id sid tid token lemma pos cord-266988-72uvawth 1 1 key key NN cord-266988-72uvawth 1 2 : : : cord-266988-72uvawth 2 1 cord-266988 cord-266988 VB cord-266988-72uvawth 2 2 - - HYPH cord-266988-72uvawth 2 3 72uvawth 72uvawth CD cord-266988-72uvawth 2 4 authors author NNS cord-266988-72uvawth 2 5 : : : cord-266988-72uvawth 2 6 Barth Barth NNP cord-266988-72uvawth 2 7 , , , cord-266988-72uvawth 2 8 Rolf Rolf NNP cord-266988-72uvawth 2 9 F. F. NNP cord-266988-72uvawth 2 10 ; ; : cord-266988-72uvawth 2 11 Buja Buja NNP cord-266988-72uvawth 2 12 , , , cord-266988-72uvawth 2 13 L. L. NNP cord-266988-72uvawth 2 14 Maximillian Maximillian NNP cord-266988-72uvawth 2 15 ; ; : cord-266988-72uvawth 2 16 Parwani Parwani NNP cord-266988-72uvawth 2 17 , , , cord-266988-72uvawth 2 18 Anil Anil NNP cord-266988-72uvawth 2 19 V. V. NNP cord-266988-72uvawth 2 20 title title NN cord-266988-72uvawth 2 21 : : : cord-266988-72uvawth 3 1 The the DT cord-266988-72uvawth 3 2 spectrum spectrum NN cord-266988-72uvawth 3 3 of of IN cord-266988-72uvawth 3 4 pathological pathological JJ cord-266988-72uvawth 3 5 findings finding NNS cord-266988-72uvawth 3 6 in in IN cord-266988-72uvawth 3 7 coronavirus coronavirus NN cord-266988-72uvawth 3 8 disease disease NN cord-266988-72uvawth 3 9 ( ( -LRB- cord-266988-72uvawth 3 10 COVID-19 COVID-19 NNP cord-266988-72uvawth 3 11 ) ) -RRB- cord-266988-72uvawth 3 12 and and CC cord-266988-72uvawth 3 13 the the DT cord-266988-72uvawth 3 14 pathogenesis pathogenesis NN cord-266988-72uvawth 3 15 of of IN cord-266988-72uvawth 3 16 SARS SARS NNP cord-266988-72uvawth 3 17 - - HYPH cord-266988-72uvawth 3 18 CoV-2 CoV-2 NNP cord-266988-72uvawth 3 19 date date NN cord-266988-72uvawth 3 20 : : : cord-266988-72uvawth 3 21 2020 2020 CD cord-266988-72uvawth 3 22 - - HYPH cord-266988-72uvawth 3 23 07 07 CD cord-266988-72uvawth 3 24 - - SYM cord-266988-72uvawth 3 25 14 14 CD cord-266988-72uvawth 3 26 journal journal NN cord-266988-72uvawth 3 27 : : : cord-266988-72uvawth 4 1 Diagn Diagn NNP cord-266988-72uvawth 4 2 Pathol Pathol NNP cord-266988-72uvawth 4 3 DOI DOI NNP cord-266988-72uvawth 4 4 : : : cord-266988-72uvawth 4 5 10.1186 10.1186 CD cord-266988-72uvawth 4 6 / / SYM cord-266988-72uvawth 4 7 s13000 s13000 CD cord-266988-72uvawth 4 8 - - HYPH cord-266988-72uvawth 4 9 020 020 CD cord-266988-72uvawth 4 10 - - HYPH cord-266988-72uvawth 4 11 00999 00999 CD cord-266988-72uvawth 4 12 - - SYM cord-266988-72uvawth 4 13 9 9 CD cord-266988-72uvawth 5 1 sha sha NNP cord-266988-72uvawth 5 2 : : : cord-266988-72uvawth 5 3 f5e08adb6fc82c9d614bab5411036890accc2f3f f5e08adb6fc82c9d614bab5411036890accc2f3f NNP cord-266988-72uvawth 5 4 doc_id doc_id CD cord-266988-72uvawth 6 1 : : : cord-266988-72uvawth 6 2 266988 266988 CD cord-266988-72uvawth 6 3 cord_uid cord_uid NNS cord-266988-72uvawth 6 4 : : : cord-266988-72uvawth 7 1 72uvawth 72uvawth JJ cord-266988-72uvawth 7 2 nan nan NNP cord-266988-72uvawth 8 1 The the DT cord-266988-72uvawth 8 2 coronavirus coronavirus NN cord-266988-72uvawth 8 3 disease disease NN cord-266988-72uvawth 8 4 ( ( -LRB- cord-266988-72uvawth 8 5 COVID-19 COVID-19 NNP cord-266988-72uvawth 8 6 ) ) -RRB- cord-266988-72uvawth 8 7 is be VBZ cord-266988-72uvawth 8 8 now now RB cord-266988-72uvawth 8 9 a a DT cord-266988-72uvawth 8 10 worldwide worldwide JJ cord-266988-72uvawth 8 11 pandemic pandemic NN cord-266988-72uvawth 8 12 and and CC cord-266988-72uvawth 8 13 is be VBZ cord-266988-72uvawth 8 14 the the DT cord-266988-72uvawth 8 15 most most RBS cord-266988-72uvawth 8 16 significant significant JJ cord-266988-72uvawth 8 17 global global JJ cord-266988-72uvawth 8 18 health health NN cord-266988-72uvawth 8 19 crisis crisis NN cord-266988-72uvawth 8 20 of of IN cord-266988-72uvawth 8 21 our -PRON- PRP$ cord-266988-72uvawth 8 22 time time NN cord-266988-72uvawth 8 23 . . . cord-266988-72uvawth 9 1 COVID-19 COVID-19 NNP cord-266988-72uvawth 9 2 disease disease NN cord-266988-72uvawth 9 3 continues continue VBZ cord-266988-72uvawth 9 4 to to TO cord-266988-72uvawth 9 5 present present VB cord-266988-72uvawth 9 6 us -PRON- PRP cord-266988-72uvawth 9 7 with with IN cord-266988-72uvawth 9 8 major major JJ cord-266988-72uvawth 9 9 healthcare healthcare NN cord-266988-72uvawth 9 10 challenges challenge NNS cord-266988-72uvawth 9 11 with with IN cord-266988-72uvawth 9 12 over over IN cord-266988-72uvawth 9 13 8 8 CD cord-266988-72uvawth 9 14 million million CD cord-266988-72uvawth 9 15 cases case NNS cord-266988-72uvawth 9 16 around around IN cord-266988-72uvawth 9 17 the the DT cord-266988-72uvawth 9 18 world world NN cord-266988-72uvawth 9 19 and and CC cord-266988-72uvawth 9 20 still still RB cord-266988-72uvawth 9 21 less less JJR cord-266988-72uvawth 9 22 than than IN cord-266988-72uvawth 9 23 optimal optimal JJ cord-266988-72uvawth 9 24 treatment treatment NN cord-266988-72uvawth 9 25 options option NNS cord-266988-72uvawth 9 26 [ [ -LRB- cord-266988-72uvawth 9 27 1 1 CD cord-266988-72uvawth 9 28 ] ] -RRB- cord-266988-72uvawth 9 29 . . . cord-266988-72uvawth 10 1 The the DT cord-266988-72uvawth 10 2 virus virus NN cord-266988-72uvawth 10 3 initially initially RB cord-266988-72uvawth 10 4 was be VBD cord-266988-72uvawth 10 5 identified identify VBN cord-266988-72uvawth 10 6 in in IN cord-266988-72uvawth 10 7 Wuhan Wuhan NNP cord-266988-72uvawth 10 8 , , , cord-266988-72uvawth 10 9 Hubei Hubei NNP cord-266988-72uvawth 10 10 Province Province NNP cord-266988-72uvawth 10 11 , , , cord-266988-72uvawth 10 12 China China NNP cord-266988-72uvawth 10 13 in in IN cord-266988-72uvawth 10 14 2019 2019 CD cord-266988-72uvawth 10 15 . . . cord-266988-72uvawth 11 1 COVID-19 COVID-19 NNP cord-266988-72uvawth 11 2 disease disease NN cord-266988-72uvawth 11 3 is be VBZ cord-266988-72uvawth 11 4 caused cause VBN cord-266988-72uvawth 11 5 by by IN cord-266988-72uvawth 11 6 a a DT cord-266988-72uvawth 11 7 novel novel JJ cord-266988-72uvawth 11 8 coronavirus coronavirus NN cord-266988-72uvawth 11 9 , , , cord-266988-72uvawth 11 10 which which WDT cord-266988-72uvawth 11 11 has have VBZ cord-266988-72uvawth 11 12 been be VBN cord-266988-72uvawth 11 13 named name VBN cord-266988-72uvawth 11 14 " " `` cord-266988-72uvawth 11 15 Severe severe JJ cord-266988-72uvawth 11 16 Acute acute JJ cord-266988-72uvawth 11 17 Respiratory Respiratory NNP cord-266988-72uvawth 11 18 Syndrome Syndrome NNP cord-266988-72uvawth 11 19 Corona Corona NNP cord-266988-72uvawth 11 20 virus-2 virus-2 NNP cord-266988-72uvawth 11 21 ( ( -LRB- cord-266988-72uvawth 11 22 SARS SARS NNP cord-266988-72uvawth 11 23 - - HYPH cord-266988-72uvawth 11 24 CoV-2 CoV-2 NNP cord-266988-72uvawth 11 25 ) ) -RRB- cord-266988-72uvawth 11 26 " " `` cord-266988-72uvawth 11 27 [ [ -LRB- cord-266988-72uvawth 11 28 2 2 CD cord-266988-72uvawth 11 29 ] ] -RRB- cord-266988-72uvawth 11 30 . . . cord-266988-72uvawth 12 1 COVID-19 COVID-19 NNP cord-266988-72uvawth 12 2 is be VBZ cord-266988-72uvawth 12 3 highly highly RB cord-266988-72uvawth 12 4 transmissible transmissible JJ cord-266988-72uvawth 12 5 among among IN cord-266988-72uvawth 12 6 humans human NNS cord-266988-72uvawth 12 7 and and CC cord-266988-72uvawth 12 8 primarily primarily RB cord-266988-72uvawth 12 9 , , , cord-266988-72uvawth 12 10 but but CC cord-266988-72uvawth 12 11 not not RB cord-266988-72uvawth 12 12 only only RB cord-266988-72uvawth 12 13 , , , cord-266988-72uvawth 12 14 affects affect VBZ cord-266988-72uvawth 12 15 the the DT cord-266988-72uvawth 12 16 lower low JJR cord-266988-72uvawth 12 17 respiratory respiratory JJ cord-266988-72uvawth 12 18 tract tract NN cord-266988-72uvawth 12 19 and and CC cord-266988-72uvawth 12 20 lungs lung NNS cord-266988-72uvawth 12 21 . . . cord-266988-72uvawth 13 1 The the DT cord-266988-72uvawth 13 2 virus virus NN cord-266988-72uvawth 13 3 attaches attach VBZ cord-266988-72uvawth 13 4 to to IN cord-266988-72uvawth 13 5 the the DT cord-266988-72uvawth 13 6 angiotensin angiotensin NN cord-266988-72uvawth 13 7 converting convert VBG cord-266988-72uvawth 13 8 enzyme-2 enzyme-2 NNP cord-266988-72uvawth 13 9 ( ( -LRB- cord-266988-72uvawth 13 10 ACE-2 ACE-2 NNP cord-266988-72uvawth 13 11 ) ) -RRB- cord-266988-72uvawth 13 12 receptor receptor NN cord-266988-72uvawth 13 13 in in IN cord-266988-72uvawth 13 14 order order NN cord-266988-72uvawth 13 15 to to TO cord-266988-72uvawth 13 16 help help VB cord-266988-72uvawth 13 17 enter enter VB cord-266988-72uvawth 13 18 the the DT cord-266988-72uvawth 13 19 target target NN cord-266988-72uvawth 13 20 cell cell NN cord-266988-72uvawth 13 21 by by IN cord-266988-72uvawth 13 22 attaching attach VBG cord-266988-72uvawth 13 23 its -PRON- PRP$ cord-266988-72uvawth 13 24 spike spike NN cord-266988-72uvawth 13 25 - - HYPH cord-266988-72uvawth 13 26 like like JJ cord-266988-72uvawth 13 27 surface surface NN cord-266988-72uvawth 13 28 projections projection NNS cord-266988-72uvawth 13 29 ( ( -LRB- cord-266988-72uvawth 13 30 " " `` cord-266988-72uvawth 13 31 corona corona NN cord-266988-72uvawth 13 32 " " '' cord-266988-72uvawth 13 33 ) ) -RRB- cord-266988-72uvawth 13 34 to to IN cord-266988-72uvawth 13 35 the the DT cord-266988-72uvawth 13 36 receptor receptor NN cord-266988-72uvawth 13 37 . . . cord-266988-72uvawth 14 1 This this DT cord-266988-72uvawth 14 2 receptor receptor NN cord-266988-72uvawth 14 3 is be VBZ cord-266988-72uvawth 14 4 expressed express VBN cord-266988-72uvawth 14 5 on on IN cord-266988-72uvawth 14 6 various various JJ cord-266988-72uvawth 14 7 cell cell NN cord-266988-72uvawth 14 8 types type NNS cord-266988-72uvawth 14 9 such such JJ cord-266988-72uvawth 14 10 as as IN cord-266988-72uvawth 14 11 myocardial myocardial JJ cord-266988-72uvawth 14 12 cells cell NNS cord-266988-72uvawth 14 13 , , , cord-266988-72uvawth 14 14 type type NN cord-266988-72uvawth 14 15 II II NNP cord-266988-72uvawth 14 16 pneumocytes pneumocytes NNPS cord-266988-72uvawth 14 17 , , , cord-266988-72uvawth 14 18 enterocytes enterocyte NNS cord-266988-72uvawth 14 19 and and CC cord-266988-72uvawth 14 20 vascular vascular JJ cord-266988-72uvawth 14 21 endothelium endothelium NN cord-266988-72uvawth 14 22 . . . cord-266988-72uvawth 15 1 Most Most JJS cord-266988-72uvawth 15 2 of of IN cord-266988-72uvawth 15 3 the the DT cord-266988-72uvawth 15 4 symptomatic symptomatic JJ cord-266988-72uvawth 15 5 patients patient NNS cord-266988-72uvawth 15 6 have have VBP cord-266988-72uvawth 15 7 mild mild JJ cord-266988-72uvawth 15 8 flu flu NN cord-266988-72uvawth 15 9 - - HYPH cord-266988-72uvawth 15 10 like like JJ cord-266988-72uvawth 15 11 features feature NNS cord-266988-72uvawth 15 12 but but CC cord-266988-72uvawth 15 13 a a DT cord-266988-72uvawth 15 14 significant significant JJ cord-266988-72uvawth 15 15 subset subset NN cord-266988-72uvawth 15 16 develop develop VBP cord-266988-72uvawth 15 17 a a DT cord-266988-72uvawth 15 18 bronchopneumonia bronchopneumonia NN cord-266988-72uvawth 15 19 , , , cord-266988-72uvawth 15 20 which which WDT cord-266988-72uvawth 15 21 clinically clinically RB cord-266988-72uvawth 15 22 is be VBZ cord-266988-72uvawth 15 23 the the DT cord-266988-72uvawth 15 24 acute acute JJ cord-266988-72uvawth 15 25 respiratory respiratory JJ cord-266988-72uvawth 15 26 distress distress NN cord-266988-72uvawth 15 27 syndrome syndrome NN cord-266988-72uvawth 15 28 ( ( -LRB- cord-266988-72uvawth 15 29 ARDS ARDS NNP cord-266988-72uvawth 15 30 ) ) -RRB- cord-266988-72uvawth 15 31 , , , cord-266988-72uvawth 15 32 and and CC cord-266988-72uvawth 15 33 leads lead VBZ cord-266988-72uvawth 15 34 to to IN cord-266988-72uvawth 15 35 significant significant JJ cord-266988-72uvawth 15 36 morbidity morbidity NN cord-266988-72uvawth 15 37 and and CC cord-266988-72uvawth 15 38 mortality mortality NN cord-266988-72uvawth 15 39 [ [ -LRB- cord-266988-72uvawth 15 40 3 3 CD cord-266988-72uvawth 15 41 ] ] -RRB- cord-266988-72uvawth 15 42 . . . cord-266988-72uvawth 16 1 The the DT cord-266988-72uvawth 16 2 fatality fatality NN cord-266988-72uvawth 16 3 rates rate NNS cord-266988-72uvawth 16 4 of of IN cord-266988-72uvawth 16 5 COVID-19 COVID-19 NNP cord-266988-72uvawth 16 6 are be VBP cord-266988-72uvawth 16 7 highest high JJS cord-266988-72uvawth 16 8 amongst amongst IN cord-266988-72uvawth 16 9 older old JJR cord-266988-72uvawth 16 10 patients patient NNS cord-266988-72uvawth 16 11 with with IN cord-266988-72uvawth 16 12 concomitant concomitant JJ cord-266988-72uvawth 16 13 comorbidities comorbiditie NNS cord-266988-72uvawth 16 14 and/or and/or CC cord-266988-72uvawth 16 15 patients patient NNS cord-266988-72uvawth 16 16 who who WP cord-266988-72uvawth 16 17 are be VBP cord-266988-72uvawth 16 18 immunosuppressed immunosuppressed JJ cord-266988-72uvawth 16 19 [ [ -LRB- cord-266988-72uvawth 16 20 4 4 CD cord-266988-72uvawth 16 21 ] ] -RRB- cord-266988-72uvawth 16 22 . . . cord-266988-72uvawth 17 1 Our -PRON- PRP$ cord-266988-72uvawth 17 2 current current JJ cord-266988-72uvawth 17 3 understanding understanding NN cord-266988-72uvawth 17 4 of of IN cord-266988-72uvawth 17 5 the the DT cord-266988-72uvawth 17 6 pathology pathology NN cord-266988-72uvawth 17 7 and and CC cord-266988-72uvawth 17 8 the the DT cord-266988-72uvawth 17 9 pathogenesis pathogenesis NN cord-266988-72uvawth 17 10 of of IN cord-266988-72uvawth 17 11 COVID-19 COVID-19 NNP cord-266988-72uvawth 17 12 disease disease NN cord-266988-72uvawth 17 13 and and CC cord-266988-72uvawth 17 14 SARS SARS NNP cord-266988-72uvawth 17 15 - - HYPH cord-266988-72uvawth 17 16 CoV-2 CoV-2 NNP cord-266988-72uvawth 17 17 transmission transmission NN cord-266988-72uvawth 17 18 is be VBZ cord-266988-72uvawth 17 19 at at IN cord-266988-72uvawth 17 20 an an DT cord-266988-72uvawth 17 21 early early JJ cord-266988-72uvawth 17 22 stage stage NN cord-266988-72uvawth 17 23 and and CC cord-266988-72uvawth 17 24 much much JJ cord-266988-72uvawth 17 25 still still RB cord-266988-72uvawth 17 26 remains remain VBZ cord-266988-72uvawth 17 27 to to TO cord-266988-72uvawth 17 28 be be VB cord-266988-72uvawth 17 29 learned learn VBN cord-266988-72uvawth 17 30 [ [ -LRB- cord-266988-72uvawth 17 31 5 5 CD cord-266988-72uvawth 17 32 , , , cord-266988-72uvawth 17 33 6 6 CD cord-266988-72uvawth 17 34 ] ] -RRB- cord-266988-72uvawth 17 35 . . . cord-266988-72uvawth 18 1 Additionally additionally RB cord-266988-72uvawth 18 2 , , , cord-266988-72uvawth 18 3 there there EX cord-266988-72uvawth 18 4 are be VBP cord-266988-72uvawth 18 5 also also RB cord-266988-72uvawth 18 6 published publish VBN cord-266988-72uvawth 18 7 reports report NNS cord-266988-72uvawth 18 8 on on IN cord-266988-72uvawth 18 9 the the DT cord-266988-72uvawth 18 10 pathogenesis pathogenesis NN cord-266988-72uvawth 18 11 of of IN cord-266988-72uvawth 18 12 other other JJ cord-266988-72uvawth 18 13 coronaviruses coronaviruse NNS cord-266988-72uvawth 18 14 such such JJ cord-266988-72uvawth 18 15 as as IN cord-266988-72uvawth 18 16 SARS SARS NNP cord-266988-72uvawth 18 17 - - HYPH cord-266988-72uvawth 18 18 CoV CoV NNP cord-266988-72uvawth 18 19 and and CC cord-266988-72uvawth 18 20 MERS MERS NNP cord-266988-72uvawth 18 21 - - HYPH cord-266988-72uvawth 18 22 CoV CoV NNP cord-266988-72uvawth 18 23 [ [ -LRB- cord-266988-72uvawth 18 24 7 7 CD cord-266988-72uvawth 18 25 ] ] -RRB- cord-266988-72uvawth 18 26 [ [ -LRB- cord-266988-72uvawth 18 27 8 8 CD cord-266988-72uvawth 18 28 ] ] -RRB- cord-266988-72uvawth 18 29 [ [ -LRB- cord-266988-72uvawth 18 30 9 9 CD cord-266988-72uvawth 18 31 ] ] -RRB- cord-266988-72uvawth 18 32 . . . cord-266988-72uvawth 19 1 In in IN cord-266988-72uvawth 19 2 early early JJ cord-266988-72uvawth 19 3 April April NNP cord-266988-72uvawth 19 4 a a DT cord-266988-72uvawth 19 5 Letter letter NN cord-266988-72uvawth 19 6 to to IN cord-266988-72uvawth 19 7 the the DT cord-266988-72uvawth 19 8 Editor Editor NNP cord-266988-72uvawth 19 9 appeared appear VBD cord-266988-72uvawth 19 10 online online RB cord-266988-72uvawth 19 11 in in IN cord-266988-72uvawth 19 12 Chest Chest NNP cord-266988-72uvawth 19 13 entitled entitle VBN cord-266988-72uvawth 19 14 " " `` cord-266988-72uvawth 19 15 A a DT cord-266988-72uvawth 19 16 call call NN cord-266988-72uvawth 19 17 to to IN cord-266988-72uvawth 19 18 action action NN cord-266988-72uvawth 19 19 : : : cord-266988-72uvawth 19 20 the the DT cord-266988-72uvawth 19 21 need need NN cord-266988-72uvawth 19 22 for for IN cord-266988-72uvawth 19 23 autopsies autopsy NNS cord-266988-72uvawth 19 24 to to TO cord-266988-72uvawth 19 25 determine determine VB cord-266988-72uvawth 19 26 the the DT cord-266988-72uvawth 19 27 full full JJ cord-266988-72uvawth 19 28 extent extent NN cord-266988-72uvawth 19 29 of of IN cord-266988-72uvawth 19 30 organ organ NN cord-266988-72uvawth 19 31 involvement involvement NN cord-266988-72uvawth 19 32 associated associate VBN cord-266988-72uvawth 19 33 with with IN cord-266988-72uvawth 19 34 COVID-19 COVID-19 NNP cord-266988-72uvawth 19 35 " " '' cord-266988-72uvawth 19 36 [ [ -LRB- cord-266988-72uvawth 19 37 10 10 CD cord-266988-72uvawth 19 38 ] ] -RRB- cord-266988-72uvawth 19 39 . . . cord-266988-72uvawth 20 1 This this DT cord-266988-72uvawth 20 2 was be VBD cord-266988-72uvawth 20 3 prompted prompt VBN cord-266988-72uvawth 20 4 by by IN cord-266988-72uvawth 20 5 the the DT cord-266988-72uvawth 20 6 stunning stunning JJ cord-266988-72uvawth 20 7 lack lack NN cord-266988-72uvawth 20 8 of of IN cord-266988-72uvawth 20 9 publications publication NNS cord-266988-72uvawth 20 10 relating relate VBG cord-266988-72uvawth 20 11 to to IN cord-266988-72uvawth 20 12 autopsy autopsy JJ cord-266988-72uvawth 20 13 findings finding NNS cord-266988-72uvawth 20 14 in in IN cord-266988-72uvawth 20 15 decedents decedent NNS cord-266988-72uvawth 20 16 who who WP cord-266988-72uvawth 20 17 had have VBD cord-266988-72uvawth 20 18 succumbed succumb VBN cord-266988-72uvawth 20 19 to to IN cord-266988-72uvawth 20 20 COVID-19 covid-19 VB cord-266988-72uvawth 20 21 infections infection NNS cord-266988-72uvawth 20 22 despite despite IN cord-266988-72uvawth 20 23 the the DT cord-266988-72uvawth 20 24 fact fact NN cord-266988-72uvawth 20 25 that that IN cord-266988-72uvawth 20 26 several several JJ cord-266988-72uvawth 20 27 hundred hundred CD cord-266988-72uvawth 20 28 thousand thousand CD cord-266988-72uvawth 20 29 individuals individual NNS cord-266988-72uvawth 20 30 already already RB cord-266988-72uvawth 20 31 had have VBD cord-266988-72uvawth 20 32 died die VBN cord-266988-72uvawth 20 33 by by IN cord-266988-72uvawth 20 34 that that DT cord-266988-72uvawth 20 35 time time NN cord-266988-72uvawth 20 36 [ [ -LRB- cord-266988-72uvawth 20 37 11 11 CD cord-266988-72uvawth 20 38 ] ] -RRB- cord-266988-72uvawth 20 39 . . . cord-266988-72uvawth 21 1 Since since IN cord-266988-72uvawth 21 2 then then RB cord-266988-72uvawth 21 3 , , , cord-266988-72uvawth 21 4 at at IN cord-266988-72uvawth 21 5 the the DT cord-266988-72uvawth 21 6 time time NN cord-266988-72uvawth 21 7 of of IN cord-266988-72uvawth 21 8 this this DT cord-266988-72uvawth 21 9 writing writing NN cord-266988-72uvawth 21 10 in in IN cord-266988-72uvawth 21 11 late late JJ cord-266988-72uvawth 21 12 June June NNP cord-266988-72uvawth 21 13 and and CC cord-266988-72uvawth 21 14 to to IN cord-266988-72uvawth 21 15 the the DT cord-266988-72uvawth 21 16 best good JJS cord-266988-72uvawth 21 17 of of IN cord-266988-72uvawth 21 18 our -PRON- PRP$ cord-266988-72uvawth 21 19 knowledge knowledge NN cord-266988-72uvawth 21 20 , , , cord-266988-72uvawth 21 21 there there EX cord-266988-72uvawth 21 22 have have VBP cord-266988-72uvawth 21 23 been be VBN cord-266988-72uvawth 21 24 at at RB cord-266988-72uvawth 21 25 least least RBS cord-266988-72uvawth 21 26 13 13 CD cord-266988-72uvawth 21 27 reports report NNS cord-266988-72uvawth 21 28 describing describe VBG cord-266988-72uvawth 21 29 autopsy autopsy JJ cord-266988-72uvawth 21 30 findings finding NNS cord-266988-72uvawth 21 31 in in IN cord-266988-72uvawth 21 32 approximately approximately RB cord-266988-72uvawth 21 33 250 250 CD cord-266988-72uvawth 21 34 decedents decedent NNS cord-266988-72uvawth 21 35 who who WP cord-266988-72uvawth 21 36 have have VBP cord-266988-72uvawth 21 37 succumbed succumb VBN cord-266988-72uvawth 21 38 to to TO cord-266988-72uvawth 21 39 COVID-19 covid-19 VB cord-266988-72uvawth 21 40 [ [ -LRB- cord-266988-72uvawth 21 41 4 4 CD cord-266988-72uvawth 21 42 , , , cord-266988-72uvawth 21 43 [ [ -LRB- cord-266988-72uvawth 21 44 12 12 CD cord-266988-72uvawth 21 45 ] ] -RRB- cord-266988-72uvawth 21 46 [ [ -LRB- cord-266988-72uvawth 21 47 13 13 CD cord-266988-72uvawth 21 48 ] ] -RRB- cord-266988-72uvawth 22 1 [ [ -LRB- cord-266988-72uvawth 22 2 14 14 CD cord-266988-72uvawth 22 3 ] ] -RRB- cord-266988-72uvawth 23 1 [ [ -LRB- cord-266988-72uvawth 23 2 15 15 CD cord-266988-72uvawth 23 3 ] ] -RRB- cord-266988-72uvawth 23 4 [ [ -LRB- cord-266988-72uvawth 23 5 16 16 CD cord-266988-72uvawth 23 6 ] ] -RRB- cord-266988-72uvawth 23 7 [ [ -LRB- cord-266988-72uvawth 23 8 17 17 CD cord-266988-72uvawth 23 9 ] ] -RRB- cord-266988-72uvawth 23 10 [ [ -LRB- cord-266988-72uvawth 23 11 18 18 CD cord-266988-72uvawth 23 12 ] ] -RRB- cord-266988-72uvawth 23 13 [ [ -LRB- cord-266988-72uvawth 23 14 19 19 CD cord-266988-72uvawth 23 15 ] ] -RRB- cord-266988-72uvawth 24 1 [ [ -LRB- cord-266988-72uvawth 24 2 20 20 CD cord-266988-72uvawth 24 3 ] ] -RRB- cord-266988-72uvawth 24 4 [ [ -LRB- cord-266988-72uvawth 24 5 21 21 CD cord-266988-72uvawth 24 6 ] ] -RRB- cord-266988-72uvawth 25 1 [ [ -LRB- cord-266988-72uvawth 25 2 22 22 CD cord-266988-72uvawth 25 3 ] ] -RRB- cord-266988-72uvawth 26 1 In in IN cord-266988-72uvawth 26 2 the the DT cord-266988-72uvawth 26 3 meantime meantime NN cord-266988-72uvawth 26 4 , , , cord-266988-72uvawth 26 5 as as IN cord-266988-72uvawth 26 6 of of IN cord-266988-72uvawth 26 7 June June NNP cord-266988-72uvawth 26 8 15 15 CD cord-266988-72uvawth 26 9 , , , cord-266988-72uvawth 26 10 2020 2020 CD cord-266988-72uvawth 26 11 , , , cord-266988-72uvawth 26 12 the the DT cord-266988-72uvawth 26 13 number number NN cord-266988-72uvawth 26 14 of of IN cord-266988-72uvawth 26 15 confirmed confirm VBN cord-266988-72uvawth 26 16 cases case NNS cord-266988-72uvawth 26 17 has have VBZ cord-266988-72uvawth 26 18 climbed climb VBN cord-266988-72uvawth 26 19 to to IN cord-266988-72uvawth 26 20 over over IN cord-266988-72uvawth 26 21 2.1 2.1 CD cord-266988-72uvawth 26 22 million million CD cord-266988-72uvawth 26 23 and and CC cord-266988-72uvawth 26 24 over over IN cord-266988-72uvawth 26 25 115,000 115,000 CD cord-266988-72uvawth 26 26 deaths death NNS cord-266988-72uvawth 26 27 in in IN cord-266988-72uvawth 26 28 the the DT cord-266988-72uvawth 26 29 United United NNP cord-266988-72uvawth 26 30 States States NNP cord-266988-72uvawth 26 31 and and CC cord-266988-72uvawth 26 32 8 8 CD cord-266988-72uvawth 26 33 million million CD cord-266988-72uvawth 26 34 cases case NNS cord-266988-72uvawth 26 35 and and CC cord-266988-72uvawth 26 36 more more JJR cord-266988-72uvawth 26 37 than than IN cord-266988-72uvawth 26 38 440,000 440,000 CD cord-266988-72uvawth 26 39 deaths death NNS cord-266988-72uvawth 26 40 worldwide worldwide RB cord-266988-72uvawth 26 41 . . . cord-266988-72uvawth 27 1 Therefore therefore RB cord-266988-72uvawth 27 2 , , , cord-266988-72uvawth 27 3 the the DT cord-266988-72uvawth 27 4 total total JJ cord-266988-72uvawth 27 5 number number NN cord-266988-72uvawth 27 6 of of IN cord-266988-72uvawth 27 7 autopsies autopsy NNS cord-266988-72uvawth 27 8 performed perform VBN cord-266988-72uvawth 27 9 is be VBZ cord-266988-72uvawth 27 10 miniscule miniscule JJ cord-266988-72uvawth 27 11 compared compare VBN cord-266988-72uvawth 27 12 to to IN cord-266988-72uvawth 27 13 the the DT cord-266988-72uvawth 27 14 number number NN cord-266988-72uvawth 27 15 of of IN cord-266988-72uvawth 27 16 deaths death NNS cord-266988-72uvawth 27 17 , , , cord-266988-72uvawth 27 18 but but CC cord-266988-72uvawth 27 19 nevertheless nevertheless RB cord-266988-72uvawth 27 20 they -PRON- PRP cord-266988-72uvawth 27 21 are be VBP cord-266988-72uvawth 27 22 both both DT cord-266988-72uvawth 27 23 very very RB cord-266988-72uvawth 27 24 revealing revealing JJ cord-266988-72uvawth 27 25 and and CC cord-266988-72uvawth 27 26 important important JJ cord-266988-72uvawth 27 27 in in IN cord-266988-72uvawth 27 28 order order NN cord-266988-72uvawth 27 29 to to TO cord-266988-72uvawth 27 30 better better RB cord-266988-72uvawth 27 31 understand understand VB cord-266988-72uvawth 27 32 the the DT cord-266988-72uvawth 27 33 multi multi JJ cord-266988-72uvawth 27 34 - - JJ cord-266988-72uvawth 27 35 organ organ JJ cord-266988-72uvawth 27 36 involvement involvement NN cord-266988-72uvawth 27 37 associated associate VBN cord-266988-72uvawth 27 38 with with IN cord-266988-72uvawth 27 39 COVID-19 covid-19 JJ cord-266988-72uvawth 27 40 infection infection NN cord-266988-72uvawth 27 41 and and CC cord-266988-72uvawth 27 42 for for IN cord-266988-72uvawth 27 43 the the DT cord-266988-72uvawth 27 44 development development NN cord-266988-72uvawth 27 45 of of IN cord-266988-72uvawth 27 46 better well JJR cord-266988-72uvawth 27 47 treatment treatment NN cord-266988-72uvawth 27 48 strategies strategy NNS cord-266988-72uvawth 27 49 [ [ -LRB- cord-266988-72uvawth 27 50 1 1 CD cord-266988-72uvawth 27 51 , , , cord-266988-72uvawth 27 52 3 3 CD cord-266988-72uvawth 27 53 ] ] -RRB- cord-266988-72uvawth 27 54 . . . cord-266988-72uvawth 28 1 The the DT cord-266988-72uvawth 28 2 three three CD cord-266988-72uvawth 28 3 largest large JJS cord-266988-72uvawth 28 4 and and CC cord-266988-72uvawth 28 5 most most RBS cord-266988-72uvawth 28 6 recent recent JJ cord-266988-72uvawth 28 7 of of IN cord-266988-72uvawth 28 8 these these DT cord-266988-72uvawth 28 9 are be VBP cord-266988-72uvawth 28 10 reports report NNS cord-266988-72uvawth 28 11 from from IN cord-266988-72uvawth 28 12 the the DT cord-266988-72uvawth 28 13 Mount Mount NNP cord-266988-72uvawth 28 14 Sinai Sinai NNP cord-266988-72uvawth 28 15 Hospital Hospital NNP cord-266988-72uvawth 28 16 in in IN cord-266988-72uvawth 28 17 New New NNP cord-266988-72uvawth 28 18 York York NNP cord-266988-72uvawth 28 19 City City NNP cord-266988-72uvawth 28 20 of of IN cord-266988-72uvawth 28 21 67 67 CD cord-266988-72uvawth 28 22 decedents decedent NNS cord-266988-72uvawth 28 23 [ [ -LRB- cord-266988-72uvawth 28 24 12 12 CD cord-266988-72uvawth 28 25 ] ] -RRB- cord-266988-72uvawth 28 26 , , , cord-266988-72uvawth 28 27 the the DT cord-266988-72uvawth 28 28 L. L. NNP cord-266988-72uvawth 28 29 Sacco Sacco NNP cord-266988-72uvawth 28 30 Hospital Hospital NNP cord-266988-72uvawth 28 31 in in IN cord-266988-72uvawth 28 32 Milan Milan NNP cord-266988-72uvawth 28 33 , , , cord-266988-72uvawth 28 34 Italy Italy NNP cord-266988-72uvawth 28 35 of of IN cord-266988-72uvawth 28 36 38 38 CD cord-266988-72uvawth 28 37 , , , cord-266988-72uvawth 28 38 limited limit VBN cord-266988-72uvawth 28 39 to to IN cord-266988-72uvawth 28 40 the the DT cord-266988-72uvawth 28 41 lungs lung NNS cord-266988-72uvawth 28 42 [ [ -LRB- cord-266988-72uvawth 28 43 14 14 CD cord-266988-72uvawth 28 44 ] ] -RRB- cord-266988-72uvawth 28 45 and and CC cord-266988-72uvawth 28 46 the the DT cord-266988-72uvawth 28 47 University University NNP cord-266988-72uvawth 28 48 Hospital Hospital NNP cord-266988-72uvawth 28 49 in in IN cord-266988-72uvawth 28 50 Basel Basel NNP cord-266988-72uvawth 28 51 Switzerland Switzerland NNP cord-266988-72uvawth 28 52 of of IN cord-266988-72uvawth 28 53 21 21 CD cord-266988-72uvawth 28 54 decedents decedent NNS cord-266988-72uvawth 28 55 [ [ -LRB- cord-266988-72uvawth 28 56 19 19 CD cord-266988-72uvawth 28 57 ] ] -RRB- cord-266988-72uvawth 28 58 . . . cord-266988-72uvawth 29 1 These these DT cord-266988-72uvawth 29 2 three three CD cord-266988-72uvawth 29 3 reports report NNS cord-266988-72uvawth 29 4 taken take VBN cord-266988-72uvawth 29 5 together together RB cord-266988-72uvawth 29 6 have have VBP cord-266988-72uvawth 29 7 provided provide VBN cord-266988-72uvawth 29 8 a a DT cord-266988-72uvawth 29 9 more more RBR cord-266988-72uvawth 29 10 complete complete JJ cord-266988-72uvawth 29 11 picture picture NN cord-266988-72uvawth 29 12 of of IN cord-266988-72uvawth 29 13 the the DT cord-266988-72uvawth 29 14 various various JJ cord-266988-72uvawth 29 15 organs organ NNS cord-266988-72uvawth 29 16 that that WDT cord-266988-72uvawth 29 17 can can MD cord-266988-72uvawth 29 18 be be VB cord-266988-72uvawth 29 19 involved involve VBN cord-266988-72uvawth 29 20 in in IN cord-266988-72uvawth 29 21 individuals individual NNS cord-266988-72uvawth 29 22 who who WP cord-266988-72uvawth 29 23 succumb succumb VBP cord-266988-72uvawth 29 24 to to TO cord-266988-72uvawth 29 25 COVID-19 covid-19 VB cord-266988-72uvawth 29 26 . . . cord-266988-72uvawth 30 1 What what WP cord-266988-72uvawth 30 2 initially initially RB cord-266988-72uvawth 30 3 was be VBD cord-266988-72uvawth 30 4 thought think VBN cord-266988-72uvawth 30 5 to to TO cord-266988-72uvawth 30 6 be be VB cord-266988-72uvawth 30 7 a a DT cord-266988-72uvawth 30 8 disease disease NN cord-266988-72uvawth 30 9 almost almost RB cord-266988-72uvawth 30 10 exclusively exclusively RB cord-266988-72uvawth 30 11 involving involve VBG cord-266988-72uvawth 30 12 the the DT cord-266988-72uvawth 30 13 lungs lung NNS cord-266988-72uvawth 30 14 now now RB cord-266988-72uvawth 30 15 is be VBZ cord-266988-72uvawth 30 16 being be VBG cord-266988-72uvawth 30 17 recognized recognize VBN cord-266988-72uvawth 30 18 as as IN cord-266988-72uvawth 30 19 one one CD cord-266988-72uvawth 30 20 that that WDT cord-266988-72uvawth 30 21 involves involve VBZ cord-266988-72uvawth 30 22 multiple multiple JJ cord-266988-72uvawth 30 23 organ organ NN cord-266988-72uvawth 30 24 systems system NNS cord-266988-72uvawth 30 25 including include VBG cord-266988-72uvawth 30 26 the the DT cord-266988-72uvawth 30 27 heart heart NN cord-266988-72uvawth 30 28 , , , cord-266988-72uvawth 30 29 kidneys kidney NNS cord-266988-72uvawth 30 30 , , , cord-266988-72uvawth 30 31 bone bone NN cord-266988-72uvawth 30 32 marrow marrow NN cord-266988-72uvawth 30 33 , , , cord-266988-72uvawth 30 34 lymph lymph NN cord-266988-72uvawth 30 35 nodes node NNS cord-266988-72uvawth 30 36 and and CC cord-266988-72uvawth 30 37 brain brain NN cord-266988-72uvawth 30 38 . . . cord-266988-72uvawth 31 1 The the DT cord-266988-72uvawth 31 2 underlying underlie VBG cord-266988-72uvawth 31 3 pathology pathology NN cord-266988-72uvawth 31 4 of of IN cord-266988-72uvawth 31 5 COVID-19 covid-19 JJ cord-266988-72uvawth 31 6 infection infection NN cord-266988-72uvawth 31 7 appears appear VBZ cord-266988-72uvawth 31 8 to to TO cord-266988-72uvawth 31 9 be be VB cord-266988-72uvawth 31 10 involvement involvement NN cord-266988-72uvawth 31 11 of of IN cord-266988-72uvawth 31 12 vascular vascular JJ cord-266988-72uvawth 31 13 endothelium endothelium NN cord-266988-72uvawth 31 14 of of IN cord-266988-72uvawth 31 15 multiple multiple JJ cord-266988-72uvawth 31 16 organs organ NNS cord-266988-72uvawth 31 17 [ [ -LRB- cord-266988-72uvawth 31 18 4 4 CD cord-266988-72uvawth 31 19 ] ] -RRB- cord-266988-72uvawth 31 20 . . . cord-266988-72uvawth 32 1 It -PRON- PRP cord-266988-72uvawth 32 2 is be VBZ cord-266988-72uvawth 32 3 noteworthy noteworthy JJ cord-266988-72uvawth 32 4 that that IN cord-266988-72uvawth 32 5 in in IN cord-266988-72uvawth 32 6 the the DT cord-266988-72uvawth 32 7 Chinese chinese JJ cord-266988-72uvawth 32 8 medical medical JJ cord-266988-72uvawth 32 9 literature literature NN cord-266988-72uvawth 32 10 there there EX cord-266988-72uvawth 32 11 was be VBD cord-266988-72uvawth 32 12 , , , cord-266988-72uvawth 32 13 as as IN cord-266988-72uvawth 32 14 of of IN cord-266988-72uvawth 32 15 March March NNP cord-266988-72uvawth 32 16 2020 2020 CD cord-266988-72uvawth 32 17 , , , cord-266988-72uvawth 32 18 only only RB cord-266988-72uvawth 32 19 one one CD cord-266988-72uvawth 32 20 autopsy autopsy JJ cord-266988-72uvawth 32 21 report report NN cord-266988-72uvawth 32 22 of of IN cord-266988-72uvawth 32 23 a a DT cord-266988-72uvawth 32 24 decedent decedent NN cord-266988-72uvawth 32 25 who who WP cord-266988-72uvawth 32 26 had have VBD cord-266988-72uvawth 32 27 succumbed succumb VBN cord-266988-72uvawth 32 28 to to IN cord-266988-72uvawth 32 29 COVID-19 covid-19 VB cord-266988-72uvawth 32 30 and and CC cord-266988-72uvawth 32 31 this this DT cord-266988-72uvawth 32 32 was be VBD cord-266988-72uvawth 32 33 published publish VBN cord-266988-72uvawth 32 34 in in IN cord-266988-72uvawth 32 35 Chinese Chinese NNP cord-266988-72uvawth 32 36 in in IN cord-266988-72uvawth 32 37 the the DT cord-266988-72uvawth 32 38 Journal Journal NNP cord-266988-72uvawth 32 39 of of IN cord-266988-72uvawth 32 40 Forensic Forensic NNP cord-266988-72uvawth 32 41 Medicine Medicine NNP cord-266988-72uvawth 32 42 [ [ -LRB- cord-266988-72uvawth 32 43 23 23 CD cord-266988-72uvawth 32 44 ] ] -RRB- cord-266988-72uvawth 32 45 . . . cord-266988-72uvawth 33 1 Unfortunately unfortunately RB cord-266988-72uvawth 33 2 , , , cord-266988-72uvawth 33 3 no no DT cord-266988-72uvawth 33 4 diagnoses diagnosis NNS cord-266988-72uvawth 33 5 were be VBD cord-266988-72uvawth 33 6 given give VBN cord-266988-72uvawth 33 7 nor nor CC cord-266988-72uvawth 33 8 was be VBD cord-266988-72uvawth 33 9 microscopic microscopic JJ cord-266988-72uvawth 33 10 examination examination NN cord-266988-72uvawth 33 11 carried carry VBN cord-266988-72uvawth 33 12 out out RP cord-266988-72uvawth 33 13 making make VBG cord-266988-72uvawth 33 14 this this DT cord-266988-72uvawth 33 15 report report NN cord-266988-72uvawth 33 16 of of IN cord-266988-72uvawth 33 17 very very RB cord-266988-72uvawth 33 18 limited limited JJ cord-266988-72uvawth 33 19 usefulness usefulness NN cord-266988-72uvawth 33 20 . . . cord-266988-72uvawth 34 1 This this DT cord-266988-72uvawth 34 2 in in IN cord-266988-72uvawth 34 3 part part NN cord-266988-72uvawth 34 4 is be VBZ cord-266988-72uvawth 34 5 due due JJ cord-266988-72uvawth 34 6 to to IN cord-266988-72uvawth 34 7 the the DT cord-266988-72uvawth 34 8 fact fact NN cord-266988-72uvawth 34 9 that that IN cord-266988-72uvawth 34 10 very very RB cord-266988-72uvawth 34 11 few few JJ cord-266988-72uvawth 34 12 autopsies autopsy NNS cord-266988-72uvawth 34 13 are be VBP cord-266988-72uvawth 34 14 carried carry VBN cord-266988-72uvawth 34 15 out out RP cord-266988-72uvawth 34 16 in in IN cord-266988-72uvawth 34 17 China China NNP cord-266988-72uvawth 34 18 and and CC cord-266988-72uvawth 34 19 most most JJS cord-266988-72uvawth 34 20 of of IN cord-266988-72uvawth 34 21 these these DT cord-266988-72uvawth 34 22 seem seem VBP cord-266988-72uvawth 34 23 to to TO cord-266988-72uvawth 34 24 be be VB cord-266988-72uvawth 34 25 forensic forensic JJ cord-266988-72uvawth 34 26 autopsies autopsy NNS cord-266988-72uvawth 34 27 . . . cord-266988-72uvawth 35 1 Several several JJ cord-266988-72uvawth 35 2 other other JJ cord-266988-72uvawth 35 3 reports report NNS cord-266988-72uvawth 35 4 from from IN cord-266988-72uvawth 35 5 China China NNP cord-266988-72uvawth 35 6 have have VBP cord-266988-72uvawth 35 7 provided provide VBN cord-266988-72uvawth 35 8 some some DT cord-266988-72uvawth 35 9 detailed detailed JJ cord-266988-72uvawth 35 10 histopathologic histopathologic JJ cord-266988-72uvawth 35 11 information information NN cord-266988-72uvawth 35 12 based base VBN cord-266988-72uvawth 35 13 on on IN cord-266988-72uvawth 35 14 " " `` cord-266988-72uvawth 35 15 biopsies biopsy NNS cord-266988-72uvawth 35 16 " " '' cord-266988-72uvawth 35 17 of of IN cord-266988-72uvawth 35 18 the the DT cord-266988-72uvawth 35 19 lungs lung NNS cord-266988-72uvawth 35 20 and and CC cord-266988-72uvawth 35 21 kidneys kidney NNS cord-266988-72uvawth 35 22 of of IN cord-266988-72uvawth 35 23 a a DT cord-266988-72uvawth 35 24 few few JJ cord-266988-72uvawth 35 25 decedents decedent NNS cord-266988-72uvawth 35 26 taken take VBN cord-266988-72uvawth 35 27 following follow VBG cord-266988-72uvawth 35 28 their -PRON- PRP$ cord-266988-72uvawth 35 29 death death NN cord-266988-72uvawth 35 30 [ [ -LRB- cord-266988-72uvawth 35 31 8 8 CD cord-266988-72uvawth 35 32 , , , cord-266988-72uvawth 35 33 24 24 CD cord-266988-72uvawth 35 34 , , , cord-266988-72uvawth 35 35 25 25 CD cord-266988-72uvawth 35 36 ] ] -RRB- cord-266988-72uvawth 35 37 . . . cord-266988-72uvawth 36 1 Even even RB cord-266988-72uvawth 36 2 with with IN cord-266988-72uvawth 36 3 this this DT cord-266988-72uvawth 36 4 limitation limitation NN cord-266988-72uvawth 36 5 , , , cord-266988-72uvawth 36 6 very very RB cord-266988-72uvawth 36 7 important important JJ cord-266988-72uvawth 36 8 information information NN cord-266988-72uvawth 36 9 was be VBD cord-266988-72uvawth 36 10 obtained obtain VBN cord-266988-72uvawth 36 11 , , , cord-266988-72uvawth 36 12 which which WDT cord-266988-72uvawth 36 13 described describe VBD cord-266988-72uvawth 36 14 the the DT cord-266988-72uvawth 36 15 major major JJ cord-266988-72uvawth 36 16 hallmark hallmark NN cord-266988-72uvawth 36 17 of of IN cord-266988-72uvawth 36 18 COVID-19 COVID-19 NNP cord-266988-72uvawth 36 19 infection infection NN cord-266988-72uvawth 36 20 , , , cord-266988-72uvawth 36 21 namely namely RB cord-266988-72uvawth 36 22 diffuse diffuse VB cord-266988-72uvawth 36 23 alveolar alveolar NN cord-266988-72uvawth 36 24 damage damage NN cord-266988-72uvawth 36 25 ( ( -LRB- cord-266988-72uvawth 36 26 DAD DAD NNP cord-266988-72uvawth 36 27 ) ) -RRB- cord-266988-72uvawth 36 28 of of IN cord-266988-72uvawth 36 29 the the DT cord-266988-72uvawth 36 30 lungs lung NNS cord-266988-72uvawth 36 31 and and CC cord-266988-72uvawth 36 32 a a DT cord-266988-72uvawth 36 33 glomerulopathy glomerulopathy NN cord-266988-72uvawth 36 34 involving involve VBG cord-266988-72uvawth 36 35 the the DT cord-266988-72uvawth 36 36 kidneys kidney NNS cord-266988-72uvawth 36 37 . . . cord-266988-72uvawth 37 1 Although although IN cord-266988-72uvawth 37 2 autopsies autopsy NNS cord-266988-72uvawth 37 3 have have VBP cord-266988-72uvawth 37 4 shown show VBN cord-266988-72uvawth 37 5 a a DT cord-266988-72uvawth 37 6 steep steep JJ cord-266988-72uvawth 37 7 decline decline NN cord-266988-72uvawth 37 8 in in IN cord-266988-72uvawth 37 9 almost almost RB cord-266988-72uvawth 37 10 all all DT cord-266988-72uvawth 37 11 countries country NNS cord-266988-72uvawth 37 12 of of IN cord-266988-72uvawth 37 13 the the DT cord-266988-72uvawth 37 14 world world NN cord-266988-72uvawth 37 15 , , , cord-266988-72uvawth 37 16 they -PRON- PRP cord-266988-72uvawth 37 17 still still RB cord-266988-72uvawth 37 18 remain remain VBP cord-266988-72uvawth 37 19 a a DT cord-266988-72uvawth 37 20 very very RB cord-266988-72uvawth 37 21 powerful powerful JJ cord-266988-72uvawth 37 22 tool tool NN cord-266988-72uvawth 37 23 [ [ -LRB- cord-266988-72uvawth 37 24 26 26 CD cord-266988-72uvawth 37 25 ] ] -RRB- cord-266988-72uvawth 37 26 to to TO cord-266988-72uvawth 37 27 develop develop VB cord-266988-72uvawth 37 28 a a DT cord-266988-72uvawth 37 29 full full JJ cord-266988-72uvawth 37 30 understanding understanding NN cord-266988-72uvawth 37 31 of of IN cord-266988-72uvawth 37 32 a a DT cord-266988-72uvawth 37 33 new new JJ cord-266988-72uvawth 37 34 and and CC cord-266988-72uvawth 37 35 previously previously RB cord-266988-72uvawth 37 36 unknown unknown JJ cord-266988-72uvawth 37 37 diseases disease NNS cord-266988-72uvawth 37 38 such such JJ cord-266988-72uvawth 37 39 as as IN cord-266988-72uvawth 37 40 SARS SARS NNP cord-266988-72uvawth 37 41 - - HYPH cord-266988-72uvawth 37 42 CoV2 CoV2 NNP cord-266988-72uvawth 37 43 . . . cord-266988-72uvawth 38 1 It -PRON- PRP cord-266988-72uvawth 38 2 is be VBZ cord-266988-72uvawth 38 3 beyond beyond IN cord-266988-72uvawth 38 4 the the DT cord-266988-72uvawth 38 5 scope scope NN cord-266988-72uvawth 38 6 of of IN cord-266988-72uvawth 38 7 this this DT cord-266988-72uvawth 38 8 Editorial Editorial NNP cord-266988-72uvawth 38 9 to to TO cord-266988-72uvawth 38 10 go go VB cord-266988-72uvawth 38 11 into into IN cord-266988-72uvawth 38 12 a a DT cord-266988-72uvawth 38 13 detailed detailed JJ cord-266988-72uvawth 38 14 discussion discussion NN cord-266988-72uvawth 38 15 of of IN cord-266988-72uvawth 38 16 the the DT cord-266988-72uvawth 38 17 specific specific JJ cord-266988-72uvawth 38 18 pathologies pathology NNS cord-266988-72uvawth 38 19 associated associate VBN cord-266988-72uvawth 38 20 with with IN cord-266988-72uvawth 38 21 COVID-19 covid-19 JJ cord-266988-72uvawth 38 22 infection infection NN cord-266988-72uvawth 38 23 , , , cord-266988-72uvawth 38 24 but but CC cord-266988-72uvawth 38 25 , , , cord-266988-72uvawth 38 26 based base VBN cord-266988-72uvawth 38 27 on on IN cord-266988-72uvawth 38 28 the the DT cord-266988-72uvawth 38 29 autopsy autopsy JJ cord-266988-72uvawth 38 30 reports report NNS cord-266988-72uvawth 38 31 to to IN cord-266988-72uvawth 38 32 date date NN cord-266988-72uvawth 38 33 , , , cord-266988-72uvawth 38 34 a a DT cord-266988-72uvawth 38 35 much much RB cord-266988-72uvawth 38 36 clearer clear JJR cord-266988-72uvawth 38 37 picture picture NN cord-266988-72uvawth 38 38 is be VBZ cord-266988-72uvawth 38 39 emerging emerge VBG cord-266988-72uvawth 38 40 and and CC cord-266988-72uvawth 38 41 will will MD cord-266988-72uvawth 38 42 be be VB cord-266988-72uvawth 38 43 briefly briefly RB cord-266988-72uvawth 38 44 summarized summarize VBN cord-266988-72uvawth 38 45 here here RB cord-266988-72uvawth 38 46 . . . cord-266988-72uvawth 39 1 Readers reader NNS cord-266988-72uvawth 39 2 interested interested JJ cord-266988-72uvawth 39 3 in in IN cord-266988-72uvawth 39 4 more more RBR cord-266988-72uvawth 39 5 detailed detailed JJ cord-266988-72uvawth 39 6 information information NN cord-266988-72uvawth 39 7 are be VBP cord-266988-72uvawth 39 8 referred refer VBN cord-266988-72uvawth 39 9 to to IN cord-266988-72uvawth 39 10 the the DT cord-266988-72uvawth 39 11 report report NN cord-266988-72uvawth 39 12 cited cite VBN cord-266988-72uvawth 39 13 in in IN cord-266988-72uvawth 39 14 the the DT cord-266988-72uvawth 39 15 references reference NNS cord-266988-72uvawth 39 16 in in IN cord-266988-72uvawth 39 17 this this DT cord-266988-72uvawth 39 18 editorial editorial NN cord-266988-72uvawth 39 19 . . . cord-266988-72uvawth 40 1 For for IN cord-266988-72uvawth 40 2 a a DT cord-266988-72uvawth 40 3 more more RBR cord-266988-72uvawth 40 4 comprehensive comprehensive JJ cord-266988-72uvawth 40 5 overview overview NN cord-266988-72uvawth 40 6 of of IN cord-266988-72uvawth 40 7 SARS SARS NNP cord-266988-72uvawth 40 8 - - HYPH cord-266988-72uvawth 40 9 CoV2 CoV2 NNP cord-266988-72uvawth 40 10 and and CC cord-266988-72uvawth 40 11 COVID-19 COVID-19 NNP cord-266988-72uvawth 40 12 disease disease NN cord-266988-72uvawth 40 13 readers reader NNS cord-266988-72uvawth 40 14 are be VBP cord-266988-72uvawth 40 15 referred refer VBN cord-266988-72uvawth 40 16 to to IN cord-266988-72uvawth 40 17 a a DT cord-266988-72uvawth 40 18 soon soon RB cord-266988-72uvawth 40 19 to to TO cord-266988-72uvawth 40 20 be be VB cord-266988-72uvawth 40 21 published publish VBN cord-266988-72uvawth 40 22 review review NN cord-266988-72uvawth 40 23 by by IN cord-266988-72uvawth 40 24 Mohanty Mohanty NNP cord-266988-72uvawth 40 25 et et NNP cord-266988-72uvawth 40 26 al al NNP cord-266988-72uvawth 40 27 . . . cord-266988-72uvawth 41 1 , , , cord-266988-72uvawth 41 2 2020 2020 CD cord-266988-72uvawth 41 3 [ [ -LRB- cord-266988-72uvawth 41 4 27 27 CD cord-266988-72uvawth 41 5 ] ] -RRB- cord-266988-72uvawth 41 6 . . . cord-266988-72uvawth 42 1 Acute acute JJ cord-266988-72uvawth 42 2 severe severe JJ cord-266988-72uvawth 42 3 COVID-19 covid-19 JJ cord-266988-72uvawth 42 4 respiratory respiratory JJ cord-266988-72uvawth 42 5 disease disease NN cord-266988-72uvawth 42 6 develops develop VBZ cord-266988-72uvawth 42 7 as as IN cord-266988-72uvawth 42 8 a a DT cord-266988-72uvawth 42 9 severe severe JJ cord-266988-72uvawth 42 10 acute acute JJ cord-266988-72uvawth 42 11 respiratory respiratory JJ cord-266988-72uvawth 42 12 distress distress NN cord-266988-72uvawth 42 13 syndrome syndrome NN cord-266988-72uvawth 42 14 ( ( -LRB- cord-266988-72uvawth 42 15 ARDS ARDS NNP cord-266988-72uvawth 42 16 ) ) -RRB- cord-266988-72uvawth 42 17 that that IN cord-266988-72uvawth 42 18 autopsy autopsy JJ cord-266988-72uvawth 42 19 studies study NNS cord-266988-72uvawth 42 20 have have VBP cord-266988-72uvawth 42 21 shown show VBN cord-266988-72uvawth 42 22 to to TO cord-266988-72uvawth 42 23 be be VB cord-266988-72uvawth 42 24 related relate VBN cord-266988-72uvawth 42 25 to to IN cord-266988-72uvawth 42 26 an an DT cord-266988-72uvawth 42 27 underlying underlying JJ cord-266988-72uvawth 42 28 severe severe JJ cord-266988-72uvawth 42 29 form form NN cord-266988-72uvawth 42 30 of of IN cord-266988-72uvawth 42 31 DAD DAD NNP cord-266988-72uvawth 42 32 in in IN cord-266988-72uvawth 42 33 the the DT cord-266988-72uvawth 42 34 acute acute JJ cord-266988-72uvawth 42 35 , , , cord-266988-72uvawth 42 36 exudative exudative JJ cord-266988-72uvawth 42 37 phase phase NN cord-266988-72uvawth 42 38 . . . cord-266988-72uvawth 43 1 COVID-19-induced COVID-19-induced NNP cord-266988-72uvawth 44 1 DAD DAD NNP cord-266988-72uvawth 44 2 is be VBZ cord-266988-72uvawth 44 3 characterized characterize VBN cord-266988-72uvawth 44 4 by by IN cord-266988-72uvawth 44 5 damage damage NN cord-266988-72uvawth 44 6 to to IN cord-266988-72uvawth 44 7 alveolar alveolar NN cord-266988-72uvawth 44 8 capillary capillary JJ cord-266988-72uvawth 44 9 endothelium endothelium NN cord-266988-72uvawth 44 10 and and CC cord-266988-72uvawth 44 11 type type NN cord-266988-72uvawth 44 12 II ii NN cord-266988-72uvawth 44 13 pneumocytes pneumocyte NNS cord-266988-72uvawth 44 14 leading lead VBG cord-266988-72uvawth 44 15 to to IN cord-266988-72uvawth 44 16 alveolar alveolar JJ cord-266988-72uvawth 44 17 septal septal JJ cord-266988-72uvawth 44 18 edema edema NN cord-266988-72uvawth 44 19 and and CC cord-266988-72uvawth 44 20 the the DT cord-266988-72uvawth 44 21 formation formation NN cord-266988-72uvawth 44 22 of of IN cord-266988-72uvawth 44 23 hyaline hyaline JJ cord-266988-72uvawth 44 24 membranes membrane NNS cord-266988-72uvawth 44 25 , , , cord-266988-72uvawth 44 26 accumulation accumulation NN cord-266988-72uvawth 44 27 of of IN cord-266988-72uvawth 44 28 numerous numerous JJ cord-266988-72uvawth 44 29 megakaryocytes megakaryocyte NNS cord-266988-72uvawth 44 30 , , , cord-266988-72uvawth 44 31 platelets platelet NNS cord-266988-72uvawth 44 32 , , , cord-266988-72uvawth 44 33 and and CC cord-266988-72uvawth 44 34 neutrophils neutrophil NNS cord-266988-72uvawth 44 35 in in IN cord-266988-72uvawth 44 36 alveolar alveolar JJ cord-266988-72uvawth 44 37 capillaries capillary NNS cord-266988-72uvawth 44 38 and and CC cord-266988-72uvawth 44 39 precipitation precipitation NN cord-266988-72uvawth 44 40 of of IN cord-266988-72uvawth 44 41 fibrin fibrin NN cord-266988-72uvawth 44 42 inside inside IN cord-266988-72uvawth 44 43 and and CC cord-266988-72uvawth 44 44 outside outside IN cord-266988-72uvawth 44 45 the the DT cord-266988-72uvawth 44 46 alveolar alveolar JJ cord-266988-72uvawth 44 47 capillaries capillary NNS cord-266988-72uvawth 44 48 with with IN cord-266988-72uvawth 44 49 a a DT cord-266988-72uvawth 44 50 relatively relatively RB cord-266988-72uvawth 44 51 mild mild JJ cord-266988-72uvawth 44 52 accumulation accumulation NN cord-266988-72uvawth 44 53 of of IN cord-266988-72uvawth 44 54 lymphocytes lymphocyte NNS cord-266988-72uvawth 44 55 and and CC cord-266988-72uvawth 44 56 macrophages macrophage NNS cord-266988-72uvawth 44 57 within within IN cord-266988-72uvawth 44 58 alveoli alveolus NNS cord-266988-72uvawth 44 59 . . . cord-266988-72uvawth 45 1 The the DT cord-266988-72uvawth 45 2 former former JJ cord-266988-72uvawth 45 3 provides provide VBZ cord-266988-72uvawth 45 4 evidence evidence NN cord-266988-72uvawth 45 5 for for IN cord-266988-72uvawth 45 6 a a DT cord-266988-72uvawth 45 7 pulmonary pulmonary JJ cord-266988-72uvawth 45 8 thrombotic thrombotic JJ cord-266988-72uvawth 45 9 microangiopathy microangiopathy NN cord-266988-72uvawth 45 10 that that WDT cord-266988-72uvawth 45 11 often often RB cord-266988-72uvawth 45 12 results result VBZ cord-266988-72uvawth 45 13 in in IN cord-266988-72uvawth 45 14 fibrinplatelet fibrinplatelet JJ cord-266988-72uvawth 45 15 thrombi thrombi NN cord-266988-72uvawth 45 16 in in IN cord-266988-72uvawth 45 17 alveolar alveolar JJ cord-266988-72uvawth 45 18 capillaries capillary NNS cord-266988-72uvawth 45 19 and and CC cord-266988-72uvawth 45 20 small small JJ cord-266988-72uvawth 45 21 pulmonary pulmonary JJ cord-266988-72uvawth 45 22 arteries artery NNS cord-266988-72uvawth 45 23 . . . cord-266988-72uvawth 46 1 Similar similar JJ cord-266988-72uvawth 46 2 changes change NNS cord-266988-72uvawth 46 3 have have VBP cord-266988-72uvawth 46 4 been be VBN cord-266988-72uvawth 46 5 identified identify VBN cord-266988-72uvawth 46 6 in in IN cord-266988-72uvawth 46 7 DAD DAD NNP cord-266988-72uvawth 46 8 of of IN cord-266988-72uvawth 46 9 other other JJ cord-266988-72uvawth 46 10 etiologies etiology NNS cord-266988-72uvawth 46 11 , , , cord-266988-72uvawth 46 12 including include VBG cord-266988-72uvawth 46 13 influenza influenza NN cord-266988-72uvawth 46 14 and and CC cord-266988-72uvawth 46 15 SARS SARS NNP cord-266988-72uvawth 46 16 - - HYPH cord-266988-72uvawth 46 17 CoV CoV NNP cord-266988-72uvawth 46 18 [ [ -LRB- cord-266988-72uvawth 46 19 7 7 CD cord-266988-72uvawth 46 20 ] ] -RRB- cord-266988-72uvawth 46 21 . . . cord-266988-72uvawth 47 1 However however RB cord-266988-72uvawth 47 2 , , , cord-266988-72uvawth 47 3 the the DT cord-266988-72uvawth 47 4 changes change NNS cord-266988-72uvawth 47 5 in in IN cord-266988-72uvawth 47 6 full full JJ cord-266988-72uvawth 47 7 blown blown JJ cord-266988-72uvawth 47 8 COVID-19 COVID-19 NNP cord-266988-72uvawth 47 9 DAD DAD NNP cord-266988-72uvawth 47 10 are be VBP cord-266988-72uvawth 47 11 more more RBR cord-266988-72uvawth 47 12 extensive extensive JJ cord-266988-72uvawth 47 13 and and CC cord-266988-72uvawth 47 14 severe severe JJ cord-266988-72uvawth 47 15 , , , cord-266988-72uvawth 47 16 and and CC cord-266988-72uvawth 47 17 collectively collectively RB cord-266988-72uvawth 47 18 constitute constitute VB cord-266988-72uvawth 47 19 a a DT cord-266988-72uvawth 47 20 distinct distinct JJ cord-266988-72uvawth 47 21 and and CC cord-266988-72uvawth 47 22 characteristic characteristic JJ cord-266988-72uvawth 47 23 type type NN cord-266988-72uvawth 47 24 of of IN cord-266988-72uvawth 47 25 COVID-19 COVID-19 NNP cord-266988-72uvawth 47 26 DAD DAD NNP cord-266988-72uvawth 47 27 [ [ -LRB- cord-266988-72uvawth 47 28 13 13 CD cord-266988-72uvawth 47 29 ] ] -RRB- cord-266988-72uvawth 47 30 . . . cord-266988-72uvawth 48 1 The the DT cord-266988-72uvawth 48 2 pulmonary pulmonary JJ cord-266988-72uvawth 48 3 thrombotic thrombotic JJ cord-266988-72uvawth 48 4 microangiopathy microangiopathy NN cord-266988-72uvawth 48 5 progresses progress VBZ cord-266988-72uvawth 48 6 to to IN cord-266988-72uvawth 48 7 a a DT cord-266988-72uvawth 48 8 diffuse diffuse JJ cord-266988-72uvawth 48 9 hypercoagulable hypercoagulable JJ cord-266988-72uvawth 48 10 state state NN cord-266988-72uvawth 48 11 in in IN cord-266988-72uvawth 48 12 some some DT cord-266988-72uvawth 48 13 patients patient NNS cord-266988-72uvawth 48 14 that that WDT cord-266988-72uvawth 48 15 can can MD cord-266988-72uvawth 48 16 lead lead VB cord-266988-72uvawth 48 17 to to IN cord-266988-72uvawth 48 18 deep deep JJ cord-266988-72uvawth 48 19 vein vein NN cord-266988-72uvawth 48 20 thrombosis thrombosis NN cord-266988-72uvawth 48 21 and and CC cord-266988-72uvawth 48 22 large large JJ cord-266988-72uvawth 48 23 pulmonary pulmonary JJ cord-266988-72uvawth 48 24 thromboemboli thromboemboli NNS cord-266988-72uvawth 48 25 . . . cord-266988-72uvawth 49 1 A a DT cord-266988-72uvawth 49 2 clinical clinical JJ cord-266988-72uvawth 49 3 marker marker NN cord-266988-72uvawth 49 4 for for IN cord-266988-72uvawth 49 5 patients patient NNS cord-266988-72uvawth 49 6 at at IN cord-266988-72uvawth 49 7 risk risk NN cord-266988-72uvawth 49 8 for for IN cord-266988-72uvawth 49 9 this this DT cord-266988-72uvawth 49 10 coagulopathy coagulopathy NN cord-266988-72uvawth 49 11 is be VBZ cord-266988-72uvawth 49 12 elevated elevate VBN cord-266988-72uvawth 49 13 plasma plasma NN cord-266988-72uvawth 49 14 D d NN cord-266988-72uvawth 49 15 - - HYPH cord-266988-72uvawth 49 16 dimer dimer NN cord-266988-72uvawth 49 17 at at IN cord-266988-72uvawth 49 18 the the DT cord-266988-72uvawth 49 19 time time NN cord-266988-72uvawth 49 20 of of IN cord-266988-72uvawth 49 21 presentation presentation NN cord-266988-72uvawth 49 22 . . . cord-266988-72uvawth 50 1 A a DT cord-266988-72uvawth 50 2 postulated postulate VBN cord-266988-72uvawth 50 3 underlying underlying JJ cord-266988-72uvawth 50 4 mechanism mechanism NN cord-266988-72uvawth 50 5 for for IN cord-266988-72uvawth 50 6 severe severe JJ cord-266988-72uvawth 50 7 COVID-19 covid-19 JJ cord-266988-72uvawth 50 8 associated associated JJ cord-266988-72uvawth 50 9 pneumonia pneumonia NN cord-266988-72uvawth 50 10 is be VBZ cord-266988-72uvawth 50 11 a a DT cord-266988-72uvawth 50 12 state state NN cord-266988-72uvawth 50 13 of of IN cord-266988-72uvawth 50 14 virally virally RB cord-266988-72uvawth 50 15 - - HYPH cord-266988-72uvawth 50 16 induced induce VBN cord-266988-72uvawth 50 17 hyper hyper NN cord-266988-72uvawth 50 18 - - NN cord-266988-72uvawth 50 19 inflammation inflammation NN cord-266988-72uvawth 50 20 that that WDT cord-266988-72uvawth 50 21 has have VBZ cord-266988-72uvawth 50 22 been be VBN cord-266988-72uvawth 50 23 variously variously RB cord-266988-72uvawth 50 24 designated designate VBN cord-266988-72uvawth 50 25 as as IN cord-266988-72uvawth 50 26 macrophage macrophage NN cord-266988-72uvawth 50 27 activation activation NN cord-266988-72uvawth 50 28 syndrome syndrome NN cord-266988-72uvawth 50 29 ( ( -LRB- cord-266988-72uvawth 50 30 MAS MAS NNP cord-266988-72uvawth 50 31 ) ) -RRB- cord-266988-72uvawth 50 32 , , , cord-266988-72uvawth 50 33 cytokine cytokine JJ cord-266988-72uvawth 50 34 storm storm NN cord-266988-72uvawth 50 35 and and CC cord-266988-72uvawth 50 36 secondary secondary JJ cord-266988-72uvawth 50 37 hemophagocytic hemophagocytic NNP cord-266988-72uvawth 50 38 lymphohistocytosis lymphohistocytosis NNP cord-266988-72uvawth 50 39 ( ( -LRB- cord-266988-72uvawth 50 40 sHLH sHLH NNP cord-266988-72uvawth 50 41 ) ) -RRB- cord-266988-72uvawth 50 42 [ [ -LRB- cord-266988-72uvawth 50 43 28 28 CD cord-266988-72uvawth 50 44 , , , cord-266988-72uvawth 50 45 29 29 CD cord-266988-72uvawth 50 46 ] ] -RRB- cord-266988-72uvawth 50 47 . . . cord-266988-72uvawth 51 1 This this DT cord-266988-72uvawth 51 2 hyperinflammatory hyperinflammatory JJ cord-266988-72uvawth 51 3 response response NN cord-266988-72uvawth 51 4 most most RBS cord-266988-72uvawth 51 5 likely likely RB cord-266988-72uvawth 51 6 involves involve VBZ cord-266988-72uvawth 51 7 activation activation NN cord-266988-72uvawth 51 8 of of IN cord-266988-72uvawth 51 9 the the DT cord-266988-72uvawth 51 10 innate innate JJ cord-266988-72uvawth 51 11 and and CC cord-266988-72uvawth 51 12 acquired acquire VBD cord-266988-72uvawth 51 13 immune immune JJ cord-266988-72uvawth 51 14 systems system NNS cord-266988-72uvawth 51 15 [ [ -LRB- cord-266988-72uvawth 51 16 28 28 CD cord-266988-72uvawth 51 17 , , , cord-266988-72uvawth 51 18 29 29 CD cord-266988-72uvawth 51 19 ] ] -RRB- cord-266988-72uvawth 52 1 Hence hence RB cord-266988-72uvawth 52 2 , , , cord-266988-72uvawth 52 3 the the DT cord-266988-72uvawth 52 4 initial initial JJ cord-266988-72uvawth 52 5 pulmonary pulmonary JJ cord-266988-72uvawth 52 6 pathology pathology NN cord-266988-72uvawth 52 7 is be VBZ cord-266988-72uvawth 52 8 a a DT cord-266988-72uvawth 52 9 florid florid JJ cord-266988-72uvawth 52 10 DAD dad NN cord-266988-72uvawth 52 11 with with IN cord-266988-72uvawth 52 12 an an DT cord-266988-72uvawth 52 13 immuno immuno JJ cord-266988-72uvawth 52 14 - - JJ cord-266988-72uvawth 52 15 thrombotic thrombotic JJ cord-266988-72uvawth 52 16 microangiopathy microangiopathy NN cord-266988-72uvawth 52 17 [ [ -LRB- cord-266988-72uvawth 52 18 4 4 CD cord-266988-72uvawth 52 19 , , , cord-266988-72uvawth 52 20 28 28 CD cord-266988-72uvawth 52 21 , , , cord-266988-72uvawth 52 22 29 29 CD cord-266988-72uvawth 52 23 ] ] -RRB- cord-266988-72uvawth 52 24 . . . cord-266988-72uvawth 53 1 Patients patient NNS cord-266988-72uvawth 53 2 who who WP cord-266988-72uvawth 53 3 succumb succumb VBP cord-266988-72uvawth 53 4 after after IN cord-266988-72uvawth 53 5 a a DT cord-266988-72uvawth 53 6 more more RBR cord-266988-72uvawth 53 7 prolonged prolonged JJ cord-266988-72uvawth 53 8 clinical clinical JJ cord-266988-72uvawth 53 9 course course NN cord-266988-72uvawth 53 10 are be VBP cord-266988-72uvawth 53 11 likely likely JJ cord-266988-72uvawth 53 12 to to TO cord-266988-72uvawth 53 13 show show VB cord-266988-72uvawth 53 14 late late JJ cord-266988-72uvawth 53 15 stage stage NN cord-266988-72uvawth 54 1 DAD DAD NNP cord-266988-72uvawth 54 2 and/or and/or CC cord-266988-72uvawth 54 3 organizing organize VBG cord-266988-72uvawth 54 4 pneumonia pneumonia NN cord-266988-72uvawth 54 5 . . . cord-266988-72uvawth 55 1 Consensus consensus NN cord-266988-72uvawth 55 2 guidelines guideline NNS cord-266988-72uvawth 55 3 are be VBP cord-266988-72uvawth 55 4 now now RB cord-266988-72uvawth 55 5 available available JJ cord-266988-72uvawth 55 6 for for IN cord-266988-72uvawth 55 7 prevention prevention NN cord-266988-72uvawth 55 8 , , , cord-266988-72uvawth 55 9 antithrombotic antithrombotic JJ cord-266988-72uvawth 55 10 therapy therapy NN cord-266988-72uvawth 55 11 , , , cord-266988-72uvawth 55 12 and and CC cord-266988-72uvawth 55 13 follow follow NN cord-266988-72uvawth 55 14 - - HYPH cord-266988-72uvawth 55 15 up up NN cord-266988-72uvawth 55 16 for for IN cord-266988-72uvawth 55 17 thrombotic thrombotic JJ cord-266988-72uvawth 55 18 and and CC cord-266988-72uvawth 55 19 thromboembolic thromboembolic JJ cord-266988-72uvawth 55 20 disease disease NN cord-266988-72uvawth 55 21 in in IN cord-266988-72uvawth 55 22 COVID-19 COVID-19 NNP cord-266988-72uvawth 55 23 patients patient NNS cord-266988-72uvawth 55 24 [ [ -LRB- cord-266988-72uvawth 55 25 30 30 CD cord-266988-72uvawth 55 26 ] ] -RRB- cord-266988-72uvawth 55 27 and and CC cord-266988-72uvawth 55 28 the the DT cord-266988-72uvawth 55 29 damping damping NN cord-266988-72uvawth 55 30 of of IN cord-266988-72uvawth 55 31 the the DT cord-266988-72uvawth 55 32 hyperimmune hyperimmune NNP cord-266988-72uvawth 55 33 inflammatory inflammatory JJ cord-266988-72uvawth 55 34 response response NN cord-266988-72uvawth 55 35 by by IN cord-266988-72uvawth 55 36 the the DT cord-266988-72uvawth 55 37 administration administration NN cord-266988-72uvawth 55 38 of of IN cord-266988-72uvawth 55 39 Dexamethasone Dexamethasone NNP cord-266988-72uvawth 55 40 [ [ -LRB- cord-266988-72uvawth 55 41 31 31 CD cord-266988-72uvawth 55 42 ] ] -RRB- cord-266988-72uvawth 55 43 . . . cord-266988-72uvawth 56 1 The the DT cord-266988-72uvawth 56 2 Chinese chinese JJ cord-266988-72uvawth 56 3 clinical clinical JJ cord-266988-72uvawth 56 4 studies study NNS cord-266988-72uvawth 56 5 early early RB cord-266988-72uvawth 56 6 on on IN cord-266988-72uvawth 56 7 identified identify VBN cord-266988-72uvawth 56 8 serum serum NN cord-266988-72uvawth 56 9 troponin troponin JJ cord-266988-72uvawth 56 10 as as IN cord-266988-72uvawth 56 11 a a DT cord-266988-72uvawth 56 12 marker marker NN cord-266988-72uvawth 56 13 for for IN cord-266988-72uvawth 56 14 an an DT cord-266988-72uvawth 56 15 adverse adverse JJ cord-266988-72uvawth 56 16 outcome outcome NN cord-266988-72uvawth 56 17 and and CC cord-266988-72uvawth 56 18 this this DT cord-266988-72uvawth 56 19 led lead VBD cord-266988-72uvawth 56 20 to to IN cord-266988-72uvawth 56 21 the the DT cord-266988-72uvawth 56 22 suggestion suggestion NN cord-266988-72uvawth 56 23 of of IN cord-266988-72uvawth 56 24 a a DT cord-266988-72uvawth 56 25 myocarditis myocarditis NN cord-266988-72uvawth 56 26 [ [ -LRB- cord-266988-72uvawth 56 27 24 24 CD cord-266988-72uvawth 56 28 , , , cord-266988-72uvawth 56 29 25 25 CD cord-266988-72uvawth 56 30 ] ] -RRB- cord-266988-72uvawth 56 31 . . . cord-266988-72uvawth 57 1 However however RB cord-266988-72uvawth 57 2 , , , cord-266988-72uvawth 57 3 cardiac cardiac JJ cord-266988-72uvawth 57 4 involvement involvement NN cord-266988-72uvawth 57 5 has have VBZ cord-266988-72uvawth 57 6 proven prove VBN cord-266988-72uvawth 57 7 to to TO cord-266988-72uvawth 57 8 be be VB cord-266988-72uvawth 57 9 more more RBR cord-266988-72uvawth 57 10 subtle subtle JJ cord-266988-72uvawth 57 11 with with IN cord-266988-72uvawth 57 12 most most JJS cord-266988-72uvawth 57 13 hearts heart NNS cord-266988-72uvawth 57 14 showing show VBG cord-266988-72uvawth 57 15 multifocal multifocal JJ cord-266988-72uvawth 57 16 individual individual JJ cord-266988-72uvawth 57 17 cardiomyocyte cardiomyocyte NNP cord-266988-72uvawth 57 18 injury injury NN cord-266988-72uvawth 57 19 without without IN cord-266988-72uvawth 57 20 overt overt JJ cord-266988-72uvawth 57 21 interstitial interstitial JJ cord-266988-72uvawth 57 22 inflammation inflammation NN cord-266988-72uvawth 57 23 and and CC cord-266988-72uvawth 57 24 only only RB cord-266988-72uvawth 57 25 a a DT cord-266988-72uvawth 57 26 few few JJ cord-266988-72uvawth 57 27 cases case NNS cord-266988-72uvawth 57 28 of of IN cord-266988-72uvawth 57 29 classical classical JJ cord-266988-72uvawth 57 30 myocarditis myocarditis NN cord-266988-72uvawth 57 31 have have VBP cord-266988-72uvawth 57 32 been be VBN cord-266988-72uvawth 57 33 described describe VBN cord-266988-72uvawth 57 34 [ [ -LRB- cord-266988-72uvawth 57 35 13 13 CD cord-266988-72uvawth 57 36 ] ] -RRB- cord-266988-72uvawth 57 37 . . . cord-266988-72uvawth 58 1 The the DT cord-266988-72uvawth 58 2 pathological pathological JJ cord-266988-72uvawth 58 3 basis basis NN cord-266988-72uvawth 58 4 for for IN cord-266988-72uvawth 58 5 severe severe JJ cord-266988-72uvawth 58 6 acute acute JJ cord-266988-72uvawth 58 7 renal renal JJ cord-266988-72uvawth 58 8 failure failure NN cord-266988-72uvawth 58 9 in in IN cord-266988-72uvawth 58 10 some some DT cord-266988-72uvawth 58 11 patients patient NNS cord-266988-72uvawth 58 12 requires require VBZ cord-266988-72uvawth 58 13 further further JJ cord-266988-72uvawth 58 14 evaluation evaluation NN cord-266988-72uvawth 58 15 . . . cord-266988-72uvawth 59 1 Some some DT cord-266988-72uvawth 59 2 decedents decedent NNS cord-266988-72uvawth 59 3 had have VBD cord-266988-72uvawth 59 4 prominent prominent JJ cord-266988-72uvawth 59 5 thrombi thrombi NN cord-266988-72uvawth 59 6 in in IN cord-266988-72uvawth 59 7 glomerular glomerular JJ cord-266988-72uvawth 59 8 capillaries capillary NNS cord-266988-72uvawth 59 9 [ [ -LRB- cord-266988-72uvawth 59 10 19 19 CD cord-266988-72uvawth 59 11 ] ] -RRB- cord-266988-72uvawth 59 12 although although IN cord-266988-72uvawth 59 13 in in IN cord-266988-72uvawth 59 14 many many JJ cord-266988-72uvawth 59 15 cases case NNS cord-266988-72uvawth 59 16 , , , cord-266988-72uvawth 59 17 glomerular glomerular JJ cord-266988-72uvawth 59 18 involvement involvement NN cord-266988-72uvawth 59 19 has have VBZ cord-266988-72uvawth 59 20 been be VBN cord-266988-72uvawth 59 21 limited limit VBN cord-266988-72uvawth 59 22 . . . cord-266988-72uvawth 60 1 It -PRON- PRP cord-266988-72uvawth 60 2 is be VBZ cord-266988-72uvawth 60 3 likely likely JJ cord-266988-72uvawth 60 4 that that IN cord-266988-72uvawth 60 5 the the DT cord-266988-72uvawth 60 6 acute acute JJ cord-266988-72uvawth 60 7 renal renal JJ cord-266988-72uvawth 60 8 failure failure NN cord-266988-72uvawth 60 9 is be VBZ cord-266988-72uvawth 60 10 a a DT cord-266988-72uvawth 60 11 secondary secondary JJ cord-266988-72uvawth 60 12 form form NN cord-266988-72uvawth 60 13 of of IN cord-266988-72uvawth 60 14 acute acute JJ cord-266988-72uvawth 60 15 tubular tubular JJ cord-266988-72uvawth 60 16 necrosis necrosis NN cord-266988-72uvawth 60 17 [ [ -LRB- cord-266988-72uvawth 60 18 19 19 CD cord-266988-72uvawth 60 19 ] ] -RRB- cord-266988-72uvawth 60 20 . . . cord-266988-72uvawth 61 1 The the DT cord-266988-72uvawth 61 2 spleen spleen NN cord-266988-72uvawth 61 3 has have VBZ cord-266988-72uvawth 61 4 been be VBN cord-266988-72uvawth 61 5 found find VBN cord-266988-72uvawth 61 6 to to TO cord-266988-72uvawth 61 7 have have VB cord-266988-72uvawth 61 8 a a DT cord-266988-72uvawth 61 9 dimunition dimunition NN cord-266988-72uvawth 61 10 of of IN cord-266988-72uvawth 61 11 white white JJ cord-266988-72uvawth 61 12 pulp pulp NN cord-266988-72uvawth 61 13 with with IN cord-266988-72uvawth 61 14 loss loss NN cord-266988-72uvawth 61 15 of of IN cord-266988-72uvawth 61 16 peripheral peripheral JJ cord-266988-72uvawth 61 17 cuff cuff NN cord-266988-72uvawth 61 18 lymphocytes lymphocyte NNS cord-266988-72uvawth 61 19 . . . cord-266988-72uvawth 62 1 This this DT cord-266988-72uvawth 62 2 is be VBZ cord-266988-72uvawth 62 3 consistent consistent JJ cord-266988-72uvawth 62 4 with with IN cord-266988-72uvawth 62 5 a a DT cord-266988-72uvawth 62 6 viral viral JJ cord-266988-72uvawth 62 7 attack attack NN cord-266988-72uvawth 62 8 on on IN cord-266988-72uvawth 62 9 immunocytes immunocyte NNS cord-266988-72uvawth 62 10 and and CC cord-266988-72uvawth 62 11 the the DT cord-266988-72uvawth 62 12 lymphopenia lymphopenia NNP cord-266988-72uvawth 62 13 that that WDT cord-266988-72uvawth 62 14 may may MD cord-266988-72uvawth 62 15 be be VB cord-266988-72uvawth 62 16 seen see VBN cord-266988-72uvawth 62 17 at at IN cord-266988-72uvawth 62 18 the the DT cord-266988-72uvawth 62 19 time time NN cord-266988-72uvawth 62 20 of of IN cord-266988-72uvawth 62 21 presentation presentation NN cord-266988-72uvawth 62 22 . . . cord-266988-72uvawth 63 1 Hemophagocytic hemophagocytic JJ cord-266988-72uvawth 63 2 lymphohistiocytosis lymphohistiocytosis NN cord-266988-72uvawth 63 3 ( ( -LRB- cord-266988-72uvawth 63 4 HLH HLH NNP cord-266988-72uvawth 63 5 ) ) -RRB- cord-266988-72uvawth 63 6 has have VBZ cord-266988-72uvawth 63 7 been be VBN cord-266988-72uvawth 63 8 postulated postulate VBN cord-266988-72uvawth 63 9 to to TO cord-266988-72uvawth 63 10 have have VB cord-266988-72uvawth 63 11 an an DT cord-266988-72uvawth 63 12 important important JJ cord-266988-72uvawth 63 13 role role NN cord-266988-72uvawth 63 14 in in IN cord-266988-72uvawth 63 15 the the DT cord-266988-72uvawth 63 16 progression progression NN cord-266988-72uvawth 63 17 of of IN cord-266988-72uvawth 63 18 severe severe JJ cord-266988-72uvawth 63 19 COVID-19 covid-19 JJ cord-266988-72uvawth 63 20 disease disease NN cord-266988-72uvawth 63 21 [ [ -LRB- cord-266988-72uvawth 63 22 28 28 CD cord-266988-72uvawth 63 23 , , , cord-266988-72uvawth 63 24 29 29 CD cord-266988-72uvawth 63 25 ] ] -RRB- cord-266988-72uvawth 63 26 . . . cord-266988-72uvawth 64 1 However however RB cord-266988-72uvawth 64 2 , , , cord-266988-72uvawth 64 3 so so RB cord-266988-72uvawth 64 4 far far RB cord-266988-72uvawth 64 5 morphological morphological JJ cord-266988-72uvawth 64 6 evidence evidence NN cord-266988-72uvawth 64 7 of of IN cord-266988-72uvawth 64 8 prominent prominent JJ cord-266988-72uvawth 64 9 erythrophagocytosis erythrophagocytosis NNP cord-266988-72uvawth 64 10 has have VBZ cord-266988-72uvawth 64 11 been be VBN cord-266988-72uvawth 64 12 found find VBN cord-266988-72uvawth 64 13 in in IN cord-266988-72uvawth 64 14 only only RB cord-266988-72uvawth 64 15 a a DT cord-266988-72uvawth 64 16 few few JJ cord-266988-72uvawth 64 17 cases case NNS cord-266988-72uvawth 64 18 [ [ -LRB- cord-266988-72uvawth 64 19 12 12 CD cord-266988-72uvawth 64 20 ] ] -RRB- cord-266988-72uvawth 64 21 . . . cord-266988-72uvawth 65 1 Of of IN cord-266988-72uvawth 65 2 special special JJ cord-266988-72uvawth 65 3 interest interest NN cord-266988-72uvawth 65 4 is be VBZ cord-266988-72uvawth 65 5 involvement involvement NN cord-266988-72uvawth 65 6 of of IN cord-266988-72uvawth 65 7 the the DT cord-266988-72uvawth 65 8 brain brain NN cord-266988-72uvawth 65 9 in in IN cord-266988-72uvawth 65 10 individuals individual NNS cord-266988-72uvawth 65 11 infected infect VBN cord-266988-72uvawth 65 12 by by IN cord-266988-72uvawth 65 13 COVID-19 COVID-19 NNP cord-266988-72uvawth 65 14 . . . cord-266988-72uvawth 66 1 There there EX cord-266988-72uvawth 66 2 certainly certainly RB cord-266988-72uvawth 66 3 was be VBD cord-266988-72uvawth 66 4 a a DT cord-266988-72uvawth 66 5 hint hint NN cord-266988-72uvawth 66 6 of of IN cord-266988-72uvawth 66 7 this this DT cord-266988-72uvawth 66 8 in in IN cord-266988-72uvawth 66 9 the the DT cord-266988-72uvawth 66 10 very very RB cord-266988-72uvawth 66 11 common common JJ cord-266988-72uvawth 66 12 presenting present VBG cord-266988-72uvawth 66 13 symptoms symptom NNS cord-266988-72uvawth 66 14 of of IN cord-266988-72uvawth 66 15 anosmia anosmia NN cord-266988-72uvawth 66 16 and and CC cord-266988-72uvawth 66 17 ageusia ageusia NNP cord-266988-72uvawth 66 18 suggesting suggest VBG cord-266988-72uvawth 66 19 the the DT cord-266988-72uvawth 66 20 neurotropism neurotropism NN cord-266988-72uvawth 66 21 of of IN cord-266988-72uvawth 66 22 the the DT cord-266988-72uvawth 66 23 virus virus NN cord-266988-72uvawth 66 24 . . . cord-266988-72uvawth 67 1 Magnetic magnetic JJ cord-266988-72uvawth 67 2 resonance resonance NN cord-266988-72uvawth 67 3 imaging imaging NN cord-266988-72uvawth 67 4 of of IN cord-266988-72uvawth 67 5 the the DT cord-266988-72uvawth 67 6 brain brain NN cord-266988-72uvawth 67 7 of of IN cord-266988-72uvawth 67 8 one one CD cord-266988-72uvawth 67 9 patient patient NN cord-266988-72uvawth 67 10 with with IN cord-266988-72uvawth 67 11 these these DT cord-266988-72uvawth 67 12 two two CD cord-266988-72uvawth 67 13 symptoms symptom NNS cord-266988-72uvawth 67 14 revealed reveal VBD cord-266988-72uvawth 67 15 abnormalities abnormality NNS cord-266988-72uvawth 67 16 in in IN cord-266988-72uvawth 67 17 the the DT cord-266988-72uvawth 67 18 right right JJ cord-266988-72uvawth 67 19 gyrus gyrus NNP cord-266988-72uvawth 67 20 rectus rectus NN cord-266988-72uvawth 67 21 and and CC cord-266988-72uvawth 67 22 the the DT cord-266988-72uvawth 67 23 olfactory olfactory JJ cord-266988-72uvawth 67 24 bulbs bulb NNS cord-266988-72uvawth 67 25 [ [ -LRB- cord-266988-72uvawth 67 26 32 32 CD cord-266988-72uvawth 67 27 ] ] -RRB- cord-266988-72uvawth 67 28 . . . cord-266988-72uvawth 68 1 Even even RB cord-266988-72uvawth 68 2 more more RBR cord-266988-72uvawth 68 3 striking striking JJ cord-266988-72uvawth 68 4 has have VBZ cord-266988-72uvawth 68 5 been be VBN cord-266988-72uvawth 68 6 numerous numerous JJ cord-266988-72uvawth 68 7 reports report NNS cord-266988-72uvawth 68 8 of of IN cord-266988-72uvawth 68 9 individuals individual NNS cord-266988-72uvawth 68 10 with with IN cord-266988-72uvawth 68 11 COVID-19 covid-19 JJ cord-266988-72uvawth 68 12 infection infection NN cord-266988-72uvawth 68 13 who who WP cord-266988-72uvawth 68 14 have have VBP cord-266988-72uvawth 68 15 had have VBN cord-266988-72uvawth 68 16 strokes stroke NNS cord-266988-72uvawth 68 17 , , , cord-266988-72uvawth 68 18 and and CC cord-266988-72uvawth 68 19 in in IN cord-266988-72uvawth 68 20 some some DT cord-266988-72uvawth 68 21 instances instance NNS cord-266988-72uvawth 68 22 these these DT cord-266988-72uvawth 68 23 were be VBD cord-266988-72uvawth 68 24 the the DT cord-266988-72uvawth 68 25 presenting present VBG cord-266988-72uvawth 68 26 symptom symptom NN cord-266988-72uvawth 68 27 . . . cord-266988-72uvawth 69 1 Bryce Bryce NNP cord-266988-72uvawth 69 2 et et NNP cord-266988-72uvawth 69 3 al al NNP cord-266988-72uvawth 69 4 . . NNP cord-266988-72uvawth 69 5 have have VBP cord-266988-72uvawth 69 6 reported report VBN cord-266988-72uvawth 69 7 that that IN cord-266988-72uvawth 69 8 6 6 CD cord-266988-72uvawth 69 9 of of IN cord-266988-72uvawth 69 10 20 20 CD cord-266988-72uvawth 69 11 brains brain NNS cord-266988-72uvawth 69 12 that that WDT cord-266988-72uvawth 69 13 were be VBD cord-266988-72uvawth 69 14 examined examine VBN cord-266988-72uvawth 69 15 showed show VBN cord-266988-72uvawth 69 16 a a DT cord-266988-72uvawth 69 17 range range NN cord-266988-72uvawth 69 18 of of IN cord-266988-72uvawth 69 19 abnormal abnormal JJ cord-266988-72uvawth 69 20 pathologic pathologic JJ cord-266988-72uvawth 69 21 findings finding NNS cord-266988-72uvawth 69 22 , , , cord-266988-72uvawth 69 23 the the DT cord-266988-72uvawth 69 24 most most RBS cord-266988-72uvawth 69 25 striking striking JJ cord-266988-72uvawth 69 26 of of IN cord-266988-72uvawth 69 27 which which WDT cord-266988-72uvawth 69 28 was be VBD cord-266988-72uvawth 69 29 the the DT cord-266988-72uvawth 69 30 presence presence NN cord-266988-72uvawth 69 31 of of IN cord-266988-72uvawth 69 32 microthrombi microthrombi NNP cord-266988-72uvawth 69 33 and and CC cord-266988-72uvawth 69 34 acute acute JJ cord-266988-72uvawth 69 35 infarcts infarct NNS cord-266988-72uvawth 69 36 in in IN cord-266988-72uvawth 69 37 the the DT cord-266988-72uvawth 69 38 brains brain NNS cord-266988-72uvawth 69 39 that that WDT cord-266988-72uvawth 69 40 were be VBD cord-266988-72uvawth 69 41 examined examine VBN cord-266988-72uvawth 69 42 . . . cord-266988-72uvawth 70 1 In in IN cord-266988-72uvawth 70 2 some some DT cord-266988-72uvawth 70 3 brains brain NNS cord-266988-72uvawth 70 4 this this DT cord-266988-72uvawth 70 5 was be VBD cord-266988-72uvawth 70 6 accompanied accompany VBN cord-266988-72uvawth 70 7 by by IN cord-266988-72uvawth 70 8 acute acute JJ cord-266988-72uvawth 70 9 parenchymal parenchymal NN cord-266988-72uvawth 70 10 microthemorrhages microthemorrhage NNS cord-266988-72uvawth 70 11 in in IN cord-266988-72uvawth 70 12 areas area NNS cord-266988-72uvawth 70 13 of of IN cord-266988-72uvawth 70 14 necrotic necrotic JJ cord-266988-72uvawth 70 15 infarcts infarct NNS cord-266988-72uvawth 70 16 , , , cord-266988-72uvawth 70 17 which which WDT cord-266988-72uvawth 70 18 may may MD cord-266988-72uvawth 70 19 be be VB cord-266988-72uvawth 70 20 due due JJ cord-266988-72uvawth 70 21 to to IN cord-266988-72uvawth 70 22 the the DT cord-266988-72uvawth 70 23 high high JJ cord-266988-72uvawth 70 24 expression expression NN cord-266988-72uvawth 70 25 of of IN cord-266988-72uvawth 70 26 ACE2 ACE2 NNP cord-266988-72uvawth 70 27 in in IN cord-266988-72uvawth 70 28 vascular vascular JJ cord-266988-72uvawth 70 29 endothelium endothelium NN cord-266988-72uvawth 70 30 , , , cord-266988-72uvawth 70 31 not not RB cord-266988-72uvawth 70 32 only only RB cord-266988-72uvawth 70 33 in in IN cord-266988-72uvawth 70 34 the the DT cord-266988-72uvawth 70 35 brain brain NN cord-266988-72uvawth 70 36 [ [ -LRB- cord-266988-72uvawth 70 37 33 33 CD cord-266988-72uvawth 70 38 ] ] -RRB- cord-266988-72uvawth 70 39 but but CC cord-266988-72uvawth 70 40 also also RB cord-266988-72uvawth 70 41 in in IN cord-266988-72uvawth 70 42 the the DT cord-266988-72uvawth 70 43 lungs lung NNS cord-266988-72uvawth 70 44 . . . cord-266988-72uvawth 71 1 In in IN cord-266988-72uvawth 71 2 contrast contrast NN cord-266988-72uvawth 71 3 to to IN cord-266988-72uvawth 71 4 these these DT cord-266988-72uvawth 71 5 findings finding NNS cord-266988-72uvawth 71 6 , , , cord-266988-72uvawth 71 7 Solomon Solomon NNP cord-266988-72uvawth 71 8 et et NNP cord-266988-72uvawth 71 9 al al NNP cord-266988-72uvawth 71 10 . . . cord-266988-72uvawth 72 1 [ [ -LRB- cord-266988-72uvawth 72 2 34 34 CD cord-266988-72uvawth 72 3 ] ] -RRB- cord-266988-72uvawth 72 4 have have VBP cord-266988-72uvawth 72 5 reported report VBN cord-266988-72uvawth 72 6 that that IN cord-266988-72uvawth 72 7 neuropathologic neuropathologic JJ cord-266988-72uvawth 72 8 examination examination NN cord-266988-72uvawth 72 9 of of IN cord-266988-72uvawth 72 10 the the DT cord-266988-72uvawth 72 11 brains brain NNS cord-266988-72uvawth 72 12 of of IN cord-266988-72uvawth 72 13 18 18 CD cord-266988-72uvawth 72 14 decedents decedent NNS cord-266988-72uvawth 72 15 failed fail VBD cord-266988-72uvawth 72 16 to to TO cord-266988-72uvawth 72 17 reveal reveal VB cord-266988-72uvawth 72 18 any any DT cord-266988-72uvawth 72 19 changes change NNS cord-266988-72uvawth 72 20 that that WDT cord-266988-72uvawth 72 21 could could MD cord-266988-72uvawth 72 22 specifically specifically RB cord-266988-72uvawth 72 23 be be VB cord-266988-72uvawth 72 24 related relate VBN cord-266988-72uvawth 72 25 to to IN cord-266988-72uvawth 72 26 COVID-19 covid-19 JJ cord-266988-72uvawth 72 27 infection infection NN cord-266988-72uvawth 72 28 . . . cord-266988-72uvawth 73 1 However however RB cord-266988-72uvawth 73 2 , , , cord-266988-72uvawth 73 3 if if IN cord-266988-72uvawth 73 4 COVID-19 COVID-19 NNP cord-266988-72uvawth 73 5 is be VBZ cord-266988-72uvawth 73 6 anything anything NN cord-266988-72uvawth 73 7 like like IN cord-266988-72uvawth 73 8 SARS SARS NNP cord-266988-72uvawth 73 9 - - HYPH cord-266988-72uvawth 73 10 CoV CoV NNP cord-266988-72uvawth 73 11 [ [ -LRB- cord-266988-72uvawth 73 12 7 7 CD cord-266988-72uvawth 73 13 ] ] -RRB- cord-266988-72uvawth 73 14 , , , cord-266988-72uvawth 73 15 then then RB cord-266988-72uvawth 73 16 the the DT cord-266988-72uvawth 73 17 possibility possibility NN cord-266988-72uvawth 73 18 of of IN cord-266988-72uvawth 73 19 neuronal neuronal JJ cord-266988-72uvawth 73 20 infection infection NN cord-266988-72uvawth 73 21 also also RB cord-266988-72uvawth 73 22 must must MD cord-266988-72uvawth 73 23 be be VB cord-266988-72uvawth 73 24 considered consider VBN cord-266988-72uvawth 73 25 . . . cord-266988-72uvawth 74 1 More more RBR cord-266988-72uvawth 74 2 detailed detailed JJ cord-266988-72uvawth 74 3 neuropathologic neuropathologic JJ cord-266988-72uvawth 74 4 examination examination NN cord-266988-72uvawth 74 5 of of IN cord-266988-72uvawth 74 6 a a DT cord-266988-72uvawth 74 7 larger large JJR cord-266988-72uvawth 74 8 number number NN cord-266988-72uvawth 74 9 of of IN cord-266988-72uvawth 74 10 decedents decedent NNS cord-266988-72uvawth 74 11 with with IN cord-266988-72uvawth 74 12 a a DT cord-266988-72uvawth 74 13 broader broad JJR cord-266988-72uvawth 74 14 representation representation NN cord-266988-72uvawth 74 15 in in IN cord-266988-72uvawth 74 16 age age NN cord-266988-72uvawth 74 17 , , , cord-266988-72uvawth 74 18 gender gender NN cord-266988-72uvawth 74 19 , , , cord-266988-72uvawth 74 20 and and CC cord-266988-72uvawth 74 21 duration duration NN cord-266988-72uvawth 74 22 of of IN cord-266988-72uvawth 74 23 clinical clinical JJ cord-266988-72uvawth 74 24 course course NN cord-266988-72uvawth 74 25 should should MD cord-266988-72uvawth 74 26 provide provide VB cord-266988-72uvawth 74 27 a a DT cord-266988-72uvawth 74 28 more more RBR cord-266988-72uvawth 74 29 definitive definitive JJ cord-266988-72uvawth 74 30 answer answer NN cord-266988-72uvawth 74 31 to to IN cord-266988-72uvawth 74 32 the the DT cord-266988-72uvawth 74 33 question question NN cord-266988-72uvawth 74 34 of of IN cord-266988-72uvawth 74 35 brain brain NN cord-266988-72uvawth 74 36 involvement involvement NN cord-266988-72uvawth 74 37 . . . cord-266988-72uvawth 75 1 Finally finally RB cord-266988-72uvawth 75 2 , , , cord-266988-72uvawth 75 3 the the DT cord-266988-72uvawth 75 4 involvement involvement NN cord-266988-72uvawth 75 5 of of IN cord-266988-72uvawth 75 6 other other JJ cord-266988-72uvawth 75 7 organ organ NN cord-266988-72uvawth 75 8 sites site NNS cord-266988-72uvawth 75 9 such such JJ cord-266988-72uvawth 75 10 as as IN cord-266988-72uvawth 75 11 the the DT cord-266988-72uvawth 75 12 testes testis NNS cord-266988-72uvawth 75 13 , , , cord-266988-72uvawth 75 14 gastro gastro JJ cord-266988-72uvawth 75 15 - - JJ cord-266988-72uvawth 75 16 intestinal intestinal JJ cord-266988-72uvawth 75 17 tract tract NN cord-266988-72uvawth 75 18 , , , cord-266988-72uvawth 75 19 liver liver NN cord-266988-72uvawth 75 20 , , , cord-266988-72uvawth 75 21 endocrine endocrine NN cord-266988-72uvawth 75 22 system system NN cord-266988-72uvawth 75 23 and and CC cord-266988-72uvawth 75 24 musculo musculo JJ cord-266988-72uvawth 75 25 - - JJ cord-266988-72uvawth 75 26 skeletal skeletal JJ cord-266988-72uvawth 75 27 system system NN cord-266988-72uvawth 75 28 are be VBP cord-266988-72uvawth 75 29 yet yet RB cord-266988-72uvawth 75 30 to to TO cord-266988-72uvawth 75 31 be be VB cord-266988-72uvawth 75 32 determined determine VBN cord-266988-72uvawth 75 33 . . . cord-266988-72uvawth 76 1 We -PRON- PRP cord-266988-72uvawth 76 2 still still RB cord-266988-72uvawth 76 3 are be VBP cord-266988-72uvawth 76 4 at at IN cord-266988-72uvawth 76 5 an an DT cord-266988-72uvawth 76 6 early early JJ cord-266988-72uvawth 76 7 stage stage NN cord-266988-72uvawth 76 8 of of IN cord-266988-72uvawth 76 9 understanding understand VBG cord-266988-72uvawth 76 10 the the DT cord-266988-72uvawth 76 11 effects effect NNS cord-266988-72uvawth 76 12 of of IN cord-266988-72uvawth 76 13 COVID-19 covid-19 NN cord-266988-72uvawth 76 14 on on IN cord-266988-72uvawth 76 15 the the DT cord-266988-72uvawth 76 16 immune immune JJ cord-266988-72uvawth 76 17 system system NN cord-266988-72uvawth 76 18 but but CC cord-266988-72uvawth 76 19 clearly clearly RB cord-266988-72uvawth 76 20 this this DT cord-266988-72uvawth 76 21 is be VBZ cord-266988-72uvawth 76 22 of of IN cord-266988-72uvawth 76 23 great great JJ cord-266988-72uvawth 76 24 importance importance NN cord-266988-72uvawth 76 25 considering consider VBG cord-266988-72uvawth 76 26 the the DT cord-266988-72uvawth 76 27 occurrence occurrence NN cord-266988-72uvawth 76 28 of of IN cord-266988-72uvawth 76 29 a a DT cord-266988-72uvawth 76 30 hyperactive hyperactive JJ cord-266988-72uvawth 76 31 immune immune JJ cord-266988-72uvawth 76 32 response response NN cord-266988-72uvawth 76 33 to to IN cord-266988-72uvawth 76 34 the the DT cord-266988-72uvawth 76 35 virus virus NN cord-266988-72uvawth 76 36 [ [ -LRB- cord-266988-72uvawth 76 37 28 28 CD cord-266988-72uvawth 76 38 , , , cord-266988-72uvawth 76 39 29 29 CD cord-266988-72uvawth 76 40 ] ] -RRB- cord-266988-72uvawth 76 41 . . . cord-266988-72uvawth 77 1 The the DT cord-266988-72uvawth 77 2 autopsy autopsy JJ cord-266988-72uvawth 77 3 reports report VBZ cord-266988-72uvawth 77 4 that that WDT cord-266988-72uvawth 77 5 already already RB cord-266988-72uvawth 77 6 have have VBP cord-266988-72uvawth 77 7 been be VBN cord-266988-72uvawth 77 8 published publish VBN cord-266988-72uvawth 77 9 provide provide VB cord-266988-72uvawth 77 10 a a DT cord-266988-72uvawth 77 11 solid solid JJ cord-266988-72uvawth 77 12 base base NN cord-266988-72uvawth 77 13 for for IN cord-266988-72uvawth 77 14 a a DT cord-266988-72uvawth 77 15 better well JJR cord-266988-72uvawth 77 16 understanding understanding NN cord-266988-72uvawth 77 17 of of IN cord-266988-72uvawth 77 18 the the DT cord-266988-72uvawth 77 19 consequences consequence NNS cord-266988-72uvawth 77 20 of of IN cord-266988-72uvawth 77 21 COVID-19 covid-19 JJ cord-266988-72uvawth 77 22 infection infection NN cord-266988-72uvawth 77 23 but but CC cord-266988-72uvawth 77 24 much much RB cord-266988-72uvawth 77 25 more more JJR cord-266988-72uvawth 77 26 remains remain NNS cord-266988-72uvawth 77 27 to to TO cord-266988-72uvawth 77 28 be be VB cord-266988-72uvawth 77 29 learned learn VBN cord-266988-72uvawth 77 30 about about IN cord-266988-72uvawth 77 31 this this DT cord-266988-72uvawth 77 32 complex complex JJ cord-266988-72uvawth 77 33 disease disease NN cord-266988-72uvawth 77 34 in in IN cord-266988-72uvawth 77 35 order order NN cord-266988-72uvawth 77 36 to to TO cord-266988-72uvawth 77 37 develop develop VB cord-266988-72uvawth 77 38 better well JJR cord-266988-72uvawth 77 39 treatment treatment NN cord-266988-72uvawth 77 40 strategies strategy NNS cord-266988-72uvawth 77 41 . . . cord-266988-72uvawth 78 1 This this DT cord-266988-72uvawth 78 2 includes include VBZ cord-266988-72uvawth 78 3 a a DT cord-266988-72uvawth 78 4 better well JJR cord-266988-72uvawth 78 5 understanding understanding NN cord-266988-72uvawth 78 6 of of IN cord-266988-72uvawth 78 7 the the DT cord-266988-72uvawth 78 8 epidemiology epidemiology NN cord-266988-72uvawth 78 9 , , , cord-266988-72uvawth 78 10 pathology pathology NN cord-266988-72uvawth 78 11 , , , cord-266988-72uvawth 78 12 molecular molecular JJ cord-266988-72uvawth 78 13 profile profile NN cord-266988-72uvawth 78 14 and and CC cord-266988-72uvawth 78 15 immunology immunology NN cord-266988-72uvawth 78 16 of of IN cord-266988-72uvawth 78 17 the the DT cord-266988-72uvawth 78 18 virus virus NN cord-266988-72uvawth 78 19 and and CC cord-266988-72uvawth 78 20 the the DT cord-266988-72uvawth 78 21 need need NN cord-266988-72uvawth 78 22 for for IN cord-266988-72uvawth 78 23 better well JJR cord-266988-72uvawth 78 24 diagnostic diagnostic JJ cord-266988-72uvawth 78 25 tests test NNS cord-266988-72uvawth 78 26 including include VBG cord-266988-72uvawth 78 27 serological serological JJ cord-266988-72uvawth 78 28 assays assay NNS cord-266988-72uvawth 78 29 to to TO cord-266988-72uvawth 78 30 monitor monitor VB cord-266988-72uvawth 78 31 the the DT cord-266988-72uvawth 78 32 host host NN cord-266988-72uvawth 78 33 response response NN cord-266988-72uvawth 78 34 to to IN cord-266988-72uvawth 78 35 the the DT cord-266988-72uvawth 78 36 virus virus NN cord-266988-72uvawth 78 37 , , , cord-266988-72uvawth 78 38 recovery recovery NN cord-266988-72uvawth 78 39 and and CC cord-266988-72uvawth 78 40 the the DT cord-266988-72uvawth 78 41 persistence persistence NN cord-266988-72uvawth 78 42 of of IN cord-266988-72uvawth 78 43 disease disease NN cord-266988-72uvawth 78 44 in in IN cord-266988-72uvawth 78 45 infected infected JJ cord-266988-72uvawth 78 46 individuals individual NNS cord-266988-72uvawth 78 47 . . . cord-266988-72uvawth 79 1 All all DT cord-266988-72uvawth 79 2 of of IN cord-266988-72uvawth 79 3 these these DT cord-266988-72uvawth 79 4 would would MD cord-266988-72uvawth 79 5 help help VB cord-266988-72uvawth 79 6 in in IN cord-266988-72uvawth 79 7 the the DT cord-266988-72uvawth 79 8 design design NN cord-266988-72uvawth 79 9 of of IN cord-266988-72uvawth 79 10 better well JJR cord-266988-72uvawth 79 11 therapeutics therapeutic NNS cord-266988-72uvawth 79 12 and and CC cord-266988-72uvawth 79 13 vaccines vaccine NNS cord-266988-72uvawth 79 14 [ [ -LRB- cord-266988-72uvawth 79 15 35 35 CD cord-266988-72uvawth 79 16 , , , cord-266988-72uvawth 79 17 36 36 CD cord-266988-72uvawth 79 18 ] ] -RRB- cord-266988-72uvawth 79 19 . . . cord-266988-72uvawth 80 1 In in IN cord-266988-72uvawth 80 2 closing closing NN cord-266988-72uvawth 80 3 , , , cord-266988-72uvawth 80 4 this this DT cord-266988-72uvawth 80 5 editorial editorial NN cord-266988-72uvawth 80 6 announces announce VBZ cord-266988-72uvawth 80 7 the the DT cord-266988-72uvawth 80 8 inauguration inauguration NN cord-266988-72uvawth 80 9 of of IN cord-266988-72uvawth 80 10 a a DT cord-266988-72uvawth 80 11 new new JJ cord-266988-72uvawth 80 12 thematic thematic JJ cord-266988-72uvawth 80 13 series series NN cord-266988-72uvawth 80 14 on on IN cord-266988-72uvawth 80 15 the the DT cord-266988-72uvawth 80 16 pathological pathological JJ cord-266988-72uvawth 80 17 spectrum spectrum NN cord-266988-72uvawth 80 18 and and CC cord-266988-72uvawth 80 19 pathogenesis pathogenesis NN cord-266988-72uvawth 80 20 of of IN cord-266988-72uvawth 80 21 SARS SARS NNP cord-266988-72uvawth 80 22 - - HYPH cord-266988-72uvawth 80 23 CoV-2 CoV-2 NNP cord-266988-72uvawth 80 24 . . . cord-266988-72uvawth 81 1 As as IN cord-266988-72uvawth 81 2 the the DT cord-266988-72uvawth 81 3 editor editor NN cord-266988-72uvawth 81 4 - - HYPH cord-266988-72uvawth 81 5 in in IN cord-266988-72uvawth 81 6 - - HYPH cord-266988-72uvawth 81 7 chief chief NN cord-266988-72uvawth 81 8 of of IN cord-266988-72uvawth 81 9 Diagnostic Diagnostic NNP cord-266988-72uvawth 81 10 Pathology Pathology NNP cord-266988-72uvawth 81 11 , , , cord-266988-72uvawth 81 12 I -PRON- PRP cord-266988-72uvawth 81 13 , , , cord-266988-72uvawth 81 14 Anil Anil NNP cord-266988-72uvawth 81 15 Parwani Parwani NNP cord-266988-72uvawth 81 16 , , , cord-266988-72uvawth 81 17 am be VBP cord-266988-72uvawth 81 18 very very RB cord-266988-72uvawth 81 19 excited excited JJ cord-266988-72uvawth 81 20 about about IN cord-266988-72uvawth 81 21 launching launch VBG cord-266988-72uvawth 81 22 this this DT cord-266988-72uvawth 81 23 important important JJ cord-266988-72uvawth 81 24 series series NN cord-266988-72uvawth 81 25 as as IN cord-266988-72uvawth 81 26 it -PRON- PRP cord-266988-72uvawth 81 27 will will MD cord-266988-72uvawth 81 28 serve serve VB cord-266988-72uvawth 81 29 to to TO cord-266988-72uvawth 81 30 attract attract VB cord-266988-72uvawth 81 31 key key JJ cord-266988-72uvawth 81 32 articles article NNS cord-266988-72uvawth 81 33 in in IN cord-266988-72uvawth 81 34 COVID-19 covid-19 JJ cord-266988-72uvawth 81 35 pathophysiology pathophysiology NN cord-266988-72uvawth 81 36 , , , cord-266988-72uvawth 81 37 diagnostics diagnostic NNS cord-266988-72uvawth 81 38 , , , cord-266988-72uvawth 81 39 molecular molecular JJ cord-266988-72uvawth 81 40 pathology pathology NN cord-266988-72uvawth 81 41 , , , cord-266988-72uvawth 81 42 immunology immunology NN cord-266988-72uvawth 81 43 with with IN cord-266988-72uvawth 81 44 an an DT cord-266988-72uvawth 81 45 emphasis emphasis NN cord-266988-72uvawth 81 46 on on IN cord-266988-72uvawth 81 47 the the DT cord-266988-72uvawth 81 48 cliniopathological cliniopathological JJ cord-266988-72uvawth 81 49 correlation correlation NN cord-266988-72uvawth 81 50 of of IN cord-266988-72uvawth 81 51 this this DT cord-266988-72uvawth 81 52 disease disease NN cord-266988-72uvawth 81 53 . . . cord-266988-72uvawth 82 1 The the DT cord-266988-72uvawth 82 2 series series NN cord-266988-72uvawth 82 3 will will MD cord-266988-72uvawth 82 4 also also RB cord-266988-72uvawth 82 5 solicit solicit VB cord-266988-72uvawth 82 6 articles article NNS cord-266988-72uvawth 82 7 on on IN cord-266988-72uvawth 82 8 the the DT cord-266988-72uvawth 82 9 most most JJS cord-266988-72uvawth 82 10 up up IN cord-266988-72uvawth 82 11 to to IN cord-266988-72uvawth 82 12 date date NN cord-266988-72uvawth 82 13 understanding understanding NN cord-266988-72uvawth 82 14 of of IN cord-266988-72uvawth 82 15 the the DT cord-266988-72uvawth 82 16 histopathological histopathological JJ cord-266988-72uvawth 82 17 features feature NNS cord-266988-72uvawth 82 18 of of IN cord-266988-72uvawth 82 19 a a DT cord-266988-72uvawth 82 20 SARS SARS NNP cord-266988-72uvawth 82 21 - - HYPH cord-266988-72uvawth 82 22 CoV-2 CoV-2 NNP cord-266988-72uvawth 82 23 infection infection NN cord-266988-72uvawth 82 24 including include VBG cord-266988-72uvawth 82 25 an an DT cord-266988-72uvawth 82 26 understanding understanding NN cord-266988-72uvawth 82 27 of of IN cord-266988-72uvawth 82 28 the the DT cord-266988-72uvawth 82 29 ultrastructure ultrastructure NN cord-266988-72uvawth 82 30 of of IN cord-266988-72uvawth 82 31 the the DT cord-266988-72uvawth 82 32 virus virus NN cord-266988-72uvawth 82 33 . . . cord-266988-72uvawth 83 1 We -PRON- PRP cord-266988-72uvawth 83 2 hope hope VBP cord-266988-72uvawth 83 3 that that IN cord-266988-72uvawth 83 4 our -PRON- PRP$ cord-266988-72uvawth 83 5 readers reader NNS cord-266988-72uvawth 83 6 will will MD cord-266988-72uvawth 83 7 find find VB cord-266988-72uvawth 83 8 the the DT cord-266988-72uvawth 83 9 collection collection NN cord-266988-72uvawth 83 10 of of IN cord-266988-72uvawth 83 11 articles article NNS cord-266988-72uvawth 83 12 in in IN cord-266988-72uvawth 83 13 this this DT cord-266988-72uvawth 83 14 series series NN cord-266988-72uvawth 83 15 both both DT cord-266988-72uvawth 83 16 interesting interesting JJ cord-266988-72uvawth 83 17 and and CC cord-266988-72uvawth 83 18 useful useful JJ cord-266988-72uvawth 83 19 in in IN cord-266988-72uvawth 83 20 disseminating disseminate VBG cord-266988-72uvawth 83 21 important important JJ cord-266988-72uvawth 83 22 information information NN cord-266988-72uvawth 83 23 relating relate VBG cord-266988-72uvawth 83 24 to to IN cord-266988-72uvawth 83 25 the the DT cord-266988-72uvawth 83 26 pathology pathology NN cord-266988-72uvawth 83 27 of of IN cord-266988-72uvawth 83 28 COVID-19 COVID-19 NNP cord-266988-72uvawth 83 29 . . . cord-266988-72uvawth 84 1 The the DT cord-266988-72uvawth 84 2 trinity trinity NN cord-266988-72uvawth 84 3 of of IN cord-266988-72uvawth 84 4 COVID-19 COVID-19 NNP cord-266988-72uvawth 84 5 : : : cord-266988-72uvawth 84 6 immunity immunity NN cord-266988-72uvawth 84 7 , , , cord-266988-72uvawth 84 8 inflammation inflammation NN cord-266988-72uvawth 84 9 and and CC cord-266988-72uvawth 84 10 intervention intervention NN cord-266988-72uvawth 84 11 Epidemiology epidemiology NN cord-266988-72uvawth 84 12 and and CC cord-266988-72uvawth 84 13 transmission transmission NN cord-266988-72uvawth 84 14 of of IN cord-266988-72uvawth 84 15 COVID-19 covid-19 CD cord-266988-72uvawth 84 16 in in IN cord-266988-72uvawth 84 17 391 391 CD cord-266988-72uvawth 84 18 cases case NNS cord-266988-72uvawth 84 19 and and CC cord-266988-72uvawth 84 20 1286 1286 CD cord-266988-72uvawth 84 21 of of IN cord-266988-72uvawth 84 22 their -PRON- PRP$ cord-266988-72uvawth 84 23 close close JJ cord-266988-72uvawth 84 24 contacts contact NNS cord-266988-72uvawth 84 25 in in IN cord-266988-72uvawth 84 26 Shenzhen Shenzhen NNP cord-266988-72uvawth 84 27 , , , cord-266988-72uvawth 84 28 China China NNP cord-266988-72uvawth 84 29 : : : cord-266988-72uvawth 84 30 a a DT cord-266988-72uvawth 84 31 retrospective retrospective JJ cord-266988-72uvawth 84 32 cohort cohort NN cord-266988-72uvawth 84 33 study study NN cord-266988-72uvawth 84 34 COVID-19 COVID-19 NNP cord-266988-72uvawth 84 35 pathophysiology pathophysiology NN cord-266988-72uvawth 84 36 : : : cord-266988-72uvawth 84 37 a a DT cord-266988-72uvawth 84 38 review review NN cord-266988-72uvawth 85 1 Pulmonary pulmonary JJ cord-266988-72uvawth 85 2 vascular vascular JJ cord-266988-72uvawth 85 3 Endothelialitis Endothelialitis NNP cord-266988-72uvawth 85 4 , , , cord-266988-72uvawth 85 5 thrombosis thrombosis NN cord-266988-72uvawth 85 6 , , , cord-266988-72uvawth 85 7 and and CC cord-266988-72uvawth 85 8 angiogenesis angiogenesis NN cord-266988-72uvawth 85 9 in in IN cord-266988-72uvawth 85 10 Covid-19 covid-19 NN cord-266988-72uvawth 85 11 The the DT cord-266988-72uvawth 85 12 epidemiology epidemiology NN cord-266988-72uvawth 85 13 and and CC cord-266988-72uvawth 85 14 pathogenesis pathogenesis NN cord-266988-72uvawth 85 15 of of IN cord-266988-72uvawth 85 16 coronavirus coronavirus NN cord-266988-72uvawth 85 17 disease disease NN cord-266988-72uvawth 85 18 ( ( -LRB- cord-266988-72uvawth 85 19 COVID-19 COVID-19 NNP cord-266988-72uvawth 85 20 ) ) -RRB- cord-266988-72uvawth 85 21 outbreak outbreak NN cord-266988-72uvawth 86 1 A a DT cord-266988-72uvawth 86 2 review review NN cord-266988-72uvawth 86 3 on on IN cord-266988-72uvawth 86 4 SARS SARS NNP cord-266988-72uvawth 86 5 - - HYPH cord-266988-72uvawth 86 6 CoV-2 CoV-2 NNP cord-266988-72uvawth 86 7 virology virology NN cord-266988-72uvawth 86 8 , , , cord-266988-72uvawth 86 9 pathophysiology pathophysiology NN cord-266988-72uvawth 86 10 , , , cord-266988-72uvawth 86 11 animal animal NN cord-266988-72uvawth 86 12 models model NNS cord-266988-72uvawth 86 13 , , , cord-266988-72uvawth 86 14 and and CC cord-266988-72uvawth 86 15 anti anti JJ cord-266988-72uvawth 86 16 - - JJ cord-266988-72uvawth 86 17 viral viral JJ cord-266988-72uvawth 86 18 interventions intervention NNS cord-266988-72uvawth 86 19 Pathology pathology NN cord-266988-72uvawth 86 20 and and CC cord-266988-72uvawth 86 21 pathogenesis pathogenesis NN cord-266988-72uvawth 86 22 of of IN cord-266988-72uvawth 86 23 severe severe JJ cord-266988-72uvawth 86 24 acute acute JJ cord-266988-72uvawth 86 25 respiratory respiratory JJ cord-266988-72uvawth 86 26 syndrome syndrome NN cord-266988-72uvawth 86 27 Pulmonary pulmonary JJ cord-266988-72uvawth 86 28 pathology pathology NN cord-266988-72uvawth 86 29 of of IN cord-266988-72uvawth 86 30 early early JJ cord-266988-72uvawth 86 31 - - HYPH cord-266988-72uvawth 86 32 phase phase NN cord-266988-72uvawth 86 33 2019 2019 CD cord-266988-72uvawth 86 34 novel novel NN cord-266988-72uvawth 86 35 coronavirus coronavirus NN cord-266988-72uvawth 86 36 ( ( -LRB- cord-266988-72uvawth 86 37 COVID-19 COVID-19 NNP cord-266988-72uvawth 86 38 ) ) -RRB- cord-266988-72uvawth 86 39 pneumonia pneumonia NN cord-266988-72uvawth 86 40 in in IN cord-266988-72uvawth 86 41 two two CD cord-266988-72uvawth 86 42 patients patient NNS cord-266988-72uvawth 86 43 with with IN cord-266988-72uvawth 86 44 lung lung NN cord-266988-72uvawth 86 45 cancer cancer NN cord-266988-72uvawth 86 46 Immunohistochemical Immunohistochemical NNP cord-266988-72uvawth 86 47 , , , cord-266988-72uvawth 86 48 and and CC cord-266988-72uvawth 86 49 Ultrastructural Ultrastructural NNP cord-266988-72uvawth 86 50 findings finding NNS cord-266988-72uvawth 86 51 of of IN cord-266988-72uvawth 86 52 a a DT cord-266988-72uvawth 86 53 fatal fatal JJ cord-266988-72uvawth 86 54 case case NN cord-266988-72uvawth 86 55 of of IN cord-266988-72uvawth 86 56 Middle Middle NNP cord-266988-72uvawth 86 57 East East NNP cord-266988-72uvawth 86 58 respiratory respiratory JJ cord-266988-72uvawth 86 59 syndrome syndrome NN cord-266988-72uvawth 86 60 coronavirus coronavirus NN cord-266988-72uvawth 86 61 infection infection NN cord-266988-72uvawth 86 62 in in IN cord-266988-72uvawth 86 63 the the DT cord-266988-72uvawth 86 64 United United NNP cord-266988-72uvawth 86 65 Arab Arab NNP cord-266988-72uvawth 86 66 Emirates Emirates NNPS cord-266988-72uvawth 87 1 A a DT cord-266988-72uvawth 87 2 call call NN cord-266988-72uvawth 87 3 to to IN cord-266988-72uvawth 87 4 action action NN cord-266988-72uvawth 87 5 : : : cord-266988-72uvawth 87 6 the the DT cord-266988-72uvawth 87 7 need need NN cord-266988-72uvawth 87 8 for for IN cord-266988-72uvawth 87 9 autopsies autopsy NNS cord-266988-72uvawth 87 10 to to TO cord-266988-72uvawth 87 11 determine determine VB cord-266988-72uvawth 87 12 the the DT cord-266988-72uvawth 87 13 full full JJ cord-266988-72uvawth 87 14 extent extent NN cord-266988-72uvawth 87 15 of of IN cord-266988-72uvawth 87 16 organ organ NN cord-266988-72uvawth 87 17 involvement involvement NN cord-266988-72uvawth 87 18 associated associate VBN cord-266988-72uvawth 87 19 with with IN cord-266988-72uvawth 87 20 COVID-19 COVID-19 NNP cord-266988-72uvawth 87 21 No no DT cord-266988-72uvawth 87 22 autopsies autopsy NNS cord-266988-72uvawth 87 23 on on IN cord-266988-72uvawth 87 24 COVID-19 covid-19 JJ cord-266988-72uvawth 87 25 deaths death NNS cord-266988-72uvawth 87 26 : : : cord-266988-72uvawth 87 27 a a DT cord-266988-72uvawth 87 28 missed miss VBN cord-266988-72uvawth 87 29 opportunity opportunity NN cord-266988-72uvawth 87 30 and and CC cord-266988-72uvawth 87 31 the the DT cord-266988-72uvawth 87 32 lockdown lockdown NN cord-266988-72uvawth 87 33 of of IN cord-266988-72uvawth 87 34 science science NN cord-266988-72uvawth 87 35 Pathophysiology Pathophysiology NNP cord-266988-72uvawth 87 36 of of IN cord-266988-72uvawth 87 37 SARS SARS NNP cord-266988-72uvawth 88 1 -Cov-2 -Cov-2 : cord-266988-72uvawth 88 2 : : : cord-266988-72uvawth 88 3 targeting targeting NN cord-266988-72uvawth 88 4 of of IN cord-266988-72uvawth 88 5 endothelial endothelial JJ cord-266988-72uvawth 88 6 cells cell NNS cord-266988-72uvawth 88 7 renders render VBZ cord-266988-72uvawth 88 8 a a DT cord-266988-72uvawth 88 9 complex complex JJ cord-266988-72uvawth 88 10 disease disease NN cord-266988-72uvawth 88 11 with with IN cord-266988-72uvawth 88 12 thrombotic thrombotic JJ cord-266988-72uvawth 88 13 microangiopathy microangiopathy NNP cord-266988-72uvawth 88 14 and and CC cord-266988-72uvawth 88 15 aberrant aberrant JJ cord-266988-72uvawth 88 16 immune immune JJ cord-266988-72uvawth 88 17 response response NN cord-266988-72uvawth 88 18 . . . cord-266988-72uvawth 89 1 The the DT cord-266988-72uvawth 89 2 Mount Mount NNP cord-266988-72uvawth 89 3 Sinai Sinai NNP cord-266988-72uvawth 89 4 COVID-19 COVID-19 NNP cord-266988-72uvawth 89 5 autopsy autopsy JJ cord-266988-72uvawth 89 6 experience experience NN cord-266988-72uvawth 90 1 The the DT cord-266988-72uvawth 90 2 emerging emerge VBG cord-266988-72uvawth 90 3 spectrum spectrum NN cord-266988-72uvawth 90 4 of of IN cord-266988-72uvawth 90 5 cardiopulmonary cardiopulmonary JJ cord-266988-72uvawth 90 6 pathology pathology NN cord-266988-72uvawth 90 7 of of IN cord-266988-72uvawth 90 8 the the DT cord-266988-72uvawth 90 9 coronavirus coronavirus NN cord-266988-72uvawth 90 10 disease disease NN cord-266988-72uvawth 90 11 2019 2019 CD cord-266988-72uvawth 90 12 ( ( -LRB- cord-266988-72uvawth 90 13 COVID-19 COVID-19 NNP cord-266988-72uvawth 90 14 ) ) -RRB- cord-266988-72uvawth 91 1 : : : cord-266988-72uvawth 91 2 report report VB cord-266988-72uvawth 91 3 of of IN cord-266988-72uvawth 91 4 3 3 CD cord-266988-72uvawth 91 5 autopsies autopsy NNS cord-266988-72uvawth 91 6 from from IN cord-266988-72uvawth 91 7 Houston Houston NNP cord-266988-72uvawth 91 8 , , , cord-266988-72uvawth 91 9 Texas Texas NNP cord-266988-72uvawth 91 10 , , , cord-266988-72uvawth 91 11 and and CC cord-266988-72uvawth 91 12 review review NN cord-266988-72uvawth 91 13 of of IN cord-266988-72uvawth 91 14 autopsy autopsy JJ cord-266988-72uvawth 91 15 findings finding NNS cord-266988-72uvawth 91 16 from from IN cord-266988-72uvawth 91 17 other other JJ cord-266988-72uvawth 91 18 United United NNP cord-266988-72uvawth 91 19 States States NNP cord-266988-72uvawth 91 20 cities city NNS cord-266988-72uvawth 91 21 Pulmonary pulmonary JJ cord-266988-72uvawth 91 22 post post JJ cord-266988-72uvawth 91 23 - - JJ cord-266988-72uvawth 91 24 mortem mortem JJ cord-266988-72uvawth 91 25 findings finding NNS cord-266988-72uvawth 91 26 in in IN cord-266988-72uvawth 91 27 a a DT cord-266988-72uvawth 91 28 series series NN cord-266988-72uvawth 91 29 of of IN cord-266988-72uvawth 91 30 COVID-19 covid-19 JJ cord-266988-72uvawth 91 31 cases case NNS cord-266988-72uvawth 91 32 from from IN cord-266988-72uvawth 91 33 northern northern JJ cord-266988-72uvawth 91 34 Italy Italy NNP cord-266988-72uvawth 91 35 : : : cord-266988-72uvawth 91 36 a a DT cord-266988-72uvawth 91 37 two two CD cord-266988-72uvawth 91 38 - - HYPH cord-266988-72uvawth 91 39 Centre centre NN cord-266988-72uvawth 91 40 descriptive descriptive JJ cord-266988-72uvawth 91 41 study study NN cord-266988-72uvawth 91 42 Time time NN cord-266988-72uvawth 91 43 to to TO cord-266988-72uvawth 91 44 consider consider VB cord-266988-72uvawth 91 45 histologic histologic JJ cord-266988-72uvawth 91 46 pattern pattern NN cord-266988-72uvawth 91 47 of of IN cord-266988-72uvawth 91 48 lung lung NN cord-266988-72uvawth 91 49 injury injury NN cord-266988-72uvawth 91 50 to to TO cord-266988-72uvawth 91 51 treat treat VB cord-266988-72uvawth 91 52 critically critically RB cord-266988-72uvawth 91 53 ill ill JJ cord-266988-72uvawth 91 54 patients patient NNS cord-266988-72uvawth 91 55 with with IN cord-266988-72uvawth 91 56 COVID-19 covid-19 JJ cord-266988-72uvawth 91 57 infection infection NN cord-266988-72uvawth 91 58 Pulmonary pulmonary JJ cord-266988-72uvawth 91 59 and and CC cord-266988-72uvawth 91 60 cardiac cardiac JJ cord-266988-72uvawth 91 61 pathology pathology NN cord-266988-72uvawth 91 62 in in IN cord-266988-72uvawth 91 63 African african JJ cord-266988-72uvawth 91 64 American american JJ cord-266988-72uvawth 91 65 patients patient NNS cord-266988-72uvawth 91 66 with with IN cord-266988-72uvawth 91 67 COVID-19 COVID-19 NNP cord-266988-72uvawth 91 68 : : : cord-266988-72uvawth 91 69 an an DT cord-266988-72uvawth 91 70 autopsy autopsy JJ cord-266988-72uvawth 91 71 series series NN cord-266988-72uvawth 91 72 from from IN cord-266988-72uvawth 91 73 New New NNP cord-266988-72uvawth 91 74 Orleans Orleans NNP cord-266988-72uvawth 91 75 Pulmonary Pulmonary NNP cord-266988-72uvawth 91 76 arterial arterial JJ cord-266988-72uvawth 91 77 thrombosis thrombosis NN cord-266988-72uvawth 91 78 in in IN cord-266988-72uvawth 91 79 COVID-19 COVID-19 NNP cord-266988-72uvawth 91 80 with with IN cord-266988-72uvawth 91 81 fatal fatal JJ cord-266988-72uvawth 91 82 outcome outcome NN cord-266988-72uvawth 91 83 : : : cord-266988-72uvawth 91 84 results result NNS cord-266988-72uvawth 91 85 from from IN cord-266988-72uvawth 91 86 a a DT cord-266988-72uvawth 91 87 prospective prospective JJ cord-266988-72uvawth 91 88 , , , cord-266988-72uvawth 91 89 Single Single NNP cord-266988-72uvawth 91 90 - - HYPH cord-266988-72uvawth 91 91 Center Center NNP cord-266988-72uvawth 91 92 Complement Complement NNP cord-266988-72uvawth 91 93 associated associate VBD cord-266988-72uvawth 91 94 microvascular microvascular JJ cord-266988-72uvawth 91 95 injury injury NN cord-266988-72uvawth 91 96 and and CC cord-266988-72uvawth 91 97 thrombosis thrombosis NN cord-266988-72uvawth 91 98 in in IN cord-266988-72uvawth 91 99 the the DT cord-266988-72uvawth 91 100 pathogenesis pathogenesis NN cord-266988-72uvawth 91 101 of of IN cord-266988-72uvawth 91 102 severe severe JJ cord-266988-72uvawth 91 103 COVID-19 covid-19 JJ cord-266988-72uvawth 91 104 infection infection NN cord-266988-72uvawth 91 105 : : : cord-266988-72uvawth 91 106 a a DT cord-266988-72uvawth 91 107 report report NN cord-266988-72uvawth 91 108 of of IN cord-266988-72uvawth 91 109 five five CD cord-266988-72uvawth 91 110 cases case NNS cord-266988-72uvawth 91 111 Post post VB cord-266988-72uvawth 91 112 - - JJ cord-266988-72uvawth 91 113 mortem mortem JJ cord-266988-72uvawth 91 114 examination examination NN cord-266988-72uvawth 91 115 of of IN cord-266988-72uvawth 91 116 COVID19 covid19 NN cord-266988-72uvawth 91 117 patients patient NNS cord-266988-72uvawth 91 118 reveals reveal VBZ cord-266988-72uvawth 91 119 diffuse diffuse JJ cord-266988-72uvawth 91 120 alveolar alveolar NN cord-266988-72uvawth 91 121 damage damage NN cord-266988-72uvawth 91 122 with with IN cord-266988-72uvawth 91 123 severe severe JJ cord-266988-72uvawth 91 124 capillary capillary JJ cord-266988-72uvawth 91 125 congestion congestion NN cord-266988-72uvawth 91 126 and and CC cord-266988-72uvawth 91 127 variegated variegated JJ cord-266988-72uvawth 91 128 findings finding NNS cord-266988-72uvawth 91 129 of of IN cord-266988-72uvawth 91 130 lungs lung NNS cord-266988-72uvawth 91 131 and and CC cord-266988-72uvawth 91 132 other other JJ cord-266988-72uvawth 91 133 organs organ NNS cord-266988-72uvawth 91 134 suggesting suggest VBG cord-266988-72uvawth 91 135 vascular vascular JJ cord-266988-72uvawth 91 136 dysfunction dysfunction NN cord-266988-72uvawth 91 137 Multiorgan Multiorgan NNP cord-266988-72uvawth 91 138 and and CC cord-266988-72uvawth 91 139 renal renal JJ cord-266988-72uvawth 91 140 tropism tropism NN cord-266988-72uvawth 91 141 of of IN cord-266988-72uvawth 91 142 SARS SARS NNP cord-266988-72uvawth 91 143 - - HYPH cord-266988-72uvawth 91 144 CoV-2 CoV-2 NNP cord-266988-72uvawth 91 145 Postmortem Postmortem NNP cord-266988-72uvawth 91 146 examination examination NN cord-266988-72uvawth 91 147 of of IN cord-266988-72uvawth 91 148 patients patient NNS cord-266988-72uvawth 91 149 with with IN cord-266988-72uvawth 91 150 COVID-19 COVID-19 NNP cord-266988-72uvawth 91 151 Autopsy autopsy JJ cord-266988-72uvawth 91 152 findings finding NNS cord-266988-72uvawth 91 153 and and CC cord-266988-72uvawth 91 154 venous venous JJ cord-266988-72uvawth 91 155 thromboembolism thromboembolism NN cord-266988-72uvawth 91 156 in in IN cord-266988-72uvawth 91 157 patients patient NNS cord-266988-72uvawth 91 158 with with IN cord-266988-72uvawth 91 159 COVID-19 COVID-19 NNP cord-266988-72uvawth 91 160 The the DT cord-266988-72uvawth 91 161 autopsy autopsy JJ cord-266988-72uvawth 91 162 report report NN cord-266988-72uvawth 91 163 of of IN cord-266988-72uvawth 91 164 the the DT cord-266988-72uvawth 91 165 demise demise NN cord-266988-72uvawth 91 166 of of IN cord-266988-72uvawth 91 167 patient patient NN cord-266988-72uvawth 91 168 of of IN cord-266988-72uvawth 91 169 2019 2019 CD cord-266988-72uvawth 91 170 novel novel JJ cord-266988-72uvawth 91 171 corona corona NN cord-266988-72uvawth 91 172 virus virus NN cord-266988-72uvawth 91 173 Full full JJ cord-266988-72uvawth 91 174 spectrum spectrum NN cord-266988-72uvawth 91 175 of of IN cord-266988-72uvawth 91 176 COVID-19 covid-19 JJ cord-266988-72uvawth 91 177 severity severity NN cord-266988-72uvawth 91 178 still still RB cord-266988-72uvawth 91 179 being be VBG cord-266988-72uvawth 91 180 depicted depict VBN cord-266988-72uvawth 91 181 Pathological pathological JJ cord-266988-72uvawth 91 182 findings finding NNS cord-266988-72uvawth 91 183 of of IN cord-266988-72uvawth 91 184 COVID-19 COVID-19 NNP cord-266988-72uvawth 91 185 associated associate VBN cord-266988-72uvawth 91 186 with with IN cord-266988-72uvawth 91 187 acute acute JJ cord-266988-72uvawth 91 188 respiratory respiratory JJ cord-266988-72uvawth 91 189 distress distress NN cord-266988-72uvawth 91 190 syndrome syndrome NN cord-266988-72uvawth 92 1 The the DT cord-266988-72uvawth 92 2 importance importance NN cord-266988-72uvawth 92 3 of of IN cord-266988-72uvawth 92 4 the the DT cord-266988-72uvawth 92 5 autopsy autopsy JJ cord-266988-72uvawth 92 6 in in IN cord-266988-72uvawth 92 7 medicine medicine NN cord-266988-72uvawth 92 8 : : : cord-266988-72uvawth 92 9 perspectives perspective NNS cord-266988-72uvawth 92 10 of of IN cord-266988-72uvawth 93 1 pathology pathology NN cord-266988-72uvawth 93 2 colleagues colleague NNS cord-266988-72uvawth 93 3 Severe severe JJ cord-266988-72uvawth 93 4 acute acute JJ cord-266988-72uvawth 93 5 Perpiratory Perpiratory NNP cord-266988-72uvawth 93 6 syndrome syndrome NN cord-266988-72uvawth 93 7 Coronavirus-2 Coronavirus-2 NNP cord-266988-72uvawth 94 1 ( ( -LRB- cord-266988-72uvawth 94 2 SaRS SaRS NNP cord-266988-72uvawth 94 3 - - HYPH cord-266988-72uvawth 94 4 Cov-2 Cov-2 NNP cord-266988-72uvawth 94 5 ) ) -RRB- cord-266988-72uvawth 94 6 and and CC cord-266988-72uvawth 94 7 coronavirus coronavirus NN cord-266988-72uvawth 94 8 disease disease NN cord-266988-72uvawth 94 9 19 19 CD cord-266988-72uvawth 94 10 ( ( -LRB- cord-266988-72uvawth 94 11 COVID-19)-anatomic covid-19)-anatomic NN cord-266988-72uvawth 94 12 pathology pathology NN cord-266988-72uvawth 94 13 perspective perspective NN cord-266988-72uvawth 94 14 on on IN cord-266988-72uvawth 94 15 current current JJ cord-266988-72uvawth 94 16 knowledge knowledge NN cord-266988-72uvawth 94 17 Immune immune NN cord-266988-72uvawth 94 18 mechanisms mechanism NNS cord-266988-72uvawth 94 19 of of IN cord-266988-72uvawth 94 20 pulmonary pulmonary JJ cord-266988-72uvawth 94 21 intravascular intravascular JJ cord-266988-72uvawth 94 22 coagulopathy coagulopathy NN cord-266988-72uvawth 94 23 in in IN cord-266988-72uvawth 94 24 COVID-19 COVID-19 NNP cord-266988-72uvawth 94 25 pneumonia pneumonia NN cord-266988-72uvawth 95 1 The the DT cord-266988-72uvawth 95 2 role role NN cord-266988-72uvawth 95 3 of of IN cord-266988-72uvawth 95 4 cytokines cytokine NNS cord-266988-72uvawth 95 5 including include VBG cord-266988-72uvawth 95 6 Interleukin-6 Interleukin-6 NNP cord-266988-72uvawth 95 7 in in IN cord-266988-72uvawth 95 8 COVID-19 COVID-19 NNP cord-266988-72uvawth 95 9 induced induce VBN cord-266988-72uvawth 95 10 pneumonia pneumonia NN cord-266988-72uvawth 95 11 and and CC cord-266988-72uvawth 95 12 macrophage macrophage NN cord-266988-72uvawth 95 13 activation activation NN cord-266988-72uvawth 95 14 syndrome syndrome NN cord-266988-72uvawth 95 15 - - HYPH cord-266988-72uvawth 95 16 like like JJ cord-266988-72uvawth 95 17 disease disease NN cord-266988-72uvawth 96 1 COVID-19 covid-19 JJ cord-266988-72uvawth 96 2 and and CC cord-266988-72uvawth 96 3 thrombotic thrombotic JJ cord-266988-72uvawth 96 4 or or CC cord-266988-72uvawth 96 5 thromboembolic thromboembolic JJ cord-266988-72uvawth 96 6 disease disease NN cord-266988-72uvawth 96 7 : : : cord-266988-72uvawth 96 8 implications implication NNS cord-266988-72uvawth 96 9 for for IN cord-266988-72uvawth 96 10 prevention prevention NN cord-266988-72uvawth 96 11 , , , cord-266988-72uvawth 96 12 antithrombotic antithrombotic JJ cord-266988-72uvawth 96 13 therapy therapy NN cord-266988-72uvawth 96 14 , , , cord-266988-72uvawth 96 15 and and CC cord-266988-72uvawth 96 16 follow follow NN cord-266988-72uvawth 96 17 - - HYPH cord-266988-72uvawth 96 18 up up NN cord-266988-72uvawth 96 19 : : : cord-266988-72uvawth 96 20 JACC JACC NNP cord-266988-72uvawth 96 21 state state NN cord-266988-72uvawth 96 22 - - HYPH cord-266988-72uvawth 96 23 of of IN cord-266988-72uvawth 96 24 - - HYPH cord-266988-72uvawth 96 25 the the DT cord-266988-72uvawth 96 26 - - HYPH cord-266988-72uvawth 96 27 art art NN cord-266988-72uvawth 96 28 review review NN cord-266988-72uvawth 97 1 Covid-19 Covid-19 NNP cord-266988-72uvawth 97 2 : : : cord-266988-72uvawth 97 3 low low JJ cord-266988-72uvawth 97 4 dose dose NN cord-266988-72uvawth 97 5 steroid steroid NN cord-266988-72uvawth 97 6 cuts cut NNS cord-266988-72uvawth 97 7 death death NN cord-266988-72uvawth 97 8 in in IN cord-266988-72uvawth 97 9 ventilated ventilate VBN cord-266988-72uvawth 97 10 patients patient NNS cord-266988-72uvawth 97 11 by by IN cord-266988-72uvawth 97 12 one one CD cord-266988-72uvawth 97 13 third third JJ cord-266988-72uvawth 97 14 , , , cord-266988-72uvawth 97 15 trial trial NN cord-266988-72uvawth 97 16 finds find VBZ cord-266988-72uvawth 97 17 Magnetic magnetic JJ cord-266988-72uvawth 97 18 resonance resonance NN cord-266988-72uvawth 97 19 imaging imaging NN cord-266988-72uvawth 97 20 alteration alteration NN cord-266988-72uvawth 97 21 of of IN cord-266988-72uvawth 97 22 the the DT cord-266988-72uvawth 97 23 brain brain NN cord-266988-72uvawth 97 24 in in IN cord-266988-72uvawth 97 25 a a DT cord-266988-72uvawth 97 26 patient patient NN cord-266988-72uvawth 97 27 with with IN cord-266988-72uvawth 97 28 coronavirus coronavirus NN cord-266988-72uvawth 97 29 disease disease NN cord-266988-72uvawth 97 30 2019 2019 CD cord-266988-72uvawth 97 31 ( ( -LRB- cord-266988-72uvawth 97 32 COVID-19 COVID-19 NNP cord-266988-72uvawth 97 33 ) ) -RRB- cord-266988-72uvawth 97 34 and and CC cord-266988-72uvawth 97 35 anosmia anosmia NN cord-266988-72uvawth 97 36 Severe severe JJ cord-266988-72uvawth 97 37 acute acute JJ cord-266988-72uvawth 97 38 respiratory respiratory JJ cord-266988-72uvawth 97 39 syndrome syndrome NN cord-266988-72uvawth 97 40 coronavirus coronavirus NN cord-266988-72uvawth 97 41 infection infection NN cord-266988-72uvawth 97 42 causes cause VBZ cord-266988-72uvawth 97 43 neuronal neuronal JJ cord-266988-72uvawth 97 44 death death NN cord-266988-72uvawth 97 45 in in IN cord-266988-72uvawth 97 46 the the DT cord-266988-72uvawth 97 47 absence absence NN cord-266988-72uvawth 97 48 of of IN cord-266988-72uvawth 97 49 encephalitis encephalitis NN cord-266988-72uvawth 97 50 in in IN cord-266988-72uvawth 97 51 mice mouse NNS cord-266988-72uvawth 97 52 transgenic transgenic JJ cord-266988-72uvawth 97 53 for for IN cord-266988-72uvawth 97 54 human human JJ cord-266988-72uvawth 97 55 ACE2 ACE2 NNP cord-266988-72uvawth 97 56 Neuropathological Neuropathological NNP cord-266988-72uvawth 97 57 features feature NNS cord-266988-72uvawth 97 58 of of IN cord-266988-72uvawth 97 59 Covid-19 Covid-19 NNP cord-266988-72uvawth 97 60 COVID-19 COVID-19 NNP cord-266988-72uvawth 97 61 vaccine vaccine NN cord-266988-72uvawth 97 62 development development NN cord-266988-72uvawth 97 63 pipeline pipeline NN cord-266988-72uvawth 97 64 gears gear VBZ cord-266988-72uvawth 97 65 up up RP cord-266988-72uvawth 97 66 COVID-19 COVID-19 NNP cord-266988-72uvawth 97 67 pandemic pandemic NN cord-266988-72uvawth 97 68 : : : cord-266988-72uvawth 98 1 an an DT cord-266988-72uvawth 98 2 overview overview NN cord-266988-72uvawth 98 3 of of IN cord-266988-72uvawth 98 4 epidemiology epidemiology NN cord-266988-72uvawth 98 5 , , , cord-266988-72uvawth 98 6 pathogenesis pathogenesis NN cord-266988-72uvawth 98 7 , , , cord-266988-72uvawth 98 8 diagnostics diagnostic NNS cord-266988-72uvawth 98 9 and and CC cord-266988-72uvawth 98 10 potential potential JJ cord-266988-72uvawth 98 11 vaccines vaccine NNS cord-266988-72uvawth 98 12 and and CC cord-266988-72uvawth 98 13 therapeutics therapeutic NNS cord-266988-72uvawth 98 14 Publisher Publisher NNP cord-266988-72uvawth 98 15 's 's POS cord-266988-72uvawth 98 16 Note Note NNP cord-266988-72uvawth 98 17 Springer Springer NNP cord-266988-72uvawth 98 18 Nature Nature NNP cord-266988-72uvawth 98 19 remains remain VBZ cord-266988-72uvawth 98 20 neutral neutral JJ cord-266988-72uvawth 98 21 with with IN cord-266988-72uvawth 98 22 regard regard NN cord-266988-72uvawth 98 23 to to IN cord-266988-72uvawth 98 24 jurisdictional jurisdictional JJ cord-266988-72uvawth 98 25 claims claim NNS cord-266988-72uvawth 98 26 in in IN cord-266988-72uvawth 98 27 published publish VBN cord-266988-72uvawth 98 28 maps map NNS cord-266988-72uvawth 98 29 and and CC cord-266988-72uvawth 98 30 institutional institutional JJ cord-266988-72uvawth 98 31 affiliations affiliation NNS cord-266988-72uvawth 99 1 Acknowledgements acknowledgement NNS cord-266988-72uvawth 100 1 I -PRON- PRP cord-266988-72uvawth 100 2 would would MD cord-266988-72uvawth 100 3 like like VB cord-266988-72uvawth 100 4 to to TO cord-266988-72uvawth 100 5 acknowledge acknowledge VB cord-266988-72uvawth 100 6 the the DT cord-266988-72uvawth 100 7 expertise expertise NN cord-266988-72uvawth 100 8 and and CC cord-266988-72uvawth 100 9 knowledge knowledge NN cord-266988-72uvawth 100 10 of of IN cord-266988-72uvawth 100 11 our -PRON- PRP$ cord-266988-72uvawth 100 12 guest guest NN cord-266988-72uvawth 100 13 authors author NNS cord-266988-72uvawth 100 14 ( ( -LRB- cord-266988-72uvawth 100 15 Rolf Rolf NNP cord-266988-72uvawth 100 16 F. F. NNP cord-266988-72uvawth 100 17 Barth Barth NNP cord-266988-72uvawth 100 18 and and CC cord-266988-72uvawth 100 19 L. L. NNP cord-266988-72uvawth 100 20 Maximillian Maximillian NNP cord-266988-72uvawth 100 21 Buja Buja NNP cord-266988-72uvawth 100 22 for for IN cord-266988-72uvawth 100 23 this this DT cord-266988-72uvawth 100 24 editorial editorial NN cord-266988-72uvawth 100 25 . . . cord-266988-72uvawth 101 1 The the DT cord-266988-72uvawth 101 2 author(s author(s NNP cord-266988-72uvawth 101 3 ) ) -RRB- cord-266988-72uvawth 101 4 read read VBD cord-266988-72uvawth 101 5 and and CC cord-266988-72uvawth 101 6 approved approve VBD cord-266988-72uvawth 101 7 the the DT cord-266988-72uvawth 101 8 final final JJ cord-266988-72uvawth 101 9 manuscript manuscript NN cord-266988-72uvawth 101 10 . . . cord-266988-72uvawth 102 1 All all DT cord-266988-72uvawth 102 2 authors author NNS cord-266988-72uvawth 102 3 contributed contribute VBD cord-266988-72uvawth 102 4 in in IN cord-266988-72uvawth 102 5 preparing prepare VBG cord-266988-72uvawth 102 6 and and CC cord-266988-72uvawth 102 7 review review NN cord-266988-72uvawth 102 8 of of IN cord-266988-72uvawth 102 9 the the DT cord-266988-72uvawth 102 10 entire entire JJ cord-266988-72uvawth 102 11 manuscript manuscript NN cord-266988-72uvawth 102 12 . . . cord-266988-72uvawth 103 1 The the DT cord-266988-72uvawth 103 2 authors author NNS cord-266988-72uvawth 103 3 declare declare VBP cord-266988-72uvawth 103 4 that that IN cord-266988-72uvawth 103 5 they -PRON- PRP cord-266988-72uvawth 103 6 have have VBP cord-266988-72uvawth 103 7 no no DT cord-266988-72uvawth 103 8 competing compete VBG cord-266988-72uvawth 103 9 interests interest NNS cord-266988-72uvawth 103 10 . . . cord-266988-72uvawth 103 11 _SP