id	sid	tid	token	lemma	pos
cord-262253-3ovqhypt	1	1	key	key	NN
cord-262253-3ovqhypt	1	2	:	:	:
cord-262253-3ovqhypt	2	1	cord-262253	cord-262253	JJ
cord-262253-3ovqhypt	2	2	-	-	HYPH
cord-262253-3ovqhypt	2	3	3ovqhypt	3ovqhypt	CD
cord-262253-3ovqhypt	2	4	authors	author	NNS
cord-262253-3ovqhypt	2	5	:	:	:
cord-262253-3ovqhypt	2	6	Iqbal	Iqbal	NNP
cord-262253-3ovqhypt	2	7	,	,	,
cord-262253-3ovqhypt	2	8	Umar	Umar	NNP
cord-262253-3ovqhypt	2	9	H.	H.	NNP
cord-262253-3ovqhypt	2	10	;	;	:
cord-262253-3ovqhypt	2	11	Zeng	Zeng	NNP
cord-262253-3ovqhypt	2	12	,	,	,
cord-262253-3ovqhypt	2	13	Emma	Emma	NNP
cord-262253-3ovqhypt	2	14	;	;	:
cord-262253-3ovqhypt	2	15	Pasinetti	Pasinetti	NNP
cord-262253-3ovqhypt	2	16	,	,	,
cord-262253-3ovqhypt	2	17	Giulio	Giulio	NNP
cord-262253-3ovqhypt	2	18	M.	M.	NNP
cord-262253-3ovqhypt	2	19	title	title	NN
cord-262253-3ovqhypt	2	20	:	:	:
cord-262253-3ovqhypt	3	1	The	the	DT
cord-262253-3ovqhypt	3	2	Use	Use	NNP
cord-262253-3ovqhypt	3	3	of	of	IN
cord-262253-3ovqhypt	3	4	Antimicrobial	Antimicrobial	NNP
cord-262253-3ovqhypt	3	5	and	and	CC
cord-262253-3ovqhypt	3	6	Antiviral	Antiviral	NNP
cord-262253-3ovqhypt	3	7	Drugs	Drugs	NNPS
cord-262253-3ovqhypt	3	8	in	in	IN
cord-262253-3ovqhypt	3	9	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	3	10	’s	’s	POS
cord-262253-3ovqhypt	3	11	Disease	Disease	NNP
cord-262253-3ovqhypt	3	12	date	date	NN
cord-262253-3ovqhypt	3	13	:	:	:
cord-262253-3ovqhypt	3	14	2020	2020	CD
cord-262253-3ovqhypt	3	15	-	-	HYPH
cord-262253-3ovqhypt	3	16	07	07	CD
cord-262253-3ovqhypt	3	17	-	-	HYPH
cord-262253-3ovqhypt	3	18	12	12	CD
cord-262253-3ovqhypt	3	19	journal	journal	NN
cord-262253-3ovqhypt	3	20	:	:	:
cord-262253-3ovqhypt	4	1	Int	Int	NNP
cord-262253-3ovqhypt	4	2	J	J	NNP
cord-262253-3ovqhypt	4	3	Mol	Mol	NNP
cord-262253-3ovqhypt	4	4	Sci	Sci	NNP
cord-262253-3ovqhypt	4	5	DOI	DOI	NNP
cord-262253-3ovqhypt	5	1	:	:	:
cord-262253-3ovqhypt	5	2	10.3390	10.3390	CD
cord-262253-3ovqhypt	5	3	/	/	SYM
cord-262253-3ovqhypt	5	4	ijms21144920	ijms21144920	NN
cord-262253-3ovqhypt	5	5	sha	sha	NNP
cord-262253-3ovqhypt	5	6	:	:	:
cord-262253-3ovqhypt	6	1	3274d6d3fae9969cb974d7989ea86d383a40fa06	3274d6d3fae9969cb974d7989ea86d383a40fa06	CD
cord-262253-3ovqhypt	6	2	doc_id	doc_id	CD
cord-262253-3ovqhypt	6	3	:	:	:
cord-262253-3ovqhypt	6	4	262253	262253	CD
cord-262253-3ovqhypt	6	5	cord_uid	cord_uid	NNS
cord-262253-3ovqhypt	6	6	:	:	:
cord-262253-3ovqhypt	7	1	3ovqhypt	3ovqhypt	CD
cord-262253-3ovqhypt	8	1	The	the	DT
cord-262253-3ovqhypt	8	2	aggregation	aggregation	NN
cord-262253-3ovqhypt	8	3	and	and	CC
cord-262253-3ovqhypt	8	4	accumulation	accumulation	NN
cord-262253-3ovqhypt	8	5	of	of	IN
cord-262253-3ovqhypt	8	6	amyloid	amyloid	NN
cord-262253-3ovqhypt	8	7	-	-	HYPH
cord-262253-3ovqhypt	8	8	β	β	NN
cord-262253-3ovqhypt	8	9	plaques	plaque	NNS
cord-262253-3ovqhypt	8	10	and	and	CC
cord-262253-3ovqhypt	8	11	tau	tau	NN
cord-262253-3ovqhypt	8	12	proteins	protein	NNS
cord-262253-3ovqhypt	8	13	in	in	IN
cord-262253-3ovqhypt	8	14	the	the	DT
cord-262253-3ovqhypt	8	15	brain	brain	NN
cord-262253-3ovqhypt	8	16	have	have	VBP
cord-262253-3ovqhypt	8	17	been	be	VBN
cord-262253-3ovqhypt	8	18	central	central	JJ
cord-262253-3ovqhypt	8	19	characteristics	characteristic	NNS
cord-262253-3ovqhypt	8	20	in	in	IN
cord-262253-3ovqhypt	8	21	the	the	DT
cord-262253-3ovqhypt	8	22	pathophysiology	pathophysiology	NN
cord-262253-3ovqhypt	8	23	of	of	IN
cord-262253-3ovqhypt	8	24	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	8	25	’s	’s	POS
cord-262253-3ovqhypt	8	26	disease	disease	NN
cord-262253-3ovqhypt	8	27	(	(	-LRB-
cord-262253-3ovqhypt	8	28	AD	ad	NN
cord-262253-3ovqhypt	8	29	)	)	-RRB-
cord-262253-3ovqhypt	8	30	,	,	,
cord-262253-3ovqhypt	8	31	making	make	VBG
cord-262253-3ovqhypt	8	32	them	-PRON-	PRP
cord-262253-3ovqhypt	8	33	the	the	DT
cord-262253-3ovqhypt	8	34	focus	focus	NN
cord-262253-3ovqhypt	8	35	of	of	IN
cord-262253-3ovqhypt	8	36	most	most	JJS
cord-262253-3ovqhypt	8	37	of	of	IN
cord-262253-3ovqhypt	8	38	the	the	DT
cord-262253-3ovqhypt	8	39	research	research	NN
cord-262253-3ovqhypt	8	40	exploring	explore	VBG
cord-262253-3ovqhypt	8	41	potential	potential	JJ
cord-262253-3ovqhypt	8	42	therapeutics	therapeutic	NNS
cord-262253-3ovqhypt	8	43	for	for	IN
cord-262253-3ovqhypt	8	44	this	this	DT
cord-262253-3ovqhypt	8	45	neurodegenerative	neurodegenerative	JJ
cord-262253-3ovqhypt	8	46	disease	disease	NN
cord-262253-3ovqhypt	8	47	.	.	.
cord-262253-3ovqhypt	9	1	With	with	IN
cord-262253-3ovqhypt	9	2	success	success	NN
cord-262253-3ovqhypt	9	3	in	in	IN
cord-262253-3ovqhypt	9	4	interventions	intervention	NNS
cord-262253-3ovqhypt	9	5	aimed	aim	VBN
cord-262253-3ovqhypt	9	6	at	at	IN
cord-262253-3ovqhypt	9	7	depleting	deplete	VBG
cord-262253-3ovqhypt	9	8	amyloid	amyloid	NN
cord-262253-3ovqhypt	9	9	-	-	HYPH
cord-262253-3ovqhypt	9	10	β	β	NN
cord-262253-3ovqhypt	9	11	peptides	peptide	NNS
cord-262253-3ovqhypt	9	12	being	be	VBG
cord-262253-3ovqhypt	9	13	limited	limit	VBN
cord-262253-3ovqhypt	9	14	at	at	IN
cord-262253-3ovqhypt	9	15	best	well	RBS
cord-262253-3ovqhypt	9	16	,	,	,
cord-262253-3ovqhypt	9	17	a	a	DT
cord-262253-3ovqhypt	9	18	greater	great	JJR
cord-262253-3ovqhypt	9	19	understanding	understanding	NN
cord-262253-3ovqhypt	9	20	of	of	IN
cord-262253-3ovqhypt	9	21	the	the	DT
cord-262253-3ovqhypt	9	22	physiological	physiological	JJ
cord-262253-3ovqhypt	9	23	role	role	NN
cord-262253-3ovqhypt	9	24	of	of	IN
cord-262253-3ovqhypt	9	25	amyloid	amyloid	NN
cord-262253-3ovqhypt	9	26	-	-	HYPH
cord-262253-3ovqhypt	9	27	β	β	NN
cord-262253-3ovqhypt	9	28	peptides	peptide	NNS
cord-262253-3ovqhypt	9	29	is	be	VBZ
cord-262253-3ovqhypt	9	30	needed	need	VBN
cord-262253-3ovqhypt	9	31	.	.	.
cord-262253-3ovqhypt	10	1	The	the	DT
cord-262253-3ovqhypt	10	2	development	development	NN
cord-262253-3ovqhypt	10	3	of	of	IN
cord-262253-3ovqhypt	10	4	amyloid	amyloid	NN
cord-262253-3ovqhypt	10	5	-	-	HYPH
cord-262253-3ovqhypt	10	6	β	β	NN
cord-262253-3ovqhypt	10	7	plaques	plaque	NNS
cord-262253-3ovqhypt	10	8	has	have	VBZ
cord-262253-3ovqhypt	10	9	been	be	VBN
cord-262253-3ovqhypt	10	10	determined	determine	VBN
cord-262253-3ovqhypt	10	11	to	to	TO
cord-262253-3ovqhypt	10	12	occur	occur	VB
cord-262253-3ovqhypt	10	13	10–20	10–20	CD
cord-262253-3ovqhypt	10	14	years	year	NNS
cord-262253-3ovqhypt	10	15	prior	prior	RB
cord-262253-3ovqhypt	10	16	to	to	IN
cord-262253-3ovqhypt	10	17	AD	ad	NN
cord-262253-3ovqhypt	10	18	symptom	symptom	NN
cord-262253-3ovqhypt	10	19	manifestation	manifestation	NN
cord-262253-3ovqhypt	10	20	,	,	,
cord-262253-3ovqhypt	10	21	hence	hence	RB
cord-262253-3ovqhypt	10	22	earlier	early	JJR
cord-262253-3ovqhypt	10	23	interventions	intervention	NNS
cord-262253-3ovqhypt	10	24	might	may	MD
cord-262253-3ovqhypt	10	25	be	be	VB
cord-262253-3ovqhypt	10	26	necessary	necessary	JJ
cord-262253-3ovqhypt	10	27	to	to	TO
cord-262253-3ovqhypt	10	28	address	address	VB
cord-262253-3ovqhypt	10	29	presymptomatic	presymptomatic	JJ
cord-262253-3ovqhypt	10	30	AD	ad	NN
cord-262253-3ovqhypt	10	31	.	.	.
cord-262253-3ovqhypt	11	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	11	2	,	,	,
cord-262253-3ovqhypt	11	3	recent	recent	JJ
cord-262253-3ovqhypt	11	4	studies	study	NNS
cord-262253-3ovqhypt	11	5	have	have	VBP
cord-262253-3ovqhypt	11	6	suggested	suggest	VBN
cord-262253-3ovqhypt	11	7	that	that	IN
cord-262253-3ovqhypt	11	8	amyloid	amyloid	NN
cord-262253-3ovqhypt	11	9	-	-	HYPH
cord-262253-3ovqhypt	11	10	β	β	NN
cord-262253-3ovqhypt	11	11	peptides	peptide	NNS
cord-262253-3ovqhypt	11	12	may	may	MD
cord-262253-3ovqhypt	11	13	play	play	VB
cord-262253-3ovqhypt	11	14	a	a	DT
cord-262253-3ovqhypt	11	15	role	role	NN
cord-262253-3ovqhypt	11	16	in	in	IN
cord-262253-3ovqhypt	11	17	innate	innate	JJ
cord-262253-3ovqhypt	11	18	immunity	immunity	NN
cord-262253-3ovqhypt	11	19	as	as	IN
cord-262253-3ovqhypt	11	20	an	an	DT
cord-262253-3ovqhypt	11	21	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	11	22	peptide	peptide	NN
cord-262253-3ovqhypt	11	23	.	.	.
cord-262253-3ovqhypt	12	1	These	these	DT
cord-262253-3ovqhypt	12	2	findings	finding	NNS
cord-262253-3ovqhypt	12	3	,	,	,
cord-262253-3ovqhypt	12	4	coupled	couple	VBN
cord-262253-3ovqhypt	12	5	with	with	IN
cord-262253-3ovqhypt	12	6	the	the	DT
cord-262253-3ovqhypt	12	7	evidence	evidence	NN
cord-262253-3ovqhypt	12	8	of	of	IN
cord-262253-3ovqhypt	12	9	pathogens	pathogen	NNS
cord-262253-3ovqhypt	12	10	such	such	JJ
cord-262253-3ovqhypt	12	11	as	as	IN
cord-262253-3ovqhypt	12	12	viruses	virus	NNS
cord-262253-3ovqhypt	12	13	and	and	CC
cord-262253-3ovqhypt	12	14	bacteria	bacteria	NNS
cord-262253-3ovqhypt	12	15	in	in	IN
cord-262253-3ovqhypt	12	16	AD	ad	NN
cord-262253-3ovqhypt	12	17	brains	brain	NNS
cord-262253-3ovqhypt	12	18	,	,	,
cord-262253-3ovqhypt	12	19	suggests	suggest	VBZ
cord-262253-3ovqhypt	12	20	that	that	IN
cord-262253-3ovqhypt	12	21	the	the	DT
cord-262253-3ovqhypt	12	22	buildup	buildup	NN
cord-262253-3ovqhypt	12	23	of	of	IN
cord-262253-3ovqhypt	12	24	amyloid	amyloid	NN
cord-262253-3ovqhypt	12	25	-	-	HYPH
cord-262253-3ovqhypt	12	26	β	β	NN
cord-262253-3ovqhypt	12	27	plaques	plaque	NNS
cord-262253-3ovqhypt	12	28	could	could	MD
cord-262253-3ovqhypt	12	29	be	be	VB
cord-262253-3ovqhypt	12	30	a	a	DT
cord-262253-3ovqhypt	12	31	response	response	NN
cord-262253-3ovqhypt	12	32	to	to	IN
cord-262253-3ovqhypt	12	33	the	the	DT
cord-262253-3ovqhypt	12	34	presence	presence	NN
cord-262253-3ovqhypt	12	35	of	of	IN
cord-262253-3ovqhypt	12	36	viruses	virus	NNS
cord-262253-3ovqhypt	12	37	and	and	CC
cord-262253-3ovqhypt	12	38	bacteria	bacteria	NNS
cord-262253-3ovqhypt	12	39	.	.	.
cord-262253-3ovqhypt	13	1	This	this	DT
cord-262253-3ovqhypt	13	2	has	have	VBZ
cord-262253-3ovqhypt	13	3	led	lead	VBN
cord-262253-3ovqhypt	13	4	to	to	IN
cord-262253-3ovqhypt	13	5	the	the	DT
cord-262253-3ovqhypt	13	6	foundation	foundation	NN
cord-262253-3ovqhypt	13	7	of	of	IN
cord-262253-3ovqhypt	13	8	the	the	DT
cord-262253-3ovqhypt	13	9	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	13	10	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	13	11	for	for	IN
cord-262253-3ovqhypt	13	12	AD	ad	NN
cord-262253-3ovqhypt	13	13	.	.	.
cord-262253-3ovqhypt	14	1	The	the	DT
cord-262253-3ovqhypt	14	2	present	present	JJ
cord-262253-3ovqhypt	14	3	review	review	NN
cord-262253-3ovqhypt	14	4	will	will	MD
cord-262253-3ovqhypt	14	5	highlight	highlight	VB
cord-262253-3ovqhypt	14	6	the	the	DT
cord-262253-3ovqhypt	14	7	current	current	JJ
cord-262253-3ovqhypt	14	8	understanding	understanding	NN
cord-262253-3ovqhypt	14	9	of	of	IN
cord-262253-3ovqhypt	14	10	amyloid	amyloid	NN
cord-262253-3ovqhypt	14	11	-	-	HYPH
cord-262253-3ovqhypt	14	12	β	β	NN
cord-262253-3ovqhypt	14	13	,	,	,
cord-262253-3ovqhypt	14	14	and	and	CC
cord-262253-3ovqhypt	14	15	the	the	DT
cord-262253-3ovqhypt	14	16	role	role	NN
cord-262253-3ovqhypt	14	17	of	of	IN
cord-262253-3ovqhypt	14	18	bacteria	bacteria	NNS
cord-262253-3ovqhypt	14	19	and	and	CC
cord-262253-3ovqhypt	14	20	viruses	virus	NNS
cord-262253-3ovqhypt	14	21	in	in	IN
cord-262253-3ovqhypt	14	22	AD	ad	NN
cord-262253-3ovqhypt	14	23	,	,	,
cord-262253-3ovqhypt	14	24	and	and	CC
cord-262253-3ovqhypt	14	25	will	will	MD
cord-262253-3ovqhypt	14	26	also	also	RB
cord-262253-3ovqhypt	14	27	explore	explore	VB
cord-262253-3ovqhypt	14	28	the	the	DT
cord-262253-3ovqhypt	14	29	therapeutic	therapeutic	JJ
cord-262253-3ovqhypt	14	30	potential	potential	NN
cord-262253-3ovqhypt	14	31	of	of	IN
cord-262253-3ovqhypt	14	32	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	14	33	and	and	CC
cord-262253-3ovqhypt	14	34	antiviral	antiviral	JJ
cord-262253-3ovqhypt	14	35	drugs	drug	NNS
cord-262253-3ovqhypt	14	36	in	in	IN
cord-262253-3ovqhypt	14	37	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	14	38	’s	’s	POS
cord-262253-3ovqhypt	14	39	disease	disease	NN
cord-262253-3ovqhypt	14	40	.	.	.
cord-262253-3ovqhypt	15	1	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	15	2	's	's	POS
cord-262253-3ovqhypt	15	3	disease	disease	NN
cord-262253-3ovqhypt	15	4	(	(	-LRB-
cord-262253-3ovqhypt	15	5	AD	ad	NN
cord-262253-3ovqhypt	15	6	)	)	-RRB-
cord-262253-3ovqhypt	15	7	is	be	VBZ
cord-262253-3ovqhypt	15	8	a	a	DT
cord-262253-3ovqhypt	15	9	progressive	progressive	JJ
cord-262253-3ovqhypt	15	10	neurological	neurological	JJ
cord-262253-3ovqhypt	15	11	disorder	disorder	NN
cord-262253-3ovqhypt	15	12	that	that	WDT
cord-262253-3ovqhypt	15	13	accounts	account	VBZ
cord-262253-3ovqhypt	15	14	for	for	IN
cord-262253-3ovqhypt	15	15	the	the	DT
cord-262253-3ovqhypt	15	16	greatest	great	JJS
cord-262253-3ovqhypt	15	17	number	number	NN
cord-262253-3ovqhypt	15	18	of	of	IN
cord-262253-3ovqhypt	15	19	dementia	dementia	NN
cord-262253-3ovqhypt	15	20	cases	case	NNS
cord-262253-3ovqhypt	15	21	.	.	.
cord-262253-3ovqhypt	16	1	As	as	IN
cord-262253-3ovqhypt	16	2	of	of	IN
cord-262253-3ovqhypt	16	3	2019	2019	CD
cord-262253-3ovqhypt	16	4	,	,	,
cord-262253-3ovqhypt	16	5	5.8	5.8	CD
cord-262253-3ovqhypt	16	6	million	million	CD
cord-262253-3ovqhypt	16	7	people	people	NNS
cord-262253-3ovqhypt	16	8	were	be	VBD
cord-262253-3ovqhypt	16	9	living	live	VBG
cord-262253-3ovqhypt	16	10	with	with	IN
cord-262253-3ovqhypt	16	11	AD	ad	NN
cord-262253-3ovqhypt	16	12	,	,	,
cord-262253-3ovqhypt	16	13	with	with	IN
cord-262253-3ovqhypt	16	14	its	-PRON-	PRP$
cord-262253-3ovqhypt	16	15	prevalence	prevalence	NN
cord-262253-3ovqhypt	16	16	predicted	predict	VBN
cord-262253-3ovqhypt	16	17	to	to	TO
cord-262253-3ovqhypt	16	18	increase	increase	VB
cord-262253-3ovqhypt	16	19	to	to	IN
cord-262253-3ovqhypt	16	20	13.8	13.8	CD
cord-262253-3ovqhypt	16	21	million	million	CD
cord-262253-3ovqhypt	16	22	by	by	IN
cord-262253-3ovqhypt	16	23	2050	2050	CD
cord-262253-3ovqhypt	16	24	[	[	-LRB-
cord-262253-3ovqhypt	16	25	1	1	CD
cord-262253-3ovqhypt	16	26	]	]	-RRB-
cord-262253-3ovqhypt	16	27	.	.	.
cord-262253-3ovqhypt	17	1	The	the	DT
cord-262253-3ovqhypt	17	2	vast	vast	JJ
cord-262253-3ovqhypt	17	3	majority	majority	NN
cord-262253-3ovqhypt	17	4	of	of	IN
cord-262253-3ovqhypt	17	5	cases	case	NNS
cord-262253-3ovqhypt	17	6	are	be	VBP
cord-262253-3ovqhypt	17	7	concentrated	concentrate	VBN
cord-262253-3ovqhypt	17	8	in	in	IN
cord-262253-3ovqhypt	17	9	ages	age	NNS
cord-262253-3ovqhypt	17	10	over	over	IN
cord-262253-3ovqhypt	17	11	65	65	CD
cord-262253-3ovqhypt	17	12	,	,	,
cord-262253-3ovqhypt	17	13	impacting	impact	VBG
cord-262253-3ovqhypt	17	14	10	10	CD
cord-262253-3ovqhypt	17	15	%	%	NN
cord-262253-3ovqhypt	17	16	of	of	IN
cord-262253-3ovqhypt	17	17	people	people	NNS
cord-262253-3ovqhypt	17	18	in	in	IN
cord-262253-3ovqhypt	17	19	this	this	DT
cord-262253-3ovqhypt	17	20	age	age	NN
cord-262253-3ovqhypt	17	21	group	group	NN
cord-262253-3ovqhypt	17	22	.	.	.
cord-262253-3ovqhypt	18	1	In	in	IN
cord-262253-3ovqhypt	18	2	addition	addition	NN
cord-262253-3ovqhypt	18	3	,	,	,
cord-262253-3ovqhypt	18	4	the	the	DT
cord-262253-3ovqhypt	18	5	economic	economic	JJ
cord-262253-3ovqhypt	18	6	toll	toll	NN
cord-262253-3ovqhypt	18	7	of	of	IN
cord-262253-3ovqhypt	18	8	AD	ad	NN
cord-262253-3ovqhypt	18	9	on	on	IN
cord-262253-3ovqhypt	18	10	the	the	DT
cord-262253-3ovqhypt	18	11	United	United	NNP
cord-262253-3ovqhypt	18	12	States	States	NNP
cord-262253-3ovqhypt	18	13	economy	economy	NN
cord-262253-3ovqhypt	18	14	is	be	VBZ
cord-262253-3ovqhypt	18	15	significant	significant	JJ
cord-262253-3ovqhypt	18	16	,	,	,
cord-262253-3ovqhypt	18	17	estimated	estimate	VBN
cord-262253-3ovqhypt	18	18	to	to	TO
cord-262253-3ovqhypt	18	19	be	be	VB
cord-262253-3ovqhypt	18	20	roughly	roughly	RB
cord-262253-3ovqhypt	18	21	USD	usd	CD
cord-262253-3ovqhypt	18	22	290	290	CD
cord-262253-3ovqhypt	18	23	billion	billion	CD
cord-262253-3ovqhypt	18	24	in	in	IN
cord-262253-3ovqhypt	18	25	2019	2019	CD
cord-262253-3ovqhypt	18	26	[	[	-LRB-
cord-262253-3ovqhypt	18	27	1	1	CD
cord-262253-3ovqhypt	18	28	]	]	-RRB-
cord-262253-3ovqhypt	18	29	.	.	.
cord-262253-3ovqhypt	19	1	As	as	IN
cord-262253-3ovqhypt	19	2	the	the	DT
cord-262253-3ovqhypt	19	3	number	number	NN
cord-262253-3ovqhypt	19	4	of	of	IN
cord-262253-3ovqhypt	19	5	cases	case	NNS
cord-262253-3ovqhypt	19	6	is	be	VBZ
cord-262253-3ovqhypt	19	7	only	only	RB
cord-262253-3ovqhypt	19	8	expected	expect	VBN
cord-262253-3ovqhypt	19	9	to	to	TO
cord-262253-3ovqhypt	19	10	rise	rise	VB
cord-262253-3ovqhypt	19	11	over	over	IN
cord-262253-3ovqhypt	19	12	the	the	DT
cord-262253-3ovqhypt	19	13	coming	come	VBG
cord-262253-3ovqhypt	19	14	decades	decade	NNS
cord-262253-3ovqhypt	19	15	,	,	,
cord-262253-3ovqhypt	19	16	research	research	NN
cord-262253-3ovqhypt	19	17	in	in	IN
cord-262253-3ovqhypt	19	18	this	this	DT
cord-262253-3ovqhypt	19	19	field	field	NN
cord-262253-3ovqhypt	19	20	is	be	VBZ
cord-262253-3ovqhypt	19	21	critical	critical	JJ
cord-262253-3ovqhypt	19	22	in	in	IN
cord-262253-3ovqhypt	19	23	order	order	NN
cord-262253-3ovqhypt	19	24	to	to	TO
cord-262253-3ovqhypt	19	25	understand	understand	VB
cord-262253-3ovqhypt	19	26	the	the	DT
cord-262253-3ovqhypt	19	27	pathology	pathology	NN
cord-262253-3ovqhypt	19	28	of	of	IN
cord-262253-3ovqhypt	19	29	this	this	DT
cord-262253-3ovqhypt	19	30	disease	disease	NN
cord-262253-3ovqhypt	19	31	,	,	,
cord-262253-3ovqhypt	19	32	as	as	RB
cord-262253-3ovqhypt	19	33	well	well	RB
cord-262253-3ovqhypt	19	34	as	as	IN
cord-262253-3ovqhypt	19	35	potential	potential	JJ
cord-262253-3ovqhypt	19	36	therapeutics	therapeutic	NNS
cord-262253-3ovqhypt	19	37	.	.	.
cord-262253-3ovqhypt	20	1	The	the	DT
cord-262253-3ovqhypt	20	2	understanding	understanding	NN
cord-262253-3ovqhypt	20	3	and	and	CC
cord-262253-3ovqhypt	20	4	characterization	characterization	NN
cord-262253-3ovqhypt	20	5	of	of	IN
cord-262253-3ovqhypt	20	6	AD	ad	NN
cord-262253-3ovqhypt	20	7	can	can	MD
cord-262253-3ovqhypt	20	8	be	be	VB
cord-262253-3ovqhypt	20	9	traced	trace	VBN
cord-262253-3ovqhypt	20	10	back	back	RB
cord-262253-3ovqhypt	20	11	over	over	IN
cord-262253-3ovqhypt	20	12	100	100	CD
cord-262253-3ovqhypt	20	13	years	year	NNS
cord-262253-3ovqhypt	20	14	to	to	IN
cord-262253-3ovqhypt	20	15	Alois	Alois	NNP
cord-262253-3ovqhypt	20	16	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	20	17	,	,	,
cord-262253-3ovqhypt	20	18	from	from	IN
cord-262253-3ovqhypt	20	19	whom	whom	WP
cord-262253-3ovqhypt	20	20	the	the	DT
cord-262253-3ovqhypt	20	21	disease	disease	NN
cord-262253-3ovqhypt	20	22	takes	take	VBZ
cord-262253-3ovqhypt	20	23	its	-PRON-	PRP$
cord-262253-3ovqhypt	20	24	name	name	NN
cord-262253-3ovqhypt	20	25	.	.	.
cord-262253-3ovqhypt	21	1	After	after	IN
cord-262253-3ovqhypt	21	2	completing	complete	VBG
cord-262253-3ovqhypt	21	3	an	an	DT
cord-262253-3ovqhypt	21	4	autopsy	autopsy	NN
cord-262253-3ovqhypt	21	5	of	of	IN
cord-262253-3ovqhypt	21	6	a	a	DT
cord-262253-3ovqhypt	21	7	patient	patient	NN
cord-262253-3ovqhypt	21	8	with	with	IN
cord-262253-3ovqhypt	21	9	progressive	progressive	JJ
cord-262253-3ovqhypt	21	10	dementia	dementia	NN
cord-262253-3ovqhypt	21	11	,	,	,
cord-262253-3ovqhypt	21	12	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	21	13	noticed	notice	VBD
cord-262253-3ovqhypt	21	14	a	a	DT
cord-262253-3ovqhypt	21	15	severe	severe	JJ
cord-262253-3ovqhypt	21	16	amount	amount	NN
cord-262253-3ovqhypt	21	17	of	of	IN
cord-262253-3ovqhypt	21	18	cortical	cortical	JJ
cord-262253-3ovqhypt	21	19	degeneration	degeneration	NN
cord-262253-3ovqhypt	21	20	and	and	CC
cord-262253-3ovqhypt	21	21	an	an	DT
cord-262253-3ovqhypt	21	22	accumulation	accumulation	NN
cord-262253-3ovqhypt	21	23	of	of	IN
cord-262253-3ovqhypt	21	24	protein	protein	NN
cord-262253-3ovqhypt	21	25	deposits	deposit	NNS
cord-262253-3ovqhypt	21	26	,	,	,
cord-262253-3ovqhypt	21	27	specifically	specifically	RB
cord-262253-3ovqhypt	21	28	extraneuronal	extraneuronal	JJ
cord-262253-3ovqhypt	21	29	plaques	plaque	NNS
cord-262253-3ovqhypt	21	30	and	and	CC
cord-262253-3ovqhypt	21	31	intraneural	intraneural	JJ
cord-262253-3ovqhypt	21	32	tangles	tangle	NNS
cord-262253-3ovqhypt	21	33	[	[	-LRB-
cord-262253-3ovqhypt	21	34	2	2	CD
cord-262253-3ovqhypt	21	35	]	]	-RRB-
cord-262253-3ovqhypt	21	36	.	.	.
cord-262253-3ovqhypt	22	1	By	by	IN
cord-262253-3ovqhypt	22	2	1991	1991	CD
cord-262253-3ovqhypt	22	3	,	,	,
cord-262253-3ovqhypt	22	4	the	the	DT
cord-262253-3ovqhypt	22	5	buildup	buildup	NN
cord-262253-3ovqhypt	22	6	of	of	IN
cord-262253-3ovqhypt	22	7	extraneuronal	extraneuronal	JJ
cord-262253-3ovqhypt	22	8	amyloid	amyloid	NNP
cord-262253-3ovqhypt	22	9	-	-	HYPH
cord-262253-3ovqhypt	22	10	β	β	NN
cord-262253-3ovqhypt	22	11	(	(	-LRB-
cord-262253-3ovqhypt	22	12	Aβ	aβ	NN
cord-262253-3ovqhypt	22	13	)	)	-RRB-
cord-262253-3ovqhypt	22	14	plaques	plaque	NNS
cord-262253-3ovqhypt	22	15	became	become	VBD
cord-262253-3ovqhypt	22	16	the	the	DT
cord-262253-3ovqhypt	22	17	hallmark	hallmark	JJ
cord-262253-3ovqhypt	22	18	trait	trait	NN
cord-262253-3ovqhypt	22	19	of	of	IN
cord-262253-3ovqhypt	22	20	the	the	DT
cord-262253-3ovqhypt	22	21	pathogenesis	pathogenesis	NN
cord-262253-3ovqhypt	22	22	of	of	IN
cord-262253-3ovqhypt	22	23	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	22	24	's	's	POS
cord-262253-3ovqhypt	22	25	disease	disease	NN
cord-262253-3ovqhypt	22	26	[	[	-LRB-
cord-262253-3ovqhypt	22	27	3	3	CD
cord-262253-3ovqhypt	22	28	]	]	-RRB-
cord-262253-3ovqhypt	22	29	,	,	,
cord-262253-3ovqhypt	22	30	initiating	initiate	VBG
cord-262253-3ovqhypt	22	31	the	the	DT
cord-262253-3ovqhypt	22	32	development	development	NN
cord-262253-3ovqhypt	22	33	of	of	IN
cord-262253-3ovqhypt	22	34	the	the	DT
cord-262253-3ovqhypt	22	35	amyloid	amyloid	NN
cord-262253-3ovqhypt	22	36	cascade	cascade	NN
cord-262253-3ovqhypt	22	37	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	22	38	[	[	-LRB-
cord-262253-3ovqhypt	22	39	4	4	CD
cord-262253-3ovqhypt	22	40	]	]	-RRB-
cord-262253-3ovqhypt	22	41	.	.	.
cord-262253-3ovqhypt	23	1	In	in	IN
cord-262253-3ovqhypt	23	2	parallel	parallel	NN
cord-262253-3ovqhypt	23	3	to	to	IN
cord-262253-3ovqhypt	23	4	Aβ	Aβ	NNP
cord-262253-3ovqhypt	23	5	plaques	plaque	NNS
cord-262253-3ovqhypt	23	6	formation	formation	NN
cord-262253-3ovqhypt	23	7	,	,	,
cord-262253-3ovqhypt	23	8	the	the	DT
cord-262253-3ovqhypt	23	9	accumulation	accumulation	NN
cord-262253-3ovqhypt	23	10	of	of	IN
cord-262253-3ovqhypt	23	11	other	other	JJ
cord-262253-3ovqhypt	23	12	naturally	naturally	RB
cord-262253-3ovqhypt	23	13	unfolded	unfold	VBN
cord-262253-3ovqhypt	23	14	proteins	protein	NNS
cord-262253-3ovqhypt	23	15	is	be	VBZ
cord-262253-3ovqhypt	23	16	central	central	JJ
cord-262253-3ovqhypt	23	17	to	to	IN
cord-262253-3ovqhypt	23	18	AD	ad	NN
cord-262253-3ovqhypt	23	19	and	and	CC
cord-262253-3ovqhypt	23	20	other	other	JJ
cord-262253-3ovqhypt	23	21	cerebral	cerebral	JJ
cord-262253-3ovqhypt	23	22	proteopathies	proteopathie	NNS
cord-262253-3ovqhypt	23	23	[	[	-LRB-
cord-262253-3ovqhypt	23	24	5	5	CD
cord-262253-3ovqhypt	23	25	]	]	-RRB-
cord-262253-3ovqhypt	23	26	.	.	.
cord-262253-3ovqhypt	24	1	The	the	DT
cord-262253-3ovqhypt	24	2	intracellular	intracellular	JJ
cord-262253-3ovqhypt	24	3	aggregation	aggregation	NN
cord-262253-3ovqhypt	24	4	of	of	IN
cord-262253-3ovqhypt	24	5	tau	tau	NNP
cord-262253-3ovqhypt	24	6	proteins	protein	NNS
cord-262253-3ovqhypt	24	7	in	in	IN
cord-262253-3ovqhypt	24	8	the	the	DT
cord-262253-3ovqhypt	24	9	form	form	NN
cord-262253-3ovqhypt	24	10	of	of	IN
cord-262253-3ovqhypt	24	11	neurofibrillary	neurofibrillary	JJ
cord-262253-3ovqhypt	24	12	tangles	tangle	NNS
cord-262253-3ovqhypt	24	13	(	(	-LRB-
cord-262253-3ovqhypt	24	14	NFTs	NFTs	NNP
cord-262253-3ovqhypt	24	15	)	)	-RRB-
cord-262253-3ovqhypt	24	16	is	be	VBZ
cord-262253-3ovqhypt	24	17	also	also	RB
cord-262253-3ovqhypt	24	18	an	an	DT
cord-262253-3ovqhypt	24	19	essential	essential	JJ
cord-262253-3ovqhypt	24	20	trait	trait	NN
cord-262253-3ovqhypt	24	21	in	in	IN
cord-262253-3ovqhypt	24	22	the	the	DT
cord-262253-3ovqhypt	24	23	pathogenesis	pathogenesis	NN
cord-262253-3ovqhypt	24	24	of	of	IN
cord-262253-3ovqhypt	24	25	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	24	26	's	's	POS
cord-262253-3ovqhypt	24	27	disease	disease	NN
cord-262253-3ovqhypt	24	28	[	[	-LRB-
cord-262253-3ovqhypt	24	29	3	3	CD
cord-262253-3ovqhypt	24	30	,	,	,
cord-262253-3ovqhypt	24	31	6	6	CD
cord-262253-3ovqhypt	24	32	]	]	-RRB-
cord-262253-3ovqhypt	24	33	.	.	.
cord-262253-3ovqhypt	25	1	A	a	DT
cord-262253-3ovqhypt	25	2	recent	recent	JJ
cord-262253-3ovqhypt	25	3	2020	2020	CD
cord-262253-3ovqhypt	25	4	study	study	NN
cord-262253-3ovqhypt	25	5	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	25	6	's	's	POS
cord-262253-3ovqhypt	25	7	disease	disease	NN
cord-262253-3ovqhypt	25	8	[	[	-LRB-
cord-262253-3ovqhypt	25	9	3	3	CD
cord-262253-3ovqhypt	25	10	,	,	,
cord-262253-3ovqhypt	25	11	6	6	CD
cord-262253-3ovqhypt	25	12	]	]	-RRB-
cord-262253-3ovqhypt	25	13	.	.	.
cord-262253-3ovqhypt	26	1	A	a	DT
cord-262253-3ovqhypt	26	2	recent	recent	JJ
cord-262253-3ovqhypt	26	3	2020	2020	CD
cord-262253-3ovqhypt	26	4	study	study	NN
cord-262253-3ovqhypt	26	5	found	find	VBD
cord-262253-3ovqhypt	26	6	that	that	IN
cord-262253-3ovqhypt	26	7	neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	26	8	could	could	MD
cord-262253-3ovqhypt	26	9	play	play	VB
cord-262253-3ovqhypt	26	10	a	a	DT
cord-262253-3ovqhypt	26	11	role	role	NN
cord-262253-3ovqhypt	26	12	in	in	IN
cord-262253-3ovqhypt	26	13	the	the	DT
cord-262253-3ovqhypt	26	14	aggregation	aggregation	NN
cord-262253-3ovqhypt	26	15	of	of	IN
cord-262253-3ovqhypt	26	16	tau	tau	NNP
cord-262253-3ovqhypt	26	17	,	,	,
cord-262253-3ovqhypt	26	18	as	as	IN
cord-262253-3ovqhypt	26	19	DNA	DNA	NNP
cord-262253-3ovqhypt	26	20	extracted	extract	VBN
cord-262253-3ovqhypt	26	21	from	from	IN
cord-262253-3ovqhypt	26	22	various	various	JJ
cord-262253-3ovqhypt	26	23	bacterial	bacterial	JJ
cord-262253-3ovqhypt	26	24	species	specie	NNS
cord-262253-3ovqhypt	26	25	promoted	promote	VBN
cord-262253-3ovqhypt	26	26	tau	tau	NNP
cord-262253-3ovqhypt	26	27	misfolding	misfolde	VBG
cord-262253-3ovqhypt	26	28	[	[	-LRB-
cord-262253-3ovqhypt	26	29	7	7	CD
cord-262253-3ovqhypt	26	30	]	]	-RRB-
cord-262253-3ovqhypt	26	31	.	.	.
cord-262253-3ovqhypt	27	1	Whereas	whereas	IN
cord-262253-3ovqhypt	27	2	Aβ	Aβ	NNP
cord-262253-3ovqhypt	27	3	plaques	plaque	NNS
cord-262253-3ovqhypt	27	4	are	be	VBP
cord-262253-3ovqhypt	27	5	more	more	RBR
cord-262253-3ovqhypt	27	6	critical	critical	JJ
cord-262253-3ovqhypt	27	7	to	to	IN
cord-262253-3ovqhypt	27	8	AD	ad	NN
cord-262253-3ovqhypt	27	9	pathogenesis	pathogenesis	NN
cord-262253-3ovqhypt	27	10	,	,	,
cord-262253-3ovqhypt	27	11	the	the	DT
cord-262253-3ovqhypt	27	12	tau	tau	NNP
cord-262253-3ovqhypt	27	13	protein	protein	NN
cord-262253-3ovqhypt	27	14	appears	appear	VBZ
cord-262253-3ovqhypt	27	15	to	to	TO
cord-262253-3ovqhypt	27	16	be	be	VB
cord-262253-3ovqhypt	27	17	more	more	RBR
cord-262253-3ovqhypt	27	18	responsible	responsible	JJ
cord-262253-3ovqhypt	27	19	for	for	IN
cord-262253-3ovqhypt	27	20	subsequent	subsequent	JJ
cord-262253-3ovqhypt	27	21	cognitive	cognitive	JJ
cord-262253-3ovqhypt	27	22	impairment	impairment	NN
cord-262253-3ovqhypt	27	23	and	and	CC
cord-262253-3ovqhypt	27	24	dementia	dementia	NN
cord-262253-3ovqhypt	27	25	symptoms	symptom	NNS
cord-262253-3ovqhypt	27	26	associated	associate	VBN
cord-262253-3ovqhypt	27	27	with	with	IN
cord-262253-3ovqhypt	27	28	AD	ad	NN
cord-262253-3ovqhypt	27	29	[	[	-LRB-
cord-262253-3ovqhypt	27	30	8	8	CD
cord-262253-3ovqhypt	27	31	]	]	-RRB-
cord-262253-3ovqhypt	27	32	.	.	.
cord-262253-3ovqhypt	28	1	Indeed	indeed	RB
cord-262253-3ovqhypt	28	2	,	,	,
cord-262253-3ovqhypt	28	3	tau	tau	NNP
cord-262253-3ovqhypt	28	4	hyperphosphorylation	hyperphosphorylation	NNP
cord-262253-3ovqhypt	28	5	and	and	CC
cord-262253-3ovqhypt	28	6	NFT	NFT	NNP
cord-262253-3ovqhypt	28	7	levels	level	NNS
cord-262253-3ovqhypt	28	8	are	be	VBP
cord-262253-3ovqhypt	28	9	closely	closely	RB
cord-262253-3ovqhypt	28	10	correlated	correlate	VBN
cord-262253-3ovqhypt	28	11	with	with	IN
cord-262253-3ovqhypt	28	12	cognition	cognition	NN
cord-262253-3ovqhypt	28	13	,	,	,
cord-262253-3ovqhypt	28	14	and	and	CC
cord-262253-3ovqhypt	28	15	exhibit	exhibit	VB
cord-262253-3ovqhypt	28	16	potential	potential	NN
cord-262253-3ovqhypt	28	17	as	as	IN
cord-262253-3ovqhypt	28	18	therapeutic	therapeutic	JJ
cord-262253-3ovqhypt	28	19	targets	target	NNS
cord-262253-3ovqhypt	28	20	for	for	IN
cord-262253-3ovqhypt	28	21	AD	ad	NN
cord-262253-3ovqhypt	28	22	treatment	treatment	NN
cord-262253-3ovqhypt	28	23	[	[	-LRB-
cord-262253-3ovqhypt	28	24	9	9	CD
cord-262253-3ovqhypt	28	25	]	]	-RRB-
cord-262253-3ovqhypt	28	26	.	.	.
cord-262253-3ovqhypt	29	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	29	2	,	,	,
cord-262253-3ovqhypt	29	3	tau	tau	NN
cord-262253-3ovqhypt	29	4	protein	protein	NN
cord-262253-3ovqhypt	29	5	production	production	NN
cord-262253-3ovqhypt	29	6	has	have	VBZ
cord-262253-3ovqhypt	29	7	been	be	VBN
cord-262253-3ovqhypt	29	8	shown	show	VBN
cord-262253-3ovqhypt	29	9	to	to	TO
cord-262253-3ovqhypt	29	10	have	have	VB
cord-262253-3ovqhypt	29	11	a	a	DT
cord-262253-3ovqhypt	29	12	positive	positive	JJ
cord-262253-3ovqhypt	29	13	correlation	correlation	NN
cord-262253-3ovqhypt	29	14	with	with	IN
cord-262253-3ovqhypt	29	15	the	the	DT
cord-262253-3ovqhypt	29	16	production	production	NN
cord-262253-3ovqhypt	29	17	of	of	IN
cord-262253-3ovqhypt	29	18	Aβ	Aβ	NNP
cord-262253-3ovqhypt	29	19	plaques	plaque	NNS
cord-262253-3ovqhypt	29	20	[	[	-LRB-
cord-262253-3ovqhypt	29	21	10	10	CD
cord-262253-3ovqhypt	29	22	]	]	-RRB-
cord-262253-3ovqhypt	29	23	,	,	,
cord-262253-3ovqhypt	29	24	with	with	IN
cord-262253-3ovqhypt	29	25	the	the	DT
cord-262253-3ovqhypt	29	26	formation	formation	NN
cord-262253-3ovqhypt	29	27	and	and	CC
cord-262253-3ovqhypt	29	28	lack	lack	NN
cord-262253-3ovqhypt	29	29	of	of	IN
cord-262253-3ovqhypt	29	30	clearance	clearance	NN
cord-262253-3ovqhypt	29	31	of	of	IN
cord-262253-3ovqhypt	29	32	Aβ	Aβ	NNP
cord-262253-3ovqhypt	29	33	plaques	plaque	NNS
cord-262253-3ovqhypt	29	34	also	also	RB
cord-262253-3ovqhypt	29	35	being	be	VBG
cord-262253-3ovqhypt	29	36	proposed	propose	VBN
cord-262253-3ovqhypt	29	37	to	to	TO
cord-262253-3ovqhypt	29	38	induce	induce	VB
cord-262253-3ovqhypt	29	39	tau	tau	NNP
cord-262253-3ovqhypt	29	40	protein	protein	NN
cord-262253-3ovqhypt	29	41	formation	formation	NN
cord-262253-3ovqhypt	29	42	into	into	IN
cord-262253-3ovqhypt	29	43	NFTs	NFTs	NNPS
cord-262253-3ovqhypt	29	44	[	[	-LRB-
cord-262253-3ovqhypt	29	45	11	11	CD
cord-262253-3ovqhypt	29	46	]	]	-RRB-
cord-262253-3ovqhypt	29	47	.	.	.
cord-262253-3ovqhypt	30	1	Coupling	couple	VBG
cord-262253-3ovqhypt	30	2	this	this	DT
cord-262253-3ovqhypt	30	3	with	with	IN
cord-262253-3ovqhypt	30	4	the	the	DT
cord-262253-3ovqhypt	30	5	bi	bi	JJ
cord-262253-3ovqhypt	30	6	-	-	JJ
cord-262253-3ovqhypt	30	7	directional	directional	JJ
cord-262253-3ovqhypt	30	8	relationship	relationship	NN
cord-262253-3ovqhypt	30	9	between	between	IN
cord-262253-3ovqhypt	30	10	Aβ	Aβ	NNP
cord-262253-3ovqhypt	30	11	plaques	plaque	NNS
cord-262253-3ovqhypt	30	12	and	and	CC
cord-262253-3ovqhypt	30	13	neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	30	14	[	[	-LRB-
cord-262253-3ovqhypt	30	15	12	12	CD
cord-262253-3ovqhypt	30	16	]	]	-RRB-
cord-262253-3ovqhypt	30	17	would	would	MD
cord-262253-3ovqhypt	30	18	cement	cement	VB
cord-262253-3ovqhypt	30	19	Aβ	Aβ	NNP
cord-262253-3ovqhypt	30	20	's	's	POS
cord-262253-3ovqhypt	30	21	key	key	JJ
cord-262253-3ovqhypt	30	22	role	role	NN
cord-262253-3ovqhypt	30	23	in	in	IN
cord-262253-3ovqhypt	30	24	driving	drive	VBG
cord-262253-3ovqhypt	30	25	AD	ad	NN
cord-262253-3ovqhypt	30	26	pathology	pathology	NN
cord-262253-3ovqhypt	30	27	.	.	.
cord-262253-3ovqhypt	31	1	Aβ	aβ	NN
cord-262253-3ovqhypt	31	2	formation	formation	NN
cord-262253-3ovqhypt	31	3	begins	begin	VBZ
cord-262253-3ovqhypt	31	4	with	with	IN
cord-262253-3ovqhypt	31	5	the	the	DT
cord-262253-3ovqhypt	31	6	breakdown	breakdown	NN
cord-262253-3ovqhypt	31	7	of	of	IN
cord-262253-3ovqhypt	31	8	the	the	DT
cord-262253-3ovqhypt	31	9	amyloid	amyloid	NN
cord-262253-3ovqhypt	31	10	precursor	precursor	NN
cord-262253-3ovqhypt	31	11	proteins	protein	NNS
cord-262253-3ovqhypt	31	12	(	(	-LRB-
cord-262253-3ovqhypt	31	13	APP	app	NN
cord-262253-3ovqhypt	31	14	)	)	-RRB-
cord-262253-3ovqhypt	31	15	embedded	embed	VBN
cord-262253-3ovqhypt	31	16	in	in	IN
cord-262253-3ovqhypt	31	17	the	the	DT
cord-262253-3ovqhypt	31	18	membranes	membrane	NNS
cord-262253-3ovqhypt	31	19	of	of	IN
cord-262253-3ovqhypt	31	20	cells	cell	NNS
cord-262253-3ovqhypt	31	21	,	,	,
cord-262253-3ovqhypt	31	22	such	such	JJ
cord-262253-3ovqhypt	31	23	as	as	IN
cord-262253-3ovqhypt	31	24	neurons	neuron	NNS
cord-262253-3ovqhypt	31	25	,	,	,
cord-262253-3ovqhypt	31	26	as	as	IN
cord-262253-3ovqhypt	31	27	a	a	DT
cord-262253-3ovqhypt	31	28	type	type	NN
cord-262253-3ovqhypt	31	29	1	1	CD
cord-262253-3ovqhypt	31	30	transmembrane	transmembrane	NN
cord-262253-3ovqhypt	31	31	glycoprotein	glycoprotein	NN
cord-262253-3ovqhypt	31	32	[	[	-LRB-
cord-262253-3ovqhypt	31	33	13	13	CD
cord-262253-3ovqhypt	31	34	]	]	-RRB-
cord-262253-3ovqhypt	31	35	.	.	.
cord-262253-3ovqhypt	32	1	Aβ	Aβ	NNP
cord-262253-3ovqhypt	32	2	peptides	peptide	NNS
cord-262253-3ovqhypt	32	3	are	be	VBP
cord-262253-3ovqhypt	32	4	produced	produce	VBN
cord-262253-3ovqhypt	32	5	through	through	IN
cord-262253-3ovqhypt	32	6	a	a	DT
cord-262253-3ovqhypt	32	7	two	two	CD
cord-262253-3ovqhypt	32	8	-	-	HYPH
cord-262253-3ovqhypt	32	9	step	step	NN
cord-262253-3ovqhypt	32	10	cleavage	cleavage	NN
cord-262253-3ovqhypt	32	11	process	process	NN
cord-262253-3ovqhypt	32	12	,	,	,
cord-262253-3ovqhypt	32	13	in	in	IN
cord-262253-3ovqhypt	32	14	which	which	WDT
cord-262253-3ovqhypt	32	15	APP	app	NN
cord-262253-3ovqhypt	32	16	is	be	VBZ
cord-262253-3ovqhypt	32	17	metabolized	metabolize	VBN
cord-262253-3ovqhypt	32	18	into	into	IN
cord-262253-3ovqhypt	32	19	smaller	small	JJR
cord-262253-3ovqhypt	32	20	fragments	fragment	NNS
cord-262253-3ovqhypt	32	21	.	.	.
cord-262253-3ovqhypt	33	1	In	in	IN
cord-262253-3ovqhypt	33	2	the	the	DT
cord-262253-3ovqhypt	33	3	first	first	JJ
cord-262253-3ovqhypt	33	4	step	step	NN
cord-262253-3ovqhypt	33	5	,	,	,
cord-262253-3ovqhypt	33	6	APP	app	NN
cord-262253-3ovqhypt	33	7	is	be	VBZ
cord-262253-3ovqhypt	33	8	cleaved	cleave	VBN
cord-262253-3ovqhypt	33	9	by	by	IN
cord-262253-3ovqhypt	33	10	β	β	NNP
cord-262253-3ovqhypt	33	11	-	-	HYPH
cord-262253-3ovqhypt	33	12	secretase	secretase	NNP
cord-262253-3ovqhypt	33	13	1	1	CD
cord-262253-3ovqhypt	33	14	into	into	IN
cord-262253-3ovqhypt	33	15	a	a	DT
cord-262253-3ovqhypt	33	16	membrane	membrane	NN
cord-262253-3ovqhypt	33	17	-	-	HYPH
cord-262253-3ovqhypt	33	18	bound	bind	VBN
cord-262253-3ovqhypt	33	19	CTFβ	CTFβ	NNS
cord-262253-3ovqhypt	33	20	fragment	fragment	NN
cord-262253-3ovqhypt	33	21	(	(	-LRB-
cord-262253-3ovqhypt	33	22	containing	contain	VBG
cord-262253-3ovqhypt	33	23	99	99	CD
cord-262253-3ovqhypt	33	24	amino	amino	JJ
cord-262253-3ovqhypt	33	25	acids	acid	NNS
cord-262253-3ovqhypt	33	26	)	)	-RRB-
cord-262253-3ovqhypt	33	27	and	and	CC
cord-262253-3ovqhypt	33	28	an	an	DT
cord-262253-3ovqhypt	33	29	extracellular	extracellular	JJ
cord-262253-3ovqhypt	33	30	fragment	fragment	NN
cord-262253-3ovqhypt	33	31	sAPPβ	sAPPβ	NNS
cord-262253-3ovqhypt	33	32	.	.	.
cord-262253-3ovqhypt	34	1	CTFβ	CTFβ	NNS
cord-262253-3ovqhypt	34	2	is	be	VBZ
cord-262253-3ovqhypt	34	3	then	then	RB
cord-262253-3ovqhypt	34	4	further	further	RB
cord-262253-3ovqhypt	34	5	cleaved	cleave	VBN
cord-262253-3ovqhypt	34	6	by	by	IN
cord-262253-3ovqhypt	34	7	γsecretase	γsecretase	NNP
cord-262253-3ovqhypt	34	8	to	to	TO
cord-262253-3ovqhypt	34	9	create	create	VB
cord-262253-3ovqhypt	34	10	the	the	DT
cord-262253-3ovqhypt	34	11	final	final	JJ
cord-262253-3ovqhypt	34	12	Aβ	Aβ	NNP
cord-262253-3ovqhypt	34	13	peptide	peptide	NN
cord-262253-3ovqhypt	34	14	[	[	-LRB-
cord-262253-3ovqhypt	34	15	13	13	CD
cord-262253-3ovqhypt	34	16	]	]	-RRB-
cord-262253-3ovqhypt	34	17	[	[	-LRB-
cord-262253-3ovqhypt	34	18	14	14	CD
cord-262253-3ovqhypt	34	19	]	]	-RRB-
cord-262253-3ovqhypt	34	20	[	[	-LRB-
cord-262253-3ovqhypt	34	21	15	15	CD
cord-262253-3ovqhypt	34	22	]	]	-RRB-
cord-262253-3ovqhypt	34	23	,	,	,
cord-262253-3ovqhypt	34	24	as	as	IN
cord-262253-3ovqhypt	34	25	illustrated	illustrate	VBN
cord-262253-3ovqhypt	34	26	in	in	IN
cord-262253-3ovqhypt	34	27	Figure	Figure	NNP
cord-262253-3ovqhypt	34	28	1	1	CD
cord-262253-3ovqhypt	34	29	.	.	.
cord-262253-3ovqhypt	35	1	The	the	DT
cord-262253-3ovqhypt	35	2	length	length	NN
cord-262253-3ovqhypt	35	3	of	of	IN
cord-262253-3ovqhypt	35	4	Aβ	Aβ	NNP
cord-262253-3ovqhypt	35	5	peptides	peptide	NNS
cord-262253-3ovqhypt	35	6	is	be	VBZ
cord-262253-3ovqhypt	35	7	not	not	RB
cord-262253-3ovqhypt	35	8	fixed	fix	VBN
cord-262253-3ovqhypt	35	9	,	,	,
cord-262253-3ovqhypt	35	10	and	and	CC
cord-262253-3ovqhypt	35	11	can	can	MD
cord-262253-3ovqhypt	35	12	consist	consist	VB
cord-262253-3ovqhypt	35	13	of	of	IN
cord-262253-3ovqhypt	35	14	anywhere	anywhere	RB
cord-262253-3ovqhypt	35	15	between	between	IN
cord-262253-3ovqhypt	35	16	37	37	CD
cord-262253-3ovqhypt	35	17	and	and	CC
cord-262253-3ovqhypt	35	18	49	49	CD
cord-262253-3ovqhypt	35	19	amino	amino	JJ
cord-262253-3ovqhypt	35	20	acids	acid	NNS
cord-262253-3ovqhypt	35	21	,	,	,
cord-262253-3ovqhypt	35	22	depending	depend	VBG
cord-262253-3ovqhypt	35	23	on	on	IN
cord-262253-3ovqhypt	35	24	where	where	WRB
cord-262253-3ovqhypt	35	25	the	the	DT
cord-262253-3ovqhypt	35	26	cleavage	cleavage	NN
cord-262253-3ovqhypt	35	27	was	be	VBD
cord-262253-3ovqhypt	35	28	done	do	VBN
cord-262253-3ovqhypt	35	29	by	by	IN
cord-262253-3ovqhypt	35	30	β	β	NNP
cord-262253-3ovqhypt	35	31	-	-	HYPH
cord-262253-3ovqhypt	35	32	secretase	secretase	NNP
cord-262253-3ovqhypt	35	33	1	1	CD
cord-262253-3ovqhypt	35	34	and	and	CC
cord-262253-3ovqhypt	35	35	γ	γ	NNP
cord-262253-3ovqhypt	35	36	-	-	HYPH
cord-262253-3ovqhypt	35	37	secretase	secretase	NNP
cord-262253-3ovqhypt	35	38	[	[	-LRB-
cord-262253-3ovqhypt	35	39	16	16	CD
cord-262253-3ovqhypt	35	40	,	,	,
cord-262253-3ovqhypt	35	41	17	17	CD
cord-262253-3ovqhypt	35	42	]	]	-RRB-
cord-262253-3ovqhypt	35	43	.	.	.
cord-262253-3ovqhypt	36	1	The	the	DT
cord-262253-3ovqhypt	36	2	most	most	RBS
cord-262253-3ovqhypt	36	3	abundant	abundant	JJ
cord-262253-3ovqhypt	36	4	length	length	NN
cord-262253-3ovqhypt	36	5	is	be	VBZ
cord-262253-3ovqhypt	36	6	Aβ1	aβ1	CD
cord-262253-3ovqhypt	36	7	-40	-40	NNS
cord-262253-3ovqhypt	36	8	,	,	,
cord-262253-3ovqhypt	36	9	representing	represent	VBG
cord-262253-3ovqhypt	36	10	approximately	approximately	RB
cord-262253-3ovqhypt	36	11	80	80	CD
cord-262253-3ovqhypt	36	12	-	-	SYM
cord-262253-3ovqhypt	36	13	90	90	CD
cord-262253-3ovqhypt	36	14	%	%	NN
cord-262253-3ovqhypt	36	15	of	of	IN
cord-262253-3ovqhypt	36	16	Aβ	Aβ	NNP
cord-262253-3ovqhypt	36	17	peptides	peptide	NNS
cord-262253-3ovqhypt	36	18	,	,	,
cord-262253-3ovqhypt	36	19	whereas	whereas	IN
cord-262253-3ovqhypt	36	20	the	the	DT
cord-262253-3ovqhypt	36	21	least	least	JJS
cord-262253-3ovqhypt	36	22	soluble	soluble	JJ
cord-262253-3ovqhypt	36	23	of	of	IN
cord-262253-3ovqhypt	36	24	the	the	DT
cord-262253-3ovqhypt	36	25	Aβ	Aβ	NNP
cord-262253-3ovqhypt	36	26	peptides	peptide	NNS
cord-262253-3ovqhypt	36	27	,	,	,
cord-262253-3ovqhypt	36	28	Aβ1	aβ1	CD
cord-262253-3ovqhypt	36	29	-	-	SYM
cord-262253-3ovqhypt	36	30	42	42	CD
cord-262253-3ovqhypt	36	31	,	,	,
cord-262253-3ovqhypt	36	32	represents	represent	VBZ
cord-262253-3ovqhypt	36	33	roughly	roughly	RB
cord-262253-3ovqhypt	36	34	5	5	CD
cord-262253-3ovqhypt	36	35	-	-	SYM
cord-262253-3ovqhypt	36	36	10	10	CD
cord-262253-3ovqhypt	36	37	%	%	NN
cord-262253-3ovqhypt	36	38	[	[	-LRB-
cord-262253-3ovqhypt	36	39	13	13	CD
cord-262253-3ovqhypt	36	40	,	,	,
cord-262253-3ovqhypt	36	41	15	15	CD
cord-262253-3ovqhypt	36	42	]	]	-RRB-
cord-262253-3ovqhypt	36	43	.	.	.
cord-262253-3ovqhypt	37	1	As	as	IN
cord-262253-3ovqhypt	37	2	a	a	DT
cord-262253-3ovqhypt	37	3	greater	great	JJR
cord-262253-3ovqhypt	37	4	number	number	NN
cord-262253-3ovqhypt	37	5	of	of	IN
cord-262253-3ovqhypt	37	6	Aβ	Aβ	NNP
cord-262253-3ovqhypt	37	7	peptides	peptide	NNS
cord-262253-3ovqhypt	37	8	form	form	NN
cord-262253-3ovqhypt	37	9	,	,	,
cord-262253-3ovqhypt	37	10	they	-PRON-	PRP
cord-262253-3ovqhypt	37	11	begin	begin	VBP
cord-262253-3ovqhypt	37	12	to	to	TO
cord-262253-3ovqhypt	37	13	aggregate	aggregate	VB
cord-262253-3ovqhypt	37	14	into	into	IN
cord-262253-3ovqhypt	37	15	oligomers	oligomer	NNS
cord-262253-3ovqhypt	37	16	,	,	,
cord-262253-3ovqhypt	37	17	which	which	WDT
cord-262253-3ovqhypt	37	18	then	then	RB
cord-262253-3ovqhypt	37	19	form	form	VBP
cord-262253-3ovqhypt	37	20	fibrils	fibril	NNS
cord-262253-3ovqhypt	37	21	,	,	,
cord-262253-3ovqhypt	37	22	and	and	CC
cord-262253-3ovqhypt	37	23	eventually	eventually	RB
cord-262253-3ovqhypt	37	24	the	the	DT
cord-262253-3ovqhypt	37	25	insoluble	insoluble	JJ
cord-262253-3ovqhypt	37	26	plaques	plaque	NNS
cord-262253-3ovqhypt	37	27	characteristic	characteristic	JJ
cord-262253-3ovqhypt	37	28	of	of	IN
cord-262253-3ovqhypt	37	29	AD	ad	NN
cord-262253-3ovqhypt	37	30	[	[	-LRB-
cord-262253-3ovqhypt	37	31	13	13	CD
cord-262253-3ovqhypt	37	32	]	]	-RRB-
cord-262253-3ovqhypt	37	33	.	.	.
cord-262253-3ovqhypt	38	1	Of	of	IN
cord-262253-3ovqhypt	38	2	the	the	DT
cord-262253-3ovqhypt	38	3	different	different	JJ
cord-262253-3ovqhypt	38	4	isoforms	isoform	NNS
cord-262253-3ovqhypt	38	5	of	of	IN
cord-262253-3ovqhypt	38	6	Aβ	Aβ	NNP
cord-262253-3ovqhypt	38	7	peptides	peptide	NNS
cord-262253-3ovqhypt	38	8	,	,	,
cord-262253-3ovqhypt	38	9	Aβ1	aβ1	CD
cord-262253-3ovqhypt	38	10	-	-	SYM
cord-262253-3ovqhypt	38	11	40	40	CD
cord-262253-3ovqhypt	38	12	and	and	CC
cord-262253-3ovqhypt	38	13	Aβ1	aβ1	CD
cord-262253-3ovqhypt	38	14	-	-	SYM
cord-262253-3ovqhypt	38	15	42	42	CD
cord-262253-3ovqhypt	38	16	are	be	VBP
cord-262253-3ovqhypt	38	17	the	the	DT
cord-262253-3ovqhypt	38	18	most	most	RBS
cord-262253-3ovqhypt	38	19	common	common	JJ
cord-262253-3ovqhypt	38	20	in	in	IN
cord-262253-3ovqhypt	38	21	plaques	plaque	NNS
cord-262253-3ovqhypt	38	22	.	.	.
cord-262253-3ovqhypt	39	1	Regarding	regard	VBG
cord-262253-3ovqhypt	39	2	the	the	DT
cord-262253-3ovqhypt	39	3	comparative	comparative	JJ
cord-262253-3ovqhypt	39	4	role	role	NN
cord-262253-3ovqhypt	39	5	of	of	IN
cord-262253-3ovqhypt	39	6	Aβ1	aβ1	CD
cord-262253-3ovqhypt	39	7	-	-	SYM
cord-262253-3ovqhypt	39	8	40	40	CD
cord-262253-3ovqhypt	39	9	and	and	CC
cord-262253-3ovqhypt	39	10	Aβ1	aβ1	CD
cord-262253-3ovqhypt	39	11	-	-	SYM
cord-262253-3ovqhypt	39	12	42	42	CD
cord-262253-3ovqhypt	39	13	peptides	peptide	NNS
cord-262253-3ovqhypt	39	14	in	in	IN
cord-262253-3ovqhypt	39	15	the	the	DT
cord-262253-3ovqhypt	39	16	pathogenesis	pathogenesis	NN
cord-262253-3ovqhypt	39	17	of	of	IN
cord-262253-3ovqhypt	39	18	AD	ad	NN
cord-262253-3ovqhypt	39	19	,	,	,
cord-262253-3ovqhypt	39	20	Aβ1-	Aβ1-	NNP
cord-262253-3ovqhypt	39	21	42	42	CD
cord-262253-3ovqhypt	39	22	peptides	peptide	NNS
cord-262253-3ovqhypt	39	23	have	have	VBP
cord-262253-3ovqhypt	39	24	been	be	VBN
cord-262253-3ovqhypt	39	25	found	find	VBN
cord-262253-3ovqhypt	39	26	in	in	IN
cord-262253-3ovqhypt	39	27	higher	high	JJR
cord-262253-3ovqhypt	39	28	concentrations	concentration	NNS
cord-262253-3ovqhypt	39	29	in	in	IN
cord-262253-3ovqhypt	39	30	AD	ad	NN
cord-262253-3ovqhypt	39	31	.	.	.
cord-262253-3ovqhypt	40	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	40	2	,	,	,
cord-262253-3ovqhypt	40	3	Aβ1	aβ1	CD
cord-262253-3ovqhypt	40	4	-	-	SYM
cord-262253-3ovqhypt	40	5	42	42	CD
cord-262253-3ovqhypt	40	6	peptides	peptide	NNS
cord-262253-3ovqhypt	40	7	have	have	VBP
cord-262253-3ovqhypt	40	8	been	be	VBN
cord-262253-3ovqhypt	40	9	found	find	VBN
cord-262253-3ovqhypt	40	10	to	to	TO
cord-262253-3ovqhypt	40	11	be	be	VB
cord-262253-3ovqhypt	40	12	more	more	RBR
cord-262253-3ovqhypt	40	13	prone	prone	JJ
cord-262253-3ovqhypt	40	14	to	to	IN
cord-262253-3ovqhypt	40	15	forming	form	VBG
cord-262253-3ovqhypt	40	16	insoluble	insoluble	JJ
cord-262253-3ovqhypt	40	17	amyloid	amyloid	NN
cord-262253-3ovqhypt	40	18	fibrils	fibril	NNS
cord-262253-3ovqhypt	40	19	than	than	IN
cord-262253-3ovqhypt	40	20	Aβ1	aβ1	CD
cord-262253-3ovqhypt	40	21	-	-	HYPH
cord-262253-3ovqhypt	40	22	40	40	CD
cord-262253-3ovqhypt	40	23	[	[	-LRB-
cord-262253-3ovqhypt	40	24	18	18	CD
cord-262253-3ovqhypt	40	25	]	]	-RRB-
cord-262253-3ovqhypt	40	26	.	.	.
cord-262253-3ovqhypt	41	1	This	this	DT
cord-262253-3ovqhypt	41	2	is	be	VBZ
cord-262253-3ovqhypt	41	3	further	further	RB
cord-262253-3ovqhypt	41	4	supported	support	VBN
cord-262253-3ovqhypt	41	5	by	by	IN
cord-262253-3ovqhypt	41	6	a	a	DT
cord-262253-3ovqhypt	41	7	study	study	NN
cord-262253-3ovqhypt	41	8	using	use	VBG
cord-262253-3ovqhypt	41	9	transgenic	transgenic	JJ
cord-262253-3ovqhypt	41	10	mice	mouse	NNS
cord-262253-3ovqhypt	41	11	that	that	WDT
cord-262253-3ovqhypt	41	12	expressed	express	VBD
cord-262253-3ovqhypt	41	13	either	either	DT
cord-262253-3ovqhypt	41	14	Aβ1	aβ1	CD
cord-262253-3ovqhypt	41	15	-	-	SYM
cord-262253-3ovqhypt	41	16	40	40	CD
cord-262253-3ovqhypt	41	17	(	(	-LRB-
cord-262253-3ovqhypt	41	18	BRI	BRI	NNP
cord-262253-3ovqhypt	41	19	-	-	HYPH
cord-262253-3ovqhypt	41	20	Aβ40	Aβ40	NNP
cord-262253-3ovqhypt	41	21	)	)	-RRB-
cord-262253-3ovqhypt	41	22	or	or	CC
cord-262253-3ovqhypt	41	23	Aβ1	aβ1	CD
cord-262253-3ovqhypt	41	24	-	-	SYM
cord-262253-3ovqhypt	41	25	42	42	CD
cord-262253-3ovqhypt	41	26	(	(	-LRB-
cord-262253-3ovqhypt	41	27	BRI	BRI	NNP
cord-262253-3ovqhypt	41	28	-	-	HYPH
cord-262253-3ovqhypt	41	29	Aβ42A	Aβ42A	NNP
cord-262253-3ovqhypt	41	30	)	)	-RRB-
cord-262253-3ovqhypt	41	31	.	.	.
cord-262253-3ovqhypt	42	1	The	the	DT
cord-262253-3ovqhypt	42	2	authors	author	NNS
cord-262253-3ovqhypt	42	3	found	find	VBD
cord-262253-3ovqhypt	42	4	that	that	IN
cord-262253-3ovqhypt	42	5	the	the	DT
cord-262253-3ovqhypt	42	6	mice	mouse	NNS
cord-262253-3ovqhypt	42	7	that	that	WDT
cord-262253-3ovqhypt	42	8	selectively	selectively	RB
cord-262253-3ovqhypt	42	9	expressed	express	VBD
cord-262253-3ovqhypt	42	10	Aβ1	aβ1	CD
cord-262253-3ovqhypt	42	11	-	-	SYM
cord-262253-3ovqhypt	42	12	40	40	CD
cord-262253-3ovqhypt	42	13	did	do	VBD
cord-262253-3ovqhypt	42	14	not	not	RB
cord-262253-3ovqhypt	42	15	develop	develop	VB
cord-262253-3ovqhypt	42	16	AD	ad	NN
cord-262253-3ovqhypt	42	17	pathology	pathology	NN
cord-262253-3ovqhypt	42	18	at	at	IN
cord-262253-3ovqhypt	42	19	any	any	DT
cord-262253-3ovqhypt	42	20	age	age	NN
cord-262253-3ovqhypt	42	21	.	.	.
cord-262253-3ovqhypt	43	1	However	however	RB
cord-262253-3ovqhypt	43	2	,	,	,
cord-262253-3ovqhypt	43	3	the	the	DT
cord-262253-3ovqhypt	43	4	same	same	JJ
cord-262253-3ovqhypt	43	5	did	do	VBD
cord-262253-3ovqhypt	43	6	not	not	RB
cord-262253-3ovqhypt	43	7	hold	hold	VB
cord-262253-3ovqhypt	43	8	true	true	JJ
cord-262253-3ovqhypt	43	9	for	for	IN
cord-262253-3ovqhypt	43	10	BRI	BRI	NNP
cord-262253-3ovqhypt	43	11	-	-	HYPH
cord-262253-3ovqhypt	43	12	Aβ42A	aβ42a	NN
cord-262253-3ovqhypt	43	13	mice	mouse	NNS
cord-262253-3ovqhypt	43	14	,	,	,
cord-262253-3ovqhypt	43	15	which	which	WDT
cord-262253-3ovqhypt	43	16	had	have	VBD
cord-262253-3ovqhypt	43	17	developed	develop	VBN
cord-262253-3ovqhypt	43	18	Aβ	Aβ	NNP
cord-262253-3ovqhypt	43	19	deposits	deposit	NNS
cord-262253-3ovqhypt	43	20	[	[	-LRB-
cord-262253-3ovqhypt	43	21	19	19	CD
cord-262253-3ovqhypt	43	22	]	]	-RRB-
cord-262253-3ovqhypt	43	23	.	.	.
cord-262253-3ovqhypt	44	1	In	in	IN
cord-262253-3ovqhypt	44	2	addition	addition	NN
cord-262253-3ovqhypt	44	3	,	,	,
cord-262253-3ovqhypt	44	4	another	another	DT
cord-262253-3ovqhypt	44	5	study	study	NN
cord-262253-3ovqhypt	44	6	found	find	VBD
cord-262253-3ovqhypt	44	7	Aβ1	aβ1	CD
cord-262253-3ovqhypt	44	8	-	-	SYM
cord-262253-3ovqhypt	44	9	42	42	CD
cord-262253-3ovqhypt	44	10	peptides	peptide	NNS
cord-262253-3ovqhypt	44	11	to	to	TO
cord-262253-3ovqhypt	44	12	promote	promote	VB
cord-262253-3ovqhypt	44	13	Aβ	Aβ	NNP
cord-262253-3ovqhypt	44	14	plaques	plaque	NNS
cord-262253-3ovqhypt	44	15	formation	formation	NN
cord-262253-3ovqhypt	44	16	,	,	,
cord-262253-3ovqhypt	44	17	and	and	CC
cord-262253-3ovqhypt	44	18	Aβ1	aβ1	CD
cord-262253-3ovqhypt	44	19	-	-	SYM
cord-262253-3ovqhypt	44	20	40	40	CD
cord-262253-3ovqhypt	44	21	to	to	TO
cord-262253-3ovqhypt	44	22	decrease	decrease	VB
cord-262253-3ovqhypt	44	23	Aβ	Aβ	NNP
cord-262253-3ovqhypt	44	24	deposition	deposition	NN
cord-262253-3ovqhypt	44	25	[	[	-LRB-
cord-262253-3ovqhypt	44	26	20	20	CD
cord-262253-3ovqhypt	44	27	]	]	-RRB-
cord-262253-3ovqhypt	44	28	.	.	.
cord-262253-3ovqhypt	45	1	These	these	DT
cord-262253-3ovqhypt	45	2	findings	finding	NNS
cord-262253-3ovqhypt	45	3	would	would	MD
cord-262253-3ovqhypt	45	4	indicate	indicate	VB
cord-262253-3ovqhypt	45	5	the	the	DT
cord-262253-3ovqhypt	45	6	key	key	JJ
cord-262253-3ovqhypt	45	7	role	role	NN
cord-262253-3ovqhypt	45	8	Aβ1	aβ1	CD
cord-262253-3ovqhypt	45	9	-	-	SYM
cord-262253-3ovqhypt	45	10	42	42	CD
cord-262253-3ovqhypt	45	11	peptides	peptide	NNS
cord-262253-3ovqhypt	45	12	play	play	VBP
cord-262253-3ovqhypt	45	13	in	in	IN
cord-262253-3ovqhypt	45	14	the	the	DT
cord-262253-3ovqhypt	45	15	pathogenesis	pathogenesis	NN
cord-262253-3ovqhypt	45	16	of	of	IN
cord-262253-3ovqhypt	45	17	AD	ad	NN
cord-262253-3ovqhypt	45	18	.	.	.
cord-262253-3ovqhypt	45	19	 	 	_SP
cord-262253-3ovqhypt	46	1	Even	even	RB
cord-262253-3ovqhypt	46	2	with	with	IN
cord-262253-3ovqhypt	46	3	the	the	DT
cord-262253-3ovqhypt	46	4	tremendous	tremendous	JJ
cord-262253-3ovqhypt	46	5	effort	effort	NN
cord-262253-3ovqhypt	46	6	that	that	WDT
cord-262253-3ovqhypt	46	7	has	have	VBZ
cord-262253-3ovqhypt	46	8	been	be	VBN
cord-262253-3ovqhypt	46	9	put	put	VBN
cord-262253-3ovqhypt	46	10	into	into	IN
cord-262253-3ovqhypt	46	11	developing	develop	VBG
cord-262253-3ovqhypt	46	12	potential	potential	JJ
cord-262253-3ovqhypt	46	13	therapies	therapy	NNS
cord-262253-3ovqhypt	46	14	for	for	IN
cord-262253-3ovqhypt	46	15	AD	ad	NN
cord-262253-3ovqhypt	46	16	over	over	IN
cord-262253-3ovqhypt	46	17	the	the	DT
cord-262253-3ovqhypt	46	18	past	past	JJ
cord-262253-3ovqhypt	46	19	few	few	JJ
cord-262253-3ovqhypt	46	20	decades	decade	NNS
cord-262253-3ovqhypt	46	21	,	,	,
cord-262253-3ovqhypt	46	22	there	there	EX
cord-262253-3ovqhypt	46	23	has	have	VBZ
cord-262253-3ovqhypt	46	24	been	be	VBN
cord-262253-3ovqhypt	46	25	little	little	JJ
cord-262253-3ovqhypt	46	26	success	success	NN
cord-262253-3ovqhypt	46	27	in	in	IN
cord-262253-3ovqhypt	46	28	reaching	reach	VBG
cord-262253-3ovqhypt	46	29	an	an	DT
cord-262253-3ovqhypt	46	30	effective	effective	JJ
cord-262253-3ovqhypt	46	31	therapy	therapy	NN
cord-262253-3ovqhypt	46	32	,	,	,
cord-262253-3ovqhypt	46	33	with	with	IN
cord-262253-3ovqhypt	46	34	no	no	DT
cord-262253-3ovqhypt	46	35	new	new	JJ
cord-262253-3ovqhypt	46	36	drug	drug	NN
cord-262253-3ovqhypt	46	37	being	be	VBG
cord-262253-3ovqhypt	46	38	approved	approve	VBN
cord-262253-3ovqhypt	46	39	in	in	RB
cord-262253-3ovqhypt	46	40	over	over	IN
cord-262253-3ovqhypt	46	41	a	a	DT
cord-262253-3ovqhypt	46	42	decade	decade	NN
cord-262253-3ovqhypt	46	43	.	.	.
cord-262253-3ovqhypt	47	1	While	while	IN
cord-262253-3ovqhypt	47	2	cholinesterase	cholinesterase	NN
cord-262253-3ovqhypt	47	3	inhibitors	inhibitor	NNS
cord-262253-3ovqhypt	47	4	and	and	CC
cord-262253-3ovqhypt	47	5	memantine	memantine	NN
cord-262253-3ovqhypt	47	6	are	be	VBP
cord-262253-3ovqhypt	47	7	FDA	FDA	NNP
cord-262253-3ovqhypt	47	8	-	-	HYPH
cord-262253-3ovqhypt	47	9	approved	approve	VBN
cord-262253-3ovqhypt	47	10	drugs	drug	NNS
cord-262253-3ovqhypt	47	11	for	for	IN
cord-262253-3ovqhypt	47	12	AD	ad	NN
cord-262253-3ovqhypt	47	13	,	,	,
cord-262253-3ovqhypt	47	14	and	and	CC
cord-262253-3ovqhypt	47	15	do	do	VB
cord-262253-3ovqhypt	47	16	address	address	VB
cord-262253-3ovqhypt	47	17	some	some	DT
cord-262253-3ovqhypt	47	18	of	of	IN
cord-262253-3ovqhypt	47	19	its	-PRON-	PRP$
cord-262253-3ovqhypt	47	20	symptoms	symptom	NNS
cord-262253-3ovqhypt	47	21	,	,	,
cord-262253-3ovqhypt	47	22	they	-PRON-	PRP
cord-262253-3ovqhypt	47	23	lack	lack	VBP
cord-262253-3ovqhypt	47	24	the	the	DT
cord-262253-3ovqhypt	47	25	ability	ability	NN
cord-262253-3ovqhypt	47	26	to	to	TO
cord-262253-3ovqhypt	47	27	attenuate	attenuate	VB
cord-262253-3ovqhypt	47	28	disease	disease	NN
cord-262253-3ovqhypt	47	29	progression	progression	NN
cord-262253-3ovqhypt	47	30	.	.	.
cord-262253-3ovqhypt	48	1	Over	over	IN
cord-262253-3ovqhypt	48	2	the	the	DT
cord-262253-3ovqhypt	48	3	past	past	JJ
cord-262253-3ovqhypt	48	4	20	20	CD
cord-262253-3ovqhypt	48	5	years	year	NNS
cord-262253-3ovqhypt	48	6	,	,	,
cord-262253-3ovqhypt	48	7	a	a	DT
cord-262253-3ovqhypt	48	8	majority	majority	NN
cord-262253-3ovqhypt	48	9	of	of	IN
cord-262253-3ovqhypt	48	10	the	the	DT
cord-262253-3ovqhypt	48	11	therapies	therapy	NNS
cord-262253-3ovqhypt	48	12	have	have	VBP
cord-262253-3ovqhypt	48	13	been	be	VBN
cord-262253-3ovqhypt	48	14	based	base	VBN
cord-262253-3ovqhypt	48	15	on	on	IN
cord-262253-3ovqhypt	48	16	the	the	DT
cord-262253-3ovqhypt	48	17	amyloid	amyloid	NN
cord-262253-3ovqhypt	48	18	cascade	cascade	NN
cord-262253-3ovqhypt	48	19	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	48	20	,	,	,
cord-262253-3ovqhypt	48	21	and	and	CC
cord-262253-3ovqhypt	48	22	hence	hence	RB
cord-262253-3ovqhypt	48	23	have	have	VBP
cord-262253-3ovqhypt	48	24	focused	focus	VBN
cord-262253-3ovqhypt	48	25	on	on	IN
cord-262253-3ovqhypt	48	26	depleting	deplete	VBG
cord-262253-3ovqhypt	48	27	Aβ	Aβ	NNP
cord-262253-3ovqhypt	48	28	peptides	peptide	NNS
cord-262253-3ovqhypt	48	29	.	.	.
cord-262253-3ovqhypt	49	1	These	these	DT
cord-262253-3ovqhypt	49	2	s	s	POS
cord-262253-3ovqhypt	49	3	therapies	therapy	NNS
cord-262253-3ovqhypt	49	4	often	often	RB
cord-262253-3ovqhypt	49	5	aim	aim	VBP
cord-262253-3ovqhypt	49	6	to	to	TO
cord-262253-3ovqhypt	49	7	inhibit	inhibit	VB
cord-262253-3ovqhypt	49	8	γ	γ	NN
cord-262253-3ovqhypt	49	9	-	-	HYPH
cord-262253-3ovqhypt	49	10	secretase	secretase	NNP
cord-262253-3ovqhypt	49	11	or	or	CC
cord-262253-3ovqhypt	49	12	β	β	NNP
cord-262253-3ovqhypt	49	13	-	-	HYPH
cord-262253-3ovqhypt	49	14	secretase	secretase	JJ
cord-262253-3ovqhypt	49	15	activity	activity	NN
cord-262253-3ovqhypt	49	16	in	in	IN
cord-262253-3ovqhypt	49	17	order	order	NN
cord-262253-3ovqhypt	49	18	to	to	TO
cord-262253-3ovqhypt	49	19	limit	limit	VB
cord-262253-3ovqhypt	49	20	Aβ	Aβ	NNP
cord-262253-3ovqhypt	49	21	peptide	peptide	JJ
cord-262253-3ovqhypt	49	22	production	production	NN
cord-262253-3ovqhypt	49	23	.	.	.
cord-262253-3ovqhypt	50	1	Therapies	therapy	NNS
cord-262253-3ovqhypt	50	2	that	that	WDT
cord-262253-3ovqhypt	50	3	use	use	VBP
cord-262253-3ovqhypt	50	4	such	such	JJ
cord-262253-3ovqhypt	50	5	methods	method	NNS
cord-262253-3ovqhypt	50	6	have	have	VBP
cord-262253-3ovqhypt	50	7	,	,	,
cord-262253-3ovqhypt	50	8	however	however	RB
cord-262253-3ovqhypt	50	9	,	,	,
cord-262253-3ovqhypt	50	10	seen	see	VBN
cord-262253-3ovqhypt	50	11	an	an	DT
cord-262253-3ovqhypt	50	12	increase	increase	NN
cord-262253-3ovqhypt	50	13	in	in	IN
cord-262253-3ovqhypt	50	14	the	the	DT
cord-262253-3ovqhypt	50	15	rate	rate	NN
cord-262253-3ovqhypt	50	16	of	of	IN
cord-262253-3ovqhypt	50	17	infection	infection	NN
cord-262253-3ovqhypt	50	18	during	during	IN
cord-262253-3ovqhypt	50	19	clinical	clinical	JJ
cord-262253-3ovqhypt	50	20	studies	study	NNS
cord-262253-3ovqhypt	50	21	,	,	,
cord-262253-3ovqhypt	50	22	with	with	IN
cord-262253-3ovqhypt	50	23	one	one	CD
cord-262253-3ovqhypt	50	24	study	study	NN
cord-262253-3ovqhypt	50	25	seeing	see	VBG
cord-262253-3ovqhypt	50	26	6	6	CD
cord-262253-3ovqhypt	50	27	%	%	NN
cord-262253-3ovqhypt	50	28	of	of	IN
cord-262253-3ovqhypt	50	29	participants	participant	NNS
cord-262253-3ovqhypt	50	30	develop	develop	VBP
cord-262253-3ovqhypt	50	31	meningoencephalitis	meningoencephalitis	NNP
cord-262253-3ovqhypt	50	32	[	[	-LRB-
cord-262253-3ovqhypt	50	33	21	21	CD
cord-262253-3ovqhypt	50	34	,	,	,
cord-262253-3ovqhypt	50	35	22	22	CD
cord-262253-3ovqhypt	50	36	]	]	-RRB-
cord-262253-3ovqhypt	50	37	.	.	.
cord-262253-3ovqhypt	51	1	Tarenflurbil	Tarenflurbil	NNP
cord-262253-3ovqhypt	51	2	,	,	,
cord-262253-3ovqhypt	51	3	for	for	IN
cord-262253-3ovqhypt	51	4	instance	instance	NN
cord-262253-3ovqhypt	51	5	,	,	,
cord-262253-3ovqhypt	51	6	had	have	VBD
cord-262253-3ovqhypt	51	7	been	be	VBN
cord-262253-3ovqhypt	51	8	administered	administer	VBN
cord-262253-3ovqhypt	51	9	clinically	clinically	RB
cord-262253-3ovqhypt	51	10	,	,	,
cord-262253-3ovqhypt	51	11	after	after	IN
cord-262253-3ovqhypt	51	12	it	-PRON-	PRP
cord-262253-3ovqhypt	51	13	was	be	VBD
cord-262253-3ovqhypt	51	14	shown	show	VBN
cord-262253-3ovqhypt	51	15	to	to	TO
cord-262253-3ovqhypt	51	16	modulate	modulate	VB
cord-262253-3ovqhypt	51	17	γ	γ	NN
cord-262253-3ovqhypt	51	18	-	-	HYPH
cord-262253-3ovqhypt	51	19	secretase	secretase	NN
cord-262253-3ovqhypt	51	20	and	and	CC
cord-262253-3ovqhypt	51	21	increase	increase	VB
cord-262253-3ovqhypt	51	22	production	production	NN
cord-262253-3ovqhypt	51	23	of	of	IN
cord-262253-3ovqhypt	51	24	the	the	DT
cord-262253-3ovqhypt	51	25	less	less	RBR
cord-262253-3ovqhypt	51	26	toxic	toxic	JJ
cord-262253-3ovqhypt	51	27	Aβ	Aβ	NNP
cord-262253-3ovqhypt	51	28	1	1	CD
cord-262253-3ovqhypt	51	29	-	-	SYM
cord-262253-3ovqhypt	51	30	38	38	CD
cord-262253-3ovqhypt	51	31	peptide	peptide	NN
cord-262253-3ovqhypt	51	32	,	,	,
cord-262253-3ovqhypt	51	33	rather	rather	RB
cord-262253-3ovqhypt	51	34	than	than	IN
cord-262253-3ovqhypt	51	35	Aβ	Aβ	NNP
cord-262253-3ovqhypt	51	36	1	1	CD
cord-262253-3ovqhypt	51	37	-	-	SYM
cord-262253-3ovqhypt	51	38	42	42	CD
cord-262253-3ovqhypt	51	39	peptide	peptide	NN
cord-262253-3ovqhypt	51	40	[	[	-LRB-
cord-262253-3ovqhypt	51	41	23	23	CD
cord-262253-3ovqhypt	51	42	,	,	,
cord-262253-3ovqhypt	51	43	24	24	CD
cord-262253-3ovqhypt	51	44	]	]	-RRB-
cord-262253-3ovqhypt	51	45	.	.	.
cord-262253-3ovqhypt	52	1	However	however	RB
cord-262253-3ovqhypt	52	2	,	,	,
cord-262253-3ovqhypt	52	3	in	in	IN
cord-262253-3ovqhypt	52	4	addition	addition	NN
cord-262253-3ovqhypt	52	5	to	to	IN
cord-262253-3ovqhypt	52	6	not	not	RB
cord-262253-3ovqhypt	52	7	showing	show	VBG
cord-262253-3ovqhypt	52	8	any	any	DT
cord-262253-3ovqhypt	52	9	significant	significant	JJ
cord-262253-3ovqhypt	52	10	benefit	benefit	NN
cord-262253-3ovqhypt	52	11	in	in	IN
cord-262253-3ovqhypt	52	12	individuals	individual	NNS
cord-262253-3ovqhypt	52	13	with	with	IN
cord-262253-3ovqhypt	52	14	mild	mild	JJ
cord-262253-3ovqhypt	52	15	AD	ad	NN
cord-262253-3ovqhypt	52	16	,	,	,
cord-262253-3ovqhypt	52	17	participants	participant	NNS
cord-262253-3ovqhypt	52	18	in	in	IN
cord-262253-3ovqhypt	52	19	the	the	DT
cord-262253-3ovqhypt	52	20	treatment	treatment	NN
cord-262253-3ovqhypt	52	21	group	group	NN
cord-262253-3ovqhypt	52	22	experienced	experience	VBD
cord-262253-3ovqhypt	52	23	an	an	DT
cord-262253-3ovqhypt	52	24	increase	increase	NN
cord-262253-3ovqhypt	52	25	in	in	IN
cord-262253-3ovqhypt	52	26	upper	upper	JJ
cord-262253-3ovqhypt	52	27	respiratory	respiratory	JJ
cord-262253-3ovqhypt	52	28	infections	infection	NNS
cord-262253-3ovqhypt	52	29	and	and	CC
cord-262253-3ovqhypt	52	30	dizziness	dizziness	NN
cord-262253-3ovqhypt	52	31	compared	compare	VBN
cord-262253-3ovqhypt	52	32	to	to	IN
cord-262253-3ovqhypt	52	33	the	the	DT
cord-262253-3ovqhypt	52	34	placebo	placebo	NN
cord-262253-3ovqhypt	52	35	group	group	NN
cord-262253-3ovqhypt	52	36	[	[	-LRB-
cord-262253-3ovqhypt	52	37	25	25	CD
cord-262253-3ovqhypt	52	38	]	]	-RRB-
cord-262253-3ovqhypt	52	39	.	.	.
cord-262253-3ovqhypt	53	1	Additionally	additionally	RB
cord-262253-3ovqhypt	53	2	,	,	,
cord-262253-3ovqhypt	53	3	in	in	IN
cord-262253-3ovqhypt	53	4	the	the	DT
cord-262253-3ovqhypt	53	5	time	time	NN
cord-262253-3ovqhypt	53	6	of	of	IN
cord-262253-3ovqhypt	53	7	COVID-19	covid-19	JJ
cord-262253-3ovqhypt	53	8	infection	infection	NN
cord-262253-3ovqhypt	53	9	,	,	,
cord-262253-3ovqhypt	53	10	respiratory	respiratory	NN
cord-262253-3ovqhypt	53	11	-	-	HYPH
cord-262253-3ovqhypt	53	12	related	relate	VBN
cord-262253-3ovqhypt	53	13	side	side	NN
cord-262253-3ovqhypt	53	14	effects	effect	NNS
cord-262253-3ovqhypt	53	15	,	,	,
cord-262253-3ovqhypt	53	16	such	such	JJ
cord-262253-3ovqhypt	53	17	as	as	IN
cord-262253-3ovqhypt	53	18	the	the	DT
cord-262253-3ovqhypt	53	19	ones	one	NNS
cord-262253-3ovqhypt	53	20	related	relate	VBN
cord-262253-3ovqhypt	53	21	to	to	IN
cord-262253-3ovqhypt	53	22	tarenflurbil	tarenflurbil	NNP
cord-262253-3ovqhypt	53	23	,	,	,
cord-262253-3ovqhypt	53	24	are	be	VBP
cord-262253-3ovqhypt	53	25	of	of	IN
cord-262253-3ovqhypt	53	26	growing	grow	VBG
cord-262253-3ovqhypt	53	27	concern	concern	NN
cord-262253-3ovqhypt	53	28	.	.	.
cord-262253-3ovqhypt	54	1	The	the	DT
cord-262253-3ovqhypt	54	2	γ	γ	NN
cord-262253-3ovqhypt	54	3	-	-	HYPH
cord-262253-3ovqhypt	54	4	secretase	secretase	JJ
cord-262253-3ovqhypt	54	5	inhibitor	inhibitor	NN
cord-262253-3ovqhypt	54	6	Semagacestat	Semagacestat	NNP
cord-262253-3ovqhypt	54	7	has	have	VBZ
cord-262253-3ovqhypt	54	8	not	not	RB
cord-262253-3ovqhypt	54	9	only	only	RB
cord-262253-3ovqhypt	54	10	been	be	VBN
cord-262253-3ovqhypt	54	11	associated	associate	VBN
cord-262253-3ovqhypt	54	12	with	with	IN
cord-262253-3ovqhypt	54	13	increased	increase	VBN
cord-262253-3ovqhypt	54	14	levels	level	NNS
cord-262253-3ovqhypt	54	15	of	of	IN
cord-262253-3ovqhypt	54	16	infection	infection	NN
cord-262253-3ovqhypt	54	17	,	,	,
cord-262253-3ovqhypt	54	18	but	but	CC
cord-262253-3ovqhypt	54	19	also	also	RB
cord-262253-3ovqhypt	54	20	with	with	IN
cord-262253-3ovqhypt	54	21	a	a	DT
cord-262253-3ovqhypt	54	22	failure	failure	NN
cord-262253-3ovqhypt	54	23	to	to	TO
cord-262253-3ovqhypt	54	24	provide	provide	VB
cord-262253-3ovqhypt	54	25	any	any	DT
cord-262253-3ovqhypt	54	26	cognitive	cognitive	JJ
cord-262253-3ovqhypt	54	27	improvement	improvement	NN
cord-262253-3ovqhypt	54	28	in	in	IN
cord-262253-3ovqhypt	54	29	patients	patient	NNS
cord-262253-3ovqhypt	54	30	with	with	IN
cord-262253-3ovqhypt	54	31	probable	probable	JJ
cord-262253-3ovqhypt	54	32	AD	ad	NN
cord-262253-3ovqhypt	54	33	[	[	-LRB-
cord-262253-3ovqhypt	54	34	26	26	CD
cord-262253-3ovqhypt	54	35	]	]	-RRB-
cord-262253-3ovqhypt	54	36	.	.	.
cord-262253-3ovqhypt	55	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	55	2	,	,	,
cord-262253-3ovqhypt	55	3	when	when	WRB
cord-262253-3ovqhypt	55	4	patients	patient	NNS
cord-262253-3ovqhypt	55	5	with	with	IN
cord-262253-3ovqhypt	55	6	mild	mild	JJ
cord-262253-3ovqhypt	55	7	to	to	IN
cord-262253-3ovqhypt	55	8	moderate	moderate	JJ
cord-262253-3ovqhypt	55	9	AD	ad	NN
cord-262253-3ovqhypt	55	10	were	be	VBD
cord-262253-3ovqhypt	55	11	administered	administer	VBN
cord-262253-3ovqhypt	55	12	ELND005	ELND005	NNP
cord-262253-3ovqhypt	55	13	,	,	,
cord-262253-3ovqhypt	55	14	a	a	DT
cord-262253-3ovqhypt	55	15	compound	compound	NN
cord-262253-3ovqhypt	55	16	that	that	WDT
cord-262253-3ovqhypt	55	17	inhibits	inhibit	VBZ
cord-262253-3ovqhypt	55	18	Aβ	Aβ	NNP
cord-262253-3ovqhypt	55	19	fibrils	fibril	NNS
cord-262253-3ovqhypt	55	20	and	and	CC
cord-262253-3ovqhypt	55	21	plaque	plaque	NN
cord-262253-3ovqhypt	55	22	formation	formation	NN
cord-262253-3ovqhypt	55	23	,	,	,
cord-262253-3ovqhypt	55	24	it	-PRON-	PRP
cord-262253-3ovqhypt	55	25	was	be	VBD
cord-262253-3ovqhypt	55	26	observed	observe	VBN
cord-262253-3ovqhypt	55	27	that	that	IN
cord-262253-3ovqhypt	55	28	higher	high	JJR
cord-262253-3ovqhypt	55	29	doses	dose	NNS
cord-262253-3ovqhypt	55	30	of	of	IN
cord-262253-3ovqhypt	55	31	this	this	DT
cord-262253-3ovqhypt	55	32	treatment	treatment	NN
cord-262253-3ovqhypt	55	33	led	lead	VBD
cord-262253-3ovqhypt	55	34	to	to	IN
cord-262253-3ovqhypt	55	35	serious	serious	JJ
cord-262253-3ovqhypt	55	36	infection	infection	NN
cord-262253-3ovqhypt	55	37	.	.	.
cord-262253-3ovqhypt	56	1	This	this	DT
cord-262253-3ovqhypt	56	2	led	lead	VBD
cord-262253-3ovqhypt	56	3	to	to	TO
cord-262253-3ovqhypt	56	4	lower	low	JJR
cord-262253-3ovqhypt	56	5	dosage	dosage	NN
cord-262253-3ovqhypt	56	6	recommendations	recommendation	NNS
cord-262253-3ovqhypt	56	7	for	for	IN
cord-262253-3ovqhypt	56	8	future	future	JJ
cord-262253-3ovqhypt	56	9	trials	trial	NNS
cord-262253-3ovqhypt	56	10	[	[	-LRB-
cord-262253-3ovqhypt	56	11	27	27	CD
cord-262253-3ovqhypt	56	12	,	,	,
cord-262253-3ovqhypt	56	13	28	28	CD
cord-262253-3ovqhypt	56	14	]	]	-RRB-
cord-262253-3ovqhypt	56	15	.	.	.
cord-262253-3ovqhypt	57	1	Lastly	lastly	RB
cord-262253-3ovqhypt	57	2	,	,	,
cord-262253-3ovqhypt	57	3	the	the	DT
cord-262253-3ovqhypt	57	4	B	b	NN
cord-262253-3ovqhypt	57	5	-	-	HYPH
cord-262253-3ovqhypt	57	6	site	site	NN
cord-262253-3ovqhypt	57	7	ABPP	ABPP	NNP
cord-262253-3ovqhypt	57	8	cleaving	cleave	VBG
cord-262253-3ovqhypt	57	9	enzyme	enzyme	NN
cord-262253-3ovqhypt	57	10	1	1	CD
cord-262253-3ovqhypt	57	11	(	(	-LRB-
cord-262253-3ovqhypt	57	12	BACE1)-inhibitor	BACE1)-inhibitor	NNP
cord-262253-3ovqhypt	57	13	E2609	E2609	NNP
cord-262253-3ovqhypt	57	14	has	have	VBZ
cord-262253-3ovqhypt	57	15	also	also	RB
cord-262253-3ovqhypt	57	16	been	be	VBN
cord-262253-3ovqhypt	57	17	associated	associate	VBN
cord-262253-3ovqhypt	57	18	with	with	IN
cord-262253-3ovqhypt	57	19	oralabial	oralabial	JJ
cord-262253-3ovqhypt	57	20	herpes	herpes	NN
cord-262253-3ovqhypt	57	21	relapse	relapse	NN
cord-262253-3ovqhypt	57	22	[	[	-LRB-
cord-262253-3ovqhypt	57	23	29	29	CD
cord-262253-3ovqhypt	57	24	,	,	,
cord-262253-3ovqhypt	57	25	30	30	CD
cord-262253-3ovqhypt	57	26	]	]	-RRB-
cord-262253-3ovqhypt	57	27	.	.	.
cord-262253-3ovqhypt	58	1	A	a	DT
cord-262253-3ovqhypt	58	2	rise	rise	NN
cord-262253-3ovqhypt	58	3	in	in	IN
cord-262253-3ovqhypt	58	4	infection	infection	NN
cord-262253-3ovqhypt	58	5	occurring	occur	VBG
cord-262253-3ovqhypt	58	6	in	in	IN
cord-262253-3ovqhypt	58	7	tandem	tandem	NN
cord-262253-3ovqhypt	58	8	with	with	IN
cord-262253-3ovqhypt	58	9	the	the	DT
cord-262253-3ovqhypt	58	10	reduction	reduction	NN
cord-262253-3ovqhypt	58	11	of	of	IN
cord-262253-3ovqhypt	58	12	Aβ	Aβ	NNP
cord-262253-3ovqhypt	58	13	peptide	peptide	JJ
cord-262253-3ovqhypt	58	14	production	production	NN
cord-262253-3ovqhypt	58	15	could	could	MD
cord-262253-3ovqhypt	58	16	indicate	indicate	VB
cord-262253-3ovqhypt	58	17	these	these	DT
cord-262253-3ovqhypt	58	18	peptides	peptide	NNS
cord-262253-3ovqhypt	58	19	'	'	POS
cord-262253-3ovqhypt	58	20	potential	potential	JJ
cord-262253-3ovqhypt	58	21	role	role	NN
cord-262253-3ovqhypt	58	22	in	in	IN
cord-262253-3ovqhypt	58	23	immune	immune	JJ
cord-262253-3ovqhypt	58	24	function	function	NN
cord-262253-3ovqhypt	58	25	.	.	.
cord-262253-3ovqhypt	59	1	Through	through	IN
cord-262253-3ovqhypt	59	2	these	these	DT
cord-262253-3ovqhypt	59	3	past	past	JJ
cord-262253-3ovqhypt	59	4	clinical	clinical	JJ
cord-262253-3ovqhypt	59	5	trials	trial	NNS
cord-262253-3ovqhypt	59	6	,	,	,
cord-262253-3ovqhypt	59	7	it	-PRON-	PRP
cord-262253-3ovqhypt	59	8	is	be	VBZ
cord-262253-3ovqhypt	59	9	evident	evident	JJ
cord-262253-3ovqhypt	59	10	that	that	IN
cord-262253-3ovqhypt	59	11	therapies	therapy	NNS
cord-262253-3ovqhypt	59	12	largely	largely	RB
cord-262253-3ovqhypt	59	13	based	base	VBN
cord-262253-3ovqhypt	59	14	on	on	IN
cord-262253-3ovqhypt	59	15	the	the	DT
cord-262253-3ovqhypt	59	16	amyloid	amyloid	NN
cord-262253-3ovqhypt	59	17	cascade	cascade	NN
cord-262253-3ovqhypt	59	18	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	59	19	,	,	,
cord-262253-3ovqhypt	59	20	which	which	WDT
cord-262253-3ovqhypt	59	21	in	in	IN
cord-262253-3ovqhypt	59	22	turn	turn	NN
cord-262253-3ovqhypt	59	23	aim	aim	VBP
cord-262253-3ovqhypt	59	24	to	to	TO
cord-262253-3ovqhypt	59	25	eradicate	eradicate	VB
cord-262253-3ovqhypt	59	26	Aβ	Aβ	NNP
cord-262253-3ovqhypt	59	27	peptides	peptide	NNS
cord-262253-3ovqhypt	59	28	in	in	IN
cord-262253-3ovqhypt	59	29	the	the	DT
cord-262253-3ovqhypt	59	30	brain	brain	NN
cord-262253-3ovqhypt	59	31	,	,	,
cord-262253-3ovqhypt	59	32	have	have	VBP
cord-262253-3ovqhypt	59	33	historically	historically	RB
cord-262253-3ovqhypt	59	34	been	be	VBN
cord-262253-3ovqhypt	59	35	ineffective	ineffective	JJ
cord-262253-3ovqhypt	59	36	.	.	.
cord-262253-3ovqhypt	60	1	These	these	DT
cord-262253-3ovqhypt	60	2	failures	failure	NNS
cord-262253-3ovqhypt	60	3	could	could	MD
cord-262253-3ovqhypt	60	4	imply	imply	VB
cord-262253-3ovqhypt	60	5	that	that	IN
cord-262253-3ovqhypt	60	6	current	current	JJ
cord-262253-3ovqhypt	60	7	approaches	approach	NNS
cord-262253-3ovqhypt	60	8	either	either	CC
cord-262253-3ovqhypt	60	9	intervene	intervene	VBP
cord-262253-3ovqhypt	60	10	at	at	IN
cord-262253-3ovqhypt	60	11	a	a	DT
cord-262253-3ovqhypt	60	12	stage	stage	NN
cord-262253-3ovqhypt	60	13	that	that	WDT
cord-262253-3ovqhypt	60	14	is	be	VBZ
cord-262253-3ovqhypt	60	15	too	too	RB
cord-262253-3ovqhypt	60	16	late	late	JJ
cord-262253-3ovqhypt	60	17	,	,	,
cord-262253-3ovqhypt	60	18	or	or	CC
cord-262253-3ovqhypt	60	19	possess	possess	VBP
cord-262253-3ovqhypt	60	20	a	a	DT
cord-262253-3ovqhypt	60	21	therapeutic	therapeutic	JJ
cord-262253-3ovqhypt	60	22	target	target	NN
cord-262253-3ovqhypt	60	23	that	that	WDT
cord-262253-3ovqhypt	60	24	is	be	VBZ
cord-262253-3ovqhypt	60	25	not	not	RB
cord-262253-3ovqhypt	60	26	as	as	RB
cord-262253-3ovqhypt	60	27	relevant	relevant	JJ
cord-262253-3ovqhypt	60	28	to	to	IN
cord-262253-3ovqhypt	60	29	disease	disease	NN
cord-262253-3ovqhypt	60	30	progression	progression	NN
cord-262253-3ovqhypt	60	31	[	[	-LRB-
cord-262253-3ovqhypt	60	32	31	31	CD
cord-262253-3ovqhypt	60	33	]	]	-RRB-
cord-262253-3ovqhypt	60	34	.	.	.
cord-262253-3ovqhypt	61	1	This	this	DT
cord-262253-3ovqhypt	61	2	would	would	MD
cord-262253-3ovqhypt	61	3	make	make	VB
cord-262253-3ovqhypt	61	4	sense	sense	NN
cord-262253-3ovqhypt	61	5	in	in	IN
cord-262253-3ovqhypt	61	6	the	the	DT
cord-262253-3ovqhypt	61	7	context	context	NN
cord-262253-3ovqhypt	61	8	of	of	IN
cord-262253-3ovqhypt	61	9	AD	ad	NN
cord-262253-3ovqhypt	61	10	especially	especially	RB
cord-262253-3ovqhypt	61	11	,	,	,
cord-262253-3ovqhypt	61	12	as	as	IN
cord-262253-3ovqhypt	61	13	Aβ	Aβ	NNP
cord-262253-3ovqhypt	61	14	deposition	deposition	NN
cord-262253-3ovqhypt	61	15	occurs	occur	VBZ
cord-262253-3ovqhypt	61	16	10	10	CD
cord-262253-3ovqhypt	61	17	-	-	SYM
cord-262253-3ovqhypt	61	18	20	20	CD
cord-262253-3ovqhypt	61	19	years	year	NNS
cord-262253-3ovqhypt	61	20	before	before	IN
cord-262253-3ovqhypt	61	21	the	the	DT
cord-262253-3ovqhypt	61	22	occurrence	occurrence	NN
cord-262253-3ovqhypt	61	23	of	of	IN
cord-262253-3ovqhypt	61	24	clinical	clinical	JJ
cord-262253-3ovqhypt	61	25	symptoms	symptom	NNS
cord-262253-3ovqhypt	61	26	[	[	-LRB-
cord-262253-3ovqhypt	61	27	32	32	CD
cord-262253-3ovqhypt	61	28	]	]	-RRB-
cord-262253-3ovqhypt	61	29	.	.	.
cord-262253-3ovqhypt	62	1	Therefore	therefore	RB
cord-262253-3ovqhypt	62	2	,	,	,
cord-262253-3ovqhypt	62	3	these	these	DT
cord-262253-3ovqhypt	62	4	treatments	treatment	NNS
cord-262253-3ovqhypt	62	5	that	that	WDT
cord-262253-3ovqhypt	62	6	target	target	VBP
cord-262253-3ovqhypt	62	7	Aβ	Aβ	NNP
cord-262253-3ovqhypt	62	8	peptides	peptide	NNS
cord-262253-3ovqhypt	62	9	specifically	specifically	RB
cord-262253-3ovqhypt	62	10	may	may	MD
cord-262253-3ovqhypt	62	11	already	already	RB
cord-262253-3ovqhypt	62	12	be	be	VB
cord-262253-3ovqhypt	62	13	too	too	RB
cord-262253-3ovqhypt	62	14	late	late	JJ
cord-262253-3ovqhypt	62	15	.	.	.
cord-262253-3ovqhypt	63	1	To	to	TO
cord-262253-3ovqhypt	63	2	create	create	VB
cord-262253-3ovqhypt	63	3	a	a	DT
cord-262253-3ovqhypt	63	4	successful	successful	JJ
cord-262253-3ovqhypt	63	5	therapy	therapy	NN
cord-262253-3ovqhypt	63	6	,	,	,
cord-262253-3ovqhypt	63	7	it	-PRON-	PRP
cord-262253-3ovqhypt	63	8	may	may	MD
cord-262253-3ovqhypt	63	9	be	be	VB
cord-262253-3ovqhypt	63	10	necessary	necessary	JJ
cord-262253-3ovqhypt	63	11	to	to	TO
cord-262253-3ovqhypt	63	12	consider	consider	VB
cord-262253-3ovqhypt	63	13	intervention	intervention	NN
cord-262253-3ovqhypt	63	14	in	in	IN
cord-262253-3ovqhypt	63	15	the	the	DT
cord-262253-3ovqhypt	63	16	presymptomatic	presymptomatic	JJ
cord-262253-3ovqhypt	63	17	stage	stage	NN
cord-262253-3ovqhypt	63	18	of	of	IN
cord-262253-3ovqhypt	63	19	the	the	DT
cord-262253-3ovqhypt	63	20	AD	ad	NN
cord-262253-3ovqhypt	63	21	instead	instead	RB
cord-262253-3ovqhypt	63	22	.	.	.
cord-262253-3ovqhypt	64	1	To	to	TO
cord-262253-3ovqhypt	64	2	do	do	VB
cord-262253-3ovqhypt	64	3	so	so	RB
cord-262253-3ovqhypt	64	4	,	,	,
cord-262253-3ovqhypt	64	5	it	-PRON-	PRP
cord-262253-3ovqhypt	64	6	would	would	MD
cord-262253-3ovqhypt	64	7	be	be	VB
cord-262253-3ovqhypt	64	8	crucial	crucial	JJ
cord-262253-3ovqhypt	64	9	to	to	TO
cord-262253-3ovqhypt	64	10	identify	identify	VB
cord-262253-3ovqhypt	64	11	biomarkers	biomarker	NNS
cord-262253-3ovqhypt	64	12	for	for	IN
cord-262253-3ovqhypt	64	13	early	early	JJ
cord-262253-3ovqhypt	64	14	identification	identification	NN
cord-262253-3ovqhypt	64	15	of	of	IN
cord-262253-3ovqhypt	64	16	AD	ad	NN
cord-262253-3ovqhypt	64	17	.	.	.
cord-262253-3ovqhypt	65	1	In	in	IN
cord-262253-3ovqhypt	65	2	March	March	NNP
cord-262253-3ovqhypt	65	3	of	of	IN
cord-262253-3ovqhypt	65	4	2016	2016	CD
cord-262253-3ovqhypt	65	5	,	,	,
cord-262253-3ovqhypt	65	6	a	a	DT
cord-262253-3ovqhypt	65	7	meeting	meeting	NN
cord-262253-3ovqhypt	65	8	was	be	VBD
cord-262253-3ovqhypt	65	9	convened	convene	VBN
cord-262253-3ovqhypt	65	10	in	in	IN
cord-262253-3ovqhypt	65	11	which	which	WDT
cord-262253-3ovqhypt	65	12	international	international	JJ
cord-262253-3ovqhypt	65	13	,	,	,
cord-262253-3ovqhypt	65	14	interdisciplinary	interdisciplinary	JJ
cord-262253-3ovqhypt	65	15	experts	expert	NNS
cord-262253-3ovqhypt	65	16	identified	identify	VBD
cord-262253-3ovqhypt	65	17	a	a	DT
cord-262253-3ovqhypt	65	18	list	list	NN
cord-262253-3ovqhypt	65	19	of	of	IN
cord-262253-3ovqhypt	65	20	biomarkers	biomarker	NNS
cord-262253-3ovqhypt	65	21	that	that	WDT
cord-262253-3ovqhypt	65	22	could	could	MD
cord-262253-3ovqhypt	65	23	be	be	VB
cord-262253-3ovqhypt	65	24	used	use	VBN
cord-262253-3ovqhypt	65	25	for	for	IN
cord-262253-3ovqhypt	65	26	identifying	identify	VBG
cord-262253-3ovqhypt	65	27	AD	ad	NN
cord-262253-3ovqhypt	65	28	early	early	RB
cord-262253-3ovqhypt	65	29	on	on	IN
cord-262253-3ovqhypt	65	30	[	[	-LRB-
cord-262253-3ovqhypt	65	31	33	33	CD
cord-262253-3ovqhypt	65	32	]	]	-RRB-
cord-262253-3ovqhypt	65	33	.	.	.
cord-262253-3ovqhypt	66	1	CSF	csf	NN
cord-262253-3ovqhypt	66	2	levels	level	NNS
cord-262253-3ovqhypt	66	3	of	of	IN
cord-262253-3ovqhypt	66	4	Aβ	Aβ	NNP
cord-262253-3ovqhypt	66	5	1	1	CD
cord-262253-3ovqhypt	66	6	-	-	SYM
cord-262253-3ovqhypt	66	7	42	42	CD
cord-262253-3ovqhypt	66	8	and	and	CC
cord-262253-3ovqhypt	66	9	Aβ	Aβ	NNP
cord-262253-3ovqhypt	66	10	,	,	,
cord-262253-3ovqhypt	66	11	and	and	CC
cord-262253-3ovqhypt	66	12	the	the	DT
cord-262253-3ovqhypt	66	13	ratio	ratio	NN
cord-262253-3ovqhypt	66	14	of	of	IN
cord-262253-3ovqhypt	66	15	Aβ	Aβ	NNP
cord-262253-3ovqhypt	66	16	1	1	CD
cord-262253-3ovqhypt	66	17	-	-	SYM
cord-262253-3ovqhypt	66	18	42	42	CD
cord-262253-3ovqhypt	66	19	/Aβ	/aβ	NN
cord-262253-3ovqhypt	67	1	1	1	LS
cord-262253-3ovqhypt	67	2	-	-	SYM
cord-262253-3ovqhypt	67	3	40	40	CD
cord-262253-3ovqhypt	67	4	,	,	,
cord-262253-3ovqhypt	67	5	were	be	VBD
cord-262253-3ovqhypt	67	6	determined	determine	VBN
cord-262253-3ovqhypt	67	7	to	to	TO
cord-262253-3ovqhypt	67	8	be	be	VB
cord-262253-3ovqhypt	67	9	among	among	IN
cord-262253-3ovqhypt	67	10	the	the	DT
cord-262253-3ovqhypt	67	11	candidates	candidate	NNS
cord-262253-3ovqhypt	67	12	[	[	-LRB-
cord-262253-3ovqhypt	67	13	33	33	CD
cord-262253-3ovqhypt	67	14	,	,	,
cord-262253-3ovqhypt	67	15	34	34	CD
cord-262253-3ovqhypt	67	16	]	]	-RRB-
cord-262253-3ovqhypt	67	17	.	.	.
cord-262253-3ovqhypt	68	1	In	in	IN
cord-262253-3ovqhypt	68	2	addition	addition	NN
cord-262253-3ovqhypt	68	3	,	,	,
cord-262253-3ovqhypt	68	4	plasma	plasma	NN
cord-262253-3ovqhypt	68	5	levels	level	NNS
cord-262253-3ovqhypt	68	6	of	of	IN
cord-262253-3ovqhypt	68	7	the	the	DT
cord-262253-3ovqhypt	68	8	same	same	JJ
cord-262253-3ovqhypt	68	9	biomarkers	biomarker	NNS
cord-262253-3ovqhypt	68	10	were	be	VBD
cord-262253-3ovqhypt	68	11	determined	determine	VBN
cord-262253-3ovqhypt	68	12	to	to	TO
cord-262253-3ovqhypt	68	13	decrease	decrease	VB
cord-262253-3ovqhypt	68	14	in	in	IN
cord-262253-3ovqhypt	68	15	AD	ad	NN
cord-262253-3ovqhypt	68	16	patients	patient	NNS
cord-262253-3ovqhypt	68	17	when	when	WRB
cord-262253-3ovqhypt	68	18	compared	compare	VBN
cord-262253-3ovqhypt	68	19	to	to	IN
cord-262253-3ovqhypt	68	20	healthy	healthy	JJ
cord-262253-3ovqhypt	68	21	subjects	subject	NNS
cord-262253-3ovqhypt	68	22	[	[	-LRB-
cord-262253-3ovqhypt	68	23	35	35	CD
cord-262253-3ovqhypt	68	24	]	]	-RRB-
cord-262253-3ovqhypt	68	25	.	.	.
cord-262253-3ovqhypt	69	1	Other	other	JJ
cord-262253-3ovqhypt	69	2	biomarkers	biomarker	NNS
cord-262253-3ovqhypt	69	3	to	to	TO
cord-262253-3ovqhypt	69	4	consider	consider	VB
cord-262253-3ovqhypt	69	5	would	would	MD
cord-262253-3ovqhypt	69	6	include	include	VB
cord-262253-3ovqhypt	69	7	plasma	plasma	NN
cord-262253-3ovqhypt	69	8	levels	level	NNS
cord-262253-3ovqhypt	69	9	of	of	IN
cord-262253-3ovqhypt	69	10	tau	tau	NNP
cord-262253-3ovqhypt	69	11	protein	protein	NNP
cord-262253-3ovqhypt	69	12	and	and	CC
cord-262253-3ovqhypt	69	13	neurofilament	neurofilament	NNP
cord-262253-3ovqhypt	69	14	light	light	NN
cord-262253-3ovqhypt	69	15	[	[	-LRB-
cord-262253-3ovqhypt	69	16	33	33	CD
cord-262253-3ovqhypt	69	17	]	]	-RRB-
cord-262253-3ovqhypt	69	18	.	.	.
cord-262253-3ovqhypt	70	1	Plasma	plasma	NN
cord-262253-3ovqhypt	70	2	levels	level	NNS
cord-262253-3ovqhypt	70	3	of	of	IN
cord-262253-3ovqhypt	70	4	the	the	DT
cord-262253-3ovqhypt	70	5	latter	latter	JJ
cord-262253-3ovqhypt	70	6	have	have	VBP
cord-262253-3ovqhypt	70	7	been	be	VBN
cord-262253-3ovqhypt	70	8	shown	show	VBN
cord-262253-3ovqhypt	70	9	to	to	TO
cord-262253-3ovqhypt	70	10	be	be	VB
cord-262253-3ovqhypt	70	11	able	able	JJ
cord-262253-3ovqhypt	70	12	to	to	TO
cord-262253-3ovqhypt	70	13	detect	detect	VB
cord-262253-3ovqhypt	70	14	neurodegeneration	neurodegeneration	NN
cord-262253-3ovqhypt	70	15	in	in	IN
cord-262253-3ovqhypt	70	16	presymptomatic	presymptomatic	JJ
cord-262253-3ovqhypt	70	17	AD	ad	NN
cord-262253-3ovqhypt	70	18	[	[	-LRB-
cord-262253-3ovqhypt	70	19	36	36	CD
cord-262253-3ovqhypt	70	20	]	]	-RRB-
cord-262253-3ovqhypt	70	21	.	.	.
cord-262253-3ovqhypt	71	1	Other	other	JJ
cord-262253-3ovqhypt	71	2	highly	highly	RB
cord-262253-3ovqhypt	71	3	sensitive	sensitive	JJ
cord-262253-3ovqhypt	71	4	methods	method	NNS
cord-262253-3ovqhypt	71	5	that	that	WDT
cord-262253-3ovqhypt	71	6	have	have	VBP
cord-262253-3ovqhypt	71	7	shown	show	VBN
cord-262253-3ovqhypt	71	8	promise	promise	NN
cord-262253-3ovqhypt	71	9	in	in	IN
cord-262253-3ovqhypt	71	10	the	the	DT
cord-262253-3ovqhypt	71	11	early	early	JJ
cord-262253-3ovqhypt	71	12	identification	identification	NN
cord-262253-3ovqhypt	71	13	of	of	IN
cord-262253-3ovqhypt	71	14	AD	ad	NN
cord-262253-3ovqhypt	71	15	include	include	VBP
cord-262253-3ovqhypt	71	16	protein	protein	NN
cord-262253-3ovqhypt	71	17	misfolding	misfolde	VBG
cord-262253-3ovqhypt	71	18	cyclic	cyclic	JJ
cord-262253-3ovqhypt	71	19	amplification	amplification	NN
cord-262253-3ovqhypt	71	20	(	(	-LRB-
cord-262253-3ovqhypt	71	21	PMCA	PMCA	NNP
cord-262253-3ovqhypt	71	22	)	)	-RRB-
cord-262253-3ovqhypt	71	23	and	and	CC
cord-262253-3ovqhypt	71	24	real	real	JJ
cord-262253-3ovqhypt	71	25	-	-	HYPH
cord-262253-3ovqhypt	71	26	time	time	NN
cord-262253-3ovqhypt	71	27	quaking	quaking	NN
cord-262253-3ovqhypt	71	28	-	-	HYPH
cord-262253-3ovqhypt	71	29	induced	induce	VBN
cord-262253-3ovqhypt	71	30	conversion	conversion	NN
cord-262253-3ovqhypt	71	31	(	(	-LRB-
cord-262253-3ovqhypt	71	32	RT	RT	NNP
cord-262253-3ovqhypt	71	33	-	-	HYPH
cord-262253-3ovqhypt	71	34	QuIC	QuIC	NNP
cord-262253-3ovqhypt	71	35	)	)	-RRB-
cord-262253-3ovqhypt	71	36	,	,	,
cord-262253-3ovqhypt	71	37	to	to	TO
cord-262253-3ovqhypt	71	38	determine	determine	VB
cord-262253-3ovqhypt	71	39	Aβ	Aβ	NNP
cord-262253-3ovqhypt	71	40	oligomers	oligomer	NNS
cord-262253-3ovqhypt	71	41	and	and	CC
cord-262253-3ovqhypt	71	42	tau	tau	NN
cord-262253-3ovqhypt	71	43	protein	protein	NN
cord-262253-3ovqhypt	71	44	levels	level	NNS
cord-262253-3ovqhypt	71	45	in	in	IN
cord-262253-3ovqhypt	71	46	CSF	CSF	NNP
cord-262253-3ovqhypt	71	47	[	[	-LRB-
cord-262253-3ovqhypt	71	48	37	37	CD
cord-262253-3ovqhypt	71	49	,	,	,
cord-262253-3ovqhypt	71	50	38	38	CD
cord-262253-3ovqhypt	71	51	]	]	-RRB-
cord-262253-3ovqhypt	71	52	.	.	.
cord-262253-3ovqhypt	72	1	Taking	take	VBG
cord-262253-3ovqhypt	72	2	a	a	DT
cord-262253-3ovqhypt	72	3	more	more	RBR
cord-262253-3ovqhypt	72	4	preventative	preventative	JJ
cord-262253-3ovqhypt	72	5	approach	approach	NN
cord-262253-3ovqhypt	72	6	to	to	IN
cord-262253-3ovqhypt	72	7	AD	ad	NN
cord-262253-3ovqhypt	72	8	treatment	treatment	NN
cord-262253-3ovqhypt	72	9	,	,	,
cord-262253-3ovqhypt	72	10	and	and	CC
cord-262253-3ovqhypt	72	11	understanding	understanding	NN
cord-262253-3ovqhypt	72	12	and	and	CC
cord-262253-3ovqhypt	72	13	addressing	address	VBG
cord-262253-3ovqhypt	72	14	factors	factor	NNS
cord-262253-3ovqhypt	72	15	that	that	WDT
cord-262253-3ovqhypt	72	16	contribute	contribute	VBP
cord-262253-3ovqhypt	72	17	to	to	IN
cord-262253-3ovqhypt	72	18	the	the	DT
cord-262253-3ovqhypt	72	19	progression	progression	NN
cord-262253-3ovqhypt	72	20	of	of	IN
cord-262253-3ovqhypt	72	21	AD	ad	NN
cord-262253-3ovqhypt	72	22	,	,	,
cord-262253-3ovqhypt	72	23	may	may	MD
cord-262253-3ovqhypt	72	24	be	be	VB
cord-262253-3ovqhypt	72	25	favorable	favorable	JJ
cord-262253-3ovqhypt	72	26	for	for	IN
cord-262253-3ovqhypt	72	27	identifying	identify	VBG
cord-262253-3ovqhypt	72	28	therapeutic	therapeutic	JJ
cord-262253-3ovqhypt	72	29	targets	target	NNS
cord-262253-3ovqhypt	72	30	earlier	early	RBR
cord-262253-3ovqhypt	72	31	in	in	IN
cord-262253-3ovqhypt	72	32	the	the	DT
cord-262253-3ovqhypt	72	33	disease	disease	NN
cord-262253-3ovqhypt	72	34	.	.	.
cord-262253-3ovqhypt	73	1	Based	base	VBN
cord-262253-3ovqhypt	73	2	on	on	IN
cord-262253-3ovqhypt	73	3	evidence	evidence	NN
cord-262253-3ovqhypt	73	4	of	of	IN
cord-262253-3ovqhypt	73	5	the	the	DT
cord-262253-3ovqhypt	73	6	association	association	NN
cord-262253-3ovqhypt	73	7	between	between	IN
cord-262253-3ovqhypt	73	8	bacterial	bacterial	JJ
cord-262253-3ovqhypt	73	9	/	/	SYM
cord-262253-3ovqhypt	73	10	viral	viral	JJ
cord-262253-3ovqhypt	73	11	infection	infection	NN
cord-262253-3ovqhypt	73	12	and	and	CC
cord-262253-3ovqhypt	73	13	AD	ad	NN
cord-262253-3ovqhypt	73	14	progression	progression	NN
cord-262253-3ovqhypt	73	15	,	,	,
cord-262253-3ovqhypt	73	16	the	the	DT
cord-262253-3ovqhypt	73	17	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	73	18	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	73	19	suggests	suggest	VBZ
cord-262253-3ovqhypt	73	20	that	that	IN
cord-262253-3ovqhypt	73	21	Aβ	Aβ	NNP
cord-262253-3ovqhypt	73	22	peptides	peptide	NNS
cord-262253-3ovqhypt	73	23	may	may	MD
cord-262253-3ovqhypt	73	24	be	be	VB
cord-262253-3ovqhypt	73	25	produced	produce	VBN
cord-262253-3ovqhypt	73	26	as	as	IN
cord-262253-3ovqhypt	73	27	a	a	DT
cord-262253-3ovqhypt	73	28	protective	protective	JJ
cord-262253-3ovqhypt	73	29	mechanism	mechanism	NN
cord-262253-3ovqhypt	73	30	by	by	IN
cord-262253-3ovqhypt	73	31	the	the	DT
cord-262253-3ovqhypt	73	32	innate	innate	JJ
cord-262253-3ovqhypt	73	33	immune	immune	JJ
cord-262253-3ovqhypt	73	34	system	system	NN
cord-262253-3ovqhypt	73	35	,	,	,
cord-262253-3ovqhypt	73	36	and	and	CC
cord-262253-3ovqhypt	73	37	act	act	VB
cord-262253-3ovqhypt	73	38	as	as	IN
cord-262253-3ovqhypt	73	39	an	an	DT
cord-262253-3ovqhypt	73	40	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	73	41	peptide	peptide	NN
cord-262253-3ovqhypt	73	42	(	(	-LRB-
cord-262253-3ovqhypt	73	43	AMP	AMP	NNP
cord-262253-3ovqhypt	73	44	)	)	-RRB-
cord-262253-3ovqhypt	73	45	against	against	IN
cord-262253-3ovqhypt	73	46	foreign	foreign	JJ
cord-262253-3ovqhypt	73	47	agents	agent	NNS
cord-262253-3ovqhypt	73	48	.	.	.
cord-262253-3ovqhypt	74	1	If	if	IN
cord-262253-3ovqhypt	74	2	Aβ	Aβ	NNP
cord-262253-3ovqhypt	74	3	peptides	peptide	NNS
cord-262253-3ovqhypt	74	4	do	do	VBP
cord-262253-3ovqhypt	74	5	in	in	IN
cord-262253-3ovqhypt	74	6	fact	fact	NN
cord-262253-3ovqhypt	74	7	play	play	VB
cord-262253-3ovqhypt	74	8	a	a	DT
cord-262253-3ovqhypt	74	9	beneficial	beneficial	JJ
cord-262253-3ovqhypt	74	10	role	role	NN
cord-262253-3ovqhypt	74	11	in	in	IN
cord-262253-3ovqhypt	74	12	immunity	immunity	NN
cord-262253-3ovqhypt	74	13	,	,	,
cord-262253-3ovqhypt	74	14	then	then	RB
cord-262253-3ovqhypt	74	15	the	the	DT
cord-262253-3ovqhypt	74	16	aim	aim	NN
cord-262253-3ovqhypt	74	17	of	of	IN
cord-262253-3ovqhypt	74	18	treatment	treatment	NN
cord-262253-3ovqhypt	74	19	should	should	MD
cord-262253-3ovqhypt	74	20	not	not	RB
cord-262253-3ovqhypt	74	21	be	be	VB
cord-262253-3ovqhypt	74	22	to	to	TO
cord-262253-3ovqhypt	74	23	eradicate	eradicate	VB
cord-262253-3ovqhypt	74	24	the	the	DT
cord-262253-3ovqhypt	74	25	compound	compound	NN
cord-262253-3ovqhypt	74	26	entirely	entirely	RB
cord-262253-3ovqhypt	74	27	.	.	.
cord-262253-3ovqhypt	75	1	Rather	rather	RB
cord-262253-3ovqhypt	75	2	,	,	,
cord-262253-3ovqhypt	75	3	it	-PRON-	PRP
cord-262253-3ovqhypt	75	4	should	should	MD
cord-262253-3ovqhypt	75	5	be	be	VB
cord-262253-3ovqhypt	75	6	to	to	TO
cord-262253-3ovqhypt	75	7	target	target	VB
cord-262253-3ovqhypt	75	8	the	the	DT
cord-262253-3ovqhypt	75	9	root	root	NN
cord-262253-3ovqhypt	75	10	cause	cause	NN
cord-262253-3ovqhypt	75	11	of	of	IN
cord-262253-3ovqhypt	75	12	its	-PRON-	PRP$
cord-262253-3ovqhypt	75	13	over	over	IN
cord-262253-3ovqhypt	75	14	production	production	NN
cord-262253-3ovqhypt	75	15	,	,	,
cord-262253-3ovqhypt	75	16	and	and	CC
cord-262253-3ovqhypt	75	17	reduce	reduce	VB
cord-262253-3ovqhypt	75	18	its	-PRON-	PRP$
cord-262253-3ovqhypt	75	19	deleterious	deleterious	JJ
cord-262253-3ovqhypt	75	20	effects	effect	NNS
cord-262253-3ovqhypt	75	21	and	and	CC
cord-262253-3ovqhypt	75	22	general	general	JJ
cord-262253-3ovqhypt	75	23	neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	75	24	in	in	IN
cord-262253-3ovqhypt	75	25	AD	ad	NN
cord-262253-3ovqhypt	75	26	.	.	.
cord-262253-3ovqhypt	76	1	Neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	76	2	is	be	VBZ
cord-262253-3ovqhypt	76	3	inflammation	inflammation	NN
cord-262253-3ovqhypt	76	4	within	within	IN
cord-262253-3ovqhypt	76	5	the	the	DT
cord-262253-3ovqhypt	76	6	brain	brain	NN
cord-262253-3ovqhypt	76	7	or	or	CC
cord-262253-3ovqhypt	76	8	spinal	spinal	JJ
cord-262253-3ovqhypt	76	9	cord	cord	NN
cord-262253-3ovqhypt	76	10	due	due	IN
cord-262253-3ovqhypt	76	11	to	to	IN
cord-262253-3ovqhypt	76	12	infection	infection	NN
cord-262253-3ovqhypt	76	13	,	,	,
cord-262253-3ovqhypt	76	14	toxins	toxin	NNS
cord-262253-3ovqhypt	76	15	or	or	CC
cord-262253-3ovqhypt	76	16	injury	injury	NN
cord-262253-3ovqhypt	76	17	[	[	-LRB-
cord-262253-3ovqhypt	76	18	39	39	CD
cord-262253-3ovqhypt	76	19	]	]	-RRB-
cord-262253-3ovqhypt	76	20	.	.	.
cord-262253-3ovqhypt	77	1	In	in	IN
cord-262253-3ovqhypt	77	2	the	the	DT
cord-262253-3ovqhypt	77	3	brain	brain	NN
cord-262253-3ovqhypt	77	4	specifically	specifically	RB
cord-262253-3ovqhypt	77	5	,	,	,
cord-262253-3ovqhypt	77	6	resident	resident	JJ
cord-262253-3ovqhypt	77	7	glial	glial	JJ
cord-262253-3ovqhypt	77	8	cells	cell	NNS
cord-262253-3ovqhypt	77	9	,	,	,
cord-262253-3ovqhypt	77	10	such	such	JJ
cord-262253-3ovqhypt	77	11	as	as	IN
cord-262253-3ovqhypt	77	12	microglia	microglia	NN
cord-262253-3ovqhypt	77	13	and	and	CC
cord-262253-3ovqhypt	77	14	astrocytes	astrocyte	NNS
cord-262253-3ovqhypt	77	15	,	,	,
cord-262253-3ovqhypt	77	16	along	along	IN
cord-262253-3ovqhypt	77	17	with	with	IN
cord-262253-3ovqhypt	77	18	endothelial	endothelial	JJ
cord-262253-3ovqhypt	77	19	cells	cell	NNS
cord-262253-3ovqhypt	77	20	and	and	CC
cord-262253-3ovqhypt	77	21	mast	mast	NN
cord-262253-3ovqhypt	77	22	cells	cell	NNS
cord-262253-3ovqhypt	77	23	,	,	,
cord-262253-3ovqhypt	77	24	all	all	DT
cord-262253-3ovqhypt	77	25	aid	aid	NN
cord-262253-3ovqhypt	77	26	in	in	IN
cord-262253-3ovqhypt	77	27	defending	defend	VBG
cord-262253-3ovqhypt	77	28	the	the	DT
cord-262253-3ovqhypt	77	29	brain	brain	NN
cord-262253-3ovqhypt	77	30	against	against	IN
cord-262253-3ovqhypt	77	31	foreign	foreign	JJ
cord-262253-3ovqhypt	77	32	pathogens	pathogen	NNS
cord-262253-3ovqhypt	77	33	[	[	-LRB-
cord-262253-3ovqhypt	77	34	40	40	CD
cord-262253-3ovqhypt	77	35	]	]	-RRB-
cord-262253-3ovqhypt	77	36	.	.	.
cord-262253-3ovqhypt	78	1	Microglia	Microglia	NNP
cord-262253-3ovqhypt	78	2	,	,	,
cord-262253-3ovqhypt	78	3	the	the	DT
cord-262253-3ovqhypt	78	4	main	main	JJ
cord-262253-3ovqhypt	78	5	immune	immune	JJ
cord-262253-3ovqhypt	78	6	effector	effector	NN
cord-262253-3ovqhypt	78	7	cells	cell	NNS
cord-262253-3ovqhypt	78	8	of	of	IN
cord-262253-3ovqhypt	78	9	the	the	DT
cord-262253-3ovqhypt	78	10	central	central	JJ
cord-262253-3ovqhypt	78	11	nervous	nervous	JJ
cord-262253-3ovqhypt	78	12	system	system	NN
cord-262253-3ovqhypt	78	13	(	(	-LRB-
cord-262253-3ovqhypt	78	14	CNS	CNS	NNP
cord-262253-3ovqhypt	78	15	)	)	-RRB-
cord-262253-3ovqhypt	78	16	,	,	,
cord-262253-3ovqhypt	78	17	are	be	VBP
cord-262253-3ovqhypt	78	18	constantly	constantly	RB
cord-262253-3ovqhypt	78	19	surveying	survey	VBG
cord-262253-3ovqhypt	78	20	their	-PRON-	PRP$
cord-262253-3ovqhypt	78	21	environment	environment	NN
cord-262253-3ovqhypt	78	22	for	for	IN
cord-262253-3ovqhypt	78	23	potential	potential	JJ
cord-262253-3ovqhypt	78	24	threats	threat	NNS
cord-262253-3ovqhypt	78	25	to	to	IN
cord-262253-3ovqhypt	78	26	the	the	DT
cord-262253-3ovqhypt	78	27	brain	brain	NN
cord-262253-3ovqhypt	78	28	[	[	-LRB-
cord-262253-3ovqhypt	78	29	41	41	CD
cord-262253-3ovqhypt	78	30	,	,	,
cord-262253-3ovqhypt	78	31	42	42	CD
cord-262253-3ovqhypt	78	32	]	]	-RRB-
cord-262253-3ovqhypt	78	33	.	.	.
cord-262253-3ovqhypt	79	1	When	when	WRB
cord-262253-3ovqhypt	79	2	an	an	DT
cord-262253-3ovqhypt	79	3	invading	invade	VBG
cord-262253-3ovqhypt	79	4	agent	agent	NN
cord-262253-3ovqhypt	79	5	is	be	VBZ
cord-262253-3ovqhypt	79	6	detected	detect	VBN
cord-262253-3ovqhypt	79	7	,	,	,
cord-262253-3ovqhypt	79	8	microglia	microglia	JJ
cord-262253-3ovqhypt	79	9	change	change	NN
cord-262253-3ovqhypt	79	10	into	into	IN
cord-262253-3ovqhypt	79	11	an	an	DT
cord-262253-3ovqhypt	79	12	activated	activate	VBN
cord-262253-3ovqhypt	79	13	state	state	NN
cord-262253-3ovqhypt	79	14	,	,	,
cord-262253-3ovqhypt	79	15	characterized	characterize	VBN
cord-262253-3ovqhypt	79	16	by	by	IN
cord-262253-3ovqhypt	79	17	an	an	DT
cord-262253-3ovqhypt	79	18	enlarged	enlarged	JJ
cord-262253-3ovqhypt	79	19	soma	soma	NN
cord-262253-3ovqhypt	79	20	and	and	CC
cord-262253-3ovqhypt	79	21	the	the	DT
cord-262253-3ovqhypt	79	22	production	production	NN
cord-262253-3ovqhypt	79	23	of	of	IN
cord-262253-3ovqhypt	79	24	inflammatory	inflammatory	JJ
cord-262253-3ovqhypt	79	25	cytokines	cytokine	NNS
cord-262253-3ovqhypt	79	26	and	and	CC
cord-262253-3ovqhypt	79	27	chemokines	chemokine	NNS
cord-262253-3ovqhypt	79	28	[	[	-LRB-
cord-262253-3ovqhypt	79	29	39	39	CD
cord-262253-3ovqhypt	79	30	]	]	-RRB-
cord-262253-3ovqhypt	79	31	.	.	.
cord-262253-3ovqhypt	80	1	Astrocytes	Astrocytes	NNP
cord-262253-3ovqhypt	80	2	also	also	RB
cord-262253-3ovqhypt	80	3	play	play	VBP
cord-262253-3ovqhypt	80	4	a	a	DT
cord-262253-3ovqhypt	80	5	critical	critical	JJ
cord-262253-3ovqhypt	80	6	role	role	NN
cord-262253-3ovqhypt	80	7	in	in	IN
cord-262253-3ovqhypt	80	8	mediating	mediate	VBG
cord-262253-3ovqhypt	80	9	neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	80	10	as	as	IN
cord-262253-3ovqhypt	80	11	they	-PRON-	PRP
cord-262253-3ovqhypt	80	12	are	be	VBP
cord-262253-3ovqhypt	80	13	responsible	responsible	JJ
cord-262253-3ovqhypt	80	14	for	for	IN
cord-262253-3ovqhypt	80	15	many	many	JJ
cord-262253-3ovqhypt	80	16	neuroprotective	neuroprotective	JJ
cord-262253-3ovqhypt	80	17	functions	function	NNS
cord-262253-3ovqhypt	80	18	,	,	,
cord-262253-3ovqhypt	80	19	such	such	JJ
cord-262253-3ovqhypt	80	20	as	as	IN
cord-262253-3ovqhypt	80	21	maintaining	maintain	VBG
cord-262253-3ovqhypt	80	22	blood	blood	NN
cord-262253-3ovqhypt	80	23	brain	brain	NN
cord-262253-3ovqhypt	80	24	barrier	barrier	NN
cord-262253-3ovqhypt	80	25	(	(	-LRB-
cord-262253-3ovqhypt	80	26	BBB	BBB	NNP
cord-262253-3ovqhypt	80	27	)	)	-RRB-
cord-262253-3ovqhypt	80	28	integrity	integrity	NN
cord-262253-3ovqhypt	80	29	and	and	CC
cord-262253-3ovqhypt	80	30	buffering	buffer	VBG
cord-262253-3ovqhypt	80	31	neurotransmitters	neurotransmitter	NNS
cord-262253-3ovqhypt	80	32	[	[	-LRB-
cord-262253-3ovqhypt	80	33	43	43	CD
cord-262253-3ovqhypt	80	34	]	]	-RRB-
cord-262253-3ovqhypt	80	35	.	.	.
cord-262253-3ovqhypt	81	1	Upon	upon	IN
cord-262253-3ovqhypt	81	2	injury	injury	NN
cord-262253-3ovqhypt	81	3	,	,	,
cord-262253-3ovqhypt	81	4	astrocytes	astrocyte	NNS
cord-262253-3ovqhypt	81	5	likewise	likewise	RB
cord-262253-3ovqhypt	81	6	undergo	undergo	VBP
cord-262253-3ovqhypt	81	7	morphological	morphological	JJ
cord-262253-3ovqhypt	81	8	changes	change	NNS
cord-262253-3ovqhypt	81	9	,	,	,
cord-262253-3ovqhypt	81	10	and	and	CC
cord-262253-3ovqhypt	81	11	exhibit	exhibit	VB
cord-262253-3ovqhypt	81	12	increased	increase	VBN
cord-262253-3ovqhypt	81	13	reactivity	reactivity	NN
cord-262253-3ovqhypt	81	14	and	and	CC
cord-262253-3ovqhypt	81	15	secretion	secretion	NN
cord-262253-3ovqhypt	81	16	of	of	IN
cord-262253-3ovqhypt	81	17	cytokines	cytokine	NNS
cord-262253-3ovqhypt	81	18	and	and	CC
cord-262253-3ovqhypt	81	19	chemokines	chemokine	NNS
cord-262253-3ovqhypt	81	20	[	[	-LRB-
cord-262253-3ovqhypt	81	21	41	41	CD
cord-262253-3ovqhypt	81	22	]	]	-RRB-
cord-262253-3ovqhypt	81	23	.	.	.
cord-262253-3ovqhypt	82	1	While	while	IN
cord-262253-3ovqhypt	82	2	acute	acute	JJ
cord-262253-3ovqhypt	82	3	inflammatory	inflammatory	JJ
cord-262253-3ovqhypt	82	4	responses	response	NNS
cord-262253-3ovqhypt	82	5	are	be	VBP
cord-262253-3ovqhypt	82	6	common	common	JJ
cord-262253-3ovqhypt	82	7	to	to	IN
cord-262253-3ovqhypt	82	8	healthy	healthy	JJ
cord-262253-3ovqhypt	82	9	individuals	individual	NNS
cord-262253-3ovqhypt	82	10	,	,	,
cord-262253-3ovqhypt	82	11	chronic	chronic	JJ
cord-262253-3ovqhypt	82	12	inflammation	inflammation	NN
cord-262253-3ovqhypt	82	13	is	be	VBZ
cord-262253-3ovqhypt	82	14	damaging	damaging	JJ
cord-262253-3ovqhypt	82	15	to	to	IN
cord-262253-3ovqhypt	82	16	the	the	DT
cord-262253-3ovqhypt	82	17	natural	natural	JJ
cord-262253-3ovqhypt	82	18	balance	balance	NN
cord-262253-3ovqhypt	82	19	of	of	IN
cord-262253-3ovqhypt	82	20	pro	pro	JJ
cord-262253-3ovqhypt	82	21	-	-	JJ
cord-262253-3ovqhypt	82	22	and	and	CC
cord-262253-3ovqhypt	82	23	anti	anti	JJ
cord-262253-3ovqhypt	82	24	-	-	JJ
cord-262253-3ovqhypt	82	25	inflammatory	inflammatory	JJ
cord-262253-3ovqhypt	82	26	signaling	signaling	NN
cord-262253-3ovqhypt	82	27	in	in	IN
cord-262253-3ovqhypt	82	28	the	the	DT
cord-262253-3ovqhypt	82	29	brain	brain	NN
cord-262253-3ovqhypt	82	30	,	,	,
cord-262253-3ovqhypt	82	31	and	and	CC
cord-262253-3ovqhypt	82	32	can	can	MD
cord-262253-3ovqhypt	82	33	lead	lead	VB
cord-262253-3ovqhypt	82	34	to	to	IN
cord-262253-3ovqhypt	82	35	the	the	DT
cord-262253-3ovqhypt	82	36	development	development	NN
cord-262253-3ovqhypt	82	37	and	and	CC
cord-262253-3ovqhypt	82	38	progression	progression	NN
cord-262253-3ovqhypt	82	39	of	of	IN
cord-262253-3ovqhypt	82	40	neurodegenerative	neurodegenerative	JJ
cord-262253-3ovqhypt	82	41	diseases	disease	NNS
cord-262253-3ovqhypt	82	42	like	like	IN
cord-262253-3ovqhypt	82	43	AD	ad	NN
cord-262253-3ovqhypt	82	44	[	[	-LRB-
cord-262253-3ovqhypt	82	45	39	39	CD
cord-262253-3ovqhypt	82	46	]	]	-RRB-
cord-262253-3ovqhypt	82	47	.	.	.
cord-262253-3ovqhypt	83	1	Over	over	IN
cord-262253-3ovqhypt	83	2	the	the	DT
cord-262253-3ovqhypt	83	3	years	year	NNS
cord-262253-3ovqhypt	83	4	,	,	,
cord-262253-3ovqhypt	83	5	there	there	EX
cord-262253-3ovqhypt	83	6	has	have	VBZ
cord-262253-3ovqhypt	83	7	been	be	VBN
cord-262253-3ovqhypt	83	8	increasing	increase	VBG
cord-262253-3ovqhypt	83	9	evidence	evidence	NN
cord-262253-3ovqhypt	83	10	of	of	IN
cord-262253-3ovqhypt	83	11	neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	83	12	's	's	POS
cord-262253-3ovqhypt	83	13	role	role	NN
cord-262253-3ovqhypt	83	14	in	in	IN
cord-262253-3ovqhypt	83	15	AD	ad	NN
cord-262253-3ovqhypt	83	16	.	.	.
cord-262253-3ovqhypt	84	1	In	in	IN
cord-262253-3ovqhypt	84	2	addition	addition	NN
cord-262253-3ovqhypt	84	3	to	to	IN
cord-262253-3ovqhypt	84	4	Aβ	Aβ	NNP
cord-262253-3ovqhypt	84	5	plaques	plaque	NNS
cord-262253-3ovqhypt	84	6	and	and	CC
cord-262253-3ovqhypt	84	7	NFTs	nft	NNS
cord-262253-3ovqhypt	84	8	,	,	,
cord-262253-3ovqhypt	84	9	markers	marker	NNS
cord-262253-3ovqhypt	84	10	of	of	IN
cord-262253-3ovqhypt	84	11	sustained	sustained	JJ
cord-262253-3ovqhypt	84	12	inflammation	inflammation	NN
cord-262253-3ovqhypt	84	13	and	and	CC
cord-262253-3ovqhypt	84	14	microglial	microglial	JJ
cord-262253-3ovqhypt	84	15	activation	activation	NN
cord-262253-3ovqhypt	84	16	have	have	VBP
cord-262253-3ovqhypt	84	17	repeatedly	repeatedly	RB
cord-262253-3ovqhypt	84	18	been	be	VBN
cord-262253-3ovqhypt	84	19	found	find	VBN
cord-262253-3ovqhypt	84	20	in	in	IN
cord-262253-3ovqhypt	84	21	AD	ad	NN
cord-262253-3ovqhypt	84	22	brain	brain	NN
cord-262253-3ovqhypt	84	23	samples	sample	NNS
cord-262253-3ovqhypt	84	24	[	[	-LRB-
cord-262253-3ovqhypt	84	25	39	39	CD
cord-262253-3ovqhypt	84	26	]	]	-RRB-
cord-262253-3ovqhypt	84	27	.	.	.
cord-262253-3ovqhypt	85	1	The	the	DT
cord-262253-3ovqhypt	85	2	cytokines	cytokine	NNS
cord-262253-3ovqhypt	85	3	interleukin	interleukin	NN
cord-262253-3ovqhypt	85	4	1	1	CD
cord-262253-3ovqhypt	85	5	and	and	CC
cord-262253-3ovqhypt	85	6	interleukin	interleukin	NN
cord-262253-3ovqhypt	85	7	6	6	CD
cord-262253-3ovqhypt	85	8	are	be	VBP
cord-262253-3ovqhypt	85	9	especially	especially	RB
cord-262253-3ovqhypt	85	10	elevated	elevate	VBN
cord-262253-3ovqhypt	85	11	[	[	-LRB-
cord-262253-3ovqhypt	85	12	44	44	CD
cord-262253-3ovqhypt	85	13	]	]	-RRB-
cord-262253-3ovqhypt	85	14	.	.	.
cord-262253-3ovqhypt	86	1	One	one	CD
cord-262253-3ovqhypt	86	2	source	source	NN
cord-262253-3ovqhypt	86	3	of	of	IN
cord-262253-3ovqhypt	86	4	the	the	DT
cord-262253-3ovqhypt	86	5	neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	86	6	in	in	IN
cord-262253-3ovqhypt	86	7	AD	ad	NN
cord-262253-3ovqhypt	86	8	patients	patient	NNS
cord-262253-3ovqhypt	86	9	could	could	MD
cord-262253-3ovqhypt	86	10	be	be	VB
cord-262253-3ovqhypt	86	11	the	the	DT
cord-262253-3ovqhypt	86	12	response	response	NN
cord-262253-3ovqhypt	86	13	to	to	IN
cord-262253-3ovqhypt	86	14	invading	invade	VBG
cord-262253-3ovqhypt	86	15	microorganisms	microorganism	NNS
cord-262253-3ovqhypt	86	16	and	and	CC
cord-262253-3ovqhypt	86	17	viruses	virus	NNS
cord-262253-3ovqhypt	86	18	.	.	.
cord-262253-3ovqhypt	87	1	In	in	IN
cord-262253-3ovqhypt	87	2	fact	fact	NN
cord-262253-3ovqhypt	87	3	,	,	,
cord-262253-3ovqhypt	87	4	researchers	researcher	NNS
cord-262253-3ovqhypt	87	5	have	have	VBP
cord-262253-3ovqhypt	87	6	found	find	VBN
cord-262253-3ovqhypt	87	7	evidence	evidence	NN
cord-262253-3ovqhypt	87	8	pointing	point	VBG
cord-262253-3ovqhypt	87	9	to	to	IN
cord-262253-3ovqhypt	87	10	the	the	DT
cord-262253-3ovqhypt	87	11	presence	presence	NN
cord-262253-3ovqhypt	87	12	of	of	IN
cord-262253-3ovqhypt	87	13	pathogens	pathogen	NNS
cord-262253-3ovqhypt	87	14	,	,	,
cord-262253-3ovqhypt	87	15	such	such	JJ
cord-262253-3ovqhypt	87	16	as	as	IN
cord-262253-3ovqhypt	87	17	viruses	virus	NNS
cord-262253-3ovqhypt	87	18	,	,	,
cord-262253-3ovqhypt	87	19	bacteria	bacteria	NNS
cord-262253-3ovqhypt	87	20	and	and	CC
cord-262253-3ovqhypt	87	21	fungi	fungus	NNS
cord-262253-3ovqhypt	87	22	,	,	,
cord-262253-3ovqhypt	87	23	in	in	IN
cord-262253-3ovqhypt	87	24	AD	ad	NN
cord-262253-3ovqhypt	87	25	brains	brain	NNS
cord-262253-3ovqhypt	87	26	[	[	-LRB-
cord-262253-3ovqhypt	87	27	45	45	CD
cord-262253-3ovqhypt	87	28	]	]	-RRB-
cord-262253-3ovqhypt	87	29	[	[	-LRB-
cord-262253-3ovqhypt	87	30	46	46	CD
cord-262253-3ovqhypt	87	31	]	]	-RRB-
cord-262253-3ovqhypt	87	32	[	[	-LRB-
cord-262253-3ovqhypt	87	33	47	47	CD
cord-262253-3ovqhypt	87	34	]	]	-RRB-
cord-262253-3ovqhypt	88	1	[	[	-LRB-
cord-262253-3ovqhypt	88	2	48	48	CD
cord-262253-3ovqhypt	88	3	]	]	-RRB-
cord-262253-3ovqhypt	89	1	[	[	-LRB-
cord-262253-3ovqhypt	89	2	49	49	CD
cord-262253-3ovqhypt	89	3	]	]	-RRB-
cord-262253-3ovqhypt	89	4	[	[	-LRB-
cord-262253-3ovqhypt	89	5	50	50	CD
cord-262253-3ovqhypt	89	6	]	]	-RRB-
cord-262253-3ovqhypt	89	7	.	.	.
cord-262253-3ovqhypt	90	1	This	this	DT
cord-262253-3ovqhypt	90	2	notion	notion	NN
cord-262253-3ovqhypt	90	3	draws	draw	VBZ
cord-262253-3ovqhypt	90	4	parallels	parallel	NNS
cord-262253-3ovqhypt	90	5	with	with	IN
cord-262253-3ovqhypt	90	6	the	the	DT
cord-262253-3ovqhypt	90	7	measles	measle	NNS
cord-262253-3ovqhypt	90	8	virus	virus	NN
cord-262253-3ovqhypt	90	9	,	,	,
cord-262253-3ovqhypt	90	10	which	which	WDT
cord-262253-3ovqhypt	90	11	can	can	MD
cord-262253-3ovqhypt	90	12	lead	lead	VB
cord-262253-3ovqhypt	90	13	to	to	IN
cord-262253-3ovqhypt	90	14	the	the	DT
cord-262253-3ovqhypt	90	15	development	development	NN
cord-262253-3ovqhypt	90	16	of	of	IN
cord-262253-3ovqhypt	90	17	the	the	DT
cord-262253-3ovqhypt	90	18	neurological	neurological	JJ
cord-262253-3ovqhypt	90	19	disease	disease	NN
cord-262253-3ovqhypt	90	20	known	know	VBN
cord-262253-3ovqhypt	90	21	as	as	IN
cord-262253-3ovqhypt	90	22	subacute	subacute	JJ
cord-262253-3ovqhypt	90	23	sclerosing	sclerosing	NN
cord-262253-3ovqhypt	90	24	panencephalitis	panencephalitis	NNP
cord-262253-3ovqhypt	90	25	[	[	-LRB-
cord-262253-3ovqhypt	90	26	51	51	CD
cord-262253-3ovqhypt	90	27	]	]	-RRB-
cord-262253-3ovqhypt	90	28	.	.	.
cord-262253-3ovqhypt	91	1	These	these	DT
cord-262253-3ovqhypt	91	2	findings	finding	NNS
cord-262253-3ovqhypt	91	3	include	include	VBP
cord-262253-3ovqhypt	91	4	the	the	DT
cord-262253-3ovqhypt	91	5	identification	identification	NN
cord-262253-3ovqhypt	91	6	of	of	IN
cord-262253-3ovqhypt	91	7	viral	viral	JJ
cord-262253-3ovqhypt	91	8	[	[	-LRB-
cord-262253-3ovqhypt	91	9	52	52	CD
cord-262253-3ovqhypt	91	10	]	]	-RRB-
cord-262253-3ovqhypt	91	11	and	and	CC
cord-262253-3ovqhypt	91	12	bacterial	bacterial	JJ
cord-262253-3ovqhypt	91	13	DNA	dna	NN
cord-262253-3ovqhypt	91	14	in	in	IN
cord-262253-3ovqhypt	91	15	post	post	JJ
cord-262253-3ovqhypt	91	16	-	-	JJ
cord-262253-3ovqhypt	91	17	mortem	mortem	JJ
cord-262253-3ovqhypt	91	18	brain	brain	NN
cord-262253-3ovqhypt	91	19	samples	sample	NNS
cord-262253-3ovqhypt	91	20	,	,	,
cord-262253-3ovqhypt	91	21	and	and	CC
cord-262253-3ovqhypt	91	22	the	the	DT
cord-262253-3ovqhypt	91	23	detection	detection	NN
cord-262253-3ovqhypt	91	24	of	of	IN
cord-262253-3ovqhypt	91	25	pathogens	pathogen	NNS
cord-262253-3ovqhypt	91	26	[	[	-LRB-
cord-262253-3ovqhypt	91	27	53	53	CD
cord-262253-3ovqhypt	91	28	]	]	-RRB-
cord-262253-3ovqhypt	91	29	and/or	and/or	CC
cord-262253-3ovqhypt	91	30	their	-PRON-	PRP$
cord-262253-3ovqhypt	91	31	respective	respective	JJ
cord-262253-3ovqhypt	91	32	antibodies	antibody	NNS
cord-262253-3ovqhypt	91	33	[	[	-LRB-
cord-262253-3ovqhypt	91	34	54	54	CD
cord-262253-3ovqhypt	91	35	]	]	-RRB-
cord-262253-3ovqhypt	91	36	in	in	IN
cord-262253-3ovqhypt	91	37	the	the	DT
cord-262253-3ovqhypt	91	38	serum	serum	NN
cord-262253-3ovqhypt	91	39	or	or	CC
cord-262253-3ovqhypt	91	40	cerebrospinal	cerebrospinal	JJ
cord-262253-3ovqhypt	91	41	fluid	fluid	NN
cord-262253-3ovqhypt	91	42	of	of	IN
cord-262253-3ovqhypt	91	43	patients	patient	NNS
cord-262253-3ovqhypt	91	44	.	.	.
cord-262253-3ovqhypt	92	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	92	2	,	,	,
cord-262253-3ovqhypt	92	3	detection	detection	NN
cord-262253-3ovqhypt	92	4	of	of	IN
cord-262253-3ovqhypt	92	5	lipopolysaccharide	lipopolysaccharide	NN
cord-262253-3ovqhypt	92	6	is	be	VBZ
cord-262253-3ovqhypt	92	7	commonly	commonly	RB
cord-262253-3ovqhypt	92	8	used	use	VBN
cord-262253-3ovqhypt	92	9	by	by	IN
cord-262253-3ovqhypt	92	10	researchers	researcher	NNS
cord-262253-3ovqhypt	92	11	to	to	TO
cord-262253-3ovqhypt	92	12	measure	measure	VB
cord-262253-3ovqhypt	92	13	the	the	DT
cord-262253-3ovqhypt	92	14	presence	presence	NN
cord-262253-3ovqhypt	92	15	of	of	IN
cord-262253-3ovqhypt	92	16	Gram	gram	NN
cord-262253-3ovqhypt	92	17	-	-	HYPH
cord-262253-3ovqhypt	92	18	negative	negative	JJ
cord-262253-3ovqhypt	92	19	bacteria	bacteria	NNS
cord-262253-3ovqhypt	92	20	,	,	,
cord-262253-3ovqhypt	92	21	like	like	IN
cord-262253-3ovqhypt	92	22	P.	P.	NNP
cord-262253-3ovqhypt	92	23	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	92	24	specifically	specifically	RB
cord-262253-3ovqhypt	92	25	,	,	,
cord-262253-3ovqhypt	92	26	as	as	IN
cord-262253-3ovqhypt	92	27	it	-PRON-	PRP
cord-262253-3ovqhypt	92	28	is	be	VBZ
cord-262253-3ovqhypt	92	29	found	find	VBN
cord-262253-3ovqhypt	92	30	in	in	IN
cord-262253-3ovqhypt	92	31	their	-PRON-	PRP$
cord-262253-3ovqhypt	92	32	cell	cell	NN
cord-262253-3ovqhypt	92	33	walls	wall	NNS
cord-262253-3ovqhypt	92	34	and	and	CC
cord-262253-3ovqhypt	92	35	can	can	MD
cord-262253-3ovqhypt	92	36	stimulate	stimulate	VB
cord-262253-3ovqhypt	92	37	an	an	DT
cord-262253-3ovqhypt	92	38	inflammatory	inflammatory	JJ
cord-262253-3ovqhypt	92	39	response	response	NN
cord-262253-3ovqhypt	92	40	in	in	IN
cord-262253-3ovqhypt	92	41	the	the	DT
cord-262253-3ovqhypt	92	42	immune	immune	JJ
cord-262253-3ovqhypt	92	43	cells	cell	NNS
cord-262253-3ovqhypt	92	44	[	[	-LRB-
cord-262253-3ovqhypt	92	45	42	42	CD
cord-262253-3ovqhypt	92	46	]	]	-RRB-
cord-262253-3ovqhypt	92	47	.	.	.
cord-262253-3ovqhypt	93	1	Herpes	herpes	NN
cord-262253-3ovqhypt	93	2	simplex	simplex	NN
cord-262253-3ovqhypt	93	3	virus-1	virus-1	NN
cord-262253-3ovqhypt	93	4	(	(	-LRB-
cord-262253-3ovqhypt	93	5	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	93	6	)	)	-RRB-
cord-262253-3ovqhypt	93	7	[	[	-LRB-
cord-262253-3ovqhypt	94	1	52	52	CD
cord-262253-3ovqhypt	94	2	,	,	,
cord-262253-3ovqhypt	94	3	[	[	-LRB-
cord-262253-3ovqhypt	94	4	55	55	CD
cord-262253-3ovqhypt	94	5	]	]	-RRB-
cord-262253-3ovqhypt	94	6	[	[	-LRB-
cord-262253-3ovqhypt	94	7	56	56	CD
cord-262253-3ovqhypt	94	8	]	]	-RRB-
cord-262253-3ovqhypt	94	9	[	[	-LRB-
cord-262253-3ovqhypt	94	10	57	57	CD
cord-262253-3ovqhypt	94	11	]	]	-RRB-
cord-262253-3ovqhypt	95	1	[	[	-LRB-
cord-262253-3ovqhypt	95	2	58	58	CD
cord-262253-3ovqhypt	95	3	]	]	-RRB-
cord-262253-3ovqhypt	95	4	was	be	VBD
cord-262253-3ovqhypt	95	5	the	the	DT
cord-262253-3ovqhypt	95	6	first	first	JJ
cord-262253-3ovqhypt	95	7	pathogen	pathogen	NN
cord-262253-3ovqhypt	95	8	found	find	VBN
cord-262253-3ovqhypt	95	9	to	to	TO
cord-262253-3ovqhypt	95	10	be	be	VB
cord-262253-3ovqhypt	95	11	present	present	JJ
cord-262253-3ovqhypt	95	12	in	in	IN
cord-262253-3ovqhypt	95	13	AD	ad	NN
cord-262253-3ovqhypt	95	14	brain	brain	NN
cord-262253-3ovqhypt	95	15	samples	sample	NNS
cord-262253-3ovqhypt	95	16	[	[	-LRB-
cord-262253-3ovqhypt	95	17	59	59	CD
cord-262253-3ovqhypt	95	18	]	]	-RRB-
cord-262253-3ovqhypt	95	19	,	,	,
cord-262253-3ovqhypt	95	20	and	and	CC
cord-262253-3ovqhypt	95	21	it	-PRON-	PRP
cord-262253-3ovqhypt	95	22	thereafter	thereafter	RB
cord-262253-3ovqhypt	95	23	became	become	VBD
cord-262253-3ovqhypt	95	24	the	the	DT
cord-262253-3ovqhypt	95	25	most	most	RBS
cord-262253-3ovqhypt	95	26	widely	widely	RB
cord-262253-3ovqhypt	95	27	-	-	HYPH
cord-262253-3ovqhypt	95	28	researched	research	VBN
cord-262253-3ovqhypt	95	29	pathogen	pathogen	NN
cord-262253-3ovqhypt	95	30	regarding	regard	VBG
cord-262253-3ovqhypt	95	31	the	the	DT
cord-262253-3ovqhypt	95	32	linkage	linkage	NN
cord-262253-3ovqhypt	95	33	between	between	IN
cord-262253-3ovqhypt	95	34	viral	viral	JJ
cord-262253-3ovqhypt	95	35	infection	infection	NN
cord-262253-3ovqhypt	95	36	and	and	CC
cord-262253-3ovqhypt	95	37	AD	ad	NN
cord-262253-3ovqhypt	95	38	.	.	.
cord-262253-3ovqhypt	96	1	Since	since	IN
cord-262253-3ovqhypt	96	2	then	then	RB
cord-262253-3ovqhypt	96	3	,	,	,
cord-262253-3ovqhypt	96	4	other	other	JJ
cord-262253-3ovqhypt	96	5	viruses	virus	NNS
cord-262253-3ovqhypt	96	6	have	have	VBP
cord-262253-3ovqhypt	96	7	been	be	VBN
cord-262253-3ovqhypt	96	8	identified	identify	VBN
cord-262253-3ovqhypt	96	9	in	in	IN
cord-262253-3ovqhypt	96	10	leading	lead	VBG
cord-262253-3ovqhypt	96	11	to	to	IN
cord-262253-3ovqhypt	96	12	the	the	DT
cord-262253-3ovqhypt	96	13	progression	progression	NN
cord-262253-3ovqhypt	96	14	of	of	IN
cord-262253-3ovqhypt	96	15	AD	ad	NN
cord-262253-3ovqhypt	96	16	,	,	,
cord-262253-3ovqhypt	96	17	including	include	VBG
cord-262253-3ovqhypt	96	18	human	human	JJ
cord-262253-3ovqhypt	96	19	cytomegalovirus	cytomegalovirus	NN
cord-262253-3ovqhypt	96	20	[	[	-LRB-
cord-262253-3ovqhypt	96	21	54	54	CD
cord-262253-3ovqhypt	96	22	]	]	-RRB-
cord-262253-3ovqhypt	96	23	and	and	CC
cord-262253-3ovqhypt	96	24	Epstein	Epstein	NNP
cord-262253-3ovqhypt	96	25	Barr	Barr	NNP
cord-262253-3ovqhypt	96	26	Virus	Virus	NNP
cord-262253-3ovqhypt	96	27	[	[	-LRB-
cord-262253-3ovqhypt	96	28	60	60	CD
cord-262253-3ovqhypt	96	29	]	]	-RRB-
cord-262253-3ovqhypt	96	30	.	.	.
cord-262253-3ovqhypt	97	1	A	a	DT
cord-262253-3ovqhypt	97	2	recent	recent	JJ
cord-262253-3ovqhypt	97	3	2018	2018	CD
cord-262253-3ovqhypt	97	4	study	study	NN
cord-262253-3ovqhypt	97	5	found	find	VBD
cord-262253-3ovqhypt	97	6	that	that	IN
cord-262253-3ovqhypt	97	7	,	,	,
cord-262253-3ovqhypt	97	8	in	in	IN
cord-262253-3ovqhypt	97	9	addition	addition	NN
cord-262253-3ovqhypt	97	10	to	to	IN
cord-262253-3ovqhypt	97	11	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	97	12	,	,	,
cord-262253-3ovqhypt	97	13	herpesvirus	herpesvirus	NN
cord-262253-3ovqhypt	97	14	types	type	NNS
cord-262253-3ovqhypt	97	15	HHV-6	HHV-6	NNP
cord-262253-3ovqhypt	97	16	[	[	-LRB-
cord-262253-3ovqhypt	97	17	46	46	CD
cord-262253-3ovqhypt	97	18	,	,	,
cord-262253-3ovqhypt	97	19	47	47	CD
cord-262253-3ovqhypt	97	20	]	]	-RRB-
cord-262253-3ovqhypt	97	21	and	and	CC
cord-262253-3ovqhypt	97	22	HHV-7	HHV-7	NNP
cord-262253-3ovqhypt	97	23	were	be	VBD
cord-262253-3ovqhypt	97	24	highly	highly	RB
cord-262253-3ovqhypt	97	25	present	present	JJ
cord-262253-3ovqhypt	97	26	in	in	IN
cord-262253-3ovqhypt	97	27	AD	ad	NN
cord-262253-3ovqhypt	97	28	patients	patient	NNS
cord-262253-3ovqhypt	97	29	[	[	-LRB-
cord-262253-3ovqhypt	97	30	61	61	CD
cord-262253-3ovqhypt	97	31	]	]	-RRB-
cord-262253-3ovqhypt	97	32	.	.	.
cord-262253-3ovqhypt	98	1	In	in	IN
cord-262253-3ovqhypt	98	2	this	this	DT
cord-262253-3ovqhypt	98	3	study	study	NN
cord-262253-3ovqhypt	98	4	,	,	,
cord-262253-3ovqhypt	98	5	by	by	IN
cord-262253-3ovqhypt	98	6	Readhead	Readhead	NNP
cord-262253-3ovqhypt	98	7	et	et	NNP
cord-262253-3ovqhypt	98	8	al	al	NNP
cord-262253-3ovqhypt	98	9	.	.	NNP
cord-262253-3ovqhypt	98	10	,	,	,
cord-262253-3ovqhypt	98	11	HHV-6	HHV-6	NNP
cord-262253-3ovqhypt	98	12	and	and	CC
cord-262253-3ovqhypt	98	13	HHV-7	HHV-7	NNP
cord-262253-3ovqhypt	98	14	were	be	VBD
cord-262253-3ovqhypt	98	15	also	also	RB
cord-262253-3ovqhypt	98	16	observed	observe	VBN
cord-262253-3ovqhypt	98	17	to	to	TO
cord-262253-3ovqhypt	98	18	be	be	VB
cord-262253-3ovqhypt	98	19	involved	involve	VBN
cord-262253-3ovqhypt	98	20	in	in	IN
cord-262253-3ovqhypt	98	21	regulatory	regulatory	JJ
cord-262253-3ovqhypt	98	22	processes	process	NNS
cord-262253-3ovqhypt	98	23	critical	critical	JJ
cord-262253-3ovqhypt	98	24	to	to	IN
cord-262253-3ovqhypt	98	25	characteristic	characteristic	JJ
cord-262253-3ovqhypt	98	26	features	feature	NNS
cord-262253-3ovqhypt	98	27	of	of	IN
cord-262253-3ovqhypt	98	28	the	the	DT
cord-262253-3ovqhypt	98	29	disease	disease	NN
cord-262253-3ovqhypt	98	30	[	[	-LRB-
cord-262253-3ovqhypt	98	31	61	61	CD
cord-262253-3ovqhypt	98	32	]	]	-RRB-
cord-262253-3ovqhypt	98	33	.	.	.
cord-262253-3ovqhypt	99	1	Bacterial	bacterial	JJ
cord-262253-3ovqhypt	99	2	infection	infection	NN
cord-262253-3ovqhypt	99	3	has	have	VBZ
cord-262253-3ovqhypt	99	4	likewise	likewise	RB
cord-262253-3ovqhypt	99	5	been	be	VBN
cord-262253-3ovqhypt	99	6	associated	associate	VBN
cord-262253-3ovqhypt	99	7	with	with	IN
cord-262253-3ovqhypt	99	8	the	the	DT
cord-262253-3ovqhypt	99	9	progression	progression	NN
cord-262253-3ovqhypt	99	10	of	of	IN
cord-262253-3ovqhypt	99	11	AD	ad	NN
cord-262253-3ovqhypt	99	12	.	.	.
cord-262253-3ovqhypt	100	1	The	the	DT
cord-262253-3ovqhypt	100	2	presence	presence	NN
cord-262253-3ovqhypt	100	3	of	of	IN
cord-262253-3ovqhypt	100	4	bacteria	bacteria	NNS
cord-262253-3ovqhypt	100	5	in	in	IN
cord-262253-3ovqhypt	100	6	the	the	DT
cord-262253-3ovqhypt	100	7	brain	brain	NN
cord-262253-3ovqhypt	100	8	has	have	VBZ
cord-262253-3ovqhypt	100	9	been	be	VBN
cord-262253-3ovqhypt	100	10	determined	determine	VBN
cord-262253-3ovqhypt	100	11	in	in	IN
cord-262253-3ovqhypt	100	12	previous	previous	JJ
cord-262253-3ovqhypt	100	13	studies	study	NNS
cord-262253-3ovqhypt	100	14	,	,	,
cord-262253-3ovqhypt	100	15	suggesting	suggest	VBG
cord-262253-3ovqhypt	100	16	the	the	DT
cord-262253-3ovqhypt	100	17	presence	presence	NN
cord-262253-3ovqhypt	100	18	of	of	IN
cord-262253-3ovqhypt	100	19	a	a	DT
cord-262253-3ovqhypt	100	20	brain	brain	NN
cord-262253-3ovqhypt	100	21	microbiome	microbiome	NN
cord-262253-3ovqhypt	100	22	[	[	-LRB-
cord-262253-3ovqhypt	100	23	62	62	CD
cord-262253-3ovqhypt	100	24	]	]	-RRB-
cord-262253-3ovqhypt	100	25	[	[	-LRB-
cord-262253-3ovqhypt	100	26	63	63	CD
cord-262253-3ovqhypt	100	27	]	]	-RRB-
cord-262253-3ovqhypt	100	28	[	[	-LRB-
cord-262253-3ovqhypt	100	29	64	64	CD
cord-262253-3ovqhypt	100	30	]	]	-RRB-
cord-262253-3ovqhypt	100	31	.	.	.
cord-262253-3ovqhypt	101	1	Even	even	RB
cord-262253-3ovqhypt	101	2	though	though	IN
cord-262253-3ovqhypt	101	3	bacterial	bacterial	JJ
cord-262253-3ovqhypt	101	4	presence	presence	NN
cord-262253-3ovqhypt	101	5	has	have	VBZ
cord-262253-3ovqhypt	101	6	been	be	VBN
cord-262253-3ovqhypt	101	7	seen	see	VBN
cord-262253-3ovqhypt	101	8	in	in	IN
cord-262253-3ovqhypt	101	9	the	the	DT
cord-262253-3ovqhypt	101	10	brains	brain	NNS
cord-262253-3ovqhypt	101	11	of	of	IN
cord-262253-3ovqhypt	101	12	healthy	healthy	JJ
cord-262253-3ovqhypt	101	13	individuals	individual	NNS
cord-262253-3ovqhypt	101	14	,	,	,
cord-262253-3ovqhypt	101	15	tissue	tissue	NN
cord-262253-3ovqhypt	101	16	samples	sample	NNS
cord-262253-3ovqhypt	101	17	from	from	IN
cord-262253-3ovqhypt	101	18	AD	ad	NN
cord-262253-3ovqhypt	101	19	brains	brain	NNS
cord-262253-3ovqhypt	101	20	have	have	VBP
cord-262253-3ovqhypt	101	21	greater	great	JJR
cord-262253-3ovqhypt	101	22	levels	level	NNS
cord-262253-3ovqhypt	101	23	of	of	IN
cord-262253-3ovqhypt	101	24	bacterial	bacterial	JJ
cord-262253-3ovqhypt	101	25	species	specie	NNS
cord-262253-3ovqhypt	101	26	[	[	-LRB-
cord-262253-3ovqhypt	101	27	64	64	CD
cord-262253-3ovqhypt	101	28	]	]	-RRB-
cord-262253-3ovqhypt	101	29	,	,	,
cord-262253-3ovqhypt	101	30	indicating	indicate	VBG
cord-262253-3ovqhypt	101	31	a	a	DT
cord-262253-3ovqhypt	101	32	greater	great	JJR
cord-262253-3ovqhypt	101	33	level	level	NN
cord-262253-3ovqhypt	101	34	of	of	IN
cord-262253-3ovqhypt	101	35	infiltration	infiltration	NN
cord-262253-3ovqhypt	101	36	.	.	.
cord-262253-3ovqhypt	102	1	Chlamydia	Chlamydia	NNP
cord-262253-3ovqhypt	102	2	pneumoniae	pneumoniae	NN
cord-262253-3ovqhypt	102	3	is	be	VBZ
cord-262253-3ovqhypt	102	4	the	the	DT
cord-262253-3ovqhypt	102	5	most	most	RBS
cord-262253-3ovqhypt	102	6	widely	widely	RB
cord-262253-3ovqhypt	102	7	-	-	HYPH
cord-262253-3ovqhypt	102	8	studied	study	VBN
cord-262253-3ovqhypt	102	9	bacteria	bacteria	NNS
cord-262253-3ovqhypt	102	10	regarding	regard	VBG
cord-262253-3ovqhypt	102	11	association	association	NN
cord-262253-3ovqhypt	102	12	to	to	IN
cord-262253-3ovqhypt	102	13	AD	AD	NNP
cord-262253-3ovqhypt	102	14	[	[	-LRB-
cord-262253-3ovqhypt	102	15	25	25	CD
cord-262253-3ovqhypt	102	16	,	,	,
cord-262253-3ovqhypt	102	17	49	49	CD
cord-262253-3ovqhypt	102	18	]	]	-RRB-
cord-262253-3ovqhypt	102	19	.	.	.
cord-262253-3ovqhypt	103	1	A	a	DT
cord-262253-3ovqhypt	103	2	clinical	clinical	JJ
cord-262253-3ovqhypt	103	3	investigation	investigation	NN
cord-262253-3ovqhypt	103	4	,	,	,
cord-262253-3ovqhypt	103	5	made	make	VBN
cord-262253-3ovqhypt	103	6	up	up	RP
cord-262253-3ovqhypt	103	7	of	of	IN
cord-262253-3ovqhypt	103	8	a	a	DT
cord-262253-3ovqhypt	103	9	healthy	healthy	JJ
cord-262253-3ovqhypt	103	10	control	control	NN
cord-262253-3ovqhypt	103	11	group	group	NN
cord-262253-3ovqhypt	103	12	and	and	CC
cord-262253-3ovqhypt	103	13	an	an	DT
cord-262253-3ovqhypt	103	14	AD	ad	NN
cord-262253-3ovqhypt	103	15	group	group	NN
cord-262253-3ovqhypt	103	16	,	,	,
cord-262253-3ovqhypt	103	17	detected	detect	VBD
cord-262253-3ovqhypt	103	18	C.	C.	NNP
cord-262253-3ovqhypt	103	19	pneumoniae	pneumoniae	NN
cord-262253-3ovqhypt	103	20	in	in	IN
cord-262253-3ovqhypt	103	21	90	90	CD
cord-262253-3ovqhypt	103	22	%	%	NN
cord-262253-3ovqhypt	103	23	of	of	IN
cord-262253-3ovqhypt	103	24	the	the	DT
cord-262253-3ovqhypt	103	25	AD	ad	NN
cord-262253-3ovqhypt	103	26	patients	patient	NNS
cord-262253-3ovqhypt	103	27	,	,	,
cord-262253-3ovqhypt	103	28	whereas	whereas	IN
cord-262253-3ovqhypt	103	29	the	the	DT
cord-262253-3ovqhypt	103	30	control	control	NN
cord-262253-3ovqhypt	103	31	group	group	NN
cord-262253-3ovqhypt	103	32	were	be	VBD
cord-262253-3ovqhypt	103	33	all	all	DT
cord-262253-3ovqhypt	103	34	negative	negative	JJ
cord-262253-3ovqhypt	103	35	[	[	-LRB-
cord-262253-3ovqhypt	103	36	53	53	CD
cord-262253-3ovqhypt	103	37	]	]	-RRB-
cord-262253-3ovqhypt	103	38	.	.	.
cord-262253-3ovqhypt	104	1	Escherichia	escherichia	NN
cord-262253-3ovqhypt	104	2	coli	coli	NNS
cord-262253-3ovqhypt	104	3	,	,	,
cord-262253-3ovqhypt	104	4	likewise	likewise	RB
cord-262253-3ovqhypt	104	5	identified	identify	VBN
cord-262253-3ovqhypt	104	6	in	in	IN
cord-262253-3ovqhypt	104	7	AD	ad	NN
cord-262253-3ovqhypt	104	8	brains	brain	NNS
cord-262253-3ovqhypt	104	9	[	[	-LRB-
cord-262253-3ovqhypt	104	10	65	65	CD
cord-262253-3ovqhypt	104	11	]	]	-RRB-
cord-262253-3ovqhypt	104	12	,	,	,
cord-262253-3ovqhypt	104	13	has	have	VBZ
cord-262253-3ovqhypt	104	14	been	be	VBN
cord-262253-3ovqhypt	104	15	found	find	VBN
cord-262253-3ovqhypt	104	16	to	to	TO
cord-262253-3ovqhypt	104	17	be	be	VB
cord-262253-3ovqhypt	104	18	capable	capable	JJ
cord-262253-3ovqhypt	104	19	of	of	IN
cord-262253-3ovqhypt	104	20	synthesizing	synthesize	VBG
cord-262253-3ovqhypt	104	21	extracellular	extracellular	JJ
cord-262253-3ovqhypt	104	22	amyloid	amyloid	NN
cord-262253-3ovqhypt	104	23	[	[	-LRB-
cord-262253-3ovqhypt	104	24	66	66	CD
cord-262253-3ovqhypt	104	25	]	]	-RRB-
cord-262253-3ovqhypt	104	26	.	.	.
cord-262253-3ovqhypt	105	1	Stains	stain	NNS
cord-262253-3ovqhypt	105	2	such	such	JJ
cord-262253-3ovqhypt	105	3	as	as	IN
cord-262253-3ovqhypt	105	4	Borrelia	Borrelia	NNP
cord-262253-3ovqhypt	105	5	burgdorferi	burgdorferi	NN
cord-262253-3ovqhypt	105	6	[	[	-LRB-
cord-262253-3ovqhypt	105	7	67	67	CD
cord-262253-3ovqhypt	105	8	]	]	-RRB-
cord-262253-3ovqhypt	105	9	,	,	,
cord-262253-3ovqhypt	105	10	spirochetes	spirochete	NNS
cord-262253-3ovqhypt	105	11	[	[	-LRB-
cord-262253-3ovqhypt	105	12	48	48	CD
cord-262253-3ovqhypt	105	13	]	]	-RRB-
cord-262253-3ovqhypt	105	14	,	,	,
cord-262253-3ovqhypt	105	15	and	and	CC
cord-262253-3ovqhypt	105	16	Porphyromonas	Porphyromonas	NNP
cord-262253-3ovqhypt	105	17	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	105	18	,	,	,
cord-262253-3ovqhypt	105	19	a	a	DT
cord-262253-3ovqhypt	105	20	pathogen	pathogen	NN
cord-262253-3ovqhypt	105	21	commonly	commonly	RB
cord-262253-3ovqhypt	105	22	linked	link	VBN
cord-262253-3ovqhypt	105	23	to	to	IN
cord-262253-3ovqhypt	105	24	chronic	chronic	JJ
cord-262253-3ovqhypt	105	25	periodontitis	periodontitis	NN
cord-262253-3ovqhypt	105	26	,	,	,
cord-262253-3ovqhypt	105	27	have	have	VBP
cord-262253-3ovqhypt	105	28	also	also	RB
cord-262253-3ovqhypt	105	29	been	be	VBN
cord-262253-3ovqhypt	105	30	identified	identify	VBN
cord-262253-3ovqhypt	105	31	in	in	IN
cord-262253-3ovqhypt	105	32	AD	ad	NN
cord-262253-3ovqhypt	105	33	brain	brain	NN
cord-262253-3ovqhypt	105	34	samples	sample	NNS
cord-262253-3ovqhypt	105	35	[	[	-LRB-
cord-262253-3ovqhypt	105	36	68	68	CD
cord-262253-3ovqhypt	105	37	]	]	-RRB-
cord-262253-3ovqhypt	105	38	.	.	.
cord-262253-3ovqhypt	106	1	Interestingly	interestingly	RB
cord-262253-3ovqhypt	106	2	,	,	,
cord-262253-3ovqhypt	106	3	fungal	fungal	JJ
cord-262253-3ovqhypt	106	4	infection	infection	NN
cord-262253-3ovqhypt	106	5	from	from	IN
cord-262253-3ovqhypt	106	6	species	specie	NNS
cord-262253-3ovqhypt	106	7	primarily	primarily	RB
cord-262253-3ovqhypt	106	8	associated	associate	VBN
cord-262253-3ovqhypt	106	9	with	with	IN
cord-262253-3ovqhypt	106	10	periodontal	periodontal	JJ
cord-262253-3ovqhypt	106	11	disease	disease	NN
cord-262253-3ovqhypt	106	12	has	have	VBZ
cord-262253-3ovqhypt	106	13	recently	recently	RB
cord-262253-3ovqhypt	106	14	been	be	VBN
cord-262253-3ovqhypt	106	15	suggested	suggest	VBN
cord-262253-3ovqhypt	106	16	to	to	TO
cord-262253-3ovqhypt	106	17	be	be	VB
cord-262253-3ovqhypt	106	18	involved	involve	VBN
cord-262253-3ovqhypt	106	19	in	in	IN
cord-262253-3ovqhypt	106	20	AD	ad	NN
cord-262253-3ovqhypt	106	21	progression	progression	NN
cord-262253-3ovqhypt	106	22	.	.	.
cord-262253-3ovqhypt	107	1	Researchers	researcher	NNS
cord-262253-3ovqhypt	107	2	in	in	IN
cord-262253-3ovqhypt	107	3	a	a	DT
cord-262253-3ovqhypt	107	4	2014	2014	CD
cord-262253-3ovqhypt	107	5	study	study	NN
cord-262253-3ovqhypt	107	6	detected	detect	VBD
cord-262253-3ovqhypt	107	7	multiple	multiple	JJ
cord-262253-3ovqhypt	107	8	fungal	fungal	JJ
cord-262253-3ovqhypt	107	9	species	specie	NNS
cord-262253-3ovqhypt	107	10	in	in	IN
cord-262253-3ovqhypt	107	11	AD	ad	NN
cord-262253-3ovqhypt	107	12	brain	brain	NN
cord-262253-3ovqhypt	107	13	samples	sample	NNS
cord-262253-3ovqhypt	107	14	,	,	,
cord-262253-3ovqhypt	107	15	including	include	VBG
cord-262253-3ovqhypt	107	16	Saccharomyces	saccharomyce	NNS
cord-262253-3ovqhypt	107	17	cerevisiae	cerevisiae	NNS
cord-262253-3ovqhypt	107	18	,	,	,
cord-262253-3ovqhypt	107	19	Malassezia	Malassezia	NNP
cord-262253-3ovqhypt	107	20	globosa	globosa	NNP
cord-262253-3ovqhypt	107	21	,	,	,
cord-262253-3ovqhypt	107	22	Malassezia	Malassezia	NNP
cord-262253-3ovqhypt	107	23	restricta	restricta	NN
cord-262253-3ovqhypt	107	24	,	,	,
cord-262253-3ovqhypt	107	25	Penicillium	Penicillium	NNP
cord-262253-3ovqhypt	107	26	and	and	CC
cord-262253-3ovqhypt	107	27	Phoma	Phoma	NNP
cord-262253-3ovqhypt	107	28	[	[	-LRB-
cord-262253-3ovqhypt	107	29	69	69	CD
cord-262253-3ovqhypt	107	30	]	]	-RRB-
cord-262253-3ovqhypt	107	31	.	.	.
cord-262253-3ovqhypt	108	1	Pisa	Pisa	NNP
cord-262253-3ovqhypt	108	2	et	et	NNP
cord-262253-3ovqhypt	108	3	al	al	NNP
cord-262253-3ovqhypt	108	4	.	.	.
cord-262253-3ovqhypt	109	1	have	have	VBP
cord-262253-3ovqhypt	109	2	since	since	IN
cord-262253-3ovqhypt	109	3	followed	follow	VBN
cord-262253-3ovqhypt	109	4	up	up	RP
cord-262253-3ovqhypt	109	5	on	on	IN
cord-262253-3ovqhypt	109	6	this	this	DT
cord-262253-3ovqhypt	109	7	initial	initial	JJ
cord-262253-3ovqhypt	109	8	discovery	discovery	NN
cord-262253-3ovqhypt	109	9	by	by	IN
cord-262253-3ovqhypt	109	10	analyzing	analyze	VBG
cord-262253-3ovqhypt	109	11	the	the	DT
cord-262253-3ovqhypt	109	12	presence	presence	NN
cord-262253-3ovqhypt	109	13	of	of	IN
cord-262253-3ovqhypt	109	14	these	these	DT
cord-262253-3ovqhypt	109	15	species	specie	NNS
cord-262253-3ovqhypt	109	16	between	between	IN
cord-262253-3ovqhypt	109	17	brain	brain	NN
cord-262253-3ovqhypt	109	18	regions	region	NNS
cord-262253-3ovqhypt	109	19	[	[	-LRB-
cord-262253-3ovqhypt	109	20	70	70	CD
cord-262253-3ovqhypt	109	21	]	]	-RRB-
cord-262253-3ovqhypt	109	22	.	.	.
cord-262253-3ovqhypt	110	1	With	with	IN
cord-262253-3ovqhypt	110	2	any	any	DT
cord-262253-3ovqhypt	110	3	of	of	IN
cord-262253-3ovqhypt	110	4	these	these	DT
cord-262253-3ovqhypt	110	5	studies	study	NNS
cord-262253-3ovqhypt	110	6	that	that	WDT
cord-262253-3ovqhypt	110	7	have	have	VBP
cord-262253-3ovqhypt	110	8	been	be	VBN
cord-262253-3ovqhypt	110	9	conducted	conduct	VBN
cord-262253-3ovqhypt	110	10	,	,	,
cord-262253-3ovqhypt	110	11	however	however	RB
cord-262253-3ovqhypt	110	12	,	,	,
cord-262253-3ovqhypt	110	13	it	-PRON-	PRP
cord-262253-3ovqhypt	110	14	is	be	VBZ
cord-262253-3ovqhypt	110	15	important	important	JJ
cord-262253-3ovqhypt	110	16	to	to	TO
cord-262253-3ovqhypt	110	17	recognize	recognize	VB
cord-262253-3ovqhypt	110	18	the	the	DT
cord-262253-3ovqhypt	110	19	technical	technical	JJ
cord-262253-3ovqhypt	110	20	limitations	limitation	NNS
cord-262253-3ovqhypt	110	21	that	that	WDT
cord-262253-3ovqhypt	110	22	arise	arise	VBP
cord-262253-3ovqhypt	110	23	when	when	WRB
cord-262253-3ovqhypt	110	24	studying	study	VBG
cord-262253-3ovqhypt	110	25	microorganisms	microorganism	NNS
cord-262253-3ovqhypt	110	26	and	and	CC
cord-262253-3ovqhypt	110	27	neurodegenerative	neurodegenerative	JJ
cord-262253-3ovqhypt	110	28	disease	disease	NN
cord-262253-3ovqhypt	110	29	.	.	.
cord-262253-3ovqhypt	111	1	Many	many	JJ
cord-262253-3ovqhypt	111	2	of	of	IN
cord-262253-3ovqhypt	111	3	these	these	DT
cord-262253-3ovqhypt	111	4	studies	study	NNS
cord-262253-3ovqhypt	111	5	are	be	VBP
cord-262253-3ovqhypt	111	6	limited	limit	VBN
cord-262253-3ovqhypt	111	7	to	to	IN
cord-262253-3ovqhypt	111	8	the	the	DT
cord-262253-3ovqhypt	111	9	use	use	NN
cord-262253-3ovqhypt	111	10	of	of	IN
cord-262253-3ovqhypt	111	11	post	post	JJ
cord-262253-3ovqhypt	111	12	-	-	JJ
cord-262253-3ovqhypt	111	13	mortem	mortem	JJ
cord-262253-3ovqhypt	111	14	brain	brain	NN
cord-262253-3ovqhypt	111	15	samples	sample	NNS
cord-262253-3ovqhypt	111	16	,	,	,
cord-262253-3ovqhypt	111	17	and	and	CC
cord-262253-3ovqhypt	111	18	thus	thus	RB
cord-262253-3ovqhypt	111	19	present	present	VB
cord-262253-3ovqhypt	111	20	the	the	DT
cord-262253-3ovqhypt	111	21	risk	risk	NN
cord-262253-3ovqhypt	111	22	of	of	IN
cord-262253-3ovqhypt	111	23	contamination	contamination	NN
cord-262253-3ovqhypt	111	24	due	due	IN
cord-262253-3ovqhypt	111	25	to	to	IN
cord-262253-3ovqhypt	111	26	death	death	NN
cord-262253-3ovqhypt	111	27	or	or	CC
cord-262253-3ovqhypt	111	28	the	the	DT
cord-262253-3ovqhypt	111	29	passage	passage	NN
cord-262253-3ovqhypt	111	30	of	of	IN
cord-262253-3ovqhypt	111	31	microbes	microbe	NNS
cord-262253-3ovqhypt	111	32	from	from	IN
cord-262253-3ovqhypt	111	33	other	other	JJ
cord-262253-3ovqhypt	111	34	areas	area	NNS
cord-262253-3ovqhypt	111	35	of	of	IN
cord-262253-3ovqhypt	111	36	the	the	DT
cord-262253-3ovqhypt	111	37	body	body	NN
cord-262253-3ovqhypt	111	38	,	,	,
cord-262253-3ovqhypt	111	39	such	such	JJ
cord-262253-3ovqhypt	111	40	as	as	IN
cord-262253-3ovqhypt	111	41	the	the	DT
cord-262253-3ovqhypt	111	42	gut	gut	NN
cord-262253-3ovqhypt	111	43	to	to	IN
cord-262253-3ovqhypt	111	44	the	the	DT
cord-262253-3ovqhypt	111	45	brain	brain	NN
cord-262253-3ovqhypt	111	46	,	,	,
cord-262253-3ovqhypt	111	47	due	due	IN
cord-262253-3ovqhypt	111	48	to	to	IN
cord-262253-3ovqhypt	111	49	the	the	DT
cord-262253-3ovqhypt	111	50	lack	lack	NN
cord-262253-3ovqhypt	111	51	of	of	IN
cord-262253-3ovqhypt	111	52	a	a	DT
cord-262253-3ovqhypt	111	53	functioning	function	VBG
cord-262253-3ovqhypt	111	54	BBB	BBB	NNP
cord-262253-3ovqhypt	111	55	to	to	TO
cord-262253-3ovqhypt	111	56	prevent	prevent	VB
cord-262253-3ovqhypt	111	57	this	this	DT
cord-262253-3ovqhypt	111	58	leakage	leakage	NN
cord-262253-3ovqhypt	111	59	.	.	.
cord-262253-3ovqhypt	112	1	Depending	depend	VBG
cord-262253-3ovqhypt	112	2	on	on	IN
cord-262253-3ovqhypt	112	3	the	the	DT
cord-262253-3ovqhypt	112	4	organism	organism	NN
cord-262253-3ovqhypt	112	5	,	,	,
cord-262253-3ovqhypt	112	6	there	there	EX
cord-262253-3ovqhypt	112	7	are	be	VBP
cord-262253-3ovqhypt	112	8	several	several	JJ
cord-262253-3ovqhypt	112	9	ways	way	NNS
cord-262253-3ovqhypt	112	10	that	that	WDT
cord-262253-3ovqhypt	112	11	pathogens	pathogen	NNS
cord-262253-3ovqhypt	112	12	can	can	MD
cord-262253-3ovqhypt	112	13	infiltrate	infiltrate	VB
cord-262253-3ovqhypt	112	14	the	the	DT
cord-262253-3ovqhypt	112	15	CNS	CNS	NNP
cord-262253-3ovqhypt	112	16	and	and	CC
cord-262253-3ovqhypt	112	17	potentially	potentially	RB
cord-262253-3ovqhypt	112	18	further	far	RBR
cord-262253-3ovqhypt	112	19	the	the	DT
cord-262253-3ovqhypt	112	20	progression	progression	NN
cord-262253-3ovqhypt	112	21	of	of	IN
cord-262253-3ovqhypt	112	22	AD	ad	NN
cord-262253-3ovqhypt	112	23	.	.	.
cord-262253-3ovqhypt	113	1	The	the	DT
cord-262253-3ovqhypt	113	2	first	first	JJ
cord-262253-3ovqhypt	113	3	is	be	VBZ
cord-262253-3ovqhypt	113	4	through	through	IN
cord-262253-3ovqhypt	113	5	a	a	DT
cord-262253-3ovqhypt	113	6	compromised	compromised	JJ
cord-262253-3ovqhypt	113	7	BBB	bbb	NN
cord-262253-3ovqhypt	113	8	.	.	.
cord-262253-3ovqhypt	114	1	Whereas	whereas	IN
cord-262253-3ovqhypt	114	2	a	a	DT
cord-262253-3ovqhypt	114	3	healthy	healthy	JJ
cord-262253-3ovqhypt	114	4	and	and	CC
cord-262253-3ovqhypt	114	5	functional	functional	JJ
cord-262253-3ovqhypt	114	6	BBB	BBB	NNP
cord-262253-3ovqhypt	114	7	normally	normally	RB
cord-262253-3ovqhypt	114	8	provides	provide	VBZ
cord-262253-3ovqhypt	114	9	a	a	DT
cord-262253-3ovqhypt	114	10	selective	selective	JJ
cord-262253-3ovqhypt	114	11	barrier	barrier	NN
cord-262253-3ovqhypt	114	12	to	to	IN
cord-262253-3ovqhypt	114	13	the	the	DT
cord-262253-3ovqhypt	114	14	passage	passage	NN
cord-262253-3ovqhypt	114	15	of	of	IN
cord-262253-3ovqhypt	114	16	cells	cell	NNS
cord-262253-3ovqhypt	114	17	and	and	CC
cord-262253-3ovqhypt	114	18	molecules	molecule	NNS
cord-262253-3ovqhypt	114	19	into	into	IN
cord-262253-3ovqhypt	114	20	the	the	DT
cord-262253-3ovqhypt	114	21	brain	brain	NN
cord-262253-3ovqhypt	114	22	,	,	,
cord-262253-3ovqhypt	114	23	a	a	DT
cord-262253-3ovqhypt	114	24	compromised	compromise	VBN
cord-262253-3ovqhypt	114	25	BBB	BBB	NNP
cord-262253-3ovqhypt	114	26	can	can	MD
cord-262253-3ovqhypt	114	27	allow	allow	VB
cord-262253-3ovqhypt	114	28	direct	direct	JJ
cord-262253-3ovqhypt	114	29	entry	entry	NN
cord-262253-3ovqhypt	114	30	into	into	IN
cord-262253-3ovqhypt	114	31	the	the	DT
cord-262253-3ovqhypt	114	32	cerebral	cerebral	JJ
cord-262253-3ovqhypt	114	33	spinal	spinal	JJ
cord-262253-3ovqhypt	114	34	fluid	fluid	NN
cord-262253-3ovqhypt	114	35	via	via	IN
cord-262253-3ovqhypt	114	36	the	the	DT
cord-262253-3ovqhypt	114	37	bloodstream	bloodstream	NN
cord-262253-3ovqhypt	114	38	[	[	-LRB-
cord-262253-3ovqhypt	114	39	21	21	CD
cord-262253-3ovqhypt	114	40	]	]	-RRB-
cord-262253-3ovqhypt	114	41	.	.	.
cord-262253-3ovqhypt	115	1	This	this	DT
cord-262253-3ovqhypt	115	2	places	place	VBZ
cord-262253-3ovqhypt	115	3	aging	age	VBG
cord-262253-3ovqhypt	115	4	populations	population	NNS
cord-262253-3ovqhypt	115	5	and	and	CC
cord-262253-3ovqhypt	115	6	those	those	DT
cord-262253-3ovqhypt	115	7	with	with	IN
cord-262253-3ovqhypt	115	8	weakened	weakened	JJ
cord-262253-3ovqhypt	115	9	immune	immune	JJ
cord-262253-3ovqhypt	115	10	responses	response	NNS
cord-262253-3ovqhypt	115	11	especially	especially	RB
cord-262253-3ovqhypt	115	12	at	at	IN
cord-262253-3ovqhypt	115	13	risk	risk	NN
cord-262253-3ovqhypt	115	14	,	,	,
cord-262253-3ovqhypt	115	15	as	as	IN
cord-262253-3ovqhypt	115	16	some	some	DT
cord-262253-3ovqhypt	115	17	viruses	virus	NNS
cord-262253-3ovqhypt	115	18	,	,	,
cord-262253-3ovqhypt	115	19	such	such	JJ
cord-262253-3ovqhypt	115	20	as	as	IN
cord-262253-3ovqhypt	115	21	herpesvirus	herpesvirus	NN
cord-262253-3ovqhypt	115	22	,	,	,
cord-262253-3ovqhypt	115	23	can	can	MD
cord-262253-3ovqhypt	115	24	remain	remain	VB
cord-262253-3ovqhypt	115	25	latent	latent	JJ
cord-262253-3ovqhypt	115	26	after	after	IN
cord-262253-3ovqhypt	115	27	initial	initial	JJ
cord-262253-3ovqhypt	115	28	infection	infection	NN
cord-262253-3ovqhypt	115	29	and	and	CC
cord-262253-3ovqhypt	115	30	then	then	RB
cord-262253-3ovqhypt	115	31	reactivate	reactivate	VB
cord-262253-3ovqhypt	115	32	in	in	IN
cord-262253-3ovqhypt	115	33	aging	age	VBG
cord-262253-3ovqhypt	115	34	individuals	individual	NNS
cord-262253-3ovqhypt	115	35	long	long	RB
cord-262253-3ovqhypt	115	36	after	after	RB
cord-262253-3ovqhypt	115	37	,	,	,
cord-262253-3ovqhypt	115	38	to	to	TO
cord-262253-3ovqhypt	115	39	introduce	introduce	VB
cord-262253-3ovqhypt	115	40	delayed	delay	VBN
cord-262253-3ovqhypt	115	41	adverse	adverse	JJ
cord-262253-3ovqhypt	115	42	complications	complication	NNS
cord-262253-3ovqhypt	115	43	[	[	-LRB-
cord-262253-3ovqhypt	115	44	71	71	CD
cord-262253-3ovqhypt	115	45	]	]	-RRB-
cord-262253-3ovqhypt	115	46	.	.	.
cord-262253-3ovqhypt	116	1	Even	even	RB
cord-262253-3ovqhypt	116	2	with	with	IN
cord-262253-3ovqhypt	116	3	a	a	DT
cord-262253-3ovqhypt	116	4	healthy	healthy	JJ
cord-262253-3ovqhypt	116	5	BBB	bbb	NN
cord-262253-3ovqhypt	116	6	,	,	,
cord-262253-3ovqhypt	116	7	however	however	RB
cord-262253-3ovqhypt	116	8	,	,	,
cord-262253-3ovqhypt	116	9	bacteria	bacteria	NNS
cord-262253-3ovqhypt	116	10	and	and	CC
cord-262253-3ovqhypt	116	11	viruses	virus	NNS
cord-262253-3ovqhypt	116	12	are	be	VBP
cord-262253-3ovqhypt	116	13	still	still	RB
cord-262253-3ovqhypt	116	14	able	able	JJ
cord-262253-3ovqhypt	116	15	to	to	TO
cord-262253-3ovqhypt	116	16	be	be	VB
cord-262253-3ovqhypt	116	17	introduced	introduce	VBN
cord-262253-3ovqhypt	116	18	into	into	IN
cord-262253-3ovqhypt	116	19	the	the	DT
cord-262253-3ovqhypt	116	20	brain	brain	NN
cord-262253-3ovqhypt	116	21	through	through	IN
cord-262253-3ovqhypt	116	22	various	various	JJ
cord-262253-3ovqhypt	116	23	mechanisms	mechanism	NNS
cord-262253-3ovqhypt	116	24	.	.	.
cord-262253-3ovqhypt	117	1	HIV	HIV	NNP
cord-262253-3ovqhypt	117	2	,	,	,
cord-262253-3ovqhypt	117	3	for	for	IN
cord-262253-3ovqhypt	117	4	example	example	NN
cord-262253-3ovqhypt	117	5	,	,	,
cord-262253-3ovqhypt	117	6	is	be	VBZ
cord-262253-3ovqhypt	117	7	carried	carry	VBN
cord-262253-3ovqhypt	117	8	from	from	IN
cord-262253-3ovqhypt	117	9	the	the	DT
cord-262253-3ovqhypt	117	10	immune	immune	JJ
cord-262253-3ovqhypt	117	11	system	system	NN
cord-262253-3ovqhypt	117	12	to	to	IN
cord-262253-3ovqhypt	117	13	the	the	DT
cord-262253-3ovqhypt	117	14	brain	brain	NN
cord-262253-3ovqhypt	117	15	by	by	IN
cord-262253-3ovqhypt	117	16	infected	infected	JJ
cord-262253-3ovqhypt	117	17	leukocytes	leukocyte	NNS
cord-262253-3ovqhypt	117	18	that	that	WDT
cord-262253-3ovqhypt	117	19	are	be	VBP
cord-262253-3ovqhypt	117	20	able	able	JJ
cord-262253-3ovqhypt	117	21	to	to	TO
cord-262253-3ovqhypt	117	22	cross	cross	VB
cord-262253-3ovqhypt	117	23	the	the	DT
cord-262253-3ovqhypt	117	24	BBB	BBB	NNP
cord-262253-3ovqhypt	117	25	.	.	.
cord-262253-3ovqhypt	118	1	P.	P.	NNP
cord-262253-3ovqhypt	118	2	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	118	3	and	and	CC
cord-262253-3ovqhypt	118	4	other	other	JJ
cord-262253-3ovqhypt	118	5	oral	oral	JJ
cord-262253-3ovqhypt	118	6	spirochetes	spirochete	NNS
cord-262253-3ovqhypt	118	7	have	have	VBP
cord-262253-3ovqhypt	118	8	also	also	RB
cord-262253-3ovqhypt	118	9	been	be	VBN
cord-262253-3ovqhypt	118	10	suggested	suggest	VBN
cord-262253-3ovqhypt	118	11	to	to	TO
cord-262253-3ovqhypt	118	12	be	be	VB
cord-262253-3ovqhypt	118	13	capable	capable	JJ
cord-262253-3ovqhypt	118	14	of	of	IN
cord-262253-3ovqhypt	118	15	invading	invade	VBG
cord-262253-3ovqhypt	118	16	the	the	DT
cord-262253-3ovqhypt	118	17	CNS	CNS	NNP
cord-262253-3ovqhypt	118	18	via	via	IN
cord-262253-3ovqhypt	118	19	the	the	DT
cord-262253-3ovqhypt	118	20	oral	oral	JJ
cord-262253-3ovqhypt	118	21	cavity	cavity	NN
cord-262253-3ovqhypt	118	22	,	,	,
cord-262253-3ovqhypt	118	23	through	through	IN
cord-262253-3ovqhypt	118	24	the	the	DT
cord-262253-3ovqhypt	118	25	trigeminal	trigeminal	JJ
cord-262253-3ovqhypt	118	26	nerves	nerve	NNS
cord-262253-3ovqhypt	118	27	and	and	CC
cord-262253-3ovqhypt	118	28	ganglia	ganglion	NNS
cord-262253-3ovqhypt	118	29	[	[	-LRB-
cord-262253-3ovqhypt	118	30	42	42	CD
cord-262253-3ovqhypt	118	31	]	]	-RRB-
cord-262253-3ovqhypt	118	32	.	.	.
cord-262253-3ovqhypt	119	1	Additionally	additionally	RB
cord-262253-3ovqhypt	119	2	,	,	,
cord-262253-3ovqhypt	119	3	pathogens	pathogen	NNS
cord-262253-3ovqhypt	119	4	such	such	JJ
cord-262253-3ovqhypt	119	5	as	as	IN
cord-262253-3ovqhypt	119	6	bacteria	bacteria	NNS
cord-262253-3ovqhypt	119	7	and	and	CC
cord-262253-3ovqhypt	119	8	viruses	virus	NNS
cord-262253-3ovqhypt	119	9	can	can	MD
cord-262253-3ovqhypt	119	10	bypass	bypass	VB
cord-262253-3ovqhypt	119	11	the	the	DT
cord-262253-3ovqhypt	119	12	BBB	BBB	NNP
cord-262253-3ovqhypt	119	13	altogether	altogether	RB
cord-262253-3ovqhypt	119	14	by	by	IN
cord-262253-3ovqhypt	119	15	entering	enter	VBG
cord-262253-3ovqhypt	119	16	through	through	IN
cord-262253-3ovqhypt	119	17	the	the	DT
cord-262253-3ovqhypt	119	18	olfactory	olfactory	JJ
cord-262253-3ovqhypt	119	19	system	system	NN
cord-262253-3ovqhypt	119	20	,	,	,
cord-262253-3ovqhypt	119	21	as	as	IN
cord-262253-3ovqhypt	119	22	the	the	DT
cord-262253-3ovqhypt	119	23	nasal	nasal	NN
cord-262253-3ovqhypt	119	24	cavity	cavity	NN
cord-262253-3ovqhypt	119	25	connects	connect	VBZ
cord-262253-3ovqhypt	119	26	the	the	DT
cord-262253-3ovqhypt	119	27	peripheral	peripheral	JJ
cord-262253-3ovqhypt	119	28	environment	environment	NN
cord-262253-3ovqhypt	119	29	to	to	IN
cord-262253-3ovqhypt	119	30	brain	brain	NN
cord-262253-3ovqhypt	119	31	regions	region	NNS
cord-262253-3ovqhypt	119	32	such	such	JJ
cord-262253-3ovqhypt	119	33	as	as	IN
cord-262253-3ovqhypt	119	34	the	the	DT
cord-262253-3ovqhypt	119	35	olfactory	olfactory	JJ
cord-262253-3ovqhypt	119	36	bulb	bulb	NN
cord-262253-3ovqhypt	119	37	[	[	-LRB-
cord-262253-3ovqhypt	119	38	72	72	CD
cord-262253-3ovqhypt	119	39	]	]	-RRB-
cord-262253-3ovqhypt	119	40	,	,	,
cord-262253-3ovqhypt	119	41	the	the	DT
cord-262253-3ovqhypt	119	42	entorhinal	entorhinal	NNP
cord-262253-3ovqhypt	119	43	cortex	cortex	NNP
cord-262253-3ovqhypt	119	44	and	and	CC
cord-262253-3ovqhypt	119	45	the	the	DT
cord-262253-3ovqhypt	119	46	hippocampus	hippocampus	NN
cord-262253-3ovqhypt	119	47	,	,	,
cord-262253-3ovqhypt	119	48	which	which	WDT
cord-262253-3ovqhypt	119	49	traditionally	traditionally	RB
cord-262253-3ovqhypt	119	50	receive	receive	VBP
cord-262253-3ovqhypt	119	51	smell	smell	NN
cord-262253-3ovqhypt	119	52	sensory	sensory	JJ
cord-262253-3ovqhypt	119	53	signals	signal	NNS
cord-262253-3ovqhypt	119	54	.	.	.
cord-262253-3ovqhypt	120	1	C.	C.	NNP
cord-262253-3ovqhypt	120	2	pneumoniae	pneumoniae	NN
cord-262253-3ovqhypt	120	3	,	,	,
cord-262253-3ovqhypt	120	4	a	a	DT
cord-262253-3ovqhypt	120	5	respiratory	respiratory	JJ
cord-262253-3ovqhypt	120	6	pathogen	pathogen	NN
cord-262253-3ovqhypt	120	7	,	,	,
cord-262253-3ovqhypt	120	8	has	have	VBZ
cord-262253-3ovqhypt	120	9	specifically	specifically	RB
cord-262253-3ovqhypt	120	10	been	be	VBN
cord-262253-3ovqhypt	120	11	suggested	suggest	VBN
cord-262253-3ovqhypt	120	12	to	to	TO
cord-262253-3ovqhypt	120	13	enter	enter	VB
cord-262253-3ovqhypt	120	14	the	the	DT
cord-262253-3ovqhypt	120	15	brain	brain	NN
cord-262253-3ovqhypt	120	16	through	through	IN
cord-262253-3ovqhypt	120	17	the	the	DT
cord-262253-3ovqhypt	120	18	olfactory	olfactory	JJ
cord-262253-3ovqhypt	120	19	system	system	NN
cord-262253-3ovqhypt	120	20	,	,	,
cord-262253-3ovqhypt	120	21	with	with	IN
cord-262253-3ovqhypt	120	22	its	-PRON-	PRP$
cord-262253-3ovqhypt	120	23	presence	presence	NN
cord-262253-3ovqhypt	120	24	detected	detect	VBN
cord-262253-3ovqhypt	120	25	in	in	IN
cord-262253-3ovqhypt	120	26	the	the	DT
cord-262253-3ovqhypt	120	27	entorhinal	entorhinal	NNP
cord-262253-3ovqhypt	120	28	cortex	cortex	NNP
cord-262253-3ovqhypt	120	29	and	and	CC
cord-262253-3ovqhypt	120	30	hippocampal	hippocampal	JJ
cord-262253-3ovqhypt	120	31	formation	formation	NN
cord-262253-3ovqhypt	120	32	of	of	IN
cord-262253-3ovqhypt	120	33	AD	ad	NN
cord-262253-3ovqhypt	120	34	patients	patient	NNS
cord-262253-3ovqhypt	120	35	[	[	-LRB-
cord-262253-3ovqhypt	120	36	73	73	CD
cord-262253-3ovqhypt	120	37	]	]	-RRB-
cord-262253-3ovqhypt	120	38	.	.	.
cord-262253-3ovqhypt	121	1	A	a	DT
cord-262253-3ovqhypt	121	2	recent	recent	JJ
cord-262253-3ovqhypt	121	3	2020	2020	CD
cord-262253-3ovqhypt	121	4	study	study	NN
cord-262253-3ovqhypt	121	5	model	model	NN
cord-262253-3ovqhypt	121	6	demonstrated	demonstrate	VBD
cord-262253-3ovqhypt	121	7	that	that	IN
cord-262253-3ovqhypt	121	8	exposure	exposure	NN
cord-262253-3ovqhypt	121	9	to	to	IN
cord-262253-3ovqhypt	121	10	C.	C.	NNP
cord-262253-3ovqhypt	121	11	pneumoniae	pneumoniae	NN
cord-262253-3ovqhypt	121	12	via	via	IN
cord-262253-3ovqhypt	121	13	the	the	DT
cord-262253-3ovqhypt	121	14	olfactory	olfactory	JJ
cord-262253-3ovqhypt	121	15	system	system	NN
cord-262253-3ovqhypt	121	16	was	be	VBD
cord-262253-3ovqhypt	121	17	sufficient	sufficient	JJ
cord-262253-3ovqhypt	121	18	to	to	TO
cord-262253-3ovqhypt	121	19	induce	induce	VB
cord-262253-3ovqhypt	121	20	Aβ	Aβ	NNP
cord-262253-3ovqhypt	121	21	plaque	plaque	NN
cord-262253-3ovqhypt	121	22	and	and	CC
cord-262253-3ovqhypt	121	23	NFT	NFT	NNP
cord-262253-3ovqhypt	121	24	formation	formation	NN
cord-262253-3ovqhypt	121	25	in	in	IN
cord-262253-3ovqhypt	121	26	the	the	DT
cord-262253-3ovqhypt	121	27	olfactory	olfactory	JJ
cord-262253-3ovqhypt	121	28	cortex	cortex	NN
cord-262253-3ovqhypt	121	29	and	and	CC
cord-262253-3ovqhypt	121	30	hippocampus	hippocampus	NN
cord-262253-3ovqhypt	121	31	of	of	IN
cord-262253-3ovqhypt	121	32	immunocompromised	immunocompromised	JJ
cord-262253-3ovqhypt	121	33	individuals	individual	NNS
cord-262253-3ovqhypt	121	34	[	[	-LRB-
cord-262253-3ovqhypt	121	35	74	74	CD
cord-262253-3ovqhypt	121	36	]	]	-RRB-
cord-262253-3ovqhypt	121	37	.	.	.
cord-262253-3ovqhypt	122	1	This	this	DT
cord-262253-3ovqhypt	122	2	is	be	VBZ
cord-262253-3ovqhypt	122	3	further	further	RB
cord-262253-3ovqhypt	122	4	evidenced	evidence	VBN
cord-262253-3ovqhypt	122	5	by	by	IN
cord-262253-3ovqhypt	122	6	Little	Little	NNP
cord-262253-3ovqhypt	122	7	et	et	NNP
cord-262253-3ovqhypt	122	8	al	al	NNP
cord-262253-3ovqhypt	122	9	.	.	NNP
cord-262253-3ovqhypt	122	10	,	,	,
cord-262253-3ovqhypt	122	11	who	who	WP
cord-262253-3ovqhypt	122	12	found	find	VBD
cord-262253-3ovqhypt	122	13	that	that	IN
cord-262253-3ovqhypt	122	14	intranasal	intranasal	NN
cord-262253-3ovqhypt	122	15	inoculation	inoculation	NN
cord-262253-3ovqhypt	122	16	of	of	IN
cord-262253-3ovqhypt	122	17	C.	C.	NNP
cord-262253-3ovqhypt	122	18	pneumoniae	pneumoniae	NN
cord-262253-3ovqhypt	122	19	was	be	VBD
cord-262253-3ovqhypt	122	20	sufficient	sufficient	JJ
cord-262253-3ovqhypt	122	21	to	to	TO
cord-262253-3ovqhypt	122	22	induce	induce	VB
cord-262253-3ovqhypt	122	23	AD	ad	NN
cord-262253-3ovqhypt	122	24	-	-	HYPH
cord-262253-3ovqhypt	122	25	like	like	JJ
cord-262253-3ovqhypt	122	26	traits	trait	NNS
cord-262253-3ovqhypt	122	27	in	in	IN
cord-262253-3ovqhypt	122	28	mice	mouse	NNS
cord-262253-3ovqhypt	122	29	[	[	-LRB-
cord-262253-3ovqhypt	122	30	75	75	CD
cord-262253-3ovqhypt	122	31	]	]	-RRB-
cord-262253-3ovqhypt	122	32	.	.	.
cord-262253-3ovqhypt	123	1	Once	once	RB
cord-262253-3ovqhypt	123	2	in	in	IN
cord-262253-3ovqhypt	123	3	the	the	DT
cord-262253-3ovqhypt	123	4	brain	brain	NN
cord-262253-3ovqhypt	123	5	,	,	,
cord-262253-3ovqhypt	123	6	there	there	EX
cord-262253-3ovqhypt	123	7	are	be	VBP
cord-262253-3ovqhypt	123	8	several	several	JJ
cord-262253-3ovqhypt	123	9	ways	way	NNS
cord-262253-3ovqhypt	123	10	in	in	IN
cord-262253-3ovqhypt	123	11	which	which	WDT
cord-262253-3ovqhypt	123	12	these	these	DT
cord-262253-3ovqhypt	123	13	pathogens	pathogen	NNS
cord-262253-3ovqhypt	123	14	contribute	contribute	VBP
cord-262253-3ovqhypt	123	15	to	to	IN
cord-262253-3ovqhypt	123	16	the	the	DT
cord-262253-3ovqhypt	123	17	Aβ	Aβ	NNP
cord-262253-3ovqhypt	123	18	production	production	NN
cord-262253-3ovqhypt	123	19	that	that	WDT
cord-262253-3ovqhypt	123	20	is	be	VBZ
cord-262253-3ovqhypt	123	21	characteristic	characteristic	JJ
cord-262253-3ovqhypt	123	22	to	to	IN
cord-262253-3ovqhypt	123	23	AD	ad	NN
cord-262253-3ovqhypt	123	24	.	.	.
cord-262253-3ovqhypt	124	1	One	one	CD
cord-262253-3ovqhypt	124	2	mechanism	mechanism	NN
cord-262253-3ovqhypt	124	3	is	be	VBZ
cord-262253-3ovqhypt	124	4	through	through	IN
cord-262253-3ovqhypt	124	5	the	the	DT
cord-262253-3ovqhypt	124	6	alteration	alteration	NN
cord-262253-3ovqhypt	124	7	of	of	IN
cord-262253-3ovqhypt	124	8	gene	gene	NN
cord-262253-3ovqhypt	124	9	expression	expression	NN
cord-262253-3ovqhypt	124	10	.	.	.
cord-262253-3ovqhypt	125	1	The	the	DT
cord-262253-3ovqhypt	125	2	study	study	NN
cord-262253-3ovqhypt	125	3	previously	previously	RB
cord-262253-3ovqhypt	125	4	mentioned	mention	VBN
cord-262253-3ovqhypt	125	5	by	by	IN
cord-262253-3ovqhypt	125	6	Readhead	Readhead	NNP
cord-262253-3ovqhypt	125	7	et	et	NNP
cord-262253-3ovqhypt	125	8	al	al	NNP
cord-262253-3ovqhypt	125	9	.	.	NNP
cord-262253-3ovqhypt	125	10	found	find	VBD
cord-262253-3ovqhypt	125	11	that	that	IN
cord-262253-3ovqhypt	125	12	HHV-6	HHV-6	NNP
cord-262253-3ovqhypt	125	13	and	and	CC
cord-262253-3ovqhypt	125	14	HHV-7	HHV-7	NNP
cord-262253-3ovqhypt	125	15	interact	interact	VB
cord-262253-3ovqhypt	125	16	with	with	IN
cord-262253-3ovqhypt	125	17	known	know	VBN
cord-262253-3ovqhypt	125	18	regulatory	regulatory	JJ
cord-262253-3ovqhypt	125	19	genes	gene	NNS
cord-262253-3ovqhypt	125	20	responsible	responsible	JJ
cord-262253-3ovqhypt	125	21	for	for	IN
cord-262253-3ovqhypt	125	22	amyloid	amyloid	NN
cord-262253-3ovqhypt	125	23	processing	processing	NN
cord-262253-3ovqhypt	125	24	,	,	,
cord-262253-3ovqhypt	125	25	such	such	JJ
cord-262253-3ovqhypt	125	26	as	as	IN
cord-262253-3ovqhypt	125	27	the	the	DT
cord-262253-3ovqhypt	125	28	amyloid	amyloid	NN
cord-262253-3ovqhypt	125	29	beta	beta	NN
cord-262253-3ovqhypt	125	30	A4	A4	NNP
cord-262253-3ovqhypt	125	31	precursor	precursor	NN
cord-262253-3ovqhypt	125	32	protein	protein	NN
cord-262253-3ovqhypt	125	33	-	-	HYPH
cord-262253-3ovqhypt	125	34	binding	bind	VBG
cord-262253-3ovqhypt	125	35	family	family	NN
cord-262253-3ovqhypt	125	36	(	(	-LRB-
cord-262253-3ovqhypt	125	37	APBB2	APBB2	NNS
cord-262253-3ovqhypt	125	38	)	)	-RRB-
cord-262253-3ovqhypt	125	39	,	,	,
cord-262253-3ovqhypt	125	40	clusterin	clusterin	NNP
cord-262253-3ovqhypt	125	41	(	(	-LRB-
cord-262253-3ovqhypt	125	42	CLU	CLU	NNP
cord-262253-3ovqhypt	125	43	)	)	-RRB-
cord-262253-3ovqhypt	125	44	,	,	,
cord-262253-3ovqhypt	125	45	and	and	CC
cord-262253-3ovqhypt	125	46	gamma	gamma	NN
cord-262253-3ovqhypt	125	47	-	-	HYPH
cord-262253-3ovqhypt	125	48	secretase	secretase	NN
cord-262253-3ovqhypt	125	49	subunit	subunit	NN
cord-262253-3ovqhypt	125	50	presenilin-1	presenilin-1	NNP
cord-262253-3ovqhypt	125	51	(	(	-LRB-
cord-262253-3ovqhypt	125	52	PSEN1	PSEN1	NNP
cord-262253-3ovqhypt	125	53	)	)	-RRB-
cord-262253-3ovqhypt	125	54	[	[	-LRB-
cord-262253-3ovqhypt	125	55	61	61	CD
cord-262253-3ovqhypt	125	56	]	]	-RRB-
cord-262253-3ovqhypt	125	57	.	.	.
cord-262253-3ovqhypt	126	1	Similarly	similarly	RB
cord-262253-3ovqhypt	126	2	,	,	,
cord-262253-3ovqhypt	126	3	infection	infection	NN
cord-262253-3ovqhypt	126	4	of	of	IN
cord-262253-3ovqhypt	126	5	C.	C.	NNP
cord-262253-3ovqhypt	126	6	pneumoniae	pneumoniae	NN
cord-262253-3ovqhypt	126	7	within	within	IN
cord-262253-3ovqhypt	126	8	human	human	JJ
cord-262253-3ovqhypt	126	9	neuronal	neuronal	JJ
cord-262253-3ovqhypt	126	10	cell	cell	NN
cord-262253-3ovqhypt	126	11	cultures	culture	NNS
cord-262253-3ovqhypt	126	12	possibly	possibly	RB
cord-262253-3ovqhypt	126	13	alters	alter	VBZ
cord-262253-3ovqhypt	126	14	calcium	calcium	NN
cord-262253-3ovqhypt	126	15	-	-	HYPH
cord-262253-3ovqhypt	126	16	related	relate	VBN
cord-262253-3ovqhypt	126	17	gene	gene	NN
cord-262253-3ovqhypt	126	18	expression	expression	NN
cord-262253-3ovqhypt	126	19	such	such	JJ
cord-262253-3ovqhypt	126	20	that	that	IN
cord-262253-3ovqhypt	126	21	they	-PRON-	PRP
cord-262253-3ovqhypt	126	22	express	express	VBP
cord-262253-3ovqhypt	126	23	patterns	pattern	NNS
cord-262253-3ovqhypt	126	24	similar	similar	JJ
cord-262253-3ovqhypt	126	25	to	to	IN
cord-262253-3ovqhypt	126	26	those	those	DT
cord-262253-3ovqhypt	126	27	reported	report	VBN
cord-262253-3ovqhypt	126	28	in	in	IN
cord-262253-3ovqhypt	126	29	AD	ad	NN
cord-262253-3ovqhypt	126	30	brain	brain	NN
cord-262253-3ovqhypt	126	31	samples	sample	NNS
cord-262253-3ovqhypt	126	32	[	[	-LRB-
cord-262253-3ovqhypt	126	33	76	76	CD
cord-262253-3ovqhypt	126	34	]	]	-RRB-
cord-262253-3ovqhypt	126	35	.	.	.
cord-262253-3ovqhypt	127	1	Another	another	DT
cord-262253-3ovqhypt	127	2	way	way	NN
cord-262253-3ovqhypt	127	3	viruses	virus	NNS
cord-262253-3ovqhypt	127	4	can	can	MD
cord-262253-3ovqhypt	127	5	influence	influence	VB
cord-262253-3ovqhypt	127	6	Aβ	Aβ	NNP
cord-262253-3ovqhypt	127	7	production	production	NN
cord-262253-3ovqhypt	127	8	is	be	VBZ
cord-262253-3ovqhypt	127	9	through	through	IN
cord-262253-3ovqhypt	127	10	protein	protein	NN
cord-262253-3ovqhypt	127	11	misfolding	misfolding	NN
cord-262253-3ovqhypt	127	12	.	.	.
cord-262253-3ovqhypt	128	1	Specifically	specifically	RB
cord-262253-3ovqhypt	128	2	,	,	,
cord-262253-3ovqhypt	128	3	viruses	virus	NNS
cord-262253-3ovqhypt	128	4	such	such	JJ
cord-262253-3ovqhypt	128	5	as	as	IN
cord-262253-3ovqhypt	128	6	HHV	HHV	NNP
cord-262253-3ovqhypt	128	7	,	,	,
cord-262253-3ovqhypt	128	8	cytomegalovirus	cytomegalovirus	NNP
cord-262253-3ovqhypt	128	9	and	and	CC
cord-262253-3ovqhypt	128	10	Epstein	Epstein	NNP
cord-262253-3ovqhypt	128	11	Barr	Barr	NNP
cord-262253-3ovqhypt	128	12	Virus	Virus	NNP
cord-262253-3ovqhypt	128	13	have	have	VBP
cord-262253-3ovqhypt	128	14	been	be	VBN
cord-262253-3ovqhypt	128	15	shown	show	VBN
cord-262253-3ovqhypt	128	16	to	to	TO
cord-262253-3ovqhypt	128	17	contain	contain	VB
cord-262253-3ovqhypt	128	18	prion	prion	NN
cord-262253-3ovqhypt	128	19	-	-	HYPH
cord-262253-3ovqhypt	128	20	like	like	JJ
cord-262253-3ovqhypt	128	21	domains	domain	NNS
cord-262253-3ovqhypt	128	22	that	that	WDT
cord-262253-3ovqhypt	128	23	may	may	MD
cord-262253-3ovqhypt	128	24	trigger	trigger	VB
cord-262253-3ovqhypt	128	25	the	the	DT
cord-262253-3ovqhypt	128	26	misfolding	misfolding	NN
cord-262253-3ovqhypt	128	27	of	of	IN
cord-262253-3ovqhypt	128	28	proteins	protein	NNS
cord-262253-3ovqhypt	128	29	like	like	IN
cord-262253-3ovqhypt	128	30	Aβ	Aβ	NNP
cord-262253-3ovqhypt	128	31	[	[	-LRB-
cord-262253-3ovqhypt	128	32	77	77	CD
cord-262253-3ovqhypt	128	33	]	]	-RRB-
cord-262253-3ovqhypt	128	34	.	.	.
cord-262253-3ovqhypt	129	1	Through	through	IN
cord-262253-3ovqhypt	129	2	these	these	DT
cord-262253-3ovqhypt	129	3	varying	vary	VBG
cord-262253-3ovqhypt	129	4	mechanisms	mechanism	NNS
cord-262253-3ovqhypt	129	5	,	,	,
cord-262253-3ovqhypt	129	6	many	many	JJ
cord-262253-3ovqhypt	129	7	microorganisms	microorganism	NNS
cord-262253-3ovqhypt	129	8	and	and	CC
cord-262253-3ovqhypt	129	9	viruses	virus	NNS
cord-262253-3ovqhypt	129	10	have	have	VBP
cord-262253-3ovqhypt	129	11	been	be	VBN
cord-262253-3ovqhypt	129	12	found	find	VBN
cord-262253-3ovqhypt	129	13	to	to	TO
cord-262253-3ovqhypt	129	14	initiate	initiate	VB
cord-262253-3ovqhypt	129	15	Aβ	Aβ	NNP
cord-262253-3ovqhypt	129	16	plaque	plaque	NN
cord-262253-3ovqhypt	129	17	formation	formation	NN
cord-262253-3ovqhypt	129	18	.	.	.
cord-262253-3ovqhypt	130	1	In	in	IN
cord-262253-3ovqhypt	130	2	-	-	HYPH
cord-262253-3ovqhypt	130	3	vivo	vivo	NN
cord-262253-3ovqhypt	130	4	studies	study	NNS
cord-262253-3ovqhypt	130	5	have	have	VBP
cord-262253-3ovqhypt	130	6	noted	note	VBN
cord-262253-3ovqhypt	130	7	a	a	DT
cord-262253-3ovqhypt	130	8	correlation	correlation	NN
cord-262253-3ovqhypt	130	9	between	between	IN
cord-262253-3ovqhypt	130	10	viral	viral	JJ
cord-262253-3ovqhypt	130	11	and	and	CC
cord-262253-3ovqhypt	130	12	bacterial	bacterial	JJ
cord-262253-3ovqhypt	130	13	infections	infection	NNS
cord-262253-3ovqhypt	130	14	and	and	CC
cord-262253-3ovqhypt	130	15	the	the	DT
cord-262253-3ovqhypt	130	16	accumulation	accumulation	NN
cord-262253-3ovqhypt	130	17	of	of	IN
cord-262253-3ovqhypt	130	18	Aβ	Aβ	NNP
cord-262253-3ovqhypt	130	19	peptides	peptide	NNS
cord-262253-3ovqhypt	130	20	.	.	.
cord-262253-3ovqhypt	131	1	Mice	mouse	NNS
cord-262253-3ovqhypt	131	2	infected	infect	VBN
cord-262253-3ovqhypt	131	3	with	with	IN
cord-262253-3ovqhypt	131	4	HSV-1	HSV-1	NNS
cord-262253-3ovqhypt	131	5	[	[	-LRB-
cord-262253-3ovqhypt	131	6	78	78	CD
cord-262253-3ovqhypt	131	7	]	]	-RRB-
cord-262253-3ovqhypt	131	8	,	,	,
cord-262253-3ovqhypt	131	9	pseudorabies	pseudorabies	NN
cord-262253-3ovqhypt	131	10	virus	virus	NN
cord-262253-3ovqhypt	131	11	[	[	-LRB-
cord-262253-3ovqhypt	131	12	79	79	CD
cord-262253-3ovqhypt	131	13	]	]	-RRB-
cord-262253-3ovqhypt	131	14	,	,	,
cord-262253-3ovqhypt	131	15	C.	C.	NNP
cord-262253-3ovqhypt	131	16	pneumoniae	pneumoniae	NN
cord-262253-3ovqhypt	131	17	[	[	-LRB-
cord-262253-3ovqhypt	131	18	75	75	CD
cord-262253-3ovqhypt	131	19	]	]	-RRB-
cord-262253-3ovqhypt	131	20	and	and	CC
cord-262253-3ovqhypt	131	21	P.	P.	NNP
cord-262253-3ovqhypt	131	22	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	131	23	[	[	-LRB-
cord-262253-3ovqhypt	132	1	68	68	CD
cord-262253-3ovqhypt	132	2	,	,	,
cord-262253-3ovqhypt	132	3	80	80	CD
cord-262253-3ovqhypt	132	4	]	]	-RRB-
cord-262253-3ovqhypt	132	5	were	be	VBD
cord-262253-3ovqhypt	132	6	found	find	VBN
cord-262253-3ovqhypt	132	7	to	to	TO
cord-262253-3ovqhypt	132	8	have	have	VB
cord-262253-3ovqhypt	132	9	a	a	DT
cord-262253-3ovqhypt	132	10	significantly	significantly	RB
cord-262253-3ovqhypt	132	11	increased	increase	VBN
cord-262253-3ovqhypt	132	12	level	level	NN
cord-262253-3ovqhypt	132	13	of	of	IN
cord-262253-3ovqhypt	132	14	Aβ	Aβ	NNP
cord-262253-3ovqhypt	132	15	1	1	CD
cord-262253-3ovqhypt	132	16	-	-	SYM
cord-262253-3ovqhypt	132	17	42	42	CD
cord-262253-3ovqhypt	132	18	in	in	IN
cord-262253-3ovqhypt	132	19	the	the	DT
cord-262253-3ovqhypt	132	20	brain	brain	NN
cord-262253-3ovqhypt	132	21	.	.	.
cord-262253-3ovqhypt	133	1	In	in	IN
cord-262253-3ovqhypt	133	2	addition	addition	NN
cord-262253-3ovqhypt	133	3	,	,	,
cord-262253-3ovqhypt	133	4	Aβ	Aβ	NNP
cord-262253-3ovqhypt	133	5	expression	expression	NN
cord-262253-3ovqhypt	133	6	was	be	VBD
cord-262253-3ovqhypt	133	7	found	find	VBN
cord-262253-3ovqhypt	133	8	to	to	TO
cord-262253-3ovqhypt	133	9	be	be	VB
cord-262253-3ovqhypt	133	10	upregulated	upregulate	VBN
cord-262253-3ovqhypt	133	11	in	in	IN
cord-262253-3ovqhypt	133	12	rats	rat	NNS
cord-262253-3ovqhypt	133	13	exposed	expose	VBN
cord-262253-3ovqhypt	133	14	to	to	IN
cord-262253-3ovqhypt	133	15	bacterial	bacterial	JJ
cord-262253-3ovqhypt	133	16	pathogens	pathogen	NNS
cord-262253-3ovqhypt	133	17	.	.	.
cord-262253-3ovqhypt	134	1	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	134	2	has	have	VBZ
cord-262253-3ovqhypt	134	3	also	also	RB
cord-262253-3ovqhypt	134	4	been	be	VBN
cord-262253-3ovqhypt	134	5	found	find	VBN
cord-262253-3ovqhypt	134	6	to	to	TO
cord-262253-3ovqhypt	134	7	infect	infect	VB
cord-262253-3ovqhypt	134	8	the	the	DT
cord-262253-3ovqhypt	134	9	hippocampus	hippocampus	NN
cord-262253-3ovqhypt	134	10	region	region	NN
cord-262253-3ovqhypt	134	11	at	at	IN
cord-262253-3ovqhypt	134	12	a	a	DT
cord-262253-3ovqhypt	134	13	greater	great	JJR
cord-262253-3ovqhypt	134	14	rate	rate	NN
cord-262253-3ovqhypt	134	15	;	;	:
cord-262253-3ovqhypt	134	16	the	the	DT
cord-262253-3ovqhypt	134	17	same	same	JJ
cord-262253-3ovqhypt	134	18	area	area	NN
cord-262253-3ovqhypt	134	19	found	find	VBN
cord-262253-3ovqhypt	134	20	to	to	TO
cord-262253-3ovqhypt	134	21	have	have	VB
cord-262253-3ovqhypt	134	22	greater	great	JJR
cord-262253-3ovqhypt	134	23	amounts	amount	NNS
cord-262253-3ovqhypt	134	24	of	of	IN
cord-262253-3ovqhypt	134	25	Aβ	Aβ	NNP
cord-262253-3ovqhypt	134	26	plaques	plaque	NNS
cord-262253-3ovqhypt	134	27	in	in	IN
cord-262253-3ovqhypt	134	28	AD	ad	NN
cord-262253-3ovqhypt	134	29	[	[	-LRB-
cord-262253-3ovqhypt	134	30	81	81	CD
cord-262253-3ovqhypt	134	31	]	]	-RRB-
cord-262253-3ovqhypt	134	32	.	.	.
cord-262253-3ovqhypt	135	1	In	in	IN
cord-262253-3ovqhypt	135	2	vitro	vitro	FW
cord-262253-3ovqhypt	135	3	studies	study	NNS
cord-262253-3ovqhypt	135	4	observed	observe	VBD
cord-262253-3ovqhypt	135	5	cells	cell	NNS
cord-262253-3ovqhypt	135	6	co	co	VBP
cord-262253-3ovqhypt	135	7	-	-	JJ
cord-262253-3ovqhypt	135	8	cultured	cultured	JJ
cord-262253-3ovqhypt	135	9	with	with	IN
cord-262253-3ovqhypt	135	10	either	either	CC
cord-262253-3ovqhypt	135	11	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	135	12	,	,	,
cord-262253-3ovqhypt	135	13	HSV-2	HSV-2	NNP
cord-262253-3ovqhypt	135	14	,	,	,
cord-262253-3ovqhypt	135	15	P.	P.	NNP
cord-262253-3ovqhypt	135	16	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	135	17	or	or	CC
cord-262253-3ovqhypt	135	18	B.	B.	NNP
cord-262253-3ovqhypt	135	19	burgdoferi	burgdoferi	NNP
cord-262253-3ovqhypt	135	20	to	to	TO
cord-262253-3ovqhypt	135	21	have	have	VB
cord-262253-3ovqhypt	135	22	increased	increase	VBN
cord-262253-3ovqhypt	135	23	intracellular	intracellular	JJ
cord-262253-3ovqhypt	135	24	concentrations	concentration	NNS
cord-262253-3ovqhypt	135	25	of	of	IN
cord-262253-3ovqhypt	135	26	Aβ	Aβ	NNP
cord-262253-3ovqhypt	135	27	[	[	-LRB-
cord-262253-3ovqhypt	135	28	80	80	CD
cord-262253-3ovqhypt	135	29	,	,	,
cord-262253-3ovqhypt	135	30	[	[	-LRB-
cord-262253-3ovqhypt	135	31	82	82	CD
cord-262253-3ovqhypt	135	32	]	]	-RRB-
cord-262253-3ovqhypt	135	33	[	[	-LRB-
cord-262253-3ovqhypt	135	34	83	83	CD
cord-262253-3ovqhypt	135	35	]	]	-RRB-
cord-262253-3ovqhypt	135	36	[	[	-LRB-
cord-262253-3ovqhypt	135	37	84	84	CD
cord-262253-3ovqhypt	135	38	]	]	-RRB-
cord-262253-3ovqhypt	135	39	[	[	-LRB-
cord-262253-3ovqhypt	135	40	85	85	CD
cord-262253-3ovqhypt	135	41	]	]	-RRB-
cord-262253-3ovqhypt	135	42	[	[	-LRB-
cord-262253-3ovqhypt	135	43	86	86	CD
cord-262253-3ovqhypt	135	44	]	]	-RRB-
cord-262253-3ovqhypt	135	45	[	[	-LRB-
cord-262253-3ovqhypt	135	46	87	87	CD
cord-262253-3ovqhypt	135	47	]	]	-RRB-
cord-262253-3ovqhypt	135	48	[	[	-LRB-
cord-262253-3ovqhypt	135	49	88	88	CD
cord-262253-3ovqhypt	135	50	]	]	-RRB-
cord-262253-3ovqhypt	135	51	[	[	-LRB-
cord-262253-3ovqhypt	135	52	89	89	CD
cord-262253-3ovqhypt	135	53	]	]	-RRB-
cord-262253-3ovqhypt	135	54	.	.	.
cord-262253-3ovqhypt	136	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	136	2	,	,	,
cord-262253-3ovqhypt	136	3	HSV-1	HSV-1	NNP
cord-262253-3ovqhypt	136	4	has	have	VBZ
cord-262253-3ovqhypt	136	5	been	be	VBN
cord-262253-3ovqhypt	136	6	associated	associate	VBN
cord-262253-3ovqhypt	136	7	with	with	IN
cord-262253-3ovqhypt	136	8	the	the	DT
cord-262253-3ovqhypt	136	9	inhibition	inhibition	NN
cord-262253-3ovqhypt	136	10	of	of	IN
cord-262253-3ovqhypt	136	11	the	the	DT
cord-262253-3ovqhypt	136	12	non	non	JJ
cord-262253-3ovqhypt	136	13	-	-	JJ
cord-262253-3ovqhypt	136	14	amyloidogenic	amyloidogenic	JJ
cord-262253-3ovqhypt	136	15	pathway	pathway	NN
cord-262253-3ovqhypt	136	16	of	of	IN
cord-262253-3ovqhypt	136	17	APP	app	NN
cord-262253-3ovqhypt	136	18	metabolism	metabolism	NN
cord-262253-3ovqhypt	136	19	,	,	,
cord-262253-3ovqhypt	136	20	and	and	CC
cord-262253-3ovqhypt	136	21	the	the	DT
cord-262253-3ovqhypt	136	22	increased	increased	JJ
cord-262253-3ovqhypt	136	23	expression	expression	NN
cord-262253-3ovqhypt	136	24	of	of	IN
cord-262253-3ovqhypt	136	25	β	β	NNP
cord-262253-3ovqhypt	136	26	-	-	HYPH
cord-262253-3ovqhypt	136	27	secretase	secretase	NNP
cord-262253-3ovqhypt	136	28	.	.	.
cord-262253-3ovqhypt	137	1	This	this	DT
cord-262253-3ovqhypt	137	2	is	be	VBZ
cord-262253-3ovqhypt	137	3	evidenced	evidence	VBN
cord-262253-3ovqhypt	137	4	by	by	IN
cord-262253-3ovqhypt	137	5	a	a	DT
cord-262253-3ovqhypt	137	6	2011	2011	CD
cord-262253-3ovqhypt	137	7	study	study	NN
cord-262253-3ovqhypt	137	8	indicating	indicate	VBG
cord-262253-3ovqhypt	137	9	the	the	DT
cord-262253-3ovqhypt	137	10	direct	direct	JJ
cord-262253-3ovqhypt	137	11	and	and	CC
cord-262253-3ovqhypt	137	12	frequent	frequent	JJ
cord-262253-3ovqhypt	137	13	interaction	interaction	NN
cord-262253-3ovqhypt	137	14	between	between	IN
cord-262253-3ovqhypt	137	15	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	137	16	and	and	CC
cord-262253-3ovqhypt	137	17	AβPP	AβPP	NNP
cord-262253-3ovqhypt	137	18	[	[	-LRB-
cord-262253-3ovqhypt	137	19	90	90	CD
cord-262253-3ovqhypt	137	20	]	]	-RRB-
cord-262253-3ovqhypt	137	21	.	.	.
cord-262253-3ovqhypt	138	1	Aβ	aβ	NN
cord-262253-3ovqhypt	138	2	plaques	plaque	NNS
cord-262253-3ovqhypt	138	3	have	have	VBP
cord-262253-3ovqhypt	138	4	also	also	RB
cord-262253-3ovqhypt	138	5	been	be	VBN
cord-262253-3ovqhypt	138	6	identified	identify	VBN
cord-262253-3ovqhypt	138	7	in	in	IN
cord-262253-3ovqhypt	138	8	the	the	DT
cord-262253-3ovqhypt	138	9	brains	brain	NNS
cord-262253-3ovqhypt	138	10	of	of	IN
cord-262253-3ovqhypt	138	11	HIV-1-infected	hiv-1-infecte	VBN
cord-262253-3ovqhypt	138	12	individuals	individual	NNS
cord-262253-3ovqhypt	138	13	.	.	.
cord-262253-3ovqhypt	139	1	Autopsies	autopsy	NNS
cord-262253-3ovqhypt	139	2	performed	perform	VBN
cord-262253-3ovqhypt	139	3	on	on	IN
cord-262253-3ovqhypt	139	4	162	162	CD
cord-262253-3ovqhypt	139	5	HIV	HIV	NNP
cord-262253-3ovqhypt	139	6	positive	positive	JJ
cord-262253-3ovqhypt	139	7	individuals	individual	NNS
cord-262253-3ovqhypt	139	8	found	find	VBD
cord-262253-3ovqhypt	139	9	roughly	roughly	RB
cord-262253-3ovqhypt	139	10	half	half	NN
cord-262253-3ovqhypt	139	11	of	of	IN
cord-262253-3ovqhypt	139	12	them	-PRON-	PRP
cord-262253-3ovqhypt	139	13	to	to	TO
cord-262253-3ovqhypt	139	14	contain	contain	VB
cord-262253-3ovqhypt	139	15	Aβ	Aβ	NNP
cord-262253-3ovqhypt	139	16	plaques	plaque	NNS
cord-262253-3ovqhypt	139	17	[	[	-LRB-
cord-262253-3ovqhypt	139	18	91	91	CD
cord-262253-3ovqhypt	139	19	]	]	-RRB-
cord-262253-3ovqhypt	139	20	.	.	.
cord-262253-3ovqhypt	140	1	Cell	cell	NN
cord-262253-3ovqhypt	140	2	culture	culture	NN
cord-262253-3ovqhypt	140	3	studies	study	NNS
cord-262253-3ovqhypt	140	4	observed	observe	VBD
cord-262253-3ovqhypt	140	5	an	an	DT
cord-262253-3ovqhypt	140	6	increase	increase	NN
cord-262253-3ovqhypt	140	7	in	in	IN
cord-262253-3ovqhypt	140	8	Aβ	Aβ	NNP
cord-262253-3ovqhypt	140	9	production	production	NN
cord-262253-3ovqhypt	140	10	and	and	CC
cord-262253-3ovqhypt	140	11	secretion	secretion	NN
cord-262253-3ovqhypt	140	12	following	follow	VBG
cord-262253-3ovqhypt	140	13	exposure	exposure	NN
cord-262253-3ovqhypt	140	14	to	to	IN
cord-262253-3ovqhypt	140	15	mRNA	mRNA	NNP
cord-262253-3ovqhypt	140	16	and	and	CC
cord-262253-3ovqhypt	140	17	proteins	protein	NNS
cord-262253-3ovqhypt	140	18	from	from	IN
cord-262253-3ovqhypt	140	19	the	the	DT
cord-262253-3ovqhypt	140	20	HIV	HIV	NNP
cord-262253-3ovqhypt	140	21	Nef	Nef	NNP
cord-262253-3ovqhypt	140	22	gene	gene	NN
cord-262253-3ovqhypt	140	23	[	[	-LRB-
cord-262253-3ovqhypt	140	24	92	92	CD
cord-262253-3ovqhypt	140	25	]	]	-RRB-
cord-262253-3ovqhypt	140	26	.	.	.
cord-262253-3ovqhypt	141	1	It	-PRON-	PRP
cord-262253-3ovqhypt	141	2	must	must	MD
cord-262253-3ovqhypt	141	3	be	be	VB
cord-262253-3ovqhypt	141	4	noted	note	VBN
cord-262253-3ovqhypt	141	5	,	,	,
cord-262253-3ovqhypt	141	6	however	however	RB
cord-262253-3ovqhypt	141	7	,	,	,
cord-262253-3ovqhypt	141	8	that	that	IN
cord-262253-3ovqhypt	141	9	the	the	DT
cord-262253-3ovqhypt	141	10	association	association	NN
cord-262253-3ovqhypt	141	11	between	between	IN
cord-262253-3ovqhypt	141	12	infection	infection	NN
cord-262253-3ovqhypt	141	13	and	and	CC
cord-262253-3ovqhypt	141	14	Aβ	Aβ	NNP
cord-262253-3ovqhypt	141	15	plaque	plaque	NN
cord-262253-3ovqhypt	141	16	formation	formation	NN
cord-262253-3ovqhypt	141	17	is	be	VBZ
cord-262253-3ovqhypt	141	18	not	not	RB
cord-262253-3ovqhypt	141	19	consistent	consistent	JJ
cord-262253-3ovqhypt	141	20	across	across	IN
cord-262253-3ovqhypt	141	21	all	all	DT
cord-262253-3ovqhypt	141	22	populations	population	NNS
cord-262253-3ovqhypt	141	23	.	.	.
cord-262253-3ovqhypt	142	1	For	for	IN
cord-262253-3ovqhypt	142	2	example	example	NN
cord-262253-3ovqhypt	142	3	,	,	,
cord-262253-3ovqhypt	142	4	in	in	IN
cord-262253-3ovqhypt	142	5	the	the	DT
cord-262253-3ovqhypt	142	6	study	study	NN
cord-262253-3ovqhypt	142	7	previously	previously	RB
cord-262253-3ovqhypt	142	8	mentioned	mention	VBN
cord-262253-3ovqhypt	142	9	by	by	IN
cord-262253-3ovqhypt	142	10	Sundar	Sundar	NNP
cord-262253-3ovqhypt	142	11	et	et	NNP
cord-262253-3ovqhypt	142	12	al	al	NNP
cord-262253-3ovqhypt	142	13	.	.	.
cord-262253-3ovqhypt	143	1	,	,	,
cord-262253-3ovqhypt	143	2	younger	young	JJR
cord-262253-3ovqhypt	143	3	and	and	CC
cord-262253-3ovqhypt	143	4	healthier	healthy	JJR
cord-262253-3ovqhypt	143	5	individuals	individual	NNS
cord-262253-3ovqhypt	143	6	exposed	expose	VBN
cord-262253-3ovqhypt	143	7	to	to	IN
cord-262253-3ovqhypt	143	8	C.	C.	NNP
cord-262253-3ovqhypt	143	9	pneumoniae	pneumoniae	NNS
cord-262253-3ovqhypt	143	10	did	do	VBD
cord-262253-3ovqhypt	143	11	not	not	RB
cord-262253-3ovqhypt	143	12	exhibit	exhibit	VB
cord-262253-3ovqhypt	143	13	the	the	DT
cord-262253-3ovqhypt	143	14	same	same	JJ
cord-262253-3ovqhypt	143	15	AB	AB	NNP
cord-262253-3ovqhypt	143	16	peptide	peptide	NN
cord-262253-3ovqhypt	143	17	and	and	CC
cord-262253-3ovqhypt	143	18	NFT	NFT	NNP
cord-262253-3ovqhypt	143	19	formation	formation	NN
cord-262253-3ovqhypt	143	20	as	as	IN
cord-262253-3ovqhypt	143	21	older	old	JJR
cord-262253-3ovqhypt	143	22	and	and	CC
cord-262253-3ovqhypt	143	23	immunocompromised	immunocompromised	JJ
cord-262253-3ovqhypt	143	24	subjects	subject	NNS
cord-262253-3ovqhypt	143	25	[	[	-LRB-
cord-262253-3ovqhypt	143	26	74	74	CD
cord-262253-3ovqhypt	143	27	]	]	-RRB-
cord-262253-3ovqhypt	143	28	.	.	.
cord-262253-3ovqhypt	144	1	Moreover	moreover	RB
cord-262253-3ovqhypt	144	2	,	,	,
cord-262253-3ovqhypt	144	3	it	-PRON-	PRP
cord-262253-3ovqhypt	144	4	has	have	VBZ
cord-262253-3ovqhypt	144	5	been	be	VBN
cord-262253-3ovqhypt	144	6	observed	observe	VBN
cord-262253-3ovqhypt	144	7	that	that	IN
cord-262253-3ovqhypt	144	8	genetic	genetic	JJ
cord-262253-3ovqhypt	144	9	discrepancies	discrepancy	NNS
cord-262253-3ovqhypt	144	10	,	,	,
cord-262253-3ovqhypt	144	11	especially	especially	RB
cord-262253-3ovqhypt	144	12	in	in	IN
cord-262253-3ovqhypt	144	13	the	the	DT
cord-262253-3ovqhypt	144	14	APOE	APOE	NNP
cord-262253-3ovqhypt	144	15	gene	gene	NN
cord-262253-3ovqhypt	144	16	,	,	,
cord-262253-3ovqhypt	144	17	influence	influence	VB
cord-262253-3ovqhypt	144	18	one	one	NN
cord-262253-3ovqhypt	144	19	's	's	POS
cord-262253-3ovqhypt	144	20	susceptibility	susceptibility	NN
cord-262253-3ovqhypt	144	21	to	to	IN
cord-262253-3ovqhypt	144	22	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	144	23	infection	infection	NN
cord-262253-3ovqhypt	144	24	and	and	CC
cord-262253-3ovqhypt	144	25	subsequent	subsequent	JJ
cord-262253-3ovqhypt	144	26	AD	ad	NN
cord-262253-3ovqhypt	144	27	development	development	NN
cord-262253-3ovqhypt	144	28	.	.	.
cord-262253-3ovqhypt	145	1	Specifically	specifically	RB
cord-262253-3ovqhypt	145	2	,	,	,
cord-262253-3ovqhypt	145	3	the	the	DT
cord-262253-3ovqhypt	145	4	APOEε4	APOEε4	NNP
cord-262253-3ovqhypt	145	5	allele	allele	NN
cord-262253-3ovqhypt	145	6	places	place	VBZ
cord-262253-3ovqhypt	145	7	individuals	individual	NNS
cord-262253-3ovqhypt	145	8	at	at	IN
cord-262253-3ovqhypt	145	9	a	a	DT
cord-262253-3ovqhypt	145	10	greater	great	JJR
cord-262253-3ovqhypt	145	11	risk	risk	NN
cord-262253-3ovqhypt	145	12	of	of	IN
cord-262253-3ovqhypt	145	13	developing	develop	VBG
cord-262253-3ovqhypt	145	14	HSV-1-associated	hsv-1-associate	VBN
cord-262253-3ovqhypt	145	15	AD	ad	NN
cord-262253-3ovqhypt	145	16	,	,	,
cord-262253-3ovqhypt	145	17	with	with	IN
cord-262253-3ovqhypt	145	18	a	a	DT
cord-262253-3ovqhypt	145	19	combination	combination	NN
cord-262253-3ovqhypt	145	20	of	of	IN
cord-262253-3ovqhypt	145	21	APOEε4	APOEε4	NNP
cord-262253-3ovqhypt	145	22	and	and	CC
cord-262253-3ovqhypt	145	23	HSV-1	HSV-1	NNP
cord-262253-3ovqhypt	145	24	comprising	comprise	VBG
cord-262253-3ovqhypt	145	25	60	60	CD
cord-262253-3ovqhypt	145	26	%	%	NN
cord-262253-3ovqhypt	145	27	of	of	IN
cord-262253-3ovqhypt	145	28	all	all	DT
cord-262253-3ovqhypt	145	29	AD	ad	NN
cord-262253-3ovqhypt	145	30	cases	case	NNS
cord-262253-3ovqhypt	145	31	[	[	-LRB-
cord-262253-3ovqhypt	145	32	93	93	CD
cord-262253-3ovqhypt	145	33	,	,	,
cord-262253-3ovqhypt	145	34	94	94	CD
cord-262253-3ovqhypt	145	35	]	]	-RRB-
cord-262253-3ovqhypt	145	36	.	.	.
cord-262253-3ovqhypt	146	1	This	this	DT
cord-262253-3ovqhypt	146	2	finding	finding	NN
cord-262253-3ovqhypt	146	3	has	have	VBZ
cord-262253-3ovqhypt	146	4	been	be	VBN
cord-262253-3ovqhypt	146	5	recapitulated	recapitulate	VBN
cord-262253-3ovqhypt	146	6	in	in	IN
cord-262253-3ovqhypt	146	7	animal	animal	NN
cord-262253-3ovqhypt	146	8	studies	study	NNS
cord-262253-3ovqhypt	146	9	,	,	,
cord-262253-3ovqhypt	146	10	where	where	WRB
cord-262253-3ovqhypt	146	11	mice	mouse	NNS
cord-262253-3ovqhypt	146	12	with	with	IN
cord-262253-3ovqhypt	146	13	the	the	DT
cord-262253-3ovqhypt	146	14	APOEε4	APOEε4	NNP
cord-262253-3ovqhypt	146	15	allele	allele	NN
cord-262253-3ovqhypt	146	16	display	display	NN
cord-262253-3ovqhypt	146	17	a	a	DT
cord-262253-3ovqhypt	146	18	greater	great	JJR
cord-262253-3ovqhypt	146	19	viral	viral	JJ
cord-262253-3ovqhypt	146	20	load	load	NN
cord-262253-3ovqhypt	146	21	than	than	IN
cord-262253-3ovqhypt	146	22	mice	mouse	NNS
cord-262253-3ovqhypt	146	23	with	with	IN
cord-262253-3ovqhypt	146	24	other	other	JJ
cord-262253-3ovqhypt	146	25	allele	allele	NN
cord-262253-3ovqhypt	146	26	types	type	NNS
cord-262253-3ovqhypt	146	27	after	after	IN
cord-262253-3ovqhypt	146	28	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	146	29	infection	infection	NN
cord-262253-3ovqhypt	146	30	[	[	-LRB-
cord-262253-3ovqhypt	146	31	95	95	CD
cord-262253-3ovqhypt	146	32	]	]	-RRB-
cord-262253-3ovqhypt	146	33	.	.	.
cord-262253-3ovqhypt	147	1	It	-PRON-	PRP
cord-262253-3ovqhypt	147	2	is	be	VBZ
cord-262253-3ovqhypt	147	3	clear	clear	JJ
cord-262253-3ovqhypt	147	4	that	that	IN
cord-262253-3ovqhypt	147	5	a	a	DT
cord-262253-3ovqhypt	147	6	relation	relation	NN
cord-262253-3ovqhypt	147	7	exists	exist	VBZ
cord-262253-3ovqhypt	147	8	between	between	IN
cord-262253-3ovqhypt	147	9	bacterial	bacterial	JJ
cord-262253-3ovqhypt	147	10	and	and	CC
cord-262253-3ovqhypt	147	11	viral	viral	JJ
cord-262253-3ovqhypt	147	12	infections	infection	NNS
cord-262253-3ovqhypt	147	13	and	and	CC
cord-262253-3ovqhypt	147	14	Aβ	Aβ	NNP
cord-262253-3ovqhypt	147	15	production	production	NN
cord-262253-3ovqhypt	147	16	rate	rate	NN
cord-262253-3ovqhypt	147	17	,	,	,
cord-262253-3ovqhypt	147	18	as	as	IN
cord-262253-3ovqhypt	147	19	described	describe	VBN
cord-262253-3ovqhypt	147	20	in	in	IN
cord-262253-3ovqhypt	147	21	the	the	DT
cord-262253-3ovqhypt	147	22	previous	previous	JJ
cord-262253-3ovqhypt	147	23	section	section	NN
cord-262253-3ovqhypt	147	24	.	.	.
cord-262253-3ovqhypt	148	1	Aβ	aβ	NN
cord-262253-3ovqhypt	148	2	peptides	peptide	NNS
cord-262253-3ovqhypt	148	3	have	have	VBP
cord-262253-3ovqhypt	148	4	long	long	RB
cord-262253-3ovqhypt	148	5	been	be	VBN
cord-262253-3ovqhypt	148	6	thought	think	VBN
cord-262253-3ovqhypt	148	7	to	to	TO
cord-262253-3ovqhypt	148	8	lack	lack	VB
cord-262253-3ovqhypt	148	9	any	any	DT
cord-262253-3ovqhypt	148	10	physiological	physiological	JJ
cord-262253-3ovqhypt	148	11	function	function	NN
cord-262253-3ovqhypt	148	12	;	;	:
cord-262253-3ovqhypt	148	13	however	however	RB
cord-262253-3ovqhypt	148	14	,	,	,
cord-262253-3ovqhypt	148	15	this	this	DT
cord-262253-3ovqhypt	148	16	notion	notion	NN
cord-262253-3ovqhypt	148	17	has	have	VBZ
cord-262253-3ovqhypt	148	18	been	be	VBN
cord-262253-3ovqhypt	148	19	challenged	challenge	VBN
cord-262253-3ovqhypt	148	20	in	in	IN
cord-262253-3ovqhypt	148	21	recent	recent	JJ
cord-262253-3ovqhypt	148	22	years	year	NNS
cord-262253-3ovqhypt	148	23	.	.	.
cord-262253-3ovqhypt	149	1	Clinical	clinical	JJ
cord-262253-3ovqhypt	149	2	studies	study	NNS
cord-262253-3ovqhypt	149	3	have	have	VBP
cord-262253-3ovqhypt	149	4	observed	observe	VBN
cord-262253-3ovqhypt	149	5	the	the	DT
cord-262253-3ovqhypt	149	6	depletion	depletion	NN
cord-262253-3ovqhypt	149	7	of	of	IN
cord-262253-3ovqhypt	149	8	Aβ	Aβ	NNP
cord-262253-3ovqhypt	149	9	peptides	peptide	NNS
cord-262253-3ovqhypt	149	10	,	,	,
cord-262253-3ovqhypt	149	11	through	through	IN
cord-262253-3ovqhypt	149	12	anti	anti	JJ
cord-262253-3ovqhypt	149	13	-	-	JJ
cord-262253-3ovqhypt	149	14	Aβ	aβ	JJ
cord-262253-3ovqhypt	149	15	therapies	therapy	NNS
cord-262253-3ovqhypt	149	16	,	,	,
cord-262253-3ovqhypt	149	17	to	to	TO
cord-262253-3ovqhypt	149	18	increase	increase	VB
cord-262253-3ovqhypt	149	19	the	the	DT
cord-262253-3ovqhypt	149	20	rate	rate	NN
cord-262253-3ovqhypt	149	21	of	of	IN
cord-262253-3ovqhypt	149	22	infections	infection	NNS
cord-262253-3ovqhypt	149	23	in	in	IN
cord-262253-3ovqhypt	149	24	some	some	DT
cord-262253-3ovqhypt	149	25	participants	participant	NNS
cord-262253-3ovqhypt	149	26	.	.	.
cord-262253-3ovqhypt	150	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	150	2	,	,	,
cord-262253-3ovqhypt	150	3	Aβ	Aβ	NNP
cord-262253-3ovqhypt	150	4	plaques	plaque	NNS
cord-262253-3ovqhypt	150	5	have	have	VBP
cord-262253-3ovqhypt	150	6	been	be	VBN
cord-262253-3ovqhypt	150	7	found	find	VBN
cord-262253-3ovqhypt	150	8	to	to	TO
cord-262253-3ovqhypt	150	9	contain	contain	VB
cord-262253-3ovqhypt	150	10	microbial	microbial	JJ
cord-262253-3ovqhypt	150	11	and	and	CC
cord-262253-3ovqhypt	150	12	viral	viral	JJ
cord-262253-3ovqhypt	150	13	DNA	dna	NN
cord-262253-3ovqhypt	150	14	,	,	,
cord-262253-3ovqhypt	150	15	such	such	JJ
cord-262253-3ovqhypt	150	16	as	as	IN
cord-262253-3ovqhypt	150	17	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	150	18	.	.	.
cord-262253-3ovqhypt	151	1	One	one	CD
cord-262253-3ovqhypt	151	2	study	study	NN
cord-262253-3ovqhypt	151	3	identified	identify	VBD
cord-262253-3ovqhypt	151	4	HSV-1	HSV-1	NNP
cord-262253-3ovqhypt	151	5	virus	virus	NN
cord-262253-3ovqhypt	151	6	DNA	dna	NN
cord-262253-3ovqhypt	151	7	in	in	IN
cord-262253-3ovqhypt	151	8	roughly	roughly	RB
cord-262253-3ovqhypt	151	9	90	90	CD
cord-262253-3ovqhypt	151	10	%	%	NN
cord-262253-3ovqhypt	151	11	of	of	IN
cord-262253-3ovqhypt	151	12	Aβ	Aβ	NNP
cord-262253-3ovqhypt	151	13	plaques	plaque	NNS
cord-262253-3ovqhypt	151	14	[	[	-LRB-
cord-262253-3ovqhypt	151	15	96	96	CD
cord-262253-3ovqhypt	151	16	]	]	-RRB-
cord-262253-3ovqhypt	151	17	.	.	.
cord-262253-3ovqhypt	152	1	In	in	IN
cord-262253-3ovqhypt	152	2	addition	addition	NN
cord-262253-3ovqhypt	152	3	,	,	,
cord-262253-3ovqhypt	152	4	AD	ad	NN
cord-262253-3ovqhypt	152	5	brains	brain	NNS
cord-262253-3ovqhypt	152	6	have	have	VBP
cord-262253-3ovqhypt	152	7	been	be	VBN
cord-262253-3ovqhypt	152	8	associated	associate	VBN
cord-262253-3ovqhypt	152	9	with	with	IN
cord-262253-3ovqhypt	152	10	5-to	5-to	CD
cord-262253-3ovqhypt	152	11	10-fold	10-fold	JJ
cord-262253-3ovqhypt	152	12	increases	increase	NNS
cord-262253-3ovqhypt	152	13	in	in	IN
cord-262253-3ovqhypt	152	14	bacterial	bacterial	JJ
cord-262253-3ovqhypt	152	15	read	read	NN
cord-262253-3ovqhypt	152	16	compared	compare	VBN
cord-262253-3ovqhypt	152	17	to	to	IN
cord-262253-3ovqhypt	152	18	control	control	NN
cord-262253-3ovqhypt	152	19	brains	brain	NNS
cord-262253-3ovqhypt	152	20	[	[	-LRB-
cord-262253-3ovqhypt	152	21	64	64	CD
cord-262253-3ovqhypt	152	22	]	]	-RRB-
cord-262253-3ovqhypt	152	23	.	.	.
cord-262253-3ovqhypt	153	1	In	in	IN
cord-262253-3ovqhypt	153	2	the	the	DT
cord-262253-3ovqhypt	153	3	presence	presence	NN
cord-262253-3ovqhypt	153	4	of	of	IN
cord-262253-3ovqhypt	153	5	bacterial	bacterial	JJ
cord-262253-3ovqhypt	153	6	lipopolysaccharides	lipopolysaccharides	NNP
cord-262253-3ovqhypt	153	7	,	,	,
cord-262253-3ovqhypt	153	8	microglial	microglial	JJ
cord-262253-3ovqhypt	153	9	cells	cell	NNS
cord-262253-3ovqhypt	153	10	have	have	VBP
cord-262253-3ovqhypt	153	11	also	also	RB
cord-262253-3ovqhypt	153	12	been	be	VBN
cord-262253-3ovqhypt	153	13	shown	show	VBN
cord-262253-3ovqhypt	153	14	to	to	TO
cord-262253-3ovqhypt	153	15	upregulate	upregulate	VB
cord-262253-3ovqhypt	153	16	Aβ	Aβ	NNP
cord-262253-3ovqhypt	153	17	production	production	NN
cord-262253-3ovqhypt	153	18	[	[	-LRB-
cord-262253-3ovqhypt	153	19	97	97	CD
cord-262253-3ovqhypt	153	20	]	]	-RRB-
cord-262253-3ovqhypt	153	21	.	.	.
cord-262253-3ovqhypt	154	1	From	from	IN
cord-262253-3ovqhypt	154	2	these	these	DT
cord-262253-3ovqhypt	154	3	and	and	CC
cord-262253-3ovqhypt	154	4	similar	similar	JJ
cord-262253-3ovqhypt	154	5	findings	finding	NNS
cord-262253-3ovqhypt	154	6	,	,	,
cord-262253-3ovqhypt	154	7	it	-PRON-	PRP
cord-262253-3ovqhypt	154	8	has	have	VBZ
cord-262253-3ovqhypt	154	9	been	be	VBN
cord-262253-3ovqhypt	154	10	suggested	suggest	VBN
cord-262253-3ovqhypt	154	11	that	that	IN
cord-262253-3ovqhypt	154	12	the	the	DT
cord-262253-3ovqhypt	154	13	pathogenesis	pathogenesis	NN
cord-262253-3ovqhypt	154	14	of	of	IN
cord-262253-3ovqhypt	154	15	AD	ad	NN
cord-262253-3ovqhypt	154	16	could	could	MD
cord-262253-3ovqhypt	154	17	be	be	VB
cord-262253-3ovqhypt	154	18	triggered	trigger	VBN
cord-262253-3ovqhypt	154	19	by	by	IN
cord-262253-3ovqhypt	154	20	viral	viral	JJ
cord-262253-3ovqhypt	154	21	and/or	and/or	CC
cord-262253-3ovqhypt	154	22	microbial	microbial	JJ
cord-262253-3ovqhypt	154	23	infections	infection	NNS
cord-262253-3ovqhypt	154	24	.	.	.
cord-262253-3ovqhypt	155	1	These	these	DT
cord-262253-3ovqhypt	155	2	observations	observation	NNS
cord-262253-3ovqhypt	155	3	led	lead	VBD
cord-262253-3ovqhypt	155	4	to	to	IN
cord-262253-3ovqhypt	155	5	the	the	DT
cord-262253-3ovqhypt	155	6	recent	recent	JJ
cord-262253-3ovqhypt	155	7	development	development	NN
cord-262253-3ovqhypt	155	8	of	of	IN
cord-262253-3ovqhypt	155	9	the	the	DT
cord-262253-3ovqhypt	155	10	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	155	11	protection	protection	NN
cord-262253-3ovqhypt	155	12	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	155	13	for	for	IN
cord-262253-3ovqhypt	155	14	AD	ad	NN
cord-262253-3ovqhypt	155	15	,	,	,
cord-262253-3ovqhypt	155	16	which	which	WDT
cord-262253-3ovqhypt	155	17	explores	explore	VBZ
cord-262253-3ovqhypt	155	18	the	the	DT
cord-262253-3ovqhypt	155	19	notion	notion	NN
cord-262253-3ovqhypt	155	20	of	of	IN
cord-262253-3ovqhypt	155	21	Aβ	Aβ	NNP
cord-262253-3ovqhypt	155	22	peptides	peptide	NNS
cord-262253-3ovqhypt	155	23	having	have	VBG
cord-262253-3ovqhypt	155	24	a	a	DT
cord-262253-3ovqhypt	155	25	role	role	NN
cord-262253-3ovqhypt	155	26	in	in	IN
cord-262253-3ovqhypt	155	27	innate	innate	JJ
cord-262253-3ovqhypt	155	28	immunity	immunity	NN
cord-262253-3ovqhypt	155	29	as	as	IN
cord-262253-3ovqhypt	155	30	an	an	DT
cord-262253-3ovqhypt	155	31	AMP	AMP	NNP
cord-262253-3ovqhypt	155	32	that	that	IN
cord-262253-3ovqhypt	155	33	aids	aid	VBZ
cord-262253-3ovqhypt	155	34	in	in	IN
cord-262253-3ovqhypt	155	35	the	the	DT
cord-262253-3ovqhypt	155	36	entrapment	entrapment	NN
cord-262253-3ovqhypt	155	37	and	and	CC
cord-262253-3ovqhypt	155	38	degradation	degradation	NN
cord-262253-3ovqhypt	155	39	of	of	IN
cord-262253-3ovqhypt	155	40	invading	invade	VBG
cord-262253-3ovqhypt	155	41	bacteria	bacteria	NNS
cord-262253-3ovqhypt	155	42	and	and	CC
cord-262253-3ovqhypt	155	43	viruses	virus	NNS
cord-262253-3ovqhypt	155	44	.	.	.
cord-262253-3ovqhypt	156	1	The	the	DT
cord-262253-3ovqhypt	156	2	innate	innate	JJ
cord-262253-3ovqhypt	156	3	immune	immune	JJ
cord-262253-3ovqhypt	156	4	system	system	NN
cord-262253-3ovqhypt	156	5	utilizes	utilize	VBZ
cord-262253-3ovqhypt	156	6	AMPs	amp	NNS
cord-262253-3ovqhypt	156	7	to	to	TO
cord-262253-3ovqhypt	156	8	target	target	VB
cord-262253-3ovqhypt	156	9	invading	invade	VBG
cord-262253-3ovqhypt	156	10	microorganisms	microorganism	NNS
cord-262253-3ovqhypt	156	11	,	,	,
cord-262253-3ovqhypt	156	12	such	such	JJ
cord-262253-3ovqhypt	156	13	as	as	IN
cord-262253-3ovqhypt	156	14	bacteria	bacteria	NNS
cord-262253-3ovqhypt	156	15	,	,	,
cord-262253-3ovqhypt	156	16	viruses	virus	NNS
cord-262253-3ovqhypt	156	17	,	,	,
cord-262253-3ovqhypt	156	18	fungi	fungus	NNS
cord-262253-3ovqhypt	156	19	,	,	,
cord-262253-3ovqhypt	156	20	and	and	CC
cord-262253-3ovqhypt	156	21	in	in	IN
cord-262253-3ovqhypt	156	22	some	some	DT
cord-262253-3ovqhypt	156	23	instances	instance	NNS
cord-262253-3ovqhypt	156	24	cancerous	cancerous	JJ
cord-262253-3ovqhypt	156	25	cells	cell	NNS
cord-262253-3ovqhypt	156	26	.	.	.
cord-262253-3ovqhypt	157	1	Mammalian	mammalian	JJ
cord-262253-3ovqhypt	157	2	AMPs	amp	NNS
cord-262253-3ovqhypt	157	3	exist	exist	VBP
cord-262253-3ovqhypt	157	4	in	in	IN
cord-262253-3ovqhypt	157	5	three	three	CD
cord-262253-3ovqhypt	157	6	main	main	JJ
cord-262253-3ovqhypt	157	7	families	family	NNS
cord-262253-3ovqhypt	157	8	:	:	:
cord-262253-3ovqhypt	157	9	defensins	defensins	NNP
cord-262253-3ovqhypt	157	10	,	,	,
cord-262253-3ovqhypt	157	11	histatins	histatins	NNP
cord-262253-3ovqhypt	157	12	and	and	CC
cord-262253-3ovqhypt	157	13	cathelicidins	cathelicidins	NNP
cord-262253-3ovqhypt	157	14	[	[	-LRB-
cord-262253-3ovqhypt	157	15	98	98	CD
cord-262253-3ovqhypt	157	16	]	]	-RRB-
cord-262253-3ovqhypt	157	17	.	.	.
cord-262253-3ovqhypt	158	1	Similar	similar	JJ
cord-262253-3ovqhypt	158	2	to	to	IN
cord-262253-3ovqhypt	158	3	how	how	WRB
cord-262253-3ovqhypt	158	4	Aβ	Aβ	NNP
cord-262253-3ovqhypt	158	5	peptides	peptide	NNS
cord-262253-3ovqhypt	158	6	are	be	VBP
cord-262253-3ovqhypt	158	7	generated	generate	VBN
cord-262253-3ovqhypt	158	8	through	through	IN
cord-262253-3ovqhypt	158	9	the	the	DT
cord-262253-3ovqhypt	158	10	two	two	CD
cord-262253-3ovqhypt	158	11	-	-	HYPH
cord-262253-3ovqhypt	158	12	step	step	NN
cord-262253-3ovqhypt	158	13	cleavage	cleavage	NN
cord-262253-3ovqhypt	158	14	of	of	IN
cord-262253-3ovqhypt	158	15	APP	app	NN
cord-262253-3ovqhypt	158	16	,	,	,
cord-262253-3ovqhypt	158	17	AMPs	amp	NNS
cord-262253-3ovqhypt	158	18	are	be	VBP
cord-262253-3ovqhypt	158	19	also	also	RB
cord-262253-3ovqhypt	158	20	formed	form	VBN
cord-262253-3ovqhypt	158	21	from	from	IN
cord-262253-3ovqhypt	158	22	the	the	DT
cord-262253-3ovqhypt	158	23	breakdown	breakdown	NN
cord-262253-3ovqhypt	158	24	of	of	IN
cord-262253-3ovqhypt	158	25	larger	large	JJR
cord-262253-3ovqhypt	158	26	precursor	precursor	NN
cord-262253-3ovqhypt	158	27	proteins	protein	NNS
cord-262253-3ovqhypt	158	28	.	.	.
cord-262253-3ovqhypt	159	1	Examples	example	NNS
cord-262253-3ovqhypt	159	2	of	of	IN
cord-262253-3ovqhypt	159	3	amyloid	amyloid	NN
cord-262253-3ovqhypt	159	4	AMPs	amp	NNS
cord-262253-3ovqhypt	159	5	that	that	WDT
cord-262253-3ovqhypt	159	6	have	have	VBP
cord-262253-3ovqhypt	159	7	a	a	DT
cord-262253-3ovqhypt	159	8	role	role	NN
cord-262253-3ovqhypt	159	9	in	in	IN
cord-262253-3ovqhypt	159	10	immunity	immunity	NN
cord-262253-3ovqhypt	159	11	are	be	VBP
cord-262253-3ovqhypt	159	12	present	present	JJ
cord-262253-3ovqhypt	159	13	in	in	IN
cord-262253-3ovqhypt	159	14	the	the	DT
cord-262253-3ovqhypt	159	15	human	human	JJ
cord-262253-3ovqhypt	159	16	body	body	NN
cord-262253-3ovqhypt	159	17	.	.	.
cord-262253-3ovqhypt	160	1	Amyloidogenic	Amyloidogenic	NNP
cord-262253-3ovqhypt	160	2	major	major	JJ
cord-262253-3ovqhypt	160	3	basic	basic	JJ
cord-262253-3ovqhypt	160	4	protein-1	protein-1	NNP
cord-262253-3ovqhypt	160	5	(	(	-LRB-
cord-262253-3ovqhypt	160	6	MBP-1	MBP-1	NNP
cord-262253-3ovqhypt	160	7	)	)	-RRB-
cord-262253-3ovqhypt	160	8	is	be	VBZ
cord-262253-3ovqhypt	160	9	implemented	implement	VBN
cord-262253-3ovqhypt	160	10	in	in	IN
cord-262253-3ovqhypt	160	11	eosinophils	eosinophils	NN
cord-262253-3ovqhypt	160	12	against	against	IN
cord-262253-3ovqhypt	160	13	pathogens	pathogen	NNS
cord-262253-3ovqhypt	160	14	[	[	-LRB-
cord-262253-3ovqhypt	160	15	99	99	CD
cord-262253-3ovqhypt	160	16	]	]	-RRB-
cord-262253-3ovqhypt	160	17	.	.	.
cord-262253-3ovqhypt	161	1	Like	like	IN
cord-262253-3ovqhypt	161	2	Aβ	Aβ	NNP
cord-262253-3ovqhypt	161	3	peptides	peptide	NNS
cord-262253-3ovqhypt	161	4	,	,	,
cord-262253-3ovqhypt	161	5	MBP-1	MBP-1	NNP
cord-262253-3ovqhypt	161	6	also	also	RB
cord-262253-3ovqhypt	161	7	forms	form	VBZ
cord-262253-3ovqhypt	161	8	aggregates	aggregate	NNS
cord-262253-3ovqhypt	161	9	,	,	,
cord-262253-3ovqhypt	161	10	specifically	specifically	RB
cord-262253-3ovqhypt	161	11	at	at	IN
cord-262253-3ovqhypt	161	12	the	the	DT
cord-262253-3ovqhypt	161	13	surface	surface	NN
cord-262253-3ovqhypt	161	14	of	of	IN
cord-262253-3ovqhypt	161	15	the	the	DT
cord-262253-3ovqhypt	161	16	bacteria	bacteria	NNS
cord-262253-3ovqhypt	161	17	to	to	TO
cord-262253-3ovqhypt	161	18	limit	limit	VB
cord-262253-3ovqhypt	161	19	its	-PRON-	PRP$
cord-262253-3ovqhypt	161	20	spread	spread	NN
cord-262253-3ovqhypt	161	21	.	.	.
cord-262253-3ovqhypt	162	1	Further	further	JJ
cord-262253-3ovqhypt	162	2	support	support	NN
cord-262253-3ovqhypt	162	3	of	of	IN
cord-262253-3ovqhypt	162	4	Aβ	Aβ	NNP
cord-262253-3ovqhypt	162	5	peptides	peptide	NNS
cord-262253-3ovqhypt	162	6	being	be	VBG
cord-262253-3ovqhypt	162	7	AMP	amp	NN
cord-262253-3ovqhypt	162	8	stems	stem	NNS
cord-262253-3ovqhypt	162	9	from	from	IN
cord-262253-3ovqhypt	162	10	their	-PRON-	PRP$
cord-262253-3ovqhypt	162	11	similarity	similarity	NN
cord-262253-3ovqhypt	162	12	to	to	IN
cord-262253-3ovqhypt	162	13	AMP	AMP	NNP
cord-262253-3ovqhypt	162	14	LL-37	LL-37	NNP
cord-262253-3ovqhypt	162	15	,	,	,
cord-262253-3ovqhypt	162	16	the	the	DT
cord-262253-3ovqhypt	162	17	only	only	JJ
cord-262253-3ovqhypt	162	18	cathelicidin	cathelicidin	NNP
cord-262253-3ovqhypt	162	19	identified	identify	VBN
cord-262253-3ovqhypt	162	20	thus	thus	RB
cord-262253-3ovqhypt	162	21	far	far	RB
cord-262253-3ovqhypt	162	22	in	in	IN
cord-262253-3ovqhypt	162	23	humans	human	NNS
cord-262253-3ovqhypt	162	24	.	.	.
cord-262253-3ovqhypt	163	1	Both	both	DT
cord-262253-3ovqhypt	163	2	compounds	compound	NNS
cord-262253-3ovqhypt	163	3	exhibit	exhibit	VBP
cord-262253-3ovqhypt	163	4	tendencies	tendency	NNS
cord-262253-3ovqhypt	163	5	to	to	TO
cord-262253-3ovqhypt	163	6	form	form	VB
cord-262253-3ovqhypt	163	7	cytotoxic	cytotoxic	JJ
cord-262253-3ovqhypt	163	8	soluble	soluble	JJ
cord-262253-3ovqhypt	163	9	oligomers	oligomer	NNS
cord-262253-3ovqhypt	163	10	and	and	CC
cord-262253-3ovqhypt	163	11	insoluble	insoluble	JJ
cord-262253-3ovqhypt	163	12	fibrils	fibril	NNS
cord-262253-3ovqhypt	163	13	,	,	,
cord-262253-3ovqhypt	163	14	characteristic	characteristic	JJ
cord-262253-3ovqhypt	163	15	features	feature	NNS
cord-262253-3ovqhypt	163	16	of	of	IN
cord-262253-3ovqhypt	163	17	tinctorial	tinctorial	JJ
cord-262253-3ovqhypt	163	18	amyloid	amyloid	NN
cord-262253-3ovqhypt	163	19	[	[	-LRB-
cord-262253-3ovqhypt	163	20	98	98	CD
cord-262253-3ovqhypt	163	21	]	]	-RRB-
cord-262253-3ovqhypt	163	22	.	.	.
cord-262253-3ovqhypt	164	1	Additionally	additionally	RB
cord-262253-3ovqhypt	164	2	,	,	,
cord-262253-3ovqhypt	164	3	deficiency	deficiency	NN
cord-262253-3ovqhypt	164	4	in	in	IN
cord-262253-3ovqhypt	164	5	the	the	DT
cord-262253-3ovqhypt	164	6	latter	latter	NN
cord-262253-3ovqhypt	164	7	can	can	MD
cord-262253-3ovqhypt	164	8	result	result	VB
cord-262253-3ovqhypt	164	9	in	in	IN
cord-262253-3ovqhypt	164	10	Kostmann	Kostmann	NNP
cord-262253-3ovqhypt	164	11	syndrome	syndrome	NN
cord-262253-3ovqhypt	164	12	,	,	,
cord-262253-3ovqhypt	164	13	an	an	DT
cord-262253-3ovqhypt	164	14	immunodeficiency	immunodeficiency	NN
cord-262253-3ovqhypt	164	15	disorder	disorder	NN
cord-262253-3ovqhypt	164	16	that	that	WDT
cord-262253-3ovqhypt	164	17	,	,	,
cord-262253-3ovqhypt	164	18	if	if	IN
cord-262253-3ovqhypt	164	19	left	leave	VBN
cord-262253-3ovqhypt	164	20	untreated	untreated	JJ
cord-262253-3ovqhypt	164	21	,	,	,
cord-262253-3ovqhypt	164	22	can	can	MD
cord-262253-3ovqhypt	164	23	result	result	VB
cord-262253-3ovqhypt	164	24	in	in	IN
cord-262253-3ovqhypt	164	25	death	death	NN
cord-262253-3ovqhypt	164	26	due	due	IN
cord-262253-3ovqhypt	164	27	to	to	IN
cord-262253-3ovqhypt	164	28	infection	infection	NN
cord-262253-3ovqhypt	164	29	within	within	IN
cord-262253-3ovqhypt	164	30	the	the	DT
cord-262253-3ovqhypt	164	31	first	first	JJ
cord-262253-3ovqhypt	164	32	year	year	NN
cord-262253-3ovqhypt	164	33	of	of	IN
cord-262253-3ovqhypt	164	34	life	life	NN
cord-262253-3ovqhypt	164	35	[	[	-LRB-
cord-262253-3ovqhypt	164	36	81	81	CD
cord-262253-3ovqhypt	164	37	]	]	-RRB-
cord-262253-3ovqhypt	164	38	.	.	.
cord-262253-3ovqhypt	165	1	High	high	JJ
cord-262253-3ovqhypt	165	2	levels	level	NNS
cord-262253-3ovqhypt	165	3	of	of	IN
cord-262253-3ovqhypt	165	4	LL-37	LL-37	NNP
cord-262253-3ovqhypt	165	5	are	be	VBP
cord-262253-3ovqhypt	165	6	likewise	likewise	RB
cord-262253-3ovqhypt	165	7	dangerous	dangerous	JJ
cord-262253-3ovqhypt	165	8	,	,	,
cord-262253-3ovqhypt	165	9	as	as	IN
cord-262253-3ovqhypt	165	10	they	-PRON-	PRP
cord-262253-3ovqhypt	165	11	has	have	VBZ
cord-262253-3ovqhypt	165	12	been	be	VBN
cord-262253-3ovqhypt	165	13	associated	associate	VBN
cord-262253-3ovqhypt	165	14	with	with	IN
cord-262253-3ovqhypt	165	15	the	the	DT
cord-262253-3ovqhypt	165	16	development	development	NN
cord-262253-3ovqhypt	165	17	of	of	IN
cord-262253-3ovqhypt	165	18	plaques	plaque	NNS
cord-262253-3ovqhypt	165	19	in	in	IN
cord-262253-3ovqhypt	165	20	atherosclerosis	atherosclerosis	NN
cord-262253-3ovqhypt	165	21	and	and	CC
cord-262253-3ovqhypt	165	22	other	other	JJ
cord-262253-3ovqhypt	165	23	non	non	JJ
cord-262253-3ovqhypt	165	24	-	-	JJ
cord-262253-3ovqhypt	165	25	infectious	infectious	JJ
cord-262253-3ovqhypt	165	26	diseases	disease	NNS
cord-262253-3ovqhypt	165	27	[	[	-LRB-
cord-262253-3ovqhypt	165	28	98	98	CD
cord-262253-3ovqhypt	165	29	]	]	-RRB-
cord-262253-3ovqhypt	165	30	.	.	.
cord-262253-3ovqhypt	166	1	Protein	protein	NN
cord-262253-3ovqhypt	166	2	analyses	analysis	NNS
cord-262253-3ovqhypt	166	3	comparing	compare	VBG
cord-262253-3ovqhypt	166	4	known	know	VBN
cord-262253-3ovqhypt	166	5	AMPs	amp	NNS
cord-262253-3ovqhypt	166	6	and	and	CC
cord-262253-3ovqhypt	166	7	Aβ	Aβ	NNP
cord-262253-3ovqhypt	166	8	peptides	peptide	NNS
cord-262253-3ovqhypt	166	9	demonstrate	demonstrate	VBP
cord-262253-3ovqhypt	166	10	structural	structural	JJ
cord-262253-3ovqhypt	166	11	similarities	similarity	NNS
cord-262253-3ovqhypt	166	12	between	between	IN
cord-262253-3ovqhypt	166	13	these	these	DT
cord-262253-3ovqhypt	166	14	peptides	peptide	NNS
cord-262253-3ovqhypt	166	15	,	,	,
cord-262253-3ovqhypt	166	16	as	as	RB
cord-262253-3ovqhypt	166	17	well	well	RB
cord-262253-3ovqhypt	166	18	sequential	sequential	JJ
cord-262253-3ovqhypt	166	19	similarities	similarity	NNS
cord-262253-3ovqhypt	166	20	pointing	point	VBG
cord-262253-3ovqhypt	166	21	to	to	IN
cord-262253-3ovqhypt	166	22	a	a	DT
cord-262253-3ovqhypt	166	23	shared	share	VBN
cord-262253-3ovqhypt	166	24	homology	homology	NN
cord-262253-3ovqhypt	166	25	between	between	IN
cord-262253-3ovqhypt	166	26	Aβ	Aβ	NNP
cord-262253-3ovqhypt	166	27	peptides	peptide	NNS
cord-262253-3ovqhypt	166	28	and	and	CC
cord-262253-3ovqhypt	166	29	a	a	DT
cord-262253-3ovqhypt	166	30	specific	specific	JJ
cord-262253-3ovqhypt	166	31	family	family	NN
cord-262253-3ovqhypt	166	32	of	of	IN
cord-262253-3ovqhypt	166	33	bacteriocins	bacteriocins	NNP
cord-262253-3ovqhypt	166	34	[	[	-LRB-
cord-262253-3ovqhypt	166	35	100	100	CD
cord-262253-3ovqhypt	166	36	]	]	-RRB-
cord-262253-3ovqhypt	166	37	.	.	.
cord-262253-3ovqhypt	167	1	This	this	DT
cord-262253-3ovqhypt	167	2	is	be	VBZ
cord-262253-3ovqhypt	167	3	particularly	particularly	RB
cord-262253-3ovqhypt	167	4	notable	notable	JJ
cord-262253-3ovqhypt	167	5	as	as	IN
cord-262253-3ovqhypt	167	6	bacteriocins	bacteriocin	NNS
cord-262253-3ovqhypt	167	7	are	be	VBP
cord-262253-3ovqhypt	167	8	traditionally	traditionally	RB
cord-262253-3ovqhypt	167	9	synthesized	synthesize	VBN
cord-262253-3ovqhypt	167	10	by	by	IN
cord-262253-3ovqhypt	167	11	bacteria	bacteria	NNS
cord-262253-3ovqhypt	167	12	as	as	IN
cord-262253-3ovqhypt	167	13	part	part	NN
cord-262253-3ovqhypt	167	14	of	of	IN
cord-262253-3ovqhypt	167	15	an	an	DT
cord-262253-3ovqhypt	167	16	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	167	17	response	response	NN
cord-262253-3ovqhypt	167	18	to	to	TO
cord-262253-3ovqhypt	167	19	contact	contact	VB
cord-262253-3ovqhypt	167	20	with	with	IN
cord-262253-3ovqhypt	167	21	closely	closely	RB
cord-262253-3ovqhypt	167	22	-	-	HYPH
cord-262253-3ovqhypt	167	23	related	relate	VBN
cord-262253-3ovqhypt	167	24	strains	strain	NNS
cord-262253-3ovqhypt	167	25	[	[	-LRB-
cord-262253-3ovqhypt	167	26	101	101	CD
cord-262253-3ovqhypt	167	27	]	]	-RRB-
cord-262253-3ovqhypt	167	28	.	.	.
cord-262253-3ovqhypt	168	1	If	if	IN
cord-262253-3ovqhypt	168	2	verified	verify	VBN
cord-262253-3ovqhypt	168	3	as	as	IN
cord-262253-3ovqhypt	168	4	an	an	DT
cord-262253-3ovqhypt	168	5	AMP	amp	NN
cord-262253-3ovqhypt	168	6	,	,	,
cord-262253-3ovqhypt	168	7	Aβ	Aβ	NNP
cord-262253-3ovqhypt	168	8	would	would	MD
cord-262253-3ovqhypt	168	9	not	not	RB
cord-262253-3ovqhypt	168	10	be	be	VB
cord-262253-3ovqhypt	168	11	the	the	DT
cord-262253-3ovqhypt	168	12	only	only	JJ
cord-262253-3ovqhypt	168	13	AMP	AMP	NNP
cord-262253-3ovqhypt	168	14	suggested	suggest	VBD
cord-262253-3ovqhypt	168	15	to	to	TO
cord-262253-3ovqhypt	168	16	be	be	VB
cord-262253-3ovqhypt	168	17	involved	involve	VBN
cord-262253-3ovqhypt	168	18	in	in	IN
cord-262253-3ovqhypt	168	19	AD	ad	NN
cord-262253-3ovqhypt	168	20	.	.	.
cord-262253-3ovqhypt	169	1	Often	often	RB
cord-262253-3ovqhypt	169	2	expressed	express	VBN
cord-262253-3ovqhypt	169	3	in	in	IN
cord-262253-3ovqhypt	169	4	epithelial	epithelial	JJ
cord-262253-3ovqhypt	169	5	cells	cell	NNS
cord-262253-3ovqhypt	169	6	,	,	,
cord-262253-3ovqhypt	169	7	β	β	NN
cord-262253-3ovqhypt	169	8	-	-	HYPH
cord-262253-3ovqhypt	169	9	defensin-1	defensin-1	NNP
cord-262253-3ovqhypt	169	10	is	be	VBZ
cord-262253-3ovqhypt	169	11	significantly	significantly	RB
cord-262253-3ovqhypt	169	12	elevated	elevate	VBN
cord-262253-3ovqhypt	169	13	in	in	IN
cord-262253-3ovqhypt	169	14	astrocytes	astrocyte	NNS
cord-262253-3ovqhypt	169	15	of	of	IN
cord-262253-3ovqhypt	169	16	the	the	DT
cord-262253-3ovqhypt	169	17	hippocampus	hippocampus	NN
cord-262253-3ovqhypt	169	18	,	,	,
cord-262253-3ovqhypt	169	19	the	the	DT
cord-262253-3ovqhypt	169	20	choroid	choroid	JJ
cord-262253-3ovqhypt	169	21	plexus	plexus	NN
cord-262253-3ovqhypt	169	22	,	,	,
cord-262253-3ovqhypt	169	23	and	and	CC
cord-262253-3ovqhypt	169	24	the	the	DT
cord-262253-3ovqhypt	169	25	granulovacuolar	granulovacuolar	NNP
cord-262253-3ovqhypt	169	26	degeneration	degeneration	NN
cord-262253-3ovqhypt	169	27	structures	structure	NNS
cord-262253-3ovqhypt	169	28	of	of	IN
cord-262253-3ovqhypt	169	29	AD	ad	NN
cord-262253-3ovqhypt	169	30	brain	brain	NN
cord-262253-3ovqhypt	169	31	samples	sample	NNS
cord-262253-3ovqhypt	169	32	[	[	-LRB-
cord-262253-3ovqhypt	169	33	102	102	CD
cord-262253-3ovqhypt	169	34	]	]	-RRB-
cord-262253-3ovqhypt	169	35	.	.	.
cord-262253-3ovqhypt	170	1	In	in	IN
cord-262253-3ovqhypt	170	2	vitro	vitro	FW
cord-262253-3ovqhypt	170	3	studies	study	NNS
cord-262253-3ovqhypt	170	4	suggest	suggest	VBP
cord-262253-3ovqhypt	170	5	the	the	DT
cord-262253-3ovqhypt	170	6	ability	ability	NN
cord-262253-3ovqhypt	170	7	of	of	IN
cord-262253-3ovqhypt	170	8	Aβ	Aβ	NNP
cord-262253-3ovqhypt	170	9	peptides	peptide	NNS
cord-262253-3ovqhypt	170	10	to	to	TO
cord-262253-3ovqhypt	170	11	be	be	VB
cord-262253-3ovqhypt	170	12	an	an	DT
cord-262253-3ovqhypt	170	13	AMP	amp	NN
cord-262253-3ovqhypt	170	14	,	,	,
cord-262253-3ovqhypt	170	15	and	and	CC
cord-262253-3ovqhypt	170	16	inhibit	inhibit	VB
cord-262253-3ovqhypt	170	17	growth	growth	NN
cord-262253-3ovqhypt	170	18	of	of	IN
cord-262253-3ovqhypt	170	19	a	a	DT
cord-262253-3ovqhypt	170	20	number	number	NN
cord-262253-3ovqhypt	170	21	of	of	IN
cord-262253-3ovqhypt	170	22	bacteria	bacteria	NNS
cord-262253-3ovqhypt	170	23	and	and	CC
cord-262253-3ovqhypt	170	24	viruses	virus	NNS
cord-262253-3ovqhypt	170	25	.	.	.
cord-262253-3ovqhypt	171	1	In	in	IN
cord-262253-3ovqhypt	171	2	respect	respect	NN
cord-262253-3ovqhypt	171	3	to	to	IN
cord-262253-3ovqhypt	171	4	the	the	DT
cord-262253-3ovqhypt	171	5	latter	latter	JJ
cord-262253-3ovqhypt	171	6	,	,	,
cord-262253-3ovqhypt	171	7	Aβ	Aβ	NNP
cord-262253-3ovqhypt	171	8	has	have	VBZ
cord-262253-3ovqhypt	171	9	been	be	VBN
cord-262253-3ovqhypt	171	10	shown	show	VBN
cord-262253-3ovqhypt	171	11	to	to	TO
cord-262253-3ovqhypt	171	12	have	have	VB
cord-262253-3ovqhypt	171	13	antiviral	antiviral	JJ
cord-262253-3ovqhypt	171	14	activity	activity	NN
cord-262253-3ovqhypt	171	15	against	against	IN
cord-262253-3ovqhypt	171	16	both	both	CC
cord-262253-3ovqhypt	171	17	HSV-1	HSV-1	NNS
cord-262253-3ovqhypt	171	18	and	and	CC
cord-262253-3ovqhypt	171	19	the	the	DT
cord-262253-3ovqhypt	171	20	influenza	influenza	NN
cord-262253-3ovqhypt	171	21	virus	virus	NN
cord-262253-3ovqhypt	171	22	A	a	NN
cord-262253-3ovqhypt	171	23	by	by	IN
cord-262253-3ovqhypt	171	24	inhibiting	inhibit	VBG
cord-262253-3ovqhypt	171	25	the	the	DT
cord-262253-3ovqhypt	171	26	infectivity	infectivity	NN
cord-262253-3ovqhypt	171	27	of	of	IN
cord-262253-3ovqhypt	171	28	HSV-1	HSV-1	NNP
cord-262253-3ovqhypt	171	29	[	[	-LRB-
cord-262253-3ovqhypt	171	30	82	82	CD
cord-262253-3ovqhypt	171	31	]	]	-RRB-
cord-262253-3ovqhypt	171	32	,	,	,
cord-262253-3ovqhypt	171	33	influenza	influenza	NN
cord-262253-3ovqhypt	171	34	virus	virus	NN
cord-262253-3ovqhypt	171	35	A	A	NNP
cord-262253-3ovqhypt	171	36	[	[	-LRB-
cord-262253-3ovqhypt	171	37	103	103	CD
cord-262253-3ovqhypt	171	38	]	]	-RRB-
cord-262253-3ovqhypt	171	39	,	,	.
cord-262253-3ovqhypt	172	1	H3N2	H3N2	NNP
cord-262253-3ovqhypt	172	2	[	[	-LRB-
cord-262253-3ovqhypt	172	3	103	103	CD
cord-262253-3ovqhypt	172	4	]	]	-RRB-
cord-262253-3ovqhypt	172	5	and	and	CC
cord-262253-3ovqhypt	172	6	H1N1	H1N1	NNP
cord-262253-3ovqhypt	172	7	[	[	-LRB-
cord-262253-3ovqhypt	172	8	103	103	CD
cord-262253-3ovqhypt	172	9	]	]	-RRB-
cord-262253-3ovqhypt	172	10	.	.	.
cord-262253-3ovqhypt	173	1	Researchers	researcher	NNS
cord-262253-3ovqhypt	173	2	found	find	VBD
cord-262253-3ovqhypt	173	3	that	that	IN
cord-262253-3ovqhypt	173	4	in	in	IN
cord-262253-3ovqhypt	173	5	mouse	mouse	NN
cord-262253-3ovqhypt	173	6	and	and	CC
cord-262253-3ovqhypt	173	7	human	human	JJ
cord-262253-3ovqhypt	173	8	neural	neural	JJ
cord-262253-3ovqhypt	173	9	cell	cell	NN
cord-262253-3ovqhypt	173	10	cultures	culture	NNS
cord-262253-3ovqhypt	173	11	,	,	,
cord-262253-3ovqhypt	173	12	Aβ	Aβ	NNP
cord-262253-3ovqhypt	173	13	peptide	peptide	JJ
cord-262253-3ovqhypt	173	14	deposition	deposition	NN
cord-262253-3ovqhypt	173	15	was	be	VBD
cord-262253-3ovqhypt	173	16	accelerated	accelerate	VBN
cord-262253-3ovqhypt	173	17	in	in	IN
cord-262253-3ovqhypt	173	18	response	response	NN
cord-262253-3ovqhypt	173	19	to	to	IN
cord-262253-3ovqhypt	173	20	HSV-1	HSV-1	NNP
cord-262253-3ovqhypt	173	21	and	and	CC
cord-262253-3ovqhypt	173	22	HHV6	HHV6	NNP
cord-262253-3ovqhypt	173	23	infection	infection	NN
cord-262253-3ovqhypt	173	24	,	,	,
cord-262253-3ovqhypt	173	25	with	with	IN
cord-262253-3ovqhypt	173	26	the	the	DT
cord-262253-3ovqhypt	173	27	oligomers	oligomer	NNS
cord-262253-3ovqhypt	173	28	binding	bind	VBG
cord-262253-3ovqhypt	173	29	to	to	IN
cord-262253-3ovqhypt	173	30	the	the	DT
cord-262253-3ovqhypt	173	31	viruses	virus	NNS
cord-262253-3ovqhypt	173	32	as	as	IN
cord-262253-3ovqhypt	173	33	part	part	NN
cord-262253-3ovqhypt	173	34	of	of	IN
cord-262253-3ovqhypt	173	35	a	a	DT
cord-262253-3ovqhypt	173	36	protective	protective	JJ
cord-262253-3ovqhypt	173	37	entrapment	entrapment	NN
cord-262253-3ovqhypt	173	38	mechanism	mechanism	NN
cord-262253-3ovqhypt	173	39	[	[	-LRB-
cord-262253-3ovqhypt	173	40	104	104	CD
cord-262253-3ovqhypt	173	41	]	]	-RRB-
cord-262253-3ovqhypt	173	42	.	.	.
cord-262253-3ovqhypt	174	1	Aβ	aβ	NN
cord-262253-3ovqhypt	174	2	peptides	peptide	NNS
cord-262253-3ovqhypt	174	3	have	have	VBP
cord-262253-3ovqhypt	174	4	also	also	RB
cord-262253-3ovqhypt	174	5	been	be	VBN
cord-262253-3ovqhypt	174	6	shown	show	VBN
cord-262253-3ovqhypt	174	7	to	to	TO
cord-262253-3ovqhypt	174	8	have	have	VB
cord-262253-3ovqhypt	174	9	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	174	10	properties	property	NNS
cord-262253-3ovqhypt	174	11	against	against	IN
cord-262253-3ovqhypt	174	12	both	both	CC
cord-262253-3ovqhypt	174	13	Gram	gram	NN
cord-262253-3ovqhypt	174	14	-	-	HYPH
cord-262253-3ovqhypt	174	15	positive	positive	JJ
cord-262253-3ovqhypt	174	16	and	and	CC
cord-262253-3ovqhypt	174	17	Gram	gram	NN
cord-262253-3ovqhypt	174	18	-	-	HYPH
cord-262253-3ovqhypt	174	19	negative	negative	JJ
cord-262253-3ovqhypt	174	20	bacteria	bacteria	NNS
cord-262253-3ovqhypt	174	21	,	,	,
cord-262253-3ovqhypt	174	22	including	include	VBG
cord-262253-3ovqhypt	174	23	Enterococcus	Enterococcus	NNP
cord-262253-3ovqhypt	174	24	faecalis	faecalis	NNP
cord-262253-3ovqhypt	174	25	,	,	,
cord-262253-3ovqhypt	174	26	Escherichia	Escherichia	NNP
cord-262253-3ovqhypt	174	27	coli	coli	NNS
cord-262253-3ovqhypt	174	28	,	,	,
cord-262253-3ovqhypt	174	29	Listeria	Listeria	NNP
cord-262253-3ovqhypt	174	30	monocytogenes	monocytogenes	NN
cord-262253-3ovqhypt	174	31	,	,	,
cord-262253-3ovqhypt	174	32	Salmonella	Salmonella	NNP
cord-262253-3ovqhypt	174	33	typhimurium	typhimurium	NN
cord-262253-3ovqhypt	174	34	,	,	,
cord-262253-3ovqhypt	174	35	Staphylococcus	Staphylococcus	NNP
cord-262253-3ovqhypt	174	36	aureus	aureus	NN
cord-262253-3ovqhypt	174	37	,	,	,
cord-262253-3ovqhypt	174	38	Staphylococcus	Staphylococcus	NNP
cord-262253-3ovqhypt	174	39	epidermidis	epidermidi	NNS
cord-262253-3ovqhypt	174	40	,	,	,
cord-262253-3ovqhypt	174	41	Streptococcus	Streptococcus	NNP
cord-262253-3ovqhypt	174	42	agalactiae	agalactiae	NN
cord-262253-3ovqhypt	174	43	and	and	CC
cord-262253-3ovqhypt	174	44	Streptococcus	Streptococcus	NNP
cord-262253-3ovqhypt	174	45	pneumoniae	pneumoniae	NN
cord-262253-3ovqhypt	174	46	[	[	-LRB-
cord-262253-3ovqhypt	174	47	30	30	CD
cord-262253-3ovqhypt	174	48	]	]	-RRB-
cord-262253-3ovqhypt	174	49	.	.	.
cord-262253-3ovqhypt	175	1	In	in	IN
cord-262253-3ovqhypt	175	2	a	a	DT
cord-262253-3ovqhypt	175	3	study	study	NN
cord-262253-3ovqhypt	175	4	comparing	compare	VBG
cord-262253-3ovqhypt	175	5	Aβ	Aβ	NNP
cord-262253-3ovqhypt	175	6	peptides	peptide	NNS
cord-262253-3ovqhypt	175	7	and	and	CC
cord-262253-3ovqhypt	175	8	LL-37	LL-37	NNP
cord-262253-3ovqhypt	175	9	,	,	,
cord-262253-3ovqhypt	175	10	Soscia	Soscia	NNP
cord-262253-3ovqhypt	175	11	et	et	NNP
cord-262253-3ovqhypt	175	12	al	al	NNP
cord-262253-3ovqhypt	175	13	.	.	.
cord-262253-3ovqhypt	176	1	found	find	VBD
cord-262253-3ovqhypt	176	2	that	that	IN
cord-262253-3ovqhypt	176	3	,	,	,
cord-262253-3ovqhypt	176	4	against	against	IN
cord-262253-3ovqhypt	176	5	eight	eight	CD
cord-262253-3ovqhypt	176	6	different	different	JJ
cord-262253-3ovqhypt	176	7	bacteria	bacteria	NNS
cord-262253-3ovqhypt	176	8	and	and	CC
cord-262253-3ovqhypt	176	9	viruses	virus	NNS
cord-262253-3ovqhypt	176	10	,	,	,
cord-262253-3ovqhypt	176	11	Aβ	Aβ	NNP
cord-262253-3ovqhypt	176	12	peptides	peptide	NNS
cord-262253-3ovqhypt	176	13	demonstrated	demonstrate	VBD
cord-262253-3ovqhypt	176	14	an	an	DT
cord-262253-3ovqhypt	176	15	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	176	16	activity	activity	NN
cord-262253-3ovqhypt	176	17	equivalent	equivalent	JJ
cord-262253-3ovqhypt	176	18	to	to	IN
cord-262253-3ovqhypt	176	19	,	,	,
cord-262253-3ovqhypt	176	20	and	and	CC
cord-262253-3ovqhypt	176	21	sometimes	sometimes	RB
cord-262253-3ovqhypt	176	22	even	even	RB
cord-262253-3ovqhypt	176	23	greater	great	JJR
cord-262253-3ovqhypt	176	24	than	than	IN
cord-262253-3ovqhypt	176	25	,	,	,
cord-262253-3ovqhypt	176	26	the	the	DT
cord-262253-3ovqhypt	176	27	known	know	VBN
cord-262253-3ovqhypt	176	28	AMP	AMP	NNP
cord-262253-3ovqhypt	176	29	LL-37	LL-37	NNP
cord-262253-3ovqhypt	176	30	.	.	.
cord-262253-3ovqhypt	177	1	The	the	DT
cord-262253-3ovqhypt	177	2	same	same	JJ
cord-262253-3ovqhypt	177	3	study	study	NN
cord-262253-3ovqhypt	177	4	also	also	RB
cord-262253-3ovqhypt	177	5	found	find	VBD
cord-262253-3ovqhypt	177	6	that	that	IN
cord-262253-3ovqhypt	177	7	,	,	,
cord-262253-3ovqhypt	177	8	when	when	WRB
cord-262253-3ovqhypt	177	9	comparing	compare	VBG
cord-262253-3ovqhypt	177	10	the	the	DT
cord-262253-3ovqhypt	177	11	brain	brain	NN
cord-262253-3ovqhypt	177	12	homogenates	homogenate	NNS
cord-262253-3ovqhypt	177	13	of	of	IN
cord-262253-3ovqhypt	177	14	Aβ	aβ	NN
cord-262253-3ovqhypt	177	15	-	-	HYPH
cord-262253-3ovqhypt	177	16	enriched	enrich	VBN
cord-262253-3ovqhypt	177	17	areas	area	NNS
cord-262253-3ovqhypt	177	18	from	from	IN
cord-262253-3ovqhypt	177	19	both	both	DT
cord-262253-3ovqhypt	177	20	AD	ad	NN
cord-262253-3ovqhypt	177	21	and	and	CC
cord-262253-3ovqhypt	177	22	non	non	JJ
cord-262253-3ovqhypt	177	23	-	-	JJ
cord-262253-3ovqhypt	177	24	AD	ad	JJ
cord-262253-3ovqhypt	177	25	brains	brain	NNS
cord-262253-3ovqhypt	177	26	,	,	,
cord-262253-3ovqhypt	177	27	the	the	DT
cord-262253-3ovqhypt	177	28	AD	ad	NN
cord-262253-3ovqhypt	177	29	brain	brain	NN
cord-262253-3ovqhypt	177	30	samples	sample	NNS
cord-262253-3ovqhypt	177	31	had	have	VBD
cord-262253-3ovqhypt	177	32	elevated	elevate	VBN
cord-262253-3ovqhypt	177	33	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	177	34	and	and	CC
cord-262253-3ovqhypt	177	35	antiviral	antiviral	JJ
cord-262253-3ovqhypt	177	36	activity	activity	NN
cord-262253-3ovqhypt	177	37	.	.	.
cord-262253-3ovqhypt	178	1	These	these	DT
cord-262253-3ovqhypt	178	2	discrepancies	discrepancy	NNS
cord-262253-3ovqhypt	178	3	were	be	VBD
cord-262253-3ovqhypt	178	4	eliminated	eliminate	VBN
cord-262253-3ovqhypt	178	5	once	once	IN
cord-262253-3ovqhypt	178	6	the	the	DT
cord-262253-3ovqhypt	178	7	AD	ad	NN
cord-262253-3ovqhypt	178	8	brain	brain	NN
cord-262253-3ovqhypt	178	9	tissues	tissue	NNS
cord-262253-3ovqhypt	178	10	were	be	VBD
cord-262253-3ovqhypt	178	11	immunodepleted	immunodeplete	VBN
cord-262253-3ovqhypt	178	12	using	use	VBG
cord-262253-3ovqhypt	178	13	anti	anti	JJ
cord-262253-3ovqhypt	178	14	-	-	JJ
cord-262253-3ovqhypt	178	15	Aβ	aβ	JJ
cord-262253-3ovqhypt	178	16	antibodies	antibody	NNS
cord-262253-3ovqhypt	178	17	.	.	.
cord-262253-3ovqhypt	179	1	It	-PRON-	PRP
cord-262253-3ovqhypt	179	2	is	be	VBZ
cord-262253-3ovqhypt	179	3	important	important	JJ
cord-262253-3ovqhypt	179	4	to	to	TO
cord-262253-3ovqhypt	179	5	consider	consider	VB
cord-262253-3ovqhypt	179	6	the	the	DT
cord-262253-3ovqhypt	179	7	sequence	sequence	NN
cord-262253-3ovqhypt	179	8	length	length	NN
cord-262253-3ovqhypt	179	9	of	of	IN
cord-262253-3ovqhypt	179	10	the	the	DT
cord-262253-3ovqhypt	179	11	Aβ	Aβ	NNP
cord-262253-3ovqhypt	179	12	peptide	peptide	NN
cord-262253-3ovqhypt	179	13	when	when	WRB
cord-262253-3ovqhypt	179	14	examining	examine	VBG
cord-262253-3ovqhypt	179	15	its	-PRON-	PRP$
cord-262253-3ovqhypt	179	16	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	179	17	capabilities	capability	NNS
cord-262253-3ovqhypt	179	18	,	,	,
cord-262253-3ovqhypt	179	19	as	as	IN
cord-262253-3ovqhypt	179	20	Aβ	Aβ	NNP
cord-262253-3ovqhypt	179	21	1	1	CD
cord-262253-3ovqhypt	179	22	-	-	SYM
cord-262253-3ovqhypt	179	23	42	42	CD
cord-262253-3ovqhypt	179	24	was	be	VBD
cord-262253-3ovqhypt	179	25	shown	show	VBN
cord-262253-3ovqhypt	179	26	to	to	TO
cord-262253-3ovqhypt	179	27	be	be	VB
cord-262253-3ovqhypt	179	28	capable	capable	JJ
cord-262253-3ovqhypt	179	29	of	of	IN
cord-262253-3ovqhypt	179	30	binding	bind	VBG
cord-262253-3ovqhypt	179	31	to	to	IN
cord-262253-3ovqhypt	179	32	the	the	DT
cord-262253-3ovqhypt	179	33	surface	surface	NN
cord-262253-3ovqhypt	179	34	of	of	IN
cord-262253-3ovqhypt	179	35	bacteria	bacteria	NNS
cord-262253-3ovqhypt	179	36	and	and	CC
cord-262253-3ovqhypt	179	37	aggregating	aggregate	VBG
cord-262253-3ovqhypt	179	38	into	into	IN
cord-262253-3ovqhypt	179	39	clusters	cluster	NNS
cord-262253-3ovqhypt	179	40	,	,	,
cord-262253-3ovqhypt	179	41	whereas	whereas	IN
cord-262253-3ovqhypt	179	42	other	other	JJ
cord-262253-3ovqhypt	179	43	peptide	peptide	NN
cord-262253-3ovqhypt	179	44	lengths	length	NNS
cord-262253-3ovqhypt	179	45	were	be	VBD
cord-262253-3ovqhypt	179	46	not	not	RB
cord-262253-3ovqhypt	179	47	[	[	-LRB-
cord-262253-3ovqhypt	179	48	105	105	CD
cord-262253-3ovqhypt	179	49	]	]	-RRB-
cord-262253-3ovqhypt	179	50	.	.	.
cord-262253-3ovqhypt	180	1	Animal	animal	NN
cord-262253-3ovqhypt	180	2	studies	study	NNS
cord-262253-3ovqhypt	180	3	have	have	VBP
cord-262253-3ovqhypt	180	4	further	further	RB
cord-262253-3ovqhypt	180	5	evidenced	evidence	VBN
cord-262253-3ovqhypt	180	6	the	the	DT
cord-262253-3ovqhypt	180	7	important	important	JJ
cord-262253-3ovqhypt	180	8	potential	potential	JJ
cord-262253-3ovqhypt	180	9	role	role	NN
cord-262253-3ovqhypt	180	10	that	that	WDT
cord-262253-3ovqhypt	180	11	Aβ	Aβ	NNP
cord-262253-3ovqhypt	180	12	peptides	peptide	NNS
cord-262253-3ovqhypt	180	13	have	have	VBP
cord-262253-3ovqhypt	180	14	in	in	IN
cord-262253-3ovqhypt	180	15	protecting	protect	VBG
cord-262253-3ovqhypt	180	16	against	against	IN
cord-262253-3ovqhypt	180	17	infections	infection	NNS
cord-262253-3ovqhypt	180	18	.	.	.
cord-262253-3ovqhypt	181	1	In	in	IN
cord-262253-3ovqhypt	181	2	a	a	DT
cord-262253-3ovqhypt	181	3	2016	2016	CD
cord-262253-3ovqhypt	181	4	study	study	NN
cord-262253-3ovqhypt	181	5	,	,	,
cord-262253-3ovqhypt	181	6	researchers	researcher	NNS
cord-262253-3ovqhypt	181	7	tested	test	VBD
cord-262253-3ovqhypt	181	8	Aβ	Aβ	NNP
cord-262253-3ovqhypt	181	9	's	's	POS
cord-262253-3ovqhypt	181	10	functionality	functionality	NN
cord-262253-3ovqhypt	181	11	as	as	IN
cord-262253-3ovqhypt	181	12	an	an	DT
cord-262253-3ovqhypt	181	13	AMP	AMP	NNP
cord-262253-3ovqhypt	181	14	in	in	IN
cord-262253-3ovqhypt	181	15	mice	mouse	NNS
cord-262253-3ovqhypt	181	16	and	and	CC
cord-262253-3ovqhypt	181	17	nematode	nematode	NN
cord-262253-3ovqhypt	181	18	models	model	NNS
cord-262253-3ovqhypt	181	19	[	[	-LRB-
cord-262253-3ovqhypt	181	20	106	106	CD
cord-262253-3ovqhypt	181	21	]	]	-RRB-
cord-262253-3ovqhypt	181	22	.	.	.
cord-262253-3ovqhypt	182	1	Kumar	Kumar	NNP
cord-262253-3ovqhypt	182	2	et	et	NNP
cord-262253-3ovqhypt	182	3	al	al	NNP
cord-262253-3ovqhypt	182	4	.	.	.
cord-262253-3ovqhypt	183	1	found	find	VBD
cord-262253-3ovqhypt	183	2	that	that	IN
cord-262253-3ovqhypt	183	3	transgenic	transgenic	JJ
cord-262253-3ovqhypt	183	4	5XFAD	5xfad	CD
cord-262253-3ovqhypt	183	5	mice	mouse	NNS
cord-262253-3ovqhypt	183	6	,	,	,
cord-262253-3ovqhypt	183	7	which	which	WDT
cord-262253-3ovqhypt	183	8	constitutively	constitutively	RB
cord-262253-3ovqhypt	183	9	express	express	VBP
cord-262253-3ovqhypt	183	10	human	human	JJ
cord-262253-3ovqhypt	183	11	Aβ	Aβ	NNP
cord-262253-3ovqhypt	183	12	peptides	peptide	NNS
cord-262253-3ovqhypt	183	13	,	,	,
cord-262253-3ovqhypt	183	14	survived	survive	VBD
cord-262253-3ovqhypt	183	15	significantly	significantly	RB
cord-262253-3ovqhypt	183	16	longer	long	RBR
cord-262253-3ovqhypt	183	17	than	than	IN
cord-262253-3ovqhypt	183	18	wild	wild	JJ
cord-262253-3ovqhypt	183	19	-	-	HYPH
cord-262253-3ovqhypt	183	20	type	type	NN
cord-262253-3ovqhypt	183	21	mice	mouse	NNS
cord-262253-3ovqhypt	183	22	after	after	IN
cord-262253-3ovqhypt	183	23	the	the	DT
cord-262253-3ovqhypt	183	24	injection	injection	NN
cord-262253-3ovqhypt	183	25	of	of	IN
cord-262253-3ovqhypt	183	26	Salmonella	Salmonella	NNP
cord-262253-3ovqhypt	183	27	typhimurium	typhimurium	NN
cord-262253-3ovqhypt	183	28	into	into	IN
cord-262253-3ovqhypt	183	29	their	-PRON-	PRP$
cord-262253-3ovqhypt	183	30	brains	brain	NNS
cord-262253-3ovqhypt	183	31	.	.	.
cord-262253-3ovqhypt	184	1	The	the	DT
cord-262253-3ovqhypt	184	2	5XFAD	5xfad	CD
cord-262253-3ovqhypt	184	3	mice	mouse	NNS
cord-262253-3ovqhypt	184	4	were	be	VBD
cord-262253-3ovqhypt	184	5	observed	observe	VBN
cord-262253-3ovqhypt	184	6	to	to	TO
cord-262253-3ovqhypt	184	7	have	have	VB
cord-262253-3ovqhypt	184	8	accelerated	accelerate	VBN
cord-262253-3ovqhypt	184	9	Aβ	Aβ	NNP
cord-262253-3ovqhypt	184	10	deposition	deposition	NN
cord-262253-3ovqhypt	184	11	that	that	WDT
cord-262253-3ovqhypt	184	12	closely	closely	RB
cord-262253-3ovqhypt	184	13	co	co	NN
cord-262253-3ovqhypt	184	14	-	-	VBN
cord-262253-3ovqhypt	184	15	localized	localize	VBN
cord-262253-3ovqhypt	184	16	with	with	IN
cord-262253-3ovqhypt	184	17	the	the	DT
cord-262253-3ovqhypt	184	18	bacteria	bacteria	NNS
cord-262253-3ovqhypt	184	19	,	,	,
cord-262253-3ovqhypt	184	20	reducing	reduce	VBG
cord-262253-3ovqhypt	184	21	their	-PRON-	PRP$
cord-262253-3ovqhypt	184	22	cerebral	cerebral	JJ
cord-262253-3ovqhypt	184	23	viral	viral	JJ
cord-262253-3ovqhypt	184	24	load	load	NN
cord-262253-3ovqhypt	184	25	compared	compare	VBN
cord-262253-3ovqhypt	184	26	to	to	IN
cord-262253-3ovqhypt	184	27	wild	wild	JJ
cord-262253-3ovqhypt	184	28	-	-	HYPH
cord-262253-3ovqhypt	184	29	type	type	NN
cord-262253-3ovqhypt	184	30	mice	mouse	NNS
cord-262253-3ovqhypt	184	31	.	.	.
cord-262253-3ovqhypt	185	1	These	these	DT
cord-262253-3ovqhypt	185	2	findings	finding	NNS
cord-262253-3ovqhypt	185	3	were	be	VBD
cord-262253-3ovqhypt	185	4	recapitulated	recapitulate	VBN
cord-262253-3ovqhypt	185	5	again	again	RB
cord-262253-3ovqhypt	185	6	in	in	IN
cord-262253-3ovqhypt	185	7	worm	worm	NN
cord-262253-3ovqhypt	185	8	models	model	NNS
cord-262253-3ovqhypt	185	9	,	,	,
cord-262253-3ovqhypt	185	10	as	as	IN
cord-262253-3ovqhypt	185	11	nematodes	nematode	NNS
cord-262253-3ovqhypt	185	12	expressing	express	VBG
cord-262253-3ovqhypt	185	13	Aβ	Aβ	NNP
cord-262253-3ovqhypt	185	14	were	be	VBD
cord-262253-3ovqhypt	185	15	found	find	VBN
cord-262253-3ovqhypt	185	16	to	to	TO
cord-262253-3ovqhypt	185	17	have	have	VB
cord-262253-3ovqhypt	185	18	increased	increase	VBN
cord-262253-3ovqhypt	185	19	survival	survival	NN
cord-262253-3ovqhypt	185	20	following	follow	VBG
cord-262253-3ovqhypt	185	21	fungal	fungal	JJ
cord-262253-3ovqhypt	185	22	infection	infection	NN
cord-262253-3ovqhypt	185	23	of	of	IN
cord-262253-3ovqhypt	185	24	C.	C.	NNP
cord-262253-3ovqhypt	185	25	albicans	albican	NNS
cord-262253-3ovqhypt	185	26	,	,	,
cord-262253-3ovqhypt	185	27	compared	compare	VBN
cord-262253-3ovqhypt	185	28	to	to	IN
cord-262253-3ovqhypt	185	29	nematodes	nematode	NNS
cord-262253-3ovqhypt	185	30	that	that	WDT
cord-262253-3ovqhypt	185	31	did	do	VBD
cord-262253-3ovqhypt	185	32	not	not	RB
cord-262253-3ovqhypt	185	33	produce	produce	VB
cord-262253-3ovqhypt	185	34	Aβ	Aβ	NNP
cord-262253-3ovqhypt	185	35	peptides	peptide	NNS
cord-262253-3ovqhypt	185	36	.	.	.
cord-262253-3ovqhypt	186	1	Additionally	additionally	RB
cord-262253-3ovqhypt	186	2	,	,	,
cord-262253-3ovqhypt	186	3	it	-PRON-	PRP
cord-262253-3ovqhypt	186	4	has	have	VBZ
cord-262253-3ovqhypt	186	5	been	be	VBN
cord-262253-3ovqhypt	186	6	observed	observe	VBN
cord-262253-3ovqhypt	186	7	that	that	IN
cord-262253-3ovqhypt	186	8	impaired	impaired	JJ
cord-262253-3ovqhypt	186	9	mice	mouse	NNS
cord-262253-3ovqhypt	186	10	that	that	WDT
cord-262253-3ovqhypt	186	11	lacked	lack	VBD
cord-262253-3ovqhypt	186	12	the	the	DT
cord-262253-3ovqhypt	186	13	ability	ability	NN
cord-262253-3ovqhypt	186	14	to	to	TO
cord-262253-3ovqhypt	186	15	generate	generate	VB
cord-262253-3ovqhypt	186	16	Aβ	Aβ	NNP
cord-262253-3ovqhypt	186	17	peptides	peptide	NNS
cord-262253-3ovqhypt	186	18	have	have	VBP
cord-262253-3ovqhypt	186	19	been	be	VBN
cord-262253-3ovqhypt	186	20	shown	show	VBN
cord-262253-3ovqhypt	186	21	to	to	TO
cord-262253-3ovqhypt	186	22	have	have	VB
cord-262253-3ovqhypt	186	23	increased	increase	VBN
cord-262253-3ovqhypt	186	24	postpartum	postpartum	NN
cord-262253-3ovqhypt	186	25	mortality	mortality	NN
cord-262253-3ovqhypt	186	26	,	,	,
cord-262253-3ovqhypt	186	27	which	which	WDT
cord-262253-3ovqhypt	186	28	was	be	VBD
cord-262253-3ovqhypt	186	29	only	only	RB
cord-262253-3ovqhypt	186	30	reversed	reverse	VBN
cord-262253-3ovqhypt	186	31	by	by	IN
cord-262253-3ovqhypt	186	32	maintaining	maintain	VBG
cord-262253-3ovqhypt	186	33	a	a	DT
cord-262253-3ovqhypt	186	34	sterile	sterile	JJ
cord-262253-3ovqhypt	186	35	environment	environment	NN
cord-262253-3ovqhypt	186	36	[	[	-LRB-
cord-262253-3ovqhypt	186	37	107	107	CD
cord-262253-3ovqhypt	186	38	]	]	-RRB-
cord-262253-3ovqhypt	186	39	.	.	.
cord-262253-3ovqhypt	187	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	187	2	,	,	,
cord-262253-3ovqhypt	187	3	APP	app	NN
cord-262253-3ovqhypt	187	4	knockout	knockout	NN
cord-262253-3ovqhypt	187	5	mice	mouse	NNS
cord-262253-3ovqhypt	187	6	were	be	VBD
cord-262253-3ovqhypt	187	7	also	also	RB
cord-262253-3ovqhypt	187	8	observed	observe	VBN
cord-262253-3ovqhypt	187	9	to	to	TO
cord-262253-3ovqhypt	187	10	have	have	VB
cord-262253-3ovqhypt	187	11	increased	increase	VBN
cord-262253-3ovqhypt	187	12	rates	rate	NNS
cord-262253-3ovqhypt	187	13	of	of	IN
cord-262253-3ovqhypt	187	14	mortality	mortality	NN
cord-262253-3ovqhypt	187	15	.	.	.
cord-262253-3ovqhypt	188	1	Altogether	altogether	RB
cord-262253-3ovqhypt	188	2	,	,	,
cord-262253-3ovqhypt	188	3	these	these	DT
cord-262253-3ovqhypt	188	4	studies	study	NNS
cord-262253-3ovqhypt	188	5	support	support	VBP
cord-262253-3ovqhypt	188	6	the	the	DT
cord-262253-3ovqhypt	188	7	notion	notion	NN
cord-262253-3ovqhypt	188	8	that	that	IN
cord-262253-3ovqhypt	188	9	Aβ	Aβ	NNP
cord-262253-3ovqhypt	188	10	peptides	peptide	NNS
cord-262253-3ovqhypt	188	11	are	be	VBP
cord-262253-3ovqhypt	188	12	an	an	DT
cord-262253-3ovqhypt	188	13	AMP	amp	NN
cord-262253-3ovqhypt	188	14	,	,	,
cord-262253-3ovqhypt	188	15	and	and	CC
cord-262253-3ovqhypt	188	16	an	an	DT
cord-262253-3ovqhypt	188	17	integral	integral	JJ
cord-262253-3ovqhypt	188	18	part	part	NN
cord-262253-3ovqhypt	188	19	of	of	IN
cord-262253-3ovqhypt	188	20	the	the	DT
cord-262253-3ovqhypt	188	21	brain	brain	NN
cord-262253-3ovqhypt	188	22	's	's	POS
cord-262253-3ovqhypt	188	23	innate	innate	JJ
cord-262253-3ovqhypt	188	24	immune	immune	JJ
cord-262253-3ovqhypt	188	25	response	response	NN
cord-262253-3ovqhypt	188	26	against	against	IN
cord-262253-3ovqhypt	188	27	invading	invade	VBG
cord-262253-3ovqhypt	188	28	pathogens	pathogen	NNS
cord-262253-3ovqhypt	188	29	.	.	.
cord-262253-3ovqhypt	189	1	The	the	DT
cord-262253-3ovqhypt	189	2	mechanism	mechanism	NN
cord-262253-3ovqhypt	189	3	by	by	IN
cord-262253-3ovqhypt	189	4	which	which	WDT
cord-262253-3ovqhypt	189	5	Aβ	Aβ	NNP
cord-262253-3ovqhypt	189	6	peptides	peptide	NNS
cord-262253-3ovqhypt	189	7	have	have	VBP
cord-262253-3ovqhypt	189	8	been	be	VBN
cord-262253-3ovqhypt	189	9	suggested	suggest	VBN
cord-262253-3ovqhypt	189	10	to	to	TO
cord-262253-3ovqhypt	189	11	exert	exert	VB
cord-262253-3ovqhypt	189	12	their	-PRON-	PRP$
cord-262253-3ovqhypt	189	13	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	189	14	and	and	CC
cord-262253-3ovqhypt	189	15	antiviral	antiviral	JJ
cord-262253-3ovqhypt	189	16	effect	effect	NN
cord-262253-3ovqhypt	189	17	has	have	VBZ
cord-262253-3ovqhypt	189	18	been	be	VBN
cord-262253-3ovqhypt	189	19	based	base	VBN
cord-262253-3ovqhypt	189	20	on	on	IN
cord-262253-3ovqhypt	189	21	entrapment	entrapment	NN
cord-262253-3ovqhypt	189	22	and	and	CC
cord-262253-3ovqhypt	189	23	lytic	lytic	JJ
cord-262253-3ovqhypt	189	24	activity	activity	NN
cord-262253-3ovqhypt	189	25	,	,	,
cord-262253-3ovqhypt	189	26	as	as	IN
cord-262253-3ovqhypt	189	27	illustrated	illustrate	VBN
cord-262253-3ovqhypt	189	28	in	in	IN
cord-262253-3ovqhypt	189	29	Figure	Figure	NNP
cord-262253-3ovqhypt	189	30	2	2	CD
cord-262253-3ovqhypt	189	31	.	.	.
cord-262253-3ovqhypt	190	1	Being	be	VBG
cord-262253-3ovqhypt	190	2	a	a	DT
cord-262253-3ovqhypt	190	3	self	self	NN
cord-262253-3ovqhypt	190	4	-	-	HYPH
cord-262253-3ovqhypt	190	5	complimentary	complimentary	JJ
cord-262253-3ovqhypt	190	6	peptide	peptide	NN
cord-262253-3ovqhypt	190	7	containing	contain	VBG
cord-262253-3ovqhypt	190	8	two	two	CD
cord-262253-3ovqhypt	190	9	distinct	distinct	JJ
cord-262253-3ovqhypt	190	10	hydrophobic	hydrophobic	JJ
cord-262253-3ovqhypt	190	11	and	and	CC
cord-262253-3ovqhypt	190	12	hydrophilic	hydrophilic	JJ
cord-262253-3ovqhypt	190	13	surfaces	surface	NNS
cord-262253-3ovqhypt	190	14	,	,	,
cord-262253-3ovqhypt	190	15	Aβ	Aβ	NNP
cord-262253-3ovqhypt	190	16	peptides	peptide	NNS
cord-262253-3ovqhypt	190	17	can	can	MD
cord-262253-3ovqhypt	190	18	self	self	NN
cord-262253-3ovqhypt	190	19	-	-	HYPH
cord-262253-3ovqhypt	190	20	assemble	assemble	VB
cord-262253-3ovqhypt	190	21	into	into	IN
cord-262253-3ovqhypt	190	22	oligomers	oligomer	NNS
cord-262253-3ovqhypt	190	23	.	.	.
cord-262253-3ovqhypt	191	1	As	as	IN
cord-262253-3ovqhypt	191	2	oligomerization	oligomerization	NN
cord-262253-3ovqhypt	191	3	continues	continue	VBZ
cord-262253-3ovqhypt	191	4	,	,	,
cord-262253-3ovqhypt	191	5	a	a	DT
cord-262253-3ovqhypt	191	6	fibril	fibril	NNP
cord-262253-3ovqhypt	191	7	network	network	NN
cord-262253-3ovqhypt	191	8	is	be	VBZ
cord-262253-3ovqhypt	191	9	created	create	VBN
cord-262253-3ovqhypt	191	10	which	which	WDT
cord-262253-3ovqhypt	191	11	targets	target	NNS
cord-262253-3ovqhypt	191	12	,	,	,
cord-262253-3ovqhypt	191	13	captures	capture	VBZ
cord-262253-3ovqhypt	191	14	and	and	CC
cord-262253-3ovqhypt	191	15	agglutinates	agglutinate	NNS
cord-262253-3ovqhypt	191	16	microbes	microbe	NNS
cord-262253-3ovqhypt	191	17	,	,	,
cord-262253-3ovqhypt	191	18	limiting	limit	VBG
cord-262253-3ovqhypt	191	19	their	-PRON-	PRP$
cord-262253-3ovqhypt	191	20	proliferation	proliferation	NN
cord-262253-3ovqhypt	191	21	and	and	CC
cord-262253-3ovqhypt	191	22	impact	impact	NN
cord-262253-3ovqhypt	191	23	on	on	IN
cord-262253-3ovqhypt	191	24	their	-PRON-	PRP$
cord-262253-3ovqhypt	191	25	environment	environment	NN
cord-262253-3ovqhypt	191	26	.	.	.
cord-262253-3ovqhypt	192	1	Aβ	aβ	NN
cord-262253-3ovqhypt	192	2	peptide	peptide	JJ
cord-262253-3ovqhypt	192	3	affinity	affinity	NN
cord-262253-3ovqhypt	192	4	towards	towards	IN
cord-262253-3ovqhypt	192	5	microbes	microbe	NNS
cord-262253-3ovqhypt	192	6	has	have	VBZ
cord-262253-3ovqhypt	192	7	been	be	VBN
cord-262253-3ovqhypt	192	8	suggested	suggest	VBN
cord-262253-3ovqhypt	192	9	to	to	TO
cord-262253-3ovqhypt	192	10	be	be	VB
cord-262253-3ovqhypt	192	11	due	due	JJ
cord-262253-3ovqhypt	192	12	to	to	IN
cord-262253-3ovqhypt	192	13	its	-PRON-	PRP$
cord-262253-3ovqhypt	192	14	positive	positive	JJ
cord-262253-3ovqhypt	192	15	charge	charge	NN
cord-262253-3ovqhypt	192	16	and	and	CC
cord-262253-3ovqhypt	192	17	the	the	DT
cord-262253-3ovqhypt	192	18	microbe	microbe	NN
cord-262253-3ovqhypt	192	19	's	be	VBZ
cord-262253-3ovqhypt	192	20	negatively	negatively	RB
cord-262253-3ovqhypt	192	21	charged	charge	VBN
cord-262253-3ovqhypt	192	22	membrane	membrane	NN
cord-262253-3ovqhypt	192	23	[	[	-LRB-
cord-262253-3ovqhypt	192	24	30	30	CD
cord-262253-3ovqhypt	192	25	,	,	,
cord-262253-3ovqhypt	192	26	108	108	CD
cord-262253-3ovqhypt	192	27	,	,	,
cord-262253-3ovqhypt	192	28	109	109	CD
cord-262253-3ovqhypt	192	29	]	]	-RRB-
cord-262253-3ovqhypt	192	30	.	.	.
cord-262253-3ovqhypt	193	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	193	2	,	,	,
cord-262253-3ovqhypt	193	3	the	the	DT
cord-262253-3ovqhypt	193	4	ability	ability	NN
cord-262253-3ovqhypt	193	5	of	of	IN
cord-262253-3ovqhypt	193	6	Aβ	Aβ	NNP
cord-262253-3ovqhypt	193	7	peptides	peptide	NNS
cord-262253-3ovqhypt	193	8	to	to	TO
cord-262253-3ovqhypt	193	9	agglutinate	agglutinate	VB
cord-262253-3ovqhypt	193	10	microbes	microbe	NNS
cord-262253-3ovqhypt	193	11	stems	stem	NNS
cord-262253-3ovqhypt	193	12	from	from	IN
cord-262253-3ovqhypt	193	13	its	-PRON-	PRP$
cord-262253-3ovqhypt	193	14	heparin	heparin	NN
cord-262253-3ovqhypt	193	15	-	-	HYPH
cord-262253-3ovqhypt	193	16	binding	bind	VBG
cord-262253-3ovqhypt	193	17	activity	activity	NN
cord-262253-3ovqhypt	193	18	,	,	,
cord-262253-3ovqhypt	193	19	which	which	WDT
cord-262253-3ovqhypt	193	20	is	be	VBZ
cord-262253-3ovqhypt	193	21	able	able	JJ
cord-262253-3ovqhypt	193	22	to	to	TO
cord-262253-3ovqhypt	193	23	target	target	VB
cord-262253-3ovqhypt	193	24	carbohydrates	carbohydrate	NNS
cord-262253-3ovqhypt	193	25	present	present	JJ
cord-262253-3ovqhypt	193	26	on	on	IN
cord-262253-3ovqhypt	193	27	the	the	DT
cord-262253-3ovqhypt	193	28	surface	surface	NN
cord-262253-3ovqhypt	193	29	of	of	IN
cord-262253-3ovqhypt	193	30	microbes	microbe	NNS
cord-262253-3ovqhypt	193	31	.	.	.
cord-262253-3ovqhypt	194	1	Once	once	RB
cord-262253-3ovqhypt	194	2	entrapped	entrap	VBN
cord-262253-3ovqhypt	194	3	,	,	,
cord-262253-3ovqhypt	194	4	it	-PRON-	PRP
cord-262253-3ovqhypt	194	5	is	be	VBZ
cord-262253-3ovqhypt	194	6	suggested	suggest	VBN
cord-262253-3ovqhypt	194	7	that	that	IN
cord-262253-3ovqhypt	194	8	Aβ	Aβ	NNP
cord-262253-3ovqhypt	194	9	peptides	peptide	NNS
cord-262253-3ovqhypt	194	10	induce	induce	VBP
cord-262253-3ovqhypt	194	11	cell	cell	NN
cord-262253-3ovqhypt	194	12	membrane	membrane	NN
cord-262253-3ovqhypt	194	13	disruption	disruption	NN
cord-262253-3ovqhypt	194	14	by	by	IN
cord-262253-3ovqhypt	194	15	forming	form	VBG
cord-262253-3ovqhypt	194	16	cation	cation	NN
cord-262253-3ovqhypt	194	17	channels	channel	NNS
cord-262253-3ovqhypt	194	18	.	.	.
cord-262253-3ovqhypt	195	1	These	these	DT
cord-262253-3ovqhypt	195	2	channels	channel	NNS
cord-262253-3ovqhypt	195	3	cause	cause	VBP
cord-262253-3ovqhypt	195	4	ion	ion	NN
cord-262253-3ovqhypt	195	5	dyshomeostasis	dyshomeostasis	NN
cord-262253-3ovqhypt	195	6	and	and	CC
cord-262253-3ovqhypt	195	7	subsequent	subsequent	JJ
cord-262253-3ovqhypt	195	8	cell	cell	NN
cord-262253-3ovqhypt	195	9	death	death	NN
cord-262253-3ovqhypt	195	10	.	.	.
cord-262253-3ovqhypt	196	1	This	this	DT
cord-262253-3ovqhypt	196	2	mechanism	mechanism	NN
cord-262253-3ovqhypt	196	3	is	be	VBZ
cord-262253-3ovqhypt	196	4	similar	similar	JJ
cord-262253-3ovqhypt	196	5	to	to	IN
cord-262253-3ovqhypt	196	6	the	the	DT
cord-262253-3ovqhypt	196	7	activity	activity	NN
cord-262253-3ovqhypt	196	8	observed	observe	VBN
cord-262253-3ovqhypt	196	9	in	in	IN
cord-262253-3ovqhypt	196	10	AMPs	amp	NNS
cord-262253-3ovqhypt	196	11	such	such	JJ
cord-262253-3ovqhypt	196	12	as	as	IN
cord-262253-3ovqhypt	196	13	LL-37	LL-37	NNP
cord-262253-3ovqhypt	196	14	,	,	,
cord-262253-3ovqhypt	196	15	which	which	WDT
cord-262253-3ovqhypt	196	16	assert	assert	VBP
cord-262253-3ovqhypt	196	17	protection	protection	NN
cord-262253-3ovqhypt	196	18	through	through	IN
cord-262253-3ovqhypt	196	19	microbial	microbial	JJ
cord-262253-3ovqhypt	196	20	agglutination	agglutination	NN
cord-262253-3ovqhypt	196	21	and	and	CC
cord-262253-3ovqhypt	196	22	entrapment	entrapment	NN
cord-262253-3ovqhypt	196	23	.	.	.
cord-262253-3ovqhypt	197	1	The	the	DT
cord-262253-3ovqhypt	197	2	oligomerization	oligomerization	NN
cord-262253-3ovqhypt	197	3	activity	activity	NN
cord-262253-3ovqhypt	197	4	observed	observe	VBN
cord-262253-3ovqhypt	197	5	with	with	IN
cord-262253-3ovqhypt	197	6	Aβ	Aβ	NNP
cord-262253-3ovqhypt	197	7	peptides	peptide	NNS
cord-262253-3ovqhypt	197	8	is	be	VBZ
cord-262253-3ovqhypt	197	9	a	a	DT
cord-262253-3ovqhypt	197	10	common	common	JJ
cord-262253-3ovqhypt	197	11	trait	trait	NN
cord-262253-3ovqhypt	197	12	of	of	IN
cord-262253-3ovqhypt	197	13	AMPs	amp	NNS
cord-262253-3ovqhypt	197	14	,	,	,
cord-262253-3ovqhypt	197	15	which	which	WDT
cord-262253-3ovqhypt	197	16	mediates	mediate	VBZ
cord-262253-3ovqhypt	197	17	their	-PRON-	PRP$
cord-262253-3ovqhypt	197	18	ability	ability	NN
cord-262253-3ovqhypt	197	19	to	to	TO
cord-262253-3ovqhypt	197	20	entrap	entrap	VB
cord-262253-3ovqhypt	197	21	and	and	CC
cord-262253-3ovqhypt	197	22	lyse	lyse	VB
cord-262253-3ovqhypt	197	23	pathogens	pathogen	NNS
cord-262253-3ovqhypt	197	24	while	while	IN
cord-262253-3ovqhypt	197	25	maintaining	maintain	VBG
cord-262253-3ovqhypt	197	26	their	-PRON-	PRP$
cord-262253-3ovqhypt	197	27	resistance	resistance	NN
cord-262253-3ovqhypt	197	28	to	to	IN
cord-262253-3ovqhypt	197	29	protease	protease	NN
cord-262253-3ovqhypt	197	30	activity	activity	NN
cord-262253-3ovqhypt	197	31	.	.	.
cord-262253-3ovqhypt	198	1	The	the	DT
cord-262253-3ovqhypt	198	2	entrapment	entrapment	NN
cord-262253-3ovqhypt	198	3	of	of	IN
cord-262253-3ovqhypt	198	4	microbes	microbe	NNS
cord-262253-3ovqhypt	198	5	and	and	CC
cord-262253-3ovqhypt	198	6	viruses	virus	NNS
cord-262253-3ovqhypt	198	7	can	can	MD
cord-262253-3ovqhypt	198	8	also	also	RB
cord-262253-3ovqhypt	198	9	enhance	enhance	VB
cord-262253-3ovqhypt	198	10	their	-PRON-	PRP$
cord-262253-3ovqhypt	198	11	uptake	uptake	NN
cord-262253-3ovqhypt	198	12	by	by	IN
cord-262253-3ovqhypt	198	13	neutrophils	neutrophil	NNS
cord-262253-3ovqhypt	198	14	and	and	CC
cord-262253-3ovqhypt	198	15	macrophages	macrophage	NNS
cord-262253-3ovqhypt	198	16	.	.	.
cord-262253-3ovqhypt	199	1	In	in	IN
cord-262253-3ovqhypt	199	2	respect	respect	NN
cord-262253-3ovqhypt	199	3	to	to	IN
cord-262253-3ovqhypt	199	4	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	199	5	,	,	,
cord-262253-3ovqhypt	199	6	Aβ	Aβ	NNP
cord-262253-3ovqhypt	199	7	peptides	peptide	NNS
cord-262253-3ovqhypt	199	8	have	have	VBP
cord-262253-3ovqhypt	199	9	been	be	VBN
cord-262253-3ovqhypt	199	10	proposed	propose	VBN
cord-262253-3ovqhypt	199	11	to	to	TO
cord-262253-3ovqhypt	199	12	interfere	interfere	VB
cord-262253-3ovqhypt	199	13	with	with	IN
cord-262253-3ovqhypt	199	14	its	-PRON-	PRP$
cord-262253-3ovqhypt	199	15	ability	ability	NN
cord-262253-3ovqhypt	199	16	to	to	TO
cord-262253-3ovqhypt	199	17	fuse	fuse	VB
cord-262253-3ovqhypt	199	18	with	with	IN
cord-262253-3ovqhypt	199	19	the	the	DT
cord-262253-3ovqhypt	199	20	plasma	plasma	NN
cord-262253-3ovqhypt	199	21	membrane	membrane	NN
cord-262253-3ovqhypt	199	22	of	of	IN
cord-262253-3ovqhypt	199	23	cells	cell	NNS
cord-262253-3ovqhypt	199	24	,	,	,
cord-262253-3ovqhypt	199	25	hindering	hinder	VBG
cord-262253-3ovqhypt	199	26	its	-PRON-	PRP$
cord-262253-3ovqhypt	199	27	infective	infective	JJ
cord-262253-3ovqhypt	199	28	ability	ability	NN
cord-262253-3ovqhypt	199	29	[	[	-LRB-
cord-262253-3ovqhypt	199	30	110	110	CD
cord-262253-3ovqhypt	199	31	]	]	-RRB-
cord-262253-3ovqhypt	199	32	.	.	.
cord-262253-3ovqhypt	200	1	Int	Int	NNP
cord-262253-3ovqhypt	200	2	.	.	NNP
cord-262253-3ovqhypt	200	3	J.	J.	NNP
cord-262253-3ovqhypt	200	4	Mol	Mol	NNP
cord-262253-3ovqhypt	200	5	.	.	.
cord-262253-3ovqhypt	201	1	Sci	Sci	NNP
cord-262253-3ovqhypt	201	2	.	.	.
cord-262253-3ovqhypt	202	1	2020	2020	CD
cord-262253-3ovqhypt	202	2	,	,	,
cord-262253-3ovqhypt	202	3	21	21	CD
cord-262253-3ovqhypt	202	4	,	,	,
cord-262253-3ovqhypt	202	5	x	x	NN
cord-262253-3ovqhypt	202	6	FOR	for	IN
cord-262253-3ovqhypt	202	7	PEER	PEER	NNP
cord-262253-3ovqhypt	202	8	REVIEW	REVIEW	NNP
cord-262253-3ovqhypt	202	9	8	8	CD
cord-262253-3ovqhypt	202	10	of	of	IN
cord-262253-3ovqhypt	202	11	20	20	CD
cord-262253-3ovqhypt	202	12	 	 	_SP
cord-262253-3ovqhypt	203	1	In	in	IN
cord-262253-3ovqhypt	203	2	aligning	align	VBG
cord-262253-3ovqhypt	203	3	with	with	IN
cord-262253-3ovqhypt	203	4	the	the	DT
cord-262253-3ovqhypt	203	5	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	203	6	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	203	7	of	of	IN
cord-262253-3ovqhypt	203	8	AD	ad	NN
cord-262253-3ovqhypt	203	9	,	,	,
cord-262253-3ovqhypt	203	10	the	the	DT
cord-262253-3ovqhypt	203	11	use	use	NN
cord-262253-3ovqhypt	203	12	of	of	IN
cord-262253-3ovqhypt	203	13	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	203	14	and	and	CC
cord-262253-3ovqhypt	203	15	antiviral	antiviral	JJ
cord-262253-3ovqhypt	203	16	therapeutics	therapeutic	NNS
cord-262253-3ovqhypt	203	17	could	could	MD
cord-262253-3ovqhypt	203	18	prove	prove	VB
cord-262253-3ovqhypt	203	19	to	to	TO
cord-262253-3ovqhypt	203	20	be	be	VB
cord-262253-3ovqhypt	203	21	effective	effective	JJ
cord-262253-3ovqhypt	203	22	in	in	IN
cord-262253-3ovqhypt	203	23	targeting	target	VBG
cord-262253-3ovqhypt	203	24	the	the	DT
cord-262253-3ovqhypt	203	25	root	root	NN
cord-262253-3ovqhypt	203	26	cause	cause	NN
cord-262253-3ovqhypt	203	27	of	of	IN
cord-262253-3ovqhypt	203	28	AD	ad	NN
cord-262253-3ovqhypt	203	29	.	.	.
cord-262253-3ovqhypt	204	1	It	-PRON-	PRP
cord-262253-3ovqhypt	204	2	should	should	MD
cord-262253-3ovqhypt	204	3	be	be	VB
cord-262253-3ovqhypt	204	4	noted	note	VBN
cord-262253-3ovqhypt	204	5	,	,	,
cord-262253-3ovqhypt	204	6	however	however	RB
cord-262253-3ovqhypt	204	7	,	,	,
cord-262253-3ovqhypt	204	8	that	that	IN
cord-262253-3ovqhypt	204	9	the	the	DT
cord-262253-3ovqhypt	204	10	chronic	chronic	NN
cord-262253-3ovqhypt	204	11	over	over	IN
cord-262253-3ovqhypt	204	12	-	-	HYPH
cord-262253-3ovqhypt	204	13	production	production	NN
cord-262253-3ovqhypt	204	14	of	of	IN
cord-262253-3ovqhypt	204	15	Aβ	Aβ	NNP
cord-262253-3ovqhypt	204	16	peptides	peptide	NNS
cord-262253-3ovqhypt	204	17	,	,	,
cord-262253-3ovqhypt	204	18	which	which	WDT
cord-262253-3ovqhypt	204	19	form	form	VBP
cord-262253-3ovqhypt	204	20	numerous	numerous	JJ
cord-262253-3ovqhypt	204	21	insoluble	insoluble	JJ
cord-262253-3ovqhypt	204	22	plaques	plaque	NNS
cord-262253-3ovqhypt	204	23	,	,	,
cord-262253-3ovqhypt	204	24	would	would	MD
cord-262253-3ovqhypt	204	25	also	also	RB
cord-262253-3ovqhypt	204	26	need	need	VB
cord-262253-3ovqhypt	204	27	to	to	TO
cord-262253-3ovqhypt	204	28	be	be	VB
cord-262253-3ovqhypt	204	29	addressed	address	VBN
cord-262253-3ovqhypt	204	30	.	.	.
cord-262253-3ovqhypt	205	1	As	as	IN
cord-262253-3ovqhypt	205	2	such	such	JJ
cord-262253-3ovqhypt	205	3	,	,	,
cord-262253-3ovqhypt	205	4	the	the	DT
cord-262253-3ovqhypt	205	5	primary	primary	JJ
cord-262253-3ovqhypt	205	6	aim	aim	NN
cord-262253-3ovqhypt	205	7	of	of	IN
cord-262253-3ovqhypt	205	8	these	these	DT
cord-262253-3ovqhypt	205	9	drugs	drug	NNS
cord-262253-3ovqhypt	205	10	would	would	MD
cord-262253-3ovqhypt	205	11	be	be	VB
cord-262253-3ovqhypt	205	12	to	to	TO
cord-262253-3ovqhypt	205	13	target	target	VB
cord-262253-3ovqhypt	205	14	bacteria	bacteria	NNS
cord-262253-3ovqhypt	205	15	and	and	CC
cord-262253-3ovqhypt	205	16	viruses	virus	NNS
cord-262253-3ovqhypt	205	17	,	,	,
cord-262253-3ovqhypt	205	18	but	but	CC
cord-262253-3ovqhypt	205	19	a	a	DT
cord-262253-3ovqhypt	205	20	secondary	secondary	JJ
cord-262253-3ovqhypt	205	21	aim	aim	NN
cord-262253-3ovqhypt	205	22	would	would	MD
cord-262253-3ovqhypt	205	23	be	be	VB
cord-262253-3ovqhypt	205	24	to	to	TO
cord-262253-3ovqhypt	205	25	reduce	reduce	VB
cord-262253-3ovqhypt	205	26	the	the	DT
cord-262253-3ovqhypt	205	27	already	already	RB
cord-262253-3ovqhypt	205	28	-	-	HYPH
cord-262253-3ovqhypt	205	29	present	present	JJ
cord-262253-3ovqhypt	205	30	Aβ	Aβ	NNP
cord-262253-3ovqhypt	205	31	burden	burden	NN
cord-262253-3ovqhypt	205	32	that	that	IN
cord-262253-3ovqhypt	205	33	the	the	DT
cord-262253-3ovqhypt	205	34	brain	brain	NN
cord-262253-3ovqhypt	205	35	is	be	VBZ
cord-262253-3ovqhypt	205	36	under	under	IN
cord-262253-3ovqhypt	205	37	.	.	.
cord-262253-3ovqhypt	206	1	Acyclovir	Acyclovir	NNP
cord-262253-3ovqhypt	206	2	is	be	VBZ
cord-262253-3ovqhypt	206	3	an	an	DT
cord-262253-3ovqhypt	206	4	antiviral	antiviral	JJ
cord-262253-3ovqhypt	206	5	drug	drug	NN
cord-262253-3ovqhypt	206	6	that	that	WDT
cord-262253-3ovqhypt	206	7	is	be	VBZ
cord-262253-3ovqhypt	206	8	used	use	VBN
cord-262253-3ovqhypt	206	9	for	for	IN
cord-262253-3ovqhypt	206	10	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	206	11	infections	infection	NNS
cord-262253-3ovqhypt	206	12	,	,	,
cord-262253-3ovqhypt	206	13	which	which	WDT
cord-262253-3ovqhypt	206	14	has	have	VBZ
cord-262253-3ovqhypt	206	15	been	be	VBN
cord-262253-3ovqhypt	206	16	found	find	VBN
cord-262253-3ovqhypt	206	17	to	to	TO
cord-262253-3ovqhypt	206	18	be	be	VB
cord-262253-3ovqhypt	206	19	well	well	RB
cord-262253-3ovqhypt	206	20	tolerated	tolerate	VBN
cord-262253-3ovqhypt	206	21	and	and	CC
cord-262253-3ovqhypt	206	22	safe	safe	JJ
cord-262253-3ovqhypt	206	23	[	[	-LRB-
cord-262253-3ovqhypt	206	24	111	111	CD
cord-262253-3ovqhypt	206	25	]	]	-RRB-
cord-262253-3ovqhypt	206	26	.	.	.
cord-262253-3ovqhypt	207	1	By	by	IN
cord-262253-3ovqhypt	207	2	inhibiting	inhibit	VBG
cord-262253-3ovqhypt	207	3	the	the	DT
cord-262253-3ovqhypt	207	4	virus	virus	NN
cord-262253-3ovqhypt	207	5	's	's	POS
cord-262253-3ovqhypt	207	6	replication	replication	NN
cord-262253-3ovqhypt	207	7	,	,	,
cord-262253-3ovqhypt	207	8	this	this	DT
cord-262253-3ovqhypt	207	9	antiviral	antiviral	JJ
cord-262253-3ovqhypt	207	10	agent	agent	NN
cord-262253-3ovqhypt	207	11	is	be	VBZ
cord-262253-3ovqhypt	207	12	able	able	JJ
cord-262253-3ovqhypt	207	13	to	to	TO
cord-262253-3ovqhypt	207	14	reduce	reduce	VB
cord-262253-3ovqhypt	207	15	the	the	DT
cord-262253-3ovqhypt	207	16	viral	viral	JJ
cord-262253-3ovqhypt	207	17	load	load	NN
cord-262253-3ovqhypt	207	18	exhibited	exhibit	VBN
cord-262253-3ovqhypt	207	19	by	by	IN
cord-262253-3ovqhypt	207	20	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	207	21	.	.	.
cord-262253-3ovqhypt	208	1	Administration	Administration	NNP
cord-262253-3ovqhypt	208	2	of	of	IN
cord-262253-3ovqhypt	208	3	acyclovir	acyclovir	NNP
cord-262253-3ovqhypt	208	4	in	in	IN
cord-262253-3ovqhypt	208	5	HSV-1-infected	hsv-1-infecte	VBN
cord-262253-3ovqhypt	208	6	cells	cell	NNS
cord-262253-3ovqhypt	208	7	has	have	VBZ
cord-262253-3ovqhypt	208	8	been	be	VBN
cord-262253-3ovqhypt	208	9	found	find	VBN
cord-262253-3ovqhypt	208	10	to	to	TO
cord-262253-3ovqhypt	208	11	cause	cause	VB
cord-262253-3ovqhypt	208	12	a	a	DT
cord-262253-3ovqhypt	208	13	significant	significant	JJ
cord-262253-3ovqhypt	208	14	reduction	reduction	NN
cord-262253-3ovqhypt	208	15	of	of	IN
cord-262253-3ovqhypt	208	16	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	208	17	proteins	protein	NNS
cord-262253-3ovqhypt	208	18	,	,	,
cord-262253-3ovqhypt	208	19	along	along	IN
cord-262253-3ovqhypt	208	20	with	with	IN
cord-262253-3ovqhypt	208	21	a	a	DT
cord-262253-3ovqhypt	208	22	reduction	reduction	NN
cord-262253-3ovqhypt	208	23	of	of	IN
cord-262253-3ovqhypt	208	24	roughly	roughly	RB
cord-262253-3ovqhypt	208	25	28	28	CD
cord-262253-3ovqhypt	208	26	%	%	NN
cord-262253-3ovqhypt	208	27	in	in	IN
cord-262253-3ovqhypt	208	28	Aβ	Aβ	NNP
cord-262253-3ovqhypt	208	29	accumulation	accumulation	NN
cord-262253-3ovqhypt	208	30	,	,	,
cord-262253-3ovqhypt	208	31	compared	compare	VBN
cord-262253-3ovqhypt	208	32	to	to	IN
cord-262253-3ovqhypt	208	33	untreated	untreated	JJ
cord-262253-3ovqhypt	208	34	cells	cell	NNS
cord-262253-3ovqhypt	208	35	.	.	.
cord-262253-3ovqhypt	209	1	The	the	DT
cord-262253-3ovqhypt	209	2	study	study	NN
cord-262253-3ovqhypt	209	3	associated	associate	VBD
cord-262253-3ovqhypt	209	4	this	this	DT
cord-262253-3ovqhypt	209	5	with	with	IN
cord-262253-3ovqhypt	209	6	reduced	reduced	JJ
cord-262253-3ovqhypt	209	7	levels	level	NNS
cord-262253-3ovqhypt	209	8	of	of	IN
cord-262253-3ovqhypt	209	9	βsecretase	βsecretase	NNP
cord-262253-3ovqhypt	209	10	and	and	CC
cord-262253-3ovqhypt	209	11	a	a	DT
cord-262253-3ovqhypt	209	12	component	component	NN
cord-262253-3ovqhypt	209	13	of	of	IN
cord-262253-3ovqhypt	209	14	γ	γ	NNP
cord-262253-3ovqhypt	209	15	-	-	HYPH
cord-262253-3ovqhypt	209	16	secretase	secretase	NNP
cord-262253-3ovqhypt	209	17	which	which	WDT
cord-262253-3ovqhypt	209	18	metabolizes	metabolize	VBZ
cord-262253-3ovqhypt	209	19	APP	app	NN
cord-262253-3ovqhypt	209	20	into	into	IN
cord-262253-3ovqhypt	209	21	Aβ	Aβ	NNP
cord-262253-3ovqhypt	209	22	[	[	-LRB-
cord-262253-3ovqhypt	209	23	112	112	CD
cord-262253-3ovqhypt	209	24	]	]	-RRB-
cord-262253-3ovqhypt	209	25	.	.	.
cord-262253-3ovqhypt	210	1	Acyclovir	Acyclovir	NNP
cord-262253-3ovqhypt	210	2	administration	administration	NN
cord-262253-3ovqhypt	210	3	has	have	VBZ
cord-262253-3ovqhypt	210	4	also	also	RB
cord-262253-3ovqhypt	210	5	shown	show	VBN
cord-262253-3ovqhypt	210	6	to	to	TO
cord-262253-3ovqhypt	210	7	prevent	prevent	VB
cord-262253-3ovqhypt	210	8	HSV-1-related	hsv-1-relate	VBN
cord-262253-3ovqhypt	210	9	neuronal	neuronal	JJ
cord-262253-3ovqhypt	210	10	death	death	NN
cord-262253-3ovqhypt	210	11	[	[	-LRB-
cord-262253-3ovqhypt	210	12	113	113	CD
cord-262253-3ovqhypt	210	13	]	]	-RRB-
cord-262253-3ovqhypt	210	14	.	.	.
cord-262253-3ovqhypt	211	1	In	in	IN
cord-262253-3ovqhypt	211	2	relation	relation	NN
cord-262253-3ovqhypt	211	3	to	to	IN
cord-262253-3ovqhypt	211	4	the	the	DT
cord-262253-3ovqhypt	211	5	cognitive	cognitive	JJ
cord-262253-3ovqhypt	211	6	impairment	impairment	NN
cord-262253-3ovqhypt	211	7	observed	observe	VBN
cord-262253-3ovqhypt	211	8	in	in	IN
cord-262253-3ovqhypt	211	9	AD	AD	NNP
cord-262253-3ovqhypt	211	10	,	,	,
cord-262253-3ovqhypt	211	11	a	a	DT
cord-262253-3ovqhypt	211	12	study	study	NN
cord-262253-3ovqhypt	211	13	by	by	IN
cord-262253-3ovqhypt	211	14	Hui	Hui	NNP
cord-262253-3ovqhypt	211	15	et	et	NNP
cord-262253-3ovqhypt	211	16	al	al	NNP
cord-262253-3ovqhypt	211	17	.	.	NNP
cord-262253-3ovqhypt	211	18	investigated	investigate	VBD
cord-262253-3ovqhypt	211	19	the	the	DT
cord-262253-3ovqhypt	211	20	effects	effect	NNS
cord-262253-3ovqhypt	211	21	of	of	IN
cord-262253-3ovqhypt	211	22	acyclovir	acyclovir	NN
cord-262253-3ovqhypt	211	23	on	on	IN
cord-262253-3ovqhypt	211	24	Aβ	Aβ	NNP
cord-262253-3ovqhypt	211	25	oligomer	oligomer	NNP
cord-262253-3ovqhypt	211	26	-	-	HYPH
cord-262253-3ovqhypt	211	27	induced	induce	VBN
cord-262253-3ovqhypt	211	28	spatial	spatial	JJ
cord-262253-3ovqhypt	211	29	cognitive	cognitive	JJ
cord-262253-3ovqhypt	211	30	impairments	impairment	NNS
cord-262253-3ovqhypt	211	31	.	.	.
cord-262253-3ovqhypt	212	1	The	the	DT
cord-262253-3ovqhypt	212	2	study	study	NN
cord-262253-3ovqhypt	212	3	found	find	VBD
cord-262253-3ovqhypt	212	4	that	that	IN
cord-262253-3ovqhypt	212	5	the	the	DT
cord-262253-3ovqhypt	212	6	co	co	NN
cord-262253-3ovqhypt	212	7	-	-	NN
cord-262253-3ovqhypt	212	8	administration	administration	NN
cord-262253-3ovqhypt	212	9	of	of	IN
cord-262253-3ovqhypt	212	10	 	 	_SP
cord-262253-3ovqhypt	212	11	In	in	IN
cord-262253-3ovqhypt	212	12	aligning	align	VBG
cord-262253-3ovqhypt	212	13	with	with	IN
cord-262253-3ovqhypt	212	14	the	the	DT
cord-262253-3ovqhypt	212	15	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	212	16	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	212	17	of	of	IN
cord-262253-3ovqhypt	212	18	AD	ad	NN
cord-262253-3ovqhypt	212	19	,	,	,
cord-262253-3ovqhypt	212	20	the	the	DT
cord-262253-3ovqhypt	212	21	use	use	NN
cord-262253-3ovqhypt	212	22	of	of	IN
cord-262253-3ovqhypt	212	23	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	212	24	and	and	CC
cord-262253-3ovqhypt	212	25	antiviral	antiviral	JJ
cord-262253-3ovqhypt	212	26	therapeutics	therapeutic	NNS
cord-262253-3ovqhypt	212	27	could	could	MD
cord-262253-3ovqhypt	212	28	prove	prove	VB
cord-262253-3ovqhypt	212	29	to	to	TO
cord-262253-3ovqhypt	212	30	be	be	VB
cord-262253-3ovqhypt	212	31	effective	effective	JJ
cord-262253-3ovqhypt	212	32	in	in	IN
cord-262253-3ovqhypt	212	33	targeting	target	VBG
cord-262253-3ovqhypt	212	34	the	the	DT
cord-262253-3ovqhypt	212	35	root	root	NN
cord-262253-3ovqhypt	212	36	cause	cause	NN
cord-262253-3ovqhypt	212	37	of	of	IN
cord-262253-3ovqhypt	212	38	AD	ad	NN
cord-262253-3ovqhypt	212	39	.	.	.
cord-262253-3ovqhypt	213	1	It	-PRON-	PRP
cord-262253-3ovqhypt	213	2	should	should	MD
cord-262253-3ovqhypt	213	3	be	be	VB
cord-262253-3ovqhypt	213	4	noted	note	VBN
cord-262253-3ovqhypt	213	5	,	,	,
cord-262253-3ovqhypt	213	6	however	however	RB
cord-262253-3ovqhypt	213	7	,	,	,
cord-262253-3ovqhypt	213	8	that	that	IN
cord-262253-3ovqhypt	213	9	the	the	DT
cord-262253-3ovqhypt	213	10	chronic	chronic	NN
cord-262253-3ovqhypt	213	11	over	over	IN
cord-262253-3ovqhypt	213	12	-	-	HYPH
cord-262253-3ovqhypt	213	13	production	production	NN
cord-262253-3ovqhypt	213	14	of	of	IN
cord-262253-3ovqhypt	213	15	Aβ	Aβ	NNP
cord-262253-3ovqhypt	213	16	peptides	peptide	NNS
cord-262253-3ovqhypt	213	17	,	,	,
cord-262253-3ovqhypt	213	18	which	which	WDT
cord-262253-3ovqhypt	213	19	form	form	VBP
cord-262253-3ovqhypt	213	20	numerous	numerous	JJ
cord-262253-3ovqhypt	213	21	insoluble	insoluble	JJ
cord-262253-3ovqhypt	213	22	plaques	plaque	NNS
cord-262253-3ovqhypt	213	23	,	,	,
cord-262253-3ovqhypt	213	24	would	would	MD
cord-262253-3ovqhypt	213	25	also	also	RB
cord-262253-3ovqhypt	213	26	need	need	VB
cord-262253-3ovqhypt	213	27	to	to	TO
cord-262253-3ovqhypt	213	28	be	be	VB
cord-262253-3ovqhypt	213	29	addressed	address	VBN
cord-262253-3ovqhypt	213	30	.	.	.
cord-262253-3ovqhypt	214	1	As	as	IN
cord-262253-3ovqhypt	214	2	such	such	JJ
cord-262253-3ovqhypt	214	3	,	,	,
cord-262253-3ovqhypt	214	4	the	the	DT
cord-262253-3ovqhypt	214	5	primary	primary	JJ
cord-262253-3ovqhypt	214	6	aim	aim	NN
cord-262253-3ovqhypt	214	7	of	of	IN
cord-262253-3ovqhypt	214	8	these	these	DT
cord-262253-3ovqhypt	214	9	drugs	drug	NNS
cord-262253-3ovqhypt	214	10	would	would	MD
cord-262253-3ovqhypt	214	11	be	be	VB
cord-262253-3ovqhypt	214	12	to	to	TO
cord-262253-3ovqhypt	214	13	target	target	VB
cord-262253-3ovqhypt	214	14	bacteria	bacteria	NNS
cord-262253-3ovqhypt	214	15	and	and	CC
cord-262253-3ovqhypt	214	16	viruses	virus	NNS
cord-262253-3ovqhypt	214	17	,	,	,
cord-262253-3ovqhypt	214	18	but	but	CC
cord-262253-3ovqhypt	214	19	a	a	DT
cord-262253-3ovqhypt	214	20	secondary	secondary	JJ
cord-262253-3ovqhypt	214	21	aim	aim	NN
cord-262253-3ovqhypt	214	22	would	would	MD
cord-262253-3ovqhypt	214	23	be	be	VB
cord-262253-3ovqhypt	214	24	to	to	TO
cord-262253-3ovqhypt	214	25	reduce	reduce	VB
cord-262253-3ovqhypt	214	26	the	the	DT
cord-262253-3ovqhypt	214	27	already	already	RB
cord-262253-3ovqhypt	214	28	-	-	HYPH
cord-262253-3ovqhypt	214	29	present	present	JJ
cord-262253-3ovqhypt	214	30	Aβ	Aβ	NNP
cord-262253-3ovqhypt	214	31	burden	burden	NN
cord-262253-3ovqhypt	214	32	that	that	IN
cord-262253-3ovqhypt	214	33	the	the	DT
cord-262253-3ovqhypt	214	34	brain	brain	NN
cord-262253-3ovqhypt	214	35	is	be	VBZ
cord-262253-3ovqhypt	214	36	under	under	IN
cord-262253-3ovqhypt	214	37	.	.	.
cord-262253-3ovqhypt	215	1	Acyclovir	Acyclovir	NNP
cord-262253-3ovqhypt	215	2	is	be	VBZ
cord-262253-3ovqhypt	215	3	an	an	DT
cord-262253-3ovqhypt	215	4	antiviral	antiviral	JJ
cord-262253-3ovqhypt	215	5	drug	drug	NN
cord-262253-3ovqhypt	215	6	that	that	WDT
cord-262253-3ovqhypt	215	7	is	be	VBZ
cord-262253-3ovqhypt	215	8	used	use	VBN
cord-262253-3ovqhypt	215	9	for	for	IN
cord-262253-3ovqhypt	215	10	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	215	11	infections	infection	NNS
cord-262253-3ovqhypt	215	12	,	,	,
cord-262253-3ovqhypt	215	13	which	which	WDT
cord-262253-3ovqhypt	215	14	has	have	VBZ
cord-262253-3ovqhypt	215	15	been	be	VBN
cord-262253-3ovqhypt	215	16	found	find	VBN
cord-262253-3ovqhypt	215	17	to	to	TO
cord-262253-3ovqhypt	215	18	be	be	VB
cord-262253-3ovqhypt	215	19	well	well	RB
cord-262253-3ovqhypt	215	20	tolerated	tolerate	VBN
cord-262253-3ovqhypt	215	21	and	and	CC
cord-262253-3ovqhypt	215	22	safe	safe	JJ
cord-262253-3ovqhypt	215	23	[	[	-LRB-
cord-262253-3ovqhypt	215	24	111	111	CD
cord-262253-3ovqhypt	215	25	]	]	-RRB-
cord-262253-3ovqhypt	215	26	.	.	.
cord-262253-3ovqhypt	216	1	By	by	IN
cord-262253-3ovqhypt	216	2	inhibiting	inhibit	VBG
cord-262253-3ovqhypt	216	3	the	the	DT
cord-262253-3ovqhypt	216	4	virus	virus	NN
cord-262253-3ovqhypt	216	5	's	's	POS
cord-262253-3ovqhypt	216	6	replication	replication	NN
cord-262253-3ovqhypt	216	7	,	,	,
cord-262253-3ovqhypt	216	8	this	this	DT
cord-262253-3ovqhypt	216	9	antiviral	antiviral	JJ
cord-262253-3ovqhypt	216	10	agent	agent	NN
cord-262253-3ovqhypt	216	11	is	be	VBZ
cord-262253-3ovqhypt	216	12	able	able	JJ
cord-262253-3ovqhypt	216	13	to	to	TO
cord-262253-3ovqhypt	216	14	reduce	reduce	VB
cord-262253-3ovqhypt	216	15	the	the	DT
cord-262253-3ovqhypt	216	16	viral	viral	JJ
cord-262253-3ovqhypt	216	17	load	load	NN
cord-262253-3ovqhypt	216	18	exhibited	exhibit	VBN
cord-262253-3ovqhypt	216	19	by	by	IN
cord-262253-3ovqhypt	216	20	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	216	21	.	.	.
cord-262253-3ovqhypt	217	1	Administration	Administration	NNP
cord-262253-3ovqhypt	217	2	of	of	IN
cord-262253-3ovqhypt	217	3	acyclovir	acyclovir	NNP
cord-262253-3ovqhypt	217	4	in	in	IN
cord-262253-3ovqhypt	217	5	HSV-1-infected	hsv-1-infecte	VBN
cord-262253-3ovqhypt	217	6	cells	cell	NNS
cord-262253-3ovqhypt	217	7	has	have	VBZ
cord-262253-3ovqhypt	217	8	been	be	VBN
cord-262253-3ovqhypt	217	9	found	find	VBN
cord-262253-3ovqhypt	217	10	to	to	TO
cord-262253-3ovqhypt	217	11	cause	cause	VB
cord-262253-3ovqhypt	217	12	a	a	DT
cord-262253-3ovqhypt	217	13	significant	significant	JJ
cord-262253-3ovqhypt	217	14	reduction	reduction	NN
cord-262253-3ovqhypt	217	15	of	of	IN
cord-262253-3ovqhypt	217	16	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	217	17	proteins	protein	NNS
cord-262253-3ovqhypt	217	18	,	,	,
cord-262253-3ovqhypt	217	19	along	along	IN
cord-262253-3ovqhypt	217	20	with	with	IN
cord-262253-3ovqhypt	217	21	a	a	DT
cord-262253-3ovqhypt	217	22	reduction	reduction	NN
cord-262253-3ovqhypt	217	23	of	of	IN
cord-262253-3ovqhypt	217	24	roughly	roughly	RB
cord-262253-3ovqhypt	217	25	28	28	CD
cord-262253-3ovqhypt	217	26	%	%	NN
cord-262253-3ovqhypt	217	27	in	in	IN
cord-262253-3ovqhypt	217	28	Aβ	Aβ	NNP
cord-262253-3ovqhypt	217	29	accumulation	accumulation	NN
cord-262253-3ovqhypt	217	30	,	,	,
cord-262253-3ovqhypt	217	31	compared	compare	VBN
cord-262253-3ovqhypt	217	32	to	to	IN
cord-262253-3ovqhypt	217	33	untreated	untreated	JJ
cord-262253-3ovqhypt	217	34	cells	cell	NNS
cord-262253-3ovqhypt	217	35	.	.	.
cord-262253-3ovqhypt	218	1	The	the	DT
cord-262253-3ovqhypt	218	2	study	study	NN
cord-262253-3ovqhypt	218	3	associated	associate	VBD
cord-262253-3ovqhypt	218	4	this	this	DT
cord-262253-3ovqhypt	218	5	with	with	IN
cord-262253-3ovqhypt	218	6	reduced	reduced	JJ
cord-262253-3ovqhypt	218	7	levels	level	NNS
cord-262253-3ovqhypt	218	8	of	of	IN
cord-262253-3ovqhypt	218	9	β	β	NN
cord-262253-3ovqhypt	218	10	-	-	HYPH
cord-262253-3ovqhypt	218	11	secretase	secretase	NNP
cord-262253-3ovqhypt	218	12	and	and	CC
cord-262253-3ovqhypt	218	13	a	a	DT
cord-262253-3ovqhypt	218	14	component	component	NN
cord-262253-3ovqhypt	218	15	of	of	IN
cord-262253-3ovqhypt	218	16	γ	γ	NNP
cord-262253-3ovqhypt	218	17	-	-	HYPH
cord-262253-3ovqhypt	218	18	secretase	secretase	NNP
cord-262253-3ovqhypt	218	19	which	which	WDT
cord-262253-3ovqhypt	218	20	metabolizes	metabolize	VBZ
cord-262253-3ovqhypt	218	21	APP	app	NN
cord-262253-3ovqhypt	218	22	into	into	IN
cord-262253-3ovqhypt	218	23	Aβ	Aβ	NNP
cord-262253-3ovqhypt	218	24	[	[	-LRB-
cord-262253-3ovqhypt	218	25	112	112	CD
cord-262253-3ovqhypt	218	26	]	]	-RRB-
cord-262253-3ovqhypt	218	27	.	.	.
cord-262253-3ovqhypt	219	1	Acyclovir	Acyclovir	NNP
cord-262253-3ovqhypt	219	2	administration	administration	NN
cord-262253-3ovqhypt	219	3	has	have	VBZ
cord-262253-3ovqhypt	219	4	also	also	RB
cord-262253-3ovqhypt	219	5	shown	show	VBN
cord-262253-3ovqhypt	219	6	to	to	TO
cord-262253-3ovqhypt	219	7	prevent	prevent	VB
cord-262253-3ovqhypt	219	8	HSV-1-related	hsv-1-relate	VBN
cord-262253-3ovqhypt	219	9	neuronal	neuronal	JJ
cord-262253-3ovqhypt	219	10	death	death	NN
cord-262253-3ovqhypt	219	11	[	[	-LRB-
cord-262253-3ovqhypt	219	12	113	113	CD
cord-262253-3ovqhypt	219	13	]	]	-RRB-
cord-262253-3ovqhypt	219	14	.	.	.
cord-262253-3ovqhypt	220	1	In	in	IN
cord-262253-3ovqhypt	220	2	relation	relation	NN
cord-262253-3ovqhypt	220	3	to	to	IN
cord-262253-3ovqhypt	220	4	the	the	DT
cord-262253-3ovqhypt	220	5	cognitive	cognitive	JJ
cord-262253-3ovqhypt	220	6	impairment	impairment	NN
cord-262253-3ovqhypt	220	7	observed	observe	VBN
cord-262253-3ovqhypt	220	8	in	in	IN
cord-262253-3ovqhypt	220	9	AD	AD	NNP
cord-262253-3ovqhypt	220	10	,	,	,
cord-262253-3ovqhypt	220	11	a	a	DT
cord-262253-3ovqhypt	220	12	study	study	NN
cord-262253-3ovqhypt	220	13	by	by	IN
cord-262253-3ovqhypt	220	14	Hui	Hui	NNP
cord-262253-3ovqhypt	220	15	et	et	NNP
cord-262253-3ovqhypt	220	16	al	al	NNP
cord-262253-3ovqhypt	220	17	.	.	NNP
cord-262253-3ovqhypt	220	18	investigated	investigate	VBD
cord-262253-3ovqhypt	220	19	the	the	DT
cord-262253-3ovqhypt	220	20	effects	effect	NNS
cord-262253-3ovqhypt	220	21	of	of	IN
cord-262253-3ovqhypt	220	22	acyclovir	acyclovir	NN
cord-262253-3ovqhypt	220	23	on	on	IN
cord-262253-3ovqhypt	220	24	Aβ	Aβ	NNP
cord-262253-3ovqhypt	220	25	oligomer	oligomer	NNP
cord-262253-3ovqhypt	220	26	-	-	HYPH
cord-262253-3ovqhypt	220	27	induced	induce	VBN
cord-262253-3ovqhypt	220	28	spatial	spatial	JJ
cord-262253-3ovqhypt	220	29	cognitive	cognitive	JJ
cord-262253-3ovqhypt	220	30	impairments	impairment	NNS
cord-262253-3ovqhypt	220	31	.	.	.
cord-262253-3ovqhypt	221	1	The	the	DT
cord-262253-3ovqhypt	221	2	study	study	NN
cord-262253-3ovqhypt	221	3	found	find	VBD
cord-262253-3ovqhypt	221	4	that	that	IN
cord-262253-3ovqhypt	221	5	the	the	DT
cord-262253-3ovqhypt	221	6	co	co	NN
cord-262253-3ovqhypt	221	7	-	-	NN
cord-262253-3ovqhypt	221	8	administration	administration	NN
cord-262253-3ovqhypt	221	9	of	of	IN
cord-262253-3ovqhypt	221	10	acyclovir	acyclovir	NNP
cord-262253-3ovqhypt	221	11	with	with	IN
cord-262253-3ovqhypt	221	12	dexamethasone	dexamethasone	NN
cord-262253-3ovqhypt	221	13	attenuated	attenuate	VBN
cord-262253-3ovqhypt	221	14	impairments	impairment	NNS
cord-262253-3ovqhypt	221	15	in	in	IN
cord-262253-3ovqhypt	221	16	spatial	spatial	JJ
cord-262253-3ovqhypt	221	17	cognition	cognition	NN
cord-262253-3ovqhypt	221	18	.	.	.
cord-262253-3ovqhypt	222	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	222	2	,	,	,
cord-262253-3ovqhypt	222	3	this	this	DT
cord-262253-3ovqhypt	222	4	combination	combination	NN
cord-262253-3ovqhypt	222	5	reduced	reduce	VBD
cord-262253-3ovqhypt	222	6	the	the	DT
cord-262253-3ovqhypt	222	7	levels	level	NNS
cord-262253-3ovqhypt	222	8	of	of	IN
cord-262253-3ovqhypt	222	9	neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	222	10	markers	marker	NNS
cord-262253-3ovqhypt	222	11	such	such	JJ
cord-262253-3ovqhypt	222	12	as	as	IN
cord-262253-3ovqhypt	222	13	TNF	TNF	NNP
cord-262253-3ovqhypt	222	14	-	-	HYPH
cord-262253-3ovqhypt	222	15	α	α	NNP
cord-262253-3ovqhypt	222	16	and	and	CC
cord-262253-3ovqhypt	222	17	IL-6	IL-6	NNP
cord-262253-3ovqhypt	222	18	,	,	,
cord-262253-3ovqhypt	222	19	along	along	IN
cord-262253-3ovqhypt	222	20	with	with	IN
cord-262253-3ovqhypt	222	21	microglia	microglia	JJ
cord-262253-3ovqhypt	222	22	activation	activation	NN
cord-262253-3ovqhypt	222	23	.	.	.
cord-262253-3ovqhypt	223	1	Interestingly	interestingly	RB
cord-262253-3ovqhypt	223	2	,	,	,
cord-262253-3ovqhypt	223	3	the	the	DT
cord-262253-3ovqhypt	223	4	study	study	NN
cord-262253-3ovqhypt	223	5	found	find	VBD
cord-262253-3ovqhypt	223	6	these	these	DT
cord-262253-3ovqhypt	223	7	effects	effect	NNS
cord-262253-3ovqhypt	223	8	to	to	TO
cord-262253-3ovqhypt	223	9	only	only	RB
cord-262253-3ovqhypt	223	10	occur	occur	VB
cord-262253-3ovqhypt	223	11	when	when	WRB
cord-262253-3ovqhypt	223	12	acyclovir	acyclovir	NNP
cord-262253-3ovqhypt	223	13	and	and	CC
cord-262253-3ovqhypt	223	14	dexamethasone	dexamethasone	NN
cord-262253-3ovqhypt	223	15	were	be	VBD
cord-262253-3ovqhypt	223	16	administered	administer	VBN
cord-262253-3ovqhypt	223	17	together	together	RB
cord-262253-3ovqhypt	223	18	[	[	-LRB-
cord-262253-3ovqhypt	223	19	114	114	CD
cord-262253-3ovqhypt	223	20	]	]	-RRB-
cord-262253-3ovqhypt	223	21	.	.	.
cord-262253-3ovqhypt	224	1	Penciclovir	Penciclovir	NNP
cord-262253-3ovqhypt	224	2	is	be	VBZ
cord-262253-3ovqhypt	224	3	another	another	DT
cord-262253-3ovqhypt	224	4	antiviral	antiviral	JJ
cord-262253-3ovqhypt	224	5	drug	drug	NN
cord-262253-3ovqhypt	224	6	that	that	WDT
cord-262253-3ovqhypt	224	7	targets	target	VBZ
cord-262253-3ovqhypt	224	8	HSV-1	hsv-1	VBP
cord-262253-3ovqhypt	224	9	DNA	dna	NN
cord-262253-3ovqhypt	224	10	replication	replication	NN
cord-262253-3ovqhypt	224	11	by	by	IN
cord-262253-3ovqhypt	224	12	blocking	block	VBG
cord-262253-3ovqhypt	224	13	chain	chain	NN
cord-262253-3ovqhypt	224	14	elongation	elongation	NN
cord-262253-3ovqhypt	224	15	.	.	.
cord-262253-3ovqhypt	225	1	Cell	cell	NN
cord-262253-3ovqhypt	225	2	cultures	culture	NNS
cord-262253-3ovqhypt	225	3	infected	infect	VBN
cord-262253-3ovqhypt	225	4	with	with	IN
cord-262253-3ovqhypt	225	5	HSV-1	HSV-1	NNS
cord-262253-3ovqhypt	225	6	displayed	display	VBD
cord-262253-3ovqhypt	225	7	a	a	DT
cord-262253-3ovqhypt	225	8	reduction	reduction	NN
cord-262253-3ovqhypt	225	9	of	of	IN
cord-262253-3ovqhypt	225	10	virus	virus	NN
cord-262253-3ovqhypt	225	11	and	and	CC
cord-262253-3ovqhypt	225	12	Aβ	Aβ	NNP
cord-262253-3ovqhypt	225	13	accumulation	accumulation	NN
cord-262253-3ovqhypt	225	14	when	when	WRB
cord-262253-3ovqhypt	225	15	penciclovir	penciclovir	NNP
cord-262253-3ovqhypt	225	16	was	be	VBD
cord-262253-3ovqhypt	225	17	administered	administer	VBN
cord-262253-3ovqhypt	225	18	.	.	.
cord-262253-3ovqhypt	226	1	This	this	DT
cord-262253-3ovqhypt	226	2	was	be	VBD
cord-262253-3ovqhypt	226	3	paralleled	parallel	VBN
cord-262253-3ovqhypt	226	4	with	with	IN
cord-262253-3ovqhypt	226	5	a	a	DT
cord-262253-3ovqhypt	226	6	reduction	reduction	NN
cord-262253-3ovqhypt	226	7	in	in	IN
cord-262253-3ovqhypt	226	8	β	β	NNP
cord-262253-3ovqhypt	226	9	-	-	HYPH
cord-262253-3ovqhypt	226	10	secretase	secretase	NNP
cord-262253-3ovqhypt	226	11	and	and	CC
cord-262253-3ovqhypt	226	12	a	a	DT
cord-262253-3ovqhypt	226	13	component	component	NN
cord-262253-3ovqhypt	226	14	of	of	IN
cord-262253-3ovqhypt	226	15	γ	γ	NN
cord-262253-3ovqhypt	226	16	-	-	HYPH
cord-262253-3ovqhypt	226	17	secretase	secretase	NNP
cord-262253-3ovqhypt	226	18	[	[	-LRB-
cord-262253-3ovqhypt	226	19	112	112	CD
cord-262253-3ovqhypt	226	20	]	]	-RRB-
cord-262253-3ovqhypt	226	21	.	.	.
cord-262253-3ovqhypt	227	1	Foscarnet	Foscarnet	NNP
cord-262253-3ovqhypt	227	2	has	have	VBZ
cord-262253-3ovqhypt	227	3	been	be	VBN
cord-262253-3ovqhypt	227	4	tested	test	VBN
cord-262253-3ovqhypt	227	5	for	for	IN
cord-262253-3ovqhypt	227	6	its	-PRON-	PRP$
cord-262253-3ovqhypt	227	7	ability	ability	NN
cord-262253-3ovqhypt	227	8	to	to	TO
cord-262253-3ovqhypt	227	9	reduce	reduce	VB
cord-262253-3ovqhypt	227	10	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	227	11	levels	level	NNS
cord-262253-3ovqhypt	227	12	in	in	IN
cord-262253-3ovqhypt	227	13	vitro	vitro	FW
cord-262253-3ovqhypt	227	14	.	.	.
cord-262253-3ovqhypt	228	1	A	a	DT
cord-262253-3ovqhypt	228	2	study	study	NN
cord-262253-3ovqhypt	228	3	found	find	VBD
cord-262253-3ovqhypt	228	4	it	-PRON-	PRP
cord-262253-3ovqhypt	228	5	was	be	VBD
cord-262253-3ovqhypt	228	6	able	able	JJ
cord-262253-3ovqhypt	228	7	to	to	TO
cord-262253-3ovqhypt	228	8	reduce	reduce	VB
cord-262253-3ovqhypt	228	9	Aβ	Aβ	NNP
cord-262253-3ovqhypt	228	10	accumulation	accumulation	NN
cord-262253-3ovqhypt	228	11	,	,	,
cord-262253-3ovqhypt	228	12	although	although	IN
cord-262253-3ovqhypt	228	13	only	only	RB
cord-262253-3ovqhypt	228	14	at	at	IN
cord-262253-3ovqhypt	228	15	higher	high	JJR
cord-262253-3ovqhypt	228	16	doses	dose	NNS
cord-262253-3ovqhypt	228	17	.	.	.
cord-262253-3ovqhypt	229	1	It	-PRON-	PRP
cord-262253-3ovqhypt	229	2	was	be	VBD
cord-262253-3ovqhypt	229	3	also	also	RB
cord-262253-3ovqhypt	229	4	unable	unable	JJ
cord-262253-3ovqhypt	229	5	to	to	TO
cord-262253-3ovqhypt	229	6	significantly	significantly	RB
cord-262253-3ovqhypt	229	7	reduce	reduce	VB
cord-262253-3ovqhypt	229	8	virus	virus	NN
cord-262253-3ovqhypt	229	9	levels	level	NNS
cord-262253-3ovqhypt	229	10	.	.	.
cord-262253-3ovqhypt	230	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	230	2	,	,	,
cord-262253-3ovqhypt	230	3	foscarnet	foscarnet	NNP
cord-262253-3ovqhypt	230	4	was	be	VBD
cord-262253-3ovqhypt	230	5	not	not	RB
cord-262253-3ovqhypt	230	6	as	as	RB
cord-262253-3ovqhypt	230	7	effective	effective	JJ
cord-262253-3ovqhypt	230	8	as	as	IN
cord-262253-3ovqhypt	230	9	acyclovir	acyclovir	NNP
cord-262253-3ovqhypt	230	10	or	or	CC
cord-262253-3ovqhypt	230	11	penciclovir	penciclovir	NNPS
cord-262253-3ovqhypt	230	12	,	,	,
cord-262253-3ovqhypt	230	13	and	and	CC
cord-262253-3ovqhypt	230	14	hence	hence	RB
cord-262253-3ovqhypt	230	15	currently	currently	RB
cord-262253-3ovqhypt	230	16	is	be	VBZ
cord-262253-3ovqhypt	230	17	not	not	RB
cord-262253-3ovqhypt	230	18	seen	see	VBN
cord-262253-3ovqhypt	230	19	as	as	IN
cord-262253-3ovqhypt	230	20	the	the	DT
cord-262253-3ovqhypt	230	21	optimal	optimal	JJ
cord-262253-3ovqhypt	230	22	antiviral	antiviral	JJ
cord-262253-3ovqhypt	230	23	drug	drug	NN
cord-262253-3ovqhypt	230	24	available	available	JJ
cord-262253-3ovqhypt	230	25	for	for	IN
cord-262253-3ovqhypt	230	26	AD	ad	NN
cord-262253-3ovqhypt	230	27	[	[	-LRB-
cord-262253-3ovqhypt	230	28	112	112	CD
cord-262253-3ovqhypt	230	29	]	]	-RRB-
cord-262253-3ovqhypt	230	30	.	.	.
cord-262253-3ovqhypt	231	1	Valacyclovir	Valacyclovir	NNP
cord-262253-3ovqhypt	231	2	,	,	,
cord-262253-3ovqhypt	231	3	an	an	DT
cord-262253-3ovqhypt	231	4	antiviral	antiviral	JJ
cord-262253-3ovqhypt	231	5	medication	medication	NN
cord-262253-3ovqhypt	231	6	used	use	VBN
cord-262253-3ovqhypt	231	7	in	in	IN
cord-262253-3ovqhypt	231	8	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	231	9	and	and	CC
cord-262253-3ovqhypt	231	10	HSV-2	hsv-2	JJ
cord-262253-3ovqhypt	231	11	infections	infection	NNS
cord-262253-3ovqhypt	231	12	,	,	,
cord-262253-3ovqhypt	231	13	has	have	VBZ
cord-262253-3ovqhypt	231	14	been	be	VBN
cord-262253-3ovqhypt	231	15	determined	determine	VBN
cord-262253-3ovqhypt	231	16	to	to	TO
cord-262253-3ovqhypt	231	17	positively	positively	RB
cord-262253-3ovqhypt	231	18	impact	impact	VB
cord-262253-3ovqhypt	231	19	cognition	cognition	NN
cord-262253-3ovqhypt	231	20	by	by	IN
cord-262253-3ovqhypt	231	21	improving	improve	VBG
cord-262253-3ovqhypt	231	22	visual	visual	JJ
cord-262253-3ovqhypt	231	23	object	object	NN
cord-262253-3ovqhypt	231	24	learning	learning	NN
cord-262253-3ovqhypt	231	25	,	,	,
cord-262253-3ovqhypt	231	26	verbal	verbal	JJ
cord-262253-3ovqhypt	231	27	memory	memory	NN
cord-262253-3ovqhypt	231	28	and	and	CC
cord-262253-3ovqhypt	231	29	working	working	NN
cord-262253-3ovqhypt	231	30	memory	memory	NN
cord-262253-3ovqhypt	231	31	in	in	IN
cord-262253-3ovqhypt	231	32	patients	patient	NNS
cord-262253-3ovqhypt	231	33	with	with	IN
cord-262253-3ovqhypt	231	34	schizophrenia	schizophrenia	NN
cord-262253-3ovqhypt	231	35	[	[	-LRB-
cord-262253-3ovqhypt	231	36	115	115	CD
cord-262253-3ovqhypt	231	37	]	]	-RRB-
cord-262253-3ovqhypt	231	38	.	.	.
cord-262253-3ovqhypt	232	1	Due	due	IN
cord-262253-3ovqhypt	232	2	to	to	IN
cord-262253-3ovqhypt	232	3	its	-PRON-	PRP$
cord-262253-3ovqhypt	232	4	effects	effect	NNS
cord-262253-3ovqhypt	232	5	on	on	IN
cord-262253-3ovqhypt	232	6	working	work	VBG
cord-262253-3ovqhypt	232	7	memory	memory	NN
cord-262253-3ovqhypt	232	8	,	,	,
cord-262253-3ovqhypt	232	9	its	-PRON-	PRP$
cord-262253-3ovqhypt	232	10	effectiveness	effectiveness	NN
cord-262253-3ovqhypt	232	11	against	against	IN
cord-262253-3ovqhypt	232	12	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	232	13	and	and	CC
cord-262253-3ovqhypt	232	14	HSV-2	HSV-2	NNP
cord-262253-3ovqhypt	232	15	,	,	,
cord-262253-3ovqhypt	232	16	and	and	CC
cord-262253-3ovqhypt	232	17	its	-PRON-	PRP$
cord-262253-3ovqhypt	232	18	generally	generally	RB
cord-262253-3ovqhypt	232	19	safe	safe	JJ
cord-262253-3ovqhypt	232	20	consumption	consumption	NN
cord-262253-3ovqhypt	232	21	,	,	,
cord-262253-3ovqhypt	232	22	valacyclovir	valacyclovir	NNP
cord-262253-3ovqhypt	232	23	has	have	VBZ
cord-262253-3ovqhypt	232	24	been	be	VBN
cord-262253-3ovqhypt	232	25	suggested	suggest	VBN
cord-262253-3ovqhypt	232	26	as	as	IN
cord-262253-3ovqhypt	232	27	a	a	DT
cord-262253-3ovqhypt	232	28	potential	potential	JJ
cord-262253-3ovqhypt	232	29	therapeutic	therapeutic	JJ
cord-262253-3ovqhypt	232	30	for	for	IN
cord-262253-3ovqhypt	232	31	AD	ad	NN
cord-262253-3ovqhypt	232	32	.	.	.
cord-262253-3ovqhypt	233	1	A	a	DT
cord-262253-3ovqhypt	233	2	clinical	clinical	JJ
cord-262253-3ovqhypt	233	3	study	study	NN
cord-262253-3ovqhypt	233	4	is	be	VBZ
cord-262253-3ovqhypt	233	5	currently	currently	RB
cord-262253-3ovqhypt	233	6	underway	underway	JJ
cord-262253-3ovqhypt	233	7	in	in	IN
cord-262253-3ovqhypt	233	8	which	which	WDT
cord-262253-3ovqhypt	233	9	patients	patient	NNS
cord-262253-3ovqhypt	233	10	that	that	IN
cord-262253-3ovqhypt	233	11	both	both	DT
cord-262253-3ovqhypt	233	12	have	have	VBP
cord-262253-3ovqhypt	233	13	mild	mild	JJ
cord-262253-3ovqhypt	233	14	AD	ad	NN
cord-262253-3ovqhypt	233	15	and	and	CC
cord-262253-3ovqhypt	233	16	tested	test	VBD
cord-262253-3ovqhypt	233	17	positive	positive	JJ
cord-262253-3ovqhypt	233	18	for	for	IN
cord-262253-3ovqhypt	233	19	HSV-1	HSV-1	NNS
cord-262253-3ovqhypt	233	20	or	or	CC
cord-262253-3ovqhypt	233	21	HSV-2	HSV-2	NNP
cord-262253-3ovqhypt	233	22	will	will	MD
cord-262253-3ovqhypt	233	23	receive	receive	VB
cord-262253-3ovqhypt	233	24	valacyclovir	valacyclovir	NNP
cord-262253-3ovqhypt	233	25	.	.	.
cord-262253-3ovqhypt	234	1	The	the	DT
cord-262253-3ovqhypt	234	2	aim	aim	NN
cord-262253-3ovqhypt	234	3	of	of	IN
cord-262253-3ovqhypt	234	4	the	the	DT
cord-262253-3ovqhypt	234	5	study	study	NN
cord-262253-3ovqhypt	234	6	is	be	VBZ
cord-262253-3ovqhypt	234	7	to	to	TO
cord-262253-3ovqhypt	234	8	determine	determine	VB
cord-262253-3ovqhypt	234	9	the	the	DT
cord-262253-3ovqhypt	234	10	impact	impact	NN
cord-262253-3ovqhypt	234	11	of	of	IN
cord-262253-3ovqhypt	234	12	this	this	DT
cord-262253-3ovqhypt	234	13	treatment	treatment	NN
cord-262253-3ovqhypt	234	14	on	on	IN
cord-262253-3ovqhypt	234	15	cognition	cognition	NN
cord-262253-3ovqhypt	234	16	and	and	CC
cord-262253-3ovqhypt	234	17	the	the	DT
cord-262253-3ovqhypt	234	18	accumulation	accumulation	NN
cord-262253-3ovqhypt	234	19	of	of	IN
cord-262253-3ovqhypt	234	20	amyloid	amyloid	NN
cord-262253-3ovqhypt	234	21	and	and	CC
cord-262253-3ovqhypt	234	22	tau	tau	NNP
cord-262253-3ovqhypt	234	23	[	[	-LRB-
cord-262253-3ovqhypt	234	24	116	116	CD
cord-262253-3ovqhypt	234	25	]	]	-RRB-
cord-262253-3ovqhypt	234	26	.	.	.
cord-262253-3ovqhypt	235	1	Numerous	numerous	JJ
cord-262253-3ovqhypt	235	2	studies	study	NNS
cord-262253-3ovqhypt	235	3	have	have	VBP
cord-262253-3ovqhypt	235	4	determined	determine	VBN
cord-262253-3ovqhypt	235	5	the	the	DT
cord-262253-3ovqhypt	235	6	antiviral	antiviral	JJ
cord-262253-3ovqhypt	235	7	agent	agent	NN
cord-262253-3ovqhypt	235	8	Bay	Bay	NNP
cord-262253-3ovqhypt	235	9	57	57	CD
cord-262253-3ovqhypt	235	10	-	-	SYM
cord-262253-3ovqhypt	235	11	1293	1293	CD
cord-262253-3ovqhypt	235	12	to	to	TO
cord-262253-3ovqhypt	235	13	be	be	VB
cord-262253-3ovqhypt	235	14	effective	effective	JJ
cord-262253-3ovqhypt	235	15	in	in	IN
cord-262253-3ovqhypt	235	16	combating	combat	VBG
cord-262253-3ovqhypt	235	17	HSV-1	HSV-1	NNS
cord-262253-3ovqhypt	235	18	[	[	-LRB-
cord-262253-3ovqhypt	235	19	117	117	CD
cord-262253-3ovqhypt	235	20	]	]	-RRB-
cord-262253-3ovqhypt	235	21	[	[	-LRB-
cord-262253-3ovqhypt	235	22	118	118	CD
cord-262253-3ovqhypt	235	23	]	]	-RRB-
cord-262253-3ovqhypt	235	24	[	[	-LRB-
cord-262253-3ovqhypt	235	25	119	119	CD
cord-262253-3ovqhypt	235	26	]	]	-RRB-
cord-262253-3ovqhypt	235	27	[	[	-LRB-
cord-262253-3ovqhypt	235	28	120	120	CD
cord-262253-3ovqhypt	235	29	]	]	-RRB-
cord-262253-3ovqhypt	235	30	[	[	-LRB-
cord-262253-3ovqhypt	235	31	121	121	CD
cord-262253-3ovqhypt	235	32	]	]	-RRB-
cord-262253-3ovqhypt	235	33	.	.	.
cord-262253-3ovqhypt	236	1	By	by	IN
cord-262253-3ovqhypt	236	2	targeting	target	VBG
cord-262253-3ovqhypt	236	3	the	the	DT
cord-262253-3ovqhypt	236	4	helicase	helicase	NN
cord-262253-3ovqhypt	236	5	-	-	HYPH
cord-262253-3ovqhypt	236	6	primase	primase	NN
cord-262253-3ovqhypt	236	7	complex	complex	NN
cord-262253-3ovqhypt	236	8	,	,	,
cord-262253-3ovqhypt	236	9	Bay	Bay	NNP
cord-262253-3ovqhypt	236	10	57	57	CD
cord-262253-3ovqhypt	236	11	-	-	SYM
cord-262253-3ovqhypt	236	12	1293	1293	CD
cord-262253-3ovqhypt	236	13	can	can	MD
cord-262253-3ovqhypt	236	14	inhibit	inhibit	VB
cord-262253-3ovqhypt	236	15	viral	viral	JJ
cord-262253-3ovqhypt	236	16	DNA	dna	NN
cord-262253-3ovqhypt	236	17	replication	replication	NN
cord-262253-3ovqhypt	236	18	,	,	,
cord-262253-3ovqhypt	236	19	and	and	CC
cord-262253-3ovqhypt	236	20	has	have	VBZ
cord-262253-3ovqhypt	236	21	been	be	VBN
cord-262253-3ovqhypt	236	22	found	find	VBN
cord-262253-3ovqhypt	236	23	to	to	TO
cord-262253-3ovqhypt	236	24	be	be	VB
cord-262253-3ovqhypt	236	25	more	more	RBR
cord-262253-3ovqhypt	236	26	potent	potent	JJ
cord-262253-3ovqhypt	236	27	than	than	IN
cord-262253-3ovqhypt	236	28	acyclovir	acyclovir	NNP
cord-262253-3ovqhypt	236	29	.	.	.
cord-262253-3ovqhypt	237	1	The	the	DT
cord-262253-3ovqhypt	237	2	severity	severity	NN
cord-262253-3ovqhypt	237	3	and	and	CC
cord-262253-3ovqhypt	237	4	frequency	frequency	NN
cord-262253-3ovqhypt	237	5	of	of	IN
cord-262253-3ovqhypt	237	6	recurring	recur	VBG
cord-262253-3ovqhypt	237	7	HSV	HSV	NNP
cord-262253-3ovqhypt	237	8	was	be	VBD
cord-262253-3ovqhypt	237	9	also	also	RB
cord-262253-3ovqhypt	237	10	found	find	VBN
cord-262253-3ovqhypt	237	11	to	to	TO
cord-262253-3ovqhypt	237	12	be	be	VB
cord-262253-3ovqhypt	237	13	reduced	reduce	VBN
cord-262253-3ovqhypt	237	14	by	by	IN
cord-262253-3ovqhypt	237	15	use	use	NN
cord-262253-3ovqhypt	237	16	of	of	IN
cord-262253-3ovqhypt	237	17	this	this	DT
cord-262253-3ovqhypt	237	18	drug	drug	NN
cord-262253-3ovqhypt	237	19	[	[	-LRB-
cord-262253-3ovqhypt	237	20	121	121	CD
cord-262253-3ovqhypt	237	21	]	]	-RRB-
cord-262253-3ovqhypt	237	22	.	.	.
cord-262253-3ovqhypt	238	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	238	2	,	,	,
cord-262253-3ovqhypt	238	3	it	-PRON-	PRP
cord-262253-3ovqhypt	238	4	was	be	VBD
cord-262253-3ovqhypt	238	5	able	able	JJ
cord-262253-3ovqhypt	238	6	to	to	TO
cord-262253-3ovqhypt	238	7	decrease	decrease	VB
cord-262253-3ovqhypt	238	8	levels	level	NNS
cord-262253-3ovqhypt	238	9	of	of	IN
cord-262253-3ovqhypt	238	10	Aβ	Aβ	NNP
cord-262253-3ovqhypt	238	11	and	and	CC
cord-262253-3ovqhypt	238	12	reduce	reduce	VB
cord-262253-3ovqhypt	238	13	P	p	NN
cord-262253-3ovqhypt	238	14	-	-	HYPH
cord-262253-3ovqhypt	238	15	tau	tau	NN
cord-262253-3ovqhypt	238	16	production	production	NN
cord-262253-3ovqhypt	238	17	in	in	IN
cord-262253-3ovqhypt	238	18	Vero	Vero	NNP
cord-262253-3ovqhypt	238	19	cells	cell	NNS
cord-262253-3ovqhypt	238	20	infected	infect	VBN
cord-262253-3ovqhypt	238	21	with	with	IN
cord-262253-3ovqhypt	238	22	HSV-1	HSV-1	NNS
cord-262253-3ovqhypt	238	23	[	[	-LRB-
cord-262253-3ovqhypt	238	24	117	117	CD
cord-262253-3ovqhypt	238	25	]	]	-RRB-
cord-262253-3ovqhypt	238	26	.	.	.
cord-262253-3ovqhypt	239	1	Our	-PRON-	PRP$
cord-262253-3ovqhypt	239	2	lab	lab	NN
cord-262253-3ovqhypt	239	3	has	have	VBZ
cord-262253-3ovqhypt	239	4	investigated	investigate	VBN
cord-262253-3ovqhypt	239	5	the	the	DT
cord-262253-3ovqhypt	239	6	use	use	NN
cord-262253-3ovqhypt	239	7	of	of	IN
cord-262253-3ovqhypt	239	8	bioflavonoids	bioflavonoid	NNS
cord-262253-3ovqhypt	239	9	,	,	,
cord-262253-3ovqhypt	239	10	including	include	VBG
cord-262253-3ovqhypt	239	11	ginkgetin	ginkgetin	NNP
cord-262253-3ovqhypt	239	12	,	,	,
cord-262253-3ovqhypt	239	13	isoginkgetin	isoginkgetin	NNP
cord-262253-3ovqhypt	239	14	and	and	CC
cord-262253-3ovqhypt	239	15	ginkgolic	ginkgolic	JJ
cord-262253-3ovqhypt	239	16	acid	acid	NN
cord-262253-3ovqhypt	239	17	,	,	,
cord-262253-3ovqhypt	239	18	derived	derive	VBN
cord-262253-3ovqhypt	239	19	from	from	IN
cord-262253-3ovqhypt	239	20	the	the	DT
cord-262253-3ovqhypt	239	21	leaves	leave	NNS
cord-262253-3ovqhypt	239	22	of	of	IN
cord-262253-3ovqhypt	239	23	Ginkgo	Ginkgo	NNP
cord-262253-3ovqhypt	239	24	biloba	biloba	NN
cord-262253-3ovqhypt	239	25	.	.	.
cord-262253-3ovqhypt	240	1	The	the	DT
cord-262253-3ovqhypt	240	2	antiviral	antiviral	JJ
cord-262253-3ovqhypt	240	3	capabilities	capability	NNS
cord-262253-3ovqhypt	240	4	of	of	IN
cord-262253-3ovqhypt	240	5	these	these	DT
cord-262253-3ovqhypt	240	6	compounds	compound	NNS
cord-262253-3ovqhypt	240	7	has	have	VBZ
cord-262253-3ovqhypt	240	8	been	be	VBN
cord-262253-3ovqhypt	240	9	well	well	RB
cord-262253-3ovqhypt	240	10	established	establish	VBN
cord-262253-3ovqhypt	240	11	in	in	IN
cord-262253-3ovqhypt	240	12	previous	previous	JJ
cord-262253-3ovqhypt	240	13	studies	study	NNS
cord-262253-3ovqhypt	240	14	[	[	-LRB-
cord-262253-3ovqhypt	240	15	122	122	CD
cord-262253-3ovqhypt	240	16	]	]	-RRB-
cord-262253-3ovqhypt	240	17	[	[	-LRB-
cord-262253-3ovqhypt	240	18	123	123	CD
cord-262253-3ovqhypt	240	19	]	]	-RRB-
cord-262253-3ovqhypt	240	20	[	[	-LRB-
cord-262253-3ovqhypt	240	21	124	124	CD
cord-262253-3ovqhypt	240	22	]	]	-RRB-
cord-262253-3ovqhypt	241	1	[	[	-LRB-
cord-262253-3ovqhypt	241	2	125	125	CD
cord-262253-3ovqhypt	241	3	]	]	-RRB-
cord-262253-3ovqhypt	241	4	[	[	-LRB-
cord-262253-3ovqhypt	241	5	126	126	CD
cord-262253-3ovqhypt	241	6	]	]	-RRB-
cord-262253-3ovqhypt	241	7	.	.	.
cord-262253-3ovqhypt	242	1	Hayashi	Hayashi	NNP
cord-262253-3ovqhypt	242	2	et	et	NNP
cord-262253-3ovqhypt	242	3	al	al	NNP
cord-262253-3ovqhypt	242	4	.	.	.
cord-262253-3ovqhypt	243	1	determined	determine	VBD
cord-262253-3ovqhypt	243	2	ginkgetin	ginkgetin	NNP
cord-262253-3ovqhypt	243	3	to	to	TO
cord-262253-3ovqhypt	243	4	successfully	successfully	RB
cord-262253-3ovqhypt	243	5	inhibit	inhibit	VB
cord-262253-3ovqhypt	243	6	the	the	DT
cord-262253-3ovqhypt	243	7	viral	viral	JJ
cord-262253-3ovqhypt	243	8	replication	replication	NN
cord-262253-3ovqhypt	243	9	of	of	IN
cord-262253-3ovqhypt	243	10	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	243	11	,	,	,
cord-262253-3ovqhypt	243	12	HSV-2	HSV-2	NNP
cord-262253-3ovqhypt	243	13	and	and	CC
cord-262253-3ovqhypt	243	14	the	the	DT
cord-262253-3ovqhypt	243	15	human	human	JJ
cord-262253-3ovqhypt	243	16	cytomegalovirus	cytomegalovirus	NN
cord-262253-3ovqhypt	243	17	,	,	,
cord-262253-3ovqhypt	243	18	while	while	IN
cord-262253-3ovqhypt	243	19	also	also	RB
cord-262253-3ovqhypt	243	20	suppressing	suppress	VBG
cord-262253-3ovqhypt	243	21	viral	viral	JJ
cord-262253-3ovqhypt	243	22	protein	protein	NN
cord-262253-3ovqhypt	243	23	synthesis	synthesis	NN
cord-262253-3ovqhypt	243	24	[	[	-LRB-
cord-262253-3ovqhypt	243	25	122	122	CD
cord-262253-3ovqhypt	243	26	]	]	-RRB-
cord-262253-3ovqhypt	243	27	.	.	.
cord-262253-3ovqhypt	244	1	Additionally	additionally	RB
cord-262253-3ovqhypt	244	2	,	,	,
cord-262253-3ovqhypt	244	3	a	a	DT
cord-262253-3ovqhypt	244	4	study	study	NN
cord-262253-3ovqhypt	244	5	by	by	IN
cord-262253-3ovqhypt	244	6	Miki	Miki	NNP
cord-262253-3ovqhypt	244	7	et	et	NNP
cord-262253-3ovqhypt	244	8	al	al	NNP
cord-262253-3ovqhypt	244	9	.	.	NNP
cord-262253-3ovqhypt	244	10	found	find	VBD
cord-262253-3ovqhypt	244	11	ginkgetin	ginkgetin	NNP
cord-262253-3ovqhypt	244	12	to	to	TO
cord-262253-3ovqhypt	244	13	have	have	VB
cord-262253-3ovqhypt	244	14	anti	anti	JJ
cord-262253-3ovqhypt	244	15	-	-	JJ
cord-262253-3ovqhypt	244	16	influenza	influenza	JJ
cord-262253-3ovqhypt	244	17	virus	virus	NN
cord-262253-3ovqhypt	244	18	activity	activity	NN
cord-262253-3ovqhypt	244	19	[	[	-LRB-
cord-262253-3ovqhypt	244	20	123	123	CD
cord-262253-3ovqhypt	244	21	]	]	-RRB-
cord-262253-3ovqhypt	244	22	.	.	.
cord-262253-3ovqhypt	245	1	Ginkgetin	Ginkgetin	NNP
cord-262253-3ovqhypt	245	2	has	have	VBZ
cord-262253-3ovqhypt	245	3	been	be	VBN
cord-262253-3ovqhypt	245	4	studied	study	VBN
cord-262253-3ovqhypt	245	5	for	for	IN
cord-262253-3ovqhypt	245	6	use	use	NN
cord-262253-3ovqhypt	245	7	in	in	IN
cord-262253-3ovqhypt	245	8	AD	ad	NN
cord-262253-3ovqhypt	245	9	by	by	IN
cord-262253-3ovqhypt	245	10	Zeng	Zeng	NNP
cord-262253-3ovqhypt	245	11	et	et	FW
cord-262253-3ovqhypt	245	12	al	al	NNP
cord-262253-3ovqhypt	245	13	.	.	NNP
cord-262253-3ovqhypt	245	14	,	,	,
cord-262253-3ovqhypt	245	15	who	who	WP
cord-262253-3ovqhypt	245	16	administered	administer	VBD
cord-262253-3ovqhypt	245	17	the	the	DT
cord-262253-3ovqhypt	245	18	drug	drug	NN
cord-262253-3ovqhypt	245	19	to	to	TO
cord-262253-3ovqhypt	245	20	APP	app	NN
cord-262253-3ovqhypt	245	21	/	/	SYM
cord-262253-3ovqhypt	245	22	PS1	ps1	JJ
cord-262253-3ovqhypt	245	23	transgenic	transgenic	JJ
cord-262253-3ovqhypt	245	24	mice	mouse	NNS
cord-262253-3ovqhypt	245	25	.	.	.
cord-262253-3ovqhypt	246	1	They	-PRON-	PRP
cord-262253-3ovqhypt	246	2	observed	observe	VBD
cord-262253-3ovqhypt	246	3	a	a	DT
cord-262253-3ovqhypt	246	4	significant	significant	JJ
cord-262253-3ovqhypt	246	5	reduction	reduction	NN
cord-262253-3ovqhypt	246	6	in	in	IN
cord-262253-3ovqhypt	246	7	Aβ	Aβ	NNP
cord-262253-3ovqhypt	246	8	plaques	plaque	NNS
cord-262253-3ovqhypt	246	9	and	and	CC
cord-262253-3ovqhypt	246	10	an	an	DT
cord-262253-3ovqhypt	246	11	improvement	improvement	NN
cord-262253-3ovqhypt	246	12	in	in	IN
cord-262253-3ovqhypt	246	13	inflammation	inflammation	NN
cord-262253-3ovqhypt	246	14	[	[	-LRB-
cord-262253-3ovqhypt	246	15	127	127	CD
cord-262253-3ovqhypt	246	16	]	]	-RRB-
cord-262253-3ovqhypt	246	17	.	.	.
cord-262253-3ovqhypt	247	1	Borenstein	Borenstein	NNP
cord-262253-3ovqhypt	247	2	et	et	NNP
cord-262253-3ovqhypt	247	3	al	al	NNP
cord-262253-3ovqhypt	247	4	.	.	NNP
cord-262253-3ovqhypt	247	5	have	have	VBP
cord-262253-3ovqhypt	247	6	demonstrated	demonstrate	VBN
cord-262253-3ovqhypt	247	7	the	the	DT
cord-262253-3ovqhypt	247	8	ability	ability	NN
cord-262253-3ovqhypt	247	9	of	of	IN
cord-262253-3ovqhypt	247	10	ginkgolic	ginkgolic	JJ
cord-262253-3ovqhypt	247	11	acid	acid	NN
cord-262253-3ovqhypt	247	12	to	to	TO
cord-262253-3ovqhypt	247	13	limit	limit	VB
cord-262253-3ovqhypt	247	14	virus	virus	NN
cord-262253-3ovqhypt	247	15	infectivity	infectivity	NN
cord-262253-3ovqhypt	247	16	by	by	IN
cord-262253-3ovqhypt	247	17	inhibiting	inhibit	VBG
cord-262253-3ovqhypt	247	18	its	-PRON-	PRP$
cord-262253-3ovqhypt	247	19	fusion	fusion	NN
cord-262253-3ovqhypt	247	20	.	.	.
cord-262253-3ovqhypt	248	1	The	the	DT
cord-262253-3ovqhypt	248	2	study	study	NN
cord-262253-3ovqhypt	248	3	found	find	VBD
cord-262253-3ovqhypt	248	4	ginkgolic	ginkgolic	JJ
cord-262253-3ovqhypt	248	5	acid	acid	NN
cord-262253-3ovqhypt	248	6	to	to	TO
cord-262253-3ovqhypt	248	7	be	be	VB
cord-262253-3ovqhypt	248	8	successful	successful	JJ
cord-262253-3ovqhypt	248	9	in	in	IN
cord-262253-3ovqhypt	248	10	inhibiting	inhibit	VBG
cord-262253-3ovqhypt	248	11	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	248	12	,	,	,
cord-262253-3ovqhypt	248	13	human	human	JJ
cord-262253-3ovqhypt	248	14	cytomegalovirus	cytomegalovirus	NNP
cord-262253-3ovqhypt	248	15	and	and	CC
cord-262253-3ovqhypt	248	16	zika	zika	NNP
cord-262253-3ovqhypt	248	17	virus	virus	NN
cord-262253-3ovqhypt	248	18	.	.	.
cord-262253-3ovqhypt	249	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	249	2	,	,	,
cord-262253-3ovqhypt	249	3	it	-PRON-	PRP
cord-262253-3ovqhypt	249	4	was	be	VBD
cord-262253-3ovqhypt	249	5	effective	effective	JJ
cord-262253-3ovqhypt	249	6	in	in	IN
cord-262253-3ovqhypt	249	7	inhibiting	inhibit	VBG
cord-262253-3ovqhypt	249	8	viral	viral	JJ
cord-262253-3ovqhypt	249	9	protein	protein	NN
cord-262253-3ovqhypt	249	10	synthesis	synthesis	NN
cord-262253-3ovqhypt	249	11	and	and	CC
cord-262253-3ovqhypt	249	12	genome	genome	NN
cord-262253-3ovqhypt	249	13	replication	replication	NN
cord-262253-3ovqhypt	249	14	,	,	,
cord-262253-3ovqhypt	249	15	in	in	IN
cord-262253-3ovqhypt	249	16	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	249	17	and	and	CC
cord-262253-3ovqhypt	249	18	human	human	JJ
cord-262253-3ovqhypt	249	19	cytomegalovirus	cytomegalovirus	NN
cord-262253-3ovqhypt	249	20	,	,	,
cord-262253-3ovqhypt	249	21	respectively	respectively	RB
cord-262253-3ovqhypt	249	22	[	[	-LRB-
cord-262253-3ovqhypt	249	23	124	124	CD
cord-262253-3ovqhypt	249	24	]	]	-RRB-
cord-262253-3ovqhypt	249	25	.	.	.
cord-262253-3ovqhypt	250	1	Ginkgolic	ginkgolic	JJ
cord-262253-3ovqhypt	250	2	acid	acid	NN
cord-262253-3ovqhypt	250	3	has	have	VBZ
cord-262253-3ovqhypt	250	4	also	also	RB
cord-262253-3ovqhypt	250	5	demonstrated	demonstrate	VBN
cord-262253-3ovqhypt	250	6	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	250	7	properties	property	NNS
cord-262253-3ovqhypt	250	8	,	,	,
cord-262253-3ovqhypt	250	9	specifically	specifically	RB
cord-262253-3ovqhypt	250	10	against	against	IN
cord-262253-3ovqhypt	250	11	E.	E.	NNP
cord-262253-3ovqhypt	250	12	coli	coli	NNS
cord-262253-3ovqhypt	250	13	and	and	CC
cord-262253-3ovqhypt	250	14	Staphlylococcus	Staphlylococcus	NNP
cord-262253-3ovqhypt	250	15	aureus	aureus	NNP
cord-262253-3ovqhypt	250	16	[	[	-LRB-
cord-262253-3ovqhypt	250	17	125	125	CD
cord-262253-3ovqhypt	250	18	]	]	-RRB-
cord-262253-3ovqhypt	250	19	.	.	.
cord-262253-3ovqhypt	251	1	Isoginkgetin	Isoginkgetin	NNP
cord-262253-3ovqhypt	251	2	has	have	VBZ
cord-262253-3ovqhypt	251	3	been	be	VBN
cord-262253-3ovqhypt	251	4	shown	show	VBN
cord-262253-3ovqhypt	251	5	to	to	TO
cord-262253-3ovqhypt	251	6	provide	provide	VB
cord-262253-3ovqhypt	251	7	neuroprotection	neuroprotection	NN
cord-262253-3ovqhypt	251	8	against	against	IN
cord-262253-3ovqhypt	251	9	the	the	DT
cord-262253-3ovqhypt	251	10	cytotoxic	cytotoxic	JJ
cord-262253-3ovqhypt	251	11	effects	effect	NNS
cord-262253-3ovqhypt	251	12	of	of	IN
cord-262253-3ovqhypt	251	13	excessive	excessive	JJ
cord-262253-3ovqhypt	251	14	Aβ	Aβ	NNP
cord-262253-3ovqhypt	251	15	accumulation	accumulation	NN
cord-262253-3ovqhypt	251	16	[	[	-LRB-
cord-262253-3ovqhypt	251	17	128	128	CD
cord-262253-3ovqhypt	251	18	,	,	,
cord-262253-3ovqhypt	251	19	129	129	CD
cord-262253-3ovqhypt	251	20	]	]	-RRB-
cord-262253-3ovqhypt	251	21	,	,	,
cord-262253-3ovqhypt	251	22	while	while	IN
cord-262253-3ovqhypt	251	23	also	also	RB
cord-262253-3ovqhypt	251	24	having	have	VBG
cord-262253-3ovqhypt	251	25	anti	anti	JJ
cord-262253-3ovqhypt	251	26	-	-	JJ
cord-262253-3ovqhypt	251	27	microbial	microbial	JJ
cord-262253-3ovqhypt	251	28	and	and	CC
cord-262253-3ovqhypt	251	29	anti	anti	JJ
cord-262253-3ovqhypt	251	30	-	-	JJ
cord-262253-3ovqhypt	251	31	fungal	fungal	JJ
cord-262253-3ovqhypt	251	32	activity	activity	NN
cord-262253-3ovqhypt	251	33	[	[	-LRB-
cord-262253-3ovqhypt	251	34	126	126	CD
cord-262253-3ovqhypt	251	35	]	]	-RRB-
cord-262253-3ovqhypt	251	36	.	.	.
cord-262253-3ovqhypt	252	1	Our	-PRON-	PRP$
cord-262253-3ovqhypt	252	2	lab	lab	NN
cord-262253-3ovqhypt	252	3	's	's	POS
cord-262253-3ovqhypt	252	4	preliminary	preliminary	JJ
cord-262253-3ovqhypt	252	5	work	work	NN
cord-262253-3ovqhypt	252	6	in	in	IN
cord-262253-3ovqhypt	252	7	testing	test	VBG
cord-262253-3ovqhypt	252	8	these	these	DT
cord-262253-3ovqhypt	252	9	three	three	CD
cord-262253-3ovqhypt	252	10	compounds	compound	NNS
cord-262253-3ovqhypt	252	11	in	in	IN
cord-262253-3ovqhypt	252	12	AD	ad	NN
cord-262253-3ovqhypt	252	13	determined	determine	VBD
cord-262253-3ovqhypt	252	14	their	-PRON-	PRP$
cord-262253-3ovqhypt	252	15	effectiveness	effectiveness	NN
cord-262253-3ovqhypt	252	16	in	in	IN
cord-262253-3ovqhypt	252	17	reducing	reduce	VBG
cord-262253-3ovqhypt	252	18	Aβ	Aβ	NNP
cord-262253-3ovqhypt	252	19	load	load	NN
cord-262253-3ovqhypt	252	20	in	in	IN
cord-262253-3ovqhypt	252	21	vitro	vitro	FW
cord-262253-3ovqhypt	252	22	,	,	,
cord-262253-3ovqhypt	252	23	further	further	RB
cord-262253-3ovqhypt	252	24	supporting	support	VBG
cord-262253-3ovqhypt	252	25	their	-PRON-	PRP$
cord-262253-3ovqhypt	252	26	therapeutic	therapeutic	JJ
cord-262253-3ovqhypt	252	27	potential	potential	NN
cord-262253-3ovqhypt	252	28	in	in	IN
cord-262253-3ovqhypt	252	29	AD	ad	NN
cord-262253-3ovqhypt	252	30	.	.	.
cord-262253-3ovqhypt	253	1	Doxycycline	Doxycycline	NNP
cord-262253-3ovqhypt	253	2	is	be	VBZ
cord-262253-3ovqhypt	253	3	a	a	DT
cord-262253-3ovqhypt	253	4	tetracycline	tetracycline	NN
cord-262253-3ovqhypt	253	5	antibiotic	antibiotic	NN
cord-262253-3ovqhypt	253	6	that	that	WDT
cord-262253-3ovqhypt	253	7	has	have	VBZ
cord-262253-3ovqhypt	253	8	been	be	VBN
cord-262253-3ovqhypt	253	9	studied	study	VBN
cord-262253-3ovqhypt	253	10	for	for	IN
cord-262253-3ovqhypt	253	11	its	-PRON-	PRP$
cord-262253-3ovqhypt	253	12	therapeutic	therapeutic	JJ
cord-262253-3ovqhypt	253	13	efficacy	efficacy	NN
cord-262253-3ovqhypt	253	14	in	in	IN
cord-262253-3ovqhypt	253	15	AD	ad	NN
cord-262253-3ovqhypt	253	16	models	model	NNS
cord-262253-3ovqhypt	253	17	.	.	.
cord-262253-3ovqhypt	254	1	Contrary	contrary	JJ
cord-262253-3ovqhypt	254	2	to	to	IN
cord-262253-3ovqhypt	254	3	other	other	JJ
cord-262253-3ovqhypt	254	4	tetracyclines	tetracycline	NNS
cord-262253-3ovqhypt	254	5	,	,	,
cord-262253-3ovqhypt	254	6	doxycycline	doxycycline	NNP
cord-262253-3ovqhypt	254	7	has	have	VBZ
cord-262253-3ovqhypt	254	8	been	be	VBN
cord-262253-3ovqhypt	254	9	determined	determine	VBN
cord-262253-3ovqhypt	254	10	to	to	TO
cord-262253-3ovqhypt	254	11	be	be	VB
cord-262253-3ovqhypt	254	12	safe	safe	JJ
cord-262253-3ovqhypt	254	13	and	and	CC
cord-262253-3ovqhypt	254	14	is	be	VBZ
cord-262253-3ovqhypt	254	15	able	able	JJ
cord-262253-3ovqhypt	254	16	to	to	TO
cord-262253-3ovqhypt	254	17	penetrate	penetrate	VB
cord-262253-3ovqhypt	254	18	the	the	DT
cord-262253-3ovqhypt	254	19	BBB	BBB	NNP
cord-262253-3ovqhypt	254	20	[	[	-LRB-
cord-262253-3ovqhypt	254	21	130	130	CD
cord-262253-3ovqhypt	254	22	]	]	-RRB-
cord-262253-3ovqhypt	254	23	,	,	,
cord-262253-3ovqhypt	254	24	allowing	allow	VBG
cord-262253-3ovqhypt	254	25	it	-PRON-	PRP
cord-262253-3ovqhypt	254	26	to	to	TO
cord-262253-3ovqhypt	254	27	exert	exert	VB
cord-262253-3ovqhypt	254	28	its	-PRON-	PRP$
cord-262253-3ovqhypt	254	29	effect	effect	NN
cord-262253-3ovqhypt	254	30	directly	directly	RB
cord-262253-3ovqhypt	254	31	in	in	IN
cord-262253-3ovqhypt	254	32	the	the	DT
cord-262253-3ovqhypt	254	33	CNS	CNS	NNP
cord-262253-3ovqhypt	254	34	.	.	.
cord-262253-3ovqhypt	255	1	In	in	IN
cord-262253-3ovqhypt	255	2	vivo	vivo	NN
cord-262253-3ovqhypt	255	3	models	model	NNS
cord-262253-3ovqhypt	255	4	,	,	,
cord-262253-3ovqhypt	255	5	in	in	IN
cord-262253-3ovqhypt	255	6	which	which	WDT
cord-262253-3ovqhypt	255	7	doxycycline	doxycycline	NNP
cord-262253-3ovqhypt	255	8	was	be	VBD
cord-262253-3ovqhypt	255	9	administered	administer	VBN
cord-262253-3ovqhypt	255	10	to	to	IN
cord-262253-3ovqhypt	255	11	mice	mouse	NNS
cord-262253-3ovqhypt	255	12	,	,	,
cord-262253-3ovqhypt	255	13	observed	observe	VBD
cord-262253-3ovqhypt	255	14	its	-PRON-	PRP$
cord-262253-3ovqhypt	255	15	accumulation	accumulation	NN
cord-262253-3ovqhypt	255	16	in	in	IN
cord-262253-3ovqhypt	255	17	amyloid	amyloid	NN
cord-262253-3ovqhypt	255	18	deposits	deposit	NNS
cord-262253-3ovqhypt	255	19	,	,	,
cord-262253-3ovqhypt	255	20	including	include	VBG
cord-262253-3ovqhypt	255	21	Aβ	Aβ	NNP
cord-262253-3ovqhypt	255	22	plaques	plaque	NNS
cord-262253-3ovqhypt	255	23	[	[	-LRB-
cord-262253-3ovqhypt	255	24	131	131	CD
cord-262253-3ovqhypt	255	25	]	]	-RRB-
cord-262253-3ovqhypt	255	26	.	.	.
cord-262253-3ovqhypt	256	1	With	with	IN
cord-262253-3ovqhypt	256	2	respect	respect	NN
cord-262253-3ovqhypt	256	3	to	to	IN
cord-262253-3ovqhypt	256	4	the	the	DT
cord-262253-3ovqhypt	256	5	production	production	NN
cord-262253-3ovqhypt	256	6	and	and	CC
cord-262253-3ovqhypt	256	7	formation	formation	NN
cord-262253-3ovqhypt	256	8	of	of	IN
cord-262253-3ovqhypt	256	9	Aβ	Aβ	NNP
cord-262253-3ovqhypt	256	10	oligomers	oligomer	NNS
cord-262253-3ovqhypt	256	11	,	,	,
cord-262253-3ovqhypt	256	12	it	-PRON-	PRP
cord-262253-3ovqhypt	256	13	was	be	VBD
cord-262253-3ovqhypt	256	14	observed	observe	VBN
cord-262253-3ovqhypt	256	15	that	that	IN
cord-262253-3ovqhypt	256	16	although	although	IN
cord-262253-3ovqhypt	256	17	doxycycline	doxycycline	NNP
cord-262253-3ovqhypt	256	18	administration	administration	NN
cord-262253-3ovqhypt	256	19	in	in	IN
cord-262253-3ovqhypt	256	20	transgenic	transgenic	JJ
cord-262253-3ovqhypt	256	21	mice	mouse	NNS
cord-262253-3ovqhypt	256	22	did	do	VBD
cord-262253-3ovqhypt	256	23	not	not	RB
cord-262253-3ovqhypt	256	24	cause	cause	VB
cord-262253-3ovqhypt	256	25	a	a	DT
cord-262253-3ovqhypt	256	26	shift	shift	NN
cord-262253-3ovqhypt	256	27	in	in	IN
cord-262253-3ovqhypt	256	28	Aβ	Aβ	NNP
cord-262253-3ovqhypt	256	29	monomers	monomer	NNS
cord-262253-3ovqhypt	256	30	,	,	,
cord-262253-3ovqhypt	256	31	there	there	EX
cord-262253-3ovqhypt	256	32	was	be	VBD
cord-262253-3ovqhypt	256	33	a	a	DT
cord-262253-3ovqhypt	256	34	significant	significant	JJ
cord-262253-3ovqhypt	256	35	reduction	reduction	NN
cord-262253-3ovqhypt	256	36	in	in	IN
cord-262253-3ovqhypt	256	37	Aβ	Aβ	NNP
cord-262253-3ovqhypt	256	38	18-mer	18-mer	CD
cord-262253-3ovqhypt	256	39	levels	level	NNS
cord-262253-3ovqhypt	256	40	when	when	WRB
cord-262253-3ovqhypt	256	41	compared	compare	VBN
cord-262253-3ovqhypt	256	42	to	to	TO
cord-262253-3ovqhypt	256	43	control	control	VB
cord-262253-3ovqhypt	256	44	[	[	-LRB-
cord-262253-3ovqhypt	256	45	132	132	CD
cord-262253-3ovqhypt	256	46	]	]	-RRB-
cord-262253-3ovqhypt	256	47	.	.	.
cord-262253-3ovqhypt	257	1	The	the	DT
cord-262253-3ovqhypt	257	2	same	same	JJ
cord-262253-3ovqhypt	257	3	study	study	NN
cord-262253-3ovqhypt	257	4	also	also	RB
cord-262253-3ovqhypt	257	5	observed	observe	VBD
cord-262253-3ovqhypt	257	6	a	a	DT
cord-262253-3ovqhypt	257	7	significant	significant	JJ
cord-262253-3ovqhypt	257	8	memory	memory	NN
cord-262253-3ovqhypt	257	9	recovery	recovery	NN
cord-262253-3ovqhypt	257	10	in	in	IN
cord-262253-3ovqhypt	257	11	animals	animal	NNS
cord-262253-3ovqhypt	257	12	that	that	WDT
cord-262253-3ovqhypt	257	13	received	receive	VBD
cord-262253-3ovqhypt	257	14	treatment	treatment	NN
cord-262253-3ovqhypt	257	15	;	;	:
cord-262253-3ovqhypt	257	16	however	however	RB
cord-262253-3ovqhypt	257	17	,	,	,
cord-262253-3ovqhypt	257	18	there	there	EX
cord-262253-3ovqhypt	257	19	was	be	VBD
cord-262253-3ovqhypt	257	20	no	no	DT
cord-262253-3ovqhypt	257	21	reduction	reduction	NN
cord-262253-3ovqhypt	257	22	in	in	IN
cord-262253-3ovqhypt	257	23	Aβ	Aβ	NNP
cord-262253-3ovqhypt	257	24	plaque	plaque	NN
cord-262253-3ovqhypt	257	25	size	size	NN
cord-262253-3ovqhypt	257	26	[	[	-LRB-
cord-262253-3ovqhypt	257	27	132	132	CD
cord-262253-3ovqhypt	257	28	]	]	-RRB-
cord-262253-3ovqhypt	257	29	.	.	.
cord-262253-3ovqhypt	258	1	The	the	DT
cord-262253-3ovqhypt	258	2	paper	paper	NN
cord-262253-3ovqhypt	258	3	suggested	suggest	VBD
cord-262253-3ovqhypt	258	4	this	this	DT
cord-262253-3ovqhypt	258	5	was	be	VBD
cord-262253-3ovqhypt	258	6	possibly	possibly	RB
cord-262253-3ovqhypt	258	7	due	due	JJ
cord-262253-3ovqhypt	258	8	to	to	IN
cord-262253-3ovqhypt	258	9	the	the	DT
cord-262253-3ovqhypt	258	10	short	short	JJ
cord-262253-3ovqhypt	258	11	two	two	CD
cord-262253-3ovqhypt	258	12	-	-	HYPH
cord-262253-3ovqhypt	258	13	month	month	NN
cord-262253-3ovqhypt	258	14	period	period	NN
cord-262253-3ovqhypt	258	15	of	of	IN
cord-262253-3ovqhypt	258	16	the	the	DT
cord-262253-3ovqhypt	258	17	study	study	NN
cord-262253-3ovqhypt	258	18	,	,	,
cord-262253-3ovqhypt	258	19	as	as	IN
cord-262253-3ovqhypt	258	20	a	a	DT
cord-262253-3ovqhypt	258	21	previous	previous	JJ
cord-262253-3ovqhypt	258	22	three	three	CD
cord-262253-3ovqhypt	258	23	-	-	HYPH
cord-262253-3ovqhypt	258	24	month	month	NN
cord-262253-3ovqhypt	258	25	study	study	NN
cord-262253-3ovqhypt	258	26	found	find	VBD
cord-262253-3ovqhypt	258	27	plaque	plaque	NN
cord-262253-3ovqhypt	258	28	size	size	NN
cord-262253-3ovqhypt	258	29	to	to	TO
cord-262253-3ovqhypt	258	30	be	be	VB
cord-262253-3ovqhypt	258	31	significantly	significantly	RB
cord-262253-3ovqhypt	258	32	reduced	reduce	VBN
cord-262253-3ovqhypt	258	33	[	[	-LRB-
cord-262253-3ovqhypt	258	34	132	132	CD
cord-262253-3ovqhypt	258	35	]	]	-RRB-
cord-262253-3ovqhypt	258	36	.	.	.
cord-262253-3ovqhypt	259	1	In	in	IN
cord-262253-3ovqhypt	259	2	respect	respect	NN
cord-262253-3ovqhypt	259	3	to	to	IN
cord-262253-3ovqhypt	259	4	neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	259	5	,	,	,
cord-262253-3ovqhypt	259	6	a	a	DT
cord-262253-3ovqhypt	259	7	reduction	reduction	NN
cord-262253-3ovqhypt	259	8	in	in	IN
cord-262253-3ovqhypt	259	9	microglia	microglia	JJ
cord-262253-3ovqhypt	259	10	activation	activation	NN
cord-262253-3ovqhypt	259	11	has	have	VBZ
cord-262253-3ovqhypt	259	12	also	also	RB
cord-262253-3ovqhypt	259	13	been	be	VBN
cord-262253-3ovqhypt	259	14	associated	associate	VBN
cord-262253-3ovqhypt	259	15	with	with	IN
cord-262253-3ovqhypt	259	16	doxycycline	doxycycline	NNP
cord-262253-3ovqhypt	259	17	administration	administration	NN
cord-262253-3ovqhypt	259	18	[	[	-LRB-
cord-262253-3ovqhypt	259	19	132	132	CD
cord-262253-3ovqhypt	259	20	]	]	-RRB-
cord-262253-3ovqhypt	259	21	.	.	.
cord-262253-3ovqhypt	260	1	A	a	DT
cord-262253-3ovqhypt	260	2	drosophila	drosophila	NN
cord-262253-3ovqhypt	260	3	model	model	NN
cord-262253-3ovqhypt	260	4	,	,	,
cord-262253-3ovqhypt	260	5	which	which	WDT
cord-262253-3ovqhypt	260	6	administered	administer	VBD
cord-262253-3ovqhypt	260	7	doxycycline	doxycycline	NN
cord-262253-3ovqhypt	260	8	to	to	IN
cord-262253-3ovqhypt	260	9	Aβ	Aβ	NNP
cord-262253-3ovqhypt	260	10	1	1	CD
cord-262253-3ovqhypt	260	11	-	-	SYM
cord-262253-3ovqhypt	260	12	42	42	CD
cord-262253-3ovqhypt	260	13	-expressing	-expressing	NN
cord-262253-3ovqhypt	260	14	flies	fly	NNS
cord-262253-3ovqhypt	260	15	,	,	,
cord-262253-3ovqhypt	260	16	observed	observe	VBD
cord-262253-3ovqhypt	260	17	that	that	IN
cord-262253-3ovqhypt	260	18	the	the	DT
cord-262253-3ovqhypt	260	19	treated	treated	JJ
cord-262253-3ovqhypt	260	20	group	group	NN
cord-262253-3ovqhypt	260	21	's	's	POS
cord-262253-3ovqhypt	260	22	locomotor	locomotor	NN
cord-262253-3ovqhypt	260	23	deficits	deficit	NNS
cord-262253-3ovqhypt	260	24	developed	develop	VBD
cord-262253-3ovqhypt	260	25	slower	slow	JJR
cord-262253-3ovqhypt	260	26	than	than	IN
cord-262253-3ovqhypt	260	27	the	the	DT
cord-262253-3ovqhypt	260	28	control	control	NN
cord-262253-3ovqhypt	260	29	group	group	NN
cord-262253-3ovqhypt	260	30	.	.	.
cord-262253-3ovqhypt	261	1	The	the	DT
cord-262253-3ovqhypt	261	2	same	same	JJ
cord-262253-3ovqhypt	261	3	study	study	NN
cord-262253-3ovqhypt	261	4	also	also	RB
cord-262253-3ovqhypt	261	5	observed	observe	VBD
cord-262253-3ovqhypt	261	6	doxycycline	doxycycline	NNP
cord-262253-3ovqhypt	261	7	administration	administration	NN
cord-262253-3ovqhypt	261	8	to	to	TO
cord-262253-3ovqhypt	261	9	be	be	VB
cord-262253-3ovqhypt	261	10	associated	associate	VBN
cord-262253-3ovqhypt	261	11	with	with	IN
cord-262253-3ovqhypt	261	12	reduced	reduce	VBN
cord-262253-3ovqhypt	261	13	Aβ	Aβ	NNP
cord-262253-3ovqhypt	261	14	fibrilization	fibrilization	NN
cord-262253-3ovqhypt	261	15	,	,	,
cord-262253-3ovqhypt	261	16	suggesting	suggest	VBG
cord-262253-3ovqhypt	261	17	the	the	DT
cord-262253-3ovqhypt	261	18	production	production	NN
cord-262253-3ovqhypt	261	19	of	of	IN
cord-262253-3ovqhypt	261	20	smaller	small	JJR
cord-262253-3ovqhypt	261	21	amyloid	amyloid	NN
cord-262253-3ovqhypt	261	22	structures	structure	NNS
cord-262253-3ovqhypt	261	23	[	[	-LRB-
cord-262253-3ovqhypt	261	24	133	133	CD
cord-262253-3ovqhypt	261	25	]	]	-RRB-
cord-262253-3ovqhypt	261	26	.	.	.
cord-262253-3ovqhypt	262	1	Another	another	DT
cord-262253-3ovqhypt	262	2	study	study	NN
cord-262253-3ovqhypt	262	3	associated	associate	VBD
cord-262253-3ovqhypt	262	4	doxycycline	doxycycline	NN
cord-262253-3ovqhypt	262	5	with	with	IN
cord-262253-3ovqhypt	262	6	the	the	DT
cord-262253-3ovqhypt	262	7	destabilization	destabilization	NN
cord-262253-3ovqhypt	262	8	of	of	IN
cord-262253-3ovqhypt	262	9	Aβ	Aβ	NNP
cord-262253-3ovqhypt	262	10	fibrils	fibril	NNS
cord-262253-3ovqhypt	262	11	[	[	-LRB-
cord-262253-3ovqhypt	262	12	134	134	CD
cord-262253-3ovqhypt	262	13	]	]	-RRB-
cord-262253-3ovqhypt	262	14	.	.	.
cord-262253-3ovqhypt	263	1	Clinical	clinical	JJ
cord-262253-3ovqhypt	263	2	trials	trial	NNS
cord-262253-3ovqhypt	263	3	,	,	,
cord-262253-3ovqhypt	263	4	however	however	RB
cord-262253-3ovqhypt	263	5	,	,	,
cord-262253-3ovqhypt	263	6	were	be	VBD
cord-262253-3ovqhypt	263	7	not	not	RB
cord-262253-3ovqhypt	263	8	as	as	RB
cord-262253-3ovqhypt	263	9	successful	successful	JJ
cord-262253-3ovqhypt	263	10	.	.	.
cord-262253-3ovqhypt	264	1	One	one	CD
cord-262253-3ovqhypt	264	2	study	study	NN
cord-262253-3ovqhypt	264	3	,	,	,
cord-262253-3ovqhypt	264	4	which	which	WDT
cord-262253-3ovqhypt	264	5	administered	administer	VBD
cord-262253-3ovqhypt	264	6	doxycycline	doxycycline	NN
cord-262253-3ovqhypt	264	7	and	and	CC
cord-262253-3ovqhypt	264	8	rifampicin	rifampicin	NNS
cord-262253-3ovqhypt	264	9	,	,	,
cord-262253-3ovqhypt	264	10	observed	observe	VBD
cord-262253-3ovqhypt	264	11	improvements	improvement	NNS
cord-262253-3ovqhypt	264	12	in	in	IN
cord-262253-3ovqhypt	264	13	cognitive	cognitive	JJ
cord-262253-3ovqhypt	264	14	function	function	NN
cord-262253-3ovqhypt	264	15	,	,	,
cord-262253-3ovqhypt	264	16	as	as	IN
cord-262253-3ovqhypt	264	17	assessed	assess	VBN
cord-262253-3ovqhypt	264	18	by	by	IN
cord-262253-3ovqhypt	264	19	the	the	DT
cord-262253-3ovqhypt	264	20	Standardized	Standardized	NNP
cord-262253-3ovqhypt	264	21	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	264	22	's	's	POS
cord-262253-3ovqhypt	264	23	Disease	Disease	NNP
cord-262253-3ovqhypt	264	24	Assessment	Assessment	NNP
cord-262253-3ovqhypt	264	25	Scale	Scale	NNP
cord-262253-3ovqhypt	264	26	-	-	HYPH
cord-262253-3ovqhypt	264	27	Cognitive	Cognitive	NNP
cord-262253-3ovqhypt	264	28	Subscale	Subscale	NNP
cord-262253-3ovqhypt	264	29	(	(	-LRB-
cord-262253-3ovqhypt	264	30	SADAScog	sadascog	NN
cord-262253-3ovqhypt	264	31	)	)	-RRB-
cord-262253-3ovqhypt	264	32	score	score	NN
cord-262253-3ovqhypt	264	33	[	[	-LRB-
cord-262253-3ovqhypt	264	34	135	135	CD
cord-262253-3ovqhypt	264	35	]	]	-RRB-
cord-262253-3ovqhypt	264	36	.	.	.
cord-262253-3ovqhypt	265	1	However	however	RB
cord-262253-3ovqhypt	265	2	,	,	,
cord-262253-3ovqhypt	265	3	a	a	DT
cord-262253-3ovqhypt	265	4	second	second	JJ
cord-262253-3ovqhypt	265	5	study	study	NN
cord-262253-3ovqhypt	265	6	did	do	VBD
cord-262253-3ovqhypt	265	7	not	not	RB
cord-262253-3ovqhypt	265	8	find	find	VB
cord-262253-3ovqhypt	265	9	any	any	DT
cord-262253-3ovqhypt	265	10	improvements	improvement	NNS
cord-262253-3ovqhypt	265	11	in	in	IN
cord-262253-3ovqhypt	265	12	the	the	DT
cord-262253-3ovqhypt	265	13	cognition	cognition	NN
cord-262253-3ovqhypt	265	14	or	or	CC
cord-262253-3ovqhypt	265	15	function	function	NN
cord-262253-3ovqhypt	265	16	of	of	IN
cord-262253-3ovqhypt	265	17	patients	patient	NNS
cord-262253-3ovqhypt	265	18	with	with	IN
cord-262253-3ovqhypt	265	19	mild	mild	JJ
cord-262253-3ovqhypt	265	20	to	to	IN
cord-262253-3ovqhypt	265	21	moderate	moderate	JJ
cord-262253-3ovqhypt	265	22	AD	ad	NN
cord-262253-3ovqhypt	265	23	with	with	IN
cord-262253-3ovqhypt	265	24	doxycycline	doxycycline	NN
cord-262253-3ovqhypt	265	25	/	/	SYM
cord-262253-3ovqhypt	265	26	rifampicin	rifampicin	NNP
cord-262253-3ovqhypt	265	27	administration	administration	NNP
cord-262253-3ovqhypt	265	28	[	[	-LRB-
cord-262253-3ovqhypt	265	29	136	136	CD
cord-262253-3ovqhypt	265	30	]	]	-RRB-
cord-262253-3ovqhypt	265	31	.	.	.
cord-262253-3ovqhypt	266	1	Further	further	JJ
cord-262253-3ovqhypt	266	2	investigations	investigation	NNS
cord-262253-3ovqhypt	266	3	would	would	MD
cord-262253-3ovqhypt	266	4	be	be	VB
cord-262253-3ovqhypt	266	5	needed	need	VBN
cord-262253-3ovqhypt	266	6	to	to	TO
cord-262253-3ovqhypt	266	7	understand	understand	VB
cord-262253-3ovqhypt	266	8	why	why	WRB
cord-262253-3ovqhypt	266	9	the	the	DT
cord-262253-3ovqhypt	266	10	benefits	benefit	NNS
cord-262253-3ovqhypt	266	11	seen	see	VBN
cord-262253-3ovqhypt	266	12	in	in	IN
cord-262253-3ovqhypt	266	13	murine	murine	JJ
cord-262253-3ovqhypt	266	14	models	model	NNS
cord-262253-3ovqhypt	266	15	do	do	VBP
cord-262253-3ovqhypt	266	16	not	not	RB
cord-262253-3ovqhypt	266	17	translate	translate	VB
cord-262253-3ovqhypt	266	18	into	into	IN
cord-262253-3ovqhypt	266	19	clinical	clinical	JJ
cord-262253-3ovqhypt	266	20	trials	trial	NNS
cord-262253-3ovqhypt	266	21	.	.	.
cord-262253-3ovqhypt	267	1	Propranolol	propranolol	NN
cord-262253-3ovqhypt	267	2	hydrochloride	hydrochloride	NN
cord-262253-3ovqhypt	267	3	,	,	,
cord-262253-3ovqhypt	267	4	an	an	DT
cord-262253-3ovqhypt	267	5	antihypertensive	antihypertensive	JJ
cord-262253-3ovqhypt	267	6	drug	drug	NN
cord-262253-3ovqhypt	267	7	shown	show	VBN
cord-262253-3ovqhypt	267	8	to	to	TO
cord-262253-3ovqhypt	267	9	have	have	VB
cord-262253-3ovqhypt	267	10	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	267	11	properties	property	NNS
cord-262253-3ovqhypt	267	12	[	[	-LRB-
cord-262253-3ovqhypt	267	13	137	137	CD
cord-262253-3ovqhypt	267	14	]	]	-RRB-
cord-262253-3ovqhypt	267	15	,	,	,
cord-262253-3ovqhypt	267	16	has	have	VBZ
cord-262253-3ovqhypt	267	17	also	also	RB
cord-262253-3ovqhypt	267	18	been	be	VBN
cord-262253-3ovqhypt	267	19	found	find	VBN
cord-262253-3ovqhypt	267	20	to	to	TO
cord-262253-3ovqhypt	267	21	impact	impact	VB
cord-262253-3ovqhypt	267	22	Aβ	Aβ	NNP
cord-262253-3ovqhypt	267	23	production	production	NN
cord-262253-3ovqhypt	267	24	.	.	.
cord-262253-3ovqhypt	268	1	Cortico	cortico	NN
cord-262253-3ovqhypt	268	2	-	-	HYPH
cord-262253-3ovqhypt	268	3	hippocampal	hippocampal	JJ
cord-262253-3ovqhypt	268	4	neuronal	neuronal	JJ
cord-262253-3ovqhypt	268	5	cultures	culture	NNS
cord-262253-3ovqhypt	268	6	treated	treat	VBN
cord-262253-3ovqhypt	268	7	with	with	IN
cord-262253-3ovqhypt	268	8	this	this	DT
cord-262253-3ovqhypt	268	9	drug	drug	NN
cord-262253-3ovqhypt	268	10	manifested	manifest	VBD
cord-262253-3ovqhypt	268	11	reduced	reduced	JJ
cord-262253-3ovqhypt	268	12	levels	level	NNS
cord-262253-3ovqhypt	268	13	of	of	IN
cord-262253-3ovqhypt	268	14	Aβ	Aβ	NNP
cord-262253-3ovqhypt	268	15	production	production	NN
cord-262253-3ovqhypt	268	16	.	.	.
cord-262253-3ovqhypt	269	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	269	2	,	,	,
cord-262253-3ovqhypt	269	3	the	the	DT
cord-262253-3ovqhypt	269	4	one	one	CD
cord-262253-3ovqhypt	269	5	-	-	HYPH
cord-262253-3ovqhypt	269	6	month	month	NN
cord-262253-3ovqhypt	269	7	treatment	treatment	NN
cord-262253-3ovqhypt	269	8	of	of	IN
cord-262253-3ovqhypt	269	9	Tg2576	Tg2576	NNP
cord-262253-3ovqhypt	269	10	mice	mouse	NNS
cord-262253-3ovqhypt	269	11	resulted	result	VBD
cord-262253-3ovqhypt	269	12	in	in	IN
cord-262253-3ovqhypt	269	13	roughly	roughly	RB
cord-262253-3ovqhypt	269	14	a	a	DT
cord-262253-3ovqhypt	269	15	40	40	CD
cord-262253-3ovqhypt	269	16	%	%	NN
cord-262253-3ovqhypt	269	17	reduction	reduction	NN
cord-262253-3ovqhypt	269	18	of	of	IN
cord-262253-3ovqhypt	269	19	Aβ	Aβ	NNP
cord-262253-3ovqhypt	269	20	1	1	CD
cord-262253-3ovqhypt	269	21	-	-	SYM
cord-262253-3ovqhypt	269	22	40	40	CD
cord-262253-3ovqhypt	269	23	and	and	CC
cord-262253-3ovqhypt	269	24	Aβ	Aβ	NNP
cord-262253-3ovqhypt	269	25	1	1	CD
cord-262253-3ovqhypt	269	26	-	-	SYM
cord-262253-3ovqhypt	269	27	42	42	CD
cord-262253-3ovqhypt	269	28	levels	level	NNS
cord-262253-3ovqhypt	269	29	in	in	IN
cord-262253-3ovqhypt	269	30	the	the	DT
cord-262253-3ovqhypt	269	31	brain	brain	NN
cord-262253-3ovqhypt	269	32	.	.	.
cord-262253-3ovqhypt	270	1	When	when	WRB
cord-262253-3ovqhypt	270	2	administered	administer	VBN
cord-262253-3ovqhypt	270	3	over	over	IN
cord-262253-3ovqhypt	270	4	a	a	DT
cord-262253-3ovqhypt	270	5	period	period	NN
cord-262253-3ovqhypt	270	6	of	of	IN
cord-262253-3ovqhypt	270	7	6	6	CD
cord-262253-3ovqhypt	270	8	months	month	NNS
cord-262253-3ovqhypt	270	9	,	,	,
cord-262253-3ovqhypt	270	10	Aβ	Aβ	NNP
cord-262253-3ovqhypt	270	11	peptide	peptide	NN
cord-262253-3ovqhypt	270	12	levels	level	NNS
cord-262253-3ovqhypt	270	13	were	be	VBD
cord-262253-3ovqhypt	270	14	still	still	RB
cord-262253-3ovqhypt	270	15	reduced	reduce	VBN
cord-262253-3ovqhypt	270	16	in	in	IN
cord-262253-3ovqhypt	270	17	the	the	DT
cord-262253-3ovqhypt	270	18	brain	brain	NN
cord-262253-3ovqhypt	270	19	;	;	:
cord-262253-3ovqhypt	270	20	however	however	RB
cord-262253-3ovqhypt	270	21	,	,	,
cord-262253-3ovqhypt	270	22	no	no	DT
cord-262253-3ovqhypt	270	23	improvement	improvement	NN
cord-262253-3ovqhypt	270	24	in	in	IN
cord-262253-3ovqhypt	270	25	spatial	spatial	JJ
cord-262253-3ovqhypt	270	26	memory	memory	NN
cord-262253-3ovqhypt	270	27	function	function	NN
cord-262253-3ovqhypt	270	28	was	be	VBD
cord-262253-3ovqhypt	270	29	observed	observe	VBN
cord-262253-3ovqhypt	270	30	[	[	-LRB-
cord-262253-3ovqhypt	270	31	138	138	CD
cord-262253-3ovqhypt	270	32	]	]	-RRB-
cord-262253-3ovqhypt	270	33	.	.	.
cord-262253-3ovqhypt	271	1	Rifampicin	Rifampicin	NNP
cord-262253-3ovqhypt	271	2	is	be	VBZ
cord-262253-3ovqhypt	271	3	an	an	DT
cord-262253-3ovqhypt	271	4	antibiotic	antibiotic	NN
cord-262253-3ovqhypt	271	5	derived	derive	VBN
cord-262253-3ovqhypt	271	6	from	from	IN
cord-262253-3ovqhypt	271	7	Nocardia	Nocardia	NNP
cord-262253-3ovqhypt	271	8	mediterranei	mediterranei	NNP
cord-262253-3ovqhypt	271	9	,	,	,
cord-262253-3ovqhypt	271	10	which	which	WDT
cord-262253-3ovqhypt	271	11	has	have	VBZ
cord-262253-3ovqhypt	271	12	been	be	VBN
cord-262253-3ovqhypt	271	13	investigated	investigate	VBN
cord-262253-3ovqhypt	271	14	for	for	IN
cord-262253-3ovqhypt	271	15	use	use	NN
cord-262253-3ovqhypt	271	16	in	in	IN
cord-262253-3ovqhypt	271	17	neurodegenerative	neurodegenerative	JJ
cord-262253-3ovqhypt	271	18	diseases	disease	NNS
cord-262253-3ovqhypt	271	19	such	such	JJ
cord-262253-3ovqhypt	271	20	as	as	IN
cord-262253-3ovqhypt	271	21	Parkinson	Parkinson	NNP
cord-262253-3ovqhypt	271	22	's	's	POS
cord-262253-3ovqhypt	271	23	and	and	CC
cord-262253-3ovqhypt	271	24	AD	ad	NN
cord-262253-3ovqhypt	271	25	[	[	-LRB-
cord-262253-3ovqhypt	271	26	139	139	CD
cord-262253-3ovqhypt	271	27	,	,	,
cord-262253-3ovqhypt	271	28	140	140	CD
cord-262253-3ovqhypt	271	29	]	]	-RRB-
cord-262253-3ovqhypt	271	30	.	.	.
cord-262253-3ovqhypt	272	1	Rifampicin	Rifampicin	NNP
cord-262253-3ovqhypt	272	2	has	have	VBZ
cord-262253-3ovqhypt	272	3	been	be	VBN
cord-262253-3ovqhypt	272	4	found	find	VBN
cord-262253-3ovqhypt	272	5	to	to	TO
cord-262253-3ovqhypt	272	6	provide	provide	VB
cord-262253-3ovqhypt	272	7	neuroprotection	neuroprotection	NN
cord-262253-3ovqhypt	272	8	through	through	IN
cord-262253-3ovqhypt	272	9	its	-PRON-	PRP$
cord-262253-3ovqhypt	272	10	anti	anti	JJ
cord-262253-3ovqhypt	272	11	-	-	JJ
cord-262253-3ovqhypt	272	12	oxidant	oxidant	JJ
cord-262253-3ovqhypt	272	13	and	and	CC
cord-262253-3ovqhypt	272	14	anti	anti	JJ
cord-262253-3ovqhypt	272	15	-	-	JJ
cord-262253-3ovqhypt	272	16	inflammatory	inflammatory	JJ
cord-262253-3ovqhypt	272	17	properties	property	NNS
cord-262253-3ovqhypt	272	18	[	[	-LRB-
cord-262253-3ovqhypt	272	19	139	139	CD
cord-262253-3ovqhypt	272	20	,	,	,
cord-262253-3ovqhypt	272	21	141	141	CD
cord-262253-3ovqhypt	272	22	]	]	-RRB-
cord-262253-3ovqhypt	272	23	.	.	.
cord-262253-3ovqhypt	273	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	273	2	,	,	,
cord-262253-3ovqhypt	273	3	in	in	IN
cord-262253-3ovqhypt	273	4	vitro	vitro	FW
cord-262253-3ovqhypt	273	5	studies	study	NNS
cord-262253-3ovqhypt	273	6	found	find	VBD
cord-262253-3ovqhypt	273	7	that	that	IN
cord-262253-3ovqhypt	273	8	its	-PRON-	PRP$
cord-262253-3ovqhypt	273	9	administration	administration	NN
cord-262253-3ovqhypt	273	10	improved	improve	VBD
cord-262253-3ovqhypt	273	11	neuronal	neuronal	JJ
cord-262253-3ovqhypt	273	12	survival	survival	NN
cord-262253-3ovqhypt	273	13	and	and	CC
cord-262253-3ovqhypt	273	14	reduced	reduce	VBN
cord-262253-3ovqhypt	273	15	microglial	microglial	JJ
cord-262253-3ovqhypt	273	16	activation	activation	NN
cord-262253-3ovqhypt	273	17	[	[	-LRB-
cord-262253-3ovqhypt	273	18	141	141	CD
cord-262253-3ovqhypt	273	19	]	]	-RRB-
cord-262253-3ovqhypt	273	20	.	.	.
cord-262253-3ovqhypt	274	1	Studies	study	NNS
cord-262253-3ovqhypt	274	2	by	by	IN
cord-262253-3ovqhypt	274	3	Tomiyama	Tomiyama	NNP
cord-262253-3ovqhypt	274	4	et	et	NNP
cord-262253-3ovqhypt	274	5	al	al	NNP
cord-262253-3ovqhypt	274	6	.	.	.
cord-262253-3ovqhypt	275	1	found	find	VBD
cord-262253-3ovqhypt	275	2	rifampicin	rifampicin	NNS
cord-262253-3ovqhypt	275	3	to	to	TO
cord-262253-3ovqhypt	275	4	protect	protect	VB
cord-262253-3ovqhypt	275	5	neurons	neuron	NNS
cord-262253-3ovqhypt	275	6	from	from	IN
cord-262253-3ovqhypt	275	7	cytotoxicity	cytotoxicity	NN
cord-262253-3ovqhypt	275	8	by	by	IN
cord-262253-3ovqhypt	275	9	scavenging	scavenge	VBG
cord-262253-3ovqhypt	275	10	free	free	JJ
cord-262253-3ovqhypt	275	11	radicals	radical	NNS
cord-262253-3ovqhypt	275	12	[	[	-LRB-
cord-262253-3ovqhypt	275	13	142	142	CD
cord-262253-3ovqhypt	275	14	,	,	,
cord-262253-3ovqhypt	275	15	143	143	CD
cord-262253-3ovqhypt	275	16	]	]	-RRB-
cord-262253-3ovqhypt	275	17	.	.	.
cord-262253-3ovqhypt	276	1	In	in	IN
cord-262253-3ovqhypt	276	2	relation	relation	NN
cord-262253-3ovqhypt	276	3	to	to	IN
cord-262253-3ovqhypt	276	4	the	the	DT
cord-262253-3ovqhypt	276	5	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	276	6	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	276	7	,	,	,
cord-262253-3ovqhypt	276	8	rifampicin	rifampicin	NNP
cord-262253-3ovqhypt	276	9	has	have	VBZ
cord-262253-3ovqhypt	276	10	been	be	VBN
cord-262253-3ovqhypt	276	11	previously	previously	RB
cord-262253-3ovqhypt	276	12	studied	study	VBN
cord-262253-3ovqhypt	276	13	for	for	IN
cord-262253-3ovqhypt	276	14	use	use	NN
cord-262253-3ovqhypt	276	15	in	in	IN
cord-262253-3ovqhypt	276	16	bacterial	bacterial	JJ
cord-262253-3ovqhypt	276	17	cerebral	cerebral	JJ
cord-262253-3ovqhypt	276	18	infections	infection	NNS
cord-262253-3ovqhypt	276	19	[	[	-LRB-
cord-262253-3ovqhypt	276	20	144	144	CD
cord-262253-3ovqhypt	276	21	]	]	-RRB-
cord-262253-3ovqhypt	276	22	.	.	.
cord-262253-3ovqhypt	277	1	As	as	IN
cord-262253-3ovqhypt	277	2	rifampicin	rifampicin	NNS
cord-262253-3ovqhypt	277	3	is	be	VBZ
cord-262253-3ovqhypt	277	4	able	able	JJ
cord-262253-3ovqhypt	277	5	to	to	TO
cord-262253-3ovqhypt	277	6	cross	cross	VB
cord-262253-3ovqhypt	277	7	the	the	DT
cord-262253-3ovqhypt	277	8	BBB	BBB	NNP
cord-262253-3ovqhypt	277	9	[	[	-LRB-
cord-262253-3ovqhypt	277	10	144	144	CD
cord-262253-3ovqhypt	277	11	]	]	-RRB-
cord-262253-3ovqhypt	277	12	,	,	,
cord-262253-3ovqhypt	277	13	it	-PRON-	PRP
cord-262253-3ovqhypt	277	14	can	can	MD
cord-262253-3ovqhypt	277	15	exert	exert	VB
cord-262253-3ovqhypt	277	16	its	-PRON-	PRP$
cord-262253-3ovqhypt	277	17	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	277	18	effect	effect	NN
cord-262253-3ovqhypt	277	19	directly	directly	RB
cord-262253-3ovqhypt	277	20	in	in	IN
cord-262253-3ovqhypt	277	21	the	the	DT
cord-262253-3ovqhypt	277	22	brain	brain	NN
cord-262253-3ovqhypt	277	23	.	.	.
cord-262253-3ovqhypt	278	1	In	in	IN
cord-262253-3ovqhypt	278	2	the	the	DT
cord-262253-3ovqhypt	278	3	presence	presence	NN
cord-262253-3ovqhypt	278	4	of	of	IN
cord-262253-3ovqhypt	278	5	rifampicin	rifampicin	NNS
cord-262253-3ovqhypt	278	6	,	,	,
cord-262253-3ovqhypt	278	7	a	a	DT
cord-262253-3ovqhypt	278	8	reduction	reduction	NN
cord-262253-3ovqhypt	278	9	of	of	IN
cord-262253-3ovqhypt	278	10	Aβ	Aβ	NNP
cord-262253-3ovqhypt	278	11	fibril	fibril	NN
cord-262253-3ovqhypt	278	12	formation	formation	NN
cord-262253-3ovqhypt	278	13	[	[	-LRB-
cord-262253-3ovqhypt	278	14	142	142	CD
cord-262253-3ovqhypt	278	15	]	]	-RRB-
cord-262253-3ovqhypt	278	16	has	have	VBZ
cord-262253-3ovqhypt	278	17	been	be	VBN
cord-262253-3ovqhypt	278	18	observed	observe	VBN
cord-262253-3ovqhypt	278	19	in	in	IN
cord-262253-3ovqhypt	278	20	addition	addition	NN
cord-262253-3ovqhypt	278	21	to	to	IN
cord-262253-3ovqhypt	278	22	augmented	augment	VBN
cord-262253-3ovqhypt	278	23	Aβ	Aβ	NNP
cord-262253-3ovqhypt	278	24	clearance	clearance	NN
cord-262253-3ovqhypt	278	25	[	[	-LRB-
cord-262253-3ovqhypt	278	26	145	145	CD
cord-262253-3ovqhypt	278	27	]	]	-RRB-
cord-262253-3ovqhypt	278	28	.	.	.
cord-262253-3ovqhypt	279	1	A	a	DT
cord-262253-3ovqhypt	279	2	study	study	NN
cord-262253-3ovqhypt	279	3	by	by	IN
cord-262253-3ovqhypt	279	4	Umeda	Umeda	NNP
cord-262253-3ovqhypt	279	5	et	et	NNP
cord-262253-3ovqhypt	279	6	al	al	NNP
cord-262253-3ovqhypt	279	7	.	.	NNP
cord-262253-3ovqhypt	279	8	,	,	,
cord-262253-3ovqhypt	279	9	in	in	IN
cord-262253-3ovqhypt	279	10	which	which	WDT
cord-262253-3ovqhypt	279	11	rifampicin	rifampicin	NN
cord-262253-3ovqhypt	279	12	was	be	VBD
cord-262253-3ovqhypt	279	13	administered	administer	VBN
cord-262253-3ovqhypt	279	14	to	to	IN
cord-262253-3ovqhypt	279	15	APPOSK	APPOSK	NNP
cord-262253-3ovqhypt	279	16	mice	mouse	NNS
cord-262253-3ovqhypt	279	17	,	,	,
cord-262253-3ovqhypt	279	18	found	find	VBD
cord-262253-3ovqhypt	279	19	the	the	DT
cord-262253-3ovqhypt	279	20	treatment	treatment	NN
cord-262253-3ovqhypt	279	21	to	to	TO
cord-262253-3ovqhypt	279	22	reduce	reduce	VB
cord-262253-3ovqhypt	279	23	Aβ	Aβ	NNP
cord-262253-3ovqhypt	279	24	accumulation	accumulation	NN
cord-262253-3ovqhypt	279	25	,	,	,
cord-262253-3ovqhypt	279	26	provide	provide	VB
cord-262253-3ovqhypt	279	27	synaptic	synaptic	JJ
cord-262253-3ovqhypt	279	28	protection	protection	NN
cord-262253-3ovqhypt	279	29	,	,	,
cord-262253-3ovqhypt	279	30	and	and	CC
cord-262253-3ovqhypt	279	31	reduce	reduce	VB
cord-262253-3ovqhypt	279	32	microglial	microglial	JJ
cord-262253-3ovqhypt	279	33	activation	activation	NN
cord-262253-3ovqhypt	279	34	[	[	-LRB-
cord-262253-3ovqhypt	279	35	146	146	CD
cord-262253-3ovqhypt	279	36	]	]	-RRB-
cord-262253-3ovqhypt	279	37	.	.	.
cord-262253-3ovqhypt	280	1	Clinical	clinical	JJ
cord-262253-3ovqhypt	280	2	studies	study	NNS
cord-262253-3ovqhypt	280	3	exploring	explore	VBG
cord-262253-3ovqhypt	280	4	the	the	DT
cord-262253-3ovqhypt	280	5	impact	impact	NN
cord-262253-3ovqhypt	280	6	of	of	IN
cord-262253-3ovqhypt	280	7	rifampicin	rifampicin	NNS
cord-262253-3ovqhypt	280	8	on	on	IN
cord-262253-3ovqhypt	280	9	cognitive	cognitive	JJ
cord-262253-3ovqhypt	280	10	function	function	NN
cord-262253-3ovqhypt	280	11	have	have	VBP
cord-262253-3ovqhypt	280	12	also	also	RB
cord-262253-3ovqhypt	280	13	been	be	VBN
cord-262253-3ovqhypt	280	14	investigated	investigate	VBN
cord-262253-3ovqhypt	280	15	,	,	,
cord-262253-3ovqhypt	280	16	as	as	IN
cord-262253-3ovqhypt	280	17	mentioned	mention	VBN
cord-262253-3ovqhypt	280	18	in	in	IN
cord-262253-3ovqhypt	280	19	previous	previous	JJ
cord-262253-3ovqhypt	280	20	sections	section	NNS
cord-262253-3ovqhypt	280	21	.	.	.
cord-262253-3ovqhypt	281	1	Even	even	RB
cord-262253-3ovqhypt	281	2	with	with	IN
cord-262253-3ovqhypt	281	3	its	-PRON-	PRP$
cord-262253-3ovqhypt	281	4	many	many	JJ
cord-262253-3ovqhypt	281	5	benefits	benefit	NNS
cord-262253-3ovqhypt	281	6	,	,	,
cord-262253-3ovqhypt	281	7	the	the	DT
cord-262253-3ovqhypt	281	8	oral	oral	JJ
cord-262253-3ovqhypt	281	9	intake	intake	NN
cord-262253-3ovqhypt	281	10	of	of	IN
cord-262253-3ovqhypt	281	11	rifampicin	rifampicin	NN
cord-262253-3ovqhypt	281	12	has	have	VBZ
cord-262253-3ovqhypt	281	13	also	also	RB
cord-262253-3ovqhypt	281	14	been	be	VBN
cord-262253-3ovqhypt	281	15	associated	associate	VBN
cord-262253-3ovqhypt	281	16	with	with	IN
cord-262253-3ovqhypt	281	17	liver	liver	NN
cord-262253-3ovqhypt	281	18	injury	injury	NN
cord-262253-3ovqhypt	281	19	in	in	IN
cord-262253-3ovqhypt	281	20	humans	human	NNS
cord-262253-3ovqhypt	281	21	.	.	.
cord-262253-3ovqhypt	282	1	To	to	TO
cord-262253-3ovqhypt	282	2	circumvent	circumvent	VB
cord-262253-3ovqhypt	282	3	this	this	DT
cord-262253-3ovqhypt	282	4	limitation	limitation	NN
cord-262253-3ovqhypt	282	5	,	,	,
cord-262253-3ovqhypt	282	6	administering	administer	VBG
cord-262253-3ovqhypt	282	7	rifampicin	rifampicin	NNS
cord-262253-3ovqhypt	282	8	intranasally	intranasally	RB
cord-262253-3ovqhypt	282	9	or	or	CC
cord-262253-3ovqhypt	282	10	subcutaneously	subcutaneously	RB
cord-262253-3ovqhypt	282	11	has	have	VBZ
cord-262253-3ovqhypt	282	12	been	be	VBN
cord-262253-3ovqhypt	282	13	suggested	suggest	VBN
cord-262253-3ovqhypt	282	14	[	[	-LRB-
cord-262253-3ovqhypt	282	15	147	147	CD
cord-262253-3ovqhypt	282	16	]	]	-RRB-
cord-262253-3ovqhypt	282	17	.	.	.
cord-262253-3ovqhypt	283	1	These	these	DT
cord-262253-3ovqhypt	283	2	routes	route	NNS
cord-262253-3ovqhypt	283	3	of	of	IN
cord-262253-3ovqhypt	283	4	rifampicin	rifampicin	NNP
cord-262253-3ovqhypt	283	5	administration	administration	NN
cord-262253-3ovqhypt	283	6	have	have	VBP
cord-262253-3ovqhypt	283	7	been	be	VBN
cord-262253-3ovqhypt	283	8	shown	show	VBN
cord-262253-3ovqhypt	283	9	to	to	TO
cord-262253-3ovqhypt	283	10	be	be	VB
cord-262253-3ovqhypt	283	11	more	more	RBR
cord-262253-3ovqhypt	283	12	effective	effective	JJ
cord-262253-3ovqhypt	283	13	in	in	IN
cord-262253-3ovqhypt	283	14	improving	improve	VBG
cord-262253-3ovqhypt	283	15	memory	memory	NN
cord-262253-3ovqhypt	283	16	than	than	IN
cord-262253-3ovqhypt	283	17	oral	oral	JJ
cord-262253-3ovqhypt	283	18	administration	administration	NN
cord-262253-3ovqhypt	283	19	[	[	-LRB-
cord-262253-3ovqhypt	283	20	147	147	CD
cord-262253-3ovqhypt	283	21	]	]	-RRB-
cord-262253-3ovqhypt	283	22	.	.	.
cord-262253-3ovqhypt	284	1	The	the	DT
cord-262253-3ovqhypt	284	2	use	use	NN
cord-262253-3ovqhypt	284	3	of	of	IN
cord-262253-3ovqhypt	284	4	gingipain	gingipain	NN
cord-262253-3ovqhypt	284	5	inhibitors	inhibitor	NNS
cord-262253-3ovqhypt	284	6	in	in	IN
cord-262253-3ovqhypt	284	7	AD	ad	NN
cord-262253-3ovqhypt	284	8	is	be	VBZ
cord-262253-3ovqhypt	284	9	another	another	DT
cord-262253-3ovqhypt	284	10	approach	approach	NN
cord-262253-3ovqhypt	284	11	that	that	WDT
cord-262253-3ovqhypt	284	12	has	have	VBZ
cord-262253-3ovqhypt	284	13	been	be	VBN
cord-262253-3ovqhypt	284	14	taken	take	VBN
cord-262253-3ovqhypt	284	15	to	to	TO
cord-262253-3ovqhypt	284	16	alleviate	alleviate	VB
cord-262253-3ovqhypt	284	17	the	the	DT
cord-262253-3ovqhypt	284	18	negative	negative	JJ
cord-262253-3ovqhypt	284	19	impact	impact	NN
cord-262253-3ovqhypt	284	20	of	of	IN
cord-262253-3ovqhypt	284	21	the	the	DT
cord-262253-3ovqhypt	284	22	disease	disease	NN
cord-262253-3ovqhypt	284	23	.	.	.
cord-262253-3ovqhypt	285	1	Gingipains	gingipain	NNS
cord-262253-3ovqhypt	285	2	are	be	VBP
cord-262253-3ovqhypt	285	3	virulence	virulence	NN
cord-262253-3ovqhypt	285	4	factors	factor	NNS
cord-262253-3ovqhypt	285	5	that	that	WDT
cord-262253-3ovqhypt	285	6	are	be	VBP
cord-262253-3ovqhypt	285	7	produced	produce	VBN
cord-262253-3ovqhypt	285	8	by	by	IN
cord-262253-3ovqhypt	285	9	P.	P.	NNP
cord-262253-3ovqhypt	285	10	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	285	11	[	[	-LRB-
cord-262253-3ovqhypt	285	12	148	148	CD
cord-262253-3ovqhypt	285	13	]	]	-RRB-
cord-262253-3ovqhypt	285	14	.	.	.
cord-262253-3ovqhypt	286	1	They	-PRON-	PRP
cord-262253-3ovqhypt	286	2	are	be	VBP
cord-262253-3ovqhypt	286	3	made	make	VBN
cord-262253-3ovqhypt	286	4	up	up	RP
cord-262253-3ovqhypt	286	5	of	of	IN
cord-262253-3ovqhypt	286	6	a	a	DT
cord-262253-3ovqhypt	286	7	group	group	NN
cord-262253-3ovqhypt	286	8	of	of	IN
cord-262253-3ovqhypt	286	9	cysteine	cysteine	NN
cord-262253-3ovqhypt	286	10	proteinases	proteinase	NNS
cord-262253-3ovqhypt	286	11	,	,	,
cord-262253-3ovqhypt	286	12	specifically	specifically	RB
cord-262253-3ovqhypt	286	13	arginin	arginin	NNP
cord-262253-3ovqhypt	286	14	-	-	HYPH
cord-262253-3ovqhypt	286	15	gingipain	gingipain	NNP
cord-262253-3ovqhypt	286	16	A	A	NNP
cord-262253-3ovqhypt	286	17	,	,	,
cord-262253-3ovqhypt	286	18	arginine	arginine	NN
cord-262253-3ovqhypt	286	19	-	-	HYPH
cord-262253-3ovqhypt	286	20	gingipain	gingipain	NNP
cord-262253-3ovqhypt	286	21	B	b	NN
cord-262253-3ovqhypt	286	22	,	,	,
cord-262253-3ovqhypt	286	23	and	and	CC
cord-262253-3ovqhypt	286	24	lysign	lysign	NN
cord-262253-3ovqhypt	286	25	-	-	HYPH
cord-262253-3ovqhypt	286	26	gingipain	gingipain	NNP
cord-262253-3ovqhypt	286	27	[	[	-LRB-
cord-262253-3ovqhypt	286	28	148	148	CD
cord-262253-3ovqhypt	286	29	,	,	,
cord-262253-3ovqhypt	286	30	149	149	CD
cord-262253-3ovqhypt	286	31	]	]	-RRB-
cord-262253-3ovqhypt	286	32	.	.	.
cord-262253-3ovqhypt	287	1	Given	give	VBN
cord-262253-3ovqhypt	287	2	the	the	DT
cord-262253-3ovqhypt	287	3	key	key	JJ
cord-262253-3ovqhypt	287	4	role	role	NN
cord-262253-3ovqhypt	287	5	gingipains	gingipain	NNS
cord-262253-3ovqhypt	287	6	play	play	VBP
cord-262253-3ovqhypt	287	7	in	in	IN
cord-262253-3ovqhypt	287	8	host	host	NN
cord-262253-3ovqhypt	287	9	colonization	colonization	NN
cord-262253-3ovqhypt	287	10	[	[	-LRB-
cord-262253-3ovqhypt	287	11	148	148	CD
cord-262253-3ovqhypt	287	12	]	]	-RRB-
cord-262253-3ovqhypt	287	13	and	and	CC
cord-262253-3ovqhypt	287	14	the	the	DT
cord-262253-3ovqhypt	287	15	inactivation	inactivation	NN
cord-262253-3ovqhypt	287	16	of	of	IN
cord-262253-3ovqhypt	287	17	host	host	NN
cord-262253-3ovqhypt	287	18	defenses	defense	NNS
cord-262253-3ovqhypt	287	19	[	[	-LRB-
cord-262253-3ovqhypt	287	20	150	150	CD
cord-262253-3ovqhypt	287	21	]	]	-RRB-
cord-262253-3ovqhypt	287	22	[	[	-LRB-
cord-262253-3ovqhypt	287	23	151	151	CD
cord-262253-3ovqhypt	287	24	]	]	-RRB-
cord-262253-3ovqhypt	287	25	[	[	-LRB-
cord-262253-3ovqhypt	287	26	152	152	CD
cord-262253-3ovqhypt	287	27	]	]	-RRB-
cord-262253-3ovqhypt	287	28	,	,	,
cord-262253-3ovqhypt	287	29	they	-PRON-	PRP
cord-262253-3ovqhypt	287	30	are	be	VBP
cord-262253-3ovqhypt	287	31	essential	essential	JJ
cord-262253-3ovqhypt	287	32	for	for	IN
cord-262253-3ovqhypt	287	33	the	the	DT
cord-262253-3ovqhypt	287	34	survival	survival	NN
cord-262253-3ovqhypt	287	35	and	and	CC
cord-262253-3ovqhypt	287	36	pathogenicity	pathogenicity	NN
cord-262253-3ovqhypt	287	37	of	of	IN
cord-262253-3ovqhypt	287	38	P.	P.	NNP
cord-262253-3ovqhypt	287	39	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	287	40	.	.	.
cord-262253-3ovqhypt	288	1	Regarding	regard	VBG
cord-262253-3ovqhypt	288	2	Aβ	Aβ	NNP
cord-262253-3ovqhypt	288	3	1	1	CD
cord-262253-3ovqhypt	288	4	-	-	SYM
cord-262253-3ovqhypt	288	5	42	42	CD
cord-262253-3ovqhypt	288	6	peptide	peptide	NN
cord-262253-3ovqhypt	288	7	production	production	NN
cord-262253-3ovqhypt	288	8	,	,	,
cord-262253-3ovqhypt	288	9	P.	P.	NNP
cord-262253-3ovqhypt	288	10	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	288	11	infection	infection	NN
cord-262253-3ovqhypt	288	12	was	be	VBD
cord-262253-3ovqhypt	288	13	found	find	VBN
cord-262253-3ovqhypt	288	14	to	to	TO
cord-262253-3ovqhypt	288	15	increase	increase	VB
cord-262253-3ovqhypt	288	16	Aβ	Aβ	NNP
cord-262253-3ovqhypt	288	17	1	1	CD
cord-262253-3ovqhypt	288	18	-	-	SYM
cord-262253-3ovqhypt	288	19	42	42	CD
cord-262253-3ovqhypt	288	20	levels	level	NNS
cord-262253-3ovqhypt	288	21	.	.	.
cord-262253-3ovqhypt	289	1	Furthermore	furthermore	RB
cord-262253-3ovqhypt	289	2	,	,	,
cord-262253-3ovqhypt	289	3	incubating	incubate	VBG
cord-262253-3ovqhypt	289	4	P.	p.	NN
cord-262253-3ovqhypt	289	5	gingivalis	gingivali	NNS
cord-262253-3ovqhypt	289	6	with	with	IN
cord-262253-3ovqhypt	289	7	Aβ	Aβ	NNP
cord-262253-3ovqhypt	289	8	1	1	CD
cord-262253-3ovqhypt	289	9	-	-	SYM
cord-262253-3ovqhypt	289	10	42	42	CD
cord-262253-3ovqhypt	289	11	peptides	peptide	NNS
cord-262253-3ovqhypt	289	12	led	lead	VBD
cord-262253-3ovqhypt	289	13	to	to	IN
cord-262253-3ovqhypt	289	14	a	a	DT
cord-262253-3ovqhypt	289	15	significant	significant	JJ
cord-262253-3ovqhypt	289	16	increase	increase	NN
cord-262253-3ovqhypt	289	17	in	in	IN
cord-262253-3ovqhypt	289	18	P.	P.	NNP
cord-262253-3ovqhypt	289	19	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	289	20	death	death	NN
cord-262253-3ovqhypt	289	21	.	.	.
cord-262253-3ovqhypt	290	1	These	these	DT
cord-262253-3ovqhypt	290	2	two	two	CD
cord-262253-3ovqhypt	290	3	findings	finding	NNS
cord-262253-3ovqhypt	290	4	further	far	RBR
cord-262253-3ovqhypt	290	5	support	support	VBP
cord-262253-3ovqhypt	290	6	the	the	DT
cord-262253-3ovqhypt	290	7	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	290	8	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	290	9	for	for	IN
cord-262253-3ovqhypt	290	10	Aβ	Aβ	NNP
cord-262253-3ovqhypt	290	11	peptides	peptide	NNS
cord-262253-3ovqhypt	290	12	[	[	-LRB-
cord-262253-3ovqhypt	290	13	153	153	CD
cord-262253-3ovqhypt	290	14	]	]	-RRB-
cord-262253-3ovqhypt	290	15	.	.	.
cord-262253-3ovqhypt	291	1	Gingipain	Gingipain	NNP
cord-262253-3ovqhypt	291	2	inhibitors	inhibitor	NNS
cord-262253-3ovqhypt	291	3	,	,	,
cord-262253-3ovqhypt	291	4	such	such	JJ
cord-262253-3ovqhypt	291	5	as	as	IN
cord-262253-3ovqhypt	291	6	COR286	COR286	NNP
cord-262253-3ovqhypt	291	7	,	,	,
cord-262253-3ovqhypt	291	8	COR271	COR271	NNP
cord-262253-3ovqhypt	291	9	and	and	CC
cord-262253-3ovqhypt	291	10	COR388	COR388	NNP
cord-262253-3ovqhypt	291	11	,	,	,
cord-262253-3ovqhypt	291	12	have	have	VBP
cord-262253-3ovqhypt	291	13	been	be	VBN
cord-262253-3ovqhypt	291	14	found	find	VBN
cord-262253-3ovqhypt	291	15	to	to	TO
cord-262253-3ovqhypt	291	16	be	be	VB
cord-262253-3ovqhypt	291	17	effective	effective	JJ
cord-262253-3ovqhypt	291	18	in	in	IN
cord-262253-3ovqhypt	291	19	inducing	induce	VBG
cord-262253-3ovqhypt	291	20	P.	P.	NNP
cord-262253-3ovqhypt	291	21	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	291	22	death	death	NN
cord-262253-3ovqhypt	291	23	and	and	CC
cord-262253-3ovqhypt	291	24	reducing	reduce	VBG
cord-262253-3ovqhypt	291	25	the	the	DT
cord-262253-3ovqhypt	291	26	bacterial	bacterial	JJ
cord-262253-3ovqhypt	291	27	load	load	NN
cord-262253-3ovqhypt	291	28	in	in	IN
cord-262253-3ovqhypt	291	29	the	the	DT
cord-262253-3ovqhypt	291	30	brain	brain	NN
cord-262253-3ovqhypt	291	31	,	,	,
cord-262253-3ovqhypt	291	32	more	more	RBR
cord-262253-3ovqhypt	291	33	so	so	RB
cord-262253-3ovqhypt	291	34	than	than	IN
cord-262253-3ovqhypt	291	35	other	other	JJ
cord-262253-3ovqhypt	291	36	antibiotics	antibiotic	NNS
cord-262253-3ovqhypt	291	37	,	,	,
cord-262253-3ovqhypt	291	38	such	such	JJ
cord-262253-3ovqhypt	291	39	as	as	IN
cord-262253-3ovqhypt	291	40	moxifloxacin	moxifloxacin	NNS
cord-262253-3ovqhypt	291	41	[	[	-LRB-
cord-262253-3ovqhypt	291	42	153	153	CD
cord-262253-3ovqhypt	291	43	,	,	,
cord-262253-3ovqhypt	291	44	154	154	CD
cord-262253-3ovqhypt	291	45	]	]	-RRB-
cord-262253-3ovqhypt	291	46	.	.	.
cord-262253-3ovqhypt	292	1	In	in	IN
cord-262253-3ovqhypt	292	2	addition	addition	NN
cord-262253-3ovqhypt	292	3	,	,	,
cord-262253-3ovqhypt	292	4	COR271	COR271	NNP
cord-262253-3ovqhypt	292	5	was	be	VBD
cord-262253-3ovqhypt	292	6	found	find	VBN
cord-262253-3ovqhypt	292	7	to	to	TO
cord-262253-3ovqhypt	292	8	provide	provide	VB
cord-262253-3ovqhypt	292	9	some	some	DT
cord-262253-3ovqhypt	292	10	level	level	NN
cord-262253-3ovqhypt	292	11	of	of	IN
cord-262253-3ovqhypt	292	12	neuroprotection	neuroprotection	NN
cord-262253-3ovqhypt	292	13	as	as	RB
cord-262253-3ovqhypt	292	14	well	well	RB
cord-262253-3ovqhypt	292	15	[	[	-LRB-
cord-262253-3ovqhypt	292	16	153	153	CD
cord-262253-3ovqhypt	292	17	]	]	-RRB-
cord-262253-3ovqhypt	292	18	.	.	.
cord-262253-3ovqhypt	293	1	The	the	DT
cord-262253-3ovqhypt	293	2	administration	administration	NN
cord-262253-3ovqhypt	293	3	of	of	IN
cord-262253-3ovqhypt	293	4	gingipain	gingipain	NNP
cord-262253-3ovqhypt	293	5	inhibitors	inhibitor	NNS
cord-262253-3ovqhypt	293	6	has	have	VBZ
cord-262253-3ovqhypt	293	7	also	also	RB
cord-262253-3ovqhypt	293	8	been	be	VBN
cord-262253-3ovqhypt	293	9	associated	associate	VBN
cord-262253-3ovqhypt	293	10	with	with	IN
cord-262253-3ovqhypt	293	11	a	a	DT
cord-262253-3ovqhypt	293	12	decrease	decrease	NN
cord-262253-3ovqhypt	293	13	in	in	IN
cord-262253-3ovqhypt	293	14	host	host	NN
cord-262253-3ovqhypt	293	15	Aβ	Aβ	NNP
cord-262253-3ovqhypt	293	16	1	1	CD
cord-262253-3ovqhypt	293	17	-	-	SYM
cord-262253-3ovqhypt	293	18	42	42	CD
cord-262253-3ovqhypt	293	19	response	response	NN
cord-262253-3ovqhypt	293	20	to	to	IN
cord-262253-3ovqhypt	293	21	P.	P.	NNP
cord-262253-3ovqhypt	293	22	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	293	23	infection	infection	NN
cord-262253-3ovqhypt	293	24	[	[	-LRB-
cord-262253-3ovqhypt	293	25	68	68	CD
cord-262253-3ovqhypt	293	26	]	]	-RRB-
cord-262253-3ovqhypt	293	27	.	.	.
cord-262253-3ovqhypt	294	1	Even	even	RB
cord-262253-3ovqhypt	294	2	with	with	IN
cord-262253-3ovqhypt	294	3	the	the	DT
cord-262253-3ovqhypt	294	4	benefits	benefit	NNS
cord-262253-3ovqhypt	294	5	associated	associate	VBN
cord-262253-3ovqhypt	294	6	with	with	IN
cord-262253-3ovqhypt	294	7	the	the	DT
cord-262253-3ovqhypt	294	8	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	294	9	and	and	CC
cord-262253-3ovqhypt	294	10	antiviral	antiviral	JJ
cord-262253-3ovqhypt	294	11	drugs	drug	NNS
cord-262253-3ovqhypt	294	12	listed	list	VBN
cord-262253-3ovqhypt	294	13	above	above	RB
cord-262253-3ovqhypt	294	14	,	,	,
cord-262253-3ovqhypt	294	15	insights	insight	NNS
cord-262253-3ovqhypt	294	16	into	into	IN
cord-262253-3ovqhypt	294	17	their	-PRON-	PRP$
cord-262253-3ovqhypt	294	18	mechanism	mechanism	NN
cord-262253-3ovqhypt	294	19	of	of	IN
cord-262253-3ovqhypt	294	20	action	action	NN
cord-262253-3ovqhypt	294	21	and	and	CC
cord-262253-3ovqhypt	294	22	their	-PRON-	PRP$
cord-262253-3ovqhypt	294	23	impact	impact	NN
cord-262253-3ovqhypt	294	24	on	on	IN
cord-262253-3ovqhypt	294	25	Aβ	Aβ	NNP
cord-262253-3ovqhypt	294	26	peptide	peptide	JJ
cord-262253-3ovqhypt	294	27	levels	level	NNS
cord-262253-3ovqhypt	294	28	are	be	VBP
cord-262253-3ovqhypt	294	29	needed	need	VBN
cord-262253-3ovqhypt	294	30	.	.	.
cord-262253-3ovqhypt	295	1	A	a	DT
cord-262253-3ovqhypt	295	2	greater	great	JJR
cord-262253-3ovqhypt	295	3	understanding	understanding	NN
cord-262253-3ovqhypt	295	4	as	as	IN
cord-262253-3ovqhypt	295	5	to	to	IN
cord-262253-3ovqhypt	295	6	whether	whether	IN
cord-262253-3ovqhypt	295	7	their	-PRON-	PRP$
cord-262253-3ovqhypt	295	8	administration	administration	NN
cord-262253-3ovqhypt	295	9	indirectly	indirectly	RB
cord-262253-3ovqhypt	295	10	reduces	reduce	VBZ
cord-262253-3ovqhypt	295	11	the	the	DT
cord-262253-3ovqhypt	295	12	presence	presence	NN
cord-262253-3ovqhypt	295	13	of	of	IN
cord-262253-3ovqhypt	295	14	Aβ	Aβ	NNP
cord-262253-3ovqhypt	295	15	peptides	peptide	NNS
cord-262253-3ovqhypt	295	16	by	by	IN
cord-262253-3ovqhypt	295	17	reducing	reduce	VBG
cord-262253-3ovqhypt	295	18	the	the	DT
cord-262253-3ovqhypt	295	19	viral	viral	JJ
cord-262253-3ovqhypt	295	20	/	/	SYM
cord-262253-3ovqhypt	295	21	bacterial	bacterial	JJ
cord-262253-3ovqhypt	295	22	load	load	NN
cord-262253-3ovqhypt	295	23	on	on	IN
cord-262253-3ovqhypt	295	24	the	the	DT
cord-262253-3ovqhypt	295	25	brain	brain	NN
cord-262253-3ovqhypt	295	26	,	,	,
cord-262253-3ovqhypt	295	27	or	or	CC
cord-262253-3ovqhypt	295	28	if	if	IN
cord-262253-3ovqhypt	295	29	they	-PRON-	PRP
cord-262253-3ovqhypt	295	30	act	act	VBP
cord-262253-3ovqhypt	295	31	directly	directly	RB
cord-262253-3ovqhypt	295	32	in	in	IN
cord-262253-3ovqhypt	295	33	reducing	reduce	VBG
cord-262253-3ovqhypt	295	34	Aβ	Aβ	NNP
cord-262253-3ovqhypt	295	35	peptides	peptide	NNS
cord-262253-3ovqhypt	295	36	level	level	NN
cord-262253-3ovqhypt	295	37	,	,	,
cord-262253-3ovqhypt	295	38	is	be	VBZ
cord-262253-3ovqhypt	295	39	needed	need	VBN
cord-262253-3ovqhypt	295	40	.	.	.
cord-262253-3ovqhypt	296	1	If	if	IN
cord-262253-3ovqhypt	296	2	it	-PRON-	PRP
cord-262253-3ovqhypt	296	3	is	be	VBZ
cord-262253-3ovqhypt	296	4	the	the	DT
cord-262253-3ovqhypt	296	5	latter	latter	JJ
cord-262253-3ovqhypt	296	6	,	,	,
cord-262253-3ovqhypt	296	7	and	and	CC
cord-262253-3ovqhypt	296	8	the	the	DT
cord-262253-3ovqhypt	296	9	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	296	10	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	296	11	for	for	IN
cord-262253-3ovqhypt	296	12	Aβ	Aβ	NNP
cord-262253-3ovqhypt	296	13	peptides	peptide	NNS
cord-262253-3ovqhypt	296	14	holds	hold	VBZ
cord-262253-3ovqhypt	296	15	true	true	JJ
cord-262253-3ovqhypt	296	16	,	,	,
cord-262253-3ovqhypt	296	17	their	-PRON-	PRP$
cord-262253-3ovqhypt	296	18	efficacy	efficacy	NN
cord-262253-3ovqhypt	296	19	might	may	MD
cord-262253-3ovqhypt	296	20	not	not	RB
cord-262253-3ovqhypt	296	21	be	be	VB
cord-262253-3ovqhypt	296	22	as	as	RB
cord-262253-3ovqhypt	296	23	positive	positive	JJ
cord-262253-3ovqhypt	296	24	as	as	IN
cord-262253-3ovqhypt	296	25	hoped	hope	VBN
cord-262253-3ovqhypt	296	26	.	.	.
cord-262253-3ovqhypt	297	1	In	in	IN
cord-262253-3ovqhypt	297	2	addition	addition	NN
cord-262253-3ovqhypt	297	3	,	,	,
cord-262253-3ovqhypt	297	4	it	-PRON-	PRP
cord-262253-3ovqhypt	297	5	is	be	VBZ
cord-262253-3ovqhypt	297	6	important	important	JJ
cord-262253-3ovqhypt	297	7	that	that	IN
cord-262253-3ovqhypt	297	8	the	the	DT
cord-262253-3ovqhypt	297	9	chosen	choose	VBN
cord-262253-3ovqhypt	297	10	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	297	11	or	or	CC
cord-262253-3ovqhypt	297	12	antiviral	antiviral	JJ
cord-262253-3ovqhypt	297	13	drug	drug	NN
cord-262253-3ovqhypt	297	14	does	do	VBZ
cord-262253-3ovqhypt	297	15	not	not	RB
cord-262253-3ovqhypt	297	16	have	have	VB
cord-262253-3ovqhypt	297	17	any	any	DT
cord-262253-3ovqhypt	297	18	adverse	adverse	JJ
cord-262253-3ovqhypt	297	19	effects	effect	NNS
cord-262253-3ovqhypt	297	20	that	that	WDT
cord-262253-3ovqhypt	297	21	could	could	MD
cord-262253-3ovqhypt	297	22	take	take	VB
cord-262253-3ovqhypt	297	23	away	away	RB
cord-262253-3ovqhypt	297	24	from	from	IN
cord-262253-3ovqhypt	297	25	its	-PRON-	PRP$
cord-262253-3ovqhypt	297	26	benefits	benefit	NNS
cord-262253-3ovqhypt	297	27	.	.	.
cord-262253-3ovqhypt	298	1	For	for	IN
cord-262253-3ovqhypt	298	2	example	example	NN
cord-262253-3ovqhypt	298	3	,	,	,
cord-262253-3ovqhypt	298	4	cefepime	cefepime	NNP
cord-262253-3ovqhypt	298	5	is	be	VBZ
cord-262253-3ovqhypt	298	6	an	an	DT
cord-262253-3ovqhypt	298	7	antibiotic	antibiotic	NN
cord-262253-3ovqhypt	298	8	that	that	WDT
cord-262253-3ovqhypt	298	9	has	have	VBZ
cord-262253-3ovqhypt	298	10	shown	show	VBN
cord-262253-3ovqhypt	298	11	to	to	TO
cord-262253-3ovqhypt	298	12	be	be	VB
cord-262253-3ovqhypt	298	13	able	able	JJ
cord-262253-3ovqhypt	298	14	to	to	TO
cord-262253-3ovqhypt	298	15	cross	cross	VB
cord-262253-3ovqhypt	298	16	the	the	DT
cord-262253-3ovqhypt	298	17	blood	blood	NN
cord-262253-3ovqhypt	298	18	-	-	HYPH
cord-262253-3ovqhypt	298	19	brain	brain	NN
cord-262253-3ovqhypt	298	20	barrier	barrier	NN
cord-262253-3ovqhypt	298	21	and	and	CC
cord-262253-3ovqhypt	298	22	cause	cause	VB
cord-262253-3ovqhypt	298	23	neurotoxic	neurotoxic	JJ
cord-262253-3ovqhypt	298	24	symptoms	symptom	NNS
cord-262253-3ovqhypt	298	25	[	[	-LRB-
cord-262253-3ovqhypt	298	26	154	154	CD
cord-262253-3ovqhypt	298	27	]	]	-RRB-
cord-262253-3ovqhypt	298	28	.	.	.
cord-262253-3ovqhypt	299	1	The	the	DT
cord-262253-3ovqhypt	299	2	findings	finding	NNS
cord-262253-3ovqhypt	299	3	of	of	IN
cord-262253-3ovqhypt	299	4	the	the	DT
cord-262253-3ovqhypt	299	5	numerous	numerous	JJ
cord-262253-3ovqhypt	299	6	studies	study	NNS
cord-262253-3ovqhypt	299	7	highlighted	highlight	VBN
cord-262253-3ovqhypt	299	8	in	in	IN
cord-262253-3ovqhypt	299	9	this	this	DT
cord-262253-3ovqhypt	299	10	review	review	NN
cord-262253-3ovqhypt	299	11	present	present	VBP
cord-262253-3ovqhypt	299	12	a	a	DT
cord-262253-3ovqhypt	299	13	clear	clear	JJ
cord-262253-3ovqhypt	299	14	indication	indication	NN
cord-262253-3ovqhypt	299	15	of	of	IN
cord-262253-3ovqhypt	299	16	the	the	DT
cord-262253-3ovqhypt	299	17	role	role	NN
cord-262253-3ovqhypt	299	18	bacteria	bacteria	NNS
cord-262253-3ovqhypt	299	19	and	and	CC
cord-262253-3ovqhypt	299	20	viruses	virus	NNS
cord-262253-3ovqhypt	299	21	can	can	MD
cord-262253-3ovqhypt	299	22	have	have	VB
cord-262253-3ovqhypt	299	23	in	in	IN
cord-262253-3ovqhypt	299	24	AD	ad	NN
cord-262253-3ovqhypt	299	25	development	development	NN
cord-262253-3ovqhypt	299	26	.	.	.
cord-262253-3ovqhypt	300	1	Even	even	RB
cord-262253-3ovqhypt	300	2	with	with	IN
cord-262253-3ovqhypt	300	3	this	this	DT
cord-262253-3ovqhypt	300	4	conclusion	conclusion	NN
cord-262253-3ovqhypt	300	5	,	,	,
cord-262253-3ovqhypt	300	6	it	-PRON-	PRP
cord-262253-3ovqhypt	300	7	is	be	VBZ
cord-262253-3ovqhypt	300	8	clear	clear	JJ
cord-262253-3ovqhypt	300	9	that	that	IN
cord-262253-3ovqhypt	300	10	a	a	DT
cord-262253-3ovqhypt	300	11	specific	specific	JJ
cord-262253-3ovqhypt	300	12	bacteria	bacteria	NNS
cord-262253-3ovqhypt	300	13	or	or	CC
cord-262253-3ovqhypt	300	14	virus	virus	NN
cord-262253-3ovqhypt	300	15	alone	alone	RB
cord-262253-3ovqhypt	300	16	is	be	VBZ
cord-262253-3ovqhypt	300	17	not	not	RB
cord-262253-3ovqhypt	300	18	responsible	responsible	JJ
cord-262253-3ovqhypt	300	19	for	for	IN
cord-262253-3ovqhypt	300	20	AD	ad	NN
cord-262253-3ovqhypt	300	21	development	development	NN
cord-262253-3ovqhypt	300	22	,	,	,
cord-262253-3ovqhypt	300	23	as	as	IN
cord-262253-3ovqhypt	300	24	no	no	DT
cord-262253-3ovqhypt	300	25	specific	specific	JJ
cord-262253-3ovqhypt	300	26	bacteria	bacteria	NNS
cord-262253-3ovqhypt	300	27	or	or	CC
cord-262253-3ovqhypt	300	28	virus	virus	NN
cord-262253-3ovqhypt	300	29	has	have	VBZ
cord-262253-3ovqhypt	300	30	been	be	VBN
cord-262253-3ovqhypt	300	31	identified	identify	VBN
cord-262253-3ovqhypt	300	32	to	to	TO
cord-262253-3ovqhypt	300	33	be	be	VB
cord-262253-3ovqhypt	300	34	universally	universally	RB
cord-262253-3ovqhypt	300	35	present	present	JJ
cord-262253-3ovqhypt	300	36	in	in	IN
cord-262253-3ovqhypt	300	37	all	all	DT
cord-262253-3ovqhypt	300	38	AD	ad	NN
cord-262253-3ovqhypt	300	39	brains	brain	NNS
cord-262253-3ovqhypt	300	40	.	.	.
cord-262253-3ovqhypt	301	1	Rather	rather	RB
cord-262253-3ovqhypt	301	2	,	,	,
cord-262253-3ovqhypt	301	3	a	a	DT
cord-262253-3ovqhypt	301	4	number	number	NN
cord-262253-3ovqhypt	301	5	of	of	IN
cord-262253-3ovqhypt	301	6	viruses	virus	NNS
cord-262253-3ovqhypt	301	7	and	and	CC
cord-262253-3ovqhypt	301	8	bacteria	bacteria	NNS
cord-262253-3ovqhypt	301	9	could	could	MD
cord-262253-3ovqhypt	301	10	exacerbate	exacerbate	VB
cord-262253-3ovqhypt	301	11	the	the	DT
cord-262253-3ovqhypt	301	12	progression	progression	NN
cord-262253-3ovqhypt	301	13	of	of	IN
cord-262253-3ovqhypt	301	14	neurodegenerative	neurodegenerative	JJ
cord-262253-3ovqhypt	301	15	diseases	disease	NNS
cord-262253-3ovqhypt	301	16	,	,	,
cord-262253-3ovqhypt	301	17	either	either	CC
cord-262253-3ovqhypt	301	18	independently	independently	RB
cord-262253-3ovqhypt	301	19	or	or	CC
cord-262253-3ovqhypt	301	20	along	along	IN
cord-262253-3ovqhypt	301	21	with	with	IN
cord-262253-3ovqhypt	301	22	other	other	JJ
cord-262253-3ovqhypt	301	23	pathogens	pathogen	NNS
cord-262253-3ovqhypt	301	24	.	.	.
cord-262253-3ovqhypt	302	1	By	by	IN
cord-262253-3ovqhypt	302	2	exploring	explore	VBG
cord-262253-3ovqhypt	302	3	the	the	DT
cord-262253-3ovqhypt	302	4	presence	presence	NN
cord-262253-3ovqhypt	302	5	of	of	IN
cord-262253-3ovqhypt	302	6	multiple	multiple	JJ
cord-262253-3ovqhypt	302	7	viruses	virus	NNS
cord-262253-3ovqhypt	302	8	/	/	SYM
cord-262253-3ovqhypt	302	9	bacteria	bacteria	NNS
cord-262253-3ovqhypt	302	10	in	in	IN
cord-262253-3ovqhypt	302	11	AD	ad	NN
cord-262253-3ovqhypt	302	12	brains	brain	NNS
cord-262253-3ovqhypt	302	13	,	,	,
cord-262253-3ovqhypt	302	14	future	future	JJ
cord-262253-3ovqhypt	302	15	investigations	investigation	NNS
cord-262253-3ovqhypt	302	16	can	can	MD
cord-262253-3ovqhypt	302	17	give	give	VB
cord-262253-3ovqhypt	302	18	insights	insight	NNS
cord-262253-3ovqhypt	302	19	into	into	IN
cord-262253-3ovqhypt	302	20	which	which	WDT
cord-262253-3ovqhypt	302	21	microorganisms	microorganism	NNS
cord-262253-3ovqhypt	302	22	are	be	VBP
cord-262253-3ovqhypt	302	23	most	most	RBS
cord-262253-3ovqhypt	302	24	present	present	JJ
cord-262253-3ovqhypt	302	25	,	,	,
cord-262253-3ovqhypt	302	26	and	and	CC
cord-262253-3ovqhypt	302	27	whether	whether	IN
cord-262253-3ovqhypt	302	28	all	all	DT
cord-262253-3ovqhypt	302	29	AD	ad	NN
cord-262253-3ovqhypt	302	30	brains	brain	NNS
cord-262253-3ovqhypt	302	31	have	have	VBP
cord-262253-3ovqhypt	302	32	both	both	CC
cord-262253-3ovqhypt	302	33	a	a	DT
cord-262253-3ovqhypt	302	34	detected	detect	VBN
cord-262253-3ovqhypt	302	35	and	and	CC
cord-262253-3ovqhypt	302	36	increased	increase	VBN
cord-262253-3ovqhypt	302	37	level	level	NN
cord-262253-3ovqhypt	302	38	of	of	IN
cord-262253-3ovqhypt	302	39	selected	select	VBN
cord-262253-3ovqhypt	302	40	bacteria	bacteria	NNS
cord-262253-3ovqhypt	302	41	/	/	SYM
cord-262253-3ovqhypt	302	42	virus	virus	NN
cord-262253-3ovqhypt	302	43	.	.	.
cord-262253-3ovqhypt	303	1	The	the	DT
cord-262253-3ovqhypt	303	2	use	use	NN
cord-262253-3ovqhypt	303	3	of	of	IN
cord-262253-3ovqhypt	303	4	antiviral	antiviral	JJ
cord-262253-3ovqhypt	303	5	and	and	CC
cord-262253-3ovqhypt	303	6	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	303	7	drugs	drug	NNS
cord-262253-3ovqhypt	303	8	early	early	RB
cord-262253-3ovqhypt	303	9	on	on	RB
cord-262253-3ovqhypt	303	10	,	,	,
cord-262253-3ovqhypt	303	11	while	while	IN
cord-262253-3ovqhypt	303	12	the	the	DT
cord-262253-3ovqhypt	303	13	patient	patient	NN
cord-262253-3ovqhypt	303	14	is	be	VBZ
cord-262253-3ovqhypt	303	15	still	still	RB
cord-262253-3ovqhypt	303	16	in	in	IN
cord-262253-3ovqhypt	303	17	the	the	DT
cord-262253-3ovqhypt	303	18	presymptomatic	presymptomatic	JJ
cord-262253-3ovqhypt	303	19	phase	phase	NN
cord-262253-3ovqhypt	303	20	of	of	IN
cord-262253-3ovqhypt	303	21	AD	ad	NN
cord-262253-3ovqhypt	303	22	,	,	,
cord-262253-3ovqhypt	303	23	could	could	MD
cord-262253-3ovqhypt	303	24	have	have	VB
cord-262253-3ovqhypt	303	25	potential	potential	JJ
cord-262253-3ovqhypt	303	26	effectiveness	effectiveness	NN
cord-262253-3ovqhypt	303	27	in	in	IN
cord-262253-3ovqhypt	303	28	targeting	target	VBG
cord-262253-3ovqhypt	303	29	the	the	DT
cord-262253-3ovqhypt	303	30	root	root	NN
cord-262253-3ovqhypt	303	31	cause	cause	NN
cord-262253-3ovqhypt	303	32	of	of	IN
cord-262253-3ovqhypt	303	33	AD	ad	NN
cord-262253-3ovqhypt	303	34	pathogenesis	pathogenesis	NN
cord-262253-3ovqhypt	303	35	and	and	CC
cord-262253-3ovqhypt	303	36	alleviating	alleviate	VBG
cord-262253-3ovqhypt	303	37	the	the	DT
cord-262253-3ovqhypt	303	38	viral	viral	JJ
cord-262253-3ovqhypt	303	39	/	/	SYM
cord-262253-3ovqhypt	303	40	microbial	microbial	JJ
cord-262253-3ovqhypt	303	41	load	load	NN
cord-262253-3ovqhypt	303	42	on	on	IN
cord-262253-3ovqhypt	303	43	the	the	DT
cord-262253-3ovqhypt	303	44	brain	brain	NN
cord-262253-3ovqhypt	303	45	.	.	.
cord-262253-3ovqhypt	304	1	Further	further	JJ
cord-262253-3ovqhypt	304	2	investigations	investigation	NNS
cord-262253-3ovqhypt	304	3	into	into	IN
cord-262253-3ovqhypt	304	4	their	-PRON-	PRP$
cord-262253-3ovqhypt	304	5	use	use	NN
cord-262253-3ovqhypt	304	6	in	in	IN
cord-262253-3ovqhypt	304	7	AD	ad	NN
cord-262253-3ovqhypt	304	8	would	would	MD
cord-262253-3ovqhypt	304	9	give	give	VB
cord-262253-3ovqhypt	304	10	greater	great	JJR
cord-262253-3ovqhypt	304	11	insight	insight	NN
cord-262253-3ovqhypt	304	12	regarding	regard	VBG
cord-262253-3ovqhypt	304	13	their	-PRON-	PRP$
cord-262253-3ovqhypt	304	14	efficacy	efficacy	NN
cord-262253-3ovqhypt	304	15	and	and	CC
cord-262253-3ovqhypt	304	16	limitations	limitation	NNS
cord-262253-3ovqhypt	304	17	.	.	.
cord-262253-3ovqhypt	305	1	Funding	funding	NN
cord-262253-3ovqhypt	305	2	:	:	:
cord-262253-3ovqhypt	306	1	This	this	DT
cord-262253-3ovqhypt	306	2	study	study	NN
cord-262253-3ovqhypt	306	3	was	be	VBD
cord-262253-3ovqhypt	306	4	supported	support	VBN
cord-262253-3ovqhypt	306	5	by	by	IN
cord-262253-3ovqhypt	306	6	the	the	DT
cord-262253-3ovqhypt	306	7	Altschul	Altschul	NNP
cord-262253-3ovqhypt	306	8	Foundation	Foundation	NNP
cord-262253-3ovqhypt	306	9	and	and	CC
cord-262253-3ovqhypt	306	10	in	in	IN
cord-262253-3ovqhypt	306	11	part	part	NN
cord-262253-3ovqhypt	306	12	by	by	IN
cord-262253-3ovqhypt	306	13	grant	grant	NN
cord-262253-3ovqhypt	306	14	number	number	NN
cord-262253-3ovqhypt	306	15	P50	P50	NNP
cord-262253-3ovqhypt	306	16	AT008661	AT008661	NNP
cord-262253-3ovqhypt	306	17	-	-	HYPH
cord-262253-3ovqhypt	306	18	01	01	CD
cord-262253-3ovqhypt	306	19	from	from	IN
cord-262253-3ovqhypt	306	20	the	the	DT
cord-262253-3ovqhypt	306	21	NCCIH	NCCIH	NNP
cord-262253-3ovqhypt	306	22	and	and	CC
cord-262253-3ovqhypt	306	23	ODS	ODS	NNP
cord-262253-3ovqhypt	306	24	.	.	.
cord-262253-3ovqhypt	307	1	We	-PRON-	PRP
cord-262253-3ovqhypt	307	2	acknowledge	acknowledge	VBP
cord-262253-3ovqhypt	307	3	that	that	IN
cord-262253-3ovqhypt	307	4	the	the	DT
cord-262253-3ovqhypt	307	5	contents	content	NNS
cord-262253-3ovqhypt	307	6	of	of	IN
cord-262253-3ovqhypt	307	7	this	this	DT
cord-262253-3ovqhypt	307	8	review	review	NN
cord-262253-3ovqhypt	307	9	do	do	VBP
cord-262253-3ovqhypt	307	10	not	not	RB
cord-262253-3ovqhypt	307	11	represent	represent	VB
cord-262253-3ovqhypt	307	12	the	the	DT
cord-262253-3ovqhypt	307	13	views	view	NNS
cord-262253-3ovqhypt	307	14	of	of	IN
cord-262253-3ovqhypt	307	15	the	the	DT
cord-262253-3ovqhypt	307	16	NCCIH	NCCIH	NNS
cord-262253-3ovqhypt	307	17	,	,	,
cord-262253-3ovqhypt	307	18	the	the	DT
cord-262253-3ovqhypt	307	19	ODS	ODS	NNP
cord-262253-3ovqhypt	307	20	,	,	,
cord-262253-3ovqhypt	307	21	the	the	DT
cord-262253-3ovqhypt	307	22	NIH	NIH	NNP
cord-262253-3ovqhypt	307	23	,	,	,
cord-262253-3ovqhypt	307	24	or	or	CC
cord-262253-3ovqhypt	307	25	the	the	DT
cord-262253-3ovqhypt	307	26	United	United	NNP
cord-262253-3ovqhypt	307	27	States	States	NNP
cord-262253-3ovqhypt	307	28	Government	Government	NNP
cord-262253-3ovqhypt	307	29	.	.	.
cord-262253-3ovqhypt	308	1	The	the	DT
cord-262253-3ovqhypt	308	2	authors	author	NNS
cord-262253-3ovqhypt	308	3	declare	declare	VBP
cord-262253-3ovqhypt	308	4	no	no	DT
cord-262253-3ovqhypt	308	5	conflict	conflict	NN
cord-262253-3ovqhypt	308	6	of	of	IN
cord-262253-3ovqhypt	308	7	interest	interest	NN
cord-262253-3ovqhypt	308	8	.	.	.
cord-262253-3ovqhypt	309	1	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	309	2	's	's	POS
cord-262253-3ovqhypt	309	3	Disease	Disease	NNP
cord-262253-3ovqhypt	310	1	Aβ	Aβ	NNP
cord-262253-3ovqhypt	311	1	amyloid	amyloid	NNP
cord-262253-3ovqhypt	311	2	-	-	HYPH
cord-262253-3ovqhypt	311	3	β	β	NN
cord-262253-3ovqhypt	311	4	AMP	AMP	NNP
cord-262253-3ovqhypt	311	5	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	311	6	peptide	peptide	NN
cord-262253-3ovqhypt	311	7	APP	app	NN
cord-262253-3ovqhypt	311	8	amyloid	amyloid	NN
cord-262253-3ovqhypt	311	9	precursor	precursor	NN
cord-262253-3ovqhypt	311	10	proteins	protein	NNS
cord-262253-3ovqhypt	312	1	BACE1	BACE1	NNP
cord-262253-3ovqhypt	313	1	B	b	NN
cord-262253-3ovqhypt	313	2	-	-	HYPH
cord-262253-3ovqhypt	313	3	site	site	NN
cord-262253-3ovqhypt	313	4	ABPP	ABPP	NNP
cord-262253-3ovqhypt	313	5	cleaving	cleave	VBG
cord-262253-3ovqhypt	313	6	enzyme	enzyme	NN
cord-262253-3ovqhypt	314	1	BBB	BBB	NNP
cord-262253-3ovqhypt	314	2	blood	blood	NN
cord-262253-3ovqhypt	314	3	brain	brain	NN
cord-262253-3ovqhypt	314	4	barrier	barrier	NN
cord-262253-3ovqhypt	314	5	CNS	CNS	NNP
cord-262253-3ovqhypt	314	6	central	central	JJ
cord-262253-3ovqhypt	314	7	nervous	nervous	JJ
cord-262253-3ovqhypt	314	8	system	system	NN
cord-262253-3ovqhypt	314	9	HSV-1	hsv-1	VBP
cord-262253-3ovqhypt	314	10	herpes	herpes	NN
cord-262253-3ovqhypt	314	11	simplex	simplex	NN
cord-262253-3ovqhypt	314	12	virus-1	virus-1	NN
cord-262253-3ovqhypt	314	13	MBP-1	MBP-1	NNP
cord-262253-3ovqhypt	315	1	major	major	JJ
cord-262253-3ovqhypt	315	2	basic	basic	JJ
cord-262253-3ovqhypt	315	3	protein-1	protein-1	NNP
cord-262253-3ovqhypt	315	4	NFTS	NFTS	NNP
cord-262253-3ovqhypt	315	5	neurofibrillary	neurofibrillary	JJ
cord-262253-3ovqhypt	315	6	tangles	tangle	VBZ
cord-262253-3ovqhypt	315	7	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	315	8	's	's	POS
cord-262253-3ovqhypt	315	9	Disease	Disease	NNP
cord-262253-3ovqhypt	315	10	Facts	Facts	NNPS
cord-262253-3ovqhypt	315	11	and	and	CC
cord-262253-3ovqhypt	315	12	Figures	Figures	NNPS
cord-262253-3ovqhypt	315	13	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	315	14	's	's	POS
cord-262253-3ovqhypt	315	15	disease	disease	NN
cord-262253-3ovqhypt	316	1	Amyloid	amyloid	JJ
cord-262253-3ovqhypt	316	2	deposition	deposition	NN
cord-262253-3ovqhypt	316	3	as	as	IN
cord-262253-3ovqhypt	316	4	the	the	DT
cord-262253-3ovqhypt	316	5	central	central	JJ
cord-262253-3ovqhypt	316	6	event	event	NN
cord-262253-3ovqhypt	316	7	in	in	IN
cord-262253-3ovqhypt	316	8	the	the	DT
cord-262253-3ovqhypt	316	9	aetiology	aetiology	NN
cord-262253-3ovqhypt	316	10	of	of	IN
cord-262253-3ovqhypt	316	11	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	316	12	's	's	POS
cord-262253-3ovqhypt	316	13	disease	disease	NN
cord-262253-3ovqhypt	316	14	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	316	15	's	's	POS
cord-262253-3ovqhypt	316	16	disease	disease	NN
cord-262253-3ovqhypt	316	17	:	:	:
cord-262253-3ovqhypt	317	1	The	the	DT
cord-262253-3ovqhypt	317	2	amyloid	amyloid	NN
cord-262253-3ovqhypt	317	3	cascade	cascade	NN
cord-262253-3ovqhypt	317	4	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	317	5	New	New	NNP
cord-262253-3ovqhypt	317	6	α	α	NN
cord-262253-3ovqhypt	317	7	-	-	:
cord-262253-3ovqhypt	317	8	and	and	CC
cord-262253-3ovqhypt	317	9	γ	γ	NNP
cord-262253-3ovqhypt	317	10	-	-	HYPH
cord-262253-3ovqhypt	317	11	synuclein	synuclein	NNP
cord-262253-3ovqhypt	317	12	immunopathological	immunopathological	NNP
cord-262253-3ovqhypt	317	13	lesions	lesion	NNS
cord-262253-3ovqhypt	317	14	in	in	IN
cord-262253-3ovqhypt	317	15	human	human	JJ
cord-262253-3ovqhypt	317	16	brain	brain	NN
cord-262253-3ovqhypt	317	17	Neuronal	neuronal	JJ
cord-262253-3ovqhypt	317	18	loss	loss	NN
cord-262253-3ovqhypt	317	19	correlates	correlate	VBZ
cord-262253-3ovqhypt	317	20	with	with	IN
cord-262253-3ovqhypt	317	21	but	but	CC
cord-262253-3ovqhypt	317	22	exceeds	exceed	VBZ
cord-262253-3ovqhypt	317	23	neurofibrillary	neurofibrillary	JJ
cord-262253-3ovqhypt	317	24	tangles	tangle	NNS
cord-262253-3ovqhypt	317	25	in	in	IN
cord-262253-3ovqhypt	317	26	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	317	27	's	's	POS
cord-262253-3ovqhypt	317	28	disease	disease	NN
cord-262253-3ovqhypt	317	29	Correlation	correlation	NN
cord-262253-3ovqhypt	317	30	of	of	IN
cord-262253-3ovqhypt	317	31	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	317	32	disease	disease	NN
cord-262253-3ovqhypt	317	33	neuropathologic	neuropathologic	JJ
cord-262253-3ovqhypt	317	34	changes	change	NNS
cord-262253-3ovqhypt	317	35	with	with	IN
cord-262253-3ovqhypt	317	36	cognitive	cognitive	JJ
cord-262253-3ovqhypt	317	37	status	status	NN
cord-262253-3ovqhypt	317	38	:	:	:
cord-262253-3ovqhypt	318	1	A	a	DT
cord-262253-3ovqhypt	318	2	review	review	NN
cord-262253-3ovqhypt	318	3	of	of	IN
cord-262253-3ovqhypt	318	4	the	the	DT
cord-262253-3ovqhypt	318	5	literature	literature	NN
cord-262253-3ovqhypt	318	6	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	318	7	disease	disease	NN
cord-262253-3ovqhypt	318	8	therapy	therapy	NN
cord-262253-3ovqhypt	318	9	-	-	HYPH
cord-262253-3ovqhypt	318	10	moving	move	VBG
cord-262253-3ovqhypt	318	11	from	from	IN
cord-262253-3ovqhypt	318	12	amyloid	amyloid	NN
cord-262253-3ovqhypt	318	13	-	-	HYPH
cord-262253-3ovqhypt	318	14	β	β	NN
cord-262253-3ovqhypt	318	15	to	to	IN
cord-262253-3ovqhypt	318	16	tau	tau	NNP
cord-262253-3ovqhypt	319	1	The	the	DT
cord-262253-3ovqhypt	319	2	amyloid	amyloid	NN
cord-262253-3ovqhypt	319	3	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	319	4	of	of	IN
cord-262253-3ovqhypt	319	5	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	319	6	's	's	POS
cord-262253-3ovqhypt	319	7	disease	disease	NN
cord-262253-3ovqhypt	319	8	:	:	:
cord-262253-3ovqhypt	319	9	Progress	progress	NN
cord-262253-3ovqhypt	319	10	and	and	CC
cord-262253-3ovqhypt	319	11	problems	problem	NNS
cord-262253-3ovqhypt	319	12	on	on	IN
cord-262253-3ovqhypt	319	13	the	the	DT
cord-262253-3ovqhypt	319	14	road	road	NN
cord-262253-3ovqhypt	319	15	to	to	IN
cord-262253-3ovqhypt	319	16	therapeutics	therapeutic	NNS
cord-262253-3ovqhypt	319	17	neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	319	18	,	,	,
cord-262253-3ovqhypt	319	19	and	and	CC
cord-262253-3ovqhypt	319	20	beta	beta	NN
cord-262253-3ovqhypt	319	21	-	-	HYPH
cord-262253-3ovqhypt	319	22	amyloid	amyloid	NN
cord-262253-3ovqhypt	319	23	protein	protein	NN
cord-262253-3ovqhypt	319	24	in	in	IN
cord-262253-3ovqhypt	319	25	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	319	26	's	's	POS
cord-262253-3ovqhypt	319	27	disease	disease	NN
cord-262253-3ovqhypt	320	1	A	a	DT
cord-262253-3ovqhypt	320	2	critical	critical	JJ
cord-262253-3ovqhypt	320	3	appraisal	appraisal	NN
cord-262253-3ovqhypt	320	4	of	of	IN
cord-262253-3ovqhypt	320	5	amyloid	amyloid	NN
cord-262253-3ovqhypt	320	6	-	-	HYPH
cord-262253-3ovqhypt	320	7	beta	beta	NN
cord-262253-3ovqhypt	320	8	-	-	HYPH
cord-262253-3ovqhypt	320	9	targeting	target	VBG
cord-262253-3ovqhypt	320	10	therapies	therapy	NNS
cord-262253-3ovqhypt	320	11	for	for	IN
cord-262253-3ovqhypt	320	12	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	320	13	disease	disease	NN
cord-262253-3ovqhypt	320	14	Amyloid	amyloid	NN
cord-262253-3ovqhypt	320	15	-	-	HYPH
cord-262253-3ovqhypt	320	16	beta	beta	NN
cord-262253-3ovqhypt	320	17	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	320	18	targets	target	NNS
cord-262253-3ovqhypt	320	19	-	-	HYPH
cord-262253-3ovqhypt	320	20	protein	protein	NN
cord-262253-3ovqhypt	320	21	processing	processing	NN
cord-262253-3ovqhypt	320	22	,	,	,
cord-262253-3ovqhypt	320	23	lipid	lipid	NN
cord-262253-3ovqhypt	320	24	rafts	raft	NNS
cord-262253-3ovqhypt	320	25	,	,	,
cord-262253-3ovqhypt	320	26	and	and	CC
cord-262253-3ovqhypt	320	27	amyloid	amyloid	NN
cord-262253-3ovqhypt	320	28	-	-	HYPH
cord-262253-3ovqhypt	320	29	beta	beta	NN
cord-262253-3ovqhypt	320	30	pores	pore	VBZ
cord-262253-3ovqhypt	320	31	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	320	32	's	's	POS
cord-262253-3ovqhypt	320	33	disease	disease	NN
cord-262253-3ovqhypt	320	34	and	and	CC
cord-262253-3ovqhypt	320	35	the	the	DT
cord-262253-3ovqhypt	320	36	amyloid	amyloid	NN
cord-262253-3ovqhypt	320	37	-	-	HYPH
cord-262253-3ovqhypt	320	38	beta	beta	NN
cord-262253-3ovqhypt	320	39	peptide	peptide	NN
cord-262253-3ovqhypt	320	40	Regulation	regulation	NN
cord-262253-3ovqhypt	320	41	of	of	IN
cord-262253-3ovqhypt	320	42	APP	app	NN
cord-262253-3ovqhypt	320	43	cleavage	cleavage	NN
cord-262253-3ovqhypt	320	44	by	by	IN
cord-262253-3ovqhypt	320	45	alpha-	alpha-	NN
cord-262253-3ovqhypt	320	46	,	,	,
cord-262253-3ovqhypt	320	47	beta	beta	NN
cord-262253-3ovqhypt	320	48	-	-	HYPH
cord-262253-3ovqhypt	320	49	and	and	CC
cord-262253-3ovqhypt	320	50	gamma	gamma	NN
cord-262253-3ovqhypt	320	51	-	-	HYPH
cord-262253-3ovqhypt	320	52	secretases	secretase	NNS
cord-262253-3ovqhypt	321	1	Amyloid	amyloid	NN
cord-262253-3ovqhypt	321	2	beta	beta	NN
cord-262253-3ovqhypt	321	3	:	:	:
cord-262253-3ovqhypt	322	1	Structure	structure	NN
cord-262253-3ovqhypt	322	2	,	,	,
cord-262253-3ovqhypt	322	3	biology	biology	NN
cord-262253-3ovqhypt	322	4	and	and	CC
cord-262253-3ovqhypt	322	5	structure	structure	NN
cord-262253-3ovqhypt	322	6	-	-	HYPH
cord-262253-3ovqhypt	322	7	based	base	VBN
cord-262253-3ovqhypt	322	8	therapeutic	therapeutic	JJ
cord-262253-3ovqhypt	322	9	development	development	NN
cord-262253-3ovqhypt	322	10	Amyloid	amyloid	NN
cord-262253-3ovqhypt	322	11	beta	beta	NN
cord-262253-3ovqhypt	322	12	protein	protein	NN
cord-262253-3ovqhypt	322	13	(	(	-LRB-
cord-262253-3ovqhypt	322	14	A	a	DT
cord-262253-3ovqhypt	322	15	beta	beta	NN
cord-262253-3ovqhypt	322	16	)	)	-RRB-
cord-262253-3ovqhypt	322	17	in	in	IN
cord-262253-3ovqhypt	322	18	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	322	19	's	's	POS
cord-262253-3ovqhypt	322	20	disease	disease	NN
cord-262253-3ovqhypt	322	21	brain	brain	NN
cord-262253-3ovqhypt	322	22	.	.	.
cord-262253-3ovqhypt	323	1	Biochemical	biochemical	JJ
cord-262253-3ovqhypt	323	2	and	and	CC
cord-262253-3ovqhypt	323	3	immunocytochemical	immunocytochemical	JJ
cord-262253-3ovqhypt	323	4	analysis	analysis	NN
cord-262253-3ovqhypt	323	5	with	with	IN
cord-262253-3ovqhypt	323	6	antibodies	antibody	NNS
cord-262253-3ovqhypt	323	7	specific	specific	JJ
cord-262253-3ovqhypt	323	8	for	for	IN
cord-262253-3ovqhypt	323	9	forms	form	NNS
cord-262253-3ovqhypt	323	10	ending	end	VBG
cord-262253-3ovqhypt	323	11	at	at	IN
cord-262253-3ovqhypt	323	12	A	a	DT
cord-262253-3ovqhypt	323	13	beta	beta	NN
cord-262253-3ovqhypt	323	14	40	40	CD
cord-262253-3ovqhypt	323	15	or	or	CC
cord-262253-3ovqhypt	323	16	A	a	DT
cord-262253-3ovqhypt	323	17	beta	beta	NN
cord-262253-3ovqhypt	323	18	42(43	42(43	CD
cord-262253-3ovqhypt	323	19	)	)	-RRB-
cord-262253-3ovqhypt	323	20	Abeta42	Abeta42	NNP
cord-262253-3ovqhypt	323	21	is	be	VBZ
cord-262253-3ovqhypt	323	22	essential	essential	JJ
cord-262253-3ovqhypt	323	23	for	for	IN
cord-262253-3ovqhypt	323	24	parenchymal	parenchymal	JJ
cord-262253-3ovqhypt	323	25	and	and	CC
cord-262253-3ovqhypt	323	26	vascular	vascular	JJ
cord-262253-3ovqhypt	323	27	amyloid	amyloid	NN
cord-262253-3ovqhypt	323	28	deposition	deposition	NN
cord-262253-3ovqhypt	323	29	in	in	IN
cord-262253-3ovqhypt	323	30	mice	mouse	NNS
cord-262253-3ovqhypt	324	1	Abeta40	Abeta40	NNP
cord-262253-3ovqhypt	324	2	inhibits	inhibit	VBZ
cord-262253-3ovqhypt	324	3	amyloid	amyloid	JJ
cord-262253-3ovqhypt	324	4	deposition	deposition	NN
cord-262253-3ovqhypt	324	5	in	in	IN
cord-262253-3ovqhypt	324	6	vivo	vivo	NNP
cord-262253-3ovqhypt	324	7	Subacute	Subacute	NNP
cord-262253-3ovqhypt	324	8	meningoencephalitis	meningoencephalitis	NN
cord-262253-3ovqhypt	324	9	in	in	IN
cord-262253-3ovqhypt	324	10	a	a	DT
cord-262253-3ovqhypt	324	11	subset	subset	NN
cord-262253-3ovqhypt	324	12	of	of	IN
cord-262253-3ovqhypt	324	13	patients	patient	NNS
cord-262253-3ovqhypt	324	14	with	with	IN
cord-262253-3ovqhypt	324	15	AD	ad	NN
cord-262253-3ovqhypt	324	16	after	after	IN
cord-262253-3ovqhypt	324	17	Abeta42	Abeta42	NNP
cord-262253-3ovqhypt	324	18	immunization	immunization	NN
cord-262253-3ovqhypt	324	19	Clinical	clinical	JJ
cord-262253-3ovqhypt	324	20	effects	effect	NNS
cord-262253-3ovqhypt	324	21	of	of	IN
cord-262253-3ovqhypt	324	22	Abeta	Abeta	NNP
cord-262253-3ovqhypt	324	23	immunization	immunization	NN
cord-262253-3ovqhypt	324	24	(	(	-LRB-
cord-262253-3ovqhypt	324	25	AN1792	an1792	RB
cord-262253-3ovqhypt	324	26	)	)	-RRB-
cord-262253-3ovqhypt	324	27	in	in	IN
cord-262253-3ovqhypt	324	28	patients	patient	NNS
cord-262253-3ovqhypt	324	29	with	with	IN
cord-262253-3ovqhypt	324	30	AD	ad	NN
cord-262253-3ovqhypt	324	31	in	in	IN
cord-262253-3ovqhypt	324	32	an	an	DT
cord-262253-3ovqhypt	324	33	interrupted	interrupted	JJ
cord-262253-3ovqhypt	324	34	trial	trial	NN
cord-262253-3ovqhypt	324	35	A	a	DT
cord-262253-3ovqhypt	324	36	subset	subset	NN
cord-262253-3ovqhypt	324	37	of	of	IN
cord-262253-3ovqhypt	324	38	NSAIDs	nsaids	JJ
cord-262253-3ovqhypt	324	39	lower	low	JJR
cord-262253-3ovqhypt	324	40	amyloidogenic	amyloidogenic	NNP
cord-262253-3ovqhypt	324	41	Abeta42	Abeta42	NNP
cord-262253-3ovqhypt	325	1	independently	independently	RB
cord-262253-3ovqhypt	325	2	of	of	IN
cord-262253-3ovqhypt	325	3	cyclooxygenase	cyclooxygenase	NN
cord-262253-3ovqhypt	325	4	activity	activity	NN
cord-262253-3ovqhypt	325	5	Substrate	substrate	NN
cord-262253-3ovqhypt	325	6	-	-	HYPH
cord-262253-3ovqhypt	325	7	targeting	target	VBG
cord-262253-3ovqhypt	325	8	gamma	gamma	NN
cord-262253-3ovqhypt	325	9	-	-	HYPH
cord-262253-3ovqhypt	325	10	secretase	secretase	NN
cord-262253-3ovqhypt	325	11	modulators	modulator	NNS
cord-262253-3ovqhypt	325	12	Effect	Effect	NNP
cord-262253-3ovqhypt	325	13	of	of	IN
cord-262253-3ovqhypt	325	14	tarenflurbil	tarenflurbil	NNP
cord-262253-3ovqhypt	325	15	on	on	IN
cord-262253-3ovqhypt	325	16	cognitive	cognitive	JJ
cord-262253-3ovqhypt	325	17	decline	decline	NN
cord-262253-3ovqhypt	325	18	and	and	CC
cord-262253-3ovqhypt	325	19	activities	activity	NNS
cord-262253-3ovqhypt	325	20	of	of	IN
cord-262253-3ovqhypt	325	21	daily	daily	JJ
cord-262253-3ovqhypt	325	22	living	live	VBG
cord-262253-3ovqhypt	325	23	in	in	IN
cord-262253-3ovqhypt	325	24	patients	patient	NNS
cord-262253-3ovqhypt	325	25	with	with	IN
cord-262253-3ovqhypt	325	26	mild	mild	JJ
cord-262253-3ovqhypt	325	27	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	325	28	disease	disease	NN
cord-262253-3ovqhypt	325	29	:	:	:
cord-262253-3ovqhypt	326	1	A	a	DT
cord-262253-3ovqhypt	326	2	randomized	randomized	JJ
cord-262253-3ovqhypt	326	3	controlled	control	VBN
cord-262253-3ovqhypt	326	4	trial	trial	NN
cord-262253-3ovqhypt	326	5	A	a	DT
cord-262253-3ovqhypt	326	6	phase	phase	NN
cord-262253-3ovqhypt	326	7	3	3	CD
cord-262253-3ovqhypt	326	8	trial	trial	NN
cord-262253-3ovqhypt	326	9	of	of	IN
cord-262253-3ovqhypt	326	10	semagacestat	semagacestat	NN
cord-262253-3ovqhypt	326	11	for	for	IN
cord-262253-3ovqhypt	326	12	treatment	treatment	NN
cord-262253-3ovqhypt	326	13	of	of	IN
cord-262253-3ovqhypt	326	14	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	326	15	's	's	POS
cord-262253-3ovqhypt	326	16	disease	disease	NN
cord-262253-3ovqhypt	326	17	Inositol	Inositol	NNP
cord-262253-3ovqhypt	326	18	stereoisomers	stereoisomer	NNS
cord-262253-3ovqhypt	326	19	stabilize	stabilize	VBP
cord-262253-3ovqhypt	326	20	an	an	DT
cord-262253-3ovqhypt	326	21	oligomeric	oligomeric	JJ
cord-262253-3ovqhypt	326	22	aggregate	aggregate	NN
cord-262253-3ovqhypt	326	23	of	of	IN
cord-262253-3ovqhypt	326	24	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	326	25	amyloid	amyloid	NN
cord-262253-3ovqhypt	326	26	beta	beta	NN
cord-262253-3ovqhypt	326	27	peptide	peptide	NN
cord-262253-3ovqhypt	326	28	and	and	CC
cord-262253-3ovqhypt	326	29	inhibit	inhibit	VB
cord-262253-3ovqhypt	326	30	abeta	abeta	NN
cord-262253-3ovqhypt	326	31	-induced	-induce	VBN
cord-262253-3ovqhypt	326	32	toxicity	toxicity	NN
cord-262253-3ovqhypt	326	33	A	a	DT
cord-262253-3ovqhypt	326	34	phase	phase	NN
cord-262253-3ovqhypt	326	35	2	2	CD
cord-262253-3ovqhypt	326	36	randomized	randomized	JJ
cord-262253-3ovqhypt	326	37	trial	trial	NN
cord-262253-3ovqhypt	326	38	of	of	IN
cord-262253-3ovqhypt	326	39	ELND005	ELND005	NNP
cord-262253-3ovqhypt	326	40	,	,	,
cord-262253-3ovqhypt	326	41	scyllo	scyllo	NN
cord-262253-3ovqhypt	326	42	-	-	HYPH
cord-262253-3ovqhypt	326	43	inositol	inositol	NNP
cord-262253-3ovqhypt	326	44	,	,	,
cord-262253-3ovqhypt	326	45	in	in	IN
cord-262253-3ovqhypt	326	46	mild	mild	JJ
cord-262253-3ovqhypt	326	47	to	to	TO
cord-262253-3ovqhypt	326	48	moderate	moderate	JJ
cord-262253-3ovqhypt	326	49	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	326	50	disease	disease	NN
cord-262253-3ovqhypt	326	51	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	326	52	's	's	POS
cord-262253-3ovqhypt	326	53	Amyloid	Amyloid	NNP
cord-262253-3ovqhypt	326	54	-	-	HYPH
cord-262253-3ovqhypt	326	55	β	β	NNP
cord-262253-3ovqhypt	326	56	is	be	VBZ
cord-262253-3ovqhypt	326	57	an	an	DT
cord-262253-3ovqhypt	326	58	Antimicrobial	Antimicrobial	NNP
cord-262253-3ovqhypt	326	59	Peptide	Peptide	NNP
cord-262253-3ovqhypt	326	60	:	:	:
cord-262253-3ovqhypt	327	1	A	a	DT
cord-262253-3ovqhypt	327	2	Review	Review	NNP
cord-262253-3ovqhypt	327	3	of	of	IN
cord-262253-3ovqhypt	327	4	the	the	DT
cord-262253-3ovqhypt	327	5	Evidence	evidence	NN
cord-262253-3ovqhypt	327	6	Characterizing	characterize	VBG
cord-262253-3ovqhypt	327	7	the	the	DT
cord-262253-3ovqhypt	327	8	preclinical	preclinical	JJ
cord-262253-3ovqhypt	327	9	stages	stage	NNS
cord-262253-3ovqhypt	327	10	of	of	IN
cord-262253-3ovqhypt	327	11	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	327	12	's	's	POS
cord-262253-3ovqhypt	327	13	disease	disease	NN
cord-262253-3ovqhypt	327	14	and	and	CC
cord-262253-3ovqhypt	327	15	the	the	DT
cord-262253-3ovqhypt	327	16	prospect	prospect	NN
cord-262253-3ovqhypt	327	17	of	of	IN
cord-262253-3ovqhypt	327	18	presymptomatic	presymptomatic	JJ
cord-262253-3ovqhypt	327	19	intervention	intervention	NN
cord-262253-3ovqhypt	327	20	Amyloid	Amyloid	NNP
cord-262253-3ovqhypt	327	21	β	β	NNP
cord-262253-3ovqhypt	327	22	deposition	deposition	NN
cord-262253-3ovqhypt	327	23	,	,	,
cord-262253-3ovqhypt	327	24	neurodegeneration	neurodegeneration	NN
cord-262253-3ovqhypt	327	25	,	,	,
cord-262253-3ovqhypt	327	26	and	and	CC
cord-262253-3ovqhypt	327	27	cognitive	cognitive	JJ
cord-262253-3ovqhypt	327	28	decline	decline	NN
cord-262253-3ovqhypt	327	29	in	in	IN
cord-262253-3ovqhypt	327	30	sporadic	sporadic	JJ
cord-262253-3ovqhypt	327	31	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	327	32	's	's	POS
cord-262253-3ovqhypt	327	33	disease	disease	NN
cord-262253-3ovqhypt	328	1	:	:	:
cord-262253-3ovqhypt	328	2	A	a	DT
cord-262253-3ovqhypt	328	3	prospective	prospective	JJ
cord-262253-3ovqhypt	328	4	cohort	cohort	NN
cord-262253-3ovqhypt	328	5	study	study	NN
cord-262253-3ovqhypt	328	6	Blood	blood	NN
cord-262253-3ovqhypt	328	7	-	-	HYPH
cord-262253-3ovqhypt	328	8	based	base	VBN
cord-262253-3ovqhypt	328	9	biomarkers	biomarker	NNS
cord-262253-3ovqhypt	328	10	for	for	IN
cord-262253-3ovqhypt	328	11	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	328	12	disease	disease	NN
cord-262253-3ovqhypt	328	13	:	:	:
cord-262253-3ovqhypt	328	14	Mapping	map	VBG
cord-262253-3ovqhypt	328	15	the	the	DT
cord-262253-3ovqhypt	328	16	road	road	NN
cord-262253-3ovqhypt	328	17	to	to	IN
cord-262253-3ovqhypt	328	18	the	the	DT
cord-262253-3ovqhypt	328	19	clinic	clinic	NN
cord-262253-3ovqhypt	328	20	Diagnostic	Diagnostic	NNP
cord-262253-3ovqhypt	328	21	Value	Value	NNP
cord-262253-3ovqhypt	328	22	of	of	IN
cord-262253-3ovqhypt	328	23	Cerebrospinal	Cerebrospinal	NNP
cord-262253-3ovqhypt	328	24	Fluid	fluid	NN
cord-262253-3ovqhypt	328	25	Biomarkers	Biomarkers	NNPS
cord-262253-3ovqhypt	329	1	(	(	-LRB-
cord-262253-3ovqhypt	329	2	Phospho	Phospho	NNP
cord-262253-3ovqhypt	329	3	-	-	HYPH
cord-262253-3ovqhypt	329	4	Tau181	Tau181	NNP
cord-262253-3ovqhypt	329	5	,	,	,
cord-262253-3ovqhypt	329	6	total	total	JJ
cord-262253-3ovqhypt	329	7	-	-	HYPH
cord-262253-3ovqhypt	329	8	Tau	tau	NN
cord-262253-3ovqhypt	329	9	,	,	,
cord-262253-3ovqhypt	329	10	Aβ42	Aβ42	NNP
cord-262253-3ovqhypt	329	11	,	,	,
cord-262253-3ovqhypt	329	12	and	and	CC
cord-262253-3ovqhypt	329	13	Aβ40	Aβ40	NNP
cord-262253-3ovqhypt	329	14	)	)	-RRB-
cord-262253-3ovqhypt	330	1	in	in	IN
cord-262253-3ovqhypt	330	2	Prodromal	Prodromal	NNP
cord-262253-3ovqhypt	330	3	Stage	Stage	NNP
cord-262253-3ovqhypt	330	4	of	of	IN
cord-262253-3ovqhypt	330	5	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	330	6	's	's	POS
cord-262253-3ovqhypt	330	7	Disease	Disease	NNP
cord-262253-3ovqhypt	330	8	and	and	CC
cord-262253-3ovqhypt	330	9	Dementia	Dementia	NNP
cord-262253-3ovqhypt	330	10	with	with	IN
cord-262253-3ovqhypt	330	11	Lewy	Lewy	NNP
cord-262253-3ovqhypt	330	12	Bodies	Bodies	NNPS
cord-262253-3ovqhypt	330	13	Plasma	Plasma	NNP
cord-262253-3ovqhypt	330	14	β	β	NN
cord-262253-3ovqhypt	330	15	-	-	HYPH
cord-262253-3ovqhypt	330	16	amyloid	amyloid	NN
cord-262253-3ovqhypt	330	17	in	in	IN
cord-262253-3ovqhypt	330	18	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	330	19	's	's	POS
cord-262253-3ovqhypt	330	20	disease	disease	NN
cord-262253-3ovqhypt	330	21	and	and	CC
cord-262253-3ovqhypt	330	22	vascular	vascular	JJ
cord-262253-3ovqhypt	330	23	disease	disease	NN
cord-262253-3ovqhypt	330	24	Serum	serum	NN
cord-262253-3ovqhypt	330	25	neurofilament	neurofilament	NN
cord-262253-3ovqhypt	330	26	light	light	NN
cord-262253-3ovqhypt	330	27	in	in	IN
cord-262253-3ovqhypt	330	28	familial	familial	JJ
cord-262253-3ovqhypt	330	29	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	330	30	disease	disease	NN
cord-262253-3ovqhypt	330	31	:	:	:
cord-262253-3ovqhypt	330	32	A	a	DT
cord-262253-3ovqhypt	330	33	marker	marker	NN
cord-262253-3ovqhypt	330	34	of	of	IN
cord-262253-3ovqhypt	330	35	early	early	JJ
cord-262253-3ovqhypt	330	36	neurodegeneration	neurodegeneration	NN
cord-262253-3ovqhypt	330	37	Detection	detection	NN
cord-262253-3ovqhypt	330	38	of	of	IN
cord-262253-3ovqhypt	330	39	misfolded	misfolde	VBN
cord-262253-3ovqhypt	330	40	Aβ	Aβ	NNP
cord-262253-3ovqhypt	330	41	oligomers	oligomer	NNS
cord-262253-3ovqhypt	330	42	for	for	IN
cord-262253-3ovqhypt	330	43	sensitive	sensitive	JJ
cord-262253-3ovqhypt	330	44	biochemical	biochemical	JJ
cord-262253-3ovqhypt	330	45	diagnosis	diagnosis	NN
cord-262253-3ovqhypt	330	46	of	of	IN
cord-262253-3ovqhypt	330	47	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	330	48	's	's	POS
cord-262253-3ovqhypt	330	49	disease	disease	NN
cord-262253-3ovqhypt	330	50	Seeding	seed	VBG
cord-262253-3ovqhypt	330	51	selectivity	selectivity	NN
cord-262253-3ovqhypt	330	52	and	and	CC
cord-262253-3ovqhypt	330	53	ultrasensitive	ultrasensitive	JJ
cord-262253-3ovqhypt	330	54	detection	detection	NN
cord-262253-3ovqhypt	330	55	of	of	IN
cord-262253-3ovqhypt	330	56	tau	tau	NN
cord-262253-3ovqhypt	330	57	aggregate	aggregate	JJ
cord-262253-3ovqhypt	330	58	conformers	conformer	NNS
cord-262253-3ovqhypt	330	59	of	of	IN
cord-262253-3ovqhypt	330	60	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	330	61	disease	disease	NN
cord-262253-3ovqhypt	330	62	Inflammation	inflammation	NN
cord-262253-3ovqhypt	330	63	as	as	IN
cord-262253-3ovqhypt	330	64	a	a	DT
cord-262253-3ovqhypt	330	65	central	central	JJ
cord-262253-3ovqhypt	330	66	mechanism	mechanism	NN
cord-262253-3ovqhypt	330	67	in	in	IN
cord-262253-3ovqhypt	330	68	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	330	69	's	's	POS
cord-262253-3ovqhypt	330	70	disease	disease	NN
cord-262253-3ovqhypt	330	71	.	.	.
cord-262253-3ovqhypt	331	1	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	331	2	's	's	POS
cord-262253-3ovqhypt	331	3	Dement	Dement	NNP
cord-262253-3ovqhypt	331	4	Neuroinflammation	Neuroinflammation	NNP
cord-262253-3ovqhypt	332	1	:	:	:
cord-262253-3ovqhypt	332	2	The	the	DT
cord-262253-3ovqhypt	332	3	devil	devil	NN
cord-262253-3ovqhypt	332	4	is	be	VBZ
cord-262253-3ovqhypt	332	5	in	in	IN
cord-262253-3ovqhypt	332	6	the	the	DT
cord-262253-3ovqhypt	332	7	details	detail	NNS
cord-262253-3ovqhypt	332	8	An	an	DT
cord-262253-3ovqhypt	332	9	Inflammation	Inflammation	NNP
cord-262253-3ovqhypt	332	10	-	-	HYPH
cord-262253-3ovqhypt	332	11	Centric	Centric	NNP
cord-262253-3ovqhypt	332	12	View	view	NN
cord-262253-3ovqhypt	332	13	of	of	IN
cord-262253-3ovqhypt	332	14	Neurological	Neurological	NNP
cord-262253-3ovqhypt	332	15	Disease	Disease	NNP
cord-262253-3ovqhypt	332	16	:	:	:
cord-262253-3ovqhypt	332	17	Beyond	beyond	IN
cord-262253-3ovqhypt	332	18	the	the	DT
cord-262253-3ovqhypt	332	19	Neuron	Neuron	NNP
cord-262253-3ovqhypt	332	20	.	.	.
cord-262253-3ovqhypt	333	1	Front	Front	NNP
cord-262253-3ovqhypt	333	2	Alziemer	Alziemer	NNP
cord-262253-3ovqhypt	333	3	's	's	POS
cord-262253-3ovqhypt	333	4	Disease	Disease	NNP
cord-262253-3ovqhypt	333	5	and	and	CC
cord-262253-3ovqhypt	333	6	Periodontal	Periodontal	NNP
cord-262253-3ovqhypt	333	7	Disease	Disease	NNP
cord-262253-3ovqhypt	333	8	Bidirectional	bidirectional	JJ
cord-262253-3ovqhypt	333	9	Interrelationships	Interrelationships	NNPS
cord-262253-3ovqhypt	333	10	Infectious	infectious	JJ
cord-262253-3ovqhypt	333	11	immunity	immunity	NN
cord-262253-3ovqhypt	333	12	in	in	IN
cord-262253-3ovqhypt	333	13	the	the	DT
cord-262253-3ovqhypt	333	14	central	central	JJ
cord-262253-3ovqhypt	333	15	nervous	nervous	JJ
cord-262253-3ovqhypt	333	16	system	system	NN
cord-262253-3ovqhypt	333	17	and	and	CC
cord-262253-3ovqhypt	333	18	brain	brain	NN
cord-262253-3ovqhypt	333	19	function	function	NN
cord-262253-3ovqhypt	334	1	Neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	334	2	in	in	IN
cord-262253-3ovqhypt	334	3	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	334	4	's	's	POS
cord-262253-3ovqhypt	334	5	disease	disease	NN
cord-262253-3ovqhypt	334	6	:	:	:
cord-262253-3ovqhypt	334	7	Mechanisms	mechanism	NNS
cord-262253-3ovqhypt	334	8	,	,	,
cord-262253-3ovqhypt	334	9	pathologic	pathologic	JJ
cord-262253-3ovqhypt	334	10	consequences	consequence	NNS
cord-262253-3ovqhypt	334	11	,	,	,
cord-262253-3ovqhypt	334	12	and	and	CC
cord-262253-3ovqhypt	334	13	potential	potential	NN
cord-262253-3ovqhypt	334	14	for	for	IN
cord-262253-3ovqhypt	334	15	therapeutic	therapeutic	JJ
cord-262253-3ovqhypt	334	16	manipulation	manipulation	NN
cord-262253-3ovqhypt	334	17	Infectious	infectious	JJ
cord-262253-3ovqhypt	334	18	agents	agent	NNS
cord-262253-3ovqhypt	334	19	and	and	CC
cord-262253-3ovqhypt	334	20	neurodegeneration	neurodegeneration	NN
cord-262253-3ovqhypt	334	21	Role	role	NN
cord-262253-3ovqhypt	334	22	of	of	IN
cord-262253-3ovqhypt	334	23	Microbes	Microbes	NNPS
cord-262253-3ovqhypt	334	24	in	in	IN
cord-262253-3ovqhypt	334	25	the	the	DT
cord-262253-3ovqhypt	334	26	Development	Development	NNP
cord-262253-3ovqhypt	334	27	of	of	IN
cord-262253-3ovqhypt	334	28	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	334	29	's	's	POS
cord-262253-3ovqhypt	334	30	Disease	Disease	NNP
cord-262253-3ovqhypt	334	31	:	:	:
cord-262253-3ovqhypt	334	32	State	state	NN
cord-262253-3ovqhypt	334	33	of	of	IN
cord-262253-3ovqhypt	334	34	the	the	DT
cord-262253-3ovqhypt	334	35	Art	Art	NNP
cord-262253-3ovqhypt	334	36	-	-	,
cord-262253-3ovqhypt	334	37	An	An	NNP
cord-262253-3ovqhypt	334	38	International	International	NNP
cord-262253-3ovqhypt	334	39	Symposium	Symposium	NNP
cord-262253-3ovqhypt	334	40	Presented	present	VBN
cord-262253-3ovqhypt	334	41	at	at	IN
cord-262253-3ovqhypt	334	42	the	the	DT
cord-262253-3ovqhypt	334	43	2017	2017	CD
cord-262253-3ovqhypt	334	44	IAGG	IAGG	NNP
cord-262253-3ovqhypt	334	45	Congress	Congress	NNP
cord-262253-3ovqhypt	334	46	in	in	IN
cord-262253-3ovqhypt	334	47	San	San	NNP
cord-262253-3ovqhypt	334	48	Francisco	Francisco	NNP
cord-262253-3ovqhypt	334	49	Microbes	Microbes	NNPS
cord-262253-3ovqhypt	334	50	and	and	CC
cord-262253-3ovqhypt	334	51	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	334	52	's	's	POS
cord-262253-3ovqhypt	334	53	Disease	Disease	NNP
cord-262253-3ovqhypt	334	54	.	.	.
cord-262253-3ovqhypt	335	1	J.	J.	NNP
cord-262253-3ovqhypt	335	2	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	335	3	's	's	POS
cord-262253-3ovqhypt	335	4	Dis	Dis	NNP
cord-262253-3ovqhypt	335	5	Historic	historic	JJ
cord-262253-3ovqhypt	335	6	evidence	evidence	NN
cord-262253-3ovqhypt	335	7	to	to	TO
cord-262253-3ovqhypt	335	8	support	support	VB
cord-262253-3ovqhypt	335	9	a	a	DT
cord-262253-3ovqhypt	335	10	causal	causal	JJ
cord-262253-3ovqhypt	335	11	relationship	relationship	NN
cord-262253-3ovqhypt	335	12	between	between	IN
cord-262253-3ovqhypt	335	13	spirochetal	spirochetal	JJ
cord-262253-3ovqhypt	335	14	infections	infection	NNS
cord-262253-3ovqhypt	335	15	and	and	CC
cord-262253-3ovqhypt	335	16	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	335	17	's	's	POS
cord-262253-3ovqhypt	335	18	disease	disease	NN
cord-262253-3ovqhypt	335	19	.	.	.
cord-262253-3ovqhypt	336	1	Front	front	NN
cord-262253-3ovqhypt	336	2	.	.	.
cord-262253-3ovqhypt	337	1	Aging	age	VBG
cord-262253-3ovqhypt	337	2	Neurosci	Neurosci	NNP
cord-262253-3ovqhypt	337	3	Bacterial	bacterial	JJ
cord-262253-3ovqhypt	337	4	infection	infection	NN
cord-262253-3ovqhypt	337	5	and	and	CC
cord-262253-3ovqhypt	337	6	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	337	7	's	's	POS
cord-262253-3ovqhypt	337	8	disease	disease	NN
cord-262253-3ovqhypt	337	9	:	:	:
cord-262253-3ovqhypt	337	10	A	a	DT
cord-262253-3ovqhypt	337	11	meta	meta	JJ
cord-262253-3ovqhypt	337	12	-	-	HYPH
cord-262253-3ovqhypt	337	13	analysis	analysis	NN
cord-262253-3ovqhypt	338	1	The	the	DT
cord-262253-3ovqhypt	338	2	Possibility	possibility	NN
cord-262253-3ovqhypt	338	3	of	of	IN
cord-262253-3ovqhypt	338	4	an	an	DT
cord-262253-3ovqhypt	338	5	Infectious	infectious	JJ
cord-262253-3ovqhypt	338	6	Etiology	etiology	NN
cord-262253-3ovqhypt	338	7	of	of	IN
cord-262253-3ovqhypt	338	8	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	338	9	Disease	Disease	NNP
cord-262253-3ovqhypt	338	10	Encephalopathy	Encephalopathy	NNP
cord-262253-3ovqhypt	338	11	following	follow	VBG
cord-262253-3ovqhypt	338	12	measles	measles	NN
cord-262253-3ovqhypt	338	13	infection	infection	NN
cord-262253-3ovqhypt	338	14	in	in	IN
cord-262253-3ovqhypt	338	15	children	child	NNS
cord-262253-3ovqhypt	338	16	with	with	IN
cord-262253-3ovqhypt	338	17	chronic	chronic	JJ
cord-262253-3ovqhypt	338	18	illness	illness	NN
cord-262253-3ovqhypt	338	19	Herpes	Herpes	NNP
cord-262253-3ovqhypt	338	20	simplex	simplex	NN
cord-262253-3ovqhypt	338	21	virus	virus	NN
cord-262253-3ovqhypt	338	22	type	type	NN
cord-262253-3ovqhypt	338	23	1	1	CD
cord-262253-3ovqhypt	338	24	and	and	CC
cord-262253-3ovqhypt	338	25	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	338	26	's	's	POS
cord-262253-3ovqhypt	338	27	disease	disease	NN
cord-262253-3ovqhypt	338	28	Identification	identification	NN
cord-262253-3ovqhypt	338	29	and	and	CC
cord-262253-3ovqhypt	338	30	localization	localization	NN
cord-262253-3ovqhypt	338	31	of	of	IN
cord-262253-3ovqhypt	338	32	Chlamydia	Chlamydia	NNP
cord-262253-3ovqhypt	338	33	pneumoniae	pneumoniae	NN
cord-262253-3ovqhypt	338	34	in	in	IN
cord-262253-3ovqhypt	338	35	the	the	DT
cord-262253-3ovqhypt	338	36	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	338	37	's	's	POS
cord-262253-3ovqhypt	338	38	brain	brain	NN
cord-262253-3ovqhypt	338	39	Virological	virological	JJ
cord-262253-3ovqhypt	338	40	and	and	CC
cord-262253-3ovqhypt	338	41	immunological	immunological	JJ
cord-262253-3ovqhypt	338	42	characteristics	characteristic	NNS
cord-262253-3ovqhypt	338	43	of	of	IN
cord-262253-3ovqhypt	338	44	human	human	JJ
cord-262253-3ovqhypt	338	45	cytomegalovirus	cytomegalovirus	NN
cord-262253-3ovqhypt	338	46	infection	infection	NN
cord-262253-3ovqhypt	338	47	associated	associate	VBN
cord-262253-3ovqhypt	338	48	with	with	IN
cord-262253-3ovqhypt	338	49	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	338	50	disease	disease	NN
cord-262253-3ovqhypt	338	51	Interaction	Interaction	NNP
cord-262253-3ovqhypt	338	52	between	between	IN
cord-262253-3ovqhypt	338	53	Cytomegalovirus	Cytomegalovirus	NNP
cord-262253-3ovqhypt	338	54	and	and	CC
cord-262253-3ovqhypt	338	55	Herpes	Herpes	NNP
cord-262253-3ovqhypt	338	56	Simplex	Simplex	NNP
cord-262253-3ovqhypt	338	57	Virus	Virus	NNP
cord-262253-3ovqhypt	338	58	Type	type	NN
cord-262253-3ovqhypt	338	59	1	1	CD
cord-262253-3ovqhypt	339	1	Associated	associate	VBN
cord-262253-3ovqhypt	339	2	with	with	IN
cord-262253-3ovqhypt	339	3	the	the	DT
cord-262253-3ovqhypt	339	4	Risk	risk	NN
cord-262253-3ovqhypt	339	5	of	of	IN
cord-262253-3ovqhypt	339	6	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	339	7	's	's	POS
cord-262253-3ovqhypt	339	8	Disease	Disease	NNP
cord-262253-3ovqhypt	339	9	Development	Development	NNP
cord-262253-3ovqhypt	339	10	Interaction	Interaction	NNP
cord-262253-3ovqhypt	339	11	between	between	IN
cord-262253-3ovqhypt	339	12	APOE4	apoe4	NN
cord-262253-3ovqhypt	339	13	and	and	CC
cord-262253-3ovqhypt	339	14	herpes	herpes	NN
cord-262253-3ovqhypt	339	15	simplex	simplex	NNP
cord-262253-3ovqhypt	339	16	virus	virus	NN
cord-262253-3ovqhypt	339	17	type	type	NN
cord-262253-3ovqhypt	339	18	1	1	CD
cord-262253-3ovqhypt	339	19	in	in	IN
cord-262253-3ovqhypt	339	20	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	339	21	's	's	POS
cord-262253-3ovqhypt	339	22	disease	disease	NN
cord-262253-3ovqhypt	339	23	.	.	.
cord-262253-3ovqhypt	340	1	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	340	2	's	's	POS
cord-262253-3ovqhypt	340	3	Dement	Dement	NNP
cord-262253-3ovqhypt	340	4	Recurrent	recurrent	JJ
cord-262253-3ovqhypt	340	5	herpes	herpe	NNS
cord-262253-3ovqhypt	340	6	simplex	simplex	NN
cord-262253-3ovqhypt	340	7	virus-1	virus-1	NNP
cord-262253-3ovqhypt	340	8	infection	infection	NN
cord-262253-3ovqhypt	340	9	induces	induce	VBZ
cord-262253-3ovqhypt	340	10	hallmarks	hallmark	NNS
cord-262253-3ovqhypt	340	11	of	of	IN
cord-262253-3ovqhypt	340	12	neurodegeneration	neurodegeneration	NN
cord-262253-3ovqhypt	340	13	and	and	CC
cord-262253-3ovqhypt	340	14	cognitive	cognitive	JJ
cord-262253-3ovqhypt	340	15	deficits	deficit	NNS
cord-262253-3ovqhypt	340	16	in	in	IN
cord-262253-3ovqhypt	340	17	mice	mouse	NNS
cord-262253-3ovqhypt	340	18	Productive	productive	JJ
cord-262253-3ovqhypt	340	19	herpes	herpe	NNS
cord-262253-3ovqhypt	340	20	simplex	simplex	NN
cord-262253-3ovqhypt	340	21	virus	virus	NN
cord-262253-3ovqhypt	340	22	in	in	IN
cord-262253-3ovqhypt	340	23	brain	brain	NN
cord-262253-3ovqhypt	340	24	of	of	IN
cord-262253-3ovqhypt	340	25	elderly	elderly	JJ
cord-262253-3ovqhypt	340	26	normal	normal	JJ
cord-262253-3ovqhypt	340	27	subjects	subject	NNS
cord-262253-3ovqhypt	340	28	and	and	CC
cord-262253-3ovqhypt	340	29	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	340	30	's	's	POS
cord-262253-3ovqhypt	340	31	disease	disease	NN
cord-262253-3ovqhypt	340	32	patients	patient	NNS
cord-262253-3ovqhypt	340	33	Latent	Latent	NNP
cord-262253-3ovqhypt	340	34	herpes	herpe	NNS
cord-262253-3ovqhypt	340	35	simplex	simplex	NN
cord-262253-3ovqhypt	340	36	virus	virus	NN
cord-262253-3ovqhypt	340	37	type	type	NN
cord-262253-3ovqhypt	340	38	1	1	CD
cord-262253-3ovqhypt	340	39	in	in	IN
cord-262253-3ovqhypt	340	40	normal	normal	JJ
cord-262253-3ovqhypt	340	41	and	and	CC
cord-262253-3ovqhypt	340	42	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	340	43	's	's	POS
cord-262253-3ovqhypt	340	44	disease	disease	NN
cord-262253-3ovqhypt	340	45	brains	brain	NNS
cord-262253-3ovqhypt	340	46	Herpes	Herpes	NNP
cord-262253-3ovqhypt	340	47	virus	virus	NN
cord-262253-3ovqhypt	340	48	in	in	IN
cord-262253-3ovqhypt	340	49	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	340	50	's	's	POS
cord-262253-3ovqhypt	340	51	disease	disease	NN
cord-262253-3ovqhypt	340	52	:	:	:
cord-262253-3ovqhypt	341	1	Relation	relation	NN
cord-262253-3ovqhypt	341	2	to	to	IN
cord-262253-3ovqhypt	341	3	progression	progression	NN
cord-262253-3ovqhypt	341	4	of	of	IN
cord-262253-3ovqhypt	341	5	the	the	DT
cord-262253-3ovqhypt	341	6	disease	disease	NN
cord-262253-3ovqhypt	341	7	Multiscale	Multiscale	NNP
cord-262253-3ovqhypt	341	8	Analysis	Analysis	NNP
cord-262253-3ovqhypt	341	9	of	of	IN
cord-262253-3ovqhypt	341	10	Independent	Independent	NNP
cord-262253-3ovqhypt	341	11	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	341	12	's	's	POS
cord-262253-3ovqhypt	341	13	Cohorts	Cohorts	NNPS
cord-262253-3ovqhypt	341	14	Finds	find	VBZ
cord-262253-3ovqhypt	341	15	Disruption	disruption	NN
cord-262253-3ovqhypt	341	16	of	of	IN
cord-262253-3ovqhypt	341	17	Molecular	Molecular	NNP
cord-262253-3ovqhypt	341	18	,	,	,
cord-262253-3ovqhypt	341	19	Genetic	Genetic	NNP
cord-262253-3ovqhypt	341	20	,	,	,
cord-262253-3ovqhypt	341	21	and	and	CC
cord-262253-3ovqhypt	341	22	Clinical	Clinical	NNP
cord-262253-3ovqhypt	341	23	Networks	Networks	NNP
cord-262253-3ovqhypt	341	24	by	by	IN
cord-262253-3ovqhypt	341	25	Human	Human	NNP
cord-262253-3ovqhypt	341	26	Herpesvirus	Herpesvirus	NNP
cord-262253-3ovqhypt	341	27	Investigation	Investigation	NNP
cord-262253-3ovqhypt	341	28	of	of	IN
cord-262253-3ovqhypt	341	29	Potential	Potential	NNP
cord-262253-3ovqhypt	341	30	Brain	Brain	NNP
cord-262253-3ovqhypt	341	31	Microbiome	Microbiome	NNP
cord-262253-3ovqhypt	341	32	in	in	IN
cord-262253-3ovqhypt	341	33	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	341	34	's	's	POS
cord-262253-3ovqhypt	341	35	Disease	Disease	NNP
cord-262253-3ovqhypt	341	36	:	:	:
cord-262253-3ovqhypt	341	37	Implications	implication	NNS
cord-262253-3ovqhypt	341	38	of	of	IN
cord-262253-3ovqhypt	341	39	Study	Study	NNP
cord-262253-3ovqhypt	341	40	Bias	Bias	NNP
cord-262253-3ovqhypt	341	41	Brain	Brain	NNP
cord-262253-3ovqhypt	341	42	microbiota	microbiota	NN
cord-262253-3ovqhypt	341	43	disruption	disruption	NN
cord-262253-3ovqhypt	341	44	within	within	IN
cord-262253-3ovqhypt	341	45	inflammatory	inflammatory	JJ
cord-262253-3ovqhypt	341	46	demyelinating	demyelinating	JJ
cord-262253-3ovqhypt	341	47	lesions	lesion	NNS
cord-262253-3ovqhypt	341	48	in	in	IN
cord-262253-3ovqhypt	341	49	multiple	multiple	JJ
cord-262253-3ovqhypt	341	50	sclerosis	sclerosis	NN
cord-262253-3ovqhypt	341	51	16S	16S	NNPS
cord-262253-3ovqhypt	341	52	rRNA	rRNA	NNP
cord-262253-3ovqhypt	342	1	Next	next	JJ
cord-262253-3ovqhypt	342	2	Generation	Generation	NNP
cord-262253-3ovqhypt	342	3	Sequencing	Sequencing	NNP
cord-262253-3ovqhypt	342	4	Analysis	Analysis	NNP
cord-262253-3ovqhypt	342	5	Shows	show	VBZ
cord-262253-3ovqhypt	342	6	Bacteria	Bacteria	NNS
cord-262253-3ovqhypt	342	7	in	in	IN
cord-262253-3ovqhypt	342	8	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	342	9	's	's	POS
cord-262253-3ovqhypt	342	10	Post	Post	NNP
cord-262253-3ovqhypt	342	11	-	-	JJ
cord-262253-3ovqhypt	342	12	Mortem	Mortem	NNP
cord-262253-3ovqhypt	342	13	Brain	Brain	NNP
cord-262253-3ovqhypt	342	14	Gram	gram	NN
cord-262253-3ovqhypt	342	15	-	-	HYPH
cord-262253-3ovqhypt	342	16	negative	negative	JJ
cord-262253-3ovqhypt	342	17	bacterial	bacterial	JJ
cord-262253-3ovqhypt	342	18	molecules	molecule	NNS
cord-262253-3ovqhypt	342	19	associate	associate	VBP
cord-262253-3ovqhypt	342	20	with	with	IN
cord-262253-3ovqhypt	342	21	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	342	22	disease	disease	NN
cord-262253-3ovqhypt	342	23	pathology	pathology	NN
cord-262253-3ovqhypt	342	24	Lipopolysaccharide	Lipopolysaccharide	NNP
cord-262253-3ovqhypt	342	25	Associates	Associates	NNPS
cord-262253-3ovqhypt	342	26	with	with	IN
cord-262253-3ovqhypt	342	27	Amyloid	Amyloid	NNP
cord-262253-3ovqhypt	342	28	Plaques	Plaques	NNPS
cord-262253-3ovqhypt	342	29	,	,	,
cord-262253-3ovqhypt	342	30	Neurons	Neurons	NNPS
cord-262253-3ovqhypt	342	31	and	and	CC
cord-262253-3ovqhypt	342	32	Oligodendrocytes	Oligodendrocytes	NNPS
cord-262253-3ovqhypt	342	33	in	in	IN
cord-262253-3ovqhypt	342	34	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	342	35	's	's	POS
cord-262253-3ovqhypt	342	36	Disease	Disease	NNP
cord-262253-3ovqhypt	342	37	Brain	Brain	NNP
cord-262253-3ovqhypt	342	38	:	:	:
cord-262253-3ovqhypt	343	1	A	a	DT
cord-262253-3ovqhypt	343	2	Review	Review	NNP
cord-262253-3ovqhypt	343	3	.	.	.
cord-262253-3ovqhypt	344	1	Front	front	JJ
cord-262253-3ovqhypt	344	2	Borrelia	Borrelia	NNP
cord-262253-3ovqhypt	344	3	burgdorferi	burgdorferi	NN
cord-262253-3ovqhypt	344	4	persists	persist	VBZ
cord-262253-3ovqhypt	344	5	in	in	IN
cord-262253-3ovqhypt	344	6	the	the	DT
cord-262253-3ovqhypt	344	7	brain	brain	NN
cord-262253-3ovqhypt	344	8	in	in	IN
cord-262253-3ovqhypt	344	9	chronic	chronic	JJ
cord-262253-3ovqhypt	344	10	lyme	lyme	NNP
cord-262253-3ovqhypt	344	11	neuroborreliosis	neuroborreliosis	NNP
cord-262253-3ovqhypt	344	12	and	and	CC
cord-262253-3ovqhypt	344	13	may	may	MD
cord-262253-3ovqhypt	344	14	be	be	VB
cord-262253-3ovqhypt	344	15	associated	associate	VBN
cord-262253-3ovqhypt	344	16	with	with	IN
cord-262253-3ovqhypt	344	17	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	344	18	disease	disease	NN
cord-262253-3ovqhypt	344	19	Porphyromonas	Porphyromonas	NNP
cord-262253-3ovqhypt	344	20	gingivalis	gingivali	NNS
cord-262253-3ovqhypt	344	21	in	in	IN
cord-262253-3ovqhypt	344	22	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	344	23	's	's	POS
cord-262253-3ovqhypt	344	24	disease	disease	NN
cord-262253-3ovqhypt	344	25	brains	brain	NNS
cord-262253-3ovqhypt	344	26	:	:	:
cord-262253-3ovqhypt	344	27	Evidence	evidence	NN
cord-262253-3ovqhypt	344	28	for	for	IN
cord-262253-3ovqhypt	344	29	disease	disease	NN
cord-262253-3ovqhypt	344	30	causation	causation	NN
cord-262253-3ovqhypt	344	31	and	and	CC
cord-262253-3ovqhypt	344	32	treatment	treatment	NN
cord-262253-3ovqhypt	344	33	with	with	IN
cord-262253-3ovqhypt	344	34	small	small	JJ
cord-262253-3ovqhypt	344	35	-	-	HYPH
cord-262253-3ovqhypt	344	36	molecule	molecule	NN
cord-262253-3ovqhypt	344	37	inhibitors	inhibitor	NNS
cord-262253-3ovqhypt	344	38	Fungal	fungal	JJ
cord-262253-3ovqhypt	344	39	infection	infection	NN
cord-262253-3ovqhypt	344	40	in	in	IN
cord-262253-3ovqhypt	344	41	patients	patient	NNS
cord-262253-3ovqhypt	344	42	with	with	IN
cord-262253-3ovqhypt	344	43	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	344	44	's	's	POS
cord-262253-3ovqhypt	344	45	disease	disease	NN
cord-262253-3ovqhypt	344	46	.	.	.
cord-262253-3ovqhypt	345	1	J.	J.	NNP
cord-262253-3ovqhypt	345	2	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	345	3	's	's	POS
cord-262253-3ovqhypt	345	4	Dis	Dis	NNP
cord-262253-3ovqhypt	345	5	Different	Different	NNP
cord-262253-3ovqhypt	345	6	Brain	Brain	NNP
cord-262253-3ovqhypt	345	7	Regions	Regions	NNPS
cord-262253-3ovqhypt	345	8	are	be	VBP
cord-262253-3ovqhypt	345	9	Infected	infect	VBN
cord-262253-3ovqhypt	345	10	with	with	IN
cord-262253-3ovqhypt	345	11	Fungi	fungus	NNS
cord-262253-3ovqhypt	345	12	in	in	IN
cord-262253-3ovqhypt	345	13	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	345	14	's	's	POS
cord-262253-3ovqhypt	345	15	Impaired	impair	VBN
cord-262253-3ovqhypt	345	16	Innate	Innate	NNP
cord-262253-3ovqhypt	345	17	Immunity	Immunity	NNP
cord-262253-3ovqhypt	345	18	Mechanisms	Mechanisms	NNPS
cord-262253-3ovqhypt	345	19	in	in	IN
cord-262253-3ovqhypt	345	20	the	the	DT
cord-262253-3ovqhypt	345	21	Brain	Brain	NNP
cord-262253-3ovqhypt	345	22	of	of	IN
cord-262253-3ovqhypt	345	23	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	345	24	's	's	POS
cord-262253-3ovqhypt	345	25	Disease	Disease	NNP
cord-262253-3ovqhypt	346	1	The	the	DT
cord-262253-3ovqhypt	346	2	olfactory	olfactory	JJ
cord-262253-3ovqhypt	346	3	bulb	bulb	NN
cord-262253-3ovqhypt	346	4	as	as	IN
cord-262253-3ovqhypt	346	5	the	the	DT
cord-262253-3ovqhypt	346	6	entry	entry	NN
cord-262253-3ovqhypt	346	7	site	site	NN
cord-262253-3ovqhypt	346	8	for	for	IN
cord-262253-3ovqhypt	346	9	prion	prion	NN
cord-262253-3ovqhypt	346	10	-	-	HYPH
cord-262253-3ovqhypt	346	11	like	like	JJ
cord-262253-3ovqhypt	346	12	propagation	propagation	NN
cord-262253-3ovqhypt	346	13	in	in	IN
cord-262253-3ovqhypt	346	14	neurodegenerative	neurodegenerative	JJ
cord-262253-3ovqhypt	346	15	diseases	disease	NNS
cord-262253-3ovqhypt	347	1	Immunohistological	Immunohistological	NNP
cord-262253-3ovqhypt	347	2	detection	detection	NN
cord-262253-3ovqhypt	347	3	of	of	IN
cord-262253-3ovqhypt	347	4	Chlamydia	Chlamydia	NNP
cord-262253-3ovqhypt	347	5	pneumoniae	pneumoniae	NN
cord-262253-3ovqhypt	347	6	in	in	IN
cord-262253-3ovqhypt	347	7	the	the	DT
cord-262253-3ovqhypt	347	8	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	347	9	's	's	POS
cord-262253-3ovqhypt	347	10	disease	disease	NN
cord-262253-3ovqhypt	347	11	brain	brain	NN
cord-262253-3ovqhypt	348	1	An	an	DT
cord-262253-3ovqhypt	348	2	agent	agent	NN
cord-262253-3ovqhypt	348	3	-	-	HYPH
cord-262253-3ovqhypt	348	4	based	base	VBN
cord-262253-3ovqhypt	348	5	model	model	NN
cord-262253-3ovqhypt	348	6	to	to	TO
cord-262253-3ovqhypt	348	7	investigate	investigate	VB
cord-262253-3ovqhypt	348	8	microbial	microbial	JJ
cord-262253-3ovqhypt	348	9	initiation	initiation	NN
cord-262253-3ovqhypt	348	10	of	of	IN
cord-262253-3ovqhypt	348	11	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	348	12	's	's	POS
cord-262253-3ovqhypt	348	13	via	via	IN
cord-262253-3ovqhypt	348	14	the	the	DT
cord-262253-3ovqhypt	348	15	olfactory	olfactory	JJ
cord-262253-3ovqhypt	348	16	system	system	NN
cord-262253-3ovqhypt	348	17	Chlamydia	Chlamydia	NNP
cord-262253-3ovqhypt	348	18	pneumoniae	pneumoniae	NN
cord-262253-3ovqhypt	348	19	induces	induce	VBZ
cord-262253-3ovqhypt	348	20	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	348	21	-	-	HYPH
cord-262253-3ovqhypt	348	22	like	like	JJ
cord-262253-3ovqhypt	348	23	amyloid	amyloid	NN
cord-262253-3ovqhypt	348	24	plaques	plaque	NNS
cord-262253-3ovqhypt	348	25	in	in	IN
cord-262253-3ovqhypt	348	26	brains	brain	NNS
cord-262253-3ovqhypt	348	27	of	of	IN
cord-262253-3ovqhypt	348	28	BALB	BALB	NNP
cord-262253-3ovqhypt	348	29	/	/	SYM
cord-262253-3ovqhypt	348	30	c	c	NN
cord-262253-3ovqhypt	348	31	mice	mouse	NNS
cord-262253-3ovqhypt	349	1	Chlamydia	Chlamydia	NNP
cord-262253-3ovqhypt	349	2	Pneumoniae	Pneumoniae	NNP
cord-262253-3ovqhypt	349	3	Infection	infection	NN
cord-262253-3ovqhypt	349	4	of	of	IN
cord-262253-3ovqhypt	349	5	Neuronal	Neuronal	NNP
cord-262253-3ovqhypt	349	6	Cells	Cells	NNPS
cord-262253-3ovqhypt	349	7	Induces	induce	VBZ
cord-262253-3ovqhypt	349	8	Changes	change	NNS
cord-262253-3ovqhypt	349	9	in	in	IN
cord-262253-3ovqhypt	349	10	Calcium	Calcium	NNP
cord-262253-3ovqhypt	349	11	-	-	HYPH
cord-262253-3ovqhypt	349	12	Associated	Associated	NNP
cord-262253-3ovqhypt	349	13	Gene	Gene	NNP
cord-262253-3ovqhypt	349	14	Expression	Expression	NNP
cord-262253-3ovqhypt	349	15	Consistent	Consistent	NNP
cord-262253-3ovqhypt	349	16	with	with	IN
cord-262253-3ovqhypt	349	17	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	349	18	's	's	POS
cord-262253-3ovqhypt	349	19	Disease	Disease	NNP
cord-262253-3ovqhypt	349	20	Prion	Prion	NNP
cord-262253-3ovqhypt	349	21	-	-	HYPH
cord-262253-3ovqhypt	349	22	like	like	JJ
cord-262253-3ovqhypt	349	23	Domains	domain	NNS
cord-262253-3ovqhypt	349	24	in	in	IN
cord-262253-3ovqhypt	349	25	Eukaryotic	eukaryotic	JJ
cord-262253-3ovqhypt	349	26	Viruses	virus	NNS
cord-262253-3ovqhypt	350	1	Herpes	Herpes	NNP
cord-262253-3ovqhypt	350	2	simplex	simplex	NN
cord-262253-3ovqhypt	350	3	virus	virus	NN
cord-262253-3ovqhypt	350	4	infection	infection	NN
cord-262253-3ovqhypt	350	5	causes	cause	VBZ
cord-262253-3ovqhypt	350	6	cellular	cellular	JJ
cord-262253-3ovqhypt	350	7	beta	beta	JJ
cord-262253-3ovqhypt	350	8	-	-	HYPH
cord-262253-3ovqhypt	350	9	amyloid	amyloid	NN
cord-262253-3ovqhypt	350	10	accumulation	accumulation	NN
cord-262253-3ovqhypt	350	11	and	and	CC
cord-262253-3ovqhypt	350	12	secretase	secretase	NN
cord-262253-3ovqhypt	350	13	upregulation	upregulation	NN
cord-262253-3ovqhypt	350	14	Establishment	Establishment	NNP
cord-262253-3ovqhypt	350	15	of	of	IN
cord-262253-3ovqhypt	350	16	an	an	DT
cord-262253-3ovqhypt	350	17	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	350	18	's	's	POS
cord-262253-3ovqhypt	350	19	disease	disease	NN
cord-262253-3ovqhypt	350	20	model	model	NN
cord-262253-3ovqhypt	350	21	with	with	IN
cord-262253-3ovqhypt	350	22	latent	latent	JJ
cord-262253-3ovqhypt	350	23	herpesvirus	herpesvirus	NN
cord-262253-3ovqhypt	350	24	infection	infection	NN
cord-262253-3ovqhypt	350	25	using	use	VBG
cord-262253-3ovqhypt	350	26	PS2	PS2	NNP
cord-262253-3ovqhypt	350	27	and	and	CC
cord-262253-3ovqhypt	350	28	Tg2576	Tg2576	NNP
cord-262253-3ovqhypt	350	29	double	double	JJ
cord-262253-3ovqhypt	350	30	transgenic	transgenic	JJ
cord-262253-3ovqhypt	350	31	mice	mouse	NNS
cord-262253-3ovqhypt	351	1	Periodontitis	periodontitis	NN
cord-262253-3ovqhypt	351	2	induced	induce	VBN
cord-262253-3ovqhypt	351	3	by	by	IN
cord-262253-3ovqhypt	351	4	bacterial	bacterial	JJ
cord-262253-3ovqhypt	351	5	infection	infection	NN
cord-262253-3ovqhypt	351	6	exacerbates	exacerbate	VBZ
cord-262253-3ovqhypt	351	7	features	feature	NNS
cord-262253-3ovqhypt	351	8	of	of	IN
cord-262253-3ovqhypt	351	9	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	351	10	's	's	POS
cord-262253-3ovqhypt	351	11	disease	disease	NN
cord-262253-3ovqhypt	351	12	in	in	IN
cord-262253-3ovqhypt	351	13	transgenic	transgenic	JJ
cord-262253-3ovqhypt	351	14	mice	mouse	NNS
cord-262253-3ovqhypt	352	1	The	the	DT
cord-262253-3ovqhypt	352	2	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	352	3	protection	protection	NN
cord-262253-3ovqhypt	352	4	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	352	5	of	of	IN
cord-262253-3ovqhypt	352	6	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	352	7	's	's	POS
cord-262253-3ovqhypt	352	8	disease	disease	NN
cord-262253-3ovqhypt	352	9	Protective	Protective	NNP
cord-262253-3ovqhypt	352	10	Effect	Effect	NNP
cord-262253-3ovqhypt	352	11	of	of	IN
cord-262253-3ovqhypt	352	12	Amyloid	amyloid	NN
cord-262253-3ovqhypt	352	13	-	-	HYPH
cord-262253-3ovqhypt	352	14	beta	beta	NN
cord-262253-3ovqhypt	352	15	Peptides	peptide	NNS
cord-262253-3ovqhypt	352	16	Against	against	IN
cord-262253-3ovqhypt	352	17	Herpes	Herpes	NNP
cord-262253-3ovqhypt	352	18	Simplex	Simplex	NNP
cord-262253-3ovqhypt	352	19	Virus-1	Virus-1	NNP
cord-262253-3ovqhypt	352	20	Infection	infection	NN
cord-262253-3ovqhypt	352	21	in	in	IN
cord-262253-3ovqhypt	352	22	a	a	DT
cord-262253-3ovqhypt	352	23	Neuronal	Neuronal	NNP
cord-262253-3ovqhypt	352	24	Cell	Cell	NNP
cord-262253-3ovqhypt	352	25	Culture	Culture	NNP
cord-262253-3ovqhypt	352	26	Model	Model	NNP
cord-262253-3ovqhypt	352	27	APP	app	NN
cord-262253-3ovqhypt	352	28	processing	processing	NN
cord-262253-3ovqhypt	352	29	induced	induce	VBN
cord-262253-3ovqhypt	352	30	by	by	IN
cord-262253-3ovqhypt	352	31	herpes	herpes	NNP
cord-262253-3ovqhypt	352	32	simplex	simplex	NNP
cord-262253-3ovqhypt	352	33	virus	virus	NN
cord-262253-3ovqhypt	352	34	type	type	NN
cord-262253-3ovqhypt	352	35	1	1	CD
cord-262253-3ovqhypt	352	36	(	(	-LRB-
cord-262253-3ovqhypt	352	37	HSV-1	hsv-1	NN
cord-262253-3ovqhypt	352	38	)	)	-RRB-
cord-262253-3ovqhypt	352	39	yields	yield	VBZ
cord-262253-3ovqhypt	352	40	several	several	JJ
cord-262253-3ovqhypt	352	41	APP	app	NN
cord-262253-3ovqhypt	352	42	fragments	fragment	NNS
cord-262253-3ovqhypt	352	43	in	in	IN
cord-262253-3ovqhypt	352	44	human	human	NN
cord-262253-3ovqhypt	352	45	and	and	CC
cord-262253-3ovqhypt	352	46	rat	rat	NN
cord-262253-3ovqhypt	352	47	neuronal	neuronal	JJ
cord-262253-3ovqhypt	352	48	cells	cell	NNS
cord-262253-3ovqhypt	352	49	Herpes	Herpes	NNP
cord-262253-3ovqhypt	352	50	simplex	simplex	NN
cord-262253-3ovqhypt	352	51	virus	virus	NN
cord-262253-3ovqhypt	352	52	type	type	NN
cord-262253-3ovqhypt	352	53	I	-PRON-	PRP
cord-262253-3ovqhypt	352	54	induces	induce	VBZ
cord-262253-3ovqhypt	352	55	the	the	DT
cord-262253-3ovqhypt	352	56	accumulation	accumulation	NN
cord-262253-3ovqhypt	352	57	of	of	IN
cord-262253-3ovqhypt	352	58	intracellular	intracellular	JJ
cord-262253-3ovqhypt	352	59	beta	beta	NN
cord-262253-3ovqhypt	352	60	-	-	HYPH
cord-262253-3ovqhypt	352	61	amyloid	amyloid	NN
cord-262253-3ovqhypt	352	62	in	in	IN
cord-262253-3ovqhypt	352	63	autophagic	autophagic	NNP
cord-262253-3ovqhypt	352	64	compartments	compartment	NNS
cord-262253-3ovqhypt	352	65	and	and	CC
cord-262253-3ovqhypt	352	66	the	the	DT
cord-262253-3ovqhypt	352	67	inhibition	inhibition	NN
cord-262253-3ovqhypt	352	68	of	of	IN
cord-262253-3ovqhypt	352	69	the	the	DT
cord-262253-3ovqhypt	352	70	non	non	JJ
cord-262253-3ovqhypt	352	71	-	-	JJ
cord-262253-3ovqhypt	352	72	amyloidogenic	amyloidogenic	JJ
cord-262253-3ovqhypt	352	73	pathway	pathway	NN
cord-262253-3ovqhypt	352	74	in	in	IN
cord-262253-3ovqhypt	352	75	human	human	JJ
cord-262253-3ovqhypt	352	76	neuroblastoma	neuroblastoma	NN
cord-262253-3ovqhypt	352	77	cells	cell	NNS
cord-262253-3ovqhypt	353	1	Herpes	Herpes	NNP
cord-262253-3ovqhypt	353	2	Simplex	Simplex	NNP
cord-262253-3ovqhypt	353	3	Virus	Virus	NNP
cord-262253-3ovqhypt	353	4	Type-1	type-1	NN
cord-262253-3ovqhypt	353	5	Infection	infection	NN
cord-262253-3ovqhypt	353	6	Impairs	impair	VBZ
cord-262253-3ovqhypt	353	7	Adult	Adult	NNP
cord-262253-3ovqhypt	353	8	Hippocampal	Hippocampal	NNP
cord-262253-3ovqhypt	353	9	Neurogenesis	Neurogenesis	NNP
cord-262253-3ovqhypt	353	10	via	via	IN
cord-262253-3ovqhypt	353	11	Amyloid	amyloid	NN
cord-262253-3ovqhypt	353	12	-	-	HYPH
cord-262253-3ovqhypt	353	13	beta	beta	NN
cord-262253-3ovqhypt	353	14	Protein	Protein	NNP
cord-262253-3ovqhypt	353	15	Accumulation	Accumulation	NNP
cord-262253-3ovqhypt	353	16	Herpes	Herpes	NNP
cord-262253-3ovqhypt	353	17	Simplex	Simplex	NNP
cord-262253-3ovqhypt	353	18	Virus	Virus	NNP
cord-262253-3ovqhypt	353	19	type-1	type-1	NN
cord-262253-3ovqhypt	353	20	infection	infection	NN
cord-262253-3ovqhypt	353	21	induces	induce	VBZ
cord-262253-3ovqhypt	353	22	synaptic	synaptic	JJ
cord-262253-3ovqhypt	353	23	dysfunction	dysfunction	NN
cord-262253-3ovqhypt	353	24	in	in	IN
cord-262253-3ovqhypt	353	25	cultured	cultured	JJ
cord-262253-3ovqhypt	353	26	cortical	cortical	JJ
cord-262253-3ovqhypt	353	27	neurons	neuron	NNS
cord-262253-3ovqhypt	353	28	via	via	IN
cord-262253-3ovqhypt	353	29	GSK-3	GSK-3	NNP
cord-262253-3ovqhypt	353	30	activation	activation	NN
cord-262253-3ovqhypt	353	31	and	and	CC
cord-262253-3ovqhypt	353	32	intraneuronal	intraneuronal	JJ
cord-262253-3ovqhypt	353	33	amyloid	amyloid	NN
cord-262253-3ovqhypt	353	34	-	-	HYPH
cord-262253-3ovqhypt	353	35	beta	beta	NN
cord-262253-3ovqhypt	353	36	protein	protein	NN
cord-262253-3ovqhypt	353	37	accumulation	accumulation	NN
cord-262253-3ovqhypt	353	38	Herpes	Herpes	NNP
cord-262253-3ovqhypt	353	39	simplex	simplex	NN
cord-262253-3ovqhypt	353	40	virus	virus	NN
cord-262253-3ovqhypt	353	41	type	type	NN
cord-262253-3ovqhypt	353	42	2	2	CD
cord-262253-3ovqhypt	353	43	infection	infection	NN
cord-262253-3ovqhypt	353	44	induces	induce	VBZ
cord-262253-3ovqhypt	353	45	AD	ad	NN
cord-262253-3ovqhypt	353	46	-	-	HYPH
cord-262253-3ovqhypt	353	47	like	like	JJ
cord-262253-3ovqhypt	353	48	neurodegeneration	neurodegeneration	NN
cord-262253-3ovqhypt	353	49	markers	marker	NNS
cord-262253-3ovqhypt	353	50	in	in	IN
cord-262253-3ovqhypt	353	51	human	human	JJ
cord-262253-3ovqhypt	353	52	neuroblastoma	neuroblastoma	NN
cord-262253-3ovqhypt	353	53	cells	cell	NNS
cord-262253-3ovqhypt	353	54	Beta	beta	JJ
cord-262253-3ovqhypt	353	55	-	-	HYPH
cord-262253-3ovqhypt	353	56	amyloid	amyloid	NN
cord-262253-3ovqhypt	353	57	deposition	deposition	NN
cord-262253-3ovqhypt	353	58	and	and	CC
cord-262253-3ovqhypt	353	59	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	353	60	's	's	POS
cord-262253-3ovqhypt	353	61	type	type	NN
cord-262253-3ovqhypt	353	62	changes	change	NNS
cord-262253-3ovqhypt	353	63	induced	induce	VBN
cord-262253-3ovqhypt	353	64	by	by	IN
cord-262253-3ovqhypt	353	65	Borrelia	Borrelia	NNP
cord-262253-3ovqhypt	353	66	spirochetes	spirochete	NNS
cord-262253-3ovqhypt	354	1	Porphyromonas	Porphyromonas	NNP
cord-262253-3ovqhypt	354	2	gingivalis	gingivali	VBZ
cord-262253-3ovqhypt	354	3	Infection	infection	NN
cord-262253-3ovqhypt	354	4	Induces	induce	VBZ
cord-262253-3ovqhypt	354	5	Amyloid	Amyloid	NNP
cord-262253-3ovqhypt	354	6	-	-	HYPH
cord-262253-3ovqhypt	354	7	beta	beta	NN
cord-262253-3ovqhypt	354	8	Accumulation	Accumulation	NNP
cord-262253-3ovqhypt	354	9	in	in	IN
cord-262253-3ovqhypt	354	10	Monocytes	Monocytes	NNPS
cord-262253-3ovqhypt	354	11	/	/	SYM
cord-262253-3ovqhypt	354	12	Macrophages	macrophage	NNS
cord-262253-3ovqhypt	354	13	.	.	.
cord-262253-3ovqhypt	355	1	J.	J.	NNP
cord-262253-3ovqhypt	355	2	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	355	3	's	's	POS
cord-262253-3ovqhypt	355	4	Dis	Dis	NNP
cord-262253-3ovqhypt	355	5	Herpes	Herpes	NNP
cord-262253-3ovqhypt	355	6	simplex	simplex	NN
cord-262253-3ovqhypt	355	7	virus	virus	NN
cord-262253-3ovqhypt	355	8	dances	dance	VBZ
cord-262253-3ovqhypt	355	9	with	with	IN
cord-262253-3ovqhypt	355	10	amyloid	amyloid	NN
cord-262253-3ovqhypt	355	11	precursor	precursor	NN
cord-262253-3ovqhypt	355	12	protein	protein	NN
cord-262253-3ovqhypt	355	13	while	while	IN
cord-262253-3ovqhypt	355	14	exiting	exit	VBG
cord-262253-3ovqhypt	355	15	the	the	DT
cord-262253-3ovqhypt	355	16	cell	cell	NN
cord-262253-3ovqhypt	355	17	Brain	Brain	NNP
cord-262253-3ovqhypt	355	18	deposition	deposition	NN
cord-262253-3ovqhypt	355	19	of	of	IN
cord-262253-3ovqhypt	355	20	beta	beta	JJ
cord-262253-3ovqhypt	355	21	-	-	HYPH
cord-262253-3ovqhypt	355	22	amyloid	amyloid	JJ
cord-262253-3ovqhypt	356	1	is	be	VBZ
cord-262253-3ovqhypt	356	2	a	a	DT
cord-262253-3ovqhypt	356	3	common	common	JJ
cord-262253-3ovqhypt	356	4	pathologic	pathologic	JJ
cord-262253-3ovqhypt	356	5	feature	feature	NN
cord-262253-3ovqhypt	356	6	in	in	IN
cord-262253-3ovqhypt	356	7	HIV	HIV	NNP
cord-262253-3ovqhypt	356	8	positive	positive	JJ
cord-262253-3ovqhypt	356	9	patients	patient	NNS
cord-262253-3ovqhypt	356	10	Nef	Nef	NNP
cord-262253-3ovqhypt	356	11	exosomes	exosome	NNS
cord-262253-3ovqhypt	356	12	isolated	isolate	VBN
cord-262253-3ovqhypt	356	13	from	from	IN
cord-262253-3ovqhypt	356	14	the	the	DT
cord-262253-3ovqhypt	356	15	plasma	plasma	NN
cord-262253-3ovqhypt	356	16	of	of	IN
cord-262253-3ovqhypt	356	17	individuals	individual	NNS
cord-262253-3ovqhypt	356	18	with	with	IN
cord-262253-3ovqhypt	356	19	HIV	HIV	NNP
cord-262253-3ovqhypt	356	20	-	-	HYPH
cord-262253-3ovqhypt	356	21	associated	associate	VBN
cord-262253-3ovqhypt	356	22	dementia	dementia	NN
cord-262253-3ovqhypt	356	23	(	(	-LRB-
cord-262253-3ovqhypt	356	24	HAD	have	VBD
cord-262253-3ovqhypt	356	25	)	)	-RRB-
cord-262253-3ovqhypt	356	26	can	can	MD
cord-262253-3ovqhypt	356	27	induce	induce	VB
cord-262253-3ovqhypt	356	28	Aβ(1	Aβ(1	NNP
cord-262253-3ovqhypt	356	29	-	-	SYM
cord-262253-3ovqhypt	356	30	42	42	CD
cord-262253-3ovqhypt	356	31	)	)	-RRB-
cord-262253-3ovqhypt	356	32	secretion	secretion	NN
cord-262253-3ovqhypt	356	33	in	in	IN
cord-262253-3ovqhypt	356	34	SH	sh	NN
cord-262253-3ovqhypt	356	35	-	-	HYPH
cord-262253-3ovqhypt	356	36	SY5Y	sy5y	JJ
cord-262253-3ovqhypt	356	37	neural	neural	JJ
cord-262253-3ovqhypt	356	38	cells	cell	NNS
cord-262253-3ovqhypt	357	1	A	a	DT
cord-262253-3ovqhypt	357	2	genetic	genetic	JJ
cord-262253-3ovqhypt	357	3	signature	signature	NN
cord-262253-3ovqhypt	357	4	including	include	VBG
cord-262253-3ovqhypt	357	5	apolipoprotein	apolipoprotein	NN
cord-262253-3ovqhypt	357	6	Eε4	eε4	NN
cord-262253-3ovqhypt	357	7	potentiates	potentiate	VBZ
cord-262253-3ovqhypt	357	8	the	the	DT
cord-262253-3ovqhypt	357	9	risk	risk	NN
cord-262253-3ovqhypt	357	10	of	of	IN
cord-262253-3ovqhypt	357	11	herpes	herpes	NN
cord-262253-3ovqhypt	357	12	simplex	simplex	NN
cord-262253-3ovqhypt	357	13	-	-	HYPH
cord-262253-3ovqhypt	357	14	associated	associate	VBN
cord-262253-3ovqhypt	357	15	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	357	16	's	's	POS
cord-262253-3ovqhypt	357	17	disease	disease	NN
cord-262253-3ovqhypt	357	18	Herpes	Herpes	NNP
cord-262253-3ovqhypt	357	19	simplex	simplex	NN
cord-262253-3ovqhypt	357	20	virus	virus	NN
cord-262253-3ovqhypt	357	21	type	type	NN
cord-262253-3ovqhypt	357	22	1	1	CD
cord-262253-3ovqhypt	357	23	in	in	IN
cord-262253-3ovqhypt	357	24	brain	brain	NN
cord-262253-3ovqhypt	357	25	and	and	CC
cord-262253-3ovqhypt	357	26	risk	risk	NN
cord-262253-3ovqhypt	357	27	of	of	IN
cord-262253-3ovqhypt	357	28	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	357	29	's	's	POS
cord-262253-3ovqhypt	357	30	disease	disease	NN
cord-262253-3ovqhypt	358	1	ApoE4	ApoE4	NNP
cord-262253-3ovqhypt	358	2	is	be	VBZ
cord-262253-3ovqhypt	358	3	more	more	RBR
cord-262253-3ovqhypt	358	4	efficient	efficient	JJ
cord-262253-3ovqhypt	358	5	than	than	IN
cord-262253-3ovqhypt	358	6	E3	E3	NNP
cord-262253-3ovqhypt	358	7	in	in	IN
cord-262253-3ovqhypt	358	8	brain	brain	NN
cord-262253-3ovqhypt	358	9	access	access	NN
cord-262253-3ovqhypt	358	10	by	by	IN
cord-262253-3ovqhypt	358	11	herpes	herpes	NNP
cord-262253-3ovqhypt	358	12	simplex	simplex	NNP
cord-262253-3ovqhypt	358	13	virus	virus	NN
cord-262253-3ovqhypt	358	14	type	type	NN
cord-262253-3ovqhypt	358	15	1	1	CD
cord-262253-3ovqhypt	358	16	Herpes	Herpes	NNP
cord-262253-3ovqhypt	358	17	simplex	simplex	NN
cord-262253-3ovqhypt	358	18	virus	virus	NN
cord-262253-3ovqhypt	358	19	type	type	NN
cord-262253-3ovqhypt	358	20	1	1	CD
cord-262253-3ovqhypt	358	21	DNA	DNA	NNP
cord-262253-3ovqhypt	358	22	is	be	VBZ
cord-262253-3ovqhypt	358	23	located	locate	VBN
cord-262253-3ovqhypt	358	24	within	within	IN
cord-262253-3ovqhypt	358	25	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	358	26	's	's	POS
cord-262253-3ovqhypt	358	27	disease	disease	NN
cord-262253-3ovqhypt	358	28	amyloid	amyloid	NN
cord-262253-3ovqhypt	358	29	plaques	plaque	NNS
cord-262253-3ovqhypt	358	30	Beta	beta	JJ
cord-262253-3ovqhypt	358	31	-	-	HYPH
cord-262253-3ovqhypt	358	32	amyloid	amyloid	NN
cord-262253-3ovqhypt	358	33	peptide	peptide	NN
cord-262253-3ovqhypt	358	34	secretion	secretion	NN
cord-262253-3ovqhypt	358	35	by	by	IN
cord-262253-3ovqhypt	358	36	a	a	DT
cord-262253-3ovqhypt	358	37	microglial	microglial	JJ
cord-262253-3ovqhypt	358	38	cell	cell	NN
cord-262253-3ovqhypt	358	39	line	line	NN
cord-262253-3ovqhypt	358	40	is	be	VBZ
cord-262253-3ovqhypt	358	41	induced	induce	VBN
cord-262253-3ovqhypt	358	42	by	by	IN
cord-262253-3ovqhypt	358	43	beta	beta	NN
cord-262253-3ovqhypt	358	44	-	-	HYPH
cord-262253-3ovqhypt	358	45	amyloid-(25	amyloid-(25	CD
cord-262253-3ovqhypt	358	46	-	-	HYPH
cord-262253-3ovqhypt	358	47	35	35	CD
cord-262253-3ovqhypt	358	48	)	)	-RRB-
cord-262253-3ovqhypt	358	49	and	and	CC
cord-262253-3ovqhypt	358	50	lipopolysaccharide	lipopolysaccharide	NN
cord-262253-3ovqhypt	359	1	The	the	DT
cord-262253-3ovqhypt	359	2	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	359	3	's	's	POS
cord-262253-3ovqhypt	359	4	disease	disease	NN
cord-262253-3ovqhypt	359	5	-	-	HYPH
cord-262253-3ovqhypt	359	6	associated	associate	VBN
cord-262253-3ovqhypt	359	7	amyloid	amyloid	NN
cord-262253-3ovqhypt	359	8	beta	beta	NN
cord-262253-3ovqhypt	359	9	-	-	HYPH
cord-262253-3ovqhypt	359	10	protein	protein	NN
cord-262253-3ovqhypt	359	11	is	be	VBZ
cord-262253-3ovqhypt	360	1	an	an	DT
cord-262253-3ovqhypt	360	2	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	360	3	peptide	peptide	NN
cord-262253-3ovqhypt	360	4	Toxicity	toxicity	NN
cord-262253-3ovqhypt	360	5	of	of	IN
cord-262253-3ovqhypt	360	6	eosinophil	eosinophil	NN
cord-262253-3ovqhypt	360	7	MBP	MBP	NNP
cord-262253-3ovqhypt	360	8	is	be	VBZ
cord-262253-3ovqhypt	360	9	repressed	repress	VBN
cord-262253-3ovqhypt	360	10	by	by	IN
cord-262253-3ovqhypt	360	11	intracellular	intracellular	JJ
cord-262253-3ovqhypt	360	12	crystallization	crystallization	NN
cord-262253-3ovqhypt	360	13	and	and	CC
cord-262253-3ovqhypt	360	14	promoted	promote	VBN
cord-262253-3ovqhypt	360	15	by	by	IN
cord-262253-3ovqhypt	360	16	extracellular	extracellular	JJ
cord-262253-3ovqhypt	360	17	aggregation	aggregation	NN
cord-262253-3ovqhypt	361	1	Why	why	WRB
cord-262253-3ovqhypt	361	2	does	do	VBZ
cord-262253-3ovqhypt	361	3	the	the	DT
cord-262253-3ovqhypt	361	4	Aβ	Aβ	NNP
cord-262253-3ovqhypt	361	5	peptide	peptide	NN
cord-262253-3ovqhypt	361	6	of	of	IN
cord-262253-3ovqhypt	361	7	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	361	8	share	share	VBP
cord-262253-3ovqhypt	361	9	structural	structural	JJ
cord-262253-3ovqhypt	361	10	similarity	similarity	NN
cord-262253-3ovqhypt	361	11	with	with	IN
cord-262253-3ovqhypt	361	12	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	361	13	peptides	peptide	NNS
cord-262253-3ovqhypt	361	14	?	?	.
cord-262253-3ovqhypt	362	1	The	the	DT
cord-262253-3ovqhypt	362	2	Fate	Fate	NNP
cord-262253-3ovqhypt	362	3	of	of	IN
cord-262253-3ovqhypt	362	4	Bacteriocins	Bacteriocins	NNP
cord-262253-3ovqhypt	362	5	in	in	IN
cord-262253-3ovqhypt	362	6	the	the	DT
cord-262253-3ovqhypt	362	7	Human	Human	NNP
cord-262253-3ovqhypt	362	8	Gastro	Gastro	NNP
cord-262253-3ovqhypt	362	9	-	-	HYPH
cord-262253-3ovqhypt	362	10	Intestinal	intestinal	JJ
cord-262253-3ovqhypt	362	11	Tract	tract	NN
cord-262253-3ovqhypt	363	1	:	:	:
cord-262253-3ovqhypt	363	2	Do	do	VBP
cord-262253-3ovqhypt	363	3	They	-PRON-	PRP
cord-262253-3ovqhypt	363	4	Cross	cross	VB
cord-262253-3ovqhypt	363	5	the	the	DT
cord-262253-3ovqhypt	363	6	Gut	gut	NN
cord-262253-3ovqhypt	363	7	-	-	HYPH
cord-262253-3ovqhypt	363	8	Blood	Blood	NNP
cord-262253-3ovqhypt	363	9	Barrier	Barrier	NNP
cord-262253-3ovqhypt	363	10	?	?	.
cord-262253-3ovqhypt	364	1	Antimicrobial	Antimicrobial	NNP
cord-262253-3ovqhypt	364	2	peptide	peptide	NN
cord-262253-3ovqhypt	364	3	β	β	NN
cord-262253-3ovqhypt	364	4	-	-	HYPH
cord-262253-3ovqhypt	364	5	defensin-1	defensin-1	NNP
cord-262253-3ovqhypt	364	6	expression	expression	NN
cord-262253-3ovqhypt	364	7	is	be	VBZ
cord-262253-3ovqhypt	364	8	upregulated	upregulate	VBN
cord-262253-3ovqhypt	364	9	in	in	IN
cord-262253-3ovqhypt	364	10	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	364	11	's	's	POS
cord-262253-3ovqhypt	364	12	brain	brain	NN
cord-262253-3ovqhypt	365	1	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	365	2	's	's	POS
cord-262253-3ovqhypt	365	3	associated	associated	JJ
cord-262253-3ovqhypt	365	4	β	β	NN
cord-262253-3ovqhypt	365	5	-	-	HYPH
cord-262253-3ovqhypt	365	6	amyloid	amyloid	NN
cord-262253-3ovqhypt	365	7	protein	protein	NN
cord-262253-3ovqhypt	365	8	inhibits	inhibit	VBZ
cord-262253-3ovqhypt	365	9	influenza	influenza	NN
cord-262253-3ovqhypt	365	10	A	a	DT
cord-262253-3ovqhypt	365	11	virus	virus	NN
cord-262253-3ovqhypt	365	12	and	and	CC
cord-262253-3ovqhypt	365	13	modulates	modulate	VBZ
cord-262253-3ovqhypt	365	14	viral	viral	JJ
cord-262253-3ovqhypt	365	15	interactions	interaction	NNS
cord-262253-3ovqhypt	365	16	with	with	IN
cord-262253-3ovqhypt	366	1	phagocytes	phagocyte	NNS
cord-262253-3ovqhypt	366	2	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	366	3	's	's	POS
cord-262253-3ovqhypt	366	4	Disease	Disease	NNP
cord-262253-3ovqhypt	366	5	-	-	HYPH
cord-262253-3ovqhypt	366	6	Associated	Associated	NNP
cord-262253-3ovqhypt	366	7	β	β	NNP
cord-262253-3ovqhypt	366	8	-	-	HYPH
cord-262253-3ovqhypt	366	9	Amyloid	Amyloid	NNP
cord-262253-3ovqhypt	366	10	Is	be	VBZ
cord-262253-3ovqhypt	366	11	Rapidly	rapidly	RB
cord-262253-3ovqhypt	366	12	Seeded	seed	VBN
cord-262253-3ovqhypt	366	13	by	by	IN
cord-262253-3ovqhypt	366	14	Herpesviridae	Herpesviridae	NNP
cord-262253-3ovqhypt	366	15	to	to	TO
cord-262253-3ovqhypt	366	16	Protect	protect	VB
cord-262253-3ovqhypt	366	17	against	against	IN
cord-262253-3ovqhypt	366	18	Brain	Brain	NNP
cord-262253-3ovqhypt	366	19	Infection	Infection	NNP
cord-262253-3ovqhypt	366	20	Amyloidogenic	Amyloidogenic	NNP
cord-262253-3ovqhypt	366	21	amyloid	amyloid	NN
cord-262253-3ovqhypt	366	22	-	-	HYPH
cord-262253-3ovqhypt	366	23	β	β	NN
cord-262253-3ovqhypt	366	24	-	-	HYPH
cord-262253-3ovqhypt	366	25	peptide	peptide	NN
cord-262253-3ovqhypt	366	26	variants	variant	NNS
cord-262253-3ovqhypt	367	1	induce	induce	VB
cord-262253-3ovqhypt	367	2	microbial	microbial	JJ
cord-262253-3ovqhypt	367	3	agglutination	agglutination	NN
cord-262253-3ovqhypt	367	4	and	and	CC
cord-262253-3ovqhypt	367	5	exert	exert	VB
cord-262253-3ovqhypt	367	6	antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	367	7	activity	activity	NN
cord-262253-3ovqhypt	367	8	Amyloid	Amyloid	NNP
cord-262253-3ovqhypt	367	9	-	-	HYPH
cord-262253-3ovqhypt	367	10	β	β	NN
cord-262253-3ovqhypt	367	11	peptide	peptide	NN
cord-262253-3ovqhypt	367	12	protects	protect	VBZ
cord-262253-3ovqhypt	367	13	against	against	IN
cord-262253-3ovqhypt	367	14	microbial	microbial	JJ
cord-262253-3ovqhypt	367	15	infection	infection	NN
cord-262253-3ovqhypt	367	16	in	in	IN
cord-262253-3ovqhypt	367	17	mouse	mouse	NN
cord-262253-3ovqhypt	367	18	and	and	CC
cord-262253-3ovqhypt	367	19	worm	worm	NN
cord-262253-3ovqhypt	367	20	models	model	NNS
cord-262253-3ovqhypt	367	21	of	of	IN
cord-262253-3ovqhypt	367	22	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	367	23	's	's	POS
cord-262253-3ovqhypt	367	24	disease	disease	NN
cord-262253-3ovqhypt	367	25	Phenotypic	Phenotypic	NNP
cord-262253-3ovqhypt	367	26	and	and	CC
cord-262253-3ovqhypt	367	27	Biochemical	Biochemical	NNP
cord-262253-3ovqhypt	367	28	Analyses	Analyses	NNPS
cord-262253-3ovqhypt	367	29	of	of	IN
cord-262253-3ovqhypt	367	30	BACE1-and	BACE1-and	NNP
cord-262253-3ovqhypt	368	1	BACE2-deficient	BACE2-deficient	NNP
cord-262253-3ovqhypt	368	2	Mice	mouse	NNS
cord-262253-3ovqhypt	369	1	The	the	DT
cord-262253-3ovqhypt	369	2	amyloid	amyloid	NN
cord-262253-3ovqhypt	369	3	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	369	4	:	:	:
cord-262253-3ovqhypt	369	5	Let	let	VB
cord-262253-3ovqhypt	369	6	sleeping	sleep	VBG
cord-262253-3ovqhypt	369	7	dogmas	dogma	NNS
cord-262253-3ovqhypt	369	8	lie	lie	VB
cord-262253-3ovqhypt	369	9	?	?	.
cord-262253-3ovqhypt	370	1	Abeta	Abeta	NNP
cord-262253-3ovqhypt	370	2	as	as	IN
cord-262253-3ovqhypt	370	3	a	a	DT
cord-262253-3ovqhypt	370	4	bioflocculant	bioflocculant	NN
cord-262253-3ovqhypt	370	5	:	:	:
cord-262253-3ovqhypt	370	6	Implications	implication	NNS
cord-262253-3ovqhypt	370	7	for	for	IN
cord-262253-3ovqhypt	370	8	the	the	DT
cord-262253-3ovqhypt	370	9	amyloid	amyloid	NN
cord-262253-3ovqhypt	370	10	hypothesis	hypothesis	NN
cord-262253-3ovqhypt	370	11	of	of	IN
cord-262253-3ovqhypt	370	12	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	370	13	's	's	POS
cord-262253-3ovqhypt	370	14	disease	disease	NN
cord-262253-3ovqhypt	370	15	Anti	Anti	NNP
cord-262253-3ovqhypt	370	16	-	-	NNP
cord-262253-3ovqhypt	370	17	Viral	Viral	NNP
cord-262253-3ovqhypt	370	18	Properties	Properties	NNPS
cord-262253-3ovqhypt	370	19	of	of	IN
cord-262253-3ovqhypt	370	20	Amyloid	Amyloid	NNP
cord-262253-3ovqhypt	370	21	-	-	HYPH
cord-262253-3ovqhypt	370	22	β	β	NN
cord-262253-3ovqhypt	370	23	Peptides	Peptides	NNP
cord-262253-3ovqhypt	370	24	Acyclovir	Acyclovir	NNP
cord-262253-3ovqhypt	370	25	:	:	:
cord-262253-3ovqhypt	370	26	Mechanism	mechanism	NN
cord-262253-3ovqhypt	370	27	of	of	IN
cord-262253-3ovqhypt	370	28	action	action	NN
cord-262253-3ovqhypt	370	29	,	,	,
cord-262253-3ovqhypt	370	30	pharmacokinetics	pharmacokinetic	NNS
cord-262253-3ovqhypt	370	31	,	,	,
cord-262253-3ovqhypt	370	32	safety	safety	NN
cord-262253-3ovqhypt	370	33	and	and	CC
cord-262253-3ovqhypt	370	34	clinical	clinical	JJ
cord-262253-3ovqhypt	370	35	applications	application	NNS
cord-262253-3ovqhypt	371	1	Antivirals	antiviral	NNS
cord-262253-3ovqhypt	371	2	reduce	reduce	VBP
cord-262253-3ovqhypt	371	3	the	the	DT
cord-262253-3ovqhypt	371	4	formation	formation	NN
cord-262253-3ovqhypt	371	5	of	of	IN
cord-262253-3ovqhypt	371	6	key	key	JJ
cord-262253-3ovqhypt	371	7	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	371	8	's	's	POS
cord-262253-3ovqhypt	371	9	disease	disease	NN
cord-262253-3ovqhypt	371	10	molecules	molecule	NNS
cord-262253-3ovqhypt	371	11	in	in	IN
cord-262253-3ovqhypt	371	12	cell	cell	NN
cord-262253-3ovqhypt	371	13	cultures	culture	NNS
cord-262253-3ovqhypt	371	14	acutely	acutely	RB
cord-262253-3ovqhypt	371	15	infected	infect	VBN
cord-262253-3ovqhypt	371	16	with	with	IN
cord-262253-3ovqhypt	371	17	herpes	herpes	NN
cord-262253-3ovqhypt	371	18	simplex	simplex	NNP
cord-262253-3ovqhypt	371	19	virus	virus	NN
cord-262253-3ovqhypt	371	20	type	type	NN
cord-262253-3ovqhypt	371	21	1	1	CD
cord-262253-3ovqhypt	371	22	Neuronal	neuronal	JJ
cord-262253-3ovqhypt	371	23	cytoskeletal	cytoskeletal	JJ
cord-262253-3ovqhypt	371	24	dynamic	dynamic	JJ
cord-262253-3ovqhypt	371	25	modification	modification	NN
cord-262253-3ovqhypt	371	26	and	and	CC
cord-262253-3ovqhypt	371	27	neurodegeneration	neurodegeneration	NN
cord-262253-3ovqhypt	371	28	induced	induce	VBN
cord-262253-3ovqhypt	371	29	by	by	IN
cord-262253-3ovqhypt	371	30	infection	infection	NN
cord-262253-3ovqhypt	371	31	with	with	IN
cord-262253-3ovqhypt	371	32	herpes	herpes	NNP
cord-262253-3ovqhypt	371	33	simplex	simplex	NNP
cord-262253-3ovqhypt	371	34	virus	virus	NN
cord-262253-3ovqhypt	371	35	type	type	NN
cord-262253-3ovqhypt	371	36	1	1	CD
cord-262253-3ovqhypt	371	37	.	.	.
cord-262253-3ovqhypt	372	1	J.	J.	NNP
cord-262253-3ovqhypt	372	2	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	372	3	's	's	POS
cord-262253-3ovqhypt	372	4	Dis	Dis	NNP
cord-262253-3ovqhypt	373	1	The	the	DT
cord-262253-3ovqhypt	373	2	combination	combination	NN
cord-262253-3ovqhypt	373	3	of	of	IN
cord-262253-3ovqhypt	373	4	acyclovir	acyclovir	NN
cord-262253-3ovqhypt	373	5	and	and	CC
cord-262253-3ovqhypt	373	6	dexamethasone	dexamethasone	NN
cord-262253-3ovqhypt	373	7	protects	protect	VBZ
cord-262253-3ovqhypt	373	8	against	against	IN
cord-262253-3ovqhypt	373	9	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	373	10	's	's	POS
cord-262253-3ovqhypt	373	11	disease	disease	NN
cord-262253-3ovqhypt	373	12	-	-	HYPH
cord-262253-3ovqhypt	373	13	related	relate	VBN
cord-262253-3ovqhypt	373	14	cognitive	cognitive	JJ
cord-262253-3ovqhypt	373	15	impairments	impairment	NNS
cord-262253-3ovqhypt	373	16	in	in	IN
cord-262253-3ovqhypt	373	17	mice	mouse	NNS
cord-262253-3ovqhypt	373	18	Antiherpes	Antiherpes	NNP
cord-262253-3ovqhypt	373	19	virus	virus	NN
cord-262253-3ovqhypt	373	20	-	-	HYPH
cord-262253-3ovqhypt	373	21	specific	specific	JJ
cord-262253-3ovqhypt	373	22	treatment	treatment	NN
cord-262253-3ovqhypt	373	23	and	and	CC
cord-262253-3ovqhypt	373	24	cognition	cognition	NN
cord-262253-3ovqhypt	373	25	in	in	IN
cord-262253-3ovqhypt	373	26	schizophrenia	schizophrenia	NNP
cord-262253-3ovqhypt	373	27	:	:	:
cord-262253-3ovqhypt	374	1	A	a	DT
cord-262253-3ovqhypt	374	2	test	test	NN
cord-262253-3ovqhypt	374	3	-	-	HYPH
cord-262253-3ovqhypt	374	4	of	of	IN
cord-262253-3ovqhypt	374	5	-	-	HYPH
cord-262253-3ovqhypt	374	6	concept	concept	NN
cord-262253-3ovqhypt	374	7	randomized	randomize	VBN
cord-262253-3ovqhypt	374	8	double	double	JJ
cord-262253-3ovqhypt	374	9	-	-	HYPH
cord-262253-3ovqhypt	374	10	blind	blind	JJ
cord-262253-3ovqhypt	374	11	placebo	placebo	NN
cord-262253-3ovqhypt	374	12	-	-	HYPH
cord-262253-3ovqhypt	374	13	controlled	control	VBN
cord-262253-3ovqhypt	374	14	trial	trial	NN
cord-262253-3ovqhypt	374	15	Antiviral	antiviral	JJ
cord-262253-3ovqhypt	374	16	therapy	therapy	NN
cord-262253-3ovqhypt	374	17	:	:	:
cord-262253-3ovqhypt	375	1	Valacyclovir	Valacyclovir	NNP
cord-262253-3ovqhypt	375	2	Treatment	Treatment	NNP
cord-262253-3ovqhypt	375	3	of	of	IN
cord-262253-3ovqhypt	375	4	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	375	5	's	's	POS
cord-262253-3ovqhypt	375	6	Disease	Disease	NNP
cord-262253-3ovqhypt	375	7	(	(	-LRB-
cord-262253-3ovqhypt	375	8	VALAD	VALAD	NNP
cord-262253-3ovqhypt	375	9	)	)	-RRB-
cord-262253-3ovqhypt	376	1	Trial	trial	NN
cord-262253-3ovqhypt	376	2	:	:	:
cord-262253-3ovqhypt	376	3	Protocol	protocol	NN
cord-262253-3ovqhypt	376	4	for	for	IN
cord-262253-3ovqhypt	376	5	a	a	DT
cord-262253-3ovqhypt	376	6	randomised	randomised	JJ
cord-262253-3ovqhypt	376	7	,	,	,
cord-262253-3ovqhypt	376	8	double	double	JJ
cord-262253-3ovqhypt	376	9	-	-	HYPH
cord-262253-3ovqhypt	376	10	blind	blind	JJ
cord-262253-3ovqhypt	376	11	,	,	,
cord-262253-3ovqhypt	376	12	placebo	placebo	NN
cord-262253-3ovqhypt	376	13	-	-	HYPH
cord-262253-3ovqhypt	376	14	controlled	control	VBN
cord-262253-3ovqhypt	376	15	,	,	,
cord-262253-3ovqhypt	376	16	treatment	treatment	NN
cord-262253-3ovqhypt	376	17	trial	trial	NN
cord-262253-3ovqhypt	377	1	The	the	DT
cord-262253-3ovqhypt	377	2	helicase	helicase	NN
cord-262253-3ovqhypt	377	3	-	-	HYPH
cord-262253-3ovqhypt	377	4	primase	primase	JJ
cord-262253-3ovqhypt	377	5	inhibitor	inhibitor	NN
cord-262253-3ovqhypt	377	6	BAY	BAY	NNP
cord-262253-3ovqhypt	377	7	57	57	CD
cord-262253-3ovqhypt	377	8	-	-	SYM
cord-262253-3ovqhypt	377	9	1293	1293	CD
cord-262253-3ovqhypt	377	10	reduces	reduce	VBZ
cord-262253-3ovqhypt	377	11	the	the	DT
cord-262253-3ovqhypt	377	12	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	377	13	's	's	POS
cord-262253-3ovqhypt	377	14	disease	disease	NN
cord-262253-3ovqhypt	377	15	-	-	HYPH
cord-262253-3ovqhypt	377	16	related	relate	VBN
cord-262253-3ovqhypt	377	17	molecules	molecule	NNS
cord-262253-3ovqhypt	377	18	induced	induce	VBN
cord-262253-3ovqhypt	377	19	by	by	IN
cord-262253-3ovqhypt	377	20	herpes	herpes	NNP
cord-262253-3ovqhypt	377	21	simplex	simplex	NNP
cord-262253-3ovqhypt	377	22	virus	virus	NN
cord-262253-3ovqhypt	377	23	type	type	NN
cord-262253-3ovqhypt	377	24	1	1	CD
cord-262253-3ovqhypt	377	25	Superior	superior	JJ
cord-262253-3ovqhypt	377	26	efficacy	efficacy	NN
cord-262253-3ovqhypt	377	27	of	of	IN
cord-262253-3ovqhypt	377	28	helicase	helicase	NN
cord-262253-3ovqhypt	377	29	-	-	HYPH
cord-262253-3ovqhypt	377	30	primase	primase	JJ
cord-262253-3ovqhypt	377	31	inhibitor	inhibitor	NN
cord-262253-3ovqhypt	377	32	BAY	BAY	NNP
cord-262253-3ovqhypt	377	33	57	57	CD
cord-262253-3ovqhypt	377	34	-	-	SYM
cord-262253-3ovqhypt	377	35	1293	1293	CD
cord-262253-3ovqhypt	377	36	for	for	IN
cord-262253-3ovqhypt	377	37	herpes	herpes	NN
cord-262253-3ovqhypt	377	38	infection	infection	NN
cord-262253-3ovqhypt	377	39	and	and	CC
cord-262253-3ovqhypt	377	40	latency	latency	NN
cord-262253-3ovqhypt	377	41	in	in	IN
cord-262253-3ovqhypt	377	42	the	the	DT
cord-262253-3ovqhypt	377	43	guinea	guinea	NN
cord-262253-3ovqhypt	377	44	pig	pig	NN
cord-262253-3ovqhypt	377	45	model	model	NN
cord-262253-3ovqhypt	377	46	of	of	IN
cord-262253-3ovqhypt	377	47	human	human	JJ
cord-262253-3ovqhypt	377	48	genital	genital	JJ
cord-262253-3ovqhypt	377	49	herpes	herpes	NN
cord-262253-3ovqhypt	377	50	disease	disease	NN
cord-262253-3ovqhypt	378	1	Potent	potent	JJ
cord-262253-3ovqhypt	378	2	in	in	IN
cord-262253-3ovqhypt	378	3	vivo	vivo	NN
cord-262253-3ovqhypt	378	4	antiviral	antiviral	JJ
cord-262253-3ovqhypt	378	5	activity	activity	NN
cord-262253-3ovqhypt	378	6	of	of	IN
cord-262253-3ovqhypt	378	7	the	the	DT
cord-262253-3ovqhypt	378	8	herpes	herpes	NNP
cord-262253-3ovqhypt	378	9	simplex	simplex	NNP
cord-262253-3ovqhypt	378	10	virus	virus	NN
cord-262253-3ovqhypt	378	11	primase	primase	NN
cord-262253-3ovqhypt	378	12	-	-	HYPH
cord-262253-3ovqhypt	378	13	helicase	helicase	NN
cord-262253-3ovqhypt	378	14	inhibitor	inhibitor	NN
cord-262253-3ovqhypt	379	1	BAY	BAY	NNP
cord-262253-3ovqhypt	379	2	57	57	CD
cord-262253-3ovqhypt	379	3	-	-	SYM
cord-262253-3ovqhypt	379	4	1293	1293	CD
cord-262253-3ovqhypt	379	5	Helicase	Helicase	NNP
cord-262253-3ovqhypt	379	6	primase	primase	NN
cord-262253-3ovqhypt	379	7	:	:	:
cord-262253-3ovqhypt	379	8	Targeting	target	VBG
cord-262253-3ovqhypt	379	9	the	the	DT
cord-262253-3ovqhypt	379	10	Achilles	Achilles	NNP
cord-262253-3ovqhypt	379	11	heel	heel	NN
cord-262253-3ovqhypt	379	12	of	of	IN
cord-262253-3ovqhypt	379	13	herpes	herpes	NN
cord-262253-3ovqhypt	379	14	simplex	simplex	NN
cord-262253-3ovqhypt	379	15	viruses	virus	NNS
cord-262253-3ovqhypt	380	1	New	new	JJ
cord-262253-3ovqhypt	380	2	helicase	helicase	NN
cord-262253-3ovqhypt	380	3	-	-	HYPH
cord-262253-3ovqhypt	380	4	primase	primase	NN
cord-262253-3ovqhypt	380	5	inhibitors	inhibitor	NNS
cord-262253-3ovqhypt	380	6	as	as	IN
cord-262253-3ovqhypt	380	7	drug	drug	NN
cord-262253-3ovqhypt	380	8	candidates	candidate	NNS
cord-262253-3ovqhypt	380	9	for	for	IN
cord-262253-3ovqhypt	380	10	the	the	DT
cord-262253-3ovqhypt	380	11	treatment	treatment	NN
cord-262253-3ovqhypt	380	12	of	of	IN
cord-262253-3ovqhypt	380	13	herpes	herpes	NN
cord-262253-3ovqhypt	380	14	simplex	simplex	NNP
cord-262253-3ovqhypt	380	15	disease	disease	NN
cord-262253-3ovqhypt	380	16	Mechanism	Mechanism	NNP
cord-262253-3ovqhypt	380	17	of	of	IN
cord-262253-3ovqhypt	380	18	action	action	NN
cord-262253-3ovqhypt	380	19	of	of	IN
cord-262253-3ovqhypt	380	20	the	the	DT
cord-262253-3ovqhypt	380	21	antiherpesvirus	antiherpesvirus	NNP
cord-262253-3ovqhypt	381	1	biflavone	biflavone	NNP
cord-262253-3ovqhypt	382	1	ginkgetin	ginkgetin	NNP
cord-262253-3ovqhypt	382	2	Anti	Anti	NNP
cord-262253-3ovqhypt	382	3	-	-	JJ
cord-262253-3ovqhypt	382	4	influenza	influenza	JJ
cord-262253-3ovqhypt	382	5	virus	virus	NN
cord-262253-3ovqhypt	382	6	activity	activity	NN
cord-262253-3ovqhypt	382	7	of	of	IN
cord-262253-3ovqhypt	382	8	biflavonoids	biflavonoid	NNS
cord-262253-3ovqhypt	382	9	Ginkgolic	Ginkgolic	NNP
cord-262253-3ovqhypt	382	10	acid	acid	NN
cord-262253-3ovqhypt	382	11	inhibits	inhibit	VBZ
cord-262253-3ovqhypt	382	12	fusion	fusion	NN
cord-262253-3ovqhypt	382	13	of	of	IN
cord-262253-3ovqhypt	382	14	enveloped	envelop	VBN
cord-262253-3ovqhypt	382	15	viruses	virus	NNS
cord-262253-3ovqhypt	382	16	Ginkgolic	Ginkgolic	NNP
cord-262253-3ovqhypt	382	17	acids	acid	NNS
cord-262253-3ovqhypt	382	18	and	and	CC
cord-262253-3ovqhypt	382	19	Ginkgo	Ginkgo	NNP
cord-262253-3ovqhypt	382	20	biloba	biloba	NN
cord-262253-3ovqhypt	382	21	extract	extract	NN
cord-262253-3ovqhypt	382	22	inhibit	inhibit	VBP
cord-262253-3ovqhypt	382	23	Escherichia	Escherichia	NNP
cord-262253-3ovqhypt	382	24	coli	coli	NNS
cord-262253-3ovqhypt	382	25	O157	O157	NNP
cord-262253-3ovqhypt	382	26	:	:	:
cord-262253-3ovqhypt	383	1	H7	H7	NNP
cord-262253-3ovqhypt	383	2	and	and	CC
cord-262253-3ovqhypt	383	3	Staphylococcus	Staphylococcus	NNP
cord-262253-3ovqhypt	383	4	aureus	aureus	NN
cord-262253-3ovqhypt	383	5	biofilm	biofilm	NN
cord-262253-3ovqhypt	383	6	formation	formation	NN
cord-262253-3ovqhypt	383	7	Antimicrobial	antimicrobial	JJ
cord-262253-3ovqhypt	383	8	activity	activity	NN
cord-262253-3ovqhypt	383	9	,	,	,
cord-262253-3ovqhypt	383	10	toxicity	toxicity	NN
cord-262253-3ovqhypt	383	11	and	and	CC
cord-262253-3ovqhypt	383	12	selectivity	selectivity	NN
cord-262253-3ovqhypt	383	13	index	index	NN
cord-262253-3ovqhypt	383	14	of	of	IN
cord-262253-3ovqhypt	383	15	two	two	CD
cord-262253-3ovqhypt	383	16	biflavonoids	biflavonoid	NNS
cord-262253-3ovqhypt	383	17	and	and	CC
cord-262253-3ovqhypt	383	18	a	a	DT
cord-262253-3ovqhypt	383	19	flavone	flavone	NN
cord-262253-3ovqhypt	383	20	isolated	isolate	VBN
cord-262253-3ovqhypt	383	21	from	from	IN
cord-262253-3ovqhypt	383	22	Podocarpus	Podocarpus	NNP
cord-262253-3ovqhypt	383	23	henkelii	henkelii	NNP
cord-262253-3ovqhypt	383	24	(	(	-LRB-
cord-262253-3ovqhypt	383	25	Podocarpaceae	Podocarpaceae	NNP
cord-262253-3ovqhypt	383	26	)	)	-RRB-
cord-262253-3ovqhypt	383	27	leaves	leave	VBZ
cord-262253-3ovqhypt	383	28	.	.	.
cord-262253-3ovqhypt	384	1	BMC	BMC	NNP
cord-262253-3ovqhypt	384	2	Complementary	Complementary	NNP
cord-262253-3ovqhypt	384	3	Altern	Altern	NNP
cord-262253-3ovqhypt	384	4	Ginkgetin	Ginkgetin	NNP
cord-262253-3ovqhypt	384	5	Ameliorates	Ameliorates	NNPS
cord-262253-3ovqhypt	384	6	Neuropathological	Neuropathological	NNP
cord-262253-3ovqhypt	384	7	Changes	Changes	NNPS
cord-262253-3ovqhypt	384	8	in	in	IN
cord-262253-3ovqhypt	384	9	APP	app	NN
cord-262253-3ovqhypt	384	10	/	/	SYM
cord-262253-3ovqhypt	384	11	PS1	PS1	NNP
cord-262253-3ovqhypt	384	12	Transgenical	Transgenical	NNP
cord-262253-3ovqhypt	384	13	Mice	Mice	NNP
cord-262253-3ovqhypt	384	14	Model	Model	NNP
cord-262253-3ovqhypt	384	15	Neuroprotective	Neuroprotective	NNP
cord-262253-3ovqhypt	384	16	effects	effect	NNS
cord-262253-3ovqhypt	384	17	of	of	IN
cord-262253-3ovqhypt	384	18	naturally	naturally	RB
cord-262253-3ovqhypt	384	19	occurring	occur	VBG
cord-262253-3ovqhypt	384	20	biflavonoids	biflavonoid	NNS
cord-262253-3ovqhypt	384	21	Inhibitory	inhibitory	JJ
cord-262253-3ovqhypt	384	22	activities	activity	NNS
cord-262253-3ovqhypt	384	23	of	of	IN
cord-262253-3ovqhypt	384	24	biflavonoids	biflavonoid	NNS
cord-262253-3ovqhypt	384	25	against	against	IN
cord-262253-3ovqhypt	384	26	amyloid	amyloid	NN
cord-262253-3ovqhypt	384	27	-	-	HYPH
cord-262253-3ovqhypt	384	28	beta	beta	NN
cord-262253-3ovqhypt	384	29	peptide	peptide	NN
cord-262253-3ovqhypt	384	30	42	42	CD
cord-262253-3ovqhypt	384	31	cytotoxicity	cytotoxicity	NN
cord-262253-3ovqhypt	384	32	in	in	IN
cord-262253-3ovqhypt	384	33	PC-12	PC-12	NNP
cord-262253-3ovqhypt	384	34	cells	cell	VBZ
cord-262253-3ovqhypt	384	35	Doxycycline	Doxycycline	NNP
cord-262253-3ovqhypt	384	36	for	for	IN
cord-262253-3ovqhypt	384	37	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	384	38	's	's	POS
cord-262253-3ovqhypt	384	39	Disease	Disease	NNP
cord-262253-3ovqhypt	384	40	:	:	:
cord-262253-3ovqhypt	384	41	Fighting	fight	VBG
cord-262253-3ovqhypt	384	42	beta	beta	NN
cord-262253-3ovqhypt	384	43	-	-	HYPH
cord-262253-3ovqhypt	384	44	Amyloid	Amyloid	NNP
cord-262253-3ovqhypt	384	45	Oligomers	Oligomers	NNP
cord-262253-3ovqhypt	384	46	and	and	CC
cord-262253-3ovqhypt	384	47	Neuroinflammation	Neuroinflammation	NNP
cord-262253-3ovqhypt	384	48	Interaction	Interaction	NNP
cord-262253-3ovqhypt	384	49	of	of	IN
cord-262253-3ovqhypt	384	50	the	the	DT
cord-262253-3ovqhypt	384	51	anthracycline	anthracycline	JJ
cord-262253-3ovqhypt	384	52	4	4	CD
cord-262253-3ovqhypt	384	53	-iodo-4	-iodo-4	:
cord-262253-3ovqhypt	384	54	-deoxydoxorubicin	-deoxydoxorubicin	NNS
cord-262253-3ovqhypt	384	55	with	with	IN
cord-262253-3ovqhypt	384	56	amyloid	amyloid	NN
cord-262253-3ovqhypt	384	57	fibrils	fibril	NNS
cord-262253-3ovqhypt	384	58	:	:	:
cord-262253-3ovqhypt	385	1	Inhibition	inhibition	NN
cord-262253-3ovqhypt	385	2	of	of	IN
cord-262253-3ovqhypt	385	3	amyloidogenesis	amyloidogenesis	NN
cord-262253-3ovqhypt	385	4	Doxycycline	Doxycycline	NNP
cord-262253-3ovqhypt	385	5	counteracts	counteract	VBZ
cord-262253-3ovqhypt	385	6	neuroinflammation	neuroinflammation	NN
cord-262253-3ovqhypt	385	7	restoring	restore	VBG
cord-262253-3ovqhypt	385	8	memory	memory	NN
cord-262253-3ovqhypt	385	9	in	in	IN
cord-262253-3ovqhypt	385	10	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	385	11	's	's	POS
cord-262253-3ovqhypt	385	12	disease	disease	NN
cord-262253-3ovqhypt	385	13	mouse	mouse	NN
cord-262253-3ovqhypt	385	14	models	model	NNS
cord-262253-3ovqhypt	385	15	Testing	test	VBG
cord-262253-3ovqhypt	385	16	the	the	DT
cord-262253-3ovqhypt	385	17	therapeutic	therapeutic	JJ
cord-262253-3ovqhypt	385	18	potential	potential	NN
cord-262253-3ovqhypt	385	19	of	of	IN
cord-262253-3ovqhypt	385	20	doxycycline	doxycycline	NN
cord-262253-3ovqhypt	385	21	in	in	IN
cord-262253-3ovqhypt	385	22	a	a	DT
cord-262253-3ovqhypt	385	23	Drosophila	Drosophila	NNP
cord-262253-3ovqhypt	385	24	melanogaster	melanogaster	NN
cord-262253-3ovqhypt	385	25	model	model	NN
cord-262253-3ovqhypt	385	26	of	of	IN
cord-262253-3ovqhypt	385	27	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	385	28	disease	disease	NN
cord-262253-3ovqhypt	386	1	The	the	DT
cord-262253-3ovqhypt	386	2	Anti	Anti	NNP
cord-262253-3ovqhypt	386	3	-	-	NNP
cord-262253-3ovqhypt	386	4	Amyloidogenic	Amyloidogenic	NNP
cord-262253-3ovqhypt	386	5	Action	Action	NNP
cord-262253-3ovqhypt	386	6	of	of	IN
cord-262253-3ovqhypt	386	7	Doxycycline	Doxycycline	NNP
cord-262253-3ovqhypt	386	8	:	:	:
cord-262253-3ovqhypt	387	1	A	a	DT
cord-262253-3ovqhypt	387	2	Molecular	Molecular	NNP
cord-262253-3ovqhypt	387	3	Dynamics	Dynamics	NNPS
cord-262253-3ovqhypt	387	4	Study	Study	NNP
cord-262253-3ovqhypt	387	5	on	on	IN
cord-262253-3ovqhypt	387	6	the	the	DT
cord-262253-3ovqhypt	387	7	Interaction	Interaction	NNP
cord-262253-3ovqhypt	387	8	with	with	IN
cord-262253-3ovqhypt	387	9	Abeta42	Abeta42	NNP
cord-262253-3ovqhypt	388	1	A	a	DT
cord-262253-3ovqhypt	388	2	randomized	randomized	JJ
cord-262253-3ovqhypt	388	3	,	,	,
cord-262253-3ovqhypt	388	4	controlled	control	VBN
cord-262253-3ovqhypt	388	5	trial	trial	NN
cord-262253-3ovqhypt	388	6	of	of	IN
cord-262253-3ovqhypt	388	7	doxycycline	doxycycline	NN
cord-262253-3ovqhypt	388	8	and	and	CC
cord-262253-3ovqhypt	388	9	rifampin	rifampin	NN
cord-262253-3ovqhypt	388	10	for	for	IN
cord-262253-3ovqhypt	388	11	patients	patient	NNS
cord-262253-3ovqhypt	388	12	with	with	IN
cord-262253-3ovqhypt	388	13	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	388	14	's	's	POS
cord-262253-3ovqhypt	388	15	disease	disease	NN
cord-262253-3ovqhypt	389	1	A	a	DT
cord-262253-3ovqhypt	389	2	multicenter	multicenter	NN
cord-262253-3ovqhypt	389	3	,	,	,
cord-262253-3ovqhypt	389	4	blinded	blinded	JJ
cord-262253-3ovqhypt	389	5	,	,	,
cord-262253-3ovqhypt	389	6	randomized	randomized	JJ
cord-262253-3ovqhypt	389	7	,	,	,
cord-262253-3ovqhypt	389	8	factorial	factorial	NNP
cord-262253-3ovqhypt	389	9	controlled	control	VBN
cord-262253-3ovqhypt	389	10	trial	trial	NN
cord-262253-3ovqhypt	389	11	of	of	IN
cord-262253-3ovqhypt	389	12	doxycycline	doxycycline	NN
cord-262253-3ovqhypt	389	13	and	and	CC
cord-262253-3ovqhypt	389	14	rifampin	rifampin	NN
cord-262253-3ovqhypt	389	15	for	for	IN
cord-262253-3ovqhypt	389	16	treatment	treatment	NN
cord-262253-3ovqhypt	389	17	of	of	IN
cord-262253-3ovqhypt	389	18	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	389	19	's	's	POS
cord-262253-3ovqhypt	389	20	disease	disease	NN
cord-262253-3ovqhypt	389	21	:	:	:
cord-262253-3ovqhypt	389	22	The	the	DT
cord-262253-3ovqhypt	389	23	DARAD	DARAD	NNP
cord-262253-3ovqhypt	389	24	trial	trial	NN
cord-262253-3ovqhypt	389	25	An	An	NNP
cord-262253-3ovqhypt	389	26	Investigation	Investigation	NNP
cord-262253-3ovqhypt	389	27	on	on	IN
cord-262253-3ovqhypt	389	28	in	in	IN
cord-262253-3ovqhypt	389	29	vitro	vitro	FW
cord-262253-3ovqhypt	389	30	and	and	CC
cord-262253-3ovqhypt	389	31	in	in	IN
cord-262253-3ovqhypt	389	32	vivo	vivo	NNP
cord-262253-3ovqhypt	389	33	Antimicrobial	Antimicrobial	NNP
cord-262253-3ovqhypt	389	34	Properties	Properties	NNPS
cord-262253-3ovqhypt	389	35	of	of	IN
cord-262253-3ovqhypt	389	36	the	the	DT
cord-262253-3ovqhypt	389	37	Antidepressant	Antidepressant	NNP
cord-262253-3ovqhypt	389	38	:	:	:
cord-262253-3ovqhypt	389	39	Amitriptyline	Amitriptyline	NNP
cord-262253-3ovqhypt	389	40	Hydrochloride	Hydrochloride	NNP
cord-262253-3ovqhypt	389	41	Unintended	unintended	JJ
cord-262253-3ovqhypt	389	42	effects	effect	NNS
cord-262253-3ovqhypt	389	43	of	of	IN
cord-262253-3ovqhypt	389	44	cardiovascular	cardiovascular	JJ
cord-262253-3ovqhypt	389	45	drugs	drug	NNS
cord-262253-3ovqhypt	389	46	on	on	IN
cord-262253-3ovqhypt	389	47	the	the	DT
cord-262253-3ovqhypt	389	48	pathogenesis	pathogenesis	NN
cord-262253-3ovqhypt	389	49	of	of	IN
cord-262253-3ovqhypt	389	50	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	389	51	's	's	POS
cord-262253-3ovqhypt	389	52	disease	disease	NN
cord-262253-3ovqhypt	390	1	RIFAMPICIN	RIFAMPICIN	NNP
cord-262253-3ovqhypt	390	2	:	:	:
cord-262253-3ovqhypt	391	1	An	an	DT
cord-262253-3ovqhypt	391	2	antibiotic	antibiotic	NN
cord-262253-3ovqhypt	391	3	with	with	IN
cord-262253-3ovqhypt	391	4	brain	brain	NN
cord-262253-3ovqhypt	391	5	protective	protective	JJ
cord-262253-3ovqhypt	391	6	function	function	NN
cord-262253-3ovqhypt	391	7	Therapeutic	therapeutic	JJ
cord-262253-3ovqhypt	391	8	role	role	NN
cord-262253-3ovqhypt	391	9	of	of	IN
cord-262253-3ovqhypt	391	10	rifampicin	rifampicin	NN
cord-262253-3ovqhypt	391	11	in	in	IN
cord-262253-3ovqhypt	391	12	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	391	13	's	's	POS
cord-262253-3ovqhypt	391	14	disease	disease	NN
cord-262253-3ovqhypt	391	15	Rifampicin	Rifampicin	NNP
cord-262253-3ovqhypt	391	16	and	and	CC
cord-262253-3ovqhypt	391	17	Parkinson	Parkinson	NNP
cord-262253-3ovqhypt	391	18	's	's	POS
cord-262253-3ovqhypt	391	19	disease	disease	NN
cord-262253-3ovqhypt	391	20	Rifampicin	Rifampicin	NNP
cord-262253-3ovqhypt	391	21	prevents	prevent	VBZ
cord-262253-3ovqhypt	391	22	the	the	DT
cord-262253-3ovqhypt	391	23	aggregation	aggregation	NN
cord-262253-3ovqhypt	391	24	and	and	CC
cord-262253-3ovqhypt	391	25	neurotoxicity	neurotoxicity	NN
cord-262253-3ovqhypt	391	26	of	of	IN
cord-262253-3ovqhypt	391	27	amyloid	amyloid	NN
cord-262253-3ovqhypt	391	28	beta	beta	NN
cord-262253-3ovqhypt	391	29	protein	protein	NN
cord-262253-3ovqhypt	391	30	in	in	IN
cord-262253-3ovqhypt	391	31	vitro	vitro	FW
cord-262253-3ovqhypt	391	32	Inhibition	inhibition	NN
cord-262253-3ovqhypt	391	33	of	of	IN
cord-262253-3ovqhypt	391	34	amyloid	amyloid	NN
cord-262253-3ovqhypt	391	35	beta	beta	NN
cord-262253-3ovqhypt	391	36	protein	protein	NN
cord-262253-3ovqhypt	391	37	aggregation	aggregation	NN
cord-262253-3ovqhypt	391	38	and	and	CC
cord-262253-3ovqhypt	391	39	neurotoxicity	neurotoxicity	NN
cord-262253-3ovqhypt	391	40	by	by	IN
cord-262253-3ovqhypt	391	41	rifampicin	rifampicin	NNS
cord-262253-3ovqhypt	391	42	.	.	.
cord-262253-3ovqhypt	392	1	Its	-PRON-	PRP$
cord-262253-3ovqhypt	392	2	possible	possible	JJ
cord-262253-3ovqhypt	392	3	function	function	NN
cord-262253-3ovqhypt	392	4	as	as	IN
cord-262253-3ovqhypt	392	5	a	a	DT
cord-262253-3ovqhypt	392	6	hydroxyl	hydroxyl	NN
cord-262253-3ovqhypt	392	7	radical	radical	JJ
cord-262253-3ovqhypt	392	8	scavenger	scavenger	NN
cord-262253-3ovqhypt	392	9	Penetration	penetration	NN
cord-262253-3ovqhypt	392	10	of	of	IN
cord-262253-3ovqhypt	392	11	rifampicin	rifampicin	NN
cord-262253-3ovqhypt	392	12	into	into	IN
cord-262253-3ovqhypt	392	13	the	the	DT
cord-262253-3ovqhypt	392	14	brain	brain	NN
cord-262253-3ovqhypt	392	15	tissue	tissue	NN
cord-262253-3ovqhypt	392	16	and	and	CC
cord-262253-3ovqhypt	392	17	cerebral	cerebral	JJ
cord-262253-3ovqhypt	392	18	extracellular	extracellular	JJ
cord-262253-3ovqhypt	392	19	space	space	NN
cord-262253-3ovqhypt	392	20	of	of	IN
cord-262253-3ovqhypt	392	21	rats	rat	NNS
cord-262253-3ovqhypt	393	1	Enhanced	enhanced	JJ
cord-262253-3ovqhypt	393	2	brain	brain	NN
cord-262253-3ovqhypt	393	3	amyloid	amyloid	NN
cord-262253-3ovqhypt	393	4	-	-	HYPH
cord-262253-3ovqhypt	393	5	β	β	NN
cord-262253-3ovqhypt	393	6	clearance	clearance	NN
cord-262253-3ovqhypt	393	7	by	by	IN
cord-262253-3ovqhypt	393	8	rifampicin	rifampicin	NNS
cord-262253-3ovqhypt	393	9	and	and	CC
cord-262253-3ovqhypt	393	10	caffeine	caffeine	NN
cord-262253-3ovqhypt	393	11	as	as	IN
cord-262253-3ovqhypt	393	12	a	a	DT
cord-262253-3ovqhypt	393	13	possible	possible	JJ
cord-262253-3ovqhypt	393	14	protective	protective	JJ
cord-262253-3ovqhypt	393	15	mechanism	mechanism	NN
cord-262253-3ovqhypt	393	16	against	against	IN
cord-262253-3ovqhypt	393	17	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	393	18	's	's	POS
cord-262253-3ovqhypt	393	19	disease	disease	NN
cord-262253-3ovqhypt	393	20	.	.	.
cord-262253-3ovqhypt	394	1	J.	J.	NNP
cord-262253-3ovqhypt	394	2	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	394	3	's	's	POS
cord-262253-3ovqhypt	394	4	Dis	Dis	NNP
cord-262253-3ovqhypt	394	5	Rifampicin	Rifampicin	NNP
cord-262253-3ovqhypt	394	6	is	be	VBZ
cord-262253-3ovqhypt	394	7	a	a	DT
cord-262253-3ovqhypt	394	8	candidate	candidate	NN
cord-262253-3ovqhypt	394	9	preventive	preventive	JJ
cord-262253-3ovqhypt	394	10	medicine	medicine	NN
cord-262253-3ovqhypt	394	11	against	against	IN
cord-262253-3ovqhypt	394	12	amyloid	amyloid	NN
cord-262253-3ovqhypt	394	13	-	-	HYPH
cord-262253-3ovqhypt	394	14	β	β	NN
cord-262253-3ovqhypt	394	15	and	and	CC
cord-262253-3ovqhypt	394	16	tau	tau	NNP
cord-262253-3ovqhypt	394	17	oligomers	oligomer	NNS
cord-262253-3ovqhypt	395	1	Intranasal	intranasal	NN
cord-262253-3ovqhypt	395	2	rifampicin	rifampicin	NNS
cord-262253-3ovqhypt	395	3	for	for	IN
cord-262253-3ovqhypt	395	4	Alzheimer	Alzheimer	NNP
cord-262253-3ovqhypt	395	5	's	's	POS
cord-262253-3ovqhypt	395	6	disease	disease	NN
cord-262253-3ovqhypt	395	7	prevention	prevention	NN
cord-262253-3ovqhypt	395	8	Gingipains	Gingipains	NNP
cord-262253-3ovqhypt	395	9	from	from	IN
cord-262253-3ovqhypt	395	10	Porphyromonas	Porphyromonas	NNP
cord-262253-3ovqhypt	395	11	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	395	12	-	-	HYPH
cord-262253-3ovqhypt	395	13	Complex	complex	JJ
cord-262253-3ovqhypt	395	14	domain	domain	NN
cord-262253-3ovqhypt	395	15	structures	structure	NNS
cord-262253-3ovqhypt	395	16	confer	confer	VBP
cord-262253-3ovqhypt	395	17	diverse	diverse	JJ
cord-262253-3ovqhypt	395	18	functions	function	NNS
cord-262253-3ovqhypt	395	19	Molecular	molecular	JJ
cord-262253-3ovqhypt	395	20	genetics	genetic	NNS
cord-262253-3ovqhypt	395	21	and	and	CC
cord-262253-3ovqhypt	395	22	nomenclature	nomenclature	NN
cord-262253-3ovqhypt	395	23	of	of	IN
cord-262253-3ovqhypt	395	24	proteases	protease	NNS
cord-262253-3ovqhypt	395	25	of	of	IN
cord-262253-3ovqhypt	395	26	Porphyromonas	Porphyromonas	NNP
cord-262253-3ovqhypt	395	27	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	395	28	Dichotomy	Dichotomy	NNP
cord-262253-3ovqhypt	395	29	of	of	IN
cord-262253-3ovqhypt	395	30	gingipains	gingipains	NNP
cord-262253-3ovqhypt	395	31	action	action	NN
cord-262253-3ovqhypt	395	32	as	as	IN
cord-262253-3ovqhypt	395	33	virulence	virulence	NN
cord-262253-3ovqhypt	395	34	factors	factor	NNS
cord-262253-3ovqhypt	395	35	:	:	:
cord-262253-3ovqhypt	395	36	From	from	IN
cord-262253-3ovqhypt	395	37	cleaving	cleave	VBG
cord-262253-3ovqhypt	395	38	substrates	substrate	NNS
cord-262253-3ovqhypt	395	39	with	with	IN
cord-262253-3ovqhypt	395	40	the	the	DT
cord-262253-3ovqhypt	395	41	precision	precision	NN
cord-262253-3ovqhypt	395	42	of	of	IN
cord-262253-3ovqhypt	395	43	a	a	DT
cord-262253-3ovqhypt	395	44	surgeon	surgeon	NN
cord-262253-3ovqhypt	395	45	's	's	POS
cord-262253-3ovqhypt	395	46	knife	knife	NN
cord-262253-3ovqhypt	395	47	to	to	IN
cord-262253-3ovqhypt	395	48	a	a	DT
cord-262253-3ovqhypt	395	49	meat	meat	NN
cord-262253-3ovqhypt	395	50	chopper	chopper	NN
cord-262253-3ovqhypt	395	51	-	-	HYPH
cord-262253-3ovqhypt	395	52	like	like	JJ
cord-262253-3ovqhypt	395	53	brutal	brutal	JJ
cord-262253-3ovqhypt	395	54	degradation	degradation	NN
cord-262253-3ovqhypt	395	55	of	of	IN
cord-262253-3ovqhypt	395	56	proteins	protein	NNS
cord-262253-3ovqhypt	395	57	Role	role	NN
cord-262253-3ovqhypt	395	58	of	of	IN
cord-262253-3ovqhypt	395	59	bacterial	bacterial	JJ
cord-262253-3ovqhypt	395	60	proteinases	proteinase	NNS
cord-262253-3ovqhypt	395	61	in	in	IN
cord-262253-3ovqhypt	395	62	matrix	matrix	NN
cord-262253-3ovqhypt	395	63	destruction	destruction	NN
cord-262253-3ovqhypt	395	64	and	and	CC
cord-262253-3ovqhypt	395	65	modulation	modulation	NN
cord-262253-3ovqhypt	395	66	of	of	IN
cord-262253-3ovqhypt	395	67	host	host	NN
cord-262253-3ovqhypt	395	68	responses	response	NNS
cord-262253-3ovqhypt	395	69	Cleavage	Cleavage	NNP
cord-262253-3ovqhypt	395	70	of	of	IN
cord-262253-3ovqhypt	395	71	the	the	DT
cord-262253-3ovqhypt	395	72	human	human	JJ
cord-262253-3ovqhypt	395	73	C5A	c5a	NN
cord-262253-3ovqhypt	395	74	receptor	receptor	NN
cord-262253-3ovqhypt	395	75	by	by	IN
cord-262253-3ovqhypt	395	76	proteinases	proteinases	NNP
cord-262253-3ovqhypt	395	77	derived	derive	VBN
cord-262253-3ovqhypt	395	78	from	from	IN
cord-262253-3ovqhypt	395	79	Porphyromonas	Porphyromonas	NNP
cord-262253-3ovqhypt	395	80	gingivalis	gingivalis	NNP
cord-262253-3ovqhypt	395	81	:	:	:
cord-262253-3ovqhypt	395	82	Cleavage	cleavage	NN
cord-262253-3ovqhypt	395	83	of	of	IN
cord-262253-3ovqhypt	395	84	leukocyte	leukocyte	NN
cord-262253-3ovqhypt	395	85	C5a	C5a	NNP
cord-262253-3ovqhypt	395	86	receptor	receptor	NN
cord-262253-3ovqhypt	395	87	Treatment	Treatment	NNP
cord-262253-3ovqhypt	395	88	of	of	IN
cord-262253-3ovqhypt	395	89	Porphyromonas	Porphyromonas	NNP
cord-262253-3ovqhypt	395	90	gulae	gulae	VBZ
cord-262253-3ovqhypt	395	91	infection	infection	NN
cord-262253-3ovqhypt	395	92	and	and	CC
cord-262253-3ovqhypt	395	93	downstream	downstream	JJ
cord-262253-3ovqhypt	395	94	pathology	pathology	NN
cord-262253-3ovqhypt	395	95	in	in	IN
cord-262253-3ovqhypt	395	96	the	the	DT
cord-262253-3ovqhypt	395	97	aged	aged	JJ
cord-262253-3ovqhypt	395	98	dog	dog	NN
cord-262253-3ovqhypt	395	99	by	by	IN
cord-262253-3ovqhypt	395	100	lysine	lysine	NN
cord-262253-3ovqhypt	395	101	-	-	HYPH
cord-262253-3ovqhypt	395	102	gingipain	gingipain	JJ
cord-262253-3ovqhypt	395	103	inhibitor	inhibitor	NN
cord-262253-3ovqhypt	395	104	COR388	COR388	NNP
cord-262253-3ovqhypt	395	105	Cefepime	Cefepime	NNP
cord-262253-3ovqhypt	395	106	-	-	HYPH
cord-262253-3ovqhypt	395	107	induced	induce	VBN
cord-262253-3ovqhypt	395	108	neurotoxicity	neurotoxicity	NN
cord-262253-3ovqhypt	395	109	:	:	:
cord-262253-3ovqhypt	395	110	A	a	DT
cord-262253-3ovqhypt	395	111	systematic	systematic	JJ
cord-262253-3ovqhypt	395	112	review	review	NN