 carcinogenesis carcinogenesis NN cord-104204-pdnkabwj 206 30 ( ( -LRB- cord-104204-pdnkabwj 206 31 bladder bladder NN cord-104204-pdnkabwj 206 32 cancer cancer NN cord-104204-pdnkabwj 206 33 , , , cord-104204-pdnkabwj 206 34 leukemias leukemias RB cord-104204-pdnkabwj 206 35 , , , cord-104204-pdnkabwj 206 36 and and CC cord-104204-pdnkabwj 206 37 possibly possibly RB cord-104204-pdnkabwj 206 38 melanomas melanoma NNS cord-104204-pdnkabwj 206 39 ) ) -RRB- cord-104204-pdnkabwj 206 40 , , , cord-104204-pdnkabwj 206 41 pesticide pesticide NN cord-104204-pdnkabwj 206 42 - - HYPH cord-104204-pdnkabwj 206 43 induced induce VBN cord-104204-pdnkabwj 206 44 Parkinson Parkinson NNP cord-104204-pdnkabwj 206 45 disease disease NN cord-104204-pdnkabwj 206 46 , , , cord-104204-pdnkabwj 206 47 and and CC cord-104204-pdnkabwj 206 48 iatrogenic iatrogenic JJ cord-104204-pdnkabwj 206 49 reactions reaction NNS cord-104204-pdnkabwj 206 50 to to IN cord-104204-pdnkabwj 206 51 drugs drug NNS cord-104204-pdnkabwj 206 52 ( ( -LRB- cord-104204-pdnkabwj 206 53 49 49 CD cord-104204-pdnkabwj 206 54 ) ) -RRB- cord-104204-pdnkabwj 206 55 . . . cord-104204-pdnkabwj 207 1 The the DT cord-104204-pdnkabwj 207 2 association association NN cord-104204-pdnkabwj 207 3 between between IN cord-104204-pdnkabwj 207 4 the the DT cord-104204-pdnkabwj 207 5 efficiency efficiency NN cord-104204-pdnkabwj 207 6 of of IN cord-104204-pdnkabwj 207 7 oxidative oxidative JJ cord-104204-pdnkabwj 207 8 metabolism metabolism NN cord-104204-pdnkabwj 207 9 of of IN cord-104204-pdnkabwj 207 10 debrisoquine debrisoquine NN cord-104204-pdnkabwj 207 11 and and CC cord-104204-pdnkabwj 207 12 the the DT cord-104204-pdnkabwj 207 13 risk risk NN cord-104204-pdnkabwj 207 14 for for IN cord-104204-pdnkabwj 207 15 developing develop VBG cord-104204-pdnkabwj 207 16 BEN BEN NNP cord-104204-pdnkabwj 207 17 and/or and/or CC cord-104204-pdnkabwj 207 18 UTT UTT NNP cord-104204-pdnkabwj 207 19 was be VBD cord-104204-pdnkabwj 207 20 examined examine VBN cord-104204-pdnkabwj 207 21 in in IN cord-104204-pdnkabwj 207 22 Bulgaria Bulgaria NNP cord-104204-pdnkabwj 207 23 ( ( -LRB- cord-104204-pdnkabwj 207 24 50 50 CD cord-104204-pdnkabwj 207 25 ) ) -RRB- cord-104204-pdnkabwj 207 26 . . . cord-104204-pdnkabwj 208 1 This this DT cord-104204-pdnkabwj 208 2 study study NN cord-104204-pdnkabwj 208 3 included include VBD cord-104204-pdnkabwj 208 4 individuals individual NNS cord-104204-pdnkabwj 208 5 with with IN cord-104204-pdnkabwj 208 6 BEN BEN NNP cord-104204-pdnkabwj 208 7 and/or and/or CC cord-104204-pdnkabwj 208 8 UTT UTT NNP cord-104204-pdnkabwj 208 9 ( ( -LRB- cord-104204-pdnkabwj 208 10 both both DT cord-104204-pdnkabwj 208 11 categories category NNS cord-104204-pdnkabwj 208 12 from from IN cord-104204-pdnkabwj 208 13 the the DT cord-104204-pdnkabwj 208 14 endemic endemic JJ cord-104204-pdnkabwj 208 15 region region NN cord-104204-pdnkabwj 208 16 ) ) -RRB- cord-104204-pdnkabwj 208 17 , , , cord-104204-pdnkabwj 208 18 individuals individual NNS cord-104204-pdnkabwj 208 19 suspected suspect VBN cord-104204-pdnkabwj 208 20 of of IN cord-104204-pdnkabwj 208 21 having have VBG cord-104204-pdnkabwj 208 22 BEN BEN NNP cord-104204-pdnkabwj 208 23 , , , cord-104204-pdnkabwj 208 24 healthy healthy JJ cord-104204-pdnkabwj 208 25 controls control NNS cord-104204-pdnkabwj 208 26 from from IN cord-104204-pdnkabwj 208 27 the the DT cord-104204-pdnkabwj 208 28 endemic endemic JJ cord-104204-pdnkabwj 208 29 regions region NNS cord-104204-pdnkabwj 208 30 , , , cord-104204-pdnkabwj 208 31 and and CC cord-104204-pdnkabwj 208 32 healthy healthy JJ cord-104204-pdnkabwj 208 33 controls control NNS cord-104204-pdnkabwj 208 34 from from IN cord-104204-pdnkabwj 208 35 nonendemic nonendemic NNP cord-104204-pdnkabwj 208 36 regions region NNS cord-104204-pdnkabwj 208 37 . . . cord-104204-pdnkabwj 209 1 The the DT cord-104204-pdnkabwj 209 2 extensive extensive JJ cord-104204-pdnkabwj 209 3 metabolizer metabolizer NN cord-104204-pdnkabwj 209 4 phenotype phenotype NN cord-104204-pdnkabwj 209 5 was be VBD cord-104204-pdnkabwj 209 6 encountered encounter VBN cord-104204-pdnkabwj 209 7 in in IN cord-104204-pdnkabwj 209 8 most most JJS cord-104204-pdnkabwj 209 9 of of IN cord-104204-pdnkabwj 209 10 the the DT cord-104204-pdnkabwj 209 11 BEN BEN NNP cord-104204-pdnkabwj 209 12 cases case NNS cord-104204-pdnkabwj 209 13 and and CC cord-104204-pdnkabwj 209 14 subjects subject NNS cord-104204-pdnkabwj 209 15 with with IN cord-104204-pdnkabwj 209 16 BEN BEN NNP cord-104204-pdnkabwj 209 17 and and CC cord-104204-pdnkabwj 209 18 UTT UTT NNP cord-104204-pdnkabwj 209 19 . . . cord-104204-pdnkabwj 210 1 The the DT cord-104204-pdnkabwj 210 2 mean mean JJ cord-104204-pdnkabwj 210 3 metabolic metabolic JJ cord-104204-pdnkabwj 210 4 ratio ratio NN cord-104204-pdnkabwj 210 5 ( ( -LRB- cord-104204-pdnkabwj 210 6 unmodified unmodified JJ cord-104204-pdnkabwj 210 7 debrisoquine debrisoquine NN cord-104204-pdnkabwj 210 8 : : : cord-104204-pdnkabwj 210 9 hydroxylated hydroxylated NNP cord-104204-pdnkabwj 210 10 debrisoquine debrisoquine NNP cord-104204-pdnkabwj 210 11 ) ) -RRB- cord-104204-pdnkabwj 210 12 decreased decrease VBD cord-104204-pdnkabwj 210 13 progressively progressively RB cord-104204-pdnkabwj 210 14 as as IN cord-104204-pdnkabwj 210 15 follows follow VBZ cord-104204-pdnkabwj 210 16 : : : cord-104204-pdnkabwj 210 17 controls control NNS cord-104204-pdnkabwj 210 18 from from IN cord-104204-pdnkabwj 210 19 nonendemic nonendemic NNP cord-104204-pdnkabwj 210 20 regions region NNS cord-104204-pdnkabwj 210 21 > > XX cord-104204-pdnkabwj 210 22 controls control NNS cord-104204-pdnkabwj 210 23 from from IN cord-104204-pdnkabwj 210 24 endemic endemic JJ cord-104204-pdnkabwj 210 25 villages village NNS cord-104204-pdnkabwj 210 26 > > XX cord-104204-pdnkabwj 210 27 suspected suspect VBN cord-104204-pdnkabwj 210 28 BEN BEN NNP cord-104204-pdnkabwj 210 29 patients patient NNS cord-104204-pdnkabwj 210 30 > > IN cord-104204-pdnkabwj 210 31 BEN BEN NNP cord-104204-pdnkabwj 210 32 patients patient NNS cord-104204-pdnkabwj 210 33 . . . cord-104204-pdnkabwj 211 1 The the DT cord-104204-pdnkabwj 211 2 following follow VBG cord-104204-pdnkabwj 211 3 condusion condusion NN cord-104204-pdnkabwj 211 4 can can MD cord-104204-pdnkabwj 211 5 be be VB cord-104204-pdnkabwj 211 6 drawn draw VBN cord-104204-pdnkabwj 211 7 from from IN cord-104204-pdnkabwj 211 8 this this DT cord-104204-pdnkabwj 211 9 study study NN cord-104204-pdnkabwj 211 10 whatever whatever WDT cord-104204-pdnkabwj 211 11 the the DT cord-104204-pdnkabwj 211 12 etiological etiological JJ cord-104204-pdnkabwj 211 13 factor factor NN cord-104204-pdnkabwj 211 14 is be VBZ cord-104204-pdnkabwj 211 15 , , , cord-104204-pdnkabwj 211 16 it -PRON- PRP cord-104204-pdnkabwj 211 17 will will MD cord-104204-pdnkabwj 211 18 induce induce VB cord-104204-pdnkabwj 211 19 BEN BEN NNP cord-104204-pdnkabwj 211 20 and/or and/or CC cord-104204-pdnkabwj 211 21 Volume Volume NNP cord-104204-pdnkabwj 211 22 106 106 CD cord-104204-pdnkabwj 211 23 , , , cord-104204-pdnkabwj 211 24 Number number NN cord-104204-pdnkabwj 211 25 I i NN cord-104204-pdnkabwj 211 26 1 1 CD cord-104204-pdnkabwj 211 27 , , , cord-104204-pdnkabwj 211 28 November November NNP cord-104204-pdnkabwj 211 29 1998 1998 CD cord-104204-pdnkabwj 212 1 * * NFP cord-104204-pdnkabwj 212 2 Environmental Environmental NNP cord-104204-pdnkabwj 212 3 Health Health NNP cord-104204-pdnkabwj 212 4 Perspectives Perspectives NNPS cord-104204-pdnkabwj 212 5 UTT UTT NNP cord-104204-pdnkabwj 212 6 only only RB cord-104204-pdnkabwj 212 7 after after IN cord-104204-pdnkabwj 212 8 metabolical metabolical JJ cord-104204-pdnkabwj 212 9 activation activation NN cord-104204-pdnkabwj 212 10 in in IN cord-104204-pdnkabwj 212 11 susceptible susceptible JJ cord-104204-pdnkabwj 212 12 individuals individual NNS cord-104204-pdnkabwj 212 13 ( ( -LRB- cord-104204-pdnkabwj 212 14 i.e. i.e. FW cord-104204-pdnkabwj 212 15 , , , cord-104204-pdnkabwj 212 16 extensive extensive JJ cord-104204-pdnkabwj 212 17 debrisoquine debrisoquine NN cord-104204-pdnkabwj 212 18 metabolizers metabolizer NNS cord-104204-pdnkabwj 212 19 ) ) -RRB- cord-104204-pdnkabwj 212 20 . . . cord-104204-pdnkabwj 213 1 Moreover moreover RB cord-104204-pdnkabwj 213 2 , , , cord-104204-pdnkabwj 213 3 the the DT cord-104204-pdnkabwj 213 4 development development NN cord-104204-pdnkabwj 213 5 of of IN cord-104204-pdnkabwj 213 6 UTTs utt NNS cord-104204-pdnkabwj 213 7 in in IN cord-104204-pdnkabwj 213 8 less less JJR cord-104204-pdnkabwj 213 9 than than IN cord-104204-pdnkabwj 213 10 half half NN cord-104204-pdnkabwj 213 11 of of IN cord-104204-pdnkabwj 213 12 the the DT cord-104204-pdnkabwj 213 13 BEN BEN NNP cord-104204-pdnkabwj 213 14 patients patient NNS cord-104204-pdnkabwj 213 15 may may MD cord-104204-pdnkabwj 213 16 reflect reflect VB cord-104204-pdnkabwj 213 17 differences difference NNS cord-104204-pdnkabwj 213 18 in in IN cord-104204-pdnkabwj 213 19 type type NN cord-104204-pdnkabwj 213 20 or or CC cord-104204-pdnkabwj 213 21 degree degree NN cord-104204-pdnkabwj 213 22 of of IN cord-104204-pdnkabwj 213 23 enzymatic enzymatic JJ cord-104204-pdnkabwj 213 24 efficiency efficiency NN cord-104204-pdnkabwj 213 25 in in IN cord-104204-pdnkabwj 213 26 these these DT cord-104204-pdnkabwj 213 27 subjects subject NNS cord-104204-pdnkabwj 213 28 ( ( -LRB- cord-104204-pdnkabwj 213 29 50 50 CD cord-104204-pdnkabwj 213 30 ) ) -RRB- cord-104204-pdnkabwj 213 31 . . . cord-104204-pdnkabwj 214 1 It -PRON- PRP cord-104204-pdnkabwj 214 2 is be VBZ cord-104204-pdnkabwj 214 3 not not RB cord-104204-pdnkabwj 214 4 known know VBN cord-104204-pdnkabwj 214 5 , , , cord-104204-pdnkabwj 214 6 however however RB cord-104204-pdnkabwj 214 7 , , , cord-104204-pdnkabwj 214 8 if if IN cord-104204-pdnkabwj 214 9 the the DT cord-104204-pdnkabwj 214 10 supposed suppose VBN cord-104204-pdnkabwj 214 11 BEN BEN NNP cord-104204-pdnkabwj 214 12 causing cause VBG cord-104204-pdnkabwj 214 13 toxicant(s toxicant(s NNP cord-104204-pdnkabwj 214 14 ) ) -RRB- cord-104204-pdnkabwj 214 15 is be VBZ cord-104204-pdnkabwj 214 16 activated activate VBN cord-104204-pdnkabwj 214 17 specifically specifically RB cord-104204-pdnkabwj 214 18 in in IN cord-104204-pdnkabwj 214 19 the the DT cord-104204-pdnkabwj 214 20 kidney kidney NN cord-104204-pdnkabwj 214 21 , , , cord-104204-pdnkabwj 214 22 or or CC cord-104204-pdnkabwj 214 23 if if IN cord-104204-pdnkabwj 214 24 it -PRON- PRP cord-104204-pdnkabwj 214 25 is be VBZ cord-104204-pdnkabwj 214 26 first first RB cord-104204-pdnkabwj 214 27 metabolized metabolized JJ cord-104204-pdnkabwj 214 28 to to IN cord-104204-pdnkabwj 214 29 the the DT cord-104204-pdnkabwj 214 30 active active JJ cord-104204-pdnkabwj 214 31 form form NN cord-104204-pdnkabwj 214 32 in in IN cord-104204-pdnkabwj 214 33 the the DT cord-104204-pdnkabwj 214 34 liver liver NN cord-104204-pdnkabwj 214 35 and and CC cord-104204-pdnkabwj 214 36 subsequently subsequently RB cord-104204-pdnkabwj 214 37 transported transport VBD cord-104204-pdnkabwj 214 38 to to IN cord-104204-pdnkabwj 214 39 the the DT cord-104204-pdnkabwj 214 40 kidney kidney NN cord-104204-pdnkabwj 214 41 where where WRB cord-104204-pdnkabwj 214 42 it -PRON- PRP cord-104204-pdnkabwj 214 43 induces induce VBZ cord-104204-pdnkabwj 214 44 the the DT cord-104204-pdnkabwj 214 45 progressive progressive JJ cord-104204-pdnkabwj 214 46 tissue tissue NN cord-104204-pdnkabwj 214 47 damage damage NN cord-104204-pdnkabwj 214 48 . . . cord-104204-pdnkabwj 215 1 On on IN cord-104204-pdnkabwj 215 2 the the DT cord-104204-pdnkabwj 215 3 other other JJ cord-104204-pdnkabwj 215 4 hand hand NN cord-104204-pdnkabwj 215 5 , , , cord-104204-pdnkabwj 215 6 experiments experiment NNS cord-104204-pdnkabwj 215 7 in in IN cord-104204-pdnkabwj 215 8 animals animal NNS cord-104204-pdnkabwj 215 9 showed show VBD cord-104204-pdnkabwj 215 10 that that IN cord-104204-pdnkabwj 215 11 the the DT cord-104204-pdnkabwj 215 12 nephrotoxicity nephrotoxicity NN cord-104204-pdnkabwj 215 13 and and CC cord-104204-pdnkabwj 215 14 carcinogenicity carcinogenicity NN cord-104204-pdnkabwj 215 15 of of IN cord-104204-pdnkabwj 215 16 OTA OTA NNP cord-104204-pdnkabwj 215 17 is be VBZ cord-104204-pdnkabwj 215 18 not not RB cord-104204-pdnkabwj 215 19 altered alter VBN cord-104204-pdnkabwj 215 20 significantly significantly RB cord-104204-pdnkabwj 215 21 by by IN cord-104204-pdnkabwj 215 22 metabolism metabolism NN cord-104204-pdnkabwj 215 23 . . . cord-104204-pdnkabwj 216 1 One one CD cord-104204-pdnkabwj 216 2 of of IN cord-104204-pdnkabwj 216 3 the the DT cord-104204-pdnkabwj 216 4 major major JJ cord-104204-pdnkabwj 216 5 metabolites metabolite NNS cord-104204-pdnkabwj 216 6 that that WDT cord-104204-pdnkabwj 216 7 preserves preserve VBZ cord-104204-pdnkabwj 216 8 almost almost RB cord-104204-pdnkabwj 216 9 the the DT cord-104204-pdnkabwj 216 10 full full JJ cord-104204-pdnkabwj 216 11 toxicity toxicity NN cord-104204-pdnkabwj 216 12 of of IN cord-104204-pdnkabwj 216 13 OTA OTA NNP cord-104204-pdnkabwj 216 14 is be VBZ cord-104204-pdnkabwj 216 15 4(R)-hydroxyochratoxin 4(r)-hydroxyochratoxin CD cord-104204-pdnkabwj 216 16 A A NNP cord-104204-pdnkabwj 216 17 , , , cord-104204-pdnkabwj 216 18 generated generate VBN cord-104204-pdnkabwj 216 19 by by IN cord-104204-pdnkabwj 216 20 the the DT cord-104204-pdnkabwj 216 21 mixed mixed JJ cord-104204-pdnkabwj 216 22 function function NN cord-104204-pdnkabwj 216 23 oxidase oxidase NN cord-104204-pdnkabwj 216 24 system system NN cord-104204-pdnkabwj 216 25 ( ( -LRB- cord-104204-pdnkabwj 216 26 51 51 CD cord-104204-pdnkabwj 216 27 ) ) -RRB- cord-104204-pdnkabwj 216 28 . . . cord-104204-pdnkabwj 217 1 This this DT cord-104204-pdnkabwj 217 2 suggests suggest VBZ cord-104204-pdnkabwj 217 3 , , , cord-104204-pdnkabwj 217 4 once once RB cord-104204-pdnkabwj 217 5 again again RB cord-104204-pdnkabwj 217 6 , , , cord-104204-pdnkabwj 217 7 that that IN cord-104204-pdnkabwj 217 8 it -PRON- PRP cord-104204-pdnkabwj 217 9 is be VBZ cord-104204-pdnkabwj 217 10 unlikely unlikely JJ cord-104204-pdnkabwj 217 11 that that IN cord-104204-pdnkabwj 217 12 OTA OTA NNP cord-104204-pdnkabwj 217 13 is be VBZ cord-104204-pdnkabwj 217 14 the the DT cord-104204-pdnkabwj 217 15 ( ( -LRB- cord-104204-pdnkabwj 217 16 sole sole JJ cord-104204-pdnkabwj 217 17 ) ) -RRB- cord-104204-pdnkabwj 217 18 causative causative JJ cord-104204-pdnkabwj 217 19 factor factor NN cord-104204-pdnkabwj 217 20 for for IN cord-104204-pdnkabwj 217 21 BEN BEN NNP cord-104204-pdnkabwj 217 22 and and CC cord-104204-pdnkabwj 217 23 UTT UTT NNP cord-104204-pdnkabwj 217 24 . . . cord-104204-pdnkabwj 218 1 Ochratoxin Ochratoxin NNP cord-104204-pdnkabwj 218 2 A A NNP cord-104204-pdnkabwj 218 3 also also RB cord-104204-pdnkabwj 218 4 seems seem VBZ cord-104204-pdnkabwj 218 5 to to TO cord-104204-pdnkabwj 218 6 be be VB cord-104204-pdnkabwj 218 7 metabolized metabolize VBN cord-104204-pdnkabwj 218 8 by by IN cord-104204-pdnkabwj 218 9 a a DT cord-104204-pdnkabwj 218 10 different different JJ cord-104204-pdnkabwj 218 11 hydroxylase hydroxylase NN cord-104204-pdnkabwj 218 12 than than IN cord-104204-pdnkabwj 218 13 for for IN cord-104204-pdnkabwj 218 14 debrisoquine debrisoquine NN cord-104204-pdnkabwj 218 15 , , , cord-104204-pdnkabwj 218 16 as as IN cord-104204-pdnkabwj 218 17 only only RB cord-104204-pdnkabwj 218 18 the the DT cord-104204-pdnkabwj 218 19 former former JJ cord-104204-pdnkabwj 218 20 is be VBZ cord-104204-pdnkabwj 218 21 inducible inducible JJ cord-104204-pdnkabwj 218 22 by by IN cord-104204-pdnkabwj 218 23 methylcholanthrene methylcholanthrene JJ cord-104204-pdnkabwj 218 24 or or CC cord-104204-pdnkabwj 218 25 phenobarbital phenobarbital NN cord-104204-pdnkabwj 218 26 ( ( -LRB- cord-104204-pdnkabwj 218 27 51 51 CD cord-104204-pdnkabwj 218 28 ) ) -RRB- cord-104204-pdnkabwj 218 29 . . . cord-104204-pdnkabwj 219 1 Nevertheless nevertheless RB cord-104204-pdnkabwj 219 2 , , , cord-104204-pdnkabwj 219 3 in in IN cord-104204-pdnkabwj 219 4 this this DT cord-104204-pdnkabwj 219 5 case case NN cord-104204-pdnkabwj 219 6 , , , cord-104204-pdnkabwj 219 7 interspecies interspecies NN cord-104204-pdnkabwj 219 8 metabolization metabolization NN cord-104204-pdnkabwj 219 9 and and CC cord-104204-pdnkabwj 219 10 enzymatic enzymatic JJ cord-104204-pdnkabwj 219 11 differences difference NNS cord-104204-pdnkabwj 219 12 make make VBP cord-104204-pdnkabwj 219 13 extrapolation extrapolation NN cord-104204-pdnkabwj 219 14 from from IN cord-104204-pdnkabwj 219 15 laboratory laboratory NN cord-104204-pdnkabwj 219 16 animals animal NNS cord-104204-pdnkabwj 219 17 to to IN cord-104204-pdnkabwj 219 18 humans human NNS cord-104204-pdnkabwj 219 19 difficult difficult JJ cord-104204-pdnkabwj 219 20 . . . cord-104204-pdnkabwj 220 1 It -PRON- PRP cord-104204-pdnkabwj 220 2 can can MD cord-104204-pdnkabwj 220 3 not not RB cord-104204-pdnkabwj 220 4 be be VB cord-104204-pdnkabwj 220 5 ruled rule VBN cord-104204-pdnkabwj 220 6 out out RP cord-104204-pdnkabwj 220 7 that that IN cord-104204-pdnkabwj 220 8 the the DT cord-104204-pdnkabwj 220 9 suspected suspect VBN cord-104204-pdnkabwj 220 10 aromatic aromatic JJ cord-104204-pdnkabwj 220 11 compounds compound NNS cord-104204-pdnkabwj 220 12 from from IN cord-104204-pdnkabwj 220 13 the the DT cord-104204-pdnkabwj 220 14 endemic endemic JJ cord-104204-pdnkabwj 220 15 drinking drinking NN cord-104204-pdnkabwj 220 16 water water NN cord-104204-pdnkabwj 220 17 , , , cord-104204-pdnkabwj 220 18 besides besides IN cord-104204-pdnkabwj 220 19 being be VBG cord-104204-pdnkabwj 220 20 nephrotoxic nephrotoxic NNP cord-104204-pdnkabwj 220 21 , , , cord-104204-pdnkabwj 220 22 contribute contribute VB cord-104204-pdnkabwj 220 23 additionally additionally RB cord-104204-pdnkabwj 220 24 to to IN cord-104204-pdnkabwj 220 25 the the DT cord-104204-pdnkabwj 220 26 disease disease NN cord-104204-pdnkabwj 220 27 etiopathogenicity etiopathogenicity NN cord-104204-pdnkabwj 220 28 by by IN cord-104204-pdnkabwj 220 29 inducing induce VBG cord-104204-pdnkabwj 220 30 enzymes enzyme NNS cord-104204-pdnkabwj 220 31 that that WDT cord-104204-pdnkabwj 220 32 alter alter VBP cord-104204-pdnkabwj 220 33 OTA OTA NNP cord-104204-pdnkabwj 220 34 and and CC cord-104204-pdnkabwj 220 35 extend extend VB cord-104204-pdnkabwj 220 36 in in IN cord-104204-pdnkabwj 220 37 this this DT cord-104204-pdnkabwj 220 38 way way NN cord-104204-pdnkabwj 220 39 its -PRON- PRP$ cord-104204-pdnkabwj 220 40 pattern pattern NN cord-104204-pdnkabwj 220 41 of of IN cord-104204-pdnkabwj 220 42 toxicity toxicity NN cord-104204-pdnkabwj 220 43 . . . cord-104204-pdnkabwj 221 1 The the DT cord-104204-pdnkabwj 221 2 higher high JJR cord-104204-pdnkabwj 221 3 incidence incidence NN cord-104204-pdnkabwj 221 4 of of IN cord-104204-pdnkabwj 221 5 UITs uit NNS cord-104204-pdnkabwj 221 6 , , , cord-104204-pdnkabwj 221 7 with with IN cord-104204-pdnkabwj 221 8 no no DT cord-104204-pdnkabwj 221 9 increase increase NN cord-104204-pdnkabwj 221 10 in in IN cord-104204-pdnkabwj 221 11 the the DT cord-104204-pdnkabwj 221 12 incidence incidence NN cord-104204-pdnkabwj 221 13 of of IN cord-104204-pdnkabwj 221 14 bladder bladder NN cord-104204-pdnkabwj 221 15 cancer cancer NN cord-104204-pdnkabwj 221 16 , , , cord-104204-pdnkabwj 221 17 in in IN cord-104204-pdnkabwj 221 18 non non JJ cord-104204-pdnkabwj 221 19 - - JJ cord-104204-pdnkabwj 221 20 BEN BEN NNP cord-104204-pdnkabwj 221 21 interstitial interstitial JJ cord-104204-pdnkabwj 221 22 nephropathies nephropathy NNS cord-104204-pdnkabwj 221 23 ( ( -LRB- cord-104204-pdnkabwj 221 24 e.g. e.g. RB cord-104204-pdnkabwj 221 25 , , , cord-104204-pdnkabwj 221 26 analgesic analgesic JJ cord-104204-pdnkabwj 221 27 nephropathy nephropathy NN cord-104204-pdnkabwj 221 28 , , , cord-104204-pdnkabwj 221 29 interstitial interstitial JJ cord-104204-pdnkabwj 221 30 nephropathy nephropathy NN cord-104204-pdnkabwj 221 31 induced induce VBN cord-104204-pdnkabwj 221 32 by by IN cord-104204-pdnkabwj 221 33 renal renal JJ cord-104204-pdnkabwj 221 34 lithiasis lithiasis NN cord-104204-pdnkabwj 221 35 ) ) -RRB- cord-104204-pdnkabwj 221 36 contradicted contradict VBD cord-104204-pdnkabwj 221 37 the the DT cord-104204-pdnkabwj 221 38 carcinogenicity carcinogenicity NN cord-104204-pdnkabwj 221 39 of of IN cord-104204-pdnkabwj 221 40 BEN BEN NNP cord-104204-pdnkabwj 221 41 agent(s agent(s NNP cord-104204-pdnkabwj 221 42 ) ) -RRB- cord-104204-pdnkabwj 221 43 , , , cord-104204-pdnkabwj 221 44 suggesting suggest VBG cord-104204-pdnkabwj 221 45 in in IN cord-104204-pdnkabwj 221 46 the the DT cord-104204-pdnkabwj 221 47 extreme extreme JJ cord-104204-pdnkabwj 221 48 case case NN cord-104204-pdnkabwj 221 49 that that WDT cord-104204-pdnkabwj 221 50 BEN BEN NNP cord-104204-pdnkabwj 221 51 causing cause VBG cord-104204-pdnkabwj 221 52 factor(s factor(s NNP cord-104204-pdnkabwj 221 53 ) ) -RRB- cord-104204-pdnkabwj 221 54 has have VBZ cord-104204-pdnkabwj 221 55 no no DT cord-104204-pdnkabwj 221 56 direct direct JJ cord-104204-pdnkabwj 221 57 carcinogenic carcinogenic JJ cord-104204-pdnkabwj 221 58 activity activity NN cord-104204-pdnkabwj 221 59 at at RB cord-104204-pdnkabwj 221 60 all all DT cord-104204-pdnkabwj 221 61 ( ( -LRB- cord-104204-pdnkabwj 221 62 52 52 CD cord-104204-pdnkabwj 221 63 . . . cord-104204-pdnkabwj 222 1 The the DT cord-104204-pdnkabwj 222 2 occurrence occurrence NN cord-104204-pdnkabwj 222 3 of of IN cord-104204-pdnkabwj 222 4 UTTs utt NNS cord-104204-pdnkabwj 222 5 only only RB cord-104204-pdnkabwj 222 6 in in IN cord-104204-pdnkabwj 222 7 the the DT cord-104204-pdnkabwj 222 8 advanced advanced JJ cord-104204-pdnkabwj 222 9 stages stage NNS cord-104204-pdnkabwj 222 10 of of IN cord-104204-pdnkabwj 222 11 BEN BEN NNP cord-104204-pdnkabwj 222 12 ( ( -LRB- cord-104204-pdnkabwj 222 13 frequently frequently RB cord-104204-pdnkabwj 222 14 after after IN cord-104204-pdnkabwj 222 15 renal renal JJ cord-104204-pdnkabwj 222 16 failure failure NN cord-104204-pdnkabwj 222 17 is be VBZ cord-104204-pdnkabwj 222 18 diagnosed diagnose VBN cord-104204-pdnkabwj 222 19 and and CC cord-104204-pdnkabwj 222 20 renal renal JJ cord-104204-pdnkabwj 222 21 dialysis dialysis NN cord-104204-pdnkabwj 222 22 is be VBZ cord-104204-pdnkabwj 222 23 performed perform VBN cord-104204-pdnkabwj 222 24 ) ) -RRB- cord-104204-pdnkabwj 222 25 , , , cord-104204-pdnkabwj 222 26 however however RB cord-104204-pdnkabwj 222 27 , , , cord-104204-pdnkabwj 222 28 could could MD cord-104204-pdnkabwj 222 29 be be VB cord-104204-pdnkabwj 222 30 the the DT cord-104204-pdnkabwj 222 31 result result NN cord-104204-pdnkabwj 222 32 of of IN cord-104204-pdnkabwj 222 33 a a DT cord-104204-pdnkabwj 222 34 weak weak JJ cord-104204-pdnkabwj 222 35 oncogenic oncogenic JJ cord-104204-pdnkabwj 222 36 agent agent NN cord-104204-pdnkabwj 222 37 . . . cord-104204-pdnkabwj 223 1 While while IN cord-104204-pdnkabwj 223 2 no no DT cord-104204-pdnkabwj 223 3 tumorigenic tumorigenic JJ cord-104204-pdnkabwj 223 4 effect effect NN cord-104204-pdnkabwj 223 5 is be VBZ cord-104204-pdnkabwj 223 6 observed observe VBN cord-104204-pdnkabwj 223 7 in in IN cord-104204-pdnkabwj 223 8 the the DT cord-104204-pdnkabwj 223 9 earlier early JJR cord-104204-pdnkabwj 223 10 phases phase NNS cord-104204-pdnkabwj 223 11 of of IN cord-104204-pdnkabwj 223 12 BEN BEN NNP cord-104204-pdnkabwj 223 13 , , , cord-104204-pdnkabwj 223 14 when when WRB cord-104204-pdnkabwj 223 15 kidney kidney NN cord-104204-pdnkabwj 223 16 morphology morphology NN cord-104204-pdnkabwj 223 17 is be VBZ cord-104204-pdnkabwj 223 18 still still RB cord-104204-pdnkabwj 223 19 preserved preserve VBN cord-104204-pdnkabwj 223 20 , , , cord-104204-pdnkabwj 223 21 the the DT cord-104204-pdnkabwj 223 22 alteration alteration NN cord-104204-pdnkabwj 223 23 of of IN cord-104204-pdnkabwj 223 24 the the DT cord-104204-pdnkabwj 223 25 pyelo pyelo NNP cord-104204-pdnkabwj 223 26 - - HYPH cord-104204-pdnkabwj 223 27 and and CC cord-104204-pdnkabwj 223 28 ureterolymphatic ureterolymphatic JJ cord-104204-pdnkabwj 223 29 drainage drainage NN cord-104204-pdnkabwj 223 30 system system NN cord-104204-pdnkabwj 223 31 following follow VBG cord-104204-pdnkabwj 223 32 the the DT cord-104204-pdnkabwj 223 33 kidney kidney NN cord-104204-pdnkabwj 223 34 destruction destruction NN cord-104204-pdnkabwj 223 35 leads lead VBZ cord-104204-pdnkabwj 223 36 to to IN cord-104204-pdnkabwj 223 37 stasis stasis NN cord-104204-pdnkabwj 223 38 and and CC cord-104204-pdnkabwj 223 39 accumulation accumulation NN cord-104204-pdnkabwj 223 40 of of IN cord-104204-pdnkabwj 223 41 the the DT cord-104204-pdnkabwj 223 42 nephrotoxic nephrotoxic NNP cord-104204-pdnkabwj 223 43 factor(s factor(s NNP cord-104204-pdnkabwj 223 44 ) ) -RRB- cord-104204-pdnkabwj 223 45 in in IN cord-104204-pdnkabwj 223 46 the the DT cord-104204-pdnkabwj 223 47 urothelium urothelium NN cord-104204-pdnkabwj 223 48 , , , cord-104204-pdnkabwj 223 49 and and CC cord-104204-pdnkabwj 223 50 a a DT cord-104204-pdnkabwj 223 51 ( ( -LRB- cord-104204-pdnkabwj 223 52 pro)carcinogenic pro)carcinogenic JJ cord-104204-pdnkabwj 223 53 threshold threshold NN cord-104204-pdnkabwj 223 54 is be VBZ cord-104204-pdnkabwj 223 55 reached reach VBN cord-104204-pdnkabwj 223 56 with with IN cord-104204-pdnkabwj 223 57 subsequent subsequent JJ cord-104204-pdnkabwj 223 58 induction induction NN cord-104204-pdnkabwj 223 59 / / SYM cord-104204-pdnkabwj 223 60 promotion promotion NN cord-104204-pdnkabwj 223 61 oftumorigenesis oftumorigenesis NN cord-104204-pdnkabwj 223 62 . . . cord-104204-pdnkabwj 224 1 The the DT cord-104204-pdnkabwj 224 2 etiology etiology NN cord-104204-pdnkabwj 224 3 of of IN cord-104204-pdnkabwj 224 4 BEN BEN NNP cord-104204-pdnkabwj 224 5 - - HYPH cord-104204-pdnkabwj 224 6 linked link VBN cord-104204-pdnkabwj 224 7 urinary urinary JJ cord-104204-pdnkabwj 224 8 tumors tumor NNS cord-104204-pdnkabwj 224 9 is be VBZ cord-104204-pdnkabwj 224 10 still still RB cord-104204-pdnkabwj 224 11 speculative speculative JJ cord-104204-pdnkabwj 224 12 , , , cord-104204-pdnkabwj 224 13 as as IN cord-104204-pdnkabwj 224 14 is be VBZ cord-104204-pdnkabwj 224 15 the the DT cord-104204-pdnkabwj 224 16 cause cause NN cord-104204-pdnkabwj 224 17 of of IN cord-104204-pdnkabwj 224 18 the the DT cord-104204-pdnkabwj 224 19 background background NN cord-104204-pdnkabwj 224 20 disease disease NN cord-104204-pdnkabwj 224 21 . . . cord-104204-pdnkabwj 225 1 However however RB cord-104204-pdnkabwj 225 2 , , , cord-104204-pdnkabwj 225 3 no no DT cord-104204-pdnkabwj 225 4 other other JJ cord-104204-pdnkabwj 225 5 known know VBN cord-104204-pdnkabwj 225 6 human human JJ cord-104204-pdnkabwj 225 7 disease disease NN cord-104204-pdnkabwj 225 8 , , , cord-104204-pdnkabwj 225 9 with with IN cord-104204-pdnkabwj 225 10 the the DT cord-104204-pdnkabwj 225 11 possible possible JJ cord-104204-pdnkabwj 225 12 exception exception NN cord-104204-pdnkabwj 225 13 of of IN cord-104204-pdnkabwj 225 14 analgesic analgesic JJ cord-104204-pdnkabwj 225 15 nephropathy nephropathy NN cord-104204-pdnkabwj 225 16 , , , cord-104204-pdnkabwj 225 17 is be VBZ cord-104204-pdnkabwj 225 18 so so RB cord-104204-pdnkabwj 225 19 frequently frequently RB cord-104204-pdnkabwj 225 20 associated associate VBN cord-104204-pdnkabwj 225 21 with with IN cord-104204-pdnkabwj 225 22 ureteral ureteral JJ cord-104204-pdnkabwj 225 23 and and CC cord-104204-pdnkabwj 225 24 renal renal JJ cord-104204-pdnkabwj 225 25 pelvis pelvi NNS cord-104204-pdnkabwj 225 26 carcinomas carcinoma NNS cord-104204-pdnkabwj 225 27 . . . cord-104204-pdnkabwj 226 1 The the DT cord-104204-pdnkabwj 226 2 molecular molecular JJ cord-104204-pdnkabwj 226 3 description description NN cord-104204-pdnkabwj 226 4 of of IN cord-104204-pdnkabwj 226 5 BEN BEN NNP cord-104204-pdnkabwj 226 6 - - HYPH cord-104204-pdnkabwj 226 7 linked link VBN cord-104204-pdnkabwj 226 8 tumorigenesis tumorigenesis NN cord-104204-pdnkabwj 226 9 and and CC cord-104204-pdnkabwj 226 10 the the DT cord-104204-pdnkabwj 226 11 influence influence NN cord-104204-pdnkabwj 226 12 of of IN cord-104204-pdnkabwj 226 13 a a DT cord-104204-pdnkabwj 226 14 familial familial JJ cord-104204-pdnkabwj 226 15 or or CC cord-104204-pdnkabwj 226 16 individual individual JJ cord-104204-pdnkabwj 226 17 susceptibility susceptibility NN cord-104204-pdnkabwj 226 18 to to IN cord-104204-pdnkabwj 226 19 UTT UTT NNP cord-104204-pdnkabwj 226 20 could could MD cord-104204-pdnkabwj 226 21 offer offer VB cord-104204-pdnkabwj 226 22 an an DT cord-104204-pdnkabwj 226 23 important important JJ cord-104204-pdnkabwj 226 24 arena arena NN cord-104204-pdnkabwj 226 25 of of IN cord-104204-pdnkabwj 226 26 research research NN cord-104204-pdnkabwj 226 27 for for IN cord-104204-pdnkabwj 226 28 molecular molecular JJ cord-104204-pdnkabwj 226 29 and and CC cord-104204-pdnkabwj 226 30 environmentally environmentally RB cord-104204-pdnkabwj 226 31 induced induce VBN cord-104204-pdnkabwj 226 32 carcinogenesis carcinogenesis NN cord-104204-pdnkabwj 226 33 . . . cord-104204-pdnkabwj 227 1 Aristolochic Aristolochic NNP cord-104204-pdnkabwj 227 2 Acid Acid NNP cord-104204-pdnkabwj 228 1 An an DT cord-104204-pdnkabwj 228 2 interesting interesting JJ cord-104204-pdnkabwj 228 3 association association NN cord-104204-pdnkabwj 228 4 has have VBZ cord-104204-pdnkabwj 228 5 been be VBN cord-104204-pdnkabwj 228 6 made make VBN cord-104204-pdnkabwj 228 7 between between IN cord-104204-pdnkabwj 228 8 Chinese chinese JJ cord-104204-pdnkabwj 228 9 herb herb NN cord-104204-pdnkabwj 228 10 nephropathy nephropathy NN cord-104204-pdnkabwj 228 11 ( ( -LRB- cord-104204-pdnkabwj 228 12 CHN CHN NNP cord-104204-pdnkabwj 228 13 ) ) -RRB- cord-104204-pdnkabwj 228 14 and and CC cord-104204-pdnkabwj 228 15 BEN BEN NNP cord-104204-pdnkabwj 228 16 ( ( -LRB- cord-104204-pdnkabwj 228 17 53 53 CD cord-104204-pdnkabwj 228 18 ) ) -RRB- cord-104204-pdnkabwj 228 19 . . . cord-104204-pdnkabwj 229 1 The the DT cord-104204-pdnkabwj 229 2 incriminated incriminate VBN cord-104204-pdnkabwj 229 3 agent agent NN cord-104204-pdnkabwj 229 4 in in IN cord-104204-pdnkabwj 229 5 this this DT cord-104204-pdnkabwj 229 6 case case NN cord-104204-pdnkabwj 229 7 is be VBZ cord-104204-pdnkabwj 229 8 aristolochic aristolochic JJ cord-104204-pdnkabwj 229 9 acid acid NN cord-104204-pdnkabwj 229 10 , , , cord-104204-pdnkabwj 229 11 a a DT cord-104204-pdnkabwj 229 12 known know VBN cord-104204-pdnkabwj 229 13 nephrotoxic nephrotoxic JJ cord-104204-pdnkabwj 229 14 and and CC cord-104204-pdnkabwj 229 15 carcinogenic carcinogenic JJ cord-104204-pdnkabwj 229 16 compound compound NN cord-104204-pdnkabwj 229 17 synthesized synthesize VBN cord-104204-pdnkabwj 229 18 in in IN cord-104204-pdnkabwj 229 19 various various JJ cord-104204-pdnkabwj 229 20 portions portion NNS cord-104204-pdnkabwj 229 21 ofAristolochia ofAristolochia NNP cord-104204-pdnkabwj 229 22 plants plant NNS cord-104204-pdnkabwj 229 23 . . . cord-104204-pdnkabwj 230 1 The the DT cord-104204-pdnkabwj 230 2 nephropathy nephropathy NN cord-104204-pdnkabwj 230 3 was be VBD cord-104204-pdnkabwj 230 4 described describe VBN cord-104204-pdnkabwj 230 5 in in IN cord-104204-pdnkabwj 230 6 several several JJ cord-104204-pdnkabwj 230 7 hundred hundred CD cord-104204-pdnkabwj 230 8 young young JJ cord-104204-pdnkabwj 230 9 women woman NNS cord-104204-pdnkabwj 230 10 in in IN cord-104204-pdnkabwj 230 11 Belgium Belgium NNP cord-104204-pdnkabwj 230 12 and and CC cord-104204-pdnkabwj 230 13 , , , cord-104204-pdnkabwj 230 14 more more RBR cord-104204-pdnkabwj 230 15 recently recently RB cord-104204-pdnkabwj 230 16 , , , cord-104204-pdnkabwj 230 17 in in IN cord-104204-pdnkabwj 230 18 Japan Japan NNP cord-104204-pdnkabwj 230 19 ( ( -LRB- cord-104204-pdnkabwj 230 20 54 54 CD cord-104204-pdnkabwj 230 21 ) ) -RRB- cord-104204-pdnkabwj 230 22 who who WP cord-104204-pdnkabwj 230 23 followed follow VBD cord-104204-pdnkabwj 230 24 a a DT cord-104204-pdnkabwj 230 25 slimming slimming JJ cord-104204-pdnkabwj 230 26 diet diet NN cord-104204-pdnkabwj 230 27 ( ( -LRB- cord-104204-pdnkabwj 230 28 accidentally accidentally RB cord-104204-pdnkabwj 230 29 containing contain VBG cord-104204-pdnkabwj 230 30 plant plant NN cord-104204-pdnkabwj 230 31 parts part NNS cord-104204-pdnkabwj 230 32 of of IN cord-104204-pdnkabwj 230 33 Aristolochia Aristolochia NNP cord-104204-pdnkabwj 230 34 , , , cord-104204-pdnkabwj 230 35 instead instead RB cord-104204-pdnkabwj 230 36 of of IN cord-104204-pdnkabwj 230 37 Stephania Stephania NNP cord-104204-pdnkabwj 230 38 tetrandra tetrandra NNP cord-104204-pdnkabwj 230 39 ) ) -RRB- cord-104204-pdnkabwj 230 40 for for IN cord-104204-pdnkabwj 230 41 several several JJ cord-104204-pdnkabwj 230 42 years year NNS cord-104204-pdnkabwj 230 43 and and CC cord-104204-pdnkabwj 230 44 a a DT cord-104204-pdnkabwj 230 45 cure cure NN cord-104204-pdnkabwj 230 46 for for IN cord-104204-pdnkabwj 230 47 atopic atopic JJ cord-104204-pdnkabwj 230 48 dermatitis dermatitis NN cord-104204-pdnkabwj 230 49 , , , cord-104204-pdnkabwj 230 50 respectively respectively RB cord-104204-pdnkabwj 230 51 . . . cord-104204-pdnkabwj 231 1 CHN CHN NNP cord-104204-pdnkabwj 231 2 resembles resemble VBZ cord-104204-pdnkabwj 231 3 BEN BEN NNP cord-104204-pdnkabwj 231 4 in in IN cord-104204-pdnkabwj 231 5 many many JJ cord-104204-pdnkabwj 231 6 aspects aspect NNS cord-104204-pdnkabwj 231 7 : : : cord-104204-pdnkabwj 231 8 dinical dinical JJ cord-104204-pdnkabwj 231 9 - - HYPH cord-104204-pdnkabwj 231 10 normal normal JJ cord-104204-pdnkabwj 231 11 blood blood NN cord-104204-pdnkabwj 231 12 pressure pressure NN cord-104204-pdnkabwj 231 13 ; ; : cord-104204-pdnkabwj 231 14 aseptic aseptic JJ cord-104204-pdnkabwj 231 15 leukocyturia leukocyturia NN cord-104204-pdnkabwj 231 16 ; ; : cord-104204-pdnkabwj 231 17 low low JJ cord-104204-pdnkabwj 231 18 grade grade NN cord-104204-pdnkabwj 231 19 , , , cord-104204-pdnkabwj 231 20 low low JJ cord-104204-pdnkabwj 231 21 molecular molecular JJ cord-104204-pdnkabwj 231 22 weight weight NN cord-104204-pdnkabwj 231 23 proteinuria proteinuria NN cord-104204-pdnkabwj 231 24 ; ; : cord-104204-pdnkabwj 231 25 early early JJ cord-104204-pdnkabwj 231 26 and and CC cord-104204-pdnkabwj 231 27 severe severe JJ cord-104204-pdnkabwj 231 28 anemia anemia NN cord-104204-pdnkabwj 231 29 and and CC cord-104204-pdnkabwj 231 30 morphopathological morphopathological JJ cord-104204-pdnkabwj 231 31 - - HYPH cord-104204-pdnkabwj 231 32 extensive extensive JJ cord-104204-pdnkabwj 231 33 hypocellular hypocellular NNP cord-104204-pdnkabwj 231 34 interstitial interstitial JJ cord-104204-pdnkabwj 231 35 sderosis sderosis NNP cord-104204-pdnkabwj 231 36 ; ; : cord-104204-pdnkabwj 231 37 tubular tubular JJ cord-104204-pdnkabwj 231 38 atrophy atrophy NN cord-104204-pdnkabwj 231 39 and and CC cord-104204-pdnkabwj 231 40 global global JJ cord-104204-pdnkabwj 231 41 sderosis sderosis NN cord-104204-pdnkabwj 231 42 of of IN cord-104204-pdnkabwj 231 43 Table Table NNP cord-104204-pdnkabwj 231 44 2 2 CD cord-104204-pdnkabwj 231 45 . . . cord-104204-pdnkabwj 232 1 Summary summary NN cord-104204-pdnkabwj 232 2 of of IN cord-104204-pdnkabwj 232 3 the the DT cord-104204-pdnkabwj 232 4 main main JJ cord-104204-pdnkabwj 232 5 findings finding NNS cord-104204-pdnkabwj 232 6 that that WDT cord-104204-pdnkabwj 232 7 support support VBP cord-104204-pdnkabwj 232 8 the the DT cord-104204-pdnkabwj 232 9 role role NN cord-104204-pdnkabwj 232 10 of of IN cord-104204-pdnkabwj 232 11 the the DT cord-104204-pdnkabwj 232 12 low low JJ cord-104204-pdnkabwj 232 13 - - HYPH cord-104204-pdnkabwj 232 14 rank rank NN cord-104204-pdnkabwj 232 15 coals coal NNS cord-104204-pdnkabwj 232 16 ( ( -LRB- cord-104204-pdnkabwj 232 17 Pliocene Pliocene NNP cord-104204-pdnkabwj 232 18 lignites lignite NNS cord-104204-pdnkabwj 232 19 ) ) -RRB- cord-104204-pdnkabwj 232 20 and and CC cord-104204-pdnkabwj 232 21 the the DT cord-104204-pdnkabwj 232 22 hydrogeological hydrogeological JJ cord-104204-pdnkabwj 232 23 factor factor NN cord-104204-pdnkabwj 232 24 in in IN cord-104204-pdnkabwj 232 25 Balkan balkan JJ cord-104204-pdnkabwj 232 26 endemic endemic JJ cord-104204-pdnkabwj 232 27 nephropathy nephropathy NN cord-104204-pdnkabwj 232 28 / / SYM cord-104204-pdnkabwj 232 29 upper upper JJ cord-104204-pdnkabwj 232 30 urinary urinary JJ cord-104204-pdnkabwj 232 31 tract tract NN cord-104204-pdnkabwj 232 32 tumor tumor NN cord-104204-pdnkabwj 232 33 ( ( -LRB- cord-104204-pdnkabwj 232 34 BEN BEN NNP cord-104204-pdnkabwj 232 35 / / SYM cord-104204-pdnkabwj 232 36 UTT UTT NNP cord-104204-pdnkabwj 232 37 ) ) -RRB- cord-104204-pdnkabwj 232 38 etiology etiology NN cord-104204-pdnkabwj 232 39 , , , cord-104204-pdnkabwj 232 40 and and CC cord-104204-pdnkabwj 232 41 disagree disagree VB cord-104204-pdnkabwj 232 42 with with IN cord-104204-pdnkabwj 232 43 the the DT cord-104204-pdnkabwj 232 44 hypothesis hypothesis NN cord-104204-pdnkabwj 232 45 and and CC cord-104204-pdnkabwj 232 46 the the DT cord-104204-pdnkabwj 232 47 additional additional JJ cord-104204-pdnkabwj 232 48 research research NN cord-104204-pdnkabwj 232 49 needed need VBN cord-104204-pdnkabwj 232 50 to to TO cord-104204-pdnkabwj 232 51 confirm confirm VB cord-104204-pdnkabwj 232 52 the the DT cord-104204-pdnkabwj 232 53 hypothesis hypothesis NN cord-104204-pdnkabwj 232 54 PROs pro NNS cord-104204-pdnkabwj 232 55 Earlier early JJR cord-104204-pdnkabwj 232 56 research research NN cord-104204-pdnkabwj 232 57 ( ( -LRB- cord-104204-pdnkabwj 232 58 1970s 1970s CD cord-104204-pdnkabwj 232 59 ) ) -RRB- cord-104204-pdnkabwj 232 60 showed show VBD cord-104204-pdnkabwj 232 61 the the DT cord-104204-pdnkabwj 232 62 presence presence NN cord-104204-pdnkabwj 232 63 of of IN cord-104204-pdnkabwj 232 64 phenolic phenolic JJ cord-104204-pdnkabwj 232 65 compounds compound NNS cord-104204-pdnkabwj 232 66 in in IN cord-104204-pdnkabwj 232 67 drinking drink VBG cord-104204-pdnkabwj 232 68 well well RB cord-104204-pdnkabwj 232 69 water water NN cord-104204-pdnkabwj 232 70 from from IN cord-104204-pdnkabwj 232 71 endemic endemic JJ cord-104204-pdnkabwj 232 72 regions region NNS cord-104204-pdnkabwj 232 73 in in IN cord-104204-pdnkabwj 232 74 Romania Romania NNP cord-104204-pdnkabwj 232 75 Glogovac Glogovac NNP cord-104204-pdnkabwj 232 76 was be VBD cord-104204-pdnkabwj 232 77 described describe VBN cord-104204-pdnkabwj 232 78 as as IN cord-104204-pdnkabwj 232 79 a a DT cord-104204-pdnkabwj 232 80 model model NN cord-104204-pdnkabwj 232 81 endemic endemic JJ cord-104204-pdnkabwj 232 82 village village NN cord-104204-pdnkabwj 232 83 composed compose VBN cord-104204-pdnkabwj 232 84 of of IN cord-104204-pdnkabwj 232 85 two two CD cord-104204-pdnkabwj 232 86 parts part NNS cord-104204-pdnkabwj 232 87 with with IN cord-104204-pdnkabwj 232 88 similar similar JJ cord-104204-pdnkabwj 232 89 ethnical ethnical JJ cord-104204-pdnkabwj 232 90 groups group NNS cord-104204-pdnkabwj 232 91 , , , cord-104204-pdnkabwj 232 92 socioeconomic socioeconomic JJ cord-104204-pdnkabwj 232 93 status status NN cord-104204-pdnkabwj 232 94 , , , cord-104204-pdnkabwj 232 95 and and CC cord-104204-pdnkabwj 232 96 hydric hydric NN cord-104204-pdnkabwj 232 97 and and CC cord-104204-pdnkabwj 232 98 food food NN cord-104204-pdnkabwj 232 99 preparation preparation NN cord-104204-pdnkabwj 232 100 habits habit NNS cord-104204-pdnkabwj 232 101 , , , cord-104204-pdnkabwj 232 102 but but CC cord-104204-pdnkabwj 232 103 different different JJ cord-104204-pdnkabwj 232 104 in in IN cord-104204-pdnkabwj 232 105 the the DT cord-104204-pdnkabwj 232 106 incidence incidence NN cord-104204-pdnkabwj 232 107 of of IN cord-104204-pdnkabwj 232 108 BEN BEN NNP cord-104204-pdnkabwj 232 109 / / SYM cord-104204-pdnkabwj 232 110 UTT UTT NNP cord-104204-pdnkabwj 232 111 and and CC cord-104204-pdnkabwj 232 112 probably probably RB cord-104204-pdnkabwj 232 113 in in IN cord-104204-pdnkabwj 232 114 the the DT cord-104204-pdnkabwj 232 115 hydrogeological hydrogeological JJ cord-104204-pdnkabwj 232 116 conditions condition NNS cord-104204-pdnkabwj 232 117 and and CC cord-104204-pdnkabwj 232 118 well well JJ cord-104204-pdnkabwj 232 119 water water NN cord-104204-pdnkabwj 232 120 chemistry chemistry NN cord-104204-pdnkabwj 232 121 ( ( -LRB- cord-104204-pdnkabwj 232 122 44 44 CD cord-104204-pdnkabwj 232 123 ) ) -RRB- cord-104204-pdnkabwj 233 1 Hyperendemicity Hyperendemicity NNP cord-104204-pdnkabwj 233 2 of of IN cord-104204-pdnkabwj 233 3 BEN BEN NNP cord-104204-pdnkabwj 233 4 is be VBZ cord-104204-pdnkabwj 233 5 apparently apparently RB cord-104204-pdnkabwj 233 6 linked link VBN cord-104204-pdnkabwj 233 7 to to IN cord-104204-pdnkabwj 233 8 the the DT cord-104204-pdnkabwj 233 9 use use NN cord-104204-pdnkabwj 233 10 of of IN cord-104204-pdnkabwj 233 11 a a DT cord-104204-pdnkabwj 233 12 single single JJ cord-104204-pdnkabwj 233 13 or or CC cord-104204-pdnkabwj 233 14 a a DT cord-104204-pdnkabwj 233 15 few few JJ cord-104204-pdnkabwj 233 16 well well JJ cord-104204-pdnkabwj 233 17 water water NN cord-104204-pdnkabwj 233 18 supplies supply NNS cord-104204-pdnkabwj 233 19 by by IN cord-104204-pdnkabwj 233 20 an an DT cord-104204-pdnkabwj 233 21 entire entire JJ cord-104204-pdnkabwj 233 22 village village NN cord-104204-pdnkabwj 233 23 Semiquantitative Semiquantitative NNP cord-104204-pdnkabwj 233 24 detection detection NN cord-104204-pdnkabwj 233 25 in in IN cord-104204-pdnkabwj 233 26 water water NN cord-104204-pdnkabwj 233 27 samples sample NNS cord-104204-pdnkabwj 233 28 from from IN cord-104204-pdnkabwj 233 29 endemic endemic JJ cord-104204-pdnkabwj 233 30 regions region NNS cord-104204-pdnkabwj 233 31 in in IN cord-104204-pdnkabwj 233 32 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 233 33 revealed reveal VBD cord-104204-pdnkabwj 233 34 the the DT cord-104204-pdnkabwj 233 35 presence presence NN cord-104204-pdnkabwj 233 36 of of IN cord-104204-pdnkabwj 233 37 PAHs pah NNS cord-104204-pdnkabwj 233 38 and and CC cord-104204-pdnkabwj 233 39 aromatic aromatic JJ cord-104204-pdnkabwj 233 40 amines amine NNS cord-104204-pdnkabwj 233 41 not not RB cord-104204-pdnkabwj 233 42 present present JJ cord-104204-pdnkabwj 233 43 in in IN cord-104204-pdnkabwj 233 44 the the DT cord-104204-pdnkabwj 233 45 water water NN cord-104204-pdnkabwj 233 46 samples sample NNS cord-104204-pdnkabwj 233 47 from from IN cord-104204-pdnkabwj 233 48 the the DT cord-104204-pdnkabwj 233 49 nonendemic nonendemic NNP cord-104204-pdnkabwj 233 50 regions region NNS cord-104204-pdnkabwj 233 51 ( ( -LRB- cord-104204-pdnkabwj 233 52 29 29 CD cord-104204-pdnkabwj 233 53 ) ) -RRB- cord-104204-pdnkabwj 234 1 Characteristic characteristic JJ cord-104204-pdnkabwj 234 2 excitation excitation NN cord-104204-pdnkabwj 234 3 / / SYM cord-104204-pdnkabwj 234 4 emission emission NN cord-104204-pdnkabwj 234 5 spectra spectrum NNS cord-104204-pdnkabwj 234 6 were be VBD cord-104204-pdnkabwj 234 7 identified identify VBN cord-104204-pdnkabwj 234 8 in in IN cord-104204-pdnkabwj 234 9 water water NN cord-104204-pdnkabwj 234 10 samples sample NNS cord-104204-pdnkabwj 234 11 from from IN cord-104204-pdnkabwj 234 12 endemic endemic JJ cord-104204-pdnkabwj 234 13 regions region NNS cord-104204-pdnkabwj 234 14 in in IN cord-104204-pdnkabwj 234 15 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 234 16 and and CC cord-104204-pdnkabwj 234 17 Bulgaria Bulgaria NNP cord-104204-pdnkabwj 235 1 ( ( -LRB- cord-104204-pdnkabwj 235 2 40 40 CD cord-104204-pdnkabwj 235 3 ) ) -RRB- cord-104204-pdnkabwj 235 4 PAHs pah NNS cord-104204-pdnkabwj 235 5 were be VBD cord-104204-pdnkabwj 235 6 detected detect VBN cord-104204-pdnkabwj 235 7 by by IN cord-104204-pdnkabwj 235 8 GC GC NNP cord-104204-pdnkabwj 235 9 / / SYM cord-104204-pdnkabwj 235 10 MS MS NNP cord-104204-pdnkabwj 235 11 in in IN cord-104204-pdnkabwj 235 12 higher high JJR cord-104204-pdnkabwj 235 13 concentrations concentration NNS cord-104204-pdnkabwj 235 14 in in IN cord-104204-pdnkabwj 235 15 water water NN cord-104204-pdnkabwj 235 16 samples sample NNS cord-104204-pdnkabwj 235 17 from from IN cord-104204-pdnkabwj 235 18 endemic endemic JJ cord-104204-pdnkabwj 235 19 regions region NNS cord-104204-pdnkabwj 235 20 than than IN cord-104204-pdnkabwj 235 21 in in IN cord-104204-pdnkabwj 235 22 water water NN cord-104204-pdnkabwj 235 23 samples sample NNS cord-104204-pdnkabwj 235 24 from from IN cord-104204-pdnkabwj 235 25 nonendemic nonendemic NNP cord-104204-pdnkabwj 235 26 regions region NNS cord-104204-pdnkabwj 235 27 ( ( -LRB- cord-104204-pdnkabwj 236 1 Orem Orem NNP cord-104204-pdnkabwj 236 2 et et NNP cord-104204-pdnkabwj 236 3 al al NNP cord-104204-pdnkabwj 236 4 . . NNP cord-104204-pdnkabwj 236 5 , , , cord-104204-pdnkabwj 236 6 unpublished unpublished JJ cord-104204-pdnkabwj 236 7 observations observation NNS cord-104204-pdnkabwj 236 8 ) ) -RRB- cord-104204-pdnkabwj 237 1 Laboratory laboratory NN cord-104204-pdnkabwj 237 2 leaching leaching NN cord-104204-pdnkabwj 237 3 experiments experiment NNS cord-104204-pdnkabwj 237 4 showed show VBD cord-104204-pdnkabwj 237 5 the the DT cord-104204-pdnkabwj 237 6 highly highly RB cord-104204-pdnkabwj 237 7 unaltered unaltered JJ cord-104204-pdnkabwj 237 8 character character NN cord-104204-pdnkabwj 237 9 of of IN cord-104204-pdnkabwj 237 10 the the DT cord-104204-pdnkabwj 237 11 Pliocene Pliocene NNP cord-104204-pdnkabwj 237 12 lignites lignite NNS cord-104204-pdnkabwj 237 13 proximal proximal JJ cord-104204-pdnkabwj 237 14 to to IN cord-104204-pdnkabwj 237 15 the the DT cord-104204-pdnkabwj 237 16 endemic endemic JJ cord-104204-pdnkabwj 237 17 regions region NNS cord-104204-pdnkabwj 237 18 in in IN cord-104204-pdnkabwj 237 19 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 237 20 and and CC cord-104204-pdnkabwj 237 21 their -PRON- PRP$ cord-104204-pdnkabwj 237 22 potential potential NN cord-104204-pdnkabwj 237 23 to to TO cord-104204-pdnkabwj 237 24 release release VB cord-104204-pdnkabwj 237 25 PAHs pah NNS cord-104204-pdnkabwj 237 26 and and CC cord-104204-pdnkabwj 237 27 aromatic aromatic JJ cord-104204-pdnkabwj 237 28 compounds compound NNS cord-104204-pdnkabwj 237 29 with with IN cord-104204-pdnkabwj 237 30 functional functional JJ cord-104204-pdnkabwj 237 31 groups group NNS cord-104204-pdnkabwj 237 32 that that WDT cord-104204-pdnkabwj 237 33 can can MD cord-104204-pdnkabwj 237 34 be be VB cord-104204-pdnkabwj 237 35 nephrotoxic nephrotoxic JJ cord-104204-pdnkabwj 237 36 or or CC cord-104204-pdnkabwj 237 37 carcinogenic carcinogenic JJ cord-104204-pdnkabwj 237 38 ( ( -LRB- cord-104204-pdnkabwj 237 39 Orem Orem NNP cord-104204-pdnkabwj 237 40 et et NNP cord-104204-pdnkabwj 237 41 al al NNP cord-104204-pdnkabwj 237 42 . . NNP cord-104204-pdnkabwj 237 43 , , , cord-104204-pdnkabwj 237 44 unpublished unpublished JJ cord-104204-pdnkabwj 237 45 data datum NNS cord-104204-pdnkabwj 237 46 ) ) -RRB- cord-104204-pdnkabwj 238 1 The the DT cord-104204-pdnkabwj 238 2 Pliocene Pliocene NNP cord-104204-pdnkabwj 238 3 lignite lignite NN cord-104204-pdnkabwj 238 4 theory theory NN cord-104204-pdnkabwj 238 5 explains explain VBZ cord-104204-pdnkabwj 238 6 peculiar peculiar JJ cord-104204-pdnkabwj 238 7 features feature NNS cord-104204-pdnkabwj 238 8 of of IN cord-104204-pdnkabwj 238 9 the the DT cord-104204-pdnkabwj 238 10 disease disease NN cord-104204-pdnkabwj 238 11 , , , cord-104204-pdnkabwj 238 12 such such JJ cord-104204-pdnkabwj 238 13 as as IN cord-104204-pdnkabwj 238 14 the the DT cord-104204-pdnkabwj 238 15 geographic geographic JJ cord-104204-pdnkabwj 238 16 confinement confinement NN cord-104204-pdnkabwj 238 17 and and CC cord-104204-pdnkabwj 238 18 the the DT cord-104204-pdnkabwj 238 19 seasonal seasonal JJ cord-104204-pdnkabwj 238 20 variation variation NN cord-104204-pdnkabwj 238 21 in in IN cord-104204-pdnkabwj 238 22 prevalence prevalence NN cord-104204-pdnkabwj 238 23 and and CC cord-104204-pdnkabwj 238 24 death death NN cord-104204-pdnkabwj 238 25 from from IN cord-104204-pdnkabwj 238 26 BEN BEN NNP cord-104204-pdnkabwj 238 27 ; ; : cord-104204-pdnkabwj 238 28 it -PRON- PRP cord-104204-pdnkabwj 238 29 also also RB cord-104204-pdnkabwj 238 30 fits fit VBZ cord-104204-pdnkabwj 238 31 epidemiological epidemiological JJ cord-104204-pdnkabwj 238 32 data datum NNS cord-104204-pdnkabwj 238 33 , , , cord-104204-pdnkabwj 238 34 e.g. e.g. RB cord-104204-pdnkabwj 238 35 , , , cord-104204-pdnkabwj 238 36 the the DT cord-104204-pdnkabwj 238 37 fact fact NN cord-104204-pdnkabwj 238 38 that that IN cord-104204-pdnkabwj 238 39 BEN BEN NNP cord-104204-pdnkabwj 238 40 is be VBZ cord-104204-pdnkabwj 238 41 encountered encounter VBN cord-104204-pdnkabwj 238 42 only only RB cord-104204-pdnkabwj 238 43 in in IN cord-104204-pdnkabwj 238 44 rural rural JJ cord-104204-pdnkabwj 238 45 areas area NNS cord-104204-pdnkabwj 238 46 that that WDT cord-104204-pdnkabwj 238 47 depend depend VBP cord-104204-pdnkabwj 238 48 entirely entirely RB cord-104204-pdnkabwj 238 49 or or CC cord-104204-pdnkabwj 238 50 almost almost RB cord-104204-pdnkabwj 238 51 entirely entirely RB cord-104204-pdnkabwj 238 52 on on IN cord-104204-pdnkabwj 238 53 wells well NNS cord-104204-pdnkabwj 238 54 for for IN cord-104204-pdnkabwj 238 55 drinking drinking NN cord-104204-pdnkabwj 238 56 water water NN cord-104204-pdnkabwj 239 1 The the DT cord-104204-pdnkabwj 239 2 Pliocene Pliocene NNP cord-104204-pdnkabwj 239 3 lignite lignite NN cord-104204-pdnkabwj 239 4 theory theory NN cord-104204-pdnkabwj 239 5 has have VBZ cord-104204-pdnkabwj 239 6 predictive predictive JJ cord-104204-pdnkabwj 239 7 power power NN cord-104204-pdnkabwj 239 8 : : : cord-104204-pdnkabwj 239 9 a a DT cord-104204-pdnkabwj 239 10 previously previously RB cord-104204-pdnkabwj 239 11 unknown unknown JJ cord-104204-pdnkabwj 239 12 BEN BEN NNP cord-104204-pdnkabwj 239 13 region region NN cord-104204-pdnkabwj 239 14 was be VBD cord-104204-pdnkabwj 239 15 identified identify VBN cord-104204-pdnkabwj 239 16 based base VBN cord-104204-pdnkabwj 239 17 on on IN cord-104204-pdnkabwj 239 18 the the DT cord-104204-pdnkabwj 239 19 proximity proximity NN cord-104204-pdnkabwj 239 20 to to IN cord-104204-pdnkabwj 239 21 a a DT cord-104204-pdnkabwj 239 22 Pliocene pliocene JJ cord-104204-pdnkabwj 239 23 coal coal NN cord-104204-pdnkabwj 239 24 field field NN cord-104204-pdnkabwj 239 25 ( ( -LRB- cord-104204-pdnkabwj 239 26 5 5 CD cord-104204-pdnkabwj 239 27 , , , cord-104204-pdnkabwj 239 28 29 29 CD cord-104204-pdnkabwj 239 29 ) ) -RRB- cord-104204-pdnkabwj 240 1 CONs con NNS cord-104204-pdnkabwj 240 2 Pliocene Pliocene NNP cord-104204-pdnkabwj 240 3 lignites lignite NNS cord-104204-pdnkabwj 240 4 also also RB cord-104204-pdnkabwj 240 5 occur occur VBP cord-104204-pdnkabwj 240 6 in in IN cord-104204-pdnkabwj 240 7 regions region NNS cord-104204-pdnkabwj 240 8 outside outside IN cord-104204-pdnkabwj 240 9 the the DT cord-104204-pdnkabwj 240 10 Balkans Balkans NNPS cord-104204-pdnkabwj 240 11 , , , cord-104204-pdnkabwj 240 12 although although IN cord-104204-pdnkabwj 240 13 their -PRON- PRP$ cord-104204-pdnkabwj 240 14 degree degree NN cord-104204-pdnkabwj 240 15 of of IN cord-104204-pdnkabwj 240 16 alteration alteration NN cord-104204-pdnkabwj 240 17 and and CC cord-104204-pdnkabwj 240 18 their -PRON- PRP$ cord-104204-pdnkabwj 240 19 potential potential NN cord-104204-pdnkabwj 240 20 to to TO cord-104204-pdnkabwj 240 21 release release VB cord-104204-pdnkabwj 240 22 nephrotoxic nephrotoxic JJ cord-104204-pdnkabwj 240 23 / / SYM cord-104204-pdnkabwj 240 24 carcinogenic carcinogenic JJ cord-104204-pdnkabwj 240 25 compounds compound NNS cord-104204-pdnkabwj 240 26 in in IN cord-104204-pdnkabwj 240 27 the the DT cord-104204-pdnkabwj 240 28 ground ground NN cord-104204-pdnkabwj 240 29 water water NN cord-104204-pdnkabwj 240 30 may may MD cord-104204-pdnkabwj 240 31 be be VB cord-104204-pdnkabwj 240 32 different different JJ cord-104204-pdnkabwj 240 33 from from IN cord-104204-pdnkabwj 240 34 the the DT cord-104204-pdnkabwj 240 35 lignites lignites NNPS cord-104204-pdnkabwj 240 36 associated associate VBN cord-104204-pdnkabwj 240 37 with with IN cord-104204-pdnkabwj 240 38 the the DT cord-104204-pdnkabwj 240 39 BEN BEN NNP cord-104204-pdnkabwj 240 40 endemic endemic JJ cord-104204-pdnkabwj 240 41 areas area NNS cord-104204-pdnkabwj 240 42 The the DT cord-104204-pdnkabwj 240 43 currently currently RB cord-104204-pdnkabwj 240 44 identified identify VBN cord-104204-pdnkabwj 240 45 PAHs pah NNS cord-104204-pdnkabwj 240 46 and and CC cord-104204-pdnkabwj 240 47 aromatic aromatic JJ cord-104204-pdnkabwj 240 48 compounds compound NNS cord-104204-pdnkabwj 240 49 in in IN cord-104204-pdnkabwj 240 50 the the DT cord-104204-pdnkabwj 240 51 well well NN cord-104204-pdnkabwj 240 52 drinking drinking NN cord-104204-pdnkabwj 240 53 water water NN cord-104204-pdnkabwj 240 54 from from IN cord-104204-pdnkabwj 240 55 the the DT cord-104204-pdnkabwj 240 56 endemic endemic JJ cord-104204-pdnkabwj 240 57 areas area NNS cord-104204-pdnkabwj 240 58 are be VBP cord-104204-pdnkabwj 240 59 not not RB cord-104204-pdnkabwj 240 60 solely solely RB cord-104204-pdnkabwj 240 61 sufficient sufficient JJ cord-104204-pdnkabwj 240 62 to to TO cord-104204-pdnkabwj 240 63 explain explain VB cord-104204-pdnkabwj 240 64 the the DT cord-104204-pdnkabwj 240 65 etiology etiology NN cord-104204-pdnkabwj 240 66 and and CC cord-104204-pdnkabwj 240 67 pathogeny pathogeny NN cord-104204-pdnkabwj 240 68 of of IN cord-104204-pdnkabwj 240 69 BEN BEN NNP cord-104204-pdnkabwj 240 70 / / SYM cord-104204-pdnkabwj 240 71 UTT UTT NNP cord-104204-pdnkabwj 240 72 Future Future NNP cord-104204-pdnkabwj 240 73 Geochemical Geochemical NNP cord-104204-pdnkabwj 240 74 analysis analysis NN cord-104204-pdnkabwj 240 75 of of IN cord-104204-pdnkabwj 240 76 lignites lignites NNPS cord-104204-pdnkabwj 240 77 from from IN cord-104204-pdnkabwj 240 78 Romania Romania NNP cord-104204-pdnkabwj 240 79 and and CC cord-104204-pdnkabwj 240 80 Bulgaria Bulgaria NNP cord-104204-pdnkabwj 240 81 topographically topographically RB cord-104204-pdnkabwj 240 82 linked link VBD cord-104204-pdnkabwj 240 83 to to IN cord-104204-pdnkabwj 240 84 the the DT cord-104204-pdnkabwj 240 85 BEN BEN NNP cord-104204-pdnkabwj 240 86 endemic endemic JJ cord-104204-pdnkabwj 240 87 areas area NNS cord-104204-pdnkabwj 240 88 may may MD cord-104204-pdnkabwj 240 89 be be VB cord-104204-pdnkabwj 240 90 performed perform VBN cord-104204-pdnkabwj 240 91 prospects prospect NNS cord-104204-pdnkabwj 240 92 Compounds compound NNS cord-104204-pdnkabwj 240 93 likely likely JJ cord-104204-pdnkabwj 240 94 to to TO cord-104204-pdnkabwj 240 95 be be VB cord-104204-pdnkabwj 240 96 nephrotoxic nephrotoxic NNP cord-104204-pdnkabwj 240 97 / / SYM cord-104204-pdnkabwj 240 98 carcinogenic carcinogenic JJ cord-104204-pdnkabwj 240 99 , , , cord-104204-pdnkabwj 240 100 such such JJ cord-104204-pdnkabwj 240 101 as as IN cord-104204-pdnkabwj 240 102 aminophenols aminophenol NNS cord-104204-pdnkabwj 240 103 , , , cord-104204-pdnkabwj 240 104 aromatic aromatic JJ cord-104204-pdnkabwj 240 105 amines amine NNS cord-104204-pdnkabwj 240 106 , , , cord-104204-pdnkabwj 240 107 or or CC cord-104204-pdnkabwj 240 108 other other JJ cord-104204-pdnkabwj 240 109 unknown unknown JJ cord-104204-pdnkabwj 240 110 molecules molecule NNS cord-104204-pdnkabwj 240 111 potentially potentially RB cord-104204-pdnkabwj 240 112 leaching leach VBG cord-104204-pdnkabwj 240 113 from from IN cord-104204-pdnkabwj 240 114 the the DT cord-104204-pdnkabwj 240 115 Pliocene Pliocene NNP cord-104204-pdnkabwj 240 116 lignites lignite NNS cord-104204-pdnkabwj 240 117 in in IN cord-104204-pdnkabwj 240 118 the the DT cord-104204-pdnkabwj 240 119 well well JJ cord-104204-pdnkabwj 240 120 water water NN cord-104204-pdnkabwj 240 121 from from IN cord-104204-pdnkabwj 240 122 the the DT cord-104204-pdnkabwj 240 123 endemic endemic JJ cord-104204-pdnkabwj 240 124 regions region NNS cord-104204-pdnkabwj 240 125 , , , cord-104204-pdnkabwj 240 126 may may MD cord-104204-pdnkabwj 240 127 be be VB cord-104204-pdnkabwj 240 128 identified identify VBN cord-104204-pdnkabwj 240 129 Biomarkers Biomarkers NNPS cord-104204-pdnkabwj 240 130 of of IN cord-104204-pdnkabwj 240 131 PAH PAH NNP cord-104204-pdnkabwj 240 132 exposure exposure NN cord-104204-pdnkabwj 240 133 may may MD cord-104204-pdnkabwj 240 134 be be VB cord-104204-pdnkabwj 240 135 assessed assess VBN cord-104204-pdnkabwj 241 1 , , , cord-104204-pdnkabwj 241 2 e.g. e.g. RB cord-104204-pdnkabwj 241 3 , , , cord-104204-pdnkabwj 241 4 PAH PAH NNP cord-104204-pdnkabwj 241 5 - - HYPH cord-104204-pdnkabwj 241 6 DNA dna NN cord-104204-pdnkabwj 241 7 adducts adduct NNS cord-104204-pdnkabwj 241 8 in in IN cord-104204-pdnkabwj 241 9 blood blood NN cord-104204-pdnkabwj 241 10 cell cell NN cord-104204-pdnkabwj 241 11 DNA dna NN cord-104204-pdnkabwj 241 12 samples sample NNS cord-104204-pdnkabwj 241 13 and and CC cord-104204-pdnkabwj 241 14 urinary urinary JJ cord-104204-pdnkabwj 241 15 1-hydroxypyrene 1-hydroxypyrene CD cord-104204-pdnkabwj 241 16 levels level NNS cord-104204-pdnkabwj 241 17 in in IN cord-104204-pdnkabwj 241 18 patients patient NNS cord-104204-pdnkabwj 241 19 with with IN cord-104204-pdnkabwj 241 20 BEN BEN NNP cord-104204-pdnkabwj 241 21 / / SYM cord-104204-pdnkabwj 241 22 UTT UTT NNP cord-104204-pdnkabwj 241 23 An an DT cord-104204-pdnkabwj 241 24 animal animal NN cord-104204-pdnkabwj 241 25 model model NN cord-104204-pdnkabwj 241 26 for for IN cord-104204-pdnkabwj 241 27 BEN BEN NNP cord-104204-pdnkabwj 241 28 might may MD cord-104204-pdnkabwj 241 29 be be VB cord-104204-pdnkabwj 241 30 developed develop VBN cord-104204-pdnkabwj 241 31 by by IN cord-104204-pdnkabwj 241 32 feeding feed VBG cord-104204-pdnkabwj 241 33 laboratory laboratory NN cord-104204-pdnkabwj 241 34 animals animal NNS cord-104204-pdnkabwj 241 35 compounds compound NNS cord-104204-pdnkabwj 241 36 isolated isolate VBN cord-104204-pdnkabwj 241 37 from from IN cord-104204-pdnkabwj 241 38 endemic endemic JJ cord-104204-pdnkabwj 241 39 well well JJ cord-104204-pdnkabwj 241 40 water water NN cord-104204-pdnkabwj 241 41 and/or and/or CC cord-104204-pdnkabwj 241 42 from from IN cord-104204-pdnkabwj 241 43 Pliocene Pliocene NNP cord-104204-pdnkabwj 241 44 lignite lignite NN cord-104204-pdnkabwj 241 45 leachates leachate NNS cord-104204-pdnkabwj 241 46 Abbreviations abbreviation NNS cord-104204-pdnkabwj 241 47 : : : cord-104204-pdnkabwj 242 1 PAHs PAHs NNP cord-104204-pdnkabwj 242 2 , , , cord-104204-pdnkabwj 242 3 polycyclic polycyclic JJ cord-104204-pdnkabwj 242 4 aromatc aromatc NNP cord-104204-pdnkabwj 242 5 hydrocarbons hydrocarbon NNS cord-104204-pdnkabwj 242 6 ; ; : cord-104204-pdnkabwj 242 7 GC GC NNP cord-104204-pdnkabwj 242 8 / / SYM cord-104204-pdnkabwj 242 9 MS MS NNP cord-104204-pdnkabwj 242 10 , , , cord-104204-pdnkabwj 242 11 gas gas NN cord-104204-pdnkabwj 242 12 chromatography chromatography NN cord-104204-pdnkabwj 242 13 / / SYM cord-104204-pdnkabwj 242 14 mass mass NN cord-104204-pdnkabwj 242 15 spectrometry spectrometry NN cord-104204-pdnkabwj 242 16 . . . cord-104204-pdnkabwj 242 17 glomeruli glomerulus NNS cord-104204-pdnkabwj 242 18 ; ; : cord-104204-pdnkabwj 242 19 and and CC cord-104204-pdnkabwj 242 20 mild mild JJ cord-104204-pdnkabwj 242 21 to to TO cord-104204-pdnkabwj 242 22 moderate moderate JJ cord-104204-pdnkabwj 242 23 atypia atypia NN cord-104204-pdnkabwj 242 24 or or CC cord-104204-pdnkabwj 242 25 atypical atypical JJ cord-104204-pdnkabwj 242 26 hyperplasia hyperplasia NN cord-104204-pdnkabwj 242 27 of of IN cord-104204-pdnkabwj 242 28 the the DT cord-104204-pdnkabwj 242 29 urothelium urothelium NN cord-104204-pdnkabwj 242 30 ( ( -LRB- cord-104204-pdnkabwj 242 31 53 53 CD cord-104204-pdnkabwj 242 32 ) ) -RRB- cord-104204-pdnkabwj 242 33 . . . cord-104204-pdnkabwj 243 1 In in IN cord-104204-pdnkabwj 243 2 two two CD cord-104204-pdnkabwj 243 3 cases case NNS cord-104204-pdnkabwj 243 4 of of IN cord-104204-pdnkabwj 243 5 CHN CHN NNP cord-104204-pdnkabwj 243 6 , , , cord-104204-pdnkabwj 243 7 UTTs utt NNS cord-104204-pdnkabwj 243 8 were be VBD cord-104204-pdnkabwj 243 9 described describe VBN cord-104204-pdnkabwj 243 10 , , , cord-104204-pdnkabwj 243 11 providing provide VBG cord-104204-pdnkabwj 243 12 another another DT cord-104204-pdnkabwj 243 13 link link NN cord-104204-pdnkabwj 243 14 to to IN cord-104204-pdnkabwj 243 15 BEN BEN NNP cord-104204-pdnkabwj 243 16 . . . cord-104204-pdnkabwj 244 1 The the DT cord-104204-pdnkabwj 244 2 aristolochic aristolochic JJ cord-104204-pdnkabwj 244 3 acid acid NN cord-104204-pdnkabwj 244 4 hypothesis hypothesis NN cord-104204-pdnkabwj 244 5 nevertheless nevertheless RB cord-104204-pdnkabwj 244 6 fails fail VBZ cord-104204-pdnkabwj 244 7 to to TO cord-104204-pdnkabwj 244 8 explain explain VB cord-104204-pdnkabwj 244 9 one one CD cord-104204-pdnkabwj 244 10 of of IN cord-104204-pdnkabwj 244 11 the the DT cord-104204-pdnkabwj 244 12 defining define VBG cord-104204-pdnkabwj 244 13 features feature NNS cord-104204-pdnkabwj 244 14 of of IN cord-104204-pdnkabwj 244 15 BEN BEN NNP cord-104204-pdnkabwj 244 16 , , , cord-104204-pdnkabwj 244 17 i.e. i.e. FW cord-104204-pdnkabwj 244 18 , , , cord-104204-pdnkabwj 244 19 the the DT cord-104204-pdnkabwj 244 20 geographical geographical JJ cord-104204-pdnkabwj 244 21 confinement confinement NN cord-104204-pdnkabwj 244 22 . . . cord-104204-pdnkabwj 245 1 Aristolochia Aristolochia NNP cord-104204-pdnkabwj 245 2 plants plant NNS cord-104204-pdnkabwj 245 3 are be VBP cord-104204-pdnkabwj 245 4 widely widely RB cord-104204-pdnkabwj 245 5 cultivated cultivate VBN cord-104204-pdnkabwj 245 6 and and CC cord-104204-pdnkabwj 245 7 are be VBP cord-104204-pdnkabwj 245 8 probably probably RB cord-104204-pdnkabwj 245 9 native native JJ cord-104204-pdnkabwj 245 10 in in IN cord-104204-pdnkabwj 245 11 many many JJ cord-104204-pdnkabwj 245 12 places place NNS cord-104204-pdnkabwj 245 13 in in IN cord-104204-pdnkabwj 245 14 Europe Europe NNP cord-104204-pdnkabwj 245 15 , , , cord-104204-pdnkabwj 245 16 Asia Asia NNP cord-104204-pdnkabwj 245 17 , , , cord-104204-pdnkabwj 245 18 and and CC cord-104204-pdnkabwj 245 19 North North NNP cord-104204-pdnkabwj 245 20 America America NNP cord-104204-pdnkabwj 245 21 , , , cord-104204-pdnkabwj 245 22 places place NNS cord-104204-pdnkabwj 245 23 where where WRB cord-104204-pdnkabwj 245 24 no no DT cord-104204-pdnkabwj 245 25 cases case NNS cord-104204-pdnkabwj 245 26 of of IN cord-104204-pdnkabwj 245 27 BEN BEN NNP cord-104204-pdnkabwj 245 28 or or CC cord-104204-pdnkabwj 245 29 a a DT cord-104204-pdnkabwj 245 30 BEN BEN NNP cord-104204-pdnkabwj 245 31 - - HYPH cord-104204-pdnkabwj 245 32 like like JJ cord-104204-pdnkabwj 245 33 disease disease NN cord-104204-pdnkabwj 245 34 have have VBP cord-104204-pdnkabwj 245 35 been be VBN cord-104204-pdnkabwj 245 36 documented document VBN cord-104204-pdnkabwj 245 37 .. .. . cord-104204-pdnkabwj 246 1 Also also RB cord-104204-pdnkabwj 246 2 , , , cord-104204-pdnkabwj 246 3 even even RB cord-104204-pdnkabwj 246 4 though though IN cord-104204-pdnkabwj 246 5 many many JJ cord-104204-pdnkabwj 246 6 herbal herbal JJ cord-104204-pdnkabwj 246 7 remedies remedy NNS cord-104204-pdnkabwj 246 8 are be VBP cord-104204-pdnkabwj 246 9 used use VBN cord-104204-pdnkabwj 246 10 locally locally RB cord-104204-pdnkabwj 246 11 in in IN cord-104204-pdnkabwj 246 12 the the DT cord-104204-pdnkabwj 246 13 BEN BEN NNP cord-104204-pdnkabwj 246 14 areas area NNS cord-104204-pdnkabwj 246 15 , , , cord-104204-pdnkabwj 246 16 it -PRON- PRP cord-104204-pdnkabwj 246 17 is be VBZ cord-104204-pdnkabwj 246 18 unlikely unlikely JJ cord-104204-pdnkabwj 246 19 that that IN cord-104204-pdnkabwj 246 20 Aristolochia Aristolochia NNP cord-104204-pdnkabwj 246 21 leaves leave VBZ cord-104204-pdnkabwj 246 22 , , , cord-104204-pdnkabwj 246 23 seeds seed NNS cord-104204-pdnkabwj 246 24 , , , cord-104204-pdnkabwj 246 25 or or CC cord-104204-pdnkabwj 246 26 roots root NNS cord-104204-pdnkabwj 246 27 are be VBP cord-104204-pdnkabwj 246 28 ingested ingest VBN cord-104204-pdnkabwj 246 29 on on IN cord-104204-pdnkabwj 246 30 such such PDT cord-104204-pdnkabwj 246 31 a a DT cord-104204-pdnkabwj 246 32 widespread widespread JJ cord-104204-pdnkabwj 246 33 scale scale NN cord-104204-pdnkabwj 246 34 in in IN cord-104204-pdnkabwj 246 35 the the DT cord-104204-pdnkabwj 246 36 endemic endemic JJ cord-104204-pdnkabwj 246 37 locations location NNS cord-104204-pdnkabwj 246 38 ( ( -LRB- cord-104204-pdnkabwj 246 39 3 3 CD cord-104204-pdnkabwj 246 40 ) ) -RRB- cord-104204-pdnkabwj 246 41 . . . cord-104204-pdnkabwj 247 1 The the DT cord-104204-pdnkabwj 247 2 pungent pungent JJ cord-104204-pdnkabwj 247 3 repulsive repulsive JJ cord-104204-pdnkabwj 247 4 odor odor NN cord-104204-pdnkabwj 247 5 of of IN cord-104204-pdnkabwj 247 6 the the DT cord-104204-pdnkabwj 247 7 plant plant NN cord-104204-pdnkabwj 247 8 makes make VBZ cord-104204-pdnkabwj 247 9 it -PRON- PRP cord-104204-pdnkabwj 247 10 equally equally RB cord-104204-pdnkabwj 247 11 unlikely unlikely JJ cord-104204-pdnkabwj 247 12 to to TO cord-104204-pdnkabwj 247 13 be be VB cord-104204-pdnkabwj 247 14 accidentally accidentally RB cord-104204-pdnkabwj 247 15 ingested ingest VBN cord-104204-pdnkabwj 247 16 , , , cord-104204-pdnkabwj 247 17 even even RB cord-104204-pdnkabwj 247 18 on on IN cord-104204-pdnkabwj 247 19 an an DT cord-104204-pdnkabwj 247 20 endemic endemic JJ cord-104204-pdnkabwj 247 21 scale scale NN cord-104204-pdnkabwj 247 22 . . . cord-104204-pdnkabwj 248 1 In in IN cord-104204-pdnkabwj 248 2 addition addition NN cord-104204-pdnkabwj 248 3 , , , cord-104204-pdnkabwj 248 4 the the DT cord-104204-pdnkabwj 248 5 pelviureteric pelviureteric JJ cord-104204-pdnkabwj 248 6 sclerosis sclerosis NN cord-104204-pdnkabwj 248 7 found find VBN cord-104204-pdnkabwj 248 8 in in IN cord-104204-pdnkabwj 248 9 one one CD cord-104204-pdnkabwj 248 10 of of IN cord-104204-pdnkabwj 248 11 the the DT cord-104204-pdnkabwj 248 12 biopsied biopsie VBN cord-104204-pdnkabwj 248 13 cases case NNS cord-104204-pdnkabwj 248 14 of of IN cord-104204-pdnkabwj 248 15 Chinese chinese JJ cord-104204-pdnkabwj 248 16 herb herb NN cord-104204-pdnkabwj 248 17 nephropathy nephropathy NN cord-104204-pdnkabwj 248 18 reminds remind VBZ cord-104204-pdnkabwj 248 19 more more JJR cord-104204-pdnkabwj 248 20 of of IN cord-104204-pdnkabwj 248 21 analgesic analgesic JJ cord-104204-pdnkabwj 248 22 nephropathy nephropathy NN cord-104204-pdnkabwj 248 23 than than IN cord-104204-pdnkabwj 248 24 BEN BEN NNP cord-104204-pdnkabwj 248 25 . . . cord-104204-pdnkabwj 249 1 Viruses virus NNS cord-104204-pdnkabwj 250 1 A a DT cord-104204-pdnkabwj 250 2 viral viral JJ cord-104204-pdnkabwj 250 3 etiology etiology NN cord-104204-pdnkabwj 250 4 of of IN cord-104204-pdnkabwj 250 5 BEN BEN NNP cord-104204-pdnkabwj 250 6 was be VBD cord-104204-pdnkabwj 250 7 hypothesized hypothesize VBN cord-104204-pdnkabwj 250 8 based base VBN cord-104204-pdnkabwj 250 9 on on IN cord-104204-pdnkabwj 250 10 the the DT cord-104204-pdnkabwj 250 11 endemic endemic JJ cord-104204-pdnkabwj 250 12 character character NN cord-104204-pdnkabwj 250 13 of of IN cord-104204-pdnkabwj 250 14 the the DT cord-104204-pdnkabwj 250 15 disease disease NN cord-104204-pdnkabwj 250 16 , , , cord-104204-pdnkabwj 250 17 the the DT cord-104204-pdnkabwj 250 18 seasonal seasonal JJ cord-104204-pdnkabwj 250 19 variation variation NN cord-104204-pdnkabwj 250 20 in in IN cord-104204-pdnkabwj 250 21 the the DT cord-104204-pdnkabwj 250 22 incidence incidence NN cord-104204-pdnkabwj 250 23 and and CC cord-104204-pdnkabwj 250 24 deaths death NNS cord-104204-pdnkabwj 250 25 from from IN cord-104204-pdnkabwj 250 26 BEN BEN NNP cord-104204-pdnkabwj 250 27 , , , cord-104204-pdnkabwj 250 28 and and CC cord-104204-pdnkabwj 250 29 on on IN cord-104204-pdnkabwj 250 30 the the DT cord-104204-pdnkabwj 250 31 discovery discovery NN cord-104204-pdnkabwj 250 32 of of IN cord-104204-pdnkabwj 250 33 viral viral JJ cord-104204-pdnkabwj 250 34 particles particle NNS cord-104204-pdnkabwj 250 35 in in IN cord-104204-pdnkabwj 250 36 the the DT cord-104204-pdnkabwj 250 37 kidneys kidney NNS cord-104204-pdnkabwj 250 38 of of IN cord-104204-pdnkabwj 250 39 some some DT cord-104204-pdnkabwj 250 40 afflicted afflict VBN cord-104204-pdnkabwj 250 41 persons person NNS cord-104204-pdnkabwj 250 42 ( ( -LRB- cord-104204-pdnkabwj 250 43 55 55 CD cord-104204-pdnkabwj 250 44 ) ) -RRB- cord-104204-pdnkabwj 250 45 . . . cord-104204-pdnkabwj 251 1 The the DT cord-104204-pdnkabwj 251 2 high high JJ cord-104204-pdnkabwj 251 3 frequency frequency NN cord-104204-pdnkabwj 251 4 of of IN cord-104204-pdnkabwj 251 5 urothelial urothelial JJ cord-104204-pdnkabwj 251 6 tumors tumor NNS cord-104204-pdnkabwj 251 7 in in IN cord-104204-pdnkabwj 251 8 BEN BEN NNP cord-104204-pdnkabwj 251 9 patients patient NNS cord-104204-pdnkabwj 251 10 may may MD cord-104204-pdnkabwj 251 11 also also RB cord-104204-pdnkabwj 251 12 be be VB cord-104204-pdnkabwj 251 13 explained explain VBN cord-104204-pdnkabwj 251 14 by by IN cord-104204-pdnkabwj 251 15 infection infection NN cord-104204-pdnkabwj 251 16 with with IN cord-104204-pdnkabwj 251 17 slow slow JJ cord-104204-pdnkabwj 251 18 oncogenic oncogenic JJ cord-104204-pdnkabwj 251 19 viruses virus NNS cord-104204-pdnkabwj 251 20 . . . cord-104204-pdnkabwj 252 1 Several several JJ cord-104204-pdnkabwj 252 2 viruses virus NNS cord-104204-pdnkabwj 252 3 have have VBP cord-104204-pdnkabwj 252 4 been be VBN cord-104204-pdnkabwj 252 5 considered consider VBN cord-104204-pdnkabwj 252 6 as as IN cord-104204-pdnkabwj 252 7 possible possible JJ cord-104204-pdnkabwj 252 8 agents agent NNS cord-104204-pdnkabwj 252 9 : : : cord-104204-pdnkabwj 252 10 the the DT cord-104204-pdnkabwj 252 11 West West NNP cord-104204-pdnkabwj 252 12 Nile Nile NNP cord-104204-pdnkabwj 252 13 virus virus NN cord-104204-pdnkabwj 252 14 , , , cord-104204-pdnkabwj 252 15 papilloma papilloma NN cord-104204-pdnkabwj 252 16 viruses virus NNS cord-104204-pdnkabwj 252 17 ( ( -LRB- cord-104204-pdnkabwj 252 18 BK BK NNP cord-104204-pdnkabwj 252 19 and and CC cord-104204-pdnkabwj 252 20 SV40 SV40 NNP cord-104204-pdnkabwj 252 21 ) ) -RRB- cord-104204-pdnkabwj 252 22 ( ( -LRB- cord-104204-pdnkabwj 252 23 56 56 CD cord-104204-pdnkabwj 252 24 , , , cord-104204-pdnkabwj 252 25 57 57 CD cord-104204-pdnkabwj 252 26 ) ) -RRB- cord-104204-pdnkabwj 252 27 , , , cord-104204-pdnkabwj 252 28 coronaviruses coronaviruse NNS cord-104204-pdnkabwj 252 29 ( ( -LRB- cord-104204-pdnkabwj 252 30 20 20 CD cord-104204-pdnkabwj 252 31 ) ) -RRB- cord-104204-pdnkabwj 252 32 , , , cord-104204-pdnkabwj 252 33 and and CC cord-104204-pdnkabwj 252 34 arenaviruses arenaviruses NNP cord-104204-pdnkabwj 252 35 ( ( -LRB- cord-104204-pdnkabwj 252 36 58 58 CD cord-104204-pdnkabwj 252 37 ) ) -RRB- cord-104204-pdnkabwj 252 38 . . . cord-104204-pdnkabwj 253 1 An an DT cord-104204-pdnkabwj 253 2 extensive extensive JJ cord-104204-pdnkabwj 253 3 search search NN cord-104204-pdnkabwj 253 4 for for IN cord-104204-pdnkabwj 253 5 these these DT cord-104204-pdnkabwj 253 6 viruses virus NNS cord-104204-pdnkabwj 253 7 in in IN cord-104204-pdnkabwj 253 8 BEN BEN NNP cord-104204-pdnkabwj 253 9 patients patient NNS cord-104204-pdnkabwj 253 10 has have VBZ cord-104204-pdnkabwj 253 11 been be VBN cord-104204-pdnkabwj 253 12 unsuccessful unsuccessful JJ cord-104204-pdnkabwj 253 13 so so RB cord-104204-pdnkabwj 253 14 far far RB cord-104204-pdnkabwj 253 15 . . . cord-104204-pdnkabwj 254 1 For for IN cord-104204-pdnkabwj 254 2 example example NN cord-104204-pdnkabwj 254 3 , , , cord-104204-pdnkabwj 254 4 the the DT cord-104204-pdnkabwj 254 5 West West NNP cord-104204-pdnkabwj 254 6 Nile Nile NNP cord-104204-pdnkabwj 254 7 virus virus NN cord-104204-pdnkabwj 254 8 ( ( -LRB- cord-104204-pdnkabwj 254 9 a a DT cord-104204-pdnkabwj 254 10 mosquito mosquito NN cord-104204-pdnkabwj 254 11 - - HYPH cord-104204-pdnkabwj 254 12 borne bear VBN cord-104204-pdnkabwj 254 13 flavivirus flavivirus NN cord-104204-pdnkabwj 254 14 that that WDT cord-104204-pdnkabwj 254 15 caused cause VBD cord-104204-pdnkabwj 254 16 more more JJR cord-104204-pdnkabwj 254 17 than than IN cord-104204-pdnkabwj 254 18 300 300 CD cord-104204-pdnkabwj 254 19 cases case NNS cord-104204-pdnkabwj 254 20 of of IN cord-104204-pdnkabwj 254 21 meningoencephalitis meningoencephalitis NNP cord-104204-pdnkabwj 254 22 in in IN cord-104204-pdnkabwj 254 23 the the DT cord-104204-pdnkabwj 254 24 Danube Danube NNP cord-104204-pdnkabwj 254 25 flood flood NN cord-104204-pdnkabwj 254 26 lands land NNS cord-104204-pdnkabwj 254 27 , , , cord-104204-pdnkabwj 254 28 including include VBG cord-104204-pdnkabwj 254 29 Bucharest Bucharest NNP cord-104204-pdnkabwj 254 30 , , , cord-104204-pdnkabwj 254 31 Romania Romania NNP cord-104204-pdnkabwj 254 32 , , , cord-104204-pdnkabwj 254 33 in in IN cord-104204-pdnkabwj 254 34 1996 1996 CD cord-104204-pdnkabwj 254 35 ) ) -RRB- cord-104204-pdnkabwj 254 36 , , , cord-104204-pdnkabwj 254 37 is be VBZ cord-104204-pdnkabwj 254 38 probably probably RB cord-104204-pdnkabwj 254 39 not not RB cord-104204-pdnkabwj 254 40 involved involve VBN cord-104204-pdnkabwj 254 41 in in IN cord-104204-pdnkabwj 254 42 BEN BEN NNP cord-104204-pdnkabwj 254 43 because because IN cord-104204-pdnkabwj 254 44 only only RB cord-104204-pdnkabwj 254 45 a a DT cord-104204-pdnkabwj 254 46 few few JJ cord-104204-pdnkabwj 254 47 of of IN cord-104204-pdnkabwj 254 48 the the DT cord-104204-pdnkabwj 254 49 investigated investigate VBN cord-104204-pdnkabwj 254 50 BEN BEN NNP cord-104204-pdnkabwj 254 51 patients patient NNS cord-104204-pdnkabwj 254 52 exhibited exhibit VBD cord-104204-pdnkabwj 254 53 antiviral antiviral JJ cord-104204-pdnkabwj 254 54 antibodies antibody NNS cord-104204-pdnkabwj 254 55 . . . cord-104204-pdnkabwj 255 1 The the DT cord-104204-pdnkabwj 255 2 same same JJ cord-104204-pdnkabwj 255 3 is be VBZ cord-104204-pdnkabwj 255 4 true true JJ cord-104204-pdnkabwj 255 5 for for IN cord-104204-pdnkabwj 255 6 the the DT cord-104204-pdnkabwj 255 7 BK BK NNP cord-104204-pdnkabwj 255 8 and and CC cord-104204-pdnkabwj 255 9 SV40 SV40 NNP cord-104204-pdnkabwj 255 10 viruses virus NNS cord-104204-pdnkabwj 255 11 . . . cord-104204-pdnkabwj 256 1 Although although IN cord-104204-pdnkabwj 256 2 high high JJ cord-104204-pdnkabwj 256 3 titers titer NNS cord-104204-pdnkabwj 256 4 of of IN cord-104204-pdnkabwj 256 5 anti anti JJ cord-104204-pdnkabwj 256 6 - - JJ cord-104204-pdnkabwj 256 7 BK BK NNP cord-104204-pdnkabwj 256 8 and and CC cord-104204-pdnkabwj 256 9 -SV40 -sv40 NN cord-104204-pdnkabwj 256 10 antibodies antibody NNS cord-104204-pdnkabwj 256 11 were be VBD cord-104204-pdnkabwj 256 12 found find VBN cord-104204-pdnkabwj 256 13 in in IN cord-104204-pdnkabwj 256 14 some some DT cord-104204-pdnkabwj 256 15 of of IN cord-104204-pdnkabwj 256 16 the the DT cord-104204-pdnkabwj 256 17 BEN BEN NNP cord-104204-pdnkabwj 256 18 patients patient NNS cord-104204-pdnkabwj 256 19 , , , cord-104204-pdnkabwj 256 20 such such JJ cord-104204-pdnkabwj 256 21 antibodies antibody NNS cord-104204-pdnkabwj 256 22 are be VBP cord-104204-pdnkabwj 256 23 also also RB cord-104204-pdnkabwj 256 24 frequently frequently RB cord-104204-pdnkabwj 256 25 encountered encounter VBN cord-104204-pdnkabwj 256 26 in in IN cord-104204-pdnkabwj 256 27 the the DT cord-104204-pdnkabwj 256 28 general general JJ cord-104204-pdnkabwj 256 29 healthy healthy JJ cord-104204-pdnkabwj 256 30 population population NN cord-104204-pdnkabwj 256 31 . . . cord-104204-pdnkabwj 257 1 Coronaviruses coronaviruse NNS cord-104204-pdnkabwj 257 2 transmitted transmit VBN cord-104204-pdnkabwj 257 3 from from IN cord-104204-pdnkabwj 257 4 pigs pig NNS cord-104204-pdnkabwj 257 5 in in IN cord-104204-pdnkabwj 257 6 the the DT cord-104204-pdnkabwj 257 7 endemic endemic JJ cord-104204-pdnkabwj 257 8 households household NNS cord-104204-pdnkabwj 257 9 were be VBD cord-104204-pdnkabwj 257 10 suggested suggest VBN cord-104204-pdnkabwj 257 11 as as IN cord-104204-pdnkabwj 257 12 a a DT cord-104204-pdnkabwj 257 13 possible possible JJ cord-104204-pdnkabwj 257 14 cause cause NN cord-104204-pdnkabwj 257 15 for for IN cord-104204-pdnkabwj 257 16 BEN BEN NNP cord-104204-pdnkabwj 257 17 ( ( -LRB- cord-104204-pdnkabwj 257 18 20 20 CD cord-104204-pdnkabwj 257 19 ) ) -RRB- cord-104204-pdnkabwj 257 20 . . . cord-104204-pdnkabwj 258 1 However however RB cord-104204-pdnkabwj 258 2 , , , cord-104204-pdnkabwj 258 3 evidence evidence NN cord-104204-pdnkabwj 258 4 supporting support VBG cord-104204-pdnkabwj 258 5 this this DT cord-104204-pdnkabwj 258 6 hypothesis hypothesis NN cord-104204-pdnkabwj 258 7 is be VBZ cord-104204-pdnkabwj 258 8 lacking lack VBG cord-104204-pdnkabwj 258 9 . . . cord-104204-pdnkabwj 259 1 More more RBR cord-104204-pdnkabwj 259 2 likely likely JJ cord-104204-pdnkabwj 259 3 candidates candidate NNS cord-104204-pdnkabwj 259 4 for for IN cord-104204-pdnkabwj 259 5 a a DT cord-104204-pdnkabwj 259 6 viral viral JJ cord-104204-pdnkabwj 259 7 etiology etiology NN cord-104204-pdnkabwj 259 8 are be VBP cord-104204-pdnkabwj 259 9 rodent rodent NN cord-104204-pdnkabwj 259 10 - - HYPH cord-104204-pdnkabwj 259 11 borne bear VBN cord-104204-pdnkabwj 259 12 viruses virus NNS cord-104204-pdnkabwj 259 13 such such JJ cord-104204-pdnkabwj 259 14 as as IN cord-104204-pdnkabwj 259 15 those those DT cord-104204-pdnkabwj 259 16 responsible responsible JJ cord-104204-pdnkabwj 259 17 for for IN cord-104204-pdnkabwj 259 18 hemorrhagic hemorrhagic JJ cord-104204-pdnkabwj 259 19 fever fever NN cord-104204-pdnkabwj 259 20 ( ( -LRB- cord-104204-pdnkabwj 259 21 HF HF NNP cord-104204-pdnkabwj 259 22 ) ) -RRB- cord-104204-pdnkabwj 259 23 syndromes syndrome NNS cord-104204-pdnkabwj 259 24 . . . cord-104204-pdnkabwj 260 1 Some some DT cord-104204-pdnkabwj 260 2 of of IN cord-104204-pdnkabwj 260 3 these these DT cord-104204-pdnkabwj 260 4 viruses virus NNS cord-104204-pdnkabwj 260 5 ( ( -LRB- cord-104204-pdnkabwj 260 6 Puumala Puumala NNP cord-104204-pdnkabwj 260 7 , , , cord-104204-pdnkabwj 260 8 Hantaan Hantaan NNP cord-104204-pdnkabwj 260 9 , , , cord-104204-pdnkabwj 260 10 and and CC cord-104204-pdnkabwj 260 11 Dobrava Dobrava NNP cord-104204-pdnkabwj 260 12 in in IN cord-104204-pdnkabwj 260 13 the the DT cord-104204-pdnkabwj 260 14 Balkans Balkans NNPS cord-104204-pdnkabwj 260 15 ) ) -RRB- cord-104204-pdnkabwj 260 16 can can MD cord-104204-pdnkabwj 260 17 cause cause VB cord-104204-pdnkabwj 260 18 more more RBR cord-104204-pdnkabwj 260 19 or or CC cord-104204-pdnkabwj 260 20 less less RBR cord-104204-pdnkabwj 260 21 severe severe JJ cord-104204-pdnkabwj 260 22 HF HF NNP cord-104204-pdnkabwj 260 23 with with IN cord-104204-pdnkabwj 260 24 renal renal JJ cord-104204-pdnkabwj 260 25 syndrome syndrome NN cord-104204-pdnkabwj 260 26 in in IN cord-104204-pdnkabwj 260 27 rural rural JJ cord-104204-pdnkabwj 260 28 or or CC cord-104204-pdnkabwj 260 29 urban urban JJ cord-104204-pdnkabwj 260 30 areas area NNS cord-104204-pdnkabwj 260 31 . . . cord-104204-pdnkabwj 261 1 The the DT cord-104204-pdnkabwj 261 2 classic classic JJ cord-104204-pdnkabwj 261 3 Hantaan Hantaan NNP cord-104204-pdnkabwj 261 4 disease disease NN cord-104204-pdnkabwj 261 5 in in IN cord-104204-pdnkabwj 261 6 rural rural JJ cord-104204-pdnkabwj 261 7 China China NNP cord-104204-pdnkabwj 261 8 ( ( -LRB- cord-104204-pdnkabwj 261 9 epidemic epidemic NN cord-104204-pdnkabwj 261 10 HF HF NNP cord-104204-pdnkabwj 261 11 ) ) -RRB- cord-104204-pdnkabwj 262 1 and and CC cord-104204-pdnkabwj 262 2 in in IN cord-104204-pdnkabwj 262 3 Korea Korea NNP cord-104204-pdnkabwj 262 4 ( ( -LRB- cord-104204-pdnkabwj 262 5 Korean korean JJ cord-104204-pdnkabwj 262 6 HF HF NNP cord-104204-pdnkabwj 262 7 ) ) -RRB- cord-104204-pdnkabwj 262 8 has have VBZ cord-104204-pdnkabwj 262 9 a a DT cord-104204-pdnkabwj 262 10 seasonal seasonal JJ cord-104204-pdnkabwj 262 11 pattern pattern NN cord-104204-pdnkabwj 262 12 of of IN cord-104204-pdnkabwj 262 13 incidence incidence NN cord-104204-pdnkabwj 262 14 , , , cord-104204-pdnkabwj 262 15 being be VBG cord-104204-pdnkabwj 262 16 most most RBS cord-104204-pdnkabwj 262 17 common common JJ cord-104204-pdnkabwj 262 18 in in IN cord-104204-pdnkabwj 262 19 spring spring NN cord-104204-pdnkabwj 262 20 or or CC cord-104204-pdnkabwj 262 21 fall fall VB cord-104204-pdnkabwj 262 22 , , , cord-104204-pdnkabwj 262 23 possibly possibly RB cord-104204-pdnkabwj 262 24 in in IN cord-104204-pdnkabwj 262 25 relation relation NN cord-104204-pdnkabwj 262 26 to to IN cord-104204-pdnkabwj 262 27 agricultural agricultural JJ cord-104204-pdnkabwj 262 28 practices practice NNS cord-104204-pdnkabwj 262 29 and and CC cord-104204-pdnkabwj 262 30 rodent rodent NN cord-104204-pdnkabwj 262 31 density density NN cord-104204-pdnkabwj 262 32 ( ( -LRB- cord-104204-pdnkabwj 262 33 59 59 CD cord-104204-pdnkabwj 262 34 ) ) -RRB- cord-104204-pdnkabwj 262 35 . . . cord-104204-pdnkabwj 263 1 Infection infection NN cord-104204-pdnkabwj 263 2 in in IN cord-104204-pdnkabwj 263 3 humans human NNS cord-104204-pdnkabwj 263 4 is be VBZ cord-104204-pdnkabwj 263 5 acquired acquire VBN cord-104204-pdnkabwj 263 6 through through IN cord-104204-pdnkabwj 263 7 aerosols aerosol NNS cord-104204-pdnkabwj 263 8 of of IN cord-104204-pdnkabwj 263 9 rodent rodent NN cord-104204-pdnkabwj 263 10 urine urine NN cord-104204-pdnkabwj 263 11 ; ; : cord-104204-pdnkabwj 263 12 the the DT cord-104204-pdnkabwj 263 13 disease disease NN cord-104204-pdnkabwj 263 14 is be VBZ cord-104204-pdnkabwj 263 15 not not RB cord-104204-pdnkabwj 263 16 transmitted transmit VBN cord-104204-pdnkabwj 263 17 from from IN cord-104204-pdnkabwj 263 18 human human JJ cord-104204-pdnkabwj 263 19 to to IN cord-104204-pdnkabwj 263 20 human human NN cord-104204-pdnkabwj 263 21 . . . cord-104204-pdnkabwj 264 1 Some some DT cord-104204-pdnkabwj 264 2 of of IN cord-104204-pdnkabwj 264 3 the the DT cord-104204-pdnkabwj 264 4 features feature NNS cord-104204-pdnkabwj 264 5 of of IN cord-104204-pdnkabwj 264 6 Hantaan Hantaan NNP cord-104204-pdnkabwj 264 7 HF HF NNP cord-104204-pdnkabwj 264 8 are be VBP cord-104204-pdnkabwj 264 9 seen see VBN cord-104204-pdnkabwj 264 10 in in IN cord-104204-pdnkabwj 264 11 BEN BEN NNP cord-104204-pdnkabwj 264 12 - - HYPH cord-104204-pdnkabwj 264 13 disease disease NNP cord-104204-pdnkabwj 264 14 endemicity endemicity NN cord-104204-pdnkabwj 264 15 , , , cord-104204-pdnkabwj 264 16 incidence incidence NN cord-104204-pdnkabwj 264 17 in in IN cord-104204-pdnkabwj 264 18 rural rural JJ cord-104204-pdnkabwj 264 19 settlements settlement NNS cord-104204-pdnkabwj 264 20 , , , cord-104204-pdnkabwj 264 21 and and CC cord-104204-pdnkabwj 264 22 seasonal seasonal JJ cord-104204-pdnkabwj 264 23 variation variation NN cord-104204-pdnkabwj 264 24 - - : cord-104204-pdnkabwj 264 25 but but CC cord-104204-pdnkabwj 264 26 BEN BEN NNP cord-104204-pdnkabwj 264 27 is be VBZ cord-104204-pdnkabwj 264 28 primarily primarily RB cord-104204-pdnkabwj 264 29 a a DT cord-104204-pdnkabwj 264 30 chronic chronic JJ cord-104204-pdnkabwj 264 31 kidney kidney NN cord-104204-pdnkabwj 264 32 disease disease NN cord-104204-pdnkabwj 264 33 without without IN cord-104204-pdnkabwj 264 34 any any DT cord-104204-pdnkabwj 264 35 acute acute JJ cord-104204-pdnkabwj 264 36 episode episode NN cord-104204-pdnkabwj 264 37 in in IN cord-104204-pdnkabwj 264 38 its -PRON- PRP$ cord-104204-pdnkabwj 264 39 evolution evolution NN cord-104204-pdnkabwj 264 40 . . . cord-104204-pdnkabwj 265 1 In in IN cord-104204-pdnkabwj 265 2 contrast contrast NN cord-104204-pdnkabwj 265 3 , , , cord-104204-pdnkabwj 265 4 the the DT cord-104204-pdnkabwj 265 5 Hantaan Hantaan NNP cord-104204-pdnkabwj 265 6 infection infection NN cord-104204-pdnkabwj 265 7 usually usually RB cord-104204-pdnkabwj 265 8 evolves evolve VBZ cord-104204-pdnkabwj 265 9 with with IN cord-104204-pdnkabwj 265 10 acute acute JJ cord-104204-pdnkabwj 265 11 renal renal JJ cord-104204-pdnkabwj 265 12 failure failure NN cord-104204-pdnkabwj 265 13 . . . cord-104204-pdnkabwj 266 1 There there EX cord-104204-pdnkabwj 266 2 is be VBZ cord-104204-pdnkabwj 266 3 an an DT cord-104204-pdnkabwj 266 4 analogy analogy NN cord-104204-pdnkabwj 266 5 worth worth JJ cord-104204-pdnkabwj 266 6 mentioning mention VBG cord-104204-pdnkabwj 266 7 between between IN cord-104204-pdnkabwj 266 8 BEN BEN NNP cord-104204-pdnkabwj 266 9 and and CC cord-104204-pdnkabwj 266 10 the the DT cord-104204-pdnkabwj 266 11 Bolivian bolivian JJ cord-104204-pdnkabwj 266 12 hemorrhagic hemorrhagic JJ cord-104204-pdnkabwj 266 13 fever fever NN cord-104204-pdnkabwj 266 14 , , , cord-104204-pdnkabwj 266 15 an an DT cord-104204-pdnkabwj 266 16 arenaviral arenaviral JJ cord-104204-pdnkabwj 266 17 HF HF NNP cord-104204-pdnkabwj 266 18 disease disease NN cord-104204-pdnkabwj 266 19 spread spread VBN cord-104204-pdnkabwj 266 20 by by IN cord-104204-pdnkabwj 266 21 rodents rodent NNS cord-104204-pdnkabwj 266 22 ( ( -LRB- cord-104204-pdnkabwj 266 23 58 58 CD cord-104204-pdnkabwj 266 24 ) ) -RRB- cord-104204-pdnkabwj 266 25 . . . cord-104204-pdnkabwj 267 1 As as IN cord-104204-pdnkabwj 267 2 discussed discuss VBN cord-104204-pdnkabwj 267 3 by by IN cord-104204-pdnkabwj 267 4 Radovanovic Radovanovic NNP cord-104204-pdnkabwj 267 5 ( ( -LRB- cord-104204-pdnkabwj 267 6 58 58 CD cord-104204-pdnkabwj 267 7 ) ) -RRB- cord-104204-pdnkabwj 267 8 , , , cord-104204-pdnkabwj 267 9 both both DT cord-104204-pdnkabwj 267 10 diseases disease NNS cord-104204-pdnkabwj 267 11 are be VBP cord-104204-pdnkabwj 267 12 characterized characterize VBN cord-104204-pdnkabwj 267 13 by by IN cord-104204-pdnkabwj 267 14 similarities similarity NNS cord-104204-pdnkabwj 267 15 in in IN cord-104204-pdnkabwj 267 16 the the DT cord-104204-pdnkabwj 267 17 topography topography NN cord-104204-pdnkabwj 267 18 of of IN cord-104204-pdnkabwj 267 19 the the DT cord-104204-pdnkabwj 267 20 disease disease NN cord-104204-pdnkabwj 267 21 area area NN cord-104204-pdnkabwj 267 22 ( ( -LRB- cord-104204-pdnkabwj 267 23 flat flat JJ cord-104204-pdnkabwj 267 24 plains plain NNS cord-104204-pdnkabwj 267 25 , , , cord-104204-pdnkabwj 267 26 in in IN cord-104204-pdnkabwj 267 27 river river NN cord-104204-pdnkabwj 267 28 or or CC cord-104204-pdnkabwj 267 29 stream stream NN cord-104204-pdnkabwj 267 30 valleys valley NNS cord-104204-pdnkabwj 267 31 ) ) -RRB- cord-104204-pdnkabwj 267 32 , , , cord-104204-pdnkabwj 267 33 clustering cluster VBG cord-104204-pdnkabwj 267 34 only only RB cord-104204-pdnkabwj 267 35 in in IN cord-104204-pdnkabwj 267 36 certain certain JJ cord-104204-pdnkabwj 267 37 setdements setdement NNS cord-104204-pdnkabwj 267 38 and and CC cord-104204-pdnkabwj 267 39 households household NNS cord-104204-pdnkabwj 267 40 , , , cord-104204-pdnkabwj 267 41 lack lack NN cord-104204-pdnkabwj 267 42 of of IN cord-104204-pdnkabwj 267 43 evidence evidence NN cord-104204-pdnkabwj 267 44 of of IN cord-104204-pdnkabwj 267 45 human human NN cord-104204-pdnkabwj 267 46 - - HYPH cord-104204-pdnkabwj 267 47 to to IN cord-104204-pdnkabwj 267 48 - - HYPH cord-104204-pdnkabwj 267 49 human human JJ cord-104204-pdnkabwj 267 50 transmission transmission NN cord-104204-pdnkabwj 267 51 , , , cord-104204-pdnkabwj 267 52 and and CC cord-104204-pdnkabwj 267 53 the the DT cord-104204-pdnkabwj 267 54 first first JJ cord-104204-pdnkabwj 267 55 recognition recognition NN cord-104204-pdnkabwj 267 56 of of IN cord-104204-pdnkabwj 267 57 both both DT cord-104204-pdnkabwj 267 58 diseases disease NNS cord-104204-pdnkabwj 267 59 after after IN cord-104204-pdnkabwj 267 60 the the DT cord-104204-pdnkabwj 267 61 beginning beginning NN cord-104204-pdnkabwj 267 62 of of IN cord-104204-pdnkabwj 267 63 malaria malaria NN cord-104204-pdnkabwj 267 64 control control NN cord-104204-pdnkabwj 267 65 programs program NNS cord-104204-pdnkabwj 267 66 using use VBG cord-104204-pdnkabwj 267 67 DDT DDT NNP cord-104204-pdnkabwj 267 68 after after IN cord-104204-pdnkabwj 267 69 World World NNP cord-104204-pdnkabwj 267 70 War War NNP cord-104204-pdnkabwj 267 71 II II NNP cord-104204-pdnkabwj 267 72 . . . cord-104204-pdnkabwj 268 1 Although although IN cord-104204-pdnkabwj 268 2 the the DT cord-104204-pdnkabwj 268 3 evidence evidence NN cord-104204-pdnkabwj 268 4 is be VBZ cord-104204-pdnkabwj 268 5 speculative speculative JJ cord-104204-pdnkabwj 268 6 , , , cord-104204-pdnkabwj 268 7 Radovanovic Radovanovic NNP cord-104204-pdnkabwj 268 8 ( ( -LRB- cord-104204-pdnkabwj 268 9 58 58 CD cord-104204-pdnkabwj 268 10 ) ) -RRB- cord-104204-pdnkabwj 268 11 postulates postulate VBZ cord-104204-pdnkabwj 268 12 that that IN cord-104204-pdnkabwj 268 13 residual residual JJ cord-104204-pdnkabwj 268 14 DDT DDT NNP cord-104204-pdnkabwj 268 15 sprayed spray VBN cord-104204-pdnkabwj 268 16 in in IN cord-104204-pdnkabwj 268 17 the the DT cord-104204-pdnkabwj 268 18 Balkans Balkans NNPS cord-104204-pdnkabwj 268 19 in in IN cord-104204-pdnkabwj 268 20 the the DT cord-104204-pdnkabwj 268 21 mid-1940s mid-1940 NNS cord-104204-pdnkabwj 268 22 led lead VBD cord-104204-pdnkabwj 268 23 to to IN cord-104204-pdnkabwj 268 24 the the DT cord-104204-pdnkabwj 268 25 reduction reduction NN cord-104204-pdnkabwj 268 26 in in IN cord-104204-pdnkabwj 268 27 the the DT cord-104204-pdnkabwj 268 28 number number NN cord-104204-pdnkabwj 268 29 of of IN cord-104204-pdnkabwj 268 30 cats cat NNS cord-104204-pdnkabwj 268 31 , , , cord-104204-pdnkabwj 268 32 the the DT cord-104204-pdnkabwj 268 33 most most RBS cord-104204-pdnkabwj 268 34 important important JJ cord-104204-pdnkabwj 268 35 natural natural JJ cord-104204-pdnkabwj 268 36 barrier barrier NN cord-104204-pdnkabwj 268 37 against against IN cord-104204-pdnkabwj 268 38 rodents rodent NNS cord-104204-pdnkabwj 268 39 in in IN cord-104204-pdnkabwj 268 40 the the DT cord-104204-pdnkabwj 268 41 endemic endemic JJ cord-104204-pdnkabwj 268 42 ( ( -LRB- cord-104204-pdnkabwj 268 43 and and CC cord-104204-pdnkabwj 268 44 nonendemic nonendemic NNP cord-104204-pdnkabwj 268 45 ) ) -RRB- cord-104204-pdnkabwj 268 46 households household NNS cord-104204-pdnkabwj 268 47 . . . cord-104204-pdnkabwj 269 1 As as IN cord-104204-pdnkabwj 269 2 a a DT cord-104204-pdnkabwj 269 3 result result NN cord-104204-pdnkabwj 269 4 , , , cord-104204-pdnkabwj 269 5 a a DT cord-104204-pdnkabwj 269 6 decade decade NN cord-104204-pdnkabwj 269 7 later later RBR cord-104204-pdnkabwj 269 8 , , , cord-104204-pdnkabwj 269 9 the the DT cord-104204-pdnkabwj 269 10 rodent rodent NN cord-104204-pdnkabwj 269 11 reservoir reservoir NN cord-104204-pdnkabwj 269 12 expanded expand VBD cord-104204-pdnkabwj 269 13 and and CC cord-104204-pdnkabwj 269 14 BEN BEN NNP cord-104204-pdnkabwj 269 15 emerged emerge VBD cord-104204-pdnkabwj 269 16 and and CC cord-104204-pdnkabwj 269 17 was be VBD cord-104204-pdnkabwj 269 18 described describe VBN cord-104204-pdnkabwj 269 19 for for IN cord-104204-pdnkabwj 269 20 the the DT cord-104204-pdnkabwj 269 21 first first JJ cord-104204-pdnkabwj 269 22 time time NN cord-104204-pdnkabwj 269 23 as as IN cord-104204-pdnkabwj 269 24 a a DT cord-104204-pdnkabwj 269 25 disease disease NN cord-104204-pdnkabwj 269 26 entity entity NN cord-104204-pdnkabwj 269 27 . . . cord-104204-pdnkabwj 270 1 Although although IN cord-104204-pdnkabwj 270 2 improbable improbable JJ cord-104204-pdnkabwj 270 3 based base VBN cord-104204-pdnkabwj 270 4 on on IN cord-104204-pdnkabwj 270 5 the the DT cord-104204-pdnkabwj 270 6 previously previously RB cord-104204-pdnkabwj 270 7 mentioned mention VBN cord-104204-pdnkabwj 270 8 findings finding NNS cord-104204-pdnkabwj 270 9 , , , cord-104204-pdnkabwj 270 10 a a DT cord-104204-pdnkabwj 270 11 viral viral JJ cord-104204-pdnkabwj 270 12 etiology etiology NN cord-104204-pdnkabwj 270 13 for for IN cord-104204-pdnkabwj 270 14 BEN BEN NNP cord-104204-pdnkabwj 270 15 can can MD cord-104204-pdnkabwj 270 16 not not RB cord-104204-pdnkabwj 270 17 be be VB cord-104204-pdnkabwj 270 18 completely completely RB cord-104204-pdnkabwj 270 19 rejected reject VBN cord-104204-pdnkabwj 270 20 until until IN cord-104204-pdnkabwj 270 21 more more JJR cord-104204-pdnkabwj 270 22 comprehensive comprehensive JJ cord-104204-pdnkabwj 270 23 studies study NNS cord-104204-pdnkabwj 270 24 are be VBP cord-104204-pdnkabwj 270 25 available available JJ cord-104204-pdnkabwj 270 26 . . . cord-104204-pdnkabwj 271 1 In in IN cord-104204-pdnkabwj 271 2 a a DT cord-104204-pdnkabwj 271 3 broader broad JJR cord-104204-pdnkabwj 271 4 framework framework NN cord-104204-pdnkabwj 271 5 , , , cord-104204-pdnkabwj 271 6 BEN BEN NNP cord-104204-pdnkabwj 271 7 and and CC cord-104204-pdnkabwj 271 8 its -PRON- PRP$ cord-104204-pdnkabwj 271 9 associated associate VBN cord-104204-pdnkabwj 271 10 UTTs utt NNS cord-104204-pdnkabwj 271 11 would would MD cord-104204-pdnkabwj 271 12 not not RB cord-104204-pdnkabwj 271 13 be be VB cord-104204-pdnkabwj 271 14 unique unique JJ cord-104204-pdnkabwj 271 15 in in IN cord-104204-pdnkabwj 271 16 having have VBG cord-104204-pdnkabwj 271 17 a a DT cord-104204-pdnkabwj 271 18 hydrogeological hydrogeological JJ cord-104204-pdnkabwj 271 19 etiology etiology NN cord-104204-pdnkabwj 271 20 . . . cord-104204-pdnkabwj 272 1 For for IN cord-104204-pdnkabwj 272 2 instance instance NN cord-104204-pdnkabwj 272 3 , , , cord-104204-pdnkabwj 272 4 the the DT cord-104204-pdnkabwj 272 5 field field NN cord-104204-pdnkabwj 272 6 of of IN cord-104204-pdnkabwj 272 7 geomedicine geomedicine NN cord-104204-pdnkabwj 272 8 also also RB cord-104204-pdnkabwj 272 9 records record VBZ cord-104204-pdnkabwj 272 10 a a DT cord-104204-pdnkabwj 272 11 possible possible JJ cord-104204-pdnkabwj 272 12 correlation correlation NN cord-104204-pdnkabwj 272 13 between between IN cord-104204-pdnkabwj 272 14 digestive digestive JJ cord-104204-pdnkabwj 272 15 cancer cancer NN cord-104204-pdnkabwj 272 16 mortality mortality NN cord-104204-pdnkabwj 272 17 rates rate NNS cord-104204-pdnkabwj 272 18 and and CC cord-104204-pdnkabwj 272 19 the the DT cord-104204-pdnkabwj 272 20 consumption consumption NN cord-104204-pdnkabwj 272 21 ofwater ofwater NN cord-104204-pdnkabwj 272 22 from from IN cord-104204-pdnkabwj 272 23 coal coal NN cord-104204-pdnkabwj 272 24 bearing bearing NN cord-104204-pdnkabwj 272 25 strata strata NN cord-104204-pdnkabwj 272 26 ( ( -LRB- cord-104204-pdnkabwj 272 27 60 60 CD cord-104204-pdnkabwj 272 28 ) ) -RRB- cord-104204-pdnkabwj 272 29 . . . cord-104204-pdnkabwj 273 1 From from IN cord-104204-pdnkabwj 273 2 the the DT cord-104204-pdnkabwj 273 3 BEN BEN NNP cord-104204-pdnkabwj 273 4 and and CC cord-104204-pdnkabwj 273 5 UTT UTT NNP cord-104204-pdnkabwj 273 6 perspective perspective NN cord-104204-pdnkabwj 273 7 , , , cord-104204-pdnkabwj 273 8 an an DT cord-104204-pdnkabwj 273 9 intriguing intriguing JJ cord-104204-pdnkabwj 273 10 observation observation NN cord-104204-pdnkabwj 273 11 is be VBZ cord-104204-pdnkabwj 273 12 that that IN cord-104204-pdnkabwj 273 13 the the DT cord-104204-pdnkabwj 273 14 top top JJ cord-104204-pdnkabwj 273 15 five five CD cord-104204-pdnkabwj 273 16 states state NNS cord-104204-pdnkabwj 273 17 in in IN cord-104204-pdnkabwj 273 18 the the DT cord-104204-pdnkabwj 273 19 United United NNP cord-104204-pdnkabwj 273 20 States States NNP cord-104204-pdnkabwj 273 21 in in IN cord-104204-pdnkabwj 273 22 average average JJ cord-104204-pdnkabwj 273 23 annual annual JJ cord-104204-pdnkabwj 273 24 age age NN cord-104204-pdnkabwj 273 25 - - HYPH cord-104204-pdnkabwj 273 26 adjusted adjust VBN cord-104204-pdnkabwj 273 27 cancer cancer NN cord-104204-pdnkabwj 273 28 mortality mortality NN cord-104204-pdnkabwj 273 29 rates rate NNS cord-104204-pdnkabwj 273 30 from from IN cord-104204-pdnkabwj 273 31 kidney kidney NN cord-104204-pdnkabwj 273 32 and and CC cord-104204-pdnkabwj 273 33 renal renal JJ cord-104204-pdnkabwj 273 34 pelvis pelvi NNS cord-104204-pdnkabwj 273 35 cancer cancer NN cord-104204-pdnkabwj 273 36 ( ( -LRB- cord-104204-pdnkabwj 273 37 1989 1989 CD cord-104204-pdnkabwj 273 38 ) ) -RRB- cord-104204-pdnkabwj 273 39 ( ( -LRB- cord-104204-pdnkabwj 273 40 1990 1990 CD cord-104204-pdnkabwj 273 41 ) ) -RRB- cord-104204-pdnkabwj 273 42 ( ( -LRB- cord-104204-pdnkabwj 273 43 1991 1991 CD cord-104204-pdnkabwj 273 44 ) ) -RRB- cord-104204-pdnkabwj 273 45 ( ( -LRB- cord-104204-pdnkabwj 273 46 1992 1992 CD cord-104204-pdnkabwj 273 47 ) ) -RRB- cord-104204-pdnkabwj 273 48 ( ( -LRB- cord-104204-pdnkabwj 273 49 1993 1993 CD cord-104204-pdnkabwj 273 50 ) ) -RRB- cord-104204-pdnkabwj 273 51 are be VBP cord-104204-pdnkabwj 273 52 Alaska Alaska NNP cord-104204-pdnkabwj 273 53 , , , cord-104204-pdnkabwj 273 54 Maine Maine NNP cord-104204-pdnkabwj 273 55 , , , cord-104204-pdnkabwj 273 56 North North NNP cord-104204-pdnkabwj 273 57 Dakota Dakota NNP cord-104204-pdnkabwj 273 58 , , , cord-104204-pdnkabwj 273 59 South South NNP cord-104204-pdnkabwj 273 60 Dakota Dakota NNP cord-104204-pdnkabwj 273 61 , , , cord-104204-pdnkabwj 273 62 and and CC cord-104204-pdnkabwj 273 63 Minnesota Minnesota NNP cord-104204-pdnkabwj 273 64 . . . cord-104204-pdnkabwj 274 1 North north JJ cord-104204-pdnkabwj 274 2 and and CC cord-104204-pdnkabwj 274 3 South South NNP cord-104204-pdnkabwj 274 4 Dakota Dakota NNP cord-104204-pdnkabwj 274 5 have have VBP cord-104204-pdnkabwj 274 6 extensive extensive JJ cord-104204-pdnkabwj 274 7 lignite lignite NN cord-104204-pdnkabwj 274 8 deposits deposit NNS cord-104204-pdnkabwj 274 9 and and CC cord-104204-pdnkabwj 274 10 a a DT cord-104204-pdnkabwj 274 11 largely largely RB cord-104204-pdnkabwj 274 12 rural rural JJ cord-104204-pdnkabwj 274 13 population population NN cord-104204-pdnkabwj 274 14 dependent dependent JJ cord-104204-pdnkabwj 274 15 on on IN cord-104204-pdnkabwj 274 16 wells well NNS cord-104204-pdnkabwj 274 17 as as IN cord-104204-pdnkabwj 274 18 a a DT cord-104204-pdnkabwj 274 19 water water NN cord-104204-pdnkabwj 274 20 source source NN cord-104204-pdnkabwj 274 21 . . . cord-104204-pdnkabwj 275 1 Alaska Alaska NNP cord-104204-pdnkabwj 275 2 , , , cord-104204-pdnkabwj 275 3 Maine Maine NNP cord-104204-pdnkabwj 275 4 , , , cord-104204-pdnkabwj 275 5 and and CC cord-104204-pdnkabwj 275 6 Minnesota Minnesota NNP cord-104204-pdnkabwj 275 7 have have VBP cord-104204-pdnkabwj 275 8 extensive extensive JJ cord-104204-pdnkabwj 275 9 peat peat NN cord-104204-pdnkabwj 275 10 deposits deposit NNS cord-104204-pdnkabwj 275 11 ( ( -LRB- cord-104204-pdnkabwj 275 12 coal coal NN cord-104204-pdnkabwj 275 13 precursors precursor NNS cord-104204-pdnkabwj 275 14 ) ) -RRB- cord-104204-pdnkabwj 275 15 and and CC cord-104204-pdnkabwj 275 16 also also RB cord-104204-pdnkabwj 275 17 considerable considerable JJ cord-104204-pdnkabwj 275 18 rural rural JJ cord-104204-pdnkabwj 275 19 populations population NNS cord-104204-pdnkabwj 275 20 . . . cord-104204-pdnkabwj 276 1 Coal coal NN cord-104204-pdnkabwj 276 2 is be VBZ cord-104204-pdnkabwj 276 3 also also RB cord-104204-pdnkabwj 276 4 considered consider VBN cord-104204-pdnkabwj 276 5 to to TO cord-104204-pdnkabwj 276 6 be be VB cord-104204-pdnkabwj 276 7 an an DT cord-104204-pdnkabwj 276 8 environmental environmental JJ cord-104204-pdnkabwj 276 9 component component NN cord-104204-pdnkabwj 276 10 in in IN cord-104204-pdnkabwj 276 11 the the DT cord-104204-pdnkabwj 276 12 multicausal multicausal NN cord-104204-pdnkabwj 276 13 etiology etiology NN cord-104204-pdnkabwj 276 14 of of IN cord-104204-pdnkabwj 276 15 other other JJ cord-104204-pdnkabwj 276 16 common common JJ cord-104204-pdnkabwj 276 17 diseases disease NNS cord-104204-pdnkabwj 276 18 besides besides IN cord-104204-pdnkabwj 276 19 cancer cancer NN cord-104204-pdnkabwj 276 20 . . . cord-104204-pdnkabwj 277 1 An an DT cord-104204-pdnkabwj 277 2 increased increase VBN cord-104204-pdnkabwj 277 3 rate rate NN cord-104204-pdnkabwj 277 4 of of IN cord-104204-pdnkabwj 277 5 heart heart NN cord-104204-pdnkabwj 277 6 attacks attack NNS cord-104204-pdnkabwj 277 7 is be VBZ cord-104204-pdnkabwj 277 8 encountered encounter VBN cord-104204-pdnkabwj 277 9 in in IN cord-104204-pdnkabwj 277 10 Ohio Ohio NNP cord-104204-pdnkabwj 277 11 , , , cord-104204-pdnkabwj 277 12 correlated correlate VBN cord-104204-pdnkabwj 277 13 with with IN cord-104204-pdnkabwj 277 14 the the DT cord-104204-pdnkabwj 277 15 consumption consumption NN cord-104204-pdnkabwj 277 16 of of IN cord-104204-pdnkabwj 277 17 drinking drink VBG cord-104204-pdnkabwj 277 18 water water NN cord-104204-pdnkabwj 277 19 from from IN cord-104204-pdnkabwj 277 20 coal coal NN cord-104204-pdnkabwj 277 21 - - HYPH cord-104204-pdnkabwj 277 22 bearing bear VBG cord-104204-pdnkabwj 277 23 strata strata NN cord-104204-pdnkabwj 277 24 ( ( -LRB- cord-104204-pdnkabwj 277 25 61 61 CD cord-104204-pdnkabwj 277 26 ) ) -RRB- cord-104204-pdnkabwj 277 27 . . . cord-104204-pdnkabwj 278 1 A a DT cord-104204-pdnkabwj 278 2 significant significant JJ cord-104204-pdnkabwj 278 3 negative negative JJ cord-104204-pdnkabwj 278 4 correlation correlation NN cord-104204-pdnkabwj 278 5 has have VBZ cord-104204-pdnkabwj 278 6 also also RB cord-104204-pdnkabwj 278 7 been be VBN cord-104204-pdnkabwj 278 8 observed observe VBN cord-104204-pdnkabwj 278 9 between between IN cord-104204-pdnkabwj 278 10 cardiovascular cardiovascular JJ cord-104204-pdnkabwj 278 11 mortality mortality NN cord-104204-pdnkabwj 278 12 ( ( -LRB- cord-104204-pdnkabwj 278 13 CVM CVM NNP cord-104204-pdnkabwj 278 14 ) ) -RRB- cord-104204-pdnkabwj 278 15 rates rate NNS cord-104204-pdnkabwj 278 16 and and CC cord-104204-pdnkabwj 278 17 the the DT cord-104204-pdnkabwj 278 18 hardness hardness NN cord-104204-pdnkabwj 278 19 and and CC cord-104204-pdnkabwj 278 20 calcium calcium NN cord-104204-pdnkabwj 278 21 concentration concentration NN cord-104204-pdnkabwj 278 22 of of IN cord-104204-pdnkabwj 278 23 potable potable JJ cord-104204-pdnkabwj 278 24 ground ground NN cord-104204-pdnkabwj 278 25 water water NN cord-104204-pdnkabwj 278 26 . . . cord-104204-pdnkabwj 279 1 Apparendy Apparendy NNP cord-104204-pdnkabwj 279 2 , , , cord-104204-pdnkabwj 279 3 a a DT cord-104204-pdnkabwj 279 4 harder hard JJR cord-104204-pdnkabwj 279 5 water water NN cord-104204-pdnkabwj 279 6 and and CC cord-104204-pdnkabwj 279 7 a a DT cord-104204-pdnkabwj 279 8 higher high JJR cord-104204-pdnkabwj 279 9 concentration concentration NN cord-104204-pdnkabwj 279 10 of of IN cord-104204-pdnkabwj 279 11 dissolved dissolved JJ cord-104204-pdnkabwj 279 12 calcium calcium NN cord-104204-pdnkabwj 279 13 salts salt NNS cord-104204-pdnkabwj 279 14 ( ( -LRB- cord-104204-pdnkabwj 279 15 from from IN cord-104204-pdnkabwj 279 16 limestone limestone NN cord-104204-pdnkabwj 279 17 and and CC cord-104204-pdnkabwj 279 18 dolomite dolomite NN cord-104204-pdnkabwj 279 19 ) ) -RRB- cord-104204-pdnkabwj 279 20 are be VBP cord-104204-pdnkabwj 279 21 positively positively RB cord-104204-pdnkabwj 279 22 correlated correlate VBN cord-104204-pdnkabwj 279 23 with with IN cord-104204-pdnkabwj 279 24 increased increase VBN cord-104204-pdnkabwj 279 25 longevity longevity NN cord-104204-pdnkabwj 279 26 and and CC cord-104204-pdnkabwj 279 27 lower low JJR cord-104204-pdnkabwj 279 28 CVM CVM NNP cord-104204-pdnkabwj 279 29 in in IN cord-104204-pdnkabwj 279 30 the the DT cord-104204-pdnkabwj 279 31 northern northern JJ cord-104204-pdnkabwj 279 32 - - HYPH cord-104204-pdnkabwj 279 33 midcontinental midcontinental JJ cord-104204-pdnkabwj 279 34 United United NNP cord-104204-pdnkabwj 279 35 States States NNP cord-104204-pdnkabwj 279 36 , , , cord-104204-pdnkabwj 279 37 compared compare VBN cord-104204-pdnkabwj 279 38 to to IN cord-104204-pdnkabwj 279 39 decreased decrease VBN cord-104204-pdnkabwj 279 40 longevity longevity NN cord-104204-pdnkabwj 279 41 and and CC cord-104204-pdnkabwj 279 42 higher high JJR cord-104204-pdnkabwj 279 43 rates rate NNS cord-104204-pdnkabwj 279 44 of of IN cord-104204-pdnkabwj 279 45 cardiovascular cardiovascular JJ cord-104204-pdnkabwj 279 46 deaths death NNS cord-104204-pdnkabwj 279 47 in in IN cord-104204-pdnkabwj 279 48 the the DT cord-104204-pdnkabwj 279 49 southeastern southeastern JJ cord-104204-pdnkabwj 279 50 coastal coastal JJ cord-104204-pdnkabwj 279 51 area area NN cord-104204-pdnkabwj 279 52 where where WRB cord-104204-pdnkabwj 279 53 drinking drinking NN cord-104204-pdnkabwj 279 54 water water NN cord-104204-pdnkabwj 279 55 is be VBZ cord-104204-pdnkabwj 279 56 softer soft JJR cord-104204-pdnkabwj 279 57 and and CC cord-104204-pdnkabwj 279 58 Ca2 ca2 CD cord-104204-pdnkabwj 279 59 + + CC cord-104204-pdnkabwj 279 60 concentrations concentration NNS cord-104204-pdnkabwj 279 61 are be VBP cord-104204-pdnkabwj 279 62 lower low JJR cord-104204-pdnkabwj 279 63 ( ( -LRB- cord-104204-pdnkabwj 279 64 62 62 CD cord-104204-pdnkabwj 279 65 . . . cord-104204-pdnkabwj 280 1 The the DT cord-104204-pdnkabwj 280 2 etiology etiology NN cord-104204-pdnkabwj 280 3 of of IN cord-104204-pdnkabwj 280 4 CIN CIN NNP cord-104204-pdnkabwj 280 5 is be VBZ cord-104204-pdnkabwj 280 6 variously variously RB cord-104204-pdnkabwj 280 7 reported report VBN cord-104204-pdnkabwj 280 8 to to TO cord-104204-pdnkabwj 280 9 be be VB cord-104204-pdnkabwj 280 10 secondary secondary JJ cord-104204-pdnkabwj 280 11 to to IN cord-104204-pdnkabwj 280 12 metabolic metabolic JJ cord-104204-pdnkabwj 280 13 diseases disease NNS cord-104204-pdnkabwj 280 14 , , , cord-104204-pdnkabwj 280 15 drugs drug NNS cord-104204-pdnkabwj 280 16 ( ( -LRB- cord-104204-pdnkabwj 280 17 i.e. i.e. FW cord-104204-pdnkabwj 280 18 , , , cord-104204-pdnkabwj 280 19 analgesics analgesic NNS cord-104204-pdnkabwj 280 20 or or CC cord-104204-pdnkabwj 280 21 analgesic analgesic JJ cord-104204-pdnkabwj 280 22 mixtures mixture NNS cord-104204-pdnkabwj 280 23 ) ) -RRB- cord-104204-pdnkabwj 280 24 , , , cord-104204-pdnkabwj 280 25 or or CC cord-104204-pdnkabwj 280 26 known know VBN cord-104204-pdnkabwj 280 27 environmental environmental JJ cord-104204-pdnkabwj 280 28 factors factor NNS cord-104204-pdnkabwj 280 29 ( ( -LRB- cord-104204-pdnkabwj 280 30 e.g. e.g. RB cord-104204-pdnkabwj 280 31 , , , cord-104204-pdnkabwj 280 32 industrial industrial JJ cord-104204-pdnkabwj 280 33 pollution pollution NN cord-104204-pdnkabwj 280 34 with with IN cord-104204-pdnkabwj 280 35 lead lead NN cord-104204-pdnkabwj 280 36 , , , cord-104204-pdnkabwj 280 37 cadmium cadmium NN cord-104204-pdnkabwj 280 38 , , , cord-104204-pdnkabwj 280 39 mercury mercury NN cord-104204-pdnkabwj 280 40 , , , cord-104204-pdnkabwj 280 41 etc etc FW cord-104204-pdnkabwj 280 42 . . . cord-104204-pdnkabwj 280 43 ) ) -RRB- cord-104204-pdnkabwj 280 44 . . . cord-104204-pdnkabwj 281 1 About about RB cord-104204-pdnkabwj 281 2 15 15 CD cord-104204-pdnkabwj 281 3 - - SYM cord-104204-pdnkabwj 281 4 20 20 CD cord-104204-pdnkabwj 281 5 % % NN cord-104204-pdnkabwj 281 6 of of IN cord-104204-pdnkabwj 281 7 the the DT cord-104204-pdnkabwj 281 8 patients patient NNS cord-104204-pdnkabwj 281 9 in in IN cord-104204-pdnkabwj 281 10 end end NN cord-104204-pdnkabwj 281 11 stage stage NN cord-104204-pdnkabwj 281 12 renal renal JJ cord-104204-pdnkabwj 281 13 disease disease NN cord-104204-pdnkabwj 281 14 ( ( -LRB- cord-104204-pdnkabwj 281 15 ESRD ESRD NNP cord-104204-pdnkabwj 281 16 ) ) -RRB- cord-104204-pdnkabwj 281 17 treatment treatment NN cord-104204-pdnkabwj 281 18 centers center NNS cord-104204-pdnkabwj 281 19 who who WP cord-104204-pdnkabwj 281 20 have have VBP cord-104204-pdnkabwj 281 21 been be VBN cord-104204-pdnkabwj 281 22 diagnosed diagnose VBN cord-104204-pdnkabwj 281 23 with with IN cord-104204-pdnkabwj 281 24 CIN CIN NNP cord-104204-pdnkabwj 281 25 have have VBP cord-104204-pdnkabwj 281 26 no no DT cord-104204-pdnkabwj 281 27 established establish VBN cord-104204-pdnkabwj 281 28 etiology etiology NN cord-104204-pdnkabwj 281 29 . . . cord-104204-pdnkabwj 282 1 Without without IN cord-104204-pdnkabwj 282 2 a a DT cord-104204-pdnkabwj 282 3 known know VBN cord-104204-pdnkabwj 282 4 etiology etiology NN cord-104204-pdnkabwj 282 5 , , , cord-104204-pdnkabwj 282 6 prevention prevention NN cord-104204-pdnkabwj 282 7 of of IN cord-104204-pdnkabwj 282 8 disease disease NN cord-104204-pdnkabwj 282 9 is be VBZ cord-104204-pdnkabwj 282 10 an an DT cord-104204-pdnkabwj 282 11 elusive elusive JJ cord-104204-pdnkabwj 282 12 goal goal NN cord-104204-pdnkabwj 282 13 . . . cord-104204-pdnkabwj 283 1 Studies study NNS cord-104204-pdnkabwj 283 2 that that WDT cord-104204-pdnkabwj 283 3 will will MD cord-104204-pdnkabwj 283 4 yield yield VB cord-104204-pdnkabwj 283 5 information information NN cord-104204-pdnkabwj 283 6 on on IN cord-104204-pdnkabwj 283 7 the the DT cord-104204-pdnkabwj 283 8 causes cause NNS cord-104204-pdnkabwj 283 9 of of IN cord-104204-pdnkabwj 283 10 CIN CIN NNP cord-104204-pdnkabwj 283 11 could could MD cord-104204-pdnkabwj 283 12 have have VB cord-104204-pdnkabwj 283 13 an an DT cord-104204-pdnkabwj 283 14 obvious obvious JJ cord-104204-pdnkabwj 283 15 immediate immediate JJ cord-104204-pdnkabwj 283 16 prophylactic prophylactic JJ cord-104204-pdnkabwj 283 17 effect effect NN cord-104204-pdnkabwj 283 18 and and CC cord-104204-pdnkabwj 283 19 allow allow VB cord-104204-pdnkabwj 283 20 a a DT cord-104204-pdnkabwj 283 21 reduction reduction NN cord-104204-pdnkabwj 283 22 in in IN cord-104204-pdnkabwj 283 23 the the DT cord-104204-pdnkabwj 283 24 costs cost NNS cord-104204-pdnkabwj 283 25 of of IN cord-104204-pdnkabwj 283 26 kidney kidney NN cord-104204-pdnkabwj 283 27 transplantation transplantation NN cord-104204-pdnkabwj 283 28 and and CC cord-104204-pdnkabwj 283 29 dialysis dialysis NN cord-104204-pdnkabwj 283 30 , , , cord-104204-pdnkabwj 283 31 the the DT cord-104204-pdnkabwj 283 32 current current JJ cord-104204-pdnkabwj 283 33 final final JJ cord-104204-pdnkabwj 283 34 therapeutical therapeutical JJ cord-104204-pdnkabwj 283 35 solutions solution NNS cord-104204-pdnkabwj 283 36 for for IN cord-104204-pdnkabwj 283 37 ESRD ESRD NNP cord-104204-pdnkabwj 283 38 patients patient NNS cord-104204-pdnkabwj 283 39 . . . cord-104204-pdnkabwj 284 1 In in IN cord-104204-pdnkabwj 284 2 this this DT cord-104204-pdnkabwj 284 3 respect respect NN cord-104204-pdnkabwj 284 4 , , , cord-104204-pdnkabwj 284 5 identifying identify VBG cord-104204-pdnkabwj 284 6 the the DT cord-104204-pdnkabwj 284 7 factor(s factor(s NNP cord-104204-pdnkabwj 284 8 ) ) -RRB- cord-104204-pdnkabwj 284 9 responsible responsible JJ cord-104204-pdnkabwj 284 10 for for IN cord-104204-pdnkabwj 284 11 BEN BEN NNP cord-104204-pdnkabwj 284 12 will will MD cord-104204-pdnkabwj 284 13 lead lead VB cord-104204-pdnkabwj 284 14 to to IN cord-104204-pdnkabwj 284 15 a a DT cord-104204-pdnkabwj 284 16 deeper deep JJR cord-104204-pdnkabwj 284 17 understanding understanding NN cord-104204-pdnkabwj 284 18 of of IN cord-104204-pdnkabwj 284 19 the the DT cord-104204-pdnkabwj 284 20 etiopathogeny etiopathogeny NN cord-104204-pdnkabwj 284 21 of of IN cord-104204-pdnkabwj 284 22 this this DT cord-104204-pdnkabwj 284 23 disease disease NN cord-104204-pdnkabwj 284 24 and and CC cord-104204-pdnkabwj 284 25 to to IN cord-104204-pdnkabwj 284 26 a a DT cord-104204-pdnkabwj 284 27 better well JJR cord-104204-pdnkabwj 284 28 knowledge knowledge NN cord-104204-pdnkabwj 284 29 of of IN cord-104204-pdnkabwj 284 30 kidney kidney NN cord-104204-pdnkabwj 284 31 disease disease NN cord-104204-pdnkabwj 284 32 mechanisms mechanism NNS cord-104204-pdnkabwj 284 33 and and CC cord-104204-pdnkabwj 284 34 carcinogenesis carcinogenesis NN cord-104204-pdnkabwj 284 35 in in IN cord-104204-pdnkabwj 284 36 general general JJ cord-104204-pdnkabwj 284 37 . . . cord-104204-pdnkabwj 285 1 Unraveling unravel VBG cord-104204-pdnkabwj 285 2 the the DT cord-104204-pdnkabwj 285 3 etiology etiology NN cord-104204-pdnkabwj 285 4 of of IN cord-104204-pdnkabwj 285 5 BEN BEN NNP cord-104204-pdnkabwj 285 6 will will MD cord-104204-pdnkabwj 285 7 also also RB cord-104204-pdnkabwj 285 8 allow allow VB cord-104204-pdnkabwj 285 9 appropriate appropriate JJ cord-104204-pdnkabwj 285 10 preventive preventive JJ cord-104204-pdnkabwj 285 11 measures measure NNS cord-104204-pdnkabwj 285 12 to to TO cord-104204-pdnkabwj 285 13 be be VB cord-104204-pdnkabwj 285 14 taken take VBN cord-104204-pdnkabwj 285 15 in in IN cord-104204-pdnkabwj 285 16 the the DT cord-104204-pdnkabwj 285 17 afflicted afflict VBN cord-104204-pdnkabwj 285 18 areas area NNS cord-104204-pdnkabwj 285 19 , , , cord-104204-pdnkabwj 285 20 such such JJ cord-104204-pdnkabwj 285 21 as as IN cord-104204-pdnkabwj 285 22 by by IN cord-104204-pdnkabwj 285 23 treatment treatment NN cord-104204-pdnkabwj 285 24 or or CC cord-104204-pdnkabwj 285 25 filtration filtration NN cord-104204-pdnkabwj 285 26 of of IN cord-104204-pdnkabwj 285 27 the the DT cord-104204-pdnkabwj 285 28 drinking drinking NN cord-104204-pdnkabwj 285 29 and and CC cord-104204-pdnkabwj 285 30 cooking cooking NN cord-104204-pdnkabwj 285 31 water water NN cord-104204-pdnkabwj 285 32 or or CC cord-104204-pdnkabwj 285 33 changing change VBG cord-104204-pdnkabwj 285 34 the the DT cord-104204-pdnkabwj 285 35 main main JJ cord-104204-pdnkabwj 285 36 water water NN cord-104204-pdnkabwj 285 37 supply supply NN cord-104204-pdnkabwj 285 38 . . . cord-104204-pdnkabwj 286 1 Every every DT cord-104204-pdnkabwj 286 2 human human JJ cord-104204-pdnkabwj 286 3 disease disease NN cord-104204-pdnkabwj 286 4 has have VBZ cord-104204-pdnkabwj 286 5 a a DT cord-104204-pdnkabwj 286 6 multifactorial multifactorial JJ cord-104204-pdnkabwj 286 7 causality causality NN cord-104204-pdnkabwj 286 8 . . . cord-104204-pdnkabwj 287 1 Usually usually RB cord-104204-pdnkabwj 287 2 there there EX cord-104204-pdnkabwj 287 3 is be VBZ cord-104204-pdnkabwj 287 4 a a DT cord-104204-pdnkabwj 287 5 main main JJ cord-104204-pdnkabwj 287 6 factor factor NN cord-104204-pdnkabwj 287 7 whose whose WP$ cord-104204-pdnkabwj 287 8 sine sine FW cord-104204-pdnkabwj 287 9 qua qua FW cord-104204-pdnkabwj 287 10 non non JJ cord-104204-pdnkabwj 287 11 action action NN cord-104204-pdnkabwj 287 12 is be VBZ cord-104204-pdnkabwj 287 13 sufficient sufficient JJ cord-104204-pdnkabwj 287 14 for for IN cord-104204-pdnkabwj 287 15 triggering trigger VBG cord-104204-pdnkabwj 287 16 a a DT cord-104204-pdnkabwj 287 17 pathogenic pathogenic JJ cord-104204-pdnkabwj 287 18 process process NN cord-104204-pdnkabwj 287 19 that that WDT cord-104204-pdnkabwj 287 20 individualizes individualizes VBP cord-104204-pdnkabwj 287 21 the the DT cord-104204-pdnkabwj 287 22 disease disease NN cord-104204-pdnkabwj 287 23 . . . cord-104204-pdnkabwj 288 1 Other other JJ cord-104204-pdnkabwj 288 2 factors factor NNS cord-104204-pdnkabwj 288 3 without without IN cord-104204-pdnkabwj 288 4 direct direct JJ cord-104204-pdnkabwj 288 5 and and CC cord-104204-pdnkabwj 288 6 feasibly feasibly RB cord-104204-pdnkabwj 288 7 quantifiable quantifiable JJ cord-104204-pdnkabwj 288 8 effects effect NNS cord-104204-pdnkabwj 288 9 in in IN cord-104204-pdnkabwj 288 10 disease disease NN cord-104204-pdnkabwj 288 11 genesis genesis NN cord-104204-pdnkabwj 288 12 and and CC cord-104204-pdnkabwj 288 13 evolution evolution NN cord-104204-pdnkabwj 288 14 are be VBP cord-104204-pdnkabwj 288 15 frequently frequently RB cord-104204-pdnkabwj 288 16 neglected neglect VBN cord-104204-pdnkabwj 288 17 , , , cord-104204-pdnkabwj 288 18 although although IN cord-104204-pdnkabwj 288 19 in in IN cord-104204-pdnkabwj 288 20 their -PRON- PRP$ cord-104204-pdnkabwj 288 21 absence absence NN cord-104204-pdnkabwj 288 22 the the DT cord-104204-pdnkabwj 288 23 disease disease NN cord-104204-pdnkabwj 288 24 pattern pattern NN cord-104204-pdnkabwj 288 25 and and CC cord-104204-pdnkabwj 288 26 progression progression NN cord-104204-pdnkabwj 288 27 should should MD cord-104204-pdnkabwj 288 28 be be VB cord-104204-pdnkabwj 288 29 different different JJ cord-104204-pdnkabwj 288 30 . . . cord-104204-pdnkabwj 289 1 What what WP cord-104204-pdnkabwj 289 2 is be VBZ cord-104204-pdnkabwj 289 3 involved involve VBN cord-104204-pdnkabwj 289 4 and and CC cord-104204-pdnkabwj 289 5 what what WP cord-104204-pdnkabwj 289 6 is be VBZ cord-104204-pdnkabwj 289 7 not not RB cord-104204-pdnkabwj 289 8 in in IN cord-104204-pdnkabwj 289 9 BEN BEN NNP cord-104204-pdnkabwj 289 10 etiology etiology NN cord-104204-pdnkabwj 289 11 are be VBP cord-104204-pdnkabwj 289 12 questions question NNS cord-104204-pdnkabwj 289 13 equally equally RB cord-104204-pdnkabwj 289 14 difficult difficult JJ cord-104204-pdnkabwj 289 15 to to TO cord-104204-pdnkabwj 289 16 answer answer VB cord-104204-pdnkabwj 289 17 , , , cord-104204-pdnkabwj 289 18 and and CC cord-104204-pdnkabwj 289 19 some some DT cord-104204-pdnkabwj 289 20 of of IN cord-104204-pdnkabwj 289 21 the the DT cord-104204-pdnkabwj 289 22 reasons reason NNS cord-104204-pdnkabwj 289 23 for for IN cord-104204-pdnkabwj 289 24 this this DT cord-104204-pdnkabwj 289 25 are be VBP cord-104204-pdnkabwj 289 26 stated state VBN cord-104204-pdnkabwj 289 27 above above RB cord-104204-pdnkabwj 289 28 . . . cord-104204-pdnkabwj 290 1 Similar similar JJ cord-104204-pdnkabwj 290 2 problems problem NNS cord-104204-pdnkabwj 290 3 are be VBP cord-104204-pdnkabwj 290 4 evident evident JJ cord-104204-pdnkabwj 290 5 when when WRB cord-104204-pdnkabwj 290 6 the the DT cord-104204-pdnkabwj 290 7 long long JJ cord-104204-pdnkabwj 290 8 - - HYPH cord-104204-pdnkabwj 290 9 term term NN cord-104204-pdnkabwj 290 10 and and CC cord-104204-pdnkabwj 290 11 sometimes sometimes RB cord-104204-pdnkabwj 290 12 combined combine VBN cord-104204-pdnkabwj 290 13 effects effect NNS cord-104204-pdnkabwj 290 14 of of IN cord-104204-pdnkabwj 290 15 twentieth twentieth JJ cord-104204-pdnkabwj 290 16 century century NN cord-104204-pdnkabwj 290 17 environmental environmental JJ cord-104204-pdnkabwj 290 18 pollutants pollutant NNS cord-104204-pdnkabwj 290 19 , , , cord-104204-pdnkabwj 290 20 including include VBG cord-104204-pdnkabwj 290 21 pesticides pesticide NNS cord-104204-pdnkabwj 290 22 and and CC cord-104204-pdnkabwj 290 23 the the DT cord-104204-pdnkabwj 290 24 largely largely RB cord-104204-pdnkabwj 290 25 debated debate VBN cord-104204-pdnkabwj 290 26 endocrine endocrine JJ cord-104204-pdnkabwj 290 27 disruptors disruptor NNS cord-104204-pdnkabwj 290 28 , , , cord-104204-pdnkabwj 290 29 are be VBP cord-104204-pdnkabwj 290 30 assessed assess VBN cord-104204-pdnkabwj 290 31 and and CC cord-104204-pdnkabwj 290 32 straightforward straightforward JJ cord-104204-pdnkabwj 290 33 answers answer NNS cord-104204-pdnkabwj 290 34 are be VBP cord-104204-pdnkabwj 290 35 expected expect VBN cord-104204-pdnkabwj 290 36 . . . cord-104204-pdnkabwj 291 1 Due due IN cord-104204-pdnkabwj 291 2 to to IN cord-104204-pdnkabwj 291 3 the the DT cord-104204-pdnkabwj 291 4 synergistic synergistic JJ cord-104204-pdnkabwj 291 5 ( ( -LRB- cord-104204-pdnkabwj 291 6 or or CC cord-104204-pdnkabwj 291 7 antagonistic antagonistic JJ cord-104204-pdnkabwj 291 8 ) ) -RRB- cord-104204-pdnkabwj 291 9 and and CC cord-104204-pdnkabwj 291 10 not not RB cord-104204-pdnkabwj 291 11 infrequently infrequently RB cord-104204-pdnkabwj 291 12 transgenerational transgenerational JJ cord-104204-pdnkabwj 291 13 action action NN cord-104204-pdnkabwj 291 14 of of IN cord-104204-pdnkabwj 291 15 a a DT cord-104204-pdnkabwj 291 16 multitude multitude NN cord-104204-pdnkabwj 291 17 of of IN cord-104204-pdnkabwj 291 18 factors factor NNS cord-104204-pdnkabwj 291 19 ( ( -LRB- cord-104204-pdnkabwj 291 20 some some DT cord-104204-pdnkabwj 291 21 even even RB cord-104204-pdnkabwj 291 22 unimagined unimagined JJ cord-104204-pdnkabwj 291 23 ) ) -RRB- cord-104204-pdnkabwj 291 24 , , , cord-104204-pdnkabwj 291 25 a a DT cord-104204-pdnkabwj 291 26 cause cause NN cord-104204-pdnkabwj 291 27 - - HYPH cord-104204-pdnkabwj 291 28 effect effect NN cord-104204-pdnkabwj 291 29 relationship relationship NN cord-104204-pdnkabwj 291 30 is be VBZ cord-104204-pdnkabwj 291 31 not not RB cord-104204-pdnkabwj 291 32 always always RB cord-104204-pdnkabwj 291 33 obvious obvious JJ cord-104204-pdnkabwj 291 34 . . . cord-104204-pdnkabwj 292 1 Causative causative JJ cord-104204-pdnkabwj 292 2 agents agent NNS cord-104204-pdnkabwj 292 3 interplay interplay VBP cord-104204-pdnkabwj 292 4 with with IN cord-104204-pdnkabwj 292 5 predisposing predisposing JJ cord-104204-pdnkabwj 292 6 or or CC cord-104204-pdnkabwj 292 7 constitutional constitutional JJ cord-104204-pdnkabwj 292 8 factors factor NNS cord-104204-pdnkabwj 292 9 ( ( -LRB- cord-104204-pdnkabwj 292 10 cofactors cofactor NNS cord-104204-pdnkabwj 292 11 or or CC cord-104204-pdnkabwj 292 12 risk risk NN cord-104204-pdnkabwj 292 13 factors factor NNS cord-104204-pdnkabwj 292 14 ) ) -RRB- cord-104204-pdnkabwj 292 15 toward toward IN cord-104204-pdnkabwj 292 16 a a DT cord-104204-pdnkabwj 292 17 complex complex JJ cord-104204-pdnkabwj 292 18 disease disease NN cord-104204-pdnkabwj 292 19 phenotype phenotype NN cord-104204-pdnkabwj 292 20 . . . cord-104204-pdnkabwj 293 1 Defined define VBN cord-104204-pdnkabwj 293 2 initially initially RB cord-104204-pdnkabwj 293 3 as as IN cord-104204-pdnkabwj 293 4 a a DT cord-104204-pdnkabwj 293 5 lead lead JJ cord-104204-pdnkabwj 293 6 nephropathy nephropathy NN cord-104204-pdnkabwj 293 7 , , , cord-104204-pdnkabwj 293 8 subsequently subsequently RB cord-104204-pdnkabwj 293 9 considered consider VBD cord-104204-pdnkabwj 293 10 a a DT cord-104204-pdnkabwj 293 11 viral viral JJ cord-104204-pdnkabwj 293 12 disease disease NN cord-104204-pdnkabwj 293 13 , , , cord-104204-pdnkabwj 293 14 a a DT cord-104204-pdnkabwj 293 15 genetic genetic JJ cord-104204-pdnkabwj 293 16 or or CC cord-104204-pdnkabwj 293 17 chromosomal chromosomal JJ cord-104204-pdnkabwj 293 18 disorder disorder NN cord-104204-pdnkabwj 293 19 , , , cord-104204-pdnkabwj 293 20 or or CC cord-104204-pdnkabwj 293 21 a a DT cord-104204-pdnkabwj 293 22 form form NN cord-104204-pdnkabwj 293 23 of of IN cord-104204-pdnkabwj 293 24 chronic chronic JJ cord-104204-pdnkabwj 293 25 pyelonephritis pyelonephritis NN cord-104204-pdnkabwj 293 26 , , , cord-104204-pdnkabwj 293 27 BEN BEN NNP cord-104204-pdnkabwj 293 28 is be VBZ cord-104204-pdnkabwj 293 29 presently presently RB cord-104204-pdnkabwj 293 30 thought think VBN cord-104204-pdnkabwj 293 31 of of IN cord-104204-pdnkabwj 293 32 by by IN cord-104204-pdnkabwj 293 33 most most JJS cord-104204-pdnkabwj 293 34 researchers researcher NNS cord-104204-pdnkabwj 293 35 as as IN cord-104204-pdnkabwj 293 36 an an DT cord-104204-pdnkabwj 293 37 environmental environmental JJ cord-104204-pdnkabwj 293 38 disease disease NN cord-104204-pdnkabwj 293 39 . . . cord-104204-pdnkabwj 294 1 Although although IN cord-104204-pdnkabwj 294 2 the the DT cord-104204-pdnkabwj 294 3 environmental environmental JJ cord-104204-pdnkabwj 294 4 etiology etiology NN cord-104204-pdnkabwj 294 5 is be VBZ cord-104204-pdnkabwj 294 6 widely widely RB cord-104204-pdnkabwj 294 7 accepted accept VBN cord-104204-pdnkabwj 294 8 , , , cord-104204-pdnkabwj 294 9 the the DT cord-104204-pdnkabwj 294 10 true true JJ cord-104204-pdnkabwj 294 11 factor(s factor(s NNP cord-104204-pdnkabwj 294 12 ) ) -RRB- cord-104204-pdnkabwj 294 13 causing cause VBG cord-104204-pdnkabwj 294 14 the the DT cord-104204-pdnkabwj 294 15 disease disease NN cord-104204-pdnkabwj 294 16 is be VBZ cord-104204-pdnkabwj 294 17 unclear unclear JJ cord-104204-pdnkabwj 294 18 . . . cord-104204-pdnkabwj 295 1 Multidisciplinary multidisciplinary JJ cord-104204-pdnkabwj 295 2 approaches approach NNS cord-104204-pdnkabwj 295 3 carried carry VBN cord-104204-pdnkabwj 295 4 on on RP cord-104204-pdnkabwj 295 5 in in IN cord-104204-pdnkabwj 295 6 various various JJ cord-104204-pdnkabwj 295 7 countries country NNS cord-104204-pdnkabwj 295 8 have have VBP cord-104204-pdnkabwj 295 9 excluded exclude VBN cord-104204-pdnkabwj 295 10 some some DT cord-104204-pdnkabwj 295 11 of of IN cord-104204-pdnkabwj 295 12 the the DT cord-104204-pdnkabwj 295 13 factors factor NNS cord-104204-pdnkabwj 295 14 claimed claim VBD cord-104204-pdnkabwj 295 15 to to TO cord-104204-pdnkabwj 295 16 cause cause VB cord-104204-pdnkabwj 295 17 BEN BEN NNP cord-104204-pdnkabwj 295 18 . . . cord-104204-pdnkabwj 296 1 These these DT cord-104204-pdnkabwj 296 2 studies study NNS cord-104204-pdnkabwj 296 3 , , , cord-104204-pdnkabwj 296 4 however however RB cord-104204-pdnkabwj 296 5 , , , cord-104204-pdnkabwj 296 6 have have VBP cord-104204-pdnkabwj 296 7 also also RB cord-104204-pdnkabwj 296 8 outlined outline VBN cord-104204-pdnkabwj 296 9 some some DT cord-104204-pdnkabwj 296 10 factors factor NNS cord-104204-pdnkabwj 296 11 that that WDT cord-104204-pdnkabwj 296 12 can can MD cord-104204-pdnkabwj 296 13 not not RB cord-104204-pdnkabwj 296 14 be be VB cord-104204-pdnkabwj 296 15 disregarded disregard VBN cord-104204-pdnkabwj 296 16 when when WRB cord-104204-pdnkabwj 296 17 considering consider VBG cord-104204-pdnkabwj 296 18 BEN BEN NNP cord-104204-pdnkabwj 296 19 etiopathogeny etiopathogeny NNP cord-104204-pdnkabwj 296 20 , , , cord-104204-pdnkabwj 296 21 as as IN cord-104204-pdnkabwj 296 22 they -PRON- PRP cord-104204-pdnkabwj 296 23 can can MD cord-104204-pdnkabwj 296 24 comfortably comfortably RB cord-104204-pdnkabwj 296 25 explain explain VB cord-104204-pdnkabwj 296 26 certain certain JJ cord-104204-pdnkabwj 296 27 features feature NNS cord-104204-pdnkabwj 296 28 of of IN cord-104204-pdnkabwj 296 29 the the DT cord-104204-pdnkabwj 296 30 disease disease NN cord-104204-pdnkabwj 296 31 ( ( -LRB- cord-104204-pdnkabwj 296 32 e.g. e.g. RB cord-104204-pdnkabwj 296 33 , , , cord-104204-pdnkabwj 296 34 familial familial JJ cord-104204-pdnkabwj 296 35 aggregation aggregation NN cord-104204-pdnkabwj 296 36 , , , cord-104204-pdnkabwj 296 37 geographic geographic JJ cord-104204-pdnkabwj 296 38 confinement confinement NN cord-104204-pdnkabwj 296 39 , , , cord-104204-pdnkabwj 296 40 association association NN cord-104204-pdnkabwj 296 41 with with IN cord-104204-pdnkabwj 296 42 uroepithelial uroepithelial JJ cord-104204-pdnkabwj 296 43 tumors tumor NNS cord-104204-pdnkabwj 296 44 , , , cord-104204-pdnkabwj 296 45 etc etc FW cord-104204-pdnkabwj 296 46 . . . cord-104204-pdnkabwj 296 47 ) ) -RRB- cord-104204-pdnkabwj 296 48 . . . cord-104204-pdnkabwj 297 1 BEN BEN NNP cord-104204-pdnkabwj 297 2 , , , cord-104204-pdnkabwj 297 3 from from IN cord-104204-pdnkabwj 297 4 these these DT cord-104204-pdnkabwj 297 5 standpoints standpoint NNS cord-104204-pdnkabwj 297 6 , , , cord-104204-pdnkabwj 297 7 may may MD cord-104204-pdnkabwj 297 8 offer offer VB cord-104204-pdnkabwj 297 9 a a DT cord-104204-pdnkabwj 297 10 conceptual conceptual JJ cord-104204-pdnkabwj 297 11 and and CC cord-104204-pdnkabwj 297 12 mechanistical mechanistical JJ cord-104204-pdnkabwj 297 13 model model NN cord-104204-pdnkabwj 297 14 for for IN cord-104204-pdnkabwj 297 15 the the DT cord-104204-pdnkabwj 297 16 complex complex JJ cord-104204-pdnkabwj 297 17 and and CC cord-104204-pdnkabwj 297 18 integrated integrated JJ cord-104204-pdnkabwj 297 19 topics topic NNS cord-104204-pdnkabwj 297 20 pertinent pertinent JJ cord-104204-pdnkabwj 297 21 to to IN cord-104204-pdnkabwj 297 22 the the DT cord-104204-pdnkabwj 297 23 study study NN cord-104204-pdnkabwj 297 24 of of IN cord-104204-pdnkabwj 297 25 environmental environmental JJ cord-104204-pdnkabwj 297 26 diseases disease NNS cord-104204-pdnkabwj 297 27 . . . cord-104204-pdnkabwj 298 1 Epidemiology epidemiology NN cord-104204-pdnkabwj 298 2 of of IN cord-104204-pdnkabwj 298 3 Balkan balkan JJ cord-104204-pdnkabwj 298 4 endemic endemic JJ cord-104204-pdnkabwj 298 5 nephropathy nephropathy NN cord-104204-pdnkabwj 298 6 On on IN cord-104204-pdnkabwj 298 7 Danubian danubian JJ cord-104204-pdnkabwj 298 8 endemic endemic JJ cord-104204-pdnkabwj 298 9 familial familial JJ cord-104204-pdnkabwj 298 10 nephropathy nephropathy NN cord-104204-pdnkabwj 298 11 ( ( -LRB- cord-104204-pdnkabwj 298 12 Balkan balkan JJ cord-104204-pdnkabwj 298 13 nephropathy nephropathy NN cord-104204-pdnkabwj 298 14 ) ) -RRB- cord-104204-pdnkabwj 299 1 Some some DT cord-104204-pdnkabwj 299 2 features feature NNS cord-104204-pdnkabwj 299 3 of of IN cord-104204-pdnkabwj 299 4 Balkan balkan JJ cord-104204-pdnkabwj 299 5 endemic endemic JJ cord-104204-pdnkabwj 299 6 nephropathy nephropathy NN cord-104204-pdnkabwj 299 7 Balkan balkan JJ cord-104204-pdnkabwj 299 8 turmoil turmoil NN cord-104204-pdnkabwj 299 9 delays delay VBZ cord-104204-pdnkabwj 299 10 BEN BEN NNP cord-104204-pdnkabwj 299 11 research research NN cord-104204-pdnkabwj 299 12 : : : cord-104204-pdnkabwj 299 13 disease disease NN cord-104204-pdnkabwj 299 14 links link NNS cord-104204-pdnkabwj 299 15 to to IN cord-104204-pdnkabwj 299 16 weathered weather VBN cord-104204-pdnkabwj 299 17 low low JJ cord-104204-pdnkabwj 299 18 - - HYPH cord-104204-pdnkabwj 299 19 rank rank NN cord-104204-pdnkabwj 299 20 coals coal NNS cord-104204-pdnkabwj 299 21 remain remain VBP cord-104204-pdnkabwj 299 22 speculative speculative JJ cord-104204-pdnkabwj 299 23 Epidemiological epidemiological JJ cord-104204-pdnkabwj 299 24 characteristics characteristic NNS cord-104204-pdnkabwj 299 25 of of IN cord-104204-pdnkabwj 299 26 Balkan balkan JJ cord-104204-pdnkabwj 299 27 endemic endemic JJ cord-104204-pdnkabwj 299 28 nephropathy nephropathy NN cord-104204-pdnkabwj 299 29 in in IN cord-104204-pdnkabwj 299 30 eastern eastern JJ cord-104204-pdnkabwj 299 31 regions region NNS cord-104204-pdnkabwj 299 32 of of IN cord-104204-pdnkabwj 299 33 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 299 34 Health Health NNP cord-104204-pdnkabwj 299 35 center center NN cord-104204-pdnkabwj 299 36 control control NN cord-104204-pdnkabwj 299 37 of of IN cord-104204-pdnkabwj 299 38 patients patient NNS cord-104204-pdnkabwj 299 39 suffering suffer VBG cord-104204-pdnkabwj 299 40 from from IN cord-104204-pdnkabwj 299 41 endemic endemic JJ cord-104204-pdnkabwj 299 42 nephropathy nephropathy NN cord-104204-pdnkabwj 299 43 in in IN cord-104204-pdnkabwj 299 44 Vratza Vratza NNP cord-104204-pdnkabwj 299 45 District District NNP cord-104204-pdnkabwj 299 46 Chronic Chronic NNP cord-104204-pdnkabwj 299 47 nephritis nephritis NN cord-104204-pdnkabwj 299 48 caused cause VBN cord-104204-pdnkabwj 299 49 by by IN cord-104204-pdnkabwj 299 50 poisoning poisoning NN cord-104204-pdnkabwj 299 51 with with IN cord-104204-pdnkabwj 299 52 lead lead NN cord-104204-pdnkabwj 299 53 via via IN cord-104204-pdnkabwj 299 54 the the DT cord-104204-pdnkabwj 299 55 digestive digestive JJ cord-104204-pdnkabwj 299 56 tract tract NN cord-104204-pdnkabwj 299 57 ( ( -LRB- cord-104204-pdnkabwj 299 58 flour flour NN cord-104204-pdnkabwj 299 59 ) ) -RRB- cord-104204-pdnkabwj 300 1 Nefrita Nefrita NNP cord-104204-pdnkabwj 300 2 cronica cronica NNP cord-104204-pdnkabwj 300 3 azotemica azotemica NNP cord-104204-pdnkabwj 301 1 endo endo NN cord-104204-pdnkabwj 301 2 - - HYPH cord-104204-pdnkabwj 301 3 epidemica epidemica JJ cord-104204-pdnkabwj 301 4 Balkan balkan JJ cord-104204-pdnkabwj 301 5 endemic endemic JJ cord-104204-pdnkabwj 301 6 nephropathy nephropathy NN cord-104204-pdnkabwj 301 7 : : : cord-104204-pdnkabwj 301 8 more more JJR cord-104204-pdnkabwj 301 9 questions question NNS cord-104204-pdnkabwj 301 10 than than IN cord-104204-pdnkabwj 301 11 answers answer NNS cord-104204-pdnkabwj 301 12 Clinical clinical JJ cord-104204-pdnkabwj 301 13 features feature NNS cord-104204-pdnkabwj 301 14 of of IN cord-104204-pdnkabwj 301 15 Balkan balkan JJ cord-104204-pdnkabwj 301 16 endemic endemic JJ cord-104204-pdnkabwj 301 17 nephropathy nephropathy NN cord-104204-pdnkabwj 301 18 Endemic endemic JJ cord-104204-pdnkabwj 301 19 nephropathy nephropathy NN cord-104204-pdnkabwj 301 20 in in IN cord-104204-pdnkabwj 301 21 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 301 22 Hematological Hematological NNP cord-104204-pdnkabwj 301 23 changes change NNS cord-104204-pdnkabwj 301 24 in in IN cord-104204-pdnkabwj 301 25 endemic endemic JJ cord-104204-pdnkabwj 301 26 nephropathy nephropathy NN cord-104204-pdnkabwj 301 27 in in IN cord-104204-pdnkabwj 301 28 south south JJ cord-104204-pdnkabwj 301 29 - - HYPH cord-104204-pdnkabwj 301 30 east east NN cord-104204-pdnkabwj 301 31 Europe Europe NNP cord-104204-pdnkabwj 301 32 Identification Identification NNP cord-104204-pdnkabwj 301 33 of of IN cord-104204-pdnkabwj 301 34 a a DT cord-104204-pdnkabwj 301 35 novel novel NN cord-104204-pdnkabwj 301 36 subset subset NN cord-104204-pdnkabwj 301 37 of of IN cord-104204-pdnkabwj 301 38 T T NNP cord-104204-pdnkabwj 301 39 lymphocytes lymphocyte NNS cord-104204-pdnkabwj 301 40 in in IN cord-104204-pdnkabwj 301 41 patients patient NNS cord-104204-pdnkabwj 301 42 with with IN cord-104204-pdnkabwj 301 43 Balkanic Balkanic NNP cord-104204-pdnkabwj 301 44 nephropathy nephropathy NN cord-104204-pdnkabwj 301 45 Balkan balkan JJ cord-104204-pdnkabwj 301 46 endemic endemic JJ cord-104204-pdnkabwj 301 47 nephropathy nephropathy NN cord-104204-pdnkabwj 301 48 , , , cord-104204-pdnkabwj 301 49 the the DT cord-104204-pdnkabwj 301 50 hematopoietic hematopoietic JJ cord-104204-pdnkabwj 301 51 system system NN cord-104204-pdnkabwj 301 52 and and CC cord-104204-pdnkabwj 301 53 the the DT cord-104204-pdnkabwj 301 54 environmental environmental JJ cord-104204-pdnkabwj 301 55 connection connection NN cord-104204-pdnkabwj 301 56 Cytokine cytokine NN cord-104204-pdnkabwj 301 57 levels level NNS cord-104204-pdnkabwj 301 58 in in IN cord-104204-pdnkabwj 301 59 patients patient NNS cord-104204-pdnkabwj 301 60 with with IN cord-104204-pdnkabwj 301 61 Balkan balkan JJ cord-104204-pdnkabwj 301 62 nephropathy nephropathy NN cord-104204-pdnkabwj 302 1 Some some DT cord-104204-pdnkabwj 302 2 pathomorphological pathomorphological JJ cord-104204-pdnkabwj 302 3 features feature NNS cord-104204-pdnkabwj 302 4 of of IN cord-104204-pdnkabwj 302 5 Balkan balkan JJ cord-104204-pdnkabwj 302 6 endemic endemic JJ cord-104204-pdnkabwj 302 7 nephropathy nephropathy NN cord-104204-pdnkabwj 302 8 in in IN cord-104204-pdnkabwj 302 9 Croatia Croatia NNP cord-104204-pdnkabwj 302 10 Eastern Eastern NNP cord-104204-pdnkabwj 302 11 Europe Europe NNP cord-104204-pdnkabwj 302 12 : : : cord-104204-pdnkabwj 302 13 missing miss VBG cord-104204-pdnkabwj 302 14 an an DT cord-104204-pdnkabwj 302 15 opportunity opportunity NN cord-104204-pdnkabwj 302 16 Viruses virus NNS cord-104204-pdnkabwj 302 17 in in IN cord-104204-pdnkabwj 302 18 endemic endemic JJ cord-104204-pdnkabwj 302 19 ( ( -LRB- cord-104204-pdnkabwj 302 20 Balkan balkan JJ cord-104204-pdnkabwj 302 21 ) ) -RRB- cord-104204-pdnkabwj 302 22 nephropathy nephropathy NN cord-104204-pdnkabwj 302 23 Evidence evidence NN cord-104204-pdnkabwj 302 24 of of IN cord-104204-pdnkabwj 302 25 a a DT cord-104204-pdnkabwj 302 26 viral viral JJ cord-104204-pdnkabwj 302 27 etiology etiology NN cord-104204-pdnkabwj 302 28 in in IN cord-104204-pdnkabwj 302 29 endemic endemic JJ cord-104204-pdnkabwj 302 30 ( ( -LRB- cord-104204-pdnkabwj 302 31 Balkan balkan JJ cord-104204-pdnkabwj 302 32 ) ) -RRB- cord-104204-pdnkabwj 302 33 nephropathy nephropathy NN cord-104204-pdnkabwj 302 34 Cytogenetic Cytogenetic NNP cord-104204-pdnkabwj 302 35 studies study NNS cord-104204-pdnkabwj 302 36 in in IN cord-104204-pdnkabwj 302 37 Balkan balkan JJ cord-104204-pdnkabwj 302 38 endemic endemic JJ cord-104204-pdnkabwj 302 39 nephropathy nephropathy NN cord-104204-pdnkabwj 302 40 Genetic genetic JJ cord-104204-pdnkabwj 302 41 predisposition predisposition NN cord-104204-pdnkabwj 302 42 to to IN cord-104204-pdnkabwj 302 43 Balkan balkan JJ cord-104204-pdnkabwj 302 44 endemic endemic JJ cord-104204-pdnkabwj 302 45 nephropathy nephropathy NN cord-104204-pdnkabwj 302 46 Environmental environmental JJ cord-104204-pdnkabwj 302 47 renal renal JJ cord-104204-pdnkabwj 302 48 disease disease NN cord-104204-pdnkabwj 302 49 : : : cord-104204-pdnkabwj 302 50 lead lead NN cord-104204-pdnkabwj 302 51 , , , cord-104204-pdnkabwj 302 52 cadmium cadmium NN cord-104204-pdnkabwj 302 53 and and CC cord-104204-pdnkabwj 302 54 Balkan balkan JJ cord-104204-pdnkabwj 302 55 endemic endemic JJ cord-104204-pdnkabwj 302 56 nephropathy nephropathy NN cord-104204-pdnkabwj 302 57 Selenium Selenium NNP cord-104204-pdnkabwj 302 58 deficiency deficiency NN cord-104204-pdnkabwj 302 59 in in IN cord-104204-pdnkabwj 302 60 Yugoslavia Yugoslavia NNP cord-104204-pdnkabwj 302 61 Djujic Djujic NNP cord-104204-pdnkabwj 302 62 1 1 CD cord-104204-pdnkabwj 302 63 . . . cord-104204-pdnkabwj 303 1 Selenium selenium NN cord-104204-pdnkabwj 303 2 deficiency deficiency NN cord-104204-pdnkabwj 303 3 in in IN cord-104204-pdnkabwj 303 4 Serbia Serbia NNP cord-104204-pdnkabwj 303 5 and and CC cord-104204-pdnkabwj 303 6 possible possible JJ cord-104204-pdnkabwj 303 7 effects effect NNS cord-104204-pdnkabwj 303 8 on on IN cord-104204-pdnkabwj 303 9 health health NN cord-104204-pdnkabwj 303 10 Possible possible JJ cord-104204-pdnkabwj 303 11 pathogenic pathogenic JJ cord-104204-pdnkabwj 303 12 role role NN cord-104204-pdnkabwj 303 13 of of IN cord-104204-pdnkabwj 303 14 low low JJ cord-104204-pdnkabwj 303 15 - - HYPH cord-104204-pdnkabwj 303 16 molecular molecular JJ cord-104204-pdnkabwj 303 17 - - HYPH cord-104204-pdnkabwj 303 18 weight weight NN cord-104204-pdnkabwj 303 19 proteins protein NNS cord-104204-pdnkabwj 303 20 in in IN cord-104204-pdnkabwj 303 21 Balkan balkan JJ cord-104204-pdnkabwj 303 22 nephropathy nephropathy NN cord-104204-pdnkabwj 303 23 Selenium selenium NN cord-104204-pdnkabwj 303 24 : : : cord-104204-pdnkabwj 303 25 mechanistic mechanistic JJ cord-104204-pdnkabwj 303 26 aspects aspect NNS cord-104204-pdnkabwj 303 27 of of IN cord-104204-pdnkabwj 303 28 anticarcinogenic anticarcinogenic NNP cord-104204-pdnkabwj 303 29 action action NN cord-104204-pdnkabwj 304 1 Understanding understand VBG cord-104204-pdnkabwj 304 2 gene gene NN cord-104204-pdnkabwj 304 3 - - HYPH cord-104204-pdnkabwj 304 4 environment environment NN cord-104204-pdnkabwj 304 5 interactions interaction NNS cord-104204-pdnkabwj 304 6 Relationship relationship NN cord-104204-pdnkabwj 304 7 between between IN cord-104204-pdnkabwj 304 8 weathered weathered JJ cord-104204-pdnkabwj 304 9 coal coal NN cord-104204-pdnkabwj 304 10 deposits deposit NNS cord-104204-pdnkabwj 304 11 and and CC cord-104204-pdnkabwj 304 12 the the DT cord-104204-pdnkabwj 304 13 etiology etiology NN cord-104204-pdnkabwj 304 14 of of IN cord-104204-pdnkabwj 304 15 Balkan balkan JJ cord-104204-pdnkabwj 304 16 endemic endemic JJ cord-104204-pdnkabwj 304 17 nephropathy nephropathy NN cord-104204-pdnkabwj 304 18 Mycotoxic Mycotoxic NNP cord-104204-pdnkabwj 304 19 porcine porcine JJ cord-104204-pdnkabwj 304 20 nephropathy nephropathy NN cord-104204-pdnkabwj 304 21 : : : cord-104204-pdnkabwj 305 1 a a DT cord-104204-pdnkabwj 305 2 possible possible JJ cord-104204-pdnkabwj 305 3 model model NN cord-104204-pdnkabwj 305 4 for for IN cord-104204-pdnkabwj 305 5 Balkan balkan JJ cord-104204-pdnkabwj 305 6 endemic endemic JJ cord-104204-pdnkabwj 305 7 nephropathy nephropathy NN cord-104204-pdnkabwj 305 8 Ochratoxins Ochratoxins NNP cord-104204-pdnkabwj 305 9 in in IN cord-104204-pdnkabwj 305 10 food food NN cord-104204-pdnkabwj 305 11 Role role NN cord-104204-pdnkabwj 305 12 of of IN cord-104204-pdnkabwj 305 13 ochratoxin ochratoxin NN cord-104204-pdnkabwj 305 14 in in IN cord-104204-pdnkabwj 305 15 disease disease NN cord-104204-pdnkabwj 305 16 causation causation NN cord-104204-pdnkabwj 305 17 Is be VBZ cord-104204-pdnkabwj 305 18 ochratoxin ochratoxin NN cord-104204-pdnkabwj 306 1 A a DT cord-104204-pdnkabwj 306 2 a a DT cord-104204-pdnkabwj 306 3 nephrotoxic nephrotoxic NN cord-104204-pdnkabwj 306 4 in in IN cord-104204-pdnkabwj 306 5 human human JJ cord-104204-pdnkabwj 306 6 beings being NNS cord-104204-pdnkabwj 306 7 ? ? . cord-104204-pdnkabwj 307 1 The the DT cord-104204-pdnkabwj 307 2 toxicology toxicology NN cord-104204-pdnkabwj 307 3 of of IN cord-104204-pdnkabwj 307 4 mycotoxins mycotoxin NNS cord-104204-pdnkabwj 307 5 Molecular molecular JJ cord-104204-pdnkabwj 307 6 and and CC cord-104204-pdnkabwj 307 7 epidemiological epidemiological JJ cord-104204-pdnkabwj 307 8 approaches approach NNS cord-104204-pdnkabwj 307 9 to to IN cord-104204-pdnkabwj 307 10 the the DT cord-104204-pdnkabwj 307 11 etiology etiology NN cord-104204-pdnkabwj 307 12 of of IN cord-104204-pdnkabwj 307 13 urinary urinary JJ cord-104204-pdnkabwj 307 14 tract tract JJ cord-104204-pdnkabwj 307 15 tumors tumor NNS cord-104204-pdnkabwj 307 16 in in IN cord-104204-pdnkabwj 307 17 an an DT cord-104204-pdnkabwj 307 18 area area NN cord-104204-pdnkabwj 307 19 with with IN cord-104204-pdnkabwj 307 20 Balkan balkan JJ cord-104204-pdnkabwj 307 21 endemic endemic JJ cord-104204-pdnkabwj 307 22 nephropathy nephropathy NN cord-104204-pdnkabwj 307 23 Ochratoxin Ochratoxin NNP cord-104204-pdnkabwj 307 24 A A NNP cord-104204-pdnkabwj 307 25 in in IN cord-104204-pdnkabwj 307 26 human human JJ cord-104204-pdnkabwj 307 27 sera sera NNP cord-104204-pdnkabwj 307 28 in in IN cord-104204-pdnkabwj 307 29 the the DT cord-104204-pdnkabwj 307 30 area area NN cord-104204-pdnkabwj 307 31 with with IN cord-104204-pdnkabwj 307 32 endemic endemic JJ cord-104204-pdnkabwj 307 33 nephropathy nephropathy NN cord-104204-pdnkabwj 307 34 in in IN cord-104204-pdnkabwj 307 35 Croatia Croatia NNP cord-104204-pdnkabwj 307 36 Foodstuffs Foodstuffs NNPS cord-104204-pdnkabwj 307 37 and and CC cord-104204-pdnkabwj 307 38 human human JJ cord-104204-pdnkabwj 307 39 blood blood NN cord-104204-pdnkabwj 307 40 contamination contamination NN cord-104204-pdnkabwj 307 41 by by IN cord-104204-pdnkabwj 307 42 the the DT cord-104204-pdnkabwj 307 43 mycotoxin mycotoxin NN cord-104204-pdnkabwj 307 44 ochratoxin ochratoxin NN cord-104204-pdnkabwj 307 45 A a NN cord-104204-pdnkabwj 307 46 : : : cord-104204-pdnkabwj 307 47 correlation correlation NN cord-104204-pdnkabwj 307 48 with with IN cord-104204-pdnkabwj 307 49 chronic chronic JJ cord-104204-pdnkabwj 307 50 interstitial interstitial JJ cord-104204-pdnkabwj 307 51 nephropathy nephropathy NN cord-104204-pdnkabwj 307 52 in in IN cord-104204-pdnkabwj 307 53 Tunisia Tunisia NNP cord-104204-pdnkabwj 307 54 Ochratoxin Ochratoxin NNP cord-104204-pdnkabwj 307 55 A A NNP cord-104204-pdnkabwj 307 56 in in IN cord-104204-pdnkabwj 307 57 human human JJ cord-104204-pdnkabwj 307 58 blood blood NN cord-104204-pdnkabwj 307 59 in in IN cord-104204-pdnkabwj 307 60 relation relation NN cord-104204-pdnkabwj 307 61 to to IN cord-104204-pdnkabwj 307 62 nephropathy nephropathy NN cord-104204-pdnkabwj 307 63 in in IN cord-104204-pdnkabwj 307 64 Tunisia Tunisia NNP cord-104204-pdnkabwj 307 65 Kidney Kidney NNP cord-104204-pdnkabwj 307 66 disease disease NN cord-104204-pdnkabwj 307 67 beyond beyond IN cord-104204-pdnkabwj 307 68 the the DT cord-104204-pdnkabwj 307 69 Balkans Balkans NNPS cord-104204-pdnkabwj 307 70 ? ? . cord-104204-pdnkabwj 308 1 Correlation correlation NN cord-104204-pdnkabwj 308 2 of of IN cord-104204-pdnkabwj 308 3 Balkan balkan JJ cord-104204-pdnkabwj 308 4 endemic endemic JJ cord-104204-pdnkabwj 308 5 nephropathy nephropathy NN cord-104204-pdnkabwj 308 6 with with IN cord-104204-pdnkabwj 308 7 fluorescent fluorescent JJ cord-104204-pdnkabwj 308 8 organic organic JJ cord-104204-pdnkabwj 308 9 compounds compound NNS cord-104204-pdnkabwj 308 10 in in IN cord-104204-pdnkabwj 308 11 shallow shallow JJ cord-104204-pdnkabwj 308 12 ground ground NN cord-104204-pdnkabwj 308 13 water water NN cord-104204-pdnkabwj 308 14 Relation relation NN cord-104204-pdnkabwj 308 15 between between IN cord-104204-pdnkabwj 308 16 low low JJ cord-104204-pdnkabwj 308 17 - - HYPH cord-104204-pdnkabwj 308 18 rank rank NN cord-104204-pdnkabwj 308 19 coal coal NN cord-104204-pdnkabwj 308 20 deposits deposit NNS cord-104204-pdnkabwj 308 21 and and CC cord-104204-pdnkabwj 308 22 Balkan balkan JJ cord-104204-pdnkabwj 308 23 endemic endemic JJ cord-104204-pdnkabwj 308 24 nephropathy nephropathy NN cord-104204-pdnkabwj 309 1 Renal renal JJ cord-104204-pdnkabwj 309 2 changes change NNS cord-104204-pdnkabwj 309 3 in in IN cord-104204-pdnkabwj 309 4 rats rat NNS cord-104204-pdnkabwj 309 5 and and CC cord-104204-pdnkabwj 309 6 mice mouse NNS cord-104204-pdnkabwj 309 7 caused cause VBN cord-104204-pdnkabwj 309 8 by by IN cord-104204-pdnkabwj 309 9 total total JJ cord-104204-pdnkabwj 309 10 extracts extract NNS cord-104204-pdnkabwj 309 11 of of IN cord-104204-pdnkabwj 309 12 water water NN cord-104204-pdnkabwj 309 13 and and CC cord-104204-pdnkabwj 309 14 residue residue NN cord-104204-pdnkabwj 309 15 obtained obtain VBN cord-104204-pdnkabwj 309 16 from from IN cord-104204-pdnkabwj 309 17 a a DT cord-104204-pdnkabwj 309 18 herd herd NN cord-104204-pdnkabwj 309 19 with with IN cord-104204-pdnkabwj 309 20 endemic endemic JJ cord-104204-pdnkabwj 309 21 nephropathy nephropathy NN cord-104204-pdnkabwj 309 22 Geologia Geologia NNP cord-104204-pdnkabwj 309 23 zacamintelor zacamintelor NNP cord-104204-pdnkabwj 309 24 de de FW cord-104204-pdnkabwj 309 25 carbuni carbuni NNP cord-104204-pdnkabwj 309 26 -2 -2 NNP cord-104204-pdnkabwj 309 27 . . . cord-104204-pdnkabwj 310 1 Zacaminte Zacaminte NNP cord-104204-pdnkabwj 310 2 din din NN cord-104204-pdnkabwj 311 1 Romania Romania NNP cord-104204-pdnkabwj 311 2 CIBA CIBA NNP cord-104204-pdnkabwj 311 3 Foundation Foundation NNP cord-104204-pdnkabwj 311 4 Study Study NNP cord-104204-pdnkabwj 311 5 Group Group NNP cord-104204-pdnkabwj 311 6 No No NNP cord-104204-pdnkabwj 311 7 . . NN cord-104204-pdnkabwj 311 8 30 30 CD cord-104204-pdnkabwj 311 9 Urinary urinary JJ cord-104204-pdnkabwj 311 10 tract tract JJ cord-104204-pdnkabwj 311 11 tumors tumor NNS cord-104204-pdnkabwj 311 12 and and CC cord-104204-pdnkabwj 311 13 Balkan balkan JJ cord-104204-pdnkabwj 311 14 nephropathy nephropathy NN cord-104204-pdnkabwj 311 15 in in IN cord-104204-pdnkabwj 311 16 the the DT cord-104204-pdnkabwj 311 17 South South NNP cord-104204-pdnkabwj 311 18 Morava Morava NNP cord-104204-pdnkabwj 311 19 River River NNP cord-104204-pdnkabwj 311 20 basin basin NN cord-104204-pdnkabwj 311 21 Tumors tumor NNS cord-104204-pdnkabwj 311 22 of of IN cord-104204-pdnkabwj 311 23 the the DT cord-104204-pdnkabwj 311 24 pielum pielum NN cord-104204-pdnkabwj 311 25 and and CC cord-104204-pdnkabwj 311 26 ureter ureter NN cord-104204-pdnkabwj 311 27 in in IN cord-104204-pdnkabwj 311 28 emigrants emigrant NNS cord-104204-pdnkabwj 311 29 from from IN cord-104204-pdnkabwj 311 30 endemic endemic JJ cord-104204-pdnkabwj 311 31 nephropathy nephropathy NN cord-104204-pdnkabwj 311 32 areas area NNS cord-104204-pdnkabwj 312 1 The the DT cord-104204-pdnkabwj 312 2 role role NN cord-104204-pdnkabwj 312 3 of of IN cord-104204-pdnkabwj 312 4 individual individual JJ cord-104204-pdnkabwj 312 5 susceptibility susceptibility NN cord-104204-pdnkabwj 312 6 in in IN cord-104204-pdnkabwj 312 7 cancer cancer NN cord-104204-pdnkabwj 312 8 burden burden NN cord-104204-pdnkabwj 312 9 related relate VBN cord-104204-pdnkabwj 312 10 to to IN cord-104204-pdnkabwj 312 11 environmental environmental JJ cord-104204-pdnkabwj 312 12 exposure exposure NN cord-104204-pdnkabwj 312 13 Interaction Interaction NNP cord-104204-pdnkabwj 312 14 between between IN cord-104204-pdnkabwj 312 15 dose dose NN cord-104204-pdnkabwj 312 16 and and CC cord-104204-pdnkabwj 312 17 susceptibility susceptibility NN cord-104204-pdnkabwj 312 18 to to IN cord-104204-pdnkabwj 312 19 environmental environmental JJ cord-104204-pdnkabwj 312 20 cancer cancer NN cord-104204-pdnkabwj 312 21 : : : cord-104204-pdnkabwj 312 22 a a DT cord-104204-pdnkabwj 312 23 short short JJ cord-104204-pdnkabwj 312 24 review review NN cord-104204-pdnkabwj 312 25 Polymorphisms polymorphism NNS cord-104204-pdnkabwj 312 26 in in IN cord-104204-pdnkabwj 312 27 drug drug NN cord-104204-pdnkabwj 312 28 - - HYPH cord-104204-pdnkabwj 312 29 metabolizing metabolize VBG cord-104204-pdnkabwj 312 30 enzymes enzyme NNS cord-104204-pdnkabwj 312 31 : : : cord-104204-pdnkabwj 312 32 what what WP cord-104204-pdnkabwj 312 33 is be VBZ cord-104204-pdnkabwj 312 34 their -PRON- PRP$ cord-104204-pdnkabwj 312 35 clinical clinical JJ cord-104204-pdnkabwj 312 36 relevance relevance NN cord-104204-pdnkabwj 312 37 and and CC cord-104204-pdnkabwj 312 38 why why WRB cord-104204-pdnkabwj 312 39 do do VBP cord-104204-pdnkabwj 312 40 they -PRON- PRP cord-104204-pdnkabwj 312 41 exist exist VB cord-104204-pdnkabwj 312 42 ? ? . cord-104204-pdnkabwj 313 1 Genetic genetic JJ cord-104204-pdnkabwj 313 2 predisposition predisposition NN cord-104204-pdnkabwj 313 3 to to IN cord-104204-pdnkabwj 313 4 Balkan balkan JJ cord-104204-pdnkabwj 313 5 endemic endemic JJ cord-104204-pdnkabwj 313 6 nephropathy nephropathy NN cord-104204-pdnkabwj 313 7 : : : cord-104204-pdnkabwj 313 8 ability ability NN cord-104204-pdnkabwj 313 9 to to TO cord-104204-pdnkabwj 313 10 hydroxylate hydroxylate VB cord-104204-pdnkabwj 313 11 debrisoquine debrisoquine NN cord-104204-pdnkabwj 313 12 as as IN cord-104204-pdnkabwj 313 13 a a DT cord-104204-pdnkabwj 313 14 host host NN cord-104204-pdnkabwj 313 15 risk risk NN cord-104204-pdnkabwj 313 16 factor factor NN cord-104204-pdnkabwj 313 17 Characterization characterization NN cord-104204-pdnkabwj 313 18 of of IN cord-104204-pdnkabwj 313 19 the the DT cord-104204-pdnkabwj 313 20 cytochrome cytochrome NN cord-104204-pdnkabwj 313 21 P450 p450 JJ cord-104204-pdnkabwj 313 22 isozyme isozyme NNS cord-104204-pdnkabwj 313 23 that that WDT cord-104204-pdnkabwj 313 24 metabolizes metabolize VBZ cord-104204-pdnkabwj 313 25 ochratoxin ochratoxin NNP cord-104204-pdnkabwj 313 26 A A NNP cord-104204-pdnkabwj 313 27 , , , cord-104204-pdnkabwj 313 28 using use VBG cord-104204-pdnkabwj 313 29 metabolic metabolic JJ cord-104204-pdnkabwj 313 30 inducers inducer NNS cord-104204-pdnkabwj 313 31 , , , cord-104204-pdnkabwj 313 32 inhibitors inhibitor NNS cord-104204-pdnkabwj 313 33 and and CC cord-104204-pdnkabwj 313 34 antibodies antibody NNS cord-104204-pdnkabwj 313 35 Chronic chronic JJ cord-104204-pdnkabwj 313 36 interstitial interstitial JJ cord-104204-pdnkabwj 313 37 nephritis nephritis NN cord-104204-pdnkabwj 313 38 as as IN cord-104204-pdnkabwj 313 39 a a DT cord-104204-pdnkabwj 313 40 cause cause NN cord-104204-pdnkabwj 313 41 of of IN cord-104204-pdnkabwj 313 42 tumors tumor NNS cord-104204-pdnkabwj 313 43 of of IN cord-104204-pdnkabwj 313 44 the the DT cord-104204-pdnkabwj 313 45 upper upper JJ cord-104204-pdnkabwj 313 46 urinary urinary JJ cord-104204-pdnkabwj 313 47 tract tract NN cord-104204-pdnkabwj 313 48 Chinese chinese JJ cord-104204-pdnkabwj 313 49 herbs herb NNS cord-104204-pdnkabwj 313 50 nephropathy nephropathy NN cord-104204-pdnkabwj 313 51 : : : cord-104204-pdnkabwj 313 52 a a DT cord-104204-pdnkabwj 313 53 clue clue NN cord-104204-pdnkabwj 313 54 to to IN cord-104204-pdnkabwj 313 55 Balkan balkan JJ cord-104204-pdnkabwj 313 56 endemic endemic JJ cord-104204-pdnkabwj 313 57 nephropathy nephropathy NN cord-104204-pdnkabwj 313 58 ? ? . cord-104204-pdnkabwj 314 1 Traditional traditional JJ cord-104204-pdnkabwj 314 2 remedy remedy NN cord-104204-pdnkabwj 314 3 - - HYPH cord-104204-pdnkabwj 314 4 induced induce VBN cord-104204-pdnkabwj 314 5 Chinese chinese JJ cord-104204-pdnkabwj 314 6 herbs herb NNS cord-104204-pdnkabwj 314 7 nephropathy nephropathy IN cord-104204-pdnkabwj 314 8 showing show VBG cord-104204-pdnkabwj 314 9 rapid rapid JJ cord-104204-pdnkabwj 314 10 deterioration deterioration NN cord-104204-pdnkabwj 314 11 of of IN cord-104204-pdnkabwj 314 12 renal renal JJ cord-104204-pdnkabwj 314 13 function function NN cord-104204-pdnkabwj 314 14 Virus virus NN cord-104204-pdnkabwj 314 15 - - HYPH cord-104204-pdnkabwj 314 16 like like JJ cord-104204-pdnkabwj 314 17 particles particle NNS cord-104204-pdnkabwj 314 18 in in IN cord-104204-pdnkabwj 314 19 the the DT cord-104204-pdnkabwj 314 20 kidneys kidney NNS cord-104204-pdnkabwj 314 21 of of IN cord-104204-pdnkabwj 314 22 three three CD cord-104204-pdnkabwj 314 23 patients patient NNS cord-104204-pdnkabwj 314 24 with with IN cord-104204-pdnkabwj 314 25 endemic endemic JJ cord-104204-pdnkabwj 314 26 Balkan balkan JJ cord-104204-pdnkabwj 314 27 nephropathy nephropathy NN cord-104204-pdnkabwj 314 28 Serum serum NN cord-104204-pdnkabwj 314 29 antibodies antibody NNS cord-104204-pdnkabwj 314 30 to to TO cord-104204-pdnkabwj 314 31 papova papova VB cord-104204-pdnkabwj 314 32 viruses virus NNS cord-104204-pdnkabwj 314 33 ( ( -LRB- cord-104204-pdnkabwj 314 34 BK BK NNP cord-104204-pdnkabwj 314 35 and and CC cord-104204-pdnkabwj 314 36 SV40 SV40 NNP cord-104204-pdnkabwj 314 37 ) ) -RRB- cord-104204-pdnkabwj 314 38 in in IN cord-104204-pdnkabwj 314 39 subjects subject NNS cord-104204-pdnkabwj 314 40 from from IN cord-104204-pdnkabwj 314 41 the the DT cord-104204-pdnkabwj 314 42 area area NN cord-104204-pdnkabwj 314 43 with with IN cord-104204-pdnkabwj 314 44 Balkan balkan JJ cord-104204-pdnkabwj 314 45 endemic endemic JJ cord-104204-pdnkabwj 314 46 nephropathy nephropathy NN cord-104204-pdnkabwj 314 47 Further further JJ cord-104204-pdnkabwj 314 48 data datum NNS cord-104204-pdnkabwj 314 49 on on IN cord-104204-pdnkabwj 314 50 the the DT cord-104204-pdnkabwj 314 51 prevalence prevalence NN cord-104204-pdnkabwj 314 52 of of IN cord-104204-pdnkabwj 314 53 serum serum NN cord-104204-pdnkabwj 314 54 antibodies antibody NNS cord-104204-pdnkabwj 314 55 to to IN cord-104204-pdnkabwj 314 56 papova papova VB cord-104204-pdnkabwj 314 57 viruses virus NNS cord-104204-pdnkabwj 314 58 ( ( -LRB- cord-104204-pdnkabwj 314 59 BK BK NNP cord-104204-pdnkabwj 314 60 and and CC cord-104204-pdnkabwj 314 61 SV40 SV40 NNP cord-104204-pdnkabwj 314 62 ) ) -RRB- cord-104204-pdnkabwj 314 63 in in IN cord-104204-pdnkabwj 314 64 subjects subject NNS cord-104204-pdnkabwj 314 65 from from IN cord-104204-pdnkabwj 314 66 the the DT cord-104204-pdnkabwj 314 67 Romanian romanian JJ cord-104204-pdnkabwj 314 68 area area NN cord-104204-pdnkabwj 314 69 with with IN cord-104204-pdnkabwj 314 70 Balkan balkan JJ cord-104204-pdnkabwj 314 71 endemic endemic JJ cord-104204-pdnkabwj 314 72 nephropathy nephropathy NN cord-104204-pdnkabwj 314 73 Epidemiological epidemiological JJ cord-104204-pdnkabwj 314 74 evidence evidence NN cord-104204-pdnkabwj 314 75 on on IN cord-104204-pdnkabwj 314 76 Balkan balkan JJ cord-104204-pdnkabwj 314 77 nephropathy nephropathy NN cord-104204-pdnkabwj 314 78 as as IN cord-104204-pdnkabwj 314 79 a a DT cord-104204-pdnkabwj 314 80 viral viral JJ cord-104204-pdnkabwj 314 81 disease disease NN cord-104204-pdnkabwj 314 82 Infections infection NNS cord-104204-pdnkabwj 314 83 caused cause VBN cord-104204-pdnkabwj 314 84 by by IN cord-104204-pdnkabwj 314 85 arthropod arthropod NN cord-104204-pdnkabwj 314 86 - - HYPH cord-104204-pdnkabwj 314 87 and and CC cord-104204-pdnkabwj 314 88 rodent rodent NN cord-104204-pdnkabwj 314 89 - - HYPH cord-104204-pdnkabwj 314 90 borne bear VBN cord-104204-pdnkabwj 314 91 virus virus NN cord-104204-pdnkabwj 315 1 The the DT cord-104204-pdnkabwj 315 2 health health NN cord-104204-pdnkabwj 315 3 impact impact NN cord-104204-pdnkabwj 315 4 of of IN cord-104204-pdnkabwj 315 5 geochemical geochemical JJ cord-104204-pdnkabwj 315 6 alterations alteration NNS cord-104204-pdnkabwj 315 7 associated associate VBN cord-104204-pdnkabwj 315 8 with with IN cord-104204-pdnkabwj 315 9 coal coal NN cord-104204-pdnkabwj 315 10 resource resource NN cord-104204-pdnkabwj 315 11 development development NN cord-104204-pdnkabwj 315 12 in in IN cord-104204-pdnkabwj 315 13 Midwestern Midwestern NNP cord-104204-pdnkabwj 315 14 USA USA NNP cord-104204-pdnkabwj 315 15 Heart Heart NNP cord-104204-pdnkabwj 315 16 disease disease NN cord-104204-pdnkabwj 315 17 and and CC cord-104204-pdnkabwj 315 18 geologic geologic JJ cord-104204-pdnkabwj 315 19 setting setting NN cord-104204-pdnkabwj 315 20 in in IN cord-104204-pdnkabwj 315 21 Ohio Ohio NNP cord-104204-pdnkabwj 315 22 Chemical Chemical NNP cord-104204-pdnkabwj 315 23 qualities quality NNS cord-104204-pdnkabwj 315 24 of of IN cord-104204-pdnkabwj 315 25 water water NN cord-104204-pdnkabwj 315 26 that that WDT cord-104204-pdnkabwj 315 27 contribute contribute VBP cord-104204-pdnkabwj 315 28 to to IN cord-104204-pdnkabwj 315 29 human human JJ cord-104204-pdnkabwj 315 30 health health NN cord-104204-pdnkabwj 315 31 in in IN cord-104204-pdnkabwj 315 32 a a DT cord-104204-pdnkabwj 315 33 positive positive JJ cord-104204-pdnkabwj 315 34 way way NN