id	sid	tid	token	lemma	pos
cord-296585-yfh5d4io	1	1	key	key	JJ
cord-296585-yfh5d4io	1	2	:	:	:
cord-296585-yfh5d4io	1	3	cord-296585-yfh5d4io	cord-296585-yfh5d4io	CD
cord-296585-yfh5d4io	1	4	authors	author	NNS
cord-296585-yfh5d4io	1	5	:	:	:
cord-296585-yfh5d4io	2	1	Su	Su	NNP
cord-296585-yfh5d4io	2	2	,	,	,
cord-296585-yfh5d4io	2	3	Yu	Yu	NNP
cord-296585-yfh5d4io	2	4	-	-	HYPH
cord-296585-yfh5d4io	2	5	Ching	Ching	NNP
cord-296585-yfh5d4io	2	6	;	;	:
cord-296585-yfh5d4io	2	7	Jalalvand	Jalalvand	NNP
cord-296585-yfh5d4io	2	8	,	,	,
cord-296585-yfh5d4io	2	9	Farshid	Farshid	NNP
cord-296585-yfh5d4io	2	10	;	;	:
cord-296585-yfh5d4io	2	11	Thegerström	Thegerström	NNP
cord-296585-yfh5d4io	2	12	,	,	,
cord-296585-yfh5d4io	2	13	John	John	NNP
cord-296585-yfh5d4io	2	14	;	;	:
cord-296585-yfh5d4io	2	15	Riesbeck	Riesbeck	NNP
cord-296585-yfh5d4io	2	16	,	,	,
cord-296585-yfh5d4io	2	17	Kristian	Kristian	NNP
cord-296585-yfh5d4io	2	18	title	title	NN
cord-296585-yfh5d4io	2	19	:	:	:
cord-296585-yfh5d4io	2	20	The	the	DT
cord-296585-yfh5d4io	2	21	Interplay	Interplay	NNP
cord-296585-yfh5d4io	2	22	Between	between	IN
cord-296585-yfh5d4io	2	23	Immune	Immune	NNP
cord-296585-yfh5d4io	2	24	Response	response	NN
cord-296585-yfh5d4io	2	25	and	and	CC
cord-296585-yfh5d4io	2	26	Bacterial	bacterial	JJ
cord-296585-yfh5d4io	2	27	Infection	infection	NN
cord-296585-yfh5d4io	2	28	in	in	IN
cord-296585-yfh5d4io	2	29	COPD	COPD	NNP
cord-296585-yfh5d4io	2	30	:	:	:
cord-296585-yfh5d4io	2	31	Focus	Focus	NNP
cord-296585-yfh5d4io	2	32	Upon	upon	IN
cord-296585-yfh5d4io	2	33	Non	non	JJ
cord-296585-yfh5d4io	2	34	-	-	JJ
cord-296585-yfh5d4io	2	35	typeable	typeable	JJ
cord-296585-yfh5d4io	2	36	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	2	37	influenzae	influenzae	NN
cord-296585-yfh5d4io	2	38	date	date	NN
cord-296585-yfh5d4io	2	39	:	:	:
cord-296585-yfh5d4io	2	40	2018	2018	CD
cord-296585-yfh5d4io	2	41	-	-	HYPH
cord-296585-yfh5d4io	2	42	11	11	CD
cord-296585-yfh5d4io	2	43	-	-	HYPH
cord-296585-yfh5d4io	2	44	05	05	CD
cord-296585-yfh5d4io	2	45	journal	journal	NN
cord-296585-yfh5d4io	2	46	:	:	:
cord-296585-yfh5d4io	3	1	Front	Front	NNP
cord-296585-yfh5d4io	3	2	Immunol	Immunol	NNP
cord-296585-yfh5d4io	3	3	DOI	doi	NN
cord-296585-yfh5d4io	3	4	:	:	:
cord-296585-yfh5d4io	4	1	10.3389/	10.3389/	CD
cord-296585-yfh5d4io	5	1	fimmu.2018.02530	fimmu.2018.02530	CD
cord-296585-yfh5d4io	5	2	sha	sha	NNP
cord-296585-yfh5d4io	5	3	:	:	:
cord-296585-yfh5d4io	5	4	1d2a06d34c1ae369008931acca5000233e246011	1d2a06d34c1ae369008931acca5000233e246011	NNP
cord-296585-yfh5d4io	5	5	doc_id	doc_id	NNPS
cord-296585-yfh5d4io	5	6	:	:	:
cord-296585-yfh5d4io	5	7	296585	296585	CD
cord-296585-yfh5d4io	5	8	cord_uid	cord_uid	NNS
cord-296585-yfh5d4io	5	9	:	:	:
cord-296585-yfh5d4io	5	10	yfh5d4io	yfh5d4io	NNP
cord-296585-yfh5d4io	5	11	Chronic	Chronic	NNP
cord-296585-yfh5d4io	5	12	obstructive	obstructive	JJ
cord-296585-yfh5d4io	5	13	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	5	14	disease	disease	NN
cord-296585-yfh5d4io	5	15	(	(	-LRB-
cord-296585-yfh5d4io	5	16	COPD	COPD	NNP
cord-296585-yfh5d4io	5	17	)	)	-RRB-
cord-296585-yfh5d4io	5	18	is	be	VBZ
cord-296585-yfh5d4io	5	19	a	a	DT
cord-296585-yfh5d4io	5	20	debilitating	debilitating	JJ
cord-296585-yfh5d4io	5	21	respiratory	respiratory	JJ
cord-296585-yfh5d4io	5	22	disease	disease	NN
cord-296585-yfh5d4io	5	23	and	and	CC
cord-296585-yfh5d4io	5	24	one	one	CD
cord-296585-yfh5d4io	5	25	of	of	IN
cord-296585-yfh5d4io	5	26	the	the	DT
cord-296585-yfh5d4io	5	27	leading	lead	VBG
cord-296585-yfh5d4io	5	28	causes	cause	NNS
cord-296585-yfh5d4io	5	29	of	of	IN
cord-296585-yfh5d4io	5	30	morbidity	morbidity	NN
cord-296585-yfh5d4io	5	31	and	and	CC
cord-296585-yfh5d4io	5	32	mortality	mortality	NN
cord-296585-yfh5d4io	5	33	worldwide	worldwide	RB
cord-296585-yfh5d4io	5	34	.	.	.
cord-296585-yfh5d4io	6	1	It	-PRON-	PRP
cord-296585-yfh5d4io	6	2	is	be	VBZ
cord-296585-yfh5d4io	6	3	characterized	characterize	VBN
cord-296585-yfh5d4io	6	4	by	by	IN
cord-296585-yfh5d4io	6	5	persistent	persistent	JJ
cord-296585-yfh5d4io	6	6	respiratory	respiratory	JJ
cord-296585-yfh5d4io	6	7	symptoms	symptom	NNS
cord-296585-yfh5d4io	6	8	and	and	CC
cord-296585-yfh5d4io	6	9	airflow	airflow	NN
cord-296585-yfh5d4io	6	10	limitation	limitation	NN
cord-296585-yfh5d4io	6	11	due	due	IN
cord-296585-yfh5d4io	6	12	to	to	IN
cord-296585-yfh5d4io	6	13	abnormalities	abnormality	NNS
cord-296585-yfh5d4io	6	14	in	in	IN
cord-296585-yfh5d4io	6	15	the	the	DT
cord-296585-yfh5d4io	6	16	lower	low	JJR
cord-296585-yfh5d4io	6	17	airway	airway	NN
cord-296585-yfh5d4io	6	18	following	follow	VBG
cord-296585-yfh5d4io	6	19	consistent	consistent	JJ
cord-296585-yfh5d4io	6	20	exposure	exposure	NN
cord-296585-yfh5d4io	6	21	to	to	IN
cord-296585-yfh5d4io	6	22	noxious	noxious	JJ
cord-296585-yfh5d4io	6	23	particles	particle	NNS
cord-296585-yfh5d4io	6	24	or	or	CC
cord-296585-yfh5d4io	6	25	gases	gas	NNS
cord-296585-yfh5d4io	6	26	.	.	.
cord-296585-yfh5d4io	7	1	Acute	acute	JJ
cord-296585-yfh5d4io	7	2	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	7	3	of	of	IN
cord-296585-yfh5d4io	7	4	COPD	COPD	NNP
cord-296585-yfh5d4io	7	5	(	(	-LRB-
cord-296585-yfh5d4io	7	6	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	7	7	)	)	-RRB-
cord-296585-yfh5d4io	7	8	are	be	VBP
cord-296585-yfh5d4io	7	9	characterized	characterize	VBN
cord-296585-yfh5d4io	7	10	by	by	IN
cord-296585-yfh5d4io	7	11	increased	increase	VBN
cord-296585-yfh5d4io	7	12	cough	cough	NN
cord-296585-yfh5d4io	7	13	,	,	,
cord-296585-yfh5d4io	7	14	purulent	purulent	JJ
cord-296585-yfh5d4io	7	15	sputum	sputum	NN
cord-296585-yfh5d4io	7	16	production	production	NN
cord-296585-yfh5d4io	7	17	,	,	,
cord-296585-yfh5d4io	7	18	and	and	CC
cord-296585-yfh5d4io	7	19	dyspnea	dyspnea	NN
cord-296585-yfh5d4io	7	20	.	.	.
cord-296585-yfh5d4io	8	1	The	the	DT
cord-296585-yfh5d4io	8	2	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	8	3	is	be	VBZ
cord-296585-yfh5d4io	8	4	mostly	mostly	RB
cord-296585-yfh5d4io	8	5	associated	associate	VBN
cord-296585-yfh5d4io	8	6	with	with	IN
cord-296585-yfh5d4io	8	7	infection	infection	NN
cord-296585-yfh5d4io	8	8	caused	cause	VBN
cord-296585-yfh5d4io	8	9	by	by	IN
cord-296585-yfh5d4io	8	10	common	common	JJ
cord-296585-yfh5d4io	8	11	cold	cold	JJ
cord-296585-yfh5d4io	8	12	viruses	virus	NNS
cord-296585-yfh5d4io	8	13	or	or	CC
cord-296585-yfh5d4io	8	14	bacteria	bacteria	NNS
cord-296585-yfh5d4io	8	15	,	,	,
cord-296585-yfh5d4io	8	16	or	or	CC
cord-296585-yfh5d4io	8	17	co	co	NNS
cord-296585-yfh5d4io	8	18	-	-	NNS
cord-296585-yfh5d4io	8	19	infections	infection	NNS
cord-296585-yfh5d4io	8	20	.	.	.
cord-296585-yfh5d4io	9	1	Chronic	chronic	JJ
cord-296585-yfh5d4io	9	2	and	and	CC
cord-296585-yfh5d4io	9	3	persistent	persistent	JJ
cord-296585-yfh5d4io	9	4	infection	infection	NN
cord-296585-yfh5d4io	9	5	by	by	IN
cord-296585-yfh5d4io	9	6	non	non	JJ
cord-296585-yfh5d4io	9	7	-	-	JJ
cord-296585-yfh5d4io	9	8	typeable	typeable	JJ
cord-296585-yfh5d4io	9	9	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	9	10	influenzae	influenzae	NN
cord-296585-yfh5d4io	9	11	(	(	-LRB-
cord-296585-yfh5d4io	9	12	NTHi	NTHi	NNS
cord-296585-yfh5d4io	9	13	)	)	-RRB-
cord-296585-yfh5d4io	9	14	,	,	,
cord-296585-yfh5d4io	9	15	a	a	DT
cord-296585-yfh5d4io	9	16	Gram	gram	NN
cord-296585-yfh5d4io	9	17	-	-	HYPH
cord-296585-yfh5d4io	9	18	negative	negative	JJ
cord-296585-yfh5d4io	9	19	coccobacillus	coccobacillus	NN
cord-296585-yfh5d4io	9	20	,	,	,
cord-296585-yfh5d4io	9	21	contributes	contribute	VBZ
cord-296585-yfh5d4io	9	22	to	to	IN
cord-296585-yfh5d4io	9	23	almost	almost	RB
cord-296585-yfh5d4io	9	24	half	half	NN
cord-296585-yfh5d4io	9	25	of	of	IN
cord-296585-yfh5d4io	9	26	the	the	DT
cord-296585-yfh5d4io	9	27	infective	infective	JJ
cord-296585-yfh5d4io	9	28	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	9	29	caused	cause	VBN
cord-296585-yfh5d4io	9	30	by	by	IN
cord-296585-yfh5d4io	9	31	bacteria	bacteria	NNS
cord-296585-yfh5d4io	9	32	.	.	.
cord-296585-yfh5d4io	10	1	This	this	DT
cord-296585-yfh5d4io	10	2	is	be	VBZ
cord-296585-yfh5d4io	10	3	supported	support	VBN
cord-296585-yfh5d4io	10	4	by	by	IN
cord-296585-yfh5d4io	10	5	reports	report	NNS
cord-296585-yfh5d4io	10	6	that	that	IN
cord-296585-yfh5d4io	10	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	10	8	is	be	VBZ
cord-296585-yfh5d4io	10	9	commonly	commonly	RB
cord-296585-yfh5d4io	10	10	isolated	isolate	VBN
cord-296585-yfh5d4io	10	11	in	in	IN
cord-296585-yfh5d4io	10	12	the	the	DT
cord-296585-yfh5d4io	10	13	sputum	sputum	NN
cord-296585-yfh5d4io	10	14	from	from	IN
cord-296585-yfh5d4io	10	15	COPD	COPD	NNP
cord-296585-yfh5d4io	10	16	patients	patient	NNS
cord-296585-yfh5d4io	10	17	during	during	IN
cord-296585-yfh5d4io	10	18	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	10	19	.	.	.
cord-296585-yfh5d4io	11	1	Persistent	persistent	JJ
cord-296585-yfh5d4io	11	2	colonization	colonization	NN
cord-296585-yfh5d4io	11	3	of	of	IN
cord-296585-yfh5d4io	11	4	NTHi	NTHi	NNS
cord-296585-yfh5d4io	11	5	in	in	IN
cord-296585-yfh5d4io	11	6	the	the	DT
cord-296585-yfh5d4io	11	7	lower	low	JJR
cord-296585-yfh5d4io	11	8	airway	airway	NN
cord-296585-yfh5d4io	11	9	requires	require	VBZ
cord-296585-yfh5d4io	11	10	a	a	DT
cord-296585-yfh5d4io	11	11	plethora	plethora	NN
cord-296585-yfh5d4io	11	12	of	of	IN
cord-296585-yfh5d4io	11	13	phenotypic	phenotypic	JJ
cord-296585-yfh5d4io	11	14	adaptation	adaptation	NN
cord-296585-yfh5d4io	11	15	and	and	CC
cord-296585-yfh5d4io	11	16	virulent	virulent	JJ
cord-296585-yfh5d4io	11	17	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	11	18	that	that	WDT
cord-296585-yfh5d4io	11	19	are	be	VBP
cord-296585-yfh5d4io	11	20	developed	develop	VBN
cord-296585-yfh5d4io	11	21	over	over	IN
cord-296585-yfh5d4io	11	22	time	time	NN
cord-296585-yfh5d4io	11	23	to	to	TO
cord-296585-yfh5d4io	11	24	cope	cope	VB
cord-296585-yfh5d4io	11	25	with	with	IN
cord-296585-yfh5d4io	11	26	changing	change	VBG
cord-296585-yfh5d4io	11	27	environmental	environmental	JJ
cord-296585-yfh5d4io	11	28	pressures	pressure	NNS
cord-296585-yfh5d4io	11	29	in	in	IN
cord-296585-yfh5d4io	11	30	the	the	DT
cord-296585-yfh5d4io	11	31	airway	airway	NN
cord-296585-yfh5d4io	11	32	such	such	JJ
cord-296585-yfh5d4io	11	33	as	as	IN
cord-296585-yfh5d4io	11	34	host	host	NN
cord-296585-yfh5d4io	11	35	immuno	immuno	JJ
cord-296585-yfh5d4io	11	36	-	-	HYPH
cord-296585-yfh5d4io	11	37	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	11	38	response	response	NN
cord-296585-yfh5d4io	11	39	.	.	.
cord-296585-yfh5d4io	12	1	Chronic	chronic	JJ
cord-296585-yfh5d4io	12	2	inhalation	inhalation	NN
cord-296585-yfh5d4io	12	3	of	of	IN
cord-296585-yfh5d4io	12	4	noxious	noxious	JJ
cord-296585-yfh5d4io	12	5	irritants	irritant	NNS
cord-296585-yfh5d4io	12	6	in	in	IN
cord-296585-yfh5d4io	12	7	COPD	COPD	NNP
cord-296585-yfh5d4io	12	8	causes	cause	VBZ
cord-296585-yfh5d4io	12	9	a	a	DT
cord-296585-yfh5d4io	12	10	changed	change	VBN
cord-296585-yfh5d4io	12	11	balance	balance	NN
cord-296585-yfh5d4io	12	12	in	in	IN
cord-296585-yfh5d4io	12	13	the	the	DT
cord-296585-yfh5d4io	12	14	lung	lung	NN
cord-296585-yfh5d4io	12	15	microbiome	microbiome	NN
cord-296585-yfh5d4io	12	16	,	,	,
cord-296585-yfh5d4io	12	17	abnormal	abnormal	JJ
cord-296585-yfh5d4io	12	18	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	12	19	response	response	NN
cord-296585-yfh5d4io	12	20	,	,	,
cord-296585-yfh5d4io	12	21	and	and	CC
cord-296585-yfh5d4io	12	22	an	an	DT
cord-296585-yfh5d4io	12	23	impaired	impaired	JJ
cord-296585-yfh5d4io	12	24	airway	airway	NN
cord-296585-yfh5d4io	12	25	immune	immune	JJ
cord-296585-yfh5d4io	12	26	system	system	NN
cord-296585-yfh5d4io	12	27	.	.	.
cord-296585-yfh5d4io	13	1	These	these	DT
cord-296585-yfh5d4io	13	2	conditions	condition	NNS
cord-296585-yfh5d4io	13	3	significantly	significantly	RB
cord-296585-yfh5d4io	13	4	provide	provide	VBP
cord-296585-yfh5d4io	13	5	an	an	DT
cord-296585-yfh5d4io	13	6	opportunistic	opportunistic	JJ
cord-296585-yfh5d4io	13	7	platform	platform	NN
cord-296585-yfh5d4io	13	8	for	for	IN
cord-296585-yfh5d4io	13	9	NTHi	nthi	JJ
cord-296585-yfh5d4io	13	10	colonization	colonization	NN
cord-296585-yfh5d4io	13	11	and	and	CC
cord-296585-yfh5d4io	13	12	infection	infection	NN
cord-296585-yfh5d4io	13	13	resulting	result	VBG
cord-296585-yfh5d4io	13	14	in	in	IN
cord-296585-yfh5d4io	13	15	a	a	DT
cord-296585-yfh5d4io	13	16	“	"	``
cord-296585-yfh5d4io	13	17	vicious	vicious	JJ
cord-296585-yfh5d4io	13	18	circle	circle	NN
cord-296585-yfh5d4io	13	19	.	.	.
cord-296585-yfh5d4io	13	20	”	"	''
cord-296585-yfh5d4io	14	1	Episodes	episode	NNS
cord-296585-yfh5d4io	14	2	of	of	IN
cord-296585-yfh5d4io	14	3	large	large	JJ
cord-296585-yfh5d4io	14	4	inflammation	inflammation	NN
cord-296585-yfh5d4io	14	5	as	as	IN
cord-296585-yfh5d4io	14	6	the	the	DT
cord-296585-yfh5d4io	14	7	consequences	consequence	NNS
cord-296585-yfh5d4io	14	8	of	of	IN
cord-296585-yfh5d4io	14	9	multiple	multiple	JJ
cord-296585-yfh5d4io	14	10	interactions	interaction	NNS
cord-296585-yfh5d4io	14	11	between	between	IN
cord-296585-yfh5d4io	14	12	airway	airway	NN
cord-296585-yfh5d4io	14	13	immune	immune	JJ
cord-296585-yfh5d4io	14	14	cells	cell	NNS
cord-296585-yfh5d4io	14	15	and	and	CC
cord-296585-yfh5d4io	14	16	NTHi	NTHi	NNS
cord-296585-yfh5d4io	14	17	,	,	,
cord-296585-yfh5d4io	14	18	accumulatively	accumulatively	RB
cord-296585-yfh5d4io	14	19	contribute	contribute	VB
cord-296585-yfh5d4io	14	20	to	to	IN
cord-296585-yfh5d4io	14	21	COPD	COPD	NNP
cord-296585-yfh5d4io	14	22	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	14	23	and	and	CC
cord-296585-yfh5d4io	14	24	may	may	MD
cord-296585-yfh5d4io	14	25	result	result	VB
cord-296585-yfh5d4io	14	26	in	in	IN
cord-296585-yfh5d4io	14	27	worsening	worsen	VBG
cord-296585-yfh5d4io	14	28	of	of	IN
cord-296585-yfh5d4io	14	29	the	the	DT
cord-296585-yfh5d4io	14	30	clinical	clinical	JJ
cord-296585-yfh5d4io	14	31	status	status	NN
cord-296585-yfh5d4io	14	32	.	.	.
cord-296585-yfh5d4io	15	1	In	in	IN
cord-296585-yfh5d4io	15	2	this	this	DT
cord-296585-yfh5d4io	15	3	review	review	NN
cord-296585-yfh5d4io	15	4	,	,	,
cord-296585-yfh5d4io	15	5	we	-PRON-	PRP
cord-296585-yfh5d4io	15	6	discuss	discuss	VBP
cord-296585-yfh5d4io	15	7	in	in	IN
cord-296585-yfh5d4io	15	8	detail	detail	NN
cord-296585-yfh5d4io	15	9	the	the	DT
cord-296585-yfh5d4io	15	10	interplay	interplay	NN
cord-296585-yfh5d4io	15	11	and	and	CC
cord-296585-yfh5d4io	15	12	crosstalk	crosstalk	NN
cord-296585-yfh5d4io	15	13	between	between	IN
cord-296585-yfh5d4io	15	14	airway	airway	NN
cord-296585-yfh5d4io	15	15	immune	immune	JJ
cord-296585-yfh5d4io	15	16	residents	resident	NNS
cord-296585-yfh5d4io	15	17	and	and	CC
cord-296585-yfh5d4io	15	18	NTHi	NTHi	NNS
cord-296585-yfh5d4io	15	19	,	,	,
cord-296585-yfh5d4io	15	20	and	and	CC
cord-296585-yfh5d4io	15	21	their	-PRON-	PRP$
cord-296585-yfh5d4io	15	22	effect	effect	NN
cord-296585-yfh5d4io	15	23	in	in	IN
cord-296585-yfh5d4io	15	24	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	15	25	for	for	IN
cord-296585-yfh5d4io	15	26	better	well	JJR
cord-296585-yfh5d4io	15	27	understanding	understanding	NN
cord-296585-yfh5d4io	15	28	of	of	IN
cord-296585-yfh5d4io	15	29	NTHi	nthi	JJ
cord-296585-yfh5d4io	15	30	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	15	31	in	in	IN
cord-296585-yfh5d4io	15	32	COPD	COPD	NNP
cord-296585-yfh5d4io	15	33	patients	patient	NNS
cord-296585-yfh5d4io	15	34	.	.	.
cord-296585-yfh5d4io	16	1	The	the	DT
cord-296585-yfh5d4io	16	2	lungs	lung	NNS
cord-296585-yfh5d4io	16	3	are	be	VBP
cord-296585-yfh5d4io	16	4	vital	vital	JJ
cord-296585-yfh5d4io	16	5	organs	organ	NNS
cord-296585-yfh5d4io	16	6	involved	involve	VBN
cord-296585-yfh5d4io	16	7	in	in	IN
cord-296585-yfh5d4io	16	8	gas	gas	NN
cord-296585-yfh5d4io	16	9	exchange	exchange	NN
cord-296585-yfh5d4io	16	10	between	between	IN
cord-296585-yfh5d4io	16	11	the	the	DT
cord-296585-yfh5d4io	16	12	vascular	vascular	JJ
cord-296585-yfh5d4io	16	13	system	system	NN
cord-296585-yfh5d4io	16	14	and	and	CC
cord-296585-yfh5d4io	16	15	the	the	DT
cord-296585-yfh5d4io	16	16	external	external	JJ
cord-296585-yfh5d4io	16	17	environment	environment	NN
cord-296585-yfh5d4io	16	18	,	,	,
cord-296585-yfh5d4io	16	19	thus	thus	RB
cord-296585-yfh5d4io	16	20	they	-PRON-	PRP
cord-296585-yfh5d4io	16	21	are	be	VBP
cord-296585-yfh5d4io	16	22	greatly	greatly	RB
cord-296585-yfh5d4io	16	23	exposed	expose	VBN
cord-296585-yfh5d4io	16	24	to	to	IN
cord-296585-yfh5d4io	16	25	the	the	DT
cord-296585-yfh5d4io	16	26	environment	environment	NN
cord-296585-yfh5d4io	16	27	-	-	HYPH
cord-296585-yfh5d4io	16	28	derived	derive	VBN
cord-296585-yfh5d4io	16	29	microorganisms	microorganism	NNS
cord-296585-yfh5d4io	16	30	,	,	,
cord-296585-yfh5d4io	16	31	including	include	VBG
cord-296585-yfh5d4io	16	32	fungi	fungus	NNS
cord-296585-yfh5d4io	16	33	,	,	,
cord-296585-yfh5d4io	16	34	viruses	virus	NNS
cord-296585-yfh5d4io	16	35	,	,	,
cord-296585-yfh5d4io	16	36	and	and	CC
cord-296585-yfh5d4io	16	37	bacteria	bacteria	NNS
cord-296585-yfh5d4io	16	38	.	.	.
cord-296585-yfh5d4io	17	1	The	the	DT
cord-296585-yfh5d4io	17	2	bronchial	bronchial	JJ
cord-296585-yfh5d4io	17	3	tree	tree	NN
cord-296585-yfh5d4io	17	4	and	and	CC
cord-296585-yfh5d4io	17	5	parenchymal	parenchymal	NN
cord-296585-yfh5d4io	17	6	tissues	tissue	NNS
cord-296585-yfh5d4io	17	7	of	of	IN
cord-296585-yfh5d4io	17	8	the	the	DT
cord-296585-yfh5d4io	17	9	lungs	lung	NNS
cord-296585-yfh5d4io	17	10	,	,	,
cord-296585-yfh5d4io	17	11	that	that	IN
cord-296585-yfh5d4io	17	12	until	until	IN
cord-296585-yfh5d4io	17	13	recently	recently	RB
cord-296585-yfh5d4io	17	14	were	be	VBD
cord-296585-yfh5d4io	17	15	considered	consider	VBN
cord-296585-yfh5d4io	17	16	as	as	IN
cord-296585-yfh5d4io	17	17	sterile	sterile	JJ
cord-296585-yfh5d4io	17	18	,	,	,
cord-296585-yfh5d4io	17	19	are	be	VBP
cord-296585-yfh5d4io	17	20	colonized	colonize	VBN
cord-296585-yfh5d4io	17	21	by	by	IN
cord-296585-yfh5d4io	17	22	phylogenetically	phylogenetically	RB
cord-296585-yfh5d4io	17	23	-	-	HYPH
cord-296585-yfh5d4io	17	24	diverse	diverse	JJ
cord-296585-yfh5d4io	17	25	microbes	microbe	NNS
cord-296585-yfh5d4io	17	26	.	.	.
cord-296585-yfh5d4io	18	1	The	the	DT
cord-296585-yfh5d4io	18	2	genera	genus	NNS
cord-296585-yfh5d4io	18	3	of	of	IN
cord-296585-yfh5d4io	18	4	Firmicutes	Firmicutes	NNPS
cord-296585-yfh5d4io	18	5	,	,	,
cord-296585-yfh5d4io	18	6	Bacteroidetes	Bacteroidetes	NNPS
cord-296585-yfh5d4io	18	7	,	,	,
cord-296585-yfh5d4io	18	8	and	and	CC
cord-296585-yfh5d4io	18	9	Proteobacteria	Proteobacteria	NNP
cord-296585-yfh5d4io	18	10	are	be	VBP
cord-296585-yfh5d4io	18	11	the	the	DT
cord-296585-yfh5d4io	18	12	most	most	RBS
cord-296585-yfh5d4io	18	13	common	common	JJ
cord-296585-yfh5d4io	18	14	phyla	phylum	NNS
cord-296585-yfh5d4io	18	15	identified	identify	VBN
cord-296585-yfh5d4io	18	16	and	and	CC
cord-296585-yfh5d4io	18	17	represent	represent	VBP
cord-296585-yfh5d4io	18	18	60	60	CD
cord-296585-yfh5d4io	18	19	%	%	NN
cord-296585-yfh5d4io	18	20	of	of	IN
cord-296585-yfh5d4io	18	21	the	the	DT
cord-296585-yfh5d4io	18	22	total	total	JJ
cord-296585-yfh5d4io	18	23	bacterial	bacterial	JJ
cord-296585-yfh5d4io	18	24	microbiome	microbiome	NN
cord-296585-yfh5d4io	18	25	in	in	IN
cord-296585-yfh5d4io	18	26	the	the	DT
cord-296585-yfh5d4io	18	27	healthy	healthy	JJ
cord-296585-yfh5d4io	18	28	airway	airway	NN
cord-296585-yfh5d4io	18	29	(	(	-LRB-
cord-296585-yfh5d4io	18	30	1	1	CD
cord-296585-yfh5d4io	18	31	,	,	,
cord-296585-yfh5d4io	18	32	2	2	CD
cord-296585-yfh5d4io	18	33	)	)	-RRB-
cord-296585-yfh5d4io	18	34	.	.	.
cord-296585-yfh5d4io	19	1	The	the	DT
cord-296585-yfh5d4io	19	2	majority	majority	NN
cord-296585-yfh5d4io	19	3	of	of	IN
cord-296585-yfh5d4io	19	4	the	the	DT
cord-296585-yfh5d4io	19	5	lung	lung	NN
cord-296585-yfh5d4io	19	6	microbiota	microbiota	NN
cord-296585-yfh5d4io	19	7	belongs	belong	VBZ
cord-296585-yfh5d4io	19	8	to	to	IN
cord-296585-yfh5d4io	19	9	the	the	DT
cord-296585-yfh5d4io	19	10	normal	normal	JJ
cord-296585-yfh5d4io	19	11	flora	flora	NNS
cord-296585-yfh5d4io	19	12	that	that	WDT
cord-296585-yfh5d4io	19	13	play	play	VBP
cord-296585-yfh5d4io	19	14	an	an	DT
cord-296585-yfh5d4io	19	15	important	important	JJ
cord-296585-yfh5d4io	19	16	role	role	NN
cord-296585-yfh5d4io	19	17	in	in	IN
cord-296585-yfh5d4io	19	18	the	the	DT
cord-296585-yfh5d4io	19	19	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	19	20	epithelial	epithelial	JJ
cord-296585-yfh5d4io	19	21	integrity	integrity	NN
cord-296585-yfh5d4io	19	22	,	,	,
cord-296585-yfh5d4io	19	23	colonization	colonization	NN
cord-296585-yfh5d4io	19	24	resistance	resistance	NN
cord-296585-yfh5d4io	19	25	,	,	,
cord-296585-yfh5d4io	19	26	and	and	CC
cord-296585-yfh5d4io	19	27	homeostasis	homeostasis	NN
cord-296585-yfh5d4io	19	28	of	of	IN
cord-296585-yfh5d4io	19	29	the	the	DT
cord-296585-yfh5d4io	19	30	immune	immune	JJ
cord-296585-yfh5d4io	19	31	system	system	NN
cord-296585-yfh5d4io	19	32	in	in	IN
cord-296585-yfh5d4io	19	33	the	the	DT
cord-296585-yfh5d4io	19	34	respiratory	respiratory	JJ
cord-296585-yfh5d4io	19	35	tract	tract	NN
cord-296585-yfh5d4io	19	36	(	(	-LRB-
cord-296585-yfh5d4io	19	37	3	3	CD
cord-296585-yfh5d4io	19	38	)	)	-RRB-
cord-296585-yfh5d4io	19	39	.	.	.
cord-296585-yfh5d4io	20	1	A	a	DT
cord-296585-yfh5d4io	20	2	small	small	JJ
cord-296585-yfh5d4io	20	3	fraction	fraction	NN
cord-296585-yfh5d4io	20	4	of	of	IN
cord-296585-yfh5d4io	20	5	them	-PRON-	PRP
cord-296585-yfh5d4io	20	6	are	be	VBP
cord-296585-yfh5d4io	20	7	,	,	,
cord-296585-yfh5d4io	20	8	however	however	RB
cord-296585-yfh5d4io	20	9	,	,	,
cord-296585-yfh5d4io	20	10	potentially	potentially	RB
cord-296585-yfh5d4io	20	11	pathogenic	pathogenic	JJ
cord-296585-yfh5d4io	20	12	microorganisms	microorganism	NNS
cord-296585-yfh5d4io	20	13	that	that	WDT
cord-296585-yfh5d4io	20	14	are	be	VBP
cord-296585-yfh5d4io	20	15	involved	involve	VBN
cord-296585-yfh5d4io	20	16	in	in	IN
cord-296585-yfh5d4io	20	17	a	a	DT
cord-296585-yfh5d4io	20	18	variety	variety	NN
cord-296585-yfh5d4io	20	19	of	of	IN
cord-296585-yfh5d4io	20	20	lung	lung	NN
cord-296585-yfh5d4io	20	21	diseases	disease	NNS
cord-296585-yfh5d4io	20	22	,	,	,
cord-296585-yfh5d4io	20	23	as	as	IN
cord-296585-yfh5d4io	20	24	exemplified	exemplify	VBN
cord-296585-yfh5d4io	20	25	by	by	IN
cord-296585-yfh5d4io	20	26	the	the	DT
cord-296585-yfh5d4io	20	27	genus	genus	NN
cord-296585-yfh5d4io	20	28	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	20	29	.	.	.
cord-296585-yfh5d4io	21	1	Non	non	JJ
cord-296585-yfh5d4io	21	2	-	-	JJ
cord-296585-yfh5d4io	21	3	typeable	typeable	JJ
cord-296585-yfh5d4io	21	4	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	21	5	influenzae	influenzae	NN
cord-296585-yfh5d4io	21	6	(	(	-LRB-
cord-296585-yfh5d4io	21	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	21	8	)	)	-RRB-
cord-296585-yfh5d4io	21	9	is	be	VBZ
cord-296585-yfh5d4io	21	10	a	a	DT
cord-296585-yfh5d4io	21	11	Gram	Gram	NNP
cord-296585-yfh5d4io	21	12	-	-	HYPH
cord-296585-yfh5d4io	21	13	negative	negative	JJ
cord-296585-yfh5d4io	21	14	coccobacillus	coccobacillus	NN
cord-296585-yfh5d4io	21	15	that	that	WDT
cord-296585-yfh5d4io	21	16	are	be	VBP
cord-296585-yfh5d4io	21	17	commonly	commonly	RB
cord-296585-yfh5d4io	21	18	residing	reside	VBG
cord-296585-yfh5d4io	21	19	in	in	IN
cord-296585-yfh5d4io	21	20	the	the	DT
cord-296585-yfh5d4io	21	21	human	human	JJ
cord-296585-yfh5d4io	21	22	airways	airway	NNS
cord-296585-yfh5d4io	21	23	.	.	.
cord-296585-yfh5d4io	22	1	Uniquely	uniquely	RB
cord-296585-yfh5d4io	22	2	and	and	CC
cord-296585-yfh5d4io	22	3	yet	yet	RB
cord-296585-yfh5d4io	22	4	unexplained	unexplained	JJ
cord-296585-yfh5d4io	22	5	,	,	,
cord-296585-yfh5d4io	22	6	NTHi	NTHi	NNPS
cord-296585-yfh5d4io	22	7	is	be	VBZ
cord-296585-yfh5d4io	22	8	a	a	DT
cord-296585-yfh5d4io	22	9	commensal	commensal	NN
cord-296585-yfh5d4io	22	10	when	when	WRB
cord-296585-yfh5d4io	22	11	colonizing	colonize	VBG
cord-296585-yfh5d4io	22	12	the	the	DT
cord-296585-yfh5d4io	22	13	nasopharynx	nasopharynx	NN
cord-296585-yfh5d4io	22	14	or	or	CC
cord-296585-yfh5d4io	22	15	throat	throat	NN
cord-296585-yfh5d4io	22	16	,	,	,
cord-296585-yfh5d4io	22	17	but	but	CC
cord-296585-yfh5d4io	22	18	pathogenic	pathogenic	JJ
cord-296585-yfh5d4io	22	19	in	in	IN
cord-296585-yfh5d4io	22	20	the	the	DT
cord-296585-yfh5d4io	22	21	lower	low	JJR
cord-296585-yfh5d4io	22	22	airways	airway	NNS
cord-296585-yfh5d4io	22	23	triggering	trigger	VBG
cord-296585-yfh5d4io	22	24	a	a	DT
cord-296585-yfh5d4io	22	25	robust	robust	JJ
cord-296585-yfh5d4io	22	26	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	22	27	response	response	NN
cord-296585-yfh5d4io	22	28	[	[	-LRB-
cord-296585-yfh5d4io	22	29	for	for	IN
cord-296585-yfh5d4io	22	30	reviews	review	NNS
cord-296585-yfh5d4io	22	31	see	see	VBP
cord-296585-yfh5d4io	22	32	(	(	-LRB-
cord-296585-yfh5d4io	22	33	4	4	CD
cord-296585-yfh5d4io	22	34	,	,	,
cord-296585-yfh5d4io	22	35	5	5	CD
cord-296585-yfh5d4io	22	36	)	)	-RRB-
cord-296585-yfh5d4io	22	37	]	]	-RRB-
cord-296585-yfh5d4io	22	38	.	.	.
cord-296585-yfh5d4io	23	1	NTHi	NTHi	NNP
cord-296585-yfh5d4io	23	2	is	be	VBZ
cord-296585-yfh5d4io	23	3	considered	consider	VBN
cord-296585-yfh5d4io	23	4	a	a	DT
cord-296585-yfh5d4io	23	5	potential	potential	JJ
cord-296585-yfh5d4io	23	6	opportunistic	opportunistic	JJ
cord-296585-yfh5d4io	23	7	pathogen	pathogen	NN
cord-296585-yfh5d4io	23	8	as	as	IN
cord-296585-yfh5d4io	23	9	it	-PRON-	PRP
cord-296585-yfh5d4io	23	10	frequently	frequently	RB
cord-296585-yfh5d4io	23	11	infects	infect	VBZ
cord-296585-yfh5d4io	23	12	the	the	DT
cord-296585-yfh5d4io	23	13	lower	low	JJR
cord-296585-yfh5d4io	23	14	respiratory	respiratory	JJ
cord-296585-yfh5d4io	23	15	tract	tract	NN
cord-296585-yfh5d4io	23	16	of	of	IN
cord-296585-yfh5d4io	23	17	lungs	lung	NNS
cord-296585-yfh5d4io	23	18	with	with	IN
cord-296585-yfh5d4io	23	19	structural	structural	JJ
cord-296585-yfh5d4io	23	20	damage	damage	NN
cord-296585-yfh5d4io	23	21	as	as	IN
cord-296585-yfh5d4io	23	22	a	a	DT
cord-296585-yfh5d4io	23	23	consequence	consequence	NN
cord-296585-yfh5d4io	23	24	of	of	IN
cord-296585-yfh5d4io	23	25	non	non	JJ
cord-296585-yfh5d4io	23	26	-	-	JJ
cord-296585-yfh5d4io	23	27	infectious	infectious	JJ
cord-296585-yfh5d4io	23	28	lung	lung	NN
cord-296585-yfh5d4io	23	29	diseases	disease	NNS
cord-296585-yfh5d4io	23	30	or	or	CC
cord-296585-yfh5d4io	23	31	mechanical	mechanical	JJ
cord-296585-yfh5d4io	23	32	injuries	injury	NNS
cord-296585-yfh5d4io	23	33	.	.	.
cord-296585-yfh5d4io	24	1	Moreover	moreover	RB
cord-296585-yfh5d4io	24	2	,	,	,
cord-296585-yfh5d4io	24	3	NTHi	NTHi	VBZ
cord-296585-yfh5d4io	24	4	occasionally	occasionally	RB
cord-296585-yfh5d4io	24	5	causes	cause	VBZ
cord-296585-yfh5d4io	24	6	bronchitis	bronchitis	NN
cord-296585-yfh5d4io	24	7	and	and	CC
cord-296585-yfh5d4io	24	8	pneumonia	pneumonia	NN
cord-296585-yfh5d4io	24	9	(	(	-LRB-
cord-296585-yfh5d4io	24	10	6	6	CD
cord-296585-yfh5d4io	24	11	)	)	-RRB-
cord-296585-yfh5d4io	24	12	.	.	.
cord-296585-yfh5d4io	25	1	In	in	IN
cord-296585-yfh5d4io	25	2	addition	addition	NN
cord-296585-yfh5d4io	25	3	,	,	,
cord-296585-yfh5d4io	25	4	lower	low	JJR
cord-296585-yfh5d4io	25	5	airway	airway	NN
cord-296585-yfh5d4io	25	6	colonization	colonization	NN
cord-296585-yfh5d4io	25	7	by	by	IN
cord-296585-yfh5d4io	25	8	NTHi	NTHi	NNS
cord-296585-yfh5d4io	25	9	has	have	VBZ
cord-296585-yfh5d4io	25	10	been	be	VBN
cord-296585-yfh5d4io	25	11	associated	associate	VBN
cord-296585-yfh5d4io	25	12	with	with	IN
cord-296585-yfh5d4io	25	13	disease	disease	NN
cord-296585-yfh5d4io	25	14	progression	progression	NN
cord-296585-yfh5d4io	25	15	of	of	IN
cord-296585-yfh5d4io	25	16	several	several	JJ
cord-296585-yfh5d4io	25	17	more	more	JJR
cord-296585-yfh5d4io	25	18	or	or	CC
cord-296585-yfh5d4io	25	19	less	less	RBR
cord-296585-yfh5d4io	25	20	non	non	JJ
cord-296585-yfh5d4io	25	21	-	-	JJ
cord-296585-yfh5d4io	25	22	infectious	infectious	JJ
cord-296585-yfh5d4io	25	23	lung	lung	NN
cord-296585-yfh5d4io	25	24	diseases	disease	NNS
cord-296585-yfh5d4io	25	25	such	such	JJ
cord-296585-yfh5d4io	25	26	as	as	IN
cord-296585-yfh5d4io	25	27	bronchiectasis	bronchiectasis	NNP
cord-296585-yfh5d4io	25	28	(	(	-LRB-
cord-296585-yfh5d4io	25	29	7	7	CD
cord-296585-yfh5d4io	25	30	)	)	-RRB-
cord-296585-yfh5d4io	25	31	,	,	,
cord-296585-yfh5d4io	25	32	cystic	cystic	JJ
cord-296585-yfh5d4io	25	33	fibrosis	fibrosis	NN
cord-296585-yfh5d4io	25	34	(	(	-LRB-
cord-296585-yfh5d4io	25	35	8)	8)	NNP
cord-296585-yfh5d4io	25	36	,	,	,
cord-296585-yfh5d4io	25	37	interstitial	interstitial	JJ
cord-296585-yfh5d4io	25	38	lung	lung	NN
cord-296585-yfh5d4io	25	39	diseases	disease	NNS
cord-296585-yfh5d4io	25	40	(	(	-LRB-
cord-296585-yfh5d4io	25	41	9	9	CD
cord-296585-yfh5d4io	25	42	,	,	,
cord-296585-yfh5d4io	25	43	10	10	CD
cord-296585-yfh5d4io	25	44	)	)	-RRB-
cord-296585-yfh5d4io	25	45	,	,	,
cord-296585-yfh5d4io	25	46	but	but	CC
cord-296585-yfh5d4io	25	47	mostly	mostly	RB
cord-296585-yfh5d4io	25	48	in	in	IN
cord-296585-yfh5d4io	25	49	chronic	chronic	JJ
cord-296585-yfh5d4io	25	50	obstructive	obstructive	JJ
cord-296585-yfh5d4io	25	51	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	25	52	disease	disease	NN
cord-296585-yfh5d4io	25	53	(	(	-LRB-
cord-296585-yfh5d4io	25	54	COPD	COPD	NNP
cord-296585-yfh5d4io	25	55	)	)	-RRB-
cord-296585-yfh5d4io	25	56	(	(	-LRB-
cord-296585-yfh5d4io	25	57	11	11	CD
cord-296585-yfh5d4io	25	58	,	,	,
cord-296585-yfh5d4io	25	59	12	12	CD
cord-296585-yfh5d4io	25	60	)	)	-RRB-
cord-296585-yfh5d4io	25	61	.	.	.
cord-296585-yfh5d4io	26	1	COPD	COPD	NNP
cord-296585-yfh5d4io	26	2	is	be	VBZ
cord-296585-yfh5d4io	26	3	a	a	DT
cord-296585-yfh5d4io	26	4	severe	severe	JJ
cord-296585-yfh5d4io	26	5	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	26	6	lung	lung	NN
cord-296585-yfh5d4io	26	7	disease	disease	NN
cord-296585-yfh5d4io	26	8	characterized	characterize	VBN
cord-296585-yfh5d4io	26	9	by	by	IN
cord-296585-yfh5d4io	26	10	airflow	airflow	NN
cord-296585-yfh5d4io	26	11	limitation	limitation	NN
cord-296585-yfh5d4io	26	12	with	with	IN
cord-296585-yfh5d4io	26	13	a	a	DT
cord-296585-yfh5d4io	26	14	range	range	NN
cord-296585-yfh5d4io	26	15	of	of	IN
cord-296585-yfh5d4io	26	16	pathological	pathological	JJ
cord-296585-yfh5d4io	26	17	changes	change	NNS
cord-296585-yfh5d4io	26	18	.	.	.
cord-296585-yfh5d4io	27	1	Both	both	DT
cord-296585-yfh5d4io	27	2	genetics	genetic	NNS
cord-296585-yfh5d4io	27	3	and	and	CC
cord-296585-yfh5d4io	27	4	environmental	environmental	JJ
cord-296585-yfh5d4io	27	5	factors	factor	NNS
cord-296585-yfh5d4io	27	6	trigger	trigger	VBP
cord-296585-yfh5d4io	27	7	the	the	DT
cord-296585-yfh5d4io	27	8	onset	onset	NN
cord-296585-yfh5d4io	27	9	of	of	IN
cord-296585-yfh5d4io	27	10	COPD	COPD	NNP
cord-296585-yfh5d4io	27	11	,	,	,
cord-296585-yfh5d4io	27	12	however	however	RB
cord-296585-yfh5d4io	27	13	,	,	,
cord-296585-yfh5d4io	27	14	microbes	microbe	NNS
cord-296585-yfh5d4io	27	15	including	include	VBG
cord-296585-yfh5d4io	27	16	NTHi	NTHi	NNS
cord-296585-yfh5d4io	27	17	play	play	VBP
cord-296585-yfh5d4io	27	18	an	an	DT
cord-296585-yfh5d4io	27	19	important	important	JJ
cord-296585-yfh5d4io	27	20	role	role	NN
cord-296585-yfh5d4io	27	21	in	in	IN
cord-296585-yfh5d4io	27	22	the	the	DT
cord-296585-yfh5d4io	27	23	acute	acute	JJ
cord-296585-yfh5d4io	27	24	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	27	25	.	.	.
cord-296585-yfh5d4io	28	1	This	this	DT
cord-296585-yfh5d4io	28	2	review	review	NN
cord-296585-yfh5d4io	28	3	describes	describe	VBZ
cord-296585-yfh5d4io	28	4	the	the	DT
cord-296585-yfh5d4io	28	5	disease	disease	NN
cord-296585-yfh5d4io	28	6	progression	progression	NN
cord-296585-yfh5d4io	28	7	of	of	IN
cord-296585-yfh5d4io	28	8	COPD	COPD	NNP
cord-296585-yfh5d4io	28	9	in	in	IN
cord-296585-yfh5d4io	28	10	the	the	DT
cord-296585-yfh5d4io	28	11	context	context	NN
cord-296585-yfh5d4io	28	12	of	of	IN
cord-296585-yfh5d4io	28	13	host	host	NN
cord-296585-yfh5d4io	28	14	immuneinteractions	immuneinteraction	NNS
cord-296585-yfh5d4io	28	15	linked	link	VBN
cord-296585-yfh5d4io	28	16	to	to	IN
cord-296585-yfh5d4io	28	17	NTHi	NTHi	NNS
cord-296585-yfh5d4io	28	18	,	,	,
cord-296585-yfh5d4io	28	19	and	and	CC
cord-296585-yfh5d4io	28	20	the	the	DT
cord-296585-yfh5d4io	28	21	overall	overall	JJ
cord-296585-yfh5d4io	28	22	impact	impact	NN
cord-296585-yfh5d4io	28	23	in	in	IN
cord-296585-yfh5d4io	28	24	disease	disease	NN
cord-296585-yfh5d4io	28	25	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	28	26	.	.	.
cord-296585-yfh5d4io	29	1	COPD	COPD	NNP
cord-296585-yfh5d4io	29	2	is	be	VBZ
cord-296585-yfh5d4io	29	3	the	the	DT
cord-296585-yfh5d4io	29	4	third	third	JJ
cord-296585-yfh5d4io	29	5	leading	leading	JJ
cord-296585-yfh5d4io	29	6	cause	cause	NN
cord-296585-yfh5d4io	29	7	of	of	IN
cord-296585-yfh5d4io	29	8	morbidity	morbidity	NN
cord-296585-yfh5d4io	29	9	and	and	CC
cord-296585-yfh5d4io	29	10	mortality	mortality	NN
cord-296585-yfh5d4io	29	11	worldwide	worldwide	RB
cord-296585-yfh5d4io	29	12	expected	expect	VBN
cord-296585-yfh5d4io	29	13	to	to	TO
cord-296585-yfh5d4io	29	14	affect	affect	VB
cord-296585-yfh5d4io	29	15	more	more	JJR
cord-296585-yfh5d4io	29	16	than	than	IN
cord-296585-yfh5d4io	29	17	210	210	CD
cord-296585-yfh5d4io	29	18	million	million	CD
cord-296585-yfh5d4io	29	19	people	people	NNS
cord-296585-yfh5d4io	29	20	by	by	IN
cord-296585-yfh5d4io	29	21	2030	2030	CD
cord-296585-yfh5d4io	29	22	(	(	-LRB-
cord-296585-yfh5d4io	29	23	13	13	CD
cord-296585-yfh5d4io	29	24	,	,	,
cord-296585-yfh5d4io	29	25	14	14	CD
cord-296585-yfh5d4io	29	26	)	)	-RRB-
cord-296585-yfh5d4io	29	27	.	.	.
cord-296585-yfh5d4io	30	1	According	accord	VBG
cord-296585-yfh5d4io	30	2	to	to	IN
cord-296585-yfh5d4io	30	3	the	the	DT
cord-296585-yfh5d4io	30	4	Global	Global	NNP
cord-296585-yfh5d4io	30	5	Initiative	Initiative	NNP
cord-296585-yfh5d4io	30	6	for	for	IN
cord-296585-yfh5d4io	30	7	Chronic	Chronic	NNP
cord-296585-yfh5d4io	30	8	Obstructive	Obstructive	NNP
cord-296585-yfh5d4io	30	9	Lung	Lung	NNP
cord-296585-yfh5d4io	30	10	Disease	Disease	NNP
cord-296585-yfh5d4io	30	11	(	(	-LRB-
cord-296585-yfh5d4io	30	12	GOLD	GOLD	NNP
cord-296585-yfh5d4io	30	13	)	)	-RRB-
cord-296585-yfh5d4io	30	14	,	,	,
cord-296585-yfh5d4io	30	15	COPD	COPD	NNP
cord-296585-yfh5d4io	30	16	is	be	VBZ
cord-296585-yfh5d4io	30	17	a	a	DT
cord-296585-yfh5d4io	30	18	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	30	19	disease	disease	NN
cord-296585-yfh5d4io	30	20	that	that	WDT
cord-296585-yfh5d4io	30	21	is	be	VBZ
cord-296585-yfh5d4io	30	22	manageable	manageable	JJ
cord-296585-yfh5d4io	30	23	,	,	,
cord-296585-yfh5d4io	30	24	but	but	CC
cord-296585-yfh5d4io	30	25	significant	significant	JJ
cord-296585-yfh5d4io	30	26	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	30	27	and	and	CC
cord-296585-yfh5d4io	30	28	co	co	NNS
cord-296585-yfh5d4io	30	29	-	-	NNS
cord-296585-yfh5d4io	30	30	morbidities	morbidity	NNS
cord-296585-yfh5d4io	30	31	may	may	MD
cord-296585-yfh5d4io	30	32	,	,	,
cord-296585-yfh5d4io	30	33	however	however	RB
cord-296585-yfh5d4io	30	34	,	,	,
cord-296585-yfh5d4io	30	35	contribute	contribute	VB
cord-296585-yfh5d4io	30	36	to	to	IN
cord-296585-yfh5d4io	30	37	the	the	DT
cord-296585-yfh5d4io	30	38	overall	overall	JJ
cord-296585-yfh5d4io	30	39	severity	severity	NN
cord-296585-yfh5d4io	30	40	in	in	IN
cord-296585-yfh5d4io	30	41	individual	individual	JJ
cord-296585-yfh5d4io	30	42	patients	patient	NNS
cord-296585-yfh5d4io	30	43	(	(	-LRB-
cord-296585-yfh5d4io	30	44	15	15	CD
cord-296585-yfh5d4io	30	45	)	)	-RRB-
cord-296585-yfh5d4io	30	46	.	.	.
cord-296585-yfh5d4io	31	1	COPD	COPD	NNP
cord-296585-yfh5d4io	31	2	is	be	VBZ
cord-296585-yfh5d4io	31	3	characterized	characterize	VBN
cord-296585-yfh5d4io	31	4	by	by	IN
cord-296585-yfh5d4io	31	5	chronic	chronic	JJ
cord-296585-yfh5d4io	31	6	airflow	airflow	NN
cord-296585-yfh5d4io	31	7	limitation	limitation	NN
cord-296585-yfh5d4io	31	8	of	of	IN
cord-296585-yfh5d4io	31	9	the	the	DT
cord-296585-yfh5d4io	31	10	peripheral	peripheral	JJ
cord-296585-yfh5d4io	31	11	airways	airway	NNS
cord-296585-yfh5d4io	31	12	with	with	IN
cord-296585-yfh5d4io	31	13	a	a	DT
cord-296585-yfh5d4io	31	14	range	range	NN
cord-296585-yfh5d4io	31	15	of	of	IN
cord-296585-yfh5d4io	31	16	pathological	pathological	JJ
cord-296585-yfh5d4io	31	17	changes	change	NNS
cord-296585-yfh5d4io	31	18	in	in	IN
cord-296585-yfh5d4io	31	19	the	the	DT
cord-296585-yfh5d4io	31	20	lung	lung	NN
cord-296585-yfh5d4io	31	21	that	that	WDT
cord-296585-yfh5d4io	31	22	are	be	VBP
cord-296585-yfh5d4io	31	23	not	not	RB
cord-296585-yfh5d4io	31	24	fully	fully	RB
cord-296585-yfh5d4io	31	25	reversible	reversible	JJ
cord-296585-yfh5d4io	31	26	,	,	,
cord-296585-yfh5d4io	31	27	and	and	CC
cord-296585-yfh5d4io	31	28	usually	usually	RB
cord-296585-yfh5d4io	31	29	become	become	VBP
cord-296585-yfh5d4io	31	30	progressively	progressively	RB
cord-296585-yfh5d4io	31	31	worse	bad	JJR
cord-296585-yfh5d4io	31	32	over	over	IN
cord-296585-yfh5d4io	31	33	time	time	NN
cord-296585-yfh5d4io	31	34	.	.	.
cord-296585-yfh5d4io	32	1	The	the	DT
cord-296585-yfh5d4io	32	2	progression	progression	NN
cord-296585-yfh5d4io	32	3	of	of	IN
cord-296585-yfh5d4io	32	4	COPD	COPD	NNP
cord-296585-yfh5d4io	32	5	is	be	VBZ
cord-296585-yfh5d4io	32	6	associated	associate	VBN
cord-296585-yfh5d4io	32	7	with	with	IN
cord-296585-yfh5d4io	32	8	an	an	DT
cord-296585-yfh5d4io	32	9	abnormal	abnormal	JJ
cord-296585-yfh5d4io	32	10	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	32	11	response	response	NN
cord-296585-yfh5d4io	32	12	of	of	IN
cord-296585-yfh5d4io	32	13	the	the	DT
cord-296585-yfh5d4io	32	14	lung	lung	NN
cord-296585-yfh5d4io	32	15	to	to	IN
cord-296585-yfh5d4io	32	16	noxious	noxious	JJ
cord-296585-yfh5d4io	32	17	particles	particle	NNS
cord-296585-yfh5d4io	32	18	or	or	CC
cord-296585-yfh5d4io	32	19	gases	gas	NNS
cord-296585-yfh5d4io	32	20	.	.	.
cord-296585-yfh5d4io	33	1	From	from	IN
cord-296585-yfh5d4io	33	2	a	a	DT
cord-296585-yfh5d4io	33	3	pathological	pathological	JJ
cord-296585-yfh5d4io	33	4	point	point	NN
cord-296585-yfh5d4io	33	5	of	of	IN
cord-296585-yfh5d4io	33	6	view	view	NN
cord-296585-yfh5d4io	33	7	,	,	,
cord-296585-yfh5d4io	33	8	COPD	COPD	NNP
cord-296585-yfh5d4io	33	9	comprises	comprise	VBZ
cord-296585-yfh5d4io	33	10	a	a	DT
cord-296585-yfh5d4io	33	11	group	group	NN
cord-296585-yfh5d4io	33	12	of	of	IN
cord-296585-yfh5d4io	33	13	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	33	14	abnormalities	abnormality	NNS
cord-296585-yfh5d4io	33	15	related	relate	VBN
cord-296585-yfh5d4io	33	16	to	to	IN
cord-296585-yfh5d4io	33	17	the	the	DT
cord-296585-yfh5d4io	33	18	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	33	19	reaction	reaction	NN
cord-296585-yfh5d4io	33	20	of	of	IN
cord-296585-yfh5d4io	33	21	the	the	DT
cord-296585-yfh5d4io	33	22	airways	airway	NNS
cord-296585-yfh5d4io	33	23	,	,	,
cord-296585-yfh5d4io	33	24	alveoli	alveolus	NNS
cord-296585-yfh5d4io	33	25	,	,	,
cord-296585-yfh5d4io	33	26	and	and	CC
cord-296585-yfh5d4io	33	27	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	33	28	vessels	vessel	NNS
cord-296585-yfh5d4io	33	29	(	(	-LRB-
cord-296585-yfh5d4io	33	30	16	16	CD
cord-296585-yfh5d4io	33	31	)	)	-RRB-
cord-296585-yfh5d4io	34	1	(	(	-LRB-
cord-296585-yfh5d4io	34	2	17	17	CD
cord-296585-yfh5d4io	34	3	)	)	-RRB-
cord-296585-yfh5d4io	35	1	(	(	-LRB-
cord-296585-yfh5d4io	35	2	18	18	CD
cord-296585-yfh5d4io	35	3	)	)	-RRB-
cord-296585-yfh5d4io	35	4	(	(	-LRB-
cord-296585-yfh5d4io	35	5	19	19	CD
cord-296585-yfh5d4io	35	6	)	)	-RRB-
cord-296585-yfh5d4io	35	7	.	.	.
cord-296585-yfh5d4io	36	1	These	these	DT
cord-296585-yfh5d4io	36	2	include	include	VBP
cord-296585-yfh5d4io	36	3	(	(	-LRB-
cord-296585-yfh5d4io	36	4	i	i	NN
cord-296585-yfh5d4io	36	5	)	)	-RRB-
cord-296585-yfh5d4io	36	6	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	36	7	emphysema	emphysema	NN
cord-296585-yfh5d4io	36	8	,	,	,
cord-296585-yfh5d4io	36	9	(	(	-LRB-
cord-296585-yfh5d4io	36	10	ii	ii	NN
cord-296585-yfh5d4io	36	11	)	)	-RRB-
cord-296585-yfh5d4io	36	12	chronic	chronic	JJ
cord-296585-yfh5d4io	36	13	bronchitis	bronchitis	NN
cord-296585-yfh5d4io	36	14	,	,	,
cord-296585-yfh5d4io	36	15	and	and	CC
cord-296585-yfh5d4io	36	16	(	(	-LRB-
cord-296585-yfh5d4io	36	17	iii	iii	NN
cord-296585-yfh5d4io	36	18	)	)	-RRB-
cord-296585-yfh5d4io	36	19	disease	disease	NN
cord-296585-yfh5d4io	36	20	in	in	IN
cord-296585-yfh5d4io	36	21	the	the	DT
cord-296585-yfh5d4io	36	22	small	small	JJ
cord-296585-yfh5d4io	36	23	airways	airway	NNS
cord-296585-yfh5d4io	36	24	.	.	.
cord-296585-yfh5d4io	37	1	The	the	DT
cord-296585-yfh5d4io	37	2	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	37	3	abnormalities	abnormality	NNS
cord-296585-yfh5d4io	37	4	progressively	progressively	RB
cord-296585-yfh5d4io	37	5	affect	affect	VBP
cord-296585-yfh5d4io	37	6	all	all	DT
cord-296585-yfh5d4io	37	7	parts	part	NNS
cord-296585-yfh5d4io	37	8	of	of	IN
cord-296585-yfh5d4io	37	9	the	the	DT
cord-296585-yfh5d4io	37	10	lung	lung	NN
cord-296585-yfh5d4io	37	11	,	,	,
cord-296585-yfh5d4io	37	12	resulting	result	VBG
cord-296585-yfh5d4io	37	13	in	in	IN
cord-296585-yfh5d4io	37	14	increased	increase	VBN
cord-296585-yfh5d4io	37	15	resistance	resistance	NN
cord-296585-yfh5d4io	37	16	of	of	IN
cord-296585-yfh5d4io	37	17	the	the	DT
cord-296585-yfh5d4io	37	18	conducting	conduct	VBG
cord-296585-yfh5d4io	37	19	airways	airway	NNS
cord-296585-yfh5d4io	37	20	and	and	CC
cord-296585-yfh5d4io	37	21	thus	thus	RB
cord-296585-yfh5d4io	37	22	chronic	chronic	JJ
cord-296585-yfh5d4io	37	23	airflow	airflow	NN
cord-296585-yfh5d4io	37	24	obstruction	obstruction	NN
cord-296585-yfh5d4io	37	25	that	that	WDT
cord-296585-yfh5d4io	37	26	eventually	eventually	RB
cord-296585-yfh5d4io	37	27	will	will	MD
cord-296585-yfh5d4io	37	28	lead	lead	VB
cord-296585-yfh5d4io	37	29	to	to	IN
cord-296585-yfh5d4io	37	30	a	a	DT
cord-296585-yfh5d4io	37	31	declined	decline	VBN
cord-296585-yfh5d4io	37	32	lung	lung	NN
cord-296585-yfh5d4io	37	33	function	function	NN
cord-296585-yfh5d4io	37	34	.	.	.
cord-296585-yfh5d4io	38	1	Emphysema	emphysema	NN
cord-296585-yfh5d4io	38	2	is	be	VBZ
cord-296585-yfh5d4io	38	3	a	a	DT
cord-296585-yfh5d4io	38	4	permanent	permanent	JJ
cord-296585-yfh5d4io	38	5	loss	loss	NN
cord-296585-yfh5d4io	38	6	of	of	IN
cord-296585-yfh5d4io	38	7	elastic	elastic	JJ
cord-296585-yfh5d4io	38	8	lung	lung	NN
cord-296585-yfh5d4io	38	9	recoil	recoil	NN
cord-296585-yfh5d4io	38	10	caused	cause	VBN
cord-296585-yfh5d4io	38	11	by	by	IN
cord-296585-yfh5d4io	38	12	elastolytic	elastolytic	JJ
cord-296585-yfh5d4io	38	13	destruction	destruction	NN
cord-296585-yfh5d4io	38	14	and	and	CC
cord-296585-yfh5d4io	38	15	enlargement	enlargement	NN
cord-296585-yfh5d4io	38	16	of	of	IN
cord-296585-yfh5d4io	38	17	the	the	DT
cord-296585-yfh5d4io	38	18	alveolar	alveolar	JJ
cord-296585-yfh5d4io	38	19	wall	wall	NN
cord-296585-yfh5d4io	38	20	distal	distal	JJ
cord-296585-yfh5d4io	38	21	to	to	IN
cord-296585-yfh5d4io	38	22	the	the	DT
cord-296585-yfh5d4io	38	23	terminal	terminal	JJ
cord-296585-yfh5d4io	38	24	bronchioles	bronchiole	NNS
cord-296585-yfh5d4io	38	25	.	.	.
cord-296585-yfh5d4io	39	1	This	this	DT
cord-296585-yfh5d4io	39	2	consequently	consequently	RB
cord-296585-yfh5d4io	39	3	results	result	VBZ
cord-296585-yfh5d4io	39	4	in	in	IN
cord-296585-yfh5d4io	39	5	the	the	DT
cord-296585-yfh5d4io	39	6	loss	loss	NN
cord-296585-yfh5d4io	39	7	of	of	IN
cord-296585-yfh5d4io	39	8	alveolar	alveolar	JJ
cord-296585-yfh5d4io	39	9	attachments	attachment	NNS
cord-296585-yfh5d4io	39	10	to	to	IN
cord-296585-yfh5d4io	39	11	the	the	DT
cord-296585-yfh5d4io	39	12	small	small	JJ
cord-296585-yfh5d4io	39	13	airways	airway	NNS
cord-296585-yfh5d4io	39	14	and	and	CC
cord-296585-yfh5d4io	39	15	thus	thus	RB
cord-296585-yfh5d4io	39	16	limitation	limitation	NN
cord-296585-yfh5d4io	39	17	of	of	IN
cord-296585-yfh5d4io	39	18	airflow	airflow	NN
cord-296585-yfh5d4io	39	19	and	and	CC
cord-296585-yfh5d4io	39	20	gaseous	gaseous	JJ
cord-296585-yfh5d4io	39	21	exchanges	exchange	NNS
cord-296585-yfh5d4io	39	22	.	.	.
cord-296585-yfh5d4io	40	1	Chronic	chronic	JJ
cord-296585-yfh5d4io	40	2	bronchitis	bronchitis	NN
cord-296585-yfh5d4io	40	3	is	be	VBZ
cord-296585-yfh5d4io	40	4	characterized	characterize	VBN
cord-296585-yfh5d4io	40	5	by	by	IN
cord-296585-yfh5d4io	40	6	consecutive	consecutive	JJ
cord-296585-yfh5d4io	40	7	and	and	CC
cord-296585-yfh5d4io	40	8	chronic	chronic	JJ
cord-296585-yfh5d4io	40	9	cough	cough	NN
cord-296585-yfh5d4io	40	10	with	with	IN
cord-296585-yfh5d4io	40	11	expectorations	expectoration	NNS
cord-296585-yfh5d4io	40	12	that	that	WDT
cord-296585-yfh5d4io	40	13	last	last	VBP
cord-296585-yfh5d4io	40	14	for	for	IN
cord-296585-yfh5d4io	40	15	more	more	JJR
cord-296585-yfh5d4io	40	16	than	than	IN
cord-296585-yfh5d4io	40	17	3	3	CD
cord-296585-yfh5d4io	40	18	months	month	NNS
cord-296585-yfh5d4io	40	19	within	within	IN
cord-296585-yfh5d4io	40	20	2	2	CD
cord-296585-yfh5d4io	40	21	years	year	NNS
cord-296585-yfh5d4io	40	22	.	.	.
cord-296585-yfh5d4io	41	1	It	-PRON-	PRP
cord-296585-yfh5d4io	41	2	is	be	VBZ
cord-296585-yfh5d4io	41	3	associated	associate	VBN
cord-296585-yfh5d4io	41	4	with	with	IN
cord-296585-yfh5d4io	41	5	inflammation	inflammation	NN
cord-296585-yfh5d4io	41	6	of	of	IN
cord-296585-yfh5d4io	41	7	the	the	DT
cord-296585-yfh5d4io	41	8	bronchial	bronchial	JJ
cord-296585-yfh5d4io	41	9	walls	wall	NNS
cord-296585-yfh5d4io	41	10	with	with	IN
cord-296585-yfh5d4io	41	11	increased	increase	VBN
cord-296585-yfh5d4io	41	12	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	41	13	infiltrates	infiltrate	NNS
cord-296585-yfh5d4io	41	14	,	,	,
cord-296585-yfh5d4io	41	15	hyperplasia	hyperplasia	NN
cord-296585-yfh5d4io	41	16	of	of	IN
cord-296585-yfh5d4io	41	17	goblet	goblet	NN
cord-296585-yfh5d4io	41	18	cells	cell	NNS
cord-296585-yfh5d4io	41	19	,	,	,
cord-296585-yfh5d4io	41	20	hypertrophy	hypertrophy	NN
cord-296585-yfh5d4io	41	21	of	of	IN
cord-296585-yfh5d4io	41	22	tracheobronchial	tracheobronchial	NNP
cord-296585-yfh5d4io	41	23	submucosa	submucosa	NNP
cord-296585-yfh5d4io	41	24	,	,	,
cord-296585-yfh5d4io	41	25	increased	increase	VBD
cord-296585-yfh5d4io	41	26	mucous	mucous	JJ
cord-296585-yfh5d4io	41	27	secretion	secretion	NN
cord-296585-yfh5d4io	41	28	and	and	CC
cord-296585-yfh5d4io	41	29	,	,	,
cord-296585-yfh5d4io	41	30	finally	finally	RB
cord-296585-yfh5d4io	41	31	,	,	,
cord-296585-yfh5d4io	41	32	dilatation	dilatation	NN
cord-296585-yfh5d4io	41	33	of	of	IN
cord-296585-yfh5d4io	41	34	the	the	DT
cord-296585-yfh5d4io	41	35	airway	airway	NN
cord-296585-yfh5d4io	41	36	ducts	duct	NNS
cord-296585-yfh5d4io	41	37	(	(	-LRB-
cord-296585-yfh5d4io	41	38	airways	airway	NNS
cord-296585-yfh5d4io	41	39	of	of	IN
cord-296585-yfh5d4io	41	40	about	about	RB
cord-296585-yfh5d4io	41	41	2	2	CD
cord-296585-yfh5d4io	41	42	-	-	SYM
cord-296585-yfh5d4io	41	43	4	4	CD
cord-296585-yfh5d4io	41	44	mm	mm	NN
cord-296585-yfh5d4io	41	45	in	in	IN
cord-296585-yfh5d4io	41	46	internal	internal	JJ
cord-296585-yfh5d4io	41	47	diameter	diameter	NN
cord-296585-yfh5d4io	41	48	)	)	-RRB-
cord-296585-yfh5d4io	41	49	.	.	.
cord-296585-yfh5d4io	42	1	The	the	DT
cord-296585-yfh5d4io	42	2	majority	majority	NN
cord-296585-yfh5d4io	42	3	of	of	IN
cord-296585-yfh5d4io	42	4	the	the	DT
cord-296585-yfh5d4io	42	5	ciliated	ciliated	JJ
cord-296585-yfh5d4io	42	6	epithelium	epithelium	NN
cord-296585-yfh5d4io	42	7	lining	line	VBG
cord-296585-yfh5d4io	42	8	the	the	DT
cord-296585-yfh5d4io	42	9	airways	airway	NNS
cord-296585-yfh5d4io	42	10	are	be	VBP
cord-296585-yfh5d4io	42	11	also	also	RB
cord-296585-yfh5d4io	42	12	either	either	CC
cord-296585-yfh5d4io	42	13	compromised	compromised	JJ
cord-296585-yfh5d4io	42	14	or	or	CC
cord-296585-yfh5d4io	42	15	dysfunctionnal	dysfunctionnal	JJ
cord-296585-yfh5d4io	42	16	,	,	,
cord-296585-yfh5d4io	42	17	and	and	CC
cord-296585-yfh5d4io	42	18	may	may	MD
cord-296585-yfh5d4io	42	19	be	be	VB
cord-296585-yfh5d4io	42	20	replaced	replace	VBN
cord-296585-yfh5d4io	42	21	by	by	IN
cord-296585-yfh5d4io	42	22	nonciliated	nonciliated	JJ
cord-296585-yfh5d4io	42	23	squamous	squamous	JJ
cord-296585-yfh5d4io	42	24	epithelial	epithelial	JJ
cord-296585-yfh5d4io	42	25	cells	cell	NNS
cord-296585-yfh5d4io	42	26	.	.	.
cord-296585-yfh5d4io	43	1	Small	small	JJ
cord-296585-yfh5d4io	43	2	airway	airway	NN
cord-296585-yfh5d4io	43	3	diseases	disease	NNS
cord-296585-yfh5d4io	43	4	,	,	,
cord-296585-yfh5d4io	43	5	on	on	IN
cord-296585-yfh5d4io	43	6	the	the	DT
cord-296585-yfh5d4io	43	7	other	other	JJ
cord-296585-yfh5d4io	43	8	hand	hand	NN
cord-296585-yfh5d4io	43	9	,	,	,
cord-296585-yfh5d4io	43	10	involve	involve	VBP
cord-296585-yfh5d4io	43	11	hyperplasia	hyperplasia	NN
cord-296585-yfh5d4io	43	12	and	and	CC
cord-296585-yfh5d4io	43	13	metaplasia	metaplasia	NN
cord-296585-yfh5d4io	43	14	of	of	IN
cord-296585-yfh5d4io	43	15	mucosal	mucosal	JJ
cord-296585-yfh5d4io	43	16	glands	gland	NNS
cord-296585-yfh5d4io	43	17	and	and	CC
cord-296585-yfh5d4io	43	18	goblet	goblet	NN
cord-296585-yfh5d4io	43	19	cells	cell	NNS
cord-296585-yfh5d4io	43	20	,	,	,
cord-296585-yfh5d4io	43	21	hypersecretion	hypersecretion	NN
cord-296585-yfh5d4io	43	22	of	of	IN
cord-296585-yfh5d4io	43	23	intraluminal	intraluminal	JJ
cord-296585-yfh5d4io	43	24	mucus	mucus	NN
cord-296585-yfh5d4io	43	25	,	,	,
cord-296585-yfh5d4io	43	26	macrophage	macrophage	NN
cord-296585-yfh5d4io	43	27	bronchiolitis	bronchiolitis	NN
cord-296585-yfh5d4io	43	28	,	,	,
cord-296585-yfh5d4io	43	29	and	and	CC
cord-296585-yfh5d4io	43	30	accumulation	accumulation	NN
cord-296585-yfh5d4io	43	31	of	of	IN
cord-296585-yfh5d4io	43	32	lymphocytes	lymphocyte	NNS
cord-296585-yfh5d4io	43	33	in	in	IN
cord-296585-yfh5d4io	43	34	the	the	DT
cord-296585-yfh5d4io	43	35	small	small	JJ
cord-296585-yfh5d4io	43	36	bronchioles	bronchiole	NNS
cord-296585-yfh5d4io	43	37	(	(	-LRB-
cord-296585-yfh5d4io	43	38	airways	airways	NNP
cord-296585-yfh5d4io	43	39	of	of	IN
cord-296585-yfh5d4io	43	40	∼2	∼2	NNP
cord-296585-yfh5d4io	43	41	mm	mm	NNP
cord-296585-yfh5d4io	43	42	or	or	CC
cord-296585-yfh5d4io	43	43	less	less	JJR
cord-296585-yfh5d4io	43	44	in	in	IN
cord-296585-yfh5d4io	43	45	diameter	diameter	NN
cord-296585-yfh5d4io	43	46	and	and	CC
cord-296585-yfh5d4io	43	47	terminal	terminal	JJ
cord-296585-yfh5d4io	43	48	bronchioles	bronchiole	NNS
cord-296585-yfh5d4io	43	49	)	)	-RRB-
cord-296585-yfh5d4io	43	50	.	.	.
cord-296585-yfh5d4io	44	1	In	in	IN
cord-296585-yfh5d4io	44	2	addition	addition	NN
cord-296585-yfh5d4io	44	3	,	,	,
cord-296585-yfh5d4io	44	4	distortion	distortion	NN
cord-296585-yfh5d4io	44	5	,	,	,
cord-296585-yfh5d4io	44	6	fibrosis	fibrosis	NN
cord-296585-yfh5d4io	44	7	,	,	,
cord-296585-yfh5d4io	44	8	stenosis	stenosis	NN
cord-296585-yfh5d4io	44	9	,	,	,
cord-296585-yfh5d4io	44	10	tortuosities	tortuosity	NNS
cord-296585-yfh5d4io	44	11	,	,	,
cord-296585-yfh5d4io	44	12	hyperplasia	hyperplasia	NN
cord-296585-yfh5d4io	44	13	,	,	,
cord-296585-yfh5d4io	44	14	and	and	CC
cord-296585-yfh5d4io	44	15	hypertrophia	hypertrophia	NNP
cord-296585-yfh5d4io	44	16	of	of	IN
cord-296585-yfh5d4io	44	17	the	the	DT
cord-296585-yfh5d4io	44	18	small	small	JJ
cord-296585-yfh5d4io	44	19	airway	airway	NN
cord-296585-yfh5d4io	44	20	smooth	smooth	JJ
cord-296585-yfh5d4io	44	21	muscles	muscle	NNS
cord-296585-yfh5d4io	44	22	also	also	RB
cord-296585-yfh5d4io	44	23	contribute	contribute	VBP
cord-296585-yfh5d4io	44	24	to	to	IN
cord-296585-yfh5d4io	44	25	the	the	DT
cord-296585-yfh5d4io	44	26	loss	loss	NN
cord-296585-yfh5d4io	44	27	of	of	IN
cord-296585-yfh5d4io	44	28	elasticity	elasticity	NN
cord-296585-yfh5d4io	44	29	in	in	IN
cord-296585-yfh5d4io	44	30	the	the	DT
cord-296585-yfh5d4io	44	31	lung	lung	NN
cord-296585-yfh5d4io	44	32	parenchyma	parenchyma	NN
cord-296585-yfh5d4io	44	33	.	.	.
cord-296585-yfh5d4io	45	1	Although	although	IN
cord-296585-yfh5d4io	45	2	COPD	COPD	NNP
cord-296585-yfh5d4io	45	3	mainly	mainly	RB
cord-296585-yfh5d4io	45	4	affects	affect	VBZ
cord-296585-yfh5d4io	45	5	the	the	DT
cord-296585-yfh5d4io	45	6	lungs	lung	NNS
cord-296585-yfh5d4io	45	7	,	,	,
cord-296585-yfh5d4io	45	8	it	-PRON-	PRP
cord-296585-yfh5d4io	45	9	also	also	RB
cord-296585-yfh5d4io	45	10	produces	produce	VBZ
cord-296585-yfh5d4io	45	11	significant	significant	JJ
cord-296585-yfh5d4io	45	12	extrapulmonary	extrapulmonary	JJ
cord-296585-yfh5d4io	45	13	consequences	consequence	NNS
cord-296585-yfh5d4io	45	14	as	as	IN
cord-296585-yfh5d4io	45	15	a	a	DT
cord-296585-yfh5d4io	45	16	results	result	NNS
cord-296585-yfh5d4io	45	17	of	of	IN
cord-296585-yfh5d4io	45	18	an	an	DT
cord-296585-yfh5d4io	45	19	escalated	escalate	VBN
cord-296585-yfh5d4io	45	20	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	45	21	response	response	NN
cord-296585-yfh5d4io	45	22	orchestrated	orchestrate	VBN
cord-296585-yfh5d4io	45	23	by	by	IN
cord-296585-yfh5d4io	45	24	airway	airway	NN
cord-296585-yfh5d4io	45	25	cells	cell	NNS
cord-296585-yfh5d4io	45	26	and	and	CC
cord-296585-yfh5d4io	45	27	immune	immune	JJ
cord-296585-yfh5d4io	45	28	mediators	mediator	NNS
cord-296585-yfh5d4io	45	29	(	(	-LRB-
cord-296585-yfh5d4io	45	30	20	20	CD
cord-296585-yfh5d4io	45	31	,	,	,
cord-296585-yfh5d4io	45	32	21	21	CD
cord-296585-yfh5d4io	45	33	)	)	-RRB-
cord-296585-yfh5d4io	45	34	.	.	.
cord-296585-yfh5d4io	46	1	The	the	DT
cord-296585-yfh5d4io	46	2	comorbidities	comorbiditie	NNS
cord-296585-yfh5d4io	46	3	are	be	VBP
cord-296585-yfh5d4io	46	4	commonly	commonly	RB
cord-296585-yfh5d4io	46	5	seen	see	VBN
cord-296585-yfh5d4io	46	6	in	in	IN
cord-296585-yfh5d4io	46	7	COPD	COPD	NNP
cord-296585-yfh5d4io	46	8	patients	patient	NNS
cord-296585-yfh5d4io	46	9	despite	despite	IN
cord-296585-yfh5d4io	46	10	the	the	DT
cord-296585-yfh5d4io	46	11	actual	actual	JJ
cord-296585-yfh5d4io	46	12	mechanism	mechanism	NN
cord-296585-yfh5d4io	46	13	responsible	responsible	JJ
cord-296585-yfh5d4io	46	14	for	for	IN
cord-296585-yfh5d4io	46	15	the	the	DT
cord-296585-yfh5d4io	46	16	systemic	systemic	JJ
cord-296585-yfh5d4io	46	17	inflammation	inflammation	NN
cord-296585-yfh5d4io	46	18	remains	remain	VBZ
cord-296585-yfh5d4io	46	19	to	to	TO
cord-296585-yfh5d4io	46	20	be	be	VB
cord-296585-yfh5d4io	46	21	elucidated	elucidate	VBN
cord-296585-yfh5d4io	46	22	.	.	.
cord-296585-yfh5d4io	47	1	The	the	DT
cord-296585-yfh5d4io	47	2	development	development	NN
cord-296585-yfh5d4io	47	3	of	of	IN
cord-296585-yfh5d4io	47	4	COPD	COPD	NNP
cord-296585-yfh5d4io	47	5	is	be	VBZ
cord-296585-yfh5d4io	47	6	multifactorial	multifactorial	JJ
cord-296585-yfh5d4io	47	7	,	,	,
cord-296585-yfh5d4io	47	8	with	with	IN
cord-296585-yfh5d4io	47	9	cigarette	cigarette	NN
cord-296585-yfh5d4io	47	10	or	or	CC
cord-296585-yfh5d4io	47	11	tobacco	tobacco	NN
cord-296585-yfh5d4io	47	12	smoking	smoking	NN
cord-296585-yfh5d4io	47	13	being	be	VBG
cord-296585-yfh5d4io	47	14	the	the	DT
cord-296585-yfh5d4io	47	15	primary	primary	JJ
cord-296585-yfh5d4io	47	16	cause	cause	NN
cord-296585-yfh5d4io	47	17	of	of	IN
cord-296585-yfh5d4io	47	18	COPD	COPD	NNP
cord-296585-yfh5d4io	47	19	(	(	-LRB-
cord-296585-yfh5d4io	47	20	22	22	CD
cord-296585-yfh5d4io	47	21	,	,	,
cord-296585-yfh5d4io	47	22	23	23	CD
cord-296585-yfh5d4io	47	23	)	)	-RRB-
cord-296585-yfh5d4io	47	24	.	.	.
cord-296585-yfh5d4io	48	1	Other	other	JJ
cord-296585-yfh5d4io	48	2	risk	risk	NN
cord-296585-yfh5d4io	48	3	factors	factor	NNS
cord-296585-yfh5d4io	48	4	that	that	WDT
cord-296585-yfh5d4io	48	5	may	may	MD
cord-296585-yfh5d4io	48	6	promote	promote	VB
cord-296585-yfh5d4io	48	7	the	the	DT
cord-296585-yfh5d4io	48	8	onset	onset	NN
cord-296585-yfh5d4io	48	9	and	and	CC
cord-296585-yfh5d4io	48	10	progression	progression	NN
cord-296585-yfh5d4io	48	11	of	of	IN
cord-296585-yfh5d4io	48	12	COPD	COPD	NNP
cord-296585-yfh5d4io	48	13	includes	include	VBZ
cord-296585-yfh5d4io	48	14	prolonged	prolong	VBN
cord-296585-yfh5d4io	48	15	occupational	occupational	JJ
cord-296585-yfh5d4io	48	16	exposure	exposure	NN
cord-296585-yfh5d4io	48	17	to	to	IN
cord-296585-yfh5d4io	48	18	particles	particle	NNS
cord-296585-yfh5d4io	48	19	/	/	SYM
cord-296585-yfh5d4io	48	20	gases	gas	NNS
cord-296585-yfh5d4io	48	21	in	in	IN
cord-296585-yfh5d4io	48	22	mining	mining	NN
cord-296585-yfh5d4io	48	23	and	and	CC
cord-296585-yfh5d4io	48	24	textile	textile	NN
cord-296585-yfh5d4io	48	25	industries	industry	NNS
cord-296585-yfh5d4io	48	26	,	,	,
cord-296585-yfh5d4io	48	27	air	air	NN
cord-296585-yfh5d4io	48	28	pollution	pollution	NN
cord-296585-yfh5d4io	48	29	resulting	result	VBG
cord-296585-yfh5d4io	48	30	from	from	IN
cord-296585-yfh5d4io	48	31	biomass	biomass	NN
cord-296585-yfh5d4io	48	32	combustion	combustion	NN
cord-296585-yfh5d4io	48	33	,	,	,
cord-296585-yfh5d4io	48	34	and	and	CC
cord-296585-yfh5d4io	48	35	bronchial	bronchial	JJ
cord-296585-yfh5d4io	48	36	hyperresponsiveness	hyperresponsiveness	NN
cord-296585-yfh5d4io	48	37	(	(	-LRB-
cord-296585-yfh5d4io	48	38	16	16	CD
cord-296585-yfh5d4io	48	39	,	,	,
cord-296585-yfh5d4io	48	40	18	18	CD
cord-296585-yfh5d4io	48	41	,	,	,
cord-296585-yfh5d4io	48	42	24	24	CD
cord-296585-yfh5d4io	48	43	)	)	-RRB-
cord-296585-yfh5d4io	48	44	.	.	.
cord-296585-yfh5d4io	49	1	The	the	DT
cord-296585-yfh5d4io	49	2	variability	variability	NN
cord-296585-yfh5d4io	49	3	of	of	IN
cord-296585-yfh5d4io	49	4	COPD	COPD	NNP
cord-296585-yfh5d4io	49	5	incidences	incidence	NNS
cord-296585-yfh5d4io	49	6	among	among	IN
cord-296585-yfh5d4io	49	7	smokers	smoker	NNS
cord-296585-yfh5d4io	49	8	is	be	VBZ
cord-296585-yfh5d4io	49	9	also	also	RB
cord-296585-yfh5d4io	49	10	explained	explain	VBN
cord-296585-yfh5d4io	49	11	by	by	IN
cord-296585-yfh5d4io	49	12	a	a	DT
cord-296585-yfh5d4io	49	13	genetic	genetic	JJ
cord-296585-yfh5d4io	49	14	predisposition	predisposition	NN
cord-296585-yfh5d4io	49	15	,	,	,
cord-296585-yfh5d4io	49	16	such	such	JJ
cord-296585-yfh5d4io	49	17	as	as	IN
cord-296585-yfh5d4io	49	18	α1-antitrypsin	α1-antitrypsin	NNP
cord-296585-yfh5d4io	49	19	deficiency	deficiency	NN
cord-296585-yfh5d4io	49	20	and	and	CC
cord-296585-yfh5d4io	49	21	cutis	cutis	NNP
cord-296585-yfh5d4io	49	22	laxa	laxa	NNP
cord-296585-yfh5d4io	49	23	[	[	-LRB-
cord-296585-yfh5d4io	49	24	mutation	mutation	NN
cord-296585-yfh5d4io	49	25	of	of	IN
cord-296585-yfh5d4io	49	26	the	the	DT
cord-296585-yfh5d4io	49	27	elastin	elastin	NN
cord-296585-yfh5d4io	49	28	gene	gene	NN
cord-296585-yfh5d4io	49	29	(	(	-LRB-
cord-296585-yfh5d4io	49	30	ELN	ELN	NNP
cord-296585-yfh5d4io	49	31	)	)	-RRB-
cord-296585-yfh5d4io	49	32	]	]	-RRB-
cord-296585-yfh5d4io	49	33	(	(	-LRB-
cord-296585-yfh5d4io	49	34	25	25	CD
cord-296585-yfh5d4io	49	35	,	,	,
cord-296585-yfh5d4io	49	36	26	26	CD
cord-296585-yfh5d4io	49	37	)	)	-RRB-
cord-296585-yfh5d4io	49	38	.	.	.
cord-296585-yfh5d4io	50	1	The	the	DT
cord-296585-yfh5d4io	50	2	α1-antitrypsin	α1-antitrypsin	NNP
cord-296585-yfh5d4io	50	3	deficiency	deficiency	NN
cord-296585-yfh5d4io	50	4	is	be	VBZ
cord-296585-yfh5d4io	50	5	caused	cause	VBN
cord-296585-yfh5d4io	50	6	by	by	IN
cord-296585-yfh5d4io	50	7	deleterious	deleterious	JJ
cord-296585-yfh5d4io	50	8	homozygous	homozygous	JJ
cord-296585-yfh5d4io	50	9	mutations	mutation	NNS
cord-296585-yfh5d4io	50	10	in	in	IN
cord-296585-yfh5d4io	50	11	SERPINA1	SERPINA1	NNS
cord-296585-yfh5d4io	50	12	which	which	WDT
cord-296585-yfh5d4io	50	13	contributes	contribute	VBZ
cord-296585-yfh5d4io	50	14	to	to	IN
cord-296585-yfh5d4io	50	15	1	1	CD
cord-296585-yfh5d4io	50	16	-	-	SYM
cord-296585-yfh5d4io	50	17	2	2	CD
cord-296585-yfh5d4io	50	18	%	%	NN
cord-296585-yfh5d4io	50	19	of	of	IN
cord-296585-yfh5d4io	50	20	COPD	COPD	NNP
cord-296585-yfh5d4io	50	21	cases	case	NNS
cord-296585-yfh5d4io	50	22	.	.	.
cord-296585-yfh5d4io	51	1	The	the	DT
cord-296585-yfh5d4io	51	2	deficiency	deficiency	NN
cord-296585-yfh5d4io	51	3	results	result	VBZ
cord-296585-yfh5d4io	51	4	in	in	IN
cord-296585-yfh5d4io	51	5	increased	increase	VBN
cord-296585-yfh5d4io	51	6	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	51	7	elastase	elastase	NN
cord-296585-yfh5d4io	51	8	activity	activity	NN
cord-296585-yfh5d4io	51	9	that	that	WDT
cord-296585-yfh5d4io	51	10	ultimately	ultimately	RB
cord-296585-yfh5d4io	51	11	leads	lead	VBZ
cord-296585-yfh5d4io	51	12	to	to	IN
cord-296585-yfh5d4io	51	13	the	the	DT
cord-296585-yfh5d4io	51	14	degradation	degradation	NN
cord-296585-yfh5d4io	51	15	and	and	CC
cord-296585-yfh5d4io	51	16	collapse	collapse	NN
cord-296585-yfh5d4io	51	17	of	of	IN
cord-296585-yfh5d4io	51	18	the	the	DT
cord-296585-yfh5d4io	51	19	alveoli	alveolus	NNS
cord-296585-yfh5d4io	51	20	.	.	.
cord-296585-yfh5d4io	52	1	Importantly	importantly	RB
cord-296585-yfh5d4io	52	2	,	,	,
cord-296585-yfh5d4io	52	3	meta	meta	NNP
cord-296585-yfh5d4io	52	4	-	-	HYPH
cord-296585-yfh5d4io	52	5	analyses	analysis	NNS
cord-296585-yfh5d4io	52	6	of	of	IN
cord-296585-yfh5d4io	52	7	genome	genome	NN
cord-296585-yfh5d4io	52	8	-	-	HYPH
cord-296585-yfh5d4io	52	9	wide	wide	JJ
cord-296585-yfh5d4io	52	10	association	association	NN
cord-296585-yfh5d4io	52	11	studies	study	NNS
cord-296585-yfh5d4io	52	12	(	(	-LRB-
cord-296585-yfh5d4io	52	13	GWAS	GWAS	NNP
cord-296585-yfh5d4io	52	14	)	)	-RRB-
cord-296585-yfh5d4io	52	15	and	and	CC
cord-296585-yfh5d4io	52	16	other	other	JJ
cord-296585-yfh5d4io	52	17	genotyping	genotyping	NN
cord-296585-yfh5d4io	52	18	studies	study	NNS
cord-296585-yfh5d4io	52	19	have	have	VBP
cord-296585-yfh5d4io	52	20	revealed	reveal	VBN
cord-296585-yfh5d4io	52	21	that	that	IN
cord-296585-yfh5d4io	52	22	multiple	multiple	JJ
cord-296585-yfh5d4io	52	23	single	single	JJ
cord-296585-yfh5d4io	52	24	nucleotide	nucleotide	JJ
cord-296585-yfh5d4io	52	25	polymorphism	polymorphism	NN
cord-296585-yfh5d4io	52	26	(	(	-LRB-
cord-296585-yfh5d4io	52	27	SNPs	SNPs	NNP
cord-296585-yfh5d4io	52	28	)	)	-RRB-
cord-296585-yfh5d4io	52	29	in	in	IN
cord-296585-yfh5d4io	52	30	at	at	RB
cord-296585-yfh5d4io	52	31	least	least	RBS
cord-296585-yfh5d4io	52	32	34	34	CD
cord-296585-yfh5d4io	52	33	genes	gene	NNS
cord-296585-yfh5d4io	52	34	from	from	IN
cord-296585-yfh5d4io	52	35	different	different	JJ
cord-296585-yfh5d4io	52	36	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	52	37	genomic	genomic	JJ
cord-296585-yfh5d4io	52	38	loci	locus	NNS
cord-296585-yfh5d4io	52	39	are	be	VBP
cord-296585-yfh5d4io	52	40	associated	associate	VBN
cord-296585-yfh5d4io	52	41	with	with	IN
cord-296585-yfh5d4io	52	42	COPD	COPD	NNP
cord-296585-yfh5d4io	52	43	susceptibility	susceptibility	NN
cord-296585-yfh5d4io	52	44	(	(	-LRB-
cord-296585-yfh5d4io	52	45	27	27	CD
cord-296585-yfh5d4io	52	46	)	)	-RRB-
cord-296585-yfh5d4io	52	47	(	(	-LRB-
cord-296585-yfh5d4io	52	48	28	28	CD
cord-296585-yfh5d4io	52	49	)	)	-RRB-
cord-296585-yfh5d4io	52	50	(	(	-LRB-
cord-296585-yfh5d4io	52	51	29	29	CD
cord-296585-yfh5d4io	52	52	)	)	-RRB-
cord-296585-yfh5d4io	52	53	(	(	-LRB-
cord-296585-yfh5d4io	52	54	30	30	CD
cord-296585-yfh5d4io	52	55	)	)	-RRB-
cord-296585-yfh5d4io	52	56	.	.	.
cord-296585-yfh5d4io	53	1	Airway	airway	NN
cord-296585-yfh5d4io	53	2	epithelium	epithelium	NN
cord-296585-yfh5d4io	53	3	exposed	expose	VBN
cord-296585-yfh5d4io	53	4	to	to	IN
cord-296585-yfh5d4io	53	5	cigarette	cigarette	NN
cord-296585-yfh5d4io	53	6	or	or	CC
cord-296585-yfh5d4io	53	7	tobacco	tobacco	NN
cord-296585-yfh5d4io	53	8	smoke	smoke	NN
cord-296585-yfh5d4io	53	9	has	have	VBZ
cord-296585-yfh5d4io	53	10	compromised	compromise	VBN
cord-296585-yfh5d4io	53	11	tight	tight	JJ
cord-296585-yfh5d4io	53	12	junctions	junction	NNS
cord-296585-yfh5d4io	53	13	and	and	CC
cord-296585-yfh5d4io	53	14	delayed	delay	VBN
cord-296585-yfh5d4io	53	15	epithelial	epithelial	JJ
cord-296585-yfh5d4io	53	16	wound	wound	NN
cord-296585-yfh5d4io	53	17	repair	repair	NN
cord-296585-yfh5d4io	53	18	(	(	-LRB-
cord-296585-yfh5d4io	53	19	31	31	CD
cord-296585-yfh5d4io	53	20	)	)	-RRB-
cord-296585-yfh5d4io	53	21	(	(	-LRB-
cord-296585-yfh5d4io	53	22	32	32	CD
cord-296585-yfh5d4io	53	23	)	)	-RRB-
cord-296585-yfh5d4io	53	24	(	(	-LRB-
cord-296585-yfh5d4io	53	25	33	33	CD
cord-296585-yfh5d4io	53	26	)	)	-RRB-
cord-296585-yfh5d4io	53	27	(	(	-LRB-
cord-296585-yfh5d4io	53	28	34	34	CD
cord-296585-yfh5d4io	53	29	)	)	-RRB-
cord-296585-yfh5d4io	53	30	.	.	.
cord-296585-yfh5d4io	54	1	Moreover	moreover	RB
cord-296585-yfh5d4io	54	2	,	,	,
cord-296585-yfh5d4io	54	3	cigarette	cigarette	NN
cord-296585-yfh5d4io	54	4	smoke	smoke	NN
cord-296585-yfh5d4io	54	5	alters	alter	VBZ
cord-296585-yfh5d4io	54	6	basal	basal	JJ
cord-296585-yfh5d4io	54	7	cell	cell	NN
cord-296585-yfh5d4io	54	8	differentiation	differentiation	NN
cord-296585-yfh5d4io	54	9	and	and	CC
cord-296585-yfh5d4io	54	10	subepithelial	subepithelial	JJ
cord-296585-yfh5d4io	54	11	extracellular	extracellular	JJ
cord-296585-yfh5d4io	54	12	matrix	matrix	NN
cord-296585-yfh5d4io	54	13	(	(	-LRB-
cord-296585-yfh5d4io	54	14	ECM	ECM	NNP
cord-296585-yfh5d4io	54	15	)	)	-RRB-
cord-296585-yfh5d4io	54	16	composition	composition	NN
cord-296585-yfh5d4io	54	17	,	,	,
cord-296585-yfh5d4io	54	18	and	and	CC
cord-296585-yfh5d4io	54	19	thus	thus	RB
cord-296585-yfh5d4io	54	20	causes	cause	VBZ
cord-296585-yfh5d4io	54	21	airway	airway	NN
cord-296585-yfh5d4io	54	22	remodeling	remodeling	NN
cord-296585-yfh5d4io	54	23	(	(	-LRB-
cord-296585-yfh5d4io	54	24	i.e.	i.e.	FW
cord-296585-yfh5d4io	54	25	,	,	,
cord-296585-yfh5d4io	54	26	goblet	goblet	NN
cord-296585-yfh5d4io	54	27	cell	cell	NN
cord-296585-yfh5d4io	54	28	hyperplasia	hyperplasia	NN
cord-296585-yfh5d4io	54	29	and	and	CC
cord-296585-yfh5d4io	54	30	small	small	JJ
cord-296585-yfh5d4io	54	31	airway	airway	NN
cord-296585-yfh5d4io	54	32	squamous	squamous	JJ
cord-296585-yfh5d4io	54	33	metaplasia	metaplasia	NN
cord-296585-yfh5d4io	54	34	)	)	-RRB-
cord-296585-yfh5d4io	54	35	(	(	-LRB-
cord-296585-yfh5d4io	54	36	35	35	CD
cord-296585-yfh5d4io	54	37	)	)	-RRB-
cord-296585-yfh5d4io	54	38	(	(	-LRB-
cord-296585-yfh5d4io	54	39	36	36	CD
cord-296585-yfh5d4io	54	40	)	)	-RRB-
cord-296585-yfh5d4io	54	41	(	(	-LRB-
cord-296585-yfh5d4io	54	42	37	37	CD
cord-296585-yfh5d4io	54	43	)	)	-RRB-
cord-296585-yfh5d4io	54	44	.	.	.
cord-296585-yfh5d4io	55	1	This	this	DT
cord-296585-yfh5d4io	55	2	results	result	VBZ
cord-296585-yfh5d4io	55	3	in	in	IN
cord-296585-yfh5d4io	55	4	mucus	mucus	NN
cord-296585-yfh5d4io	55	5	hypersecretion	hypersecretion	NN
cord-296585-yfh5d4io	55	6	,	,	,
cord-296585-yfh5d4io	55	7	impaired	impair	VBN
cord-296585-yfh5d4io	55	8	mucocilliary	mucocilliary	JJ
cord-296585-yfh5d4io	55	9	clearance	clearance	NN
cord-296585-yfh5d4io	55	10	,	,	,
cord-296585-yfh5d4io	55	11	and	and	CC
cord-296585-yfh5d4io	55	12	airway	airway	NN
cord-296585-yfh5d4io	55	13	obstruction	obstruction	NN
cord-296585-yfh5d4io	55	14	.	.	.
cord-296585-yfh5d4io	56	1	Tobacco	tobacco	NN
cord-296585-yfh5d4io	56	2	or	or	CC
cord-296585-yfh5d4io	56	3	cigarette	cigarette	NN
cord-296585-yfh5d4io	56	4	smoke	smoke	NN
cord-296585-yfh5d4io	56	5	also	also	RB
cord-296585-yfh5d4io	56	6	enhances	enhance	VBZ
cord-296585-yfh5d4io	56	7	proliferation	proliferation	NN
cord-296585-yfh5d4io	56	8	and	and	CC
cord-296585-yfh5d4io	56	9	ECM	ECM	NNP
cord-296585-yfh5d4io	56	10	deposition	deposition	NN
cord-296585-yfh5d4io	56	11	by	by	IN
cord-296585-yfh5d4io	56	12	activating	activate	VBG
cord-296585-yfh5d4io	56	13	the	the	DT
cord-296585-yfh5d4io	56	14	extracellular	extracellular	JJ
cord-296585-yfh5d4io	56	15	signal	signal	NN
cord-296585-yfh5d4io	56	16	related	relate	VBN
cord-296585-yfh5d4io	56	17	kinase	kinase	NN
cord-296585-yfh5d4io	56	18	(	(	-LRB-
cord-296585-yfh5d4io	56	19	ERK	ERK	NNP
cord-296585-yfh5d4io	56	20	)	)	-RRB-
cord-296585-yfh5d4io	56	21	and	and	CC
cord-296585-yfh5d4io	56	22	the	the	DT
cord-296585-yfh5d4io	56	23	p38	p38	NNP
cord-296585-yfh5d4io	56	24	signaling	signal	VBG
cord-296585-yfh5d4io	56	25	pathway	pathway	NN
cord-296585-yfh5d4io	56	26	(	(	-LRB-
cord-296585-yfh5d4io	56	27	38	38	CD
cord-296585-yfh5d4io	56	28	)	)	-RRB-
cord-296585-yfh5d4io	56	29	.	.	.
cord-296585-yfh5d4io	57	1	The	the	DT
cord-296585-yfh5d4io	57	2	alteration	alteration	NN
cord-296585-yfh5d4io	57	3	of	of	IN
cord-296585-yfh5d4io	57	4	major	major	JJ
cord-296585-yfh5d4io	57	5	ECM	ECM	NNP
cord-296585-yfh5d4io	57	6	components	component	NNS
cord-296585-yfh5d4io	57	7	are	be	VBP
cord-296585-yfh5d4io	57	8	widespread	widespread	JJ
cord-296585-yfh5d4io	57	9	in	in	IN
cord-296585-yfh5d4io	57	10	all	all	DT
cord-296585-yfh5d4io	57	11	lung	lung	NN
cord-296585-yfh5d4io	57	12	compartments	compartment	NNS
cord-296585-yfh5d4io	57	13	in	in	IN
cord-296585-yfh5d4io	57	14	COPD	COPD	NNP
cord-296585-yfh5d4io	57	15	patients	patient	NNS
cord-296585-yfh5d4io	57	16	with	with	IN
cord-296585-yfh5d4io	57	17	a	a	DT
cord-296585-yfh5d4io	57	18	total	total	JJ
cord-296585-yfh5d4io	57	19	increase	increase	NN
cord-296585-yfh5d4io	57	20	of	of	IN
cord-296585-yfh5d4io	57	21	type	type	NN
cord-296585-yfh5d4io	57	22	I	-PRON-	PRP
cord-296585-yfh5d4io	57	23	and	and	CC
cord-296585-yfh5d4io	57	24	III	iii	CD
cord-296585-yfh5d4io	57	25	collagens	collagen	NNS
cord-296585-yfh5d4io	57	26	,	,	,
cord-296585-yfh5d4io	57	27	fibronectin	fibronectin	NN
cord-296585-yfh5d4io	57	28	,	,	,
cord-296585-yfh5d4io	57	29	and	and	CC
cord-296585-yfh5d4io	57	30	laminin	laminin	NN
cord-296585-yfh5d4io	57	31	in	in	IN
cord-296585-yfh5d4io	57	32	parallel	parallel	NN
cord-296585-yfh5d4io	57	33	with	with	IN
cord-296585-yfh5d4io	57	34	reduced	reduce	VBN
cord-296585-yfh5d4io	57	35	concentrations	concentration	NNS
cord-296585-yfh5d4io	57	36	of	of	IN
cord-296585-yfh5d4io	57	37	proteoglycans	proteoglycan	NNS
cord-296585-yfh5d4io	57	38	,	,	,
cord-296585-yfh5d4io	57	39	perlecan	perlecan	NNP
cord-296585-yfh5d4io	57	40	decorin	decorin	NNP
cord-296585-yfh5d4io	57	41	,	,	,
cord-296585-yfh5d4io	57	42	versican	versican	NNP
cord-296585-yfh5d4io	57	43	,	,	,
cord-296585-yfh5d4io	57	44	biglycan	biglycan	NNP
cord-296585-yfh5d4io	57	45	,	,	,
cord-296585-yfh5d4io	57	46	tenascin	tenascin	NNP
cord-296585-yfh5d4io	57	47	and	and	CC
cord-296585-yfh5d4io	57	48	elastin	elastin	NN
cord-296585-yfh5d4io	57	49	(	(	-LRB-
cord-296585-yfh5d4io	57	50	39	39	CD
cord-296585-yfh5d4io	57	51	,	,	,
cord-296585-yfh5d4io	57	52	40	40	CD
cord-296585-yfh5d4io	57	53	)	)	-RRB-
cord-296585-yfh5d4io	57	54	.	.	.
cord-296585-yfh5d4io	58	1	Cigarette	cigarette	NN
cord-296585-yfh5d4io	58	2	induced	induced	NN
cord-296585-yfh5d4io	58	3	-	-	HYPH
cord-296585-yfh5d4io	58	4	overexpression	overexpression	NN
cord-296585-yfh5d4io	58	5	of	of	IN
cord-296585-yfh5d4io	58	6	matrix	matrix	NN
cord-296585-yfh5d4io	58	7	metalloproteases	metalloprotease	NNS
cord-296585-yfh5d4io	59	1	(	(	-LRB-
cord-296585-yfh5d4io	59	2	MMPs-	MMPs-	NNP
cord-296585-yfh5d4io	59	3	1	1	CD
cord-296585-yfh5d4io	59	4	,	,	,
cord-296585-yfh5d4io	59	5	2	2	CD
cord-296585-yfh5d4io	59	6	,	,	,
cord-296585-yfh5d4io	59	7	7	7	CD
cord-296585-yfh5d4io	59	8	,	,	,
cord-296585-yfh5d4io	59	9	9	9	CD
cord-296585-yfh5d4io	59	10	,	,	,
cord-296585-yfh5d4io	59	11	12	12	CD
cord-296585-yfh5d4io	59	12	,	,	,
cord-296585-yfh5d4io	59	13	and	and	CC
cord-296585-yfh5d4io	59	14	28	28	CD
cord-296585-yfh5d4io	59	15	)	)	-RRB-
cord-296585-yfh5d4io	59	16	and	and	CC
cord-296585-yfh5d4io	59	17	elastase	elastase	NN
cord-296585-yfh5d4io	59	18	has	have	VBZ
cord-296585-yfh5d4io	59	19	also	also	RB
cord-296585-yfh5d4io	59	20	been	be	VBN
cord-296585-yfh5d4io	59	21	reported	report	VBN
cord-296585-yfh5d4io	59	22	,	,	,
cord-296585-yfh5d4io	59	23	and	and	CC
cord-296585-yfh5d4io	59	24	may	may	MD
cord-296585-yfh5d4io	59	25	contribute	contribute	VB
cord-296585-yfh5d4io	59	26	to	to	IN
cord-296585-yfh5d4io	59	27	the	the	DT
cord-296585-yfh5d4io	59	28	airway	airway	NN
cord-296585-yfh5d4io	59	29	tissue	tissue	NN
cord-296585-yfh5d4io	59	30	destruction	destruction	NN
cord-296585-yfh5d4io	59	31	and	and	CC
cord-296585-yfh5d4io	59	32	fibrosis	fibrosis	NN
cord-296585-yfh5d4io	59	33	(	(	-LRB-
cord-296585-yfh5d4io	59	34	41	41	CD
cord-296585-yfh5d4io	59	35	-	-	SYM
cord-296585-yfh5d4io	59	36	43	43	CD
cord-296585-yfh5d4io	59	37	)	)	-RRB-
cord-296585-yfh5d4io	59	38	.	.	.
cord-296585-yfh5d4io	60	1	In	in	IN
cord-296585-yfh5d4io	60	2	addition	addition	NN
cord-296585-yfh5d4io	60	3	,	,	,
cord-296585-yfh5d4io	60	4	harmful	harmful	JJ
cord-296585-yfh5d4io	60	5	volatile	volatile	JJ
cord-296585-yfh5d4io	60	6	chemicals	chemical	NNS
cord-296585-yfh5d4io	60	7	derived	derive	VBN
cord-296585-yfh5d4io	60	8	from	from	IN
cord-296585-yfh5d4io	60	9	cigarette	cigarette	NN
cord-296585-yfh5d4io	60	10	smoke	smoke	NN
cord-296585-yfh5d4io	60	11	(	(	-LRB-
cord-296585-yfh5d4io	60	12	i.e.	i.e.	FW
cord-296585-yfh5d4io	60	13	,	,	,
cord-296585-yfh5d4io	60	14	acetaldehyde	acetaldehyde	NN
cord-296585-yfh5d4io	60	15	,	,	,
cord-296585-yfh5d4io	60	16	acrolein	acrolein	NN
cord-296585-yfh5d4io	60	17	,	,	,
cord-296585-yfh5d4io	60	18	and	and	CC
cord-296585-yfh5d4io	60	19	crotonaldehyde	crotonaldehyde	NNP
cord-296585-yfh5d4io	60	20	)	)	-RRB-
cord-296585-yfh5d4io	60	21	are	be	VBP
cord-296585-yfh5d4io	60	22	prone	prone	JJ
cord-296585-yfh5d4io	60	23	to	to	TO
cord-296585-yfh5d4io	60	24	form	form	VB
cord-296585-yfh5d4io	60	25	carcinogen	carcinogen	NN
cord-296585-yfh5d4io	60	26	adducts	adduct	NNS
cord-296585-yfh5d4io	60	27	with	with	IN
cord-296585-yfh5d4io	60	28	DNA	dna	NN
cord-296585-yfh5d4io	60	29	and	and	CC
cord-296585-yfh5d4io	60	30	various	various	JJ
cord-296585-yfh5d4io	60	31	proteins	protein	NNS
cord-296585-yfh5d4io	60	32	(	(	-LRB-
cord-296585-yfh5d4io	60	33	i.e.	i.e.	FW
cord-296585-yfh5d4io	60	34	,	,	,
cord-296585-yfh5d4io	60	35	apoliprotein	apoliprotein	NNP
cord-296585-yfh5d4io	60	36	E	E	NNP
cord-296585-yfh5d4io	60	37	and	and	CC
cord-296585-yfh5d4io	60	38	surfactant	surfactant	NN
cord-296585-yfh5d4io	60	39	protein	protein	NN
cord-296585-yfh5d4io	60	40	A	A	NNP
cord-296585-yfh5d4io	60	41	)	)	-RRB-
cord-296585-yfh5d4io	60	42	.	.	.
cord-296585-yfh5d4io	61	1	They	-PRON-	PRP
cord-296585-yfh5d4io	61	2	also	also	RB
cord-296585-yfh5d4io	61	3	dysregulate	dysregulate	VBP
cord-296585-yfh5d4io	61	4	airway	airway	NN
cord-296585-yfh5d4io	61	5	epithelial	epithelial	JJ
cord-296585-yfh5d4io	61	6	ion	ion	NN
cord-296585-yfh5d4io	61	7	transport	transport	NN
cord-296585-yfh5d4io	61	8	,	,	,
cord-296585-yfh5d4io	61	9	disrupt	disrupt	VB
cord-296585-yfh5d4io	61	10	the	the	DT
cord-296585-yfh5d4io	61	11	phagocytic	phagocytic	JJ
cord-296585-yfh5d4io	61	12	activity	activity	NN
cord-296585-yfh5d4io	61	13	of	of	IN
cord-296585-yfh5d4io	61	14	airway	airway	NN
cord-296585-yfh5d4io	61	15	phagocytes	phagocyte	NNS
cord-296585-yfh5d4io	61	16	,	,	,
cord-296585-yfh5d4io	61	17	and	and	CC
cord-296585-yfh5d4io	61	18	diminish	diminish	VB
cord-296585-yfh5d4io	61	19	the	the	DT
cord-296585-yfh5d4io	61	20	airway	airway	NN
cord-296585-yfh5d4io	61	21	surface	surface	NN
cord-296585-yfh5d4io	61	22	liquid	liquid	NN
cord-296585-yfh5d4io	61	23	volume	volume	NN
cord-296585-yfh5d4io	61	24	(	(	-LRB-
cord-296585-yfh5d4io	61	25	44	44	CD
cord-296585-yfh5d4io	61	26	-	-	SYM
cord-296585-yfh5d4io	61	27	46	46	CD
cord-296585-yfh5d4io	61	28	)	)	-RRB-
cord-296585-yfh5d4io	61	29	.	.	.
cord-296585-yfh5d4io	62	1	Numerous	numerous	JJ
cord-296585-yfh5d4io	62	2	proteomics	proteomic	NNS
cord-296585-yfh5d4io	62	3	and	and	CC
cord-296585-yfh5d4io	62	4	transcriptomic	transcriptomic	JJ
cord-296585-yfh5d4io	62	5	analyses	analysis	NNS
cord-296585-yfh5d4io	62	6	have	have	VBP
cord-296585-yfh5d4io	62	7	unveiled	unveil	VBN
cord-296585-yfh5d4io	62	8	the	the	DT
cord-296585-yfh5d4io	62	9	crucial	crucial	JJ
cord-296585-yfh5d4io	62	10	impact	impact	NN
cord-296585-yfh5d4io	62	11	of	of	IN
cord-296585-yfh5d4io	62	12	cigarette	cigarette	NN
cord-296585-yfh5d4io	62	13	or	or	CC
cord-296585-yfh5d4io	62	14	tobacco	tobacco	NN
cord-296585-yfh5d4io	62	15	smoke	smoke	NN
cord-296585-yfh5d4io	62	16	and	and	CC
cord-296585-yfh5d4io	62	17	COPD	COPD	NNP
cord-296585-yfh5d4io	62	18	disease	disease	NN
cord-296585-yfh5d4io	62	19	progression	progression	NN
cord-296585-yfh5d4io	62	20	on	on	IN
cord-296585-yfh5d4io	62	21	airway	airway	NN
cord-296585-yfh5d4io	62	22	gene	gene	NN
cord-296585-yfh5d4io	62	23	expression	expression	NN
cord-296585-yfh5d4io	62	24	(	(	-LRB-
cord-296585-yfh5d4io	62	25	47	47	CD
cord-296585-yfh5d4io	62	26	,	,	,
cord-296585-yfh5d4io	62	27	48	48	CD
cord-296585-yfh5d4io	62	28	)	)	-RRB-
cord-296585-yfh5d4io	62	29	.	.	.
cord-296585-yfh5d4io	63	1	The	the	DT
cord-296585-yfh5d4io	63	2	differential	differential	JJ
cord-296585-yfh5d4io	63	3	gene	gene	NN
cord-296585-yfh5d4io	63	4	expression	expression	NN
cord-296585-yfh5d4io	63	5	studies	study	NNS
cord-296585-yfh5d4io	63	6	were	be	VBD
cord-296585-yfh5d4io	63	7	done	do	VBN
cord-296585-yfh5d4io	63	8	using	use	VBG
cord-296585-yfh5d4io	63	9	COPD	COPD	NNP
cord-296585-yfh5d4io	63	10	experimental	experimental	JJ
cord-296585-yfh5d4io	63	11	models	model	NNS
cord-296585-yfh5d4io	63	12	or	or	CC
cord-296585-yfh5d4io	63	13	clinical	clinical	JJ
cord-296585-yfh5d4io	63	14	samples	sample	NNS
cord-296585-yfh5d4io	63	15	[	[	-LRB-
cord-296585-yfh5d4io	63	16	i.e.	i.e.	FW
cord-296585-yfh5d4io	63	17	,	,	,
cord-296585-yfh5d4io	63	18	bronchial	bronchial	JJ
cord-296585-yfh5d4io	63	19	epithelial	epithelial	JJ
cord-296585-yfh5d4io	63	20	cells	cell	NNS
cord-296585-yfh5d4io	63	21	,	,	,
cord-296585-yfh5d4io	63	22	sputum	sputum	NN
cord-296585-yfh5d4io	63	23	,	,	,
cord-296585-yfh5d4io	63	24	plasma	plasma	NN
cord-296585-yfh5d4io	63	25	,	,	,
cord-296585-yfh5d4io	63	26	blood	blood	NN
cord-296585-yfh5d4io	63	27	,	,	,
cord-296585-yfh5d4io	63	28	and	and	CC
cord-296585-yfh5d4io	63	29	bronchoalveolar	bronchoalveolar	NNP
cord-296585-yfh5d4io	63	30	lavage	lavage	NNP
cord-296585-yfh5d4io	63	31	(	(	-LRB-
cord-296585-yfh5d4io	63	32	BAL	BAL	NNP
cord-296585-yfh5d4io	63	33	)	)	-RRB-
cord-296585-yfh5d4io	63	34	fluid	fluid	NN
cord-296585-yfh5d4io	63	35	]	]	-RRB-
cord-296585-yfh5d4io	63	36	.	.	.
cord-296585-yfh5d4io	64	1	Collectively	collectively	RB
cord-296585-yfh5d4io	64	2	,	,	,
cord-296585-yfh5d4io	64	3	most	most	JJS
cord-296585-yfh5d4io	64	4	of	of	IN
cord-296585-yfh5d4io	64	5	the	the	DT
cord-296585-yfh5d4io	64	6	altered	alter	VBN
cord-296585-yfh5d4io	64	7	genes	gene	NNS
cord-296585-yfh5d4io	64	8	are	be	VBP
cord-296585-yfh5d4io	64	9	involved	involve	VBN
cord-296585-yfh5d4io	64	10	in	in	IN
cord-296585-yfh5d4io	64	11	oxidative	oxidative	JJ
cord-296585-yfh5d4io	64	12	stress	stress	NN
cord-296585-yfh5d4io	64	13	,	,	,
cord-296585-yfh5d4io	64	14	xenobiotic	xenobiotic	JJ
cord-296585-yfh5d4io	64	15	metabolism	metabolism	NN
cord-296585-yfh5d4io	64	16	,	,	,
cord-296585-yfh5d4io	64	17	antioxidant	antioxidant	JJ
cord-296585-yfh5d4io	64	18	responses	response	NNS
cord-296585-yfh5d4io	64	19	,	,	,
cord-296585-yfh5d4io	64	20	DNA	dna	NN
cord-296585-yfh5d4io	64	21	repair	repair	NN
cord-296585-yfh5d4io	64	22	,	,	,
cord-296585-yfh5d4io	64	23	ECM	ECM	NNP
cord-296585-yfh5d4io	64	24	remodeling	remodeling	NN
cord-296585-yfh5d4io	64	25	,	,	,
cord-296585-yfh5d4io	64	26	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	64	27	responses	response	NNS
cord-296585-yfh5d4io	64	28	,	,	,
cord-296585-yfh5d4io	64	29	and	and	CC
cord-296585-yfh5d4io	64	30	immune	immune	JJ
cord-296585-yfh5d4io	64	31	defenses	defense	NNS
cord-296585-yfh5d4io	64	32	,	,	,
cord-296585-yfh5d4io	64	33	which	which	WDT
cord-296585-yfh5d4io	64	34	the	the	DT
cord-296585-yfh5d4io	64	35	latter	latter	JJ
cord-296585-yfh5d4io	64	36	two	two	CD
cord-296585-yfh5d4io	64	37	are	be	VBP
cord-296585-yfh5d4io	64	38	our	-PRON-	PRP$
cord-296585-yfh5d4io	64	39	major	major	JJ
cord-296585-yfh5d4io	64	40	interest	interest	NN
cord-296585-yfh5d4io	64	41	of	of	IN
cord-296585-yfh5d4io	64	42	discussion	discussion	NN
cord-296585-yfh5d4io	64	43	in	in	IN
cord-296585-yfh5d4io	64	44	this	this	DT
cord-296585-yfh5d4io	64	45	review	review	NN
cord-296585-yfh5d4io	64	46	.	.	.
cord-296585-yfh5d4io	65	1	The	the	DT
cord-296585-yfh5d4io	65	2	omics	omic	NNS
cord-296585-yfh5d4io	65	3	data	data	NN
cord-296585-yfh5d4io	65	4	aid	aid	NN
cord-296585-yfh5d4io	65	5	in	in	IN
cord-296585-yfh5d4io	65	6	the	the	DT
cord-296585-yfh5d4io	65	7	increased	increase	VBN
cord-296585-yfh5d4io	65	8	knowledge	knowledge	NN
cord-296585-yfh5d4io	65	9	of	of	IN
cord-296585-yfh5d4io	65	10	molecular	molecular	JJ
cord-296585-yfh5d4io	65	11	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	65	12	in	in	IN
cord-296585-yfh5d4io	65	13	COPD	COPD	NNP
cord-296585-yfh5d4io	65	14	.	.	.
cord-296585-yfh5d4io	66	1	They	-PRON-	PRP
cord-296585-yfh5d4io	66	2	may	may	MD
cord-296585-yfh5d4io	66	3	reflect	reflect	VB
cord-296585-yfh5d4io	66	4	the	the	DT
cord-296585-yfh5d4io	66	5	dynamic	dynamic	JJ
cord-296585-yfh5d4io	66	6	response	response	NN
cord-296585-yfh5d4io	66	7	and	and	CC
cord-296585-yfh5d4io	66	8	attempts	attempt	NNS
cord-296585-yfh5d4io	66	9	by	by	IN
cord-296585-yfh5d4io	66	10	the	the	DT
cord-296585-yfh5d4io	66	11	airway	airway	NN
cord-296585-yfh5d4io	66	12	epithelial	epithelial	JJ
cord-296585-yfh5d4io	66	13	cells	cell	NNS
cord-296585-yfh5d4io	66	14	to	to	TO
cord-296585-yfh5d4io	66	15	repair	repair	VB
cord-296585-yfh5d4io	66	16	the	the	DT
cord-296585-yfh5d4io	66	17	cytotoxic	cytotoxic	JJ
cord-296585-yfh5d4io	66	18	injury	injury	NN
cord-296585-yfh5d4io	66	19	primarily	primarily	RB
cord-296585-yfh5d4io	66	20	triggered	trigger	VBN
cord-296585-yfh5d4io	66	21	by	by	IN
cord-296585-yfh5d4io	66	22	inhaled	inhale	VBN
cord-296585-yfh5d4io	66	23	irritants	irritant	NNS
cord-296585-yfh5d4io	66	24	.	.	.
cord-296585-yfh5d4io	67	1	Deleterious	deleterious	JJ
cord-296585-yfh5d4io	67	2	and	and	CC
cord-296585-yfh5d4io	67	3	irreversible	irreversible	JJ
cord-296585-yfh5d4io	67	4	alterations	alteration	NNS
cord-296585-yfh5d4io	67	5	occurring	occur	VBG
cord-296585-yfh5d4io	67	6	and	and	CC
cord-296585-yfh5d4io	67	7	interfering	interfere	VBG
cord-296585-yfh5d4io	67	8	with	with	IN
cord-296585-yfh5d4io	67	9	the	the	DT
cord-296585-yfh5d4io	67	10	airway	airway	NN
cord-296585-yfh5d4io	67	11	epithelial	epithelial	JJ
cord-296585-yfh5d4io	67	12	homeostasis	homeostasis	NN
cord-296585-yfh5d4io	67	13	and	and	CC
cord-296585-yfh5d4io	67	14	immune	immune	JJ
cord-296585-yfh5d4io	67	15	defense	defense	NN
cord-296585-yfh5d4io	67	16	may	may	MD
cord-296585-yfh5d4io	67	17	promote	promote	VB
cord-296585-yfh5d4io	67	18	COPD	COPD	NNP
cord-296585-yfh5d4io	67	19	development	development	NN
cord-296585-yfh5d4io	67	20	and	and	CC
cord-296585-yfh5d4io	67	21	progression	progression	NN
cord-296585-yfh5d4io	67	22	.	.	.
cord-296585-yfh5d4io	68	1	Notably	notably	RB
cord-296585-yfh5d4io	68	2	,	,	,
cord-296585-yfh5d4io	68	3	gene	gene	NN
cord-296585-yfh5d4io	68	4	alterations	alteration	NNS
cord-296585-yfh5d4io	68	5	in	in	IN
cord-296585-yfh5d4io	68	6	phagosomal	phagosomal	NN
cord-296585-yfh5d4io	68	7	-	-	:
cord-296585-yfh5d4io	68	8	and	and	CC
cord-296585-yfh5d4io	68	9	leukocyte	leukocyte	NN
cord-296585-yfh5d4io	68	10	transendothelial	transendothelial	NN
cord-296585-yfh5d4io	68	11	migration	migration	NN
cord-296585-yfh5d4io	68	12	pathways	pathway	NNS
cord-296585-yfh5d4io	68	13	(	(	-LRB-
cord-296585-yfh5d4io	68	14	LTM	LTM	NNP
cord-296585-yfh5d4io	68	15	)	)	-RRB-
cord-296585-yfh5d4io	68	16	are	be	VBP
cord-296585-yfh5d4io	68	17	significantly	significantly	RB
cord-296585-yfh5d4io	68	18	correlated	correlate	VBN
cord-296585-yfh5d4io	68	19	with	with	IN
cord-296585-yfh5d4io	68	20	the	the	DT
cord-296585-yfh5d4io	68	21	level	level	NN
cord-296585-yfh5d4io	68	22	of	of	IN
cord-296585-yfh5d4io	68	23	T	t	NN
cord-296585-yfh5d4io	68	24	cells	cell	NNS
cord-296585-yfh5d4io	68	25	and	and	CC
cord-296585-yfh5d4io	68	26	airway	airway	JJ
cord-296585-yfh5d4io	68	27	obstruction	obstruction	NN
cord-296585-yfh5d4io	68	28	in	in	IN
cord-296585-yfh5d4io	68	29	smokers	smoker	NNS
cord-296585-yfh5d4io	68	30	(	(	-LRB-
cord-296585-yfh5d4io	68	31	49	49	CD
cord-296585-yfh5d4io	68	32	)	)	-RRB-
cord-296585-yfh5d4io	68	33	.	.	.
cord-296585-yfh5d4io	69	1	The	the	DT
cord-296585-yfh5d4io	69	2	LTM	LTM	NNP
cord-296585-yfh5d4io	69	3	,	,	,
cord-296585-yfh5d4io	69	4	however	however	RB
cord-296585-yfh5d4io	69	5	,	,	,
cord-296585-yfh5d4io	69	6	were	be	VBD
cord-296585-yfh5d4io	69	7	found	find	VBN
cord-296585-yfh5d4io	69	8	to	to	TO
cord-296585-yfh5d4io	69	9	be	be	VB
cord-296585-yfh5d4io	69	10	further	further	RB
cord-296585-yfh5d4io	69	11	dysregulated	dysregulate	VBN
cord-296585-yfh5d4io	69	12	in	in	IN
cord-296585-yfh5d4io	69	13	COPD	COPD	NNP
cord-296585-yfh5d4io	69	14	patients	patient	NNS
cord-296585-yfh5d4io	69	15	.	.	.
cord-296585-yfh5d4io	70	1	Hence	hence	RB
cord-296585-yfh5d4io	70	2	,	,	,
cord-296585-yfh5d4io	70	3	in	in	IN
cord-296585-yfh5d4io	70	4	addition	addition	NN
cord-296585-yfh5d4io	70	5	to	to	IN
cord-296585-yfh5d4io	70	6	clinical	clinical	JJ
cord-296585-yfh5d4io	70	7	/	/	SYM
cord-296585-yfh5d4io	70	8	physiology	physiology	NN
cord-296585-yfh5d4io	70	9	variables	variable	NNS
cord-296585-yfh5d4io	70	10	,	,	,
cord-296585-yfh5d4io	70	11	a	a	DT
cord-296585-yfh5d4io	70	12	number	number	NN
cord-296585-yfh5d4io	70	13	of	of	IN
cord-296585-yfh5d4io	70	14	gene	gene	NN
cord-296585-yfh5d4io	70	15	products	product	NNS
cord-296585-yfh5d4io	70	16	with	with	IN
cord-296585-yfh5d4io	70	17	significant	significant	JJ
cord-296585-yfh5d4io	70	18	differential	differential	JJ
cord-296585-yfh5d4io	70	19	gene	gene	NN
cord-296585-yfh5d4io	70	20	expression	expression	NN
cord-296585-yfh5d4io	70	21	may	may	MD
cord-296585-yfh5d4io	70	22	be	be	VB
cord-296585-yfh5d4io	70	23	targeted	target	VBN
cord-296585-yfh5d4io	70	24	as	as	IN
cord-296585-yfh5d4io	70	25	specific	specific	JJ
cord-296585-yfh5d4io	70	26	proteomic	proteomic	JJ
cord-296585-yfh5d4io	70	27	signatures	signature	NNS
cord-296585-yfh5d4io	70	28	or	or	CC
cord-296585-yfh5d4io	70	29	biomarkers	biomarker	NNS
cord-296585-yfh5d4io	70	30	for	for	IN
cord-296585-yfh5d4io	70	31	early	early	JJ
cord-296585-yfh5d4io	70	32	COPD	COPD	NNP
cord-296585-yfh5d4io	70	33	detection	detection	NN
cord-296585-yfh5d4io	70	34	,	,	,
cord-296585-yfh5d4io	70	35	patient	patient	JJ
cord-296585-yfh5d4io	70	36	monitoring	monitoring	NN
cord-296585-yfh5d4io	70	37	,	,	,
cord-296585-yfh5d4io	70	38	disease	disease	NN
cord-296585-yfh5d4io	70	39	subgrouping	subgrouping	NN
cord-296585-yfh5d4io	70	40	,	,	,
cord-296585-yfh5d4io	70	41	and	and	CC
cord-296585-yfh5d4io	70	42	finally	finally	RB
cord-296585-yfh5d4io	70	43	treatment	treatment	NN
cord-296585-yfh5d4io	70	44	selection	selection	NN
cord-296585-yfh5d4io	70	45	(	(	-LRB-
cord-296585-yfh5d4io	70	46	50	50	CD
cord-296585-yfh5d4io	70	47	,	,	,
cord-296585-yfh5d4io	70	48	51	51	CD
cord-296585-yfh5d4io	70	49	)	)	-RRB-
cord-296585-yfh5d4io	70	50	.	.	.
cord-296585-yfh5d4io	71	1	Tobacco	tobacco	NN
cord-296585-yfh5d4io	71	2	or	or	CC
cord-296585-yfh5d4io	71	3	cigarette	cigarette	NN
cord-296585-yfh5d4io	71	4	smoke	smoke	NN
cord-296585-yfh5d4io	71	5	regulates	regulate	VBZ
cord-296585-yfh5d4io	71	6	airway	airway	NN
cord-296585-yfh5d4io	71	7	gene	gene	NN
cord-296585-yfh5d4io	71	8	expression	expression	NN
cord-296585-yfh5d4io	71	9	via	via	IN
cord-296585-yfh5d4io	71	10	two	two	CD
cord-296585-yfh5d4io	71	11	main	main	JJ
cord-296585-yfh5d4io	71	12	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	71	13	,	,	,
cord-296585-yfh5d4io	71	14	by	by	IN
cord-296585-yfh5d4io	71	15	altering	alter	VBG
cord-296585-yfh5d4io	71	16	the	the	DT
cord-296585-yfh5d4io	71	17	status	status	NN
cord-296585-yfh5d4io	71	18	of	of	IN
cord-296585-yfh5d4io	71	19	(	(	-LRB-
cord-296585-yfh5d4io	71	20	i	i	NN
cord-296585-yfh5d4io	71	21	)	)	-RRB-
cord-296585-yfh5d4io	71	22	chromatin	chromatin	NN
cord-296585-yfh5d4io	71	23	remodeling	remodeling	NN
cord-296585-yfh5d4io	71	24	,	,	,
cord-296585-yfh5d4io	71	25	and	and	CC
cord-296585-yfh5d4io	71	26	(	(	-LRB-
cord-296585-yfh5d4io	71	27	ii	ii	NN
cord-296585-yfh5d4io	71	28	)	)	-RRB-
cord-296585-yfh5d4io	71	29	DNA	dna	NN
cord-296585-yfh5d4io	71	30	methylation	methylation	NN
cord-296585-yfh5d4io	71	31	of	of	IN
cord-296585-yfh5d4io	71	32	the	the	DT
cord-296585-yfh5d4io	71	33	target	target	NN
cord-296585-yfh5d4io	71	34	genes	gene	NNS
cord-296585-yfh5d4io	71	35	(	(	-LRB-
cord-296585-yfh5d4io	71	36	Figure	figure	NN
cord-296585-yfh5d4io	71	37	1	1	CD
cord-296585-yfh5d4io	71	38	)	)	-RRB-
cord-296585-yfh5d4io	71	39	(	(	-LRB-
cord-296585-yfh5d4io	71	40	52	52	CD
cord-296585-yfh5d4io	71	41	-	-	SYM
cord-296585-yfh5d4io	71	42	54	54	CD
cord-296585-yfh5d4io	71	43	)	)	-RRB-
cord-296585-yfh5d4io	71	44	.	.	.
cord-296585-yfh5d4io	72	1	Chromatin	Chromatin	NNP
cord-296585-yfh5d4io	72	2	remodeling	remodeling	NN
cord-296585-yfh5d4io	72	3	is	be	VBZ
cord-296585-yfh5d4io	72	4	a	a	DT
cord-296585-yfh5d4io	72	5	result	result	NN
cord-296585-yfh5d4io	72	6	of	of	IN
cord-296585-yfh5d4io	72	7	a	a	DT
cord-296585-yfh5d4io	72	8	disrupted	disrupt	VBN
cord-296585-yfh5d4io	72	9	balance	balance	NN
cord-296585-yfh5d4io	72	10	in	in	IN
cord-296585-yfh5d4io	72	11	histone	histone	NNP
cord-296585-yfh5d4io	72	12	acetylation	acetylation	NN
cord-296585-yfh5d4io	72	13	/	/	SYM
cord-296585-yfh5d4io	72	14	deacetylation	deacetylation	NN
cord-296585-yfh5d4io	72	15	(	(	-LRB-
cord-296585-yfh5d4io	72	16	55	55	CD
cord-296585-yfh5d4io	72	17	)	)	-RRB-
cord-296585-yfh5d4io	72	18	.	.	.
cord-296585-yfh5d4io	73	1	Excessive	excessive	JJ
cord-296585-yfh5d4io	73	2	activation	activation	NN
cord-296585-yfh5d4io	73	3	of	of	IN
cord-296585-yfh5d4io	73	4	more	more	JJR
cord-296585-yfh5d4io	73	5	than	than	IN
cord-296585-yfh5d4io	73	6	20	20	CD
cord-296585-yfh5d4io	73	7	transcription	transcription	NN
cord-296585-yfh5d4io	73	8	factors	factor	NNS
cord-296585-yfh5d4io	73	9	including	include	VBG
cord-296585-yfh5d4io	73	10	NF	nf	NN
cord-296585-yfh5d4io	73	11	-	-	HYPH
cord-296585-yfh5d4io	73	12	κB	κB	NNP
cord-296585-yfh5d4io	73	13	,	,	,
cord-296585-yfh5d4io	73	14	and	and	CC
cord-296585-yfh5d4io	73	15	lipoprotein	lipoprotein	NN
cord-296585-yfh5d4io	73	16	peroxidation	peroxidation	NN
cord-296585-yfh5d4io	73	17	products	product	NNS
cord-296585-yfh5d4io	73	18	(	(	-LRB-
cord-296585-yfh5d4io	73	19	peroxinitrite	peroxinitrite	NNP
cord-296585-yfh5d4io	73	20	,	,	,
cord-296585-yfh5d4io	73	21	acrolein	acrolein	NN
cord-296585-yfh5d4io	73	22	,	,	,
cord-296585-yfh5d4io	73	23	and	and	CC
cord-296585-yfh5d4io	73	24	4HNE	4HNE	VBD
cord-296585-yfh5d4io	73	25	from	from	IN
cord-296585-yfh5d4io	73	26	tobacco	tobacco	NN
cord-296585-yfh5d4io	73	27	smoking	smoking	NN
cord-296585-yfh5d4io	73	28	)	)	-RRB-
cord-296585-yfh5d4io	73	29	contributes	contribute	VBZ
cord-296585-yfh5d4io	73	30	to	to	IN
cord-296585-yfh5d4io	73	31	such	such	JJ
cord-296585-yfh5d4io	73	32	anomaly	anomaly	NN
cord-296585-yfh5d4io	73	33	.	.	.
cord-296585-yfh5d4io	74	1	NF	NF	NNP
cord-296585-yfh5d4io	74	2	-	-	HYPH
cord-296585-yfh5d4io	74	3	κB	κB	NNP
cord-296585-yfh5d4io	74	4	is	be	VBZ
cord-296585-yfh5d4io	74	5	a	a	DT
cord-296585-yfh5d4io	74	6	key	key	JJ
cord-296585-yfh5d4io	74	7	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	74	8	and	and	CC
cord-296585-yfh5d4io	74	9	redox	redox	NN
cord-296585-yfh5d4io	74	10	-	-	HYPH
cord-296585-yfh5d4io	74	11	sensitive	sensitive	JJ
cord-296585-yfh5d4io	74	12	transcription	transcription	NN
cord-296585-yfh5d4io	74	13	factor	factor	NN
cord-296585-yfh5d4io	74	14	that	that	WDT
cord-296585-yfh5d4io	74	15	plays	play	VBZ
cord-296585-yfh5d4io	74	16	a	a	DT
cord-296585-yfh5d4io	74	17	direct	direct	JJ
cord-296585-yfh5d4io	74	18	role	role	NN
cord-296585-yfh5d4io	74	19	in	in	IN
cord-296585-yfh5d4io	74	20	cigarette	cigarette	NN
cord-296585-yfh5d4io	74	21	smoke	smoke	NN
cord-296585-yfh5d4io	74	22	-	-	HYPH
cord-296585-yfh5d4io	74	23	induced	induce	VBN
cord-296585-yfh5d4io	74	24	airway	airway	NN
cord-296585-yfh5d4io	74	25	inflammation	inflammation	NN
cord-296585-yfh5d4io	74	26	.	.	.
cord-296585-yfh5d4io	75	1	NF	NF	NNP
cord-296585-yfh5d4io	75	2	-	-	HYPH
cord-296585-yfh5d4io	75	3	κB	κB	NNP
cord-296585-yfh5d4io	75	4	has	have	VBZ
cord-296585-yfh5d4io	75	5	been	be	VBN
cord-296585-yfh5d4io	75	6	described	describe	VBN
cord-296585-yfh5d4io	75	7	as	as	IN
cord-296585-yfh5d4io	75	8	a	a	DT
cord-296585-yfh5d4io	75	9	"	"	``
cord-296585-yfh5d4io	75	10	smokesensor	smokesensor	NN
cord-296585-yfh5d4io	75	11	"	"	''
cord-296585-yfh5d4io	75	12	due	due	IN
cord-296585-yfh5d4io	75	13	to	to	IN
cord-296585-yfh5d4io	75	14	its	-PRON-	PRP$
cord-296585-yfh5d4io	75	15	sensitive	sensitive	JJ
cord-296585-yfh5d4io	75	16	activation	activation	NN
cord-296585-yfh5d4io	75	17	by	by	IN
cord-296585-yfh5d4io	75	18	tobacco	tobacco	NN
cord-296585-yfh5d4io	75	19	residues	residue	NNS
cord-296585-yfh5d4io	75	20	(	(	-LRB-
cord-296585-yfh5d4io	75	21	56	56	CD
cord-296585-yfh5d4io	75	22	)	)	-RRB-
cord-296585-yfh5d4io	75	23	.	.	.
cord-296585-yfh5d4io	76	1	Stimulation	stimulation	NN
cord-296585-yfh5d4io	76	2	of	of	IN
cord-296585-yfh5d4io	76	3	multiple	multiple	JJ
cord-296585-yfh5d4io	76	4	signaling	signaling	NN
cord-296585-yfh5d4io	76	5	cascades	cascade	NNS
cord-296585-yfh5d4io	76	6	[	[	-LRB-
cord-296585-yfh5d4io	76	7	p38	p38	CD
cord-296585-yfh5d4io	76	8	mitogenactivated	mitogenactivate	VBD
cord-296585-yfh5d4io	76	9	protein	protein	NNP
cord-296585-yfh5d4io	76	10	(	(	-LRB-
cord-296585-yfh5d4io	76	11	MAPK	MAPK	NNP
cord-296585-yfh5d4io	76	12	)	)	-RRB-
cord-296585-yfh5d4io	76	13	kinases	kinase	NNS
cord-296585-yfh5d4io	76	14	,	,	,
cord-296585-yfh5d4io	76	15	mitogen	mitogen	NN
cord-296585-yfh5d4io	76	16	and	and	CC
cord-296585-yfh5d4io	76	17	stress	stress	NN
cord-296585-yfh5d4io	76	18	-	-	HYPH
cord-296585-yfh5d4io	76	19	activated	activate	VBN
cord-296585-yfh5d4io	76	20	kinase	kinase	NN
cord-296585-yfh5d4io	76	21	1	1	CD
cord-296585-yfh5d4io	76	22	(	(	-LRB-
cord-296585-yfh5d4io	76	23	MSK1	MSK1	NNP
cord-296585-yfh5d4io	76	24	)	)	-RRB-
cord-296585-yfh5d4io	76	25	,	,	,
cord-296585-yfh5d4io	76	26	protein	protein	NN
cord-296585-yfh5d4io	76	27	kinase	kinase	NN
cord-296585-yfh5d4io	76	28	C	C	NNP
cord-296585-yfh5d4io	76	29	zeta	zeta	NNP
cord-296585-yfh5d4io	76	30	(	(	-LRB-
cord-296585-yfh5d4io	76	31	PKCζ	PKCζ	NNP
cord-296585-yfh5d4io	76	32	)	)	-RRB-
cord-296585-yfh5d4io	76	33	,	,	,
cord-296585-yfh5d4io	76	34	and	and	CC
cord-296585-yfh5d4io	76	35	IκB	iκb	NN
cord-296585-yfh5d4io	76	36	kinase	kinase	NN
cord-296585-yfh5d4io	76	37	(	(	-LRB-
cord-296585-yfh5d4io	76	38	IKK	IKK	NNP
cord-296585-yfh5d4io	76	39	)	)	-RRB-
cord-296585-yfh5d4io	76	40	complex	complex	NNP
cord-296585-yfh5d4io	76	41	(	(	-LRB-
cord-296585-yfh5d4io	76	42	IKKα	IKKα	NNP
cord-296585-yfh5d4io	76	43	,	,	,
cord-296585-yfh5d4io	76	44	IKKβ	IKKβ	NNS
cord-296585-yfh5d4io	76	45	,	,	,
cord-296585-yfh5d4io	76	46	and	and	CC
cord-296585-yfh5d4io	76	47	NEMO	NEMO	NNP
cord-296585-yfh5d4io	76	48	)	)	-RRB-
cord-296585-yfh5d4io	76	49	]	]	-RRB-
cord-296585-yfh5d4io	77	1	by	by	IN
cord-296585-yfh5d4io	77	2	tobacco	tobacco	NN
cord-296585-yfh5d4io	77	3	residues	residue	NNS
cord-296585-yfh5d4io	77	4	promotes	promote	VBZ
cord-296585-yfh5d4io	77	5	the	the	DT
cord-296585-yfh5d4io	77	6	activation	activation	NN
cord-296585-yfh5d4io	77	7	and	and	CC
cord-296585-yfh5d4io	77	8	nuclear	nuclear	JJ
cord-296585-yfh5d4io	77	9	translocation	translocation	NN
cord-296585-yfh5d4io	77	10	of	of	IN
cord-296585-yfh5d4io	77	11	transcription	transcription	NN
cord-296585-yfh5d4io	77	12	factor	factor	NN
cord-296585-yfh5d4io	77	13	NF	nf	NN
cord-296585-yfh5d4io	78	1	-κB	-κB	:
cord-296585-yfh5d4io	78	2	RelA	RelA	NNP
cord-296585-yfh5d4io	78	3	/	/	SYM
cord-296585-yfh5d4io	78	4	p65	p65	NN
cord-296585-yfh5d4io	78	5	(	(	-LRB-
cord-296585-yfh5d4io	78	6	54	54	CD
cord-296585-yfh5d4io	78	7	,	,	,
cord-296585-yfh5d4io	78	8	57	57	CD
cord-296585-yfh5d4io	78	9	-	-	SYM
cord-296585-yfh5d4io	78	10	64	64	CD
cord-296585-yfh5d4io	78	11	)	)	-RRB-
cord-296585-yfh5d4io	78	12	.	.	.
cord-296585-yfh5d4io	79	1	This	this	DT
cord-296585-yfh5d4io	79	2	is	be	VBZ
cord-296585-yfh5d4io	79	3	followed	follow	VBN
cord-296585-yfh5d4io	79	4	by	by	IN
cord-296585-yfh5d4io	79	5	a	a	DT
cord-296585-yfh5d4io	79	6	complex	complex	JJ
cord-296585-yfh5d4io	79	7	formation	formation	NN
cord-296585-yfh5d4io	79	8	of	of	IN
cord-296585-yfh5d4io	79	9	NF	nf	NN
cord-296585-yfh5d4io	80	1	-κB	-κB	NFP
cord-296585-yfh5d4io	80	2	/	/	SYM
cord-296585-yfh5d4io	80	3	CBP	CBP	NNP
cord-296585-yfh5d4io	80	4	-	-	HYPH
cord-296585-yfh5d4io	80	5	p300	p300	NNP
cord-296585-yfh5d4io	80	6	[	[	-LRB-
cord-296585-yfh5d4io	80	7	coactivator	coactivator	NN
cord-296585-yfh5d4io	80	8	,	,	,
cord-296585-yfh5d4io	80	9	CREBbinding	crebbinding	NN
cord-296585-yfh5d4io	80	10	protein	protein	NN
cord-296585-yfh5d4io	80	11	(	(	-LRB-
cord-296585-yfh5d4io	80	12	CBP	CBP	NNP
cord-296585-yfh5d4io	80	13	)	)	-RRB-
cord-296585-yfh5d4io	80	14	or	or	CC
cord-296585-yfh5d4io	80	15	CBP	CBP	NNP
cord-296585-yfh5d4io	80	16	/	/	SYM
cord-296585-yfh5d4io	80	17	p300	p300	NNP
cord-296585-yfh5d4io	80	18	]	]	-RRB-
cord-296585-yfh5d4io	80	19	at	at	IN
cord-296585-yfh5d4io	80	20	target	target	NN
cord-296585-yfh5d4io	80	21	DNA	dna	NN
cord-296585-yfh5d4io	80	22	sequences	sequence	NNS
cord-296585-yfh5d4io	80	23	.	.	.
cord-296585-yfh5d4io	81	1	It	-PRON-	PRP
cord-296585-yfh5d4io	81	2	should	should	MD
cord-296585-yfh5d4io	81	3	be	be	VB
cord-296585-yfh5d4io	81	4	noted	note	VBN
cord-296585-yfh5d4io	81	5	that	that	IN
cord-296585-yfh5d4io	81	6	CBP	CBP	NNP
cord-296585-yfh5d4io	81	7	/	/	SYM
cord-296585-yfh5d4io	81	8	p300	p300	NNP
cord-296585-yfh5d4io	81	9	also	also	RB
cord-296585-yfh5d4io	81	10	has	have	VBZ
cord-296585-yfh5d4io	81	11	intrinsic	intrinsic	JJ
cord-296585-yfh5d4io	81	12	histone	histone	NN
cord-296585-yfh5d4io	81	13	acetyltransferase	acetyltransferase	NN
cord-296585-yfh5d4io	81	14	(	(	-LRB-
cord-296585-yfh5d4io	81	15	HAT	hat	NN
cord-296585-yfh5d4io	81	16	)	)	-RRB-
cord-296585-yfh5d4io	81	17	activity	activity	NN
cord-296585-yfh5d4io	81	18	.	.	.
cord-296585-yfh5d4io	82	1	Subsequent	subsequent	JJ
cord-296585-yfh5d4io	82	2	acetylation	acetylation	NN
cord-296585-yfh5d4io	82	3	and	and	CC
cord-296585-yfh5d4io	82	4	phosphorylation	phosphorylation	NN
cord-296585-yfh5d4io	82	5	of	of	IN
cord-296585-yfh5d4io	82	6	the	the	DT
cord-296585-yfh5d4io	82	7	subunit	subunit	NN
cord-296585-yfh5d4io	82	8	p65	p65	NN
cord-296585-yfh5d4io	82	9	in	in	IN
cord-296585-yfh5d4io	82	10	the	the	DT
cord-296585-yfh5d4io	82	11	NF	nf	NN
cord-296585-yfh5d4io	82	12	-	-	HYPH
cord-296585-yfh5d4io	82	13	κB	κB	NNP
cord-296585-yfh5d4io	82	14	/	/	SYM
cord-296585-yfh5d4io	82	15	CBP	CBP	NNP
cord-296585-yfh5d4io	82	16	-	-	HYPH
cord-296585-yfh5d4io	82	17	p300	p300	NNP
cord-296585-yfh5d4io	82	18	complex	complex	NN
cord-296585-yfh5d4io	82	19	by	by	IN
cord-296585-yfh5d4io	82	20	the	the	DT
cord-296585-yfh5d4io	82	21	activated	activate	VBN
cord-296585-yfh5d4io	82	22	MSK1	MSK1	NNP
cord-296585-yfh5d4io	82	23	/	/	SYM
cord-296585-yfh5d4io	82	24	PKCζ	pkcζ	NN
cord-296585-yfh5d4io	82	25	-	-	HYPH
cord-296585-yfh5d4io	82	26	signaling	signal	VBG
cord-296585-yfh5d4io	82	27	pathways	pathway	NNS
cord-296585-yfh5d4io	82	28	(	(	-LRB-
cord-296585-yfh5d4io	82	29	and	and	CC
cord-296585-yfh5d4io	82	30	other	other	JJ
cord-296585-yfh5d4io	82	31	11	11	CD
cord-296585-yfh5d4io	82	32	different	different	JJ
cord-296585-yfh5d4io	82	33	kinases	kinase	NNS
cord-296585-yfh5d4io	82	34	)	)	-RRB-
cord-296585-yfh5d4io	82	35	,	,	,
cord-296585-yfh5d4io	82	36	and	and	CC
cord-296585-yfh5d4io	82	37	CBP	CBP	NNP
cord-296585-yfh5d4io	82	38	/	/	SYM
cord-296585-yfh5d4io	82	39	p300	p300	NN
cord-296585-yfh5d4io	82	40	,	,	,
cord-296585-yfh5d4io	82	41	respectively	respectively	RB
cord-296585-yfh5d4io	82	42	,	,	,
cord-296585-yfh5d4io	82	43	are	be	VBP
cord-296585-yfh5d4io	82	44	required	require	VBN
cord-296585-yfh5d4io	82	45	for	for	IN
cord-296585-yfh5d4io	82	46	the	the	DT
cord-296585-yfh5d4io	82	47	full	full	JJ
cord-296585-yfh5d4io	82	48	activation	activation	NN
cord-296585-yfh5d4io	82	49	of	of	IN
cord-296585-yfh5d4io	82	50	NF	nf	NN
cord-296585-yfh5d4io	82	51	-	-	HYPH
cord-296585-yfh5d4io	82	52	κB	κB	NNP
cord-296585-yfh5d4io	82	53	(	(	-LRB-
cord-296585-yfh5d4io	82	54	57	57	CD
cord-296585-yfh5d4io	82	55	,	,	,
cord-296585-yfh5d4io	82	56	60	60	CD
cord-296585-yfh5d4io	82	57	,	,	,
cord-296585-yfh5d4io	82	58	63	63	CD
cord-296585-yfh5d4io	82	59	)	)	-RRB-
cord-296585-yfh5d4io	82	60	.	.	.
cord-296585-yfh5d4io	83	1	This	this	DT
cord-296585-yfh5d4io	83	2	enhances	enhance	VBZ
cord-296585-yfh5d4io	83	3	the	the	DT
cord-296585-yfh5d4io	83	4	DNA	dna	NN
cord-296585-yfh5d4io	83	5	binding	binding	NN
cord-296585-yfh5d4io	83	6	affinity	affinity	NN
cord-296585-yfh5d4io	83	7	of	of	IN
cord-296585-yfh5d4io	83	8	the	the	DT
cord-296585-yfh5d4io	83	9	complex	complex	NN
cord-296585-yfh5d4io	83	10	.	.	.
cord-296585-yfh5d4io	84	1	Histones	Histones	NNP
cord-296585-yfh5d4io	84	2	H3	H3	NNP
cord-296585-yfh5d4io	84	3	and	and	CC
cord-296585-yfh5d4io	84	4	H4	H4	NNP
cord-296585-yfh5d4io	84	5	in	in	IN
cord-296585-yfh5d4io	84	6	the	the	DT
cord-296585-yfh5d4io	84	7	chromatin	chromatin	NN
cord-296585-yfh5d4io	84	8	complex	complex	NN
cord-296585-yfh5d4io	84	9	of	of	IN
cord-296585-yfh5d4io	84	10	target	target	NN
cord-296585-yfh5d4io	84	11	sequences	sequence	NNS
cord-296585-yfh5d4io	84	12	are	be	VBP
cord-296585-yfh5d4io	84	13	then	then	RB
cord-296585-yfh5d4io	84	14	being	be	VBG
cord-296585-yfh5d4io	84	15	acetylated	acetylate	VBN
cord-296585-yfh5d4io	84	16	(	(	-LRB-
cord-296585-yfh5d4io	84	17	histone	histone	NN
cord-296585-yfh5d4io	84	18	H3	H3	NNP
cord-296585-yfh5d4io	84	19	at	at	IN
cord-296585-yfh5d4io	84	20	Lys9	lys9	NN
cord-296585-yfh5d4io	84	21	;	;	:
cord-296585-yfh5d4io	84	22	H4	h4	NN
cord-296585-yfh5d4io	84	23	at	at	IN
cord-296585-yfh5d4io	84	24	Lys8	Lys8	NNP
cord-296585-yfh5d4io	84	25	and	and	CC
cord-296585-yfh5d4io	84	26	Lys12	Lys12	NNP
cord-296585-yfh5d4io	84	27	)	)	-RRB-
cord-296585-yfh5d4io	84	28	and	and	CC
cord-296585-yfh5d4io	84	29	phosphorylated	phosphorylate	VBN
cord-296585-yfh5d4io	84	30	(	(	-LRB-
cord-296585-yfh5d4io	84	31	histone	histone	JJ
cord-296585-yfh5d4io	84	32	H3	H3	NNP
cord-296585-yfh5d4io	84	33	at	at	IN
cord-296585-yfh5d4io	84	34	Ser10	Ser10	NNP
cord-296585-yfh5d4io	84	35	)	)	-RRB-
cord-296585-yfh5d4io	84	36	by	by	IN
cord-296585-yfh5d4io	84	37	the	the	DT
cord-296585-yfh5d4io	84	38	subunit	subunit	NN
cord-296585-yfh5d4io	84	39	CBP	CBP	NNP
cord-296585-yfh5d4io	84	40	of	of	IN
cord-296585-yfh5d4io	84	41	the	the	DT
cord-296585-yfh5d4io	84	42	NF	nf	NN
cord-296585-yfh5d4io	84	43	-	-	HYPH
cord-296585-yfh5d4io	84	44	κB	κB	NNP
cord-296585-yfh5d4io	84	45	/	/	SYM
cord-296585-yfh5d4io	84	46	CBP	CBP	NNP
cord-296585-yfh5d4io	84	47	-	-	HYPH
cord-296585-yfh5d4io	84	48	p300	p300	NNP
cord-296585-yfh5d4io	84	49	complex	complex	NN
cord-296585-yfh5d4io	84	50	,	,	,
cord-296585-yfh5d4io	84	51	and	and	CC
cord-296585-yfh5d4io	84	52	the	the	DT
cord-296585-yfh5d4io	84	53	activated	activate	VBN
cord-296585-yfh5d4io	84	54	MSK1	MSK1	NNP
cord-296585-yfh5d4io	84	55	and	and	CC
cord-296585-yfh5d4io	84	56	PKCζ	PKCζ	NNS
cord-296585-yfh5d4io	84	57	,	,	,
cord-296585-yfh5d4io	84	58	respectively	respectively	RB
cord-296585-yfh5d4io	84	59	.	.	.
cord-296585-yfh5d4io	85	1	The	the	DT
cord-296585-yfh5d4io	85	2	hyperacetylated	hyperacetylated	JJ
cord-296585-yfh5d4io	85	3	core	core	NN
cord-296585-yfh5d4io	85	4	histones	histone	NNS
cord-296585-yfh5d4io	85	5	,	,	,
cord-296585-yfh5d4io	85	6	however	however	RB
cord-296585-yfh5d4io	85	7	,	,	,
cord-296585-yfh5d4io	85	8	fail	fail	VBP
cord-296585-yfh5d4io	85	9	to	to	TO
cord-296585-yfh5d4io	85	10	be	be	VB
cord-296585-yfh5d4io	85	11	neutralized	neutralize	VBN
cord-296585-yfh5d4io	85	12	or	or	CC
cord-296585-yfh5d4io	85	13	deacetylated	deacetylate	VBN
cord-296585-yfh5d4io	85	14	by	by	IN
cord-296585-yfh5d4io	85	15	a	a	DT
cord-296585-yfh5d4io	85	16	dysfunctional	dysfunctional	JJ
cord-296585-yfh5d4io	85	17	histone	histone	NN
cord-296585-yfh5d4io	85	18	deacetylase	deacetylase	NN
cord-296585-yfh5d4io	85	19	(	(	-LRB-
cord-296585-yfh5d4io	85	20	HDAC2	HDAC2	NNP
cord-296585-yfh5d4io	85	21	)	)	-RRB-
cord-296585-yfh5d4io	85	22	.	.	.
cord-296585-yfh5d4io	86	1	Peroxinitrite	Peroxinitrite	NNP
cord-296585-yfh5d4io	86	2	nitrates	nitrate	NNS
cord-296585-yfh5d4io	86	3	the	the	DT
cord-296585-yfh5d4io	86	4	tyrosine	tyrosine	NN
cord-296585-yfh5d4io	86	5	residues	residue	NNS
cord-296585-yfh5d4io	86	6	of	of	IN
cord-296585-yfh5d4io	86	7	the	the	DT
cord-296585-yfh5d4io	86	8	HDAC2	hdac2	NN
cord-296585-yfh5d4io	86	9	and	and	CC
cord-296585-yfh5d4io	86	10	causes	cause	VBZ
cord-296585-yfh5d4io	86	11	inhibition	inhibition	NN
cord-296585-yfh5d4io	86	12	of	of	IN
cord-296585-yfh5d4io	86	13	activation	activation	NN
cord-296585-yfh5d4io	86	14	and	and	CC
cord-296585-yfh5d4io	86	15	reduced	reduced	JJ
cord-296585-yfh5d4io	86	16	expression	expression	NN
cord-296585-yfh5d4io	86	17	of	of	IN
cord-296585-yfh5d4io	86	18	the	the	DT
cord-296585-yfh5d4io	86	19	protein	protein	NN
cord-296585-yfh5d4io	86	20	.	.	.
cord-296585-yfh5d4io	87	1	Of	of	IN
cord-296585-yfh5d4io	87	2	note	note	NN
cord-296585-yfh5d4io	87	3	,	,	,
cord-296585-yfh5d4io	87	4	peroxinitrite	peroxinitrite	NNP
cord-296585-yfh5d4io	87	5	is	be	VBZ
cord-296585-yfh5d4io	87	6	a	a	DT
cord-296585-yfh5d4io	87	7	by	by	IN
cord-296585-yfh5d4io	87	8	-	-	HYPH
cord-296585-yfh5d4io	87	9	product	product	NN
cord-296585-yfh5d4io	87	10	generated	generate	VBN
cord-296585-yfh5d4io	87	11	from	from	IN
cord-296585-yfh5d4io	87	12	the	the	DT
cord-296585-yfh5d4io	87	13	immune	immune	JJ
cord-296585-yfh5d4io	87	14	cell	cell	NN
cord-296585-yfh5d4io	87	15	-	-	HYPH
cord-296585-yfh5d4io	87	16	derived	derive	VBN
cord-296585-yfh5d4io	87	17	nitrite	nitrite	NN
cord-296585-yfh5d4io	87	18	oxide	oxide	NN
cord-296585-yfh5d4io	87	19	(	(	-LRB-
cord-296585-yfh5d4io	87	20	NO	no	UH
cord-296585-yfh5d4io	87	21	)	)	-RRB-
cord-296585-yfh5d4io	87	22	and	and	CC
cord-296585-yfh5d4io	87	23	reactive	reactive	JJ
cord-296585-yfh5d4io	87	24	oxygen	oxygen	NN
cord-296585-yfh5d4io	87	25	species	specie	NNS
cord-296585-yfh5d4io	87	26	(	(	-LRB-
cord-296585-yfh5d4io	87	27	ROS	ROS	NNP
cord-296585-yfh5d4io	87	28	)	)	-RRB-
cord-296585-yfh5d4io	87	29	of	of	IN
cord-296585-yfh5d4io	87	30	cigarette	cigarette	NN
cord-296585-yfh5d4io	87	31	smoke	smoke	NN
cord-296585-yfh5d4io	87	32	(	(	-LRB-
cord-296585-yfh5d4io	87	33	65	65	CD
cord-296585-yfh5d4io	87	34	,	,	,
cord-296585-yfh5d4io	87	35	66	66	CD
cord-296585-yfh5d4io	87	36	)	)	-RRB-
cord-296585-yfh5d4io	87	37	.	.	.
cord-296585-yfh5d4io	88	1	Cigarette	cigarette	NN
cord-296585-yfh5d4io	88	2	or	or	CC
cord-296585-yfh5d4io	88	3	tobacco	tobacco	NN
cord-296585-yfh5d4io	88	4	smoke	smoke	NN
cord-296585-yfh5d4io	88	5	disturbs	disturb	VBZ
cord-296585-yfh5d4io	88	6	the	the	DT
cord-296585-yfh5d4io	88	7	DNA	dna	NN
cord-296585-yfh5d4io	88	8	methylation	methylation	NN
cord-296585-yfh5d4io	88	9	status	status	NN
cord-296585-yfh5d4io	88	10	of	of	IN
cord-296585-yfh5d4io	88	11	target	target	NN
cord-296585-yfh5d4io	88	12	genes	gene	NNS
cord-296585-yfh5d4io	88	13	through	through	IN
cord-296585-yfh5d4io	88	14	several	several	JJ
cord-296585-yfh5d4io	88	15	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	88	16	.	.	.
cord-296585-yfh5d4io	89	1	Firstly	firstly	RB
cord-296585-yfh5d4io	89	2	,	,	,
cord-296585-yfh5d4io	89	3	DNA	dna	NN
cord-296585-yfh5d4io	89	4	damage	damage	NN
cord-296585-yfh5d4io	89	5	caused	cause	VBN
cord-296585-yfh5d4io	89	6	by	by	IN
cord-296585-yfh5d4io	89	7	cigarette	cigarette	NN
cord-296585-yfh5d4io	89	8	smoke	smoke	NN
cord-296585-yfh5d4io	89	9	stimulates	stimulate	VBZ
cord-296585-yfh5d4io	89	10	the	the	DT
cord-296585-yfh5d4io	89	11	DNA	dna	NN
cord-296585-yfh5d4io	89	12	methyltransferase	methyltransferase	NN
cord-296585-yfh5d4io	89	13	1	1	CD
cord-296585-yfh5d4io	89	14	(	(	-LRB-
cord-296585-yfh5d4io	89	15	DNMT	DNMT	NNP
cord-296585-yfh5d4io	89	16	)	)	-RRB-
cord-296585-yfh5d4io	89	17	to	to	TO
cord-296585-yfh5d4io	89	18	actively	actively	RB
cord-296585-yfh5d4io	89	19	induce	induce	VB
cord-296585-yfh5d4io	89	20	CpGs	CpGs	NNP
cord-296585-yfh5d4io	89	21	methylation	methylation	NN
cord-296585-yfh5d4io	89	22	at	at	IN
cord-296585-yfh5d4io	89	23	the	the	DT
cord-296585-yfh5d4io	89	24	damaged	damage	VBN
cord-296585-yfh5d4io	89	25	site	site	NN
cord-296585-yfh5d4io	89	26	(	(	-LRB-
cord-296585-yfh5d4io	89	27	67	67	CD
cord-296585-yfh5d4io	89	28	)	)	-RRB-
cord-296585-yfh5d4io	89	29	.	.	.
cord-296585-yfh5d4io	90	1	The	the	DT
cord-296585-yfh5d4io	90	2	hypermethylation	hypermethylation	NN
cord-296585-yfh5d4io	90	3	is	be	VBZ
cord-296585-yfh5d4io	90	4	prone	prone	JJ
cord-296585-yfh5d4io	90	5	to	to	TO
cord-296585-yfh5d4io	90	6	introduce	introduce	VB
cord-296585-yfh5d4io	90	7	error	error	NN
cord-296585-yfh5d4io	90	8	of	of	IN
cord-296585-yfh5d4io	90	9	methylation	methylation	NN
cord-296585-yfh5d4io	90	10	in	in	IN
cord-296585-yfh5d4io	90	11	some	some	DT
cord-296585-yfh5d4io	90	12	target	target	NN
cord-296585-yfh5d4io	90	13	genes	gene	NNS
cord-296585-yfh5d4io	90	14	,	,	,
cord-296585-yfh5d4io	90	15	resulting	result	VBG
cord-296585-yfh5d4io	90	16	in	in	IN
cord-296585-yfh5d4io	90	17	reduced	reduce	VBN
cord-296585-yfh5d4io	90	18	gene	gene	NN
cord-296585-yfh5d4io	90	19	expression	expression	NN
cord-296585-yfh5d4io	90	20	.	.	.
cord-296585-yfh5d4io	91	1	Secondly	secondly	RB
cord-296585-yfh5d4io	91	2	,	,	,
cord-296585-yfh5d4io	91	3	activation	activation	NN
cord-296585-yfh5d4io	91	4	of	of	IN
cord-296585-yfh5d4io	91	5	nicotine	nicotine	NN
cord-296585-yfh5d4io	91	6	signaling	signal	VBG
cord-296585-yfh5d4io	91	7	pathway	pathway	NN
cord-296585-yfh5d4io	91	8	by	by	IN
cord-296585-yfh5d4io	91	9	tobacco	tobacco	NN
cord-296585-yfh5d4io	91	10	smoke	smoke	NN
cord-296585-yfh5d4io	91	11	causes	cause	VBZ
cord-296585-yfh5d4io	91	12	CaMKII	CaMKII	NNP
cord-296585-yfh5d4io	91	13	/	/	SYM
cord-296585-yfh5d4io	91	14	IV	IV	NNP
cord-296585-yfh5d4io	91	15	and	and	CC
cord-296585-yfh5d4io	91	16	ERK	ERK	NNP
cord-296585-yfh5d4io	91	17	/	/	SYM
cord-296585-yfh5d4io	91	18	MAPK	MAPK	NNP
cord-296585-yfh5d4io	91	19	pathway	pathway	NN
cord-296585-yfh5d4io	91	20	activation	activation	NN
cord-296585-yfh5d4io	91	21	that	that	WDT
cord-296585-yfh5d4io	91	22	subsequently	subsequently	RB
cord-296585-yfh5d4io	91	23	induces	induce	VBZ
cord-296585-yfh5d4io	91	24	the	the	DT
cord-296585-yfh5d4io	91	25	activity	activity	NN
cord-296585-yfh5d4io	91	26	of	of	IN
cord-296585-yfh5d4io	91	27	CBP	CBP	NNP
cord-296585-yfh5d4io	91	28	to	to	TO
cord-296585-yfh5d4io	91	29	suppress	suppress	VB
cord-296585-yfh5d4io	91	30	the	the	DT
cord-296585-yfh5d4io	91	31	expression	expression	NN
cord-296585-yfh5d4io	91	32	of	of	IN
cord-296585-yfh5d4io	91	33	DNMT1	DNMT1	NNS
cord-296585-yfh5d4io	91	34	.	.	.
cord-296585-yfh5d4io	92	1	This	this	DT
cord-296585-yfh5d4io	92	2	may	may	MD
cord-296585-yfh5d4io	92	3	result	result	VB
cord-296585-yfh5d4io	92	4	in	in	IN
cord-296585-yfh5d4io	92	5	reduced	reduce	VBN
cord-296585-yfh5d4io	92	6	DNA	dna	NN
cord-296585-yfh5d4io	92	7	methylation	methylation	NN
cord-296585-yfh5d4io	92	8	and	and	CC
cord-296585-yfh5d4io	92	9	thus	thus	RB
cord-296585-yfh5d4io	92	10	altered	alter	VBN
cord-296585-yfh5d4io	92	11	level	level	NN
cord-296585-yfh5d4io	92	12	of	of	IN
cord-296585-yfh5d4io	92	13	gene	gene	NN
cord-296585-yfh5d4io	92	14	repression	repression	NN
cord-296585-yfh5d4io	92	15	by	by	IN
cord-296585-yfh5d4io	92	16	DNMT	DNMT	NNP
cord-296585-yfh5d4io	92	17	(	(	-LRB-
cord-296585-yfh5d4io	92	18	68	68	CD
cord-296585-yfh5d4io	92	19	-	-	SYM
cord-296585-yfh5d4io	92	20	70	70	CD
cord-296585-yfh5d4io	92	21	)	)	-RRB-
cord-296585-yfh5d4io	92	22	.	.	.
cord-296585-yfh5d4io	93	1	Finally	finally	RB
cord-296585-yfh5d4io	93	2	,	,	,
cord-296585-yfh5d4io	93	3	enhanced	enhanced	JJ
cord-296585-yfh5d4io	93	4	activities	activity	NNS
cord-296585-yfh5d4io	93	5	of	of	IN
cord-296585-yfh5d4io	93	6	transcription	transcription	NN
cord-296585-yfh5d4io	93	7	factors	factor	NNS
cord-296585-yfh5d4io	93	8	such	such	JJ
cord-296585-yfh5d4io	93	9	as	as	IN
cord-296585-yfh5d4io	93	10	hypoxia	hypoxia	NN
cord-296585-yfh5d4io	93	11	inducible	inducible	JJ
cord-296585-yfh5d4io	93	12	factor	factor	NN
cord-296585-yfh5d4io	93	13	1	1	CD
cord-296585-yfh5d4io	93	14	due	due	IN
cord-296585-yfh5d4io	93	15	to	to	IN
cord-296585-yfh5d4io	93	16	the	the	DT
cord-296585-yfh5d4io	93	17	high	high	JJ
cord-296585-yfh5d4io	93	18	level	level	NN
cord-296585-yfh5d4io	93	19	of	of	IN
cord-296585-yfh5d4io	93	20	carbon	carbon	NN
cord-296585-yfh5d4io	93	21	monoxide	monoxide	NN
cord-296585-yfh5d4io	93	22	and	and	CC
cord-296585-yfh5d4io	93	23	hypoxia	hypoxia	NN
cord-296585-yfh5d4io	93	24	have	have	VBP
cord-296585-yfh5d4io	93	25	also	also	RB
cord-296585-yfh5d4io	93	26	been	be	VBN
cord-296585-yfh5d4io	93	27	reported	report	VBN
cord-296585-yfh5d4io	93	28	to	to	TO
cord-296585-yfh5d4io	93	29	influence	influence	VB
cord-296585-yfh5d4io	93	30	airway	airway	NN
cord-296585-yfh5d4io	93	31	gene	gene	NN
cord-296585-yfh5d4io	93	32	expression	expression	NN
cord-296585-yfh5d4io	93	33	(	(	-LRB-
cord-296585-yfh5d4io	93	34	71	71	CD
cord-296585-yfh5d4io	93	35	)	)	-RRB-
cord-296585-yfh5d4io	93	36	.	.	.
cord-296585-yfh5d4io	94	1	Consequently	consequently	RB
cord-296585-yfh5d4io	94	2	,	,	,
cord-296585-yfh5d4io	94	3	the	the	DT
cord-296585-yfh5d4io	94	4	combinatorial	combinatorial	JJ
cord-296585-yfh5d4io	94	5	effect	effect	NN
cord-296585-yfh5d4io	94	6	from	from	IN
cord-296585-yfh5d4io	94	7	both	both	CC
cord-296585-yfh5d4io	94	8	aberrant	aberrant	JJ
cord-296585-yfh5d4io	94	9	acetylation	acetylation	NN
cord-296585-yfh5d4io	94	10	of	of	IN
cord-296585-yfh5d4io	94	11	histone	histone	NN
cord-296585-yfh5d4io	94	12	and	and	CC
cord-296585-yfh5d4io	94	13	DNA	dna	NN
cord-296585-yfh5d4io	94	14	methylation	methylation	NN
cord-296585-yfh5d4io	94	15	promotes	promote	VBZ
cord-296585-yfh5d4io	94	16	the	the	DT
cord-296585-yfh5d4io	94	17	transformation	transformation	NN
cord-296585-yfh5d4io	94	18	of	of	IN
cord-296585-yfh5d4io	94	19	chromatin	chromatin	NN
cord-296585-yfh5d4io	94	20	from	from	IN
cord-296585-yfh5d4io	94	21	a	a	DT
cord-296585-yfh5d4io	94	22	condensed	condense	VBN
cord-296585-yfh5d4io	94	23	structure	structure	NN
cord-296585-yfh5d4io	94	24	to	to	IN
cord-296585-yfh5d4io	94	25	an	an	DT
cord-296585-yfh5d4io	94	26	activated	activate	VBN
cord-296585-yfh5d4io	94	27	open	open	JJ
cord-296585-yfh5d4io	94	28	conformation	conformation	NN
cord-296585-yfh5d4io	94	29	.	.	.
cord-296585-yfh5d4io	95	1	This	this	DT
cord-296585-yfh5d4io	95	2	facilitates	facilitate	VBZ
cord-296585-yfh5d4io	95	3	irregular	irregular	JJ
cord-296585-yfh5d4io	95	4	accessibility	accessibility	NN
cord-296585-yfh5d4io	95	5	of	of	IN
cord-296585-yfh5d4io	95	6	DNA	dna	NN
cord-296585-yfh5d4io	95	7	for	for	IN
cord-296585-yfh5d4io	95	8	transcription	transcription	NN
cord-296585-yfh5d4io	95	9	machineries	machinery	NNS
cord-296585-yfh5d4io	95	10	,	,	,
cord-296585-yfh5d4io	95	11	hence	hence	RB
cord-296585-yfh5d4io	95	12	FIGURE	figure	NN
cord-296585-yfh5d4io	96	1	1	1	LS
cord-296585-yfh5d4io	96	2	|	|	NNP
cord-296585-yfh5d4io	96	3	Cigarette	cigarette	NN
cord-296585-yfh5d4io	96	4	and	and	CC
cord-296585-yfh5d4io	96	5	tobacco	tobacco	NN
cord-296585-yfh5d4io	96	6	smoke	smoke	NN
cord-296585-yfh5d4io	96	7	has	have	VBZ
cord-296585-yfh5d4io	96	8	several	several	JJ
cord-296585-yfh5d4io	96	9	effects	effect	NNS
cord-296585-yfh5d4io	96	10	on	on	IN
cord-296585-yfh5d4io	96	11	gene	gene	NN
cord-296585-yfh5d4io	96	12	regulation	regulation	NN
cord-296585-yfh5d4io	96	13	.	.	.
cord-296585-yfh5d4io	97	1	Nicotine	nicotine	NN
cord-296585-yfh5d4io	97	2	and	and	CC
cord-296585-yfh5d4io	97	3	other	other	JJ
cord-296585-yfh5d4io	97	4	compounds	compound	NNS
cord-296585-yfh5d4io	97	5	in	in	IN
cord-296585-yfh5d4io	97	6	the	the	DT
cord-296585-yfh5d4io	97	7	smoke	smoke	NN
cord-296585-yfh5d4io	97	8	alter	alter	VB
cord-296585-yfh5d4io	97	9	gene	gene	NN
cord-296585-yfh5d4io	97	10	expression	expression	NN
cord-296585-yfh5d4io	97	11	by	by	IN
cord-296585-yfh5d4io	97	12	two	two	CD
cord-296585-yfh5d4io	97	13	pathways	pathway	NNS
cord-296585-yfh5d4io	97	14	,	,	,
cord-296585-yfh5d4io	97	15	firstly	firstly	RB
cord-296585-yfh5d4io	97	16	,	,	,
cord-296585-yfh5d4io	97	17	chromatin	chromatin	NN
cord-296585-yfh5d4io	97	18	remodeling	remodeling	NN
cord-296585-yfh5d4io	97	19	(	(	-LRB-
cord-296585-yfh5d4io	97	20	Left	left	NN
cord-296585-yfh5d4io	97	21	)	)	-RRB-
cord-296585-yfh5d4io	97	22	and	and	CC
cord-296585-yfh5d4io	97	23	secondly	secondly	RB
cord-296585-yfh5d4io	97	24	,	,	,
cord-296585-yfh5d4io	97	25	DNA	dna	NN
cord-296585-yfh5d4io	97	26	methylation	methylation	NN
cord-296585-yfh5d4io	97	27	(	(	-LRB-
cord-296585-yfh5d4io	97	28	Right	right	UH
cord-296585-yfh5d4io	97	29	)	)	-RRB-
cord-296585-yfh5d4io	97	30	.	.	.
cord-296585-yfh5d4io	98	1	Chromatin	Chromatin	NNP
cord-296585-yfh5d4io	98	2	remodeling	remodeling	NN
cord-296585-yfh5d4io	98	3	involves	involve	VBZ
cord-296585-yfh5d4io	98	4	activation	activation	NN
cord-296585-yfh5d4io	98	5	of	of	IN
cord-296585-yfh5d4io	98	6	kinases	kinase	NNS
cord-296585-yfh5d4io	98	7	signaling	signal	VBG
cord-296585-yfh5d4io	98	8	pathways	pathway	NNS
cord-296585-yfh5d4io	98	9	,	,	,
cord-296585-yfh5d4io	98	10	activation	activation	NN
cord-296585-yfh5d4io	98	11	and	and	CC
cord-296585-yfh5d4io	98	12	nuclear	nuclear	JJ
cord-296585-yfh5d4io	98	13	translocation	translocation	NN
cord-296585-yfh5d4io	98	14	of	of	IN
cord-296585-yfh5d4io	98	15	transcription	transcription	NN
cord-296585-yfh5d4io	98	16	factor	factor	NN
cord-296585-yfh5d4io	98	17	NF	nf	NN
cord-296585-yfh5d4io	98	18	-	-	HYPH
cord-296585-yfh5d4io	98	19	κB	κB	NNP
cord-296585-yfh5d4io	99	1	(	(	-LRB-
cord-296585-yfh5d4io	99	2	RelA	RelA	NNP
cord-296585-yfh5d4io	99	3	/	/	SYM
cord-296585-yfh5d4io	99	4	p65	p65	NN
cord-296585-yfh5d4io	99	5	)	)	-RRB-
cord-296585-yfh5d4io	99	6	,	,	,
cord-296585-yfh5d4io	99	7	and	and	CC
cord-296585-yfh5d4io	99	8	complex	complex	JJ
cord-296585-yfh5d4io	99	9	formation	formation	NN
cord-296585-yfh5d4io	99	10	with	with	IN
cord-296585-yfh5d4io	99	11	CBP	CBP	NNP
cord-296585-yfh5d4io	99	12	/	/	SYM
cord-296585-yfh5d4io	99	13	p300	p300	NNP
cord-296585-yfh5d4io	99	14	on	on	IN
cord-296585-yfh5d4io	99	15	specific	specific	JJ
cord-296585-yfh5d4io	99	16	DNA	dna	NN
cord-296585-yfh5d4io	99	17	sites	site	NNS
cord-296585-yfh5d4io	99	18	.	.	.
cord-296585-yfh5d4io	100	1	CBP	CBP	NNP
cord-296585-yfh5d4io	100	2	/	/	SYM
cord-296585-yfh5d4io	100	3	p300	p300	NNP
cord-296585-yfh5d4io	100	4	is	be	VBZ
cord-296585-yfh5d4io	100	5	intrinsically	intrinsically	RB
cord-296585-yfh5d4io	100	6	a	a	DT
cord-296585-yfh5d4io	100	7	histone	histone	NN
cord-296585-yfh5d4io	100	8	acetyltransferase	acetyltransferase	NN
cord-296585-yfh5d4io	100	9	(	(	-LRB-
cord-296585-yfh5d4io	100	10	HAT	hat	NN
cord-296585-yfh5d4io	100	11	)	)	-RRB-
cord-296585-yfh5d4io	100	12	.	.	.
cord-296585-yfh5d4io	101	1	Subunit	subunit	NN
cord-296585-yfh5d4io	101	2	p65	p65	NN
cord-296585-yfh5d4io	101	3	is	be	VBZ
cord-296585-yfh5d4io	101	4	further	far	RBR
cord-296585-yfh5d4io	101	5	phosphorylated	phosphorylate	VBN
cord-296585-yfh5d4io	101	6	at	at	IN
cord-296585-yfh5d4io	101	7	Ser276	ser276	CD
cord-296585-yfh5d4io	102	1	and	and	CC
cord-296585-yfh5d4io	102	2	Ser311	ser311	NN
cord-296585-yfh5d4io	102	3	,	,	,
cord-296585-yfh5d4io	102	4	respectively	respectively	RB
cord-296585-yfh5d4io	102	5	,	,	,
cord-296585-yfh5d4io	102	6	by	by	IN
cord-296585-yfh5d4io	102	7	MSK1	MSK1	NNP
cord-296585-yfh5d4io	102	8	and	and	CC
cord-296585-yfh5d4io	102	9	PKCζ	PKCζ	NNS
cord-296585-yfh5d4io	102	10	,	,	,
cord-296585-yfh5d4io	102	11	whereas	whereas	IN
cord-296585-yfh5d4io	102	12	CBP	CBP	NNP
cord-296585-yfh5d4io	102	13	acetylates	acetylate	NNS
cord-296585-yfh5d4io	102	14	p65	p65	VBP
cord-296585-yfh5d4io	102	15	at	at	IN
cord-296585-yfh5d4io	102	16	Lys310	lys310	CD
cord-296585-yfh5d4io	102	17	.	.	.
cord-296585-yfh5d4io	103	1	The	the	DT
cord-296585-yfh5d4io	103	2	phosphorylation	phosphorylation	NN
cord-296585-yfh5d4io	103	3	and	and	CC
cord-296585-yfh5d4io	103	4	acetylation	acetylation	NN
cord-296585-yfh5d4io	103	5	enhance	enhance	VBP
cord-296585-yfh5d4io	103	6	the	the	DT
cord-296585-yfh5d4io	103	7	interaction	interaction	NN
cord-296585-yfh5d4io	103	8	within	within	IN
cord-296585-yfh5d4io	103	9	the	the	DT
cord-296585-yfh5d4io	103	10	NF	nf	NN
cord-296585-yfh5d4io	103	11	-	-	HYPH
cord-296585-yfh5d4io	103	12	κB	κB	NNP
cord-296585-yfh5d4io	103	13	/	/	SYM
cord-296585-yfh5d4io	103	14	CBP	CBP	NNP
cord-296585-yfh5d4io	103	15	/	/	SYM
cord-296585-yfh5d4io	103	16	p300	p300	NNP
cord-296585-yfh5d4io	103	17	complex	complex	NN
cord-296585-yfh5d4io	103	18	while	while	IN
cord-296585-yfh5d4io	103	19	stabilizing	stabilize	VBG
cord-296585-yfh5d4io	103	20	the	the	DT
cord-296585-yfh5d4io	103	21	DNA	dna	NN
cord-296585-yfh5d4io	103	22	binding	binding	NN
cord-296585-yfh5d4io	103	23	of	of	IN
cord-296585-yfh5d4io	103	24	NF	nf	NN
cord-296585-yfh5d4io	103	25	-	-	HYPH
cord-296585-yfh5d4io	103	26	κB.	κb.	JJ
cord-296585-yfh5d4io	104	1	The	the	DT
cord-296585-yfh5d4io	104	2	complex	complex	NN
cord-296585-yfh5d4io	104	3	of	of	IN
cord-296585-yfh5d4io	104	4	NF	nf	NN
cord-296585-yfh5d4io	104	5	-	-	HYPH
cord-296585-yfh5d4io	104	6	κB	κB	NNP
cord-296585-yfh5d4io	104	7	/	/	SYM
cord-296585-yfh5d4io	104	8	CBP	CBP	NNP
cord-296585-yfh5d4io	104	9	/	/	SYM
cord-296585-yfh5d4io	104	10	p300	p300	NNP
cord-296585-yfh5d4io	104	11	then	then	RB
cord-296585-yfh5d4io	104	12	modifies	modify	VBZ
cord-296585-yfh5d4io	104	13	the	the	DT
cord-296585-yfh5d4io	104	14	histones	histone	NNS
cord-296585-yfh5d4io	104	15	through	through	IN
cord-296585-yfh5d4io	104	16	CBP	CBP	NNP
cord-296585-yfh5d4io	104	17	-	-	HYPH
cord-296585-yfh5d4io	104	18	mediated	mediate	VBN
cord-296585-yfh5d4io	104	19	acetylations	acetylation	NNS
cord-296585-yfh5d4io	104	20	of	of	IN
cord-296585-yfh5d4io	104	21	histone	histone	NN
cord-296585-yfh5d4io	104	22	H3	H3	NNP
cord-296585-yfh5d4io	104	23	(	(	-LRB-
cord-296585-yfh5d4io	104	24	at	at	IN
cord-296585-yfh5d4io	104	25	Lys9	Lys9	NNP
cord-296585-yfh5d4io	104	26	)	)	-RRB-
cord-296585-yfh5d4io	104	27	and	and	CC
cord-296585-yfh5d4io	104	28	H4	H4	NNP
cord-296585-yfh5d4io	104	29	at	at	IN
cord-296585-yfh5d4io	104	30	Lys	Lys	NNP
cord-296585-yfh5d4io	104	31	8	8	CD
cord-296585-yfh5d4io	104	32	and	and	CC
cord-296585-yfh5d4io	104	33	Lys12	Lys12	NNP
cord-296585-yfh5d4io	104	34	,	,	,
cord-296585-yfh5d4io	104	35	and	and	CC
cord-296585-yfh5d4io	104	36	phosphorylation	phosphorylation	NN
cord-296585-yfh5d4io	104	37	of	of	IN
cord-296585-yfh5d4io	104	38	H3	H3	NNP
cord-296585-yfh5d4io	104	39	at	at	IN
cord-296585-yfh5d4io	104	40	Ser10	Ser10	NNP
cord-296585-yfh5d4io	104	41	by	by	IN
cord-296585-yfh5d4io	104	42	MSK1	MSK1	NNP
cord-296585-yfh5d4io	104	43	and	and	CC
cord-296585-yfh5d4io	104	44	PKCζ	PKCζ	NNS
cord-296585-yfh5d4io	104	45	.	.	.
cord-296585-yfh5d4io	105	1	This	this	DT
cord-296585-yfh5d4io	105	2	results	result	VBZ
cord-296585-yfh5d4io	105	3	in	in	IN
cord-296585-yfh5d4io	105	4	the	the	DT
cord-296585-yfh5d4io	105	5	structure	structure	NN
cord-296585-yfh5d4io	105	6	change	change	NN
cord-296585-yfh5d4io	105	7	of	of	IN
cord-296585-yfh5d4io	105	8	chromatin	chromatin	NN
cord-296585-yfh5d4io	105	9	,	,	,
cord-296585-yfh5d4io	105	10	from	from	IN
cord-296585-yfh5d4io	105	11	a	a	DT
cord-296585-yfh5d4io	105	12	condensed	condense	VBN
cord-296585-yfh5d4io	105	13	structure	structure	NN
cord-296585-yfh5d4io	105	14	(	(	-LRB-
cord-296585-yfh5d4io	105	15	repressed	repress	VBN
cord-296585-yfh5d4io	105	16	)	)	-RRB-
cord-296585-yfh5d4io	105	17	to	to	IN
cord-296585-yfh5d4io	105	18	an	an	DT
cord-296585-yfh5d4io	105	19	activated	activate	VBN
cord-296585-yfh5d4io	105	20	open	open	JJ
cord-296585-yfh5d4io	105	21	conformation	conformation	NN
cord-296585-yfh5d4io	105	22	.	.	.
cord-296585-yfh5d4io	106	1	The	the	DT
cord-296585-yfh5d4io	106	2	transcription	transcription	NN
cord-296585-yfh5d4io	106	3	of	of	IN
cord-296585-yfh5d4io	106	4	target	target	NN
cord-296585-yfh5d4io	106	5	genes	gene	NNS
cord-296585-yfh5d4io	106	6	is	be	VBZ
cord-296585-yfh5d4io	106	7	therefore	therefore	RB
cord-296585-yfh5d4io	106	8	increased	increase	VBN
cord-296585-yfh5d4io	106	9	.	.	.
cord-296585-yfh5d4io	107	1	In	in	IN
cord-296585-yfh5d4io	107	2	the	the	DT
cord-296585-yfh5d4io	107	3	second	second	JJ
cord-296585-yfh5d4io	107	4	mechanism	mechanism	NN
cord-296585-yfh5d4io	107	5	,	,	,
cord-296585-yfh5d4io	107	6	several	several	JJ
cord-296585-yfh5d4io	107	7	side	side	NN
cord-296585-yfh5d4io	107	8	effects	effect	NNS
cord-296585-yfh5d4io	107	9	resulting	result	VBG
cord-296585-yfh5d4io	107	10	from	from	IN
cord-296585-yfh5d4io	107	11	cigarette	cigarette	NN
cord-296585-yfh5d4io	107	12	smoking	smoking	NN
cord-296585-yfh5d4io	107	13	such	such	JJ
cord-296585-yfh5d4io	107	14	as	as	IN
cord-296585-yfh5d4io	107	15	DNA	dna	NN
cord-296585-yfh5d4io	107	16	damage	damage	NN
cord-296585-yfh5d4io	107	17	and	and	CC
cord-296585-yfh5d4io	107	18	nicotine	nicotine	NN
cord-296585-yfh5d4io	107	19	signaling	signaling	NN
cord-296585-yfh5d4io	107	20	could	could	MD
cord-296585-yfh5d4io	107	21	trigger	trigger	VB
cord-296585-yfh5d4io	107	22	the	the	DT
cord-296585-yfh5d4io	107	23	hypermethylation	hypermethylation	NN
cord-296585-yfh5d4io	107	24	or	or	CC
cord-296585-yfh5d4io	107	25	decreased	decrease	VBD
cord-296585-yfh5d4io	107	26	methylation	methylation	NN
cord-296585-yfh5d4io	107	27	of	of	IN
cord-296585-yfh5d4io	107	28	target	target	NN
cord-296585-yfh5d4io	107	29	DNA	dna	NN
cord-296585-yfh5d4io	107	30	.	.	.
cord-296585-yfh5d4io	108	1	This	this	DT
cord-296585-yfh5d4io	108	2	may	may	MD
cord-296585-yfh5d4io	108	3	lead	lead	VB
cord-296585-yfh5d4io	108	4	to	to	IN
cord-296585-yfh5d4io	108	5	DNA	dna	NN
cord-296585-yfh5d4io	108	6	methylation	methylation	NN
cord-296585-yfh5d4io	108	7	anomalies	anomaly	NNS
cord-296585-yfh5d4io	108	8	and	and	CC
cord-296585-yfh5d4io	108	9	thus	thus	RB
cord-296585-yfh5d4io	108	10	altered	alter	VBN
cord-296585-yfh5d4io	108	11	DNA	dna	NN
cord-296585-yfh5d4io	108	12	expression	expression	NN
cord-296585-yfh5d4io	108	13	.	.	.
cord-296585-yfh5d4io	109	1	Resulting	result	VBG
cord-296585-yfh5d4io	109	2	hypoxia	hypoxia	NN
cord-296585-yfh5d4io	109	3	due	due	IN
cord-296585-yfh5d4io	109	4	to	to	IN
cord-296585-yfh5d4io	109	5	high	high	JJ
cord-296585-yfh5d4io	109	6	concentrations	concentration	NNS
cord-296585-yfh5d4io	109	7	of	of	IN
cord-296585-yfh5d4io	109	8	carbon	carbon	NN
cord-296585-yfh5d4io	109	9	monoxide	monoxide	NN
cord-296585-yfh5d4io	109	10	also	also	RB
cord-296585-yfh5d4io	109	11	contributes	contribute	VBZ
cord-296585-yfh5d4io	109	12	to	to	IN
cord-296585-yfh5d4io	109	13	altered	alter	VBN
cord-296585-yfh5d4io	109	14	gene	gene	NN
cord-296585-yfh5d4io	109	15	expression	expression	NN
cord-296585-yfh5d4io	109	16	.	.	.
cord-296585-yfh5d4io	110	1	The	the	DT
cord-296585-yfh5d4io	110	2	aberrant	aberrant	JJ
cord-296585-yfh5d4io	110	3	gene	gene	NN
cord-296585-yfh5d4io	110	4	expression	expression	NN
cord-296585-yfh5d4io	110	5	by	by	IN
cord-296585-yfh5d4io	110	6	cigarette	cigarette	NN
cord-296585-yfh5d4io	110	7	smoke	smoke	NN
cord-296585-yfh5d4io	110	8	mostly	mostly	RB
cord-296585-yfh5d4io	110	9	occurs	occur	VBZ
cord-296585-yfh5d4io	110	10	in	in	IN
cord-296585-yfh5d4io	110	11	pro	pro	JJ
cord-296585-yfh5d4io	110	12	-	-	JJ
cord-296585-yfh5d4io	110	13	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	110	14	genes	gene	NNS
cord-296585-yfh5d4io	110	15	with	with	IN
cord-296585-yfh5d4io	110	16	resulting	result	VBG
cord-296585-yfh5d4io	110	17	increased	increase	VBN
cord-296585-yfh5d4io	110	18	production	production	NN
cord-296585-yfh5d4io	110	19	of	of	IN
cord-296585-yfh5d4io	110	20	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	110	21	mediators	mediator	NNS
cord-296585-yfh5d4io	110	22	,	,	,
cord-296585-yfh5d4io	110	23	and	and	CC
cord-296585-yfh5d4io	110	24	amplified	amplify	VBD
cord-296585-yfh5d4io	110	25	inflammation	inflammation	NN
cord-296585-yfh5d4io	110	26	in	in	IN
cord-296585-yfh5d4io	110	27	the	the	DT
cord-296585-yfh5d4io	110	28	COPD	COPD	NNP
cord-296585-yfh5d4io	110	29	lung	lung	NN
cord-296585-yfh5d4io	110	30	upon	upon	IN
cord-296585-yfh5d4io	110	31	exposure	exposure	NN
cord-296585-yfh5d4io	110	32	.	.	.
cord-296585-yfh5d4io	111	1	irregular	irregular	JJ
cord-296585-yfh5d4io	111	2	gene	gene	NN
cord-296585-yfh5d4io	111	3	expression	expression	NN
cord-296585-yfh5d4io	111	4	by	by	IN
cord-296585-yfh5d4io	111	5	various	various	JJ
cord-296585-yfh5d4io	111	6	cell	cell	NN
cord-296585-yfh5d4io	111	7	types	type	NNS
cord-296585-yfh5d4io	111	8	in	in	IN
cord-296585-yfh5d4io	111	9	the	the	DT
cord-296585-yfh5d4io	111	10	airway	airway	NN
cord-296585-yfh5d4io	111	11	.	.	.
cord-296585-yfh5d4io	112	1	The	the	DT
cord-296585-yfh5d4io	112	2	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	112	3	reported	report	VBN
cord-296585-yfh5d4io	112	4	are	be	VBP
cord-296585-yfh5d4io	112	5	responsible	responsible	JJ
cord-296585-yfh5d4io	112	6	for	for	IN
cord-296585-yfh5d4io	112	7	increased	increase	VBN
cord-296585-yfh5d4io	112	8	expression	expression	NN
cord-296585-yfh5d4io	112	9	of	of	IN
cord-296585-yfh5d4io	112	10	NF	nf	NN
cord-296585-yfh5d4io	112	11	-	-	HYPH
cord-296585-yfh5d4io	112	12	κB	κB	NNP
cord-296585-yfh5d4io	112	13	-	-	HYPH
cord-296585-yfh5d4io	112	14	dependent	dependent	JJ
cord-296585-yfh5d4io	112	15	proinflammatory	proinflammatory	JJ
cord-296585-yfh5d4io	112	16	gene	gene	NN
cord-296585-yfh5d4io	112	17	products	product	NNS
cord-296585-yfh5d4io	112	18	[	[	-LRB-
cord-296585-yfh5d4io	112	19	i.e.	i.e.	FW
cord-296585-yfh5d4io	112	20	,	,	,
cord-296585-yfh5d4io	112	21	IL-1β	il-1β	ADD
cord-296585-yfh5d4io	112	22	,	,	,
cord-296585-yfh5d4io	112	23	IL-6	IL-6	NNP
cord-296585-yfh5d4io	112	24	,	,	,
cord-296585-yfh5d4io	112	25	IL-8	IL-8	NNP
cord-296585-yfh5d4io	112	26	,	,	,
cord-296585-yfh5d4io	112	27	CCL-5	CCL-5	NNP
cord-296585-yfh5d4io	112	28	cyclooxygenase	cyclooxygenase	NN
cord-296585-yfh5d4io	112	29	(	(	-LRB-
cord-296585-yfh5d4io	112	30	COX)-2	COX)-2	NNP
cord-296585-yfh5d4io	112	31	,	,	,
cord-296585-yfh5d4io	112	32	and	and	CC
cord-296585-yfh5d4io	112	33	MIP-2	MIP-2	NNP
cord-296585-yfh5d4io	112	34	/	/	SYM
cord-296585-yfh5d4io	112	35	CXCL2	cxcl2	NN
cord-296585-yfh5d4io	112	36	]	]	-RRB-
cord-296585-yfh5d4io	112	37	in	in	IN
cord-296585-yfh5d4io	112	38	both	both	DT
cord-296585-yfh5d4io	112	39	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	112	40	structural	structural	JJ
cord-296585-yfh5d4io	112	41	cells	cell	NNS
cord-296585-yfh5d4io	112	42	(	(	-LRB-
cord-296585-yfh5d4io	112	43	bronchial	bronchial	JJ
cord-296585-yfh5d4io	112	44	,	,	,
cord-296585-yfh5d4io	112	45	small	small	JJ
cord-296585-yfh5d4io	112	46	airway	airway	NN
cord-296585-yfh5d4io	112	47	,	,	,
cord-296585-yfh5d4io	112	48	and	and	CC
cord-296585-yfh5d4io	112	49	alveolar	alveolar	JJ
cord-296585-yfh5d4io	112	50	epithelial	epithelial	JJ
cord-296585-yfh5d4io	112	51	cells	cell	NNS
cord-296585-yfh5d4io	112	52	)	)	-RRB-
cord-296585-yfh5d4io	112	53	and	and	CC
cord-296585-yfh5d4io	112	54	immune	immune	JJ
cord-296585-yfh5d4io	112	55	cells	cell	NNS
cord-296585-yfh5d4io	112	56	(	(	-LRB-
cord-296585-yfh5d4io	112	57	alveolar	alveolar	JJ
cord-296585-yfh5d4io	112	58	macrophages	macrophage	NNS
cord-296585-yfh5d4io	112	59	)	)	-RRB-
cord-296585-yfh5d4io	112	60	,	,	,
cord-296585-yfh5d4io	112	61	increased	increase	VBD
cord-296585-yfh5d4io	112	62	VEGF	VEGF	NNP
cord-296585-yfh5d4io	112	63	and	and	CC
cord-296585-yfh5d4io	112	64	iNOS	ino	VBD
cord-296585-yfh5d4io	112	65	in	in	IN
cord-296585-yfh5d4io	112	66	nasal	nasal	NN
cord-296585-yfh5d4io	112	67	fibroblasts	fibroblast	NNS
cord-296585-yfh5d4io	112	68	and	and	CC
cord-296585-yfh5d4io	112	69	lymphocytes	lymphocyte	NNS
cord-296585-yfh5d4io	112	70	(	(	-LRB-
cord-296585-yfh5d4io	112	71	Jurkat	Jurkat	NNP
cord-296585-yfh5d4io	112	72	T	T	NNP
cord-296585-yfh5d4io	112	73	cells	cell	NNS
cord-296585-yfh5d4io	112	74	)	)	-RRB-
cord-296585-yfh5d4io	112	75	,	,	,
cord-296585-yfh5d4io	112	76	respectively	respectively	RB
cord-296585-yfh5d4io	112	77	,	,	,
cord-296585-yfh5d4io	112	78	and	and	CC
cord-296585-yfh5d4io	112	79	decreased	decrease	VBD
cord-296585-yfh5d4io	112	80	activity	activity	NN
cord-296585-yfh5d4io	112	81	of	of	IN
cord-296585-yfh5d4io	112	82	antioxidant	antioxidant	JJ
cord-296585-yfh5d4io	112	83	transcription	transcription	NN
cord-296585-yfh5d4io	112	84	factor	factor	NN
cord-296585-yfh5d4io	112	85	Nrf2	Nrf2	NNP
cord-296585-yfh5d4io	112	86	and	and	CC
cord-296585-yfh5d4io	112	87	α1-antitrypsin	α1-antitrypsin	NNS
cord-296585-yfh5d4io	112	88	in	in	IN
cord-296585-yfh5d4io	112	89	bronchial	bronchial	JJ
cord-296585-yfh5d4io	112	90	epithelial	epithelial	JJ
cord-296585-yfh5d4io	112	91	cells	cell	NNS
cord-296585-yfh5d4io	112	92	(	(	-LRB-
cord-296585-yfh5d4io	112	93	54	54	CD
cord-296585-yfh5d4io	112	94	,	,	,
cord-296585-yfh5d4io	112	95	56	56	CD
cord-296585-yfh5d4io	112	96	,	,	,
cord-296585-yfh5d4io	112	97	57	57	CD
cord-296585-yfh5d4io	112	98	,	,	,
cord-296585-yfh5d4io	112	99	59	59	CD
cord-296585-yfh5d4io	112	100	,	,	,
cord-296585-yfh5d4io	112	101	62	62	CD
cord-296585-yfh5d4io	112	102	-	-	SYM
cord-296585-yfh5d4io	112	103	64	64	CD
cord-296585-yfh5d4io	112	104	,	,	,
cord-296585-yfh5d4io	112	105	[	[	-LRB-
cord-296585-yfh5d4io	112	106	72	72	CD
cord-296585-yfh5d4io	112	107	]	]	-RRB-
cord-296585-yfh5d4io	112	108	[	[	-LRB-
cord-296585-yfh5d4io	112	109	73	73	CD
cord-296585-yfh5d4io	112	110	]	]	-RRB-
cord-296585-yfh5d4io	112	111	[	[	-LRB-
cord-296585-yfh5d4io	112	112	74	74	CD
cord-296585-yfh5d4io	112	113	]	]	-RRB-
cord-296585-yfh5d4io	112	114	[	[	-LRB-
cord-296585-yfh5d4io	112	115	75	75	CD
cord-296585-yfh5d4io	112	116	]	]	-RRB-
cord-296585-yfh5d4io	112	117	[	[	-LRB-
cord-296585-yfh5d4io	112	118	76	76	CD
cord-296585-yfh5d4io	112	119	]	]	-RRB-
cord-296585-yfh5d4io	112	120	[	[	-LRB-
cord-296585-yfh5d4io	112	121	77	77	CD
cord-296585-yfh5d4io	112	122	]	]	-RRB-
cord-296585-yfh5d4io	112	123	[	[	-LRB-
cord-296585-yfh5d4io	112	124	78	78	CD
cord-296585-yfh5d4io	112	125	]	]	-RRB-
cord-296585-yfh5d4io	112	126	[	[	-LRB-
cord-296585-yfh5d4io	112	127	79	79	CD
cord-296585-yfh5d4io	112	128	]	]	-RRB-
cord-296585-yfh5d4io	112	129	.	.	.
cord-296585-yfh5d4io	113	1	These	these	DT
cord-296585-yfh5d4io	113	2	may	may	MD
cord-296585-yfh5d4io	113	3	contribute	contribute	VB
cord-296585-yfh5d4io	113	4	to	to	IN
cord-296585-yfh5d4io	113	5	the	the	DT
cord-296585-yfh5d4io	113	6	anatomical	anatomical	JJ
cord-296585-yfh5d4io	113	7	anomalies	anomaly	NNS
cord-296585-yfh5d4io	113	8	in	in	IN
cord-296585-yfh5d4io	113	9	the	the	DT
cord-296585-yfh5d4io	113	10	airway	airway	NN
cord-296585-yfh5d4io	113	11	and	and	CC
cord-296585-yfh5d4io	113	12	excessive	excessive	JJ
cord-296585-yfh5d4io	113	13	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	113	14	responses	response	NNS
cord-296585-yfh5d4io	113	15	among	among	IN
cord-296585-yfh5d4io	113	16	smokers	smoker	NNS
cord-296585-yfh5d4io	113	17	during	during	IN
cord-296585-yfh5d4io	113	18	the	the	DT
cord-296585-yfh5d4io	113	19	course	course	NN
cord-296585-yfh5d4io	113	20	of	of	IN
cord-296585-yfh5d4io	113	21	COPD	COPD	NNP
cord-296585-yfh5d4io	113	22	.	.	.
cord-296585-yfh5d4io	114	1	COPD	COPD	NNP
cord-296585-yfh5d4io	114	2	is	be	VBZ
cord-296585-yfh5d4io	114	3	associated	associate	VBN
cord-296585-yfh5d4io	114	4	with	with	IN
cord-296585-yfh5d4io	114	5	chronic	chronic	JJ
cord-296585-yfh5d4io	114	6	inflammation	inflammation	NN
cord-296585-yfh5d4io	114	7	in	in	IN
cord-296585-yfh5d4io	114	8	the	the	DT
cord-296585-yfh5d4io	114	9	peripheral	peripheral	JJ
cord-296585-yfh5d4io	114	10	airways	airway	NNS
cord-296585-yfh5d4io	114	11	orchestrated	orchestrate	VBN
cord-296585-yfh5d4io	114	12	by	by	IN
cord-296585-yfh5d4io	114	13	both	both	DT
cord-296585-yfh5d4io	114	14	innate	innate	JJ
cord-296585-yfh5d4io	114	15	and	and	CC
cord-296585-yfh5d4io	114	16	adaptive	adaptive	JJ
cord-296585-yfh5d4io	114	17	immune	immune	JJ
cord-296585-yfh5d4io	114	18	responses	response	NNS
cord-296585-yfh5d4io	114	19	that	that	WDT
cord-296585-yfh5d4io	114	20	are	be	VBP
cord-296585-yfh5d4io	114	21	interconnected	interconnect	VBN
cord-296585-yfh5d4io	114	22	via	via	IN
cord-296585-yfh5d4io	114	23	dendritic	dendritic	JJ
cord-296585-yfh5d4io	114	24	cells	cell	NNS
cord-296585-yfh5d4io	114	25	(	(	-LRB-
cord-296585-yfh5d4io	114	26	80	80	CD
cord-296585-yfh5d4io	114	27	)	)	-RRB-
cord-296585-yfh5d4io	114	28	.	.	.
cord-296585-yfh5d4io	115	1	Increasing	increase	VBG
cord-296585-yfh5d4io	115	2	numbers	number	NNS
cord-296585-yfh5d4io	115	3	of	of	IN
cord-296585-yfh5d4io	115	4	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	115	5	cells	cell	NNS
cord-296585-yfh5d4io	115	6	(	(	-LRB-
cord-296585-yfh5d4io	115	7	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	115	8	,	,	,
cord-296585-yfh5d4io	115	9	macrophages	macrophage	NNS
cord-296585-yfh5d4io	115	10	,	,	,
cord-296585-yfh5d4io	115	11	T	T	NNP
cord-296585-yfh5d4io	115	12	and	and	CC
cord-296585-yfh5d4io	115	13	B	b	NN
cord-296585-yfh5d4io	115	14	lymphocytes	lymphocyte	NNS
cord-296585-yfh5d4io	115	15	,	,	,
cord-296585-yfh5d4io	115	16	mast	mast	NN
cord-296585-yfh5d4io	115	17	cell	cell	NN
cord-296585-yfh5d4io	115	18	,	,	,
cord-296585-yfh5d4io	115	19	eosinophils	eosinophil	NNS
cord-296585-yfh5d4io	115	20	,	,	,
cord-296585-yfh5d4io	115	21	and	and	CC
cord-296585-yfh5d4io	115	22	dendritic	dendritic	JJ
cord-296585-yfh5d4io	115	23	cells	cell	NNS
cord-296585-yfh5d4io	115	24	)	)	-RRB-
cord-296585-yfh5d4io	115	25	and	and	CC
cord-296585-yfh5d4io	115	26	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	115	27	mediators	mediator	NNS
cord-296585-yfh5d4io	115	28	are	be	VBP
cord-296585-yfh5d4io	115	29	accumulated	accumulate	VBN
cord-296585-yfh5d4io	115	30	in	in	IN
cord-296585-yfh5d4io	115	31	the	the	DT
cord-296585-yfh5d4io	115	32	airway	airway	NN
cord-296585-yfh5d4io	115	33	lumen	lumen	NNP
cord-296585-yfh5d4io	115	34	/	/	SYM
cord-296585-yfh5d4io	115	35	wall	wall	NN
cord-296585-yfh5d4io	115	36	in	in	IN
cord-296585-yfh5d4io	115	37	the	the	DT
cord-296585-yfh5d4io	115	38	lung	lung	NN
cord-296585-yfh5d4io	115	39	parenchyma	parenchyma	NN
cord-296585-yfh5d4io	115	40	(	(	-LRB-
cord-296585-yfh5d4io	115	41	19	19	CD
cord-296585-yfh5d4io	115	42	,	,	,
cord-296585-yfh5d4io	115	43	81	81	CD
cord-296585-yfh5d4io	115	44	)	)	-RRB-
cord-296585-yfh5d4io	115	45	.	.	.
cord-296585-yfh5d4io	116	1	These	these	DT
cord-296585-yfh5d4io	116	2	immune	immune	JJ
cord-296585-yfh5d4io	116	3	cells	cell	NNS
cord-296585-yfh5d4io	116	4	and	and	CC
cord-296585-yfh5d4io	116	5	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	116	6	mediators	mediator	NNS
cord-296585-yfh5d4io	116	7	can	can	MD
cord-296585-yfh5d4io	116	8	hence	hence	RB
cord-296585-yfh5d4io	116	9	be	be	VB
cord-296585-yfh5d4io	116	10	detected	detect	VBN
cord-296585-yfh5d4io	116	11	in	in	IN
cord-296585-yfh5d4io	116	12	the	the	DT
cord-296585-yfh5d4io	116	13	sputum	sputum	NN
cord-296585-yfh5d4io	116	14	and	and	CC
cord-296585-yfh5d4io	116	15	BAL	bal	NN
cord-296585-yfh5d4io	116	16	fluid	fluid	NN
cord-296585-yfh5d4io	116	17	of	of	IN
cord-296585-yfh5d4io	116	18	COPD	COPD	NNP
cord-296585-yfh5d4io	116	19	patients	patient	NNS
cord-296585-yfh5d4io	116	20	.	.	.
cord-296585-yfh5d4io	117	1	The	the	DT
cord-296585-yfh5d4io	117	2	level	level	NN
cord-296585-yfh5d4io	117	3	of	of	IN
cord-296585-yfh5d4io	117	4	accumulation	accumulation	NN
cord-296585-yfh5d4io	117	5	is	be	VBZ
cord-296585-yfh5d4io	117	6	positively	positively	RB
cord-296585-yfh5d4io	117	7	correlated	correlate	VBN
cord-296585-yfh5d4io	117	8	with	with	IN
cord-296585-yfh5d4io	117	9	disease	disease	NN
cord-296585-yfh5d4io	117	10	severity	severity	NN
cord-296585-yfh5d4io	117	11	.	.	.
cord-296585-yfh5d4io	118	1	An	an	DT
cord-296585-yfh5d4io	118	2	increasing	increase	VBG
cord-296585-yfh5d4io	118	3	number	number	NN
cord-296585-yfh5d4io	118	4	of	of	IN
cord-296585-yfh5d4io	118	5	studies	study	NNS
cord-296585-yfh5d4io	118	6	using	use	VBG
cord-296585-yfh5d4io	118	7	animal	animal	NN
cord-296585-yfh5d4io	118	8	models	model	NNS
cord-296585-yfh5d4io	118	9	and	and	CC
cord-296585-yfh5d4io	118	10	clinical	clinical	JJ
cord-296585-yfh5d4io	118	11	tissues	tissue	NNS
cord-296585-yfh5d4io	118	12	have	have	VBP
cord-296585-yfh5d4io	118	13	reported	report	VBN
cord-296585-yfh5d4io	118	14	the	the	DT
cord-296585-yfh5d4io	118	15	nature	nature	NN
cord-296585-yfh5d4io	118	16	of	of	IN
cord-296585-yfh5d4io	118	17	excessive	excessive	JJ
cord-296585-yfh5d4io	118	18	airway	airway	JJ
cord-296585-yfh5d4io	118	19	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	118	20	responses	response	NNS
cord-296585-yfh5d4io	118	21	in	in	IN
cord-296585-yfh5d4io	118	22	COPD	COPD	NNP
cord-296585-yfh5d4io	118	23	.	.	.
cord-296585-yfh5d4io	119	1	Despite	despite	IN
cord-296585-yfh5d4io	119	2	this	this	DT
cord-296585-yfh5d4io	119	3	,	,	,
cord-296585-yfh5d4io	119	4	the	the	DT
cord-296585-yfh5d4io	119	5	heterogeneity	heterogeneity	NN
cord-296585-yfh5d4io	119	6	in	in	IN
cord-296585-yfh5d4io	119	7	symptoms	symptom	NNS
cord-296585-yfh5d4io	119	8	progression	progression	NN
cord-296585-yfh5d4io	119	9	among	among	IN
cord-296585-yfh5d4io	119	10	COPD	COPD	NNP
cord-296585-yfh5d4io	119	11	patients	patient	NNS
cord-296585-yfh5d4io	119	12	remain	remain	VBP
cord-296585-yfh5d4io	119	13	unexplained	unexplained	JJ
cord-296585-yfh5d4io	119	14	.	.	.
cord-296585-yfh5d4io	120	1	The	the	DT
cord-296585-yfh5d4io	120	2	overall	overall	JJ
cord-296585-yfh5d4io	120	3	mechanism	mechanism	NN
cord-296585-yfh5d4io	120	4	of	of	IN
cord-296585-yfh5d4io	120	5	COPD	COPD	NNP
cord-296585-yfh5d4io	120	6	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	120	7	immune	immune	JJ
cord-296585-yfh5d4io	120	8	response	response	NN
cord-296585-yfh5d4io	120	9	is	be	VBZ
cord-296585-yfh5d4io	120	10	depicted	depict	VBN
cord-296585-yfh5d4io	120	11	in	in	IN
cord-296585-yfh5d4io	120	12	Figure	figure	NN
cord-296585-yfh5d4io	120	13	2	2	CD
cord-296585-yfh5d4io	120	14	.	.	.
cord-296585-yfh5d4io	121	1	The	the	DT
cord-296585-yfh5d4io	121	2	First	first	JJ
cord-296585-yfh5d4io	121	3	Line	Line	NNP
cord-296585-yfh5d4io	121	4	of	of	IN
cord-296585-yfh5d4io	121	5	Defense	Defense	NNP
cord-296585-yfh5d4io	121	6	in	in	IN
cord-296585-yfh5d4io	121	7	the	the	DT
cord-296585-yfh5d4io	121	8	Lung	Lung	NNP
cord-296585-yfh5d4io	121	9	-	-	:
cord-296585-yfh5d4io	121	10	The	the	DT
cord-296585-yfh5d4io	121	11	Innate	Innate	NNP
cord-296585-yfh5d4io	121	12	Immunity	Immunity	NNP
cord-296585-yfh5d4io	121	13	and	and	CC
cord-296585-yfh5d4io	121	14	Inflammasome	Inflammasome	NNP
cord-296585-yfh5d4io	121	15	Lung	Lung	NNP
cord-296585-yfh5d4io	121	16	structural	structural	JJ
cord-296585-yfh5d4io	121	17	cells	cell	NNS
cord-296585-yfh5d4io	121	18	(	(	-LRB-
cord-296585-yfh5d4io	121	19	epithelial	epithelial	JJ
cord-296585-yfh5d4io	121	20	and	and	CC
cord-296585-yfh5d4io	121	21	endothelial	endothelial	JJ
cord-296585-yfh5d4io	121	22	cells	cell	NNS
cord-296585-yfh5d4io	121	23	,	,	,
cord-296585-yfh5d4io	121	24	fibroblasts	fibroblast	NNS
cord-296585-yfh5d4io	121	25	,	,	,
cord-296585-yfh5d4io	121	26	and	and	CC
cord-296585-yfh5d4io	121	27	airway	airway	JJ
cord-296585-yfh5d4io	121	28	smooth	smooth	JJ
cord-296585-yfh5d4io	121	29	muscle	muscle	NN
cord-296585-yfh5d4io	121	30	cells	cell	NNS
cord-296585-yfh5d4io	121	31	)	)	-RRB-
cord-296585-yfh5d4io	121	32	are	be	VBP
cord-296585-yfh5d4io	121	33	activated	activate	VBN
cord-296585-yfh5d4io	121	34	by	by	IN
cord-296585-yfh5d4io	121	35	inhaled	inhale	VBN
cord-296585-yfh5d4io	121	36	irritants	irritant	NNS
cord-296585-yfh5d4io	121	37	through	through	IN
cord-296585-yfh5d4io	121	38	the	the	DT
cord-296585-yfh5d4io	121	39	stimulation	stimulation	NN
cord-296585-yfh5d4io	121	40	of	of	IN
cord-296585-yfh5d4io	121	41	several	several	JJ
cord-296585-yfh5d4io	121	42	pattern	pattern	NN
cord-296585-yfh5d4io	121	43	recognitions	recognition	NNS
cord-296585-yfh5d4io	121	44	receptors	receptor	NNS
cord-296585-yfh5d4io	121	45	(	(	-LRB-
cord-296585-yfh5d4io	121	46	PRRs	PRRs	NNP
cord-296585-yfh5d4io	121	47	)	)	-RRB-
cord-296585-yfh5d4io	121	48	,	,	,
cord-296585-yfh5d4io	121	49	with	with	IN
cord-296585-yfh5d4io	121	50	Toll	Toll	NNP
cord-296585-yfh5d4io	121	51	-	-	HYPH
cord-296585-yfh5d4io	121	52	like	like	JJ
cord-296585-yfh5d4io	121	53	receptor	receptor	NN
cord-296585-yfh5d4io	121	54	(	(	-LRB-
cord-296585-yfh5d4io	121	55	TLR)-4	tlr)-4	NN
cord-296585-yfh5d4io	121	56	being	be	VBG
cord-296585-yfh5d4io	121	57	reported	report	VBN
cord-296585-yfh5d4io	121	58	as	as	IN
cord-296585-yfh5d4io	121	59	the	the	DT
cord-296585-yfh5d4io	121	60	key	key	JJ
cord-296585-yfh5d4io	121	61	player	player	NN
cord-296585-yfh5d4io	121	62	in	in	IN
cord-296585-yfh5d4io	121	63	most	most	JJS
cord-296585-yfh5d4io	121	64	of	of	IN
cord-296585-yfh5d4io	121	65	the	the	DT
cord-296585-yfh5d4io	121	66	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	121	67	responses	response	NNS
cord-296585-yfh5d4io	121	68	(	(	-LRB-
cord-296585-yfh5d4io	121	69	82	82	CD
cord-296585-yfh5d4io	121	70	)	)	-RRB-
cord-296585-yfh5d4io	121	71	(	(	-LRB-
cord-296585-yfh5d4io	121	72	83	83	CD
cord-296585-yfh5d4io	121	73	)	)	-RRB-
cord-296585-yfh5d4io	121	74	(	(	-LRB-
cord-296585-yfh5d4io	121	75	84	84	CD
cord-296585-yfh5d4io	121	76	)	)	-RRB-
cord-296585-yfh5d4io	121	77	(	(	-LRB-
cord-296585-yfh5d4io	121	78	85	85	CD
cord-296585-yfh5d4io	121	79	)	)	-RRB-
cord-296585-yfh5d4io	121	80	.	.	.
cord-296585-yfh5d4io	122	1	This	this	DT
cord-296585-yfh5d4io	122	2	causes	cause	VBZ
cord-296585-yfh5d4io	122	3	an	an	DT
cord-296585-yfh5d4io	122	4	increased	increase	VBN
cord-296585-yfh5d4io	122	5	expression	expression	NN
cord-296585-yfh5d4io	122	6	and	and	CC
cord-296585-yfh5d4io	122	7	release	release	NN
cord-296585-yfh5d4io	122	8	of	of	IN
cord-296585-yfh5d4io	122	9	an	an	DT
cord-296585-yfh5d4io	122	10	array	array	NN
cord-296585-yfh5d4io	122	11	of	of	IN
cord-296585-yfh5d4io	122	12	pro	pro	JJ
cord-296585-yfh5d4io	122	13	-	-	JJ
cord-296585-yfh5d4io	122	14	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	122	15	mediators	mediator	NNS
cord-296585-yfh5d4io	122	16	and	and	CC
cord-296585-yfh5d4io	122	17	chemokines	chemokine	NNS
cord-296585-yfh5d4io	122	18	through	through	IN
cord-296585-yfh5d4io	122	19	the	the	DT
cord-296585-yfh5d4io	122	20	oxidative	oxidative	JJ
cord-296585-yfh5d4io	122	21	pathway	pathway	NN
cord-296585-yfh5d4io	122	22	by	by	IN
cord-296585-yfh5d4io	122	23	the	the	DT
cord-296585-yfh5d4io	122	24	activated	activate	VBN
cord-296585-yfh5d4io	122	25	bronchial	bronchial	JJ
cord-296585-yfh5d4io	122	26	epithelial	epithelial	JJ
cord-296585-yfh5d4io	122	27	cells	cell	NNS
cord-296585-yfh5d4io	122	28	and	and	CC
cord-296585-yfh5d4io	122	29	immune	immune	JJ
cord-296585-yfh5d4io	122	30	cells	cell	NNS
cord-296585-yfh5d4io	122	31	(	(	-LRB-
cord-296585-yfh5d4io	122	32	alveolar	alveolar	JJ
cord-296585-yfh5d4io	122	33	macrophages	macrophage	NNS
cord-296585-yfh5d4io	122	34	)	)	-RRB-
cord-296585-yfh5d4io	122	35	.	.	.
cord-296585-yfh5d4io	123	1	The	the	DT
cord-296585-yfh5d4io	123	2	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	123	3	mediators	mediator	NNS
cord-296585-yfh5d4io	123	4	[	[	-LRB-
cord-296585-yfh5d4io	123	5	(	(	-LRB-
cord-296585-yfh5d4io	123	6	interleukin	interleukin	FW
cord-296585-yfh5d4io	123	7	(	(	-LRB-
cord-296585-yfh5d4io	123	8	IL)-1β	IL)-1β	NNP
cord-296585-yfh5d4io	123	9	,	,	,
cord-296585-yfh5d4io	123	10	IL-6	IL-6	NNP
cord-296585-yfh5d4io	123	11	,	,	,
cord-296585-yfh5d4io	123	12	IL-8	IL-8	NNP
cord-296585-yfh5d4io	123	13	,	,	,
cord-296585-yfh5d4io	123	14	IL-33	IL-33	NNP
cord-296585-yfh5d4io	123	15	,	,	,
cord-296585-yfh5d4io	123	16	C	C	NNP
cord-296585-yfh5d4io	123	17	-	-	HYPH
cord-296585-yfh5d4io	123	18	X	x	NN
cord-296585-yfh5d4io	123	19	-	-	HYPH
cord-296585-yfh5d4io	123	20	C	c	NN
cord-296585-yfh5d4io	123	21	motif	motif	NN
cord-296585-yfh5d4io	123	22	chemokine	chemokine	NN
cord-296585-yfh5d4io	123	23	ligand	ligand	NN
cord-296585-yfh5d4io	123	24	(	(	-LRB-
cord-296585-yfh5d4io	123	25	CXCL	CXCL	NNP
cord-296585-yfh5d4io	123	26	)	)	-RRB-
cord-296585-yfh5d4io	123	27	10	10	CD
cord-296585-yfh5d4io	123	28	,	,	,
cord-296585-yfh5d4io	123	29	granulocyte	granulocyte	NN
cord-296585-yfh5d4io	123	30	-	-	HYPH
cord-296585-yfh5d4io	123	31	macrophage	macrophage	NN
cord-296585-yfh5d4io	123	32	colonystimulating	colonystimulating	NN
cord-296585-yfh5d4io	123	33	factor	factor	NN
cord-296585-yfh5d4io	123	34	(	(	-LRB-
cord-296585-yfh5d4io	123	35	GM	GM	NNP
cord-296585-yfh5d4io	123	36	-	-	HYPH
cord-296585-yfh5d4io	123	37	CSF	CSF	NNP
cord-296585-yfh5d4io	123	38	)	)	-RRB-
cord-296585-yfh5d4io	123	39	,	,	,
cord-296585-yfh5d4io	123	40	granulocyte	granulocyte	NN
cord-296585-yfh5d4io	123	41	-	-	HYPH
cord-296585-yfh5d4io	123	42	colony	colony	NN
cord-296585-yfh5d4io	123	43	stimulating	stimulating	NN
cord-296585-yfh5d4io	123	44	factor	factor	NN
cord-296585-yfh5d4io	123	45	(	(	-LRB-
cord-296585-yfh5d4io	123	46	G	G	NNP
cord-296585-yfh5d4io	123	47	-	-	HYPH
cord-296585-yfh5d4io	123	48	CSF	CSF	NNP
cord-296585-yfh5d4io	123	49	)	)	-RRB-
cord-296585-yfh5d4io	123	50	,	,	,
cord-296585-yfh5d4io	123	51	tumor	tumor	NN
cord-296585-yfh5d4io	123	52	necrosis	necrosis	NN
cord-296585-yfh5d4io	123	53	factor	factor	NN
cord-296585-yfh5d4io	123	54	(	(	-LRB-
cord-296585-yfh5d4io	123	55	TNF)-α	tnf)-α	NN
cord-296585-yfh5d4io	123	56	,	,	,
cord-296585-yfh5d4io	123	57	fibroblast	fibroblast	NN
cord-296585-yfh5d4io	123	58	growth	growth	NN
cord-296585-yfh5d4io	123	59	factor	factor	NN
cord-296585-yfh5d4io	123	60	1	1	CD
cord-296585-yfh5d4io	123	61	and	and	CC
cord-296585-yfh5d4io	123	62	2	2	CD
cord-296585-yfh5d4io	123	63	(	(	-LRB-
cord-296585-yfh5d4io	123	64	FGF1/2	FGF1/2	NNP
cord-296585-yfh5d4io	123	65	)	)	-RRB-
cord-296585-yfh5d4io	123	66	,	,	,
cord-296585-yfh5d4io	123	67	transforming	transform	VBG
cord-296585-yfh5d4io	123	68	growth	growth	NN
cord-296585-yfh5d4io	123	69	factor	factor	NN
cord-296585-yfh5d4io	123	70	(	(	-LRB-
cord-296585-yfh5d4io	123	71	TGF)-β1	TGF)-β1	NNP
cord-296585-yfh5d4io	123	72	,	,	,
cord-296585-yfh5d4io	123	73	C	C	NNP
cord-296585-yfh5d4io	123	74	-	-	HYPH
cord-296585-yfh5d4io	123	75	C	C	NNP
cord-296585-yfh5d4io	123	76	motif	motif	NN
cord-296585-yfh5d4io	123	77	chemokine	chemokine	NN
cord-296585-yfh5d4io	123	78	ligand	ligand	NN
cord-296585-yfh5d4io	123	79	(	(	-LRB-
cord-296585-yfh5d4io	123	80	CCL	CCL	NNP
cord-296585-yfh5d4io	123	81	)	)	-RRB-
cord-296585-yfh5d4io	123	82	2	2	CD
cord-296585-yfh5d4io	123	83	,	,	,
cord-296585-yfh5d4io	123	84	CCL20	ccl20	NN
cord-296585-yfh5d4io	123	85	,	,	,
cord-296585-yfh5d4io	123	86	and	and	CC
cord-296585-yfh5d4io	123	87	thymic	thymic	JJ
cord-296585-yfh5d4io	123	88	stromal	stromal	JJ
cord-296585-yfh5d4io	123	89	lymphopoietin	lymphopoietin	NN
cord-296585-yfh5d4io	123	90	(	(	-LRB-
cord-296585-yfh5d4io	123	91	TSLP	TSLP	NNP
cord-296585-yfh5d4io	123	92	)	)	-RRB-
cord-296585-yfh5d4io	123	93	]	]	-RRB-
cord-296585-yfh5d4io	123	94	act	act	VBP
cord-296585-yfh5d4io	123	95	on	on	IN
cord-296585-yfh5d4io	123	96	recruited	recruit	VBN
cord-296585-yfh5d4io	123	97	immune	immune	JJ
cord-296585-yfh5d4io	123	98	cells	cell	NNS
cord-296585-yfh5d4io	123	99	and	and	CC
cord-296585-yfh5d4io	123	100	resident	resident	NN
cord-296585-yfh5d4io	123	101	cells	cell	NNS
cord-296585-yfh5d4io	123	102	to	to	TO
cord-296585-yfh5d4io	123	103	initiate	initiate	VB
cord-296585-yfh5d4io	123	104	a	a	DT
cord-296585-yfh5d4io	123	105	series	series	NN
cord-296585-yfh5d4io	123	106	of	of	IN
cord-296585-yfh5d4io	123	107	innate	innate	JJ
cord-296585-yfh5d4io	123	108	immune	immune	JJ
cord-296585-yfh5d4io	123	109	responses	response	NNS
cord-296585-yfh5d4io	123	110	(	(	-LRB-
cord-296585-yfh5d4io	123	111	23	23	CD
cord-296585-yfh5d4io	123	112	,	,	,
cord-296585-yfh5d4io	123	113	(	(	-LRB-
cord-296585-yfh5d4io	123	114	86	86	CD
cord-296585-yfh5d4io	123	115	)	)	-RRB-
cord-296585-yfh5d4io	123	116	(	(	-LRB-
cord-296585-yfh5d4io	123	117	87	87	CD
cord-296585-yfh5d4io	123	118	)	)	-RRB-
cord-296585-yfh5d4io	123	119	(	(	-LRB-
cord-296585-yfh5d4io	123	120	88	88	CD
cord-296585-yfh5d4io	123	121	)	)	-RRB-
cord-296585-yfh5d4io	123	122	(	(	-LRB-
cord-296585-yfh5d4io	123	123	89	89	CD
cord-296585-yfh5d4io	123	124	)	)	-RRB-
cord-296585-yfh5d4io	123	125	(	(	-LRB-
cord-296585-yfh5d4io	123	126	90	90	CD
cord-296585-yfh5d4io	123	127	)	)	-RRB-
cord-296585-yfh5d4io	123	128	.	.	.
cord-296585-yfh5d4io	124	1	Meanwhile	meanwhile	RB
cord-296585-yfh5d4io	124	2	,	,	,
cord-296585-yfh5d4io	124	3	activated	activate	VBN
cord-296585-yfh5d4io	124	4	alveolar	alveolar	NN
cord-296585-yfh5d4io	124	5	macrophages	macrophage	NNS
cord-296585-yfh5d4io	124	6	,	,	,
cord-296585-yfh5d4io	124	7	which	which	WDT
cord-296585-yfh5d4io	124	8	are	be	VBP
cord-296585-yfh5d4io	124	9	usually	usually	RB
cord-296585-yfh5d4io	124	10	patrolling	patrol	VBG
cord-296585-yfh5d4io	124	11	the	the	DT
cord-296585-yfh5d4io	124	12	lung	lung	NN
cord-296585-yfh5d4io	124	13	parenchyma	parenchyma	NN
cord-296585-yfh5d4io	124	14	,	,	,
cord-296585-yfh5d4io	124	15	further	further	RB
cord-296585-yfh5d4io	124	16	release	release	VB
cord-296585-yfh5d4io	124	17	more	more	RBR
cord-296585-yfh5d4io	124	18	pro	pro	JJ
cord-296585-yfh5d4io	124	19	-	-	JJ
cord-296585-yfh5d4io	124	20	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	124	21	mediators	mediator	NNS
cord-296585-yfh5d4io	124	22	and	and	CC
cord-296585-yfh5d4io	124	23	chemokines	chemokine	NNS
cord-296585-yfh5d4io	124	24	[	[	-LRB-
cord-296585-yfh5d4io	124	25	IL-1β	IL-1β	NNP
cord-296585-yfh5d4io	124	26	,	,	,
cord-296585-yfh5d4io	124	27	IL-6	IL-6	NNP
cord-296585-yfh5d4io	124	28	,	,	,
cord-296585-yfh5d4io	124	29	IL-8	IL-8	NNP
cord-296585-yfh5d4io	124	30	,	,	,
cord-296585-yfh5d4io	124	31	IL-23	IL-23	NNP
cord-296585-yfh5d4io	124	32	,	,	,
cord-296585-yfh5d4io	124	33	TNF	TNF	NNP
cord-296585-yfh5d4io	124	34	-	-	HYPH
cord-296585-yfh5d4io	124	35	α	α	NNP
cord-296585-yfh5d4io	124	36	,	,	,
cord-296585-yfh5d4io	124	37	CCL1	CCL1	NNP
cord-296585-yfh5d4io	124	38	,	,	,
cord-296585-yfh5d4io	124	39	CXCL1	CXCL1	NNP
cord-296585-yfh5d4io	124	40	,	,	,
cord-296585-yfh5d4io	125	1	CXCL5	CXCL5	NNP
cord-296585-yfh5d4io	125	2	(	(	-LRB-
cord-296585-yfh5d4io	125	3	ENA-78	ENA-78	NNP
cord-296585-yfh5d4io	125	4	)	)	-RRB-
cord-296585-yfh5d4io	125	5	,	,	,
cord-296585-yfh5d4io	125	6	CXCL9	CXCL9	NNP
cord-296585-yfh5d4io	125	7	,	,	,
cord-296585-yfh5d4io	126	1	CXCL10	CXCL10	NNP
cord-296585-yfh5d4io	126	2	,	,	,
cord-296585-yfh5d4io	126	3	CXCL11	CXCL11	NNP
cord-296585-yfh5d4io	126	4	,	,	,
cord-296585-yfh5d4io	126	5	CCL2	CCL2	NNP
cord-296585-yfh5d4io	126	6	,	,	,
cord-296585-yfh5d4io	126	7	leukotriene	leukotriene	NN
cord-296585-yfh5d4io	126	8	B4	B4	NNP
cord-296585-yfh5d4io	126	9	(	(	-LRB-
cord-296585-yfh5d4io	126	10	LTB	LTB	NNP
cord-296585-yfh5d4io	126	11	4	4	CD
cord-296585-yfh5d4io	126	12	)	)	-RRB-
cord-296585-yfh5d4io	126	13	]	]	-RRB-
cord-296585-yfh5d4io	126	14	,	,	,
cord-296585-yfh5d4io	126	15	ROS	ROS	NNP
cord-296585-yfh5d4io	126	16	,	,	,
cord-296585-yfh5d4io	126	17	elastolytic	elastolytic	JJ
cord-296585-yfh5d4io	126	18	enzyme	enzyme	NN
cord-296585-yfh5d4io	126	19	[	[	-LRB-
cord-296585-yfh5d4io	126	20	matrix	matrix	NNP
cord-296585-yfh5d4io	126	21	metalloprotease	metalloprotease	NNP
cord-296585-yfh5d4io	126	22	protein	protein	NNP
cord-296585-yfh5d4io	126	23	(	(	-LRB-
cord-296585-yfh5d4io	126	24	MMP)-2,−9	MMP)-2,−9	NNP
cord-296585-yfh5d4io	126	25	,	,	,
cord-296585-yfh5d4io	126	26	and−12	and−12	CD
cord-296585-yfh5d4io	126	27	;	;	:
cord-296585-yfh5d4io	126	28	and	and	CC
cord-296585-yfh5d4io	126	29	cathepsin	cathepsin	NN
cord-296585-yfh5d4io	126	30	-	-	HYPH
cord-296585-yfh5d4io	126	31	K,-L	k,-l	JJ
cord-296585-yfh5d4io	126	32	,	,	,
cord-296585-yfh5d4io	126	33	and	and	CC
cord-296585-yfh5d4io	126	34	-S	-S	JJS
cord-296585-yfh5d4io	126	35	]	]	-RRB-
cord-296585-yfh5d4io	126	36	,	,	,
cord-296585-yfh5d4io	126	37	GM	GM	NNP
cord-296585-yfh5d4io	126	38	-	-	HYPH
cord-296585-yfh5d4io	126	39	CSF	CSF	NNP
cord-296585-yfh5d4io	126	40	,	,	,
cord-296585-yfh5d4io	126	41	and	and	CC
cord-296585-yfh5d4io	126	42	G	G	NNP
cord-296585-yfh5d4io	126	43	-	-	HYPH
cord-296585-yfh5d4io	126	44	CSF	CSF	NNP
cord-296585-yfh5d4io	126	45	(	(	-LRB-
cord-296585-yfh5d4io	126	46	23	23	CD
cord-296585-yfh5d4io	126	47	,	,	,
cord-296585-yfh5d4io	126	48	91	91	CD
cord-296585-yfh5d4io	126	49	,	,	,
cord-296585-yfh5d4io	126	50	92	92	CD
cord-296585-yfh5d4io	126	51	)	)	-RRB-
cord-296585-yfh5d4io	126	52	.	.	.
cord-296585-yfh5d4io	127	1	The	the	DT
cord-296585-yfh5d4io	127	2	enhanced	enhanced	JJ
cord-296585-yfh5d4io	127	3	levels	level	NNS
cord-296585-yfh5d4io	127	4	of	of	IN
cord-296585-yfh5d4io	127	5	CCL2	CCL2	NNP
cord-296585-yfh5d4io	127	6	and	and	CC
cord-296585-yfh5d4io	127	7	CXCL1	CXCL1	NNP
cord-296585-yfh5d4io	127	8	result	result	NN
cord-296585-yfh5d4io	127	9	in	in	IN
cord-296585-yfh5d4io	127	10	recruitement	recruitement	NN
cord-296585-yfh5d4io	127	11	of	of	IN
cord-296585-yfh5d4io	127	12	blood	blood	NN
cord-296585-yfh5d4io	127	13	monocytes	monocyte	NNS
cord-296585-yfh5d4io	127	14	expressing	express	VBG
cord-296585-yfh5d4io	127	15	CCR2	CCR2	NNP
cord-296585-yfh5d4io	127	16	and	and	CC
cord-296585-yfh5d4io	127	17	CXCR2	CXCR2	NNS
cord-296585-yfh5d4io	128	1	(	(	-LRB-
cord-296585-yfh5d4io	128	2	receptors	receptor	NNS
cord-296585-yfh5d4io	128	3	for	for	IN
cord-296585-yfh5d4io	128	4	CCL2	CCL2	NNP
cord-296585-yfh5d4io	128	5	and	and	CC
cord-296585-yfh5d4io	128	6	CXCL1	CXCL1	NNP
cord-296585-yfh5d4io	128	7	,	,	,
cord-296585-yfh5d4io	128	8	respectively	respectively	RB
cord-296585-yfh5d4io	128	9	)	)	-RRB-
cord-296585-yfh5d4io	128	10	,	,	,
cord-296585-yfh5d4io	128	11	to	to	IN
cord-296585-yfh5d4io	128	12	the	the	DT
cord-296585-yfh5d4io	128	13	lung	lung	NN
cord-296585-yfh5d4io	128	14	and	and	CC
cord-296585-yfh5d4io	128	15	differentiate	differentiate	VB
cord-296585-yfh5d4io	128	16	locally	locally	RB
cord-296585-yfh5d4io	128	17	into	into	IN
cord-296585-yfh5d4io	128	18	macrophages	macrophage	NNS
cord-296585-yfh5d4io	128	19	.	.	.
cord-296585-yfh5d4io	129	1	Interestingly	interestingly	RB
cord-296585-yfh5d4io	129	2	,	,	,
cord-296585-yfh5d4io	129	3	there	there	EX
cord-296585-yfh5d4io	129	4	are	be	VBP
cord-296585-yfh5d4io	129	5	higher	high	JJR
cord-296585-yfh5d4io	129	6	expression	expression	NN
cord-296585-yfh5d4io	129	7	levels	level	NNS
cord-296585-yfh5d4io	129	8	of	of	IN
cord-296585-yfh5d4io	129	9	the	the	DT
cord-296585-yfh5d4io	129	10	CCR2	CCR2	NNP
cord-296585-yfh5d4io	129	11	and	and	CC
cord-296585-yfh5d4io	129	12	CXCR2	CXCR2	NNS
cord-296585-yfh5d4io	129	13	found	find	VBD
cord-296585-yfh5d4io	129	14	on	on	IN
cord-296585-yfh5d4io	129	15	blood	blood	NN
cord-296585-yfh5d4io	129	16	monocytes	monocyte	NNS
cord-296585-yfh5d4io	129	17	in	in	IN
cord-296585-yfh5d4io	129	18	COPD	COPD	NNP
cord-296585-yfh5d4io	129	19	subjects	subject	NNS
cord-296585-yfh5d4io	129	20	(	(	-LRB-
cord-296585-yfh5d4io	129	21	93	93	CD
cord-296585-yfh5d4io	129	22	)	)	-RRB-
cord-296585-yfh5d4io	129	23	.	.	.
cord-296585-yfh5d4io	130	1	This	this	DT
cord-296585-yfh5d4io	130	2	may	may	MD
cord-296585-yfh5d4io	130	3	explain	explain	VB
cord-296585-yfh5d4io	130	4	the	the	DT
cord-296585-yfh5d4io	130	5	rapid	rapid	JJ
cord-296585-yfh5d4io	130	6	recruitment	recruitment	NN
cord-296585-yfh5d4io	130	7	and	and	CC
cord-296585-yfh5d4io	130	8	excessive	excessive	JJ
cord-296585-yfh5d4io	130	9	accumulation	accumulation	NN
cord-296585-yfh5d4io	130	10	of	of	IN
cord-296585-yfh5d4io	130	11	monocyte	monocyte	NNP
cord-296585-yfh5d4io	130	12	-	-	HYPH
cord-296585-yfh5d4io	130	13	derived	derive	VBN
cord-296585-yfh5d4io	130	14	interstitial	interstitial	JJ
cord-296585-yfh5d4io	130	15	macrophages	macrophage	NNS
cord-296585-yfh5d4io	130	16	in	in	IN
cord-296585-yfh5d4io	130	17	the	the	DT
cord-296585-yfh5d4io	130	18	lung	lung	NN
cord-296585-yfh5d4io	130	19	tissue	tissue	NN
cord-296585-yfh5d4io	130	20	of	of	IN
cord-296585-yfh5d4io	130	21	COPD	COPD	NNP
cord-296585-yfh5d4io	130	22	patients	patient	NNS
cord-296585-yfh5d4io	130	23	(	(	-LRB-
cord-296585-yfh5d4io	130	24	94	94	CD
cord-296585-yfh5d4io	130	25	,	,	,
cord-296585-yfh5d4io	130	26	95	95	CD
cord-296585-yfh5d4io	130	27	)	)	-RRB-
cord-296585-yfh5d4io	130	28	.	.	.
cord-296585-yfh5d4io	131	1	Upregulation	Upregulation	NNP
cord-296585-yfh5d4io	131	2	of	of	IN
cord-296585-yfh5d4io	131	3	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	131	4	chemoattractors	chemoattractor	NNS
cord-296585-yfh5d4io	131	5	(	(	-LRB-
cord-296585-yfh5d4io	131	6	LTB	LTB	NNP
cord-296585-yfh5d4io	131	7	4	4	CD
cord-296585-yfh5d4io	131	8	,	,	,
cord-296585-yfh5d4io	131	9	CXCL1	CXCL1	NNP
cord-296585-yfh5d4io	131	10	,	,	,
cord-296585-yfh5d4io	131	11	CXCL5	CXCL5	NNP
cord-296585-yfh5d4io	131	12	,	,	,
cord-296585-yfh5d4io	131	13	IL-8	IL-8	NNP
cord-296585-yfh5d4io	131	14	,	,	,
cord-296585-yfh5d4io	131	15	and	and	CC
cord-296585-yfh5d4io	131	16	TNF	TNF	NNP
cord-296585-yfh5d4io	131	17	-	-	HYPH
cord-296585-yfh5d4io	131	18	α	α	NNP
cord-296585-yfh5d4io	131	19	)	)	-RRB-
cord-296585-yfh5d4io	131	20	induces	induce	VBZ
cord-296585-yfh5d4io	131	21	a	a	DT
cord-296585-yfh5d4io	131	22	massive	massive	JJ
cord-296585-yfh5d4io	131	23	migration	migration	NN
cord-296585-yfh5d4io	131	24	of	of	IN
cord-296585-yfh5d4io	131	25	circulating	circulate	VBG
cord-296585-yfh5d4io	131	26	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	131	27	into	into	IN
cord-296585-yfh5d4io	131	28	the	the	DT
cord-296585-yfh5d4io	131	29	lung	lung	NN
cord-296585-yfh5d4io	131	30	parenchyma	parenchyma	NN
cord-296585-yfh5d4io	131	31	(	(	-LRB-
cord-296585-yfh5d4io	131	32	96	96	CD
cord-296585-yfh5d4io	131	33	)	)	-RRB-
cord-296585-yfh5d4io	131	34	.	.	.
cord-296585-yfh5d4io	132	1	The	the	DT
cord-296585-yfh5d4io	132	2	transmigration	transmigration	NN
cord-296585-yfh5d4io	132	3	of	of	IN
cord-296585-yfh5d4io	132	4	blood	blood	NN
cord-296585-yfh5d4io	132	5	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	132	6	occurs	occur	VBZ
cord-296585-yfh5d4io	132	7	through	through	IN
cord-296585-yfh5d4io	132	8	adherence	adherence	NN
cord-296585-yfh5d4io	132	9	of	of	IN
cord-296585-yfh5d4io	132	10	the	the	DT
cord-296585-yfh5d4io	132	11	granulocytes	granulocyte	NNS
cord-296585-yfh5d4io	132	12	to	to	IN
cord-296585-yfh5d4io	132	13	E	e	NN
cord-296585-yfh5d4io	132	14	-	-	NN
cord-296585-yfh5d4io	132	15	selectin	selectin	NN
cord-296585-yfh5d4io	132	16	of	of	IN
cord-296585-yfh5d4io	132	17	endothelial	endothelial	JJ
cord-296585-yfh5d4io	132	18	cells	cell	NNS
cord-296585-yfh5d4io	132	19	that	that	WDT
cord-296585-yfh5d4io	132	20	is	be	VBZ
cord-296585-yfh5d4io	132	21	found	find	VBN
cord-296585-yfh5d4io	132	22	to	to	TO
cord-296585-yfh5d4io	132	23	be	be	VB
cord-296585-yfh5d4io	132	24	upregulated	upregulate	VBN
cord-296585-yfh5d4io	132	25	in	in	IN
cord-296585-yfh5d4io	132	26	COPD	COPD	NNP
cord-296585-yfh5d4io	132	27	(	(	-LRB-
cord-296585-yfh5d4io	132	28	97	97	CD
cord-296585-yfh5d4io	132	29	)	)	-RRB-
cord-296585-yfh5d4io	132	30	.	.	.
cord-296585-yfh5d4io	133	1	This	this	DT
cord-296585-yfh5d4io	133	2	results	result	VBZ
cord-296585-yfh5d4io	133	3	in	in	IN
cord-296585-yfh5d4io	133	4	airway	airway	NN
cord-296585-yfh5d4io	133	5	neutrophilia	neutrophilia	NN
cord-296585-yfh5d4io	133	6	in	in	IN
cord-296585-yfh5d4io	133	7	several	several	JJ
cord-296585-yfh5d4io	133	8	COPD	COPD	NNP
cord-296585-yfh5d4io	133	9	patients	patient	NNS
cord-296585-yfh5d4io	133	10	(	(	-LRB-
cord-296585-yfh5d4io	133	11	96	96	CD
cord-296585-yfh5d4io	133	12	,	,	,
cord-296585-yfh5d4io	133	13	98	98	CD
cord-296585-yfh5d4io	133	14	,	,	,
cord-296585-yfh5d4io	133	15	99	99	CD
cord-296585-yfh5d4io	133	16	)	)	-RRB-
cord-296585-yfh5d4io	133	17	.	.	.
cord-296585-yfh5d4io	134	1	The	the	DT
cord-296585-yfh5d4io	134	2	recruited	recruit	VBN
cord-296585-yfh5d4io	134	3	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	134	4	(	(	-LRB-
cord-296585-yfh5d4io	134	5	to	to	IN
cord-296585-yfh5d4io	134	6	the	the	DT
cord-296585-yfh5d4io	134	7	lung	lung	NN
cord-296585-yfh5d4io	134	8	)	)	-RRB-
cord-296585-yfh5d4io	134	9	are	be	VBP
cord-296585-yfh5d4io	134	10	then	then	RB
cord-296585-yfh5d4io	134	11	activated	activate	VBN
cord-296585-yfh5d4io	134	12	to	to	IN
cord-296585-yfh5d4io	134	13	secrete	secrete	JJ
cord-296585-yfh5d4io	134	14	granule	granule	NN
cord-296585-yfh5d4io	134	15	proteins	protein	NNS
cord-296585-yfh5d4io	134	16	[	[	-LRB-
cord-296585-yfh5d4io	134	17	myeloperoxidase	myeloperoxidase	NNP
cord-296585-yfh5d4io	134	18	(	(	-LRB-
cord-296585-yfh5d4io	134	19	MPO	MPO	NNP
cord-296585-yfh5d4io	134	20	)	)	-RRB-
cord-296585-yfh5d4io	134	21	and	and	CC
cord-296585-yfh5d4io	135	1	neutrophil	neutrophil	NNP
cord-296585-yfh5d4io	135	2	lipocalin	lipocalin	NNP
cord-296585-yfh5d4io	135	3	]	]	-RRB-
cord-296585-yfh5d4io	135	4	while	while	IN
cord-296585-yfh5d4io	135	5	releasing	release	VBG
cord-296585-yfh5d4io	135	6	its	-PRON-	PRP$
cord-296585-yfh5d4io	135	7	own	own	JJ
cord-296585-yfh5d4io	135	8	IL-8	il-8	NN
cord-296585-yfh5d4io	135	9	for	for	IN
cord-296585-yfh5d4io	135	10	further	further	JJ
cord-296585-yfh5d4io	135	11	neutrophilic	neutrophilic	NNP
cord-296585-yfh5d4io	135	12	recruitment	recruitment	NN
cord-296585-yfh5d4io	135	13	and	and	CC
cord-296585-yfh5d4io	135	14	amplification	amplification	NN
cord-296585-yfh5d4io	135	15	of	of	IN
cord-296585-yfh5d4io	135	16	the	the	DT
cord-296585-yfh5d4io	135	17	inflammation	inflammation	NN
cord-296585-yfh5d4io	135	18	(	(	-LRB-
cord-296585-yfh5d4io	135	19	100	100	CD
cord-296585-yfh5d4io	135	20	)	)	-RRB-
cord-296585-yfh5d4io	135	21	.	.	.
cord-296585-yfh5d4io	136	1	In	in	IN
cord-296585-yfh5d4io	136	2	addition	addition	NN
cord-296585-yfh5d4io	136	3	to	to	IN
cord-296585-yfh5d4io	136	4	the	the	DT
cord-296585-yfh5d4io	136	5	macrophage	macrophage	NN
cord-296585-yfh5d4io	136	6	-	-	HYPH
cord-296585-yfh5d4io	136	7	derived	derive	VBN
cord-296585-yfh5d4io	136	8	proteases	protease	NNS
cord-296585-yfh5d4io	136	9	,	,	,
cord-296585-yfh5d4io	136	10	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	136	11	also	also	RB
cord-296585-yfh5d4io	136	12	secrete	secrete	VBP
cord-296585-yfh5d4io	136	13	serine	serine	NN
cord-296585-yfh5d4io	136	14	proteases	protease	NNS
cord-296585-yfh5d4io	136	15	[	[	-LRB-
cord-296585-yfh5d4io	136	16	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	136	17	elastase	elastase	NN
cord-296585-yfh5d4io	136	18	(	(	-LRB-
cord-296585-yfh5d4io	136	19	NE	NE	NNP
cord-296585-yfh5d4io	136	20	)	)	-RRB-
cord-296585-yfh5d4io	136	21	,	,	,
cord-296585-yfh5d4io	136	22	cathepsin	cathepsin	NN
cord-296585-yfh5d4io	136	23	G	g	NN
cord-296585-yfh5d4io	136	24	,	,	,
cord-296585-yfh5d4io	136	25	proteinase-3	proteinase-3	NNP
cord-296585-yfh5d4io	136	26	,	,	,
cord-296585-yfh5d4io	136	27	MMP-8	MMP-8	NNP
cord-296585-yfh5d4io	136	28	,	,	,
cord-296585-yfh5d4io	136	29	and	and	CC
cord-296585-yfh5d4io	136	30	MMP-9	MMP-9	NNP
cord-296585-yfh5d4io	136	31	]	]	-RRB-
cord-296585-yfh5d4io	136	32	that	that	WDT
cord-296585-yfh5d4io	136	33	are	be	VBP
cord-296585-yfh5d4io	136	34	associated	associate	VBN
cord-296585-yfh5d4io	136	35	with	with	IN
cord-296585-yfh5d4io	136	36	serious	serious	JJ
cord-296585-yfh5d4io	136	37	alveolar	alveolar	JJ
cord-296585-yfh5d4io	136	38	destruction	destruction	NN
cord-296585-yfh5d4io	136	39	in	in	IN
cord-296585-yfh5d4io	136	40	emphysema	emphysema	NN
cord-296585-yfh5d4io	136	41	(	(	-LRB-
cord-296585-yfh5d4io	136	42	101	101	CD
cord-296585-yfh5d4io	136	43	)	)	-RRB-
cord-296585-yfh5d4io	136	44	.	.	.
cord-296585-yfh5d4io	137	1	The	the	DT
cord-296585-yfh5d4io	137	2	protease	protease	NN
cord-296585-yfh5d4io	137	3	activity	activity	NN
cord-296585-yfh5d4io	137	4	may	may	MD
cord-296585-yfh5d4io	137	5	be	be	VB
cord-296585-yfh5d4io	137	6	further	further	RB
cord-296585-yfh5d4io	137	7	enhanced	enhance	VBN
cord-296585-yfh5d4io	137	8	in	in	IN
cord-296585-yfh5d4io	137	9	conditions	condition	NNS
cord-296585-yfh5d4io	137	10	with	with	IN
cord-296585-yfh5d4io	137	11	genetic	genetic	JJ
cord-296585-yfh5d4io	137	12	deficiencies	deficiency	NNS
cord-296585-yfh5d4io	137	13	or	or	CC
cord-296585-yfh5d4io	137	14	suppressed	suppress	VBN
cord-296585-yfh5d4io	137	15	expression	expression	NN
cord-296585-yfh5d4io	137	16	of	of	IN
cord-296585-yfh5d4io	137	17	α1-antitrypsin	α1-antitrypsin	NNS
cord-296585-yfh5d4io	137	18	by	by	IN
cord-296585-yfh5d4io	137	19	tobacco	tobacco	NN
cord-296585-yfh5d4io	137	20	smoke	smoke	NN
cord-296585-yfh5d4io	137	21	.	.	.
cord-296585-yfh5d4io	138	1	In	in	IN
cord-296585-yfh5d4io	138	2	addition	addition	NN
cord-296585-yfh5d4io	138	3	,	,	,
cord-296585-yfh5d4io	138	4	NE	NE	NNP
cord-296585-yfh5d4io	138	5	,	,	,
cord-296585-yfh5d4io	138	6	cathepsin	cathepsin	NN
cord-296585-yfh5d4io	138	7	G	g	NN
cord-296585-yfh5d4io	138	8	,	,	,
cord-296585-yfh5d4io	138	9	and	and	CC
cord-296585-yfh5d4io	138	10	proteinase-3	proteinase-3	NNP
cord-296585-yfh5d4io	138	11	are	be	VBP
cord-296585-yfh5d4io	138	12	involved	involve	VBN
cord-296585-yfh5d4io	138	13	in	in	IN
cord-296585-yfh5d4io	138	14	the	the	DT
cord-296585-yfh5d4io	138	15	stimulation	stimulation	NN
cord-296585-yfh5d4io	138	16	of	of	IN
cord-296585-yfh5d4io	138	17	mucus	mucus	NN
cord-296585-yfh5d4io	138	18	secretion	secretion	NN
cord-296585-yfh5d4io	138	19	from	from	IN
cord-296585-yfh5d4io	138	20	submucosal	submucosal	NN
cord-296585-yfh5d4io	138	21	glands	gland	NNS
cord-296585-yfh5d4io	138	22	and	and	CC
cord-296585-yfh5d4io	138	23	goblet	goblet	NN
cord-296585-yfh5d4io	138	24	cells	cell	NNS
cord-296585-yfh5d4io	138	25	,	,	,
cord-296585-yfh5d4io	138	26	resulting	result	VBG
cord-296585-yfh5d4io	138	27	in	in	IN
cord-296585-yfh5d4io	138	28	airway	airway	NN
cord-296585-yfh5d4io	138	29	mucus	mucus	NN
cord-296585-yfh5d4io	138	30	hypersecretion	hypersecretion	NN
cord-296585-yfh5d4io	138	31	and	and	CC
cord-296585-yfh5d4io	138	32	airway	airway	NN
cord-296585-yfh5d4io	138	33	obstruction	obstruction	NN
cord-296585-yfh5d4io	138	34	in	in	IN
cord-296585-yfh5d4io	138	35	COPD	COPD	NNP
cord-296585-yfh5d4io	138	36	(	(	-LRB-
cord-296585-yfh5d4io	138	37	101	101	CD
cord-296585-yfh5d4io	138	38	)	)	-RRB-
cord-296585-yfh5d4io	138	39	.	.	.
cord-296585-yfh5d4io	139	1	The	the	DT
cord-296585-yfh5d4io	139	2	NLRP3	nlrp3	NN
cord-296585-yfh5d4io	139	3	(	(	-LRB-
cord-296585-yfh5d4io	139	4	NLRP3	nlrp3	NN
cord-296585-yfh5d4io	139	5	:	:	:
cord-296585-yfh5d4io	139	6	nucleotide	nucleotide	NN
cord-296585-yfh5d4io	139	7	-	-	HYPH
cord-296585-yfh5d4io	139	8	binding	bind	VBG
cord-296585-yfh5d4io	139	9	domain	domain	NN
cord-296585-yfh5d4io	139	10	,	,	,
cord-296585-yfh5d4io	139	11	leucinerich	leucinerich	NNP
cord-296585-yfh5d4io	139	12	-	-	HYPH
cord-296585-yfh5d4io	139	13	containing	contain	VBG
cord-296585-yfh5d4io	139	14	family	family	NN
cord-296585-yfh5d4io	139	15	,	,	,
cord-296585-yfh5d4io	139	16	pyrin	pyrin	NN
cord-296585-yfh5d4io	139	17	domain	domain	NN
cord-296585-yfh5d4io	139	18	-	-	:
cord-296585-yfh5d4io	139	19	containing-3	containing-3	NNP
cord-296585-yfh5d4io	139	20	OR	or	CC
cord-296585-yfh5d4io	139	21	Nod	nod	JJ
cord-296585-yfh5d4io	139	22	-	-	HYPH
cord-296585-yfh5d4io	139	23	like	like	JJ
cord-296585-yfh5d4io	139	24	receptor	receptor	NN
cord-296585-yfh5d4io	139	25	protein	protein	NN
cord-296585-yfh5d4io	139	26	3	3	CD
cord-296585-yfh5d4io	139	27	)	)	-RRB-
cord-296585-yfh5d4io	140	1	inflammasome	inflammasome	NNP
cord-296585-yfh5d4io	140	2	is	be	VBZ
cord-296585-yfh5d4io	140	3	a	a	DT
cord-296585-yfh5d4io	140	4	cytosolic	cytosolic	JJ
cord-296585-yfh5d4io	140	5	multi	multi	JJ
cord-296585-yfh5d4io	140	6	-	-	JJ
cord-296585-yfh5d4io	140	7	protein	protein	JJ
cord-296585-yfh5d4io	140	8	complex	complex	NN
cord-296585-yfh5d4io	140	9	(	(	-LRB-
cord-296585-yfh5d4io	140	10	consisting	consist	VBG
cord-296585-yfh5d4io	140	11	of	of	IN
cord-296585-yfh5d4io	140	12	the	the	DT
cord-296585-yfh5d4io	140	13	inflammation	inflammation	NN
cord-296585-yfh5d4io	140	14	sensor	sensor	NN
cord-296585-yfh5d4io	140	15	protein	protein	NN
cord-296585-yfh5d4io	140	16	NLRP3	nlrp3	NN
cord-296585-yfh5d4io	140	17	,	,	,
cord-296585-yfh5d4io	140	18	adapter	adapter	NN
cord-296585-yfh5d4io	140	19	protein	protein	NN
cord-296585-yfh5d4io	140	20	ASC	ASC	NNP
cord-296585-yfh5d4io	140	21	,	,	,
cord-296585-yfh5d4io	140	22	and	and	CC
cord-296585-yfh5d4io	140	23	the	the	DT
cord-296585-yfh5d4io	140	24	effector	effector	NN
cord-296585-yfh5d4io	140	25	protein	protein	NN
cord-296585-yfh5d4io	140	26	caspase-1	caspase-1	NNP
cord-296585-yfh5d4io	140	27	)	)	-RRB-
cord-296585-yfh5d4io	140	28	(	(	-LRB-
cord-296585-yfh5d4io	140	29	102	102	CD
cord-296585-yfh5d4io	140	30	)	)	-RRB-
cord-296585-yfh5d4io	140	31	.	.	.
cord-296585-yfh5d4io	141	1	The	the	DT
cord-296585-yfh5d4io	141	2	NLRP3	nlrp3	NN
cord-296585-yfh5d4io	141	3	inflammasomes	inflammasome	NNS
cord-296585-yfh5d4io	141	4	are	be	VBP
cord-296585-yfh5d4io	141	5	involved	involve	VBN
cord-296585-yfh5d4io	141	6	in	in	IN
cord-296585-yfh5d4io	141	7	the	the	DT
cord-296585-yfh5d4io	141	8	COPD	COPD	NNP
cord-296585-yfh5d4io	141	9	airway	airway	NN
cord-296585-yfh5d4io	141	10	inflammation	inflammation	NN
cord-296585-yfh5d4io	141	11	by	by	IN
cord-296585-yfh5d4io	141	12	regulating	regulate	VBG
cord-296585-yfh5d4io	141	13	the	the	DT
cord-296585-yfh5d4io	141	14	production	production	NN
cord-296585-yfh5d4io	141	15	of	of	IN
cord-296585-yfh5d4io	141	16	pro	pro	JJ
cord-296585-yfh5d4io	141	17	-	-	JJ
cord-296585-yfh5d4io	141	18	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	141	19	cytokines	cytokine	NNS
cord-296585-yfh5d4io	141	20	IL-1α	il-1α	NN
cord-296585-yfh5d4io	141	21	,	,	,
cord-296585-yfh5d4io	141	22	IL-1β	IL-1β	NNP
cord-296585-yfh5d4io	141	23	,	,	,
cord-296585-yfh5d4io	141	24	and	and	CC
cord-296585-yfh5d4io	141	25	IL-18	IL-18	NNP
cord-296585-yfh5d4io	141	26	.	.	.
cord-296585-yfh5d4io	142	1	These	these	DT
cord-296585-yfh5d4io	142	2	cytokines	cytokine	NNS
cord-296585-yfh5d4io	142	3	are	be	VBP
cord-296585-yfh5d4io	142	4	important	important	JJ
cord-296585-yfh5d4io	142	5	for	for	IN
cord-296585-yfh5d4io	142	6	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	142	7	survival	survival	NN
cord-296585-yfh5d4io	142	8	and	and	CC
cord-296585-yfh5d4io	142	9	activation	activation	NN
cord-296585-yfh5d4io	142	10	of	of	IN
cord-296585-yfh5d4io	142	11	T	T	NNP
cord-296585-yfh5d4io	142	12	helper	helper	NN
cord-296585-yfh5d4io	142	13	(	(	-LRB-
cord-296585-yfh5d4io	142	14	Th	Th	NNP
cord-296585-yfh5d4io	142	15	)	)	-RRB-
cord-296585-yfh5d4io	142	16	17	17	CD
cord-296585-yfh5d4io	142	17	cells	cell	NNS
cord-296585-yfh5d4io	142	18	(	(	-LRB-
cord-296585-yfh5d4io	142	19	103	103	CD
cord-296585-yfh5d4io	142	20	)	)	-RRB-
cord-296585-yfh5d4io	142	21	.	.	.
cord-296585-yfh5d4io	143	1	Interestingly	interestingly	RB
cord-296585-yfh5d4io	143	2	,	,	,
cord-296585-yfh5d4io	143	3	local	local	JJ
cord-296585-yfh5d4io	143	4	airway	airway	NN
cord-296585-yfh5d4io	143	5	NLRP3	nlrp3	NN
cord-296585-yfh5d4io	143	6	inflammasome	inflammasome	NNP
cord-296585-yfh5d4io	143	7	activation	activation	NN
cord-296585-yfh5d4io	143	8	is	be	VBZ
cord-296585-yfh5d4io	143	9	positively	positively	RB
cord-296585-yfh5d4io	143	10	correlated	correlate	VBN
cord-296585-yfh5d4io	143	11	with	with	IN
cord-296585-yfh5d4io	143	12	acute	acute	JJ
cord-296585-yfh5d4io	143	13	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	143	14	and	and	CC
cord-296585-yfh5d4io	143	15	lower	low	JJR
cord-296585-yfh5d4io	143	16	airway	airway	NN
cord-296585-yfh5d4io	143	17	microbial	microbial	JJ
cord-296585-yfh5d4io	143	18	colonization	colonization	NN
cord-296585-yfh5d4io	143	19	in	in	IN
cord-296585-yfh5d4io	143	20	COPD	COPD	NNP
cord-296585-yfh5d4io	143	21	patients	patient	NNS
cord-296585-yfh5d4io	143	22	(	(	-LRB-
cord-296585-yfh5d4io	143	23	103	103	CD
cord-296585-yfh5d4io	143	24	,	,	,
cord-296585-yfh5d4io	143	25	104	104	CD
cord-296585-yfh5d4io	143	26	)	)	-RRB-
cord-296585-yfh5d4io	143	27	.	.	.
cord-296585-yfh5d4io	144	1	Moreover	moreover	RB
cord-296585-yfh5d4io	144	2	,	,	,
cord-296585-yfh5d4io	144	3	in	in	IN
cord-296585-yfh5d4io	144	4	an	an	DT
cord-296585-yfh5d4io	144	5	elastase	elastase	NN
cord-296585-yfh5d4io	144	6	-	-	HYPH
cord-296585-yfh5d4io	144	7	induced	induce	VBN
cord-296585-yfh5d4io	144	8	emphysema	emphysema	NN
cord-296585-yfh5d4io	144	9	model	model	NN
cord-296585-yfh5d4io	144	10	,	,	,
cord-296585-yfh5d4io	144	11	the	the	DT
cord-296585-yfh5d4io	144	12	NLRP3	NLRP3	NNP
cord-296585-yfh5d4io	144	13	inflammasome	inflammasome	NNP
cord-296585-yfh5d4io	144	14	is	be	VBZ
cord-296585-yfh5d4io	144	15	activated	activate	VBN
cord-296585-yfh5d4io	144	16	in	in	IN
cord-296585-yfh5d4io	144	17	addition	addition	NN
cord-296585-yfh5d4io	144	18	to	to	IN
cord-296585-yfh5d4io	144	19	hyperproduction	hyperproduction	NN
cord-296585-yfh5d4io	144	20	of	of	IN
cord-296585-yfh5d4io	144	21	mucin	mucin	NN
cord-296585-yfh5d4io	144	22	MUC5AC	MUC5AC	NNP
cord-296585-yfh5d4io	144	23	by	by	IN
cord-296585-yfh5d4io	144	24	diesel	diesel	NN
cord-296585-yfh5d4io	144	25	extract	extract	NN
cord-296585-yfh5d4io	144	26	particles	particle	NNS
cord-296585-yfh5d4io	144	27	,	,	,
cord-296585-yfh5d4io	144	28	extracellular	extracellular	JJ
cord-296585-yfh5d4io	144	29	ATP	ATP	NNP
cord-296585-yfh5d4io	144	30	,	,	,
cord-296585-yfh5d4io	144	31	and	and	CC
cord-296585-yfh5d4io	144	32	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	144	33	protein	protein	NN
cord-296585-yfh5d4io	144	34	S100	S100	NNP
cord-296585-yfh5d4io	144	35	(	(	-LRB-
cord-296585-yfh5d4io	144	36	105	105	CD
cord-296585-yfh5d4io	144	37	,	,	,
cord-296585-yfh5d4io	144	38	106	106	CD
cord-296585-yfh5d4io	144	39	)	)	-RRB-
cord-296585-yfh5d4io	144	40	.	.	.
cord-296585-yfh5d4io	145	1	The	the	DT
cord-296585-yfh5d4io	145	2	adaptive	adaptive	JJ
cord-296585-yfh5d4io	145	3	immunity	immunity	NN
cord-296585-yfh5d4io	145	4	is	be	VBZ
cord-296585-yfh5d4io	145	5	initiated	initiate	VBN
cord-296585-yfh5d4io	145	6	at	at	IN
cord-296585-yfh5d4io	145	7	a	a	DT
cord-296585-yfh5d4io	145	8	later	later	JJ
cord-296585-yfh5d4io	145	9	stage	stage	NN
cord-296585-yfh5d4io	145	10	,	,	,
cord-296585-yfh5d4io	145	11	and	and	CC
cord-296585-yfh5d4io	145	12	is	be	VBZ
cord-296585-yfh5d4io	145	13	recognized	recognize	VBN
cord-296585-yfh5d4io	145	14	by	by	IN
cord-296585-yfh5d4io	145	15	the	the	DT
cord-296585-yfh5d4io	145	16	increased	increase	VBN
cord-296585-yfh5d4io	145	17	number	number	NN
cord-296585-yfh5d4io	145	18	of	of	IN
cord-296585-yfh5d4io	145	19	T	t	NN
cord-296585-yfh5d4io	145	20	and	and	CC
cord-296585-yfh5d4io	145	21	B	b	NN
cord-296585-yfh5d4io	145	22	lymphocytes	lymphocyte	NNS
cord-296585-yfh5d4io	145	23	and	and	CC
cord-296585-yfh5d4io	145	24	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	145	25	dendritic	dendritic	JJ
cord-296585-yfh5d4io	145	26	cells	cell	NNS
cord-296585-yfh5d4io	145	27	.	.	.
cord-296585-yfh5d4io	146	1	Dendritic	dendritic	JJ
cord-296585-yfh5d4io	146	2	cells	cell	NNS
cord-296585-yfh5d4io	146	3	are	be	VBP
cord-296585-yfh5d4io	146	4	the	the	DT
cord-296585-yfh5d4io	146	5	major	major	JJ
cord-296585-yfh5d4io	146	6	antigen	antigen	NN
cord-296585-yfh5d4io	146	7	-	-	HYPH
cord-296585-yfh5d4io	146	8	presenting	present	VBG
cord-296585-yfh5d4io	146	9	cells	cell	NNS
cord-296585-yfh5d4io	146	10	(	(	-LRB-
cord-296585-yfh5d4io	146	11	APC	APC	NNP
cord-296585-yfh5d4io	146	12	)	)	-RRB-
cord-296585-yfh5d4io	146	13	in	in	IN
cord-296585-yfh5d4io	146	14	the	the	DT
cord-296585-yfh5d4io	146	15	airways	airway	NNS
cord-296585-yfh5d4io	146	16	,	,	,
cord-296585-yfh5d4io	146	17	and	and	CC
cord-296585-yfh5d4io	146	18	link	link	VB
cord-296585-yfh5d4io	146	19	the	the	DT
cord-296585-yfh5d4io	146	20	innate	innate	JJ
cord-296585-yfh5d4io	146	21	and	and	CC
cord-296585-yfh5d4io	146	22	adaptive	adaptive	JJ
cord-296585-yfh5d4io	146	23	immunity	immunity	NN
cord-296585-yfh5d4io	146	24	.	.	.
cord-296585-yfh5d4io	147	1	Circulating	circulate	VBG
cord-296585-yfh5d4io	147	2	dendritic	dendritic	JJ
cord-296585-yfh5d4io	147	3	cells	cell	NNS
cord-296585-yfh5d4io	147	4	(	(	-LRB-
cord-296585-yfh5d4io	147	5	expressing	express	VBG
cord-296585-yfh5d4io	147	6	receptors	receptor	NNS
cord-296585-yfh5d4io	147	7	CCR2	CCR2	NNP
cord-296585-yfh5d4io	147	8	and	and	CC
cord-296585-yfh5d4io	147	9	CCR6	CCR6	NNP
cord-296585-yfh5d4io	147	10	)	)	-RRB-
cord-296585-yfh5d4io	147	11	are	be	VBP
cord-296585-yfh5d4io	147	12	recruited	recruit	VBN
cord-296585-yfh5d4io	147	13	to	to	IN
cord-296585-yfh5d4io	147	14	the	the	DT
cord-296585-yfh5d4io	147	15	airway	airway	NN
cord-296585-yfh5d4io	147	16	via	via	IN
cord-296585-yfh5d4io	147	17	dendritic	dendritic	JJ
cord-296585-yfh5d4io	147	18	chemoattractants	chemoattractants	NNP
cord-296585-yfh5d4io	147	19	CCL2	CCL2	NNP
cord-296585-yfh5d4io	147	20	and	and	CC
cord-296585-yfh5d4io	147	21	CCL20	CCL20	NNP
cord-296585-yfh5d4io	147	22	released	release	VBN
cord-296585-yfh5d4io	147	23	by	by	IN
cord-296585-yfh5d4io	147	24	activated	activate	VBN
cord-296585-yfh5d4io	147	25	airway	airway	NN
cord-296585-yfh5d4io	147	26	epithelial	epithelial	JJ
cord-296585-yfh5d4io	147	27	cells	cell	NNS
cord-296585-yfh5d4io	147	28	in	in	IN
cord-296585-yfh5d4io	147	29	response	response	NN
cord-296585-yfh5d4io	147	30	to	to	IN
cord-296585-yfh5d4io	147	31	cigarette	cigarette	NN
cord-296585-yfh5d4io	147	32	smoke	smoke	NN
cord-296585-yfh5d4io	147	33	(	(	-LRB-
cord-296585-yfh5d4io	147	34	107	107	CD
cord-296585-yfh5d4io	147	35	,	,	,
cord-296585-yfh5d4io	147	36	108	108	CD
cord-296585-yfh5d4io	147	37	)	)	-RRB-
cord-296585-yfh5d4io	147	38	.	.	.
cord-296585-yfh5d4io	148	1	Dendritic	dendritic	JJ
cord-296585-yfh5d4io	148	2	cells	cell	NNS
cord-296585-yfh5d4io	148	3	act	act	VBP
cord-296585-yfh5d4io	148	4	by	by	IN
cord-296585-yfh5d4io	148	5	endocytosis	endocytosis	NN
cord-296585-yfh5d4io	148	6	of	of	IN
cord-296585-yfh5d4io	148	7	inhaled	inhale	VBN
cord-296585-yfh5d4io	148	8	irritants	irritant	NNS
cord-296585-yfh5d4io	148	9	that	that	WDT
cord-296585-yfh5d4io	148	10	subsequently	subsequently	RB
cord-296585-yfh5d4io	148	11	are	be	VBP
cord-296585-yfh5d4io	148	12	processed	process	VBN
cord-296585-yfh5d4io	148	13	into	into	IN
cord-296585-yfh5d4io	148	14	antigen	antigen	NN
cord-296585-yfh5d4io	148	15	peptides	peptide	NNS
cord-296585-yfh5d4io	148	16	during	during	IN
cord-296585-yfh5d4io	148	17	maturation	maturation	NN
cord-296585-yfh5d4io	148	18	and	and	CC
cord-296585-yfh5d4io	148	19	further	further	JJ
cord-296585-yfh5d4io	148	20	migration	migration	NN
cord-296585-yfh5d4io	148	21	to	to	IN
cord-296585-yfh5d4io	148	22	lymph	lymph	NN
cord-296585-yfh5d4io	148	23	nodes	node	NNS
cord-296585-yfh5d4io	148	24	.	.	.
cord-296585-yfh5d4io	149	1	Uncommitted	uncommitted	JJ
cord-296585-yfh5d4io	149	2	T	t	NN
cord-296585-yfh5d4io	149	3	lymphocytes	lymphocyte	NNS
cord-296585-yfh5d4io	149	4	are	be	VBP
cord-296585-yfh5d4io	149	5	thereafter	thereafter	RB
cord-296585-yfh5d4io	149	6	primed	prime	VBN
cord-296585-yfh5d4io	149	7	by	by	IN
cord-296585-yfh5d4io	149	8	the	the	DT
cord-296585-yfh5d4io	149	9	presented	present	VBN
cord-296585-yfh5d4io	149	10	antigen	antigen	NN
cord-296585-yfh5d4io	149	11	.	.	.
cord-296585-yfh5d4io	150	1	These	these	DT
cord-296585-yfh5d4io	150	2	important	important	JJ
cord-296585-yfh5d4io	150	3	cells	cell	NNS
cord-296585-yfh5d4io	150	4	are	be	VBP
cord-296585-yfh5d4io	150	5	activated	activate	VBN
cord-296585-yfh5d4io	150	6	by	by	IN
cord-296585-yfh5d4io	150	7	IL-12	IL-12	NNP
cord-296585-yfh5d4io	150	8	released	release	VBN
cord-296585-yfh5d4io	150	9	from	from	IN
cord-296585-yfh5d4io	150	10	dendritic	dendritic	JJ
cord-296585-yfh5d4io	150	11	cells	cell	NNS
cord-296585-yfh5d4io	150	12	for	for	IN
cord-296585-yfh5d4io	150	13	subsequent	subsequent	JJ
cord-296585-yfh5d4io	150	14	commitment	commitment	NN
cord-296585-yfh5d4io	150	15	into	into	IN
cord-296585-yfh5d4io	150	16	antigen	antigen	NN
cord-296585-yfh5d4io	150	17	-	-	HYPH
cord-296585-yfh5d4io	150	18	specific	specific	JJ
cord-296585-yfh5d4io	150	19	T	t	NN
cord-296585-yfh5d4io	150	20	cell	cell	NN
cord-296585-yfh5d4io	150	21	lineages	lineage	NNS
cord-296585-yfh5d4io	150	22	,	,	,
cord-296585-yfh5d4io	150	23	i.e.	i.e.	FW
cord-296585-yfh5d4io	150	24	,	,	,
cord-296585-yfh5d4io	150	25	T	T	NNP
cord-296585-yfh5d4io	150	26	helper	helper	NN
cord-296585-yfh5d4io	150	27	1	1	CD
cord-296585-yfh5d4io	150	28	(	(	-LRB-
cord-296585-yfh5d4io	150	29	Th1	Th1	NNP
cord-296585-yfh5d4io	150	30	;	;	:
cord-296585-yfh5d4io	150	31	CD3	CD3	NNP
cord-296585-yfh5d4io	150	32	+	+	SYM
cord-296585-yfh5d4io	150	33	CD4	CD4	NNP
cord-296585-yfh5d4io	150	34	+	+	CC
cord-296585-yfh5d4io	150	35	)	)	-RRB-
cord-296585-yfh5d4io	150	36	cells	cell	NNS
cord-296585-yfh5d4io	150	37	,	,	,
cord-296585-yfh5d4io	150	38	whereas	whereas	IN
cord-296585-yfh5d4io	150	39	immature	immature	JJ
cord-296585-yfh5d4io	150	40	dendritic	dendritic	JJ
cord-296585-yfh5d4io	150	41	cells	cell	NNS
cord-296585-yfh5d4io	150	42	in	in	IN
cord-296585-yfh5d4io	150	43	the	the	DT
cord-296585-yfh5d4io	150	44	airway	airway	NN
cord-296585-yfh5d4io	150	45	promote	promote	VBP
cord-296585-yfh5d4io	150	46	Th2	th2	CD
cord-296585-yfh5d4io	150	47	differentiation	differentiation	NN
cord-296585-yfh5d4io	150	48	(	(	-LRB-
cord-296585-yfh5d4io	150	49	23	23	CD
cord-296585-yfh5d4io	150	50	,	,	,
cord-296585-yfh5d4io	150	51	109	109	CD
cord-296585-yfh5d4io	150	52	)	)	-RRB-
cord-296585-yfh5d4io	150	53	.	.	.
cord-296585-yfh5d4io	151	1	Interestingly	interestingly	RB
cord-296585-yfh5d4io	151	2	,	,	,
cord-296585-yfh5d4io	151	3	in	in	IN
cord-296585-yfh5d4io	151	4	COPD	COPD	NNP
cord-296585-yfh5d4io	151	5	patients	patient	NNS
cord-296585-yfh5d4io	151	6	,	,	,
cord-296585-yfh5d4io	151	7	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	151	8	Th	Th	NNP
cord-296585-yfh5d4io	151	9	and	and	CC
cord-296585-yfh5d4io	151	10	cytotoxic	cytotoxic	JJ
cord-296585-yfh5d4io	151	11	T	t	NN
cord-296585-yfh5d4io	151	12	cells	cell	NNS
cord-296585-yfh5d4io	151	13	(	(	-LRB-
cord-296585-yfh5d4io	151	14	Tc	Tc	NNP
cord-296585-yfh5d4io	151	15	;	;	:
cord-296585-yfh5d4io	151	16	CD3	CD3	NNP
cord-296585-yfh5d4io	151	17	+	+	CC
cord-296585-yfh5d4io	151	18	CD8	CD8	NNP
cord-296585-yfh5d4io	151	19	+	+	SYM
cord-296585-yfh5d4io	151	20	)	)	-RRB-
cord-296585-yfh5d4io	151	21	express	express	VBP
cord-296585-yfh5d4io	151	22	more	more	JJR
cord-296585-yfh5d4io	151	23	CXCR3	cxcr3	IN
cord-296585-yfh5d4io	151	24	receptors	receptor	NNS
cord-296585-yfh5d4io	151	25	compared	compare	VBN
cord-296585-yfh5d4io	151	26	to	to	IN
cord-296585-yfh5d4io	151	27	healthy	healthy	JJ
cord-296585-yfh5d4io	151	28	individuals	individual	NNS
cord-296585-yfh5d4io	151	29	(	(	-LRB-
cord-296585-yfh5d4io	151	30	110	110	CD
cord-296585-yfh5d4io	151	31	,	,	,
cord-296585-yfh5d4io	151	32	111	111	CD
cord-296585-yfh5d4io	151	33	)	)	-RRB-
cord-296585-yfh5d4io	151	34	.	.	.
cord-296585-yfh5d4io	152	1	This	this	DT
cord-296585-yfh5d4io	152	2	enhances	enhance	VBZ
cord-296585-yfh5d4io	152	3	their	-PRON-	PRP$
cord-296585-yfh5d4io	152	4	migration	migration	NN
cord-296585-yfh5d4io	152	5	toward	toward	IN
cord-296585-yfh5d4io	152	6	chemoattractants	chemoattractants	NNP
cord-296585-yfh5d4io	152	7	CXCL9	CXCL9	NNP
cord-296585-yfh5d4io	152	8	,	,	,
cord-296585-yfh5d4io	152	9	CXCL10	CXCL10	NNP
cord-296585-yfh5d4io	152	10	,	,	,
cord-296585-yfh5d4io	152	11	and	and	CC
cord-296585-yfh5d4io	152	12	CXCL11	CXCL11	NNP
cord-296585-yfh5d4io	152	13	that	that	WDT
cord-296585-yfh5d4io	152	14	are	be	VBP
cord-296585-yfh5d4io	152	15	actively	actively	RB
cord-296585-yfh5d4io	152	16	released	release	VBN
cord-296585-yfh5d4io	152	17	by	by	IN
cord-296585-yfh5d4io	152	18	alveolar	alveolar	JJ
cord-296585-yfh5d4io	152	19	macrophages	macrophage	NNS
cord-296585-yfh5d4io	152	20	in	in	IN
cord-296585-yfh5d4io	152	21	COPD	COPD	NNP
cord-296585-yfh5d4io	152	22	subjects	subject	NNS
cord-296585-yfh5d4io	152	23	.	.	.
cord-296585-yfh5d4io	153	1	Activated	activate	VBN
cord-296585-yfh5d4io	153	2	CD8	CD8	NNP
cord-296585-yfh5d4io	153	3	+	+	CC
cord-296585-yfh5d4io	153	4	T	T	NNP
cord-296585-yfh5d4io	153	5	cell	cell	NN
cord-296585-yfh5d4io	153	6	subset	subset	NN
cord-296585-yfh5d4io	153	7	type	type	NN
cord-296585-yfh5d4io	153	8	1	1	CD
cord-296585-yfh5d4io	153	9	(	(	-LRB-
cord-296585-yfh5d4io	153	10	Tc1	tc1	CD
cord-296585-yfh5d4io	153	11	)	)	-RRB-
cord-296585-yfh5d4io	153	12	releases	release	VBZ
cord-296585-yfh5d4io	153	13	perforins	perforin	NNS
cord-296585-yfh5d4io	153	14	,	,	,
cord-296585-yfh5d4io	153	15	granzyme	granzyme	NNP
cord-296585-yfh5d4io	153	16	B	B	NNP
cord-296585-yfh5d4io	153	17	,	,	,
cord-296585-yfh5d4io	153	18	and	and	CC
cord-296585-yfh5d4io	153	19	TNF	TNF	NNP
cord-296585-yfh5d4io	153	20	-	-	HYPH
cord-296585-yfh5d4io	153	21	α	α	NN
cord-296585-yfh5d4io	153	22	to	to	TO
cord-296585-yfh5d4io	153	23	induce	induce	VB
cord-296585-yfh5d4io	153	24	alveolar	alveolar	JJ
cord-296585-yfh5d4io	153	25	cells	cell	NNS
cord-296585-yfh5d4io	153	26	apoptosis	apoptosis	NN
cord-296585-yfh5d4io	153	27	,	,	,
cord-296585-yfh5d4io	153	28	contributing	contribute	VBG
cord-296585-yfh5d4io	153	29	to	to	IN
cord-296585-yfh5d4io	153	30	the	the	DT
cord-296585-yfh5d4io	153	31	emphysema	emphysema	NN
cord-296585-yfh5d4io	153	32	(	(	-LRB-
cord-296585-yfh5d4io	153	33	112	112	CD
cord-296585-yfh5d4io	153	34	)	)	-RRB-
cord-296585-yfh5d4io	153	35	.	.	.
cord-296585-yfh5d4io	154	1	In	in	IN
cord-296585-yfh5d4io	154	2	parallel	parallel	JJ
cord-296585-yfh5d4io	154	3	,	,	,
cord-296585-yfh5d4io	154	4	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	154	5	Th17	th17	NN
cord-296585-yfh5d4io	155	1	T	t	NN
cord-296585-yfh5d4io	155	2	cells	cell	NNS
cord-296585-yfh5d4io	155	3	are	be	VBP
cord-296585-yfh5d4io	155	4	activated	activate	VBN
cord-296585-yfh5d4io	155	5	by	by	IN
cord-296585-yfh5d4io	155	6	alveolar	alveolar	JJ
cord-296585-yfh5d4io	155	7	macrophage	macrophage	NN
cord-296585-yfh5d4io	155	8	-	-	HYPH
cord-296585-yfh5d4io	155	9	derived	derive	VBN
cord-296585-yfh5d4io	155	10	IL-6	IL-6	NNP
cord-296585-yfh5d4io	155	11	and	and	CC
cord-296585-yfh5d4io	155	12	IL-23	IL-23	NNP
cord-296585-yfh5d4io	155	13	to	to	TO
cord-296585-yfh5d4io	155	14	secrete	secrete	VB
cord-296585-yfh5d4io	155	15	IL-17A	IL-17A	NNP
cord-296585-yfh5d4io	155	16	and	and	CC
cord-296585-yfh5d4io	155	17	IL-22	IL-22	NNP
cord-296585-yfh5d4io	155	18	causing	cause	VBG
cord-296585-yfh5d4io	155	19	neutrophilic	neutrophilic	JJ
cord-296585-yfh5d4io	155	20	inflammation	inflammation	NN
cord-296585-yfh5d4io	155	21	(	(	-LRB-
cord-296585-yfh5d4io	155	22	113	113	CD
cord-296585-yfh5d4io	155	23	,	,	,
cord-296585-yfh5d4io	155	24	114	114	CD
cord-296585-yfh5d4io	155	25	)	)	-RRB-
cord-296585-yfh5d4io	155	26	.	.	.
cord-296585-yfh5d4io	156	1	Inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	156	2	cytokines	cytokine	NNS
cord-296585-yfh5d4io	156	3	are	be	VBP
cord-296585-yfh5d4io	156	4	also	also	RB
cord-296585-yfh5d4io	156	5	released	release	VBN
cord-296585-yfh5d4io	156	6	by	by	IN
cord-296585-yfh5d4io	156	7	type	type	NN
cord-296585-yfh5d4io	156	8	3	3	CD
cord-296585-yfh5d4io	156	9	FIGURE	figure	NN
cord-296585-yfh5d4io	156	10	2	2	CD
cord-296585-yfh5d4io	156	11	|	|	NNP
cord-296585-yfh5d4io	156	12	Non	non	JJ
cord-296585-yfh5d4io	156	13	-	-	JJ
cord-296585-yfh5d4io	156	14	typeable	typeable	JJ
cord-296585-yfh5d4io	156	15	H.	h.	NN
cord-296585-yfh5d4io	156	16	influenzae	influenzae	NN
cord-296585-yfh5d4io	156	17	-	-	HYPH
cord-296585-yfh5d4io	156	18	dependent	dependent	JJ
cord-296585-yfh5d4io	156	19	immune	immune	JJ
cord-296585-yfh5d4io	156	20	responses	response	NNS
cord-296585-yfh5d4io	156	21	in	in	IN
cord-296585-yfh5d4io	156	22	the	the	DT
cord-296585-yfh5d4io	156	23	lower	low	JJR
cord-296585-yfh5d4io	156	24	airway	airway	NN
cord-296585-yfh5d4io	156	25	of	of	IN
cord-296585-yfh5d4io	156	26	COPD	COPD	NNP
cord-296585-yfh5d4io	156	27	patients	patient	NNS
cord-296585-yfh5d4io	156	28	result	result	VBP
cord-296585-yfh5d4io	156	29	in	in	IN
cord-296585-yfh5d4io	156	30	inflammation	inflammation	NN
cord-296585-yfh5d4io	156	31	.	.	.
cord-296585-yfh5d4io	157	1	Airway	airway	NN
cord-296585-yfh5d4io	157	2	epithelium	epithelium	NN
cord-296585-yfh5d4io	157	3	exposed	expose	VBN
cord-296585-yfh5d4io	157	4	to	to	IN
cord-296585-yfh5d4io	157	5	cigarette	cigarette	NN
cord-296585-yfh5d4io	157	6	or	or	CC
cord-296585-yfh5d4io	157	7	tobacco	tobacco	NN
cord-296585-yfh5d4io	157	8	smoke	smoke	NN
cord-296585-yfh5d4io	157	9	display	display	VB
cord-296585-yfh5d4io	157	10	an	an	DT
cord-296585-yfh5d4io	157	11	increased	increase	VBN
cord-296585-yfh5d4io	157	12	permeability	permeability	NN
cord-296585-yfh5d4io	157	13	with	with	IN
cord-296585-yfh5d4io	157	14	compromised	compromise	VBN
cord-296585-yfh5d4io	157	15	tight	tight	JJ
cord-296585-yfh5d4io	157	16	junctions	junction	NNS
cord-296585-yfh5d4io	157	17	,	,	,
cord-296585-yfh5d4io	157	18	and	and	CC
cord-296585-yfh5d4io	157	19	airway	airway	NN
cord-296585-yfh5d4io	157	20	remodeling	remodeling	NN
cord-296585-yfh5d4io	157	21	(	(	-LRB-
cord-296585-yfh5d4io	157	22	goblet	goblet	NN
cord-296585-yfh5d4io	157	23	cell	cell	NN
cord-296585-yfh5d4io	157	24	hyperplasia	hyperplasia	NN
cord-296585-yfh5d4io	157	25	and	and	CC
cord-296585-yfh5d4io	157	26	small	small	JJ
cord-296585-yfh5d4io	157	27	airway	airway	NN
cord-296585-yfh5d4io	157	28	squamous	squamous	JJ
cord-296585-yfh5d4io	157	29	metaplasia	metaplasia	NN
cord-296585-yfh5d4io	157	30	)	)	-RRB-
cord-296585-yfh5d4io	157	31	.	.	.
cord-296585-yfh5d4io	158	1	Cigarette	cigarette	NN
cord-296585-yfh5d4io	158	2	smoke	smoke	NN
cord-296585-yfh5d4io	158	3	causes	cause	VBZ
cord-296585-yfh5d4io	158	4	the	the	DT
cord-296585-yfh5d4io	158	5	activation	activation	NN
cord-296585-yfh5d4io	158	6	of	of	IN
cord-296585-yfh5d4io	158	7	airway	airway	NN
cord-296585-yfh5d4io	158	8	epithelium	epithelium	NN
cord-296585-yfh5d4io	158	9	and	and	CC
cord-296585-yfh5d4io	158	10	alveolar	alveolar	JJ
cord-296585-yfh5d4io	158	11	macrophages	macrophage	NNS
cord-296585-yfh5d4io	158	12	.	.	.
cord-296585-yfh5d4io	159	1	The	the	DT
cord-296585-yfh5d4io	159	2	activated	activate	VBN
cord-296585-yfh5d4io	159	3	airway	airway	NN
cord-296585-yfh5d4io	159	4	structural	structural	JJ
cord-296585-yfh5d4io	159	5	and	and	CC
cord-296585-yfh5d4io	159	6	resident	resident	JJ
cord-296585-yfh5d4io	159	7	immune	immune	JJ
cord-296585-yfh5d4io	159	8	cells	cell	NNS
cord-296585-yfh5d4io	159	9	release	release	VBP
cord-296585-yfh5d4io	159	10	an	an	DT
cord-296585-yfh5d4io	159	11	array	array	NN
cord-296585-yfh5d4io	159	12	of	of	IN
cord-296585-yfh5d4io	159	13	chemotactic	chemotactic	JJ
cord-296585-yfh5d4io	159	14	factors	factor	NNS
cord-296585-yfh5d4io	159	15	responsible	responsible	JJ
cord-296585-yfh5d4io	159	16	for	for	IN
cord-296585-yfh5d4io	159	17	recruitment	recruitment	NN
cord-296585-yfh5d4io	159	18	of	of	IN
cord-296585-yfh5d4io	159	19	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	159	20	and	and	CC
cord-296585-yfh5d4io	159	21	immune	immune	JJ
cord-296585-yfh5d4io	159	22	cells	cell	NNS
cord-296585-yfh5d4io	159	23	to	to	IN
cord-296585-yfh5d4io	159	24	the	the	DT
cord-296585-yfh5d4io	159	25	lung	lung	NN
cord-296585-yfh5d4io	159	26	.	.	.
cord-296585-yfh5d4io	160	1	Activated	activate	VBN
cord-296585-yfh5d4io	160	2	epithelium	epithelium	NN
cord-296585-yfh5d4io	160	3	produces	produce	VBZ
cord-296585-yfh5d4io	160	4	TGF	TGF	NNP
cord-296585-yfh5d4io	160	5	-	-	HYPH
cord-296585-yfh5d4io	160	6	β	β	NNP
cord-296585-yfh5d4io	160	7	and	and	CC
cord-296585-yfh5d4io	160	8	FGF	FGF	NNP
cord-296585-yfh5d4io	160	9	that	that	WDT
cord-296585-yfh5d4io	160	10	triggers	trigger	VBZ
cord-296585-yfh5d4io	160	11	the	the	DT
cord-296585-yfh5d4io	160	12	production	production	NN
cord-296585-yfh5d4io	160	13	of	of	IN
cord-296585-yfh5d4io	160	14	ECM	ECM	NNP
cord-296585-yfh5d4io	160	15	molecules	molecule	NNS
cord-296585-yfh5d4io	160	16	by	by	IN
cord-296585-yfh5d4io	160	17	fibroblasts	fibroblast	NNS
cord-296585-yfh5d4io	160	18	.	.	.
cord-296585-yfh5d4io	161	1	Increased	increase	VBN
cord-296585-yfh5d4io	161	2	deposition	deposition	NN
cord-296585-yfh5d4io	161	3	of	of	IN
cord-296585-yfh5d4io	161	4	ECM	ECM	NNP
cord-296585-yfh5d4io	161	5	causes	cause	VBZ
cord-296585-yfh5d4io	161	6	progression	progression	NN
cord-296585-yfh5d4io	161	7	of	of	IN
cord-296585-yfh5d4io	161	8	fibrosis	fibrosis	NN
cord-296585-yfh5d4io	161	9	and	and	CC
cord-296585-yfh5d4io	161	10	air	air	NN
cord-296585-yfh5d4io	161	11	flow	flow	NN
cord-296585-yfh5d4io	161	12	limitation	limitation	NN
cord-296585-yfh5d4io	161	13	.	.	.
cord-296585-yfh5d4io	162	1	The	the	DT
cord-296585-yfh5d4io	162	2	chemokines	chemokine	NNS
cord-296585-yfh5d4io	162	3	CXCL1	cxcl1	NN
cord-296585-yfh5d4io	162	4	and	and	CC
cord-296585-yfh5d4io	162	5	IL-8	IL-8	NNP
cord-296585-yfh5d4io	162	6	,	,	,
cord-296585-yfh5d4io	162	7	and	and	CC
cord-296585-yfh5d4io	162	8	LTB	LTB	NNP
cord-296585-yfh5d4io	162	9	4	4	CD
cord-296585-yfh5d4io	162	10	attract	attract	VBP
cord-296585-yfh5d4io	162	11	the	the	DT
cord-296585-yfh5d4io	162	12	circulating	circulate	VBG
cord-296585-yfh5d4io	162	13	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	162	14	through	through	IN
cord-296585-yfh5d4io	162	15	the	the	DT
cord-296585-yfh5d4io	162	16	receptors	receptor	NNS
cord-296585-yfh5d4io	162	17	CXCR2	CXCR2	NNS
cord-296585-yfh5d4io	162	18	and	and	CC
cord-296585-yfh5d4io	162	19	BLT	BLT	NNP
cord-296585-yfh5d4io	162	20	1	1	CD
cord-296585-yfh5d4io	162	21	,	,	,
cord-296585-yfh5d4io	162	22	respectively	respectively	RB
cord-296585-yfh5d4io	162	23	.	.	.
cord-296585-yfh5d4io	163	1	Meanwhile	meanwhile	RB
cord-296585-yfh5d4io	163	2	,	,	,
cord-296585-yfh5d4io	163	3	CXCL1	CXCL1	NNP
cord-296585-yfh5d4io	163	4	and	and	CC
cord-296585-yfh5d4io	163	5	CCL2	CCL2	NNP
cord-296585-yfh5d4io	163	6	targeting	target	VBG
cord-296585-yfh5d4io	163	7	the	the	DT
cord-296585-yfh5d4io	163	8	receptors	receptor	NNS
cord-296585-yfh5d4io	163	9	CXCR2	CXCR2	NNS
cord-296585-yfh5d4io	163	10	and	and	CC
cord-296585-yfh5d4io	163	11	CCR2	CCR2	NNP
cord-296585-yfh5d4io	163	12	on	on	IN
cord-296585-yfh5d4io	163	13	blood	blood	NN
cord-296585-yfh5d4io	163	14	monocytes	monocyte	NNS
cord-296585-yfh5d4io	163	15	are	be	VBP
cord-296585-yfh5d4io	163	16	also	also	RB
cord-296585-yfh5d4io	163	17	released	release	VBN
cord-296585-yfh5d4io	163	18	.	.	.
cord-296585-yfh5d4io	164	1	Recruited	recruit	VBN
cord-296585-yfh5d4io	164	2	blood	blood	NN
cord-296585-yfh5d4io	164	3	monocytes	monocyte	NNS
cord-296585-yfh5d4io	164	4	differentiate	differentiate	VBP
cord-296585-yfh5d4io	164	5	into	into	IN
cord-296585-yfh5d4io	164	6	macrophages	macrophage	NNS
cord-296585-yfh5d4io	164	7	in	in	IN
cord-296585-yfh5d4io	164	8	the	the	DT
cord-296585-yfh5d4io	164	9	airway	airway	NN
cord-296585-yfh5d4io	164	10	tissue	tissue	NN
cord-296585-yfh5d4io	164	11	.	.	.
cord-296585-yfh5d4io	165	1	Activated	activate	VBN
cord-296585-yfh5d4io	165	2	alveolar	alveolar	NN
cord-296585-yfh5d4io	165	3	macrophage	macrophage	NN
cord-296585-yfh5d4io	165	4	and	and	CC
cord-296585-yfh5d4io	165	5	epithelium	epithelium	NN
cord-296585-yfh5d4io	165	6	cell	cell	NN
cord-296585-yfh5d4io	165	7	also	also	RB
cord-296585-yfh5d4io	165	8	release	release	VBP
cord-296585-yfh5d4io	165	9	inflammasome	inflammasome	NNP
cord-296585-yfh5d4io	165	10	(	(	-LRB-
cord-296585-yfh5d4io	165	11	1L-1β	1l-1β	CD
cord-296585-yfh5d4io	165	12	and	and	CC
cord-296585-yfh5d4io	165	13	IL-18	IL-18	NNP
cord-296585-yfh5d4io	165	14	)	)	-RRB-
cord-296585-yfh5d4io	165	15	for	for	IN
cord-296585-yfh5d4io	165	16	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	165	17	survival	survival	NN
cord-296585-yfh5d4io	165	18	and	and	CC
cord-296585-yfh5d4io	165	19	activation	activation	NN
cord-296585-yfh5d4io	165	20	of	of	IN
cord-296585-yfh5d4io	165	21	helper	helper	NN
cord-296585-yfh5d4io	165	22	T	t	NN
cord-296585-yfh5d4io	165	23	cells	cell	NNS
cord-296585-yfh5d4io	166	1	Th17	Th17	NNP
cord-296585-yfh5d4io	166	2	.	.	.
cord-296585-yfh5d4io	167	1	The	the	DT
cord-296585-yfh5d4io	167	2	chemokine	chemokine	NN
cord-296585-yfh5d4io	167	3	IL-23	IL-23	NNP
cord-296585-yfh5d4io	167	4	are	be	VBP
cord-296585-yfh5d4io	167	5	released	release	VBN
cord-296585-yfh5d4io	167	6	by	by	IN
cord-296585-yfh5d4io	167	7	macrophages	macrophage	NNS
cord-296585-yfh5d4io	167	8	to	to	TO
cord-296585-yfh5d4io	167	9	attract	attract	VB
cord-296585-yfh5d4io	167	10	T	T	NNP
cord-296585-yfh5d4io	167	11	helper	helper	NN
cord-296585-yfh5d4io	167	12	cell	cell	NN
cord-296585-yfh5d4io	167	13	subset	subset	VBN
cord-296585-yfh5d4io	167	14	Th17	Th17	NNP
cord-296585-yfh5d4io	167	15	,	,	,
cord-296585-yfh5d4io	167	16	and	and	CC
cord-296585-yfh5d4io	167	17	ILC3	ILC3	NNP
cord-296585-yfh5d4io	167	18	.	.	.
cord-296585-yfh5d4io	168	1	Both	both	DT
cord-296585-yfh5d4io	168	2	Th17	Th17	NNP
cord-296585-yfh5d4io	168	3	and	and	CC
cord-296585-yfh5d4io	168	4	ILC3	ILC3	NNP
cord-296585-yfh5d4io	168	5	will	will	MD
cord-296585-yfh5d4io	168	6	release	release	VB
cord-296585-yfh5d4io	168	7	IL-17	IL-17	NNP
cord-296585-yfh5d4io	168	8	and	and	CC
cord-296585-yfh5d4io	168	9	IL-22	IL-22	NNP
cord-296585-yfh5d4io	168	10	that	that	WDT
cord-296585-yfh5d4io	168	11	will	will	MD
cord-296585-yfh5d4io	168	12	act	act	VB
cord-296585-yfh5d4io	168	13	on	on	IN
cord-296585-yfh5d4io	168	14	the	the	DT
cord-296585-yfh5d4io	168	15	alveolar	alveolar	JJ
cord-296585-yfh5d4io	168	16	epithelium	epithelium	NN
cord-296585-yfh5d4io	168	17	to	to	TO
cord-296585-yfh5d4io	168	18	release	release	VB
cord-296585-yfh5d4io	168	19	CXCL1	cxcl1	NN
cord-296585-yfh5d4io	169	1	and	and	CC
cord-296585-yfh5d4io	169	2	IL-8	IL-8	NNP
cord-296585-yfh5d4io	169	3	for	for	IN
cord-296585-yfh5d4io	169	4	enhanced	enhanced	JJ
cord-296585-yfh5d4io	169	5	recruitment	recruitment	NN
cord-296585-yfh5d4io	169	6	of	of	IN
cord-296585-yfh5d4io	169	7	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	169	8	,	,	,
cord-296585-yfh5d4io	169	9	resulting	result	VBG
cord-296585-yfh5d4io	169	10	in	in	IN
cord-296585-yfh5d4io	169	11	neutrophilic	neutrophilic	JJ
cord-296585-yfh5d4io	169	12	inflammation	inflammation	NN
cord-296585-yfh5d4io	169	13	.	.	.
cord-296585-yfh5d4io	170	1	Activated	activate	VBN
cord-296585-yfh5d4io	170	2	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	170	3	are	be	VBP
cord-296585-yfh5d4io	170	4	thereafter	thereafter	RB
cord-296585-yfh5d4io	170	5	degranulated	degranulate	VBN
cord-296585-yfh5d4io	170	6	and	and	CC
cord-296585-yfh5d4io	170	7	release	release	NN
cord-296585-yfh5d4io	170	8	myeloperoxidase	myeloperoxidase	NNP
cord-296585-yfh5d4io	170	9	(	(	-LRB-
cord-296585-yfh5d4io	170	10	MPO	MPO	NNP
cord-296585-yfh5d4io	170	11	)	)	-RRB-
cord-296585-yfh5d4io	170	12	,	,	,
cord-296585-yfh5d4io	170	13	lipocalin	lipocalin	NN
cord-296585-yfh5d4io	170	14	,	,	,
cord-296585-yfh5d4io	170	15	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	170	16	elastase	elastase	NN
cord-296585-yfh5d4io	170	17	(	(	-LRB-
cord-296585-yfh5d4io	170	18	NE	NE	NNP
cord-296585-yfh5d4io	170	19	)	)	-RRB-
cord-296585-yfh5d4io	170	20	,	,	,
cord-296585-yfh5d4io	170	21	cathepsin	cathepsin	NN
cord-296585-yfh5d4io	170	22	-	-	HYPH
cord-296585-yfh5d4io	170	23	G	g	NN
cord-296585-yfh5d4io	170	24	(	(	-LRB-
cord-296585-yfh5d4io	170	25	CG	CG	NNP
cord-296585-yfh5d4io	170	26	)	)	-RRB-
cord-296585-yfh5d4io	170	27	,	,	,
cord-296585-yfh5d4io	170	28	proteinase-3	proteinase-3	NNP
cord-296585-yfh5d4io	170	29	(	(	-LRB-
cord-296585-yfh5d4io	170	30	Prot-3	Prot-3	NNP
cord-296585-yfh5d4io	170	31	)	)	-RRB-
cord-296585-yfh5d4io	170	32	,	,	,
cord-296585-yfh5d4io	170	33	and	and	CC
cord-296585-yfh5d4io	170	34	matrix	matrix	NNP
cord-296585-yfh5d4io	170	35	metalloprotease	metalloprotease	NNP
cord-296585-yfh5d4io	170	36	(	(	-LRB-
cord-296585-yfh5d4io	170	37	MMP	MMP	NNP
cord-296585-yfh5d4io	170	38	)	)	-RRB-
cord-296585-yfh5d4io	170	39	8	8	CD
cord-296585-yfh5d4io	170	40	and	and	CC
cord-296585-yfh5d4io	170	41	9	9	CD
cord-296585-yfh5d4io	170	42	.	.	.
cord-296585-yfh5d4io	171	1	The	the	DT
cord-296585-yfh5d4io	171	2	granulated	granulated	JJ
cord-296585-yfh5d4io	171	3	products	product	NNS
cord-296585-yfh5d4io	171	4	are	be	VBP
cord-296585-yfh5d4io	171	5	proteolytic	proteolytic	JJ
cord-296585-yfh5d4io	171	6	and	and	CC
cord-296585-yfh5d4io	171	7	elastilolytic	elastilolytic	VBN
cord-296585-yfh5d4io	171	8	to	to	IN
cord-296585-yfh5d4io	171	9	aveolar	aveolar	NNP
cord-296585-yfh5d4io	171	10	,	,	,
cord-296585-yfh5d4io	171	11	causing	cause	VBG
cord-296585-yfh5d4io	171	12	alveolar	alveolar	JJ
cord-296585-yfh5d4io	171	13	destruction	destruction	NN
cord-296585-yfh5d4io	171	14	and	and	CC
cord-296585-yfh5d4io	171	15	emphysema	emphysema	NN
cord-296585-yfh5d4io	171	16	.	.	.
cord-296585-yfh5d4io	172	1	In	in	IN
cord-296585-yfh5d4io	172	2	addition	addition	NN
cord-296585-yfh5d4io	172	3	,	,	,
cord-296585-yfh5d4io	172	4	NE	NE	NNP
cord-296585-yfh5d4io	172	5	,	,	,
cord-296585-yfh5d4io	172	6	CG	CG	NNP
cord-296585-yfh5d4io	172	7	,	,	,
cord-296585-yfh5d4io	172	8	and	and	CC
cord-296585-yfh5d4io	172	9	Prot-3	Prot-3	NNP
cord-296585-yfh5d4io	172	10	are	be	VBP
cord-296585-yfh5d4io	172	11	also	also	RB
cord-296585-yfh5d4io	172	12	targeting	target	VBG
cord-296585-yfh5d4io	172	13	goblet	goblet	NN
cord-296585-yfh5d4io	172	14	cells	cell	NNS
cord-296585-yfh5d4io	172	15	and	and	CC
cord-296585-yfh5d4io	172	16	submucosal	submucosal	NN
cord-296585-yfh5d4io	172	17	glands	gland	NNS
cord-296585-yfh5d4io	172	18	to	to	TO
cord-296585-yfh5d4io	172	19	induce	induce	VB
cord-296585-yfh5d4io	172	20	hypersecretion	hypersecretion	NN
cord-296585-yfh5d4io	172	21	of	of	IN
cord-296585-yfh5d4io	172	22	mucus	mucus	NN
cord-296585-yfh5d4io	172	23	.	.	.
cord-296585-yfh5d4io	173	1	Dendritic	dendritic	JJ
cord-296585-yfh5d4io	173	2	cells	cell	NNS
cord-296585-yfh5d4io	173	3	carrying	carry	VBG
cord-296585-yfh5d4io	173	4	the	the	DT
cord-296585-yfh5d4io	173	5	receptors	receptor	NNS
cord-296585-yfh5d4io	173	6	CCR2	CCR2	NNP
cord-296585-yfh5d4io	173	7	and	and	CC
cord-296585-yfh5d4io	173	8	CCR6	CCR6	NNPS
cord-296585-yfh5d4io	173	9	are	be	VBP
cord-296585-yfh5d4io	173	10	recruited	recruit	VBN
cord-296585-yfh5d4io	173	11	to	to	IN
cord-296585-yfh5d4io	173	12	airway	airway	NN
cord-296585-yfh5d4io	173	13	tissue	tissue	NN
cord-296585-yfh5d4io	173	14	via	via	IN
cord-296585-yfh5d4io	173	15	chemottractants	chemottractant	NNS
cord-296585-yfh5d4io	173	16	CCL2	CCL2	NNP
cord-296585-yfh5d4io	173	17	and	and	CC
cord-296585-yfh5d4io	173	18	CCL20	CCL20	NNP
cord-296585-yfh5d4io	173	19	.	.	.
cord-296585-yfh5d4io	174	1	The	the	DT
cord-296585-yfh5d4io	174	2	dendritic	dendritic	JJ
cord-296585-yfh5d4io	174	3	cells	cell	NNS
cord-296585-yfh5d4io	174	4	uptake	uptake	VBP
cord-296585-yfh5d4io	174	5	the	the	DT
cord-296585-yfh5d4io	174	6	antigen	antigen	NN
cord-296585-yfh5d4io	174	7	(	(	-LRB-
cord-296585-yfh5d4io	174	8	smoke	smoke	NN
cord-296585-yfh5d4io	174	9	residues	residue	NNS
cord-296585-yfh5d4io	174	10	)	)	-RRB-
cord-296585-yfh5d4io	174	11	,	,	,
cord-296585-yfh5d4io	174	12	and	and	CC
cord-296585-yfh5d4io	174	13	present	present	VB
cord-296585-yfh5d4io	174	14	the	the	DT
cord-296585-yfh5d4io	174	15	antigens	antigen	NNS
cord-296585-yfh5d4io	174	16	to	to	IN
cord-296585-yfh5d4io	174	17	the	the	DT
cord-296585-yfh5d4io	174	18	naïve	naïve	JJ
cord-296585-yfh5d4io	174	19	T	T	NNP
cord-296585-yfh5d4io	174	20	cells	cell	NNS
cord-296585-yfh5d4io	174	21	at	at	IN
cord-296585-yfh5d4io	174	22	lymph	lymph	NN
cord-296585-yfh5d4io	174	23	nodes	node	NNS
cord-296585-yfh5d4io	174	24	.	.	.
cord-296585-yfh5d4io	175	1	Uncommitted	uncommitted	JJ
cord-296585-yfh5d4io	175	2	T	t	NN
cord-296585-yfh5d4io	175	3	lymphocytes	lymphocyte	NNS
cord-296585-yfh5d4io	175	4	are	be	VBP
cord-296585-yfh5d4io	175	5	thereafter	thereafter	RB
cord-296585-yfh5d4io	175	6	primed	prime	VBN
cord-296585-yfh5d4io	175	7	to	to	IN
cord-296585-yfh5d4io	175	8	the	the	DT
cord-296585-yfh5d4io	175	9	presented	present	VBN
cord-296585-yfh5d4io	175	10	antigen	antigen	NN
cord-296585-yfh5d4io	175	11	and	and	CC
cord-296585-yfh5d4io	175	12	activated	activate	VBN
cord-296585-yfh5d4io	175	13	by	by	IN
cord-296585-yfh5d4io	175	14	IL-12	IL-12	NNP
cord-296585-yfh5d4io	175	15	derived	derive	VBN
cord-296585-yfh5d4io	175	16	from	from	IN
cord-296585-yfh5d4io	175	17	dendritic	dendritic	JJ
cord-296585-yfh5d4io	175	18	cells	cell	NNS
cord-296585-yfh5d4io	175	19	(	(	-LRB-
cord-296585-yfh5d4io	175	20	professional	professional	JJ
cord-296585-yfh5d4io	175	21	antigen	antigen	NN
cord-296585-yfh5d4io	175	22	presenting	present	VBG
cord-296585-yfh5d4io	175	23	cells	cell	NNS
cord-296585-yfh5d4io	175	24	;	;	:
cord-296585-yfh5d4io	175	25	APC	APC	NNP
cord-296585-yfh5d4io	175	26	)	)	-RRB-
cord-296585-yfh5d4io	175	27	.	.	.
cord-296585-yfh5d4io	176	1	Mature	Mature	NNP
cord-296585-yfh5d4io	176	2	/	/	SYM
cord-296585-yfh5d4io	176	3	activated	activate	VBN
cord-296585-yfh5d4io	176	4	T	T	NNP
cord-296585-yfh5d4io	176	5	cells	cell	NNS
cord-296585-yfh5d4io	176	6	expressing	express	VBG
cord-296585-yfh5d4io	176	7	receptor	receptor	NN
cord-296585-yfh5d4io	176	8	CXCR3	CXCR3	NNS
cord-296585-yfh5d4io	176	9	are	be	VBP
cord-296585-yfh5d4io	176	10	chemotactic	chemotactic	VBN
cord-296585-yfh5d4io	176	11	toward	toward	IN
cord-296585-yfh5d4io	176	12	CXCL9	CXCL9	NNP
cord-296585-yfh5d4io	176	13	,	,	,
cord-296585-yfh5d4io	176	14	CXCL10	CXCL10	NNP
cord-296585-yfh5d4io	176	15	,	,	,
cord-296585-yfh5d4io	176	16	and	and	CC
cord-296585-yfh5d4io	176	17	CXCL11	CXCL11	NNP
cord-296585-yfh5d4io	176	18	and	and	CC
cord-296585-yfh5d4io	176	19	are	be	VBP
cord-296585-yfh5d4io	176	20	recruited	recruit	VBN
cord-296585-yfh5d4io	176	21	to	to	IN
cord-296585-yfh5d4io	176	22	the	the	DT
cord-296585-yfh5d4io	176	23	lung	lung	NN
cord-296585-yfh5d4io	176	24	tissue	tissue	NN
cord-296585-yfh5d4io	176	25	.	.	.
cord-296585-yfh5d4io	177	1	Cytotoxic	Cytotoxic	NNP
cord-296585-yfh5d4io	177	2	CD8	CD8	NNP
cord-296585-yfh5d4io	177	3	+	+	CC
cord-296585-yfh5d4io	177	4	T	T	NNP
cord-296585-yfh5d4io	177	5	cell	cell	NN
cord-296585-yfh5d4io	177	6	subtype	subtype	NN
cord-296585-yfh5d4io	177	7	Tc1	tc1	CD
cord-296585-yfh5d4io	177	8	releases	release	NNS
cord-296585-yfh5d4io	177	9	perforin	perforin	NNP
cord-296585-yfh5d4io	177	10	and	and	CC
cord-296585-yfh5d4io	177	11	granzyme	granzyme	NNS
cord-296585-yfh5d4io	177	12	B	B	NNP
cord-296585-yfh5d4io	178	1	resulting	result	VBG
cord-296585-yfh5d4io	178	2	in	in	IN
cord-296585-yfh5d4io	178	3	epithelial	epithelial	JJ
cord-296585-yfh5d4io	178	4	apoptosis	apoptosis	NN
cord-296585-yfh5d4io	178	5	contributing	contribute	VBG
cord-296585-yfh5d4io	178	6	to	to	IN
cord-296585-yfh5d4io	178	7	emphysema	emphysema	NN
cord-296585-yfh5d4io	178	8	progression	progression	NN
cord-296585-yfh5d4io	178	9	.	.	.
cord-296585-yfh5d4io	179	1	For	for	IN
cord-296585-yfh5d4io	179	2	the	the	DT
cord-296585-yfh5d4io	179	3	humoral	humoral	JJ
cord-296585-yfh5d4io	179	4	immune	immune	JJ
cord-296585-yfh5d4io	179	5	response	response	NN
cord-296585-yfh5d4io	179	6	,	,	,
cord-296585-yfh5d4io	179	7	B	b	NN
cord-296585-yfh5d4io	179	8	cells	cell	NNS
cord-296585-yfh5d4io	179	9	are	be	VBP
cord-296585-yfh5d4io	179	10	activated	activate	VBN
cord-296585-yfh5d4io	179	11	by	by	IN
cord-296585-yfh5d4io	179	12	Th2	Th2	NNP
cord-296585-yfh5d4io	179	13	,	,	,
cord-296585-yfh5d4io	179	14	enter	enter	VB
cord-296585-yfh5d4io	179	15	the	the	DT
cord-296585-yfh5d4io	179	16	circulation	circulation	NN
cord-296585-yfh5d4io	179	17	via	via	IN
cord-296585-yfh5d4io	179	18	high	high	JJ
cord-296585-yfh5d4io	179	19	-	-	HYPH
cord-296585-yfh5d4io	179	20	endothelial	endothelial	JJ
cord-296585-yfh5d4io	179	21	venule	venule	NN
cord-296585-yfh5d4io	179	22	(	(	-LRB-
cord-296585-yfh5d4io	179	23	HEV)-like	hev)-like	DT
cord-296585-yfh5d4io	179	24	vessel	vessel	NN
cord-296585-yfh5d4io	179	25	and	and	CC
cord-296585-yfh5d4io	179	26	transported	transport	VBN
cord-296585-yfh5d4io	179	27	to	to	IN
cord-296585-yfh5d4io	179	28	lung	lung	NN
cord-296585-yfh5d4io	179	29	tissue	tissue	NN
cord-296585-yfh5d4io	179	30	,	,	,
cord-296585-yfh5d4io	179	31	and	and	CC
cord-296585-yfh5d4io	179	32	organized	organize	VBN
cord-296585-yfh5d4io	179	33	into	into	IN
cord-296585-yfh5d4io	179	34	lymphoid	lymphoid	JJ
cord-296585-yfh5d4io	179	35	follicles	follicle	NNS
cord-296585-yfh5d4io	179	36	at	at	IN
cord-296585-yfh5d4io	179	37	peripheral	peripheral	JJ
cord-296585-yfh5d4io	179	38	airway	airway	NN
cord-296585-yfh5d4io	179	39	.	.	.
cord-296585-yfh5d4io	180	1	B	b	NN
cord-296585-yfh5d4io	180	2	cell	cell	NN
cord-296585-yfh5d4io	180	3	-	-	HYPH
cord-296585-yfh5d4io	180	4	derived	derive	VBN
cord-296585-yfh5d4io	180	5	plasma	plasma	NN
cord-296585-yfh5d4io	180	6	cells	cell	NNS
cord-296585-yfh5d4io	180	7	from	from	IN
cord-296585-yfh5d4io	180	8	lymphoid	lymphoid	JJ
cord-296585-yfh5d4io	180	9	follicles	follicle	NNS
cord-296585-yfh5d4io	180	10	release	release	VBP
cord-296585-yfh5d4io	180	11	IgA	IgA	NNP
cord-296585-yfh5d4io	180	12	,	,	,
cord-296585-yfh5d4io	180	13	and	and	CC
cord-296585-yfh5d4io	180	14	secreted	secrete	VBD
cord-296585-yfh5d4io	180	15	into	into	IN
cord-296585-yfh5d4io	180	16	airway	airway	NN
cord-296585-yfh5d4io	180	17	lumen	lumen	NN
cord-296585-yfh5d4io	180	18	as	as	IN
cord-296585-yfh5d4io	180	19	secretory	secretory	JJ
cord-296585-yfh5d4io	180	20	IgA	IgA	NNP
cord-296585-yfh5d4io	180	21	(	(	-LRB-
cord-296585-yfh5d4io	180	22	sIgA	sIgA	NNP
cord-296585-yfh5d4io	180	23	)	)	-RRB-
cord-296585-yfh5d4io	180	24	via	via	IN
cord-296585-yfh5d4io	180	25	the	the	DT
cord-296585-yfh5d4io	180	26	polymeric	polymeric	JJ
cord-296585-yfh5d4io	180	27	immunoglobulin	immunoglobulin	NN
cord-296585-yfh5d4io	180	28	receptor	receptor	NN
cord-296585-yfh5d4io	180	29	.	.	.
cord-296585-yfh5d4io	181	1	Mucosal	Mucosal	NNP
cord-296585-yfh5d4io	181	2	antibodies	antibody	NNS
cord-296585-yfh5d4io	181	3	play	play	VBP
cord-296585-yfh5d4io	181	4	an	an	DT
cord-296585-yfh5d4io	181	5	important	important	JJ
cord-296585-yfh5d4io	181	6	role	role	NN
cord-296585-yfh5d4io	181	7	to	to	TO
cord-296585-yfh5d4io	181	8	eradicate	eradicate	VB
cord-296585-yfh5d4io	181	9	pathogens	pathogen	NNS
cord-296585-yfh5d4io	181	10	and	and	CC
cord-296585-yfh5d4io	181	11	noxious	noxious	JJ
cord-296585-yfh5d4io	181	12	antigens	antigen	NNS
cord-296585-yfh5d4io	181	13	via	via	IN
cord-296585-yfh5d4io	181	14	immune	immune	JJ
cord-296585-yfh5d4io	181	15	exclusion	exclusion	NN
cord-296585-yfh5d4io	181	16	.	.	.
cord-296585-yfh5d4io	182	1	However	however	RB
cord-296585-yfh5d4io	182	2	,	,	,
cord-296585-yfh5d4io	182	3	the	the	DT
cord-296585-yfh5d4io	182	4	airway	airway	NN
cord-296585-yfh5d4io	182	5	defense	defense	NN
cord-296585-yfh5d4io	182	6	by	by	IN
cord-296585-yfh5d4io	182	7	sIgA	sIgA	NNS
cord-296585-yfh5d4io	182	8	is	be	VBZ
cord-296585-yfh5d4io	182	9	diminished	diminish	VBN
cord-296585-yfh5d4io	182	10	by	by	IN
cord-296585-yfh5d4io	182	11	NTHi	NTHi	NNS
cord-296585-yfh5d4io	182	12	IgA	IgA	NNP
cord-296585-yfh5d4io	182	13	protease	protease	NN
cord-296585-yfh5d4io	182	14	that	that	WDT
cord-296585-yfh5d4io	182	15	degrade	degrade	VBP
cord-296585-yfh5d4io	182	16	the	the	DT
cord-296585-yfh5d4io	182	17	antibodies	antibody	NNS
cord-296585-yfh5d4io	182	18	.	.	.
cord-296585-yfh5d4io	183	1	TLR2	TLR2	NNP
cord-296585-yfh5d4io	183	2	and	and	CC
cord-296585-yfh5d4io	183	3	TLR4	TLR4	NNP
cord-296585-yfh5d4io	183	4	of	of	IN
cord-296585-yfh5d4io	183	5	the	the	DT
cord-296585-yfh5d4io	183	6	airway	airway	NN
cord-296585-yfh5d4io	183	7	phagocytes	phagocyte	NNS
cord-296585-yfh5d4io	183	8	and	and	CC
cord-296585-yfh5d4io	183	9	epithelium	epithelium	NN
cord-296585-yfh5d4io	183	10	following	follow	VBG
cord-296585-yfh5d4io	183	11	exposure	exposure	NN
cord-296585-yfh5d4io	183	12	to	to	IN
cord-296585-yfh5d4io	183	13	cigarette	cigarette	NN
cord-296585-yfh5d4io	183	14	smoke	smoke	NN
cord-296585-yfh5d4io	183	15	are	be	VBP
cord-296585-yfh5d4io	183	16	not	not	RB
cord-296585-yfh5d4io	183	17	responding	respond	VBG
cord-296585-yfh5d4io	183	18	to	to	IN
cord-296585-yfh5d4io	183	19	P6	P6	NNP
cord-296585-yfh5d4io	183	20	and	and	CC
cord-296585-yfh5d4io	183	21	LOS	LOS	NNP
cord-296585-yfh5d4io	183	22	of	of	IN
cord-296585-yfh5d4io	183	23	NTHi	NTHi	NNPS
cord-296585-yfh5d4io	183	24	.	.	.
cord-296585-yfh5d4io	184	1	This	this	DT
cord-296585-yfh5d4io	184	2	results	result	VBZ
cord-296585-yfh5d4io	184	3	in	in	IN
cord-296585-yfh5d4io	184	4	defective	defective	JJ
cord-296585-yfh5d4io	184	5	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	184	6	and	and	CC
cord-296585-yfh5d4io	184	7	delayed	delay	VBN
cord-296585-yfh5d4io	184	8	bacterial	bacterial	JJ
cord-296585-yfh5d4io	184	9	clearance	clearance	NN
cord-296585-yfh5d4io	184	10	from	from	IN
cord-296585-yfh5d4io	184	11	the	the	DT
cord-296585-yfh5d4io	184	12	airway	airway	NN
cord-296585-yfh5d4io	184	13	.	.	.
cord-296585-yfh5d4io	185	1	The	the	DT
cord-296585-yfh5d4io	185	2	suppressed	suppress	VBN
cord-296585-yfh5d4io	185	3	TLR4	TLR4	NNP
cord-296585-yfh5d4io	185	4	induction	induction	NN
cord-296585-yfh5d4io	185	5	in	in	IN
cord-296585-yfh5d4io	185	6	T	T	NNP
cord-296585-yfh5d4io	185	7	cells	cell	NNS
cord-296585-yfh5d4io	185	8	has	have	VBZ
cord-296585-yfh5d4io	185	9	also	also	RB
cord-296585-yfh5d4io	185	10	lead	lead	VB
cord-296585-yfh5d4io	185	11	to	to	IN
cord-296585-yfh5d4io	185	12	Th2	Th2	NNP
cord-296585-yfh5d4io	185	13	predominant	predominant	JJ
cord-296585-yfh5d4io	185	14	immune	immune	JJ
cord-296585-yfh5d4io	185	15	response	response	NN
cord-296585-yfh5d4io	185	16	,	,	,
cord-296585-yfh5d4io	185	17	with	with	IN
cord-296585-yfh5d4io	185	18	low	low	JJ
cord-296585-yfh5d4io	185	19	production	production	NN
cord-296585-yfh5d4io	185	20	of	of	IN
cord-296585-yfh5d4io	185	21	IFN	IFN	NNP
cord-296585-yfh5d4io	185	22	-	-	HYPH
cord-296585-yfh5d4io	185	23	γ	γ	NNP
cord-296585-yfh5d4io	185	24	and	and	CC
cord-296585-yfh5d4io	185	25	reduced	reduce	VBN
cord-296585-yfh5d4io	185	26	T	T	NNP
cord-296585-yfh5d4io	185	27	cell	cell	NN
cord-296585-yfh5d4io	185	28	-	-	HYPH
cord-296585-yfh5d4io	185	29	mediated	mediate	VBN
cord-296585-yfh5d4io	185	30	immune	immune	JJ
cord-296585-yfh5d4io	185	31	killing	killing	NN
cord-296585-yfh5d4io	185	32	of	of	IN
cord-296585-yfh5d4io	185	33	NTHi	NTHi	NNS
cord-296585-yfh5d4io	185	34	.	.	.
cord-296585-yfh5d4io	186	1	Moreover	moreover	RB
cord-296585-yfh5d4io	186	2	,	,	,
cord-296585-yfh5d4io	186	3	NTHi	NTHi	NNP
cord-296585-yfh5d4io	186	4	downregulates	downregulate	VBZ
cord-296585-yfh5d4io	186	5	Foxp3	foxp3	NN
cord-296585-yfh5d4io	186	6	of	of	IN
cord-296585-yfh5d4io	186	7	Tregs	Tregs	NNP
cord-296585-yfh5d4io	186	8	and	and	CC
cord-296585-yfh5d4io	186	9	thus	thus	RB
cord-296585-yfh5d4io	186	10	impairs	impair	VBZ
cord-296585-yfh5d4io	186	11	the	the	DT
cord-296585-yfh5d4io	186	12	anti	anti	JJ
cord-296585-yfh5d4io	186	13	-	-	JJ
cord-296585-yfh5d4io	186	14	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	186	15	/	/	HYPH
cord-296585-yfh5d4io	186	16	pro	pro	JJ
cord-296585-yfh5d4io	186	17	-	-	JJ
cord-296585-yfh5d4io	186	18	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	186	19	balance	balance	NN
cord-296585-yfh5d4io	186	20	of	of	IN
cord-296585-yfh5d4io	186	21	Tregs	Tregs	NNP
cord-296585-yfh5d4io	186	22	.	.	.
cord-296585-yfh5d4io	187	1	The	the	DT
cord-296585-yfh5d4io	187	2	extensive	extensive	JJ
cord-296585-yfh5d4io	187	3	immunosuppressive	immunosuppressive	JJ
cord-296585-yfh5d4io	187	4	activity	activity	NN
cord-296585-yfh5d4io	187	5	by	by	IN
cord-296585-yfh5d4io	187	6	Tregs	Tregs	NNP
cord-296585-yfh5d4io	187	7	diminishes	diminish	VBZ
cord-296585-yfh5d4io	187	8	the	the	DT
cord-296585-yfh5d4io	187	9	response	response	NN
cord-296585-yfh5d4io	187	10	of	of	IN
cord-296585-yfh5d4io	187	11	effector	effector	NN
cord-296585-yfh5d4io	187	12	T	t	NN
cord-296585-yfh5d4io	187	13	to	to	IN
cord-296585-yfh5d4io	187	14	(	(	-LRB-
cord-296585-yfh5d4io	187	15	Continued	continued	JJ
cord-296585-yfh5d4io	187	16	)	)	-RRB-
cord-296585-yfh5d4io	187	17	FIGURE	figure	NN
cord-296585-yfh5d4io	187	18	2	2	CD
cord-296585-yfh5d4io	187	19	|	|	NNS
cord-296585-yfh5d4io	187	20	NTHi	nthi	NN
cord-296585-yfh5d4io	187	21	stimulation	stimulation	NN
cord-296585-yfh5d4io	187	22	.	.	.
cord-296585-yfh5d4io	188	1	Lastly	lastly	RB
cord-296585-yfh5d4io	188	2	,	,	,
cord-296585-yfh5d4io	188	3	plasma	plasma	NN
cord-296585-yfh5d4io	188	4	cells	cell	NNS
cord-296585-yfh5d4io	188	5	from	from	IN
cord-296585-yfh5d4io	188	6	COPD	COPD	NNP
cord-296585-yfh5d4io	188	7	patients	patient	NNS
cord-296585-yfh5d4io	188	8	fail	fail	VBP
cord-296585-yfh5d4io	188	9	to	to	TO
cord-296585-yfh5d4io	188	10	produce	produce	VB
cord-296585-yfh5d4io	188	11	NTHi	NTHi	NNS
cord-296585-yfh5d4io	188	12	-	-	HYPH
cord-296585-yfh5d4io	188	13	specific	specific	JJ
cord-296585-yfh5d4io	188	14	antibodies	antibody	NNS
cord-296585-yfh5d4io	188	15	and	and	CC
cord-296585-yfh5d4io	188	16	compromised	compromise	VBN
cord-296585-yfh5d4io	188	17	immunoglobulin	immunoglobulin	NN
cord-296585-yfh5d4io	188	18	class	class	NN
cord-296585-yfh5d4io	188	19	switching	switching	NN
cord-296585-yfh5d4io	188	20	.	.	.
cord-296585-yfh5d4io	189	1	The	the	DT
cord-296585-yfh5d4io	189	2	impairment	impairment	NN
cord-296585-yfh5d4io	189	3	of	of	IN
cord-296585-yfh5d4io	189	4	the	the	DT
cord-296585-yfh5d4io	189	5	host	host	NN
cord-296585-yfh5d4io	189	6	immune	immune	JJ
cord-296585-yfh5d4io	189	7	response	response	NN
cord-296585-yfh5d4io	189	8	in	in	IN
cord-296585-yfh5d4io	189	9	COPD	COPD	NNP
cord-296585-yfh5d4io	189	10	toward	toward	IN
cord-296585-yfh5d4io	189	11	NTHi	NTHi	NNS
cord-296585-yfh5d4io	189	12	infection	infection	NN
cord-296585-yfh5d4io	189	13	are	be	VBP
cord-296585-yfh5d4io	189	14	labeled	label	VBN
cord-296585-yfh5d4io	189	15	in	in	IN
cord-296585-yfh5d4io	189	16	blue	blue	JJ
cord-296585-yfh5d4io	189	17	.	.	.
cord-296585-yfh5d4io	190	1	In	in	IN
cord-296585-yfh5d4io	190	2	total	total	JJ
cord-296585-yfh5d4io	190	3	,	,	,
cord-296585-yfh5d4io	190	4	NTHi	nthi	JJ
cord-296585-yfh5d4io	190	5	infection	infection	NN
cord-296585-yfh5d4io	190	6	in	in	IN
cord-296585-yfh5d4io	190	7	COPD	COPD	NNP
cord-296585-yfh5d4io	190	8	lung	lung	NN
cord-296585-yfh5d4io	190	9	adversely	adversely	RB
cord-296585-yfh5d4io	190	10	reduces	reduce	VBZ
cord-296585-yfh5d4io	190	11	the	the	DT
cord-296585-yfh5d4io	190	12	production	production	NN
cord-296585-yfh5d4io	190	13	of	of	IN
cord-296585-yfh5d4io	190	14	IL-1β	il-1β	NN
cord-296585-yfh5d4io	190	15	,	,	,
cord-296585-yfh5d4io	190	16	IL-6	IL-6	NNP
cord-296585-yfh5d4io	190	17	,	,	,
cord-296585-yfh5d4io	190	18	IL-8	IL-8	NNP
cord-296585-yfh5d4io	190	19	,	,	,
cord-296585-yfh5d4io	190	20	CXCL-10	cxcl-10	NN
cord-296585-yfh5d4io	190	21	,	,	,
cord-296585-yfh5d4io	190	22	IL-22	IL-22	NNP
cord-296585-yfh5d4io	190	23	,	,	,
cord-296585-yfh5d4io	191	1	TNF	TNF	NNP
cord-296585-yfh5d4io	191	2	-	-	HYPH
cord-296585-yfh5d4io	191	3	α	α	NNP
cord-296585-yfh5d4io	191	4	,	,	,
cord-296585-yfh5d4io	191	5	antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	191	6	peptide	peptide	NN
cord-296585-yfh5d4io	191	7	(	(	-LRB-
cord-296585-yfh5d4io	191	8	AMP	AMP	NNP
cord-296585-yfh5d4io	191	9	)	)	-RRB-
cord-296585-yfh5d4io	191	10	,	,	,
cord-296585-yfh5d4io	191	11	and	and	CC
cord-296585-yfh5d4io	191	12	IFN	IFN	NNP
cord-296585-yfh5d4io	191	13	-	-	HYPH
cord-296585-yfh5d4io	191	14	γ	γ	NNP
cord-296585-yfh5d4io	191	15	.	.	.
cord-296585-yfh5d4io	192	1	This	this	DT
cord-296585-yfh5d4io	192	2	may	may	MD
cord-296585-yfh5d4io	192	3	explain	explain	VB
cord-296585-yfh5d4io	192	4	the	the	DT
cord-296585-yfh5d4io	192	5	inefficient	inefficient	JJ
cord-296585-yfh5d4io	192	6	eradication	eradication	NN
cord-296585-yfh5d4io	192	7	of	of	IN
cord-296585-yfh5d4io	192	8	airway	airway	NN
cord-296585-yfh5d4io	192	9	pathogens	pathogen	NNS
cord-296585-yfh5d4io	192	10	in	in	IN
cord-296585-yfh5d4io	192	11	COPD	COPD	NNP
cord-296585-yfh5d4io	192	12	patients	patient	NNS
cord-296585-yfh5d4io	192	13	whereby	whereby	VBZ
cord-296585-yfh5d4io	192	14	persistent	persistent	JJ
cord-296585-yfh5d4io	192	15	NTHi	NTHi	NNS
cord-296585-yfh5d4io	192	16	infection	infection	NN
cord-296585-yfh5d4io	192	17	concomitantly	concomitantly	RB
cord-296585-yfh5d4io	192	18	escalates	escalate	VBZ
cord-296585-yfh5d4io	192	19	the	the	DT
cord-296585-yfh5d4io	192	20	inflammation	inflammation	NN
cord-296585-yfh5d4io	192	21	and	and	CC
cord-296585-yfh5d4io	192	22	thus	thus	RB
cord-296585-yfh5d4io	192	23	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	192	24	in	in	IN
cord-296585-yfh5d4io	192	25	COPD	COPD	NNP
cord-296585-yfh5d4io	192	26	.	.	.
cord-296585-yfh5d4io	193	1	innate	innate	JJ
cord-296585-yfh5d4io	193	2	lymphoid	lymphoid	JJ
cord-296585-yfh5d4io	193	3	cells	cell	NNS
cord-296585-yfh5d4io	193	4	(	(	-LRB-
cord-296585-yfh5d4io	193	5	ILC3	ILC3	NNP
cord-296585-yfh5d4io	193	6	)	)	-RRB-
cord-296585-yfh5d4io	193	7	(	(	-LRB-
cord-296585-yfh5d4io	193	8	115	115	CD
cord-296585-yfh5d4io	193	9	)	)	-RRB-
cord-296585-yfh5d4io	193	10	.	.	.
cord-296585-yfh5d4io	194	1	The	the	DT
cord-296585-yfh5d4io	194	2	ILCs	ilc	NNS
cord-296585-yfh5d4io	194	3	are	be	VBP
cord-296585-yfh5d4io	194	4	involved	involve	VBN
cord-296585-yfh5d4io	194	5	in	in	IN
cord-296585-yfh5d4io	194	6	the	the	DT
cord-296585-yfh5d4io	194	7	homeostasis	homeostasis	NN
cord-296585-yfh5d4io	194	8	of	of	IN
cord-296585-yfh5d4io	194	9	lung	lung	NN
cord-296585-yfh5d4io	194	10	immunity	immunity	NN
cord-296585-yfh5d4io	194	11	and	and	CC
cord-296585-yfh5d4io	194	12	are	be	VBP
cord-296585-yfh5d4io	194	13	regulated	regulate	VBN
cord-296585-yfh5d4io	194	14	by	by	IN
cord-296585-yfh5d4io	194	15	epithelially	epithelially	RB
cord-296585-yfh5d4io	194	16	produced	produce	VBN
cord-296585-yfh5d4io	194	17	IL-33	IL-33	NNP
cord-296585-yfh5d4io	195	1	and	and	CC
cord-296585-yfh5d4io	195	2	TSLP	TSLP	NNP
cord-296585-yfh5d4io	195	3	(	(	-LRB-
cord-296585-yfh5d4io	195	4	116	116	CD
cord-296585-yfh5d4io	195	5	,	,	,
cord-296585-yfh5d4io	195	6	117	117	CD
cord-296585-yfh5d4io	195	7	)	)	-RRB-
cord-296585-yfh5d4io	195	8	,	,	,
cord-296585-yfh5d4io	195	9	and	and	CC
cord-296585-yfh5d4io	195	10	are	be	VBP
cord-296585-yfh5d4io	195	11	further	further	RB
cord-296585-yfh5d4io	195	12	stimulated	stimulate	VBN
cord-296585-yfh5d4io	195	13	in	in	IN
cord-296585-yfh5d4io	195	14	response	response	NN
cord-296585-yfh5d4io	195	15	to	to	IN
cord-296585-yfh5d4io	195	16	cell	cell	NN
cord-296585-yfh5d4io	195	17	damage	damage	NN
cord-296585-yfh5d4io	195	18	.	.	.
cord-296585-yfh5d4io	196	1	The	the	DT
cord-296585-yfh5d4io	196	2	accumulation	accumulation	NN
cord-296585-yfh5d4io	196	3	of	of	IN
cord-296585-yfh5d4io	196	4	B	b	NN
cord-296585-yfh5d4io	196	5	lymphocytes	lymphocyte	NNS
cord-296585-yfh5d4io	196	6	in	in	IN
cord-296585-yfh5d4io	196	7	the	the	DT
cord-296585-yfh5d4io	196	8	peripheral	peripheral	JJ
cord-296585-yfh5d4io	196	9	airway	airway	NN
cord-296585-yfh5d4io	196	10	and	and	CC
cord-296585-yfh5d4io	196	11	within	within	IN
cord-296585-yfh5d4io	196	12	lymphoid	lymphoid	JJ
cord-296585-yfh5d4io	196	13	follicles	follicle	NNS
cord-296585-yfh5d4io	196	14	is	be	VBZ
cord-296585-yfh5d4io	196	15	associated	associate	VBN
cord-296585-yfh5d4io	196	16	with	with	IN
cord-296585-yfh5d4io	196	17	airway	airway	NN
cord-296585-yfh5d4io	196	18	autoimmunity	autoimmunity	NN
cord-296585-yfh5d4io	196	19	in	in	IN
cord-296585-yfh5d4io	196	20	the	the	DT
cord-296585-yfh5d4io	196	21	progression	progression	NN
cord-296585-yfh5d4io	196	22	of	of	IN
cord-296585-yfh5d4io	196	23	COPD	COPD	NNP
cord-296585-yfh5d4io	196	24	(	(	-LRB-
cord-296585-yfh5d4io	196	25	118	118	CD
cord-296585-yfh5d4io	196	26	)	)	-RRB-
cord-296585-yfh5d4io	196	27	.	.	.
cord-296585-yfh5d4io	197	1	Airway	airway	JJ
cord-296585-yfh5d4io	197	2	tissue	tissue	NN
cord-296585-yfh5d4io	197	3	damage	damage	NN
cord-296585-yfh5d4io	197	4	in	in	IN
cord-296585-yfh5d4io	197	5	conjunction	conjunction	NN
cord-296585-yfh5d4io	197	6	with	with	IN
cord-296585-yfh5d4io	197	7	impaired	impaired	JJ
cord-296585-yfh5d4io	197	8	T	t	NN
cord-296585-yfh5d4io	197	9	-	-	HYPH
cord-296585-yfh5d4io	197	10	regulatory	regulatory	JJ
cord-296585-yfh5d4io	197	11	cells	cell	NNS
cord-296585-yfh5d4io	197	12	(	(	-LRB-
cord-296585-yfh5d4io	197	13	Tregs	Tregs	NNP
cord-296585-yfh5d4io	197	14	)	)	-RRB-
cord-296585-yfh5d4io	197	15	,	,	,
cord-296585-yfh5d4io	197	16	both	both	DT
cord-296585-yfh5d4io	197	17	related	relate	VBN
cord-296585-yfh5d4io	197	18	by	by	IN
cord-296585-yfh5d4io	197	19	cigarette	cigarette	NN
cord-296585-yfh5d4io	197	20	smoke	smoke	NN
cord-296585-yfh5d4io	197	21	,	,	,
cord-296585-yfh5d4io	197	22	contributes	contribute	VBZ
cord-296585-yfh5d4io	197	23	to	to	IN
cord-296585-yfh5d4io	197	24	the	the	DT
cord-296585-yfh5d4io	197	25	formation	formation	NN
cord-296585-yfh5d4io	197	26	of	of	IN
cord-296585-yfh5d4io	197	27	autoantibodies	autoantibody	NNS
cord-296585-yfh5d4io	197	28	against	against	IN
cord-296585-yfh5d4io	197	29	airway	airway	NN
cord-296585-yfh5d4io	197	30	components	component	NNS
cord-296585-yfh5d4io	197	31	.	.	.
cord-296585-yfh5d4io	198	1	Autoantibodies	Autoantibodies	NNP
cord-296585-yfh5d4io	198	2	against	against	IN
cord-296585-yfh5d4io	198	3	elastin	elastin	NN
cord-296585-yfh5d4io	198	4	,	,	,
cord-296585-yfh5d4io	198	5	epithelial	epithelial	JJ
cord-296585-yfh5d4io	198	6	,	,	,
cord-296585-yfh5d4io	198	7	endothelial	endothelial	JJ
cord-296585-yfh5d4io	198	8	,	,	,
cord-296585-yfh5d4io	198	9	carbonylated	carbonylate	VBN
cord-296585-yfh5d4io	198	10	,	,	,
cord-296585-yfh5d4io	198	11	and	and	CC
cord-296585-yfh5d4io	198	12	citrullinated	citrullinate	VBN
cord-296585-yfh5d4io	198	13	proteins	protein	NNS
cord-296585-yfh5d4io	198	14	are	be	VBP
cord-296585-yfh5d4io	198	15	found	find	VBN
cord-296585-yfh5d4io	198	16	in	in	IN
cord-296585-yfh5d4io	198	17	the	the	DT
cord-296585-yfh5d4io	198	18	circulation	circulation	NN
cord-296585-yfh5d4io	198	19	of	of	IN
cord-296585-yfh5d4io	198	20	COPD	COPD	NNP
cord-296585-yfh5d4io	198	21	patients	patient	NNS
cord-296585-yfh5d4io	198	22	(	(	-LRB-
cord-296585-yfh5d4io	198	23	119	119	CD
cord-296585-yfh5d4io	198	24	)	)	-RRB-
cord-296585-yfh5d4io	198	25	(	(	-LRB-
cord-296585-yfh5d4io	198	26	120	120	CD
cord-296585-yfh5d4io	198	27	)	)	-RRB-
cord-296585-yfh5d4io	199	1	(	(	-LRB-
cord-296585-yfh5d4io	199	2	121	121	CD
cord-296585-yfh5d4io	199	3	)	)	-RRB-
cord-296585-yfh5d4io	199	4	(	(	-LRB-
cord-296585-yfh5d4io	199	5	122	122	CD
cord-296585-yfh5d4io	199	6	)	)	-RRB-
cord-296585-yfh5d4io	199	7	(	(	-LRB-
cord-296585-yfh5d4io	199	8	123	123	CD
cord-296585-yfh5d4io	199	9	)	)	-RRB-
cord-296585-yfh5d4io	199	10	(	(	-LRB-
cord-296585-yfh5d4io	199	11	124	124	CD
cord-296585-yfh5d4io	199	12	)	)	-RRB-
cord-296585-yfh5d4io	199	13	.	.	.
cord-296585-yfh5d4io	200	1	The	the	DT
cord-296585-yfh5d4io	200	2	generation	generation	NN
cord-296585-yfh5d4io	200	3	of	of	IN
cord-296585-yfh5d4io	200	4	autoantibodies	autoantibody	NNS
cord-296585-yfh5d4io	200	5	might	may	MD
cord-296585-yfh5d4io	200	6	activate	activate	VB
cord-296585-yfh5d4io	200	7	plasma	plasma	NN
cord-296585-yfh5d4io	200	8	exudate	exudate	NN
cord-296585-yfh5d4io	200	9	-	-	HYPH
cord-296585-yfh5d4io	200	10	derived	derive	VBN
cord-296585-yfh5d4io	200	11	complement	complement	NN
cord-296585-yfh5d4io	200	12	components	component	NNS
cord-296585-yfh5d4io	200	13	resulting	result	VBG
cord-296585-yfh5d4io	200	14	in	in	IN
cord-296585-yfh5d4io	200	15	a	a	DT
cord-296585-yfh5d4io	200	16	chronic	chronic	JJ
cord-296585-yfh5d4io	200	17	inflammation	inflammation	NN
cord-296585-yfh5d4io	200	18	,	,	,
cord-296585-yfh5d4io	200	19	and	and	CC
cord-296585-yfh5d4io	200	20	consequently	consequently	RB
cord-296585-yfh5d4io	200	21	damage	damage	NN
cord-296585-yfh5d4io	200	22	of	of	IN
cord-296585-yfh5d4io	200	23	the	the	DT
cord-296585-yfh5d4io	200	24	airways	airways	NNPS
cord-296585-yfh5d4io	200	25	with	with	IN
cord-296585-yfh5d4io	200	26	emphysema	emphysema	NN
cord-296585-yfh5d4io	200	27	progression	progression	NN
cord-296585-yfh5d4io	200	28	(	(	-LRB-
cord-296585-yfh5d4io	200	29	124	124	CD
cord-296585-yfh5d4io	200	30	)	)	-RRB-
cord-296585-yfh5d4io	200	31	(	(	-LRB-
cord-296585-yfh5d4io	200	32	125	125	CD
cord-296585-yfh5d4io	200	33	)	)	-RRB-
cord-296585-yfh5d4io	200	34	(	(	-LRB-
cord-296585-yfh5d4io	200	35	126	126	CD
cord-296585-yfh5d4io	200	36	)	)	-RRB-
cord-296585-yfh5d4io	200	37	(	(	-LRB-
cord-296585-yfh5d4io	200	38	127	127	CD
cord-296585-yfh5d4io	200	39	)	)	-RRB-
cord-296585-yfh5d4io	200	40	.	.	.
cord-296585-yfh5d4io	201	1	From	from	IN
cord-296585-yfh5d4io	201	2	a	a	DT
cord-296585-yfh5d4io	201	3	physiological	physiological	JJ
cord-296585-yfh5d4io	201	4	point	point	NN
cord-296585-yfh5d4io	201	5	of	of	IN
cord-296585-yfh5d4io	201	6	view	view	NN
cord-296585-yfh5d4io	201	7	,	,	,
cord-296585-yfh5d4io	201	8	a	a	DT
cord-296585-yfh5d4io	201	9	modulated	modulate	VBN
cord-296585-yfh5d4io	201	10	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	201	11	process	process	NN
cord-296585-yfh5d4io	201	12	is	be	VBZ
cord-296585-yfh5d4io	201	13	important	important	JJ
cord-296585-yfh5d4io	201	14	for	for	IN
cord-296585-yfh5d4io	201	15	a	a	DT
cord-296585-yfh5d4io	201	16	protective	protective	JJ
cord-296585-yfh5d4io	201	17	and	and	CC
cord-296585-yfh5d4io	201	18	optimal	optimal	JJ
cord-296585-yfh5d4io	201	19	immune	immune	JJ
cord-296585-yfh5d4io	201	20	response	response	NN
cord-296585-yfh5d4io	201	21	.	.	.
cord-296585-yfh5d4io	202	1	However	however	RB
cord-296585-yfh5d4io	202	2	,	,	,
cord-296585-yfh5d4io	202	3	the	the	DT
cord-296585-yfh5d4io	202	4	prolonged	prolong	VBN
cord-296585-yfh5d4io	202	5	airway	airway	NN
cord-296585-yfh5d4io	202	6	inflammation	inflammation	NN
cord-296585-yfh5d4io	202	7	in	in	IN
cord-296585-yfh5d4io	202	8	COPD	COPD	NNP
cord-296585-yfh5d4io	202	9	as	as	IN
cord-296585-yfh5d4io	202	10	a	a	DT
cord-296585-yfh5d4io	202	11	results	result	NNS
cord-296585-yfh5d4io	202	12	of	of	IN
cord-296585-yfh5d4io	202	13	impaired	impaired	JJ
cord-296585-yfh5d4io	202	14	homeostasis	homeostasis	NN
cord-296585-yfh5d4io	202	15	leads	lead	VBZ
cord-296585-yfh5d4io	202	16	to	to	IN
cord-296585-yfh5d4io	202	17	serious	serious	JJ
cord-296585-yfh5d4io	202	18	side	side	NN
cord-296585-yfh5d4io	202	19	effects	effect	NNS
cord-296585-yfh5d4io	202	20	since	since	IN
cord-296585-yfh5d4io	202	21	it	-PRON-	PRP
cord-296585-yfh5d4io	202	22	amplifies	amplify	VBZ
cord-296585-yfh5d4io	202	23	the	the	DT
cord-296585-yfh5d4io	202	24	tissue	tissue	NN
cord-296585-yfh5d4io	202	25	damage	damage	NN
cord-296585-yfh5d4io	202	26	and	and	CC
cord-296585-yfh5d4io	202	27	impairs	impair	VBZ
cord-296585-yfh5d4io	202	28	the	the	DT
cord-296585-yfh5d4io	202	29	local	local	JJ
cord-296585-yfh5d4io	202	30	immune	immune	JJ
cord-296585-yfh5d4io	202	31	defenses	defense	NNS
cord-296585-yfh5d4io	202	32	.	.	.
cord-296585-yfh5d4io	203	1	The	the	DT
cord-296585-yfh5d4io	203	2	abrogated	abrogated	JJ
cord-296585-yfh5d4io	203	3	local	local	JJ
cord-296585-yfh5d4io	203	4	immune	immune	JJ
cord-296585-yfh5d4io	203	5	system	system	NN
cord-296585-yfh5d4io	203	6	may	may	MD
cord-296585-yfh5d4io	203	7	make	make	VB
cord-296585-yfh5d4io	203	8	the	the	DT
cord-296585-yfh5d4io	203	9	airways	airway	NNS
cord-296585-yfh5d4io	203	10	of	of	IN
cord-296585-yfh5d4io	203	11	COPD	COPD	NNP
cord-296585-yfh5d4io	203	12	patients	patient	NNS
cord-296585-yfh5d4io	203	13	susceptible	susceptible	JJ
cord-296585-yfh5d4io	203	14	for	for	IN
cord-296585-yfh5d4io	203	15	opportunistic	opportunistic	JJ
cord-296585-yfh5d4io	203	16	or	or	CC
cord-296585-yfh5d4io	203	17	recurrent	recurrent	JJ
cord-296585-yfh5d4io	203	18	infections	infection	NNS
cord-296585-yfh5d4io	203	19	by	by	IN
cord-296585-yfh5d4io	203	20	viruses	virus	NNS
cord-296585-yfh5d4io	203	21	and	and	CC
cord-296585-yfh5d4io	203	22	bacteria	bacteria	NNS
cord-296585-yfh5d4io	203	23	that	that	IN
cord-296585-yfh5d4io	203	24	in	in	IN
cord-296585-yfh5d4io	203	25	turn	turn	NN
cord-296585-yfh5d4io	203	26	might	may	MD
cord-296585-yfh5d4io	203	27	exacerbate	exacerbate	VB
cord-296585-yfh5d4io	203	28	the	the	DT
cord-296585-yfh5d4io	203	29	disease	disease	NN
cord-296585-yfh5d4io	203	30	.	.	.
cord-296585-yfh5d4io	204	1	Acute	acute	JJ
cord-296585-yfh5d4io	204	2	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	204	3	of	of	IN
cord-296585-yfh5d4io	204	4	COPD	COPD	NNP
cord-296585-yfh5d4io	204	5	(	(	-LRB-
cord-296585-yfh5d4io	204	6	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	204	7	)	)	-RRB-
cord-296585-yfh5d4io	204	8	are	be	VBP
cord-296585-yfh5d4io	204	9	episodes	episode	NNS
cord-296585-yfh5d4io	204	10	of	of	IN
cord-296585-yfh5d4io	204	11	acute	acute	JJ
cord-296585-yfh5d4io	204	12	symptom	symptom	NN
cord-296585-yfh5d4io	204	13	worsening	worsen	VBG
cord-296585-yfh5d4io	204	14	that	that	WDT
cord-296585-yfh5d4io	204	15	usually	usually	RB
cord-296585-yfh5d4io	204	16	are	be	VBP
cord-296585-yfh5d4io	204	17	associated	associate	VBN
cord-296585-yfh5d4io	204	18	with	with	IN
cord-296585-yfh5d4io	204	19	both	both	DT
cord-296585-yfh5d4io	204	20	respiratory	respiratory	JJ
cord-296585-yfh5d4io	204	21	(	(	-LRB-
cord-296585-yfh5d4io	204	22	increased	increase	VBN
cord-296585-yfh5d4io	204	23	airway	airway	NN
cord-296585-yfh5d4io	204	24	inflammation	inflammation	NN
cord-296585-yfh5d4io	204	25	)	)	-RRB-
cord-296585-yfh5d4io	204	26	and	and	CC
cord-296585-yfh5d4io	204	27	non	non	JJ
cord-296585-yfh5d4io	204	28	-	-	JJ
cord-296585-yfh5d4io	204	29	respiratory	respiratory	JJ
cord-296585-yfh5d4io	204	30	(	(	-LRB-
cord-296585-yfh5d4io	204	31	system	system	NN
cord-296585-yfh5d4io	204	32	inflammation	inflammation	NN
cord-296585-yfh5d4io	204	33	/	/	SYM
cord-296585-yfh5d4io	204	34	co	co	NNS
cord-296585-yfh5d4io	204	35	-	-	NNS
cord-296585-yfh5d4io	204	36	morbidities	morbidity	NNS
cord-296585-yfh5d4io	204	37	)	)	-RRB-
cord-296585-yfh5d4io	204	38	effects	effect	NNS
cord-296585-yfh5d4io	204	39	(	(	-LRB-
cord-296585-yfh5d4io	204	40	128	128	CD
cord-296585-yfh5d4io	204	41	)	)	-RRB-
cord-296585-yfh5d4io	204	42	(	(	-LRB-
cord-296585-yfh5d4io	204	43	129	129	CD
cord-296585-yfh5d4io	204	44	)	)	-RRB-
cord-296585-yfh5d4io	204	45	(	(	-LRB-
cord-296585-yfh5d4io	204	46	130	130	CD
cord-296585-yfh5d4io	204	47	)	)	-RRB-
cord-296585-yfh5d4io	204	48	.	.	.
cord-296585-yfh5d4io	205	1	The	the	DT
cord-296585-yfh5d4io	205	2	typical	typical	JJ
cord-296585-yfh5d4io	205	3	symptoms	symptom	NNS
cord-296585-yfh5d4io	205	4	of	of	IN
cord-296585-yfh5d4io	205	5	an	an	DT
cord-296585-yfh5d4io	205	6	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	205	7	include	include	VBP
cord-296585-yfh5d4io	205	8	increased	increase	VBN
cord-296585-yfh5d4io	205	9	production	production	NN
cord-296585-yfh5d4io	205	10	of	of	IN
cord-296585-yfh5d4io	205	11	purulent	purulent	JJ
cord-296585-yfh5d4io	205	12	sputum	sputum	NN
cord-296585-yfh5d4io	205	13	,	,	,
cord-296585-yfh5d4io	205	14	dyspnea	dyspnea	NN
cord-296585-yfh5d4io	205	15	,	,	,
cord-296585-yfh5d4io	205	16	cough	cough	NN
cord-296585-yfh5d4io	205	17	,	,	,
cord-296585-yfh5d4io	205	18	wheezing	wheeze	VBG
cord-296585-yfh5d4io	205	19	,	,	,
cord-296585-yfh5d4io	205	20	and	and	CC
cord-296585-yfh5d4io	205	21	symptoms	symptom	NNS
cord-296585-yfh5d4io	205	22	of	of	IN
cord-296585-yfh5d4io	205	23	a	a	DT
cord-296585-yfh5d4io	205	24	cold	cold	NN
cord-296585-yfh5d4io	205	25	that	that	WDT
cord-296585-yfh5d4io	205	26	may	may	MD
cord-296585-yfh5d4io	205	27	last	last	VB
cord-296585-yfh5d4io	205	28	from	from	IN
cord-296585-yfh5d4io	205	29	7	7	CD
cord-296585-yfh5d4io	205	30	days	day	NNS
cord-296585-yfh5d4io	205	31	up	up	IN
cord-296585-yfh5d4io	205	32	to	to	TO
cord-296585-yfh5d4io	205	33	12	12	CD
cord-296585-yfh5d4io	205	34	weeks	week	NNS
cord-296585-yfh5d4io	205	35	(	(	-LRB-
cord-296585-yfh5d4io	205	36	15	15	CD
cord-296585-yfh5d4io	205	37	,	,	,
cord-296585-yfh5d4io	205	38	130	130	CD
cord-296585-yfh5d4io	205	39	,	,	,
cord-296585-yfh5d4io	205	40	131	131	CD
cord-296585-yfh5d4io	205	41	)	)	-RRB-
cord-296585-yfh5d4io	205	42	.	.	.
cord-296585-yfh5d4io	206	1	It	-PRON-	PRP
cord-296585-yfh5d4io	206	2	commonly	commonly	RB
cord-296585-yfh5d4io	206	3	occurs	occur	VBZ
cord-296585-yfh5d4io	206	4	in	in	IN
cord-296585-yfh5d4io	206	5	patients	patient	NNS
cord-296585-yfh5d4io	206	6	with	with	IN
cord-296585-yfh5d4io	206	7	advanced	advanced	JJ
cord-296585-yfh5d4io	206	8	COPD	COPD	NNP
cord-296585-yfh5d4io	206	9	and	and	CC
cord-296585-yfh5d4io	206	10	results	result	NNS
cord-296585-yfh5d4io	206	11	in	in	IN
cord-296585-yfh5d4io	206	12	additional	additional	JJ
cord-296585-yfh5d4io	206	13	therapy	therapy	NN
cord-296585-yfh5d4io	206	14	based	base	VBN
cord-296585-yfh5d4io	206	15	on	on	IN
cord-296585-yfh5d4io	206	16	the	the	DT
cord-296585-yfh5d4io	206	17	level	level	NN
cord-296585-yfh5d4io	206	18	of	of	IN
cord-296585-yfh5d4io	206	19	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	206	20	.	.	.
cord-296585-yfh5d4io	207	1	Exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	207	2	are	be	VBP
cord-296585-yfh5d4io	207	3	classified	classify	VBN
cord-296585-yfh5d4io	207	4	in	in	IN
cord-296585-yfh5d4io	207	5	three	three	CD
cord-296585-yfh5d4io	207	6	levels	level	NNS
cord-296585-yfh5d4io	207	7	according	accord	VBG
cord-296585-yfh5d4io	207	8	to	to	IN
cord-296585-yfh5d4io	207	9	GOLD	gold	NN
cord-296585-yfh5d4io	207	10	.	.	.
cord-296585-yfh5d4io	208	1	There	there	EX
cord-296585-yfh5d4io	208	2	is	be	VBZ
cord-296585-yfh5d4io	208	3	the	the	DT
cord-296585-yfh5d4io	208	4	mild	mild	JJ
cord-296585-yfh5d4io	208	5	disease	disease	NN
cord-296585-yfh5d4io	208	6	that	that	WDT
cord-296585-yfh5d4io	208	7	can	can	MD
cord-296585-yfh5d4io	208	8	be	be	VB
cord-296585-yfh5d4io	208	9	treated	treat	VBN
cord-296585-yfh5d4io	208	10	with	with	IN
cord-296585-yfh5d4io	208	11	short	short	JJ
cord-296585-yfh5d4io	208	12	acting	acting	NN
cord-296585-yfh5d4io	208	13	bronchodilators	bronchodilator	NNS
cord-296585-yfh5d4io	208	14	(	(	-LRB-
cord-296585-yfh5d4io	208	15	SAB	SAB	NNP
cord-296585-yfh5d4io	208	16	)	)	-RRB-
cord-296585-yfh5d4io	208	17	;	;	:
cord-296585-yfh5d4io	208	18	moderate	moderate	JJ
cord-296585-yfh5d4io	208	19	disease	disease	NN
cord-296585-yfh5d4io	208	20	with	with	IN
cord-296585-yfh5d4io	208	21	SAB	SAB	NNP
cord-296585-yfh5d4io	208	22	combined	combine	VBN
cord-296585-yfh5d4io	208	23	with	with	IN
cord-296585-yfh5d4io	208	24	antibiotics	antibiotic	NNS
cord-296585-yfh5d4io	208	25	and/	and/	CD
cord-296585-yfh5d4io	208	26	or	or	CC
cord-296585-yfh5d4io	208	27	oral	oral	JJ
cord-296585-yfh5d4io	208	28	corticosteroids	corticosteroid	NNS
cord-296585-yfh5d4io	208	29	;	;	:
cord-296585-yfh5d4io	208	30	and	and	CC
cord-296585-yfh5d4io	208	31	finally	finally	RB
cord-296585-yfh5d4io	208	32	severe	severe	JJ
cord-296585-yfh5d4io	208	33	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	208	34	with	with	IN
cord-296585-yfh5d4io	208	35	acute	acute	JJ
cord-296585-yfh5d4io	208	36	respiratory	respiratory	JJ
cord-296585-yfh5d4io	208	37	failure	failure	NN
cord-296585-yfh5d4io	208	38	which	which	WDT
cord-296585-yfh5d4io	208	39	requires	require	VBZ
cord-296585-yfh5d4io	208	40	emergency	emergency	NN
cord-296585-yfh5d4io	208	41	room	room	NN
cord-296585-yfh5d4io	208	42	visit	visit	NN
cord-296585-yfh5d4io	208	43	and	and	CC
cord-296585-yfh5d4io	208	44	eventually	eventually	RB
cord-296585-yfh5d4io	208	45	hospitalization	hospitalization	NN
cord-296585-yfh5d4io	208	46	(	(	-LRB-
cord-296585-yfh5d4io	208	47	15	15	CD
cord-296585-yfh5d4io	208	48	,	,	,
cord-296585-yfh5d4io	208	49	130	130	CD
cord-296585-yfh5d4io	208	50	)	)	-RRB-
cord-296585-yfh5d4io	208	51	.	.	.
cord-296585-yfh5d4io	209	1	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	209	2	is	be	VBZ
cord-296585-yfh5d4io	209	3	a	a	DT
cord-296585-yfh5d4io	209	4	complex	complex	NN
cord-296585-yfh5d4io	209	5	yet	yet	CC
cord-296585-yfh5d4io	209	6	multifactorial	multifactorial	JJ
cord-296585-yfh5d4io	209	7	consequence	consequence	NN
cord-296585-yfh5d4io	209	8	of	of	IN
cord-296585-yfh5d4io	209	9	COPD	COPD	NNP
cord-296585-yfh5d4io	209	10	.	.	.
cord-296585-yfh5d4io	210	1	Most	Most	JJS
cord-296585-yfh5d4io	210	2	of	of	IN
cord-296585-yfh5d4io	210	3	the	the	DT
cord-296585-yfh5d4io	210	4	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	210	5	could	could	MD
cord-296585-yfh5d4io	210	6	be	be	VB
cord-296585-yfh5d4io	210	7	triggered	trigger	VBN
cord-296585-yfh5d4io	210	8	by	by	IN
cord-296585-yfh5d4io	210	9	infectious	infectious	JJ
cord-296585-yfh5d4io	210	10	(	(	-LRB-
cord-296585-yfh5d4io	210	11	up	up	IN
cord-296585-yfh5d4io	210	12	to	to	TO
cord-296585-yfh5d4io	210	13	80	80	CD
cord-296585-yfh5d4io	210	14	%	%	NN
cord-296585-yfh5d4io	210	15	)	)	-RRB-
cord-296585-yfh5d4io	210	16	or	or	CC
cord-296585-yfh5d4io	210	17	non	non	JJ
cord-296585-yfh5d4io	210	18	-	-	JJ
cord-296585-yfh5d4io	210	19	infectious	infectious	JJ
cord-296585-yfh5d4io	210	20	agents	agent	NNS
cord-296585-yfh5d4io	210	21	(	(	-LRB-
cord-296585-yfh5d4io	210	22	∼10	∼10	NNP
cord-296585-yfh5d4io	210	23	%	%	NN
cord-296585-yfh5d4io	210	24	)	)	-RRB-
cord-296585-yfh5d4io	211	1	(	(	-LRB-
cord-296585-yfh5d4io	211	2	AECOPD	aecopd	NN
cord-296585-yfh5d4io	211	3	with	with	IN
cord-296585-yfh5d4io	211	4	known	know	VBN
cord-296585-yfh5d4io	211	5	etiology	etiology	NN
cord-296585-yfh5d4io	211	6	)	)	-RRB-
cord-296585-yfh5d4io	211	7	,	,	,
cord-296585-yfh5d4io	211	8	whereas	whereas	IN
cord-296585-yfh5d4io	211	9	up	up	IN
cord-296585-yfh5d4io	211	10	to	to	TO
cord-296585-yfh5d4io	211	11	30	30	CD
cord-296585-yfh5d4io	211	12	%	%	NN
cord-296585-yfh5d4io	211	13	of	of	IN
cord-296585-yfh5d4io	211	14	cases	case	NNS
cord-296585-yfh5d4io	211	15	are	be	VBP
cord-296585-yfh5d4io	211	16	of	of	IN
cord-296585-yfh5d4io	211	17	unknown	unknown	JJ
cord-296585-yfh5d4io	211	18	etiology	etiology	NN
cord-296585-yfh5d4io	211	19	(	(	-LRB-
cord-296585-yfh5d4io	211	20	132	132	CD
cord-296585-yfh5d4io	211	21	,	,	,
cord-296585-yfh5d4io	211	22	133	133	CD
cord-296585-yfh5d4io	211	23	)	)	-RRB-
cord-296585-yfh5d4io	211	24	.	.	.
cord-296585-yfh5d4io	212	1	Respiratory	respiratory	JJ
cord-296585-yfh5d4io	212	2	tract	tract	NN
cord-296585-yfh5d4io	212	3	infections	infection	NNS
cord-296585-yfh5d4io	212	4	are	be	VBP
cord-296585-yfh5d4io	212	5	the	the	DT
cord-296585-yfh5d4io	212	6	major	major	JJ
cord-296585-yfh5d4io	212	7	causes	cause	NNS
cord-296585-yfh5d4io	212	8	for	for	IN
cord-296585-yfh5d4io	212	9	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	212	10	with	with	IN
cord-296585-yfh5d4io	212	11	known	know	VBN
cord-296585-yfh5d4io	212	12	etiology	etiology	NN
cord-296585-yfh5d4io	212	13	and	and	CC
cord-296585-yfh5d4io	212	14	are	be	VBP
cord-296585-yfh5d4io	212	15	mainly	mainly	RB
cord-296585-yfh5d4io	212	16	attributed	attribute	VBN
cord-296585-yfh5d4io	212	17	to	to	IN
cord-296585-yfh5d4io	212	18	infections	infection	NNS
cord-296585-yfh5d4io	212	19	by	by	IN
cord-296585-yfh5d4io	212	20	viruses	virus	NNS
cord-296585-yfh5d4io	212	21	,	,	,
cord-296585-yfh5d4io	212	22	bacteria	bacteria	NNS
cord-296585-yfh5d4io	212	23	,	,	,
cord-296585-yfh5d4io	212	24	and	and	CC
cord-296585-yfh5d4io	212	25	atypical	atypical	JJ
cord-296585-yfh5d4io	212	26	bacteria	bacteria	NNS
cord-296585-yfh5d4io	212	27	(	(	-LRB-
cord-296585-yfh5d4io	212	28	not	not	RB
cord-296585-yfh5d4io	212	29	detected	detect	VBN
cord-296585-yfh5d4io	212	30	with	with	IN
cord-296585-yfh5d4io	212	31	conventional	conventional	JJ
cord-296585-yfh5d4io	212	32	Gram	gram	NN
cord-296585-yfh5d4io	212	33	-	-	HYPH
cord-296585-yfh5d4io	212	34	staining	staining	NN
cord-296585-yfh5d4io	212	35	)	)	-RRB-
cord-296585-yfh5d4io	212	36	(	(	-LRB-
cord-296585-yfh5d4io	212	37	11	11	CD
cord-296585-yfh5d4io	212	38	,	,	,
cord-296585-yfh5d4io	212	39	134	134	CD
cord-296585-yfh5d4io	212	40	,	,	,
cord-296585-yfh5d4io	212	41	135	135	CD
cord-296585-yfh5d4io	212	42	)	)	-RRB-
cord-296585-yfh5d4io	212	43	.	.	.
cord-296585-yfh5d4io	213	1	Non	non	JJ
cord-296585-yfh5d4io	213	2	-	-	JJ
cord-296585-yfh5d4io	213	3	infectious	infectious	JJ
cord-296585-yfh5d4io	213	4	causes	cause	NNS
cord-296585-yfh5d4io	213	5	of	of	IN
cord-296585-yfh5d4io	213	6	AECOPD	AECOPD	NNS
cord-296585-yfh5d4io	213	7	include	include	VBP
cord-296585-yfh5d4io	213	8	air	air	NN
cord-296585-yfh5d4io	213	9	pollution	pollution	NN
cord-296585-yfh5d4io	213	10	,	,	,
cord-296585-yfh5d4io	213	11	environmental	environmental	JJ
cord-296585-yfh5d4io	213	12	factors	factor	NNS
cord-296585-yfh5d4io	213	13	,	,	,
cord-296585-yfh5d4io	213	14	meteorological	meteorological	JJ
cord-296585-yfh5d4io	213	15	effects	effect	NNS
cord-296585-yfh5d4io	213	16	,	,	,
cord-296585-yfh5d4io	213	17	and	and	CC
cord-296585-yfh5d4io	213	18	comorbidities	comorbiditie	NNS
cord-296585-yfh5d4io	213	19	of	of	IN
cord-296585-yfh5d4io	213	20	the	the	DT
cord-296585-yfh5d4io	213	21	patients	patient	NNS
cord-296585-yfh5d4io	213	22	,	,	,
cord-296585-yfh5d4io	213	23	all	all	DT
cord-296585-yfh5d4io	213	24	of	of	IN
cord-296585-yfh5d4io	213	25	which	which	WDT
cord-296585-yfh5d4io	213	26	are	be	VBP
cord-296585-yfh5d4io	213	27	partially	partially	RB
cord-296585-yfh5d4io	213	28	contributing	contribute	VBG
cord-296585-yfh5d4io	213	29	to	to	IN
cord-296585-yfh5d4io	213	30	COPD	COPD	NNP
cord-296585-yfh5d4io	213	31	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	213	32	(	(	-LRB-
cord-296585-yfh5d4io	213	33	133	133	CD
cord-296585-yfh5d4io	213	34	,	,	,
cord-296585-yfh5d4io	213	35	135	135	CD
cord-296585-yfh5d4io	213	36	,	,	,
cord-296585-yfh5d4io	213	37	136	136	CD
cord-296585-yfh5d4io	213	38	)	)	-RRB-
cord-296585-yfh5d4io	213	39	.	.	.
cord-296585-yfh5d4io	214	1	Respiratory	respiratory	JJ
cord-296585-yfh5d4io	214	2	viral	viral	JJ
cord-296585-yfh5d4io	214	3	infections	infection	NNS
cord-296585-yfh5d4io	214	4	are	be	VBP
cord-296585-yfh5d4io	214	5	often	often	RB
cord-296585-yfh5d4io	214	6	the	the	DT
cord-296585-yfh5d4io	214	7	primary	primary	JJ
cord-296585-yfh5d4io	214	8	cause	cause	NN
cord-296585-yfh5d4io	214	9	in	in	IN
cord-296585-yfh5d4io	214	10	the	the	DT
cord-296585-yfh5d4io	214	11	infection	infection	NN
cord-296585-yfh5d4io	214	12	-	-	HYPH
cord-296585-yfh5d4io	214	13	dependent	dependent	JJ
cord-296585-yfh5d4io	214	14	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	214	15	,	,	,
cord-296585-yfh5d4io	214	16	and	and	CC
cord-296585-yfh5d4io	214	17	virus	virus	NN
cord-296585-yfh5d4io	214	18	was	be	VBD
cord-296585-yfh5d4io	214	19	identified	identify	VBN
cord-296585-yfh5d4io	214	20	as	as	IN
cord-296585-yfh5d4io	214	21	single	single	JJ
cord-296585-yfh5d4io	214	22	or	or	CC
cord-296585-yfh5d4io	214	23	multiple	multiple	JJ
cord-296585-yfh5d4io	214	24	infecting	infect	VBG
cord-296585-yfh5d4io	214	25	strains	strain	NNS
cord-296585-yfh5d4io	214	26	from	from	IN
cord-296585-yfh5d4io	214	27	up	up	IN
cord-296585-yfh5d4io	214	28	to	to	TO
cord-296585-yfh5d4io	214	29	64	64	CD
cord-296585-yfh5d4io	214	30	%	%	NN
cord-296585-yfh5d4io	214	31	of	of	IN
cord-296585-yfh5d4io	214	32	COPD	COPD	NNP
cord-296585-yfh5d4io	214	33	patients	patient	NNS
cord-296585-yfh5d4io	214	34	with	with	IN
cord-296585-yfh5d4io	214	35	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	214	36	recorded	record	VBN
cord-296585-yfh5d4io	214	37	between	between	IN
cord-296585-yfh5d4io	214	38	years	year	NNS
cord-296585-yfh5d4io	214	39	2001	2001	CD
cord-296585-yfh5d4io	214	40	-	-	SYM
cord-296585-yfh5d4io	214	41	2017	2017	CD
cord-296585-yfh5d4io	214	42	(	(	-LRB-
cord-296585-yfh5d4io	214	43	137	137	CD
cord-296585-yfh5d4io	214	44	)	)	-RRB-
cord-296585-yfh5d4io	214	45	(	(	-LRB-
cord-296585-yfh5d4io	214	46	138	138	CD
cord-296585-yfh5d4io	214	47	)	)	-RRB-
cord-296585-yfh5d4io	215	1	(	(	-LRB-
cord-296585-yfh5d4io	215	2	139	139	CD
cord-296585-yfh5d4io	215	3	)	)	-RRB-
cord-296585-yfh5d4io	216	1	(	(	-LRB-
cord-296585-yfh5d4io	216	2	140	140	CD
cord-296585-yfh5d4io	216	3	)	)	-RRB-
cord-296585-yfh5d4io	216	4	(	(	-LRB-
cord-296585-yfh5d4io	216	5	141	141	CD
cord-296585-yfh5d4io	216	6	)	)	-RRB-
cord-296585-yfh5d4io	216	7	(	(	-LRB-
cord-296585-yfh5d4io	216	8	142	142	CD
cord-296585-yfh5d4io	216	9	)	)	-RRB-
cord-296585-yfh5d4io	217	1	(	(	-LRB-
cord-296585-yfh5d4io	217	2	143	143	CD
cord-296585-yfh5d4io	217	3	)	)	-RRB-
cord-296585-yfh5d4io	217	4	(	(	-LRB-
cord-296585-yfh5d4io	217	5	144	144	CD
cord-296585-yfh5d4io	217	6	)	)	-RRB-
cord-296585-yfh5d4io	217	7	(	(	-LRB-
cord-296585-yfh5d4io	217	8	145	145	CD
cord-296585-yfh5d4io	217	9	)	)	-RRB-
cord-296585-yfh5d4io	217	10	.	.	.
cord-296585-yfh5d4io	218	1	The	the	DT
cord-296585-yfh5d4io	218	2	most	most	RBS
cord-296585-yfh5d4io	218	3	common	common	JJ
cord-296585-yfh5d4io	218	4	infecting	infect	VBG
cord-296585-yfh5d4io	218	5	viruses	virus	NNS
cord-296585-yfh5d4io	218	6	are	be	VBP
cord-296585-yfh5d4io	218	7	,	,	,
cord-296585-yfh5d4io	218	8	by	by	IN
cord-296585-yfh5d4io	218	9	far	far	RB
cord-296585-yfh5d4io	218	10	,	,	,
cord-296585-yfh5d4io	218	11	human	human	JJ
cord-296585-yfh5d4io	218	12	rhinovirus	rhinovirus	NN
cord-296585-yfh5d4io	218	13	,	,	,
cord-296585-yfh5d4io	218	14	influenza	influenza	NN
cord-296585-yfh5d4io	218	15	virus	virus	NN
cord-296585-yfh5d4io	218	16	A	A	NNP
cord-296585-yfh5d4io	218	17	,	,	,
cord-296585-yfh5d4io	218	18	and	and	CC
cord-296585-yfh5d4io	218	19	respiratory	respiratory	JJ
cord-296585-yfh5d4io	218	20	syncytial	syncytial	JJ
cord-296585-yfh5d4io	218	21	virus	virus	NN
cord-296585-yfh5d4io	218	22	,	,	,
cord-296585-yfh5d4io	218	23	whereas	whereas	IN
cord-296585-yfh5d4io	218	24	parainfluenza	parainfluenza	NNP
cord-296585-yfh5d4io	218	25	virus	virus	NN
cord-296585-yfh5d4io	218	26	,	,	,
cord-296585-yfh5d4io	218	27	coronavirus	coronavirus	NN
cord-296585-yfh5d4io	218	28	,	,	,
cord-296585-yfh5d4io	218	29	echovirus	echovirus	NNP
cord-296585-yfh5d4io	218	30	,	,	,
cord-296585-yfh5d4io	218	31	human	human	JJ
cord-296585-yfh5d4io	218	32	metapneumovirus	metapneumovirus	NNP
cord-296585-yfh5d4io	218	33	,	,	,
cord-296585-yfh5d4io	218	34	and	and	CC
cord-296585-yfh5d4io	218	35	adenovirus	adenovirus	NN
cord-296585-yfh5d4io	218	36	are	be	VBP
cord-296585-yfh5d4io	218	37	considerably	considerably	RB
cord-296585-yfh5d4io	218	38	rare	rare	JJ
cord-296585-yfh5d4io	218	39	.	.	.
cord-296585-yfh5d4io	219	1	Bacterial	bacterial	JJ
cord-296585-yfh5d4io	219	2	infections	infection	NNS
cord-296585-yfh5d4io	219	3	contribute	contribute	VBP
cord-296585-yfh5d4io	219	4	to	to	IN
cord-296585-yfh5d4io	219	5	an	an	DT
cord-296585-yfh5d4io	219	6	average	average	NN
cord-296585-yfh5d4io	219	7	of	of	IN
cord-296585-yfh5d4io	219	8	50	50	CD
cord-296585-yfh5d4io	219	9	%	%	NN
cord-296585-yfh5d4io	219	10	of	of	IN
cord-296585-yfh5d4io	219	11	infective	infective	JJ
cord-296585-yfh5d4io	219	12	acute	acute	JJ
cord-296585-yfh5d4io	219	13	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	219	14	with	with	IN
cord-296585-yfh5d4io	219	15	a	a	DT
cord-296585-yfh5d4io	219	16	prevalence	prevalence	NN
cord-296585-yfh5d4io	219	17	being	be	VBG
cord-296585-yfh5d4io	219	18	reported	report	VBN
cord-296585-yfh5d4io	219	19	ranging	range	VBG
cord-296585-yfh5d4io	219	20	from	from	IN
cord-296585-yfh5d4io	219	21	26	26	CD
cord-296585-yfh5d4io	219	22	to	to	TO
cord-296585-yfh5d4io	219	23	81	81	CD
cord-296585-yfh5d4io	219	24	%	%	NN
cord-296585-yfh5d4io	219	25	(	(	-LRB-
cord-296585-yfh5d4io	219	26	132	132	CD
cord-296585-yfh5d4io	219	27	,	,	,
cord-296585-yfh5d4io	219	28	135	135	CD
cord-296585-yfh5d4io	219	29	,	,	,
cord-296585-yfh5d4io	219	30	(	(	-LRB-
cord-296585-yfh5d4io	219	31	146	146	CD
cord-296585-yfh5d4io	219	32	)	)	-RRB-
cord-296585-yfh5d4io	219	33	(	(	-LRB-
cord-296585-yfh5d4io	219	34	147	147	CD
cord-296585-yfh5d4io	219	35	)	)	-RRB-
cord-296585-yfh5d4io	219	36	(	(	-LRB-
cord-296585-yfh5d4io	219	37	148	148	CD
cord-296585-yfh5d4io	219	38	)	)	-RRB-
cord-296585-yfh5d4io	219	39	.	.	.
cord-296585-yfh5d4io	220	1	The	the	DT
cord-296585-yfh5d4io	220	2	most	most	RBS
cord-296585-yfh5d4io	220	3	commonly	commonly	RB
cord-296585-yfh5d4io	220	4	pathogenic	pathogenic	JJ
cord-296585-yfh5d4io	220	5	bacterial	bacterial	JJ
cord-296585-yfh5d4io	220	6	species	specie	NNS
cord-296585-yfh5d4io	220	7	isolated	isolate	VBN
cord-296585-yfh5d4io	220	8	from	from	IN
cord-296585-yfh5d4io	220	9	the	the	DT
cord-296585-yfh5d4io	220	10	lower	low	JJR
cord-296585-yfh5d4io	220	11	airway	airway	NN
cord-296585-yfh5d4io	220	12	of	of	IN
cord-296585-yfh5d4io	220	13	COPD	COPD	NNP
cord-296585-yfh5d4io	220	14	patients	patient	NNS
cord-296585-yfh5d4io	220	15	during	during	IN
cord-296585-yfh5d4io	220	16	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	220	17	are	be	VBP
cord-296585-yfh5d4io	220	18	NTHi	NTHi	NNS
cord-296585-yfh5d4io	220	19	,	,	,
cord-296585-yfh5d4io	220	20	Moraxella	Moraxella	NNP
cord-296585-yfh5d4io	220	21	catarrhalis	catarrhalis	NNP
cord-296585-yfh5d4io	220	22	,	,	,
cord-296585-yfh5d4io	220	23	Streptococcus	streptococcus	NN
cord-296585-yfh5d4io	220	24	pneumoniae	pneumoniae	NN
cord-296585-yfh5d4io	220	25	,	,	,
cord-296585-yfh5d4io	220	26	Staphylococcus	Staphylococcus	NNP
cord-296585-yfh5d4io	220	27	aureus	aureus	NN
cord-296585-yfh5d4io	220	28	,	,	,
cord-296585-yfh5d4io	220	29	Pseudomonas	Pseudomonas	NNP
cord-296585-yfh5d4io	220	30	aeruginosa	aeruginosa	NN
cord-296585-yfh5d4io	220	31	,	,	,
cord-296585-yfh5d4io	220	32	and	and	CC
cord-296585-yfh5d4io	220	33	Klebsiella	Klebsiella	NNP
cord-296585-yfh5d4io	220	34	pneumoniae	pneumoniae	NNS
cord-296585-yfh5d4io	220	35	(	(	-LRB-
cord-296585-yfh5d4io	220	36	11	11	CD
cord-296585-yfh5d4io	220	37	,	,	,
cord-296585-yfh5d4io	220	38	129	129	CD
cord-296585-yfh5d4io	220	39	,	,	,
cord-296585-yfh5d4io	220	40	133	133	CD
cord-296585-yfh5d4io	220	41	,	,	,
cord-296585-yfh5d4io	220	42	136	136	CD
cord-296585-yfh5d4io	220	43	,	,	,
cord-296585-yfh5d4io	220	44	(	(	-LRB-
cord-296585-yfh5d4io	220	45	149	149	CD
cord-296585-yfh5d4io	220	46	)	)	-RRB-
cord-296585-yfh5d4io	220	47	(	(	-LRB-
cord-296585-yfh5d4io	220	48	150	150	CD
cord-296585-yfh5d4io	220	49	)	)	-RRB-
cord-296585-yfh5d4io	220	50	(	(	-LRB-
cord-296585-yfh5d4io	220	51	151	151	CD
cord-296585-yfh5d4io	220	52	)	)	-RRB-
cord-296585-yfh5d4io	220	53	(	(	-LRB-
cord-296585-yfh5d4io	220	54	152	152	CD
cord-296585-yfh5d4io	220	55	)	)	-RRB-
cord-296585-yfh5d4io	220	56	.	.	.
cord-296585-yfh5d4io	221	1	It	-PRON-	PRP
cord-296585-yfh5d4io	221	2	has	have	VBZ
cord-296585-yfh5d4io	221	3	been	be	VBN
cord-296585-yfh5d4io	221	4	suggested	suggest	VBN
cord-296585-yfh5d4io	221	5	that	that	IN
cord-296585-yfh5d4io	221	6	infection	infection	NN
cord-296585-yfh5d4io	221	7	with	with	IN
cord-296585-yfh5d4io	221	8	new	new	JJ
cord-296585-yfh5d4io	221	9	strains	strain	NNS
cord-296585-yfh5d4io	221	10	of	of	IN
cord-296585-yfh5d4io	221	11	the	the	DT
cord-296585-yfh5d4io	221	12	infecting	infect	VBG
cord-296585-yfh5d4io	221	13	species	specie	NNS
cord-296585-yfh5d4io	221	14	,	,	,
cord-296585-yfh5d4io	221	15	rather	rather	RB
cord-296585-yfh5d4io	221	16	than	than	IN
cord-296585-yfh5d4io	221	17	a	a	DT
cord-296585-yfh5d4io	221	18	new	new	JJ
cord-296585-yfh5d4io	221	19	species	specie	NNS
cord-296585-yfh5d4io	221	20	,	,	,
cord-296585-yfh5d4io	221	21	is	be	VBZ
cord-296585-yfh5d4io	221	22	highly	highly	RB
cord-296585-yfh5d4io	221	23	associated	associate	VBN
cord-296585-yfh5d4io	221	24	with	with	IN
cord-296585-yfh5d4io	221	25	an	an	DT
cord-296585-yfh5d4io	221	26	increased	increase	VBN
cord-296585-yfh5d4io	221	27	risk	risk	NN
cord-296585-yfh5d4io	221	28	of	of	IN
cord-296585-yfh5d4io	221	29	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	221	30	(	(	-LRB-
cord-296585-yfh5d4io	221	31	11	11	CD
cord-296585-yfh5d4io	221	32	,	,	,
cord-296585-yfh5d4io	221	33	153	153	CD
cord-296585-yfh5d4io	221	34	,	,	,
cord-296585-yfh5d4io	221	35	154	154	CD
cord-296585-yfh5d4io	221	36	)	)	-RRB-
cord-296585-yfh5d4io	221	37	.	.	.
cord-296585-yfh5d4io	222	1	Atypical	atypical	JJ
cord-296585-yfh5d4io	222	2	bacteria	bacteria	NNS
cord-296585-yfh5d4io	222	3	that	that	WDT
cord-296585-yfh5d4io	222	4	cause	cause	VBP
cord-296585-yfh5d4io	222	5	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	222	6	are	be	VBP
cord-296585-yfh5d4io	222	7	Chlamydia	Chlamydia	NNP
cord-296585-yfh5d4io	222	8	spp	spp	NNS
cord-296585-yfh5d4io	222	9	.	.	.
cord-296585-yfh5d4io	223	1	,	,	,
cord-296585-yfh5d4io	223	2	Legionella	Legionella	NNP
cord-296585-yfh5d4io	223	3	pneumophilia	pneumophilia	NNP
cord-296585-yfh5d4io	223	4	,	,	,
cord-296585-yfh5d4io	223	5	and	and	CC
cord-296585-yfh5d4io	223	6	Mycoplasma	Mycoplasma	NNP
cord-296585-yfh5d4io	223	7	spp	spp	NNS
cord-296585-yfh5d4io	223	8	.	.	.
cord-296585-yfh5d4io	224	1	In	in	IN
cord-296585-yfh5d4io	224	2	contrast	contrast	NN
cord-296585-yfh5d4io	224	3	to	to	IN
cord-296585-yfh5d4io	224	4	viral	viral	JJ
cord-296585-yfh5d4io	224	5	infections	infection	NNS
cord-296585-yfh5d4io	224	6	that	that	WDT
cord-296585-yfh5d4io	224	7	are	be	VBP
cord-296585-yfh5d4io	224	8	diagnosed	diagnose	VBN
cord-296585-yfh5d4io	224	9	in	in	IN
cord-296585-yfh5d4io	224	10	5	5	CD
cord-296585-yfh5d4io	224	11	-	-	SYM
cord-296585-yfh5d4io	224	12	45	45	CD
cord-296585-yfh5d4io	224	13	%	%	NN
cord-296585-yfh5d4io	224	14	of	of	IN
cord-296585-yfh5d4io	224	15	COPD	COPD	NNP
cord-296585-yfh5d4io	224	16	patients	patient	NNS
cord-296585-yfh5d4io	224	17	with	with	IN
cord-296585-yfh5d4io	224	18	stable	stable	JJ
cord-296585-yfh5d4io	224	19	disease	disease	NN
cord-296585-yfh5d4io	224	20	and	and	CC
cord-296585-yfh5d4io	224	21	increase	increase	VB
cord-296585-yfh5d4io	224	22	to	to	IN
cord-296585-yfh5d4io	224	23	39.3	39.3	CD
cord-296585-yfh5d4io	224	24	-	-	SYM
cord-296585-yfh5d4io	224	25	64	64	CD
cord-296585-yfh5d4io	224	26	%	%	NN
cord-296585-yfh5d4io	224	27	during	during	IN
cord-296585-yfh5d4io	224	28	COPD	COPD	NNP
cord-296585-yfh5d4io	224	29	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	224	30	,	,	,
cord-296585-yfh5d4io	224	31	bacterial	bacterial	JJ
cord-296585-yfh5d4io	224	32	colonization	colonization	NN
cord-296585-yfh5d4io	224	33	in	in	IN
cord-296585-yfh5d4io	224	34	the	the	DT
cord-296585-yfh5d4io	224	35	airways	airway	NNS
cord-296585-yfh5d4io	224	36	are	be	VBP
cord-296585-yfh5d4io	224	37	more	more	RBR
cord-296585-yfh5d4io	224	38	common	common	JJ
cord-296585-yfh5d4io	224	39	with	with	IN
cord-296585-yfh5d4io	224	40	the	the	DT
cord-296585-yfh5d4io	224	41	same	same	JJ
cord-296585-yfh5d4io	224	42	species	specie	NNS
cord-296585-yfh5d4io	224	43	during	during	IN
cord-296585-yfh5d4io	224	44	both	both	DT
cord-296585-yfh5d4io	224	45	stable	stable	JJ
cord-296585-yfh5d4io	224	46	disease	disease	NN
cord-296585-yfh5d4io	224	47	(	(	-LRB-
cord-296585-yfh5d4io	224	48	25	25	CD
cord-296585-yfh5d4io	224	49	-	-	SYM
cord-296585-yfh5d4io	224	50	86	86	CD
cord-296585-yfh5d4io	224	51	%	%	NN
cord-296585-yfh5d4io	224	52	)	)	-RRB-
cord-296585-yfh5d4io	224	53	and	and	CC
cord-296585-yfh5d4io	224	54	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	224	55	(	(	-LRB-
cord-296585-yfh5d4io	224	56	58.8	58.8	CD
cord-296585-yfh5d4io	224	57	-	-	SYM
cord-296585-yfh5d4io	224	58	81	81	CD
cord-296585-yfh5d4io	224	59	%	%	NN
cord-296585-yfh5d4io	224	60	)	)	-RRB-
cord-296585-yfh5d4io	224	61	(	(	-LRB-
cord-296585-yfh5d4io	224	62	11	11	CD
cord-296585-yfh5d4io	224	63	,	,	,
cord-296585-yfh5d4io	224	64	132	132	CD
cord-296585-yfh5d4io	224	65	,	,	,
cord-296585-yfh5d4io	224	66	136	136	CD
cord-296585-yfh5d4io	224	67	,	,	,
cord-296585-yfh5d4io	224	68	137	137	CD
cord-296585-yfh5d4io	224	69	,	,	,
cord-296585-yfh5d4io	224	70	142	142	CD
cord-296585-yfh5d4io	224	71	,	,	,
cord-296585-yfh5d4io	224	72	(	(	-LRB-
cord-296585-yfh5d4io	224	73	155	155	CD
cord-296585-yfh5d4io	224	74	)	)	-RRB-
cord-296585-yfh5d4io	224	75	(	(	-LRB-
cord-296585-yfh5d4io	224	76	156	156	CD
cord-296585-yfh5d4io	224	77	)	)	-RRB-
cord-296585-yfh5d4io	224	78	(	(	-LRB-
cord-296585-yfh5d4io	224	79	157	157	CD
cord-296585-yfh5d4io	224	80	)	)	-RRB-
cord-296585-yfh5d4io	224	81	(	(	-LRB-
cord-296585-yfh5d4io	224	82	158	158	CD
cord-296585-yfh5d4io	224	83	)	)	-RRB-
cord-296585-yfh5d4io	224	84	.	.	.
cord-296585-yfh5d4io	225	1	Hence	hence	RB
cord-296585-yfh5d4io	225	2	the	the	DT
cord-296585-yfh5d4io	225	3	precise	precise	JJ
cord-296585-yfh5d4io	225	4	or	or	CC
cord-296585-yfh5d4io	225	5	direct	direct	JJ
cord-296585-yfh5d4io	225	6	role	role	NN
cord-296585-yfh5d4io	225	7	of	of	IN
cord-296585-yfh5d4io	225	8	bacterial	bacterial	JJ
cord-296585-yfh5d4io	225	9	infection	infection	NN
cord-296585-yfh5d4io	225	10	as	as	IN
cord-296585-yfh5d4io	225	11	the	the	DT
cord-296585-yfh5d4io	225	12	primary	primary	JJ
cord-296585-yfh5d4io	225	13	cause	cause	NN
cord-296585-yfh5d4io	225	14	in	in	IN
cord-296585-yfh5d4io	225	15	triggering	trigger	VBG
cord-296585-yfh5d4io	225	16	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	225	17	remains	remain	VBZ
cord-296585-yfh5d4io	225	18	controversial	controversial	JJ
cord-296585-yfh5d4io	225	19	although	although	IN
cord-296585-yfh5d4io	225	20	a	a	DT
cord-296585-yfh5d4io	225	21	significantly	significantly	RB
cord-296585-yfh5d4io	225	22	increased	increase	VBN
cord-296585-yfh5d4io	225	23	bacterial	bacterial	JJ
cord-296585-yfh5d4io	225	24	load	load	NN
cord-296585-yfh5d4io	225	25	is	be	VBZ
cord-296585-yfh5d4io	225	26	observed	observe	VBN
cord-296585-yfh5d4io	225	27	during	during	IN
cord-296585-yfh5d4io	225	28	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	225	29	in	in	IN
cord-296585-yfh5d4io	225	30	several	several	JJ
cord-296585-yfh5d4io	225	31	patients	patient	NNS
cord-296585-yfh5d4io	225	32	.	.	.
cord-296585-yfh5d4io	226	1	This	this	DT
cord-296585-yfh5d4io	226	2	further	further	RB
cord-296585-yfh5d4io	226	3	suggests	suggest	VBZ
cord-296585-yfh5d4io	226	4	that	that	IN
cord-296585-yfh5d4io	226	5	bacteria	bacteria	NNS
cord-296585-yfh5d4io	226	6	might	may	MD
cord-296585-yfh5d4io	226	7	be	be	VB
cord-296585-yfh5d4io	226	8	more	more	RBR
cord-296585-yfh5d4io	226	9	involved	involved	JJ
cord-296585-yfh5d4io	226	10	as	as	IN
cord-296585-yfh5d4io	226	11	secondary	secondary	JJ
cord-296585-yfh5d4io	226	12	invaders	invader	NNS
cord-296585-yfh5d4io	226	13	after	after	IN
cord-296585-yfh5d4io	226	14	an	an	DT
cord-296585-yfh5d4io	226	15	initial	initial	JJ
cord-296585-yfh5d4io	226	16	viral	viral	JJ
cord-296585-yfh5d4io	226	17	infection	infection	NN
cord-296585-yfh5d4io	226	18	.	.	.
cord-296585-yfh5d4io	227	1	Viral	viral	JJ
cord-296585-yfh5d4io	227	2	infections	infection	NNS
cord-296585-yfh5d4io	227	3	have	have	VBP
cord-296585-yfh5d4io	227	4	been	be	VBN
cord-296585-yfh5d4io	227	5	reported	report	VBN
cord-296585-yfh5d4io	227	6	to	to	TO
cord-296585-yfh5d4io	227	7	cause	cause	VB
cord-296585-yfh5d4io	227	8	several	several	JJ
cord-296585-yfh5d4io	227	9	physiological	physiological	JJ
cord-296585-yfh5d4io	227	10	changes	change	NNS
cord-296585-yfh5d4io	227	11	in	in	IN
cord-296585-yfh5d4io	227	12	the	the	DT
cord-296585-yfh5d4io	227	13	lung	lung	NN
cord-296585-yfh5d4io	227	14	that	that	WDT
cord-296585-yfh5d4io	227	15	in	in	IN
cord-296585-yfh5d4io	227	16	turn	turn	NN
cord-296585-yfh5d4io	227	17	facilitates	facilitate	VBZ
cord-296585-yfh5d4io	227	18	secondary	secondary	JJ
cord-296585-yfh5d4io	227	19	bacterial	bacterial	JJ
cord-296585-yfh5d4io	227	20	invasion	invasion	NN
cord-296585-yfh5d4io	227	21	.	.	.
cord-296585-yfh5d4io	228	1	The	the	DT
cord-296585-yfh5d4io	228	2	mechanism	mechanism	NN
cord-296585-yfh5d4io	228	3	of	of	IN
cord-296585-yfh5d4io	228	4	bacterial	bacterial	JJ
cord-296585-yfh5d4io	228	5	superinfection	superinfection	NN
cord-296585-yfh5d4io	228	6	has	have	VBZ
cord-296585-yfh5d4io	228	7	been	be	VBN
cord-296585-yfh5d4io	228	8	described	describe	VBN
cord-296585-yfh5d4io	228	9	for	for	IN
cord-296585-yfh5d4io	228	10	H.	H.	NNP
cord-296585-yfh5d4io	228	11	influenzae	influenzae	NN
cord-296585-yfh5d4io	228	12	,	,	,
cord-296585-yfh5d4io	228	13	S.	S.	NNP
cord-296585-yfh5d4io	228	14	pneumoniae	pneumoniae	NN
cord-296585-yfh5d4io	228	15	,	,	,
cord-296585-yfh5d4io	228	16	S.	S.	NNP
cord-296585-yfh5d4io	228	17	aureus	aureus	NN
cord-296585-yfh5d4io	228	18	,	,	,
cord-296585-yfh5d4io	228	19	and	and	CC
cord-296585-yfh5d4io	228	20	many	many	JJ
cord-296585-yfh5d4io	228	21	other	other	JJ
cord-296585-yfh5d4io	228	22	airway	airway	NN
cord-296585-yfh5d4io	228	23	pathogens	pathogen	NNS
cord-296585-yfh5d4io	228	24	(	(	-LRB-
cord-296585-yfh5d4io	228	25	159	159	CD
cord-296585-yfh5d4io	228	26	)	)	-RRB-
cord-296585-yfh5d4io	228	27	(	(	-LRB-
cord-296585-yfh5d4io	228	28	160	160	CD
cord-296585-yfh5d4io	228	29	)	)	-RRB-
cord-296585-yfh5d4io	228	30	(	(	-LRB-
cord-296585-yfh5d4io	228	31	161	161	CD
cord-296585-yfh5d4io	228	32	)	)	-RRB-
cord-296585-yfh5d4io	228	33	.	.	.
cord-296585-yfh5d4io	229	1	Firstly	firstly	RB
cord-296585-yfh5d4io	229	2	,	,	,
cord-296585-yfh5d4io	229	3	viral	viral	JJ
cord-296585-yfh5d4io	229	4	infections	infection	NNS
cord-296585-yfh5d4io	229	5	destroy	destroy	VBP
cord-296585-yfh5d4io	229	6	the	the	DT
cord-296585-yfh5d4io	229	7	tight	tight	JJ
cord-296585-yfh5d4io	229	8	junctions	junction	NNS
cord-296585-yfh5d4io	229	9	of	of	IN
cord-296585-yfh5d4io	229	10	the	the	DT
cord-296585-yfh5d4io	229	11	airway	airway	JJ
cord-296585-yfh5d4io	229	12	epithelial	epithelial	JJ
cord-296585-yfh5d4io	229	13	barrier	barrier	NN
cord-296585-yfh5d4io	229	14	while	while	IN
cord-296585-yfh5d4io	229	15	inducing	induce	VBG
cord-296585-yfh5d4io	229	16	epithelium	epithelium	NN
cord-296585-yfh5d4io	229	17	apoptosis	apoptosis	NN
cord-296585-yfh5d4io	229	18	.	.	.
cord-296585-yfh5d4io	230	1	This	this	DT
cord-296585-yfh5d4io	230	2	results	result	VBZ
cord-296585-yfh5d4io	230	3	in	in	IN
cord-296585-yfh5d4io	230	4	the	the	DT
cord-296585-yfh5d4io	230	5	onset	onset	NN
cord-296585-yfh5d4io	230	6	of	of	IN
cord-296585-yfh5d4io	230	7	airway	airway	NN
cord-296585-yfh5d4io	230	8	epithelium	epithelium	NN
cord-296585-yfh5d4io	230	9	lining	lining	NN
cord-296585-yfh5d4io	230	10	repair	repair	NN
cord-296585-yfh5d4io	230	11	whereby	whereby	WRB
cord-296585-yfh5d4io	230	12	the	the	DT
cord-296585-yfh5d4io	230	13	sloughed	slough	VBN
cord-296585-yfh5d4io	230	14	off	off	RP
cord-296585-yfh5d4io	230	15	dead	dead	JJ
cord-296585-yfh5d4io	230	16	cells	cell	NNS
cord-296585-yfh5d4io	230	17	would	would	MD
cord-296585-yfh5d4io	230	18	become	become	VB
cord-296585-yfh5d4io	230	19	a	a	DT
cord-296585-yfh5d4io	230	20	rich	rich	JJ
cord-296585-yfh5d4io	230	21	nutrient	nutrient	NN
cord-296585-yfh5d4io	230	22	source	source	NN
cord-296585-yfh5d4io	230	23	for	for	IN
cord-296585-yfh5d4io	230	24	growth	growth	NN
cord-296585-yfh5d4io	230	25	of	of	IN
cord-296585-yfh5d4io	230	26	infecting	infect	VBG
cord-296585-yfh5d4io	230	27	bacteria	bacteria	NNS
cord-296585-yfh5d4io	230	28	.	.	.
cord-296585-yfh5d4io	231	1	The	the	DT
cord-296585-yfh5d4io	231	2	damaged	damage	VBN
cord-296585-yfh5d4io	231	3	epithelium	epithelium	NN
cord-296585-yfh5d4io	231	4	lining	lining	NN
cord-296585-yfh5d4io	231	5	also	also	RB
cord-296585-yfh5d4io	231	6	enables	enable	VBZ
cord-296585-yfh5d4io	231	7	bacterial	bacterial	JJ
cord-296585-yfh5d4io	231	8	adherence	adherence	NN
cord-296585-yfh5d4io	231	9	to	to	IN
cord-296585-yfh5d4io	231	10	the	the	DT
cord-296585-yfh5d4io	231	11	exposed	expose	VBN
cord-296585-yfh5d4io	231	12	basement	basement	NN
cord-296585-yfh5d4io	231	13	membrane	membrane	NN
cord-296585-yfh5d4io	231	14	and	and	CC
cord-296585-yfh5d4io	231	15	ECM	ECM	NNP
cord-296585-yfh5d4io	231	16	.	.	.
cord-296585-yfh5d4io	232	1	Secondly	secondly	RB
cord-296585-yfh5d4io	232	2	,	,	,
cord-296585-yfh5d4io	232	3	the	the	DT
cord-296585-yfh5d4io	232	4	demolished	demolish	VBN
cord-296585-yfh5d4io	232	5	ciliated	ciliated	JJ
cord-296585-yfh5d4io	232	6	clearance	clearance	NN
cord-296585-yfh5d4io	232	7	as	as	IN
cord-296585-yfh5d4io	232	8	a	a	DT
cord-296585-yfh5d4io	232	9	result	result	NN
cord-296585-yfh5d4io	232	10	of	of	IN
cord-296585-yfh5d4io	232	11	the	the	DT
cord-296585-yfh5d4io	232	12	virus	virus	NN
cord-296585-yfh5d4io	232	13	-	-	HYPH
cord-296585-yfh5d4io	232	14	damaged	damage	VBN
cord-296585-yfh5d4io	232	15	airway	airway	NN
cord-296585-yfh5d4io	232	16	epithelium	epithelium	NN
cord-296585-yfh5d4io	232	17	lining	line	VBG
cord-296585-yfh5d4io	232	18	further	further	RB
cord-296585-yfh5d4io	232	19	promotes	promote	VBZ
cord-296585-yfh5d4io	232	20	bacterial	bacterial	JJ
cord-296585-yfh5d4io	232	21	colonization	colonization	NN
cord-296585-yfh5d4io	232	22	and	and	CC
cord-296585-yfh5d4io	232	23	subsequent	subsequent	JJ
cord-296585-yfh5d4io	232	24	epithelial	epithelial	JJ
cord-296585-yfh5d4io	232	25	transmigration	transmigration	NN
cord-296585-yfh5d4io	232	26	into	into	IN
cord-296585-yfh5d4io	232	27	deeper	deep	JJR
cord-296585-yfh5d4io	232	28	tissues	tissue	NNS
cord-296585-yfh5d4io	232	29	(	(	-LRB-
cord-296585-yfh5d4io	232	30	162	162	CD
cord-296585-yfh5d4io	232	31	)	)	-RRB-
cord-296585-yfh5d4io	232	32	(	(	-LRB-
cord-296585-yfh5d4io	232	33	163	163	CD
cord-296585-yfh5d4io	232	34	)	)	-RRB-
cord-296585-yfh5d4io	232	35	(	(	-LRB-
cord-296585-yfh5d4io	232	36	164	164	CD
cord-296585-yfh5d4io	232	37	)	)	-RRB-
cord-296585-yfh5d4io	232	38	.	.	.
cord-296585-yfh5d4io	233	1	Lastly	lastly	RB
cord-296585-yfh5d4io	233	2	,	,	,
cord-296585-yfh5d4io	233	3	viral	viral	JJ
cord-296585-yfh5d4io	233	4	infections	infection	NNS
cord-296585-yfh5d4io	233	5	are	be	VBP
cord-296585-yfh5d4io	233	6	also	also	RB
cord-296585-yfh5d4io	233	7	detrimental	detrimental	JJ
cord-296585-yfh5d4io	233	8	to	to	IN
cord-296585-yfh5d4io	233	9	the	the	DT
cord-296585-yfh5d4io	233	10	airway	airway	NN
cord-296585-yfh5d4io	233	11	immune	immune	JJ
cord-296585-yfh5d4io	233	12	defense	defense	NN
cord-296585-yfh5d4io	233	13	by	by	IN
cord-296585-yfh5d4io	233	14	causing	cause	VBG
cord-296585-yfh5d4io	233	15	degradation	degradation	NN
cord-296585-yfh5d4io	233	16	of	of	IN
cord-296585-yfh5d4io	233	17	antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	233	18	peptides	peptide	NNS
cord-296585-yfh5d4io	233	19	(	(	-LRB-
cord-296585-yfh5d4io	233	20	AMP	AMP	NNP
cord-296585-yfh5d4io	233	21	)	)	-RRB-
cord-296585-yfh5d4io	233	22	,	,	,
cord-296585-yfh5d4io	233	23	and	and	CC
cord-296585-yfh5d4io	233	24	by	by	IN
cord-296585-yfh5d4io	233	25	triggering	trigger	VBG
cord-296585-yfh5d4io	233	26	IFN	IFN	NNP
cord-296585-yfh5d4io	233	27	-	-	HYPH
cord-296585-yfh5d4io	233	28	γ	γ	NN
cord-296585-yfh5d4io	233	29	secretion	secretion	NN
cord-296585-yfh5d4io	233	30	by	by	IN
cord-296585-yfh5d4io	233	31	immune	immune	JJ
cord-296585-yfh5d4io	233	32	cells	cell	NNS
cord-296585-yfh5d4io	233	33	.	.	.
cord-296585-yfh5d4io	234	1	This	this	DT
cord-296585-yfh5d4io	234	2	results	result	VBZ
cord-296585-yfh5d4io	234	3	in	in	IN
cord-296585-yfh5d4io	234	4	suppressed	suppress	VBN
cord-296585-yfh5d4io	234	5	macrophage	macrophage	NN
cord-296585-yfh5d4io	234	6	and	and	CC
cord-296585-yfh5d4io	234	7	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	234	8	responses	response	NNS
cord-296585-yfh5d4io	234	9	to	to	IN
cord-296585-yfh5d4io	234	10	infecting	infect	VBG
cord-296585-yfh5d4io	234	11	bacteria	bacteria	NNS
cord-296585-yfh5d4io	234	12	,	,	,
cord-296585-yfh5d4io	234	13	and	and	CC
cord-296585-yfh5d4io	234	14	thus	thus	RB
cord-296585-yfh5d4io	234	15	enables	enable	VBZ
cord-296585-yfh5d4io	234	16	bacterial	bacterial	JJ
cord-296585-yfh5d4io	234	17	evasion	evasion	NN
cord-296585-yfh5d4io	234	18	of	of	IN
cord-296585-yfh5d4io	234	19	the	the	DT
cord-296585-yfh5d4io	234	20	airway	airway	NN
cord-296585-yfh5d4io	234	21	immune	immune	JJ
cord-296585-yfh5d4io	234	22	defense	defense	NN
cord-296585-yfh5d4io	234	23	(	(	-LRB-
cord-296585-yfh5d4io	234	24	165	165	CD
cord-296585-yfh5d4io	234	25	)	)	-RRB-
cord-296585-yfh5d4io	234	26	(	(	-LRB-
cord-296585-yfh5d4io	234	27	166	166	CD
cord-296585-yfh5d4io	234	28	)	)	-RRB-
cord-296585-yfh5d4io	234	29	(	(	-LRB-
cord-296585-yfh5d4io	234	30	167	167	CD
cord-296585-yfh5d4io	234	31	)	)	-RRB-
cord-296585-yfh5d4io	234	32	(	(	-LRB-
cord-296585-yfh5d4io	234	33	168	168	CD
cord-296585-yfh5d4io	234	34	)	)	-RRB-
cord-296585-yfh5d4io	234	35	.	.	.
cord-296585-yfh5d4io	235	1	Nevertheless	nevertheless	RB
cord-296585-yfh5d4io	235	2	,	,	,
cord-296585-yfh5d4io	235	3	viral	viral	JJ
cord-296585-yfh5d4io	235	4	and	and	CC
cord-296585-yfh5d4io	235	5	bacterial	bacterial	JJ
cord-296585-yfh5d4io	235	6	coinfection	coinfection	NN
cord-296585-yfh5d4io	235	7	have	have	VBP
cord-296585-yfh5d4io	235	8	greater	great	JJR
cord-296585-yfh5d4io	235	9	impact	impact	NN
cord-296585-yfh5d4io	235	10	in	in	IN
cord-296585-yfh5d4io	235	11	the	the	DT
cord-296585-yfh5d4io	235	12	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	235	13	airway	airway	VB
cord-296585-yfh5d4io	235	14	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	235	15	responses	response	NNS
cord-296585-yfh5d4io	235	16	than	than	IN
cord-296585-yfh5d4io	235	17	bacteria	bacteria	NNS
cord-296585-yfh5d4io	235	18	or	or	CC
cord-296585-yfh5d4io	235	19	virus	virus	NN
cord-296585-yfh5d4io	235	20	infection	infection	NN
cord-296585-yfh5d4io	235	21	alone	alone	RB
cord-296585-yfh5d4io	235	22	(	(	-LRB-
cord-296585-yfh5d4io	235	23	168	168	CD
cord-296585-yfh5d4io	235	24	,	,	,
cord-296585-yfh5d4io	235	25	169	169	CD
cord-296585-yfh5d4io	235	26	)	)	-RRB-
cord-296585-yfh5d4io	235	27	.	.	.
cord-296585-yfh5d4io	236	1	This	this	DT
cord-296585-yfh5d4io	236	2	is	be	VBZ
cord-296585-yfh5d4io	236	3	in	in	IN
cord-296585-yfh5d4io	236	4	parallel	parallel	NN
cord-296585-yfh5d4io	236	5	with	with	IN
cord-296585-yfh5d4io	236	6	the	the	DT
cord-296585-yfh5d4io	236	7	co	co	NN
cord-296585-yfh5d4io	236	8	-	-	NN
cord-296585-yfh5d4io	236	9	isolation	isolation	NN
cord-296585-yfh5d4io	236	10	of	of	IN
cord-296585-yfh5d4io	236	11	both	both	DT
cord-296585-yfh5d4io	236	12	respiratory	respiratory	JJ
cord-296585-yfh5d4io	236	13	viruses	virus	NNS
cord-296585-yfh5d4io	236	14	and	and	CC
cord-296585-yfh5d4io	236	15	bacteria	bacteria	NNS
cord-296585-yfh5d4io	236	16	from	from	IN
cord-296585-yfh5d4io	236	17	6	6	CD
cord-296585-yfh5d4io	236	18	to	to	TO
cord-296585-yfh5d4io	236	19	30	30	CD
cord-296585-yfh5d4io	236	20	%	%	NN
cord-296585-yfh5d4io	236	21	of	of	IN
cord-296585-yfh5d4io	236	22	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	236	23	patients	patient	NNS
cord-296585-yfh5d4io	236	24	(	(	-LRB-
cord-296585-yfh5d4io	236	25	129	129	CD
cord-296585-yfh5d4io	236	26	,	,	,
cord-296585-yfh5d4io	236	27	133	133	CD
cord-296585-yfh5d4io	236	28	,	,	,
cord-296585-yfh5d4io	236	29	136	136	CD
cord-296585-yfh5d4io	236	30	,	,	,
cord-296585-yfh5d4io	236	31	(	(	-LRB-
cord-296585-yfh5d4io	236	32	170	170	CD
cord-296585-yfh5d4io	236	33	)	)	-RRB-
cord-296585-yfh5d4io	236	34	(	(	-LRB-
cord-296585-yfh5d4io	236	35	171	171	CD
cord-296585-yfh5d4io	236	36	)	)	-RRB-
cord-296585-yfh5d4io	236	37	(	(	-LRB-
cord-296585-yfh5d4io	236	38	172	172	CD
cord-296585-yfh5d4io	236	39	)	)	-RRB-
cord-296585-yfh5d4io	236	40	(	(	-LRB-
cord-296585-yfh5d4io	236	41	173	173	CD
cord-296585-yfh5d4io	236	42	)	)	-RRB-
cord-296585-yfh5d4io	236	43	(	(	-LRB-
cord-296585-yfh5d4io	236	44	174	174	CD
cord-296585-yfh5d4io	236	45	)	)	-RRB-
cord-296585-yfh5d4io	236	46	.	.	.
cord-296585-yfh5d4io	237	1	Infective	Infective	NNP
cord-296585-yfh5d4io	237	2	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	237	3	is	be	VBZ
cord-296585-yfh5d4io	237	4	also	also	RB
cord-296585-yfh5d4io	237	5	attributed	attribute	VBN
cord-296585-yfh5d4io	237	6	to	to	IN
cord-296585-yfh5d4io	237	7	impaired	impaired	JJ
cord-296585-yfh5d4io	237	8	functions	function	NNS
cord-296585-yfh5d4io	237	9	of	of	IN
cord-296585-yfh5d4io	237	10	AMP	amp	NN
cord-296585-yfh5d4io	237	11	,	,	,
cord-296585-yfh5d4io	237	12	macrophages	macrophage	NNS
cord-296585-yfh5d4io	237	13	,	,	,
cord-296585-yfh5d4io	237	14	and	and	CC
cord-296585-yfh5d4io	237	15	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	237	16	triggered	trigger	VBN
cord-296585-yfh5d4io	237	17	by	by	IN
cord-296585-yfh5d4io	237	18	inhaled	inhale	VBN
cord-296585-yfh5d4io	237	19	irritants	irritant	NNS
cord-296585-yfh5d4io	237	20	such	such	JJ
cord-296585-yfh5d4io	237	21	as	as	IN
cord-296585-yfh5d4io	237	22	tobacco	tobacco	NN
cord-296585-yfh5d4io	237	23	smoke	smoke	NN
cord-296585-yfh5d4io	237	24	.	.	.
cord-296585-yfh5d4io	238	1	Expression	expression	NN
cord-296585-yfh5d4io	238	2	of	of	IN
cord-296585-yfh5d4io	238	3	microbialinduced	microbialinduce	VBN
cord-296585-yfh5d4io	238	4	AMP	AMP	NNP
cord-296585-yfh5d4io	238	5	(	(	-LRB-
cord-296585-yfh5d4io	238	6	human	human	JJ
cord-296585-yfh5d4io	238	7	β	β	NNP
cord-296585-yfh5d4io	238	8	-	-	HYPH
cord-296585-yfh5d4io	238	9	defensin	defensin	NNP
cord-296585-yfh5d4io	238	10	2	2	CD
cord-296585-yfh5d4io	238	11	)	)	-RRB-
cord-296585-yfh5d4io	238	12	is	be	VBZ
cord-296585-yfh5d4io	238	13	suppressed	suppress	VBN
cord-296585-yfh5d4io	238	14	in	in	IN
cord-296585-yfh5d4io	238	15	airway	airway	NN
cord-296585-yfh5d4io	238	16	epithelial	epithelial	JJ
cord-296585-yfh5d4io	238	17	cells	cell	NNS
cord-296585-yfh5d4io	238	18	when	when	WRB
cord-296585-yfh5d4io	238	19	exposed	expose	VBN
cord-296585-yfh5d4io	238	20	to	to	IN
cord-296585-yfh5d4io	238	21	cigarette	cigarette	NN
cord-296585-yfh5d4io	238	22	smoke	smoke	NN
cord-296585-yfh5d4io	238	23	(	(	-LRB-
cord-296585-yfh5d4io	238	24	175	175	CD
cord-296585-yfh5d4io	238	25	,	,	,
cord-296585-yfh5d4io	238	26	176	176	CD
cord-296585-yfh5d4io	238	27	)	)	-RRB-
cord-296585-yfh5d4io	238	28	.	.	.
cord-296585-yfh5d4io	239	1	Both	both	DT
cord-296585-yfh5d4io	239	2	the	the	DT
cord-296585-yfh5d4io	239	3	alveolar	alveolar	NN
cord-296585-yfh5d4io	239	4	and	and	CC
cord-296585-yfh5d4io	239	5	monocyte	monocyte	NN
cord-296585-yfh5d4io	239	6	-	-	HYPH
cord-296585-yfh5d4io	239	7	derived	derive	VBN
cord-296585-yfh5d4io	239	8	macrophages	macrophage	NNS
cord-296585-yfh5d4io	239	9	in	in	IN
cord-296585-yfh5d4io	239	10	patients	patient	NNS
cord-296585-yfh5d4io	239	11	with	with	IN
cord-296585-yfh5d4io	239	12	COPD	COPD	NNP
cord-296585-yfh5d4io	239	13	are	be	VBP
cord-296585-yfh5d4io	239	14	defective	defective	JJ
cord-296585-yfh5d4io	239	15	in	in	IN
cord-296585-yfh5d4io	239	16	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	239	17	of	of	IN
cord-296585-yfh5d4io	239	18	bacteria	bacteria	NNS
cord-296585-yfh5d4io	239	19	such	such	JJ
cord-296585-yfh5d4io	239	20	as	as	IN
cord-296585-yfh5d4io	239	21	H.	H.	NNP
cord-296585-yfh5d4io	239	22	influenzae	influenzae	NN
cord-296585-yfh5d4io	239	23	and	and	CC
cord-296585-yfh5d4io	239	24	S.	S.	NNP
cord-296585-yfh5d4io	239	25	pneumoniae	pneumoniae	NN
cord-296585-yfh5d4io	239	26	(	(	-LRB-
cord-296585-yfh5d4io	239	27	177	177	CD
cord-296585-yfh5d4io	239	28	,	,	,
cord-296585-yfh5d4io	239	29	178	178	CD
cord-296585-yfh5d4io	239	30	)	)	-RRB-
cord-296585-yfh5d4io	239	31	,	,	,
cord-296585-yfh5d4io	239	32	and	and	CC
cord-296585-yfh5d4io	239	33	in	in	IN
cord-296585-yfh5d4io	239	34	efferocytosis	efferocytosis	NN
cord-296585-yfh5d4io	239	35	of	of	IN
cord-296585-yfh5d4io	239	36	apoptotic	apoptotic	JJ
cord-296585-yfh5d4io	239	37	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	239	38	and	and	CC
cord-296585-yfh5d4io	239	39	epithelial	epithelial	JJ
cord-296585-yfh5d4io	239	40	cells	cell	NNS
cord-296585-yfh5d4io	239	41	.	.	.
cord-296585-yfh5d4io	240	1	In	in	IN
cord-296585-yfh5d4io	240	2	addition	addition	NN
cord-296585-yfh5d4io	240	3	,	,	,
cord-296585-yfh5d4io	240	4	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	240	5	from	from	IN
cord-296585-yfh5d4io	240	6	COPD	COPD	NNP
cord-296585-yfh5d4io	240	7	patients	patient	NNS
cord-296585-yfh5d4io	240	8	are	be	VBP
cord-296585-yfh5d4io	240	9	aberrant	aberrant	JJ
cord-296585-yfh5d4io	240	10	in	in	IN
cord-296585-yfh5d4io	240	11	chemotactic	chemotactic	JJ
cord-296585-yfh5d4io	240	12	response	response	NN
cord-296585-yfh5d4io	240	13	with	with	IN
cord-296585-yfh5d4io	240	14	defective	defective	JJ
cord-296585-yfh5d4io	240	15	accuracy	accuracy	NN
cord-296585-yfh5d4io	240	16	(	(	-LRB-
cord-296585-yfh5d4io	240	17	179	179	CD
cord-296585-yfh5d4io	240	18	)	)	-RRB-
cord-296585-yfh5d4io	240	19	.	.	.
cord-296585-yfh5d4io	241	1	All	all	PDT
cord-296585-yfh5d4io	241	2	these	these	DT
cord-296585-yfh5d4io	241	3	factors	factor	NNS
cord-296585-yfh5d4io	241	4	contribute	contribute	VBP
cord-296585-yfh5d4io	241	5	to	to	IN
cord-296585-yfh5d4io	241	6	the	the	DT
cord-296585-yfh5d4io	241	7	failure	failure	NN
cord-296585-yfh5d4io	241	8	to	to	TO
cord-296585-yfh5d4io	241	9	resolve	resolve	VB
cord-296585-yfh5d4io	241	10	inflammation	inflammation	NN
cord-296585-yfh5d4io	241	11	in	in	IN
cord-296585-yfh5d4io	241	12	COPD	COPD	NNP
cord-296585-yfh5d4io	241	13	leading	lead	VBG
cord-296585-yfh5d4io	241	14	to	to	IN
cord-296585-yfh5d4io	241	15	facilitated	facilitate	VBN
cord-296585-yfh5d4io	241	16	chronic	chronic	JJ
cord-296585-yfh5d4io	241	17	microbial	microbial	JJ
cord-296585-yfh5d4io	241	18	colonization	colonization	NN
cord-296585-yfh5d4io	241	19	,	,	,
cord-296585-yfh5d4io	241	20	also	also	RB
cord-296585-yfh5d4io	241	21	during	during	IN
cord-296585-yfh5d4io	241	22	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	241	23	.	.	.
cord-296585-yfh5d4io	242	1	The	the	DT
cord-296585-yfh5d4io	242	2	low	low	JJ
cord-296585-yfh5d4io	242	3	number	number	NN
cord-296585-yfh5d4io	242	4	of	of	IN
cord-296585-yfh5d4io	242	5	cultivable	cultivable	JJ
cord-296585-yfh5d4io	242	6	bacteria	bacteria	NNS
cord-296585-yfh5d4io	242	7	found	find	VBN
cord-296585-yfh5d4io	242	8	in	in	IN
cord-296585-yfh5d4io	242	9	healthy	healthy	JJ
cord-296585-yfh5d4io	242	10	individuals	individual	NNS
cord-296585-yfh5d4io	242	11	previously	previously	RB
cord-296585-yfh5d4io	242	12	led	lead	VBN
cord-296585-yfh5d4io	242	13	to	to	IN
cord-296585-yfh5d4io	242	14	the	the	DT
cord-296585-yfh5d4io	242	15	conclusion	conclusion	NN
cord-296585-yfh5d4io	242	16	that	that	IN
cord-296585-yfh5d4io	242	17	healthy	healthy	JJ
cord-296585-yfh5d4io	242	18	and	and	CC
cord-296585-yfh5d4io	242	19	normal	normal	JJ
cord-296585-yfh5d4io	242	20	lungs	lung	NNS
cord-296585-yfh5d4io	242	21	are	be	VBP
cord-296585-yfh5d4io	242	22	virtually	virtually	RB
cord-296585-yfh5d4io	242	23	sterile	sterile	JJ
cord-296585-yfh5d4io	242	24	.	.	.
cord-296585-yfh5d4io	243	1	This	this	DT
cord-296585-yfh5d4io	243	2	hypothesis	hypothesis	NN
cord-296585-yfh5d4io	243	3	is	be	VBZ
cord-296585-yfh5d4io	243	4	currently	currently	RB
cord-296585-yfh5d4io	243	5	being	be	VBG
cord-296585-yfh5d4io	243	6	revised	revise	VBN
cord-296585-yfh5d4io	243	7	,	,	,
cord-296585-yfh5d4io	243	8	since	since	IN
cord-296585-yfh5d4io	243	9	the	the	DT
cord-296585-yfh5d4io	243	10	introduction	introduction	NN
cord-296585-yfh5d4io	243	11	of	of	IN
cord-296585-yfh5d4io	243	12	16S	16S	NNP
cord-296585-yfh5d4io	243	13	rDNA	rDNA	NNP
cord-296585-yfh5d4io	243	14	based	base	VBN
cord-296585-yfh5d4io	243	15	molecular	molecular	JJ
cord-296585-yfh5d4io	243	16	diagnostics	diagnostic	NNS
cord-296585-yfh5d4io	243	17	has	have	VBZ
cord-296585-yfh5d4io	243	18	shown	show	VBN
cord-296585-yfh5d4io	243	19	that	that	IN
cord-296585-yfh5d4io	243	20	even	even	RB
cord-296585-yfh5d4io	243	21	healthy	healthy	JJ
cord-296585-yfh5d4io	243	22	lungs	lung	NNS
cord-296585-yfh5d4io	243	23	have	have	VBP
cord-296585-yfh5d4io	243	24	a	a	DT
cord-296585-yfh5d4io	243	25	distinct	distinct	JJ
cord-296585-yfh5d4io	243	26	microbial	microbial	JJ
cord-296585-yfh5d4io	243	27	community	community	NN
cord-296585-yfh5d4io	243	28	,	,	,
cord-296585-yfh5d4io	243	29	different	different	JJ
cord-296585-yfh5d4io	243	30	from	from	IN
cord-296585-yfh5d4io	243	31	that	that	DT
cord-296585-yfh5d4io	243	32	seen	see	VBN
cord-296585-yfh5d4io	243	33	in	in	IN
cord-296585-yfh5d4io	243	34	the	the	DT
cord-296585-yfh5d4io	243	35	upper	upper	JJ
cord-296585-yfh5d4io	243	36	respiratory	respiratory	JJ
cord-296585-yfh5d4io	243	37	tract	tract	NN
cord-296585-yfh5d4io	243	38	(	(	-LRB-
cord-296585-yfh5d4io	243	39	180	180	CD
cord-296585-yfh5d4io	243	40	,	,	,
cord-296585-yfh5d4io	243	41	181	181	CD
cord-296585-yfh5d4io	243	42	)	)	-RRB-
cord-296585-yfh5d4io	243	43	.	.	.
cord-296585-yfh5d4io	244	1	This	this	DT
cord-296585-yfh5d4io	244	2	has	have	VBZ
cord-296585-yfh5d4io	244	3	led	lead	VBN
cord-296585-yfh5d4io	244	4	to	to	IN
cord-296585-yfh5d4io	244	5	the	the	DT
cord-296585-yfh5d4io	244	6	concept	concept	NN
cord-296585-yfh5d4io	244	7	of	of	IN
cord-296585-yfh5d4io	244	8	a	a	DT
cord-296585-yfh5d4io	244	9	core	core	JJ
cord-296585-yfh5d4io	244	10	human	human	JJ
cord-296585-yfh5d4io	244	11	lung	lung	NN
cord-296585-yfh5d4io	244	12	microbiome	microbiome	NN
cord-296585-yfh5d4io	244	13	which	which	WDT
cord-296585-yfh5d4io	244	14	can	can	MD
cord-296585-yfh5d4io	244	15	be	be	VB
cord-296585-yfh5d4io	244	16	altered	alter	VBN
cord-296585-yfh5d4io	244	17	in	in	IN
cord-296585-yfh5d4io	244	18	COPD	COPD	NNP
cord-296585-yfh5d4io	244	19	stable	stable	JJ
cord-296585-yfh5d4io	244	20	disease	disease	NN
cord-296585-yfh5d4io	244	21	and	and	CC
cord-296585-yfh5d4io	244	22	during	during	IN
cord-296585-yfh5d4io	244	23	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	244	24	(	(	-LRB-
cord-296585-yfh5d4io	244	25	182	182	CD
cord-296585-yfh5d4io	244	26	)	)	-RRB-
cord-296585-yfh5d4io	244	27	.	.	.
cord-296585-yfh5d4io	245	1	The	the	DT
cord-296585-yfh5d4io	245	2	role	role	NN
cord-296585-yfh5d4io	245	3	of	of	IN
cord-296585-yfh5d4io	245	4	the	the	DT
cord-296585-yfh5d4io	245	5	lung	lung	NN
cord-296585-yfh5d4io	245	6	microbiome	microbiome	NN
cord-296585-yfh5d4io	245	7	in	in	IN
cord-296585-yfh5d4io	245	8	the	the	DT
cord-296585-yfh5d4io	245	9	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	245	10	of	of	IN
cord-296585-yfh5d4io	245	11	COPD	COPD	NNP
cord-296585-yfh5d4io	245	12	by	by	IN
cord-296585-yfh5d4io	245	13	influencing	influence	VBG
cord-296585-yfh5d4io	245	14	host	host	NN
cord-296585-yfh5d4io	245	15	immune	immune	JJ
cord-296585-yfh5d4io	245	16	response	response	NN
cord-296585-yfh5d4io	245	17	has	have	VBZ
cord-296585-yfh5d4io	245	18	also	also	RB
cord-296585-yfh5d4io	245	19	been	be	VBN
cord-296585-yfh5d4io	245	20	suggested	suggest	VBN
cord-296585-yfh5d4io	245	21	(	(	-LRB-
cord-296585-yfh5d4io	245	22	151	151	CD
cord-296585-yfh5d4io	245	23	,	,	,
cord-296585-yfh5d4io	245	24	(	(	-LRB-
cord-296585-yfh5d4io	245	25	183	183	CD
cord-296585-yfh5d4io	245	26	)	)	-RRB-
cord-296585-yfh5d4io	245	27	(	(	-LRB-
cord-296585-yfh5d4io	245	28	184	184	CD
cord-296585-yfh5d4io	245	29	)	)	-RRB-
cord-296585-yfh5d4io	245	30	(	(	-LRB-
cord-296585-yfh5d4io	245	31	185	185	CD
cord-296585-yfh5d4io	245	32	)	)	-RRB-
cord-296585-yfh5d4io	245	33	(	(	-LRB-
cord-296585-yfh5d4io	245	34	186	186	CD
cord-296585-yfh5d4io	245	35	)	)	-RRB-
cord-296585-yfh5d4io	245	36	(	(	-LRB-
cord-296585-yfh5d4io	245	37	187	187	CD
cord-296585-yfh5d4io	245	38	)	)	-RRB-
cord-296585-yfh5d4io	245	39	(	(	-LRB-
cord-296585-yfh5d4io	245	40	188	188	CD
cord-296585-yfh5d4io	245	41	)	)	-RRB-
cord-296585-yfh5d4io	245	42	.	.	.
cord-296585-yfh5d4io	246	1	The	the	DT
cord-296585-yfh5d4io	246	2	stability	stability	NN
cord-296585-yfh5d4io	246	3	of	of	IN
cord-296585-yfh5d4io	246	4	the	the	DT
cord-296585-yfh5d4io	246	5	lung	lung	NN
cord-296585-yfh5d4io	246	6	microbiome	microbiome	NN
cord-296585-yfh5d4io	246	7	has	have	VBZ
cord-296585-yfh5d4io	246	8	profound	profound	JJ
cord-296585-yfh5d4io	246	9	impact	impact	NN
cord-296585-yfh5d4io	246	10	on	on	IN
cord-296585-yfh5d4io	246	11	maintaining	maintain	VBG
cord-296585-yfh5d4io	246	12	local	local	JJ
cord-296585-yfh5d4io	246	13	immune	immune	JJ
cord-296585-yfh5d4io	246	14	homeostasis	homeostasis	NN
cord-296585-yfh5d4io	246	15	(	(	-LRB-
cord-296585-yfh5d4io	246	16	189	189	CD
cord-296585-yfh5d4io	246	17	)	)	-RRB-
cord-296585-yfh5d4io	246	18	.	.	.
cord-296585-yfh5d4io	247	1	According	accord	VBG
cord-296585-yfh5d4io	247	2	to	to	IN
cord-296585-yfh5d4io	247	3	the	the	DT
cord-296585-yfh5d4io	247	4	"	"	``
cord-296585-yfh5d4io	247	5	vicious	vicious	JJ
cord-296585-yfh5d4io	247	6	circle	circle	NN
cord-296585-yfh5d4io	247	7	"	"	''
cord-296585-yfh5d4io	247	8	hypothesis	hypothesis	NN
cord-296585-yfh5d4io	247	9	,	,	,
cord-296585-yfh5d4io	247	10	airway	airway	NN
cord-296585-yfh5d4io	247	11	inflammation	inflammation	NN
cord-296585-yfh5d4io	247	12	and	and	CC
cord-296585-yfh5d4io	247	13	impaired	impaired	JJ
cord-296585-yfh5d4io	247	14	immune	immune	JJ
cord-296585-yfh5d4io	247	15	defenses	defense	NNS
cord-296585-yfh5d4io	247	16	caused	cause	VBN
cord-296585-yfh5d4io	247	17	by	by	IN
cord-296585-yfh5d4io	247	18	either	either	DT
cord-296585-yfh5d4io	247	19	viral	viral	JJ
cord-296585-yfh5d4io	247	20	infections	infection	NNS
cord-296585-yfh5d4io	247	21	or	or	CC
cord-296585-yfh5d4io	247	22	irritant	irritant	JJ
cord-296585-yfh5d4io	247	23	inhalation	inhalation	NN
cord-296585-yfh5d4io	247	24	have	have	VBP
cord-296585-yfh5d4io	247	25	ecological	ecological	JJ
cord-296585-yfh5d4io	247	26	influence	influence	NN
cord-296585-yfh5d4io	247	27	on	on	IN
cord-296585-yfh5d4io	247	28	the	the	DT
cord-296585-yfh5d4io	247	29	airway	airway	NN
cord-296585-yfh5d4io	247	30	microenvironment	microenvironment	NN
cord-296585-yfh5d4io	247	31	and	and	CC
cord-296585-yfh5d4io	247	32	growth	growth	NN
cord-296585-yfh5d4io	247	33	conditions	condition	NNS
cord-296585-yfh5d4io	247	34	that	that	WDT
cord-296585-yfh5d4io	247	35	would	would	MD
cord-296585-yfh5d4io	247	36	eventually	eventually	RB
cord-296585-yfh5d4io	247	37	lead	lead	VB
cord-296585-yfh5d4io	247	38	to	to	IN
cord-296585-yfh5d4io	247	39	dysbiosis	dysbiosis	NN
cord-296585-yfh5d4io	247	40	of	of	IN
cord-296585-yfh5d4io	247	41	the	the	DT
cord-296585-yfh5d4io	247	42	lung	lung	NN
cord-296585-yfh5d4io	247	43	microbiota	microbiota	NN
cord-296585-yfh5d4io	247	44	(	(	-LRB-
cord-296585-yfh5d4io	247	45	182	182	CD
cord-296585-yfh5d4io	247	46	,	,	,
cord-296585-yfh5d4io	247	47	190	190	CD
cord-296585-yfh5d4io	247	48	)	)	-RRB-
cord-296585-yfh5d4io	247	49	.	.	.
cord-296585-yfh5d4io	248	1	The	the	DT
cord-296585-yfh5d4io	248	2	changed	changed	JJ
cord-296585-yfh5d4io	248	3	lung	lung	NN
cord-296585-yfh5d4io	248	4	microbiome	microbiome	NN
cord-296585-yfh5d4io	248	5	would	would	MD
cord-296585-yfh5d4io	248	6	then	then	RB
cord-296585-yfh5d4io	248	7	cause	cause	VB
cord-296585-yfh5d4io	248	8	a	a	DT
cord-296585-yfh5d4io	248	9	maladaptive	maladaptive	JJ
cord-296585-yfh5d4io	248	10	immunological	immunological	JJ
cord-296585-yfh5d4io	248	11	response	response	NN
cord-296585-yfh5d4io	248	12	resulting	result	VBG
cord-296585-yfh5d4io	248	13	in	in	IN
cord-296585-yfh5d4io	248	14	further	further	JJ
cord-296585-yfh5d4io	248	15	inflammation	inflammation	NN
cord-296585-yfh5d4io	248	16	and	and	CC
cord-296585-yfh5d4io	248	17	damage	damage	NN
cord-296585-yfh5d4io	248	18	of	of	IN
cord-296585-yfh5d4io	248	19	the	the	DT
cord-296585-yfh5d4io	248	20	lung	lung	NN
cord-296585-yfh5d4io	248	21	immune	immune	JJ
cord-296585-yfh5d4io	248	22	defenses	defense	NNS
cord-296585-yfh5d4io	248	23	,	,	,
cord-296585-yfh5d4io	248	24	and	and	CC
cord-296585-yfh5d4io	248	25	additional	additional	JJ
cord-296585-yfh5d4io	248	26	alteration	alteration	NN
cord-296585-yfh5d4io	248	27	of	of	IN
cord-296585-yfh5d4io	248	28	the	the	DT
cord-296585-yfh5d4io	248	29	lung	lung	NN
cord-296585-yfh5d4io	248	30	microbiome	microbiome	NN
cord-296585-yfh5d4io	248	31	.	.	.
cord-296585-yfh5d4io	249	1	The	the	DT
cord-296585-yfh5d4io	249	2	chain	chain	NN
cord-296585-yfh5d4io	249	3	of	of	IN
cord-296585-yfh5d4io	249	4	events	event	NNS
cord-296585-yfh5d4io	249	5	thus	thus	RB
cord-296585-yfh5d4io	249	6	generates	generate	VBZ
cord-296585-yfh5d4io	249	7	a	a	DT
cord-296585-yfh5d4io	249	8	vicious	vicious	JJ
cord-296585-yfh5d4io	249	9	circle	circle	NN
cord-296585-yfh5d4io	249	10	that	that	WDT
cord-296585-yfh5d4io	249	11	contributes	contribute	VBZ
cord-296585-yfh5d4io	249	12	to	to	IN
cord-296585-yfh5d4io	249	13	COPD	COPD	NNP
cord-296585-yfh5d4io	249	14	progression	progression	NN
cord-296585-yfh5d4io	249	15	and	and	CC
cord-296585-yfh5d4io	249	16	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	249	17	.	.	.
cord-296585-yfh5d4io	250	1	Several	several	JJ
cord-296585-yfh5d4io	250	2	studies	study	NNS
cord-296585-yfh5d4io	250	3	have	have	VBP
cord-296585-yfh5d4io	250	4	documented	document	VBN
cord-296585-yfh5d4io	250	5	that	that	IN
cord-296585-yfh5d4io	250	6	COPD	COPD	NNP
cord-296585-yfh5d4io	250	7	progression	progression	NN
cord-296585-yfh5d4io	250	8	from	from	IN
cord-296585-yfh5d4io	250	9	stable	stable	JJ
cord-296585-yfh5d4io	250	10	state	state	NN
cord-296585-yfh5d4io	250	11	to	to	IN
cord-296585-yfh5d4io	250	12	an	an	DT
cord-296585-yfh5d4io	250	13	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	250	14	could	could	MD
cord-296585-yfh5d4io	250	15	induce	induce	VB
cord-296585-yfh5d4io	250	16	microbiota	microbiota	NN
cord-296585-yfh5d4io	250	17	shift	shift	VB
cord-296585-yfh5d4io	250	18	in	in	IN
cord-296585-yfh5d4io	250	19	the	the	DT
cord-296585-yfh5d4io	250	20	lower	low	JJR
cord-296585-yfh5d4io	250	21	airway	airway	NN
cord-296585-yfh5d4io	250	22	(	(	-LRB-
cord-296585-yfh5d4io	250	23	bronchioles	bronchiole	NNS
cord-296585-yfh5d4io	250	24	)	)	-RRB-
cord-296585-yfh5d4io	250	25	,	,	,
cord-296585-yfh5d4io	250	26	sputum	sputum	NN
cord-296585-yfh5d4io	250	27	,	,	,
cord-296585-yfh5d4io	250	28	and	and	CC
cord-296585-yfh5d4io	250	29	throat	throat	NN
cord-296585-yfh5d4io	250	30	(	(	-LRB-
cord-296585-yfh5d4io	250	31	151	151	CD
cord-296585-yfh5d4io	250	32	,	,	,
cord-296585-yfh5d4io	250	33	(	(	-LRB-
cord-296585-yfh5d4io	250	34	190	190	CD
cord-296585-yfh5d4io	250	35	)	)	-RRB-
cord-296585-yfh5d4io	250	36	(	(	-LRB-
cord-296585-yfh5d4io	250	37	191	191	CD
cord-296585-yfh5d4io	250	38	)	)	-RRB-
cord-296585-yfh5d4io	250	39	(	(	-LRB-
cord-296585-yfh5d4io	250	40	192	192	CD
cord-296585-yfh5d4io	250	41	)	)	-RRB-
cord-296585-yfh5d4io	250	42	(	(	-LRB-
cord-296585-yfh5d4io	250	43	193	193	CD
cord-296585-yfh5d4io	250	44	)	)	-RRB-
cord-296585-yfh5d4io	250	45	(	(	-LRB-
cord-296585-yfh5d4io	250	46	194	194	CD
cord-296585-yfh5d4io	250	47	)	)	-RRB-
cord-296585-yfh5d4io	250	48	(	(	-LRB-
cord-296585-yfh5d4io	250	49	195	195	CD
cord-296585-yfh5d4io	250	50	)	)	-RRB-
cord-296585-yfh5d4io	250	51	(	(	-LRB-
cord-296585-yfh5d4io	250	52	196	196	CD
cord-296585-yfh5d4io	250	53	)	)	-RRB-
cord-296585-yfh5d4io	250	54	.	.	.
cord-296585-yfh5d4io	251	1	Alteration	alteration	NN
cord-296585-yfh5d4io	251	2	in	in	IN
cord-296585-yfh5d4io	251	3	the	the	DT
cord-296585-yfh5d4io	251	4	microbiome	microbiome	NN
cord-296585-yfh5d4io	251	5	complexity	complexity	NN
cord-296585-yfh5d4io	251	6	or	or	CC
cord-296585-yfh5d4io	251	7	richness	richness	NN
cord-296585-yfh5d4io	251	8	is	be	VBZ
cord-296585-yfh5d4io	251	9	associated	associate	VBN
cord-296585-yfh5d4io	251	10	with	with	IN
cord-296585-yfh5d4io	251	11	the	the	DT
cord-296585-yfh5d4io	251	12	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	251	13	process	process	NN
cord-296585-yfh5d4io	251	14	and	and	CC
cord-296585-yfh5d4io	251	15	changes	change	NNS
cord-296585-yfh5d4io	251	16	in	in	IN
cord-296585-yfh5d4io	251	17	ECM	ECM	NNP
cord-296585-yfh5d4io	251	18	protein	protein	NN
cord-296585-yfh5d4io	251	19	expression	expression	NN
cord-296585-yfh5d4io	251	20	in	in	IN
cord-296585-yfh5d4io	251	21	the	the	DT
cord-296585-yfh5d4io	251	22	lung	lung	NN
cord-296585-yfh5d4io	251	23	,	,	,
cord-296585-yfh5d4io	251	24	as	as	IN
cord-296585-yfh5d4io	251	25	observed	observe	VBN
cord-296585-yfh5d4io	251	26	in	in	IN
cord-296585-yfh5d4io	251	27	COPD	COPD	NNP
cord-296585-yfh5d4io	251	28	(	(	-LRB-
cord-296585-yfh5d4io	251	29	185	185	CD
cord-296585-yfh5d4io	251	30	,	,	,
cord-296585-yfh5d4io	251	31	197	197	CD
cord-296585-yfh5d4io	251	32	)	)	-RRB-
cord-296585-yfh5d4io	251	33	.	.	.
cord-296585-yfh5d4io	252	1	Declined	decline	VBD
cord-296585-yfh5d4io	252	2	diversity	diversity	NN
cord-296585-yfh5d4io	252	3	in	in	IN
cord-296585-yfh5d4io	252	4	the	the	DT
cord-296585-yfh5d4io	252	5	lung	lung	NN
cord-296585-yfh5d4io	252	6	microbiome	microbiome	NN
cord-296585-yfh5d4io	252	7	has	have	VBZ
cord-296585-yfh5d4io	252	8	been	be	VBN
cord-296585-yfh5d4io	252	9	reported	report	VBN
cord-296585-yfh5d4io	252	10	to	to	TO
cord-296585-yfh5d4io	252	11	be	be	VB
cord-296585-yfh5d4io	252	12	related	relate	VBN
cord-296585-yfh5d4io	252	13	to	to	IN
cord-296585-yfh5d4io	252	14	disease	disease	NN
cord-296585-yfh5d4io	252	15	severity	severity	NN
cord-296585-yfh5d4io	252	16	,	,	,
cord-296585-yfh5d4io	252	17	inflammation	inflammation	NN
cord-296585-yfh5d4io	252	18	and	and	CC
cord-296585-yfh5d4io	252	19	decreased	decrease	VBD
cord-296585-yfh5d4io	252	20	lung	lung	NN
cord-296585-yfh5d4io	252	21	functions	function	NNS
cord-296585-yfh5d4io	252	22	in	in	IN
cord-296585-yfh5d4io	252	23	COPD	COPD	NNP
cord-296585-yfh5d4io	252	24	.	.	.
cord-296585-yfh5d4io	253	1	This	this	DT
cord-296585-yfh5d4io	253	2	includes	include	VBZ
cord-296585-yfh5d4io	253	3	the	the	DT
cord-296585-yfh5d4io	253	4	increased	increase	VBN
cord-296585-yfh5d4io	253	5	emphysematous	emphysematous	JJ
cord-296585-yfh5d4io	253	6	destruction	destruction	NN
cord-296585-yfh5d4io	253	7	,	,	,
cord-296585-yfh5d4io	253	8	bronchial	bronchial	JJ
cord-296585-yfh5d4io	253	9	tissue	tissue	NN
cord-296585-yfh5d4io	253	10	remodeling	remodeling	NN
cord-296585-yfh5d4io	253	11	,	,	,
cord-296585-yfh5d4io	253	12	lymphoid	lymphoid	JJ
cord-296585-yfh5d4io	253	13	follicle	follicle	NN
cord-296585-yfh5d4io	253	14	formation	formation	NN
cord-296585-yfh5d4io	253	15	,	,	,
cord-296585-yfh5d4io	253	16	elevated	elevated	JJ
cord-296585-yfh5d4io	253	17	autoantibodies	autoantibody	NNS
cord-296585-yfh5d4io	253	18	,	,	,
cord-296585-yfh5d4io	253	19	and	and	CC
cord-296585-yfh5d4io	253	20	IL-17A	il-17a	JJ
cord-296585-yfh5d4io	253	21	production	production	NN
cord-296585-yfh5d4io	253	22	,	,	,
cord-296585-yfh5d4io	253	23	and	and	CC
cord-296585-yfh5d4io	253	24	finally	finally	RB
cord-296585-yfh5d4io	253	25	increased	increase	VBN
cord-296585-yfh5d4io	253	26	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	253	27	extracellular	extracellular	JJ
cord-296585-yfh5d4io	253	28	traps	trap	NNS
cord-296585-yfh5d4io	253	29	(	(	-LRB-
cord-296585-yfh5d4io	253	30	NET	net	NN
cord-296585-yfh5d4io	253	31	)	)	-RRB-
cord-296585-yfh5d4io	253	32	formation	formation	NN
cord-296585-yfh5d4io	253	33	in	in	IN
cord-296585-yfh5d4io	253	34	the	the	DT
cord-296585-yfh5d4io	253	35	airway	airway	NN
cord-296585-yfh5d4io	253	36	of	of	IN
cord-296585-yfh5d4io	253	37	animal	animal	NN
cord-296585-yfh5d4io	253	38	models	model	NNS
cord-296585-yfh5d4io	253	39	or	or	CC
cord-296585-yfh5d4io	253	40	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	253	41	patients	patient	NNS
cord-296585-yfh5d4io	253	42	(	(	-LRB-
cord-296585-yfh5d4io	253	43	198	198	CD
cord-296585-yfh5d4io	253	44	)	)	-RRB-
cord-296585-yfh5d4io	253	45	(	(	-LRB-
cord-296585-yfh5d4io	253	46	199	199	CD
cord-296585-yfh5d4io	253	47	)	)	-RRB-
cord-296585-yfh5d4io	253	48	(	(	-LRB-
cord-296585-yfh5d4io	253	49	200	200	CD
cord-296585-yfh5d4io	253	50	)	)	-RRB-
cord-296585-yfh5d4io	253	51	(	(	-LRB-
cord-296585-yfh5d4io	253	52	201	201	CD
cord-296585-yfh5d4io	253	53	)	)	-RRB-
cord-296585-yfh5d4io	253	54	.	.	.
cord-296585-yfh5d4io	254	1	It	-PRON-	PRP
cord-296585-yfh5d4io	254	2	has	have	VBZ
cord-296585-yfh5d4io	254	3	recently	recently	RB
cord-296585-yfh5d4io	254	4	been	be	VBN
cord-296585-yfh5d4io	254	5	reported	report	VBN
cord-296585-yfh5d4io	254	6	that	that	IN
cord-296585-yfh5d4io	254	7	lung	lung	NN
cord-296585-yfh5d4io	254	8	microbiome	microbiome	NN
cord-296585-yfh5d4io	254	9	diversity	diversity	NN
cord-296585-yfh5d4io	254	10	is	be	VBZ
cord-296585-yfh5d4io	254	11	also	also	RB
cord-296585-yfh5d4io	254	12	associated	associate	VBN
cord-296585-yfh5d4io	254	13	with	with	IN
cord-296585-yfh5d4io	254	14	genetic	genetic	JJ
cord-296585-yfh5d4io	254	15	factors	factor	NNS
cord-296585-yfh5d4io	254	16	.	.	.
cord-296585-yfh5d4io	255	1	Mannose	mannose	NN
cord-296585-yfh5d4io	255	2	-	-	HYPH
cord-296585-yfh5d4io	255	3	binding	bind	VBG
cord-296585-yfh5d4io	255	4	lectin	lectin	NN
cord-296585-yfh5d4io	255	5	(	(	-LRB-
cord-296585-yfh5d4io	255	6	MBL	MBL	NNP
cord-296585-yfh5d4io	255	7	)	)	-RRB-
cord-296585-yfh5d4io	255	8	deficiency	deficiency	NN
cord-296585-yfh5d4io	255	9	has	have	VBZ
cord-296585-yfh5d4io	255	10	also	also	RB
cord-296585-yfh5d4io	255	11	been	be	VBN
cord-296585-yfh5d4io	255	12	associated	associate	VBN
cord-296585-yfh5d4io	255	13	with	with	IN
cord-296585-yfh5d4io	255	14	disease	disease	NN
cord-296585-yfh5d4io	255	15	severity	severity	NN
cord-296585-yfh5d4io	255	16	and	and	CC
cord-296585-yfh5d4io	255	17	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	255	18	in	in	IN
cord-296585-yfh5d4io	255	19	patients	patient	NNS
cord-296585-yfh5d4io	255	20	with	with	IN
cord-296585-yfh5d4io	255	21	cystic	cystic	JJ
cord-296585-yfh5d4io	255	22	fibrosis	fibrosis	NN
cord-296585-yfh5d4io	255	23	and	and	CC
cord-296585-yfh5d4io	255	24	bronchiectasis	bronchiectasis	NNP
cord-296585-yfh5d4io	255	25	(	(	-LRB-
cord-296585-yfh5d4io	255	26	202	202	CD
cord-296585-yfh5d4io	255	27	)	)	-RRB-
cord-296585-yfh5d4io	255	28	.	.	.
cord-296585-yfh5d4io	256	1	However	however	RB
cord-296585-yfh5d4io	256	2	,	,	,
cord-296585-yfh5d4io	256	3	COPD	COPD	NNP
cord-296585-yfh5d4io	256	4	patients	patient	NNS
cord-296585-yfh5d4io	256	5	with	with	IN
cord-296585-yfh5d4io	256	6	a	a	DT
cord-296585-yfh5d4io	256	7	genetic	genetic	JJ
cord-296585-yfh5d4io	256	8	deficiency	deficiency	NN
cord-296585-yfh5d4io	256	9	in	in	IN
cord-296585-yfh5d4io	256	10	MBL	MBL	NNP
cord-296585-yfh5d4io	256	11	are	be	VBP
cord-296585-yfh5d4io	256	12	less	less	RBR
cord-296585-yfh5d4io	256	13	susceptible	susceptible	JJ
cord-296585-yfh5d4io	256	14	to	to	IN
cord-296585-yfh5d4io	256	15	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	256	16	spp	spp	NNS
cord-296585-yfh5d4io	256	17	.	.	.
cord-296585-yfh5d4io	257	1	colonization	colonization	NN
cord-296585-yfh5d4io	257	2	,	,	,
cord-296585-yfh5d4io	257	3	lowering	lower	VBG
cord-296585-yfh5d4io	257	4	the	the	DT
cord-296585-yfh5d4io	257	5	risk	risk	NN
cord-296585-yfh5d4io	257	6	of	of	IN
cord-296585-yfh5d4io	257	7	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	257	8	while	while	IN
cord-296585-yfh5d4io	257	9	their	-PRON-	PRP$
cord-296585-yfh5d4io	257	10	lung	lung	NN
cord-296585-yfh5d4io	257	11	microbiota	microbiota	NN
cord-296585-yfh5d4io	257	12	is	be	VBZ
cord-296585-yfh5d4io	257	13	more	more	RBR
cord-296585-yfh5d4io	257	14	diverse	diverse	JJ
cord-296585-yfh5d4io	257	15	than	than	IN
cord-296585-yfh5d4io	257	16	normal	normal	JJ
cord-296585-yfh5d4io	257	17	COPD	COPD	NNP
cord-296585-yfh5d4io	257	18	patients	patient	NNS
cord-296585-yfh5d4io	257	19	(	(	-LRB-
cord-296585-yfh5d4io	257	20	203	203	CD
cord-296585-yfh5d4io	257	21	)	)	-RRB-
cord-296585-yfh5d4io	257	22	.	.	.
cord-296585-yfh5d4io	258	1	In	in	IN
cord-296585-yfh5d4io	258	2	this	this	DT
cord-296585-yfh5d4io	258	3	review	review	NN
cord-296585-yfh5d4io	258	4	we	-PRON-	PRP
cord-296585-yfh5d4io	258	5	will	will	MD
cord-296585-yfh5d4io	258	6	focus	focus	VB
cord-296585-yfh5d4io	258	7	on	on	IN
cord-296585-yfh5d4io	258	8	NTHi	NTHi	NNS
cord-296585-yfh5d4io	258	9	,	,	,
cord-296585-yfh5d4io	258	10	one	one	CD
cord-296585-yfh5d4io	258	11	of	of	IN
cord-296585-yfh5d4io	258	12	the	the	DT
cord-296585-yfh5d4io	258	13	dominant	dominant	JJ
cord-296585-yfh5d4io	258	14	genera	genus	NNS
cord-296585-yfh5d4io	258	15	that	that	WDT
cord-296585-yfh5d4io	258	16	is	be	VBZ
cord-296585-yfh5d4io	258	17	relatively	relatively	RB
cord-296585-yfh5d4io	258	18	abundant	abundant	JJ
cord-296585-yfh5d4io	258	19	in	in	IN
cord-296585-yfh5d4io	258	20	the	the	DT
cord-296585-yfh5d4io	258	21	total	total	JJ
cord-296585-yfh5d4io	258	22	COPD	COPD	NNP
cord-296585-yfh5d4io	258	23	-	-	HYPH
cord-296585-yfh5d4io	258	24	dependent	dependent	JJ
cord-296585-yfh5d4io	258	25	lung	lung	NN
cord-296585-yfh5d4io	258	26	microbiome	microbiome	NN
cord-296585-yfh5d4io	258	27	,	,	,
cord-296585-yfh5d4io	258	28	due	due	IN
cord-296585-yfh5d4io	258	29	to	to	IN
cord-296585-yfh5d4io	258	30	its	-PRON-	PRP$
cord-296585-yfh5d4io	258	31	role	role	NN
cord-296585-yfh5d4io	258	32	of	of	IN
cord-296585-yfh5d4io	258	33	infection	infection	NN
cord-296585-yfh5d4io	258	34	in	in	IN
cord-296585-yfh5d4io	258	35	COPD	COPD	NNP
cord-296585-yfh5d4io	258	36	immunological	immunological	JJ
cord-296585-yfh5d4io	258	37	responses	response	NNS
cord-296585-yfh5d4io	258	38	(	(	-LRB-
cord-296585-yfh5d4io	258	39	136	136	CD
cord-296585-yfh5d4io	258	40	,	,	,
cord-296585-yfh5d4io	258	41	149	149	CD
cord-296585-yfh5d4io	258	42	,	,	,
cord-296585-yfh5d4io	258	43	192	192	CD
cord-296585-yfh5d4io	258	44	-	-	SYM
cord-296585-yfh5d4io	258	45	195	195	CD
cord-296585-yfh5d4io	258	46	,	,	,
cord-296585-yfh5d4io	258	47	198	198	CD
cord-296585-yfh5d4io	258	48	,	,	,
cord-296585-yfh5d4io	258	49	204	204	CD
cord-296585-yfh5d4io	258	50	-	-	SYM
cord-296585-yfh5d4io	258	51	206	206	CD
cord-296585-yfh5d4io	258	52	)	)	-RRB-
cord-296585-yfh5d4io	258	53	.	.	.
cord-296585-yfh5d4io	259	1	The	the	DT
cord-296585-yfh5d4io	259	2	microbiology	microbiology	NN
cord-296585-yfh5d4io	259	3	of	of	IN
cord-296585-yfh5d4io	259	4	H.	H.	NNP
cord-296585-yfh5d4io	259	5	influenzae	influenzae	NN
cord-296585-yfh5d4io	259	6	has	have	VBZ
cord-296585-yfh5d4io	259	7	recently	recently	RB
cord-296585-yfh5d4io	259	8	been	be	VBN
cord-296585-yfh5d4io	259	9	reviewed	review	VBN
cord-296585-yfh5d4io	259	10	in	in	IN
cord-296585-yfh5d4io	259	11	detail	detail	NN
cord-296585-yfh5d4io	259	12	by	by	IN
cord-296585-yfh5d4io	259	13	our	-PRON-	PRP$
cord-296585-yfh5d4io	259	14	group	group	NN
cord-296585-yfh5d4io	259	15	and	and	CC
cord-296585-yfh5d4io	259	16	others	other	NNS
cord-296585-yfh5d4io	259	17	(	(	-LRB-
cord-296585-yfh5d4io	259	18	4	4	CD
cord-296585-yfh5d4io	259	19	,	,	,
cord-296585-yfh5d4io	259	20	5	5	CD
cord-296585-yfh5d4io	259	21	,	,	,
cord-296585-yfh5d4io	259	22	207	207	CD
cord-296585-yfh5d4io	259	23	)	)	-RRB-
cord-296585-yfh5d4io	259	24	.	.	.
cord-296585-yfh5d4io	260	1	It	-PRON-	PRP
cord-296585-yfh5d4io	260	2	is	be	VBZ
cord-296585-yfh5d4io	260	3	a	a	DT
cord-296585-yfh5d4io	260	4	Gramnegative	Gramnegative	NNP
cord-296585-yfh5d4io	260	5	coccobacillus	coccobacillus	NN
cord-296585-yfh5d4io	260	6	that	that	WDT
cord-296585-yfh5d4io	260	7	commonly	commonly	RB
cord-296585-yfh5d4io	260	8	colonizes	colonize	VBZ
cord-296585-yfh5d4io	260	9	the	the	DT
cord-296585-yfh5d4io	260	10	human	human	JJ
cord-296585-yfh5d4io	260	11	nasopharynx	nasopharynx	NN
cord-296585-yfh5d4io	260	12	,	,	,
cord-296585-yfh5d4io	260	13	and	and	CC
cord-296585-yfh5d4io	260	14	is	be	VBZ
cord-296585-yfh5d4io	260	15	typed	type	VBN
cord-296585-yfh5d4io	260	16	as	as	IN
cord-296585-yfh5d4io	260	17	capsulated	capsulate	VBN
cord-296585-yfh5d4io	260	18	(	(	-LRB-
cord-296585-yfh5d4io	260	19	type	type	VB
cord-296585-yfh5d4io	260	20	a	a	NNP
cord-296585-yfh5d4io	260	21	-	-	HYPH
cord-296585-yfh5d4io	260	22	f	f	NN
cord-296585-yfh5d4io	260	23	)	)	-RRB-
cord-296585-yfh5d4io	260	24	or	or	CC
cord-296585-yfh5d4io	260	25	nonencapsulated	nonencapsulate	VBN
cord-296585-yfh5d4io	260	26	strains	strain	NNS
cord-296585-yfh5d4io	260	27	(	(	-LRB-
cord-296585-yfh5d4io	260	28	NTHi	NTHi	NNS
cord-296585-yfh5d4io	260	29	)	)	-RRB-
cord-296585-yfh5d4io	260	30	.	.	.
cord-296585-yfh5d4io	261	1	H.	H.	NNP
cord-296585-yfh5d4io	261	2	influenzae	influenzae	NN
cord-296585-yfh5d4io	261	3	may	may	MD
cord-296585-yfh5d4io	261	4	cause	cause	VB
cord-296585-yfh5d4io	261	5	both	both	CC
cord-296585-yfh5d4io	261	6	invasive	invasive	JJ
cord-296585-yfh5d4io	261	7	and	and	CC
cord-296585-yfh5d4io	261	8	mucosal	mucosal	JJ
cord-296585-yfh5d4io	261	9	disease	disease	NN
cord-296585-yfh5d4io	261	10	(	(	-LRB-
cord-296585-yfh5d4io	261	11	208	208	CD
cord-296585-yfh5d4io	261	12	)	)	-RRB-
cord-296585-yfh5d4io	261	13	.	.	.
cord-296585-yfh5d4io	262	1	Since	since	IN
cord-296585-yfh5d4io	262	2	the	the	DT
cord-296585-yfh5d4io	262	3	introduction	introduction	NN
cord-296585-yfh5d4io	262	4	of	of	IN
cord-296585-yfh5d4io	262	5	capsule	capsule	NN
cord-296585-yfh5d4io	262	6	polysaccharide	polysaccharide	NN
cord-296585-yfh5d4io	262	7	conjugate	conjugate	VBP
cord-296585-yfh5d4io	262	8	vaccines	vaccine	NNS
cord-296585-yfh5d4io	262	9	against	against	IN
cord-296585-yfh5d4io	262	10	type	type	NN
cord-296585-yfh5d4io	262	11	b	b	NN
cord-296585-yfh5d4io	262	12	(	(	-LRB-
cord-296585-yfh5d4io	262	13	Hib	Hib	NNP
cord-296585-yfh5d4io	262	14	)	)	-RRB-
cord-296585-yfh5d4io	262	15	,	,	,
cord-296585-yfh5d4io	262	16	NTHi	NTHi	NNS
cord-296585-yfh5d4io	262	17	dominate	dominate	VBP
cord-296585-yfh5d4io	262	18	,	,	,
cord-296585-yfh5d4io	262	19	followed	follow	VBN
cord-296585-yfh5d4io	262	20	by	by	IN
cord-296585-yfh5d4io	262	21	capsule	capsule	NN
cord-296585-yfh5d4io	262	22	type	type	NN
cord-296585-yfh5d4io	262	23	f	f	NNP
cord-296585-yfh5d4io	262	24	(	(	-LRB-
cord-296585-yfh5d4io	262	25	Hif	Hif	NNP
cord-296585-yfh5d4io	262	26	)	)	-RRB-
cord-296585-yfh5d4io	262	27	(	(	-LRB-
cord-296585-yfh5d4io	262	28	209	209	CD
cord-296585-yfh5d4io	262	29	,	,	,
cord-296585-yfh5d4io	262	30	210	210	CD
cord-296585-yfh5d4io	262	31	)	)	-RRB-
cord-296585-yfh5d4io	262	32	.	.	.
cord-296585-yfh5d4io	263	1	Mucosal	Mucosal	NNP
cord-296585-yfh5d4io	263	2	infections	infection	NNS
cord-296585-yfh5d4io	263	3	,	,	,
cord-296585-yfh5d4io	263	4	including	include	VBG
cord-296585-yfh5d4io	263	5	acute	acute	JJ
cord-296585-yfh5d4io	263	6	otitis	otitis	NN
cord-296585-yfh5d4io	263	7	media	medium	NNS
cord-296585-yfh5d4io	263	8	,	,	,
cord-296585-yfh5d4io	263	9	sinusitis	sinusitis	NN
cord-296585-yfh5d4io	263	10	,	,	,
cord-296585-yfh5d4io	263	11	and	and	CC
cord-296585-yfh5d4io	263	12	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	263	13	in	in	IN
cord-296585-yfh5d4io	263	14	COPD	COPD	NNP
cord-296585-yfh5d4io	263	15	,	,	,
cord-296585-yfh5d4io	263	16	are	be	VBP
cord-296585-yfh5d4io	263	17	nowadays	nowadays	RB
cord-296585-yfh5d4io	263	18	mainly	mainly	RB
cord-296585-yfh5d4io	263	19	associated	associate	VBN
cord-296585-yfh5d4io	263	20	with	with	IN
cord-296585-yfh5d4io	263	21	NTHi	NTHi	NNS
cord-296585-yfh5d4io	263	22	.	.	.
cord-296585-yfh5d4io	264	1	There	there	EX
cord-296585-yfh5d4io	264	2	has	have	VBZ
cord-296585-yfh5d4io	264	3	also	also	RB
cord-296585-yfh5d4io	264	4	been	be	VBN
cord-296585-yfh5d4io	264	5	a	a	DT
cord-296585-yfh5d4io	264	6	significant	significant	JJ
cord-296585-yfh5d4io	264	7	shift	shift	NN
cord-296585-yfh5d4io	264	8	in	in	IN
cord-296585-yfh5d4io	264	9	the	the	DT
cord-296585-yfh5d4io	264	10	epidemiology	epidemiology	NN
cord-296585-yfh5d4io	264	11	of	of	IN
cord-296585-yfh5d4io	264	12	severe	severe	JJ
cord-296585-yfh5d4io	264	13	invasive	invasive	JJ
cord-296585-yfh5d4io	264	14	disease	disease	NN
cord-296585-yfh5d4io	264	15	,	,	,
cord-296585-yfh5d4io	264	16	from	from	IN
cord-296585-yfh5d4io	264	17	Hib	Hib	NNP
cord-296585-yfh5d4io	264	18	infections	infection	NNS
cord-296585-yfh5d4io	264	19	in	in	IN
cord-296585-yfh5d4io	264	20	small	small	JJ
cord-296585-yfh5d4io	264	21	children	child	NNS
cord-296585-yfh5d4io	264	22	to	to	IN
cord-296585-yfh5d4io	264	23	NTHi	NTHi	NNS
cord-296585-yfh5d4io	264	24	in	in	IN
cord-296585-yfh5d4io	264	25	adults	adult	NNS
cord-296585-yfh5d4io	264	26	(	(	-LRB-
cord-296585-yfh5d4io	264	27	210	210	CD
cord-296585-yfh5d4io	264	28	,	,	,
cord-296585-yfh5d4io	264	29	211	211	CD
cord-296585-yfh5d4io	264	30	)	)	-RRB-
cord-296585-yfh5d4io	264	31	.	.	.
cord-296585-yfh5d4io	265	1	The	the	DT
cord-296585-yfh5d4io	265	2	most	most	RBS
cord-296585-yfh5d4io	265	3	common	common	JJ
cord-296585-yfh5d4io	265	4	principal	principal	JJ
cord-296585-yfh5d4io	265	5	infection	infection	NN
cord-296585-yfh5d4io	265	6	focus	focus	NN
cord-296585-yfh5d4io	265	7	by	by	IN
cord-296585-yfh5d4io	265	8	H.	H.	NNP
cord-296585-yfh5d4io	265	9	influenzae	influenzae	NN
cord-296585-yfh5d4io	265	10	is	be	VBZ
cord-296585-yfh5d4io	265	11	now	now	RB
cord-296585-yfh5d4io	265	12	community	community	NN
cord-296585-yfh5d4io	265	13	acquired	acquire	VBD
cord-296585-yfh5d4io	265	14	pneumonia	pneumonia	NN
cord-296585-yfh5d4io	265	15	(	(	-LRB-
cord-296585-yfh5d4io	265	16	CAP	CAP	NNP
cord-296585-yfh5d4io	265	17	)	)	-RRB-
cord-296585-yfh5d4io	265	18	,	,	,
cord-296585-yfh5d4io	265	19	whereas	whereas	IN
cord-296585-yfh5d4io	265	20	the	the	DT
cord-296585-yfh5d4io	265	21	incidence	incidence	NN
cord-296585-yfh5d4io	265	22	of	of	IN
cord-296585-yfh5d4io	265	23	historically	historically	RB
cord-296585-yfh5d4io	265	24	common	common	JJ
cord-296585-yfh5d4io	265	25	diagnoses	diagnosis	NNS
cord-296585-yfh5d4io	265	26	such	such	JJ
cord-296585-yfh5d4io	265	27	as	as	IN
cord-296585-yfh5d4io	265	28	meningitis	meningitis	NN
cord-296585-yfh5d4io	265	29	and	and	CC
cord-296585-yfh5d4io	265	30	epiglottitis	epiglottitis	NNP
cord-296585-yfh5d4io	265	31	have	have	VBP
cord-296585-yfh5d4io	265	32	significantly	significantly	RB
cord-296585-yfh5d4io	265	33	decreased	decrease	VBN
cord-296585-yfh5d4io	265	34	(	(	-LRB-
cord-296585-yfh5d4io	265	35	210	210	CD
cord-296585-yfh5d4io	265	36	,	,	,
cord-296585-yfh5d4io	265	37	211	211	CD
cord-296585-yfh5d4io	265	38	)	)	-RRB-
cord-296585-yfh5d4io	265	39	.	.	.
cord-296585-yfh5d4io	266	1	Patients	patient	NNS
cord-296585-yfh5d4io	266	2	with	with	IN
cord-296585-yfh5d4io	266	3	underlying	underlying	JJ
cord-296585-yfh5d4io	266	4	conditions	condition	NNS
cord-296585-yfh5d4io	266	5	,	,	,
cord-296585-yfh5d4io	266	6	notably	notably	RB
cord-296585-yfh5d4io	266	7	COPD	COPD	NNP
cord-296585-yfh5d4io	266	8	,	,	,
cord-296585-yfh5d4io	266	9	seem	seem	VBP
cord-296585-yfh5d4io	266	10	to	to	TO
cord-296585-yfh5d4io	266	11	be	be	VB
cord-296585-yfh5d4io	266	12	at	at	IN
cord-296585-yfh5d4io	266	13	higher	high	JJR
cord-296585-yfh5d4io	266	14	risk	risk	NN
cord-296585-yfh5d4io	266	15	for	for	IN
cord-296585-yfh5d4io	266	16	invasive	invasive	JJ
cord-296585-yfh5d4io	266	17	infections	infection	NNS
cord-296585-yfh5d4io	266	18	(	(	-LRB-
cord-296585-yfh5d4io	266	19	209	209	CD
cord-296585-yfh5d4io	266	20	)	)	-RRB-
cord-296585-yfh5d4io	266	21	.	.	.
cord-296585-yfh5d4io	267	1	There	there	EX
cord-296585-yfh5d4io	267	2	is	be	VBZ
cord-296585-yfh5d4io	267	3	consensus	consensus	NN
cord-296585-yfh5d4io	267	4	that	that	IN
cord-296585-yfh5d4io	267	5	H.	H.	NNP
cord-296585-yfh5d4io	267	6	influenzae	influenzae	NN
cord-296585-yfh5d4io	267	7	is	be	VBZ
cord-296585-yfh5d4io	267	8	one	one	CD
cord-296585-yfh5d4io	267	9	of	of	IN
cord-296585-yfh5d4io	267	10	the	the	DT
cord-296585-yfh5d4io	267	11	key	key	JJ
cord-296585-yfh5d4io	267	12	bacterial	bacterial	JJ
cord-296585-yfh5d4io	267	13	pathogens	pathogen	NNS
cord-296585-yfh5d4io	267	14	involved	involve	VBN
cord-296585-yfh5d4io	267	15	in	in	IN
cord-296585-yfh5d4io	267	16	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	267	17	of	of	IN
cord-296585-yfh5d4io	267	18	both	both	CC
cord-296585-yfh5d4io	267	19	stable	stable	JJ
cord-296585-yfh5d4io	267	20	COPD	COPD	NNP
cord-296585-yfh5d4io	267	21	disease	disease	NN
cord-296585-yfh5d4io	267	22	and	and	CC
cord-296585-yfh5d4io	267	23	acute	acute	JJ
cord-296585-yfh5d4io	267	24	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	267	25	(	(	-LRB-
cord-296585-yfh5d4io	267	26	207	207	CD
cord-296585-yfh5d4io	267	27	)	)	-RRB-
cord-296585-yfh5d4io	267	28	.	.	.
cord-296585-yfh5d4io	268	1	However	however	RB
cord-296585-yfh5d4io	268	2	,	,	,
cord-296585-yfh5d4io	268	3	the	the	DT
cord-296585-yfh5d4io	268	4	relative	relative	JJ
cord-296585-yfh5d4io	268	5	abundance	abundance	NN
cord-296585-yfh5d4io	268	6	and	and	CC
cord-296585-yfh5d4io	268	7	significance	significance	NN
cord-296585-yfh5d4io	268	8	of	of	IN
cord-296585-yfh5d4io	268	9	NTHi	NTHi	NNS
cord-296585-yfh5d4io	268	10	in	in	IN
cord-296585-yfh5d4io	268	11	COPD	COPD	NNP
cord-296585-yfh5d4io	268	12	varies	vary	VBZ
cord-296585-yfh5d4io	268	13	between	between	IN
cord-296585-yfh5d4io	268	14	different	different	JJ
cord-296585-yfh5d4io	268	15	studies	study	NNS
cord-296585-yfh5d4io	268	16	.	.	.
cord-296585-yfh5d4io	269	1	Several	several	JJ
cord-296585-yfh5d4io	269	2	factors	factor	NNS
cord-296585-yfh5d4io	269	3	,	,	,
cord-296585-yfh5d4io	269	4	such	such	JJ
cord-296585-yfh5d4io	269	5	as	as	IN
cord-296585-yfh5d4io	269	6	sampling	sampling	NN
cord-296585-yfh5d4io	269	7	methodology	methodology	NN
cord-296585-yfh5d4io	269	8	,	,	,
cord-296585-yfh5d4io	269	9	choice	choice	NN
cord-296585-yfh5d4io	269	10	of	of	IN
cord-296585-yfh5d4io	269	11	microbiological	microbiological	JJ
cord-296585-yfh5d4io	269	12	analysis	analysis	NN
cord-296585-yfh5d4io	269	13	and	and	CC
cord-296585-yfh5d4io	269	14	,	,	,
cord-296585-yfh5d4io	269	15	if	if	IN
cord-296585-yfh5d4io	269	16	the	the	DT
cord-296585-yfh5d4io	269	17	patient	patient	NN
cord-296585-yfh5d4io	269	18	has	have	VBZ
cord-296585-yfh5d4io	269	19	a	a	DT
cord-296585-yfh5d4io	269	20	stable	stable	JJ
cord-296585-yfh5d4io	269	21	disease	disease	NN
cord-296585-yfh5d4io	269	22	or	or	CC
cord-296585-yfh5d4io	269	23	an	an	DT
cord-296585-yfh5d4io	269	24	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	269	25	,	,	,
cord-296585-yfh5d4io	269	26	or	or	CC
cord-296585-yfh5d4io	269	27	has	have	VBZ
cord-296585-yfh5d4io	269	28	been	be	VBN
cord-296585-yfh5d4io	269	29	subject	subject	JJ
cord-296585-yfh5d4io	269	30	to	to	IN
cord-296585-yfh5d4io	269	31	previous	previous	JJ
cord-296585-yfh5d4io	269	32	antibiotic	antibiotic	JJ
cord-296585-yfh5d4io	269	33	therapies	therapy	NNS
cord-296585-yfh5d4io	269	34	,	,	,
cord-296585-yfh5d4io	269	35	tend	tend	VBP
cord-296585-yfh5d4io	269	36	to	to	TO
cord-296585-yfh5d4io	269	37	affect	affect	VB
cord-296585-yfh5d4io	269	38	the	the	DT
cord-296585-yfh5d4io	269	39	outcome	outcome	NN
cord-296585-yfh5d4io	269	40	of	of	IN
cord-296585-yfh5d4io	269	41	the	the	DT
cord-296585-yfh5d4io	269	42	studies	study	NNS
cord-296585-yfh5d4io	269	43	(	(	-LRB-
cord-296585-yfh5d4io	269	44	212	212	CD
cord-296585-yfh5d4io	269	45	)	)	-RRB-
cord-296585-yfh5d4io	269	46	.	.	.
cord-296585-yfh5d4io	270	1	Common	common	JJ
cord-296585-yfh5d4io	270	2	sampling	sampling	NN
cord-296585-yfh5d4io	270	3	methods	method	NNS
cord-296585-yfh5d4io	270	4	from	from	IN
cord-296585-yfh5d4io	270	5	the	the	DT
cord-296585-yfh5d4io	270	6	lower	low	JJR
cord-296585-yfh5d4io	270	7	respiratory	respiratory	JJ
cord-296585-yfh5d4io	270	8	tract	tract	NN
cord-296585-yfh5d4io	270	9	include	include	VBP
cord-296585-yfh5d4io	270	10	both	both	DT
cord-296585-yfh5d4io	270	11	bronchoscopy	bronchoscopy	NN
cord-296585-yfh5d4io	270	12	techniques	technique	NNS
cord-296585-yfh5d4io	270	13	such	such	JJ
cord-296585-yfh5d4io	270	14	as	as	IN
cord-296585-yfh5d4io	270	15	protected	protect	VBN
cord-296585-yfh5d4io	270	16	specimen	specimen	NN
cord-296585-yfh5d4io	270	17	brush	brush	NN
cord-296585-yfh5d4io	270	18	(	(	-LRB-
cord-296585-yfh5d4io	270	19	PSB	PSB	NNP
cord-296585-yfh5d4io	270	20	)	)	-RRB-
cord-296585-yfh5d4io	270	21	and	and	CC
cord-296585-yfh5d4io	270	22	collection	collection	NN
cord-296585-yfh5d4io	270	23	of	of	IN
cord-296585-yfh5d4io	270	24	BAL	bal	NN
cord-296585-yfh5d4io	270	25	fluid	fluid	NN
cord-296585-yfh5d4io	270	26	as	as	RB
cord-296585-yfh5d4io	270	27	well	well	RB
cord-296585-yfh5d4io	270	28	as	as	IN
cord-296585-yfh5d4io	270	29	non	non	JJ
cord-296585-yfh5d4io	270	30	-	-	JJ
cord-296585-yfh5d4io	270	31	invasive	invasive	JJ
cord-296585-yfh5d4io	270	32	methods	method	NNS
cord-296585-yfh5d4io	270	33	like	like	IN
cord-296585-yfh5d4io	270	34	sputum	sputum	NN
cord-296585-yfh5d4io	270	35	sampling	sampling	NN
cord-296585-yfh5d4io	270	36	(	(	-LRB-
cord-296585-yfh5d4io	270	37	213	213	CD
cord-296585-yfh5d4io	270	38	)	)	-RRB-
cord-296585-yfh5d4io	270	39	.	.	.
cord-296585-yfh5d4io	271	1	All	all	DT
cord-296585-yfh5d4io	271	2	of	of	IN
cord-296585-yfh5d4io	271	3	these	these	DT
cord-296585-yfh5d4io	271	4	methods	method	NNS
cord-296585-yfh5d4io	271	5	,	,	,
cord-296585-yfh5d4io	271	6	particularly	particularly	RB
cord-296585-yfh5d4io	271	7	sputum	sputum	NN
cord-296585-yfh5d4io	271	8	,	,	,
cord-296585-yfh5d4io	271	9	are	be	VBP
cord-296585-yfh5d4io	271	10	to	to	IN
cord-296585-yfh5d4io	271	11	some	some	DT
cord-296585-yfh5d4io	271	12	extent	extent	NN
cord-296585-yfh5d4io	271	13	subject	subject	JJ
cord-296585-yfh5d4io	271	14	to	to	IN
cord-296585-yfh5d4io	271	15	the	the	DT
cord-296585-yfh5d4io	271	16	risk	risk	NN
cord-296585-yfh5d4io	271	17	of	of	IN
cord-296585-yfh5d4io	271	18	contamination	contamination	NN
cord-296585-yfh5d4io	271	19	from	from	IN
cord-296585-yfh5d4io	271	20	the	the	DT
cord-296585-yfh5d4io	271	21	normal	normal	JJ
cord-296585-yfh5d4io	271	22	microbial	microbial	JJ
cord-296585-yfh5d4io	271	23	flora	flora	NNS
cord-296585-yfh5d4io	271	24	of	of	IN
cord-296585-yfh5d4io	271	25	the	the	DT
cord-296585-yfh5d4io	271	26	oro	oro	NNP
cord-296585-yfh5d4io	271	27	-	-	HYPH
cord-296585-yfh5d4io	271	28	and	and	CC
cord-296585-yfh5d4io	271	29	nasopharynx	nasopharynx	NN
cord-296585-yfh5d4io	271	30	,	,	,
cord-296585-yfh5d4io	271	31	which	which	WDT
cord-296585-yfh5d4io	271	32	might	may	MD
cord-296585-yfh5d4io	271	33	reduce	reduce	VB
cord-296585-yfh5d4io	271	34	their	-PRON-	PRP$
cord-296585-yfh5d4io	271	35	specificity	specificity	NN
cord-296585-yfh5d4io	271	36	(	(	-LRB-
cord-296585-yfh5d4io	271	37	213	213	CD
cord-296585-yfh5d4io	271	38	)	)	-RRB-
cord-296585-yfh5d4io	271	39	.	.	.
cord-296585-yfh5d4io	272	1	However	however	RB
cord-296585-yfh5d4io	272	2	,	,	,
cord-296585-yfh5d4io	272	3	several	several	JJ
cord-296585-yfh5d4io	272	4	studies	study	NNS
cord-296585-yfh5d4io	272	5	still	still	RB
cord-296585-yfh5d4io	272	6	show	show	VBP
cord-296585-yfh5d4io	272	7	a	a	DT
cord-296585-yfh5d4io	272	8	distinct	distinct	JJ
cord-296585-yfh5d4io	272	9	association	association	NN
cord-296585-yfh5d4io	272	10	between	between	IN
cord-296585-yfh5d4io	272	11	lower	low	JJR
cord-296585-yfh5d4io	272	12	respiratory	respiratory	JJ
cord-296585-yfh5d4io	272	13	tract	tract	NN
cord-296585-yfh5d4io	272	14	samples	sample	NNS
cord-296585-yfh5d4io	272	15	and	and	CC
cord-296585-yfh5d4io	272	16	clinical	clinical	JJ
cord-296585-yfh5d4io	272	17	parameters	parameter	NNS
cord-296585-yfh5d4io	272	18	in	in	IN
cord-296585-yfh5d4io	272	19	COPD	COPD	NNP
cord-296585-yfh5d4io	272	20	patients	patient	NNS
cord-296585-yfh5d4io	272	21	,	,	,
cord-296585-yfh5d4io	272	22	making	make	VBG
cord-296585-yfh5d4io	272	23	the	the	DT
cord-296585-yfh5d4io	272	24	information	information	NN
cord-296585-yfh5d4io	272	25	valuable	valuable	JJ
cord-296585-yfh5d4io	272	26	(	(	-LRB-
cord-296585-yfh5d4io	272	27	214	214	CD
cord-296585-yfh5d4io	272	28	)	)	-RRB-
cord-296585-yfh5d4io	272	29	.	.	.
cord-296585-yfh5d4io	273	1	Cultivable	cultivable	JJ
cord-296585-yfh5d4io	273	2	bacteria	bacteria	NNS
cord-296585-yfh5d4io	273	3	are	be	VBP
cord-296585-yfh5d4io	273	4	seldom	seldom	RB
cord-296585-yfh5d4io	273	5	found	find	VBN
cord-296585-yfh5d4io	273	6	in	in	IN
cord-296585-yfh5d4io	273	7	the	the	DT
cord-296585-yfh5d4io	273	8	lower	low	JJR
cord-296585-yfh5d4io	273	9	airways	airway	NNS
cord-296585-yfh5d4io	273	10	of	of	IN
cord-296585-yfh5d4io	273	11	healthy	healthy	JJ
cord-296585-yfh5d4io	273	12	individuals	individual	NNS
cord-296585-yfh5d4io	273	13	(	(	-LRB-
cord-296585-yfh5d4io	273	14	215	215	CD
cord-296585-yfh5d4io	273	15	)	)	-RRB-
cord-296585-yfh5d4io	273	16	,	,	,
cord-296585-yfh5d4io	273	17	whereas	whereas	IN
cord-296585-yfh5d4io	273	18	COPD	COPD	NNP
cord-296585-yfh5d4io	273	19	patients	patient	NNS
cord-296585-yfh5d4io	273	20	show	show	VBP
cord-296585-yfh5d4io	273	21	bacterial	bacterial	JJ
cord-296585-yfh5d4io	273	22	growth	growth	NN
cord-296585-yfh5d4io	273	23	in	in	IN
cord-296585-yfh5d4io	273	24	30	30	CD
cord-296585-yfh5d4io	273	25	-	-	SYM
cord-296585-yfh5d4io	273	26	50	50	CD
cord-296585-yfh5d4io	273	27	%	%	NN
cord-296585-yfh5d4io	273	28	of	of	IN
cord-296585-yfh5d4io	273	29	cases	case	NNS
cord-296585-yfh5d4io	273	30	even	even	RB
cord-296585-yfh5d4io	273	31	during	during	IN
cord-296585-yfh5d4io	273	32	stable	stable	JJ
cord-296585-yfh5d4io	273	33	disease	disease	NN
cord-296585-yfh5d4io	273	34	(	(	-LRB-
cord-296585-yfh5d4io	273	35	Table	table	NN
cord-296585-yfh5d4io	273	36	1	1	CD
cord-296585-yfh5d4io	273	37	)	)	-RRB-
cord-296585-yfh5d4io	273	38	.	.	.
cord-296585-yfh5d4io	274	1	On	on	IN
cord-296585-yfh5d4io	274	2	top	top	NN
cord-296585-yfh5d4io	274	3	of	of	IN
cord-296585-yfh5d4io	274	4	that	that	DT
cord-296585-yfh5d4io	274	5	,	,	,
cord-296585-yfh5d4io	274	6	several	several	JJ
cord-296585-yfh5d4io	274	7	studies	study	NNS
cord-296585-yfh5d4io	274	8	have	have	VBP
cord-296585-yfh5d4io	274	9	shown	show	VBN
cord-296585-yfh5d4io	274	10	a	a	DT
cord-296585-yfh5d4io	274	11	significant	significant	JJ
cord-296585-yfh5d4io	274	12	increase	increase	NN
cord-296585-yfh5d4io	274	13	in	in	IN
cord-296585-yfh5d4io	274	14	the	the	DT
cord-296585-yfh5d4io	274	15	Proteobacteria	Proteobacteria	NNP
cord-296585-yfh5d4io	274	16	phylum	phylum	NN
cord-296585-yfh5d4io	274	17	,	,	,
cord-296585-yfh5d4io	274	18	which	which	WDT
cord-296585-yfh5d4io	274	19	includes	include	VBZ
cord-296585-yfh5d4io	274	20	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	274	21	spp	spp	NNS
cord-296585-yfh5d4io	274	22	.	.	.
cord-296585-yfh5d4io	275	1	,	,	,
cord-296585-yfh5d4io	275	2	in	in	IN
cord-296585-yfh5d4io	275	3	individuals	individual	NNS
cord-296585-yfh5d4io	275	4	with	with	IN
cord-296585-yfh5d4io	275	5	both	both	DT
cord-296585-yfh5d4io	275	6	stable	stable	JJ
cord-296585-yfh5d4io	275	7	disease	disease	NN
cord-296585-yfh5d4io	275	8	and	and	CC
cord-296585-yfh5d4io	275	9	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	275	10	(	(	-LRB-
cord-296585-yfh5d4io	275	11	Table	table	NN
cord-296585-yfh5d4io	275	12	2	2	CD
cord-296585-yfh5d4io	275	13	)	)	-RRB-
cord-296585-yfh5d4io	275	14	.	.	.
cord-296585-yfh5d4io	276	1	NTHi	NTHi	NNP
cord-296585-yfh5d4io	276	2	is	be	VBZ
cord-296585-yfh5d4io	276	3	consistently	consistently	RB
cord-296585-yfh5d4io	276	4	one	one	CD
cord-296585-yfh5d4io	276	5	of	of	IN
cord-296585-yfh5d4io	276	6	the	the	DT
cord-296585-yfh5d4io	276	7	predominating	predominating	JJ
cord-296585-yfh5d4io	276	8	bacterial	bacterial	JJ
cord-296585-yfh5d4io	276	9	species	specie	NNS
cord-296585-yfh5d4io	276	10	isolated	isolate	VBN
cord-296585-yfh5d4io	276	11	in	in	IN
cord-296585-yfh5d4io	276	12	those	those	DT
cord-296585-yfh5d4io	276	13	cultures	culture	NNS
cord-296585-yfh5d4io	276	14	;	;	:
cord-296585-yfh5d4io	276	15	other	other	JJ
cord-296585-yfh5d4io	276	16	important	important	JJ
cord-296585-yfh5d4io	276	17	pathogens	pathogen	NNS
cord-296585-yfh5d4io	276	18	include	include	VBP
cord-296585-yfh5d4io	276	19	S.	S.	NNP
cord-296585-yfh5d4io	276	20	pneumoniae	pneumoniae	NN
cord-296585-yfh5d4io	276	21	,	,	,
cord-296585-yfh5d4io	276	22	M.	M.	NNP
cord-296585-yfh5d4io	276	23	catarrhalis	catarrhalis	NNP
cord-296585-yfh5d4io	276	24	,	,	,
cord-296585-yfh5d4io	276	25	and	and	CC
cord-296585-yfh5d4io	276	26	P.	P.	NNP
cord-296585-yfh5d4io	276	27	aeruginosa	aeruginosa	NNP
cord-296585-yfh5d4io	276	28	(	(	-LRB-
cord-296585-yfh5d4io	276	29	219	219	CD
cord-296585-yfh5d4io	276	30	)	)	-RRB-
cord-296585-yfh5d4io	276	31	.	.	.
cord-296585-yfh5d4io	277	1	During	during	IN
cord-296585-yfh5d4io	277	2	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	277	3	,	,	,
cord-296585-yfh5d4io	277	4	the	the	DT
cord-296585-yfh5d4io	277	5	bacterial	bacterial	JJ
cord-296585-yfh5d4io	277	6	load	load	NN
cord-296585-yfh5d4io	277	7	is	be	VBZ
cord-296585-yfh5d4io	277	8	increased	increase	VBN
cord-296585-yfh5d4io	277	9	even	even	RB
cord-296585-yfh5d4io	277	10	further	far	RBR
cord-296585-yfh5d4io	277	11	,	,	,
cord-296585-yfh5d4io	277	12	and	and	CC
cord-296585-yfh5d4io	277	13	NTHi	NTHi	NNS
cord-296585-yfh5d4io	277	14	continues	continue	VBZ
cord-296585-yfh5d4io	277	15	to	to	TO
cord-296585-yfh5d4io	277	16	be	be	VB
cord-296585-yfh5d4io	277	17	the	the	DT
cord-296585-yfh5d4io	277	18	predominating	predominate	VBG
cord-296585-yfh5d4io	277	19	species	specie	NNS
cord-296585-yfh5d4io	277	20	(	(	-LRB-
cord-296585-yfh5d4io	277	21	208	208	CD
cord-296585-yfh5d4io	277	22	)	)	-RRB-
cord-296585-yfh5d4io	277	23	.	.	.
cord-296585-yfh5d4io	278	1	Furthermore	furthermore	RB
cord-296585-yfh5d4io	278	2	,	,	,
cord-296585-yfh5d4io	278	3	acquisition	acquisition	NN
cord-296585-yfh5d4io	278	4	of	of	IN
cord-296585-yfh5d4io	278	5	a	a	DT
cord-296585-yfh5d4io	278	6	new	new	JJ
cord-296585-yfh5d4io	278	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	278	8	strain	strain	NN
cord-296585-yfh5d4io	278	9	has	have	VBZ
cord-296585-yfh5d4io	278	10	,	,	,
cord-296585-yfh5d4io	278	11	in	in	IN
cord-296585-yfh5d4io	278	12	one	one	CD
cord-296585-yfh5d4io	278	13	study	study	NN
cord-296585-yfh5d4io	278	14	,	,	,
cord-296585-yfh5d4io	278	15	been	be	VBN
cord-296585-yfh5d4io	278	16	linked	link	VBN
cord-296585-yfh5d4io	278	17	to	to	IN
cord-296585-yfh5d4io	278	18	the	the	DT
cord-296585-yfh5d4io	278	19	onset	onset	NN
cord-296585-yfh5d4io	278	20	of	of	IN
cord-296585-yfh5d4io	278	21	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	278	22	(	(	-LRB-
cord-296585-yfh5d4io	278	23	153	153	CD
cord-296585-yfh5d4io	278	24	)	)	-RRB-
cord-296585-yfh5d4io	278	25	.	.	.
cord-296585-yfh5d4io	279	1	Moreover	moreover	RB
cord-296585-yfh5d4io	279	2	,	,	,
cord-296585-yfh5d4io	279	3	the	the	DT
cord-296585-yfh5d4io	279	4	growth	growth	NN
cord-296585-yfh5d4io	279	5	and	and	CC
cord-296585-yfh5d4io	279	6	dominance	dominance	NN
cord-296585-yfh5d4io	279	7	of	of	IN
cord-296585-yfh5d4io	279	8	H.	h.	NN
cord-296585-yfh5d4io	279	9	influenzae	influenzae	NN
cord-296585-yfh5d4io	279	10	following	follow	VBG
cord-296585-yfh5d4io	279	11	rhinovirus	rhinovirus	NN
cord-296585-yfh5d4io	279	12	infection	infection	NN
cord-296585-yfh5d4io	279	13	was	be	VBD
cord-296585-yfh5d4io	279	14	observed	observe	VBN
cord-296585-yfh5d4io	279	15	in	in	IN
cord-296585-yfh5d4io	279	16	the	the	DT
cord-296585-yfh5d4io	279	17	sputum	sputum	NN
cord-296585-yfh5d4io	279	18	microbiome	microbiome	NN
cord-296585-yfh5d4io	279	19	of	of	IN
cord-296585-yfh5d4io	279	20	patients	patient	NNS
cord-296585-yfh5d4io	279	21	with	with	IN
cord-296585-yfh5d4io	279	22	COPD	COPD	NNP
cord-296585-yfh5d4io	279	23	(	(	-LRB-
cord-296585-yfh5d4io	279	24	190	190	CD
cord-296585-yfh5d4io	279	25	)	)	-RRB-
cord-296585-yfh5d4io	279	26	.	.	.
cord-296585-yfh5d4io	280	1	The	the	DT
cord-296585-yfh5d4io	280	2	chronic	chronic	JJ
cord-296585-yfh5d4io	280	3	inflammation	inflammation	NN
cord-296585-yfh5d4io	280	4	that	that	WDT
cord-296585-yfh5d4io	280	5	characterizes	characterize	VBZ
cord-296585-yfh5d4io	280	6	COPD	COPD	NNP
cord-296585-yfh5d4io	280	7	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	280	8	causes	cause	VBZ
cord-296585-yfh5d4io	280	9	significant	significant	JJ
cord-296585-yfh5d4io	280	10	changes	change	NNS
cord-296585-yfh5d4io	280	11	to	to	IN
cord-296585-yfh5d4io	280	12	the	the	DT
cord-296585-yfh5d4io	280	13	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	280	14	tissue	tissue	NN
cord-296585-yfh5d4io	280	15	.	.	.
cord-296585-yfh5d4io	281	1	The	the	DT
cord-296585-yfh5d4io	281	2	lower	low	JJR
cord-296585-yfh5d4io	281	3	respiratory	respiratory	JJ
cord-296585-yfh5d4io	281	4	tract	tract	NN
cord-296585-yfh5d4io	281	5	of	of	IN
cord-296585-yfh5d4io	281	6	patients	patient	NNS
cord-296585-yfh5d4io	281	7	suffering	suffer	VBG
cord-296585-yfh5d4io	281	8	from	from	IN
cord-296585-yfh5d4io	281	9	this	this	DT
cord-296585-yfh5d4io	281	10	disease	disease	NN
cord-296585-yfh5d4io	281	11	is	be	VBZ
cord-296585-yfh5d4io	281	12	marked	mark	VBN
cord-296585-yfh5d4io	281	13	by	by	IN
cord-296585-yfh5d4io	281	14	epithelial	epithelial	JJ
cord-296585-yfh5d4io	281	15	denuding	denuding	NN
cord-296585-yfh5d4io	281	16	,	,	,
cord-296585-yfh5d4io	281	17	hypersecretion	hypersecretion	NN
cord-296585-yfh5d4io	281	18	of	of	IN
cord-296585-yfh5d4io	281	19	mucus	mucus	NN
cord-296585-yfh5d4io	281	20	,	,	,
cord-296585-yfh5d4io	281	21	disproportionate	disproportionate	JJ
cord-296585-yfh5d4io	281	22	phagocyte	phagocyte	NNS
cord-296585-yfh5d4io	281	23	presence	presence	NN
cord-296585-yfh5d4io	281	24	and	and	CC
cord-296585-yfh5d4io	281	25	imbalances	imbalance	NNS
cord-296585-yfh5d4io	281	26	in	in	IN
cord-296585-yfh5d4io	281	27	antioxidant	antioxidant	NN
cord-296585-yfh5d4io	281	28	/	/	SYM
cord-296585-yfh5d4io	281	29	oxidants	oxidant	NNS
cord-296585-yfh5d4io	281	30	(	(	-LRB-
cord-296585-yfh5d4io	281	31	220	220	CD
cord-296585-yfh5d4io	281	32	)	)	-RRB-
cord-296585-yfh5d4io	281	33	.	.	.
cord-296585-yfh5d4io	282	1	This	this	DT
cord-296585-yfh5d4io	282	2	altered	alter	VBN
cord-296585-yfh5d4io	282	3	milieu	milieu	NN
cord-296585-yfh5d4io	282	4	selects	select	VBZ
cord-296585-yfh5d4io	282	5	for	for	IN
cord-296585-yfh5d4io	282	6	specific	specific	JJ
cord-296585-yfh5d4io	282	7	bacterial	bacterial	JJ
cord-296585-yfh5d4io	282	8	species	specie	NNS
cord-296585-yfh5d4io	282	9	that	that	WDT
cord-296585-yfh5d4io	282	10	are	be	VBP
cord-296585-yfh5d4io	282	11	genetically	genetically	RB
cord-296585-yfh5d4io	282	12	equipped	equip	VBN
cord-296585-yfh5d4io	282	13	to	to	TO
cord-296585-yfh5d4io	282	14	competently	competently	RB
cord-296585-yfh5d4io	282	15	address	address	VB
cord-296585-yfh5d4io	282	16	these	these	DT
cord-296585-yfh5d4io	282	17	environmental	environmental	JJ
cord-296585-yfh5d4io	282	18	stressors	stressor	NNS
cord-296585-yfh5d4io	282	19	(	(	-LRB-
cord-296585-yfh5d4io	282	20	151	151	CD
cord-296585-yfh5d4io	282	21	,	,	,
cord-296585-yfh5d4io	282	22	195	195	CD
cord-296585-yfh5d4io	282	23	,	,	,
cord-296585-yfh5d4io	282	24	221	221	CD
cord-296585-yfh5d4io	282	25	)	)	-RRB-
cord-296585-yfh5d4io	282	26	.	.	.
cord-296585-yfh5d4io	283	1	NTHi	NTHi	NNP
cord-296585-yfh5d4io	283	2	is	be	VBZ
cord-296585-yfh5d4io	283	3	the	the	DT
cord-296585-yfh5d4io	283	4	most	most	RBS
cord-296585-yfh5d4io	283	5	common	common	JJ
cord-296585-yfh5d4io	283	6	pathogen	pathogen	NN
cord-296585-yfh5d4io	283	7	isolated	isolate	VBN
cord-296585-yfh5d4io	283	8	from	from	IN
cord-296585-yfh5d4io	283	9	the	the	DT
cord-296585-yfh5d4io	283	10	sputum	sputum	NN
cord-296585-yfh5d4io	283	11	of	of	IN
cord-296585-yfh5d4io	283	12	COPD	COPD	NNP
cord-296585-yfh5d4io	283	13	patients	patient	NNS
cord-296585-yfh5d4io	283	14	,	,	,
cord-296585-yfh5d4io	283	15	and	and	CC
cord-296585-yfh5d4io	283	16	the	the	DT
cord-296585-yfh5d4io	283	17	primary	primary	JJ
cord-296585-yfh5d4io	283	18	cause	cause	NN
cord-296585-yfh5d4io	283	19	of	of	IN
cord-296585-yfh5d4io	283	20	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	283	21	(	(	-LRB-
cord-296585-yfh5d4io	283	22	212	212	CD
cord-296585-yfh5d4io	283	23	)	)	-RRB-
cord-296585-yfh5d4io	283	24	,	,	,
cord-296585-yfh5d4io	283	25	indicating	indicate	VBG
cord-296585-yfh5d4io	283	26	a	a	DT
cord-296585-yfh5d4io	283	27	unique	unique	JJ
cord-296585-yfh5d4io	283	28	ability	ability	NN
cord-296585-yfh5d4io	283	29	to	to	TO
cord-296585-yfh5d4io	283	30	colonize	colonize	VB
cord-296585-yfh5d4io	283	31	and	and	CC
cord-296585-yfh5d4io	283	32	persist	persist	VB
cord-296585-yfh5d4io	283	33	in	in	IN
cord-296585-yfh5d4io	283	34	the	the	DT
cord-296585-yfh5d4io	283	35	chronically	chronically	RB
cord-296585-yfh5d4io	283	36	inflamed	inflamed	JJ
cord-296585-yfh5d4io	283	37	lower	low	JJR
cord-296585-yfh5d4io	283	38	respiratory	respiratory	JJ
cord-296585-yfh5d4io	283	39	tract	tract	NN
cord-296585-yfh5d4io	283	40	.	.	.
cord-296585-yfh5d4io	284	1	In	in	IN
cord-296585-yfh5d4io	284	2	recent	recent	JJ
cord-296585-yfh5d4io	284	3	years	year	NNS
cord-296585-yfh5d4io	284	4	,	,	,
cord-296585-yfh5d4io	284	5	great	great	JJ
cord-296585-yfh5d4io	284	6	efforts	effort	NNS
cord-296585-yfh5d4io	284	7	have	have	VBP
cord-296585-yfh5d4io	284	8	been	be	VBN
cord-296585-yfh5d4io	284	9	made	make	VBN
cord-296585-yfh5d4io	284	10	in	in	IN
cord-296585-yfh5d4io	284	11	understanding	understand	VBG
cord-296585-yfh5d4io	284	12	how	how	WRB
cord-296585-yfh5d4io	284	13	NTHi	NTHi	NNS
cord-296585-yfh5d4io	284	14	colonizes	colonize	VBZ
cord-296585-yfh5d4io	284	15	the	the	DT
cord-296585-yfh5d4io	284	16	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	284	17	tissue	tissue	NN
cord-296585-yfh5d4io	284	18	.	.	.
cord-296585-yfh5d4io	285	1	In	in	IN
cord-296585-yfh5d4io	285	2	addition	addition	NN
cord-296585-yfh5d4io	285	3	to	to	IN
cord-296585-yfh5d4io	285	4	the	the	DT
cord-296585-yfh5d4io	285	5	regular	regular	JJ
cord-296585-yfh5d4io	285	6	arsenal	arsenal	NN
cord-296585-yfh5d4io	285	7	of	of	IN
cord-296585-yfh5d4io	285	8	virulence	virulence	NN
cord-296585-yfh5d4io	285	9	factors	factor	NNS
cord-296585-yfh5d4io	285	10	associated	associate	VBN
cord-296585-yfh5d4io	285	11	with	with	IN
cord-296585-yfh5d4io	285	12	NTHi	NTHi	NNS
cord-296585-yfh5d4io	285	13	(	(	-LRB-
cord-296585-yfh5d4io	285	14	5	5	CD
cord-296585-yfh5d4io	285	15	)	)	-RRB-
cord-296585-yfh5d4io	285	16	,	,	,
cord-296585-yfh5d4io	285	17	the	the	DT
cord-296585-yfh5d4io	285	18	bacterial	bacterial	JJ
cord-296585-yfh5d4io	285	19	pathogen	pathogen	NN
cord-296585-yfh5d4io	285	20	undergoes	undergo	VBZ
cord-296585-yfh5d4io	285	21	specific	specific	JJ
cord-296585-yfh5d4io	285	22	adaptations	adaptation	NNS
cord-296585-yfh5d4io	285	23	to	to	TO
cord-296585-yfh5d4io	285	24	increase	increase	VB
cord-296585-yfh5d4io	285	25	its	-PRON-	PRP$
cord-296585-yfh5d4io	285	26	fitness	fitness	NN
cord-296585-yfh5d4io	285	27	in	in	IN
cord-296585-yfh5d4io	285	28	the	the	DT
cord-296585-yfh5d4io	285	29	COPD	COPD	NNP
cord-296585-yfh5d4io	285	30	setting	setting	NN
cord-296585-yfh5d4io	285	31	.	.	.
cord-296585-yfh5d4io	286	1	Specific	specific	JJ
cord-296585-yfh5d4io	286	2	genetic	genetic	JJ
cord-296585-yfh5d4io	286	3	islands	island	NNS
cord-296585-yfh5d4io	286	4	that	that	WDT
cord-296585-yfh5d4io	286	5	include	include	VBP
cord-296585-yfh5d4io	286	6	ureABCEFGH	ureABCEFGH	NNP
cord-296585-yfh5d4io	286	7	,	,	,
cord-296585-yfh5d4io	286	8	lic2b	lic2b	NNP
cord-296585-yfh5d4io	286	9	,	,	,
cord-296585-yfh5d4io	286	10	hgbA	hgba	CD
cord-296585-yfh5d4io	286	11	,	,	,
cord-296585-yfh5d4io	286	12	iga	iga	NNP
cord-296585-yfh5d4io	286	13	,	,	,
cord-296585-yfh5d4io	286	14	hmw1	hmw1	NNP
cord-296585-yfh5d4io	286	15	,	,	,
cord-296585-yfh5d4io	286	16	and	and	CC
cord-296585-yfh5d4io	286	17	hmw2	hmw2	PRP
cord-296585-yfh5d4io	286	18	have	have	VBP
cord-296585-yfh5d4io	286	19	been	be	VBN
cord-296585-yfh5d4io	286	20	reported	report	VBN
cord-296585-yfh5d4io	286	21	to	to	TO
cord-296585-yfh5d4io	286	22	be	be	VB
cord-296585-yfh5d4io	286	23	enriched	enrich	VBN
cord-296585-yfh5d4io	286	24	in	in	IN
cord-296585-yfh5d4io	286	25	NTHi	NTHi	NNS
cord-296585-yfh5d4io	286	26	strains	strain	NNS
cord-296585-yfh5d4io	286	27	isolated	isolate	VBN
cord-296585-yfh5d4io	286	28	from	from	IN
cord-296585-yfh5d4io	286	29	COPD	COPD	NNP
cord-296585-yfh5d4io	286	30	patients	patient	NNS
cord-296585-yfh5d4io	286	31	compared	compare	VBN
cord-296585-yfh5d4io	286	32	to	to	IN
cord-296585-yfh5d4io	286	33	commensal	commensal	JJ
cord-296585-yfh5d4io	286	34	NTHi	NTHi	NNS
cord-296585-yfh5d4io	286	35	(	(	-LRB-
cord-296585-yfh5d4io	286	36	222	222	CD
cord-296585-yfh5d4io	286	37	)	)	-RRB-
cord-296585-yfh5d4io	286	38	.	.	.
cord-296585-yfh5d4io	287	1	These	these	DT
cord-296585-yfh5d4io	287	2	genes	gene	NNS
cord-296585-yfh5d4io	287	3	are	be	VBP
cord-296585-yfh5d4io	287	4	involved	involve	VBN
cord-296585-yfh5d4io	287	5	in	in	IN
cord-296585-yfh5d4io	287	6	raising	raise	VBG
cord-296585-yfh5d4io	287	7	the	the	DT
cord-296585-yfh5d4io	287	8	pH	ph	NN
cord-296585-yfh5d4io	287	9	of	of	IN
cord-296585-yfh5d4io	287	10	the	the	DT
cord-296585-yfh5d4io	287	11	environment	environment	NN
cord-296585-yfh5d4io	287	12	,	,	,
cord-296585-yfh5d4io	287	13	lipooligosaccharide	lipooligosaccharide	NNP
cord-296585-yfh5d4io	287	14	(	(	-LRB-
cord-296585-yfh5d4io	287	15	LOS	LOS	NNP
cord-296585-yfh5d4io	287	16	)	)	-RRB-
cord-296585-yfh5d4io	287	17	synthesis	synthesis	NN
cord-296585-yfh5d4io	287	18	,	,	,
cord-296585-yfh5d4io	287	19	iron	iron	NN
cord-296585-yfh5d4io	287	20	uptake	uptake	NN
cord-296585-yfh5d4io	287	21	,	,	,
cord-296585-yfh5d4io	287	22	immune	immune	JJ
cord-296585-yfh5d4io	287	23	evasion	evasion	NN
cord-296585-yfh5d4io	287	24	,	,	,
cord-296585-yfh5d4io	287	25	and	and	CC
cord-296585-yfh5d4io	287	26	attachment	attachment	NN
cord-296585-yfh5d4io	287	27	to	to	TO
cord-296585-yfh5d4io	287	28	host	host	VB
cord-296585-yfh5d4io	287	29	tissue	tissue	NN
cord-296585-yfh5d4io	287	30	.	.	.
cord-296585-yfh5d4io	288	1	The	the	DT
cord-296585-yfh5d4io	288	2	validity	validity	NN
cord-296585-yfh5d4io	288	3	of	of	IN
cord-296585-yfh5d4io	288	4	these	these	DT
cord-296585-yfh5d4io	288	5	findings	finding	NNS
cord-296585-yfh5d4io	288	6	is	be	VBZ
cord-296585-yfh5d4io	288	7	strengthened	strengthen	VBN
cord-296585-yfh5d4io	288	8	by	by	IN
cord-296585-yfh5d4io	288	9	previous	previous	JJ
cord-296585-yfh5d4io	288	10	work	work	NN
cord-296585-yfh5d4io	288	11	identifying	identify	VBG
cord-296585-yfh5d4io	288	12	upregulation	upregulation	NN
cord-296585-yfh5d4io	288	13	of	of	IN
cord-296585-yfh5d4io	288	14	many	many	JJ
cord-296585-yfh5d4io	288	15	of	of	IN
cord-296585-yfh5d4io	288	16	the	the	DT
cord-296585-yfh5d4io	288	17	same	same	JJ
cord-296585-yfh5d4io	288	18	bacterial	bacterial	JJ
cord-296585-yfh5d4io	288	19	gene	gene	NN
cord-296585-yfh5d4io	288	20	products	product	NNS
cord-296585-yfh5d4io	288	21	during	during	IN
cord-296585-yfh5d4io	288	22	growth	growth	NN
cord-296585-yfh5d4io	288	23	in	in	IN
cord-296585-yfh5d4io	288	24	COPD	COPD	NNP
cord-296585-yfh5d4io	288	25	sputum	sputum	NN
cord-296585-yfh5d4io	288	26	(	(	-LRB-
cord-296585-yfh5d4io	288	27	223	223	CD
cord-296585-yfh5d4io	288	28	)	)	-RRB-
cord-296585-yfh5d4io	288	29	.	.	.
cord-296585-yfh5d4io	289	1	Moreover	moreover	RB
cord-296585-yfh5d4io	289	2	,	,	,
cord-296585-yfh5d4io	289	3	peroxiredoxinthioredoxin	peroxiredoxinthioredoxin	NNP
cord-296585-yfh5d4io	289	4	,	,	,
cord-296585-yfh5d4io	289	5	an	an	DT
cord-296585-yfh5d4io	289	6	antioxidant	antioxidant	JJ
cord-296585-yfh5d4io	289	7	enzyme	enzyme	NN
cord-296585-yfh5d4io	289	8	,	,	,
cord-296585-yfh5d4io	289	9	was	be	VBD
cord-296585-yfh5d4io	289	10	found	find	VBN
cord-296585-yfh5d4io	289	11	to	to	TO
cord-296585-yfh5d4io	289	12	be	be	VB
cord-296585-yfh5d4io	289	13	one	one	CD
cord-296585-yfh5d4io	289	14	of	of	IN
cord-296585-yfh5d4io	289	15	the	the	DT
cord-296585-yfh5d4io	289	16	most	most	RBS
cord-296585-yfh5d4io	289	17	enriched	enriched	JJ
cord-296585-yfh5d4io	289	18	proteins	protein	NNS
cord-296585-yfh5d4io	289	19	in	in	IN
cord-296585-yfh5d4io	289	20	NTHi	NTHi	NNS
cord-296585-yfh5d4io	289	21	during	during	IN
cord-296585-yfh5d4io	289	22	growth	growth	NN
cord-296585-yfh5d4io	289	23	in	in	IN
cord-296585-yfh5d4io	289	24	COPD	COPD	NNP
cord-296585-yfh5d4io	289	25	sputum	sputum	NN
cord-296585-yfh5d4io	289	26	,	,	,
cord-296585-yfh5d4io	289	27	suggesting	suggest	VBG
cord-296585-yfh5d4io	289	28	that	that	IN
cord-296585-yfh5d4io	289	29	the	the	DT
cord-296585-yfh5d4io	289	30	bacteria	bacteria	NNS
cord-296585-yfh5d4io	289	31	upregulate	upregulate	VBP
cord-296585-yfh5d4io	289	32	oxidative	oxidative	JJ
cord-296585-yfh5d4io	289	33	stress	stress	NN
cord-296585-yfh5d4io	289	34	-	-	HYPH
cord-296585-yfh5d4io	289	35	countermeasures	countermeasure	NNS
cord-296585-yfh5d4io	289	36	when	when	WRB
cord-296585-yfh5d4io	289	37	facing	face	VBG
cord-296585-yfh5d4io	289	38	oxidative	oxidative	JJ
cord-296585-yfh5d4io	289	39	imbalances	imbalance	NNS
cord-296585-yfh5d4io	289	40	in	in	IN
cord-296585-yfh5d4io	289	41	the	the	DT
cord-296585-yfh5d4io	289	42	diseased	diseased	JJ
cord-296585-yfh5d4io	289	43	lung	lung	NN
cord-296585-yfh5d4io	289	44	(	(	-LRB-
cord-296585-yfh5d4io	289	45	223	223	CD
cord-296585-yfh5d4io	289	46	)	)	-RRB-
cord-296585-yfh5d4io	289	47	.	.	.
cord-296585-yfh5d4io	290	1	Oxidative	oxidative	JJ
cord-296585-yfh5d4io	290	2	stress	stress	NN
cord-296585-yfh5d4io	290	3	resistance	resistance	NN
cord-296585-yfh5d4io	290	4	has	have	VBZ
cord-296585-yfh5d4io	290	5	previously	previously	RB
cord-296585-yfh5d4io	290	6	been	be	VBN
cord-296585-yfh5d4io	290	7	shown	show	VBN
cord-296585-yfh5d4io	290	8	to	to	TO
cord-296585-yfh5d4io	290	9	be	be	VB
cord-296585-yfh5d4io	290	10	vital	vital	JJ
cord-296585-yfh5d4io	290	11	for	for	IN
cord-296585-yfh5d4io	290	12	NTHi	nthi	JJ
cord-296585-yfh5d4io	290	13	survival	survival	NN
cord-296585-yfh5d4io	290	14	in	in	IN
cord-296585-yfh5d4io	290	15	infection	infection	NN
cord-296585-yfh5d4io	290	16	models	model	NNS
cord-296585-yfh5d4io	290	17	(	(	-LRB-
cord-296585-yfh5d4io	290	18	224	224	CD
cord-296585-yfh5d4io	290	19	)	)	-RRB-
cord-296585-yfh5d4io	290	20	.	.	.
cord-296585-yfh5d4io	291	1	In	in	IN
cord-296585-yfh5d4io	291	2	a	a	DT
cord-296585-yfh5d4io	291	3	seminal	seminal	JJ
cord-296585-yfh5d4io	291	4	investigation	investigation	NN
cord-296585-yfh5d4io	291	5	by	by	IN
cord-296585-yfh5d4io	291	6	Pettigrew	Pettigrew	NNP
cord-296585-yfh5d4io	291	7	et	et	NNP
cord-296585-yfh5d4io	291	8	al	al	NNP
cord-296585-yfh5d4io	291	9	.	.	.
cord-296585-yfh5d4io	292	1	,	,	,
cord-296585-yfh5d4io	292	2	wholegenome	wholegenome	NNP
cord-296585-yfh5d4io	292	3	sequencing	sequencing	NN
cord-296585-yfh5d4io	292	4	(	(	-LRB-
cord-296585-yfh5d4io	292	5	WGS	WGS	NNP
cord-296585-yfh5d4io	292	6	)	)	-RRB-
cord-296585-yfh5d4io	292	7	was	be	VBD
cord-296585-yfh5d4io	292	8	conducted	conduct	VBN
cord-296585-yfh5d4io	292	9	to	to	TO
cord-296585-yfh5d4io	292	10	follow	follow	VB
cord-296585-yfh5d4io	292	11	the	the	DT
cord-296585-yfh5d4io	292	12	in	in	IN
cord-296585-yfh5d4io	292	13	vivo	vivo	NN
cord-296585-yfh5d4io	292	14	adaptation	adaptation	NN
cord-296585-yfh5d4io	292	15	of	of	IN
cord-296585-yfh5d4io	292	16	NTHi	NTHi	NNS
cord-296585-yfh5d4io	292	17	to	to	IN
cord-296585-yfh5d4io	292	18	the	the	DT
cord-296585-yfh5d4io	292	19	COPD	COPD	NNP
cord-296585-yfh5d4io	292	20	environment	environment	NN
cord-296585-yfh5d4io	292	21	over	over	IN
cord-296585-yfh5d4io	292	22	time	time	NN
cord-296585-yfh5d4io	292	23	(	(	-LRB-
cord-296585-yfh5d4io	292	24	225	225	CD
cord-296585-yfh5d4io	292	25	)	)	-RRB-
cord-296585-yfh5d4io	292	26	.	.	.
cord-296585-yfh5d4io	293	1	Several	several	JJ
cord-296585-yfh5d4io	293	2	interesting	interesting	JJ
cord-296585-yfh5d4io	293	3	findings	finding	NNS
cord-296585-yfh5d4io	293	4	were	be	VBD
cord-296585-yfh5d4io	293	5	reported	report	VBN
cord-296585-yfh5d4io	293	6	in	in	IN
cord-296585-yfh5d4io	293	7	this	this	DT
cord-296585-yfh5d4io	293	8	work	work	NN
cord-296585-yfh5d4io	293	9	.	.	.
cord-296585-yfh5d4io	294	1	Firstly	firstly	RB
cord-296585-yfh5d4io	294	2	,	,	,
cord-296585-yfh5d4io	294	3	the	the	DT
cord-296585-yfh5d4io	294	4	median	median	JJ
cord-296585-yfh5d4io	294	5	duration	duration	NN
cord-296585-yfh5d4io	294	6	of	of	IN
cord-296585-yfh5d4io	294	7	persistence	persistence	NN
cord-296585-yfh5d4io	294	8	by	by	IN
cord-296585-yfh5d4io	294	9	the	the	DT
cord-296585-yfh5d4io	294	10	pathogen	pathogen	NN
cord-296585-yfh5d4io	294	11	was	be	VBD
cord-296585-yfh5d4io	294	12	found	find	VBN
cord-296585-yfh5d4io	294	13	to	to	TO
cord-296585-yfh5d4io	294	14	be	be	VB
cord-296585-yfh5d4io	294	15	161	161	CD
cord-296585-yfh5d4io	294	16	days	day	NNS
cord-296585-yfh5d4io	294	17	,	,	,
cord-296585-yfh5d4io	294	18	but	but	CC
cord-296585-yfh5d4io	294	19	it	-PRON-	PRP
cord-296585-yfh5d4io	294	20	could	could	MD
cord-296585-yfh5d4io	294	21	persist	persist	VB
cord-296585-yfh5d4io	294	22	in	in	IN
cord-296585-yfh5d4io	294	23	patients	patient	NNS
cord-296585-yfh5d4io	294	24	for	for	IN
cord-296585-yfh5d4io	294	25	up	up	IN
cord-296585-yfh5d4io	294	26	to	to	TO
cord-296585-yfh5d4io	294	27	as	as	RB
cord-296585-yfh5d4io	294	28	many	many	JJ
cord-296585-yfh5d4io	294	29	as	as	IN
cord-296585-yfh5d4io	294	30	1,422	1,422	CD
cord-296585-yfh5d4io	294	31	days	day	NNS
cord-296585-yfh5d4io	294	32	.	.	.
cord-296585-yfh5d4io	295	1	Secondly	secondly	RB
cord-296585-yfh5d4io	295	2	,	,	,
cord-296585-yfh5d4io	295	3	slipped	slip	VBN
cord-296585-yfh5d4io	295	4	-	-	HYPH
cord-296585-yfh5d4io	295	5	strand	strand	NN
cord-296585-yfh5d4io	295	6	mispairing	mispairing	NN
cord-296585-yfh5d4io	295	7	-	-	HYPH
cord-296585-yfh5d4io	295	8	mediated	mediate	VBN
cord-296585-yfh5d4io	295	9	phase	phase	NN
cord-296585-yfh5d4io	295	10	variation	variation	NN
cord-296585-yfh5d4io	295	11	was	be	VBD
cord-296585-yfh5d4io	295	12	identified	identify	VBN
cord-296585-yfh5d4io	295	13	as	as	IN
cord-296585-yfh5d4io	295	14	the	the	DT
cord-296585-yfh5d4io	295	15	primary	primary	JJ
cord-296585-yfh5d4io	295	16	genetic	genetic	JJ
cord-296585-yfh5d4io	295	17	adaptation	adaptation	NN
cord-296585-yfh5d4io	295	18	to	to	IN
cord-296585-yfh5d4io	295	19	the	the	DT
cord-296585-yfh5d4io	295	20	niche	niche	NN
cord-296585-yfh5d4io	295	21	.	.	.
cord-296585-yfh5d4io	296	1	Poignantly	poignantly	RB
cord-296585-yfh5d4io	296	2	,	,	,
cord-296585-yfh5d4io	296	3	the	the	DT
cord-296585-yfh5d4io	296	4	genes	gene	NNS
cord-296585-yfh5d4io	296	5	affected	affect	VBN
cord-296585-yfh5d4io	296	6	by	by	IN
cord-296585-yfh5d4io	296	7	the	the	DT
cord-296585-yfh5d4io	296	8	regulation	regulation	NN
cord-296585-yfh5d4io	296	9	mechanism	mechanism	NN
cord-296585-yfh5d4io	296	10	encoded	encode	VBN
cord-296585-yfh5d4io	296	11	for	for	IN
cord-296585-yfh5d4io	296	12	(	(	-LRB-
cord-296585-yfh5d4io	296	13	among	among	IN
cord-296585-yfh5d4io	296	14	others	other	NNS
cord-296585-yfh5d4io	296	15	)	)	-RRB-
cord-296585-yfh5d4io	296	16	the	the	DT
cord-296585-yfh5d4io	296	17	HMW	HMW	NNP
cord-296585-yfh5d4io	296	18	adhesins	adhesin	NNS
cord-296585-yfh5d4io	296	19	,	,	,
cord-296585-yfh5d4io	296	20	LOS	LOS	NNP
cord-296585-yfh5d4io	296	21	biosynthesis	biosynthesis	NN
cord-296585-yfh5d4io	296	22	,	,	,
cord-296585-yfh5d4io	296	23	and	and	CC
cord-296585-yfh5d4io	296	24	iron	iron	NN
cord-296585-yfh5d4io	296	25	uptake	uptake	NN
cord-296585-yfh5d4io	296	26	,	,	,
cord-296585-yfh5d4io	296	27	that	that	RB
cord-296585-yfh5d4io	296	28	is	is	RB
cord-296585-yfh5d4io	296	29	,	,	,
cord-296585-yfh5d4io	296	30	the	the	DT
cord-296585-yfh5d4io	296	31	same	same	JJ
cord-296585-yfh5d4io	296	32	processes	process	NNS
cord-296585-yfh5d4io	296	33	identified	identify	VBN
cord-296585-yfh5d4io	296	34	in	in	IN
cord-296585-yfh5d4io	296	35	the	the	DT
cord-296585-yfh5d4io	296	36	previous	previous	JJ
cord-296585-yfh5d4io	296	37	studies	study	NNS
cord-296585-yfh5d4io	296	38	as	as	IN
cord-296585-yfh5d4io	296	39	important	important	JJ
cord-296585-yfh5d4io	296	40	for	for	IN
cord-296585-yfh5d4io	296	41	COPD	COPD	NNP
cord-296585-yfh5d4io	296	42	adaptation	adaptation	NN
cord-296585-yfh5d4io	296	43	(	(	-LRB-
cord-296585-yfh5d4io	296	44	222	222	CD
cord-296585-yfh5d4io	296	45	,	,	,
cord-296585-yfh5d4io	296	46	223	223	CD
cord-296585-yfh5d4io	296	47	)	)	-RRB-
cord-296585-yfh5d4io	296	48	.	.	.
cord-296585-yfh5d4io	297	1	Thirdly	thirdly	RB
cord-296585-yfh5d4io	297	2	,	,	,
cord-296585-yfh5d4io	297	3	and	and	CC
cord-296585-yfh5d4io	297	4	somewhat	somewhat	RB
cord-296585-yfh5d4io	297	5	surprising	surprising	JJ
cord-296585-yfh5d4io	297	6	,	,	,
cord-296585-yfh5d4io	297	7	it	-PRON-	PRP
cord-296585-yfh5d4io	297	8	was	be	VBD
cord-296585-yfh5d4io	297	9	observed	observe	VBN
cord-296585-yfh5d4io	297	10	that	that	IN
cord-296585-yfh5d4io	297	11	a	a	DT
cord-296585-yfh5d4io	297	12	very	very	RB
cord-296585-yfh5d4io	297	13	limited	limited	JJ
cord-296585-yfh5d4io	297	14	number	number	NN
cord-296585-yfh5d4io	297	15	of	of	IN
cord-296585-yfh5d4io	297	16	genes	gene	NNS
cord-296585-yfh5d4io	297	17	were	be	VBD
cord-296585-yfh5d4io	297	18	gained	gain	VBN
cord-296585-yfh5d4io	297	19	/	/	SYM
cord-296585-yfh5d4io	297	20	lost	lose	VBN
cord-296585-yfh5d4io	297	21	during	during	IN
cord-296585-yfh5d4io	297	22	persistent	persistent	JJ
cord-296585-yfh5d4io	297	23	colonization	colonization	NN
cord-296585-yfh5d4io	297	24	,	,	,
cord-296585-yfh5d4io	297	25	meaning	mean	VBG
cord-296585-yfh5d4io	297	26	that	that	IN
cord-296585-yfh5d4io	297	27	selection	selection	NN
cord-296585-yfh5d4io	297	28	for	for	IN
cord-296585-yfh5d4io	297	29	strains	strain	NNS
cord-296585-yfh5d4io	297	30	that	that	WDT
cord-296585-yfh5d4io	297	31	thrive	thrive	VBP
cord-296585-yfh5d4io	297	32	in	in	IN
cord-296585-yfh5d4io	297	33	the	the	DT
cord-296585-yfh5d4io	297	34	inflamed	inflamed	JJ
cord-296585-yfh5d4io	297	35	lower	low	JJR
cord-296585-yfh5d4io	297	36	airways	airway	NNS
cord-296585-yfh5d4io	297	37	occurs	occur	VBZ
cord-296585-yfh5d4io	297	38	at	at	IN
cord-296585-yfh5d4io	297	39	the	the	DT
cord-296585-yfh5d4io	297	40	very	very	JJ
cord-296585-yfh5d4io	297	41	onset	onset	NN
cord-296585-yfh5d4io	297	42	of	of	IN
cord-296585-yfh5d4io	297	43	colonization	colonization	NN
cord-296585-yfh5d4io	297	44	.	.	.
cord-296585-yfh5d4io	298	1	Finally	finally	RB
cord-296585-yfh5d4io	298	2	,	,	,
cord-296585-yfh5d4io	298	3	the	the	DT
cord-296585-yfh5d4io	298	4	authors	author	NNS
cord-296585-yfh5d4io	298	5	reported	report	VBD
cord-296585-yfh5d4io	298	6	that	that	IN
cord-296585-yfh5d4io	298	7	genetic	genetic	JJ
cord-296585-yfh5d4io	298	8	changes	change	NNS
cord-296585-yfh5d4io	298	9	occurred	occur	VBD
cord-296585-yfh5d4io	298	10	in	in	IN
cord-296585-yfh5d4io	298	11	8	8	CD
cord-296585-yfh5d4io	298	12	of	of	IN
cord-296585-yfh5d4io	298	13	the	the	DT
cord-296585-yfh5d4io	298	14	12	12	CD
cord-296585-yfh5d4io	298	15	investigated	investigate	VBN
cord-296585-yfh5d4io	298	16	vaccine	vaccine	NN
cord-296585-yfh5d4io	298	17	antigens	antigen	NNS
cord-296585-yfh5d4io	298	18	during	during	IN
cord-296585-yfh5d4io	298	19	persistent	persistent	JJ
cord-296585-yfh5d4io	298	20	infections	infection	NNS
cord-296585-yfh5d4io	298	21	,	,	,
cord-296585-yfh5d4io	298	22	a	a	DT
cord-296585-yfh5d4io	298	23	fact	fact	NN
cord-296585-yfh5d4io	298	24	that	that	WDT
cord-296585-yfh5d4io	298	25	might	may	MD
cord-296585-yfh5d4io	298	26	be	be	VB
cord-296585-yfh5d4io	298	27	taken	take	VBN
cord-296585-yfh5d4io	298	28	into	into	IN
cord-296585-yfh5d4io	298	29	consideration	consideration	NN
cord-296585-yfh5d4io	298	30	for	for	IN
cord-296585-yfh5d4io	298	31	potential	potential	JJ
cord-296585-yfh5d4io	298	32	vaccine	vaccine	NN
cord-296585-yfh5d4io	298	33	development	development	NN
cord-296585-yfh5d4io	298	34	against	against	IN
cord-296585-yfh5d4io	298	35	NTHi	NTHi	NNS
cord-296585-yfh5d4io	298	36	.	.	.
cord-296585-yfh5d4io	299	1	Another	another	DT
cord-296585-yfh5d4io	299	2	virulence	virulence	NN
cord-296585-yfh5d4io	299	3	factor	factor	NN
cord-296585-yfh5d4io	299	4	that	that	WDT
cord-296585-yfh5d4io	299	5	has	have	VBZ
cord-296585-yfh5d4io	299	6	been	be	VBN
cord-296585-yfh5d4io	299	7	reported	report	VBN
cord-296585-yfh5d4io	299	8	by	by	IN
cord-296585-yfh5d4io	299	9	Murphy	Murphy	NNP
cord-296585-yfh5d4io	299	10	and	and	CC
cord-296585-yfh5d4io	299	11	co	co	NNS
cord-296585-yfh5d4io	299	12	-	-	NNS
cord-296585-yfh5d4io	299	13	workers	worker	NNS
cord-296585-yfh5d4io	299	14	to	to	TO
cord-296585-yfh5d4io	299	15	play	play	VB
cord-296585-yfh5d4io	299	16	a	a	DT
cord-296585-yfh5d4io	299	17	pivotal	pivotal	JJ
cord-296585-yfh5d4io	299	18	role	role	NN
cord-296585-yfh5d4io	299	19	for	for	IN
cord-296585-yfh5d4io	299	20	NTHi	NTHi	NNP
cord-296585-yfh5d4io	299	21	survival	survival	NN
cord-296585-yfh5d4io	299	22	in	in	IN
cord-296585-yfh5d4io	299	23	COPD	COPD	NNP
cord-296585-yfh5d4io	299	24	settings	setting	NNS
cord-296585-yfh5d4io	299	25	is	be	VBZ
cord-296585-yfh5d4io	299	26	IgA	iga	NN
cord-296585-yfh5d4io	299	27	-	-	HYPH
cord-296585-yfh5d4io	299	28	protease	protease	NNP
cord-296585-yfh5d4io	299	29	,	,	,
cord-296585-yfh5d4io	299	30	a	a	DT
cord-296585-yfh5d4io	299	31	hydrolytic	hydrolytic	JJ
cord-296585-yfh5d4io	299	32	enzyme	enzyme	NN
cord-296585-yfh5d4io	299	33	that	that	WDT
cord-296585-yfh5d4io	299	34	cleaves	cleave	VBZ
cord-296585-yfh5d4io	299	35	secretory	secretory	JJ
cord-296585-yfh5d4io	299	36	IgA	IgA	NNP
cord-296585-yfh5d4io	299	37	(	(	-LRB-
cord-296585-yfh5d4io	299	38	sIgA	sIgA	NNP
cord-296585-yfh5d4io	299	39	)	)	-RRB-
cord-296585-yfh5d4io	299	40	antibodies	antibody	NNS
cord-296585-yfh5d4io	299	41	in	in	IN
cord-296585-yfh5d4io	299	42	the	the	DT
cord-296585-yfh5d4io	299	43	mucosal	mucosal	JJ
cord-296585-yfh5d4io	299	44	epithelium	epithelium	NN
cord-296585-yfh5d4io	299	45	(	(	-LRB-
cord-296585-yfh5d4io	299	46	226	226	CD
cord-296585-yfh5d4io	299	47	)	)	-RRB-
cord-296585-yfh5d4io	299	48	(	(	-LRB-
cord-296585-yfh5d4io	299	49	227	227	CD
cord-296585-yfh5d4io	299	50	)	)	-RRB-
cord-296585-yfh5d4io	299	51	(	(	-LRB-
cord-296585-yfh5d4io	299	52	228	228	CD
cord-296585-yfh5d4io	299	53	)	)	-RRB-
cord-296585-yfh5d4io	299	54	.	.	.
cord-296585-yfh5d4io	300	1	Four	four	CD
cord-296585-yfh5d4io	300	2	genes	gene	NNS
cord-296585-yfh5d4io	300	3	encode	encode	VBP
cord-296585-yfh5d4io	300	4	for	for	IN
cord-296585-yfh5d4io	300	5	the	the	DT
cord-296585-yfh5d4io	300	6	same	same	JJ
cord-296585-yfh5d4io	300	7	number	number	NN
cord-296585-yfh5d4io	300	8	of	of	IN
cord-296585-yfh5d4io	300	9	different	different	JJ
cord-296585-yfh5d4io	300	10	variants	variant	NNS
cord-296585-yfh5d4io	300	11	of	of	IN
cord-296585-yfh5d4io	300	12	the	the	DT
cord-296585-yfh5d4io	300	13	endopeptidase	endopeptidase	NN
cord-296585-yfh5d4io	300	14	with	with	IN
cord-296585-yfh5d4io	300	15	various	various	JJ
cord-296585-yfh5d4io	300	16	cleavage	cleavage	NN
cord-296585-yfh5d4io	300	17	site	site	NN
cord-296585-yfh5d4io	300	18	specificities	specificity	NNS
cord-296585-yfh5d4io	300	19	:	:	:
cord-296585-yfh5d4io	301	1	two	two	CD
cord-296585-yfh5d4io	301	2	igaA	igaA	.
cord-296585-yfh5d4io	302	1	(	(	-LRB-
cord-296585-yfh5d4io	302	2	igaA1	igaa1	NN
cord-296585-yfh5d4io	302	3	and	and	CC
cord-296585-yfh5d4io	302	4	igaA2	igaa2	ADD
cord-296585-yfh5d4io	302	5	)	)	-RRB-
cord-296585-yfh5d4io	303	1	and	and	CC
cord-296585-yfh5d4io	303	2	two	two	CD
cord-296585-yfh5d4io	303	3	igaB	igaB	.
cord-296585-yfh5d4io	304	1	(	(	-LRB-
cord-296585-yfh5d4io	304	2	igaB1	igaB1	NFP
cord-296585-yfh5d4io	305	1	and	and	CC
cord-296585-yfh5d4io	305	2	igaB2	igab2	ADD
cord-296585-yfh5d4io	305	3	)	)	-RRB-
cord-296585-yfh5d4io	305	4	.	.	.
cord-296585-yfh5d4io	306	1	The	the	DT
cord-296585-yfh5d4io	306	2	igaA	igaa	JJ
cord-296585-yfh5d4io	306	3	is	be	VBZ
cord-296585-yfh5d4io	306	4	present	present	JJ
cord-296585-yfh5d4io	306	5	in	in	IN
cord-296585-yfh5d4io	306	6	all	all	DT
cord-296585-yfh5d4io	306	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	306	8	whereas	whereas	IN
cord-296585-yfh5d4io	306	9	igaB	igaB	NNP
cord-296585-yfh5d4io	306	10	is	be	VBZ
cord-296585-yfh5d4io	306	11	present	present	JJ
cord-296585-yfh5d4io	306	12	in	in	IN
cord-296585-yfh5d4io	306	13	∼40	∼40	NN
cord-296585-yfh5d4io	306	14	%	%	NN
cord-296585-yfh5d4io	306	15	of	of	IN
cord-296585-yfh5d4io	306	16	the	the	DT
cord-296585-yfh5d4io	306	17	strains	strain	NNS
cord-296585-yfh5d4io	306	18	(	(	-LRB-
cord-296585-yfh5d4io	306	19	226	226	CD
cord-296585-yfh5d4io	306	20	)	)	-RRB-
cord-296585-yfh5d4io	306	21	.	.	.
cord-296585-yfh5d4io	307	1	The	the	DT
cord-296585-yfh5d4io	307	2	igaB1	igab1	NN
cord-296585-yfh5d4io	307	3	gene	gene	NN
cord-296585-yfh5d4io	307	4	has	have	VBZ
cord-296585-yfh5d4io	307	5	been	be	VBN
cord-296585-yfh5d4io	307	6	reported	report	VBN
cord-296585-yfh5d4io	307	7	to	to	TO
cord-296585-yfh5d4io	307	8	be	be	VB
cord-296585-yfh5d4io	307	9	more	more	RBR
cord-296585-yfh5d4io	307	10	prevalent	prevalent	JJ
cord-296585-yfh5d4io	307	11	in	in	IN
cord-296585-yfh5d4io	307	12	COPD	COPD	NNP
cord-296585-yfh5d4io	307	13	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	307	14	-	-	HYPH
cord-296585-yfh5d4io	307	15	causing	cause	VBG
cord-296585-yfh5d4io	307	16	strains	strain	NNS
cord-296585-yfh5d4io	307	17	,	,	,
cord-296585-yfh5d4io	307	18	although	although	IN
cord-296585-yfh5d4io	307	19	the	the	DT
cord-296585-yfh5d4io	307	20	in	in	IN
cord-296585-yfh5d4io	307	21	vivo	vivo	NN
cord-296585-yfh5d4io	307	22	expression	expression	NN
cord-296585-yfh5d4io	307	23	levels	level	NNS
cord-296585-yfh5d4io	307	24	did	do	VBD
cord-296585-yfh5d4io	307	25	not	not	RB
cord-296585-yfh5d4io	307	26	differ	differ	VB
cord-296585-yfh5d4io	307	27	from	from	IN
cord-296585-yfh5d4io	307	28	asymptomatic	asymptomatic	JJ
cord-296585-yfh5d4io	307	29	colonization	colonization	NN
cord-296585-yfh5d4io	307	30	strains	strain	NNS
cord-296585-yfh5d4io	307	31	that	that	WDT
cord-296585-yfh5d4io	307	32	also	also	RB
cord-296585-yfh5d4io	307	33	carried	carry	VBD
cord-296585-yfh5d4io	307	34	the	the	DT
cord-296585-yfh5d4io	307	35	gene	gene	NN
cord-296585-yfh5d4io	307	36	(	(	-LRB-
cord-296585-yfh5d4io	307	37	226	226	CD
cord-296585-yfh5d4io	307	38	)	)	-RRB-
cord-296585-yfh5d4io	307	39	.	.	.
cord-296585-yfh5d4io	308	1	However	however	RB
cord-296585-yfh5d4io	308	2	,	,	,
cord-296585-yfh5d4io	308	3	IgA	iga	NN
cord-296585-yfh5d4io	308	4	-	-	HYPH
cord-296585-yfh5d4io	308	5	protease	protease	NN
cord-296585-yfh5d4io	308	6	B1	b1	NN
cord-296585-yfh5d4io	308	7	and	and	CC
cord-296585-yfh5d4io	308	8	B2	b2	NN
cord-296585-yfh5d4io	308	9	have	have	VBP
cord-296585-yfh5d4io	308	10	been	be	VBN
cord-296585-yfh5d4io	308	11	found	find	VBN
cord-296585-yfh5d4io	308	12	to	to	TO
cord-296585-yfh5d4io	308	13	promote	promote	VB
cord-296585-yfh5d4io	308	14	the	the	DT
cord-296585-yfh5d4io	308	15	intracellular	intracellular	JJ
cord-296585-yfh5d4io	308	16	survival	survival	NN
cord-296585-yfh5d4io	308	17	of	of	IN
cord-296585-yfh5d4io	308	18	NTHi	NTHi	NNS
cord-296585-yfh5d4io	308	19	in	in	IN
cord-296585-yfh5d4io	308	20	human	human	JJ
cord-296585-yfh5d4io	308	21	epithelial	epithelial	JJ
cord-296585-yfh5d4io	308	22	cells	cell	NNS
cord-296585-yfh5d4io	308	23	,	,	,
cord-296585-yfh5d4io	308	24	providing	provide	VBG
cord-296585-yfh5d4io	308	25	a	a	DT
cord-296585-yfh5d4io	308	26	secondary	secondary	JJ
cord-296585-yfh5d4io	308	27	function	function	NN
cord-296585-yfh5d4io	308	28	(	(	-LRB-
cord-296585-yfh5d4io	308	29	in	in	IN
cord-296585-yfh5d4io	308	30	addition	addition	NN
cord-296585-yfh5d4io	308	31	to	to	IN
cord-296585-yfh5d4io	308	32	hydrolysis	hydrolysis	NN
cord-296585-yfh5d4io	308	33	of	of	IN
cord-296585-yfh5d4io	308	34	IgA	IgA	NNP
cord-296585-yfh5d4io	308	35	antibodies	antibody	NNS
cord-296585-yfh5d4io	308	36	)	)	-RRB-
cord-296585-yfh5d4io	308	37	that	that	WDT
cord-296585-yfh5d4io	308	38	could	could	MD
cord-296585-yfh5d4io	308	39	facilitate	facilitate	VB
cord-296585-yfh5d4io	308	40	NTHi	nthi	JJ
cord-296585-yfh5d4io	308	41	growth	growth	NN
cord-296585-yfh5d4io	308	42	in	in	IN
cord-296585-yfh5d4io	308	43	inflamed	inflamed	JJ
cord-296585-yfh5d4io	308	44	environments	environment	NNS
cord-296585-yfh5d4io	308	45	(	(	-LRB-
cord-296585-yfh5d4io	308	46	227	227	CD
cord-296585-yfh5d4io	308	47	)	)	-RRB-
cord-296585-yfh5d4io	308	48	.	.	.
cord-296585-yfh5d4io	309	1	While	while	IN
cord-296585-yfh5d4io	309	2	a	a	DT
cord-296585-yfh5d4io	309	3	majority	majority	NN
cord-296585-yfh5d4io	309	4	of	of	IN
cord-296585-yfh5d4io	309	5	the	the	DT
cord-296585-yfh5d4io	309	6	persistent	persistent	JJ
cord-296585-yfh5d4io	309	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	309	8	strains	strain	NNS
cord-296585-yfh5d4io	309	9	that	that	WDT
cord-296585-yfh5d4io	309	10	dwell	dwell	VBP
cord-296585-yfh5d4io	309	11	in	in	IN
cord-296585-yfh5d4io	309	12	COPD	COPD	NNP
cord-296585-yfh5d4io	309	13	patients	patient	NNS
cord-296585-yfh5d4io	309	14	continuously	continuously	RB
cord-296585-yfh5d4io	309	15	express	express	VBP
cord-296585-yfh5d4io	309	16	one	one	CD
cord-296585-yfh5d4io	309	17	or	or	CC
cord-296585-yfh5d4io	309	18	more	more	JJR
cord-296585-yfh5d4io	309	19	variants	variant	NNS
cord-296585-yfh5d4io	309	20	of	of	IN
cord-296585-yfh5d4io	309	21	the	the	DT
cord-296585-yfh5d4io	309	22	enzyme	enzyme	NN
cord-296585-yfh5d4io	309	23	,	,	,
cord-296585-yfh5d4io	309	24	it	-PRON-	PRP
cord-296585-yfh5d4io	309	25	has	have	VBZ
cord-296585-yfh5d4io	309	26	recently	recently	RB
cord-296585-yfh5d4io	309	27	been	be	VBN
cord-296585-yfh5d4io	309	28	found	find	VBN
cord-296585-yfh5d4io	309	29	that	that	IN
cord-296585-yfh5d4io	309	30	a	a	DT
cord-296585-yfh5d4io	309	31	phase	phase	NN
cord-296585-yfh5d4io	309	32	variation	variation	NN
cord-296585-yfh5d4io	309	33	to	to	IN
cord-296585-yfh5d4io	309	34	an	an	DT
cord-296585-yfh5d4io	309	35	OFF	off	JJ
cord-296585-yfh5d4io	309	36	-	-	HYPH
cord-296585-yfh5d4io	309	37	state	state	NN
cord-296585-yfh5d4io	309	38	can	can	MD
cord-296585-yfh5d4io	309	39	occur	occur	VB
cord-296585-yfh5d4io	309	40	via	via	IN
cord-296585-yfh5d4io	309	41	slipped	slip	VBN
cord-296585-yfh5d4io	309	42	-	-	HYPH
cord-296585-yfh5d4io	309	43	strand	strand	NN
cord-296585-yfh5d4io	309	44	mispairing	mispairing	NN
cord-296585-yfh5d4io	309	45	over	over	IN
cord-296585-yfh5d4io	309	46	time	time	NN
cord-296585-yfh5d4io	309	47	(	(	-LRB-
cord-296585-yfh5d4io	309	48	228	228	CD
cord-296585-yfh5d4io	309	49	)	)	-RRB-
cord-296585-yfh5d4io	309	50	.	.	.
cord-296585-yfh5d4io	310	1	This	this	DT
cord-296585-yfh5d4io	310	2	suggests	suggest	VBZ
cord-296585-yfh5d4io	310	3	that	that	IN
cord-296585-yfh5d4io	310	4	during	during	IN
cord-296585-yfh5d4io	310	5	certain	certain	JJ
cord-296585-yfh5d4io	310	6	conditions	condition	NNS
cord-296585-yfh5d4io	310	7	,	,	,
cord-296585-yfh5d4io	310	8	there	there	EX
cord-296585-yfh5d4io	310	9	is	be	VBZ
cord-296585-yfh5d4io	310	10	a	a	DT
cord-296585-yfh5d4io	310	11	fitness	fitness	NN
cord-296585-yfh5d4io	310	12	benefit	benefit	NN
cord-296585-yfh5d4io	310	13	in	in	IN
cord-296585-yfh5d4io	310	14	not	not	RB
cord-296585-yfh5d4io	310	15	expressing	express	VBG
cord-296585-yfh5d4io	310	16	iga	iga	NNP
cord-296585-yfh5d4io	310	17	in	in	IN
cord-296585-yfh5d4io	310	18	the	the	DT
cord-296585-yfh5d4io	310	19	airways	airways	NNPS
cord-296585-yfh5d4io	310	20	of	of	IN
cord-296585-yfh5d4io	310	21	COPD	COPD	NNP
cord-296585-yfh5d4io	310	22	patients	patient	NNS
cord-296585-yfh5d4io	310	23	,	,	,
cord-296585-yfh5d4io	310	24	albeit	albeit	IN
cord-296585-yfh5d4io	310	25	the	the	DT
cord-296585-yfh5d4io	310	26	specifics	specific	NNS
cord-296585-yfh5d4io	310	27	of	of	IN
cord-296585-yfh5d4io	310	28	this	this	DT
cord-296585-yfh5d4io	310	29	process	process	NN
cord-296585-yfh5d4io	310	30	are	be	VBP
cord-296585-yfh5d4io	310	31	currently	currently	RB
cord-296585-yfh5d4io	310	32	unknown	unknown	JJ
cord-296585-yfh5d4io	310	33	.	.	.
cord-296585-yfh5d4io	311	1	Another	another	DT
cord-296585-yfh5d4io	311	2	interesting	interesting	JJ
cord-296585-yfh5d4io	311	3	aspect	aspect	NN
cord-296585-yfh5d4io	311	4	of	of	IN
cord-296585-yfh5d4io	311	5	NTHi	NTHi	NNS
cord-296585-yfh5d4io	311	6	colonization	colonization	NN
cord-296585-yfh5d4io	311	7	of	of	IN
cord-296585-yfh5d4io	311	8	COPD	COPD	NNP
cord-296585-yfh5d4io	311	9	patients	patient	NNS
cord-296585-yfh5d4io	311	10	is	be	VBZ
cord-296585-yfh5d4io	311	11	with	with	IN
cord-296585-yfh5d4io	311	12	regard	regard	NN
cord-296585-yfh5d4io	311	13	to	to	IN
cord-296585-yfh5d4io	311	14	biofilm	biofilm	NN
cord-296585-yfh5d4io	311	15	formation	formation	NN
cord-296585-yfh5d4io	311	16	(	(	-LRB-
cord-296585-yfh5d4io	311	17	229	229	CD
cord-296585-yfh5d4io	311	18	)	)	-RRB-
cord-296585-yfh5d4io	311	19	.	.	.
cord-296585-yfh5d4io	312	1	NTHi	NTHi	NNS
cord-296585-yfh5d4io	312	2	strains	strain	NNS
cord-296585-yfh5d4io	312	3	that	that	WDT
cord-296585-yfh5d4io	312	4	colonize	colonize	VBP
cord-296585-yfh5d4io	312	5	the	the	DT
cord-296585-yfh5d4io	312	6	Eustachian	eustachian	JJ
cord-296585-yfh5d4io	312	7	tube	tube	NN
cord-296585-yfh5d4io	312	8	causing	cause	VBG
cord-296585-yfh5d4io	312	9	otitis	otitis	NN
cord-296585-yfh5d4io	312	10	media	medium	NNS
cord-296585-yfh5d4io	312	11	are	be	VBP
cord-296585-yfh5d4io	312	12	known	know	VBN
cord-296585-yfh5d4io	312	13	to	to	TO
cord-296585-yfh5d4io	312	14	build	build	VB
cord-296585-yfh5d4io	312	15	up	up	RP
cord-296585-yfh5d4io	312	16	biofilms	biofilm	NNS
cord-296585-yfh5d4io	312	17	in	in	IN
cord-296585-yfh5d4io	312	18	situ	situ	NN
cord-296585-yfh5d4io	312	19	(	(	-LRB-
cord-296585-yfh5d4io	312	20	230	230	CD
cord-296585-yfh5d4io	312	21	)	)	-RRB-
cord-296585-yfh5d4io	312	22	.	.	.
cord-296585-yfh5d4io	313	1	However	however	RB
cord-296585-yfh5d4io	313	2	,	,	,
cord-296585-yfh5d4io	313	3	strains	strain	NNS
cord-296585-yfh5d4io	313	4	isolated	isolate	VBN
cord-296585-yfh5d4io	313	5	from	from	IN
cord-296585-yfh5d4io	313	6	COPD	COPD	NNP
cord-296585-yfh5d4io	313	7	patients	patient	NNS
cord-296585-yfh5d4io	313	8	tend	tend	VBP
cord-296585-yfh5d4io	313	9	to	to	TO
cord-296585-yfh5d4io	313	10	have	have	VB
cord-296585-yfh5d4io	313	11	significantly	significantly	RB
cord-296585-yfh5d4io	313	12	diminished	diminish	VBN
cord-296585-yfh5d4io	313	13	ability	ability	NN
cord-296585-yfh5d4io	313	14	to	to	TO
cord-296585-yfh5d4io	313	15	form	form	VB
cord-296585-yfh5d4io	313	16	biofilm	biofilm	NN
cord-296585-yfh5d4io	313	17	compared	compare	VBN
cord-296585-yfh5d4io	313	18	to	to	IN
cord-296585-yfh5d4io	313	19	invasive	invasive	JJ
cord-296585-yfh5d4io	313	20	strains	strain	NNS
cord-296585-yfh5d4io	313	21	or	or	CC
cord-296585-yfh5d4io	313	22	those	those	DT
cord-296585-yfh5d4io	313	23	isolated	isolate	VBN
cord-296585-yfh5d4io	313	24	from	from	IN
cord-296585-yfh5d4io	313	25	otitis	otitis	NN
cord-296585-yfh5d4io	313	26	media	medium	NNS
cord-296585-yfh5d4io	313	27	patients	patient	NNS
cord-296585-yfh5d4io	313	28	(	(	-LRB-
cord-296585-yfh5d4io	313	29	229	229	CD
cord-296585-yfh5d4io	313	30	)	)	-RRB-
cord-296585-yfh5d4io	313	31	,	,	,
cord-296585-yfh5d4io	313	32	suggesting	suggest	VBG
cord-296585-yfh5d4io	313	33	that	that	IN
cord-296585-yfh5d4io	313	34	this	this	DT
cord-296585-yfh5d4io	313	35	mechanism	mechanism	NN
cord-296585-yfh5d4io	313	36	is	be	VBZ
cord-296585-yfh5d4io	313	37	not	not	RB
cord-296585-yfh5d4io	313	38	important	important	JJ
cord-296585-yfh5d4io	313	39	for	for	IN
cord-296585-yfh5d4io	313	40	survival	survival	NN
cord-296585-yfh5d4io	313	41	in	in	IN
cord-296585-yfh5d4io	313	42	the	the	DT
cord-296585-yfh5d4io	313	43	COPD	COPD	NNP
cord-296585-yfh5d4io	313	44	niche	niche	NN
cord-296585-yfh5d4io	313	45	.	.	.
cord-296585-yfh5d4io	314	1	As	as	IN
cord-296585-yfh5d4io	314	2	biofilms	biofilm	NNS
cord-296585-yfh5d4io	314	3	tend	tend	VBP
cord-296585-yfh5d4io	314	4	to	to	TO
cord-296585-yfh5d4io	314	5	protect	protect	VB
cord-296585-yfh5d4io	314	6	the	the	DT
cord-296585-yfh5d4io	314	7	bacterial	bacterial	JJ
cord-296585-yfh5d4io	314	8	community	community	NN
cord-296585-yfh5d4io	314	9	from	from	IN
cord-296585-yfh5d4io	314	10	external	external	JJ
cord-296585-yfh5d4io	314	11	assaults	assault	NNS
cord-296585-yfh5d4io	314	12	,	,	,
cord-296585-yfh5d4io	314	13	these	these	DT
cord-296585-yfh5d4io	314	14	findings	finding	NNS
cord-296585-yfh5d4io	314	15	could	could	MD
cord-296585-yfh5d4io	314	16	indicate	indicate	VB
cord-296585-yfh5d4io	314	17	that	that	IN
cord-296585-yfh5d4io	314	18	the	the	DT
cord-296585-yfh5d4io	314	19	hypermucoid	hypermucoid	JJ
cord-296585-yfh5d4io	314	20	milieu	milieu	NN
cord-296585-yfh5d4io	314	21	in	in	IN
cord-296585-yfh5d4io	314	22	the	the	DT
cord-296585-yfh5d4io	314	23	COPD	COPD	NNP
cord-296585-yfh5d4io	314	24	airways	airways	NNP
cord-296585-yfh5d4io	314	25	is	be	VBZ
cord-296585-yfh5d4io	314	26	severely	severely	RB
cord-296585-yfh5d4io	314	27	impaired	impaired	JJ
cord-296585-yfh5d4io	314	28	in	in	IN
cord-296585-yfh5d4io	314	29	its	-PRON-	PRP$
cord-296585-yfh5d4io	314	30	ability	ability	NN
cord-296585-yfh5d4io	314	31	to	to	TO
cord-296585-yfh5d4io	314	32	deliver	deliver	VB
cord-296585-yfh5d4io	314	33	an	an	DT
cord-296585-yfh5d4io	314	34	apt	apt	JJ
cord-296585-yfh5d4io	314	35	immune	immune	JJ
cord-296585-yfh5d4io	314	36	response	response	NN
cord-296585-yfh5d4io	314	37	for	for	IN
cord-296585-yfh5d4io	314	38	optimal	optimal	JJ
cord-296585-yfh5d4io	314	39	clearance	clearance	NN
cord-296585-yfh5d4io	314	40	of	of	IN
cord-296585-yfh5d4io	314	41	residing	reside	VBG
cord-296585-yfh5d4io	314	42	microorganisms	microorganism	NNS
cord-296585-yfh5d4io	314	43	.	.	.
cord-296585-yfh5d4io	315	1	In	in	IN
cord-296585-yfh5d4io	315	2	light	light	NN
cord-296585-yfh5d4io	315	3	of	of	IN
cord-296585-yfh5d4io	315	4	this	this	DT
cord-296585-yfh5d4io	315	5	impairment	impairment	NN
cord-296585-yfh5d4io	315	6	,	,	,
cord-296585-yfh5d4io	315	7	biofilm	biofilm	NN
cord-296585-yfh5d4io	315	8	formation	formation	NN
cord-296585-yfh5d4io	315	9	might	may	MD
cord-296585-yfh5d4io	315	10	not	not	RB
cord-296585-yfh5d4io	315	11	be	be	VB
cord-296585-yfh5d4io	315	12	necessary	necessary	JJ
cord-296585-yfh5d4io	315	13	for	for	IN
cord-296585-yfh5d4io	315	14	NTHi	NTHi	NNS
cord-296585-yfh5d4io	315	15	to	to	TO
cord-296585-yfh5d4io	315	16	persist	persist	VB
cord-296585-yfh5d4io	315	17	in	in	IN
cord-296585-yfh5d4io	315	18	this	this	DT
cord-296585-yfh5d4io	315	19	particular	particular	JJ
cord-296585-yfh5d4io	315	20	environment	environment	NN
cord-296585-yfh5d4io	315	21	.	.	.
cord-296585-yfh5d4io	316	1	Infections	infection	NNS
cord-296585-yfh5d4io	316	2	with	with	IN
cord-296585-yfh5d4io	316	3	NTHi	NTHi	NNS
cord-296585-yfh5d4io	316	4	have	have	VBP
cord-296585-yfh5d4io	316	5	also	also	RB
cord-296585-yfh5d4io	316	6	been	be	VBN
cord-296585-yfh5d4io	316	7	shown	show	VBN
cord-296585-yfh5d4io	316	8	to	to	TO
cord-296585-yfh5d4io	316	9	reduce	reduce	VB
cord-296585-yfh5d4io	316	10	cellular	cellular	JJ
cord-296585-yfh5d4io	316	11	levels	level	NNS
cord-296585-yfh5d4io	316	12	of	of	IN
cord-296585-yfh5d4io	316	13	E	e	NN
cord-296585-yfh5d4io	316	14	-	-	NN
cord-296585-yfh5d4io	316	15	cadherin	cadherin	NN
cord-296585-yfh5d4io	316	16	,	,	,
cord-296585-yfh5d4io	316	17	a	a	DT
cord-296585-yfh5d4io	316	18	protein	protein	NN
cord-296585-yfh5d4io	316	19	required	require	VBN
cord-296585-yfh5d4io	316	20	for	for	IN
cord-296585-yfh5d4io	316	21	tight	tight	JJ
cord-296585-yfh5d4io	316	22	junction	junction	NN
cord-296585-yfh5d4io	316	23	formation	formation	NN
cord-296585-yfh5d4io	316	24	and	and	CC
cord-296585-yfh5d4io	316	25	epithelial	epithelial	JJ
cord-296585-yfh5d4io	316	26	cell	cell	NN
cord-296585-yfh5d4io	316	27	integrity	integrity	NN
cord-296585-yfh5d4io	316	28	in	in	IN
cord-296585-yfh5d4io	316	29	human	human	JJ
cord-296585-yfh5d4io	316	30	cells	cell	NNS
cord-296585-yfh5d4io	316	31	(	(	-LRB-
cord-296585-yfh5d4io	316	32	231	231	CD
cord-296585-yfh5d4io	316	33	)	)	-RRB-
cord-296585-yfh5d4io	316	34	.	.	.
cord-296585-yfh5d4io	317	1	Considering	consider	VBG
cord-296585-yfh5d4io	317	2	that	that	IN
cord-296585-yfh5d4io	317	3	perturbations	perturbation	NNS
cord-296585-yfh5d4io	317	4	in	in	IN
cord-296585-yfh5d4io	317	5	the	the	DT
cord-296585-yfh5d4io	317	6	epithelial	epithelial	JJ
cord-296585-yfh5d4io	317	7	cell	cell	NN
cord-296585-yfh5d4io	317	8	barrier	barrier	NN
cord-296585-yfh5d4io	317	9	caused	cause	VBN
cord-296585-yfh5d4io	317	10	by	by	IN
cord-296585-yfh5d4io	317	11	the	the	DT
cord-296585-yfh5d4io	317	12	loss	loss	NN
cord-296585-yfh5d4io	317	13	of	of	IN
cord-296585-yfh5d4io	317	14	E	e	NN
cord-296585-yfh5d4io	317	15	-	-	NN
cord-296585-yfh5d4io	317	16	cadherin	cadherin	NN
cord-296585-yfh5d4io	317	17	is	be	VBZ
cord-296585-yfh5d4io	317	18	a	a	DT
cord-296585-yfh5d4io	317	19	common	common	JJ
cord-296585-yfh5d4io	317	20	symptom	symptom	NN
cord-296585-yfh5d4io	317	21	of	of	IN
cord-296585-yfh5d4io	317	22	COPD	COPD	NNP
cord-296585-yfh5d4io	317	23	,	,	,
cord-296585-yfh5d4io	317	24	NTHi	NTHi	NNS
cord-296585-yfh5d4io	317	25	-	-	HYPH
cord-296585-yfh5d4io	317	26	mediated	mediate	VBN
cord-296585-yfh5d4io	317	27	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	317	28	likely	likely	RB
cord-296585-yfh5d4io	317	29	contribute	contribute	VBP
cord-296585-yfh5d4io	317	30	to	to	IN
cord-296585-yfh5d4io	317	31	this	this	DT
cord-296585-yfh5d4io	317	32	step	step	NN
cord-296585-yfh5d4io	317	33	of	of	IN
cord-296585-yfh5d4io	317	34	COPD	COPD	NNP
cord-296585-yfh5d4io	317	35	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	317	36	.	.	.
cord-296585-yfh5d4io	318	1	The	the	DT
cord-296585-yfh5d4io	318	2	subsequent	subsequent	JJ
cord-296585-yfh5d4io	318	3	denuding	denuding	NN
cord-296585-yfh5d4io	318	4	of	of	IN
cord-296585-yfh5d4io	318	5	the	the	DT
cord-296585-yfh5d4io	318	6	epithelium	epithelium	NN
cord-296585-yfh5d4io	318	7	could	could	MD
cord-296585-yfh5d4io	318	8	facilitate	facilitate	VB
cord-296585-yfh5d4io	318	9	microbial	microbial	JJ
cord-296585-yfh5d4io	318	10	colonization	colonization	NN
cord-296585-yfh5d4io	318	11	of	of	IN
cord-296585-yfh5d4io	318	12	the	the	DT
cord-296585-yfh5d4io	318	13	basal	basal	NN
cord-296585-yfh5d4io	318	14	lamina	lamina	NN
cord-296585-yfh5d4io	318	15	,	,	,
cord-296585-yfh5d4io	318	16	a	a	DT
cord-296585-yfh5d4io	318	17	well	well	RB
cord-296585-yfh5d4io	318	18	-	-	HYPH
cord-296585-yfh5d4io	318	19	established	establish	VBN
cord-296585-yfh5d4io	318	20	virulence	virulence	NN
cord-296585-yfh5d4io	318	21	mechanism	mechanism	NN
cord-296585-yfh5d4io	318	22	employed	employ	VBN
cord-296585-yfh5d4io	318	23	by	by	IN
cord-296585-yfh5d4io	318	24	NTHi	NTHi	NNS
cord-296585-yfh5d4io	318	25	and	and	CC
cord-296585-yfh5d4io	318	26	other	other	JJ
cord-296585-yfh5d4io	318	27	pathogens	pathogen	NNS
cord-296585-yfh5d4io	318	28	(	(	-LRB-
cord-296585-yfh5d4io	318	29	232	232	CD
cord-296585-yfh5d4io	318	30	)	)	-RRB-
cord-296585-yfh5d4io	318	31	.	.	.
cord-296585-yfh5d4io	319	1	It	-PRON-	PRP
cord-296585-yfh5d4io	319	2	is	be	VBZ
cord-296585-yfh5d4io	319	3	currently	currently	RB
cord-296585-yfh5d4io	319	4	unknown	unknown	JJ
cord-296585-yfh5d4io	319	5	which	which	WDT
cord-296585-yfh5d4io	319	6	bacterial	bacterial	JJ
cord-296585-yfh5d4io	319	7	virulence	virulence	NN
cord-296585-yfh5d4io	319	8	factor(s	factor(s	NNP
cord-296585-yfh5d4io	319	9	)	)	-RRB-
cord-296585-yfh5d4io	319	10	that	that	WDT
cord-296585-yfh5d4io	319	11	induce	induce	VBP
cord-296585-yfh5d4io	319	12	the	the	DT
cord-296585-yfh5d4io	319	13	reduction	reduction	NN
cord-296585-yfh5d4io	319	14	of	of	IN
cord-296585-yfh5d4io	319	15	E	e	NN
cord-296585-yfh5d4io	319	16	-	-	NN
cord-296585-yfh5d4io	319	17	cadherin	cadherin	JJ
cord-296585-yfh5d4io	319	18	levels	level	NNS
cord-296585-yfh5d4io	319	19	in	in	IN
cord-296585-yfh5d4io	319	20	the	the	DT
cord-296585-yfh5d4io	319	21	host	host	NN
cord-296585-yfh5d4io	319	22	.	.	.
cord-296585-yfh5d4io	320	1	In	in	IN
cord-296585-yfh5d4io	320	2	summary	summary	NN
cord-296585-yfh5d4io	320	3	,	,	,
cord-296585-yfh5d4io	320	4	investigations	investigation	NNS
cord-296585-yfh5d4io	320	5	from	from	IN
cord-296585-yfh5d4io	320	6	recent	recent	JJ
cord-296585-yfh5d4io	320	7	years	year	NNS
cord-296585-yfh5d4io	320	8	show	show	VBP
cord-296585-yfh5d4io	320	9	that	that	IN
cord-296585-yfh5d4io	320	10	the	the	DT
cord-296585-yfh5d4io	320	11	environment	environment	NN
cord-296585-yfh5d4io	320	12	of	of	IN
cord-296585-yfh5d4io	320	13	the	the	DT
cord-296585-yfh5d4io	320	14	lower	low	JJR
cord-296585-yfh5d4io	320	15	respiratory	respiratory	JJ
cord-296585-yfh5d4io	320	16	tract	tract	NN
cord-296585-yfh5d4io	320	17	of	of	IN
cord-296585-yfh5d4io	320	18	COPD	COPD	NNP
cord-296585-yfh5d4io	320	19	patients	patient	NNS
cord-296585-yfh5d4io	320	20	selects	select	VBZ
cord-296585-yfh5d4io	320	21	for	for	IN
cord-296585-yfh5d4io	320	22	NTHi	NTHi	NNS
cord-296585-yfh5d4io	320	23	strains	strain	NNS
cord-296585-yfh5d4io	320	24	that	that	WDT
cord-296585-yfh5d4io	320	25	can	can	MD
cord-296585-yfh5d4io	320	26	upregulate	upregulate	VB
cord-296585-yfh5d4io	320	27	adhesins	adhesin	NNS
cord-296585-yfh5d4io	320	28	,	,	,
cord-296585-yfh5d4io	320	29	modify	modify	VB
cord-296585-yfh5d4io	320	30	LOS	LOS	NNP
cord-296585-yfh5d4io	320	31	biosynthesis	biosynthesis	NN
cord-296585-yfh5d4io	320	32	pathways	pathway	NNS
cord-296585-yfh5d4io	320	33	,	,	,
cord-296585-yfh5d4io	320	34	increase	increase	VB
cord-296585-yfh5d4io	320	35	antioxidant	antioxidant	JJ
cord-296585-yfh5d4io	320	36	stress	stress	NN
cord-296585-yfh5d4io	320	37	responses	response	NNS
cord-296585-yfh5d4io	320	38	and	and	CC
cord-296585-yfh5d4io	320	39	cellular	cellular	JJ
cord-296585-yfh5d4io	320	40	invasion	invasion	NN
cord-296585-yfh5d4io	320	41	strategies	strategy	NNS
cord-296585-yfh5d4io	320	42	,	,	,
cord-296585-yfh5d4io	320	43	and	and	CC
cord-296585-yfh5d4io	320	44	,	,	,
cord-296585-yfh5d4io	320	45	finally	finally	RB
cord-296585-yfh5d4io	320	46	,	,	,
cord-296585-yfh5d4io	320	47	trigger	trigger	VB
cord-296585-yfh5d4io	320	48	tolerance	tolerance	NN
cord-296585-yfh5d4io	320	49	against	against	IN
cord-296585-yfh5d4io	320	50	acidic	acidic	JJ
cord-296585-yfh5d4io	320	51	pH.	ph.	NN
cord-296585-yfh5d4io	321	1	These	these	DT
cord-296585-yfh5d4io	321	2	important	important	JJ
cord-296585-yfh5d4io	321	3	colonization	colonization	NN
cord-296585-yfh5d4io	321	4	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	321	5	thus	thus	RB
cord-296585-yfh5d4io	321	6	provide	provide	VBP
cord-296585-yfh5d4io	321	7	researchers	researcher	NNS
cord-296585-yfh5d4io	321	8	with	with	IN
cord-296585-yfh5d4io	321	9	viable	viable	JJ
cord-296585-yfh5d4io	321	10	targets	target	NNS
cord-296585-yfh5d4io	321	11	for	for	IN
cord-296585-yfh5d4io	321	12	developing	develop	VBG
cord-296585-yfh5d4io	321	13	novel	novel	JJ
cord-296585-yfh5d4io	321	14	therapies	therapy	NNS
cord-296585-yfh5d4io	321	15	.	.	.
cord-296585-yfh5d4io	322	1	NTHi	NTHi	NNP
cord-296585-yfh5d4io	322	2	is	be	VBZ
cord-296585-yfh5d4io	322	3	a	a	DT
cord-296585-yfh5d4io	322	4	commensal	commensal	NN
cord-296585-yfh5d4io	322	5	in	in	IN
cord-296585-yfh5d4io	322	6	the	the	DT
cord-296585-yfh5d4io	322	7	nasopharyngeal	nasopharyngeal	JJ
cord-296585-yfh5d4io	322	8	site	site	NN
cord-296585-yfh5d4io	322	9	but	but	CC
cord-296585-yfh5d4io	322	10	is	be	VBZ
cord-296585-yfh5d4io	322	11	often	often	RB
cord-296585-yfh5d4io	322	12	associated	associate	VBN
cord-296585-yfh5d4io	322	13	with	with	IN
cord-296585-yfh5d4io	322	14	strong	strong	JJ
cord-296585-yfh5d4io	322	15	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	322	16	responses	response	NNS
cord-296585-yfh5d4io	322	17	in	in	IN
cord-296585-yfh5d4io	322	18	the	the	DT
cord-296585-yfh5d4io	322	19	lower	low	JJR
cord-296585-yfh5d4io	322	20	respiratory	respiratory	JJ
cord-296585-yfh5d4io	322	21	airways	airway	NNS
cord-296585-yfh5d4io	322	22	,	,	,
cord-296585-yfh5d4io	322	23	especially	especially	RB
cord-296585-yfh5d4io	322	24	in	in	IN
cord-296585-yfh5d4io	322	25	patients	patient	NNS
cord-296585-yfh5d4io	322	26	with	with	IN
cord-296585-yfh5d4io	322	27	COPD	COPD	NNP
cord-296585-yfh5d4io	322	28	,	,	,
cord-296585-yfh5d4io	322	29	bronchiectasis	bronchiectasis	NN
cord-296585-yfh5d4io	322	30	,	,	,
cord-296585-yfh5d4io	322	31	cystic	cystic	JJ
cord-296585-yfh5d4io	322	32	fibrosis	fibrosis	NN
cord-296585-yfh5d4io	322	33	,	,	,
cord-296585-yfh5d4io	322	34	pneumonia	pneumonia	NN
cord-296585-yfh5d4io	322	35	,	,	,
cord-296585-yfh5d4io	322	36	or	or	CC
cord-296585-yfh5d4io	322	37	idiopathic	idiopathic	JJ
cord-296585-yfh5d4io	322	38	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	322	39	fibrosis	fibrosis	NN
cord-296585-yfh5d4io	322	40	(	(	-LRB-
cord-296585-yfh5d4io	322	41	11	11	CD
cord-296585-yfh5d4io	322	42	,	,	,
cord-296585-yfh5d4io	322	43	233	233	CD
cord-296585-yfh5d4io	322	44	)	)	-RRB-
cord-296585-yfh5d4io	322	45	.	.	.
cord-296585-yfh5d4io	323	1	Colonization	colonization	NN
cord-296585-yfh5d4io	323	2	and	and	CC
cord-296585-yfh5d4io	323	3	subsequent	subsequent	JJ
cord-296585-yfh5d4io	323	4	infection	infection	NN
cord-296585-yfh5d4io	323	5	of	of	IN
cord-296585-yfh5d4io	323	6	NTHi	NTHi	NNS
cord-296585-yfh5d4io	323	7	in	in	IN
cord-296585-yfh5d4io	323	8	the	the	DT
cord-296585-yfh5d4io	323	9	lower	low	JJR
cord-296585-yfh5d4io	323	10	airways	airway	NNS
cord-296585-yfh5d4io	323	11	of	of	IN
cord-296585-yfh5d4io	323	12	COPD	COPD	NNP
cord-296585-yfh5d4io	323	13	patients	patient	NNS
cord-296585-yfh5d4io	323	14	elicits	elicit	VBZ
cord-296585-yfh5d4io	323	15	episodes	episode	NNS
cord-296585-yfh5d4io	323	16	of	of	IN
cord-296585-yfh5d4io	323	17	immune	immune	JJ
cord-296585-yfh5d4io	323	18	responses	response	NNS
cord-296585-yfh5d4io	323	19	orchestrated	orchestrate	VBN
cord-296585-yfh5d4io	323	20	by	by	IN
cord-296585-yfh5d4io	323	21	both	both	CC
cord-296585-yfh5d4io	323	22	the	the	DT
cord-296585-yfh5d4io	323	23	innate	innate	JJ
cord-296585-yfh5d4io	323	24	and	and	CC
cord-296585-yfh5d4io	323	25	adaptive	adaptive	JJ
cord-296585-yfh5d4io	323	26	immunity	immunity	NN
cord-296585-yfh5d4io	323	27	.	.	.
cord-296585-yfh5d4io	324	1	NTHi	NTHi	NNS
cord-296585-yfh5d4io	324	2	infection	infection	NN
cord-296585-yfh5d4io	324	3	is	be	VBZ
cord-296585-yfh5d4io	324	4	thus	thus	RB
cord-296585-yfh5d4io	324	5	commonly	commonly	RB
cord-296585-yfh5d4io	324	6	associated	associate	VBN
cord-296585-yfh5d4io	324	7	with	with	IN
cord-296585-yfh5d4io	324	8	inflammation	inflammation	NN
cord-296585-yfh5d4io	324	9	that	that	WDT
cord-296585-yfh5d4io	324	10	is	be	VBZ
cord-296585-yfh5d4io	324	11	mainly	mainly	RB
cord-296585-yfh5d4io	324	12	mediated	mediate	VBN
cord-296585-yfh5d4io	324	13	by	by	IN
cord-296585-yfh5d4io	324	14	transcription	transcription	NN
cord-296585-yfh5d4io	324	15	factor	factor	NN
cord-296585-yfh5d4io	324	16	NF	nf	NN
cord-296585-yfh5d4io	324	17	-	-	HYPH
cord-296585-yfh5d4io	324	18	κB	κB	NNP
cord-296585-yfh5d4io	324	19	-	-	HYPH
cord-296585-yfh5d4io	324	20	dependent	dependent	JJ
cord-296585-yfh5d4io	324	21	production	production	NN
cord-296585-yfh5d4io	324	22	of	of	IN
cord-296585-yfh5d4io	324	23	proinflammatory	proinflammatory	JJ
cord-296585-yfh5d4io	324	24	mediators	mediator	NNS
cord-296585-yfh5d4io	324	25	.	.	.
cord-296585-yfh5d4io	325	1	The	the	DT
cord-296585-yfh5d4io	325	2	activation	activation	NN
cord-296585-yfh5d4io	325	3	of	of	IN
cord-296585-yfh5d4io	325	4	NF	nf	NN
cord-296585-yfh5d4io	325	5	-	-	HYPH
cord-296585-yfh5d4io	325	6	κB	κB	NNP
cord-296585-yfh5d4io	325	7	requires	require	VBZ
cord-296585-yfh5d4io	325	8	induction	induction	NN
cord-296585-yfh5d4io	325	9	of	of	IN
cord-296585-yfh5d4io	325	10	cross	cross	NN
cord-296585-yfh5d4io	325	11	-	-	JJ
cord-296585-yfh5d4io	325	12	signaling	signal	VBG
cord-296585-yfh5d4io	325	13	networks	network	NNS
cord-296585-yfh5d4io	325	14	and	and	CC
cord-296585-yfh5d4io	325	15	cascades	cascade	NNS
cord-296585-yfh5d4io	325	16	via	via	IN
cord-296585-yfh5d4io	325	17	activation	activation	NN
cord-296585-yfh5d4io	325	18	of	of	IN
cord-296585-yfh5d4io	325	19	PRRs	PRRs	NNP
cord-296585-yfh5d4io	325	20	(	(	-LRB-
cord-296585-yfh5d4io	325	21	pattern	pattern	NN
cord-296585-yfh5d4io	325	22	recognition	recognition	NN
cord-296585-yfh5d4io	325	23	receptors	receptor	NNS
cord-296585-yfh5d4io	325	24	)	)	-RRB-
cord-296585-yfh5d4io	325	25	of	of	IN
cord-296585-yfh5d4io	325	26	host	host	NN
cord-296585-yfh5d4io	325	27	innate	innate	JJ
cord-296585-yfh5d4io	325	28	immune	immune	JJ
cord-296585-yfh5d4io	325	29	cells	cell	NNS
cord-296585-yfh5d4io	325	30	(	(	-LRB-
cord-296585-yfh5d4io	325	31	234	234	CD
cord-296585-yfh5d4io	325	32	)	)	-RRB-
cord-296585-yfh5d4io	325	33	.	.	.
cord-296585-yfh5d4io	326	1	Unresolved	unresolved	JJ
cord-296585-yfh5d4io	326	2	or	or	CC
cord-296585-yfh5d4io	326	3	prolonged	prolong	VBN
cord-296585-yfh5d4io	326	4	(	(	-LRB-
cord-296585-yfh5d4io	326	5	chronic	chronic	JJ
cord-296585-yfh5d4io	326	6	)	)	-RRB-
cord-296585-yfh5d4io	326	7	inflammation	inflammation	NN
cord-296585-yfh5d4io	326	8	or	or	CC
cord-296585-yfh5d4io	326	9	failure	failure	NN
cord-296585-yfh5d4io	326	10	to	to	TO
cord-296585-yfh5d4io	326	11	restore	restore	VB
cord-296585-yfh5d4io	326	12	the	the	DT
cord-296585-yfh5d4io	326	13	homeostatic	homeostatic	JJ
cord-296585-yfh5d4io	326	14	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	326	15	status	status	NN
cord-296585-yfh5d4io	326	16	potentially	potentially	RB
cord-296585-yfh5d4io	326	17	contributes	contribute	VBZ
cord-296585-yfh5d4io	326	18	to	to	IN
cord-296585-yfh5d4io	326	19	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	326	20	.	.	.
cord-296585-yfh5d4io	327	1	This	this	DT
cord-296585-yfh5d4io	327	2	is	be	VBZ
cord-296585-yfh5d4io	327	3	clearly	clearly	RB
cord-296585-yfh5d4io	327	4	shown	show	VBN
cord-296585-yfh5d4io	327	5	in	in	IN
cord-296585-yfh5d4io	327	6	murine	murine	JJ
cord-296585-yfh5d4io	327	7	COPD	COPD	NNP
cord-296585-yfh5d4io	327	8	simulation	simulation	NN
cord-296585-yfh5d4io	327	9	models	model	NNS
cord-296585-yfh5d4io	327	10	with	with	IN
cord-296585-yfh5d4io	327	11	NTHi	NTHi	NNS
cord-296585-yfh5d4io	327	12	-	-	HYPH
cord-296585-yfh5d4io	327	13	triggered	trigger	VBN
cord-296585-yfh5d4io	327	14	inflammation	inflammation	NN
cord-296585-yfh5d4io	327	15	(	(	-LRB-
cord-296585-yfh5d4io	327	16	235	235	CD
cord-296585-yfh5d4io	327	17	-	-	SYM
cord-296585-yfh5d4io	327	18	237	237	CD
cord-296585-yfh5d4io	327	19	)	)	-RRB-
cord-296585-yfh5d4io	327	20	.	.	.
cord-296585-yfh5d4io	328	1	Mice	mouse	NNS
cord-296585-yfh5d4io	328	2	exposed	expose	VBN
cord-296585-yfh5d4io	328	3	to	to	IN
cord-296585-yfh5d4io	328	4	NTHi	NTHi	NNP
cord-296585-yfh5d4io	328	5	lysates	lysates	NNP
cord-296585-yfh5d4io	328	6	display	display	NN
cord-296585-yfh5d4io	328	7	inflamed	inflame	VBN
cord-296585-yfh5d4io	328	8	airways	airway	NNS
cord-296585-yfh5d4io	328	9	loaded	load	VBN
cord-296585-yfh5d4io	328	10	with	with	IN
cord-296585-yfh5d4io	328	11	increased	increase	VBN
cord-296585-yfh5d4io	328	12	levels	level	NNS
cord-296585-yfh5d4io	328	13	of	of	IN
cord-296585-yfh5d4io	328	14	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	328	15	mediators	mediator	NNS
cord-296585-yfh5d4io	328	16	and	and	CC
cord-296585-yfh5d4io	328	17	phagocyte	phagocyte	NNP
cord-296585-yfh5d4io	328	18	infiltrates	infiltrate	VBZ
cord-296585-yfh5d4io	328	19	.	.	.
cord-296585-yfh5d4io	329	1	Moreover	moreover	RB
cord-296585-yfh5d4io	329	2	,	,	,
cord-296585-yfh5d4io	329	3	multiple	multiple	JJ
cord-296585-yfh5d4io	329	4	exposures	exposure	NNS
cord-296585-yfh5d4io	329	5	to	to	IN
cord-296585-yfh5d4io	329	6	bacterial	bacterial	JJ
cord-296585-yfh5d4io	329	7	lysates	lysate	NNS
cord-296585-yfh5d4io	329	8	which	which	WDT
cord-296585-yfh5d4io	329	9	may	may	MD
cord-296585-yfh5d4io	329	10	represent	represent	VB
cord-296585-yfh5d4io	329	11	a	a	DT
cord-296585-yfh5d4io	329	12	chronic	chronic	JJ
cord-296585-yfh5d4io	329	13	NTHi	NTHi	NNS
cord-296585-yfh5d4io	329	14	infection	infection	NN
cord-296585-yfh5d4io	329	15	caused	cause	VBD
cord-296585-yfh5d4io	329	16	extremely	extremely	RB
cord-296585-yfh5d4io	329	17	high	high	JJ
cord-296585-yfh5d4io	329	18	infiltration	infiltration	NN
cord-296585-yfh5d4io	329	19	of	of	IN
cord-296585-yfh5d4io	329	20	phagocytes	phagocyte	NNS
cord-296585-yfh5d4io	329	21	and	and	CC
cord-296585-yfh5d4io	329	22	lymphocytes	lymphocyte	NNS
cord-296585-yfh5d4io	329	23	in	in	IN
cord-296585-yfh5d4io	329	24	the	the	DT
cord-296585-yfh5d4io	329	25	airways	airway	NNS
cord-296585-yfh5d4io	329	26	of	of	IN
cord-296585-yfh5d4io	329	27	this	this	DT
cord-296585-yfh5d4io	329	28	particular	particular	JJ
cord-296585-yfh5d4io	329	29	mouse	mouse	NN
cord-296585-yfh5d4io	329	30	model	model	NN
cord-296585-yfh5d4io	329	31	.	.	.
cord-296585-yfh5d4io	330	1	In	in	IN
cord-296585-yfh5d4io	330	2	addition	addition	NN
cord-296585-yfh5d4io	330	3	,	,	,
cord-296585-yfh5d4io	330	4	the	the	DT
cord-296585-yfh5d4io	330	5	airway	airway	NN
cord-296585-yfh5d4io	330	6	walls	wall	NNS
cord-296585-yfh5d4io	330	7	of	of	IN
cord-296585-yfh5d4io	330	8	the	the	DT
cord-296585-yfh5d4io	330	9	infected	infected	JJ
cord-296585-yfh5d4io	330	10	animals	animal	NNS
cord-296585-yfh5d4io	330	11	were	be	VBD
cord-296585-yfh5d4io	330	12	also	also	RB
cord-296585-yfh5d4io	330	13	thickened	thicken	VBN
cord-296585-yfh5d4io	330	14	due	due	IN
cord-296585-yfh5d4io	330	15	to	to	IN
cord-296585-yfh5d4io	330	16	increased	increase	VBN
cord-296585-yfh5d4io	330	17	collagen	collagen	NN
cord-296585-yfh5d4io	330	18	deposition	deposition	NN
cord-296585-yfh5d4io	330	19	(	(	-LRB-
cord-296585-yfh5d4io	330	20	fibrosis	fibrosis	NN
cord-296585-yfh5d4io	330	21	)	)	-RRB-
cord-296585-yfh5d4io	330	22	that	that	WDT
cord-296585-yfh5d4io	330	23	reflects	reflect	VBZ
cord-296585-yfh5d4io	330	24	the	the	DT
cord-296585-yfh5d4io	330	25	typical	typical	JJ
cord-296585-yfh5d4io	330	26	COPD	COPD	NNP
cord-296585-yfh5d4io	330	27	features	feature	NNS
cord-296585-yfh5d4io	330	28	.	.	.
cord-296585-yfh5d4io	331	1	The	the	DT
cord-296585-yfh5d4io	331	2	host	host	NN
cord-296585-yfh5d4io	331	3	immune	immune	JJ
cord-296585-yfh5d4io	331	4	response	response	NN
cord-296585-yfh5d4io	331	5	and	and	CC
cord-296585-yfh5d4io	331	6	specific	specific	JJ
cord-296585-yfh5d4io	331	7	interactions	interaction	NNS
cord-296585-yfh5d4io	331	8	during	during	IN
cord-296585-yfh5d4io	331	9	NTHi	NTHi	NNS
cord-296585-yfh5d4io	331	10	infection	infection	NN
cord-296585-yfh5d4io	331	11	in	in	IN
cord-296585-yfh5d4io	331	12	COPD	COPD	NNP
cord-296585-yfh5d4io	331	13	is	be	VBZ
cord-296585-yfh5d4io	331	14	summarized	summarize	VBN
cord-296585-yfh5d4io	331	15	in	in	IN
cord-296585-yfh5d4io	331	16	Figure	Figure	NNP
cord-296585-yfh5d4io	331	17	2	2	CD
cord-296585-yfh5d4io	331	18	.	.	.
cord-296585-yfh5d4io	332	1	The	the	DT
cord-296585-yfh5d4io	332	2	epithelium	epithelium	NN
cord-296585-yfh5d4io	332	3	and	and	CC
cord-296585-yfh5d4io	332	4	alveolar	alveolar	JJ
cord-296585-yfh5d4io	332	5	macrophages	macrophage	NNS
cord-296585-yfh5d4io	332	6	are	be	VBP
cord-296585-yfh5d4io	332	7	predominant	predominant	JJ
cord-296585-yfh5d4io	332	8	cell	cell	NN
cord-296585-yfh5d4io	332	9	types	type	NNS
cord-296585-yfh5d4io	332	10	in	in	IN
cord-296585-yfh5d4io	332	11	the	the	DT
cord-296585-yfh5d4io	332	12	airway	airway	NNP
cord-296585-yfh5d4io	332	13	compartment	compartment	NN
cord-296585-yfh5d4io	332	14	.	.	.
cord-296585-yfh5d4io	333	1	They	-PRON-	PRP
cord-296585-yfh5d4io	333	2	comprise	comprise	VBP
cord-296585-yfh5d4io	333	3	the	the	DT
cord-296585-yfh5d4io	333	4	first	first	JJ
cord-296585-yfh5d4io	333	5	line	line	NN
cord-296585-yfh5d4io	333	6	of	of	IN
cord-296585-yfh5d4io	333	7	defense	defense	NN
cord-296585-yfh5d4io	333	8	in	in	IN
cord-296585-yfh5d4io	333	9	the	the	DT
cord-296585-yfh5d4io	333	10	cellular	cellular	JJ
cord-296585-yfh5d4io	333	11	immune	immune	JJ
cord-296585-yfh5d4io	333	12	response	response	NN
cord-296585-yfh5d4io	333	13	against	against	IN
cord-296585-yfh5d4io	333	14	potential	potential	JJ
cord-296585-yfh5d4io	333	15	inhaled	inhale	VBN
cord-296585-yfh5d4io	333	16	pathogens	pathogen	NNS
cord-296585-yfh5d4io	333	17	and	and	CC
cord-296585-yfh5d4io	333	18	antigens	antigen	NNS
cord-296585-yfh5d4io	333	19	.	.	.
cord-296585-yfh5d4io	334	1	The	the	DT
cord-296585-yfh5d4io	334	2	sensing	sensing	NN
cord-296585-yfh5d4io	334	3	of	of	IN
cord-296585-yfh5d4io	334	4	bacteria	bacteria	NNS
cord-296585-yfh5d4io	334	5	,	,	,
cord-296585-yfh5d4io	334	6	and	and	CC
cord-296585-yfh5d4io	334	7	particularly	particularly	RB
cord-296585-yfh5d4io	334	8	NTHi	NTHi	VBZ
cord-296585-yfh5d4io	334	9	in	in	IN
cord-296585-yfh5d4io	334	10	the	the	DT
cord-296585-yfh5d4io	334	11	lower	low	JJR
cord-296585-yfh5d4io	334	12	airways	airway	NNS
cord-296585-yfh5d4io	334	13	is	be	VBZ
cord-296585-yfh5d4io	334	14	initiated	initiate	VBN
cord-296585-yfh5d4io	334	15	via	via	IN
cord-296585-yfh5d4io	334	16	PRRs	prr	NNS
cord-296585-yfh5d4io	334	17	expressed	express	VBN
cord-296585-yfh5d4io	334	18	on	on	IN
cord-296585-yfh5d4io	334	19	innate	innate	JJ
cord-296585-yfh5d4io	334	20	immune	immune	JJ
cord-296585-yfh5d4io	334	21	cells	cell	NNS
cord-296585-yfh5d4io	334	22	and	and	CC
cord-296585-yfh5d4io	334	23	endothelium	endothelium	NN
cord-296585-yfh5d4io	334	24	in	in	IN
cord-296585-yfh5d4io	334	25	addition	addition	NN
cord-296585-yfh5d4io	334	26	to	to	IN
cord-296585-yfh5d4io	334	27	epithelial	epithelial	JJ
cord-296585-yfh5d4io	334	28	cells	cell	NNS
cord-296585-yfh5d4io	334	29	(	(	-LRB-
cord-296585-yfh5d4io	334	30	238	238	CD
cord-296585-yfh5d4io	334	31	)	)	-RRB-
cord-296585-yfh5d4io	334	32	(	(	-LRB-
cord-296585-yfh5d4io	334	33	239	239	CD
cord-296585-yfh5d4io	334	34	)	)	-RRB-
cord-296585-yfh5d4io	334	35	(	(	-LRB-
cord-296585-yfh5d4io	334	36	240	240	CD
cord-296585-yfh5d4io	334	37	)	)	-RRB-
cord-296585-yfh5d4io	334	38	.	.	.
cord-296585-yfh5d4io	335	1	TLRs	TLRs	NNP
cord-296585-yfh5d4io	335	2	are	be	VBP
cord-296585-yfh5d4io	335	3	PRRs	prr	NNS
cord-296585-yfh5d4io	335	4	that	that	WDT
cord-296585-yfh5d4io	335	5	sense	sense	VBP
cord-296585-yfh5d4io	335	6	stimulation	stimulation	NN
cord-296585-yfh5d4io	335	7	by	by	IN
cord-296585-yfh5d4io	335	8	NTHiderived	nthiderived	JJ
cord-296585-yfh5d4io	335	9	pathogen	pathogen	NN
cord-296585-yfh5d4io	335	10	-	-	HYPH
cord-296585-yfh5d4io	335	11	associated	associate	VBN
cord-296585-yfh5d4io	335	12	molecular	molecular	JJ
cord-296585-yfh5d4io	335	13	patterns	pattern	NNS
cord-296585-yfh5d4io	335	14	(	(	-LRB-
cord-296585-yfh5d4io	335	15	PAMPs	PAMPs	NNP
cord-296585-yfh5d4io	335	16	)	)	-RRB-
cord-296585-yfh5d4io	335	17	,	,	,
cord-296585-yfh5d4io	335	18	and	and	CC
cord-296585-yfh5d4io	335	19	play	play	VB
cord-296585-yfh5d4io	335	20	a	a	DT
cord-296585-yfh5d4io	335	21	primary	primary	JJ
cord-296585-yfh5d4io	335	22	role	role	NN
cord-296585-yfh5d4io	335	23	in	in	IN
cord-296585-yfh5d4io	335	24	initiating	initiate	VBG
cord-296585-yfh5d4io	335	25	effector	effector	JJ
cord-296585-yfh5d4io	335	26	cellular	cellular	JJ
cord-296585-yfh5d4io	335	27	responses	response	NNS
cord-296585-yfh5d4io	335	28	and	and	CC
cord-296585-yfh5d4io	335	29	intracellular	intracellular	JJ
cord-296585-yfh5d4io	335	30	signaling	signaling	NN
cord-296585-yfh5d4io	335	31	for	for	IN
cord-296585-yfh5d4io	335	32	NF	nf	NN
cord-296585-yfh5d4io	335	33	-	-	HYPH
cord-296585-yfh5d4io	335	34	κB	κb	CD
cord-296585-yfh5d4io	335	35	activation	activation	NN
cord-296585-yfh5d4io	335	36	(	(	-LRB-
cord-296585-yfh5d4io	335	37	238	238	CD
cord-296585-yfh5d4io	335	38	)	)	-RRB-
cord-296585-yfh5d4io	335	39	.	.	.
cord-296585-yfh5d4io	336	1	Among	among	IN
cord-296585-yfh5d4io	336	2	the	the	DT
cord-296585-yfh5d4io	336	3	different	different	JJ
cord-296585-yfh5d4io	336	4	TLRs	tlr	NNS
cord-296585-yfh5d4io	336	5	,	,	,
cord-296585-yfh5d4io	336	6	most	most	JJS
cord-296585-yfh5d4io	336	7	of	of	IN
cord-296585-yfh5d4io	336	8	the	the	DT
cord-296585-yfh5d4io	336	9	studies	study	NNS
cord-296585-yfh5d4io	336	10	on	on	IN
cord-296585-yfh5d4io	336	11	NTHi	NTHi	NNS
cord-296585-yfh5d4io	336	12	infection	infection	NN
cord-296585-yfh5d4io	336	13	have	have	VBP
cord-296585-yfh5d4io	336	14	by	by	IN
cord-296585-yfh5d4io	336	15	far	far	RB
cord-296585-yfh5d4io	336	16	been	be	VBN
cord-296585-yfh5d4io	336	17	focused	focus	VBN
cord-296585-yfh5d4io	336	18	on	on	IN
cord-296585-yfh5d4io	336	19	TLR2	TLR2	NNP
cord-296585-yfh5d4io	336	20	and	and	CC
cord-296585-yfh5d4io	336	21	4	4	CD
cord-296585-yfh5d4io	336	22	.	.	.
cord-296585-yfh5d4io	337	1	Lipoproteins	lipoprotein	NNS
cord-296585-yfh5d4io	337	2	including	include	VBG
cord-296585-yfh5d4io	337	3	NTHi	NTHi	NNS
cord-296585-yfh5d4io	337	4	P6	p6	NN
cord-296585-yfh5d4io	337	5	,	,	,
cord-296585-yfh5d4io	337	6	and	and	CC
cord-296585-yfh5d4io	337	7	LOS	LOS	NNP
cord-296585-yfh5d4io	337	8	are	be	VBP
cord-296585-yfh5d4io	337	9	potent	potent	JJ
cord-296585-yfh5d4io	337	10	immunomodulators	immunomodulator	NNS
cord-296585-yfh5d4io	337	11	for	for	IN
cord-296585-yfh5d4io	337	12	activation	activation	NN
cord-296585-yfh5d4io	337	13	of	of	IN
cord-296585-yfh5d4io	337	14	TLR2	TLR2	NNP
cord-296585-yfh5d4io	337	15	and	and	CC
cord-296585-yfh5d4io	337	16	TLR4	TLR4	NNP
cord-296585-yfh5d4io	337	17	,	,	,
cord-296585-yfh5d4io	337	18	respectively	respectively	RB
cord-296585-yfh5d4io	337	19	,	,	,
cord-296585-yfh5d4io	337	20	and	and	CC
cord-296585-yfh5d4io	337	21	has	have	VBZ
cord-296585-yfh5d4io	337	22	been	be	VBN
cord-296585-yfh5d4io	337	23	described	describe	VBN
cord-296585-yfh5d4io	337	24	in	in	IN
cord-296585-yfh5d4io	337	25	several	several	JJ
cord-296585-yfh5d4io	337	26	studies	study	NNS
cord-296585-yfh5d4io	337	27	on	on	IN
cord-296585-yfh5d4io	337	28	airway	airway	JJ
cord-296585-yfh5d4io	337	29	epithelial	epithelial	JJ
cord-296585-yfh5d4io	337	30	cells	cell	NNS
cord-296585-yfh5d4io	337	31	and	and	CC
cord-296585-yfh5d4io	337	32	alveolar	alveolar	NN
cord-296585-yfh5d4io	337	33	macrophages	macrophage	NNS
cord-296585-yfh5d4io	337	34	(	(	-LRB-
cord-296585-yfh5d4io	337	35	241	241	CD
cord-296585-yfh5d4io	337	36	)	)	-RRB-
cord-296585-yfh5d4io	337	37	(	(	-LRB-
cord-296585-yfh5d4io	337	38	242	242	CD
cord-296585-yfh5d4io	337	39	)	)	-RRB-
cord-296585-yfh5d4io	337	40	(	(	-LRB-
cord-296585-yfh5d4io	337	41	243	243	CD
cord-296585-yfh5d4io	337	42	)	)	-RRB-
cord-296585-yfh5d4io	337	43	(	(	-LRB-
cord-296585-yfh5d4io	337	44	244	244	CD
cord-296585-yfh5d4io	337	45	)	)	-RRB-
cord-296585-yfh5d4io	337	46	.	.	.
cord-296585-yfh5d4io	338	1	Interaction	Interaction	NNP
cord-296585-yfh5d4io	338	2	of	of	IN
cord-296585-yfh5d4io	338	3	NTHi	NTHi	NNP
cord-296585-yfh5d4io	338	4	lipoprotein	lipoprotein	NN
cord-296585-yfh5d4io	338	5	P6	p6	NN
cord-296585-yfh5d4io	338	6	with	with	IN
cord-296585-yfh5d4io	338	7	TLR2	TLR2	NNP
cord-296585-yfh5d4io	338	8	on	on	IN
cord-296585-yfh5d4io	338	9	human	human	JJ
cord-296585-yfh5d4io	338	10	epithelial	epithelial	JJ
cord-296585-yfh5d4io	338	11	cells	cell	NNS
cord-296585-yfh5d4io	339	1	[	[	-LRB-
cord-296585-yfh5d4io	339	2	type	type	NN
cord-296585-yfh5d4io	339	3	II	ii	CD
cord-296585-yfh5d4io	339	4	alveolar	alveolar	NN
cord-296585-yfh5d4io	339	5	A549	a549	JJ
cord-296585-yfh5d4io	339	6	and	and	CC
cord-296585-yfh5d4io	339	7	human	human	JJ
cord-296585-yfh5d4io	339	8	middle	middle	JJ
cord-296585-yfh5d4io	339	9	ear	ear	NN
cord-296585-yfh5d4io	339	10	epithelial	epithelial	JJ
cord-296585-yfh5d4io	339	11	cells	cell	NNS
cord-296585-yfh5d4io	339	12	(	(	-LRB-
cord-296585-yfh5d4io	339	13	HMEE	HMEE	NNP
cord-296585-yfh5d4io	339	14	)	)	-RRB-
cord-296585-yfh5d4io	339	15	]	]	-RRB-
cord-296585-yfh5d4io	339	16	causes	cause	VBZ
cord-296585-yfh5d4io	339	17	NF	nf	NN
cord-296585-yfh5d4io	339	18	-	-	HYPH
cord-296585-yfh5d4io	339	19	κB	κB	NNP
cord-296585-yfh5d4io	339	20	-	-	HYPH
cord-296585-yfh5d4io	339	21	dependent	dependent	JJ
cord-296585-yfh5d4io	339	22	activation	activation	NN
cord-296585-yfh5d4io	339	23	via	via	IN
cord-296585-yfh5d4io	339	24	two	two	CD
cord-296585-yfh5d4io	339	25	distinct	distinct	JJ
cord-296585-yfh5d4io	339	26	TLR	tlr	NN
cord-296585-yfh5d4io	339	27	-	-	HYPH
cord-296585-yfh5d4io	339	28	signaling	signal	VBG
cord-296585-yfh5d4io	339	29	pathways	pathway	NNS
cord-296585-yfh5d4io	339	30	,	,	,
cord-296585-yfh5d4io	339	31	that	that	RB
cord-296585-yfh5d4io	339	32	is	is	RB
cord-296585-yfh5d4io	339	33	,	,	,
cord-296585-yfh5d4io	339	34	the	the	DT
cord-296585-yfh5d4io	339	35	NF	nf	NN
cord-296585-yfh5d4io	339	36	-	-	HYPH
cord-296585-yfh5d4io	339	37	κB	κb	CD
cord-296585-yfh5d4io	339	38	translocation	translocation	NN
cord-296585-yfh5d4io	339	39	-	-	HYPH
cord-296585-yfh5d4io	339	40	dependent	dependent	JJ
cord-296585-yfh5d4io	339	41	,	,	,
cord-296585-yfh5d4io	339	42	and	and	CC
cord-296585-yfh5d4io	339	43	-independent	-independent	JJ
cord-296585-yfh5d4io	339	44	pathways	pathway	NNS
cord-296585-yfh5d4io	339	45	(	(	-LRB-
cord-296585-yfh5d4io	339	46	242	242	CD
cord-296585-yfh5d4io	339	47	)	)	-RRB-
cord-296585-yfh5d4io	339	48	.	.	.
cord-296585-yfh5d4io	340	1	The	the	DT
cord-296585-yfh5d4io	340	2	NF	nf	NN
cord-296585-yfh5d4io	340	3	-	-	HYPH
cord-296585-yfh5d4io	340	4	κB	κb	CD
cord-296585-yfh5d4io	340	5	nuclear	nuclear	JJ
cord-296585-yfh5d4io	340	6	translocation	translocation	NN
cord-296585-yfh5d4io	340	7	-	-	HYPH
cord-296585-yfh5d4io	340	8	dependent	dependent	JJ
cord-296585-yfh5d4io	340	9	pathway	pathway	NN
cord-296585-yfh5d4io	340	10	requires	require	VBZ
cord-296585-yfh5d4io	340	11	activation	activation	NN
cord-296585-yfh5d4io	340	12	of	of	IN
cord-296585-yfh5d4io	340	13	NF	nf	NN
cord-296585-yfh5d4io	340	14	-	-	HYPH
cord-296585-yfh5d4io	340	15	κB	κB	NNP
cord-296585-yfh5d4io	340	16	-	-	HYPH
cord-296585-yfh5d4io	340	17	inducing	induce	VBG
cord-296585-yfh5d4io	340	18	kinase	kinase	VBD
cord-296585-yfh5d4io	340	19	IKK	IKK	NNP
cord-296585-yfh5d4io	340	20	complex	complex	NN
cord-296585-yfh5d4io	340	21	.	.	.
cord-296585-yfh5d4io	341	1	In	in	IN
cord-296585-yfh5d4io	341	2	the	the	DT
cord-296585-yfh5d4io	341	3	second	second	JJ
cord-296585-yfh5d4io	341	4	pathway	pathway	NN
cord-296585-yfh5d4io	341	5	,	,	,
cord-296585-yfh5d4io	341	6	the	the	DT
cord-296585-yfh5d4io	341	7	MKK3/6-p38	mkk3/6-p38	JJ
cord-296585-yfh5d4io	341	8	MAPK	MAPK	NNP
cord-296585-yfh5d4io	341	9	signaling	signal	VBG
cord-296585-yfh5d4io	341	10	cascade	cascade	NN
cord-296585-yfh5d4io	341	11	is	be	VBZ
cord-296585-yfh5d4io	341	12	recruited	recruit	VBN
cord-296585-yfh5d4io	341	13	for	for	IN
cord-296585-yfh5d4io	341	14	direct	direct	JJ
cord-296585-yfh5d4io	341	15	nuclear	nuclear	JJ
cord-296585-yfh5d4io	341	16	phosphorylation	phosphorylation	NN
cord-296585-yfh5d4io	341	17	,	,	,
cord-296585-yfh5d4io	341	18	and	and	CC
cord-296585-yfh5d4io	341	19	thus	thus	RB
cord-296585-yfh5d4io	341	20	activation	activation	NN
cord-296585-yfh5d4io	341	21	of	of	IN
cord-296585-yfh5d4io	341	22	NF	nf	NN
cord-296585-yfh5d4io	341	23	-	-	HYPH
cord-296585-yfh5d4io	341	24	κB.	κb.	JJ
cord-296585-yfh5d4io	342	1	The	the	DT
cord-296585-yfh5d4io	342	2	branching	branching	NN
cord-296585-yfh5d4io	342	3	of	of	IN
cord-296585-yfh5d4io	342	4	both	both	DT
cord-296585-yfh5d4io	342	5	pathways	pathway	NNS
cord-296585-yfh5d4io	342	6	may	may	MD
cord-296585-yfh5d4io	342	7	occur	occur	VB
cord-296585-yfh5d4io	342	8	at	at	IN
cord-296585-yfh5d4io	342	9	the	the	DT
cord-296585-yfh5d4io	342	10	TGF	TGF	NNP
cord-296585-yfh5d4io	342	11	-	-	HYPH
cord-296585-yfh5d4io	342	12	β	β	NN
cord-296585-yfh5d4io	342	13	activated	activate	VBD
cord-296585-yfh5d4io	342	14	kinase	kinase	NNP
cord-296585-yfh5d4io	342	15	1	1	CD
cord-296585-yfh5d4io	342	16	(	(	-LRB-
cord-296585-yfh5d4io	342	17	TAK1	TAK1	NNP
cord-296585-yfh5d4io	342	18	)	)	-RRB-
cord-296585-yfh5d4io	342	19	signaling	signal	VBG
cord-296585-yfh5d4io	342	20	junction	junction	NN
cord-296585-yfh5d4io	342	21	.	.	.
cord-296585-yfh5d4io	343	1	NTHi	NTHi	VBZ
cord-296585-yfh5d4io	343	2	stimulation	stimulation	NN
cord-296585-yfh5d4io	343	3	via	via	IN
cord-296585-yfh5d4io	343	4	TLR2	TLR2	NNP
cord-296585-yfh5d4io	343	5	and	and	CC
cord-296585-yfh5d4io	343	6	downstream	downstream	JJ
cord-296585-yfh5d4io	343	7	activation	activation	NN
cord-296585-yfh5d4io	343	8	of	of	IN
cord-296585-yfh5d4io	343	9	p38	p38	NNP
cord-296585-yfh5d4io	343	10	MAPK	MAPK	NNP
cord-296585-yfh5d4io	343	11	/	/	SYM
cord-296585-yfh5d4io	343	12	NF	nf	NN
cord-296585-yfh5d4io	343	13	-	-	HYPH
cord-296585-yfh5d4io	343	14	κB	κB	NNP
cord-296585-yfh5d4io	343	15	-	-	HYPH
cord-296585-yfh5d4io	343	16	dependent	dependent	JJ
cord-296585-yfh5d4io	343	17	pathways	pathway	NNS
cord-296585-yfh5d4io	343	18	result	result	VBP
cord-296585-yfh5d4io	343	19	in	in	IN
cord-296585-yfh5d4io	343	20	expression	expression	NN
cord-296585-yfh5d4io	343	21	of	of	IN
cord-296585-yfh5d4io	343	22	COX-2	cox-2	JJ
cord-296585-yfh5d4io	343	23	and	and	CC
cord-296585-yfh5d4io	343	24	prostaglandin	prostaglandin	NN
cord-296585-yfh5d4io	343	25	(	(	-LRB-
cord-296585-yfh5d4io	343	26	E2	e2	NN
cord-296585-yfh5d4io	343	27	)	)	-RRB-
cord-296585-yfh5d4io	344	1	(	(	-LRB-
cord-296585-yfh5d4io	344	2	PGE2	PGE2	NNP
cord-296585-yfh5d4io	344	3	)	)	-RRB-
cord-296585-yfh5d4io	344	4	that	that	WDT
cord-296585-yfh5d4io	344	5	promote	promote	VBP
cord-296585-yfh5d4io	344	6	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	344	7	responses	response	NNS
cord-296585-yfh5d4io	344	8	(	(	-LRB-
cord-296585-yfh5d4io	344	9	245	245	CD
cord-296585-yfh5d4io	344	10	)	)	-RRB-
cord-296585-yfh5d4io	344	11	.	.	.
cord-296585-yfh5d4io	345	1	TLR4	tlr4	JJ
cord-296585-yfh5d4io	345	2	stimulation	stimulation	NN
cord-296585-yfh5d4io	345	3	by	by	IN
cord-296585-yfh5d4io	345	4	NTHi	NTHi	NNP
cord-296585-yfh5d4io	345	5	LOS	LOS	NNP
cord-296585-yfh5d4io	345	6	also	also	RB
cord-296585-yfh5d4io	345	7	contributes	contribute	VBZ
cord-296585-yfh5d4io	345	8	to	to	IN
cord-296585-yfh5d4io	345	9	the	the	DT
cord-296585-yfh5d4io	345	10	activation	activation	NN
cord-296585-yfh5d4io	345	11	of	of	IN
cord-296585-yfh5d4io	345	12	NF	nf	NN
cord-296585-yfh5d4io	345	13	-	-	HYPH
cord-296585-yfh5d4io	345	14	κB	κB	NNP
cord-296585-yfh5d4io	345	15	via	via	IN
cord-296585-yfh5d4io	345	16	two	two	CD
cord-296585-yfh5d4io	345	17	signaling	signal	VBG
cord-296585-yfh5d4io	345	18	pathways	pathway	NNS
cord-296585-yfh5d4io	345	19	,	,	,
cord-296585-yfh5d4io	345	20	the	the	DT
cord-296585-yfh5d4io	345	21	primary	primary	JJ
cord-296585-yfh5d4io	345	22	activating	activate	VBG
cord-296585-yfh5d4io	345	23	pathway	pathway	NN
cord-296585-yfh5d4io	345	24	of	of	IN
cord-296585-yfh5d4io	345	25	MyD88	myd88	JJ
cord-296585-yfh5d4io	345	26	cascade	cascade	NN
cord-296585-yfh5d4io	345	27	and	and	CC
cord-296585-yfh5d4io	345	28	the	the	DT
cord-296585-yfh5d4io	345	29	alternative	alternative	JJ
cord-296585-yfh5d4io	345	30	pathway	pathway	NN
cord-296585-yfh5d4io	345	31	of	of	IN
cord-296585-yfh5d4io	345	32	Toll	Toll	NNP
cord-296585-yfh5d4io	345	33	/	/	SYM
cord-296585-yfh5d4io	345	34	IL-1R	il-1r	CD
cord-296585-yfh5d4io	345	35	domain	domain	NN
cord-296585-yfh5d4io	345	36	-	-	HYPH
cord-296585-yfh5d4io	345	37	containing	contain	VBG
cord-296585-yfh5d4io	345	38	adapter	adapter	NN
cord-296585-yfh5d4io	345	39	-	-	HYPH
cord-296585-yfh5d4io	345	40	inducing	induce	VBG
cord-296585-yfh5d4io	345	41	interferon	interferon	NN
cord-296585-yfh5d4io	345	42	-	-	HYPH
cord-296585-yfh5d4io	345	43	β	β	NN
cord-296585-yfh5d4io	345	44	(	(	-LRB-
cord-296585-yfh5d4io	345	45	TRIF	TRIF	NNP
cord-296585-yfh5d4io	345	46	)	)	-RRB-
cord-296585-yfh5d4io	345	47	.	.	.
cord-296585-yfh5d4io	346	1	Both	both	DT
cord-296585-yfh5d4io	346	2	pathways	pathway	NNS
cord-296585-yfh5d4io	346	3	activate	activate	VBP
cord-296585-yfh5d4io	346	4	NF	NF	NNP
cord-296585-yfh5d4io	346	5	-	-	HYPH
cord-296585-yfh5d4io	346	6	κB	κB	NNP
cord-296585-yfh5d4io	346	7	through	through	IN
cord-296585-yfh5d4io	346	8	phosphorylation	phosphorylation	NN
cord-296585-yfh5d4io	346	9	and	and	CC
cord-296585-yfh5d4io	346	10	degradation	degradation	NN
cord-296585-yfh5d4io	346	11	of	of	IN
cord-296585-yfh5d4io	346	12	inhibitor	inhibitor	NN
cord-296585-yfh5d4io	346	13	IκBα	IκBα	NNP
cord-296585-yfh5d4io	346	14	(	(	-LRB-
cord-296585-yfh5d4io	346	15	243	243	CD
cord-296585-yfh5d4io	346	16	,	,	,
cord-296585-yfh5d4io	346	17	246	246	CD
cord-296585-yfh5d4io	346	18	)	)	-RRB-
cord-296585-yfh5d4io	346	19	.	.	.
cord-296585-yfh5d4io	347	1	NTHi	NTHi	NNPS
cord-296585-yfh5d4io	347	2	-	-	HYPH
cord-296585-yfh5d4io	347	3	TLR4	TLR4	NNP
cord-296585-yfh5d4io	347	4	signaling	signaling	NN
cord-296585-yfh5d4io	347	5	mediates	mediate	VBZ
cord-296585-yfh5d4io	347	6	an	an	DT
cord-296585-yfh5d4io	347	7	effective	effective	JJ
cord-296585-yfh5d4io	347	8	innate	innate	JJ
cord-296585-yfh5d4io	347	9	immune	immune	JJ
cord-296585-yfh5d4io	347	10	response	response	NN
cord-296585-yfh5d4io	347	11	that	that	WDT
cord-296585-yfh5d4io	347	12	leads	lead	VBZ
cord-296585-yfh5d4io	347	13	to	to	IN
cord-296585-yfh5d4io	347	14	upregulation	upregulation	NN
cord-296585-yfh5d4io	347	15	of	of	IN
cord-296585-yfh5d4io	347	16	TNF	TNF	NNP
cord-296585-yfh5d4io	347	17	-	-	HYPH
cord-296585-yfh5d4io	347	18	α	α	NNP
cord-296585-yfh5d4io	347	19	,	,	,
cord-296585-yfh5d4io	347	20	IL-1β	IL-1β	NNP
cord-296585-yfh5d4io	347	21	,	,	,
cord-296585-yfh5d4io	347	22	IL-6	IL-6	NNP
cord-296585-yfh5d4io	347	23	,	,	,
cord-296585-yfh5d4io	347	24	macrophage	macrophage	NN
cord-296585-yfh5d4io	347	25	-	-	HYPH
cord-296585-yfh5d4io	347	26	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	347	27	protein	protein	NN
cord-296585-yfh5d4io	347	28	(	(	-LRB-
cord-296585-yfh5d4io	347	29	MIP)-1α	MIP)-1α	NNP
cord-296585-yfh5d4io	347	30	,	,	,
cord-296585-yfh5d4io	347	31	MIP-2	MIP-2	NNP
cord-296585-yfh5d4io	347	32	,	,	,
cord-296585-yfh5d4io	347	33	and	and	CC
cord-296585-yfh5d4io	347	34	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	347	35	infiltration	infiltration	NN
cord-296585-yfh5d4io	347	36	in	in	IN
cord-296585-yfh5d4io	347	37	the	the	DT
cord-296585-yfh5d4io	347	38	airways	airways	NNPS
cord-296585-yfh5d4io	347	39	of	of	IN
cord-296585-yfh5d4io	347	40	mice	mouse	NNS
cord-296585-yfh5d4io	347	41	.	.	.
cord-296585-yfh5d4io	348	1	The	the	DT
cord-296585-yfh5d4io	348	2	TLR4	TLR4	NNP
cord-296585-yfh5d4io	348	3	response	response	NN
cord-296585-yfh5d4io	348	4	promotes	promote	VBZ
cord-296585-yfh5d4io	348	5	efficient	efficient	JJ
cord-296585-yfh5d4io	348	6	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	348	7	clearance	clearance	NN
cord-296585-yfh5d4io	348	8	of	of	IN
cord-296585-yfh5d4io	348	9	bacteria	bacteria	NNS
cord-296585-yfh5d4io	348	10	in	in	IN
cord-296585-yfh5d4io	348	11	TLR4expressing	tlr4expresse	VBG
cord-296585-yfh5d4io	348	12	animals	animal	NNS
cord-296585-yfh5d4io	348	13	compared	compare	VBN
cord-296585-yfh5d4io	348	14	to	to	IN
cord-296585-yfh5d4io	348	15	CD14	CD14	NNP
cord-296585-yfh5d4io	348	16	/	/	SYM
cord-296585-yfh5d4io	348	17	TLR4	TLR4	NNP
cord-296585-yfh5d4io	348	18	knockout	knockout	NN
cord-296585-yfh5d4io	348	19	mice	mouse	NNS
cord-296585-yfh5d4io	348	20	(	(	-LRB-
cord-296585-yfh5d4io	348	21	243	243	CD
cord-296585-yfh5d4io	348	22	,	,	,
cord-296585-yfh5d4io	348	23	244	244	CD
cord-296585-yfh5d4io	348	24	)	)	-RRB-
cord-296585-yfh5d4io	348	25	.	.	.
cord-296585-yfh5d4io	349	1	A	a	DT
cord-296585-yfh5d4io	349	2	recent	recent	JJ
cord-296585-yfh5d4io	349	3	study	study	NN
cord-296585-yfh5d4io	349	4	by	by	IN
cord-296585-yfh5d4io	349	5	Jungnickel	Jungnickel	NNP
cord-296585-yfh5d4io	349	6	et	et	NNP
cord-296585-yfh5d4io	349	7	al	al	NNP
cord-296585-yfh5d4io	349	8	.	.	NNP
cord-296585-yfh5d4io	349	9	revealed	reveal	VBD
cord-296585-yfh5d4io	349	10	that	that	IN
cord-296585-yfh5d4io	349	11	,	,	,
cord-296585-yfh5d4io	349	12	in	in	IN
cord-296585-yfh5d4io	349	13	parallel	parallel	NN
cord-296585-yfh5d4io	349	14	with	with	IN
cord-296585-yfh5d4io	349	15	the	the	DT
cord-296585-yfh5d4io	349	16	infection	infection	NN
cord-296585-yfh5d4io	349	17	-	-	HYPH
cord-296585-yfh5d4io	349	18	induced	induce	VBN
cord-296585-yfh5d4io	349	19	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	349	20	neutrophilic	neutrophilic	JJ
cord-296585-yfh5d4io	349	21	inflammation	inflammation	NN
cord-296585-yfh5d4io	349	22	,	,	,
cord-296585-yfh5d4io	349	23	NTHi	NTHi	NNS
cord-296585-yfh5d4io	349	24	-	-	HYPH
cord-296585-yfh5d4io	349	25	dependent	dependent	JJ
cord-296585-yfh5d4io	349	26	stimulation	stimulation	NN
cord-296585-yfh5d4io	349	27	of	of	IN
cord-296585-yfh5d4io	349	28	both	both	CC
cord-296585-yfh5d4io	349	29	TLR2	TLR2	NNP
cord-296585-yfh5d4io	349	30	and	and	CC
cord-296585-yfh5d4io	349	31	TLR4	TLR4	NNP
cord-296585-yfh5d4io	349	32	in	in	IN
cord-296585-yfh5d4io	349	33	a	a	DT
cord-296585-yfh5d4io	349	34	transgenic	transgenic	JJ
cord-296585-yfh5d4io	349	35	mouse	mouse	NN
cord-296585-yfh5d4io	349	36	[	[	-LRB-
cord-296585-yfh5d4io	349	37	(	(	-LRB-
cord-296585-yfh5d4io	349	38	Kras	Kras	NNP
cord-296585-yfh5d4io	349	39	LA1	LA1	NNP
cord-296585-yfh5d4io	349	40	)	)	-RRB-
cord-296585-yfh5d4io	349	41	with	with	IN
cord-296585-yfh5d4io	349	42	oncogenic	oncogenic	JJ
cord-296585-yfh5d4io	349	43	Kras	Kras	NNP
cord-296585-yfh5d4io	349	44	allele	allele	NN
cord-296585-yfh5d4io	349	45	in	in	IN
cord-296585-yfh5d4io	349	46	the	the	DT
cord-296585-yfh5d4io	349	47	lung	lung	NN
cord-296585-yfh5d4io	349	48	epithelium	epithelium	NN
cord-296585-yfh5d4io	349	49	]	]	-RRB-
cord-296585-yfh5d4io	349	50	additionally	additionally	RB
cord-296585-yfh5d4io	349	51	promotes	promote	VBZ
cord-296585-yfh5d4io	349	52	the	the	DT
cord-296585-yfh5d4io	349	53	proliferation	proliferation	NN
cord-296585-yfh5d4io	349	54	of	of	IN
cord-296585-yfh5d4io	349	55	Kras	Kras	NNP
cord-296585-yfh5d4io	349	56	-	-	HYPH
cord-296585-yfh5d4io	349	57	induced	induce	VBN
cord-296585-yfh5d4io	349	58	early	early	JJ
cord-296585-yfh5d4io	349	59	adenomatous	adenomatous	JJ
cord-296585-yfh5d4io	349	60	lesion	lesion	NN
cord-296585-yfh5d4io	349	61	in	in	IN
cord-296585-yfh5d4io	349	62	the	the	DT
cord-296585-yfh5d4io	349	63	lung	lung	NN
cord-296585-yfh5d4io	349	64	in	in	IN
cord-296585-yfh5d4io	349	65	an	an	DT
cord-296585-yfh5d4io	349	66	TLR	tlr	NN
cord-296585-yfh5d4io	349	67	-	-	HYPH
cord-296585-yfh5d4io	349	68	dependent	dependent	JJ
cord-296585-yfh5d4io	349	69	manner	manner	NN
cord-296585-yfh5d4io	349	70	(	(	-LRB-
cord-296585-yfh5d4io	349	71	247	247	CD
cord-296585-yfh5d4io	349	72	)	)	-RRB-
cord-296585-yfh5d4io	349	73	.	.	.
cord-296585-yfh5d4io	350	1	The	the	DT
cord-296585-yfh5d4io	350	2	association	association	NN
cord-296585-yfh5d4io	350	3	or	or	CC
cord-296585-yfh5d4io	350	4	role	role	NN
cord-296585-yfh5d4io	350	5	of	of	IN
cord-296585-yfh5d4io	350	6	NTHi	NTHi	NNS
cord-296585-yfh5d4io	350	7	-	-	HYPH
cord-296585-yfh5d4io	350	8	induced	induce	VBN
cord-296585-yfh5d4io	350	9	airway	airway	JJ
cord-296585-yfh5d4io	350	10	inflammation	inflammation	NN
cord-296585-yfh5d4io	350	11	in	in	IN
cord-296585-yfh5d4io	350	12	lung	lung	NN
cord-296585-yfh5d4io	350	13	cancer	cancer	NN
cord-296585-yfh5d4io	350	14	progression	progression	NN
cord-296585-yfh5d4io	350	15	,	,	,
cord-296585-yfh5d4io	350	16	however	however	RB
cord-296585-yfh5d4io	350	17	,	,	,
cord-296585-yfh5d4io	350	18	is	be	VBZ
cord-296585-yfh5d4io	350	19	not	not	RB
cord-296585-yfh5d4io	350	20	supported	support	VBN
cord-296585-yfh5d4io	350	21	by	by	IN
cord-296585-yfh5d4io	350	22	another	another	DT
cord-296585-yfh5d4io	350	23	recent	recent	JJ
cord-296585-yfh5d4io	350	24	cohort	cohort	NN
cord-296585-yfh5d4io	350	25	study	study	NN
cord-296585-yfh5d4io	350	26	showing	show	VBG
cord-296585-yfh5d4io	350	27	the	the	DT
cord-296585-yfh5d4io	350	28	lack	lack	NN
cord-296585-yfh5d4io	350	29	of	of	IN
cord-296585-yfh5d4io	350	30	differences	difference	NNS
cord-296585-yfh5d4io	350	31	in	in	IN
cord-296585-yfh5d4io	350	32	NTHi	nthi	JJ
cord-296585-yfh5d4io	350	33	specific	specific	JJ
cord-296585-yfh5d4io	350	34	-	-	HYPH
cord-296585-yfh5d4io	350	35	antibodies	antibody	NNS
cord-296585-yfh5d4io	350	36	between	between	IN
cord-296585-yfh5d4io	350	37	cancer	cancer	NN
cord-296585-yfh5d4io	350	38	-	-	HYPH
cord-296585-yfh5d4io	350	39	and	and	CC
cord-296585-yfh5d4io	350	40	non	non	JJ
cord-296585-yfh5d4io	350	41	-	-	JJ
cord-296585-yfh5d4io	350	42	cancer	cancer	JJ
cord-296585-yfh5d4io	350	43	COPD	COPD	NNP
cord-296585-yfh5d4io	350	44	patients	patient	NNS
cord-296585-yfh5d4io	350	45	(	(	-LRB-
cord-296585-yfh5d4io	350	46	12	12	CD
cord-296585-yfh5d4io	350	47	)	)	-RRB-
cord-296585-yfh5d4io	350	48	.	.	.
cord-296585-yfh5d4io	351	1	Lastly	lastly	RB
cord-296585-yfh5d4io	351	2	,	,	,
cord-296585-yfh5d4io	351	3	Dectin-1	Dectin-1	NNP
cord-296585-yfh5d4io	351	4	and	and	CC
cord-296585-yfh5d4io	351	5	the	the	DT
cord-296585-yfh5d4io	351	6	epidermal	epidermal	JJ
cord-296585-yfh5d4io	351	7	growth	growth	NN
cord-296585-yfh5d4io	351	8	factor	factor	NN
cord-296585-yfh5d4io	351	9	receptor	receptor	NN
cord-296585-yfh5d4io	351	10	(	(	-LRB-
cord-296585-yfh5d4io	351	11	EFGR	EFGR	NNP
cord-296585-yfh5d4io	351	12	)	)	-RRB-
cord-296585-yfh5d4io	351	13	pathway	pathway	NN
cord-296585-yfh5d4io	351	14	also	also	RB
cord-296585-yfh5d4io	351	15	have	have	VBP
cord-296585-yfh5d4io	351	16	proinflammtory	proinflammtory	NN
cord-296585-yfh5d4io	351	17	effects	effect	NNS
cord-296585-yfh5d4io	351	18	upon	upon	IN
cord-296585-yfh5d4io	351	19	interaction	interaction	NN
cord-296585-yfh5d4io	351	20	with	with	IN
cord-296585-yfh5d4io	351	21	NTHi	NTHi	NNS
cord-296585-yfh5d4io	351	22	(	(	-LRB-
cord-296585-yfh5d4io	351	23	248	248	CD
cord-296585-yfh5d4io	351	24	,	,	,
cord-296585-yfh5d4io	351	25	249	249	CD
cord-296585-yfh5d4io	351	26	)	)	-RRB-
cord-296585-yfh5d4io	351	27	.	.	.
cord-296585-yfh5d4io	352	1	Activation	activation	NN
cord-296585-yfh5d4io	352	2	of	of	IN
cord-296585-yfh5d4io	352	3	the	the	DT
cord-296585-yfh5d4io	352	4	Dectindependent	Dectindependent	NNP
cord-296585-yfh5d4io	352	5	proinflammatory	proinflammatory	JJ
cord-296585-yfh5d4io	352	6	response	response	NN
cord-296585-yfh5d4io	352	7	requires	require	VBZ
cord-296585-yfh5d4io	352	8	NTHi	NTHi	NNS
cord-296585-yfh5d4io	352	9	-	-	HYPH
cord-296585-yfh5d4io	352	10	induced	induce	VBN
cord-296585-yfh5d4io	352	11	phosphorylation	phosphorylation	NN
cord-296585-yfh5d4io	352	12	of	of	IN
cord-296585-yfh5d4io	352	13	the	the	DT
cord-296585-yfh5d4io	352	14	Dectin-1	Dectin-1	NNP
cord-296585-yfh5d4io	352	15	hem	hem	NNP
cord-296585-yfh5d4io	352	16	-	-	HYPH
cord-296585-yfh5d4io	352	17	immunoreceptor	immunoreceptor	NNP
cord-296585-yfh5d4io	352	18	tyrosinebased	tyrosinebased	JJ
cord-296585-yfh5d4io	352	19	activation	activation	NN
cord-296585-yfh5d4io	352	20	motif	motif	NN
cord-296585-yfh5d4io	352	21	(	(	-LRB-
cord-296585-yfh5d4io	352	22	hemITAM	hemitam	ADD
cord-296585-yfh5d4io	352	23	)	)	-RRB-
cord-296585-yfh5d4io	352	24	(	(	-LRB-
cord-296585-yfh5d4io	352	25	248	248	CD
cord-296585-yfh5d4io	352	26	)	)	-RRB-
cord-296585-yfh5d4io	352	27	.	.	.
cord-296585-yfh5d4io	353	1	Direct	direct	JJ
cord-296585-yfh5d4io	353	2	activation	activation	NN
cord-296585-yfh5d4io	353	3	of	of	IN
cord-296585-yfh5d4io	353	4	EFGR	EFGR	NNS
cord-296585-yfh5d4io	353	5	in	in	IN
cord-296585-yfh5d4io	353	6	alveolar	alveolar	JJ
cord-296585-yfh5d4io	353	7	cells	cell	NNS
cord-296585-yfh5d4io	353	8	and	and	CC
cord-296585-yfh5d4io	353	9	HMEE	HMEE	NNP
cord-296585-yfh5d4io	353	10	by	by	IN
cord-296585-yfh5d4io	353	11	NTHi	NTHi	NNS
cord-296585-yfh5d4io	353	12	-	-	HYPH
cord-296585-yfh5d4io	353	13	derived	derive	VBN
cord-296585-yfh5d4io	353	14	EGFlike	egflike	NN
cord-296585-yfh5d4io	353	15	factor	factor	NN
cord-296585-yfh5d4io	353	16	has	have	VBZ
cord-296585-yfh5d4io	353	17	been	be	VBN
cord-296585-yfh5d4io	353	18	shown	show	VBN
cord-296585-yfh5d4io	353	19	to	to	TO
cord-296585-yfh5d4io	353	20	contribute	contribute	VB
cord-296585-yfh5d4io	353	21	to	to	IN
cord-296585-yfh5d4io	353	22	NF	nf	NN
cord-296585-yfh5d4io	353	23	-	-	HYPH
cord-296585-yfh5d4io	353	24	κB	κb	CD
cord-296585-yfh5d4io	353	25	activation	activation	NN
cord-296585-yfh5d4io	353	26	.	.	.
cord-296585-yfh5d4io	354	1	The	the	DT
cord-296585-yfh5d4io	354	2	EFGR	efgr	NN
cord-296585-yfh5d4io	354	3	-	-	HYPH
cord-296585-yfh5d4io	354	4	dependent	dependent	JJ
cord-296585-yfh5d4io	354	5	NF	nf	NN
cord-296585-yfh5d4io	354	6	-	-	HYPH
cord-296585-yfh5d4io	354	7	κB	κb	CD
cord-296585-yfh5d4io	354	8	activation	activation	NN
cord-296585-yfh5d4io	354	9	is	be	VBZ
cord-296585-yfh5d4io	354	10	mediated	mediate	VBN
cord-296585-yfh5d4io	354	11	via	via	IN
cord-296585-yfh5d4io	354	12	an	an	DT
cord-296585-yfh5d4io	354	13	NF	nf	NN
cord-296585-yfh5d4io	354	14	-	-	HYPH
cord-296585-yfh5d4io	354	15	κB	κb	CD
cord-296585-yfh5d4io	354	16	nuclear	nuclear	JJ
cord-296585-yfh5d4io	354	17	translocation	translocation	NN
cord-296585-yfh5d4io	354	18	-	-	HYPH
cord-296585-yfh5d4io	354	19	independent	independent	JJ
cord-296585-yfh5d4io	354	20	pathway	pathway	NN
cord-296585-yfh5d4io	354	21	,	,	,
cord-296585-yfh5d4io	354	22	which	which	WDT
cord-296585-yfh5d4io	354	23	involves	involve	VBZ
cord-296585-yfh5d4io	354	24	both	both	CC
cord-296585-yfh5d4io	354	25	MKK3/6-p38	mkk3/6-p38	JJ
cord-296585-yfh5d4io	354	26	and	and	CC
cord-296585-yfh5d4io	354	27	PI3K	PI3K	NNP
cord-296585-yfh5d4io	354	28	/	/	SYM
cord-296585-yfh5d4io	354	29	Akt	Akt	NNP
cord-296585-yfh5d4io	354	30	signaling	signal	VBG
cord-296585-yfh5d4io	354	31	pathways	pathway	NNS
cord-296585-yfh5d4io	354	32	(	(	-LRB-
cord-296585-yfh5d4io	354	33	249	249	CD
cord-296585-yfh5d4io	354	34	)	)	-RRB-
cord-296585-yfh5d4io	354	35	.	.	.
cord-296585-yfh5d4io	355	1	Surprisingly	surprisingly	RB
cord-296585-yfh5d4io	355	2	,	,	,
cord-296585-yfh5d4io	355	3	the	the	DT
cord-296585-yfh5d4io	355	4	interaction	interaction	NN
cord-296585-yfh5d4io	355	5	of	of	IN
cord-296585-yfh5d4io	355	6	EFGR	EFGR	NNS
cord-296585-yfh5d4io	355	7	and	and	CC
cord-296585-yfh5d4io	355	8	NTHi	NTHi	NNS
cord-296585-yfh5d4io	355	9	also	also	RB
cord-296585-yfh5d4io	355	10	results	result	VBZ
cord-296585-yfh5d4io	355	11	in	in	IN
cord-296585-yfh5d4io	355	12	negative	negative	JJ
cord-296585-yfh5d4io	355	13	regulation	regulation	NN
cord-296585-yfh5d4io	355	14	and	and	CC
cord-296585-yfh5d4io	355	15	suppression	suppression	NN
cord-296585-yfh5d4io	355	16	of	of	IN
cord-296585-yfh5d4io	355	17	the	the	DT
cord-296585-yfh5d4io	355	18	induction	induction	NN
cord-296585-yfh5d4io	355	19	of	of	IN
cord-296585-yfh5d4io	355	20	TLR2	TLR2	NNP
cord-296585-yfh5d4io	355	21	via	via	IN
cord-296585-yfh5d4io	355	22	the	the	DT
cord-296585-yfh5d4io	355	23	Src	Src	NNP
cord-296585-yfh5d4io	355	24	-	-	HYPH
cord-296585-yfh5d4io	355	25	MKK3/6-p38	MKK3/6-p38	NNP
cord-296585-yfh5d4io	355	26	α	α	NNP
cord-296585-yfh5d4io	355	27	/	/	SYM
cord-296585-yfh5d4io	355	28	β	β	NN
cord-296585-yfh5d4io	355	29	MAP	MAP	NNP
cord-296585-yfh5d4io	355	30	kinase	kinase	NN
cord-296585-yfh5d4io	355	31	-	-	HYPH
cord-296585-yfh5d4io	355	32	dependent	dependent	JJ
cord-296585-yfh5d4io	355	33	signaling	signal	VBG
cord-296585-yfh5d4io	355	34	cascade	cascade	NN
cord-296585-yfh5d4io	355	35	,	,	,
cord-296585-yfh5d4io	355	36	and	and	CC
cord-296585-yfh5d4io	355	37	this	this	DT
cord-296585-yfh5d4io	355	38	in	in	IN
cord-296585-yfh5d4io	355	39	turn	turn	NN
cord-296585-yfh5d4io	355	40	may	may	MD
cord-296585-yfh5d4io	355	41	facilitate	facilitate	VB
cord-296585-yfh5d4io	355	42	NTHi	nthi	JJ
cord-296585-yfh5d4io	355	43	infection	infection	NN
cord-296585-yfh5d4io	355	44	(	(	-LRB-
cord-296585-yfh5d4io	355	45	250	250	CD
cord-296585-yfh5d4io	355	46	)	)	-RRB-
cord-296585-yfh5d4io	355	47	.	.	.
cord-296585-yfh5d4io	356	1	The	the	DT
cord-296585-yfh5d4io	356	2	actual	actual	JJ
cord-296585-yfh5d4io	356	3	components	component	NNS
cord-296585-yfh5d4io	356	4	of	of	IN
cord-296585-yfh5d4io	356	5	NTHi	NTHi	NNS
cord-296585-yfh5d4io	356	6	that	that	WDT
cord-296585-yfh5d4io	356	7	exhibit	exhibit	VBP
cord-296585-yfh5d4io	356	8	the	the	DT
cord-296585-yfh5d4io	356	9	EGF	EGF	NNP
cord-296585-yfh5d4io	356	10	-	-	HYPH
cord-296585-yfh5d4io	356	11	like	like	JJ
cord-296585-yfh5d4io	356	12	factor	factor	NN
cord-296585-yfh5d4io	356	13	activity	activity	NN
cord-296585-yfh5d4io	356	14	have	have	VBP
cord-296585-yfh5d4io	356	15	,	,	,
cord-296585-yfh5d4io	356	16	however	however	RB
cord-296585-yfh5d4io	356	17	,	,	,
cord-296585-yfh5d4io	356	18	yet	yet	RB
cord-296585-yfh5d4io	356	19	to	to	TO
cord-296585-yfh5d4io	356	20	be	be	VB
cord-296585-yfh5d4io	356	21	defined	define	VBN
cord-296585-yfh5d4io	356	22	.	.	.
cord-296585-yfh5d4io	357	1	The	the	DT
cord-296585-yfh5d4io	357	2	EFGRdependent	efgrdependent	NN
cord-296585-yfh5d4io	357	3	negative	negative	JJ
cord-296585-yfh5d4io	357	4	regulation	regulation	NN
cord-296585-yfh5d4io	357	5	of	of	IN
cord-296585-yfh5d4io	357	6	TLR2	TLR2	NNP
cord-296585-yfh5d4io	357	7	may	may	MD
cord-296585-yfh5d4io	357	8	thus	thus	RB
cord-296585-yfh5d4io	357	9	suggest	suggest	VB
cord-296585-yfh5d4io	357	10	a	a	DT
cord-296585-yfh5d4io	357	11	novel	novel	JJ
cord-296585-yfh5d4io	357	12	mechanism	mechanism	NN
cord-296585-yfh5d4io	357	13	targeted	target	VBN
cord-296585-yfh5d4io	357	14	by	by	IN
cord-296585-yfh5d4io	357	15	NTHi	NTHi	NNS
cord-296585-yfh5d4io	357	16	for	for	IN
cord-296585-yfh5d4io	357	17	immune	immune	JJ
cord-296585-yfh5d4io	357	18	evasion	evasion	NN
cord-296585-yfh5d4io	357	19	by	by	IN
cord-296585-yfh5d4io	357	20	attenuating	attenuate	VBG
cord-296585-yfh5d4io	357	21	the	the	DT
cord-296585-yfh5d4io	357	22	responses	response	NNS
cord-296585-yfh5d4io	357	23	of	of	IN
cord-296585-yfh5d4io	357	24	host	host	NN
cord-296585-yfh5d4io	357	25	PRR	PRR	NNP
cord-296585-yfh5d4io	357	26	,	,	,
cord-296585-yfh5d4io	357	27	despite	despite	IN
cord-296585-yfh5d4io	357	28	the	the	DT
cord-296585-yfh5d4io	357	29	contradicted	contradict	VBN
cord-296585-yfh5d4io	357	30	role	role	NN
cord-296585-yfh5d4io	357	31	of	of	IN
cord-296585-yfh5d4io	357	32	EFGR	EFGR	NNS
cord-296585-yfh5d4io	357	33	in	in	IN
cord-296585-yfh5d4io	357	34	proinflammatory	proinflammatory	JJ
cord-296585-yfh5d4io	357	35	and	and	CC
cord-296585-yfh5d4io	357	36	innate	innate	JJ
cord-296585-yfh5d4io	357	37	immune	immune	JJ
cord-296585-yfh5d4io	357	38	responses	response	NNS
cord-296585-yfh5d4io	357	39	of	of	IN
cord-296585-yfh5d4io	357	40	the	the	DT
cord-296585-yfh5d4io	357	41	airway	airway	NN
cord-296585-yfh5d4io	357	42	epithelium	epithelium	NN
cord-296585-yfh5d4io	357	43	(	(	-LRB-
cord-296585-yfh5d4io	357	44	251	251	CD
cord-296585-yfh5d4io	357	45	)	)	-RRB-
cord-296585-yfh5d4io	357	46	.	.	.
cord-296585-yfh5d4io	358	1	NTHi	NTHi	NNP
cord-296585-yfh5d4io	358	2	infection	infection	NN
cord-296585-yfh5d4io	358	3	also	also	RB
cord-296585-yfh5d4io	358	4	upregulates	upregulate	VBZ
cord-296585-yfh5d4io	358	5	the	the	DT
cord-296585-yfh5d4io	358	6	NRLP3-inflammasome	NRLP3-inflammasome	NNP
cord-296585-yfh5d4io	358	7	during	during	IN
cord-296585-yfh5d4io	358	8	NTHi	NTHi	NNS
cord-296585-yfh5d4io	358	9	-	-	HYPH
cord-296585-yfh5d4io	358	10	induced	induce	VBN
cord-296585-yfh5d4io	358	11	inflammation	inflammation	NN
cord-296585-yfh5d4io	358	12	in	in	IN
cord-296585-yfh5d4io	358	13	the	the	DT
cord-296585-yfh5d4io	358	14	airway	airway	NN
cord-296585-yfh5d4io	358	15	epithelium	epithelium	NN
cord-296585-yfh5d4io	358	16	and	and	CC
cord-296585-yfh5d4io	358	17	alveolar	alveolar	JJ
cord-296585-yfh5d4io	358	18	macrophages	macrophage	NNS
cord-296585-yfh5d4io	358	19	,	,	,
cord-296585-yfh5d4io	358	20	leading	lead	VBG
cord-296585-yfh5d4io	358	21	to	to	IN
cord-296585-yfh5d4io	358	22	increased	increase	VBN
cord-296585-yfh5d4io	358	23	secretion	secretion	NN
cord-296585-yfh5d4io	358	24	of	of	IN
cord-296585-yfh5d4io	358	25	IL-1β	il-1β	NN
cord-296585-yfh5d4io	358	26	and	and	CC
cord-296585-yfh5d4io	358	27	IL-8	IL-8	NNP
cord-296585-yfh5d4io	358	28	,	,	,
cord-296585-yfh5d4io	358	29	and	and	CC
cord-296585-yfh5d4io	358	30	thus	thus	RB
cord-296585-yfh5d4io	358	31	neutrophilic	neutrophilic	JJ
cord-296585-yfh5d4io	358	32	influx	influx	NN
cord-296585-yfh5d4io	358	33	to	to	IN
cord-296585-yfh5d4io	358	34	the	the	DT
cord-296585-yfh5d4io	358	35	lung	lung	NN
cord-296585-yfh5d4io	358	36	(	(	-LRB-
cord-296585-yfh5d4io	358	37	252	252	CD
cord-296585-yfh5d4io	358	38	)	)	-RRB-
cord-296585-yfh5d4io	358	39	.	.	.
cord-296585-yfh5d4io	359	1	Some	some	DT
cord-296585-yfh5d4io	359	2	of	of	IN
cord-296585-yfh5d4io	359	3	the	the	DT
cord-296585-yfh5d4io	359	4	endogenous	endogenous	JJ
cord-296585-yfh5d4io	359	5	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	359	6	mediators	mediator	NNS
cord-296585-yfh5d4io	359	7	that	that	WDT
cord-296585-yfh5d4io	359	8	are	be	VBP
cord-296585-yfh5d4io	359	9	produced	produce	VBN
cord-296585-yfh5d4io	359	10	in	in	IN
cord-296585-yfh5d4io	359	11	response	response	NN
cord-296585-yfh5d4io	359	12	to	to	IN
cord-296585-yfh5d4io	359	13	NTHi	NTHi	NNS
cord-296585-yfh5d4io	359	14	infection	infection	NN
cord-296585-yfh5d4io	359	15	,	,	,
cord-296585-yfh5d4io	359	16	including	include	VBG
cord-296585-yfh5d4io	359	17	TNF	TNF	NNP
cord-296585-yfh5d4io	359	18	-	-	HYPH
cord-296585-yfh5d4io	359	19	α	α	NNP
cord-296585-yfh5d4io	359	20	,	,	,
cord-296585-yfh5d4io	359	21	IL-1α	il-1α	NN
cord-296585-yfh5d4io	359	22	,	,	,
cord-296585-yfh5d4io	359	23	and	and	CC
cord-296585-yfh5d4io	359	24	TGF	TGF	NNP
cord-296585-yfh5d4io	359	25	-	-	HYPH
cord-296585-yfh5d4io	359	26	β1	β1	NNP
cord-296585-yfh5d4io	359	27	,	,	,
cord-296585-yfh5d4io	359	28	may	may	MD
cord-296585-yfh5d4io	359	29	act	act	VB
cord-296585-yfh5d4io	359	30	synergetically	synergetically	RB
cord-296585-yfh5d4io	359	31	with	with	IN
cord-296585-yfh5d4io	359	32	NTHi	NTHi	NNS
cord-296585-yfh5d4io	359	33	on	on	IN
cord-296585-yfh5d4io	359	34	the	the	DT
cord-296585-yfh5d4io	359	35	airway	airway	NN
cord-296585-yfh5d4io	359	36	epithelial	epithelial	NN
cord-296585-yfh5d4io	359	37	and	and	CC
cord-296585-yfh5d4io	359	38	immune	immune	JJ
cord-296585-yfh5d4io	359	39	cells	cell	NNS
cord-296585-yfh5d4io	359	40	.	.	.
cord-296585-yfh5d4io	360	1	The	the	DT
cord-296585-yfh5d4io	360	2	synergetic	synergetic	JJ
cord-296585-yfh5d4io	360	3	interaction	interaction	NN
cord-296585-yfh5d4io	360	4	drives	drive	VBZ
cord-296585-yfh5d4io	360	5	a	a	DT
cord-296585-yfh5d4io	360	6	positive	positive	JJ
cord-296585-yfh5d4io	360	7	feedback	feedback	NN
cord-296585-yfh5d4io	360	8	loop	loop	NN
cord-296585-yfh5d4io	360	9	to	to	TO
cord-296585-yfh5d4io	360	10	amplify	amplify	VB
cord-296585-yfh5d4io	360	11	the	the	DT
cord-296585-yfh5d4io	360	12	NF	nf	NN
cord-296585-yfh5d4io	360	13	-	-	HYPH
cord-296585-yfh5d4io	360	14	κB	κb	CD
cord-296585-yfh5d4io	360	15	transcriptional	transcriptional	JJ
cord-296585-yfh5d4io	360	16	activity	activity	NN
cord-296585-yfh5d4io	360	17	on	on	IN
cord-296585-yfh5d4io	360	18	proinflammatory	proinflammatory	JJ
cord-296585-yfh5d4io	360	19	genes	gene	NNS
cord-296585-yfh5d4io	360	20	and	and	CC
cord-296585-yfh5d4io	360	21	further	further	RB
cord-296585-yfh5d4io	360	22	augments	augment	VBZ
cord-296585-yfh5d4io	360	23	airway	airway	NN
cord-296585-yfh5d4io	360	24	inflammation	inflammation	NN
cord-296585-yfh5d4io	360	25	.	.	.
cord-296585-yfh5d4io	361	1	The	the	DT
cord-296585-yfh5d4io	361	2	synergetic	synergetic	JJ
cord-296585-yfh5d4io	361	3	activation	activation	NN
cord-296585-yfh5d4io	361	4	of	of	IN
cord-296585-yfh5d4io	361	5	NF	nf	NN
cord-296585-yfh5d4io	361	6	-	-	HYPH
cord-296585-yfh5d4io	361	7	κB	κB	NNP
cord-296585-yfh5d4io	361	8	by	by	IN
cord-296585-yfh5d4io	361	9	NTHi	NTHi	NNS
cord-296585-yfh5d4io	361	10	and	and	CC
cord-296585-yfh5d4io	361	11	TNF	TNF	NNP
cord-296585-yfh5d4io	361	12	-	-	HYPH
cord-296585-yfh5d4io	361	13	α	α	NN
cord-296585-yfh5d4io	361	14	in	in	IN
cord-296585-yfh5d4io	361	15	HMEE	HMEE	NNP
cord-296585-yfh5d4io	361	16	and	and	CC
cord-296585-yfh5d4io	361	17	normal	normal	JJ
cord-296585-yfh5d4io	361	18	human	human	JJ
cord-296585-yfh5d4io	361	19	bronchial	bronchial	JJ
cord-296585-yfh5d4io	361	20	epithelial	epithelial	NN
cord-296585-yfh5d4io	361	21	(	(	-LRB-
cord-296585-yfh5d4io	361	22	NHBE	NHBE	NNP
cord-296585-yfh5d4io	361	23	)	)	-RRB-
cord-296585-yfh5d4io	361	24	cells	cell	NNS
cord-296585-yfh5d4io	361	25	occurs	occur	VBZ
cord-296585-yfh5d4io	361	26	via	via	IN
cord-296585-yfh5d4io	361	27	NF	nf	NN
cord-296585-yfh5d4io	361	28	-	-	HYPH
cord-296585-yfh5d4io	361	29	κB	κb	CD
cord-296585-yfh5d4io	361	30	nuclear	nuclear	JJ
cord-296585-yfh5d4io	361	31	translocation	translocation	NN
cord-296585-yfh5d4io	361	32	-	-	HYPH
cord-296585-yfh5d4io	361	33	dependent	dependent	JJ
cord-296585-yfh5d4io	361	34	and	and	CC
cord-296585-yfh5d4io	361	35	independent	independent	JJ
cord-296585-yfh5d4io	361	36	pathways	pathway	NNS
cord-296585-yfh5d4io	361	37	.	.	.
cord-296585-yfh5d4io	362	1	The	the	DT
cord-296585-yfh5d4io	362	2	latter	latter	JJ
cord-296585-yfh5d4io	362	3	pathway	pathway	NN
cord-296585-yfh5d4io	362	4	involves	involve	VBZ
cord-296585-yfh5d4io	362	5	MAPK	MAPK	NNP
cord-296585-yfh5d4io	362	6	/	/	SYM
cord-296585-yfh5d4io	362	7	extracellular	extracellular	JJ
cord-296585-yfh5d4io	362	8	signal	signal	NN
cord-296585-yfh5d4io	362	9	regulated	regulate	VBN
cord-296585-yfh5d4io	362	10	kinase	kinase	NN
cord-296585-yfh5d4io	362	11	kinase	kinase	NN
cord-296585-yfh5d4io	362	12	kinase	kinase	VBZ
cord-296585-yfh5d4io	362	13	1	1	CD
cord-296585-yfh5d4io	362	14	(	(	-LRB-
cord-296585-yfh5d4io	362	15	MEKK1)-dependent	MEKK1)-dependent	NNP
cord-296585-yfh5d4io	362	16	activation	activation	NN
cord-296585-yfh5d4io	362	17	of	of	IN
cord-296585-yfh5d4io	362	18	MAPK	MAPK	NNP
cord-296585-yfh5d4io	362	19	kinase	kinase	VBZ
cord-296585-yfh5d4io	362	20	3/6-p38	3/6-p38	NNP
cord-296585-yfh5d4io	362	21	MAPK	MAPK	NNP
cord-296585-yfh5d4io	362	22	pathway	pathway	NN
cord-296585-yfh5d4io	362	23	(	(	-LRB-
cord-296585-yfh5d4io	362	24	253	253	CD
cord-296585-yfh5d4io	362	25	)	)	-RRB-
cord-296585-yfh5d4io	362	26	.	.	.
cord-296585-yfh5d4io	363	1	However	however	RB
cord-296585-yfh5d4io	363	2	,	,	,
cord-296585-yfh5d4io	363	3	the	the	DT
cord-296585-yfh5d4io	363	4	synergetic	synergetic	JJ
cord-296585-yfh5d4io	363	5	action	action	NN
cord-296585-yfh5d4io	363	6	of	of	IN
cord-296585-yfh5d4io	363	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	363	8	with	with	IN
cord-296585-yfh5d4io	363	9	TGF	TGF	NNP
cord-296585-yfh5d4io	363	10	-	-	HYPH
cord-296585-yfh5d4io	363	11	β1	β1	NNP
cord-296585-yfh5d4io	363	12	is	be	VBZ
cord-296585-yfh5d4io	363	13	mediated	mediate	VBN
cord-296585-yfh5d4io	363	14	by	by	IN
cord-296585-yfh5d4io	363	15	another	another	DT
cord-296585-yfh5d4io	363	16	mechanism	mechanism	NN
cord-296585-yfh5d4io	363	17	which	which	WDT
cord-296585-yfh5d4io	363	18	involves	involve	VBZ
cord-296585-yfh5d4io	363	19	Smad3/4-protein	Smad3/4-protein	NNP
cord-296585-yfh5d4io	363	20	kinase	kinase	NNP
cord-296585-yfh5d4io	363	21	A	a	NN
cord-296585-yfh5d4io	363	22	(	(	-LRB-
cord-296585-yfh5d4io	364	1	PKA)-p300-dependent	pka)-p300-dependent	NN
cord-296585-yfh5d4io	364	2	signaling	signal	VBG
cord-296585-yfh5d4io	364	3	cascade	cascade	NN
cord-296585-yfh5d4io	364	4	.	.	.
cord-296585-yfh5d4io	365	1	The	the	DT
cord-296585-yfh5d4io	365	2	pathway	pathway	NN
cord-296585-yfh5d4io	365	3	components	component	NNS
cord-296585-yfh5d4io	365	4	,	,	,
cord-296585-yfh5d4io	365	5	PKA	PKA	NNP
cord-296585-yfh5d4io	365	6	and	and	CC
cord-296585-yfh5d4io	365	7	p300	p300	NNP
cord-296585-yfh5d4io	365	8	,	,	,
cord-296585-yfh5d4io	365	9	phosphorylates	phosphorylate	VBZ
cord-296585-yfh5d4io	365	10	residue	residue	NN
cord-296585-yfh5d4io	365	11	Ser276	Ser276	NNP
cord-296585-yfh5d4io	365	12	and	and	CC
cord-296585-yfh5d4io	365	13	acetylates	acetylates	NNP
cord-296585-yfh5d4io	365	14	Lys221	Lys221	,
cord-296585-yfh5d4io	365	15	of	of	IN
cord-296585-yfh5d4io	365	16	the	the	DT
cord-296585-yfh5d4io	365	17	NF	NF	NNP
cord-296585-yfh5d4io	365	18	-	-	HYPH
cord-296585-yfh5d4io	365	19	κB	κb	CD
cord-296585-yfh5d4io	365	20	subunit	subunit	NN
cord-296585-yfh5d4io	365	21	p65	p65	NN
cord-296585-yfh5d4io	365	22	,	,	,
cord-296585-yfh5d4io	365	23	respectively	respectively	RB
cord-296585-yfh5d4io	365	24	.	.	.
cord-296585-yfh5d4io	366	1	This	this	DT
cord-296585-yfh5d4io	366	2	results	result	VBZ
cord-296585-yfh5d4io	366	3	in	in	IN
cord-296585-yfh5d4io	366	4	enhanced	enhance	VBN
cord-296585-yfh5d4io	366	5	DNA	dna	NN
cord-296585-yfh5d4io	366	6	-	-	HYPH
cord-296585-yfh5d4io	366	7	binding	bind	VBG
cord-296585-yfh5d4io	366	8	activity	activity	NN
cord-296585-yfh5d4io	366	9	of	of	IN
cord-296585-yfh5d4io	366	10	NF	nf	NN
cord-296585-yfh5d4io	366	11	-	-	HYPH
cord-296585-yfh5d4io	366	12	κB	κB	NNP
cord-296585-yfh5d4io	366	13	(	(	-LRB-
cord-296585-yfh5d4io	366	14	254	254	CD
cord-296585-yfh5d4io	366	15	)	)	-RRB-
cord-296585-yfh5d4io	366	16	.	.	.
cord-296585-yfh5d4io	367	1	The	the	DT
cord-296585-yfh5d4io	367	2	synergetic	synergetic	JJ
cord-296585-yfh5d4io	367	3	action	action	NN
cord-296585-yfh5d4io	367	4	of	of	IN
cord-296585-yfh5d4io	367	5	NTHi	NTHi	NNS
cord-296585-yfh5d4io	367	6	with	with	IN
cord-296585-yfh5d4io	367	7	both	both	DT
cord-296585-yfh5d4io	367	8	TNF	TNF	NNP
cord-296585-yfh5d4io	367	9	-	-	HYPH
cord-296585-yfh5d4io	367	10	α	α	NNP
cord-296585-yfh5d4io	367	11	and	and	CC
cord-296585-yfh5d4io	367	12	TGF	TGF	NNP
cord-296585-yfh5d4io	367	13	-	-	HYPH
cord-296585-yfh5d4io	367	14	β1	β1	NNP
cord-296585-yfh5d4io	367	15	enhances	enhance	VBZ
cord-296585-yfh5d4io	367	16	the	the	DT
cord-296585-yfh5d4io	367	17	production	production	NN
cord-296585-yfh5d4io	367	18	of	of	IN
cord-296585-yfh5d4io	367	19	TNF	TNF	NNP
cord-296585-yfh5d4io	367	20	-	-	HYPH
cord-296585-yfh5d4io	367	21	α	α	NNP
cord-296585-yfh5d4io	367	22	,	,	,
cord-296585-yfh5d4io	367	23	IL-1β	IL-1β	NNP
cord-296585-yfh5d4io	367	24	,	,	,
cord-296585-yfh5d4io	367	25	and	and	CC
cord-296585-yfh5d4io	367	26	IL-8	IL-8	NNP
cord-296585-yfh5d4io	367	27	from	from	IN
cord-296585-yfh5d4io	367	28	airway	airway	JJ
cord-296585-yfh5d4io	367	29	epithelial	epithelial	JJ
cord-296585-yfh5d4io	367	30	cells	cell	NNS
cord-296585-yfh5d4io	367	31	and	and	CC
cord-296585-yfh5d4io	367	32	interstitial	interstitial	JJ
cord-296585-yfh5d4io	367	33	polymorphonuclear	polymorphonuclear	NN
cord-296585-yfh5d4io	367	34	infiltrates	infiltrate	VBZ
cord-296585-yfh5d4io	367	35	.	.	.
cord-296585-yfh5d4io	368	1	Recently	recently	RB
cord-296585-yfh5d4io	368	2	,	,	,
cord-296585-yfh5d4io	368	3	it	-PRON-	PRP
cord-296585-yfh5d4io	368	4	has	have	VBZ
cord-296585-yfh5d4io	368	5	been	be	VBN
cord-296585-yfh5d4io	368	6	reported	report	VBN
cord-296585-yfh5d4io	368	7	that	that	IN
cord-296585-yfh5d4io	368	8	co	co	NN
cord-296585-yfh5d4io	368	9	-	-	NN
cord-296585-yfh5d4io	368	10	infection	infection	NN
cord-296585-yfh5d4io	368	11	of	of	IN
cord-296585-yfh5d4io	368	12	human	human	JJ
cord-296585-yfh5d4io	368	13	rhinovirus	rhinovirus	NN
cord-296585-yfh5d4io	368	14	and	and	CC
cord-296585-yfh5d4io	368	15	NTHi	NTHi	NNS
cord-296585-yfh5d4io	368	16	on	on	IN
cord-296585-yfh5d4io	368	17	the	the	DT
cord-296585-yfh5d4io	368	18	airway	airway	NN
cord-296585-yfh5d4io	368	19	epithelial	epithelial	JJ
cord-296585-yfh5d4io	368	20	cells	cell	NNS
cord-296585-yfh5d4io	368	21	(	(	-LRB-
cord-296585-yfh5d4io	368	22	NHBE	nhbe	NN
cord-296585-yfh5d4io	368	23	cells	cell	NNS
cord-296585-yfh5d4io	368	24	and	and	CC
cord-296585-yfh5d4io	368	25	the	the	DT
cord-296585-yfh5d4io	368	26	BEAS-2B	BEAS-2B	NNP
cord-296585-yfh5d4io	368	27	cell	cell	NN
cord-296585-yfh5d4io	368	28	line	line	NN
cord-296585-yfh5d4io	368	29	)	)	-RRB-
cord-296585-yfh5d4io	368	30	also	also	RB
cord-296585-yfh5d4io	368	31	results	result	VBZ
cord-296585-yfh5d4io	368	32	in	in	IN
cord-296585-yfh5d4io	368	33	synergetic	synergetic	JJ
cord-296585-yfh5d4io	368	34	induction	induction	NN
cord-296585-yfh5d4io	368	35	of	of	IN
cord-296585-yfh5d4io	368	36	CCL20	ccl20	NN
cord-296585-yfh5d4io	368	37	and	and	CC
cord-296585-yfh5d4io	368	38	IL-8	IL-8	NNP
cord-296585-yfh5d4io	368	39	,	,	,
cord-296585-yfh5d4io	368	40	albeit	albeit	IN
cord-296585-yfh5d4io	368	41	the	the	DT
cord-296585-yfh5d4io	368	42	exact	exact	JJ
cord-296585-yfh5d4io	368	43	mechanism	mechanism	NN
cord-296585-yfh5d4io	368	44	remains	remain	VBZ
cord-296585-yfh5d4io	368	45	to	to	TO
cord-296585-yfh5d4io	368	46	be	be	VB
cord-296585-yfh5d4io	368	47	elucidated	elucidate	VBN
cord-296585-yfh5d4io	368	48	(	(	-LRB-
cord-296585-yfh5d4io	368	49	255	255	CD
cord-296585-yfh5d4io	368	50	)	)	-RRB-
cord-296585-yfh5d4io	368	51	.	.	.
cord-296585-yfh5d4io	369	1	Of	of	IN
cord-296585-yfh5d4io	369	2	note	note	NN
cord-296585-yfh5d4io	369	3	,	,	,
cord-296585-yfh5d4io	369	4	activated	activate	VBN
cord-296585-yfh5d4io	369	5	macrophages	macrophage	NNS
cord-296585-yfh5d4io	369	6	also	also	RB
cord-296585-yfh5d4io	369	7	release	release	VBP
cord-296585-yfh5d4io	369	8	increased	increase	VBN
cord-296585-yfh5d4io	369	9	concentrations	concentration	NNS
cord-296585-yfh5d4io	369	10	of	of	IN
cord-296585-yfh5d4io	369	11	TNF	TNF	NNP
cord-296585-yfh5d4io	369	12	-	-	HYPH
cord-296585-yfh5d4io	369	13	α	α	NNP
cord-296585-yfh5d4io	369	14	and	and	CC
cord-296585-yfh5d4io	369	15	IL-1α	il-1α	NN
cord-296585-yfh5d4io	369	16	(	(	-LRB-
cord-296585-yfh5d4io	369	17	256	256	CD
cord-296585-yfh5d4io	369	18	)	)	-RRB-
cord-296585-yfh5d4io	369	19	,	,	,
cord-296585-yfh5d4io	369	20	further	further	RB
cord-296585-yfh5d4io	369	21	enhancing	enhance	VBG
cord-296585-yfh5d4io	369	22	the	the	DT
cord-296585-yfh5d4io	369	23	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	369	24	synergetic	synergetic	JJ
cord-296585-yfh5d4io	369	25	effect	effect	NN
cord-296585-yfh5d4io	369	26	of	of	IN
cord-296585-yfh5d4io	369	27	surrounding	surround	VBG
cord-296585-yfh5d4io	369	28	immune	immune	JJ
cord-296585-yfh5d4io	369	29	cells	cell	NNS
cord-296585-yfh5d4io	369	30	.	.	.
cord-296585-yfh5d4io	370	1	Finally	finally	RB
cord-296585-yfh5d4io	370	2	,	,	,
cord-296585-yfh5d4io	370	3	IL-1α	IL-1α	NNP
cord-296585-yfh5d4io	370	4	acts	act	VBZ
cord-296585-yfh5d4io	370	5	synergetically	synergetically	RB
cord-296585-yfh5d4io	370	6	with	with	IN
cord-296585-yfh5d4io	370	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	370	8	to	to	TO
cord-296585-yfh5d4io	370	9	upregulate	upregulate	VB
cord-296585-yfh5d4io	370	10	the	the	DT
cord-296585-yfh5d4io	370	11	expression	expression	NN
cord-296585-yfh5d4io	370	12	of	of	IN
cord-296585-yfh5d4io	370	13	AMP	AMP	NNP
cord-296585-yfh5d4io	370	14	β	β	NNP
cord-296585-yfh5d4io	370	15	-	-	HYPH
cord-296585-yfh5d4io	370	16	defensin	defensin	NNP
cord-296585-yfh5d4io	370	17	2	2	CD
cord-296585-yfh5d4io	370	18	(	(	-LRB-
cord-296585-yfh5d4io	370	19	DEFB-4	DEFB-4	NNP
cord-296585-yfh5d4io	370	20	)	)	-RRB-
cord-296585-yfh5d4io	370	21	via	via	IN
cord-296585-yfh5d4io	370	22	the	the	DT
cord-296585-yfh5d4io	370	23	p38	p38	CD
cord-296585-yfh5d4io	370	24	/	/	SYM
cord-296585-yfh5d4io	370	25	MAPK	MAPK	NNP
cord-296585-yfh5d4io	370	26	pathway	pathway	NN
cord-296585-yfh5d4io	370	27	(	(	-LRB-
cord-296585-yfh5d4io	370	28	257	257	CD
cord-296585-yfh5d4io	370	29	)	)	-RRB-
cord-296585-yfh5d4io	370	30	.	.	.
cord-296585-yfh5d4io	371	1	Of	of	IN
cord-296585-yfh5d4io	371	2	note	note	NN
cord-296585-yfh5d4io	371	3	,	,	,
cord-296585-yfh5d4io	371	4	IL-1α	IL-1α	NNP
cord-296585-yfh5d4io	371	5	could	could	MD
cord-296585-yfh5d4io	371	6	also	also	RB
cord-296585-yfh5d4io	371	7	act	act	VB
cord-296585-yfh5d4io	371	8	individually	individually	RB
cord-296585-yfh5d4io	371	9	to	to	TO
cord-296585-yfh5d4io	371	10	upregulate	upregulate	VB
cord-296585-yfh5d4io	371	11	the	the	DT
cord-296585-yfh5d4io	371	12	expression	expression	NN
cord-296585-yfh5d4io	371	13	of	of	IN
cord-296585-yfh5d4io	371	14	DEFB-4	DEFB-4	NNP
cord-296585-yfh5d4io	371	15	via	via	IN
cord-296585-yfh5d4io	371	16	the	the	DT
cord-296585-yfh5d4io	371	17	Src	Src	NNP
cord-296585-yfh5d4io	371	18	-	-	HYPH
cord-296585-yfh5d4io	371	19	dependent	dependent	JJ
cord-296585-yfh5d4io	371	20	MEK1/2-ERK1/2	mek1/2-erk1/2	NN
cord-296585-yfh5d4io	371	21	signaling	signal	VBG
cord-296585-yfh5d4io	371	22	pathway	pathway	NN
cord-296585-yfh5d4io	371	23	(	(	-LRB-
cord-296585-yfh5d4io	371	24	258	258	CD
cord-296585-yfh5d4io	371	25	)	)	-RRB-
cord-296585-yfh5d4io	371	26	.	.	.
cord-296585-yfh5d4io	372	1	Taken	take	VBN
cord-296585-yfh5d4io	372	2	together	together	RB
cord-296585-yfh5d4io	372	3	,	,	,
cord-296585-yfh5d4io	372	4	the	the	DT
cord-296585-yfh5d4io	372	5	synergetic	synergetic	JJ
cord-296585-yfh5d4io	372	6	action	action	NN
cord-296585-yfh5d4io	372	7	may	may	MD
cord-296585-yfh5d4io	372	8	aid	aid	VB
cord-296585-yfh5d4io	372	9	in	in	IN
cord-296585-yfh5d4io	372	10	the	the	DT
cord-296585-yfh5d4io	372	11	expansion	expansion	NN
cord-296585-yfh5d4io	372	12	of	of	IN
cord-296585-yfh5d4io	372	13	the	the	DT
cord-296585-yfh5d4io	372	14	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	372	15	response	response	NN
cord-296585-yfh5d4io	372	16	and	and	CC
cord-296585-yfh5d4io	372	17	in	in	IN
cord-296585-yfh5d4io	372	18	some	some	DT
cord-296585-yfh5d4io	372	19	cases	case	NNS
cord-296585-yfh5d4io	372	20	worsen	worsen	VBP
cord-296585-yfh5d4io	372	21	the	the	DT
cord-296585-yfh5d4io	372	22	clinical	clinical	JJ
cord-296585-yfh5d4io	372	23	outcome	outcome	NN
cord-296585-yfh5d4io	372	24	.	.	.
cord-296585-yfh5d4io	373	1	Alveolar	alveolar	NN
cord-296585-yfh5d4io	373	2	macrophages	macrophage	NNS
cord-296585-yfh5d4io	373	3	located	locate	VBN
cord-296585-yfh5d4io	373	4	in	in	IN
cord-296585-yfh5d4io	373	5	the	the	DT
cord-296585-yfh5d4io	373	6	air	air	NN
cord-296585-yfh5d4io	373	7	-	-	HYPH
cord-296585-yfh5d4io	373	8	parenchyma	parenchyma	NN
cord-296585-yfh5d4io	373	9	interface	interface	NN
cord-296585-yfh5d4io	373	10	are	be	VBP
cord-296585-yfh5d4io	373	11	the	the	DT
cord-296585-yfh5d4io	373	12	primary	primary	JJ
cord-296585-yfh5d4io	373	13	professional	professional	JJ
cord-296585-yfh5d4io	373	14	phagocytes	phagocyte	NNS
cord-296585-yfh5d4io	373	15	in	in	IN
cord-296585-yfh5d4io	373	16	the	the	DT
cord-296585-yfh5d4io	373	17	lung	lung	NN
cord-296585-yfh5d4io	373	18	(	(	-LRB-
cord-296585-yfh5d4io	373	19	259	259	CD
cord-296585-yfh5d4io	373	20	,	,	,
cord-296585-yfh5d4io	373	21	260	260	CD
cord-296585-yfh5d4io	373	22	)	)	-RRB-
cord-296585-yfh5d4io	373	23	.	.	.
cord-296585-yfh5d4io	374	1	These	these	DT
cord-296585-yfh5d4io	374	2	cells	cell	NNS
cord-296585-yfh5d4io	374	3	are	be	VBP
cord-296585-yfh5d4io	374	4	responsible	responsible	JJ
cord-296585-yfh5d4io	374	5	for	for	IN
cord-296585-yfh5d4io	374	6	infection	infection	NN
cord-296585-yfh5d4io	374	7	eradication	eradication	NN
cord-296585-yfh5d4io	374	8	through	through	IN
cord-296585-yfh5d4io	374	9	its	-PRON-	PRP$
cord-296585-yfh5d4io	374	10	phagolysosomal	phagolysosomal	JJ
cord-296585-yfh5d4io	374	11	machinery	machinery	NN
cord-296585-yfh5d4io	374	12	while	while	IN
cord-296585-yfh5d4io	374	13	releasing	release	VBG
cord-296585-yfh5d4io	374	14	a	a	DT
cord-296585-yfh5d4io	374	15	plethora	plethora	NN
cord-296585-yfh5d4io	374	16	of	of	IN
cord-296585-yfh5d4io	374	17	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	374	18	cytokines	cytokine	NNS
cord-296585-yfh5d4io	374	19	and	and	CC
cord-296585-yfh5d4io	374	20	chemokines	chemokine	NNS
cord-296585-yfh5d4io	374	21	for	for	IN
cord-296585-yfh5d4io	374	22	promoting	promote	VBG
cord-296585-yfh5d4io	374	23	a	a	DT
cord-296585-yfh5d4io	374	24	local	local	JJ
cord-296585-yfh5d4io	374	25	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	374	26	response	response	NN
cord-296585-yfh5d4io	374	27	and	and	CC
cord-296585-yfh5d4io	374	28	recruitment	recruitment	NN
cord-296585-yfh5d4io	374	29	of	of	IN
cord-296585-yfh5d4io	374	30	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	374	31	.	.	.
cord-296585-yfh5d4io	375	1	Neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	375	2	are	be	VBP
cord-296585-yfh5d4io	375	3	the	the	DT
cord-296585-yfh5d4io	375	4	first	first	JJ
cord-296585-yfh5d4io	375	5	responder	responder	NN
cord-296585-yfh5d4io	375	6	cells	cell	NNS
cord-296585-yfh5d4io	375	7	recruited	recruit	VBN
cord-296585-yfh5d4io	375	8	from	from	IN
cord-296585-yfh5d4io	375	9	circulation	circulation	NN
cord-296585-yfh5d4io	375	10	to	to	IN
cord-296585-yfh5d4io	375	11	the	the	DT
cord-296585-yfh5d4io	375	12	airway	airway	NN
cord-296585-yfh5d4io	375	13	for	for	IN
cord-296585-yfh5d4io	375	14	efficient	efficient	JJ
cord-296585-yfh5d4io	375	15	killing	killing	NN
cord-296585-yfh5d4io	375	16	of	of	IN
cord-296585-yfh5d4io	375	17	pathogens	pathogen	NNS
cord-296585-yfh5d4io	375	18	through	through	IN
cord-296585-yfh5d4io	375	19	an	an	DT
cord-296585-yfh5d4io	375	20	array	array	NN
cord-296585-yfh5d4io	375	21	of	of	IN
cord-296585-yfh5d4io	375	22	microbicidal	microbicidal	JJ
cord-296585-yfh5d4io	375	23	strategies	strategy	NNS
cord-296585-yfh5d4io	375	24	(	(	-LRB-
cord-296585-yfh5d4io	375	25	261	261	CD
cord-296585-yfh5d4io	375	26	,	,	,
cord-296585-yfh5d4io	375	27	262	262	CD
cord-296585-yfh5d4io	375	28	)	)	-RRB-
cord-296585-yfh5d4io	375	29	.	.	.
cord-296585-yfh5d4io	376	1	During	during	IN
cord-296585-yfh5d4io	376	2	NTHi	NTHi	NNS
cord-296585-yfh5d4io	376	3	lung	lung	NN
cord-296585-yfh5d4io	376	4	infection	infection	NN
cord-296585-yfh5d4io	376	5	,	,	,
cord-296585-yfh5d4io	376	6	both	both	DT
cord-296585-yfh5d4io	376	7	alveolar	alveolar	JJ
cord-296585-yfh5d4io	376	8	macrophages	macrophage	NNS
cord-296585-yfh5d4io	376	9	and	and	CC
cord-296585-yfh5d4io	376	10	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	376	11	are	be	VBP
cord-296585-yfh5d4io	376	12	the	the	DT
cord-296585-yfh5d4io	376	13	main	main	JJ
cord-296585-yfh5d4io	376	14	innate	innate	JJ
cord-296585-yfh5d4io	376	15	immune	immune	JJ
cord-296585-yfh5d4io	376	16	cells	cell	NNS
cord-296585-yfh5d4io	376	17	involved	involve	VBN
cord-296585-yfh5d4io	376	18	in	in	IN
cord-296585-yfh5d4io	376	19	the	the	DT
cord-296585-yfh5d4io	376	20	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	376	21	bacterial	bacterial	JJ
cord-296585-yfh5d4io	376	22	clearance	clearance	NN
cord-296585-yfh5d4io	376	23	through	through	IN
cord-296585-yfh5d4io	376	24	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	376	25	.	.	.
cord-296585-yfh5d4io	377	1	They	-PRON-	PRP
cord-296585-yfh5d4io	377	2	are	be	VBP
cord-296585-yfh5d4io	377	3	also	also	RB
cord-296585-yfh5d4io	377	4	an	an	DT
cord-296585-yfh5d4io	377	5	important	important	JJ
cord-296585-yfh5d4io	377	6	source	source	NN
cord-296585-yfh5d4io	377	7	of	of	IN
cord-296585-yfh5d4io	377	8	cytokine	cytokine	JJ
cord-296585-yfh5d4io	377	9	secretion	secretion	NN
cord-296585-yfh5d4io	377	10	required	require	VBN
cord-296585-yfh5d4io	377	11	for	for	IN
cord-296585-yfh5d4io	377	12	induction	induction	NN
cord-296585-yfh5d4io	377	13	of	of	IN
cord-296585-yfh5d4io	377	14	other	other	JJ
cord-296585-yfh5d4io	377	15	immune	immune	JJ
cord-296585-yfh5d4io	377	16	cells	cell	NNS
cord-296585-yfh5d4io	377	17	and	and	CC
cord-296585-yfh5d4io	377	18	enhanced	enhance	VBN
cord-296585-yfh5d4io	377	19	bacterial	bacterial	JJ
cord-296585-yfh5d4io	377	20	killing	killing	NN
cord-296585-yfh5d4io	377	21	.	.	.
cord-296585-yfh5d4io	378	1	Eradication	eradication	NN
cord-296585-yfh5d4io	378	2	of	of	IN
cord-296585-yfh5d4io	378	3	NTHi	NTHi	NNS
cord-296585-yfh5d4io	378	4	by	by	IN
cord-296585-yfh5d4io	378	5	alveolar	alveolar	JJ
cord-296585-yfh5d4io	378	6	macrophages	macrophage	NNS
cord-296585-yfh5d4io	378	7	involves	involve	VBZ
cord-296585-yfh5d4io	378	8	adhesion	adhesion	NN
cord-296585-yfh5d4io	378	9	or	or	CC
cord-296585-yfh5d4io	378	10	contact	contact	NN
cord-296585-yfh5d4io	378	11	,	,	,
cord-296585-yfh5d4io	378	12	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	378	13	and	and	CC
cord-296585-yfh5d4io	378	14	phagolysosomal	phagolysosomal	JJ
cord-296585-yfh5d4io	378	15	processing	processing	NN
cord-296585-yfh5d4io	378	16	of	of	IN
cord-296585-yfh5d4io	378	17	bacteria	bacteria	NNS
cord-296585-yfh5d4io	378	18	,	,	,
cord-296585-yfh5d4io	378	19	in	in	IN
cord-296585-yfh5d4io	378	20	addition	addition	NN
cord-296585-yfh5d4io	378	21	to	to	IN
cord-296585-yfh5d4io	378	22	secretion	secretion	NN
cord-296585-yfh5d4io	378	23	of	of	IN
cord-296585-yfh5d4io	378	24	TNF	TNF	NNP
cord-296585-yfh5d4io	378	25	-	-	HYPH
cord-296585-yfh5d4io	378	26	α	α	NNP
cord-296585-yfh5d4io	378	27	.	.	.
cord-296585-yfh5d4io	379	1	Phagocytic	phagocytic	JJ
cord-296585-yfh5d4io	379	2	clearance	clearance	NN
cord-296585-yfh5d4io	379	3	of	of	IN
cord-296585-yfh5d4io	379	4	NTHi	NTHi	NNS
cord-296585-yfh5d4io	379	5	by	by	IN
cord-296585-yfh5d4io	379	6	alveolar	alveolar	JJ
cord-296585-yfh5d4io	379	7	macrophages	macrophage	NNS
cord-296585-yfh5d4io	379	8	is	be	VBZ
cord-296585-yfh5d4io	379	9	orchestrated	orchestrate	VBN
cord-296585-yfh5d4io	379	10	through	through	IN
cord-296585-yfh5d4io	379	11	actin	actin	NN
cord-296585-yfh5d4io	379	12	polymerization	polymerization	NN
cord-296585-yfh5d4io	379	13	,	,	,
cord-296585-yfh5d4io	379	14	plasma	plasma	NN
cord-296585-yfh5d4io	379	15	membrane	membrane	NN
cord-296585-yfh5d4io	379	16	lipid	lipid	NN
cord-296585-yfh5d4io	379	17	rafts	raft	NNS
cord-296585-yfh5d4io	379	18	,	,	,
cord-296585-yfh5d4io	379	19	and	and	CC
cord-296585-yfh5d4io	380	1	phosphatidylinositol	phosphatidylinositol	JJ
cord-296585-yfh5d4io	380	2	3-kinase	3-kinase	CD
cord-296585-yfh5d4io	380	3	(	(	-LRB-
cord-296585-yfh5d4io	380	4	PI3	PI3	NNP
cord-296585-yfh5d4io	380	5	K	K	NNP
cord-296585-yfh5d4io	380	6	)	)	-RRB-
cord-296585-yfh5d4io	380	7	signaling	signal	VBG
cord-296585-yfh5d4io	380	8	cascade	cascade	NN
cord-296585-yfh5d4io	380	9	upon	upon	IN
cord-296585-yfh5d4io	380	10	induction	induction	NN
cord-296585-yfh5d4io	380	11	of	of	IN
cord-296585-yfh5d4io	380	12	macrophage	macrophage	NN
cord-296585-yfh5d4io	380	13	PRRs	prr	NNS
cord-296585-yfh5d4io	380	14	by	by	IN
cord-296585-yfh5d4io	380	15	NTHi	NTHi	NNS
cord-296585-yfh5d4io	380	16	(	(	-LRB-
cord-296585-yfh5d4io	380	17	256	256	CD
cord-296585-yfh5d4io	380	18	)	)	-RRB-
cord-296585-yfh5d4io	380	19	.	.	.
cord-296585-yfh5d4io	381	1	Interestingly	interestingly	RB
cord-296585-yfh5d4io	381	2	,	,	,
cord-296585-yfh5d4io	381	3	in	in	IN
cord-296585-yfh5d4io	381	4	response	response	NN
cord-296585-yfh5d4io	381	5	to	to	IN
cord-296585-yfh5d4io	381	6	NTHi	NTHi	NNS
cord-296585-yfh5d4io	381	7	infection	infection	NN
cord-296585-yfh5d4io	381	8	,	,	,
cord-296585-yfh5d4io	381	9	human	human	JJ
cord-296585-yfh5d4io	381	10	alveolar	alveolar	NN
cord-296585-yfh5d4io	381	11	macrophages	macrophage	NNS
cord-296585-yfh5d4io	381	12	,	,	,
cord-296585-yfh5d4io	381	13	and	and	CC
cord-296585-yfh5d4io	381	14	blood	blood	NN
cord-296585-yfh5d4io	381	15	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	381	16	produce	produce	VBP
cord-296585-yfh5d4io	381	17	extensive	extensive	JJ
cord-296585-yfh5d4io	381	18	amount	amount	NN
cord-296585-yfh5d4io	381	19	of	of	IN
cord-296585-yfh5d4io	381	20	intracellular	intracellular	JJ
cord-296585-yfh5d4io	381	21	and	and	CC
cord-296585-yfh5d4io	381	22	extracellular	extracellular	JJ
cord-296585-yfh5d4io	381	23	ROS	ROS	NNP
cord-296585-yfh5d4io	381	24	as	as	IN
cord-296585-yfh5d4io	381	25	a	a	DT
cord-296585-yfh5d4io	381	26	component	component	NN
cord-296585-yfh5d4io	381	27	of	of	IN
cord-296585-yfh5d4io	381	28	the	the	DT
cord-296585-yfh5d4io	381	29	antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	381	30	defense	defense	NN
cord-296585-yfh5d4io	381	31	.	.	.
cord-296585-yfh5d4io	382	1	This	this	DT
cord-296585-yfh5d4io	382	2	leads	lead	VBZ
cord-296585-yfh5d4io	382	3	to	to	IN
cord-296585-yfh5d4io	382	4	the	the	DT
cord-296585-yfh5d4io	382	5	formation	formation	NN
cord-296585-yfh5d4io	382	6	of	of	IN
cord-296585-yfh5d4io	382	7	macrophage	macrophage	NN
cord-296585-yfh5d4io	382	8	and	and	CC
cord-296585-yfh5d4io	382	9	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	382	10	extracellular	extracellular	JJ
cord-296585-yfh5d4io	382	11	traps	trap	NNS
cord-296585-yfh5d4io	382	12	(	(	-LRB-
cord-296585-yfh5d4io	382	13	METs	METs	NNPS
cord-296585-yfh5d4io	382	14	and	and	CC
cord-296585-yfh5d4io	382	15	NETs	net	NNS
cord-296585-yfh5d4io	382	16	,	,	,
cord-296585-yfh5d4io	382	17	respectively	respectively	RB
cord-296585-yfh5d4io	382	18	)	)	-RRB-
cord-296585-yfh5d4io	382	19	,	,	,
cord-296585-yfh5d4io	382	20	with	with	IN
cord-296585-yfh5d4io	382	21	co	co	NN
cord-296585-yfh5d4io	382	22	-	-	NN
cord-296585-yfh5d4io	382	23	expression	expression	NN
cord-296585-yfh5d4io	382	24	of	of	IN
cord-296585-yfh5d4io	382	25	MMP-12	MMP-12	NNP
cord-296585-yfh5d4io	382	26	for	for	IN
cord-296585-yfh5d4io	382	27	enhanced	enhanced	JJ
cord-296585-yfh5d4io	382	28	bacterial	bacterial	JJ
cord-296585-yfh5d4io	382	29	killing	killing	NN
cord-296585-yfh5d4io	382	30	(	(	-LRB-
cord-296585-yfh5d4io	382	31	263	263	CD
cord-296585-yfh5d4io	382	32	,	,	,
cord-296585-yfh5d4io	382	33	264	264	CD
cord-296585-yfh5d4io	382	34	)	)	-RRB-
cord-296585-yfh5d4io	382	35	.	.	.
cord-296585-yfh5d4io	383	1	Nevertheless	nevertheless	RB
cord-296585-yfh5d4io	383	2	,	,	,
cord-296585-yfh5d4io	383	3	the	the	DT
cord-296585-yfh5d4io	383	4	overexpression	overexpression	NN
cord-296585-yfh5d4io	383	5	of	of	IN
cord-296585-yfh5d4io	383	6	MMPs	mmp	NNS
cord-296585-yfh5d4io	383	7	may	may	MD
cord-296585-yfh5d4io	383	8	adversely	adversely	RB
cord-296585-yfh5d4io	383	9	result	result	VB
cord-296585-yfh5d4io	383	10	in	in	IN
cord-296585-yfh5d4io	383	11	a	a	DT
cord-296585-yfh5d4io	383	12	protease	protease	NN
cord-296585-yfh5d4io	383	13	imbalance	imbalance	NN
cord-296585-yfh5d4io	383	14	and	and	CC
cord-296585-yfh5d4io	383	15	contribute	contribute	VB
cord-296585-yfh5d4io	383	16	to	to	IN
cord-296585-yfh5d4io	383	17	alveolar	alveolar	JJ
cord-296585-yfh5d4io	383	18	emphysematous	emphysematous	JJ
cord-296585-yfh5d4io	383	19	destruction	destruction	NN
cord-296585-yfh5d4io	383	20	and	and	CC
cord-296585-yfh5d4io	383	21	bronchiectasis	bronchiectasis	NN
cord-296585-yfh5d4io	383	22	in	in	IN
cord-296585-yfh5d4io	383	23	COPD	COPD	NNP
cord-296585-yfh5d4io	383	24	(	(	-LRB-
cord-296585-yfh5d4io	383	25	265	265	CD
cord-296585-yfh5d4io	383	26	)	)	-RRB-
cord-296585-yfh5d4io	383	27	.	.	.
cord-296585-yfh5d4io	384	1	Moreover	moreover	RB
cord-296585-yfh5d4io	384	2	,	,	,
cord-296585-yfh5d4io	384	3	excessive	excessive	JJ
cord-296585-yfh5d4io	384	4	endogenous	endogenous	JJ
cord-296585-yfh5d4io	384	5	ROS	ROS	NNP
cord-296585-yfh5d4io	384	6	production	production	NN
cord-296585-yfh5d4io	384	7	could	could	MD
cord-296585-yfh5d4io	384	8	also	also	RB
cord-296585-yfh5d4io	384	9	introduce	introduce	VB
cord-296585-yfh5d4io	384	10	airway	airway	NN
cord-296585-yfh5d4io	384	11	oxidative	oxidative	JJ
cord-296585-yfh5d4io	384	12	stress	stress	NN
cord-296585-yfh5d4io	384	13	that	that	WDT
cord-296585-yfh5d4io	384	14	is	be	VBZ
cord-296585-yfh5d4io	384	15	detrimental	detrimental	JJ
cord-296585-yfh5d4io	384	16	by	by	IN
cord-296585-yfh5d4io	384	17	causing	cause	VBG
cord-296585-yfh5d4io	384	18	chronic	chronic	JJ
cord-296585-yfh5d4io	384	19	inflammation	inflammation	NN
cord-296585-yfh5d4io	384	20	and	and	CC
cord-296585-yfh5d4io	384	21	tissue	tissue	NN
cord-296585-yfh5d4io	384	22	damage	damage	NN
cord-296585-yfh5d4io	384	23	in	in	IN
cord-296585-yfh5d4io	384	24	the	the	DT
cord-296585-yfh5d4io	384	25	lung	lung	NN
cord-296585-yfh5d4io	384	26	,	,	,
cord-296585-yfh5d4io	384	27	and	and	CC
cord-296585-yfh5d4io	384	28	thus	thus	RB
cord-296585-yfh5d4io	384	29	contributing	contribute	VBG
cord-296585-yfh5d4io	384	30	to	to	IN
cord-296585-yfh5d4io	384	31	the	the	DT
cord-296585-yfh5d4io	384	32	COPD	COPD	NNP
cord-296585-yfh5d4io	384	33	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	384	34	(	(	-LRB-
cord-296585-yfh5d4io	384	35	266	266	CD
cord-296585-yfh5d4io	384	36	,	,	,
cord-296585-yfh5d4io	384	37	267	267	CD
cord-296585-yfh5d4io	384	38	)	)	-RRB-
cord-296585-yfh5d4io	384	39	.	.	.
cord-296585-yfh5d4io	385	1	The	the	DT
cord-296585-yfh5d4io	385	2	NET	net	JJ
cord-296585-yfh5d4io	385	3	formation	formation	NN
cord-296585-yfh5d4io	385	4	is	be	VBZ
cord-296585-yfh5d4io	385	5	elicited	elicit	VBN
cord-296585-yfh5d4io	385	6	mainly	mainly	RB
cord-296585-yfh5d4io	385	7	by	by	IN
cord-296585-yfh5d4io	385	8	NTHi	NTHi	NNS
cord-296585-yfh5d4io	385	9	LOS	LOS	NNP
cord-296585-yfh5d4io	385	10	in	in	IN
cord-296585-yfh5d4io	385	11	addition	addition	NN
cord-296585-yfh5d4io	385	12	to	to	IN
cord-296585-yfh5d4io	385	13	other	other	JJ
cord-296585-yfh5d4io	385	14	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	385	15	PAMPs	pamp	NNS
cord-296585-yfh5d4io	385	16	(	(	-LRB-
cord-296585-yfh5d4io	385	17	264	264	CD
cord-296585-yfh5d4io	385	18	)	)	-RRB-
cord-296585-yfh5d4io	385	19	.	.	.
cord-296585-yfh5d4io	386	1	Several	several	JJ
cord-296585-yfh5d4io	386	2	studies	study	NNS
cord-296585-yfh5d4io	386	3	by	by	IN
cord-296585-yfh5d4io	386	4	King	King	NNP
cord-296585-yfh5d4io	386	5	et	et	NNP
cord-296585-yfh5d4io	386	6	al	al	NNP
cord-296585-yfh5d4io	386	7	.	.	NNP
cord-296585-yfh5d4io	386	8	have	have	VBP
cord-296585-yfh5d4io	386	9	revealed	reveal	VBN
cord-296585-yfh5d4io	386	10	that	that	IN
cord-296585-yfh5d4io	386	11	T	T	NNP
cord-296585-yfh5d4io	386	12	cellmediated	cellmediate	VBN
cord-296585-yfh5d4io	386	13	adaptive	adaptive	JJ
cord-296585-yfh5d4io	386	14	immune	immune	JJ
cord-296585-yfh5d4io	386	15	responses	response	NNS
cord-296585-yfh5d4io	386	16	against	against	IN
cord-296585-yfh5d4io	386	17	NTHi	nthi	JJ
cord-296585-yfh5d4io	386	18	airway	airway	NN
cord-296585-yfh5d4io	386	19	infection	infection	NN
cord-296585-yfh5d4io	386	20	in	in	IN
cord-296585-yfh5d4io	386	21	patients	patient	NNS
cord-296585-yfh5d4io	386	22	with	with	IN
cord-296585-yfh5d4io	386	23	idiopathic	idiopathic	JJ
cord-296585-yfh5d4io	386	24	bronchiectasis	bronchiectasis	NN
cord-296585-yfh5d4io	386	25	and	and	CC
cord-296585-yfh5d4io	386	26	COPD	COPD	NNP
cord-296585-yfh5d4io	386	27	has	have	VBZ
cord-296585-yfh5d4io	386	28	been	be	VBN
cord-296585-yfh5d4io	386	29	predominated	predominate	VBN
cord-296585-yfh5d4io	386	30	by	by	IN
cord-296585-yfh5d4io	386	31	a	a	DT
cord-296585-yfh5d4io	386	32	Th2	th2	CD
cord-296585-yfh5d4io	386	33	/	/	SYM
cord-296585-yfh5d4io	386	34	Tc2	tc2	NN
cord-296585-yfh5d4io	386	35	response	response	NN
cord-296585-yfh5d4io	386	36	(	(	-LRB-
cord-296585-yfh5d4io	386	37	268	268	CD
cord-296585-yfh5d4io	386	38	)	)	-RRB-
cord-296585-yfh5d4io	386	39	(	(	-LRB-
cord-296585-yfh5d4io	386	40	269	269	CD
cord-296585-yfh5d4io	386	41	)	)	-RRB-
cord-296585-yfh5d4io	386	42	(	(	-LRB-
cord-296585-yfh5d4io	386	43	270	270	CD
cord-296585-yfh5d4io	386	44	)	)	-RRB-
cord-296585-yfh5d4io	386	45	.	.	.
cord-296585-yfh5d4io	387	1	The	the	DT
cord-296585-yfh5d4io	387	2	activated	activate	VBN
cord-296585-yfh5d4io	387	3	T	t	NN
cord-296585-yfh5d4io	387	4	cells	cell	NNS
cord-296585-yfh5d4io	387	5	produce	produce	VBP
cord-296585-yfh5d4io	387	6	reduced	reduce	VBN
cord-296585-yfh5d4io	387	7	level	level	NN
cord-296585-yfh5d4io	387	8	of	of	IN
cord-296585-yfh5d4io	387	9	the	the	DT
cord-296585-yfh5d4io	387	10	CD40	CD40	NNP
cord-296585-yfh5d4io	387	11	ligand	ligand	NN
cord-296585-yfh5d4io	387	12	and	and	CC
cord-296585-yfh5d4io	387	13	IFN	IFN	NNP
cord-296585-yfh5d4io	387	14	-	-	HYPH
cord-296585-yfh5d4io	387	15	γ	γ	NNP
cord-296585-yfh5d4io	387	16	,	,	,
cord-296585-yfh5d4io	387	17	and	and	CC
cord-296585-yfh5d4io	387	18	increased	increase	VBN
cord-296585-yfh5d4io	387	19	levels	level	NNS
cord-296585-yfh5d4io	387	20	of	of	IN
cord-296585-yfh5d4io	387	21	TNF	TNF	NNP
cord-296585-yfh5d4io	387	22	-	-	HYPH
cord-296585-yfh5d4io	387	23	α	α	NNP
cord-296585-yfh5d4io	387	24	,	,	,
cord-296585-yfh5d4io	387	25	IL-13	IL-13	NNP
cord-296585-yfh5d4io	387	26	,	,	,
cord-296585-yfh5d4io	387	27	and	and	CC
cord-296585-yfh5d4io	387	28	IL-17	IL-17	NNP
cord-296585-yfh5d4io	387	29	,	,	,
cord-296585-yfh5d4io	387	30	as	as	RB
cord-296585-yfh5d4io	387	31	well	well	RB
cord-296585-yfh5d4io	387	32	as	as	IN
cord-296585-yfh5d4io	387	33	altered	alter	VBN
cord-296585-yfh5d4io	387	34	IgG	igg	NN
cord-296585-yfh5d4io	387	35	subclass	subclass	NN
cord-296585-yfh5d4io	387	36	production	production	NN
cord-296585-yfh5d4io	387	37	by	by	IN
cord-296585-yfh5d4io	387	38	plasma	plasma	NN
cord-296585-yfh5d4io	387	39	cells	cell	NNS
cord-296585-yfh5d4io	387	40	.	.	.
cord-296585-yfh5d4io	388	1	It	-PRON-	PRP
cord-296585-yfh5d4io	388	2	is	be	VBZ
cord-296585-yfh5d4io	388	3	to	to	TO
cord-296585-yfh5d4io	388	4	be	be	VB
cord-296585-yfh5d4io	388	5	noted	note	VBN
cord-296585-yfh5d4io	388	6	that	that	IN
cord-296585-yfh5d4io	388	7	the	the	DT
cord-296585-yfh5d4io	388	8	Th2	Th2	NNP
cord-296585-yfh5d4io	388	9	/	/	SYM
cord-296585-yfh5d4io	388	10	Tc2-mediated	Tc2-mediated	NNP
cord-296585-yfh5d4io	388	11	immune	immune	JJ
cord-296585-yfh5d4io	388	12	response	response	NN
cord-296585-yfh5d4io	388	13	is	be	VBZ
cord-296585-yfh5d4io	388	14	less	less	RBR
cord-296585-yfh5d4io	388	15	effective	effective	JJ
cord-296585-yfh5d4io	388	16	in	in	IN
cord-296585-yfh5d4io	388	17	suppressing	suppress	VBG
cord-296585-yfh5d4io	388	18	NTHi	NTHi	NNS
cord-296585-yfh5d4io	388	19	infection	infection	NN
cord-296585-yfh5d4io	388	20	.	.	.
cord-296585-yfh5d4io	389	1	Redirecting	redirect	VBG
cord-296585-yfh5d4io	389	2	the	the	DT
cord-296585-yfh5d4io	389	3	Th2	th2	CD
cord-296585-yfh5d4io	389	4	/	/	SYM
cord-296585-yfh5d4io	389	5	Tc2-mediated	Tc2-mediated	NNP
cord-296585-yfh5d4io	389	6	immune	immune	JJ
cord-296585-yfh5d4io	389	7	response	response	NN
cord-296585-yfh5d4io	389	8	to	to	IN
cord-296585-yfh5d4io	389	9	Th1	th1	CD
cord-296585-yfh5d4io	389	10	/	/	SYM
cord-296585-yfh5d4io	389	11	Tc1	tc1	CD
cord-296585-yfh5d4io	389	12	dominant	dominant	NN
cord-296585-yfh5d4io	389	13	(	(	-LRB-
cord-296585-yfh5d4io	389	14	which	which	WDT
cord-296585-yfh5d4io	389	15	is	be	VBZ
cord-296585-yfh5d4io	389	16	more	more	RBR
cord-296585-yfh5d4io	389	17	protective	protective	JJ
cord-296585-yfh5d4io	389	18	)	)	-RRB-
cord-296585-yfh5d4io	389	19	by	by	IN
cord-296585-yfh5d4io	389	20	adding	add	VBG
cord-296585-yfh5d4io	389	21	the	the	DT
cord-296585-yfh5d4io	389	22	Th1	th1	CD
cord-296585-yfh5d4io	389	23	/	/	SYM
cord-296585-yfh5d4io	389	24	Tc1	tc1	CD
cord-296585-yfh5d4io	389	25	mediators	mediator	NNS
cord-296585-yfh5d4io	389	26	(	(	-LRB-
cord-296585-yfh5d4io	389	27	CD40	CD40	NNP
cord-296585-yfh5d4io	389	28	ligand	ligand	NN
cord-296585-yfh5d4io	389	29	and	and	CC
cord-296585-yfh5d4io	389	30	IFN	IFN	NNP
cord-296585-yfh5d4io	389	31	-	-	HYPH
cord-296585-yfh5d4io	389	32	γ	γ	NNP
cord-296585-yfh5d4io	389	33	)	)	-RRB-
cord-296585-yfh5d4io	389	34	has	have	VBZ
cord-296585-yfh5d4io	389	35	helped	help	VBN
cord-296585-yfh5d4io	389	36	to	to	TO
cord-296585-yfh5d4io	389	37	restore	restore	VB
cord-296585-yfh5d4io	389	38	the	the	DT
cord-296585-yfh5d4io	389	39	T	T	NNP
cord-296585-yfh5d4io	389	40	cellmediated	cellmediate	VBN
cord-296585-yfh5d4io	389	41	immune	immune	JJ
cord-296585-yfh5d4io	389	42	killing	killing	NN
cord-296585-yfh5d4io	389	43	of	of	IN
cord-296585-yfh5d4io	389	44	NTHi	NTHi	NNS
cord-296585-yfh5d4io	389	45	(	(	-LRB-
cord-296585-yfh5d4io	389	46	269	269	CD
cord-296585-yfh5d4io	389	47	)	)	-RRB-
cord-296585-yfh5d4io	389	48	.	.	.
cord-296585-yfh5d4io	390	1	However	however	RB
cord-296585-yfh5d4io	390	2	,	,	,
cord-296585-yfh5d4io	390	3	a	a	DT
cord-296585-yfh5d4io	390	4	separate	separate	JJ
cord-296585-yfh5d4io	390	5	study	study	NN
cord-296585-yfh5d4io	390	6	in	in	IN
cord-296585-yfh5d4io	390	7	a	a	DT
cord-296585-yfh5d4io	390	8	COPD	COPD	NNP
cord-296585-yfh5d4io	390	9	mouse	mouse	NN
cord-296585-yfh5d4io	390	10	model	model	NN
cord-296585-yfh5d4io	390	11	by	by	IN
cord-296585-yfh5d4io	390	12	Lu	Lu	NNP
cord-296585-yfh5d4io	390	13	et	et	FW
cord-296585-yfh5d4io	390	14	al	al	NNP
cord-296585-yfh5d4io	390	15	.	.	NNP
cord-296585-yfh5d4io	390	16	reported	report	VBD
cord-296585-yfh5d4io	390	17	that	that	IN
cord-296585-yfh5d4io	390	18	NTHi	NTHi	VBZ
cord-296585-yfh5d4io	390	19	infection	infection	NN
cord-296585-yfh5d4io	390	20	causes	cause	VBZ
cord-296585-yfh5d4io	390	21	increased	increase	VBN
cord-296585-yfh5d4io	390	22	production	production	NN
cord-296585-yfh5d4io	390	23	of	of	IN
cord-296585-yfh5d4io	390	24	airway	airway	NN
cord-296585-yfh5d4io	390	25	type	type	NN
cord-296585-yfh5d4io	390	26	1	1	CD
cord-296585-yfh5d4io	390	27	interferon	interferon	NN
cord-296585-yfh5d4io	390	28	(	(	-LRB-
cord-296585-yfh5d4io	390	29	1-IFN	1-ifn	CD
cord-296585-yfh5d4io	390	30	)	)	-RRB-
cord-296585-yfh5d4io	390	31	(	(	-LRB-
cord-296585-yfh5d4io	390	32	271	271	CD
cord-296585-yfh5d4io	390	33	)	)	-RRB-
cord-296585-yfh5d4io	390	34	.	.	.
cord-296585-yfh5d4io	391	1	It	-PRON-	PRP
cord-296585-yfh5d4io	391	2	was	be	VBD
cord-296585-yfh5d4io	391	3	further	further	RB
cord-296585-yfh5d4io	391	4	reported	report	VBN
cord-296585-yfh5d4io	391	5	that	that	IN
cord-296585-yfh5d4io	391	6	DNA	DNA	NNP
cord-296585-yfh5d4io	391	7	of	of	IN
cord-296585-yfh5d4io	391	8	NTHi	NTHi	NNS
cord-296585-yfh5d4io	391	9	acts	act	VBZ
cord-296585-yfh5d4io	391	10	as	as	IN
cord-296585-yfh5d4io	391	11	a	a	DT
cord-296585-yfh5d4io	391	12	PAMP	pamp	NN
cord-296585-yfh5d4io	391	13	in	in	IN
cord-296585-yfh5d4io	391	14	stimulating	stimulate	VBG
cord-296585-yfh5d4io	391	15	the	the	DT
cord-296585-yfh5d4io	391	16	STING	sting	NN
cord-296585-yfh5d4io	391	17	/	/	SYM
cord-296585-yfh5d4io	391	18	TBK1	TBK1	NNP
cord-296585-yfh5d4io	391	19	/	/	SYM
cord-296585-yfh5d4io	391	20	IRF3	IRF3	NNP
cord-296585-yfh5d4io	391	21	pathway	pathway	NN
cord-296585-yfh5d4io	391	22	,	,	,
cord-296585-yfh5d4io	391	23	and	and	CC
cord-296585-yfh5d4io	391	24	thus	thus	RB
cord-296585-yfh5d4io	391	25	the	the	DT
cord-296585-yfh5d4io	391	26	production	production	NN
cord-296585-yfh5d4io	391	27	of	of	IN
cord-296585-yfh5d4io	391	28	1-IFN	1-ifn	CD
cord-296585-yfh5d4io	391	29	.	.	.
cord-296585-yfh5d4io	392	1	The	the	DT
cord-296585-yfh5d4io	392	2	impact	impact	NN
cord-296585-yfh5d4io	392	3	of	of	IN
cord-296585-yfh5d4io	392	4	the	the	DT
cord-296585-yfh5d4io	392	5	bacterial	bacterial	JJ
cord-296585-yfh5d4io	392	6	DNAinduced	dnainduce	VBN
cord-296585-yfh5d4io	392	7	1-IFN	1-ifn	CD
cord-296585-yfh5d4io	392	8	in	in	IN
cord-296585-yfh5d4io	392	9	host	host	NN
cord-296585-yfh5d4io	392	10	immune	immune	JJ
cord-296585-yfh5d4io	392	11	/	/	SYM
cord-296585-yfh5d4io	392	12	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	392	13	response	response	NN
cord-296585-yfh5d4io	392	14	,	,	,
cord-296585-yfh5d4io	392	15	which	which	WDT
cord-296585-yfh5d4io	392	16	may	may	MD
cord-296585-yfh5d4io	392	17	potentially	potentially	RB
cord-296585-yfh5d4io	392	18	induce	induce	VB
cord-296585-yfh5d4io	392	19	a	a	DT
cord-296585-yfh5d4io	392	20	Th1	th1	CD
cord-296585-yfh5d4io	392	21	/	/	SYM
cord-296585-yfh5d4io	392	22	Tc1	tc1	CD
cord-296585-yfh5d4io	392	23	response	response	NN
cord-296585-yfh5d4io	392	24	requires	require	VBZ
cord-296585-yfh5d4io	392	25	further	further	JJ
cord-296585-yfh5d4io	392	26	investigations	investigation	NNS
cord-296585-yfh5d4io	392	27	.	.	.
cord-296585-yfh5d4io	393	1	COPD	COPD	NNP
cord-296585-yfh5d4io	393	2	patients	patient	NNS
cord-296585-yfh5d4io	393	3	also	also	RB
cord-296585-yfh5d4io	393	4	have	have	VBP
cord-296585-yfh5d4io	393	5	abnormally	abnormally	RB
cord-296585-yfh5d4io	393	6	higher	high	JJR
cord-296585-yfh5d4io	393	7	number	number	NN
cord-296585-yfh5d4io	393	8	of	of	IN
cord-296585-yfh5d4io	393	9	Treg	Treg	NNP
cord-296585-yfh5d4io	393	10	cells	cell	NNS
cord-296585-yfh5d4io	393	11	,	,	,
cord-296585-yfh5d4io	393	12	myeloid	myeloid	NN
cord-296585-yfh5d4io	393	13	-	-	HYPH
cord-296585-yfh5d4io	393	14	derived	derive	VBN
cord-296585-yfh5d4io	393	15	suppressor	suppressor	NN
cord-296585-yfh5d4io	393	16	cells	cell	NNS
cord-296585-yfh5d4io	393	17	(	(	-LRB-
cord-296585-yfh5d4io	393	18	MDSC	MDSC	NNP
cord-296585-yfh5d4io	393	19	)	)	-RRB-
cord-296585-yfh5d4io	393	20	,	,	,
cord-296585-yfh5d4io	393	21	and	and	CC
cord-296585-yfh5d4io	393	22	exhausted	exhausted	JJ
cord-296585-yfh5d4io	393	23	effector	effector	NN
cord-296585-yfh5d4io	393	24	T	t	NN
cord-296585-yfh5d4io	393	25	cells	cell	NNS
cord-296585-yfh5d4io	393	26	(	(	-LRB-
cord-296585-yfh5d4io	393	27	PD-1	PD-1	NNP
cord-296585-yfh5d4io	393	28	+	+	CC
cord-296585-yfh5d4io	393	29	)	)	-RRB-
cord-296585-yfh5d4io	393	30	than	than	IN
cord-296585-yfh5d4io	393	31	healthy	healthy	JJ
cord-296585-yfh5d4io	393	32	individuals	individual	NNS
cord-296585-yfh5d4io	393	33	(	(	-LRB-
cord-296585-yfh5d4io	393	34	272	272	CD
cord-296585-yfh5d4io	393	35	,	,	,
cord-296585-yfh5d4io	393	36	273	273	CD
cord-296585-yfh5d4io	393	37	)	)	-RRB-
cord-296585-yfh5d4io	393	38	.	.	.
cord-296585-yfh5d4io	394	1	Cigarette	cigarette	NN
cord-296585-yfh5d4io	394	2	smoke	smoke	NN
cord-296585-yfh5d4io	394	3	-	-	HYPH
cord-296585-yfh5d4io	394	4	induced	induce	VBN
cord-296585-yfh5d4io	394	5	anti	anti	JJ
cord-296585-yfh5d4io	394	6	-	-	JJ
cord-296585-yfh5d4io	394	7	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	394	8	activity	activity	NN
cord-296585-yfh5d4io	394	9	of	of	IN
cord-296585-yfh5d4io	394	10	Tregs	Tregs	NNP
cord-296585-yfh5d4io	394	11	in	in	IN
cord-296585-yfh5d4io	394	12	a	a	DT
cord-296585-yfh5d4io	394	13	COPD	COPD	NNP
cord-296585-yfh5d4io	394	14	model	model	NN
cord-296585-yfh5d4io	394	15	is	be	VBZ
cord-296585-yfh5d4io	394	16	further	far	RBR
cord-296585-yfh5d4io	394	17	suppressed	suppress	VBN
cord-296585-yfh5d4io	394	18	by	by	IN
cord-296585-yfh5d4io	394	19	NTHi	NTHi	NNS
cord-296585-yfh5d4io	394	20	infection	infection	NN
cord-296585-yfh5d4io	394	21	.	.	.
cord-296585-yfh5d4io	395	1	The	the	DT
cord-296585-yfh5d4io	395	2	pathogen	pathogen	NN
cord-296585-yfh5d4io	395	3	causes	cause	VBZ
cord-296585-yfh5d4io	395	4	downregulation	downregulation	NN
cord-296585-yfh5d4io	395	5	of	of	IN
cord-296585-yfh5d4io	395	6	Foxp3	foxp3	JJ
cord-296585-yfh5d4io	395	7	(	(	-LRB-
cord-296585-yfh5d4io	395	8	biomarker	biomarker	NN
cord-296585-yfh5d4io	395	9	of	of	IN
cord-296585-yfh5d4io	395	10	Tregs	Tregs	NNP
cord-296585-yfh5d4io	395	11	)	)	-RRB-
cord-296585-yfh5d4io	395	12	,	,	,
cord-296585-yfh5d4io	395	13	and	and	CC
cord-296585-yfh5d4io	395	14	thus	thus	RB
cord-296585-yfh5d4io	395	15	impairs	impair	VBZ
cord-296585-yfh5d4io	395	16	the	the	DT
cord-296585-yfh5d4io	395	17	anti	anti	JJ
cord-296585-yfh5d4io	395	18	-	-	JJ
cord-296585-yfh5d4io	395	19	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	395	20	/	/	HYPH
cord-296585-yfh5d4io	395	21	pro	pro	JJ
cord-296585-yfh5d4io	395	22	-	-	JJ
cord-296585-yfh5d4io	395	23	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	395	24	balance	balance	NN
cord-296585-yfh5d4io	395	25	of	of	IN
cord-296585-yfh5d4io	395	26	Tregs	Tregs	NNP
cord-296585-yfh5d4io	395	27	(	(	-LRB-
cord-296585-yfh5d4io	395	28	273	273	CD
cord-296585-yfh5d4io	395	29	,	,	,
cord-296585-yfh5d4io	395	30	274	274	CD
cord-296585-yfh5d4io	395	31	)	)	-RRB-
cord-296585-yfh5d4io	395	32	.	.	.
cord-296585-yfh5d4io	396	1	This	this	DT
cord-296585-yfh5d4io	396	2	may	may	MD
cord-296585-yfh5d4io	396	3	lead	lead	VB
cord-296585-yfh5d4io	396	4	to	to	IN
cord-296585-yfh5d4io	396	5	the	the	DT
cord-296585-yfh5d4io	396	6	extensive	extensive	JJ
cord-296585-yfh5d4io	396	7	immunosuppressive	immunosuppressive	JJ
cord-296585-yfh5d4io	396	8	activity	activity	NN
cord-296585-yfh5d4io	396	9	by	by	IN
cord-296585-yfh5d4io	396	10	Tregs	Tregs	NNP
cord-296585-yfh5d4io	396	11	on	on	IN
cord-296585-yfh5d4io	396	12	the	the	DT
cord-296585-yfh5d4io	396	13	proliferation	proliferation	NN
cord-296585-yfh5d4io	396	14	of	of	IN
cord-296585-yfh5d4io	396	15	NTHi	NTHi	NNS
cord-296585-yfh5d4io	396	16	P6-specific	p6-specific	JJ
cord-296585-yfh5d4io	396	17	effector	effector	NN
cord-296585-yfh5d4io	396	18	T	t	NN
cord-296585-yfh5d4io	396	19	cells	cell	NNS
cord-296585-yfh5d4io	396	20	,	,	,
cord-296585-yfh5d4io	396	21	causing	cause	VBG
cord-296585-yfh5d4io	396	22	a	a	DT
cord-296585-yfh5d4io	396	23	diminished	diminished	JJ
cord-296585-yfh5d4io	396	24	response	response	NN
cord-296585-yfh5d4io	396	25	of	of	IN
cord-296585-yfh5d4io	396	26	effector	effector	NN
cord-296585-yfh5d4io	396	27	T	t	NN
cord-296585-yfh5d4io	396	28	cells	cell	NNS
cord-296585-yfh5d4io	396	29	to	to	TO
cord-296585-yfh5d4io	396	30	sputum	sputum	VB
cord-296585-yfh5d4io	396	31	IL-6	IL-6	NNP
cord-296585-yfh5d4io	396	32	and	and	CC
cord-296585-yfh5d4io	396	33	IL-8	IL-8	NNP
cord-296585-yfh5d4io	396	34	induction	induction	NN
cord-296585-yfh5d4io	396	35	,	,	,
cord-296585-yfh5d4io	396	36	and	and	CC
cord-296585-yfh5d4io	396	37	increased	increase	VBN
cord-296585-yfh5d4io	396	38	levels	level	NNS
cord-296585-yfh5d4io	396	39	of	of	IN
cord-296585-yfh5d4io	396	40	IL-10	IL-10	NNP
cord-296585-yfh5d4io	396	41	and	and	CC
cord-296585-yfh5d4io	396	42	TGF	TGF	NNP
cord-296585-yfh5d4io	396	43	-	-	HYPH
cord-296585-yfh5d4io	396	44	β1	β1	NNP
cord-296585-yfh5d4io	396	45	(	(	-LRB-
cord-296585-yfh5d4io	396	46	272	272	CD
cord-296585-yfh5d4io	396	47	,	,	,
cord-296585-yfh5d4io	396	48	275	275	CD
cord-296585-yfh5d4io	396	49	)	)	-RRB-
cord-296585-yfh5d4io	396	50	.	.	.
cord-296585-yfh5d4io	397	1	Recently	recently	RB
cord-296585-yfh5d4io	397	2	,	,	,
cord-296585-yfh5d4io	397	3	it	-PRON-	PRP
cord-296585-yfh5d4io	397	4	has	have	VBZ
cord-296585-yfh5d4io	397	5	been	be	VBN
cord-296585-yfh5d4io	397	6	reported	report	VBN
cord-296585-yfh5d4io	397	7	that	that	IN
cord-296585-yfh5d4io	397	8	mucosal	mucosal	NN
cord-296585-yfh5d4io	397	9	-	-	HYPH
cord-296585-yfh5d4io	397	10	associated	associated	JJ
cord-296585-yfh5d4io	397	11	invariant	invariant	JJ
cord-296585-yfh5d4io	397	12	T	t	NN
cord-296585-yfh5d4io	397	13	cells	cell	NNS
cord-296585-yfh5d4io	397	14	(	(	-LRB-
cord-296585-yfh5d4io	397	15	MAIT	MAIT	NNP
cord-296585-yfh5d4io	397	16	)	)	-RRB-
cord-296585-yfh5d4io	397	17	from	from	IN
cord-296585-yfh5d4io	397	18	COPD	COPD	NNP
cord-296585-yfh5d4io	397	19	patients	patient	NNS
cord-296585-yfh5d4io	397	20	are	be	VBP
cord-296585-yfh5d4io	397	21	more	more	RBR
cord-296585-yfh5d4io	397	22	effective	effective	JJ
cord-296585-yfh5d4io	397	23	in	in	IN
cord-296585-yfh5d4io	397	24	response	response	NN
cord-296585-yfh5d4io	397	25	to	to	IN
cord-296585-yfh5d4io	397	26	NTHi	NTHi	VBZ
cord-296585-yfh5d4io	397	27	stimulation	stimulation	NN
cord-296585-yfh5d4io	397	28	and	and	CC
cord-296585-yfh5d4io	397	29	thus	thus	RB
cord-296585-yfh5d4io	397	30	produce	produce	VB
cord-296585-yfh5d4io	397	31	increased	increase	VBN
cord-296585-yfh5d4io	397	32	levels	level	NNS
cord-296585-yfh5d4io	397	33	of	of	IN
cord-296585-yfh5d4io	397	34	IFN	IFN	NNP
cord-296585-yfh5d4io	397	35	-	-	HYPH
cord-296585-yfh5d4io	397	36	γ	γ	NNP
cord-296585-yfh5d4io	397	37	,	,	,
cord-296585-yfh5d4io	397	38	3-	3-	NNP
cord-296585-yfh5d4io	397	39	,	,	,
cord-296585-yfh5d4io	397	40	to	to	IN
cord-296585-yfh5d4io	397	41	10-fold	10-fold	CD
cord-296585-yfh5d4io	397	42	more	more	JJR
cord-296585-yfh5d4io	397	43	than	than	IN
cord-296585-yfh5d4io	397	44	the	the	DT
cord-296585-yfh5d4io	397	45	COPD	COPD	NNP
cord-296585-yfh5d4io	397	46	Th	Th	NNP
cord-296585-yfh5d4io	397	47	(	(	-LRB-
cord-296585-yfh5d4io	397	48	CD4	CD4	NNP
cord-296585-yfh5d4io	397	49	+	+	CC
cord-296585-yfh5d4io	397	50	)	)	-RRB-
cord-296585-yfh5d4io	397	51	and	and	CC
cord-296585-yfh5d4io	397	52	Tc	Tc	NNP
cord-296585-yfh5d4io	397	53	(	(	-LRB-
cord-296585-yfh5d4io	397	54	CD8	CD8	NNP
cord-296585-yfh5d4io	397	55	+	+	SYM
cord-296585-yfh5d4io	397	56	)	)	-RRB-
cord-296585-yfh5d4io	397	57	cells	cell	NNS
cord-296585-yfh5d4io	397	58	(	(	-LRB-
cord-296585-yfh5d4io	397	59	276	276	CD
cord-296585-yfh5d4io	397	60	)	)	-RRB-
cord-296585-yfh5d4io	397	61	.	.	.
cord-296585-yfh5d4io	398	1	However	however	RB
cord-296585-yfh5d4io	398	2	,	,	,
cord-296585-yfh5d4io	398	3	the	the	DT
cord-296585-yfh5d4io	398	4	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	398	5	MAIT	MAIT	NNP
cord-296585-yfh5d4io	398	6	cell	cell	NN
cord-296585-yfh5d4io	398	7	immune	immune	JJ
cord-296585-yfh5d4io	398	8	responses	response	NNS
cord-296585-yfh5d4io	398	9	are	be	VBP
cord-296585-yfh5d4io	398	10	compromised	compromise	VBN
cord-296585-yfh5d4io	398	11	in	in	IN
cord-296585-yfh5d4io	398	12	the	the	DT
cord-296585-yfh5d4io	398	13	presence	presence	NN
cord-296585-yfh5d4io	398	14	of	of	IN
cord-296585-yfh5d4io	398	15	corticosteroids	corticosteroid	NNS
cord-296585-yfh5d4io	398	16	that	that	WDT
cord-296585-yfh5d4io	398	17	are	be	VBP
cord-296585-yfh5d4io	398	18	commonly	commonly	RB
cord-296585-yfh5d4io	398	19	used	use	VBN
cord-296585-yfh5d4io	398	20	for	for	IN
cord-296585-yfh5d4io	398	21	the	the	DT
cord-296585-yfh5d4io	398	22	treatment	treatment	NN
cord-296585-yfh5d4io	398	23	of	of	IN
cord-296585-yfh5d4io	398	24	COPD	COPD	NNP
cord-296585-yfh5d4io	398	25	.	.	.
cord-296585-yfh5d4io	399	1	This	this	DT
cord-296585-yfh5d4io	399	2	may	may	MD
cord-296585-yfh5d4io	399	3	potentially	potentially	RB
cord-296585-yfh5d4io	399	4	prone	prone	VB
cord-296585-yfh5d4io	399	5	the	the	DT
cord-296585-yfh5d4io	399	6	T	T	NNP
cord-296585-yfh5d4io	399	7	cell	cell	NN
cord-296585-yfh5d4io	399	8	-	-	HYPH
cord-296585-yfh5d4io	399	9	mediated	mediate	VBN
cord-296585-yfh5d4io	399	10	immunity	immunity	NN
cord-296585-yfh5d4io	399	11	to	to	IN
cord-296585-yfh5d4io	399	12	a	a	DT
cord-296585-yfh5d4io	399	13	Th2	th2	CD
cord-296585-yfh5d4io	399	14	/	/	SYM
cord-296585-yfh5d4io	399	15	Tc2	tc2	NN
cord-296585-yfh5d4io	399	16	response	response	NN
cord-296585-yfh5d4io	399	17	in	in	IN
cord-296585-yfh5d4io	399	18	COPD	COPD	NNP
cord-296585-yfh5d4io	399	19	patients	patient	NNS
cord-296585-yfh5d4io	399	20	treated	treat	VBN
cord-296585-yfh5d4io	399	21	with	with	IN
cord-296585-yfh5d4io	399	22	corticosteroids	corticosteroid	NNS
cord-296585-yfh5d4io	399	23	(	(	-LRB-
cord-296585-yfh5d4io	399	24	277	277	CD
cord-296585-yfh5d4io	399	25	)	)	-RRB-
cord-296585-yfh5d4io	399	26	.	.	.
cord-296585-yfh5d4io	400	1	Interestingly	interestingly	RB
cord-296585-yfh5d4io	400	2	,	,	,
cord-296585-yfh5d4io	400	3	antigen	antigen	NN
cord-296585-yfh5d4io	400	4	-	-	HYPH
cord-296585-yfh5d4io	400	5	specific	specific	JJ
cord-296585-yfh5d4io	400	6	Th17	th17	CD
cord-296585-yfh5d4io	400	7	cells	cell	NNS
cord-296585-yfh5d4io	400	8	from	from	IN
cord-296585-yfh5d4io	400	9	NTHi	NTHi	NNS
cord-296585-yfh5d4io	400	10	-	-	HYPH
cord-296585-yfh5d4io	400	11	immunized	immunize	VBN
cord-296585-yfh5d4io	400	12	non	non	JJ
cord-296585-yfh5d4io	400	13	-	-	JJ
cord-296585-yfh5d4io	400	14	COPD	COPD	NNP
cord-296585-yfh5d4io	400	15	mice	mouse	NNS
cord-296585-yfh5d4io	400	16	model	model	NN
cord-296585-yfh5d4io	400	17	recognize	recognize	VBP
cord-296585-yfh5d4io	400	18	both	both	CC
cord-296585-yfh5d4io	400	19	homologous	homologous	JJ
cord-296585-yfh5d4io	400	20	and	and	CC
cord-296585-yfh5d4io	400	21	heterologous	heterologous	JJ
cord-296585-yfh5d4io	400	22	strains	strain	NNS
cord-296585-yfh5d4io	400	23	of	of	IN
cord-296585-yfh5d4io	400	24	NTHi	NTHi	NNS
cord-296585-yfh5d4io	400	25	,	,	,
cord-296585-yfh5d4io	400	26	and	and	CC
cord-296585-yfh5d4io	400	27	are	be	VBP
cord-296585-yfh5d4io	400	28	able	able	JJ
cord-296585-yfh5d4io	400	29	to	to	TO
cord-296585-yfh5d4io	400	30	confer	confer	VB
cord-296585-yfh5d4io	400	31	protection	protection	NN
cord-296585-yfh5d4io	400	32	upon	upon	IN
cord-296585-yfh5d4io	400	33	adoptive	adoptive	JJ
cord-296585-yfh5d4io	400	34	transfer	transfer	NN
cord-296585-yfh5d4io	400	35	(	(	-LRB-
cord-296585-yfh5d4io	400	36	278	278	CD
cord-296585-yfh5d4io	400	37	)	)	-RRB-
cord-296585-yfh5d4io	400	38	.	.	.
cord-296585-yfh5d4io	401	1	However	however	RB
cord-296585-yfh5d4io	401	2	,	,	,
cord-296585-yfh5d4io	401	3	it	-PRON-	PRP
cord-296585-yfh5d4io	401	4	is	be	VBZ
cord-296585-yfh5d4io	401	5	unclear	unclear	JJ
cord-296585-yfh5d4io	401	6	whether	whether	IN
cord-296585-yfh5d4io	401	7	the	the	DT
cord-296585-yfh5d4io	401	8	Th17	Th17	NNP
cord-296585-yfh5d4io	401	9	cell	cell	NN
cord-296585-yfh5d4io	401	10	which	which	WDT
cord-296585-yfh5d4io	401	11	is	be	VBZ
cord-296585-yfh5d4io	401	12	prone	prone	JJ
cord-296585-yfh5d4io	401	13	to	to	IN
cord-296585-yfh5d4io	401	14	the	the	DT
cord-296585-yfh5d4io	401	15	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	401	16	response	response	NN
cord-296585-yfh5d4io	401	17	could	could	MD
cord-296585-yfh5d4io	401	18	be	be	VB
cord-296585-yfh5d4io	401	19	"	"	``
cord-296585-yfh5d4io	401	20	trained	train	VBN
cord-296585-yfh5d4io	401	21	"	"	''
cord-296585-yfh5d4io	401	22	to	to	TO
cord-296585-yfh5d4io	401	23	counteract	counteract	VB
cord-296585-yfh5d4io	401	24	the	the	DT
cord-296585-yfh5d4io	401	25	NTHi	NTHi	NNS
cord-296585-yfh5d4io	401	26	infection	infection	NN
cord-296585-yfh5d4io	401	27	in	in	IN
cord-296585-yfh5d4io	401	28	COPD	COPD	NNP
cord-296585-yfh5d4io	401	29	patients	patient	NNS
cord-296585-yfh5d4io	401	30	,	,	,
cord-296585-yfh5d4io	401	31	particularly	particularly	RB
cord-296585-yfh5d4io	401	32	during	during	IN
cord-296585-yfh5d4io	401	33	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	401	34	.	.	.
cord-296585-yfh5d4io	402	1	During	during	IN
cord-296585-yfh5d4io	402	2	the	the	DT
cord-296585-yfh5d4io	402	3	systemic	systemic	JJ
cord-296585-yfh5d4io	402	4	humoral	humoral	JJ
cord-296585-yfh5d4io	402	5	immune	immune	JJ
cord-296585-yfh5d4io	402	6	response	response	NN
cord-296585-yfh5d4io	402	7	in	in	IN
cord-296585-yfh5d4io	402	8	NTHiinfected	NTHiinfected	NNP
cord-296585-yfh5d4io	402	9	COPD	COPD	NNP
cord-296585-yfh5d4io	402	10	patients	patient	NNS
cord-296585-yfh5d4io	402	11	,	,	,
cord-296585-yfh5d4io	402	12	greater	great	JJR
cord-296585-yfh5d4io	402	13	concentrations	concentration	NNS
cord-296585-yfh5d4io	402	14	of	of	IN
cord-296585-yfh5d4io	402	15	NTHi	NTHi	NNS
cord-296585-yfh5d4io	402	16	-	-	HYPH
cord-296585-yfh5d4io	402	17	specific	specific	JJ
cord-296585-yfh5d4io	402	18	IgG	IgG	NNP
cord-296585-yfh5d4io	402	19	,	,	,
cord-296585-yfh5d4io	402	20	IgA	IgA	NNP
cord-296585-yfh5d4io	402	21	,	,	,
cord-296585-yfh5d4io	402	22	IgM	IgM	NNP
cord-296585-yfh5d4io	402	23	,	,	,
cord-296585-yfh5d4io	402	24	and	and	CC
cord-296585-yfh5d4io	402	25	IgE	IgE	NNP
cord-296585-yfh5d4io	402	26	serum	serum	NN
cord-296585-yfh5d4io	402	27	antibodies	antibody	NNS
cord-296585-yfh5d4io	402	28	are	be	VBP
cord-296585-yfh5d4io	402	29	produced	produce	VBN
cord-296585-yfh5d4io	402	30	compared	compare	VBN
cord-296585-yfh5d4io	402	31	to	to	IN
cord-296585-yfh5d4io	402	32	non	non	JJ
cord-296585-yfh5d4io	402	33	-	-	JJ
cord-296585-yfh5d4io	402	34	infected	infected	JJ
cord-296585-yfh5d4io	402	35	controls	control	NNS
cord-296585-yfh5d4io	402	36	(	(	-LRB-
cord-296585-yfh5d4io	402	37	12	12	CD
cord-296585-yfh5d4io	402	38	,	,	,
cord-296585-yfh5d4io	402	39	(	(	-LRB-
cord-296585-yfh5d4io	402	40	279	279	CD
cord-296585-yfh5d4io	402	41	)	)	-RRB-
cord-296585-yfh5d4io	402	42	(	(	-LRB-
cord-296585-yfh5d4io	402	43	280	280	CD
cord-296585-yfh5d4io	402	44	)	)	-RRB-
cord-296585-yfh5d4io	402	45	(	(	-LRB-
cord-296585-yfh5d4io	402	46	281	281	CD
cord-296585-yfh5d4io	402	47	)	)	-RRB-
cord-296585-yfh5d4io	402	48	.	.	.
cord-296585-yfh5d4io	403	1	Some	some	DT
cord-296585-yfh5d4io	403	2	of	of	IN
cord-296585-yfh5d4io	403	3	the	the	DT
cord-296585-yfh5d4io	403	4	NTHispecific	nthispecific	JJ
cord-296585-yfh5d4io	403	5	serum	serum	NN
cord-296585-yfh5d4io	403	6	immunoglobulins	immunoglobulin	NNS
cord-296585-yfh5d4io	403	7	are	be	VBP
cord-296585-yfh5d4io	403	8	specific	specific	JJ
cord-296585-yfh5d4io	403	9	to	to	IN
cord-296585-yfh5d4io	403	10	P2	P2	NNP
cord-296585-yfh5d4io	403	11	,	,	,
cord-296585-yfh5d4io	403	12	P5	p5	NN
cord-296585-yfh5d4io	403	13	,	,	,
cord-296585-yfh5d4io	403	14	and	and	CC
cord-296585-yfh5d4io	403	15	P6	p6	NN
cord-296585-yfh5d4io	403	16	(	(	-LRB-
cord-296585-yfh5d4io	403	17	12	12	CD
cord-296585-yfh5d4io	403	18	,	,	,
cord-296585-yfh5d4io	403	19	282	282	CD
cord-296585-yfh5d4io	403	20	,	,	,
cord-296585-yfh5d4io	403	21	283	283	CD
cord-296585-yfh5d4io	403	22	)	)	-RRB-
cord-296585-yfh5d4io	403	23	.	.	.
cord-296585-yfh5d4io	404	1	However	however	RB
cord-296585-yfh5d4io	404	2	,	,	,
cord-296585-yfh5d4io	404	3	decreased	decrease	VBD
cord-296585-yfh5d4io	404	4	mucosal	mucosal	JJ
cord-296585-yfh5d4io	404	5	antibodies	antibody	NNS
cord-296585-yfh5d4io	404	6	associated	associate	VBN
cord-296585-yfh5d4io	404	7	with	with	IN
cord-296585-yfh5d4io	404	8	sIgA	sIgA	NNS
cord-296585-yfh5d4io	404	9	deficiency	deficiency	NN
cord-296585-yfh5d4io	404	10	,	,	,
cord-296585-yfh5d4io	404	11	or	or	CC
cord-296585-yfh5d4io	404	12	decreased	decrease	VBD
cord-296585-yfh5d4io	404	13	total	total	JJ
cord-296585-yfh5d4io	404	14	IgG	igg	NN
cord-296585-yfh5d4io	404	15	in	in	IN
cord-296585-yfh5d4io	404	16	the	the	DT
cord-296585-yfh5d4io	404	17	small	small	JJ
cord-296585-yfh5d4io	404	18	airways	airway	NNS
cord-296585-yfh5d4io	404	19	have	have	VBP
cord-296585-yfh5d4io	404	20	been	be	VBN
cord-296585-yfh5d4io	404	21	reported	report	VBN
cord-296585-yfh5d4io	404	22	in	in	IN
cord-296585-yfh5d4io	404	23	COPD	COPD	NNP
cord-296585-yfh5d4io	404	24	patients	patient	NNS
cord-296585-yfh5d4io	404	25	,	,	,
cord-296585-yfh5d4io	404	26	and	and	CC
cord-296585-yfh5d4io	404	27	might	may	MD
cord-296585-yfh5d4io	404	28	be	be	VB
cord-296585-yfh5d4io	404	29	associated	associate	VBN
cord-296585-yfh5d4io	404	30	with	with	IN
cord-296585-yfh5d4io	404	31	disease	disease	NN
cord-296585-yfh5d4io	404	32	severity	severity	NN
cord-296585-yfh5d4io	404	33	(	(	-LRB-
cord-296585-yfh5d4io	404	34	283	283	CD
cord-296585-yfh5d4io	404	35	,	,	,
cord-296585-yfh5d4io	404	36	284	284	CD
cord-296585-yfh5d4io	404	37	)	)	-RRB-
cord-296585-yfh5d4io	404	38	.	.	.
cord-296585-yfh5d4io	405	1	Importantly	importantly	RB
cord-296585-yfh5d4io	405	2	,	,	,
cord-296585-yfh5d4io	405	3	NTHi	NTHi	NNS
cord-296585-yfh5d4io	405	4	-	-	HYPH
cord-296585-yfh5d4io	405	5	specific	specific	JJ
cord-296585-yfh5d4io	405	6	mucosal	mucosal	JJ
cord-296585-yfh5d4io	405	7	sIgA	sIgA	NNS
cord-296585-yfh5d4io	405	8	has	have	VBZ
cord-296585-yfh5d4io	405	9	been	be	VBN
cord-296585-yfh5d4io	405	10	found	find	VBN
cord-296585-yfh5d4io	405	11	to	to	TO
cord-296585-yfh5d4io	405	12	be	be	VB
cord-296585-yfh5d4io	405	13	lower	low	JJR
cord-296585-yfh5d4io	405	14	in	in	IN
cord-296585-yfh5d4io	405	15	the	the	DT
cord-296585-yfh5d4io	405	16	airways	airways	NNPS
cord-296585-yfh5d4io	405	17	of	of	IN
cord-296585-yfh5d4io	405	18	NTHi	NTHi	NNPS
cord-296585-yfh5d4io	405	19	-	-	HYPH
cord-296585-yfh5d4io	405	20	infected	infect	VBN
cord-296585-yfh5d4io	405	21	COPD	COPD	NNP
cord-296585-yfh5d4io	405	22	patients	patient	NNS
cord-296585-yfh5d4io	405	23	than	than	IN
cord-296585-yfh5d4io	405	24	the	the	DT
cord-296585-yfh5d4io	405	25	non	non	JJ
cord-296585-yfh5d4io	405	26	-	-	JJ
cord-296585-yfh5d4io	405	27	colonized	colonize	VBN
cord-296585-yfh5d4io	405	28	patients	patient	NNS
cord-296585-yfh5d4io	405	29	(	(	-LRB-
cord-296585-yfh5d4io	405	30	285	285	CD
cord-296585-yfh5d4io	405	31	,	,	,
cord-296585-yfh5d4io	405	32	286	286	CD
cord-296585-yfh5d4io	405	33	)	)	-RRB-
cord-296585-yfh5d4io	405	34	.	.	.
cord-296585-yfh5d4io	406	1	The	the	DT
cord-296585-yfh5d4io	406	2	epithelial	epithelial	JJ
cord-296585-yfh5d4io	406	3	polymeric	polymeric	JJ
cord-296585-yfh5d4io	406	4	immunoglobulin	immunoglobulin	NN
cord-296585-yfh5d4io	406	5	receptor	receptor	NN
cord-296585-yfh5d4io	406	6	(	(	-LRB-
cord-296585-yfh5d4io	406	7	pIgR	pigr	NN
cord-296585-yfh5d4io	406	8	)	)	-RRB-
cord-296585-yfh5d4io	406	9	is	be	VBZ
cord-296585-yfh5d4io	406	10	essential	essential	JJ
cord-296585-yfh5d4io	406	11	for	for	IN
cord-296585-yfh5d4io	406	12	the	the	DT
cord-296585-yfh5d4io	406	13	generation	generation	NN
cord-296585-yfh5d4io	406	14	of	of	IN
cord-296585-yfh5d4io	406	15	mucosal	mucosal	NN
cord-296585-yfh5d4io	406	16	sIgA.	sIgA.	.
cord-296585-yfh5d4io	407	1	It	-PRON-	PRP
cord-296585-yfh5d4io	407	2	is	be	VBZ
cord-296585-yfh5d4io	407	3	,	,	,
cord-296585-yfh5d4io	407	4	however	however	RB
cord-296585-yfh5d4io	407	5	,	,	,
cord-296585-yfh5d4io	407	6	downregulated	downregulate	VBN
cord-296585-yfh5d4io	407	7	in	in	IN
cord-296585-yfh5d4io	407	8	COPD	COPD	NNP
cord-296585-yfh5d4io	407	9	patients	patient	NNS
cord-296585-yfh5d4io	407	10	with	with	IN
cord-296585-yfh5d4io	407	11	a	a	DT
cord-296585-yfh5d4io	407	12	positive	positive	JJ
cord-296585-yfh5d4io	407	13	correlation	correlation	NN
cord-296585-yfh5d4io	407	14	to	to	IN
cord-296585-yfh5d4io	407	15	disease	disease	NN
cord-296585-yfh5d4io	407	16	severity	severity	NN
cord-296585-yfh5d4io	407	17	and	and	CC
cord-296585-yfh5d4io	407	18	increased	increase	VBN
cord-296585-yfh5d4io	407	19	level	level	NN
cord-296585-yfh5d4io	407	20	of	of	IN
cord-296585-yfh5d4io	407	21	TGF	TGF	NNP
cord-296585-yfh5d4io	407	22	-	-	HYPH
cord-296585-yfh5d4io	407	23	β	β	NNP
cord-296585-yfh5d4io	407	24	(	(	-LRB-
cord-296585-yfh5d4io	407	25	287	287	CD
cord-296585-yfh5d4io	407	26	)	)	-RRB-
cord-296585-yfh5d4io	407	27	.	.	.
cord-296585-yfh5d4io	408	1	The	the	DT
cord-296585-yfh5d4io	408	2	combinatorial	combinatorial	JJ
cord-296585-yfh5d4io	408	3	effects	effect	NNS
cord-296585-yfh5d4io	408	4	of	of	IN
cord-296585-yfh5d4io	408	5	downregulated	downregulate	VBN
cord-296585-yfh5d4io	408	6	plgR	plgr	JJ
cord-296585-yfh5d4io	408	7	and	and	CC
cord-296585-yfh5d4io	408	8	elevated	elevated	JJ
cord-296585-yfh5d4io	408	9	TGF	TGF	NNP
cord-296585-yfh5d4io	408	10	-	-	HYPH
cord-296585-yfh5d4io	408	11	β1	β1	NNP
cord-296585-yfh5d4io	408	12	contribute	contribute	VBP
cord-296585-yfh5d4io	408	13	to	to	IN
cord-296585-yfh5d4io	408	14	an	an	DT
cord-296585-yfh5d4io	408	15	impaired	impaired	JJ
cord-296585-yfh5d4io	408	16	mucosal	mucosal	JJ
cord-296585-yfh5d4io	408	17	IgA	iga	NN
cord-296585-yfh5d4io	408	18	immunity	immunity	NN
cord-296585-yfh5d4io	408	19	in	in	IN
cord-296585-yfh5d4io	408	20	COPD	COPD	NNP
cord-296585-yfh5d4io	408	21	patients	patient	NNS
cord-296585-yfh5d4io	408	22	.	.	.
cord-296585-yfh5d4io	409	1	A	a	DT
cord-296585-yfh5d4io	409	2	mouse	mouse	NN
cord-296585-yfh5d4io	409	3	model	model	NN
cord-296585-yfh5d4io	409	4	lacking	lack	VBG
cord-296585-yfh5d4io	409	5	the	the	DT
cord-296585-yfh5d4io	409	6	pIgR	pigr	NN
cord-296585-yfh5d4io	409	7	(	(	-LRB-
cord-296585-yfh5d4io	409	8	−/−	−/−	NNP
cord-296585-yfh5d4io	409	9	)	)	-RRB-
cord-296585-yfh5d4io	409	10	is	be	VBZ
cord-296585-yfh5d4io	409	11	therefore	therefore	RB
cord-296585-yfh5d4io	409	12	devoid	devoid	JJ
cord-296585-yfh5d4io	409	13	of	of	IN
cord-296585-yfh5d4io	409	14	sIgA	sIgA	NNS
cord-296585-yfh5d4io	409	15	and	and	CC
cord-296585-yfh5d4io	409	16	are	be	VBP
cord-296585-yfh5d4io	409	17	susceptible	susceptible	JJ
cord-296585-yfh5d4io	409	18	to	to	IN
cord-296585-yfh5d4io	409	19	airway	airway	JJ
cord-296585-yfh5d4io	409	20	stimulation	stimulation	NN
cord-296585-yfh5d4io	409	21	by	by	IN
cord-296585-yfh5d4io	409	22	an	an	DT
cord-296585-yfh5d4io	409	23	NTHi	NTHi	NNS
cord-296585-yfh5d4io	409	24	lysate	lysate	NN
cord-296585-yfh5d4io	409	25	resulting	result	VBG
cord-296585-yfh5d4io	409	26	in	in	IN
cord-296585-yfh5d4io	409	27	increased	increase	VBN
cord-296585-yfh5d4io	409	28	inflammation	inflammation	NN
cord-296585-yfh5d4io	409	29	and	and	CC
cord-296585-yfh5d4io	409	30	airway	airway	NNP
cord-296585-yfh5d4io	409	31	neutrophilia	neutrophilia	NNP
cord-296585-yfh5d4io	409	32	.	.	.
cord-296585-yfh5d4io	410	1	Interestingly	interestingly	RB
cord-296585-yfh5d4io	410	2	,	,	,
cord-296585-yfh5d4io	410	3	introduction	introduction	NN
cord-296585-yfh5d4io	410	4	of	of	IN
cord-296585-yfh5d4io	410	5	exogenously	exogenously	RB
cord-296585-yfh5d4io	410	6	added	add	VBN
cord-296585-yfh5d4io	410	7	sIgA	sIgA	NNS
cord-296585-yfh5d4io	410	8	mitigated	mitigate	VBD
cord-296585-yfh5d4io	410	9	the	the	DT
cord-296585-yfh5d4io	410	10	airway	airway	NN
cord-296585-yfh5d4io	410	11	inflammation	inflammation	NN
cord-296585-yfh5d4io	410	12	(	(	-LRB-
cord-296585-yfh5d4io	410	13	288	288	CD
cord-296585-yfh5d4io	410	14	)	)	-RRB-
cord-296585-yfh5d4io	410	15	.	.	.
cord-296585-yfh5d4io	411	1	NTHiinfected	NTHiinfected	NNP
cord-296585-yfh5d4io	411	2	COPD	COPD	NNP
cord-296585-yfh5d4io	411	3	patients	patient	NNS
cord-296585-yfh5d4io	411	4	with	with	IN
cord-296585-yfh5d4io	411	5	greater	great	JJR
cord-296585-yfh5d4io	411	6	airway	airway	NN
cord-296585-yfh5d4io	411	7	inflammation	inflammation	NN
cord-296585-yfh5d4io	411	8	have	have	VBP
cord-296585-yfh5d4io	411	9	also	also	RB
cord-296585-yfh5d4io	411	10	decreased	decrease	VBN
cord-296585-yfh5d4io	411	11	NTHi	NTHi	NNS
cord-296585-yfh5d4io	411	12	-	-	HYPH
cord-296585-yfh5d4io	411	13	specific	specific	JJ
cord-296585-yfh5d4io	411	14	mucosal	mucosal	NN
cord-296585-yfh5d4io	411	15	IgG1	igg1	NN
cord-296585-yfh5d4io	411	16	in	in	IN
cord-296585-yfh5d4io	411	17	the	the	DT
cord-296585-yfh5d4io	411	18	BAL	bal	NN
cord-296585-yfh5d4io	411	19	fluid	fluid	NN
cord-296585-yfh5d4io	411	20	compared	compare	VBN
cord-296585-yfh5d4io	411	21	to	to	IN
cord-296585-yfh5d4io	411	22	the	the	DT
cord-296585-yfh5d4io	411	23	non	non	JJ
cord-296585-yfh5d4io	411	24	-	-	JJ
cord-296585-yfh5d4io	411	25	colonized	colonize	VBN
cord-296585-yfh5d4io	411	26	patients	patient	NNS
cord-296585-yfh5d4io	411	27	(	(	-LRB-
cord-296585-yfh5d4io	411	28	283	283	CD
cord-296585-yfh5d4io	411	29	)	)	-RRB-
cord-296585-yfh5d4io	411	30	.	.	.
cord-296585-yfh5d4io	412	1	Interestingly	interestingly	RB
cord-296585-yfh5d4io	412	2	,	,	,
cord-296585-yfh5d4io	412	3	the	the	DT
cord-296585-yfh5d4io	412	4	phenomenon	phenomenon	NN
cord-296585-yfh5d4io	412	5	with	with	IN
cord-296585-yfh5d4io	412	6	decreased	decreased	JJ
cord-296585-yfh5d4io	412	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	412	8	-	-	HYPH
cord-296585-yfh5d4io	412	9	specific	specific	JJ
cord-296585-yfh5d4io	412	10	antibodies	antibody	NNS
cord-296585-yfh5d4io	412	11	seems	seem	VBZ
cord-296585-yfh5d4io	412	12	to	to	TO
cord-296585-yfh5d4io	412	13	be	be	VB
cord-296585-yfh5d4io	412	14	restricted	restrict	VBN
cord-296585-yfh5d4io	412	15	to	to	IN
cord-296585-yfh5d4io	412	16	the	the	DT
cord-296585-yfh5d4io	412	17	airways	airway	NNS
cord-296585-yfh5d4io	412	18	,	,	,
cord-296585-yfh5d4io	412	19	since	since	IN
cord-296585-yfh5d4io	412	20	the	the	DT
cord-296585-yfh5d4io	412	21	specific	specific	JJ
cord-296585-yfh5d4io	412	22	serum	serum	NN
cord-296585-yfh5d4io	412	23	antibodies	antibody	NNS
cord-296585-yfh5d4io	412	24	are	be	VBP
cord-296585-yfh5d4io	412	25	not	not	RB
cord-296585-yfh5d4io	412	26	affected	affect	VBN
cord-296585-yfh5d4io	412	27	.	.	.
cord-296585-yfh5d4io	413	1	Therefore	therefore	RB
cord-296585-yfh5d4io	413	2	,	,	,
cord-296585-yfh5d4io	413	3	the	the	DT
cord-296585-yfh5d4io	413	4	reduced	reduce	VBN
cord-296585-yfh5d4io	413	5	mucosal	mucosal	JJ
cord-296585-yfh5d4io	413	6	IgG	igg	NN
cord-296585-yfh5d4io	413	7	is	be	VBZ
cord-296585-yfh5d4io	413	8	unlikely	unlikely	JJ
cord-296585-yfh5d4io	413	9	to	to	TO
cord-296585-yfh5d4io	413	10	be	be	VB
cord-296585-yfh5d4io	413	11	associated	associate	VBN
cord-296585-yfh5d4io	413	12	with	with	IN
cord-296585-yfh5d4io	413	13	hypogammaglobulinemia	hypogammaglobulinemia	NNP
cord-296585-yfh5d4io	413	14	(	(	-LRB-
cord-296585-yfh5d4io	413	15	IgG	IgG	NNP
cord-296585-yfh5d4io	413	16	deficiency	deficiency	NN
cord-296585-yfh5d4io	413	17	)	)	-RRB-
cord-296585-yfh5d4io	413	18	,	,	,
cord-296585-yfh5d4io	413	19	despite	despite	IN
cord-296585-yfh5d4io	413	20	the	the	DT
cord-296585-yfh5d4io	413	21	latter	latter	JJ
cord-296585-yfh5d4io	413	22	was	be	VBD
cord-296585-yfh5d4io	413	23	reported	report	VBN
cord-296585-yfh5d4io	413	24	as	as	IN
cord-296585-yfh5d4io	413	25	a	a	DT
cord-296585-yfh5d4io	413	26	contributing	contribute	VBG
cord-296585-yfh5d4io	413	27	factor	factor	NN
cord-296585-yfh5d4io	413	28	in	in	IN
cord-296585-yfh5d4io	413	29	NTHi	NTHi	NNS
cord-296585-yfh5d4io	413	30	infection	infection	NN
cord-296585-yfh5d4io	413	31	(	(	-LRB-
cord-296585-yfh5d4io	413	32	289	289	CD
cord-296585-yfh5d4io	413	33	)	)	-RRB-
cord-296585-yfh5d4io	413	34	.	.	.
cord-296585-yfh5d4io	414	1	Decreased	decrease	VBN
cord-296585-yfh5d4io	414	2	airway	airway	NNP
cord-296585-yfh5d4io	414	3	IgA	IgA	NNP
cord-296585-yfh5d4io	414	4	might	may	MD
cord-296585-yfh5d4io	414	5	be	be	VB
cord-296585-yfh5d4io	414	6	attributed	attribute	VBN
cord-296585-yfh5d4io	414	7	to	to	IN
cord-296585-yfh5d4io	414	8	the	the	DT
cord-296585-yfh5d4io	414	9	expression	expression	NN
cord-296585-yfh5d4io	414	10	of	of	IN
cord-296585-yfh5d4io	414	11	IgA	IgA	NNP
cord-296585-yfh5d4io	414	12	proteases	protease	NNS
cord-296585-yfh5d4io	414	13	by	by	IN
cord-296585-yfh5d4io	414	14	NTHi	NTHi	NNS
cord-296585-yfh5d4io	414	15	.	.	.
cord-296585-yfh5d4io	415	1	The	the	DT
cord-296585-yfh5d4io	415	2	bacterial	bacterial	JJ
cord-296585-yfh5d4io	415	3	IgA	iga	NN
cord-296585-yfh5d4io	415	4	protease	protease	NN
cord-296585-yfh5d4io	415	5	degrades	degrade	VBZ
cord-296585-yfh5d4io	415	6	the	the	DT
cord-296585-yfh5d4io	415	7	local	local	JJ
cord-296585-yfh5d4io	415	8	airway	airway	NNP
cord-296585-yfh5d4io	415	9	IgA	IgA	NNP
cord-296585-yfh5d4io	415	10	during	during	IN
cord-296585-yfh5d4io	415	11	airway	airway	NNP
cord-296585-yfh5d4io	415	12	colonization	colonization	NN
cord-296585-yfh5d4io	415	13	to	to	TO
cord-296585-yfh5d4io	415	14	avoid	avoid	VB
cord-296585-yfh5d4io	415	15	immune	immune	JJ
cord-296585-yfh5d4io	415	16	exclusion	exclusion	NN
cord-296585-yfh5d4io	415	17	by	by	IN
cord-296585-yfh5d4io	415	18	sIgA	sIgA	NNS
cord-296585-yfh5d4io	415	19	(	(	-LRB-
cord-296585-yfh5d4io	415	20	226	226	CD
cord-296585-yfh5d4io	415	21	,	,	,
cord-296585-yfh5d4io	415	22	228	228	CD
cord-296585-yfh5d4io	415	23	)	)	-RRB-
cord-296585-yfh5d4io	415	24	.	.	.
cord-296585-yfh5d4io	416	1	Reduced	reduce	VBN
cord-296585-yfh5d4io	416	2	mucosal	mucosal	JJ
cord-296585-yfh5d4io	416	3	antibodies	antibody	NNS
cord-296585-yfh5d4io	416	4	might	may	MD
cord-296585-yfh5d4io	416	5	promote	promote	VB
cord-296585-yfh5d4io	416	6	host	host	NN
cord-296585-yfh5d4io	416	7	immune	immune	JJ
cord-296585-yfh5d4io	416	8	evasion	evasion	NN
cord-296585-yfh5d4io	416	9	and	and	CC
cord-296585-yfh5d4io	416	10	resistance	resistance	NN
cord-296585-yfh5d4io	416	11	to	to	IN
cord-296585-yfh5d4io	416	12	complement	complement	VB
cord-296585-yfh5d4io	416	13	-	-	HYPH
cord-296585-yfh5d4io	416	14	mediated	mediate	VBN
cord-296585-yfh5d4io	416	15	killing	killing	NN
cord-296585-yfh5d4io	416	16	of	of	IN
cord-296585-yfh5d4io	416	17	NTHi	NTHi	NNS
cord-296585-yfh5d4io	416	18	,	,	,
cord-296585-yfh5d4io	416	19	thus	thus	RB
cord-296585-yfh5d4io	416	20	enable	enable	VB
cord-296585-yfh5d4io	416	21	persistent	persistent	JJ
cord-296585-yfh5d4io	416	22	colonization	colonization	NN
cord-296585-yfh5d4io	416	23	of	of	IN
cord-296585-yfh5d4io	416	24	NTHi	NTHi	NNS
cord-296585-yfh5d4io	416	25	in	in	IN
cord-296585-yfh5d4io	416	26	the	the	DT
cord-296585-yfh5d4io	416	27	airways	airway	NNS
cord-296585-yfh5d4io	416	28	of	of	IN
cord-296585-yfh5d4io	416	29	COPD	COPD	NNP
cord-296585-yfh5d4io	416	30	patients	patient	NNS
cord-296585-yfh5d4io	416	31	,	,	,
cord-296585-yfh5d4io	416	32	in	in	IN
cord-296585-yfh5d4io	416	33	addition	addition	NN
cord-296585-yfh5d4io	416	34	to	to	IN
cord-296585-yfh5d4io	416	35	a	a	DT
cord-296585-yfh5d4io	416	36	plethora	plethora	NN
cord-296585-yfh5d4io	416	37	of	of	IN
cord-296585-yfh5d4io	416	38	various	various	JJ
cord-296585-yfh5d4io	416	39	other	other	JJ
cord-296585-yfh5d4io	416	40	virulence	virulence	NN
cord-296585-yfh5d4io	416	41	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	416	42	(	(	-LRB-
cord-296585-yfh5d4io	416	43	4	4	CD
cord-296585-yfh5d4io	416	44	,	,	,
cord-296585-yfh5d4io	416	45	5	5	CD
cord-296585-yfh5d4io	416	46	,	,	,
cord-296585-yfh5d4io	416	47	207	207	CD
cord-296585-yfh5d4io	416	48	)	)	-RRB-
cord-296585-yfh5d4io	416	49	.	.	.
cord-296585-yfh5d4io	417	1	In	in	IN
cord-296585-yfh5d4io	417	2	a	a	DT
cord-296585-yfh5d4io	417	3	cohort	cohort	NN
cord-296585-yfh5d4io	417	4	study	study	NN
cord-296585-yfh5d4io	417	5	of	of	IN
cord-296585-yfh5d4io	417	6	stable	stable	JJ
cord-296585-yfh5d4io	417	7	COPD	COPD	NNP
cord-296585-yfh5d4io	417	8	patients	patient	NNS
cord-296585-yfh5d4io	417	9	,	,	,
cord-296585-yfh5d4io	417	10	augmented	augment	VBN
cord-296585-yfh5d4io	417	11	airway	airway	JJ
cord-296585-yfh5d4io	417	12	inflammation	inflammation	NN
cord-296585-yfh5d4io	417	13	and	and	CC
cord-296585-yfh5d4io	417	14	plasma	plasma	NN
cord-296585-yfh5d4io	417	15	fibrinogen	fibrinogen	NN
cord-296585-yfh5d4io	417	16	,	,	,
cord-296585-yfh5d4io	417	17	but	but	CC
cord-296585-yfh5d4io	417	18	not	not	RB
cord-296585-yfh5d4io	417	19	systemic	systemic	JJ
cord-296585-yfh5d4io	417	20	inflammation	inflammation	NN
cord-296585-yfh5d4io	417	21	,	,	,
cord-296585-yfh5d4io	417	22	were	be	VBD
cord-296585-yfh5d4io	417	23	found	find	VBN
cord-296585-yfh5d4io	417	24	to	to	TO
cord-296585-yfh5d4io	417	25	be	be	VB
cord-296585-yfh5d4io	417	26	constantly	constantly	RB
cord-296585-yfh5d4io	417	27	correlated	correlate	VBN
cord-296585-yfh5d4io	417	28	with	with	IN
cord-296585-yfh5d4io	417	29	the	the	DT
cord-296585-yfh5d4io	417	30	increased	increase	VBN
cord-296585-yfh5d4io	417	31	bacterial	bacterial	JJ
cord-296585-yfh5d4io	417	32	load	load	NN
cord-296585-yfh5d4io	417	33	(	(	-LRB-
cord-296585-yfh5d4io	417	34	233	233	CD
cord-296585-yfh5d4io	417	35	)	)	-RRB-
cord-296585-yfh5d4io	417	36	.	.	.
cord-296585-yfh5d4io	418	1	Higher	high	JJR
cord-296585-yfh5d4io	418	2	numbers	number	NNS
cord-296585-yfh5d4io	418	3	of	of	IN
cord-296585-yfh5d4io	418	4	NTHi	NTHi	NNS
cord-296585-yfh5d4io	418	5	has	have	VBZ
cord-296585-yfh5d4io	418	6	a	a	DT
cord-296585-yfh5d4io	418	7	greater	great	JJR
cord-296585-yfh5d4io	418	8	impact	impact	NN
cord-296585-yfh5d4io	418	9	than	than	IN
cord-296585-yfh5d4io	418	10	S.	S.	NNP
cord-296585-yfh5d4io	418	11	pneumoniae	pneumoniae	NN
cord-296585-yfh5d4io	418	12	and	and	CC
cord-296585-yfh5d4io	418	13	M.	M.	NNP
cord-296585-yfh5d4io	418	14	catarrhalis	catarrhalis	NNP
cord-296585-yfh5d4io	418	15	in	in	IN
cord-296585-yfh5d4io	418	16	triggering	trigger	VBG
cord-296585-yfh5d4io	418	17	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	418	18	responses	response	NNS
cord-296585-yfh5d4io	418	19	as	as	IN
cord-296585-yfh5d4io	418	20	measured	measure	VBN
cord-296585-yfh5d4io	418	21	by	by	IN
cord-296585-yfh5d4io	418	22	the	the	DT
cord-296585-yfh5d4io	418	23	augmented	augment	VBN
cord-296585-yfh5d4io	418	24	levels	level	NNS
cord-296585-yfh5d4io	418	25	of	of	IN
cord-296585-yfh5d4io	418	26	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	418	27	cytokines	cytokine	NNS
cord-296585-yfh5d4io	418	28	in	in	IN
cord-296585-yfh5d4io	418	29	sputum	sputum	NN
cord-296585-yfh5d4io	418	30	including	include	VBG
cord-296585-yfh5d4io	418	31	IL-8	IL-8	NNP
cord-296585-yfh5d4io	418	32	,	,	,
cord-296585-yfh5d4io	418	33	MPO	MPO	NNP
cord-296585-yfh5d4io	418	34	,	,	,
cord-296585-yfh5d4io	418	35	and	and	CC
cord-296585-yfh5d4io	418	36	1L-1β	1l-1β	CD
cord-296585-yfh5d4io	418	37	.	.	.
cord-296585-yfh5d4io	419	1	The	the	DT
cord-296585-yfh5d4io	419	2	increased	increased	JJ
cord-296585-yfh5d4io	419	3	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	419	4	response	response	NN
cord-296585-yfh5d4io	419	5	in	in	IN
cord-296585-yfh5d4io	419	6	affected	affected	JJ
cord-296585-yfh5d4io	419	7	patients	patient	NNS
cord-296585-yfh5d4io	419	8	is	be	VBZ
cord-296585-yfh5d4io	419	9	potentially	potentially	RB
cord-296585-yfh5d4io	419	10	attributed	attribute	VBN
cord-296585-yfh5d4io	419	11	to	to	IN
cord-296585-yfh5d4io	419	12	the	the	DT
cord-296585-yfh5d4io	419	13	persistent	persistent	JJ
cord-296585-yfh5d4io	419	14	colonization	colonization	NN
cord-296585-yfh5d4io	419	15	of	of	IN
cord-296585-yfh5d4io	419	16	NTHi	NTHi	NNS
cord-296585-yfh5d4io	419	17	in	in	IN
cord-296585-yfh5d4io	419	18	the	the	DT
cord-296585-yfh5d4io	419	19	lower	low	JJR
cord-296585-yfh5d4io	419	20	airway	airway	NN
cord-296585-yfh5d4io	419	21	(	(	-LRB-
cord-296585-yfh5d4io	419	22	207	207	CD
cord-296585-yfh5d4io	419	23	,	,	,
cord-296585-yfh5d4io	419	24	233	233	CD
cord-296585-yfh5d4io	419	25	)	)	-RRB-
cord-296585-yfh5d4io	419	26	.	.	.
cord-296585-yfh5d4io	420	1	The	the	DT
cord-296585-yfh5d4io	420	2	compromised	compromised	JJ
cord-296585-yfh5d4io	420	3	innate	innate	JJ
cord-296585-yfh5d4io	420	4	immune	immune	JJ
cord-296585-yfh5d4io	420	5	response	response	NN
cord-296585-yfh5d4io	420	6	in	in	IN
cord-296585-yfh5d4io	420	7	COPD	COPD	NNP
cord-296585-yfh5d4io	420	8	,	,	,
cord-296585-yfh5d4io	420	9	particularly	particularly	RB
cord-296585-yfh5d4io	420	10	the	the	DT
cord-296585-yfh5d4io	420	11	decreased	decrease	VBN
cord-296585-yfh5d4io	420	12	microbicidal	microbicidal	JJ
cord-296585-yfh5d4io	420	13	activity	activity	NN
cord-296585-yfh5d4io	420	14	,	,	,
cord-296585-yfh5d4io	420	15	has	have	VBZ
cord-296585-yfh5d4io	420	16	been	be	VBN
cord-296585-yfh5d4io	420	17	regarded	regard	VBN
cord-296585-yfh5d4io	420	18	as	as	IN
cord-296585-yfh5d4io	420	19	one	one	CD
cord-296585-yfh5d4io	420	20	of	of	IN
cord-296585-yfh5d4io	420	21	the	the	DT
cord-296585-yfh5d4io	420	22	culprits	culprit	NNS
cord-296585-yfh5d4io	420	23	for	for	IN
cord-296585-yfh5d4io	420	24	persistent	persistent	JJ
cord-296585-yfh5d4io	420	25	airway	airway	NN
cord-296585-yfh5d4io	420	26	colonization	colonization	NN
cord-296585-yfh5d4io	420	27	by	by	IN
cord-296585-yfh5d4io	420	28	NTHi	NTHi	NNS
cord-296585-yfh5d4io	420	29	,	,	,
cord-296585-yfh5d4io	420	30	and	and	CC
cord-296585-yfh5d4io	420	31	is	be	VBZ
cord-296585-yfh5d4io	420	32	highly	highly	RB
cord-296585-yfh5d4io	420	33	associated	associate	VBN
cord-296585-yfh5d4io	420	34	with	with	IN
cord-296585-yfh5d4io	420	35	COPD	COPD	NNP
cord-296585-yfh5d4io	420	36	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	420	37	(	(	-LRB-
cord-296585-yfh5d4io	420	38	Figure	figure	NN
cord-296585-yfh5d4io	420	39	2	2	CD
cord-296585-yfh5d4io	420	40	)	)	-RRB-
cord-296585-yfh5d4io	420	41	.	.	.
cord-296585-yfh5d4io	421	1	Whilst	whilst	IN
cord-296585-yfh5d4io	421	2	the	the	DT
cord-296585-yfh5d4io	421	3	role	role	NN
cord-296585-yfh5d4io	421	4	of	of	IN
cord-296585-yfh5d4io	421	5	macrophage	macrophage	NN
cord-296585-yfh5d4io	421	6	extracellular	extracellular	JJ
cord-296585-yfh5d4io	421	7	traps	trap	NNS
cord-296585-yfh5d4io	421	8	(	(	-LRB-
cord-296585-yfh5d4io	421	9	MET	MET	NNP
cord-296585-yfh5d4io	421	10	)	)	-RRB-
cord-296585-yfh5d4io	421	11	for	for	IN
cord-296585-yfh5d4io	421	12	killing	killing	NN
cord-296585-yfh5d4io	421	13	of	of	IN
cord-296585-yfh5d4io	421	14	NTHi	NTHi	NNS
cord-296585-yfh5d4io	421	15	remains	remain	VBZ
cord-296585-yfh5d4io	421	16	unknown	unknown	JJ
cord-296585-yfh5d4io	421	17	,	,	,
cord-296585-yfh5d4io	421	18	it	-PRON-	PRP
cord-296585-yfh5d4io	421	19	has	have	VBZ
cord-296585-yfh5d4io	421	20	been	be	VBN
cord-296585-yfh5d4io	421	21	reported	report	VBN
cord-296585-yfh5d4io	421	22	that	that	IN
cord-296585-yfh5d4io	421	23	blood	blood	NN
cord-296585-yfh5d4io	421	24	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	421	25	and	and	CC
cord-296585-yfh5d4io	421	26	NET	net	NN
cord-296585-yfh5d4io	421	27	from	from	IN
cord-296585-yfh5d4io	421	28	COPD	COPD	NNP
cord-296585-yfh5d4io	421	29	patients	patient	NNS
cord-296585-yfh5d4io	421	30	are	be	VBP
cord-296585-yfh5d4io	421	31	defective	defective	JJ
cord-296585-yfh5d4io	421	32	in	in	IN
cord-296585-yfh5d4io	421	33	the	the	DT
cord-296585-yfh5d4io	421	34	killing	killing	NN
cord-296585-yfh5d4io	421	35	of	of	IN
cord-296585-yfh5d4io	421	36	planktonic	planktonic	JJ
cord-296585-yfh5d4io	421	37	or	or	CC
cord-296585-yfh5d4io	421	38	biofilm	biofilm	NN
cord-296585-yfh5d4io	421	39	/	/	SYM
cord-296585-yfh5d4io	421	40	NET	net	NN
cord-296585-yfh5d4io	421	41	-	-	HYPH
cord-296585-yfh5d4io	421	42	entrapped	entrap	VBN
cord-296585-yfh5d4io	421	43	NTHi	NTHi	NNS
cord-296585-yfh5d4io	421	44	,	,	,
cord-296585-yfh5d4io	421	45	respectively	respectively	RB
cord-296585-yfh5d4io	421	46	(	(	-LRB-
cord-296585-yfh5d4io	421	47	263	263	CD
cord-296585-yfh5d4io	421	48	,	,	,
cord-296585-yfh5d4io	421	49	264	264	CD
cord-296585-yfh5d4io	421	50	,	,	,
cord-296585-yfh5d4io	421	51	290	290	CD
cord-296585-yfh5d4io	421	52	)	)	-RRB-
cord-296585-yfh5d4io	421	53	.	.	.
cord-296585-yfh5d4io	422	1	A	a	DT
cord-296585-yfh5d4io	422	2	series	series	NN
cord-296585-yfh5d4io	422	3	of	of	IN
cord-296585-yfh5d4io	422	4	studies	study	NNS
cord-296585-yfh5d4io	422	5	by	by	IN
cord-296585-yfh5d4io	422	6	Berenson	Berenson	NNP
cord-296585-yfh5d4io	422	7	et	et	NNP
cord-296585-yfh5d4io	422	8	al	al	NNP
cord-296585-yfh5d4io	422	9	.	.	NNP
cord-296585-yfh5d4io	422	10	revealed	reveal	VBD
cord-296585-yfh5d4io	422	11	that	that	IN
cord-296585-yfh5d4io	422	12	alveolar	alveolar	JJ
cord-296585-yfh5d4io	422	13	macrophages	macrophage	NNS
cord-296585-yfh5d4io	422	14	derived	derive	VBN
cord-296585-yfh5d4io	422	15	from	from	IN
cord-296585-yfh5d4io	422	16	COPD	COPD	NNP
cord-296585-yfh5d4io	422	17	patients	patient	NNS
cord-296585-yfh5d4io	422	18	are	be	VBP
cord-296585-yfh5d4io	422	19	basically	basically	RB
cord-296585-yfh5d4io	422	20	dysfunctional	dysfunctional	JJ
cord-296585-yfh5d4io	422	21	in	in	IN
cord-296585-yfh5d4io	422	22	eradication	eradication	NN
cord-296585-yfh5d4io	422	23	of	of	IN
cord-296585-yfh5d4io	422	24	NTHi	NTHi	NNS
cord-296585-yfh5d4io	422	25	(	(	-LRB-
cord-296585-yfh5d4io	422	26	177	177	CD
cord-296585-yfh5d4io	422	27	,	,	,
cord-296585-yfh5d4io	422	28	(	(	-LRB-
cord-296585-yfh5d4io	422	29	291	291	CD
cord-296585-yfh5d4io	422	30	)	)	-RRB-
cord-296585-yfh5d4io	422	31	(	(	-LRB-
cord-296585-yfh5d4io	422	32	292	292	CD
cord-296585-yfh5d4io	422	33	)	)	-RRB-
cord-296585-yfh5d4io	422	34	(	(	-LRB-
cord-296585-yfh5d4io	422	35	293	293	CD
cord-296585-yfh5d4io	422	36	)	)	-RRB-
cord-296585-yfh5d4io	422	37	.	.	.
cord-296585-yfh5d4io	423	1	Intriguingly	intriguingly	RB
cord-296585-yfh5d4io	423	2	,	,	,
cord-296585-yfh5d4io	423	3	TLR2	TLR2	NNP
cord-296585-yfh5d4io	423	4	and	and	CC
cord-296585-yfh5d4io	423	5	TLR4	TLR4	NNP
cord-296585-yfh5d4io	423	6	expressed	express	VBD
cord-296585-yfh5d4io	423	7	on	on	IN
cord-296585-yfh5d4io	423	8	alveolar	alveolar	JJ
cord-296585-yfh5d4io	423	9	macrophages	macrophage	NNS
cord-296585-yfh5d4io	423	10	from	from	IN
cord-296585-yfh5d4io	423	11	COPD	COPD	NNP
cord-296585-yfh5d4io	423	12	patients	patient	NNS
cord-296585-yfh5d4io	423	13	are	be	VBP
cord-296585-yfh5d4io	423	14	intrinsically	intrinsically	RB
cord-296585-yfh5d4io	423	15	unresponsive	unresponsive	JJ
cord-296585-yfh5d4io	423	16	to	to	IN
cord-296585-yfh5d4io	423	17	the	the	DT
cord-296585-yfh5d4io	423	18	potent	potent	JJ
cord-296585-yfh5d4io	423	19	immunomodulatory	immunomodulatory	JJ
cord-296585-yfh5d4io	423	20	lipoprotein	lipoprotein	NN
cord-296585-yfh5d4io	423	21	P6	P6	NNP
cord-296585-yfh5d4io	423	22	and	and	CC
cord-296585-yfh5d4io	423	23	LOS	LOS	NNP
cord-296585-yfh5d4io	423	24	,	,	,
cord-296585-yfh5d4io	423	25	respectively	respectively	RB
cord-296585-yfh5d4io	423	26	.	.	.
cord-296585-yfh5d4io	424	1	This	this	DT
cord-296585-yfh5d4io	424	2	causes	cause	NNS
cord-296585-yfh5d4io	424	3	decreased	decrease	VBD
cord-296585-yfh5d4io	424	4	LOS	LOS	NNP
cord-296585-yfh5d4io	424	5	/	/	SYM
cord-296585-yfh5d4io	424	6	P6-induced	p6-induce	VBN
cord-296585-yfh5d4io	424	7	expression	expression	NN
cord-296585-yfh5d4io	424	8	of	of	IN
cord-296585-yfh5d4io	424	9	TLRs	tlr	NNS
cord-296585-yfh5d4io	424	10	,	,	,
cord-296585-yfh5d4io	424	11	reduced	reduce	VBN
cord-296585-yfh5d4io	424	12	NF	nf	NN
cord-296585-yfh5d4io	424	13	-	-	HYPH
cord-296585-yfh5d4io	424	14	κB	κb	CD
cord-296585-yfh5d4io	424	15	nuclear	nuclear	JJ
cord-296585-yfh5d4io	424	16	activation	activation	NN
cord-296585-yfh5d4io	424	17	and	and	CC
cord-296585-yfh5d4io	424	18	consequently	consequently	RB
cord-296585-yfh5d4io	424	19	diminished	diminish	VBD
cord-296585-yfh5d4io	425	1	IL-8	IL-8	NNP
cord-296585-yfh5d4io	425	2	,	,	,
cord-296585-yfh5d4io	425	3	TNF	TNF	NNP
cord-296585-yfh5d4io	425	4	-	-	HYPH
cord-296585-yfh5d4io	425	5	α	α	NNP
cord-296585-yfh5d4io	425	6	,	,	,
cord-296585-yfh5d4io	425	7	and	and	CC
cord-296585-yfh5d4io	425	8	IL-1β	il-1β	DT
cord-296585-yfh5d4io	425	9	responses	response	NNS
cord-296585-yfh5d4io	425	10	by	by	IN
cord-296585-yfh5d4io	425	11	alveolar	alveolar	JJ
cord-296585-yfh5d4io	425	12	macrophages	macrophage	NNS
cord-296585-yfh5d4io	425	13	from	from	IN
cord-296585-yfh5d4io	425	14	COPD	COPD	NNP
cord-296585-yfh5d4io	425	15	patients	patient	NNS
cord-296585-yfh5d4io	425	16	.	.	.
cord-296585-yfh5d4io	426	1	The	the	DT
cord-296585-yfh5d4io	426	2	compromised	compromised	JJ
cord-296585-yfh5d4io	426	3	TLR	TLR	NNP
cord-296585-yfh5d4io	426	4	expression	expression	NN
cord-296585-yfh5d4io	426	5	and	and	CC
cord-296585-yfh5d4io	426	6	signaling	signal	VBG
cord-296585-yfh5d4io	426	7	potentially	potentially	RB
cord-296585-yfh5d4io	426	8	contribute	contribute	VBP
cord-296585-yfh5d4io	426	9	to	to	IN
cord-296585-yfh5d4io	426	10	the	the	DT
cord-296585-yfh5d4io	426	11	defective	defective	JJ
cord-296585-yfh5d4io	426	12	complement	complement	NN
cord-296585-yfh5d4io	426	13	-	-	HYPH
cord-296585-yfh5d4io	426	14	dependent	dependent	JJ
cord-296585-yfh5d4io	426	15	and	and	CC
cord-296585-yfh5d4io	426	16	independent	independent	JJ
cord-296585-yfh5d4io	426	17	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	426	18	of	of	IN
cord-296585-yfh5d4io	426	19	NTHi	NTHi	NNS
cord-296585-yfh5d4io	426	20	.	.	.
cord-296585-yfh5d4io	427	1	The	the	DT
cord-296585-yfh5d4io	427	2	defective	defective	JJ
cord-296585-yfh5d4io	427	3	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	427	4	is	be	VBZ
cord-296585-yfh5d4io	427	5	greater	great	JJR
cord-296585-yfh5d4io	427	6	for	for	IN
cord-296585-yfh5d4io	427	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	427	8	than	than	IN
cord-296585-yfh5d4io	427	9	for	for	IN
cord-296585-yfh5d4io	427	10	M.	M.	NNP
cord-296585-yfh5d4io	427	11	catarrhalis	catarrhalis	NNP
cord-296585-yfh5d4io	427	12	,	,	,
cord-296585-yfh5d4io	427	13	and	and	CC
cord-296585-yfh5d4io	427	14	correlates	correlate	VBZ
cord-296585-yfh5d4io	427	15	with	with	IN
cord-296585-yfh5d4io	427	16	disease	disease	NN
cord-296585-yfh5d4io	427	17	severity	severity	NN
cord-296585-yfh5d4io	427	18	.	.	.
cord-296585-yfh5d4io	428	1	Interestingly	interestingly	RB
cord-296585-yfh5d4io	428	2	,	,	,
cord-296585-yfh5d4io	428	3	the	the	DT
cord-296585-yfh5d4io	428	4	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	428	5	disability	disability	NN
cord-296585-yfh5d4io	428	6	was	be	VBD
cord-296585-yfh5d4io	428	7	not	not	RB
cord-296585-yfh5d4io	428	8	detected	detect	VBN
cord-296585-yfh5d4io	428	9	in	in	IN
cord-296585-yfh5d4io	428	10	monocyte	monocyte	NNP
cord-296585-yfh5d4io	428	11	-	-	HYPH
cord-296585-yfh5d4io	428	12	derived	derive	VBN
cord-296585-yfh5d4io	428	13	macrophages	macrophage	NNS
cord-296585-yfh5d4io	428	14	in	in	IN
cord-296585-yfh5d4io	428	15	COPD	COPD	NNP
cord-296585-yfh5d4io	428	16	.	.	.
cord-296585-yfh5d4io	429	1	In	in	IN
cord-296585-yfh5d4io	429	2	contrast	contrast	NN
cord-296585-yfh5d4io	429	3	,	,	,
cord-296585-yfh5d4io	429	4	however	however	RB
cord-296585-yfh5d4io	429	5	,	,	,
cord-296585-yfh5d4io	429	6	Taylor	Taylor	NNP
cord-296585-yfh5d4io	429	7	et	et	NNP
cord-296585-yfh5d4io	429	8	al	al	NNP
cord-296585-yfh5d4io	429	9	.	.	NNP
cord-296585-yfh5d4io	429	10	reported	report	VBD
cord-296585-yfh5d4io	429	11	that	that	IN
cord-296585-yfh5d4io	429	12	monocyte	monocyte	NNP
cord-296585-yfh5d4io	429	13	-	-	HYPH
cord-296585-yfh5d4io	429	14	derived	derive	VBN
cord-296585-yfh5d4io	429	15	macrophages	macrophage	NNS
cord-296585-yfh5d4io	429	16	from	from	IN
cord-296585-yfh5d4io	429	17	COPD	COPD	NNP
cord-296585-yfh5d4io	429	18	patients	patient	NNS
cord-296585-yfh5d4io	429	19	are	be	VBP
cord-296585-yfh5d4io	429	20	also	also	RB
cord-296585-yfh5d4io	429	21	defective	defective	JJ
cord-296585-yfh5d4io	429	22	in	in	IN
cord-296585-yfh5d4io	429	23	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	429	24	of	of	IN
cord-296585-yfh5d4io	429	25	NTHi	NTHi	NNS
cord-296585-yfh5d4io	429	26	and	and	CC
cord-296585-yfh5d4io	429	27	S.	S.	NNP
cord-296585-yfh5d4io	429	28	pneumoniae	pneumoniae	NN
cord-296585-yfh5d4io	429	29	.	.	.
cord-296585-yfh5d4io	430	1	The	the	DT
cord-296585-yfh5d4io	430	2	author	author	NN
cord-296585-yfh5d4io	430	3	also	also	RB
cord-296585-yfh5d4io	430	4	suggested	suggest	VBD
cord-296585-yfh5d4io	430	5	that	that	IN
cord-296585-yfh5d4io	430	6	the	the	DT
cord-296585-yfh5d4io	430	7	defective	defective	JJ
cord-296585-yfh5d4io	430	8	monocytederived	monocytederived	JJ
cord-296585-yfh5d4io	430	9	macrophages	macrophage	NNS
cord-296585-yfh5d4io	430	10	are	be	VBP
cord-296585-yfh5d4io	430	11	not	not	RB
cord-296585-yfh5d4io	430	12	attributed	attribute	VBN
cord-296585-yfh5d4io	430	13	to	to	IN
cord-296585-yfh5d4io	430	14	the	the	DT
cord-296585-yfh5d4io	430	15	alteration	alteration	NN
cord-296585-yfh5d4io	430	16	in	in	IN
cord-296585-yfh5d4io	430	17	cell	cell	NN
cord-296585-yfh5d4io	430	18	surface	surface	NN
cord-296585-yfh5d4io	430	19	TLR2	TLR2	NNP
cord-296585-yfh5d4io	430	20	or	or	CC
cord-296585-yfh5d4io	430	21	TLR4	TLR4	NNP
cord-296585-yfh5d4io	430	22	expression	expression	NN
cord-296585-yfh5d4io	430	23	,	,	,
cord-296585-yfh5d4io	430	24	macrophage	macrophage	NN
cord-296585-yfh5d4io	430	25	receptor	receptor	NN
cord-296585-yfh5d4io	430	26	with	with	IN
cord-296585-yfh5d4io	430	27	collagenous	collagenous	JJ
cord-296585-yfh5d4io	430	28	structure	structure	NN
cord-296585-yfh5d4io	430	29	(	(	-LRB-
cord-296585-yfh5d4io	430	30	MARCO	MARCO	NNP
cord-296585-yfh5d4io	430	31	)	)	-RRB-
cord-296585-yfh5d4io	430	32	,	,	.
cord-296585-yfh5d4io	431	1	CD163	CD163	NNP
cord-296585-yfh5d4io	431	2	,	,	,
cord-296585-yfh5d4io	431	3	CD36	CD36	NNP
cord-296585-yfh5d4io	431	4	or	or	CC
cord-296585-yfh5d4io	431	5	the	the	DT
cord-296585-yfh5d4io	431	6	mannose	mannose	NN
cord-296585-yfh5d4io	431	7	receptor	receptor	NN
cord-296585-yfh5d4io	431	8	(	(	-LRB-
cord-296585-yfh5d4io	431	9	178	178	CD
cord-296585-yfh5d4io	431	10	)	)	-RRB-
cord-296585-yfh5d4io	431	11	.	.	.
cord-296585-yfh5d4io	432	1	The	the	DT
cord-296585-yfh5d4io	432	2	unresponsive	unresponsive	JJ
cord-296585-yfh5d4io	432	3	TLR2	TLR2	NNP
cord-296585-yfh5d4io	432	4	and	and	CC
cord-296585-yfh5d4io	432	5	TLR4	TLR4	NNP
cord-296585-yfh5d4io	432	6	in	in	IN
cord-296585-yfh5d4io	432	7	COPD	COPD	NNP
cord-296585-yfh5d4io	432	8	alveolar	alveolar	NN
cord-296585-yfh5d4io	432	9	macrophages	macrophage	NNS
cord-296585-yfh5d4io	432	10	to	to	IN
cord-296585-yfh5d4io	432	11	NTHi	NTHi	NNP
cord-296585-yfh5d4io	432	12	lipoprotein	lipoprotein	NN
cord-296585-yfh5d4io	432	13	and	and	CC
cord-296585-yfh5d4io	432	14	LOS	LOS	NNP
cord-296585-yfh5d4io	432	15	might	may	MD
cord-296585-yfh5d4io	432	16	be	be	VB
cord-296585-yfh5d4io	432	17	explained	explain	VBN
cord-296585-yfh5d4io	432	18	by	by	IN
cord-296585-yfh5d4io	432	19	the	the	DT
cord-296585-yfh5d4io	432	20	recently	recently	RB
cord-296585-yfh5d4io	432	21	reported	report	VBN
cord-296585-yfh5d4io	432	22	phenomenon	phenomenon	NN
cord-296585-yfh5d4io	432	23	of	of	IN
cord-296585-yfh5d4io	432	24	TLR	TLR	NNP
cord-296585-yfh5d4io	432	25	tolerance	tolerance	NN
cord-296585-yfh5d4io	432	26	(	(	-LRB-
cord-296585-yfh5d4io	432	27	294	294	CD
cord-296585-yfh5d4io	432	28	)	)	-RRB-
cord-296585-yfh5d4io	432	29	.	.	.
cord-296585-yfh5d4io	433	1	Repetitive	repetitive	JJ
cord-296585-yfh5d4io	433	2	stimulation	stimulation	NN
cord-296585-yfh5d4io	433	3	of	of	IN
cord-296585-yfh5d4io	433	4	COPD	COPD	NNP
cord-296585-yfh5d4io	433	5	alveolar	alveolar	NN
cord-296585-yfh5d4io	433	6	macrophages	macrophage	NNS
cord-296585-yfh5d4io	433	7	with	with	IN
cord-296585-yfh5d4io	433	8	the	the	DT
cord-296585-yfh5d4io	433	9	same	same	JJ
cord-296585-yfh5d4io	433	10	TLR	TLR	NNP
cord-296585-yfh5d4io	433	11	ligands	ligand	NNS
cord-296585-yfh5d4io	433	12	,	,	,
cord-296585-yfh5d4io	433	13	Pam3CSK4	Pam3CSK4	NNP
cord-296585-yfh5d4io	433	14	and	and	CC
cord-296585-yfh5d4io	433	15	LPS	LPS	NNP
cord-296585-yfh5d4io	433	16	desensitizes	desensitize	VBZ
cord-296585-yfh5d4io	433	17	the	the	DT
cord-296585-yfh5d4io	433	18	TLR2	TLR2	NNP
cord-296585-yfh5d4io	433	19	and	and	CC
cord-296585-yfh5d4io	433	20	TLR4	TLR4	NNP
cord-296585-yfh5d4io	433	21	,	,	,
cord-296585-yfh5d4io	433	22	respectively	respectively	RB
cord-296585-yfh5d4io	433	23	,	,	,
cord-296585-yfh5d4io	433	24	and	and	CC
cord-296585-yfh5d4io	433	25	generates	generate	VBZ
cord-296585-yfh5d4io	433	26	TLR	TLR	NNP
cord-296585-yfh5d4io	433	27	tolerance	tolerance	NN
cord-296585-yfh5d4io	433	28	.	.	.
cord-296585-yfh5d4io	434	1	Moreover	moreover	RB
cord-296585-yfh5d4io	434	2	,	,	,
cord-296585-yfh5d4io	434	3	the	the	DT
cord-296585-yfh5d4io	434	4	repetitive	repetitive	JJ
cord-296585-yfh5d4io	434	5	TLR	TLR	NNP
cord-296585-yfh5d4io	434	6	stimulation	stimulation	NN
cord-296585-yfh5d4io	434	7	further	further	RB
cord-296585-yfh5d4io	434	8	reduced	reduce	VBD
cord-296585-yfh5d4io	434	9	the	the	DT
cord-296585-yfh5d4io	434	10	production	production	NN
cord-296585-yfh5d4io	434	11	of	of	IN
cord-296585-yfh5d4io	434	12	TNF	TNF	NNP
cord-296585-yfh5d4io	434	13	-	-	HYPH
cord-296585-yfh5d4io	434	14	α	α	NNP
cord-296585-yfh5d4io	434	15	,	,	,
cord-296585-yfh5d4io	434	16	CCL5	CCL5	NNP
cord-296585-yfh5d4io	434	17	,	,	,
cord-296585-yfh5d4io	434	18	and	and	CC
cord-296585-yfh5d4io	434	19	IL-10	IL-10	NNP
cord-296585-yfh5d4io	434	20	without	without	IN
cord-296585-yfh5d4io	434	21	affecting	affect	VBG
cord-296585-yfh5d4io	434	22	the	the	DT
cord-296585-yfh5d4io	434	23	constantly	constantly	RB
cord-296585-yfh5d4io	434	24	augmented	augment	VBN
cord-296585-yfh5d4io	434	25	level	level	NN
cord-296585-yfh5d4io	434	26	of	of	IN
cord-296585-yfh5d4io	434	27	IL-6	IL-6	NNP
cord-296585-yfh5d4io	434	28	and	and	CC
cord-296585-yfh5d4io	434	29	IL-8	IL-8	NNP
cord-296585-yfh5d4io	434	30	in	in	IN
cord-296585-yfh5d4io	434	31	alveolar	alveolar	JJ
cord-296585-yfh5d4io	434	32	macrophages	macrophage	NNS
cord-296585-yfh5d4io	434	33	.	.	.
cord-296585-yfh5d4io	435	1	This	this	DT
cord-296585-yfh5d4io	435	2	may	may	MD
cord-296585-yfh5d4io	435	3	provide	provide	VB
cord-296585-yfh5d4io	435	4	alternative	alternative	JJ
cord-296585-yfh5d4io	435	5	explanations	explanation	NNS
cord-296585-yfh5d4io	435	6	for	for	IN
cord-296585-yfh5d4io	435	7	diminished	diminished	JJ
cord-296585-yfh5d4io	435	8	immune	immune	JJ
cord-296585-yfh5d4io	435	9	responses	response	NNS
cord-296585-yfh5d4io	435	10	against	against	IN
cord-296585-yfh5d4io	435	11	the	the	DT
cord-296585-yfh5d4io	435	12	recurrent	recurrent	JJ
cord-296585-yfh5d4io	435	13	/	/	SYM
cord-296585-yfh5d4io	435	14	repetitive	repetitive	JJ
cord-296585-yfh5d4io	435	15	infection	infection	NN
cord-296585-yfh5d4io	435	16	by	by	IN
cord-296585-yfh5d4io	435	17	NTHi	NTHi	NNS
cord-296585-yfh5d4io	435	18	.	.	.
cord-296585-yfh5d4io	436	1	The	the	DT
cord-296585-yfh5d4io	436	2	intrinsically	intrinsically	RB
cord-296585-yfh5d4io	436	3	reduced	reduce	VBN
cord-296585-yfh5d4io	436	4	expression	expression	NN
cord-296585-yfh5d4io	436	5	of	of	IN
cord-296585-yfh5d4io	436	6	TLRs	tlr	NNS
cord-296585-yfh5d4io	436	7	in	in	IN
cord-296585-yfh5d4io	436	8	COPD	COPD	NNP
cord-296585-yfh5d4io	436	9	patients	patient	NNS
cord-296585-yfh5d4io	436	10	may	may	MD
cord-296585-yfh5d4io	436	11	also	also	RB
cord-296585-yfh5d4io	436	12	contribute	contribute	VB
cord-296585-yfh5d4io	436	13	to	to	IN
cord-296585-yfh5d4io	436	14	the	the	DT
cord-296585-yfh5d4io	436	15	impaired	impaired	JJ
cord-296585-yfh5d4io	436	16	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	436	17	immune	immune	JJ
cord-296585-yfh5d4io	436	18	response	response	NN
cord-296585-yfh5d4io	436	19	thus	thus	RB
cord-296585-yfh5d4io	436	20	facilitating	facilitate	VBG
cord-296585-yfh5d4io	436	21	NTHi	NTHi	NNP
cord-296585-yfh5d4io	436	22	persistent	persistent	JJ
cord-296585-yfh5d4io	436	23	colonization	colonization	NN
cord-296585-yfh5d4io	436	24	.	.	.
cord-296585-yfh5d4io	437	1	Expression	expression	NN
cord-296585-yfh5d4io	437	2	of	of	IN
cord-296585-yfh5d4io	437	3	TLR2	TLR2	NNP
cord-296585-yfh5d4io	437	4	or	or	CC
cord-296585-yfh5d4io	437	5	TLR4	TLR4	NNP
cord-296585-yfh5d4io	437	6	are	be	VBP
cord-296585-yfh5d4io	437	7	found	find	VBN
cord-296585-yfh5d4io	437	8	to	to	TO
cord-296585-yfh5d4io	437	9	be	be	VB
cord-296585-yfh5d4io	437	10	lower	low	JJR
cord-296585-yfh5d4io	437	11	on	on	IN
cord-296585-yfh5d4io	437	12	sputum	sputum	JJ
cord-296585-yfh5d4io	437	13	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	437	14	,	,	,
cord-296585-yfh5d4io	437	15	alveolar	alveolar	JJ
cord-296585-yfh5d4io	437	16	macrophages	macrophage	NNS
cord-296585-yfh5d4io	437	17	,	,	,
cord-296585-yfh5d4io	437	18	nasal	nasal	NN
cord-296585-yfh5d4io	437	19	epithelium	epithelium	NN
cord-296585-yfh5d4io	437	20	,	,	,
cord-296585-yfh5d4io	437	21	and	and	CC
cord-296585-yfh5d4io	437	22	T	t	NN
cord-296585-yfh5d4io	437	23	cells	cell	NNS
cord-296585-yfh5d4io	437	24	in	in	IN
cord-296585-yfh5d4io	437	25	COPD	COPD	NNP
cord-296585-yfh5d4io	437	26	patients	patient	NNS
cord-296585-yfh5d4io	437	27	despite	despite	IN
cord-296585-yfh5d4io	437	28	high	high	JJ
cord-296585-yfh5d4io	437	29	concentrations	concentration	NNS
cord-296585-yfh5d4io	437	30	of	of	IN
cord-296585-yfh5d4io	437	31	IL-8	IL-8	NNP
cord-296585-yfh5d4io	437	32	and	and	CC
cord-296585-yfh5d4io	437	33	MMP-9	MMP-9	NNP
cord-296585-yfh5d4io	437	34	(	(	-LRB-
cord-296585-yfh5d4io	437	35	295	295	CD
cord-296585-yfh5d4io	437	36	)	)	-RRB-
cord-296585-yfh5d4io	437	37	(	(	-LRB-
cord-296585-yfh5d4io	437	38	296	296	CD
cord-296585-yfh5d4io	437	39	)	)	-RRB-
cord-296585-yfh5d4io	437	40	(	(	-LRB-
cord-296585-yfh5d4io	437	41	297	297	CD
cord-296585-yfh5d4io	437	42	)	)	-RRB-
cord-296585-yfh5d4io	437	43	(	(	-LRB-
cord-296585-yfh5d4io	437	44	298	298	CD
cord-296585-yfh5d4io	437	45	)	)	-RRB-
cord-296585-yfh5d4io	437	46	.	.	.
cord-296585-yfh5d4io	438	1	The	the	DT
cord-296585-yfh5d4io	438	2	lack	lack	NN
cord-296585-yfh5d4io	438	3	of	of	IN
cord-296585-yfh5d4io	438	4	the	the	DT
cord-296585-yfh5d4io	438	5	more	more	RBR
cord-296585-yfh5d4io	438	6	protective	protective	JJ
cord-296585-yfh5d4io	438	7	Th1	th1	CD
cord-296585-yfh5d4io	438	8	/	/	SYM
cord-296585-yfh5d4io	438	9	Tc1	tc1	CD
cord-296585-yfh5d4io	438	10	immune	immune	JJ
cord-296585-yfh5d4io	438	11	response	response	NN
cord-296585-yfh5d4io	438	12	in	in	IN
cord-296585-yfh5d4io	438	13	COPD	COPD	NNP
cord-296585-yfh5d4io	438	14	patients	patient	NNS
cord-296585-yfh5d4io	438	15	against	against	IN
cord-296585-yfh5d4io	438	16	NTHi	NTHi	NNS
cord-296585-yfh5d4io	438	17	infection	infection	NN
cord-296585-yfh5d4io	438	18	might	may	MD
cord-296585-yfh5d4io	438	19	be	be	VB
cord-296585-yfh5d4io	438	20	attributed	attribute	VBN
cord-296585-yfh5d4io	438	21	to	to	IN
cord-296585-yfh5d4io	438	22	upregulated	upregulate	VBN
cord-296585-yfh5d4io	438	23	antagonists	antagonist	NNS
cord-296585-yfh5d4io	438	24	(	(	-LRB-
cord-296585-yfh5d4io	438	25	A20	A20	NNP
cord-296585-yfh5d4io	438	26	,	,	,
cord-296585-yfh5d4io	438	27	IRAK	IRAK	NNP
cord-296585-yfh5d4io	438	28	-	-	HYPH
cord-296585-yfh5d4io	438	29	M	M	NNP
cord-296585-yfh5d4io	438	30	,	,	,
cord-296585-yfh5d4io	438	31	and	and	CC
cord-296585-yfh5d4io	438	32	MyD88s	MyD88s	NNP
cord-296585-yfh5d4io	438	33	)	)	-RRB-
cord-296585-yfh5d4io	438	34	of	of	IN
cord-296585-yfh5d4io	438	35	the	the	DT
cord-296585-yfh5d4io	438	36	MyD88	MyD88	NNP
cord-296585-yfh5d4io	438	37	/	/	SYM
cord-296585-yfh5d4io	438	38	IRAK	IRAK	NNP
cord-296585-yfh5d4io	438	39	/	/	SYM
cord-296585-yfh5d4io	438	40	MAPK	MAPK	NNP
cord-296585-yfh5d4io	438	41	signaling	signal	VBG
cord-296585-yfh5d4io	438	42	pathway	pathway	NN
cord-296585-yfh5d4io	438	43	in	in	IN
cord-296585-yfh5d4io	438	44	COPD	COPD	NNP
cord-296585-yfh5d4io	438	45	T	T	NNP
cord-296585-yfh5d4io	438	46	cells	cell	NNS
cord-296585-yfh5d4io	438	47	(	(	-LRB-
cord-296585-yfh5d4io	438	48	295	295	CD
cord-296585-yfh5d4io	438	49	)	)	-RRB-
cord-296585-yfh5d4io	438	50	.	.	.
cord-296585-yfh5d4io	439	1	It	-PRON-	PRP
cord-296585-yfh5d4io	439	2	should	should	MD
cord-296585-yfh5d4io	439	3	be	be	VB
cord-296585-yfh5d4io	439	4	noted	note	VBN
cord-296585-yfh5d4io	439	5	that	that	IN
cord-296585-yfh5d4io	439	6	the	the	DT
cord-296585-yfh5d4io	439	7	MyD88	MyD88	NNP
cord-296585-yfh5d4io	439	8	/	/	SYM
cord-296585-yfh5d4io	439	9	IRAK	IRAK	NNP
cord-296585-yfh5d4io	439	10	/	/	SYM
cord-296585-yfh5d4io	439	11	MAPK	MAPK	NNP
cord-296585-yfh5d4io	439	12	pathway	pathway	NN
cord-296585-yfh5d4io	439	13	is	be	VBZ
cord-296585-yfh5d4io	439	14	required	require	VBN
cord-296585-yfh5d4io	439	15	for	for	IN
cord-296585-yfh5d4io	439	16	expression	expression	NN
cord-296585-yfh5d4io	439	17	of	of	IN
cord-296585-yfh5d4io	439	18	TLR4	TLR4	NNP
cord-296585-yfh5d4io	439	19	in	in	IN
cord-296585-yfh5d4io	439	20	Th1	th1	CD
cord-296585-yfh5d4io	439	21	,	,	,
cord-296585-yfh5d4io	439	22	whereas	whereas	IN
cord-296585-yfh5d4io	439	23	production	production	NN
cord-296585-yfh5d4io	439	24	of	of	IN
cord-296585-yfh5d4io	439	25	IFN	IFN	NNP
cord-296585-yfh5d4io	439	26	-	-	HYPH
cord-296585-yfh5d4io	439	27	γ	γ	NNP
cord-296585-yfh5d4io	439	28	in	in	IN
cord-296585-yfh5d4io	439	29	Th1	Th1	NNP
cord-296585-yfh5d4io	439	30	/	/	SYM
cord-296585-yfh5d4io	439	31	Tc1	tc1	CD
cord-296585-yfh5d4io	439	32	is	be	VBZ
cord-296585-yfh5d4io	439	33	TLR4-dependent	tlr4-dependent	NN
cord-296585-yfh5d4io	439	34	via	via	IN
cord-296585-yfh5d4io	439	35	the	the	DT
cord-296585-yfh5d4io	439	36	TLR4	TLR4	NNP
cord-296585-yfh5d4io	439	37	/	/	SYM
cord-296585-yfh5d4io	439	38	TRIF	TRIF	NNP
cord-296585-yfh5d4io	439	39	/	/	SYM
cord-296585-yfh5d4io	439	40	IKKe	IKKe	NNP
cord-296585-yfh5d4io	439	41	/	/	SYM
cord-296585-yfh5d4io	439	42	TBK1	TBK1	NNP
cord-296585-yfh5d4io	439	43	signaling	signal	VBG
cord-296585-yfh5d4io	439	44	pathway	pathway	NN
cord-296585-yfh5d4io	439	45	.	.	.
cord-296585-yfh5d4io	440	1	The	the	DT
cord-296585-yfh5d4io	440	2	antagonists	antagonist	NNS
cord-296585-yfh5d4io	440	3	prevent	prevent	VBP
cord-296585-yfh5d4io	440	4	the	the	DT
cord-296585-yfh5d4io	440	5	NTHi	NTHi	NNS
cord-296585-yfh5d4io	440	6	LOS	LOS	NNP
cord-296585-yfh5d4io	440	7	-	-	HYPH
cord-296585-yfh5d4io	440	8	induced	induce	VBN
cord-296585-yfh5d4io	440	9	TLR4	TLR4	NNP
cord-296585-yfh5d4io	440	10	expression	expression	NN
cord-296585-yfh5d4io	440	11	in	in	IN
cord-296585-yfh5d4io	440	12	Th1	th1	NN
cord-296585-yfh5d4io	440	13	and	and	CC
cord-296585-yfh5d4io	440	14	Tc1	tc1	CD
cord-296585-yfh5d4io	440	15	and	and	CC
cord-296585-yfh5d4io	440	16	thus	thus	RB
cord-296585-yfh5d4io	440	17	a	a	DT
cord-296585-yfh5d4io	440	18	reduced	reduce	VBN
cord-296585-yfh5d4io	440	19	secretion	secretion	NN
cord-296585-yfh5d4io	440	20	of	of	IN
cord-296585-yfh5d4io	440	21	IFN	IFN	NNP
cord-296585-yfh5d4io	440	22	-	-	HYPH
cord-296585-yfh5d4io	440	23	γ	γ	NNP
cord-296585-yfh5d4io	440	24	.	.	.
cord-296585-yfh5d4io	441	1	In	in	IN
cord-296585-yfh5d4io	441	2	addition	addition	NN
cord-296585-yfh5d4io	441	3	,	,	,
cord-296585-yfh5d4io	441	4	unusual	unusual	JJ
cord-296585-yfh5d4io	441	5	high	high	JJ
cord-296585-yfh5d4io	441	6	numbers	number	NNS
cord-296585-yfh5d4io	441	7	of	of	IN
cord-296585-yfh5d4io	441	8	Tregs	Tregs	NNP
cord-296585-yfh5d4io	441	9	in	in	IN
cord-296585-yfh5d4io	441	10	COPD	COPD	NNP
cord-296585-yfh5d4io	441	11	patients	patient	NNS
cord-296585-yfh5d4io	441	12	have	have	VBP
cord-296585-yfh5d4io	441	13	also	also	RB
cord-296585-yfh5d4io	441	14	contributed	contribute	VBN
cord-296585-yfh5d4io	441	15	to	to	TO
cord-296585-yfh5d4io	441	16	effector	effector	VB
cord-296585-yfh5d4io	441	17	T	T	NNP
cord-296585-yfh5d4io	441	18	cell	cell	NN
cord-296585-yfh5d4io	441	19	dysfunction	dysfunction	NN
cord-296585-yfh5d4io	441	20	or	or	CC
cord-296585-yfh5d4io	441	21	a	a	DT
cord-296585-yfh5d4io	441	22	Th2	th2	CD
cord-296585-yfh5d4io	441	23	/	/	SYM
cord-296585-yfh5d4io	441	24	Tc2	tc2	NN
cord-296585-yfh5d4io	441	25	predominant	predominant	JJ
cord-296585-yfh5d4io	441	26	immune	immune	JJ
cord-296585-yfh5d4io	441	27	response	response	NN
cord-296585-yfh5d4io	441	28	(	(	-LRB-
cord-296585-yfh5d4io	441	29	272	272	CD
cord-296585-yfh5d4io	441	30	)	)	-RRB-
cord-296585-yfh5d4io	441	31	.	.	.
cord-296585-yfh5d4io	442	1	However	however	RB
cord-296585-yfh5d4io	442	2	,	,	,
cord-296585-yfh5d4io	442	3	Freeman	Freeman	NNP
cord-296585-yfh5d4io	442	4	et	et	NNP
cord-296585-yfh5d4io	442	5	al	al	NNP
cord-296585-yfh5d4io	442	6	.	.	NNP
cord-296585-yfh5d4io	442	7	reported	report	VBD
cord-296585-yfh5d4io	442	8	that	that	IN
cord-296585-yfh5d4io	442	9	Tc	Tc	NNP
cord-296585-yfh5d4io	442	10	(	(	-LRB-
cord-296585-yfh5d4io	442	11	CD8	CD8	NNP
cord-296585-yfh5d4io	442	12	+	+	SYM
cord-296585-yfh5d4io	442	13	)	)	-RRB-
cord-296585-yfh5d4io	442	14	cells	cell	NNS
cord-296585-yfh5d4io	442	15	from	from	IN
cord-296585-yfh5d4io	442	16	COPD	COPD	NNP
cord-296585-yfh5d4io	442	17	patients	patient	NNS
cord-296585-yfh5d4io	442	18	have	have	VBP
cord-296585-yfh5d4io	442	19	increased	increase	VBN
cord-296585-yfh5d4io	442	20	expression	expression	NN
cord-296585-yfh5d4io	442	21	of	of	IN
cord-296585-yfh5d4io	442	22	TLR1	TLR1	NNP
cord-296585-yfh5d4io	442	23	,	,	,
cord-296585-yfh5d4io	442	24	TLR2	TLR2	NNP
cord-296585-yfh5d4io	442	25	,	,	,
cord-296585-yfh5d4io	442	26	TLR4	TLR4	NNP
cord-296585-yfh5d4io	442	27	,	,	,
cord-296585-yfh5d4io	442	28	TLR6	TLR6	NNP
cord-296585-yfh5d4io	442	29	,	,	,
cord-296585-yfh5d4io	442	30	and	and	CC
cord-296585-yfh5d4io	442	31	TLR2/1	tlr2/1	UH
cord-296585-yfh5d4io	442	32	as	as	RB
cord-296585-yfh5d4io	442	33	well	well	RB
cord-296585-yfh5d4io	442	34	as	as	IN
cord-296585-yfh5d4io	442	35	Tc1	Tc1	NNP
cord-296585-yfh5d4io	442	36	cytokines	cytokine	NNS
cord-296585-yfh5d4io	442	37	(	(	-LRB-
cord-296585-yfh5d4io	442	38	IFNγ	IFNγ	NNS
cord-296585-yfh5d4io	442	39	and	and	CC
cord-296585-yfh5d4io	442	40	TNF	TNF	NNP
cord-296585-yfh5d4io	442	41	-	-	HYPH
cord-296585-yfh5d4io	442	42	α	α	NNP
cord-296585-yfh5d4io	442	43	)	)	-RRB-
cord-296585-yfh5d4io	442	44	compared	compare	VBN
cord-296585-yfh5d4io	442	45	to	to	IN
cord-296585-yfh5d4io	442	46	healthy	healthy	JJ
cord-296585-yfh5d4io	442	47	individuals	individual	NNS
cord-296585-yfh5d4io	442	48	that	that	WDT
cord-296585-yfh5d4io	442	49	may	may	MD
cord-296585-yfh5d4io	442	50	imply	imply	VB
cord-296585-yfh5d4io	442	51	the	the	DT
cord-296585-yfh5d4io	442	52	auto	auto	NN
cord-296585-yfh5d4io	442	53	-	-	HYPH
cord-296585-yfh5d4io	442	54	aggressive	aggressive	JJ
cord-296585-yfh5d4io	442	55	response	response	NN
cord-296585-yfh5d4io	442	56	of	of	IN
cord-296585-yfh5d4io	442	57	lung	lung	NN
cord-296585-yfh5d4io	442	58	Tc	Tc	NNP
cord-296585-yfh5d4io	442	59	cells	cell	NNS
cord-296585-yfh5d4io	442	60	in	in	IN
cord-296585-yfh5d4io	442	61	COPD	COPD	NNP
cord-296585-yfh5d4io	442	62	lung	lung	NN
cord-296585-yfh5d4io	442	63	inflammation	inflammation	NN
cord-296585-yfh5d4io	442	64	(	(	-LRB-
cord-296585-yfh5d4io	442	65	299	299	CD
cord-296585-yfh5d4io	442	66	)	)	-RRB-
cord-296585-yfh5d4io	442	67	.	.	.
cord-296585-yfh5d4io	443	1	However	however	RB
cord-296585-yfh5d4io	443	2	,	,	,
cord-296585-yfh5d4io	443	3	the	the	DT
cord-296585-yfh5d4io	443	4	COPD	COPD	NNP
cord-296585-yfh5d4io	443	5	Tc	Tc	NNP
cord-296585-yfh5d4io	443	6	cells	cell	NNS
cord-296585-yfh5d4io	443	7	can	can	MD
cord-296585-yfh5d4io	443	8	only	only	RB
cord-296585-yfh5d4io	443	9	be	be	VB
cord-296585-yfh5d4io	443	10	stimulated	stimulate	VBN
cord-296585-yfh5d4io	443	11	by	by	IN
cord-296585-yfh5d4io	443	12	ligands	ligand	NNS
cord-296585-yfh5d4io	443	13	for	for	IN
cord-296585-yfh5d4io	443	14	TLR2/1	tlr2/1	XX
cord-296585-yfh5d4io	444	1	(	(	-LRB-
cord-296585-yfh5d4io	444	2	Pam3CSK4	Pam3CSK4	NNP
cord-296585-yfh5d4io	444	3	)	)	-RRB-
cord-296585-yfh5d4io	444	4	yet	yet	CC
cord-296585-yfh5d4io	444	5	tolerant	tolerant	JJ
cord-296585-yfh5d4io	444	6	to	to	IN
cord-296585-yfh5d4io	444	7	other	other	JJ
cord-296585-yfh5d4io	444	8	agonists	agonist	NNS
cord-296585-yfh5d4io	444	9	,	,	,
cord-296585-yfh5d4io	444	10	indicating	indicate	VBG
cord-296585-yfh5d4io	444	11	the	the	DT
cord-296585-yfh5d4io	444	12	dysfunctional	dysfunctional	JJ
cord-296585-yfh5d4io	444	13	TLRs	tlr	NNS
cord-296585-yfh5d4io	444	14	or	or	CC
cord-296585-yfh5d4io	444	15	TLR	TLR	NNP
cord-296585-yfh5d4io	444	16	tolerance	tolerance	NN
cord-296585-yfh5d4io	444	17	on	on	IN
cord-296585-yfh5d4io	444	18	T	t	NN
cord-296585-yfh5d4io	444	19	cells	cell	NNS
cord-296585-yfh5d4io	444	20	despite	despite	IN
cord-296585-yfh5d4io	444	21	their	-PRON-	PRP$
cord-296585-yfh5d4io	444	22	high	high	JJ
cord-296585-yfh5d4io	444	23	level	level	NN
cord-296585-yfh5d4io	444	24	of	of	IN
cord-296585-yfh5d4io	444	25	receptor	receptor	NN
cord-296585-yfh5d4io	444	26	expression	expression	NN
cord-296585-yfh5d4io	444	27	.	.	.
cord-296585-yfh5d4io	445	1	Inversely	inversely	RB
cord-296585-yfh5d4io	445	2	,	,	,
cord-296585-yfh5d4io	445	3	peripheral	peripheral	JJ
cord-296585-yfh5d4io	445	4	blood	blood	NN
cord-296585-yfh5d4io	445	5	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	445	6	isolated	isolate	VBN
cord-296585-yfh5d4io	445	7	from	from	IN
cord-296585-yfh5d4io	445	8	COPD	COPD	NNP
cord-296585-yfh5d4io	445	9	patients	patient	NNS
cord-296585-yfh5d4io	445	10	have	have	VBP
cord-296585-yfh5d4io	445	11	increased	increase	VBN
cord-296585-yfh5d4io	445	12	expression	expression	NN
cord-296585-yfh5d4io	445	13	of	of	IN
cord-296585-yfh5d4io	445	14	TLR2	TLR2	NNP
cord-296585-yfh5d4io	445	15	,	,	,
cord-296585-yfh5d4io	445	16	TLR4	TLR4	NNP
cord-296585-yfh5d4io	445	17	,	,	,
cord-296585-yfh5d4io	445	18	and	and	CC
cord-296585-yfh5d4io	445	19	NLRP3	nlrp3	NN
cord-296585-yfh5d4io	445	20	(	(	-LRB-
cord-296585-yfh5d4io	445	21	298	298	CD
cord-296585-yfh5d4io	445	22	,	,	,
cord-296585-yfh5d4io	445	23	300	300	CD
cord-296585-yfh5d4io	445	24	)	)	-RRB-
cord-296585-yfh5d4io	445	25	.	.	.
cord-296585-yfh5d4io	446	1	Nevertheless	nevertheless	RB
cord-296585-yfh5d4io	446	2	,	,	,
cord-296585-yfh5d4io	446	3	the	the	DT
cord-296585-yfh5d4io	446	4	increased	increase	VBN
cord-296585-yfh5d4io	446	5	TLRs	TLRs	NNP
cord-296585-yfh5d4io	446	6	expression	expression	NN
cord-296585-yfh5d4io	446	7	might	may	MD
cord-296585-yfh5d4io	446	8	not	not	RB
cord-296585-yfh5d4io	446	9	improve	improve	VB
cord-296585-yfh5d4io	446	10	the	the	DT
cord-296585-yfh5d4io	446	11	microbicidal	microbicidal	JJ
cord-296585-yfh5d4io	446	12	ability	ability	NN
cord-296585-yfh5d4io	446	13	of	of	IN
cord-296585-yfh5d4io	446	14	COPD	COPD	NNP
cord-296585-yfh5d4io	446	15	peripheral	peripheral	JJ
cord-296585-yfh5d4io	446	16	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	446	17	probably	probably	RB
cord-296585-yfh5d4io	446	18	due	due	IN
cord-296585-yfh5d4io	446	19	to	to	IN
cord-296585-yfh5d4io	446	20	the	the	DT
cord-296585-yfh5d4io	446	21	inaccurate	inaccurate	JJ
cord-296585-yfh5d4io	446	22	responses	response	NNS
cord-296585-yfh5d4io	446	23	to	to	IN
cord-296585-yfh5d4io	446	24	cytokines	cytokine	NNS
cord-296585-yfh5d4io	446	25	(	(	-LRB-
cord-296585-yfh5d4io	446	26	179	179	CD
cord-296585-yfh5d4io	446	27	)	)	-RRB-
cord-296585-yfh5d4io	446	28	.	.	.
cord-296585-yfh5d4io	447	1	In	in	IN
cord-296585-yfh5d4io	447	2	addition	addition	NN
cord-296585-yfh5d4io	447	3	,	,	,
cord-296585-yfh5d4io	447	4	certain	certain	JJ
cord-296585-yfh5d4io	447	5	types	type	NNS
cord-296585-yfh5d4io	447	6	of	of	IN
cord-296585-yfh5d4io	447	7	SNPs	SNPs	NNPS
cord-296585-yfh5d4io	447	8	(	(	-LRB-
cord-296585-yfh5d4io	447	9	SNPs	SNPs	NNP
cord-296585-yfh5d4io	447	10	)	)	-RRB-
cord-296585-yfh5d4io	447	11	in	in	IN
cord-296585-yfh5d4io	447	12	TLR2	TLR2	NNP
cord-296585-yfh5d4io	447	13	and	and	CC
cord-296585-yfh5d4io	447	14	TLR4	TLR4	NNP
cord-296585-yfh5d4io	447	15	have	have	VBP
cord-296585-yfh5d4io	447	16	also	also	RB
cord-296585-yfh5d4io	447	17	been	be	VBN
cord-296585-yfh5d4io	447	18	associated	associate	VBN
cord-296585-yfh5d4io	447	19	with	with	IN
cord-296585-yfh5d4io	447	20	decreased	decrease	VBN
cord-296585-yfh5d4io	447	21	lung	lung	NN
cord-296585-yfh5d4io	447	22	function	function	NN
cord-296585-yfh5d4io	447	23	,	,	,
cord-296585-yfh5d4io	447	24	enhanced	enhance	VBD
cord-296585-yfh5d4io	447	25	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	447	26	responses	response	NNS
cord-296585-yfh5d4io	447	27	and	and	CC
cord-296585-yfh5d4io	447	28	increased	increase	VBN
cord-296585-yfh5d4io	447	29	immune	immune	JJ
cord-296585-yfh5d4io	447	30	cell	cell	NN
cord-296585-yfh5d4io	447	31	infiltration	infiltration	NN
cord-296585-yfh5d4io	447	32	in	in	IN
cord-296585-yfh5d4io	447	33	COPD	COPD	NNP
cord-296585-yfh5d4io	447	34	(	(	-LRB-
cord-296585-yfh5d4io	447	35	301	301	CD
cord-296585-yfh5d4io	447	36	)	)	-RRB-
cord-296585-yfh5d4io	447	37	.	.	.
cord-296585-yfh5d4io	448	1	Interestingly	interestingly	RB
cord-296585-yfh5d4io	448	2	,	,	,
cord-296585-yfh5d4io	448	3	the	the	DT
cord-296585-yfh5d4io	448	4	diminished	diminish	VBN
cord-296585-yfh5d4io	448	5	IL-8	IL-8	NNP
cord-296585-yfh5d4io	448	6	responsiveness	responsiveness	NN
cord-296585-yfh5d4io	448	7	of	of	IN
cord-296585-yfh5d4io	448	8	COPD	COPD	NNP
cord-296585-yfh5d4io	448	9	alveolar	alveolar	NN
cord-296585-yfh5d4io	448	10	macrophage	macrophage	NN
cord-296585-yfh5d4io	448	11	to	to	IN
cord-296585-yfh5d4io	448	12	NTHi	NTHi	NNS
cord-296585-yfh5d4io	448	13	infection	infection	NN
cord-296585-yfh5d4io	448	14	has	have	VBZ
cord-296585-yfh5d4io	448	15	a	a	DT
cord-296585-yfh5d4io	448	16	strong	strong	JJ
cord-296585-yfh5d4io	448	17	association	association	NN
cord-296585-yfh5d4io	448	18	with	with	IN
cord-296585-yfh5d4io	448	19	the	the	DT
cord-296585-yfh5d4io	448	20	carriage	carriage	NN
cord-296585-yfh5d4io	448	21	of	of	IN
cord-296585-yfh5d4io	448	22	TLR9	TLR9	NNP
cord-296585-yfh5d4io	448	23	(	(	-LRB-
cord-296585-yfh5d4io	448	24	T1237C	t1237c	NN
cord-296585-yfh5d4io	448	25	)	)	-RRB-
cord-296585-yfh5d4io	448	26	polymorphism	polymorphism	NN
cord-296585-yfh5d4io	448	27	instead	instead	RB
cord-296585-yfh5d4io	448	28	of	of	IN
cord-296585-yfh5d4io	448	29	TLR2	TLR2	NNP
cord-296585-yfh5d4io	448	30	(	(	-LRB-
cord-296585-yfh5d4io	448	31	Arg753Gln	Arg753Gln	NNP
cord-296585-yfh5d4io	448	32	)	)	-RRB-
cord-296585-yfh5d4io	448	33	,	,	,
cord-296585-yfh5d4io	448	34	TLR4	TLR4	NNP
cord-296585-yfh5d4io	448	35	(	(	-LRB-
cord-296585-yfh5d4io	448	36	Thr399Ile	thr399ile	CD
cord-296585-yfh5d4io	448	37	;	;	:
cord-296585-yfh5d4io	448	38	Asp299Gly	Asp299Gly	NNP
cord-296585-yfh5d4io	448	39	)	)	-RRB-
cord-296585-yfh5d4io	448	40	,	,	,
cord-296585-yfh5d4io	448	41	and	and	CC
cord-296585-yfh5d4io	448	42	TLR9	TLR9	NNP
cord-296585-yfh5d4io	448	43	(	(	-LRB-
cord-296585-yfh5d4io	448	44	T1486C	T1486C	NNP
cord-296585-yfh5d4io	448	45	)	)	-RRB-
cord-296585-yfh5d4io	448	46	(	(	-LRB-
cord-296585-yfh5d4io	448	47	302	302	CD
cord-296585-yfh5d4io	448	48	)	)	-RRB-
cord-296585-yfh5d4io	448	49	.	.	.
cord-296585-yfh5d4io	449	1	The	the	DT
cord-296585-yfh5d4io	449	2	carriage	carriage	NN
cord-296585-yfh5d4io	449	3	of	of	IN
cord-296585-yfh5d4io	449	4	TLR9	TLR9	NNP
cord-296585-yfh5d4io	449	5	(	(	-LRB-
cord-296585-yfh5d4io	449	6	T1237C	t1237c	NN
cord-296585-yfh5d4io	449	7	)	)	-RRB-
cord-296585-yfh5d4io	449	8	is	be	VBZ
cord-296585-yfh5d4io	449	9	also	also	RB
cord-296585-yfh5d4io	449	10	positively	positively	RB
cord-296585-yfh5d4io	449	11	correlated	correlate	VBN
cord-296585-yfh5d4io	449	12	with	with	IN
cord-296585-yfh5d4io	449	13	diminished	diminished	JJ
cord-296585-yfh5d4io	449	14	lung	lung	NN
cord-296585-yfh5d4io	449	15	function	function	NN
cord-296585-yfh5d4io	449	16	.	.	.
cord-296585-yfh5d4io	450	1	Of	of	IN
cord-296585-yfh5d4io	450	2	note	note	NN
cord-296585-yfh5d4io	450	3	,	,	,
cord-296585-yfh5d4io	450	4	the	the	DT
cord-296585-yfh5d4io	450	5	activation	activation	NN
cord-296585-yfh5d4io	450	6	of	of	IN
cord-296585-yfh5d4io	450	7	TLR9-signaling	tlr9-signale	VBG
cord-296585-yfh5d4io	450	8	cascade	cascade	NN
cord-296585-yfh5d4io	450	9	in	in	IN
cord-296585-yfh5d4io	450	10	pro	pro	JJ
cord-296585-yfh5d4io	450	11	-	-	JJ
cord-296585-yfh5d4io	450	12	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	450	13	cytokine	cytokine	NN
cord-296585-yfh5d4io	450	14	response	response	NN
cord-296585-yfh5d4io	450	15	requires	require	VBZ
cord-296585-yfh5d4io	450	16	stimulation	stimulation	NN
cord-296585-yfh5d4io	450	17	from	from	IN
cord-296585-yfh5d4io	450	18	microbial	microbial	JJ
cord-296585-yfh5d4io	450	19	DNA	dna	NN
cord-296585-yfh5d4io	450	20	(	(	-LRB-
cord-296585-yfh5d4io	450	21	303	303	CD
cord-296585-yfh5d4io	450	22	)	)	-RRB-
cord-296585-yfh5d4io	450	23	.	.	.
cord-296585-yfh5d4io	451	1	The	the	DT
cord-296585-yfh5d4io	451	2	microbicidal	microbicidal	JJ
cord-296585-yfh5d4io	451	3	malfunction	malfunction	NN
cord-296585-yfh5d4io	451	4	in	in	IN
cord-296585-yfh5d4io	451	5	both	both	DT
cord-296585-yfh5d4io	451	6	innate	innate	JJ
cord-296585-yfh5d4io	451	7	and	and	CC
cord-296585-yfh5d4io	451	8	adaptive	adaptive	JJ
cord-296585-yfh5d4io	451	9	immune	immune	JJ
cord-296585-yfh5d4io	451	10	cells	cell	NNS
cord-296585-yfh5d4io	451	11	is	be	VBZ
cord-296585-yfh5d4io	451	12	also	also	RB
cord-296585-yfh5d4io	451	13	potentially	potentially	RB
cord-296585-yfh5d4io	451	14	linked	link	VBN
cord-296585-yfh5d4io	451	15	to	to	IN
cord-296585-yfh5d4io	451	16	the	the	DT
cord-296585-yfh5d4io	451	17	deleterious	deleterious	JJ
cord-296585-yfh5d4io	451	18	effect	effect	NN
cord-296585-yfh5d4io	451	19	of	of	IN
cord-296585-yfh5d4io	451	20	tobacco	tobacco	NN
cord-296585-yfh5d4io	451	21	smoke	smoke	NN
cord-296585-yfh5d4io	451	22	,	,	,
cord-296585-yfh5d4io	451	23	the	the	DT
cord-296585-yfh5d4io	451	24	major	major	JJ
cord-296585-yfh5d4io	451	25	risk	risk	NN
cord-296585-yfh5d4io	451	26	factor	factor	NN
cord-296585-yfh5d4io	451	27	for	for	IN
cord-296585-yfh5d4io	451	28	COPD	COPD	NNP
cord-296585-yfh5d4io	451	29	.	.	.
cord-296585-yfh5d4io	452	1	It	-PRON-	PRP
cord-296585-yfh5d4io	452	2	has	have	VBZ
cord-296585-yfh5d4io	452	3	been	be	VBN
cord-296585-yfh5d4io	452	4	reported	report	VBN
cord-296585-yfh5d4io	452	5	that	that	IN
cord-296585-yfh5d4io	452	6	,	,	,
cord-296585-yfh5d4io	452	7	exposure	exposure	NN
cord-296585-yfh5d4io	452	8	of	of	IN
cord-296585-yfh5d4io	452	9	tobacco	tobacco	NN
cord-296585-yfh5d4io	452	10	or	or	CC
cord-296585-yfh5d4io	452	11	cigarette	cigarette	NN
cord-296585-yfh5d4io	452	12	smoke	smoke	NN
cord-296585-yfh5d4io	452	13	can	can	MD
cord-296585-yfh5d4io	452	14	impair	impair	VB
cord-296585-yfh5d4io	452	15	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	452	16	/	/	SYM
cord-296585-yfh5d4io	452	17	engulfment	engulfment	NN
cord-296585-yfh5d4io	452	18	of	of	IN
cord-296585-yfh5d4io	452	19	NTHi	NTHi	NNS
cord-296585-yfh5d4io	452	20	by	by	IN
cord-296585-yfh5d4io	452	21	alveolar	alveolar	JJ
cord-296585-yfh5d4io	452	22	macrophages	macrophage	NNS
cord-296585-yfh5d4io	452	23	isolated	isolate	VBN
cord-296585-yfh5d4io	452	24	from	from	IN
cord-296585-yfh5d4io	452	25	COPD	COPD	NNP
cord-296585-yfh5d4io	452	26	patients	patient	NNS
cord-296585-yfh5d4io	452	27	(	(	-LRB-
cord-296585-yfh5d4io	452	28	256	256	CD
cord-296585-yfh5d4io	452	29	,	,	,
cord-296585-yfh5d4io	452	30	304	304	CD
cord-296585-yfh5d4io	452	31	)	)	-RRB-
cord-296585-yfh5d4io	452	32	.	.	.
cord-296585-yfh5d4io	453	1	Moreover	moreover	RB
cord-296585-yfh5d4io	453	2	,	,	,
cord-296585-yfh5d4io	453	3	the	the	DT
cord-296585-yfh5d4io	453	4	chemical	chemical	JJ
cord-296585-yfh5d4io	453	5	exposure	exposure	NN
cord-296585-yfh5d4io	453	6	also	also	RB
cord-296585-yfh5d4io	453	7	suppressed	suppress	VBD
cord-296585-yfh5d4io	453	8	the	the	DT
cord-296585-yfh5d4io	453	9	TLR	TLR	NNP
cord-296585-yfh5d4io	453	10	-	-	HYPH
cord-296585-yfh5d4io	453	11	induced	induce	VBN
cord-296585-yfh5d4io	453	12	TNFα	TNFα	NNP
cord-296585-yfh5d4io	453	13	,	,	,
cord-296585-yfh5d4io	453	14	IL-6	IL-6	NNP
cord-296585-yfh5d4io	453	15	,	,	,
cord-296585-yfh5d4io	453	16	and	and	CC
cord-296585-yfh5d4io	453	17	IL-10	IL-10	NNP
cord-296585-yfh5d4io	453	18	production	production	NN
cord-296585-yfh5d4io	453	19	in	in	IN
cord-296585-yfh5d4io	453	20	COPD	COPD	NNP
cord-296585-yfh5d4io	453	21	alveolar	alveolar	NN
cord-296585-yfh5d4io	453	22	macrophages	macrophage	NNS
cord-296585-yfh5d4io	453	23	that	that	WDT
cord-296585-yfh5d4io	453	24	have	have	VBP
cord-296585-yfh5d4io	453	25	been	be	VBN
cord-296585-yfh5d4io	453	26	pre	pre	VBN
cord-296585-yfh5d4io	453	27	-	-	VBN
cord-296585-yfh5d4io	453	28	stimulated	stimulate	VBN
cord-296585-yfh5d4io	453	29	with	with	IN
cord-296585-yfh5d4io	453	30	TLR2	TLR2	NNP
cord-296585-yfh5d4io	453	31	,	,	,
cord-296585-yfh5d4io	453	32	4	4	CD
cord-296585-yfh5d4io	453	33	,	,	,
cord-296585-yfh5d4io	453	34	or	or	CC
cord-296585-yfh5d4io	453	35	5	5	CD
cord-296585-yfh5d4io	453	36	ligands	ligand	NNS
cord-296585-yfh5d4io	453	37	(	(	-LRB-
cord-296585-yfh5d4io	453	38	Pam3CSK4	Pam3CSK4	NNP
cord-296585-yfh5d4io	453	39	,	,	,
cord-296585-yfh5d4io	453	40	LPS	LPS	NNP
cord-296585-yfh5d4io	453	41	,	,	,
cord-296585-yfh5d4io	453	42	or	or	CC
cord-296585-yfh5d4io	453	43	phase	phase	NN
cord-296585-yfh5d4io	453	44	I	-PRON-	PRP
cord-296585-yfh5d4io	453	45	flagellin	flagellin	VBP
cord-296585-yfh5d4io	453	46	,	,	,
cord-296585-yfh5d4io	453	47	respectively	respectively	RB
cord-296585-yfh5d4io	453	48	)	)	-RRB-
cord-296585-yfh5d4io	453	49	,	,	,
cord-296585-yfh5d4io	453	50	or	or	CC
cord-296585-yfh5d4io	453	51	whole	whole	JJ
cord-296585-yfh5d4io	453	52	NTHi	NTHi	NNS
cord-296585-yfh5d4io	453	53	bacteria	bacteria	NNS
cord-296585-yfh5d4io	453	54	(	(	-LRB-
cord-296585-yfh5d4io	453	55	305	305	CD
cord-296585-yfh5d4io	453	56	)	)	-RRB-
cord-296585-yfh5d4io	453	57	.	.	.
cord-296585-yfh5d4io	454	1	This	this	DT
cord-296585-yfh5d4io	454	2	may	may	MD
cord-296585-yfh5d4io	454	3	potentially	potentially	RB
cord-296585-yfh5d4io	454	4	delay	delay	VB
cord-296585-yfh5d4io	454	5	the	the	DT
cord-296585-yfh5d4io	454	6	macrophagedependent	macrophagedependent	NN
cord-296585-yfh5d4io	454	7	bacterial	bacterial	JJ
cord-296585-yfh5d4io	454	8	clearance	clearance	NN
cord-296585-yfh5d4io	454	9	.	.	.
cord-296585-yfh5d4io	455	1	The	the	DT
cord-296585-yfh5d4io	455	2	suppressive	suppressive	JJ
cord-296585-yfh5d4io	455	3	effect	effect	NN
cord-296585-yfh5d4io	455	4	of	of	IN
cord-296585-yfh5d4io	455	5	cigarette	cigarette	NN
cord-296585-yfh5d4io	455	6	smoke	smoke	NN
cord-296585-yfh5d4io	455	7	in	in	IN
cord-296585-yfh5d4io	455	8	macrophage	macrophage	NN
cord-296585-yfh5d4io	455	9	-	-	HYPH
cord-296585-yfh5d4io	455	10	dependent	dependent	JJ
cord-296585-yfh5d4io	455	11	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	455	12	is	be	VBZ
cord-296585-yfh5d4io	455	13	due	due	JJ
cord-296585-yfh5d4io	455	14	to	to	IN
cord-296585-yfh5d4io	455	15	the	the	DT
cord-296585-yfh5d4io	455	16	suppression	suppression	NN
cord-296585-yfh5d4io	455	17	of	of	IN
cord-296585-yfh5d4io	455	18	the	the	DT
cord-296585-yfh5d4io	455	19	PI3	PI3	NNP
cord-296585-yfh5d4io	455	20	K	K	NNP
cord-296585-yfh5d4io	455	21	signaling	signal	VBG
cord-296585-yfh5d4io	455	22	cascade	cascade	NN
cord-296585-yfh5d4io	455	23	which	which	WDT
cord-296585-yfh5d4io	455	24	is	be	VBZ
cord-296585-yfh5d4io	455	25	required	require	VBN
cord-296585-yfh5d4io	455	26	for	for	IN
cord-296585-yfh5d4io	455	27	optimal	optimal	JJ
cord-296585-yfh5d4io	455	28	phagocytic	phagocytic	JJ
cord-296585-yfh5d4io	455	29	activity	activity	NN
cord-296585-yfh5d4io	455	30	and	and	CC
cord-296585-yfh5d4io	455	31	movement	movement	NN
cord-296585-yfh5d4io	455	32	(	(	-LRB-
cord-296585-yfh5d4io	455	33	256	256	CD
cord-296585-yfh5d4io	455	34	)	)	-RRB-
cord-296585-yfh5d4io	455	35	.	.	.
cord-296585-yfh5d4io	456	1	Meanwhile	meanwhile	RB
cord-296585-yfh5d4io	456	2	,	,	,
cord-296585-yfh5d4io	456	3	the	the	DT
cord-296585-yfh5d4io	456	4	cigarette	cigarette	NN
cord-296585-yfh5d4io	456	5	smoke	smoke	NN
cord-296585-yfh5d4io	456	6	also	also	RB
cord-296585-yfh5d4io	456	7	inhibits	inhibit	VBZ
cord-296585-yfh5d4io	456	8	the	the	DT
cord-296585-yfh5d4io	456	9	activation	activation	NN
cord-296585-yfh5d4io	456	10	of	of	IN
cord-296585-yfh5d4io	456	11	the	the	DT
cord-296585-yfh5d4io	456	12	p38-ERK	p38-erk	JJ
cord-296585-yfh5d4io	456	13	signaling	signal	VBG
cord-296585-yfh5d4io	456	14	pathway	pathway	NN
cord-296585-yfh5d4io	456	15	and	and	CC
cord-296585-yfh5d4io	456	16	p65	p65	NN
cord-296585-yfh5d4io	456	17	/	/	SYM
cord-296585-yfh5d4io	456	18	NF	nf	NN
cord-296585-yfh5d4io	456	19	-	-	HYPH
cord-296585-yfh5d4io	456	20	κB	κB	NNP
cord-296585-yfh5d4io	456	21	,	,	,
cord-296585-yfh5d4io	456	22	thus	thus	RB
cord-296585-yfh5d4io	456	23	dampens	dampen	VBZ
cord-296585-yfh5d4io	456	24	the	the	DT
cord-296585-yfh5d4io	456	25	NTHi	NTHi	NNS
cord-296585-yfh5d4io	456	26	LOSinduced	losinduced	JJ
cord-296585-yfh5d4io	456	27	cytokine	cytokine	NN
cord-296585-yfh5d4io	456	28	production	production	NN
cord-296585-yfh5d4io	456	29	of	of	IN
cord-296585-yfh5d4io	456	30	COPD	COPD	NNP
cord-296585-yfh5d4io	456	31	alveolar	alveolar	NN
cord-296585-yfh5d4io	456	32	macrophages	macrophage	NNS
cord-296585-yfh5d4io	456	33	(	(	-LRB-
cord-296585-yfh5d4io	456	34	305	305	CD
cord-296585-yfh5d4io	456	35	)	)	-RRB-
cord-296585-yfh5d4io	456	36	.	.	.
cord-296585-yfh5d4io	457	1	The	the	DT
cord-296585-yfh5d4io	457	2	diminished	diminished	JJ
cord-296585-yfh5d4io	457	3	alveolar	alveolar	NN
cord-296585-yfh5d4io	457	4	macrophage	macrophage	NN
cord-296585-yfh5d4io	457	5	responsiveness	responsiveness	NN
cord-296585-yfh5d4io	457	6	could	could	MD
cord-296585-yfh5d4io	457	7	also	also	RB
cord-296585-yfh5d4io	457	8	be	be	VB
cord-296585-yfh5d4io	457	9	related	relate	VBN
cord-296585-yfh5d4io	457	10	to	to	IN
cord-296585-yfh5d4io	457	11	anticholinergic	anticholinergic	JJ
cord-296585-yfh5d4io	457	12	agents	agent	NNS
cord-296585-yfh5d4io	457	13	used	use	VBN
cord-296585-yfh5d4io	457	14	by	by	IN
cord-296585-yfh5d4io	457	15	COPD	COPD	NNP
cord-296585-yfh5d4io	457	16	patients	patient	NNS
cord-296585-yfh5d4io	457	17	that	that	IN
cord-296585-yfh5d4io	457	18	results	result	VBZ
cord-296585-yfh5d4io	457	19	in	in	IN
cord-296585-yfh5d4io	457	20	lower	low	JJR
cord-296585-yfh5d4io	457	21	concentrations	concentration	NNS
cord-296585-yfh5d4io	457	22	of	of	IN
cord-296585-yfh5d4io	457	23	NTHi	NTHi	NNS
cord-296585-yfh5d4io	457	24	-	-	HYPH
cord-296585-yfh5d4io	457	25	induced	induce	VBN
cord-296585-yfh5d4io	457	26	TNFα	TNFα	NNS
cord-296585-yfh5d4io	457	27	(	(	-LRB-
cord-296585-yfh5d4io	457	28	306	306	CD
cord-296585-yfh5d4io	457	29	)	)	-RRB-
cord-296585-yfh5d4io	457	30	.	.	.
cord-296585-yfh5d4io	458	1	Nevertheless	nevertheless	RB
cord-296585-yfh5d4io	458	2	,	,	,
cord-296585-yfh5d4io	458	3	the	the	DT
cord-296585-yfh5d4io	458	4	impaired	impaired	JJ
cord-296585-yfh5d4io	458	5	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	458	6	of	of	IN
cord-296585-yfh5d4io	458	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	458	8	by	by	IN
cord-296585-yfh5d4io	458	9	COPD	COPD	NNP
cord-296585-yfh5d4io	458	10	alveolar	alveolar	NN
cord-296585-yfh5d4io	458	11	macrophages	macrophage	NNS
cord-296585-yfh5d4io	458	12	could	could	MD
cord-296585-yfh5d4io	458	13	be	be	VB
cord-296585-yfh5d4io	458	14	improved	improve	VBN
cord-296585-yfh5d4io	458	15	in	in	IN
cord-296585-yfh5d4io	458	16	the	the	DT
cord-296585-yfh5d4io	458	17	presence	presence	NN
cord-296585-yfh5d4io	458	18	of	of	IN
cord-296585-yfh5d4io	458	19	nuclear	nuclear	JJ
cord-296585-yfh5d4io	458	20	erythroid	erythroid	NN
cord-296585-yfh5d4io	458	21	related	relate	VBN
cord-296585-yfh5d4io	458	22	factor	factor	NN
cord-296585-yfh5d4io	458	23	2	2	CD
cord-296585-yfh5d4io	458	24	and	and	CC
cord-296585-yfh5d4io	458	25	microRNA	microRNA	NNP
cord-296585-yfh5d4io	458	26	MiR-328	MiR-328	NNP
cord-296585-yfh5d4io	458	27	(	(	-LRB-
cord-296585-yfh5d4io	458	28	307	307	CD
cord-296585-yfh5d4io	458	29	,	,	,
cord-296585-yfh5d4io	458	30	308	308	CD
cord-296585-yfh5d4io	458	31	)	)	-RRB-
cord-296585-yfh5d4io	458	32	.	.	.
cord-296585-yfh5d4io	459	1	Interestingly	interestingly	RB
cord-296585-yfh5d4io	459	2	,	,	,
cord-296585-yfh5d4io	459	3	in	in	IN
cord-296585-yfh5d4io	459	4	addition	addition	NN
cord-296585-yfh5d4io	459	5	to	to	IN
cord-296585-yfh5d4io	459	6	the	the	DT
cord-296585-yfh5d4io	459	7	constant	constant	JJ
cord-296585-yfh5d4io	459	8	exacerbated	exacerbate	VBD
cord-296585-yfh5d4io	459	9	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	459	10	effect	effect	NN
cord-296585-yfh5d4io	459	11	observed	observe	VBN
cord-296585-yfh5d4io	459	12	in	in	IN
cord-296585-yfh5d4io	459	13	different	different	JJ
cord-296585-yfh5d4io	459	14	murine	murine	JJ
cord-296585-yfh5d4io	459	15	model	model	NN
cord-296585-yfh5d4io	459	16	studies	study	NNS
cord-296585-yfh5d4io	459	17	,	,	,
cord-296585-yfh5d4io	459	18	Gaschler	Gaschler	NNP
cord-296585-yfh5d4io	459	19	et	et	NNP
cord-296585-yfh5d4io	459	20	al	al	NNP
cord-296585-yfh5d4io	459	21	.	.	.
cord-296585-yfh5d4io	460	1	observed	observe	VBD
cord-296585-yfh5d4io	460	2	a	a	DT
cord-296585-yfh5d4io	460	3	rapid	rapid	JJ
cord-296585-yfh5d4io	460	4	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	460	5	clearance	clearance	NN
cord-296585-yfh5d4io	460	6	of	of	IN
cord-296585-yfh5d4io	460	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	460	8	in	in	IN
cord-296585-yfh5d4io	460	9	mice	mouse	NNS
cord-296585-yfh5d4io	460	10	upon	upon	IN
cord-296585-yfh5d4io	460	11	exposure	exposure	NN
cord-296585-yfh5d4io	460	12	to	to	IN
cord-296585-yfh5d4io	460	13	cigarette	cigarette	NN
cord-296585-yfh5d4io	460	14	smoke	smoke	NN
cord-296585-yfh5d4io	460	15	,	,	,
cord-296585-yfh5d4io	460	16	and	and	CC
cord-296585-yfh5d4io	460	17	this	this	DT
cord-296585-yfh5d4io	460	18	was	be	VBD
cord-296585-yfh5d4io	460	19	positively	positively	RB
cord-296585-yfh5d4io	460	20	correlated	correlate	VBN
cord-296585-yfh5d4io	460	21	with	with	IN
cord-296585-yfh5d4io	460	22	an	an	DT
cord-296585-yfh5d4io	460	23	increased	increase	VBN
cord-296585-yfh5d4io	460	24	neutrophilia	neutrophilia	NN
cord-296585-yfh5d4io	460	25	in	in	IN
cord-296585-yfh5d4io	460	26	the	the	DT
cord-296585-yfh5d4io	460	27	animal	animal	NN
cord-296585-yfh5d4io	460	28	BAL	bal	NN
cord-296585-yfh5d4io	460	29	fluid	fluid	NN
cord-296585-yfh5d4io	460	30	(	(	-LRB-
cord-296585-yfh5d4io	460	31	236	236	CD
cord-296585-yfh5d4io	460	32	,	,	,
cord-296585-yfh5d4io	460	33	(	(	-LRB-
cord-296585-yfh5d4io	460	34	309	309	CD
cord-296585-yfh5d4io	460	35	)	)	-RRB-
cord-296585-yfh5d4io	460	36	(	(	-LRB-
cord-296585-yfh5d4io	460	37	310	310	CD
cord-296585-yfh5d4io	460	38	)	)	-RRB-
cord-296585-yfh5d4io	460	39	(	(	-LRB-
cord-296585-yfh5d4io	460	40	311	311	CD
cord-296585-yfh5d4io	460	41	)	)	-RRB-
cord-296585-yfh5d4io	460	42	.	.	.
cord-296585-yfh5d4io	461	1	However	however	RB
cord-296585-yfh5d4io	461	2	,	,	,
cord-296585-yfh5d4io	461	3	in	in	IN
cord-296585-yfh5d4io	461	4	other	other	JJ
cord-296585-yfh5d4io	461	5	COPD	COPD	NNP
cord-296585-yfh5d4io	461	6	animal	animal	NN
cord-296585-yfh5d4io	461	7	studies	study	NNS
cord-296585-yfh5d4io	461	8	,	,	,
cord-296585-yfh5d4io	461	9	cigarette	cigarette	NN
cord-296585-yfh5d4io	461	10	smoke	smoke	NN
cord-296585-yfh5d4io	461	11	also	also	RB
cord-296585-yfh5d4io	461	12	impaired	impair	VBD
cord-296585-yfh5d4io	461	13	the	the	DT
cord-296585-yfh5d4io	461	14	IL-22	IL-22	NNP
cord-296585-yfh5d4io	461	15	production	production	NN
cord-296585-yfh5d4io	461	16	that	that	WDT
cord-296585-yfh5d4io	461	17	has	have	VBZ
cord-296585-yfh5d4io	461	18	a	a	DT
cord-296585-yfh5d4io	461	19	potential	potential	JJ
cord-296585-yfh5d4io	461	20	anti	anti	JJ
cord-296585-yfh5d4io	461	21	-	-	JJ
cord-296585-yfh5d4io	461	22	bacterial	bacterial	JJ
cord-296585-yfh5d4io	461	23	activity	activity	NN
cord-296585-yfh5d4io	461	24	while	while	IN
cord-296585-yfh5d4io	461	25	delaying	delay	VBG
cord-296585-yfh5d4io	461	26	the	the	DT
cord-296585-yfh5d4io	461	27	airway	airway	NN
cord-296585-yfh5d4io	461	28	clearance	clearance	NN
cord-296585-yfh5d4io	461	29	of	of	IN
cord-296585-yfh5d4io	461	30	NTHi	NTHi	NNPS
cord-296585-yfh5d4io	461	31	(	(	-LRB-
cord-296585-yfh5d4io	461	32	311	311	CD
cord-296585-yfh5d4io	461	33	)	)	-RRB-
cord-296585-yfh5d4io	461	34	(	(	-LRB-
cord-296585-yfh5d4io	461	35	312	312	CD
cord-296585-yfh5d4io	461	36	)	)	-RRB-
cord-296585-yfh5d4io	461	37	(	(	-LRB-
cord-296585-yfh5d4io	461	38	313	313	CD
cord-296585-yfh5d4io	461	39	)	)	-RRB-
cord-296585-yfh5d4io	461	40	.	.	.
cord-296585-yfh5d4io	462	1	Interestingly	interestingly	RB
cord-296585-yfh5d4io	462	2	,	,	,
cord-296585-yfh5d4io	462	3	IL-22	IL-22	NNP
cord-296585-yfh5d4io	462	4	might	may	MD
cord-296585-yfh5d4io	462	5	play	play	VB
cord-296585-yfh5d4io	462	6	a	a	DT
cord-296585-yfh5d4io	462	7	protective	protective	JJ
cord-296585-yfh5d4io	462	8	role	role	NN
cord-296585-yfh5d4io	462	9	in	in	IN
cord-296585-yfh5d4io	462	10	COPD	COPD	NNP
cord-296585-yfh5d4io	462	11	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	462	12	as	as	IN
cord-296585-yfh5d4io	462	13	supplementation	supplementation	NN
cord-296585-yfh5d4io	462	14	of	of	IN
cord-296585-yfh5d4io	462	15	IL-22	IL-22	NNP
cord-296585-yfh5d4io	462	16	manages	manage	VBZ
cord-296585-yfh5d4io	462	17	to	to	TO
cord-296585-yfh5d4io	462	18	restore	restore	VB
cord-296585-yfh5d4io	462	19	the	the	DT
cord-296585-yfh5d4io	462	20	homeostasis	homeostasis	NN
cord-296585-yfh5d4io	462	21	of	of	IN
cord-296585-yfh5d4io	462	22	airway	airway	JJ
cord-296585-yfh5d4io	462	23	immune	immune	JJ
cord-296585-yfh5d4io	462	24	response	response	NN
cord-296585-yfh5d4io	462	25	and	and	CC
cord-296585-yfh5d4io	462	26	improve	improve	VB
cord-296585-yfh5d4io	462	27	NTHi	NTHi	NNS
cord-296585-yfh5d4io	462	28	clearance	clearance	NN
cord-296585-yfh5d4io	462	29	(	(	-LRB-
cord-296585-yfh5d4io	462	30	313	313	CD
cord-296585-yfh5d4io	462	31	)	)	-RRB-
cord-296585-yfh5d4io	462	32	.	.	.
cord-296585-yfh5d4io	463	1	The	the	DT
cord-296585-yfh5d4io	463	2	increased	increase	VBN
cord-296585-yfh5d4io	463	3	airway	airway	NN
cord-296585-yfh5d4io	463	4	neutrophilia	neutrophilia	NNP
cord-296585-yfh5d4io	463	5	might	may	MD
cord-296585-yfh5d4io	463	6	be	be	VB
cord-296585-yfh5d4io	463	7	due	due	JJ
cord-296585-yfh5d4io	463	8	to	to	IN
cord-296585-yfh5d4io	463	9	the	the	DT
cord-296585-yfh5d4io	463	10	enhanced	enhanced	JJ
cord-296585-yfh5d4io	463	11	production	production	NN
cord-296585-yfh5d4io	463	12	of	of	IN
cord-296585-yfh5d4io	463	13	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	463	14	IL-17	IL-17	NNP
cord-296585-yfh5d4io	463	15	triggered	trigger	VBN
cord-296585-yfh5d4io	463	16	by	by	IN
cord-296585-yfh5d4io	463	17	cigarette	cigarette	NN
cord-296585-yfh5d4io	463	18	smoke	smoke	NN
cord-296585-yfh5d4io	463	19	(	(	-LRB-
cord-296585-yfh5d4io	463	20	152	152	CD
cord-296585-yfh5d4io	463	21	,	,	,
cord-296585-yfh5d4io	463	22	236	236	CD
cord-296585-yfh5d4io	463	23	,	,	,
cord-296585-yfh5d4io	463	24	311	311	CD
cord-296585-yfh5d4io	463	25	,	,	,
cord-296585-yfh5d4io	463	26	314	314	CD
cord-296585-yfh5d4io	463	27	)	)	-RRB-
cord-296585-yfh5d4io	463	28	.	.	.
cord-296585-yfh5d4io	464	1	This	this	DT
cord-296585-yfh5d4io	464	2	may	may	MD
cord-296585-yfh5d4io	464	3	imply	imply	VB
cord-296585-yfh5d4io	464	4	the	the	DT
cord-296585-yfh5d4io	464	5	important	important	JJ
cord-296585-yfh5d4io	464	6	microbicidal	microbicidal	JJ
cord-296585-yfh5d4io	464	7	role	role	NN
cord-296585-yfh5d4io	464	8	of	of	IN
cord-296585-yfh5d4io	464	9	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	464	10	(	(	-LRB-
cord-296585-yfh5d4io	464	11	neutrophilia	neutrophilia	NNP
cord-296585-yfh5d4io	464	12	)	)	-RRB-
cord-296585-yfh5d4io	464	13	in	in	IN
cord-296585-yfh5d4io	464	14	compensating	compensate	VBG
cord-296585-yfh5d4io	464	15	the	the	DT
cord-296585-yfh5d4io	464	16	COPD	COPD	NNP
cord-296585-yfh5d4io	464	17	-	-	:
cord-296585-yfh5d4io	464	18	or	or	CC
cord-296585-yfh5d4io	464	19	cigarette	cigarette	NN
cord-296585-yfh5d4io	464	20	smoke	smoke	NN
cord-296585-yfh5d4io	464	21	-	-	HYPH
cord-296585-yfh5d4io	464	22	associated	associate	VBN
cord-296585-yfh5d4io	464	23	dysfunctional	dysfunctional	JJ
cord-296585-yfh5d4io	464	24	alveolar	alveolar	NN
cord-296585-yfh5d4io	464	25	macrophages	macrophage	NNS
cord-296585-yfh5d4io	464	26	(	(	-LRB-
cord-296585-yfh5d4io	464	27	96	96	CD
cord-296585-yfh5d4io	464	28	,	,	,
cord-296585-yfh5d4io	464	29	315	315	CD
cord-296585-yfh5d4io	464	30	)	)	-RRB-
cord-296585-yfh5d4io	464	31	.	.	.
cord-296585-yfh5d4io	465	1	However	however	RB
cord-296585-yfh5d4io	465	2	,	,	,
cord-296585-yfh5d4io	465	3	such	such	JJ
cord-296585-yfh5d4io	465	4	compensation	compensation	NN
cord-296585-yfh5d4io	465	5	may	may	MD
cord-296585-yfh5d4io	465	6	not	not	RB
cord-296585-yfh5d4io	465	7	be	be	VB
cord-296585-yfh5d4io	465	8	adequate	adequate	JJ
cord-296585-yfh5d4io	465	9	to	to	TO
cord-296585-yfh5d4io	465	10	provide	provide	VB
cord-296585-yfh5d4io	465	11	optimal	optimal	JJ
cord-296585-yfh5d4io	465	12	immune	immune	JJ
cord-296585-yfh5d4io	465	13	defense	defense	NN
cord-296585-yfh5d4io	465	14	to	to	TO
cord-296585-yfh5d4io	465	15	eradicate	eradicate	VB
cord-296585-yfh5d4io	465	16	persistent	persistent	JJ
cord-296585-yfh5d4io	465	17	NTHi	NTHi	NNS
cord-296585-yfh5d4io	465	18	lower	low	JJR
cord-296585-yfh5d4io	465	19	airway	airway	NN
cord-296585-yfh5d4io	465	20	colonization	colonization	NN
cord-296585-yfh5d4io	465	21	,	,	,
cord-296585-yfh5d4io	465	22	since	since	IN
cord-296585-yfh5d4io	465	23	the	the	DT
cord-296585-yfh5d4io	465	24	cigarette	cigarette	NN
cord-296585-yfh5d4io	465	25	smoke	smoke	NN
cord-296585-yfh5d4io	465	26	also	also	RB
cord-296585-yfh5d4io	465	27	has	have	VBZ
cord-296585-yfh5d4io	465	28	profound	profound	JJ
cord-296585-yfh5d4io	465	29	suppressive	suppressive	JJ
cord-296585-yfh5d4io	465	30	effect	effect	NN
cord-296585-yfh5d4io	465	31	on	on	IN
cord-296585-yfh5d4io	465	32	the	the	DT
cord-296585-yfh5d4io	465	33	host	host	NN
cord-296585-yfh5d4io	465	34	adaptive	adaptive	JJ
cord-296585-yfh5d4io	465	35	immunity	immunity	NN
cord-296585-yfh5d4io	465	36	,	,	,
cord-296585-yfh5d4io	465	37	thus	thus	RB
cord-296585-yfh5d4io	465	38	constantly	constantly	RB
cord-296585-yfh5d4io	465	39	risking	risk	VBG
cord-296585-yfh5d4io	465	40	the	the	DT
cord-296585-yfh5d4io	465	41	COPD	COPD	NNP
cord-296585-yfh5d4io	465	42	patients	patient	NNS
cord-296585-yfh5d4io	465	43	to	to	IN
cord-296585-yfh5d4io	465	44	episodes	episode	NNS
cord-296585-yfh5d4io	465	45	of	of	IN
cord-296585-yfh5d4io	465	46	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	465	47	and	and	CC
cord-296585-yfh5d4io	465	48	relapsed	relapse	VBN
cord-296585-yfh5d4io	465	49	infection	infection	NN
cord-296585-yfh5d4io	465	50	.	.	.
cord-296585-yfh5d4io	466	1	In	in	IN
cord-296585-yfh5d4io	466	2	adaptive	adaptive	JJ
cord-296585-yfh5d4io	466	3	immunity	immunity	NN
cord-296585-yfh5d4io	466	4	,	,	,
cord-296585-yfh5d4io	466	5	cigarette	cigarette	NN
cord-296585-yfh5d4io	466	6	smoke	smoke	NN
cord-296585-yfh5d4io	466	7	impairs	impair	VBZ
cord-296585-yfh5d4io	466	8	the	the	DT
cord-296585-yfh5d4io	466	9	antigen	antigen	NN
cord-296585-yfh5d4io	466	10	-	-	HYPH
cord-296585-yfh5d4io	466	11	specific	specific	JJ
cord-296585-yfh5d4io	466	12	B	b	NN
cord-296585-yfh5d4io	466	13	and	and	CC
cord-296585-yfh5d4io	466	14	T	t	NN
cord-296585-yfh5d4io	466	15	cells	cell	NNS
cord-296585-yfh5d4io	466	16	responses	response	NNS
cord-296585-yfh5d4io	466	17	to	to	IN
cord-296585-yfh5d4io	466	18	NTHi	NTHi	NNS
cord-296585-yfh5d4io	466	19	infection	infection	NN
cord-296585-yfh5d4io	466	20	.	.	.
cord-296585-yfh5d4io	467	1	It	-PRON-	PRP
cord-296585-yfh5d4io	467	2	suppresses	suppress	VBZ
cord-296585-yfh5d4io	467	3	the	the	DT
cord-296585-yfh5d4io	467	4	secretion	secretion	NN
cord-296585-yfh5d4io	467	5	of	of	IN
cord-296585-yfh5d4io	467	6	IFNγ	IFNγ	NNS
cord-296585-yfh5d4io	467	7	and	and	CC
cord-296585-yfh5d4io	467	8	IL-4	IL-4	NNP
cord-296585-yfh5d4io	467	9	by	by	IN
cord-296585-yfh5d4io	467	10	NTHi	NTHi	NNS
cord-296585-yfh5d4io	467	11	-	-	HYPH
cord-296585-yfh5d4io	467	12	specific	specific	JJ
cord-296585-yfh5d4io	467	13	T	t	NN
cord-296585-yfh5d4io	467	14	cells	cell	NNS
cord-296585-yfh5d4io	467	15	.	.	.
cord-296585-yfh5d4io	468	1	Antibody	antibody	NN
cord-296585-yfh5d4io	468	2	production	production	NN
cord-296585-yfh5d4io	468	3	by	by	IN
cord-296585-yfh5d4io	468	4	B	b	NN
cord-296585-yfh5d4io	468	5	cells	cell	NNS
cord-296585-yfh5d4io	468	6	has	have	VBZ
cord-296585-yfh5d4io	468	7	also	also	RB
cord-296585-yfh5d4io	468	8	been	be	VBN
cord-296585-yfh5d4io	468	9	attenuated	attenuate	VBN
cord-296585-yfh5d4io	468	10	,	,	,
cord-296585-yfh5d4io	468	11	with	with	IN
cord-296585-yfh5d4io	468	12	lower	low	JJR
cord-296585-yfh5d4io	468	13	levels	level	NNS
cord-296585-yfh5d4io	468	14	of	of	IN
cord-296585-yfh5d4io	468	15	specific	specific	JJ
cord-296585-yfh5d4io	468	16	anti	anti	JJ
cord-296585-yfh5d4io	468	17	-	-	JJ
cord-296585-yfh5d4io	468	18	P6	p6	JJ
cord-296585-yfh5d4io	468	19	antibodies	antibody	NNS
cord-296585-yfh5d4io	468	20	and	and	CC
cord-296585-yfh5d4io	468	21	compromised	compromise	VBN
cord-296585-yfh5d4io	468	22	IgG1	igg1	PRP
cord-296585-yfh5d4io	468	23	,	,	,
cord-296585-yfh5d4io	468	24	IgG2a	IgG2a	NNP
cord-296585-yfh5d4io	468	25	,	,	,
cord-296585-yfh5d4io	468	26	and	and	CC
cord-296585-yfh5d4io	468	27	IgA	IgA	NNP
cord-296585-yfh5d4io	468	28	class	class	NN
cord-296585-yfh5d4io	468	29	switching	switching	NN
cord-296585-yfh5d4io	468	30	(	(	-LRB-
cord-296585-yfh5d4io	468	31	311	311	CD
cord-296585-yfh5d4io	468	32	,	,	,
cord-296585-yfh5d4io	468	33	312	312	CD
cord-296585-yfh5d4io	468	34	)	)	-RRB-
cord-296585-yfh5d4io	468	35	.	.	.
cord-296585-yfh5d4io	469	1	A	a	DT
cord-296585-yfh5d4io	469	2	recent	recent	JJ
cord-296585-yfh5d4io	469	3	and	and	CC
cord-296585-yfh5d4io	469	4	some	some	DT
cord-296585-yfh5d4io	469	5	previous	previous	JJ
cord-296585-yfh5d4io	469	6	cohort	cohort	NN
cord-296585-yfh5d4io	469	7	studies	study	NNS
cord-296585-yfh5d4io	469	8	revealed	reveal	VBD
cord-296585-yfh5d4io	469	9	that	that	IN
cord-296585-yfh5d4io	469	10	the	the	DT
cord-296585-yfh5d4io	469	11	level	level	NN
cord-296585-yfh5d4io	469	12	of	of	IN
cord-296585-yfh5d4io	469	13	airway	airway	NN
cord-296585-yfh5d4io	469	14	antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	469	15	cathelicidin	cathelicidin	NNP
cord-296585-yfh5d4io	469	16	(	(	-LRB-
cord-296585-yfh5d4io	469	17	hCAP18	hCAP18	NNP
cord-296585-yfh5d4io	469	18	/	/	SYM
cord-296585-yfh5d4io	469	19	LL-37	LL-37	NNP
cord-296585-yfh5d4io	469	20	)	)	-RRB-
cord-296585-yfh5d4io	469	21	in	in	IN
cord-296585-yfh5d4io	469	22	COPD	COPD	NNP
cord-296585-yfh5d4io	469	23	patients	patient	NNS
cord-296585-yfh5d4io	469	24	increase	increase	VBP
cord-296585-yfh5d4io	469	25	gradually	gradually	RB
cord-296585-yfh5d4io	469	26	from	from	IN
cord-296585-yfh5d4io	469	27	the	the	DT
cord-296585-yfh5d4io	469	28	stable	stable	JJ
cord-296585-yfh5d4io	469	29	disease	disease	NN
cord-296585-yfh5d4io	469	30	to	to	IN
cord-296585-yfh5d4io	469	31	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	469	32	states	state	NNS
cord-296585-yfh5d4io	469	33	(	(	-LRB-
cord-296585-yfh5d4io	469	34	176	176	CD
cord-296585-yfh5d4io	469	35	,	,	,
cord-296585-yfh5d4io	469	36	316	316	CD
cord-296585-yfh5d4io	469	37	)	)	-RRB-
cord-296585-yfh5d4io	469	38	.	.	.
cord-296585-yfh5d4io	470	1	Moreover	moreover	RB
cord-296585-yfh5d4io	470	2	,	,	,
cord-296585-yfh5d4io	470	3	higher	high	JJR
cord-296585-yfh5d4io	470	4	levels	level	NNS
cord-296585-yfh5d4io	470	5	of	of	IN
cord-296585-yfh5d4io	470	6	cathelicidin	cathelicidin	NNS
cord-296585-yfh5d4io	470	7	are	be	VBP
cord-296585-yfh5d4io	470	8	positively	positively	RB
cord-296585-yfh5d4io	470	9	associated	associate	VBN
cord-296585-yfh5d4io	470	10	with	with	IN
cord-296585-yfh5d4io	470	11	NTHi	nthi	JJ
cord-296585-yfh5d4io	470	12	airway	airway	NN
cord-296585-yfh5d4io	470	13	colonization	colonization	NN
cord-296585-yfh5d4io	470	14	,	,	,
cord-296585-yfh5d4io	470	15	sputum	sputum	NNP
cord-296585-yfh5d4io	470	16	neutrophilia	neutrophilia	NNP
cord-296585-yfh5d4io	470	17	,	,	,
cord-296585-yfh5d4io	470	18	and	and	CC
cord-296585-yfh5d4io	470	19	higher	high	JJR
cord-296585-yfh5d4io	470	20	concentrations	concentration	NNS
cord-296585-yfh5d4io	470	21	of	of	IN
cord-296585-yfh5d4io	470	22	IL-8	IL-8	NNP
cord-296585-yfh5d4io	470	23	,	,	,
cord-296585-yfh5d4io	470	24	particularly	particularly	RB
cord-296585-yfh5d4io	470	25	in	in	IN
cord-296585-yfh5d4io	470	26	the	the	DT
cord-296585-yfh5d4io	470	27	NTHi	NTHi	NNS
cord-296585-yfh5d4io	470	28	-	-	HYPH
cord-296585-yfh5d4io	470	29	infected	infect	VBN
cord-296585-yfh5d4io	470	30	COPD	COPD	NNP
cord-296585-yfh5d4io	470	31	patients	patient	NNS
cord-296585-yfh5d4io	470	32	.	.	.
cord-296585-yfh5d4io	471	1	Of	of	IN
cord-296585-yfh5d4io	471	2	note	note	NN
cord-296585-yfh5d4io	471	3	,	,	,
cord-296585-yfh5d4io	471	4	cathelicidin	cathelicidin	NNP
cord-296585-yfh5d4io	471	5	and	and	CC
cord-296585-yfh5d4io	471	6	other	other	JJ
cord-296585-yfh5d4io	471	7	AMPs	amp	NNS
cord-296585-yfh5d4io	471	8	play	play	VBP
cord-296585-yfh5d4io	471	9	important	important	JJ
cord-296585-yfh5d4io	471	10	roles	role	NNS
cord-296585-yfh5d4io	471	11	in	in	IN
cord-296585-yfh5d4io	471	12	the	the	DT
cord-296585-yfh5d4io	471	13	innate	innate	JJ
cord-296585-yfh5d4io	471	14	immune	immune	JJ
cord-296585-yfh5d4io	471	15	defense	defense	NN
cord-296585-yfh5d4io	471	16	against	against	IN
cord-296585-yfh5d4io	471	17	different	different	JJ
cord-296585-yfh5d4io	471	18	pathogens	pathogen	NNS
cord-296585-yfh5d4io	471	19	and	and	CC
cord-296585-yfh5d4io	471	20	persist	persist	VB
cord-296585-yfh5d4io	471	21	immunomodulatory	immunomodulatory	JJ
cord-296585-yfh5d4io	471	22	properties	property	NNS
cord-296585-yfh5d4io	471	23	(	(	-LRB-
cord-296585-yfh5d4io	471	24	317	317	CD
cord-296585-yfh5d4io	471	25	)	)	-RRB-
cord-296585-yfh5d4io	471	26	(	(	-LRB-
cord-296585-yfh5d4io	471	27	318	318	CD
cord-296585-yfh5d4io	471	28	)	)	-RRB-
cord-296585-yfh5d4io	471	29	(	(	-LRB-
cord-296585-yfh5d4io	471	30	319	319	CD
cord-296585-yfh5d4io	471	31	)	)	-RRB-
cord-296585-yfh5d4io	471	32	.	.	.
cord-296585-yfh5d4io	472	1	Ironically	ironically	RB
cord-296585-yfh5d4io	472	2	,	,	,
cord-296585-yfh5d4io	472	3	it	-PRON-	PRP
cord-296585-yfh5d4io	472	4	is	be	VBZ
cord-296585-yfh5d4io	472	5	plausible	plausible	JJ
cord-296585-yfh5d4io	472	6	that	that	IN
cord-296585-yfh5d4io	472	7	the	the	DT
cord-296585-yfh5d4io	472	8	increased	increase	VBN
cord-296585-yfh5d4io	472	9	level	level	NN
cord-296585-yfh5d4io	472	10	of	of	IN
cord-296585-yfh5d4io	472	11	cathelicidin	cathelicidin	NNS
cord-296585-yfh5d4io	472	12	could	could	MD
cord-296585-yfh5d4io	472	13	diminish	diminish	VB
cord-296585-yfh5d4io	472	14	or	or	CC
cord-296585-yfh5d4io	472	15	alter	alter	VB
cord-296585-yfh5d4io	472	16	the	the	DT
cord-296585-yfh5d4io	472	17	balance	balance	NN
cord-296585-yfh5d4io	472	18	in	in	IN
cord-296585-yfh5d4io	472	19	lung	lung	NN
cord-296585-yfh5d4io	472	20	microbiota	microbiota	NN
cord-296585-yfh5d4io	472	21	,	,	,
cord-296585-yfh5d4io	472	22	and	and	CC
cord-296585-yfh5d4io	472	23	the	the	DT
cord-296585-yfh5d4io	472	24	immune	immune	JJ
cord-296585-yfh5d4io	472	25	/	/	SYM
cord-296585-yfh5d4io	472	26	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	472	27	response	response	NN
cord-296585-yfh5d4io	472	28	.	.	.
cord-296585-yfh5d4io	473	1	This	this	DT
cord-296585-yfh5d4io	473	2	might	may	MD
cord-296585-yfh5d4io	473	3	contribute	contribute	VB
cord-296585-yfh5d4io	473	4	to	to	IN
cord-296585-yfh5d4io	473	5	the	the	DT
cord-296585-yfh5d4io	473	6	"	"	``
cord-296585-yfh5d4io	473	7	vicious	vicious	JJ
cord-296585-yfh5d4io	473	8	circle	circle	NN
cord-296585-yfh5d4io	473	9	,	,	,
cord-296585-yfh5d4io	473	10	"	"	''
cord-296585-yfh5d4io	473	11	thus	thus	RB
cord-296585-yfh5d4io	473	12	considerably	considerably	RB
cord-296585-yfh5d4io	473	13	increasing	increase	VBG
cord-296585-yfh5d4io	473	14	the	the	DT
cord-296585-yfh5d4io	473	15	risk	risk	NN
cord-296585-yfh5d4io	473	16	for	for	IN
cord-296585-yfh5d4io	473	17	NTHi	NTHi	NNS
cord-296585-yfh5d4io	473	18	infection	infection	NN
cord-296585-yfh5d4io	473	19	during	during	IN
cord-296585-yfh5d4io	473	20	COPD	COPD	NNP
cord-296585-yfh5d4io	473	21	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	473	22	(	(	-LRB-
cord-296585-yfh5d4io	473	23	214	214	CD
cord-296585-yfh5d4io	473	24	,	,	,
cord-296585-yfh5d4io	473	25	320	320	CD
cord-296585-yfh5d4io	473	26	)	)	-RRB-
cord-296585-yfh5d4io	473	27	.	.	.
cord-296585-yfh5d4io	474	1	Moreover	moreover	RB
cord-296585-yfh5d4io	474	2	,	,	,
cord-296585-yfh5d4io	474	3	the	the	DT
cord-296585-yfh5d4io	474	4	microbicidal	microbicidal	JJ
cord-296585-yfh5d4io	474	5	property	property	NN
cord-296585-yfh5d4io	474	6	of	of	IN
cord-296585-yfh5d4io	474	7	cathelicidin	cathelicidin	NNP
cord-296585-yfh5d4io	474	8	could	could	MD
cord-296585-yfh5d4io	474	9	be	be	VB
cord-296585-yfh5d4io	474	10	compromised	compromise	VBN
cord-296585-yfh5d4io	474	11	by	by	IN
cord-296585-yfh5d4io	474	12	the	the	DT
cord-296585-yfh5d4io	474	13	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	474	14	conditions	condition	NNS
cord-296585-yfh5d4io	474	15	in	in	IN
cord-296585-yfh5d4io	474	16	the	the	DT
cord-296585-yfh5d4io	474	17	airway	airway	NN
cord-296585-yfh5d4io	474	18	,	,	,
cord-296585-yfh5d4io	474	19	such	such	JJ
cord-296585-yfh5d4io	474	20	as	as	IN
cord-296585-yfh5d4io	474	21	low	low	JJ
cord-296585-yfh5d4io	474	22	pH	ph	NN
cord-296585-yfh5d4io	474	23	,	,	,
cord-296585-yfh5d4io	474	24	or	or	CC
cord-296585-yfh5d4io	474	25	the	the	DT
cord-296585-yfh5d4io	474	26	effect	effect	NN
cord-296585-yfh5d4io	474	27	of	of	IN
cord-296585-yfh5d4io	474	28	cigarettes	cigarette	NNS
cord-296585-yfh5d4io	474	29	that	that	WDT
cord-296585-yfh5d4io	474	30	causes	cause	VBZ
cord-296585-yfh5d4io	474	31	peptide	peptide	JJ
cord-296585-yfh5d4io	474	32	citrulination	citrulination	NN
cord-296585-yfh5d4io	474	33	and	and	CC
cord-296585-yfh5d4io	474	34	modification	modification	NN
cord-296585-yfh5d4io	474	35	(	(	-LRB-
cord-296585-yfh5d4io	474	36	321	321	CD
cord-296585-yfh5d4io	474	37	,	,	,
cord-296585-yfh5d4io	474	38	322	322	CD
cord-296585-yfh5d4io	474	39	)	)	-RRB-
cord-296585-yfh5d4io	474	40	.	.	.
cord-296585-yfh5d4io	475	1	Finally	finally	RB
cord-296585-yfh5d4io	475	2	,	,	,
cord-296585-yfh5d4io	475	3	expression	expression	NN
cord-296585-yfh5d4io	475	4	of	of	IN
cord-296585-yfh5d4io	475	5	AMPs	amp	NNS
cord-296585-yfh5d4io	475	6	(	(	-LRB-
cord-296585-yfh5d4io	475	7	human	human	JJ
cord-296585-yfh5d4io	475	8	beta	beta	NN
cord-296585-yfh5d4io	475	9	defensin	defensin	NNP
cord-296585-yfh5d4io	475	10	2	2	CD
cord-296585-yfh5d4io	475	11	and	and	CC
cord-296585-yfh5d4io	475	12	S100A7	S100A7	NNP
cord-296585-yfh5d4io	475	13	)	)	-RRB-
cord-296585-yfh5d4io	475	14	by	by	IN
cord-296585-yfh5d4io	475	15	COPD	COPD	NNP
cord-296585-yfh5d4io	475	16	airway	airway	NN
cord-296585-yfh5d4io	475	17	epithelium	epithelium	NN
cord-296585-yfh5d4io	475	18	in	in	IN
cord-296585-yfh5d4io	475	19	response	response	NN
cord-296585-yfh5d4io	475	20	to	to	IN
cord-296585-yfh5d4io	475	21	NTHi	NTHi	NNS
cord-296585-yfh5d4io	475	22	infection	infection	NN
cord-296585-yfh5d4io	475	23	,	,	,
cord-296585-yfh5d4io	475	24	is	be	VBZ
cord-296585-yfh5d4io	475	25	also	also	RB
cord-296585-yfh5d4io	475	26	disturbed	disturb	VBN
cord-296585-yfh5d4io	475	27	by	by	IN
cord-296585-yfh5d4io	475	28	cigarette	cigarette	NN
cord-296585-yfh5d4io	475	29	smoke	smoke	NN
cord-296585-yfh5d4io	475	30	.	.	.
cord-296585-yfh5d4io	476	1	The	the	DT
cord-296585-yfh5d4io	476	2	insulted	insult	VBN
cord-296585-yfh5d4io	476	3	airway	airway	NN
cord-296585-yfh5d4io	476	4	cells	cell	NNS
cord-296585-yfh5d4io	476	5	have	have	VBP
cord-296585-yfh5d4io	476	6	also	also	RB
cord-296585-yfh5d4io	476	7	a	a	DT
cord-296585-yfh5d4io	476	8	reduced	reduce	VBN
cord-296585-yfh5d4io	476	9	expression	expression	NN
cord-296585-yfh5d4io	476	10	of	of	IN
cord-296585-yfh5d4io	476	11	TLR4	TLR4	NNP
cord-296585-yfh5d4io	476	12	and	and	CC
cord-296585-yfh5d4io	476	13	IL-8	IL-8	NNP
cord-296585-yfh5d4io	476	14	,	,	,
cord-296585-yfh5d4io	476	15	and	and	CC
cord-296585-yfh5d4io	476	16	impaired	impaired	JJ
cord-296585-yfh5d4io	476	17	NTHi	NTHi	NNS
cord-296585-yfh5d4io	476	18	-	-	HYPH
cord-296585-yfh5d4io	476	19	induced	induce	VBN
cord-296585-yfh5d4io	476	20	NF	nf	NN
cord-296585-yfh5d4io	476	21	-	-	HYPH
cord-296585-yfh5d4io	476	22	κB	κb	CD
cord-296585-yfh5d4io	476	23	activation	activation	NN
cord-296585-yfh5d4io	476	24	(	(	-LRB-
cord-296585-yfh5d4io	476	25	175	175	CD
cord-296585-yfh5d4io	476	26	,	,	,
cord-296585-yfh5d4io	476	27	296	296	CD
cord-296585-yfh5d4io	476	28	)	)	-RRB-
cord-296585-yfh5d4io	476	29	.	.	.
cord-296585-yfh5d4io	477	1	Thus	thus	RB
cord-296585-yfh5d4io	477	2	,	,	,
cord-296585-yfh5d4io	477	3	a	a	DT
cord-296585-yfh5d4io	477	4	large	large	JJ
cord-296585-yfh5d4io	477	5	body	body	NN
cord-296585-yfh5d4io	477	6	of	of	IN
cord-296585-yfh5d4io	477	7	evidence	evidence	NN
cord-296585-yfh5d4io	477	8	exists	exist	VBZ
cord-296585-yfh5d4io	477	9	on	on	IN
cord-296585-yfh5d4io	477	10	the	the	DT
cord-296585-yfh5d4io	477	11	deleterious	deleterious	JJ
cord-296585-yfh5d4io	477	12	effects	effect	NNS
cord-296585-yfh5d4io	477	13	of	of	IN
cord-296585-yfh5d4io	477	14	tobacco	tobacco	NN
cord-296585-yfh5d4io	477	15	smoke	smoke	NN
cord-296585-yfh5d4io	477	16	.	.	.
cord-296585-yfh5d4io	478	1	Antibiotic	antibiotic	JJ
cord-296585-yfh5d4io	478	2	treatment	treatment	NN
cord-296585-yfh5d4io	478	3	of	of	IN
cord-296585-yfh5d4io	478	4	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	478	5	has	have	VBZ
cord-296585-yfh5d4io	478	6	been	be	VBN
cord-296585-yfh5d4io	478	7	shown	show	VBN
cord-296585-yfh5d4io	478	8	to	to	TO
cord-296585-yfh5d4io	478	9	significantly	significantly	RB
cord-296585-yfh5d4io	478	10	reduce	reduce	VB
cord-296585-yfh5d4io	478	11	the	the	DT
cord-296585-yfh5d4io	478	12	risk	risk	NN
cord-296585-yfh5d4io	478	13	of	of	IN
cord-296585-yfh5d4io	478	14	treatment	treatment	NN
cord-296585-yfh5d4io	478	15	failure	failure	NN
cord-296585-yfh5d4io	478	16	,	,	,
cord-296585-yfh5d4io	478	17	especially	especially	RB
cord-296585-yfh5d4io	478	18	for	for	IN
cord-296585-yfh5d4io	478	19	in	in	NN
cord-296585-yfh5d4io	478	20	-	-	HYPH
cord-296585-yfh5d4io	478	21	patients	patient	NNS
cord-296585-yfh5d4io	478	22	with	with	IN
cord-296585-yfh5d4io	478	23	severe	severe	JJ
cord-296585-yfh5d4io	478	24	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	478	25	and	and	CC
cord-296585-yfh5d4io	478	26	patients	patient	NNS
cord-296585-yfh5d4io	478	27	requiring	require	VBG
cord-296585-yfh5d4io	478	28	intensive	intensive	JJ
cord-296585-yfh5d4io	478	29	care	care	NN
cord-296585-yfh5d4io	478	30	(	(	-LRB-
cord-296585-yfh5d4io	478	31	323	323	CD
cord-296585-yfh5d4io	478	32	)	)	-RRB-
cord-296585-yfh5d4io	478	33	.	.	.
cord-296585-yfh5d4io	479	1	The	the	DT
cord-296585-yfh5d4io	479	2	efficacity	efficacity	NN
cord-296585-yfh5d4io	479	3	of	of	IN
cord-296585-yfh5d4io	479	4	antibiotic	antibiotic	JJ
cord-296585-yfh5d4io	479	5	treatment	treatment	NN
cord-296585-yfh5d4io	479	6	for	for	IN
cord-296585-yfh5d4io	479	7	out	out	NN
cord-296585-yfh5d4io	479	8	-	-	HYPH
cord-296585-yfh5d4io	479	9	patients	patient	NNS
cord-296585-yfh5d4io	479	10	with	with	IN
cord-296585-yfh5d4io	479	11	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	479	12	is	be	VBZ
cord-296585-yfh5d4io	479	13	less	less	RBR
cord-296585-yfh5d4io	479	14	clear	clear	JJ
cord-296585-yfh5d4io	479	15	(	(	-LRB-
cord-296585-yfh5d4io	479	16	323	323	CD
cord-296585-yfh5d4io	479	17	,	,	,
cord-296585-yfh5d4io	479	18	324	324	CD
cord-296585-yfh5d4io	479	19	)	)	-RRB-
cord-296585-yfh5d4io	479	20	.	.	.
cord-296585-yfh5d4io	480	1	Recommendations	recommendation	NNS
cord-296585-yfh5d4io	480	2	on	on	IN
cord-296585-yfh5d4io	480	3	which	which	WDT
cord-296585-yfh5d4io	480	4	empirical	empirical	JJ
cord-296585-yfh5d4io	480	5	treatment	treatment	NN
cord-296585-yfh5d4io	480	6	to	to	TO
cord-296585-yfh5d4io	480	7	use	use	VB
cord-296585-yfh5d4io	480	8	for	for	IN
cord-296585-yfh5d4io	480	9	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	480	10	varies	vary	VBZ
cord-296585-yfh5d4io	480	11	between	between	IN
cord-296585-yfh5d4io	480	12	different	different	JJ
cord-296585-yfh5d4io	480	13	countries	country	NNS
cord-296585-yfh5d4io	480	14	,	,	,
cord-296585-yfh5d4io	480	15	but	but	CC
cord-296585-yfh5d4io	480	16	common	common	JJ
cord-296585-yfh5d4io	480	17	antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	480	18	agents	agent	NNS
cord-296585-yfh5d4io	480	19	that	that	WDT
cord-296585-yfh5d4io	480	20	are	be	VBP
cord-296585-yfh5d4io	480	21	frequently	frequently	RB
cord-296585-yfh5d4io	480	22	used	use	VBN
cord-296585-yfh5d4io	480	23	as	as	IN
cord-296585-yfh5d4io	480	24	definitive	definitive	JJ
cord-296585-yfh5d4io	480	25	therapy	therapy	NN
cord-296585-yfh5d4io	480	26	against	against	IN
cord-296585-yfh5d4io	480	27	NTHi	NTHi	NNS
cord-296585-yfh5d4io	480	28	include	include	VBP
cord-296585-yfh5d4io	480	29	aminopenicillins	aminopenicillin	NNS
cord-296585-yfh5d4io	480	30	(	(	-LRB-
cord-296585-yfh5d4io	480	31	with	with	IN
cord-296585-yfh5d4io	480	32	or	or	CC
cord-296585-yfh5d4io	480	33	without	without	IN
cord-296585-yfh5d4io	480	34	a	a	DT
cord-296585-yfh5d4io	480	35	beta	beta	NN
cord-296585-yfh5d4io	480	36	-	-	HYPH
cord-296585-yfh5d4io	480	37	lactamase	lactamase	NN
cord-296585-yfh5d4io	480	38	inhibitor	inhibitor	NN
cord-296585-yfh5d4io	480	39	)	)	-RRB-
cord-296585-yfh5d4io	480	40	,	,	,
cord-296585-yfh5d4io	480	41	tetracyclines	tetracycline	NNS
cord-296585-yfh5d4io	480	42	,	,	,
cord-296585-yfh5d4io	480	43	trimethoprimsulfamethoxazole	trimethoprimsulfamethoxazole	NNP
cord-296585-yfh5d4io	480	44	,	,	,
cord-296585-yfh5d4io	480	45	and	and	CC
cord-296585-yfh5d4io	480	46	fluoroquinolones	fluoroquinolone	NNS
cord-296585-yfh5d4io	480	47	.	.	.
cord-296585-yfh5d4io	481	1	In	in	IN
cord-296585-yfh5d4io	481	2	addition	addition	NN
cord-296585-yfh5d4io	481	3	,	,	,
cord-296585-yfh5d4io	481	4	the	the	DT
cord-296585-yfh5d4io	481	5	Clinical	Clinical	NNP
cord-296585-yfh5d4io	481	6	and	and	CC
cord-296585-yfh5d4io	481	7	Laboratory	Laboratory	NNP
cord-296585-yfh5d4io	481	8	Standards	Standards	NNPS
cord-296585-yfh5d4io	481	9	Institute	Institute	NNP
cord-296585-yfh5d4io	481	10	(	(	-LRB-
cord-296585-yfh5d4io	481	11	CLSI	CLSI	NNP
cord-296585-yfh5d4io	481	12	)	)	-RRB-
cord-296585-yfh5d4io	481	13	has	have	VBZ
cord-296585-yfh5d4io	481	14	developed	develop	VBN
cord-296585-yfh5d4io	481	15	clinical	clinical	JJ
cord-296585-yfh5d4io	481	16	breakpoints	breakpoint	NNS
cord-296585-yfh5d4io	481	17	for	for	IN
cord-296585-yfh5d4io	481	18	the	the	DT
cord-296585-yfh5d4io	481	19	macrolides	macrolide	NNS
cord-296585-yfh5d4io	481	20	azithromycin	azithromycin	NNP
cord-296585-yfh5d4io	481	21	and	and	CC
cord-296585-yfh5d4io	481	22	clarithromycin	clarithromycin	NNP
cord-296585-yfh5d4io	481	23	(	(	-LRB-
cord-296585-yfh5d4io	481	24	325	325	CD
cord-296585-yfh5d4io	481	25	)	)	-RRB-
cord-296585-yfh5d4io	481	26	,	,	,
cord-296585-yfh5d4io	481	27	whereas	whereas	IN
cord-296585-yfh5d4io	481	28	the	the	DT
cord-296585-yfh5d4io	481	29	European	European	NNP
cord-296585-yfh5d4io	481	30	Committee	Committee	NNP
cord-296585-yfh5d4io	481	31	on	on	IN
cord-296585-yfh5d4io	481	32	Antimicrobial	Antimicrobial	NNP
cord-296585-yfh5d4io	481	33	Susceptibility	Susceptibility	NNP
cord-296585-yfh5d4io	481	34	Testing	Testing	NNP
cord-296585-yfh5d4io	481	35	(	(	-LRB-
cord-296585-yfh5d4io	481	36	EUCAST	EUCAST	NNP
cord-296585-yfh5d4io	481	37	)	)	-RRB-
cord-296585-yfh5d4io	481	38	have	have	VBP
cord-296585-yfh5d4io	481	39	not	not	RB
cord-296585-yfh5d4io	481	40	set	set	VBN
cord-296585-yfh5d4io	481	41	any	any	DT
cord-296585-yfh5d4io	481	42	clinical	clinical	JJ
cord-296585-yfh5d4io	481	43	breakpoints	breakpoint	NNS
cord-296585-yfh5d4io	481	44	against	against	IN
cord-296585-yfh5d4io	481	45	this	this	DT
cord-296585-yfh5d4io	481	46	class	class	NN
cord-296585-yfh5d4io	481	47	of	of	IN
cord-296585-yfh5d4io	481	48	antibiotics	antibiotic	NNS
cord-296585-yfh5d4io	481	49	due	due	JJ
cord-296585-yfh5d4io	481	50	to	to	IN
cord-296585-yfh5d4io	481	51	lack	lack	NN
cord-296585-yfh5d4io	481	52	of	of	IN
cord-296585-yfh5d4io	481	53	clinical	clinical	JJ
cord-296585-yfh5d4io	481	54	data	datum	NNS
cord-296585-yfh5d4io	481	55	(	(	-LRB-
cord-296585-yfh5d4io	481	56	326	326	CD
cord-296585-yfh5d4io	481	57	)	)	-RRB-
cord-296585-yfh5d4io	481	58	.	.	.
cord-296585-yfh5d4io	482	1	One	one	CD
cord-296585-yfh5d4io	482	2	study	study	NN
cord-296585-yfh5d4io	482	3	shows	show	VBZ
cord-296585-yfh5d4io	482	4	that	that	IN
cord-296585-yfh5d4io	482	5	NTHi	NTHi	VBZ
cord-296585-yfh5d4io	482	6	frequently	frequently	RB
cord-296585-yfh5d4io	482	7	develops	develop	VBZ
cord-296585-yfh5d4io	482	8	resistance	resistance	NN
cord-296585-yfh5d4io	482	9	to	to	IN
cord-296585-yfh5d4io	482	10	macrolides	macrolide	NNS
cord-296585-yfh5d4io	482	11	during	during	IN
cord-296585-yfh5d4io	482	12	prolonged	prolong	VBN
cord-296585-yfh5d4io	482	13	treatment	treatment	NN
cord-296585-yfh5d4io	482	14	and	and	CC
cord-296585-yfh5d4io	482	15	that	that	DT
cord-296585-yfh5d4io	482	16	treatment	treatment	NN
cord-296585-yfh5d4io	482	17	failure	failure	NN
cord-296585-yfh5d4io	482	18	may	may	MD
cord-296585-yfh5d4io	482	19	occur	occur	VB
cord-296585-yfh5d4io	482	20	,	,	,
cord-296585-yfh5d4io	482	21	making	make	VBG
cord-296585-yfh5d4io	482	22	fluoroquinolones	fluoroquinolone	NNS
cord-296585-yfh5d4io	482	23	more	more	RBR
cord-296585-yfh5d4io	482	24	reliable	reliable	JJ
cord-296585-yfh5d4io	482	25	for	for	IN
cord-296585-yfh5d4io	482	26	eradication	eradication	NN
cord-296585-yfh5d4io	482	27	in	in	IN
cord-296585-yfh5d4io	482	28	COPD	COPD	NNP
cord-296585-yfh5d4io	482	29	-	-	HYPH
cord-296585-yfh5d4io	482	30	patients	patient	NNS
cord-296585-yfh5d4io	482	31	(	(	-LRB-
cord-296585-yfh5d4io	482	32	327	327	CD
cord-296585-yfh5d4io	482	33	)	)	-RRB-
cord-296585-yfh5d4io	482	34	.	.	.
cord-296585-yfh5d4io	483	1	As	as	IN
cord-296585-yfh5d4io	483	2	for	for	IN
cord-296585-yfh5d4io	483	3	aminopenicillins	aminopenicillin	NNS
cord-296585-yfh5d4io	483	4	,	,	,
cord-296585-yfh5d4io	483	5	resistance	resistance	NN
cord-296585-yfh5d4io	483	6	is	be	VBZ
cord-296585-yfh5d4io	483	7	also	also	RB
cord-296585-yfh5d4io	483	8	common	common	JJ
cord-296585-yfh5d4io	483	9	,	,	,
cord-296585-yfh5d4io	483	10	with	with	IN
cord-296585-yfh5d4io	483	11	up	up	IN
cord-296585-yfh5d4io	483	12	to	to	TO
cord-296585-yfh5d4io	483	13	10	10	CD
cord-296585-yfh5d4io	483	14	-	-	SYM
cord-296585-yfh5d4io	483	15	20	20	CD
cord-296585-yfh5d4io	483	16	%	%	NN
cord-296585-yfh5d4io	483	17	of	of	IN
cord-296585-yfh5d4io	483	18	NTHi	NTHi	NNS
cord-296585-yfh5d4io	483	19	isolates	isolate	NNS
cord-296585-yfh5d4io	483	20	expressing	express	VBG
cord-296585-yfh5d4io	483	21	beta	beta	NN
cord-296585-yfh5d4io	483	22	-	-	HYPH
cord-296585-yfh5d4io	483	23	lactamases	lactamase	NNS
cord-296585-yfh5d4io	483	24	and	and	CC
cord-296585-yfh5d4io	483	25	an	an	DT
cord-296585-yfh5d4io	483	26	additional	additional	JJ
cord-296585-yfh5d4io	483	27	10	10	CD
cord-296585-yfh5d4io	483	28	-	-	SYM
cord-296585-yfh5d4io	483	29	20	20	CD
cord-296585-yfh5d4io	483	30	%	%	NN
cord-296585-yfh5d4io	483	31	of	of	IN
cord-296585-yfh5d4io	483	32	the	the	DT
cord-296585-yfh5d4io	483	33	isolates	isolate	NNS
cord-296585-yfh5d4io	483	34	having	have	VBG
cord-296585-yfh5d4io	483	35	amino	amino	NN
cord-296585-yfh5d4io	483	36	acid	acid	JJ
cord-296585-yfh5d4io	483	37	substitutions	substitution	NNS
cord-296585-yfh5d4io	483	38	in	in	IN
cord-296585-yfh5d4io	483	39	penicillin	penicillin	NN
cord-296585-yfh5d4io	483	40	-	-	HYPH
cord-296585-yfh5d4io	483	41	binding	bind	VBG
cord-296585-yfh5d4io	483	42	protein	protein	NN
cord-296585-yfh5d4io	483	43	3	3	CD
cord-296585-yfh5d4io	483	44	(	(	-LRB-
cord-296585-yfh5d4io	483	45	PBP3	PBP3	NNP
cord-296585-yfh5d4io	483	46	)	)	-RRB-
cord-296585-yfh5d4io	483	47	,	,	,
cord-296585-yfh5d4io	483	48	which	which	WDT
cord-296585-yfh5d4io	483	49	reduces	reduce	VBZ
cord-296585-yfh5d4io	483	50	their	-PRON-	PRP$
cord-296585-yfh5d4io	483	51	susceptibility	susceptibility	NN
cord-296585-yfh5d4io	483	52	to	to	IN
cord-296585-yfh5d4io	483	53	these	these	DT
cord-296585-yfh5d4io	483	54	agents	agent	NNS
cord-296585-yfh5d4io	483	55	(	(	-LRB-
cord-296585-yfh5d4io	483	56	328	328	CD
cord-296585-yfh5d4io	483	57	,	,	,
cord-296585-yfh5d4io	483	58	329	329	CD
cord-296585-yfh5d4io	483	59	)	)	-RRB-
cord-296585-yfh5d4io	483	60	.	.	.
cord-296585-yfh5d4io	484	1	The	the	DT
cord-296585-yfh5d4io	484	2	fraction	fraction	NN
cord-296585-yfh5d4io	484	3	of	of	IN
cord-296585-yfh5d4io	484	4	isolates	isolate	NNS
cord-296585-yfh5d4io	484	5	expressing	express	VBG
cord-296585-yfh5d4io	484	6	beta	beta	NN
cord-296585-yfh5d4io	484	7	-	-	HYPH
cord-296585-yfh5d4io	484	8	lactamases	lactamase	NNS
cord-296585-yfh5d4io	484	9	has	have	VBZ
cord-296585-yfh5d4io	484	10	been	be	VBN
cord-296585-yfh5d4io	484	11	stable	stable	JJ
cord-296585-yfh5d4io	484	12	during	during	IN
cord-296585-yfh5d4io	484	13	the	the	DT
cord-296585-yfh5d4io	484	14	last	last	JJ
cord-296585-yfh5d4io	484	15	years	year	NNS
cord-296585-yfh5d4io	484	16	,	,	,
cord-296585-yfh5d4io	484	17	whereas	whereas	IN
cord-296585-yfh5d4io	484	18	an	an	DT
cord-296585-yfh5d4io	484	19	increase	increase	NN
cord-296585-yfh5d4io	484	20	has	have	VBZ
cord-296585-yfh5d4io	484	21	been	be	VBN
cord-296585-yfh5d4io	484	22	seen	see	VBN
cord-296585-yfh5d4io	484	23	in	in	IN
cord-296585-yfh5d4io	484	24	isolates	isolate	NNS
cord-296585-yfh5d4io	484	25	displaying	display	VBG
cord-296585-yfh5d4io	484	26	altered	alter	VBN
cord-296585-yfh5d4io	484	27	PBP3	PBP3	NNP
cord-296585-yfh5d4io	484	28	(	(	-LRB-
cord-296585-yfh5d4io	484	29	330	330	CD
cord-296585-yfh5d4io	484	30	,	,	,
cord-296585-yfh5d4io	484	31	331	331	CD
cord-296585-yfh5d4io	484	32	)	)	-RRB-
cord-296585-yfh5d4io	484	33	.	.	.
cord-296585-yfh5d4io	485	1	This	this	DT
cord-296585-yfh5d4io	485	2	is	be	VBZ
cord-296585-yfh5d4io	485	3	worrisome	worrisome	JJ
cord-296585-yfh5d4io	485	4	,	,	,
cord-296585-yfh5d4io	485	5	since	since	IN
cord-296585-yfh5d4io	485	6	some	some	DT
cord-296585-yfh5d4io	485	7	of	of	IN
cord-296585-yfh5d4io	485	8	these	these	DT
cord-296585-yfh5d4io	485	9	amino	amino	NN
cord-296585-yfh5d4io	485	10	acid	acid	NN
cord-296585-yfh5d4io	485	11	substitutions	substitution	NNS
cord-296585-yfh5d4io	485	12	also	also	RB
cord-296585-yfh5d4io	485	13	confer	confer	VBP
cord-296585-yfh5d4io	485	14	resistance	resistance	NN
cord-296585-yfh5d4io	485	15	to	to	IN
cord-296585-yfh5d4io	485	16	third	third	JJ
cord-296585-yfh5d4io	485	17	generation	generation	NN
cord-296585-yfh5d4io	485	18	cephalosporins	cephalosporin	NNS
cord-296585-yfh5d4io	485	19	(	(	-LRB-
cord-296585-yfh5d4io	485	20	332	332	CD
cord-296585-yfh5d4io	485	21	)	)	-RRB-
cord-296585-yfh5d4io	485	22	.	.	.
cord-296585-yfh5d4io	486	1	Moreover	moreover	RB
cord-296585-yfh5d4io	486	2	,	,	,
cord-296585-yfh5d4io	486	3	there	there	EX
cord-296585-yfh5d4io	486	4	seems	seem	VBZ
cord-296585-yfh5d4io	486	5	to	to	TO
cord-296585-yfh5d4io	486	6	be	be	VB
cord-296585-yfh5d4io	486	7	a	a	DT
cord-296585-yfh5d4io	486	8	correlation	correlation	NN
cord-296585-yfh5d4io	486	9	between	between	IN
cord-296585-yfh5d4io	486	10	isolates	isolate	NNS
cord-296585-yfh5d4io	486	11	expressing	express	VBG
cord-296585-yfh5d4io	486	12	altered	alter	VBN
cord-296585-yfh5d4io	486	13	PBP3	PBP3	NNP
cord-296585-yfh5d4io	486	14	and	and	CC
cord-296585-yfh5d4io	486	15	increased	increase	VBN
cord-296585-yfh5d4io	486	16	invasiveness	invasiveness	NN
cord-296585-yfh5d4io	486	17	.	.	.
cord-296585-yfh5d4io	487	1	Studies	study	NNS
cord-296585-yfh5d4io	487	2	have	have	VBP
cord-296585-yfh5d4io	487	3	shown	show	VBN
cord-296585-yfh5d4io	487	4	that	that	IN
cord-296585-yfh5d4io	487	5	strains	strain	NNS
cord-296585-yfh5d4io	487	6	that	that	WDT
cord-296585-yfh5d4io	487	7	express	express	VBP
cord-296585-yfh5d4io	487	8	a	a	DT
cord-296585-yfh5d4io	487	9	mutated	mutate	VBN
cord-296585-yfh5d4io	487	10	PBP3	PBP3	NNP
cord-296585-yfh5d4io	487	11	with	with	IN
cord-296585-yfh5d4io	487	12	certain	certain	JJ
cord-296585-yfh5d4io	487	13	key	key	JJ
cord-296585-yfh5d4io	487	14	amino	amino	NN
cord-296585-yfh5d4io	487	15	acid	acid	NN
cord-296585-yfh5d4io	487	16	substitution	substitution	NN
cord-296585-yfh5d4io	487	17	have	have	VBP
cord-296585-yfh5d4io	487	18	a	a	DT
cord-296585-yfh5d4io	487	19	significantly	significantly	RB
cord-296585-yfh5d4io	487	20	higher	high	JJR
cord-296585-yfh5d4io	487	21	rate	rate	NN
cord-296585-yfh5d4io	487	22	of	of	IN
cord-296585-yfh5d4io	487	23	invasion	invasion	NN
cord-296585-yfh5d4io	487	24	of	of	IN
cord-296585-yfh5d4io	487	25	bronchial	bronchial	JJ
cord-296585-yfh5d4io	487	26	epithelial	epithelial	JJ
cord-296585-yfh5d4io	487	27	cells	cell	NNS
cord-296585-yfh5d4io	487	28	compared	compare	VBN
cord-296585-yfh5d4io	487	29	to	to	IN
cord-296585-yfh5d4io	487	30	strains	strain	NNS
cord-296585-yfh5d4io	487	31	with	with	IN
cord-296585-yfh5d4io	487	32	a	a	DT
cord-296585-yfh5d4io	487	33	wild	wild	JJ
cord-296585-yfh5d4io	487	34	type	type	NN
cord-296585-yfh5d4io	487	35	PBP3	PBP3	NNP
cord-296585-yfh5d4io	487	36	(	(	-LRB-
cord-296585-yfh5d4io	487	37	333	333	CD
cord-296585-yfh5d4io	487	38	)	)	-RRB-
cord-296585-yfh5d4io	487	39	.	.	.
cord-296585-yfh5d4io	488	1	However	however	RB
cord-296585-yfh5d4io	488	2	,	,	,
cord-296585-yfh5d4io	488	3	when	when	WRB
cord-296585-yfh5d4io	488	4	such	such	JJ
cord-296585-yfh5d4io	488	5	mutated	mutate	VBN
cord-296585-yfh5d4io	488	6	PBP3	PBP3	NNP
cord-296585-yfh5d4io	488	7	was	be	VBD
cord-296585-yfh5d4io	488	8	cloned	clone	VBN
cord-296585-yfh5d4io	488	9	into	into	IN
cord-296585-yfh5d4io	488	10	a	a	DT
cord-296585-yfh5d4io	488	11	susceptible	susceptible	JJ
cord-296585-yfh5d4io	488	12	wild	wild	JJ
cord-296585-yfh5d4io	488	13	type	type	NN
cord-296585-yfh5d4io	488	14	strain	strain	NN
cord-296585-yfh5d4io	488	15	,	,	,
cord-296585-yfh5d4io	488	16	invasion	invasion	NN
cord-296585-yfh5d4io	488	17	efficacy	efficacy	NN
cord-296585-yfh5d4io	488	18	did	do	VBD
cord-296585-yfh5d4io	488	19	not	not	RB
cord-296585-yfh5d4io	488	20	increase	increase	VB
cord-296585-yfh5d4io	488	21	,	,	,
cord-296585-yfh5d4io	488	22	suggesting	suggest	VBG
cord-296585-yfh5d4io	488	23	that	that	IN
cord-296585-yfh5d4io	488	24	PBP3	PBP3	NNP
cord-296585-yfh5d4io	488	25	is	be	VBZ
cord-296585-yfh5d4io	488	26	only	only	RB
cord-296585-yfh5d4io	488	27	indirectly	indirectly	RB
cord-296585-yfh5d4io	488	28	linked	link	VBN
cord-296585-yfh5d4io	488	29	to	to	IN
cord-296585-yfh5d4io	488	30	invasion	invasion	NN
cord-296585-yfh5d4io	488	31	(	(	-LRB-
cord-296585-yfh5d4io	488	32	334	334	CD
cord-296585-yfh5d4io	488	33	)	)	-RRB-
cord-296585-yfh5d4io	488	34	.	.	.
cord-296585-yfh5d4io	489	1	Besides	besides	IN
cord-296585-yfh5d4io	489	2	using	use	VBG
cord-296585-yfh5d4io	489	3	antibiotics	antibiotic	NNS
cord-296585-yfh5d4io	489	4	for	for	IN
cord-296585-yfh5d4io	489	5	acute	acute	JJ
cord-296585-yfh5d4io	489	6	management	management	NN
cord-296585-yfh5d4io	489	7	of	of	IN
cord-296585-yfh5d4io	489	8	COPD	COPD	NNP
cord-296585-yfh5d4io	489	9	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	489	10	,	,	,
cord-296585-yfh5d4io	489	11	some	some	DT
cord-296585-yfh5d4io	489	12	studies	study	NNS
cord-296585-yfh5d4io	489	13	have	have	VBP
cord-296585-yfh5d4io	489	14	considered	consider	VBN
cord-296585-yfh5d4io	489	15	the	the	DT
cord-296585-yfh5d4io	489	16	use	use	NN
cord-296585-yfh5d4io	489	17	of	of	IN
cord-296585-yfh5d4io	489	18	continuous	continuous	JJ
cord-296585-yfh5d4io	489	19	prophylactic	prophylactic	JJ
cord-296585-yfh5d4io	489	20	antibiotics	antibiotic	NNS
cord-296585-yfh5d4io	489	21	in	in	IN
cord-296585-yfh5d4io	489	22	the	the	DT
cord-296585-yfh5d4io	489	23	management	management	NN
cord-296585-yfh5d4io	489	24	of	of	IN
cord-296585-yfh5d4io	489	25	patients	patient	NNS
cord-296585-yfh5d4io	489	26	with	with	IN
cord-296585-yfh5d4io	489	27	COPD	COPD	NNP
cord-296585-yfh5d4io	489	28	(	(	-LRB-
cord-296585-yfh5d4io	489	29	212	212	CD
cord-296585-yfh5d4io	489	30	)	)	-RRB-
cord-296585-yfh5d4io	489	31	.	.	.
cord-296585-yfh5d4io	490	1	There	there	EX
cord-296585-yfh5d4io	490	2	is	be	VBZ
cord-296585-yfh5d4io	490	3	some	some	DT
cord-296585-yfh5d4io	490	4	evidence	evidence	NN
cord-296585-yfh5d4io	490	5	that	that	IN
cord-296585-yfh5d4io	490	6	continuous	continuous	JJ
cord-296585-yfh5d4io	490	7	administration	administration	NN
cord-296585-yfh5d4io	490	8	of	of	IN
cord-296585-yfh5d4io	490	9	macrolide	macrolide	JJ
cord-296585-yfh5d4io	490	10	antibiotics	antibiotic	NNS
cord-296585-yfh5d4io	490	11	would	would	MD
cord-296585-yfh5d4io	490	12	prevent	prevent	VB
cord-296585-yfh5d4io	490	13	future	future	JJ
cord-296585-yfh5d4io	490	14	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	490	15	in	in	IN
cord-296585-yfh5d4io	490	16	a	a	DT
cord-296585-yfh5d4io	490	17	selected	select	VBN
cord-296585-yfh5d4io	490	18	population	population	NN
cord-296585-yfh5d4io	490	19	of	of	IN
cord-296585-yfh5d4io	490	20	the	the	DT
cord-296585-yfh5d4io	490	21	most	most	RBS
cord-296585-yfh5d4io	490	22	severely	severely	RB
cord-296585-yfh5d4io	490	23	ill	ill	JJ
cord-296585-yfh5d4io	490	24	patients	patient	NNS
cord-296585-yfh5d4io	490	25	,	,	,
cord-296585-yfh5d4io	490	26	but	but	CC
cord-296585-yfh5d4io	490	27	a	a	DT
cord-296585-yfh5d4io	490	28	Cochrane	Cochrane	NNP
cord-296585-yfh5d4io	490	29	review	review	NN
cord-296585-yfh5d4io	490	30	revealed	reveal	VBD
cord-296585-yfh5d4io	490	31	no	no	DT
cord-296585-yfh5d4io	490	32	support	support	NN
cord-296585-yfh5d4io	490	33	for	for	IN
cord-296585-yfh5d4io	490	34	a	a	DT
cord-296585-yfh5d4io	490	35	reduced	reduce	VBN
cord-296585-yfh5d4io	490	36	all	all	DT
cord-296585-yfh5d4io	490	37	-	-	HYPH
cord-296585-yfh5d4io	490	38	cause	cause	NN
cord-296585-yfh5d4io	490	39	mortality	mortality	NN
cord-296585-yfh5d4io	490	40	or	or	CC
cord-296585-yfh5d4io	490	41	less	less	JJR
cord-296585-yfh5d4io	490	42	hospital	hospital	NN
cord-296585-yfh5d4io	490	43	readmissions	readmission	NNS
cord-296585-yfh5d4io	490	44	(	(	-LRB-
cord-296585-yfh5d4io	490	45	335	335	CD
cord-296585-yfh5d4io	490	46	)	)	-RRB-
cord-296585-yfh5d4io	490	47	.	.	.
cord-296585-yfh5d4io	491	1	However	however	RB
cord-296585-yfh5d4io	491	2	,	,	,
cord-296585-yfh5d4io	491	3	more	more	JJR
cord-296585-yfh5d4io	491	4	recent	recent	JJ
cord-296585-yfh5d4io	491	5	studies	study	NNS
cord-296585-yfh5d4io	491	6	have	have	VBP
cord-296585-yfh5d4io	491	7	shown	show	VBN
cord-296585-yfh5d4io	491	8	a	a	DT
cord-296585-yfh5d4io	491	9	significant	significant	JJ
cord-296585-yfh5d4io	491	10	decrease	decrease	NN
cord-296585-yfh5d4io	491	11	in	in	IN
cord-296585-yfh5d4io	491	12	both	both	CC
cord-296585-yfh5d4io	491	13	the	the	DT
cord-296585-yfh5d4io	491	14	frequency	frequency	NN
cord-296585-yfh5d4io	491	15	of	of	IN
cord-296585-yfh5d4io	491	16	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	491	17	and	and	CC
cord-296585-yfh5d4io	491	18	hospitalizations	hospitalization	NNS
cord-296585-yfh5d4io	491	19	when	when	WRB
cord-296585-yfh5d4io	491	20	long	long	JJ
cord-296585-yfh5d4io	491	21	-	-	HYPH
cord-296585-yfh5d4io	491	22	term	term	NN
cord-296585-yfh5d4io	491	23	azithromycin	azithromycin	NNP
cord-296585-yfh5d4io	491	24	treatment	treatment	NN
cord-296585-yfh5d4io	491	25	was	be	VBD
cord-296585-yfh5d4io	491	26	chosen	choose	VBN
cord-296585-yfh5d4io	491	27	(	(	-LRB-
cord-296585-yfh5d4io	491	28	336	336	CD
cord-296585-yfh5d4io	491	29	)	)	-RRB-
cord-296585-yfh5d4io	491	30	.	.	.
cord-296585-yfh5d4io	492	1	The	the	DT
cord-296585-yfh5d4io	492	2	fact	fact	NN
cord-296585-yfh5d4io	492	3	that	that	IN
cord-296585-yfh5d4io	492	4	macrolide	macrolide	NN
cord-296585-yfh5d4io	492	5	antibiotics	antibiotic	NNS
cord-296585-yfh5d4io	492	6	display	display	VBP
cord-296585-yfh5d4io	492	7	not	not	RB
cord-296585-yfh5d4io	492	8	only	only	RB
cord-296585-yfh5d4io	492	9	antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	492	10	effects	effect	NNS
cord-296585-yfh5d4io	492	11	,	,	,
cord-296585-yfh5d4io	492	12	but	but	CC
cord-296585-yfh5d4io	492	13	also	also	RB
cord-296585-yfh5d4io	492	14	have	have	VBP
cord-296585-yfh5d4io	492	15	anti	anti	JJ
cord-296585-yfh5d4io	492	16	-	-	JJ
cord-296585-yfh5d4io	492	17	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	492	18	and	and	CC
cord-296585-yfh5d4io	492	19	immunomodulatory	immunomodulatory	JJ
cord-296585-yfh5d4io	492	20	properties	property	NNS
cord-296585-yfh5d4io	492	21	,	,	,
cord-296585-yfh5d4io	492	22	has	have	VBZ
cord-296585-yfh5d4io	492	23	made	make	VBN
cord-296585-yfh5d4io	492	24	them	-PRON-	PRP
cord-296585-yfh5d4io	492	25	interesting	interesting	JJ
cord-296585-yfh5d4io	492	26	to	to	TO
cord-296585-yfh5d4io	492	27	use	use	VB
cord-296585-yfh5d4io	492	28	as	as	IN
cord-296585-yfh5d4io	492	29	prophylactic	prophylactic	JJ
cord-296585-yfh5d4io	492	30	therapy	therapy	NN
cord-296585-yfh5d4io	492	31	(	(	-LRB-
cord-296585-yfh5d4io	492	32	212	212	CD
cord-296585-yfh5d4io	492	33	)	)	-RRB-
cord-296585-yfh5d4io	492	34	.	.	.
cord-296585-yfh5d4io	493	1	It	-PRON-	PRP
cord-296585-yfh5d4io	493	2	has	have	VBZ
cord-296585-yfh5d4io	493	3	been	be	VBN
cord-296585-yfh5d4io	493	4	shown	show	VBN
cord-296585-yfh5d4io	493	5	that	that	IN
cord-296585-yfh5d4io	493	6	azithromycin	azithromycin	NNP
cord-296585-yfh5d4io	493	7	inhibits	inhibit	VBZ
cord-296585-yfh5d4io	493	8	mucus	mucus	NN
cord-296585-yfh5d4io	493	9	hypersecretion	hypersecretion	NN
cord-296585-yfh5d4io	493	10	in	in	IN
cord-296585-yfh5d4io	493	11	the	the	DT
cord-296585-yfh5d4io	493	12	respiratory	respiratory	JJ
cord-296585-yfh5d4io	493	13	tract	tract	NN
cord-296585-yfh5d4io	493	14	by	by	IN
cord-296585-yfh5d4io	493	15	significantly	significantly	RB
cord-296585-yfh5d4io	493	16	inhibiting	inhibit	VBG
cord-296585-yfh5d4io	493	17	TNF	TNF	NNP
cord-296585-yfh5d4io	493	18	-	-	HYPH
cord-296585-yfh5d4io	493	19	α	α	NN
cord-296585-yfh5d4io	493	20	induction	induction	NN
cord-296585-yfh5d4io	493	21	of	of	IN
cord-296585-yfh5d4io	493	22	the	the	DT
cord-296585-yfh5d4io	493	23	MUC5AC	MUC5AC	NNP
cord-296585-yfh5d4io	493	24	mucin	mucin	NN
cord-296585-yfh5d4io	493	25	secretion	secretion	NN
cord-296585-yfh5d4io	493	26	from	from	IN
cord-296585-yfh5d4io	493	27	human	human	JJ
cord-296585-yfh5d4io	493	28	nasal	nasal	NN
cord-296585-yfh5d4io	493	29	epithelial	epithelial	JJ
cord-296585-yfh5d4io	493	30	cells	cell	NNS
cord-296585-yfh5d4io	493	31	(	(	-LRB-
cord-296585-yfh5d4io	493	32	337	337	CD
cord-296585-yfh5d4io	493	33	)	)	-RRB-
cord-296585-yfh5d4io	493	34	.	.	.
cord-296585-yfh5d4io	494	1	More	more	RBR
cord-296585-yfh5d4io	494	2	specifically	specifically	RB
cord-296585-yfh5d4io	494	3	,	,	,
cord-296585-yfh5d4io	494	4	it	-PRON-	PRP
cord-296585-yfh5d4io	494	5	has	have	VBZ
cord-296585-yfh5d4io	494	6	been	be	VBN
cord-296585-yfh5d4io	494	7	shown	show	VBN
cord-296585-yfh5d4io	494	8	that	that	IN
cord-296585-yfh5d4io	494	9	azithromycin	azithromycin	NNP
cord-296585-yfh5d4io	494	10	can	can	MD
cord-296585-yfh5d4io	494	11	reduce	reduce	VB
cord-296585-yfh5d4io	494	12	the	the	DT
cord-296585-yfh5d4io	494	13	NTHi	NTHi	NNS
cord-296585-yfh5d4io	494	14	-	-	HYPH
cord-296585-yfh5d4io	494	15	dependent	dependent	JJ
cord-296585-yfh5d4io	494	16	induction	induction	NN
cord-296585-yfh5d4io	494	17	of	of	IN
cord-296585-yfh5d4io	494	18	MUC5AC	MUC5AC	NNP
cord-296585-yfh5d4io	494	19	expression	expression	NN
cord-296585-yfh5d4io	494	20	by	by	IN
cord-296585-yfh5d4io	494	21	suppressing	suppress	VBG
cord-296585-yfh5d4io	494	22	the	the	DT
cord-296585-yfh5d4io	494	23	transcription	transcription	NN
cord-296585-yfh5d4io	494	24	factor	factor	NN
cord-296585-yfh5d4io	494	25	activator	activator	NN
cord-296585-yfh5d4io	494	26	protein-1	protein-1	NNP
cord-296585-yfh5d4io	494	27	(	(	-LRB-
cord-296585-yfh5d4io	494	28	338	338	CD
cord-296585-yfh5d4io	494	29	)	)	-RRB-
cord-296585-yfh5d4io	494	30	.	.	.
cord-296585-yfh5d4io	495	1	Apart	apart	RB
cord-296585-yfh5d4io	495	2	from	from	IN
cord-296585-yfh5d4io	495	3	affecting	affect	VBG
cord-296585-yfh5d4io	495	4	mucus	mucus	NN
cord-296585-yfh5d4io	495	5	secretion	secretion	NN
cord-296585-yfh5d4io	495	6	,	,	,
cord-296585-yfh5d4io	495	7	it	-PRON-	PRP
cord-296585-yfh5d4io	495	8	also	also	RB
cord-296585-yfh5d4io	495	9	seems	seem	VBZ
cord-296585-yfh5d4io	495	10	that	that	IN
cord-296585-yfh5d4io	495	11	low	low	JJ
cord-296585-yfh5d4io	495	12	-	-	HYPH
cord-296585-yfh5d4io	495	13	dose	dose	NN
cord-296585-yfh5d4io	495	14	azithromycin	azithromycin	NN
cord-296585-yfh5d4io	495	15	has	have	VBZ
cord-296585-yfh5d4io	495	16	the	the	DT
cord-296585-yfh5d4io	495	17	ability	ability	NN
cord-296585-yfh5d4io	495	18	to	to	TO
cord-296585-yfh5d4io	495	19	improve	improve	VB
cord-296585-yfh5d4io	495	20	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	495	21	of	of	IN
cord-296585-yfh5d4io	495	22	bacteria	bacteria	NNS
cord-296585-yfh5d4io	495	23	by	by	IN
cord-296585-yfh5d4io	495	24	airway	airway	NN
cord-296585-yfh5d4io	495	25	macrophages	macrophage	NNS
cord-296585-yfh5d4io	495	26	(	(	-LRB-
cord-296585-yfh5d4io	495	27	339	339	CD
cord-296585-yfh5d4io	495	28	)	)	-RRB-
cord-296585-yfh5d4io	495	29	.	.	.
cord-296585-yfh5d4io	496	1	One	one	CD
cord-296585-yfh5d4io	496	2	study	study	NN
cord-296585-yfh5d4io	496	3	showed	show	VBD
cord-296585-yfh5d4io	496	4	that	that	IN
cord-296585-yfh5d4io	496	5	azithromycin	azithromycin	NNP
cord-296585-yfh5d4io	496	6	concentrations	concentration	NNS
cord-296585-yfh5d4io	496	7	that	that	WDT
cord-296585-yfh5d4io	496	8	were	be	VBD
cord-296585-yfh5d4io	496	9	unable	unable	JJ
cord-296585-yfh5d4io	496	10	to	to	TO
cord-296585-yfh5d4io	496	11	kill	kill	VB
cord-296585-yfh5d4io	496	12	NTHi	NTHi	NNS
cord-296585-yfh5d4io	496	13	still	still	RB
cord-296585-yfh5d4io	496	14	increased	increase	VBD
cord-296585-yfh5d4io	496	15	the	the	DT
cord-296585-yfh5d4io	496	16	uptake	uptake	NN
cord-296585-yfh5d4io	496	17	rate	rate	NN
cord-296585-yfh5d4io	496	18	of	of	IN
cord-296585-yfh5d4io	496	19	the	the	DT
cord-296585-yfh5d4io	496	20	bacteria	bacteria	NNS
cord-296585-yfh5d4io	496	21	into	into	IN
cord-296585-yfh5d4io	496	22	alveolar	alveolar	JJ
cord-296585-yfh5d4io	496	23	macrophages	macrophage	NNS
cord-296585-yfh5d4io	496	24	by	by	IN
cord-296585-yfh5d4io	496	25	enhancing	enhance	VBG
cord-296585-yfh5d4io	496	26	their	-PRON-	PRP$
cord-296585-yfh5d4io	496	27	phagocytic	phagocytic	JJ
cord-296585-yfh5d4io	496	28	function	function	NN
cord-296585-yfh5d4io	496	29	(	(	-LRB-
cord-296585-yfh5d4io	496	30	340	340	CD
cord-296585-yfh5d4io	496	31	)	)	-RRB-
cord-296585-yfh5d4io	496	32	.	.	.
cord-296585-yfh5d4io	497	1	However	however	RB
cord-296585-yfh5d4io	497	2	,	,	,
cord-296585-yfh5d4io	497	3	the	the	DT
cord-296585-yfh5d4io	497	4	risk	risk	NN
cord-296585-yfh5d4io	497	5	of	of	IN
cord-296585-yfh5d4io	497	6	development	development	NN
cord-296585-yfh5d4io	497	7	of	of	IN
cord-296585-yfh5d4io	497	8	antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	497	9	resistance	resistance	NN
cord-296585-yfh5d4io	497	10	limits	limit	VBZ
cord-296585-yfh5d4io	497	11	the	the	DT
cord-296585-yfh5d4io	497	12	use	use	NN
cord-296585-yfh5d4io	497	13	of	of	IN
cord-296585-yfh5d4io	497	14	low	low	JJ
cord-296585-yfh5d4io	497	15	-	-	HYPH
cord-296585-yfh5d4io	497	16	dose	dose	NN
cord-296585-yfh5d4io	497	17	azithromycin	azithromycin	NN
cord-296585-yfh5d4io	497	18	solely	solely	RB
cord-296585-yfh5d4io	497	19	for	for	IN
cord-296585-yfh5d4io	497	20	its	-PRON-	PRP$
cord-296585-yfh5d4io	497	21	immunological	immunological	JJ
cord-296585-yfh5d4io	497	22	properties	property	NNS
cord-296585-yfh5d4io	497	23	.	.	.
cord-296585-yfh5d4io	498	1	This	this	DT
cord-296585-yfh5d4io	498	2	has	have	VBZ
cord-296585-yfh5d4io	498	3	triggered	trigger	VBN
cord-296585-yfh5d4io	498	4	an	an	DT
cord-296585-yfh5d4io	498	5	interest	interest	NN
cord-296585-yfh5d4io	498	6	in	in	IN
cord-296585-yfh5d4io	498	7	finding	find	VBG
cord-296585-yfh5d4io	498	8	new	new	JJ
cord-296585-yfh5d4io	498	9	macrolide	macrolide	JJ
cord-296585-yfh5d4io	498	10	substances	substance	NNS
cord-296585-yfh5d4io	498	11	that	that	WDT
cord-296585-yfh5d4io	498	12	lack	lack	VBP
cord-296585-yfh5d4io	498	13	antibiotic	antibiotic	JJ
cord-296585-yfh5d4io	498	14	effect	effect	NN
cord-296585-yfh5d4io	498	15	and	and	CC
cord-296585-yfh5d4io	498	16	solely	solely	RB
cord-296585-yfh5d4io	498	17	interact	interact	VB
cord-296585-yfh5d4io	498	18	with	with	IN
cord-296585-yfh5d4io	498	19	the	the	DT
cord-296585-yfh5d4io	498	20	airway	airway	NN
cord-296585-yfh5d4io	498	21	immune	immune	NN
cord-296585-yfh5d4io	498	22	system	system	NN
cord-296585-yfh5d4io	498	23	(	(	-LRB-
cord-296585-yfh5d4io	498	24	341	341	CD
cord-296585-yfh5d4io	498	25	)	)	-RRB-
cord-296585-yfh5d4io	498	26	.	.	.
cord-296585-yfh5d4io	499	1	The	the	DT
cord-296585-yfh5d4io	499	2	considerable	considerable	JJ
cord-296585-yfh5d4io	499	3	clinical	clinical	JJ
cord-296585-yfh5d4io	499	4	problems	problem	NNS
cord-296585-yfh5d4io	499	5	caused	cause	VBN
cord-296585-yfh5d4io	499	6	by	by	IN
cord-296585-yfh5d4io	499	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	499	8	with	with	IN
cord-296585-yfh5d4io	499	9	regard	regard	NN
cord-296585-yfh5d4io	499	10	to	to	IN
cord-296585-yfh5d4io	499	11	COPD	COPD	NNP
cord-296585-yfh5d4io	499	12	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	499	13	and	and	CC
cord-296585-yfh5d4io	499	14	otitis	otitis	NN
cord-296585-yfh5d4io	499	15	media	medium	NNS
cord-296585-yfh5d4io	499	16	has	have	VBZ
cord-296585-yfh5d4io	499	17	prompted	prompt	VBN
cord-296585-yfh5d4io	499	18	the	the	DT
cord-296585-yfh5d4io	499	19	scientific	scientific	JJ
cord-296585-yfh5d4io	499	20	community	community	NN
cord-296585-yfh5d4io	499	21	to	to	TO
cord-296585-yfh5d4io	499	22	investigate	investigate	VB
cord-296585-yfh5d4io	499	23	whether	whether	IN
cord-296585-yfh5d4io	499	24	a	a	DT
cord-296585-yfh5d4io	499	25	vaccine	vaccine	NN
cord-296585-yfh5d4io	499	26	can	can	MD
cord-296585-yfh5d4io	499	27	be	be	VB
cord-296585-yfh5d4io	499	28	developed	develop	VBN
cord-296585-yfh5d4io	499	29	against	against	IN
cord-296585-yfh5d4io	499	30	the	the	DT
cord-296585-yfh5d4io	499	31	pathogen	pathogen	NN
cord-296585-yfh5d4io	499	32	(	(	-LRB-
cord-296585-yfh5d4io	499	33	5	5	CD
cord-296585-yfh5d4io	499	34	,	,	,
cord-296585-yfh5d4io	499	35	58	58	CD
cord-296585-yfh5d4io	499	36	,	,	,
cord-296585-yfh5d4io	499	37	342	342	CD
cord-296585-yfh5d4io	499	38	)	)	-RRB-
cord-296585-yfh5d4io	499	39	.	.	.
cord-296585-yfh5d4io	500	1	The	the	DT
cord-296585-yfh5d4io	500	2	search	search	NN
cord-296585-yfh5d4io	500	3	has	have	VBZ
cord-296585-yfh5d4io	500	4	been	be	VBN
cord-296585-yfh5d4io	500	5	intensified	intensify	VBN
cord-296585-yfh5d4io	500	6	due	due	IN
cord-296585-yfh5d4io	500	7	to	to	IN
cord-296585-yfh5d4io	500	8	a	a	DT
cord-296585-yfh5d4io	500	9	steady	steady	JJ
cord-296585-yfh5d4io	500	10	increase	increase	NN
cord-296585-yfh5d4io	500	11	in	in	IN
cord-296585-yfh5d4io	500	12	antibiotic	antibiotic	JJ
cord-296585-yfh5d4io	500	13	resistance	resistance	NN
cord-296585-yfh5d4io	500	14	and	and	CC
cord-296585-yfh5d4io	500	15	a	a	DT
cord-296585-yfh5d4io	500	16	trend	trend	NN
cord-296585-yfh5d4io	500	17	of	of	IN
cord-296585-yfh5d4io	500	18	more	more	JJR
cord-296585-yfh5d4io	500	19	invasive	invasive	JJ
cord-296585-yfh5d4io	500	20	infections	infection	NNS
cord-296585-yfh5d4io	500	21	caused	cause	VBN
cord-296585-yfh5d4io	500	22	by	by	IN
cord-296585-yfh5d4io	500	23	NTHi	NTHi	NNS
cord-296585-yfh5d4io	500	24	over	over	IN
cord-296585-yfh5d4io	500	25	the	the	DT
cord-296585-yfh5d4io	500	26	last	last	JJ
cord-296585-yfh5d4io	500	27	decade	decade	NN
cord-296585-yfh5d4io	500	28	(	(	-LRB-
cord-296585-yfh5d4io	500	29	5	5	CD
cord-296585-yfh5d4io	500	30	)	)	-RRB-
cord-296585-yfh5d4io	500	31	.	.	.
cord-296585-yfh5d4io	501	1	Whereas	whereas	IN
cord-296585-yfh5d4io	501	2	,	,	,
cord-296585-yfh5d4io	501	3	a	a	DT
cord-296585-yfh5d4io	501	4	highly	highly	RB
cord-296585-yfh5d4io	501	5	efficient	efficient	JJ
cord-296585-yfh5d4io	501	6	glycoconjugate	glycoconjugate	JJ
cord-296585-yfh5d4io	501	7	vaccine	vaccine	NN
cord-296585-yfh5d4io	501	8	has	have	VBZ
cord-296585-yfh5d4io	501	9	previously	previously	RB
cord-296585-yfh5d4io	501	10	been	be	VBN
cord-296585-yfh5d4io	501	11	developed	develop	VBN
cord-296585-yfh5d4io	501	12	against	against	IN
cord-296585-yfh5d4io	501	13	Hib	Hib	NNP
cord-296585-yfh5d4io	501	14	,	,	,
cord-296585-yfh5d4io	501	15	an	an	DT
cord-296585-yfh5d4io	501	16	identical	identical	JJ
cord-296585-yfh5d4io	501	17	strategy	strategy	NN
cord-296585-yfh5d4io	501	18	can	can	MD
cord-296585-yfh5d4io	501	19	not	not	RB
cord-296585-yfh5d4io	501	20	be	be	VB
cord-296585-yfh5d4io	501	21	employed	employ	VBN
cord-296585-yfh5d4io	501	22	against	against	IN
cord-296585-yfh5d4io	501	23	NTHi	NTHi	NNS
cord-296585-yfh5d4io	501	24	due	due	IN
cord-296585-yfh5d4io	501	25	to	to	IN
cord-296585-yfh5d4io	501	26	the	the	DT
cord-296585-yfh5d4io	501	27	lack	lack	NN
cord-296585-yfh5d4io	501	28	of	of	IN
cord-296585-yfh5d4io	501	29	a	a	DT
cord-296585-yfh5d4io	501	30	polysaccharide	polysaccharide	JJ
cord-296585-yfh5d4io	501	31	capsule	capsule	NN
cord-296585-yfh5d4io	501	32	.	.	.
cord-296585-yfh5d4io	502	1	Vaccine	vaccine	NN
cord-296585-yfh5d4io	502	2	developments	development	NNS
cord-296585-yfh5d4io	502	3	efforts	effort	NNS
cord-296585-yfh5d4io	502	4	have	have	VBP
cord-296585-yfh5d4io	502	5	thus	thus	RB
cord-296585-yfh5d4io	502	6	been	be	VBN
cord-296585-yfh5d4io	502	7	concentrated	concentrate	VBN
cord-296585-yfh5d4io	502	8	on	on	IN
cord-296585-yfh5d4io	502	9	identifying	identify	VBG
cord-296585-yfh5d4io	502	10	NTHi	NTHi	NNS
cord-296585-yfh5d4io	502	11	surface	surface	NN
cord-296585-yfh5d4io	502	12	structures	structure	NNS
cord-296585-yfh5d4io	502	13	that	that	WDT
cord-296585-yfh5d4io	502	14	are	be	VBP
cord-296585-yfh5d4io	502	15	immunogenic	immunogenic	JJ
cord-296585-yfh5d4io	502	16	,	,	,
cord-296585-yfh5d4io	502	17	have	have	VBP
cord-296585-yfh5d4io	502	18	low	low	JJ
cord-296585-yfh5d4io	502	19	antigenic	antigenic	JJ
cord-296585-yfh5d4io	502	20	variability	variability	NN
cord-296585-yfh5d4io	502	21	,	,	,
cord-296585-yfh5d4io	502	22	and	and	CC
cord-296585-yfh5d4io	502	23	are	be	VBP
cord-296585-yfh5d4io	502	24	conserved	conserve	VBN
cord-296585-yfh5d4io	502	25	across	across	IN
cord-296585-yfh5d4io	502	26	this	this	DT
cord-296585-yfh5d4io	502	27	genetically	genetically	RB
cord-296585-yfh5d4io	502	28	highly	highly	RB
cord-296585-yfh5d4io	502	29	heterogeneous	heterogeneous	JJ
cord-296585-yfh5d4io	502	30	species	specie	NNS
cord-296585-yfh5d4io	502	31	.	.	.
cord-296585-yfh5d4io	503	1	Several	several	JJ
cord-296585-yfh5d4io	503	2	promising	promising	JJ
cord-296585-yfh5d4io	503	3	vaccine	vaccine	NN
cord-296585-yfh5d4io	503	4	candidates	candidate	NNS
cord-296585-yfh5d4io	503	5	have	have	VBP
cord-296585-yfh5d4io	503	6	been	be	VBN
cord-296585-yfh5d4io	503	7	identified	identify	VBN
cord-296585-yfh5d4io	503	8	in	in	IN
cord-296585-yfh5d4io	503	9	the	the	DT
cord-296585-yfh5d4io	503	10	last	last	JJ
cord-296585-yfh5d4io	503	11	25	25	CD
cord-296585-yfh5d4io	503	12	years	year	NNS
cord-296585-yfh5d4io	503	13	,	,	,
cord-296585-yfh5d4io	503	14	as	as	IN
cord-296585-yfh5d4io	503	15	excellently	excellently	RB
cord-296585-yfh5d4io	503	16	reviewed	review	VBN
cord-296585-yfh5d4io	503	17	elsewhere	elsewhere	RB
cord-296585-yfh5d4io	503	18	(	(	-LRB-
cord-296585-yfh5d4io	503	19	58	58	CD
cord-296585-yfh5d4io	503	20	,	,	,
cord-296585-yfh5d4io	503	21	342	342	CD
cord-296585-yfh5d4io	503	22	)	)	-RRB-
cord-296585-yfh5d4io	503	23	.	.	.
cord-296585-yfh5d4io	504	1	Two	two	CD
cord-296585-yfh5d4io	504	2	of	of	IN
cord-296585-yfh5d4io	504	3	these	these	DT
cord-296585-yfh5d4io	504	4	antigens	antigen	NNS
cord-296585-yfh5d4io	504	5	,	,	,
cord-296585-yfh5d4io	504	6	fused	fuse	VBN
cord-296585-yfh5d4io	504	7	into	into	IN
cord-296585-yfh5d4io	504	8	one	one	CD
cord-296585-yfh5d4io	504	9	protein	protein	NN
cord-296585-yfh5d4io	504	10	,	,	,
cord-296585-yfh5d4io	504	11	Protein	Protein	NNP
cord-296585-yfh5d4io	504	12	E	E	NNP
cord-296585-yfh5d4io	504	13	-	-	HYPH
cord-296585-yfh5d4io	504	14	PilA	PilA	NNP
cord-296585-yfh5d4io	504	15	,	,	,
cord-296585-yfh5d4io	504	16	are	be	VBP
cord-296585-yfh5d4io	504	17	together	together	RB
cord-296585-yfh5d4io	504	18	with	with	IN
cord-296585-yfh5d4io	504	19	Protein	Protein	NNP
cord-296585-yfh5d4io	504	20	D	D	NNP
cord-296585-yfh5d4io	504	21	currently	currently	RB
cord-296585-yfh5d4io	504	22	being	be	VBG
cord-296585-yfh5d4io	504	23	tested	test	VBN
cord-296585-yfh5d4io	504	24	by	by	IN
cord-296585-yfh5d4io	504	25	GlaxoSmithKline	GlaxoSmithKline	NNP
cord-296585-yfh5d4io	504	26	in	in	IN
cord-296585-yfh5d4io	504	27	a	a	DT
cord-296585-yfh5d4io	504	28	phase	phase	NN
cord-296585-yfh5d4io	504	29	IIb	iib	JJ
cord-296585-yfh5d4io	504	30	proof	proof	NN
cord-296585-yfh5d4io	504	31	-	-	HYPH
cord-296585-yfh5d4io	504	32	of	of	IN
cord-296585-yfh5d4io	504	33	-	-	HYPH
cord-296585-yfh5d4io	504	34	concept	concept	NN
cord-296585-yfh5d4io	504	35	clinical	clinical	JJ
cord-296585-yfh5d4io	504	36	trial	trial	NN
cord-296585-yfh5d4io	504	37	(	(	-LRB-
cord-296585-yfh5d4io	504	38	randomized	randomized	JJ
cord-296585-yfh5d4io	504	39	,	,	,
cord-296585-yfh5d4io	504	40	observer	observer	NN
cord-296585-yfh5d4io	504	41	-	-	HYPH
cord-296585-yfh5d4io	504	42	blind	blind	JJ
cord-296585-yfh5d4io	504	43	,	,	,
cord-296585-yfh5d4io	504	44	placebo	placebo	NN
cord-296585-yfh5d4io	504	45	-	-	HYPH
cord-296585-yfh5d4io	504	46	controlled	control	VBN
cord-296585-yfh5d4io	504	47	,	,	,
cord-296585-yfh5d4io	504	48	and	and	CC
cord-296585-yfh5d4io	504	49	multicentric	multicentric	NNP
cord-296585-yfh5d4io	504	50	)	)	-RRB-
cord-296585-yfh5d4io	504	51	for	for	IN
cord-296585-yfh5d4io	504	52	infection	infection	NN
cord-296585-yfh5d4io	504	53	prophylaxis	prophylaxis	NN
cord-296585-yfh5d4io	504	54	in	in	IN
cord-296585-yfh5d4io	504	55	COPD	COPD	NNP
cord-296585-yfh5d4io	504	56	patients	patient	NNS
cord-296585-yfh5d4io	504	57	(	(	-LRB-
cord-296585-yfh5d4io	504	58	50	50	CD
cord-296585-yfh5d4io	504	59	-	-	SYM
cord-296585-yfh5d4io	504	60	70	70	CD
cord-296585-yfh5d4io	504	61	years	year	NNS
cord-296585-yfh5d4io	504	62	old	old	JJ
cord-296585-yfh5d4io	504	63	)	)	-RRB-
cord-296585-yfh5d4io	504	64	(	(	-LRB-
cord-296585-yfh5d4io	504	65	5	5	CD
cord-296585-yfh5d4io	504	66	)	)	-RRB-
cord-296585-yfh5d4io	504	67	.	.	.
cord-296585-yfh5d4io	505	1	Notably	notably	RB
cord-296585-yfh5d4io	505	2	,	,	,
cord-296585-yfh5d4io	505	3	the	the	DT
cord-296585-yfh5d4io	505	4	M.	M.	NNP
cord-296585-yfh5d4io	505	5	catarrhalis	catarrhalis	NNP
cord-296585-yfh5d4io	505	6	ubiquitous	ubiquitous	JJ
cord-296585-yfh5d4io	505	7	surface	surface	NN
cord-296585-yfh5d4io	505	8	protein	protein	NN
cord-296585-yfh5d4io	505	9	A2	A2	NNP
cord-296585-yfh5d4io	505	10	(	(	-LRB-
cord-296585-yfh5d4io	505	11	UspA2	UspA2	NNP
cord-296585-yfh5d4io	505	12	)	)	-RRB-
cord-296585-yfh5d4io	505	13	is	be	VBZ
cord-296585-yfh5d4io	505	14	also	also	RB
cord-296585-yfh5d4io	505	15	included	include	VBN
cord-296585-yfh5d4io	505	16	in	in	IN
cord-296585-yfh5d4io	505	17	the	the	DT
cord-296585-yfh5d4io	505	18	vaccine	vaccine	NN
cord-296585-yfh5d4io	505	19	so	so	IN
cord-296585-yfh5d4io	505	20	that	that	IN
cord-296585-yfh5d4io	505	21	an	an	DT
cord-296585-yfh5d4io	505	22	immune	immune	JJ
cord-296585-yfh5d4io	505	23	response	response	NN
cord-296585-yfh5d4io	505	24	against	against	IN
cord-296585-yfh5d4io	505	25	both	both	DT
cord-296585-yfh5d4io	505	26	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	505	27	-	-	HYPH
cord-296585-yfh5d4io	505	28	causing	cause	VBG
cord-296585-yfh5d4io	505	29	pathogens	pathogen	NNS
cord-296585-yfh5d4io	505	30	could	could	MD
cord-296585-yfh5d4io	505	31	be	be	VB
cord-296585-yfh5d4io	505	32	elicited	elicit	VBN
cord-296585-yfh5d4io	505	33	by	by	IN
cord-296585-yfh5d4io	505	34	the	the	DT
cord-296585-yfh5d4io	505	35	same	same	JJ
cord-296585-yfh5d4io	505	36	preparation	preparation	NN
cord-296585-yfh5d4io	505	37	.	.	.
cord-296585-yfh5d4io	506	1	This	this	DT
cord-296585-yfh5d4io	506	2	clinical	clinical	JJ
cord-296585-yfh5d4io	506	3	study	study	NN
cord-296585-yfh5d4io	506	4	(	(	-LRB-
cord-296585-yfh5d4io	506	5	NCT03281876	NCT03281876	NNP
cord-296585-yfh5d4io	506	6	)	)	-RRB-
cord-296585-yfh5d4io	506	7	is	be	VBZ
cord-296585-yfh5d4io	506	8	the	the	DT
cord-296585-yfh5d4io	506	9	only	only	JJ
cord-296585-yfh5d4io	506	10	one	one	CD
cord-296585-yfh5d4io	506	11	currently	currently	RB
cord-296585-yfh5d4io	506	12	being	be	VBG
cord-296585-yfh5d4io	506	13	conducted	conduct	VBN
cord-296585-yfh5d4io	506	14	on	on	IN
cord-296585-yfh5d4io	506	15	NTHi	NTHi	NNS
cord-296585-yfh5d4io	506	16	(	(	-LRB-
cord-296585-yfh5d4io	506	17	and	and	CC
cord-296585-yfh5d4io	506	18	M.	M.	NNP
cord-296585-yfh5d4io	506	19	catarrhalis	catarrhalis	NNP
cord-296585-yfh5d4io	506	20	)	)	-RRB-
cord-296585-yfh5d4io	506	21	according	accord	VBG
cord-296585-yfh5d4io	506	22	to	to	IN
cord-296585-yfh5d4io	506	23	clinicaltrials.gov	clinicaltrials.gov	NNP
cord-296585-yfh5d4io	506	24	,	,	,
cord-296585-yfh5d4io	506	25	and	and	CC
cord-296585-yfh5d4io	506	26	as	as	IN
cord-296585-yfh5d4io	506	27	the	the	DT
cord-296585-yfh5d4io	506	28	investigations	investigation	NNS
cord-296585-yfh5d4io	506	29	are	be	VBP
cord-296585-yfh5d4io	506	30	on	on	RB
cord-296585-yfh5d4io	506	31	-	-	HYPH
cord-296585-yfh5d4io	506	32	going	going	NN
cord-296585-yfh5d4io	506	33	,	,	,
cord-296585-yfh5d4io	506	34	the	the	DT
cord-296585-yfh5d4io	506	35	results	result	NNS
cord-296585-yfh5d4io	506	36	are	be	VBP
cord-296585-yfh5d4io	506	37	currently	currently	RB
cord-296585-yfh5d4io	506	38	unknown	unknown	JJ
cord-296585-yfh5d4io	506	39	.	.	.
cord-296585-yfh5d4io	507	1	Due	due	IN
cord-296585-yfh5d4io	507	2	to	to	IN
cord-296585-yfh5d4io	507	3	an	an	DT
cord-296585-yfh5d4io	507	4	increase	increase	NN
cord-296585-yfh5d4io	507	5	in	in	IN
cord-296585-yfh5d4io	507	6	the	the	DT
cord-296585-yfh5d4io	507	7	difficulty	difficulty	NN
cord-296585-yfh5d4io	507	8	to	to	TO
cord-296585-yfh5d4io	507	9	treat	treat	VB
cord-296585-yfh5d4io	507	10	NTHi	NTHi	NNS
cord-296585-yfh5d4io	507	11	infections	infection	NNS
cord-296585-yfh5d4io	507	12	,	,	,
cord-296585-yfh5d4io	507	13	an	an	DT
cord-296585-yfh5d4io	507	14	efficient	efficient	JJ
cord-296585-yfh5d4io	507	15	and	and	CC
cord-296585-yfh5d4io	507	16	protective	protective	JJ
cord-296585-yfh5d4io	507	17	NTHi	NTHi	NNS
cord-296585-yfh5d4io	507	18	vaccine	vaccine	NN
cord-296585-yfh5d4io	507	19	likely	likely	RB
cord-296585-yfh5d4io	507	20	considerably	considerably	RB
cord-296585-yfh5d4io	507	21	raises	raise	VBZ
cord-296585-yfh5d4io	507	22	the	the	DT
cord-296585-yfh5d4io	507	23	quality	quality	NN
cord-296585-yfh5d4io	507	24	of	of	IN
cord-296585-yfh5d4io	507	25	life	life	NN
cord-296585-yfh5d4io	507	26	of	of	IN
cord-296585-yfh5d4io	507	27	COPD	COPD	NNP
cord-296585-yfh5d4io	507	28	patients	patient	NNS
cord-296585-yfh5d4io	507	29	.	.	.
cord-296585-yfh5d4io	508	1	Since	since	IN
cord-296585-yfh5d4io	508	2	NTHi	NTHi	NNS
cord-296585-yfh5d4io	508	3	-	-	HYPH
cord-296585-yfh5d4io	508	4	mediated	mediate	VBN
cord-296585-yfh5d4io	508	5	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	508	6	contribute	contribute	VBP
cord-296585-yfh5d4io	508	7	to	to	IN
cord-296585-yfh5d4io	508	8	the	the	DT
cord-296585-yfh5d4io	508	9	progression	progression	NN
cord-296585-yfh5d4io	508	10	of	of	IN
cord-296585-yfh5d4io	508	11	the	the	DT
cord-296585-yfh5d4io	508	12	disease	disease	NN
cord-296585-yfh5d4io	508	13	and	and	CC
cord-296585-yfh5d4io	508	14	a	a	DT
cord-296585-yfh5d4io	508	15	steady	steady	JJ
cord-296585-yfh5d4io	508	16	deterioration	deterioration	NN
cord-296585-yfh5d4io	508	17	of	of	IN
cord-296585-yfh5d4io	508	18	the	the	DT
cord-296585-yfh5d4io	508	19	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	508	20	capacity	capacity	NN
cord-296585-yfh5d4io	508	21	of	of	IN
cord-296585-yfh5d4io	508	22	those	those	DT
cord-296585-yfh5d4io	508	23	patients	patient	NNS
cord-296585-yfh5d4io	508	24	,	,	,
cord-296585-yfh5d4io	508	25	prevention	prevention	NN
cord-296585-yfh5d4io	508	26	against	against	IN
cord-296585-yfh5d4io	508	27	NTHi	NTHi	NNS
cord-296585-yfh5d4io	508	28	infections	infection	NNS
cord-296585-yfh5d4io	508	29	potentially	potentially	RB
cord-296585-yfh5d4io	508	30	slows	slow	VBZ
cord-296585-yfh5d4io	508	31	down	down	RP
cord-296585-yfh5d4io	508	32	the	the	DT
cord-296585-yfh5d4io	508	33	debilitating	debilitating	JJ
cord-296585-yfh5d4io	508	34	effect	effect	NN
cord-296585-yfh5d4io	508	35	of	of	IN
cord-296585-yfh5d4io	508	36	the	the	DT
cord-296585-yfh5d4io	508	37	disease	disease	NN
cord-296585-yfh5d4io	508	38	.	.	.
cord-296585-yfh5d4io	509	1	It	-PRON-	PRP
cord-296585-yfh5d4io	509	2	is	be	VBZ
cord-296585-yfh5d4io	509	3	therefore	therefore	RB
cord-296585-yfh5d4io	509	4	critical	critical	JJ
cord-296585-yfh5d4io	509	5	to	to	TO
cord-296585-yfh5d4io	509	6	continue	continue	VB
cord-296585-yfh5d4io	509	7	this	this	DT
cord-296585-yfh5d4io	509	8	line	line	NN
cord-296585-yfh5d4io	509	9	of	of	IN
cord-296585-yfh5d4io	509	10	research	research	NN
cord-296585-yfh5d4io	509	11	until	until	IN
cord-296585-yfh5d4io	509	12	such	such	PDT
cord-296585-yfh5d4io	509	13	a	a	DT
cord-296585-yfh5d4io	509	14	vaccine	vaccine	NN
cord-296585-yfh5d4io	509	15	has	have	VBZ
cord-296585-yfh5d4io	509	16	been	be	VBN
cord-296585-yfh5d4io	509	17	obtained	obtain	VBN
cord-296585-yfh5d4io	509	18	.	.	.
cord-296585-yfh5d4io	510	1	It	-PRON-	PRP
cord-296585-yfh5d4io	510	2	could	could	MD
cord-296585-yfh5d4io	510	3	also	also	RB
cord-296585-yfh5d4io	510	4	be	be	VB
cord-296585-yfh5d4io	510	5	worth	worth	JJ
cord-296585-yfh5d4io	510	6	targeting	target	VBG
cord-296585-yfh5d4io	510	7	non	non	JJ
cord-296585-yfh5d4io	510	8	-	-	JJ
cord-296585-yfh5d4io	510	9	conventional	conventional	JJ
cord-296585-yfh5d4io	510	10	structures	structure	NNS
cord-296585-yfh5d4io	510	11	with	with	IN
cord-296585-yfh5d4io	510	12	a	a	DT
cord-296585-yfh5d4io	510	13	vaccine	vaccine	NN
cord-296585-yfh5d4io	510	14	,	,	,
cord-296585-yfh5d4io	510	15	such	such	JJ
cord-296585-yfh5d4io	510	16	as	as	IN
cord-296585-yfh5d4io	510	17	the	the	DT
cord-296585-yfh5d4io	510	18	secreted	secrete	VBN
cord-296585-yfh5d4io	510	19	enzymes	enzyme	NNS
cord-296585-yfh5d4io	510	20	urease	urease	NN
cord-296585-yfh5d4io	510	21	and	and	CC
cord-296585-yfh5d4io	510	22	IgA1protease	iga1protease	NN
cord-296585-yfh5d4io	510	23	that	that	WDT
cord-296585-yfh5d4io	510	24	have	have	VBP
cord-296585-yfh5d4io	510	25	proven	prove	VBN
cord-296585-yfh5d4io	510	26	important	important	JJ
cord-296585-yfh5d4io	510	27	for	for	IN
cord-296585-yfh5d4io	510	28	NTHi	NTHi	NNS
cord-296585-yfh5d4io	510	29	infections	infection	NNS
cord-296585-yfh5d4io	510	30	in	in	IN
cord-296585-yfh5d4io	510	31	COPD	COPD	NNP
cord-296585-yfh5d4io	510	32	patients	patient	NNS
cord-296585-yfh5d4io	510	33	in	in	IN
cord-296585-yfh5d4io	510	34	several	several	JJ
cord-296585-yfh5d4io	510	35	studies	study	NNS
cord-296585-yfh5d4io	510	36	(	(	-LRB-
cord-296585-yfh5d4io	510	37	222	222	CD
cord-296585-yfh5d4io	510	38	)	)	-RRB-
cord-296585-yfh5d4io	510	39	.	.	.
cord-296585-yfh5d4io	511	1	COPD	COPD	NNP
cord-296585-yfh5d4io	511	2	is	be	VBZ
cord-296585-yfh5d4io	511	3	a	a	DT
cord-296585-yfh5d4io	511	4	multifaceted	multifaceted	JJ
cord-296585-yfh5d4io	511	5	airway	airway	NN
cord-296585-yfh5d4io	511	6	disease	disease	NN
cord-296585-yfh5d4io	511	7	.	.	.
cord-296585-yfh5d4io	512	1	Several	several	JJ
cord-296585-yfh5d4io	512	2	factors	factor	NNS
cord-296585-yfh5d4io	512	3	influence	influence	VBP
cord-296585-yfh5d4io	512	4	the	the	DT
cord-296585-yfh5d4io	512	5	clinical	clinical	JJ
cord-296585-yfh5d4io	512	6	outcome	outcome	NN
cord-296585-yfh5d4io	512	7	of	of	IN
cord-296585-yfh5d4io	512	8	COPD	COPD	NNP
cord-296585-yfh5d4io	512	9	.	.	.
cord-296585-yfh5d4io	513	1	Importantly	importantly	RB
cord-296585-yfh5d4io	513	2	,	,	,
cord-296585-yfh5d4io	513	3	the	the	DT
cord-296585-yfh5d4io	513	4	crosstalk	crosstalk	NN
cord-296585-yfh5d4io	513	5	between	between	IN
cord-296585-yfh5d4io	513	6	intrinsic	intrinsic	JJ
cord-296585-yfh5d4io	513	7	factors	factor	NNS
cord-296585-yfh5d4io	513	8	(	(	-LRB-
cord-296585-yfh5d4io	513	9	the	the	DT
cord-296585-yfh5d4io	513	10	stability	stability	NN
cord-296585-yfh5d4io	513	11	and	and	CC
cord-296585-yfh5d4io	513	12	integrity	integrity	NN
cord-296585-yfh5d4io	513	13	of	of	IN
cord-296585-yfh5d4io	513	14	the	the	DT
cord-296585-yfh5d4io	513	15	airway	airway	NN
cord-296585-yfh5d4io	513	16	immune	immune	JJ
cord-296585-yfh5d4io	513	17	response	response	NN
cord-296585-yfh5d4io	513	18	and	and	CC
cord-296585-yfh5d4io	513	19	structure	structure	NN
cord-296585-yfh5d4io	513	20	in	in	IN
cord-296585-yfh5d4io	513	21	addition	addition	NN
cord-296585-yfh5d4io	513	22	to	to	IN
cord-296585-yfh5d4io	513	23	hereditary	hereditary	JJ
cord-296585-yfh5d4io	513	24	factors	factor	NNS
cord-296585-yfh5d4io	513	25	)	)	-RRB-
cord-296585-yfh5d4io	513	26	,	,	,
cord-296585-yfh5d4io	513	27	and	and	CC
cord-296585-yfh5d4io	513	28	the	the	DT
cord-296585-yfh5d4io	513	29	extrinsic	extrinsic	JJ
cord-296585-yfh5d4io	513	30	factors	factor	NNS
cord-296585-yfh5d4io	513	31	(	(	-LRB-
cord-296585-yfh5d4io	513	32	lung	lung	NN
cord-296585-yfh5d4io	513	33	microbiome	microbiome	NN
cord-296585-yfh5d4io	513	34	,	,	,
cord-296585-yfh5d4io	513	35	viral	viral	JJ
cord-296585-yfh5d4io	513	36	and	and	CC
cord-296585-yfh5d4io	513	37	bacterial	bacterial	JJ
cord-296585-yfh5d4io	513	38	infections	infection	NNS
cord-296585-yfh5d4io	513	39	,	,	,
cord-296585-yfh5d4io	513	40	meteorological	meteorological	JJ
cord-296585-yfh5d4io	513	41	factors	factor	NNS
cord-296585-yfh5d4io	513	42	,	,	,
cord-296585-yfh5d4io	513	43	and	and	CC
cord-296585-yfh5d4io	513	44	noxious	noxious	JJ
cord-296585-yfh5d4io	513	45	inhalation	inhalation	NN
cord-296585-yfh5d4io	513	46	)	)	-RRB-
cord-296585-yfh5d4io	513	47	determines	determine	VBZ
cord-296585-yfh5d4io	513	48	the	the	DT
cord-296585-yfh5d4io	513	49	fate	fate	NN
cord-296585-yfh5d4io	513	50	of	of	IN
cord-296585-yfh5d4io	513	51	lower	low	JJR
cord-296585-yfh5d4io	513	52	airway	airway	NN
cord-296585-yfh5d4io	513	53	opportunistic	opportunistic	JJ
cord-296585-yfh5d4io	513	54	infection	infection	NN
cord-296585-yfh5d4io	513	55	by	by	IN
cord-296585-yfh5d4io	513	56	H.	H.	NNP
cord-296585-yfh5d4io	513	57	influenzae	influenzae	NN
cord-296585-yfh5d4io	513	58	.	.	.
cord-296585-yfh5d4io	514	1	Intriguingly	intriguingly	RB
cord-296585-yfh5d4io	514	2	,	,	,
cord-296585-yfh5d4io	514	3	NTHi	NTHi	NNP
cord-296585-yfh5d4io	514	4	has	have	VBZ
cord-296585-yfh5d4io	514	5	been	be	VBN
cord-296585-yfh5d4io	514	6	one	one	CD
cord-296585-yfh5d4io	514	7	of	of	IN
cord-296585-yfh5d4io	514	8	the	the	DT
cord-296585-yfh5d4io	514	9	most	most	RBS
cord-296585-yfh5d4io	514	10	isolated	isolated	JJ
cord-296585-yfh5d4io	514	11	pathogens	pathogen	NNS
cord-296585-yfh5d4io	514	12	at	at	IN
cord-296585-yfh5d4io	514	13	both	both	CC
cord-296585-yfh5d4io	514	14	stable	stable	JJ
cord-296585-yfh5d4io	514	15	and	and	CC
cord-296585-yfh5d4io	514	16	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	514	17	states	state	NNS
cord-296585-yfh5d4io	514	18	of	of	IN
cord-296585-yfh5d4io	514	19	COPD	COPD	NNP
cord-296585-yfh5d4io	514	20	.	.	.
cord-296585-yfh5d4io	515	1	Such	such	JJ
cord-296585-yfh5d4io	515	2	persistent	persistent	JJ
cord-296585-yfh5d4io	515	3	airway	airway	NN
cord-296585-yfh5d4io	515	4	colonization	colonization	NN
cord-296585-yfh5d4io	515	5	of	of	IN
cord-296585-yfh5d4io	515	6	NTHi	NTHi	NNS
cord-296585-yfh5d4io	515	7	costs	cost	VBZ
cord-296585-yfh5d4io	515	8	virulence	virulence	NN
cord-296585-yfh5d4io	515	9	fitness	fitness	NN
cord-296585-yfh5d4io	515	10	to	to	TO
cord-296585-yfh5d4io	515	11	counteract	counteract	VB
cord-296585-yfh5d4io	515	12	with	with	IN
cord-296585-yfh5d4io	515	13	the	the	DT
cord-296585-yfh5d4io	515	14	bactericidal	bactericidal	JJ
cord-296585-yfh5d4io	515	15	effect	effect	NN
cord-296585-yfh5d4io	515	16	of	of	IN
cord-296585-yfh5d4io	515	17	the	the	DT
cord-296585-yfh5d4io	515	18	host	host	NN
cord-296585-yfh5d4io	515	19	immune	immune	JJ
cord-296585-yfh5d4io	515	20	response	response	NN
cord-296585-yfh5d4io	515	21	.	.	.
cord-296585-yfh5d4io	516	1	Adversely	adversely	RB
cord-296585-yfh5d4io	516	2	,	,	,
cord-296585-yfh5d4io	516	3	the	the	DT
cord-296585-yfh5d4io	516	4	impaired	impair	VBN
cord-296585-yfh5d4io	516	5	defense	defense	NN
cord-296585-yfh5d4io	516	6	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	516	7	in	in	IN
cord-296585-yfh5d4io	516	8	COPD	COPD	NNP
cord-296585-yfh5d4io	516	9	are	be	VBP
cord-296585-yfh5d4io	516	10	not	not	RB
cord-296585-yfh5d4io	516	11	only	only	RB
cord-296585-yfh5d4io	516	12	unable	unable	JJ
cord-296585-yfh5d4io	516	13	to	to	TO
cord-296585-yfh5d4io	516	14	protect	protect	VB
cord-296585-yfh5d4io	516	15	the	the	DT
cord-296585-yfh5d4io	516	16	lung	lung	NN
cord-296585-yfh5d4io	516	17	structure	structure	NN
cord-296585-yfh5d4io	516	18	from	from	IN
cord-296585-yfh5d4io	516	19	inhaled	inhale	VBN
cord-296585-yfh5d4io	516	20	physical	physical	JJ
cord-296585-yfh5d4io	516	21	assaults	assault	NNS
cord-296585-yfh5d4io	516	22	,	,	,
cord-296585-yfh5d4io	516	23	but	but	CC
cord-296585-yfh5d4io	516	24	they	-PRON-	PRP
cord-296585-yfh5d4io	516	25	also	also	RB
cord-296585-yfh5d4io	516	26	fail	fail	VBP
cord-296585-yfh5d4io	516	27	to	to	TO
cord-296585-yfh5d4io	516	28	suppress	suppress	VB
cord-296585-yfh5d4io	516	29	NTHi	nthi	JJ
cord-296585-yfh5d4io	516	30	infection	infection	NN
cord-296585-yfh5d4io	516	31	.	.	.
cord-296585-yfh5d4io	517	1	The	the	DT
cord-296585-yfh5d4io	517	2	disoriented	disoriented	JJ
cord-296585-yfh5d4io	517	3	immune	immune	JJ
cord-296585-yfh5d4io	517	4	response	response	NN
cord-296585-yfh5d4io	517	5	in	in	IN
cord-296585-yfh5d4io	517	6	COPD	COPD	NNP
cord-296585-yfh5d4io	517	7	instead	instead	RB
cord-296585-yfh5d4io	517	8	allows	allow	VBZ
cord-296585-yfh5d4io	517	9	the	the	DT
cord-296585-yfh5d4io	517	10	pathogen	pathogen	NN
cord-296585-yfh5d4io	517	11	to	to	TO
cord-296585-yfh5d4io	517	12	cause	cause	VB
cord-296585-yfh5d4io	517	13	more	more	JJR
cord-296585-yfh5d4io	517	14	harm	harm	NN
cord-296585-yfh5d4io	517	15	and	and	CC
cord-296585-yfh5d4io	517	16	inflammation	inflammation	NN
cord-296585-yfh5d4io	517	17	in	in	IN
cord-296585-yfh5d4io	517	18	the	the	DT
cord-296585-yfh5d4io	517	19	airways	airway	NNS
cord-296585-yfh5d4io	517	20	.	.	.
cord-296585-yfh5d4io	518	1	The	the	DT
cord-296585-yfh5d4io	518	2	currently	currently	RB
cord-296585-yfh5d4io	518	3	used	use	VBN
cord-296585-yfh5d4io	518	4	bronchodilator	bronchodilator	NN
cord-296585-yfh5d4io	518	5	and	and	CC
cord-296585-yfh5d4io	518	6	inhaled	inhale	VBN
cord-296585-yfh5d4io	518	7	corticosteroid	corticosteroid	NN
cord-296585-yfh5d4io	518	8	therapies	therapy	NNS
cord-296585-yfh5d4io	518	9	have	have	VBP
cord-296585-yfh5d4io	518	10	limited	limit	VBN
cord-296585-yfh5d4io	518	11	efficacy	efficacy	NN
cord-296585-yfh5d4io	518	12	in	in	IN
cord-296585-yfh5d4io	518	13	preventing	prevent	VBG
cord-296585-yfh5d4io	518	14	disease	disease	NN
cord-296585-yfh5d4io	518	15	progression	progression	NN
cord-296585-yfh5d4io	518	16	in	in	IN
cord-296585-yfh5d4io	518	17	COPD	COPD	NNP
cord-296585-yfh5d4io	518	18	.	.	.
cord-296585-yfh5d4io	519	1	Moreover	moreover	RB
cord-296585-yfh5d4io	519	2	,	,	,
cord-296585-yfh5d4io	519	3	the	the	DT
cord-296585-yfh5d4io	519	4	inhaled	inhale	VBN
cord-296585-yfh5d4io	519	5	corticosteroid	corticosteroid	NN
cord-296585-yfh5d4io	519	6	therapies	therapy	NNS
cord-296585-yfh5d4io	519	7	might	may	MD
cord-296585-yfh5d4io	519	8	have	have	VB
cord-296585-yfh5d4io	519	9	side	side	JJ
cord-296585-yfh5d4io	519	10	effects	effect	NNS
cord-296585-yfh5d4io	519	11	that	that	WDT
cord-296585-yfh5d4io	519	12	may	may	MD
cord-296585-yfh5d4io	519	13	weaken	weaken	VB
cord-296585-yfh5d4io	519	14	the	the	DT
cord-296585-yfh5d4io	519	15	immune	immune	JJ
cord-296585-yfh5d4io	519	16	response	response	NN
cord-296585-yfh5d4io	519	17	.	.	.
cord-296585-yfh5d4io	520	1	Hence	hence	RB
cord-296585-yfh5d4io	520	2	,	,	,
cord-296585-yfh5d4io	520	3	more	more	JJR
cord-296585-yfh5d4io	520	4	investigations	investigation	NNS
cord-296585-yfh5d4io	520	5	are	be	VBP
cord-296585-yfh5d4io	520	6	needed	need	VBN
cord-296585-yfh5d4io	520	7	to	to	TO
cord-296585-yfh5d4io	520	8	garner	garner	VB
cord-296585-yfh5d4io	520	9	a	a	DT
cord-296585-yfh5d4io	520	10	more	more	RBR
cord-296585-yfh5d4io	520	11	adequate	adequate	JJ
cord-296585-yfh5d4io	520	12	knowledge	knowledge	NN
cord-296585-yfh5d4io	520	13	regarding	regard	VBG
cord-296585-yfh5d4io	520	14	the	the	DT
cord-296585-yfh5d4io	520	15	variabilities	variability	NNS
cord-296585-yfh5d4io	520	16	in	in	IN
cord-296585-yfh5d4io	520	17	immune	immune	JJ
cord-296585-yfh5d4io	520	18	networking	networking	NN
cord-296585-yfh5d4io	520	19	of	of	IN
cord-296585-yfh5d4io	520	20	COPD	COPD	NNP
cord-296585-yfh5d4io	520	21	.	.	.
cord-296585-yfh5d4io	521	1	This	this	DT
cord-296585-yfh5d4io	521	2	knowledge	knowledge	NN
cord-296585-yfh5d4io	521	3	will	will	MD
cord-296585-yfh5d4io	521	4	be	be	VB
cord-296585-yfh5d4io	521	5	an	an	DT
cord-296585-yfh5d4io	521	6	important	important	JJ
cord-296585-yfh5d4io	521	7	platform	platform	NN
cord-296585-yfh5d4io	521	8	for	for	IN
cord-296585-yfh5d4io	521	9	a	a	DT
cord-296585-yfh5d4io	521	10	more	more	RBR
cord-296585-yfh5d4io	521	11	efficient	efficient	JJ
cord-296585-yfh5d4io	521	12	drug	drug	NN
cord-296585-yfh5d4io	521	13	design	design	NN
cord-296585-yfh5d4io	521	14	.	.	.
cord-296585-yfh5d4io	522	1	In	in	IN
cord-296585-yfh5d4io	522	2	addition	addition	NN
cord-296585-yfh5d4io	522	3	,	,	,
cord-296585-yfh5d4io	522	4	a	a	DT
cord-296585-yfh5d4io	522	5	vaccine	vaccine	NN
cord-296585-yfh5d4io	522	6	targeting	target	VBG
cord-296585-yfh5d4io	522	7	NTHi	NTHi	NNS
cord-296585-yfh5d4io	522	8	is	be	VBZ
cord-296585-yfh5d4io	522	9	another	another	DT
cord-296585-yfh5d4io	522	10	important	important	JJ
cord-296585-yfh5d4io	522	11	approach	approach	NN
cord-296585-yfh5d4io	522	12	in	in	IN
cord-296585-yfh5d4io	522	13	controlling	control	VBG
cord-296585-yfh5d4io	522	14	the	the	DT
cord-296585-yfh5d4io	522	15	infective	infective	JJ
cord-296585-yfh5d4io	522	16	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	522	17	in	in	IN
cord-296585-yfh5d4io	522	18	COPD	COPD	NNP
cord-296585-yfh5d4io	522	19	as	as	IN
cord-296585-yfh5d4io	522	20	the	the	DT
cord-296585-yfh5d4io	522	21	antibiotic	antibiotic	JJ
cord-296585-yfh5d4io	522	22	treatment	treatment	NN
cord-296585-yfh5d4io	522	23	is	be	VBZ
cord-296585-yfh5d4io	522	24	also	also	RB
cord-296585-yfh5d4io	522	25	getting	get	VBG
cord-296585-yfh5d4io	522	26	dampened	dampen	VBN
cord-296585-yfh5d4io	522	27	by	by	IN
cord-296585-yfh5d4io	522	28	the	the	DT
cord-296585-yfh5d4io	522	29	emergence	emergence	NN
cord-296585-yfh5d4io	522	30	of	of	IN
cord-296585-yfh5d4io	522	31	NTHi	NTHi	NNS
cord-296585-yfh5d4io	522	32	antibiotic	antibiotic	JJ
cord-296585-yfh5d4io	522	33	resistance	resistance	NN
cord-296585-yfh5d4io	522	34	.	.	.
cord-296585-yfh5d4io	523	1	Y	Y	NNP
cord-296585-yfh5d4io	523	2	-	-	HYPH
cord-296585-yfh5d4io	523	3	CS	CS	NNP
cord-296585-yfh5d4io	523	4	coordinated	coordinate	VBD
cord-296585-yfh5d4io	523	5	and	and	CC
cord-296585-yfh5d4io	523	6	drafted	draft	VBD
cord-296585-yfh5d4io	523	7	the	the	DT
cord-296585-yfh5d4io	523	8	major	major	JJ
cord-296585-yfh5d4io	523	9	part	part	NN
cord-296585-yfh5d4io	523	10	of	of	IN
cord-296585-yfh5d4io	523	11	the	the	DT
cord-296585-yfh5d4io	523	12	manuscript	manuscript	NN
cord-296585-yfh5d4io	523	13	,	,	,
cord-296585-yfh5d4io	523	14	and	and	CC
cord-296585-yfh5d4io	523	15	prepared	prepare	VBD
cord-296585-yfh5d4io	523	16	the	the	DT
cord-296585-yfh5d4io	523	17	figures	figure	NNS
cord-296585-yfh5d4io	523	18	;	;	:
cord-296585-yfh5d4io	523	19	FJ	FJ	NNP
cord-296585-yfh5d4io	523	20	participated	participate	VBD
cord-296585-yfh5d4io	523	21	in	in	IN
cord-296585-yfh5d4io	523	22	the	the	DT
cord-296585-yfh5d4io	523	23	literature	literature	NN
cord-296585-yfh5d4io	523	24	study	study	NN
cord-296585-yfh5d4io	523	25	of	of	IN
cord-296585-yfh5d4io	523	26	virulence	virulence	NN
cord-296585-yfh5d4io	523	27	and	and	CC
cord-296585-yfh5d4io	523	28	vaccine	vaccine	NN
cord-296585-yfh5d4io	523	29	research	research	NN
cord-296585-yfh5d4io	523	30	of	of	IN
cord-296585-yfh5d4io	523	31	NTHi	NTHi	NNS
cord-296585-yfh5d4io	523	32	;	;	:
cord-296585-yfh5d4io	523	33	JT	JT	NNP
cord-296585-yfh5d4io	523	34	prepared	prepare	VBD
cord-296585-yfh5d4io	523	35	the	the	DT
cord-296585-yfh5d4io	523	36	review	review	NN
cord-296585-yfh5d4io	523	37	section	section	NN
cord-296585-yfh5d4io	523	38	for	for	IN
cord-296585-yfh5d4io	523	39	NTHi	NTHi	NNS
cord-296585-yfh5d4io	523	40	epidemiology	epidemiology	NN
cord-296585-yfh5d4io	523	41	in	in	IN
cord-296585-yfh5d4io	523	42	COPD	COPD	NNP
cord-296585-yfh5d4io	523	43	and	and	CC
cord-296585-yfh5d4io	523	44	antibiotic	antibiotic	JJ
cord-296585-yfh5d4io	523	45	studies	study	NNS
cord-296585-yfh5d4io	523	46	;	;	:
cord-296585-yfh5d4io	523	47	Y	Y	NNP
cord-296585-yfh5d4io	523	48	-	-	HYPH
cord-296585-yfh5d4io	523	49	CS	CS	NNP
cord-296585-yfh5d4io	523	50	and	and	CC
cord-296585-yfh5d4io	523	51	KR	KR	NNP
cord-296585-yfh5d4io	523	52	edited	edit	VBD
cord-296585-yfh5d4io	523	53	and	and	CC
cord-296585-yfh5d4io	523	54	critically	critically	RB
cord-296585-yfh5d4io	523	55	revised	revise	VBD
cord-296585-yfh5d4io	523	56	the	the	DT
cord-296585-yfh5d4io	523	57	manuscript	manuscript	NN
cord-296585-yfh5d4io	523	58	.	.	.
cord-296585-yfh5d4io	524	1	All	all	DT
cord-296585-yfh5d4io	524	2	authors	author	NNS
cord-296585-yfh5d4io	524	3	read	read	VBP
cord-296585-yfh5d4io	524	4	and	and	CC
cord-296585-yfh5d4io	524	5	approved	approve	VBD
cord-296585-yfh5d4io	524	6	the	the	DT
cord-296585-yfh5d4io	524	7	final	final	JJ
cord-296585-yfh5d4io	524	8	manuscript	manuscript	NN
cord-296585-yfh5d4io	524	9	.	.	.
cord-296585-yfh5d4io	524	10	 	 	_SP
cord-296585-yfh5d4io	525	1	Topographical	topographical	JJ
cord-296585-yfh5d4io	525	2	continuity	continuity	NN
cord-296585-yfh5d4io	525	3	of	of	IN
cord-296585-yfh5d4io	525	4	bacterial	bacterial	JJ
cord-296585-yfh5d4io	525	5	populations	population	NNS
cord-296585-yfh5d4io	525	6	in	in	IN
cord-296585-yfh5d4io	525	7	the	the	DT
cord-296585-yfh5d4io	525	8	healthy	healthy	JJ
cord-296585-yfh5d4io	525	9	human	human	JJ
cord-296585-yfh5d4io	525	10	respiratory	respiratory	JJ
cord-296585-yfh5d4io	525	11	tract	tract	NN
cord-296585-yfh5d4io	525	12	Bacterial	bacterial	JJ
cord-296585-yfh5d4io	525	13	topography	topography	NN
cord-296585-yfh5d4io	525	14	of	of	IN
cord-296585-yfh5d4io	525	15	the	the	DT
cord-296585-yfh5d4io	525	16	healthy	healthy	JJ
cord-296585-yfh5d4io	525	17	human	human	JJ
cord-296585-yfh5d4io	525	18	lower	low	JJR
cord-296585-yfh5d4io	525	19	respiratory	respiratory	JJ
cord-296585-yfh5d4io	525	20	tract	tract	NN
cord-296585-yfh5d4io	526	1	The	the	DT
cord-296585-yfh5d4io	526	2	microbiota	microbiota	NN
cord-296585-yfh5d4io	526	3	of	of	IN
cord-296585-yfh5d4io	526	4	the	the	DT
cord-296585-yfh5d4io	526	5	respiratory	respiratory	JJ
cord-296585-yfh5d4io	526	6	tract	tract	NN
cord-296585-yfh5d4io	526	7	:	:	:
cord-296585-yfh5d4io	526	8	gatekeeper	gatekeeper	NN
cord-296585-yfh5d4io	526	9	to	to	IN
cord-296585-yfh5d4io	526	10	respiratory	respiratory	JJ
cord-296585-yfh5d4io	526	11	health	health	NN
cord-296585-yfh5d4io	526	12	Host	host	NN
cord-296585-yfh5d4io	526	13	-	-	HYPH
cord-296585-yfh5d4io	526	14	pathogen	pathogen	NN
cord-296585-yfh5d4io	526	15	interactions	interaction	NNS
cord-296585-yfh5d4io	526	16	of	of	IN
cord-296585-yfh5d4io	526	17	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	526	18	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	526	19	influenzae	influenzae	NN
cord-296585-yfh5d4io	526	20	:	:	:
cord-296585-yfh5d4io	526	21	from	from	IN
cord-296585-yfh5d4io	526	22	commensal	commensal	NN
cord-296585-yfh5d4io	526	23	to	to	IN
cord-296585-yfh5d4io	526	24	pathogen	pathogen	NN
cord-296585-yfh5d4io	526	25	Update	update	NN
cord-296585-yfh5d4io	526	26	on	on	IN
cord-296585-yfh5d4io	526	27	non	non	JJ
cord-296585-yfh5d4io	526	28	-	-	JJ
cord-296585-yfh5d4io	526	29	typeable	typeable	JJ
cord-296585-yfh5d4io	526	30	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	526	31	influenzaemediated	influenzaemediate	VBN
cord-296585-yfh5d4io	526	32	disease	disease	NN
cord-296585-yfh5d4io	526	33	and	and	CC
cord-296585-yfh5d4io	526	34	vaccine	vaccine	NN
cord-296585-yfh5d4io	526	35	development	development	NN
cord-296585-yfh5d4io	527	1	The	the	DT
cord-296585-yfh5d4io	527	2	evidence	evidence	NN
cord-296585-yfh5d4io	527	3	for	for	IN
cord-296585-yfh5d4io	527	4	non	non	JJ
cord-296585-yfh5d4io	527	5	-	-	JJ
cord-296585-yfh5d4io	527	6	typeable	typeable	JJ
cord-296585-yfh5d4io	527	7	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	527	8	influenzae	influenzae	NN
cord-296585-yfh5d4io	527	9	as	as	IN
cord-296585-yfh5d4io	527	10	a	a	DT
cord-296585-yfh5d4io	527	11	causative	causative	JJ
cord-296585-yfh5d4io	527	12	agent	agent	NN
cord-296585-yfh5d4io	527	13	of	of	IN
cord-296585-yfh5d4io	527	14	childhood	childhood	NN
cord-296585-yfh5d4io	527	15	pneumonia	pneumonia	NN
cord-296585-yfh5d4io	527	16	Bronchiectasis	Bronchiectasis	NNP
cord-296585-yfh5d4io	527	17	in	in	IN
cord-296585-yfh5d4io	527	18	children	child	NNS
cord-296585-yfh5d4io	527	19	:	:	:
cord-296585-yfh5d4io	527	20	current	current	JJ
cord-296585-yfh5d4io	527	21	concepts	concept	NNS
cord-296585-yfh5d4io	527	22	in	in	IN
cord-296585-yfh5d4io	527	23	immunology	immunology	NN
cord-296585-yfh5d4io	527	24	and	and	CC
cord-296585-yfh5d4io	527	25	microbiology	microbiology	NN
cord-296585-yfh5d4io	527	26	.	.	.
cord-296585-yfh5d4io	528	1	Front	Front	NNP
cord-296585-yfh5d4io	528	2	Pediatr	Pediatr	NNP
cord-296585-yfh5d4io	528	3	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	528	4	influenzae	influenzae	NN
cord-296585-yfh5d4io	528	5	in	in	IN
cord-296585-yfh5d4io	528	6	children	child	NNS
cord-296585-yfh5d4io	528	7	with	with	IN
cord-296585-yfh5d4io	528	8	cystic	cystic	JJ
cord-296585-yfh5d4io	528	9	fibrosis	fibrosis	NN
cord-296585-yfh5d4io	528	10	:	:	:
cord-296585-yfh5d4io	528	11	antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	528	12	susceptibility	susceptibility	NN
cord-296585-yfh5d4io	528	13	,	,	,
cord-296585-yfh5d4io	528	14	molecular	molecular	JJ
cord-296585-yfh5d4io	528	15	epidemiology	epidemiology	NN
cord-296585-yfh5d4io	528	16	,	,	,
cord-296585-yfh5d4io	528	17	distribution	distribution	NN
cord-296585-yfh5d4io	528	18	of	of	IN
cord-296585-yfh5d4io	528	19	adhesins	adhesin	NNS
cord-296585-yfh5d4io	528	20	and	and	CC
cord-296585-yfh5d4io	528	21	biofilm	biofilm	NN
cord-296585-yfh5d4io	529	1	formation	formation	NN
cord-296585-yfh5d4io	530	1	The	the	DT
cord-296585-yfh5d4io	530	2	role	role	NN
cord-296585-yfh5d4io	530	3	of	of	IN
cord-296585-yfh5d4io	530	4	infection	infection	NN
cord-296585-yfh5d4io	530	5	in	in	IN
cord-296585-yfh5d4io	530	6	interstitial	interstitial	JJ
cord-296585-yfh5d4io	530	7	lung	lung	NN
cord-296585-yfh5d4io	530	8	diseases	disease	NNS
cord-296585-yfh5d4io	530	9	:	:	:
cord-296585-yfh5d4io	530	10	a	a	DT
cord-296585-yfh5d4io	530	11	review	review	NN
cord-296585-yfh5d4io	530	12	Microbial	microbial	JJ
cord-296585-yfh5d4io	530	13	communities	community	NNS
cord-296585-yfh5d4io	530	14	in	in	IN
cord-296585-yfh5d4io	530	15	the	the	DT
cord-296585-yfh5d4io	530	16	respiratory	respiratory	JJ
cord-296585-yfh5d4io	530	17	tract	tract	NN
cord-296585-yfh5d4io	530	18	of	of	IN
cord-296585-yfh5d4io	530	19	patients	patient	NNS
cord-296585-yfh5d4io	530	20	with	with	IN
cord-296585-yfh5d4io	530	21	interstitial	interstitial	JJ
cord-296585-yfh5d4io	530	22	lung	lung	NN
cord-296585-yfh5d4io	530	23	disease	disease	NN
cord-296585-yfh5d4io	530	24	Infection	Infection	NNP
cord-296585-yfh5d4io	530	25	in	in	IN
cord-296585-yfh5d4io	530	26	the	the	DT
cord-296585-yfh5d4io	530	27	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	530	28	and	and	CC
cord-296585-yfh5d4io	530	29	course	course	NN
cord-296585-yfh5d4io	530	30	of	of	IN
cord-296585-yfh5d4io	530	31	chronic	chronic	JJ
cord-296585-yfh5d4io	530	32	obstructive	obstructive	JJ
cord-296585-yfh5d4io	530	33	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	530	34	disease	disease	NN
cord-296585-yfh5d4io	530	35	Nontypeable	Nontypeable	NNP
cord-296585-yfh5d4io	530	36	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	530	37	influenzae	influenzae	NN
cord-296585-yfh5d4io	530	38	detection	detection	NN
cord-296585-yfh5d4io	530	39	in	in	IN
cord-296585-yfh5d4io	530	40	the	the	DT
cord-296585-yfh5d4io	530	41	lower	low	JJR
cord-296585-yfh5d4io	530	42	airways	airway	NNS
cord-296585-yfh5d4io	530	43	of	of	IN
cord-296585-yfh5d4io	530	44	patients	patient	NNS
cord-296585-yfh5d4io	530	45	with	with	IN
cord-296585-yfh5d4io	530	46	lung	lung	NN
cord-296585-yfh5d4io	530	47	cancer	cancer	NN
cord-296585-yfh5d4io	530	48	and	and	CC
cord-296585-yfh5d4io	530	49	chronic	chronic	JJ
cord-296585-yfh5d4io	530	50	obstructive	obstructive	JJ
cord-296585-yfh5d4io	530	51	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	530	52	disease	disease	NN
cord-296585-yfh5d4io	531	1	The	the	DT
cord-296585-yfh5d4io	531	2	global	global	JJ
cord-296585-yfh5d4io	531	3	burden	burden	NN
cord-296585-yfh5d4io	531	4	of	of	IN
cord-296585-yfh5d4io	531	5	respiratory	respiratory	JJ
cord-296585-yfh5d4io	531	6	disease	disease	NN
cord-296585-yfh5d4io	531	7	Epidemiology	epidemiology	NN
cord-296585-yfh5d4io	531	8	and	and	CC
cord-296585-yfh5d4io	531	9	prevalence	prevalence	NN
cord-296585-yfh5d4io	531	10	of	of	IN
cord-296585-yfh5d4io	531	11	chronic	chronic	JJ
cord-296585-yfh5d4io	531	12	obstructive	obstructive	JJ
cord-296585-yfh5d4io	531	13	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	531	14	disease	disease	NN
cord-296585-yfh5d4io	531	15	Multifaceted	multifacete	VBN
cord-296585-yfh5d4io	531	16	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	531	17	in	in	IN
cord-296585-yfh5d4io	531	18	COPD	COPD	NNP
cord-296585-yfh5d4io	531	19	:	:	:
cord-296585-yfh5d4io	531	20	inflammation	inflammation	NN
cord-296585-yfh5d4io	531	21	,	,	,
cord-296585-yfh5d4io	531	22	immunity	immunity	NN
cord-296585-yfh5d4io	531	23	,	,	,
cord-296585-yfh5d4io	531	24	and	and	CC
cord-296585-yfh5d4io	531	25	tissue	tissue	NN
cord-296585-yfh5d4io	531	26	repair	repair	NN
cord-296585-yfh5d4io	531	27	and	and	CC
cord-296585-yfh5d4io	531	28	destruction	destruction	NN
cord-296585-yfh5d4io	531	29	Inflammation	inflammation	NN
cord-296585-yfh5d4io	531	30	in	in	IN
cord-296585-yfh5d4io	531	31	COPD	COPD	NNP
cord-296585-yfh5d4io	531	32	:	:	:
cord-296585-yfh5d4io	531	33	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	531	34	,	,	,
cord-296585-yfh5d4io	531	35	local	local	JJ
cord-296585-yfh5d4io	531	36	and	and	CC
cord-296585-yfh5d4io	531	37	systemic	systemic	JJ
cord-296585-yfh5d4io	531	38	effects	effect	NNS
cord-296585-yfh5d4io	531	39	Chronic	Chronic	NNP
cord-296585-yfh5d4io	531	40	obstructive	obstructive	JJ
cord-296585-yfh5d4io	531	41	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	531	42	disease	disease	NN
cord-296585-yfh5d4io	531	43	Chronic	Chronic	NNP
cord-296585-yfh5d4io	531	44	obstructive	obstructive	JJ
cord-296585-yfh5d4io	531	45	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	531	46	disease	disease	NN
cord-296585-yfh5d4io	531	47	Complex	complex	JJ
cord-296585-yfh5d4io	531	48	chronic	chronic	JJ
cord-296585-yfh5d4io	531	49	comorbidities	comorbiditie	NNS
cord-296585-yfh5d4io	531	50	of	of	IN
cord-296585-yfh5d4io	531	51	COPD	COPD	NNP
cord-296585-yfh5d4io	531	52	COPD	COPD	NNP
cord-296585-yfh5d4io	531	53	:	:	:
cord-296585-yfh5d4io	531	54	a	a	DT
cord-296585-yfh5d4io	531	55	multifactorial	multifactorial	JJ
cord-296585-yfh5d4io	531	56	systemic	systemic	JJ
cord-296585-yfh5d4io	531	57	disease	disease	NN
cord-296585-yfh5d4io	531	58	Global	global	JJ
cord-296585-yfh5d4io	531	59	burden	burden	NN
cord-296585-yfh5d4io	531	60	of	of	IN
cord-296585-yfh5d4io	531	61	COPD	COPD	NNP
cord-296585-yfh5d4io	531	62	:	:	:
cord-296585-yfh5d4io	531	63	risk	risk	NN
cord-296585-yfh5d4io	531	64	factors	factor	NNS
cord-296585-yfh5d4io	531	65	,	,	,
cord-296585-yfh5d4io	531	66	prevalence	prevalence	NN
cord-296585-yfh5d4io	531	67	,	,	,
cord-296585-yfh5d4io	531	68	and	and	CC
cord-296585-yfh5d4io	531	69	future	future	JJ
cord-296585-yfh5d4io	531	70	trends	trend	NNS
cord-296585-yfh5d4io	532	1	Tobacco	tobacco	NN
cord-296585-yfh5d4io	532	2	smoke	smoke	NN
cord-296585-yfh5d4io	532	3	induces	induce	VBZ
cord-296585-yfh5d4io	532	4	and	and	CC
cord-296585-yfh5d4io	532	5	alters	alter	VBZ
cord-296585-yfh5d4io	532	6	immune	immune	JJ
cord-296585-yfh5d4io	532	7	responses	response	NNS
cord-296585-yfh5d4io	532	8	in	in	IN
cord-296585-yfh5d4io	532	9	the	the	DT
cord-296585-yfh5d4io	532	10	lung	lung	NN
cord-296585-yfh5d4io	532	11	triggering	trigger	VBG
cord-296585-yfh5d4io	532	12	inflammation	inflammation	NN
cord-296585-yfh5d4io	532	13	,	,	,
cord-296585-yfh5d4io	532	14	allergy	allergy	NN
cord-296585-yfh5d4io	532	15	,	,	,
cord-296585-yfh5d4io	532	16	asthma	asthma	NN
cord-296585-yfh5d4io	532	17	and	and	CC
cord-296585-yfh5d4io	532	18	other	other	JJ
cord-296585-yfh5d4io	532	19	lung	lung	NN
cord-296585-yfh5d4io	532	20	diseases	disease	NNS
cord-296585-yfh5d4io	532	21	:	:	:
cord-296585-yfh5d4io	532	22	a	a	DT
cord-296585-yfh5d4io	532	23	mechanistic	mechanistic	JJ
cord-296585-yfh5d4io	532	24	review	review	NN
cord-296585-yfh5d4io	532	25	Bronchial	bronchial	JJ
cord-296585-yfh5d4io	532	26	asthma	asthma	NN
cord-296585-yfh5d4io	532	27	:	:	:
cord-296585-yfh5d4io	532	28	progress	progress	VB
cord-296585-yfh5d4io	532	29	in	in	IN
cord-296585-yfh5d4io	532	30	diagnosis	diagnosis	NN
cord-296585-yfh5d4io	532	31	and	and	CC
cord-296585-yfh5d4io	532	32	treatments	treatment	NNS
cord-296585-yfh5d4io	532	33	.	.	.
cord-296585-yfh5d4io	533	1	Topics	topic	NNS
cord-296585-yfh5d4io	533	2	:	:	:
cord-296585-yfh5d4io	533	3	II	II	NNP
cord-296585-yfh5d4io	533	4	.	.	.
cord-296585-yfh5d4io	534	1	Pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	534	2	and	and	CC
cord-296585-yfh5d4io	534	3	pathophysiology	pathophysiology	NN
cord-296585-yfh5d4io	534	4	;	;	:
cord-296585-yfh5d4io	534	5	1	1	CD
cord-296585-yfh5d4io	534	6	.	.	.
cord-296585-yfh5d4io	535	1	The	the	DT
cord-296585-yfh5d4io	535	2	Dutch	dutch	JJ
cord-296585-yfh5d4io	535	3	hypothesis	hypothesis	NN
cord-296585-yfh5d4io	535	4	and	and	CC
cord-296585-yfh5d4io	535	5	British	british	JJ
cord-296585-yfh5d4io	535	6	hypothesis	hypothesis	NN
cord-296585-yfh5d4io	535	7	Alpha-1	Alpha-1	NNP
cord-296585-yfh5d4io	535	8	antitrypsin	antitrypsin	NN
cord-296585-yfh5d4io	535	9	deficiency	deficiency	NN
cord-296585-yfh5d4io	536	1	A	a	DT
cord-296585-yfh5d4io	536	2	novel	novel	JJ
cord-296585-yfh5d4io	536	3	elastin	elastin	NN
cord-296585-yfh5d4io	536	4	gene	gene	NN
cord-296585-yfh5d4io	536	5	mutation	mutation	NN
cord-296585-yfh5d4io	536	6	resulting	result	VBG
cord-296585-yfh5d4io	536	7	in	in	IN
cord-296585-yfh5d4io	536	8	an	an	DT
cord-296585-yfh5d4io	536	9	autosomal	autosomal	JJ
cord-296585-yfh5d4io	536	10	dominant	dominant	JJ
cord-296585-yfh5d4io	536	11	form	form	NN
cord-296585-yfh5d4io	536	12	of	of	IN
cord-296585-yfh5d4io	536	13	cutis	cutis	NN
cord-296585-yfh5d4io	536	14	laxa	laxa	NNP
cord-296585-yfh5d4io	536	15	Risk	Risk	NNP
cord-296585-yfh5d4io	536	16	loci	locus	NNS
cord-296585-yfh5d4io	536	17	for	for	IN
cord-296585-yfh5d4io	536	18	chronic	chronic	JJ
cord-296585-yfh5d4io	536	19	obstructive	obstructive	JJ
cord-296585-yfh5d4io	536	20	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	536	21	disease	disease	NN
cord-296585-yfh5d4io	536	22	:	:	:
cord-296585-yfh5d4io	536	23	a	a	DT
cord-296585-yfh5d4io	536	24	genome	genome	NN
cord-296585-yfh5d4io	536	25	-	-	HYPH
cord-296585-yfh5d4io	536	26	wide	wide	JJ
cord-296585-yfh5d4io	536	27	association	association	NN
cord-296585-yfh5d4io	536	28	study	study	NN
cord-296585-yfh5d4io	536	29	and	and	CC
cord-296585-yfh5d4io	536	30	meta	meta	NNP
cord-296585-yfh5d4io	536	31	-	-	HYPH
cord-296585-yfh5d4io	536	32	analysis	analysis	NNP
cord-296585-yfh5d4io	536	33	Association	Association	NNP
cord-296585-yfh5d4io	536	34	between	between	IN
cord-296585-yfh5d4io	536	35	the	the	DT
cord-296585-yfh5d4io	536	36	length	length	NN
cord-296585-yfh5d4io	536	37	of	of	IN
cord-296585-yfh5d4io	536	38	the	the	DT
cord-296585-yfh5d4io	536	39	MUC8-minisatellite	MUC8-minisatellite	NNP
cord-296585-yfh5d4io	536	40	5	5	CD
cord-296585-yfh5d4io	536	41	region	region	NN
cord-296585-yfh5d4io	536	42	and	and	CC
cord-296585-yfh5d4io	536	43	susceptibility	susceptibility	NN
cord-296585-yfh5d4io	536	44	to	to	IN
cord-296585-yfh5d4io	536	45	chronic	chronic	JJ
cord-296585-yfh5d4io	536	46	obstructive	obstructive	JJ
cord-296585-yfh5d4io	536	47	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	536	48	disease	disease	NN
cord-296585-yfh5d4io	536	49	(	(	-LRB-
cord-296585-yfh5d4io	536	50	COPD	COPD	NNP
cord-296585-yfh5d4io	536	51	)	)	-RRB-
cord-296585-yfh5d4io	537	1	Human	human	JJ
cord-296585-yfh5d4io	537	2	airway	airway	NN
cord-296585-yfh5d4io	537	3	branch	branch	NN
cord-296585-yfh5d4io	537	4	variation	variation	NN
cord-296585-yfh5d4io	537	5	and	and	CC
cord-296585-yfh5d4io	537	6	chronic	chronic	JJ
cord-296585-yfh5d4io	537	7	obstructive	obstructive	JJ
cord-296585-yfh5d4io	537	8	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	537	9	disease	disease	NN
cord-296585-yfh5d4io	537	10	Exomewide	Exomewide	NNP
cord-296585-yfh5d4io	537	11	analysis	analysis	NN
cord-296585-yfh5d4io	537	12	of	of	IN
cord-296585-yfh5d4io	537	13	rare	rare	JJ
cord-296585-yfh5d4io	537	14	coding	coding	NN
cord-296585-yfh5d4io	537	15	variation	variation	NN
cord-296585-yfh5d4io	537	16	identifies	identify	VBZ
cord-296585-yfh5d4io	537	17	novel	novel	JJ
cord-296585-yfh5d4io	537	18	associations	association	NNS
cord-296585-yfh5d4io	537	19	with	with	IN
cord-296585-yfh5d4io	537	20	COPD	COPD	NNP
cord-296585-yfh5d4io	537	21	and	and	CC
cord-296585-yfh5d4io	537	22	airflow	airflow	NN
cord-296585-yfh5d4io	537	23	limitation	limitation	NN
cord-296585-yfh5d4io	537	24	in	in	IN
cord-296585-yfh5d4io	537	25	MOCS3	MOCS3	NNP
cord-296585-yfh5d4io	537	26	,	,	,
cord-296585-yfh5d4io	537	27	IFIT3	ifit3	CC
cord-296585-yfh5d4io	537	28	and	and	CC
cord-296585-yfh5d4io	538	1	SERPINA12	SERPINA12	NFP
cord-296585-yfh5d4io	538	2	Exposure	exposure	NN
cord-296585-yfh5d4io	538	3	to	to	IN
cord-296585-yfh5d4io	538	4	cigarette	cigarette	NN
cord-296585-yfh5d4io	538	5	smoke	smoke	NN
cord-296585-yfh5d4io	538	6	extract	extract	NN
cord-296585-yfh5d4io	538	7	and	and	CC
cord-296585-yfh5d4io	538	8	lipopolysaccharide	lipopolysaccharide	NN
cord-296585-yfh5d4io	538	9	modifies	modify	VBZ
cord-296585-yfh5d4io	538	10	cytoskeleton	cytoskeleton	NN
cord-296585-yfh5d4io	538	11	organization	organization	NN
cord-296585-yfh5d4io	538	12	in	in	IN
cord-296585-yfh5d4io	538	13	bronchial	bronchial	JJ
cord-296585-yfh5d4io	538	14	epithelial	epithelial	JJ
cord-296585-yfh5d4io	538	15	cells	cell	NNS
cord-296585-yfh5d4io	538	16	Airway	airway	JJ
cord-296585-yfh5d4io	538	17	epithelial	epithelial	JJ
cord-296585-yfh5d4io	538	18	barrier	barrier	NN
cord-296585-yfh5d4io	538	19	dysfunction	dysfunction	NN
cord-296585-yfh5d4io	538	20	in	in	IN
cord-296585-yfh5d4io	538	21	chronic	chronic	JJ
cord-296585-yfh5d4io	538	22	obstructive	obstructive	JJ
cord-296585-yfh5d4io	538	23	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	538	24	disease	disease	NN
cord-296585-yfh5d4io	538	25	:	:	:
cord-296585-yfh5d4io	538	26	role	role	NN
cord-296585-yfh5d4io	538	27	decarboxylase	decarboxylase	NNP
cord-296585-yfh5d4io	538	28	67	67	CD
cord-296585-yfh5d4io	538	29	promoter	promoter	NN
cord-296585-yfh5d4io	538	30	methylation	methylation	NN
cord-296585-yfh5d4io	538	31	in	in	IN
cord-296585-yfh5d4io	538	32	GABAergic	GABAergic	NNP
cord-296585-yfh5d4io	538	33	interneurons	interneuron	NNS
cord-296585-yfh5d4io	538	34	Nicotinic	nicotinic	JJ
cord-296585-yfh5d4io	538	35	acetylcholine	acetylcholine	NN
cord-296585-yfh5d4io	538	36	receptor	receptor	NN
cord-296585-yfh5d4io	538	37	-	-	HYPH
cord-296585-yfh5d4io	538	38	mediated	mediate	VBN
cord-296585-yfh5d4io	538	39	calcium	calcium	NN
cord-296585-yfh5d4io	538	40	signaling	signal	VBG
cord-296585-yfh5d4io	538	41	in	in	IN
cord-296585-yfh5d4io	538	42	the	the	DT
cord-296585-yfh5d4io	538	43	nervous	nervous	JJ
cord-296585-yfh5d4io	538	44	system	system	NN
cord-296585-yfh5d4io	539	1	Nicotine	nicotine	NN
cord-296585-yfh5d4io	539	2	addiction	addiction	NN
cord-296585-yfh5d4io	539	3	Cigarette	cigarette	NN
cord-296585-yfh5d4io	539	4	smoke	smoke	NN
cord-296585-yfh5d4io	539	5	reversibly	reversibly	RB
cord-296585-yfh5d4io	539	6	activates	activate	VBZ
cord-296585-yfh5d4io	539	7	hypoxia	hypoxia	NN
cord-296585-yfh5d4io	539	8	-	-	HYPH
cord-296585-yfh5d4io	539	9	inducible	inducible	JJ
cord-296585-yfh5d4io	539	10	factor	factor	NN
cord-296585-yfh5d4io	539	11	1	1	CD
cord-296585-yfh5d4io	539	12	in	in	IN
cord-296585-yfh5d4io	539	13	a	a	DT
cord-296585-yfh5d4io	539	14	reactive	reactive	JJ
cord-296585-yfh5d4io	539	15	oxygen	oxygen	NN
cord-296585-yfh5d4io	539	16	species	specie	NNS
cord-296585-yfh5d4io	539	17	-	-	HYPH
cord-296585-yfh5d4io	539	18	dependent	dependent	JJ
cord-296585-yfh5d4io	539	19	manner	manner	NN
cord-296585-yfh5d4io	539	20	Decreased	decrease	VBD
cord-296585-yfh5d4io	540	1	histone	histone	NN
cord-296585-yfh5d4io	540	2	deacetylase	deacetylase	NNP
cord-296585-yfh5d4io	540	3	2	2	CD
cord-296585-yfh5d4io	540	4	impairs	impair	VBZ
cord-296585-yfh5d4io	540	5	Nrf2	Nrf2	NNP
cord-296585-yfh5d4io	540	6	activation	activation	NN
cord-296585-yfh5d4io	540	7	by	by	IN
cord-296585-yfh5d4io	540	8	oxidative	oxidative	JJ
cord-296585-yfh5d4io	540	9	stress	stress	NN
cord-296585-yfh5d4io	540	10	Cigarette	Cigarette	NNP
cord-296585-yfh5d4io	540	11	smoke	smoke	NN
cord-296585-yfh5d4io	540	12	extract	extract	NN
cord-296585-yfh5d4io	540	13	increases	increase	VBZ
cord-296585-yfh5d4io	540	14	vascular	vascular	JJ
cord-296585-yfh5d4io	540	15	endothelial	endothelial	JJ
cord-296585-yfh5d4io	540	16	growth	growth	NN
cord-296585-yfh5d4io	540	17	factor	factor	NN
cord-296585-yfh5d4io	540	18	production	production	NN
cord-296585-yfh5d4io	540	19	via	via	IN
cord-296585-yfh5d4io	540	20	TLR4	TLR4	NNP
cord-296585-yfh5d4io	540	21	/	/	SYM
cord-296585-yfh5d4io	540	22	ROS	ROS	NNP
cord-296585-yfh5d4io	540	23	/	/	SYM
cord-296585-yfh5d4io	540	24	MAPKs	MAPKs	NNP
cord-296585-yfh5d4io	540	25	/	/	SYM
cord-296585-yfh5d4io	540	26	NF	NF	NNP
cord-296585-yfh5d4io	540	27	-	-	HYPH
cord-296585-yfh5d4io	540	28	kappaB	kappaB	NNP
cord-296585-yfh5d4io	540	29	pathway	pathway	NN
cord-296585-yfh5d4io	540	30	in	in	IN
cord-296585-yfh5d4io	540	31	nasal	nasal	JJ
cord-296585-yfh5d4io	540	32	fibroblast	fibroblast	NN
cord-296585-yfh5d4io	540	33	Receptor	receptor	NN
cord-296585-yfh5d4io	540	34	for	for	IN
cord-296585-yfh5d4io	540	35	advanced	advanced	JJ
cord-296585-yfh5d4io	540	36	glycation	glycation	NN
cord-296585-yfh5d4io	540	37	end	end	NN
cord-296585-yfh5d4io	540	38	-	-	HYPH
cord-296585-yfh5d4io	540	39	products	product	NNS
cord-296585-yfh5d4io	540	40	signals	signal	NNS
cord-296585-yfh5d4io	540	41	through	through	IN
cord-296585-yfh5d4io	540	42	Ras	Ras	NNP
cord-296585-yfh5d4io	540	43	during	during	IN
cord-296585-yfh5d4io	540	44	tobacco	tobacco	NN
cord-296585-yfh5d4io	540	45	smoke	smoke	NN
cord-296585-yfh5d4io	540	46	-	-	HYPH
cord-296585-yfh5d4io	540	47	induced	induce	VBN
cord-296585-yfh5d4io	540	48	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	540	49	inflammation	inflammation	NN
cord-296585-yfh5d4io	540	50	Oxidation	oxidation	NN
cord-296585-yfh5d4io	540	51	of	of	IN
cord-296585-yfh5d4io	540	52	Z	Z	NNP
cord-296585-yfh5d4io	540	53	alpha1-antitrypsin	alpha1-antitrypsin	VBN
cord-296585-yfh5d4io	540	54	by	by	IN
cord-296585-yfh5d4io	540	55	cigarette	cigarette	NN
cord-296585-yfh5d4io	540	56	smoke	smoke	NN
cord-296585-yfh5d4io	541	1	induces	induce	VBZ
cord-296585-yfh5d4io	541	2	polymerization	polymerization	NN
cord-296585-yfh5d4io	541	3	:	:	:
cord-296585-yfh5d4io	542	1	a	a	DT
cord-296585-yfh5d4io	542	2	novel	novel	JJ
cord-296585-yfh5d4io	542	3	mechanism	mechanism	NN
cord-296585-yfh5d4io	542	4	of	of	IN
cord-296585-yfh5d4io	542	5	early	early	JJ
cord-296585-yfh5d4io	542	6	-	-	HYPH
cord-296585-yfh5d4io	542	7	onset	onset	NN
cord-296585-yfh5d4io	542	8	emphysema	emphysema	NN
cord-296585-yfh5d4io	542	9	Role	role	NN
cord-296585-yfh5d4io	542	10	of	of	IN
cord-296585-yfh5d4io	542	11	proteases	protease	NNS
cord-296585-yfh5d4io	542	12	in	in	IN
cord-296585-yfh5d4io	542	13	chronic	chronic	JJ
cord-296585-yfh5d4io	542	14	obstructive	obstructive	JJ
cord-296585-yfh5d4io	542	15	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	542	16	disease	disease	NN
cord-296585-yfh5d4io	542	17	Cigarette	Cigarette	NNP
cord-296585-yfh5d4io	542	18	smoke	smoke	NN
cord-296585-yfh5d4io	542	19	induces	induce	VBZ
cord-296585-yfh5d4io	542	20	proinflammatory	proinflammatory	JJ
cord-296585-yfh5d4io	542	21	cytokine	cytokine	NN
cord-296585-yfh5d4io	542	22	release	release	NN
cord-296585-yfh5d4io	542	23	by	by	IN
cord-296585-yfh5d4io	542	24	activation	activation	NN
cord-296585-yfh5d4io	542	25	of	of	IN
cord-296585-yfh5d4io	542	26	NF	NF	NNP
cord-296585-yfh5d4io	542	27	-	-	HYPH
cord-296585-yfh5d4io	542	28	kappaB	kappaB	NNP
cord-296585-yfh5d4io	542	29	and	and	CC
cord-296585-yfh5d4io	542	30	posttranslational	posttranslational	JJ
cord-296585-yfh5d4io	542	31	modifications	modification	NNS
cord-296585-yfh5d4io	542	32	of	of	IN
cord-296585-yfh5d4io	542	33	histone	histone	NN
cord-296585-yfh5d4io	542	34	deacetylase	deacetylase	NN
cord-296585-yfh5d4io	542	35	in	in	IN
cord-296585-yfh5d4io	542	36	macrophages	macrophage	NNS
cord-296585-yfh5d4io	542	37	Cigarette	cigarette	NN
cord-296585-yfh5d4io	542	38	smoke	smoke	NN
cord-296585-yfh5d4io	542	39	and	and	CC
cord-296585-yfh5d4io	542	40	its	-PRON-	PRP$
cord-296585-yfh5d4io	542	41	component	component	NN
cord-296585-yfh5d4io	542	42	acrolein	acrolein	NN
cord-296585-yfh5d4io	543	1	augment	augment	VB
cord-296585-yfh5d4io	543	2	IL	IL	NNP
cord-296585-yfh5d4io	543	3	/CXCL8	/CXCL8	.
cord-296585-yfh5d4io	543	4	mRNA	mrna	NN
cord-296585-yfh5d4io	543	5	stability	stability	NN
cord-296585-yfh5d4io	543	6	via	via	IN
cord-296585-yfh5d4io	543	7	p38	p38	NNP
cord-296585-yfh5d4io	543	8	MAPK	MAPK	NNP
cord-296585-yfh5d4io	543	9	/	/	SYM
cord-296585-yfh5d4io	543	10	MK2	MK2	NNP
cord-296585-yfh5d4io	543	11	signaling	signal	VBG
cord-296585-yfh5d4io	543	12	in	in	IN
cord-296585-yfh5d4io	543	13	human	human	JJ
cord-296585-yfh5d4io	543	14	pulmonary	pulmonary	NN
cord-296585-yfh5d4io	543	15	cells	cell	NNS
cord-296585-yfh5d4io	543	16	Mechanisms	Mechanisms	NNPS
cord-296585-yfh5d4io	543	17	underlying	underlie	VBG
cord-296585-yfh5d4io	543	18	cigarette	cigarette	NN
cord-296585-yfh5d4io	543	19	smoke	smoke	NN
cord-296585-yfh5d4io	543	20	-	-	HYPH
cord-296585-yfh5d4io	543	21	induced	induce	VBN
cord-296585-yfh5d4io	543	22	NF	nf	NN
cord-296585-yfh5d4io	543	23	-	-	HYPH
cord-296585-yfh5d4io	543	24	kappaB	kappaB	NNP
cord-296585-yfh5d4io	543	25	activation	activation	NN
cord-296585-yfh5d4io	543	26	in	in	IN
cord-296585-yfh5d4io	543	27	human	human	JJ
cord-296585-yfh5d4io	543	28	lymphocytes	lymphocyte	NNS
cord-296585-yfh5d4io	543	29	:	:	:
cord-296585-yfh5d4io	544	1	the	the	DT
cord-296585-yfh5d4io	544	2	role	role	NN
cord-296585-yfh5d4io	544	3	of	of	IN
cord-296585-yfh5d4io	544	4	reactive	reactive	JJ
cord-296585-yfh5d4io	544	5	nitrogen	nitrogen	NN
cord-296585-yfh5d4io	544	6	species	specie	NNS
cord-296585-yfh5d4io	544	7	Dendritic	dendritic	JJ
cord-296585-yfh5d4io	544	8	cells	cell	NNS
cord-296585-yfh5d4io	544	9	in	in	IN
cord-296585-yfh5d4io	544	10	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	544	11	of	of	IN
cord-296585-yfh5d4io	544	12	COPD	COPD	NNP
cord-296585-yfh5d4io	544	13	Immunology	Immunology	NNP
cord-296585-yfh5d4io	544	14	of	of	IN
cord-296585-yfh5d4io	544	15	asthma	asthma	NN
cord-296585-yfh5d4io	544	16	and	and	CC
cord-296585-yfh5d4io	544	17	chronic	chronic	JJ
cord-296585-yfh5d4io	544	18	obstructive	obstructive	JJ
cord-296585-yfh5d4io	544	19	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	544	20	disease	disease	NN
cord-296585-yfh5d4io	545	1	New	new	JJ
cord-296585-yfh5d4io	545	2	insights	insight	NNS
cord-296585-yfh5d4io	545	3	into	into	IN
cord-296585-yfh5d4io	545	4	the	the	DT
cord-296585-yfh5d4io	545	5	immunology	immunology	NN
cord-296585-yfh5d4io	545	6	of	of	IN
cord-296585-yfh5d4io	545	7	chronic	chronic	JJ
cord-296585-yfh5d4io	545	8	obstructive	obstructive	JJ
cord-296585-yfh5d4io	545	9	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	545	10	disease	disease	NN
cord-296585-yfh5d4io	545	11	Immune	Immune	NNP
cord-296585-yfh5d4io	545	12	dysfunction	dysfunction	NN
cord-296585-yfh5d4io	545	13	in	in	IN
cord-296585-yfh5d4io	545	14	patients	patient	NNS
cord-296585-yfh5d4io	545	15	with	with	IN
cord-296585-yfh5d4io	545	16	chronic	chronic	JJ
cord-296585-yfh5d4io	545	17	obstructive	obstructive	JJ
cord-296585-yfh5d4io	545	18	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	545	19	disease	disease	NN
cord-296585-yfh5d4io	545	20	Murine	Murine	NNP
cord-296585-yfh5d4io	545	21	TLR4	TLR4	NNP
cord-296585-yfh5d4io	545	22	is	be	VBZ
cord-296585-yfh5d4io	545	23	implicated	implicate	VBN
cord-296585-yfh5d4io	545	24	in	in	IN
cord-296585-yfh5d4io	545	25	cigarette	cigarette	NN
cord-296585-yfh5d4io	545	26	smoke	smoke	NN
cord-296585-yfh5d4io	545	27	-	-	HYPH
cord-296585-yfh5d4io	545	28	induced	induce	VBN
cord-296585-yfh5d4io	545	29	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	545	30	inflammation	inflammation	NN
cord-296585-yfh5d4io	545	31	TLR2	TLR2	NNP
cord-296585-yfh5d4io	545	32	and	and	CC
cord-296585-yfh5d4io	545	33	TLR4	TLR4	NNP
cord-296585-yfh5d4io	545	34	mediated	mediate	VBD
cord-296585-yfh5d4io	545	35	host	host	NN
cord-296585-yfh5d4io	545	36	immune	immune	JJ
cord-296585-yfh5d4io	545	37	responses	response	NNS
cord-296585-yfh5d4io	545	38	in	in	IN
cord-296585-yfh5d4io	545	39	major	major	JJ
cord-296585-yfh5d4io	545	40	infectious	infectious	JJ
cord-296585-yfh5d4io	545	41	diseases	disease	NNS
cord-296585-yfh5d4io	545	42	:	:	:
cord-296585-yfh5d4io	545	43	a	a	DT
cord-296585-yfh5d4io	545	44	review	review	NN
cord-296585-yfh5d4io	545	45	Barrier	Barrier	NNP
cord-296585-yfh5d4io	545	46	epithelial	epithelial	JJ
cord-296585-yfh5d4io	545	47	cells	cell	NNS
cord-296585-yfh5d4io	545	48	and	and	CC
cord-296585-yfh5d4io	545	49	the	the	DT
cord-296585-yfh5d4io	545	50	control	control	NN
cord-296585-yfh5d4io	545	51	of	of	IN
cord-296585-yfh5d4io	545	52	type	type	NN
cord-296585-yfh5d4io	545	53	2	2	CD
cord-296585-yfh5d4io	545	54	immunity	immunity	NN
cord-296585-yfh5d4io	545	55	Cigarette	cigarette	NN
cord-296585-yfh5d4io	545	56	smoking	smoking	NN
cord-296585-yfh5d4io	545	57	and	and	CC
cord-296585-yfh5d4io	545	58	inflammation	inflammation	NN
cord-296585-yfh5d4io	545	59	:	:	:
cord-296585-yfh5d4io	546	1	cellular	cellular	JJ
cord-296585-yfh5d4io	546	2	and	and	CC
cord-296585-yfh5d4io	546	3	molecular	molecular	JJ
cord-296585-yfh5d4io	546	4	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	546	5	Cigarette	cigarette	NN
cord-296585-yfh5d4io	546	6	smoke	smoke	NN
cord-296585-yfh5d4io	546	7	induces	induce	VBZ
cord-296585-yfh5d4io	546	8	the	the	DT
cord-296585-yfh5d4io	546	9	release	release	NN
cord-296585-yfh5d4io	546	10	of	of	IN
cord-296585-yfh5d4io	546	11	CXCL-8	CXCL-8	NNPS
cord-296585-yfh5d4io	546	12	from	from	IN
cord-296585-yfh5d4io	546	13	human	human	JJ
cord-296585-yfh5d4io	546	14	bronchial	bronchial	JJ
cord-296585-yfh5d4io	546	15	epithelial	epithelial	JJ
cord-296585-yfh5d4io	546	16	cells	cell	NNS
cord-296585-yfh5d4io	546	17	via	via	IN
cord-296585-yfh5d4io	546	18	TLRs	tlr	NNS
cord-296585-yfh5d4io	546	19	and	and	CC
cord-296585-yfh5d4io	546	20	induction	induction	NN
cord-296585-yfh5d4io	546	21	of	of	IN
cord-296585-yfh5d4io	546	22	the	the	DT
cord-296585-yfh5d4io	546	23	inflammasome	inflammasome	NNP
cord-296585-yfh5d4io	546	24	Long	long	JJ
cord-296585-yfh5d4io	546	25	-	-	HYPH
cord-296585-yfh5d4io	546	26	term	term	NN
cord-296585-yfh5d4io	546	27	IL-33-producing	il-33-produce	VBG
cord-296585-yfh5d4io	546	28	epithelial	epithelial	JJ
cord-296585-yfh5d4io	546	29	progenitor	progenitor	NN
cord-296585-yfh5d4io	546	30	cells	cell	NNS
cord-296585-yfh5d4io	546	31	in	in	IN
cord-296585-yfh5d4io	546	32	chronic	chronic	JJ
cord-296585-yfh5d4io	546	33	obstructive	obstructive	JJ
cord-296585-yfh5d4io	546	34	lung	lung	NN
cord-296585-yfh5d4io	546	35	disease	disease	NN
cord-296585-yfh5d4io	546	36	Mediators	Mediators	NNPS
cord-296585-yfh5d4io	546	37	of	of	IN
cord-296585-yfh5d4io	546	38	chronic	chronic	JJ
cord-296585-yfh5d4io	546	39	obstructive	obstructive	JJ
cord-296585-yfh5d4io	546	40	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	546	41	disease	disease	NN
cord-296585-yfh5d4io	547	1	Alveolar	alveolar	JJ
cord-296585-yfh5d4io	547	2	macrophage	macrophage	NN
cord-296585-yfh5d4io	547	3	-	-	HYPH
cord-296585-yfh5d4io	547	4	mediated	mediate	VBN
cord-296585-yfh5d4io	547	5	elastolysis	elastolysis	NN
cord-296585-yfh5d4io	547	6	:	:	:
cord-296585-yfh5d4io	547	7	roles	role	NNS
cord-296585-yfh5d4io	547	8	of	of	IN
cord-296585-yfh5d4io	547	9	matrix	matrix	NN
cord-296585-yfh5d4io	547	10	metalloproteinases	metalloproteinase	NNS
cord-296585-yfh5d4io	547	11	,	,	,
cord-296585-yfh5d4io	547	12	cysteine	cysteine	NN
cord-296585-yfh5d4io	547	13	,	,	,
cord-296585-yfh5d4io	547	14	and	and	CC
cord-296585-yfh5d4io	547	15	serine	serine	NN
cord-296585-yfh5d4io	547	16	proteases	protease	NNS
cord-296585-yfh5d4io	548	1	Impaired	impaired	JJ
cord-296585-yfh5d4io	548	2	inhibition	inhibition	NN
cord-296585-yfh5d4io	548	3	by	by	IN
cord-296585-yfh5d4io	548	4	dexamethasone	dexamethasone	NN
cord-296585-yfh5d4io	548	5	of	of	IN
cord-296585-yfh5d4io	548	6	cytokine	cytokine	NN
cord-296585-yfh5d4io	548	7	release	release	NN
cord-296585-yfh5d4io	548	8	by	by	IN
cord-296585-yfh5d4io	548	9	alveolar	alveolar	JJ
cord-296585-yfh5d4io	548	10	macrophages	macrophage	NNS
cord-296585-yfh5d4io	548	11	from	from	IN
cord-296585-yfh5d4io	548	12	patients	patient	NNS
cord-296585-yfh5d4io	548	13	with	with	IN
cord-296585-yfh5d4io	548	14	chronic	chronic	JJ
cord-296585-yfh5d4io	548	15	obstructive	obstructive	JJ
cord-296585-yfh5d4io	548	16	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	548	17	disease	disease	NN
cord-296585-yfh5d4io	548	18	Increased	increase	VBN
cord-296585-yfh5d4io	548	19	levels	level	NNS
cord-296585-yfh5d4io	548	20	of	of	IN
cord-296585-yfh5d4io	548	21	the	the	DT
cord-296585-yfh5d4io	548	22	chemokines	chemokine	NNS
cord-296585-yfh5d4io	548	23	GROalpha	GROalpha	NNP
cord-296585-yfh5d4io	548	24	and	and	CC
cord-296585-yfh5d4io	548	25	MCP-1	MCP-1	NNP
cord-296585-yfh5d4io	548	26	in	in	IN
cord-296585-yfh5d4io	548	27	sputum	sputum	NN
cord-296585-yfh5d4io	548	28	samples	sample	NNS
cord-296585-yfh5d4io	548	29	from	from	IN
cord-296585-yfh5d4io	548	30	patients	patient	NNS
cord-296585-yfh5d4io	548	31	with	with	IN
cord-296585-yfh5d4io	548	32	COPD	COPD	NNP
cord-296585-yfh5d4io	549	1	The	the	DT
cord-296585-yfh5d4io	549	2	nature	nature	NN
cord-296585-yfh5d4io	549	3	of	of	IN
cord-296585-yfh5d4io	549	4	small	small	JJ
cord-296585-yfh5d4io	549	5	-	-	HYPH
cord-296585-yfh5d4io	549	6	airway	airway	NN
cord-296585-yfh5d4io	549	7	obstruction	obstruction	NN
cord-296585-yfh5d4io	549	8	in	in	IN
cord-296585-yfh5d4io	549	9	chronic	chronic	JJ
cord-296585-yfh5d4io	549	10	obstructive	obstructive	JJ
cord-296585-yfh5d4io	549	11	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	549	12	disease	disease	NN
cord-296585-yfh5d4io	549	13	Severity	severity	NN
cord-296585-yfh5d4io	549	14	of	of	IN
cord-296585-yfh5d4io	549	15	airflow	airflow	NN
cord-296585-yfh5d4io	549	16	limitation	limitation	NN
cord-296585-yfh5d4io	549	17	is	be	VBZ
cord-296585-yfh5d4io	549	18	associated	associate	VBN
cord-296585-yfh5d4io	549	19	with	with	IN
cord-296585-yfh5d4io	549	20	severity	severity	NN
cord-296585-yfh5d4io	549	21	of	of	IN
cord-296585-yfh5d4io	549	22	airway	airway	JJ
cord-296585-yfh5d4io	549	23	inflammation	inflammation	NN
cord-296585-yfh5d4io	549	24	in	in	IN
cord-296585-yfh5d4io	549	25	smokers	smoker	NNS
cord-296585-yfh5d4io	549	26	Advanced	advanced	JJ
cord-296585-yfh5d4io	549	27	role	role	NN
cord-296585-yfh5d4io	549	28	of	of	IN
cord-296585-yfh5d4io	549	29	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	549	30	in	in	IN
cord-296585-yfh5d4io	549	31	common	common	JJ
cord-296585-yfh5d4io	549	32	respiratory	respiratory	JJ
cord-296585-yfh5d4io	549	33	diseases	disease	NNS
cord-296585-yfh5d4io	549	34	Upregulation	Upregulation	NNP
cord-296585-yfh5d4io	549	35	of	of	IN
cord-296585-yfh5d4io	549	36	adhesion	adhesion	NN
cord-296585-yfh5d4io	549	37	molecules	molecule	NNS
cord-296585-yfh5d4io	549	38	in	in	IN
cord-296585-yfh5d4io	549	39	the	the	DT
cord-296585-yfh5d4io	549	40	bronchial	bronchial	JJ
cord-296585-yfh5d4io	549	41	mucosa	mucosa	NN
cord-296585-yfh5d4io	549	42	of	of	IN
cord-296585-yfh5d4io	549	43	subjects	subject	NNS
cord-296585-yfh5d4io	549	44	with	with	IN
cord-296585-yfh5d4io	549	45	chronic	chronic	JJ
cord-296585-yfh5d4io	549	46	obstructive	obstructive	JJ
cord-296585-yfh5d4io	549	47	bronchitis	bronchitis	NN
cord-296585-yfh5d4io	550	1	The	the	DT
cord-296585-yfh5d4io	550	2	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	550	3	in	in	IN
cord-296585-yfh5d4io	550	4	chronic	chronic	JJ
cord-296585-yfh5d4io	550	5	obstructive	obstructive	JJ
cord-296585-yfh5d4io	550	6	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	550	7	disease	disease	NN
cord-296585-yfh5d4io	550	8	Increased	increase	VBD
cord-296585-yfh5d4io	550	9	metabolic	metabolic	JJ
cord-296585-yfh5d4io	550	10	activity	activity	NN
cord-296585-yfh5d4io	550	11	of	of	IN
cord-296585-yfh5d4io	550	12	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	550	13	in	in	IN
cord-296585-yfh5d4io	550	14	patients	patient	NNS
cord-296585-yfh5d4io	550	15	with	with	IN
cord-296585-yfh5d4io	550	16	chronic	chronic	JJ
cord-296585-yfh5d4io	550	17	obstructive	obstructive	JJ
cord-296585-yfh5d4io	550	18	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	550	19	disease	disease	NN
cord-296585-yfh5d4io	550	20	Granulocyte	Granulocyte	NNP
cord-296585-yfh5d4io	550	21	activation	activation	NN
cord-296585-yfh5d4io	550	22	markers	marker	NNS
cord-296585-yfh5d4io	550	23	in	in	IN
cord-296585-yfh5d4io	550	24	induced	induce	VBN
cord-296585-yfh5d4io	550	25	sputum	sputum	NN
cord-296585-yfh5d4io	550	26	:	:	:
cord-296585-yfh5d4io	551	1	comparison	comparison	NN
cord-296585-yfh5d4io	551	2	between	between	IN
cord-296585-yfh5d4io	551	3	chronic	chronic	JJ
cord-296585-yfh5d4io	551	4	obstructive	obstructive	JJ
cord-296585-yfh5d4io	551	5	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	551	6	disease	disease	NN
cord-296585-yfh5d4io	551	7	,	,	,
cord-296585-yfh5d4io	551	8	asthma	asthma	NN
cord-296585-yfh5d4io	551	9	,	,	,
cord-296585-yfh5d4io	551	10	and	and	CC
cord-296585-yfh5d4io	551	11	normal	normal	JJ
cord-296585-yfh5d4io	551	12	subjects	subject	NNS
cord-296585-yfh5d4io	552	1	Airway	airway	JJ
cord-296585-yfh5d4io	552	2	mucus	mucus	NN
cord-296585-yfh5d4io	552	3	function	function	NN
cord-296585-yfh5d4io	552	4	and	and	CC
cord-296585-yfh5d4io	553	1	dysfunction	dysfunction	NN
cord-296585-yfh5d4io	553	2	Molecular	Molecular	NNP
cord-296585-yfh5d4io	553	3	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	553	4	regulating	regulate	VBG
cord-296585-yfh5d4io	553	5	NLRP3	NLRP3	NNP
cord-296585-yfh5d4io	553	6	inflammasome	inflammasome	NNP
cord-296585-yfh5d4io	553	7	activation	activation	NN
cord-296585-yfh5d4io	553	8	Role	role	NN
cord-296585-yfh5d4io	553	9	of	of	IN
cord-296585-yfh5d4io	553	10	the	the	DT
cord-296585-yfh5d4io	553	11	inflammasome	inflammasome	NN
cord-296585-yfh5d4io	553	12	in	in	IN
cord-296585-yfh5d4io	553	13	chronic	chronic	JJ
cord-296585-yfh5d4io	553	14	obstructive	obstructive	JJ
cord-296585-yfh5d4io	553	15	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	553	16	disease	disease	NN
cord-296585-yfh5d4io	553	17	(	(	-LRB-
cord-296585-yfh5d4io	553	18	COPD	COPD	NNP
cord-296585-yfh5d4io	553	19	)	)	-RRB-
cord-296585-yfh5d4io	554	1	NLRP3	NLRP3	NNP
cord-296585-yfh5d4io	555	1	inflammasome	inflammasome	NNP
cord-296585-yfh5d4io	555	2	involves	involve	VBZ
cord-296585-yfh5d4io	555	3	in	in	IN
cord-296585-yfh5d4io	555	4	the	the	DT
cord-296585-yfh5d4io	555	5	acute	acute	JJ
cord-296585-yfh5d4io	555	6	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	555	7	of	of	IN
cord-296585-yfh5d4io	555	8	patients	patient	NNS
cord-296585-yfh5d4io	555	9	with	with	IN
cord-296585-yfh5d4io	555	10	chronic	chronic	JJ
cord-296585-yfh5d4io	555	11	obstructive	obstructive	JJ
cord-296585-yfh5d4io	555	12	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	555	13	disease	disease	NN
cord-296585-yfh5d4io	555	14	Inflammatory	Inflammatory	NNP
cord-296585-yfh5d4io	555	15	mediators	mediator	NNS
cord-296585-yfh5d4io	555	16	ATP	ATP	NNP
cord-296585-yfh5d4io	555	17	and	and	CC
cord-296585-yfh5d4io	555	18	S100A12	S100A12	NNS
cord-296585-yfh5d4io	555	19	activate	activate	VBP
cord-296585-yfh5d4io	555	20	the	the	DT
cord-296585-yfh5d4io	555	21	NLRP3	NLRP3	NNP
cord-296585-yfh5d4io	555	22	inflammasome	inflammasome	NNP
cord-296585-yfh5d4io	555	23	to	to	TO
cord-296585-yfh5d4io	555	24	induce	induce	VB
cord-296585-yfh5d4io	555	25	MUC5AC	MUC5AC	NNP
cord-296585-yfh5d4io	555	26	production	production	NN
cord-296585-yfh5d4io	555	27	in	in	IN
cord-296585-yfh5d4io	555	28	airway	airway	NN
cord-296585-yfh5d4io	555	29	epithelial	epithelial	JJ
cord-296585-yfh5d4io	555	30	cells	cell	NNS
cord-296585-yfh5d4io	556	1	The	the	DT
cord-296585-yfh5d4io	556	2	activation	activation	NN
cord-296585-yfh5d4io	556	3	of	of	IN
cord-296585-yfh5d4io	556	4	NLRP3-inflammsome	nlrp3-inflammsome	DT
cord-296585-yfh5d4io	556	5	by	by	IN
cord-296585-yfh5d4io	556	6	stimulation	stimulation	NN
cord-296585-yfh5d4io	556	7	of	of	IN
cord-296585-yfh5d4io	556	8	diesel	diesel	NN
cord-296585-yfh5d4io	556	9	exhaust	exhaust	NN
cord-296585-yfh5d4io	556	10	particles	particle	NNS
cord-296585-yfh5d4io	556	11	in	in	IN
cord-296585-yfh5d4io	556	12	lung	lung	NN
cord-296585-yfh5d4io	556	13	tissues	tissue	NNS
cord-296585-yfh5d4io	556	14	from	from	IN
cord-296585-yfh5d4io	556	15	emphysema	emphysema	NN
cord-296585-yfh5d4io	556	16	model	model	NN
cord-296585-yfh5d4io	556	17	and	and	CC
cord-296585-yfh5d4io	556	18	RAW	raw	JJ
cord-296585-yfh5d4io	556	19	264.7	264.7	CD
cord-296585-yfh5d4io	556	20	cell	cell	NN
cord-296585-yfh5d4io	556	21	line	line	NN
cord-296585-yfh5d4io	556	22	Accumulation	accumulation	NN
cord-296585-yfh5d4io	556	23	of	of	IN
cord-296585-yfh5d4io	556	24	dendritic	dendritic	JJ
cord-296585-yfh5d4io	556	25	cells	cell	NNS
cord-296585-yfh5d4io	556	26	and	and	CC
cord-296585-yfh5d4io	556	27	increased	increase	VBD
cord-296585-yfh5d4io	556	28	CCL20	ccl20	NN
cord-296585-yfh5d4io	556	29	levels	level	NNS
cord-296585-yfh5d4io	556	30	in	in	IN
cord-296585-yfh5d4io	556	31	the	the	DT
cord-296585-yfh5d4io	556	32	airways	airway	NNS
cord-296585-yfh5d4io	556	33	of	of	IN
cord-296585-yfh5d4io	556	34	patients	patient	NNS
cord-296585-yfh5d4io	556	35	with	with	IN
cord-296585-yfh5d4io	556	36	chronic	chronic	JJ
cord-296585-yfh5d4io	556	37	obstructive	obstructive	JJ
cord-296585-yfh5d4io	556	38	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	556	39	disease	disease	NN
cord-296585-yfh5d4io	556	40	Cigarette	Cigarette	NNP
cord-296585-yfh5d4io	556	41	smoke	smoke	NN
cord-296585-yfh5d4io	556	42	-	-	HYPH
cord-296585-yfh5d4io	556	43	induced	induce	VBN
cord-296585-yfh5d4io	556	44	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	556	45	emphysema	emphysema	NN
cord-296585-yfh5d4io	556	46	in	in	IN
cord-296585-yfh5d4io	556	47	scid	scid	NN
cord-296585-yfh5d4io	556	48	-	-	HYPH
cord-296585-yfh5d4io	556	49	mice	mouse	NNS
cord-296585-yfh5d4io	556	50	.	.	.
cord-296585-yfh5d4io	557	1	Is	be	VBZ
cord-296585-yfh5d4io	557	2	the	the	DT
cord-296585-yfh5d4io	557	3	acquired	acquire	VBN
cord-296585-yfh5d4io	557	4	immune	immune	JJ
cord-296585-yfh5d4io	557	5	system	system	NN
cord-296585-yfh5d4io	557	6	required	require	VBN
cord-296585-yfh5d4io	557	7	?	?	.
cord-296585-yfh5d4io	558	1	Dendritic	dendritic	JJ
cord-296585-yfh5d4io	558	2	cells	cell	NNS
cord-296585-yfh5d4io	558	3	in	in	IN
cord-296585-yfh5d4io	558	4	human	human	JJ
cord-296585-yfh5d4io	558	5	lung	lung	NN
cord-296585-yfh5d4io	558	6	disease	disease	NN
cord-296585-yfh5d4io	558	7	:	:	:
cord-296585-yfh5d4io	558	8	recent	recent	JJ
cord-296585-yfh5d4io	558	9	advances	advance	NNS
cord-296585-yfh5d4io	559	1	Increased	increase	VBN
cord-296585-yfh5d4io	559	2	expression	expression	NN
cord-296585-yfh5d4io	559	3	of	of	IN
cord-296585-yfh5d4io	559	4	the	the	DT
cord-296585-yfh5d4io	559	5	chemokine	chemokine	NN
cord-296585-yfh5d4io	559	6	receptor	receptor	NN
cord-296585-yfh5d4io	559	7	CXCR3	cxcr3	NN
cord-296585-yfh5d4io	559	8	and	and	CC
cord-296585-yfh5d4io	559	9	its	-PRON-	PRP$
cord-296585-yfh5d4io	559	10	ligand	ligand	NN
cord-296585-yfh5d4io	559	11	CXCL10	CXCL10	NNP
cord-296585-yfh5d4io	559	12	in	in	IN
cord-296585-yfh5d4io	559	13	peripheral	peripheral	JJ
cord-296585-yfh5d4io	559	14	airways	airway	NNS
cord-296585-yfh5d4io	559	15	of	of	IN
cord-296585-yfh5d4io	559	16	smokers	smoker	NNS
cord-296585-yfh5d4io	559	17	with	with	IN
cord-296585-yfh5d4io	559	18	chronic	chronic	JJ
cord-296585-yfh5d4io	559	19	obstructive	obstructive	JJ
cord-296585-yfh5d4io	559	20	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	559	21	disease	disease	NN
cord-296585-yfh5d4io	559	22	CXCR3	CXCR3	NNP
cord-296585-yfh5d4io	559	23	and	and	CC
cord-296585-yfh5d4io	559	24	CCR5	CCR5	NNP
cord-296585-yfh5d4io	559	25	chemokines	chemokine	NNS
cord-296585-yfh5d4io	559	26	in	in	IN
cord-296585-yfh5d4io	559	27	induced	induce	VBN
cord-296585-yfh5d4io	559	28	sputum	sputum	NN
cord-296585-yfh5d4io	559	29	from	from	IN
cord-296585-yfh5d4io	559	30	patients	patient	NNS
cord-296585-yfh5d4io	559	31	with	with	IN
cord-296585-yfh5d4io	559	32	COPD	COPD	NNP
cord-296585-yfh5d4io	559	33	Lymphocyte	Lymphocyte	NNP
cord-296585-yfh5d4io	559	34	population	population	NN
cord-296585-yfh5d4io	559	35	and	and	CC
cord-296585-yfh5d4io	559	36	apoptosis	apoptosis	NN
cord-296585-yfh5d4io	559	37	in	in	IN
cord-296585-yfh5d4io	559	38	the	the	DT
cord-296585-yfh5d4io	559	39	lungs	lung	NNS
cord-296585-yfh5d4io	559	40	of	of	IN
cord-296585-yfh5d4io	559	41	smokers	smoker	NNS
cord-296585-yfh5d4io	559	42	and	and	CC
cord-296585-yfh5d4io	559	43	their	-PRON-	PRP$
cord-296585-yfh5d4io	559	44	relation	relation	NN
cord-296585-yfh5d4io	559	45	to	to	IN
cord-296585-yfh5d4io	559	46	emphysema	emphysema	NN
cord-296585-yfh5d4io	559	47	T	T	NNP
cord-296585-yfh5d4io	559	48	helper	helper	NN
cord-296585-yfh5d4io	559	49	type	type	NN
cord-296585-yfh5d4io	559	50	17-related	17-related	CD
cord-296585-yfh5d4io	559	51	cytokine	cytokine	JJ
cord-296585-yfh5d4io	559	52	expression	expression	NN
cord-296585-yfh5d4io	559	53	is	be	VBZ
cord-296585-yfh5d4io	559	54	increased	increase	VBN
cord-296585-yfh5d4io	559	55	in	in	IN
cord-296585-yfh5d4io	559	56	the	the	DT
cord-296585-yfh5d4io	559	57	bronchial	bronchial	JJ
cord-296585-yfh5d4io	559	58	mucosa	mucosa	NN
cord-296585-yfh5d4io	559	59	of	of	IN
cord-296585-yfh5d4io	559	60	stable	stable	JJ
cord-296585-yfh5d4io	559	61	chronic	chronic	JJ
cord-296585-yfh5d4io	559	62	obstructive	obstructive	JJ
cord-296585-yfh5d4io	559	63	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	559	64	disease	disease	NN
cord-296585-yfh5d4io	559	65	patients	patient	NNS
cord-296585-yfh5d4io	559	66	Regulation	Regulation	NNP
cord-296585-yfh5d4io	559	67	of	of	IN
cord-296585-yfh5d4io	559	68	IL-17	IL-17	NNP
cord-296585-yfh5d4io	559	69	in	in	IN
cord-296585-yfh5d4io	559	70	chronic	chronic	JJ
cord-296585-yfh5d4io	559	71	inflammation	inflammation	NN
cord-296585-yfh5d4io	559	72	in	in	IN
cord-296585-yfh5d4io	559	73	the	the	DT
cord-296585-yfh5d4io	559	74	human	human	JJ
cord-296585-yfh5d4io	559	75	lung	lung	NN
cord-296585-yfh5d4io	559	76	Characterization	characterization	NN
cord-296585-yfh5d4io	559	77	and	and	CC
cord-296585-yfh5d4io	559	78	quantification	quantification	NN
cord-296585-yfh5d4io	559	79	of	of	IN
cord-296585-yfh5d4io	559	80	innate	innate	JJ
cord-296585-yfh5d4io	559	81	lymphoid	lymphoid	JJ
cord-296585-yfh5d4io	559	82	cell	cell	NN
cord-296585-yfh5d4io	559	83	subsets	subset	NNS
cord-296585-yfh5d4io	559	84	in	in	IN
cord-296585-yfh5d4io	559	85	human	human	JJ
cord-296585-yfh5d4io	559	86	lung	lung	NN
cord-296585-yfh5d4io	560	1	Increased	increase	VBN
cord-296585-yfh5d4io	561	1	IL-33	IL-33	NNP
cord-296585-yfh5d4io	561	2	expression	expression	NN
cord-296585-yfh5d4io	561	3	in	in	IN
cord-296585-yfh5d4io	561	4	chronic	chronic	JJ
cord-296585-yfh5d4io	561	5	obstructive	obstructive	JJ
cord-296585-yfh5d4io	561	6	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	561	7	disease	disease	NN
cord-296585-yfh5d4io	561	8	Expression	expression	NN
cord-296585-yfh5d4io	561	9	and	and	CC
cord-296585-yfh5d4io	561	10	cellular	cellular	JJ
cord-296585-yfh5d4io	561	11	provenance	provenance	NN
cord-296585-yfh5d4io	561	12	of	of	IN
cord-296585-yfh5d4io	561	13	thymic	thymic	JJ
cord-296585-yfh5d4io	561	14	stromal	stromal	JJ
cord-296585-yfh5d4io	561	15	lymphopoietin	lymphopoietin	NNS
cord-296585-yfh5d4io	561	16	and	and	CC
cord-296585-yfh5d4io	561	17	chemokines	chemokine	NNS
cord-296585-yfh5d4io	561	18	in	in	IN
cord-296585-yfh5d4io	561	19	patients	patient	NNS
cord-296585-yfh5d4io	561	20	with	with	IN
cord-296585-yfh5d4io	561	21	severe	severe	JJ
cord-296585-yfh5d4io	561	22	asthma	asthma	NN
cord-296585-yfh5d4io	561	23	and	and	CC
cord-296585-yfh5d4io	561	24	chronic	chronic	JJ
cord-296585-yfh5d4io	561	25	obstructive	obstructive	JJ
cord-296585-yfh5d4io	561	26	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	561	27	disease	disease	NN
cord-296585-yfh5d4io	561	28	Antielastin	Antielastin	VBZ
cord-296585-yfh5d4io	561	29	autoimmunity	autoimmunity	NN
cord-296585-yfh5d4io	561	30	in	in	IN
cord-296585-yfh5d4io	561	31	tobacco	tobacco	NN
cord-296585-yfh5d4io	561	32	smoking	smoking	NN
cord-296585-yfh5d4io	561	33	-	-	HYPH
cord-296585-yfh5d4io	561	34	induced	induce	VBN
cord-296585-yfh5d4io	561	35	emphysema	emphysema	NN
cord-296585-yfh5d4io	561	36	Antiendothelial	Antiendothelial	NNP
cord-296585-yfh5d4io	561	37	cell	cell	NN
cord-296585-yfh5d4io	561	38	antibodies	antibody	NNS
cord-296585-yfh5d4io	561	39	in	in	IN
cord-296585-yfh5d4io	561	40	patients	patient	NNS
cord-296585-yfh5d4io	561	41	with	with	IN
cord-296585-yfh5d4io	561	42	COPD	COPD	NNP
cord-296585-yfh5d4io	561	43	Autoantibodies	Autoantibodies	NNP
cord-296585-yfh5d4io	561	44	in	in	IN
cord-296585-yfh5d4io	561	45	patients	patient	NNS
cord-296585-yfh5d4io	561	46	with	with	IN
cord-296585-yfh5d4io	561	47	chronic	chronic	JJ
cord-296585-yfh5d4io	561	48	obstructive	obstructive	JJ
cord-296585-yfh5d4io	561	49	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	561	50	disease	disease	NN
cord-296585-yfh5d4io	561	51	Neutrophil	Neutrophil	NNP
cord-296585-yfh5d4io	561	52	priming	prime	VBG
cord-296585-yfh5d4io	561	53	by	by	IN
cord-296585-yfh5d4io	561	54	cigarette	cigarette	NN
cord-296585-yfh5d4io	561	55	smoke	smoke	NN
cord-296585-yfh5d4io	561	56	condensate	condensate	NN
cord-296585-yfh5d4io	561	57	and	and	CC
cord-296585-yfh5d4io	561	58	a	a	DT
cord-296585-yfh5d4io	561	59	tobacco	tobacco	NN
cord-296585-yfh5d4io	561	60	anti	anti	JJ
cord-296585-yfh5d4io	561	61	-	-	JJ
cord-296585-yfh5d4io	561	62	idiotypic	idiotypic	JJ
cord-296585-yfh5d4io	561	63	antibody	antibody	NN
cord-296585-yfh5d4io	561	64	Identification	Identification	NNP
cord-296585-yfh5d4io	561	65	of	of	IN
cord-296585-yfh5d4io	561	66	cytokeratin	cytokeratin	NNP
cord-296585-yfh5d4io	561	67	18	18	CD
cord-296585-yfh5d4io	561	68	as	as	IN
cord-296585-yfh5d4io	561	69	a	a	DT
cord-296585-yfh5d4io	561	70	bronchial	bronchial	JJ
cord-296585-yfh5d4io	561	71	epithelial	epithelial	JJ
cord-296585-yfh5d4io	561	72	autoantigen	autoantigen	NN
cord-296585-yfh5d4io	561	73	associated	associate	VBN
cord-296585-yfh5d4io	561	74	with	with	IN
cord-296585-yfh5d4io	561	75	nonallergic	nonallergic	JJ
cord-296585-yfh5d4io	561	76	asthma	asthma	NN
cord-296585-yfh5d4io	561	77	Autoimmunity	Autoimmunity	NNP
cord-296585-yfh5d4io	561	78	,	,	,
cord-296585-yfh5d4io	561	79	T	T	NNP
cord-296585-yfh5d4io	561	80	-	-	HYPH
cord-296585-yfh5d4io	561	81	cells	cell	NNS
cord-296585-yfh5d4io	561	82	and	and	CC
cord-296585-yfh5d4io	561	83	STAT-4	stat-4	NN
cord-296585-yfh5d4io	561	84	in	in	IN
cord-296585-yfh5d4io	561	85	the	the	DT
cord-296585-yfh5d4io	561	86	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	561	87	of	of	IN
cord-296585-yfh5d4io	561	88	chronic	chronic	JJ
cord-296585-yfh5d4io	561	89	obstructive	obstructive	JJ
cord-296585-yfh5d4io	561	90	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	561	91	disease	disease	NN
cord-296585-yfh5d4io	561	92	Hypothesis	Hypothesis	NNP
cord-296585-yfh5d4io	561	93	:	:	:
cord-296585-yfh5d4io	561	94	does	do	VBZ
cord-296585-yfh5d4io	561	95	COPD	COPD	NNP
cord-296585-yfh5d4io	561	96	have	have	VB
cord-296585-yfh5d4io	561	97	an	an	DT
cord-296585-yfh5d4io	561	98	autoimmune	autoimmune	JJ
cord-296585-yfh5d4io	561	99	component	component	NN
cord-296585-yfh5d4io	561	100	?	?	.
cord-296585-yfh5d4io	562	1	Oxidative	oxidative	JJ
cord-296585-yfh5d4io	562	2	stress	stress	NN
cord-296585-yfh5d4io	562	3	-	-	HYPH
cord-296585-yfh5d4io	562	4	induced	induce	VBN
cord-296585-yfh5d4io	562	5	antibodies	antibody	NNS
cord-296585-yfh5d4io	562	6	to	to	IN
cord-296585-yfh5d4io	562	7	carbonyl	carbonyl	NN
cord-296585-yfh5d4io	562	8	-	-	HYPH
cord-296585-yfh5d4io	562	9	modified	modify	VBN
cord-296585-yfh5d4io	562	10	protein	protein	NN
cord-296585-yfh5d4io	562	11	correlate	correlate	VBP
cord-296585-yfh5d4io	562	12	with	with	IN
cord-296585-yfh5d4io	562	13	severity	severity	NN
cord-296585-yfh5d4io	562	14	of	of	IN
cord-296585-yfh5d4io	562	15	chronic	chronic	JJ
cord-296585-yfh5d4io	562	16	obstructive	obstructive	JJ
cord-296585-yfh5d4io	562	17	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	562	18	disease	disease	NN
cord-296585-yfh5d4io	563	1	What	what	WP
cord-296585-yfh5d4io	563	2	is	be	VBZ
cord-296585-yfh5d4io	563	3	(	(	-LRB-
cord-296585-yfh5d4io	563	4	and	and	CC
cord-296585-yfh5d4io	563	5	what	what	WP
cord-296585-yfh5d4io	563	6	is	be	VBZ
cord-296585-yfh5d4io	563	7	not	not	RB
cord-296585-yfh5d4io	563	8	)	)	-RRB-
cord-296585-yfh5d4io	564	1	a	a	DT
cord-296585-yfh5d4io	564	2	COPD	COPD	NNP
cord-296585-yfh5d4io	564	3	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	564	4	:	:	:
cord-296585-yfh5d4io	564	5	thoughts	thought	NNS
cord-296585-yfh5d4io	564	6	from	from	IN
cord-296585-yfh5d4io	564	7	the	the	DT
cord-296585-yfh5d4io	564	8	new	new	JJ
cord-296585-yfh5d4io	564	9	GOLD	GOLD	NNP
cord-296585-yfh5d4io	564	10	guidelines	guideline	NNS
cord-296585-yfh5d4io	564	11	COPD	COPD	NNP
cord-296585-yfh5d4io	564	12	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	564	13	:	:	:
cord-296585-yfh5d4io	564	14	defining	define	VBG
cord-296585-yfh5d4io	564	15	their	-PRON-	PRP$
cord-296585-yfh5d4io	564	16	cause	cause	NN
cord-296585-yfh5d4io	564	17	and	and	CC
cord-296585-yfh5d4io	564	18	prevention	prevention	NN
cord-296585-yfh5d4io	564	19	Exacerbations	Exacerbations	NNPS
cord-296585-yfh5d4io	564	20	of	of	IN
cord-296585-yfh5d4io	564	21	COPD	COPD	NNP
cord-296585-yfh5d4io	564	22	Time	Time	NNP
cord-296585-yfh5d4io	564	23	course	course	NN
cord-296585-yfh5d4io	564	24	and	and	CC
cord-296585-yfh5d4io	564	25	recovery	recovery	NN
cord-296585-yfh5d4io	564	26	of	of	IN
cord-296585-yfh5d4io	564	27	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	564	28	in	in	IN
cord-296585-yfh5d4io	564	29	patients	patient	NNS
cord-296585-yfh5d4io	564	30	with	with	IN
cord-296585-yfh5d4io	564	31	chronic	chronic	JJ
cord-296585-yfh5d4io	564	32	obstructive	obstructive	JJ
cord-296585-yfh5d4io	564	33	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	564	34	disease	disease	NN
cord-296585-yfh5d4io	564	35	Acute	acute	JJ
cord-296585-yfh5d4io	564	36	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	564	37	of	of	IN
cord-296585-yfh5d4io	564	38	COPD	COPD	NNP
cord-296585-yfh5d4io	564	39	Role	role	NN
cord-296585-yfh5d4io	564	40	of	of	IN
cord-296585-yfh5d4io	564	41	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	564	42	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	564	43	influenzae	influenzae	NN
cord-296585-yfh5d4io	564	44	in	in	IN
cord-296585-yfh5d4io	564	45	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	564	46	and	and	CC
cord-296585-yfh5d4io	564	47	progression	progression	NN
cord-296585-yfh5d4io	564	48	of	of	IN
cord-296585-yfh5d4io	564	49	chronic	chronic	JJ
cord-296585-yfh5d4io	564	50	obstructive	obstructive	JJ
cord-296585-yfh5d4io	564	51	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	564	52	disease	disease	NN
cord-296585-yfh5d4io	564	53	Exacerbations	Exacerbations	NNPS
cord-296585-yfh5d4io	564	54	of	of	IN
cord-296585-yfh5d4io	564	55	chronic	chronic	JJ
cord-296585-yfh5d4io	564	56	obstructive	obstructive	JJ
cord-296585-yfh5d4io	564	57	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	564	58	disease	disease	NN
cord-296585-yfh5d4io	565	1	A	a	DT
cord-296585-yfh5d4io	565	2	prospective	prospective	JJ
cord-296585-yfh5d4io	565	3	,	,	,
cord-296585-yfh5d4io	565	4	observational	observational	JJ
cord-296585-yfh5d4io	565	5	cohort	cohort	NN
cord-296585-yfh5d4io	565	6	study	study	NN
cord-296585-yfh5d4io	565	7	of	of	IN
cord-296585-yfh5d4io	565	8	the	the	DT
cord-296585-yfh5d4io	565	9	seasonal	seasonal	JJ
cord-296585-yfh5d4io	565	10	dynamics	dynamic	NNS
cord-296585-yfh5d4io	565	11	of	of	IN
cord-296585-yfh5d4io	565	12	airway	airway	NN
cord-296585-yfh5d4io	565	13	pathogens	pathogen	NNS
cord-296585-yfh5d4io	565	14	in	in	IN
cord-296585-yfh5d4io	565	15	the	the	DT
cord-296585-yfh5d4io	565	16	aetiology	aetiology	NN
cord-296585-yfh5d4io	565	17	of	of	IN
cord-296585-yfh5d4io	565	18	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	565	19	in	in	IN
cord-296585-yfh5d4io	565	20	COPD	COPD	NNP
cord-296585-yfh5d4io	565	21	Respiratory	respiratory	JJ
cord-296585-yfh5d4io	565	22	viruses	virus	NNS
cord-296585-yfh5d4io	565	23	,	,	,
cord-296585-yfh5d4io	565	24	symptoms	symptom	NNS
cord-296585-yfh5d4io	565	25	,	,	,
cord-296585-yfh5d4io	565	26	and	and	CC
cord-296585-yfh5d4io	565	27	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	565	28	markers	marker	NNS
cord-296585-yfh5d4io	565	29	in	in	IN
cord-296585-yfh5d4io	565	30	acute	acute	JJ
cord-296585-yfh5d4io	565	31	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	565	32	and	and	CC
cord-296585-yfh5d4io	565	33	stable	stable	JJ
cord-296585-yfh5d4io	565	34	chronic	chronic	JJ
cord-296585-yfh5d4io	565	35	obstructive	obstructive	JJ
cord-296585-yfh5d4io	565	36	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	565	37	disease	disease	NN
cord-296585-yfh5d4io	565	38	Virus	virus	NN
cord-296585-yfh5d4io	565	39	-	-	HYPH
cord-296585-yfh5d4io	565	40	induced	induce	VBN
cord-296585-yfh5d4io	565	41	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	565	42	in	in	IN
cord-296585-yfh5d4io	565	43	asthma	asthma	NN
cord-296585-yfh5d4io	565	44	and	and	CC
cord-296585-yfh5d4io	565	45	COPD	COPD	NNP
cord-296585-yfh5d4io	565	46	Prevalence	prevalence	NN
cord-296585-yfh5d4io	565	47	of	of	IN
cord-296585-yfh5d4io	565	48	viral	viral	JJ
cord-296585-yfh5d4io	565	49	infection	infection	NN
cord-296585-yfh5d4io	565	50	detected	detect	VBN
cord-296585-yfh5d4io	565	51	by	by	IN
cord-296585-yfh5d4io	565	52	PCR	PCR	NNP
cord-296585-yfh5d4io	565	53	and	and	CC
cord-296585-yfh5d4io	565	54	RT	RT	NNP
cord-296585-yfh5d4io	565	55	-	-	HYPH
cord-296585-yfh5d4io	565	56	PCR	PCR	NNP
cord-296585-yfh5d4io	565	57	in	in	IN
cord-296585-yfh5d4io	565	58	patients	patient	NNS
cord-296585-yfh5d4io	565	59	with	with	IN
cord-296585-yfh5d4io	565	60	acute	acute	JJ
cord-296585-yfh5d4io	565	61	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	565	62	of	of	IN
cord-296585-yfh5d4io	565	63	COPD	COPD	NNP
cord-296585-yfh5d4io	565	64	:	:	:
cord-296585-yfh5d4io	565	65	a	a	DT
cord-296585-yfh5d4io	565	66	systematic	systematic	JJ
cord-296585-yfh5d4io	565	67	review	review	NN
cord-296585-yfh5d4io	566	1	Viruses	virus	NNS
cord-296585-yfh5d4io	566	2	are	be	VBP
cord-296585-yfh5d4io	566	3	frequently	frequently	RB
cord-296585-yfh5d4io	566	4	present	present	JJ
cord-296585-yfh5d4io	566	5	as	as	IN
cord-296585-yfh5d4io	566	6	the	the	DT
cord-296585-yfh5d4io	566	7	infecting	infect	VBG
cord-296585-yfh5d4io	566	8	agent	agent	NN
cord-296585-yfh5d4io	566	9	in	in	IN
cord-296585-yfh5d4io	566	10	acute	acute	JJ
cord-296585-yfh5d4io	566	11	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	566	12	of	of	IN
cord-296585-yfh5d4io	566	13	chronic	chronic	JJ
cord-296585-yfh5d4io	566	14	obstructive	obstructive	JJ
cord-296585-yfh5d4io	566	15	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	566	16	disease	disease	NN
cord-296585-yfh5d4io	566	17	in	in	IN
cord-296585-yfh5d4io	566	18	patients	patient	NNS
cord-296585-yfh5d4io	566	19	presenting	present	VBG
cord-296585-yfh5d4io	566	20	to	to	IN
cord-296585-yfh5d4io	566	21	hospital	hospital	NN
cord-296585-yfh5d4io	567	1	The	the	DT
cord-296585-yfh5d4io	567	2	role	role	NN
cord-296585-yfh5d4io	567	3	of	of	IN
cord-296585-yfh5d4io	567	4	viral	viral	JJ
cord-296585-yfh5d4io	567	5	infections	infection	NNS
cord-296585-yfh5d4io	567	6	in	in	IN
cord-296585-yfh5d4io	567	7	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	567	8	of	of	IN
cord-296585-yfh5d4io	567	9	chronic	chronic	JJ
cord-296585-yfh5d4io	567	10	obstructive	obstructive	JJ
cord-296585-yfh5d4io	567	11	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	567	12	disease	disease	NN
cord-296585-yfh5d4io	567	13	and	and	CC
cord-296585-yfh5d4io	567	14	asthma	asthma	NN
cord-296585-yfh5d4io	567	15	Respiratory	respiratory	JJ
cord-296585-yfh5d4io	567	16	viruses	virus	NNS
cord-296585-yfh5d4io	567	17	in	in	IN
cord-296585-yfh5d4io	567	18	acute	acute	JJ
cord-296585-yfh5d4io	567	19	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	567	20	of	of	IN
cord-296585-yfh5d4io	567	21	chronic	chronic	JJ
cord-296585-yfh5d4io	567	22	obstructive	obstructive	JJ
cord-296585-yfh5d4io	567	23	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	567	24	disease	disease	NN
cord-296585-yfh5d4io	567	25	Worldwide	worldwide	JJ
cord-296585-yfh5d4io	567	26	prevalence	prevalence	NN
cord-296585-yfh5d4io	567	27	of	of	IN
cord-296585-yfh5d4io	567	28	viral	viral	JJ
cord-296585-yfh5d4io	567	29	infection	infection	NN
cord-296585-yfh5d4io	567	30	in	in	IN
cord-296585-yfh5d4io	567	31	AECOPD	AECOPD	NNP
cord-296585-yfh5d4io	567	32	patients	patient	NNS
cord-296585-yfh5d4io	567	33	:	:	:
cord-296585-yfh5d4io	567	34	a	a	DT
cord-296585-yfh5d4io	567	35	meta	meta	NN
cord-296585-yfh5d4io	567	36	-	-	HYPH
cord-296585-yfh5d4io	567	37	analysis	analysis	NN
cord-296585-yfh5d4io	567	38	.	.	.
cord-296585-yfh5d4io	568	1	Microb	Microb	NNP
cord-296585-yfh5d4io	568	2	Pathog	Pathog	NNP
cord-296585-yfh5d4io	568	3	Respiratory	respiratory	JJ
cord-296585-yfh5d4io	568	4	viral	viral	JJ
cord-296585-yfh5d4io	568	5	infections	infection	NNS
cord-296585-yfh5d4io	568	6	in	in	IN
cord-296585-yfh5d4io	568	7	chronic	chronic	JJ
cord-296585-yfh5d4io	568	8	lung	lung	NN
cord-296585-yfh5d4io	568	9	diseases	disease	NNS
cord-296585-yfh5d4io	568	10	Analysis	Analysis	NNP
cord-296585-yfh5d4io	568	11	of	of	IN
cord-296585-yfh5d4io	568	12	viral	viral	JJ
cord-296585-yfh5d4io	568	13	infection	infection	NN
cord-296585-yfh5d4io	568	14	and	and	CC
cord-296585-yfh5d4io	568	15	biomarkers	biomarker	NNS
cord-296585-yfh5d4io	568	16	in	in	IN
cord-296585-yfh5d4io	568	17	patients	patient	NNS
cord-296585-yfh5d4io	568	18	with	with	IN
cord-296585-yfh5d4io	568	19	acute	acute	JJ
cord-296585-yfh5d4io	568	20	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	568	21	of	of	IN
cord-296585-yfh5d4io	568	22	chronic	chronic	JJ
cord-296585-yfh5d4io	568	23	obstructive	obstructive	JJ
cord-296585-yfh5d4io	568	24	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	568	25	disease	disease	NN
cord-296585-yfh5d4io	569	1	Predicting	predict	VBG
cord-296585-yfh5d4io	569	2	early	early	JJ
cord-296585-yfh5d4io	569	3	mortality	mortality	NN
cord-296585-yfh5d4io	569	4	in	in	IN
cord-296585-yfh5d4io	569	5	acute	acute	JJ
cord-296585-yfh5d4io	569	6	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	569	7	of	of	IN
cord-296585-yfh5d4io	569	8	chronic	chronic	JJ
cord-296585-yfh5d4io	569	9	obstructive	obstructive	JJ
cord-296585-yfh5d4io	569	10	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	569	11	disease	disease	NN
cord-296585-yfh5d4io	569	12	using	use	VBG
cord-296585-yfh5d4io	569	13	the	the	DT
cord-296585-yfh5d4io	569	14	CURB65	CURB65	NNP
cord-296585-yfh5d4io	569	15	score	score	NN
cord-296585-yfh5d4io	569	16	Vulnerability	vulnerability	NN
cord-296585-yfh5d4io	569	17	,	,	,
cord-296585-yfh5d4io	569	18	beliefs	belief	NNS
cord-296585-yfh5d4io	569	19	,	,	,
cord-296585-yfh5d4io	569	20	treatments	treatment	NNS
cord-296585-yfh5d4io	569	21	and	and	CC
cord-296585-yfh5d4io	569	22	economic	economic	JJ
cord-296585-yfh5d4io	569	23	burden	burden	NN
cord-296585-yfh5d4io	569	24	of	of	IN
cord-296585-yfh5d4io	569	25	chronic	chronic	JJ
cord-296585-yfh5d4io	569	26	obstructive	obstructive	JJ
cord-296585-yfh5d4io	569	27	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	569	28	disease	disease	NN
cord-296585-yfh5d4io	569	29	in	in	IN
cord-296585-yfh5d4io	569	30	rural	rural	JJ
cord-296585-yfh5d4io	569	31	areas	area	NNS
cord-296585-yfh5d4io	569	32	in	in	IN
cord-296585-yfh5d4io	569	33	China	China	NNP
cord-296585-yfh5d4io	569	34	:	:	:
cord-296585-yfh5d4io	569	35	a	a	DT
cord-296585-yfh5d4io	569	36	cross	cross	JJ
cord-296585-yfh5d4io	569	37	-	-	JJ
cord-296585-yfh5d4io	569	38	sectional	sectional	JJ
cord-296585-yfh5d4io	569	39	study	study	NN
cord-296585-yfh5d4io	569	40	Microbiologic	Microbiologic	NNP
cord-296585-yfh5d4io	569	41	determinants	determinant	NNS
cord-296585-yfh5d4io	569	42	of	of	IN
cord-296585-yfh5d4io	569	43	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	569	44	in	in	IN
cord-296585-yfh5d4io	569	45	chronic	chronic	JJ
cord-296585-yfh5d4io	569	46	obstructive	obstructive	JJ
cord-296585-yfh5d4io	569	47	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	569	48	disease	disease	NN
cord-296585-yfh5d4io	569	49	Lung	lung	NN
cord-296585-yfh5d4io	569	50	microbiome	microbiome	NN
cord-296585-yfh5d4io	569	51	dynamics	dynamic	NNS
cord-296585-yfh5d4io	569	52	in	in	IN
cord-296585-yfh5d4io	569	53	COPD	COPD	NNP
cord-296585-yfh5d4io	569	54	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	569	55	Pneumonic	pneumonic	JJ
cord-296585-yfh5d4io	569	56	and	and	CC
cord-296585-yfh5d4io	569	57	non	non	JJ
cord-296585-yfh5d4io	569	58	-	-	JJ
cord-296585-yfh5d4io	569	59	pneumonic	pneumonic	JJ
cord-296585-yfh5d4io	569	60	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	569	61	in	in	IN
cord-296585-yfh5d4io	569	62	bronchiectasis	bronchiectasis	NN
cord-296585-yfh5d4io	569	63	:	:	:
cord-296585-yfh5d4io	569	64	clinical	clinical	JJ
cord-296585-yfh5d4io	569	65	and	and	CC
cord-296585-yfh5d4io	569	66	microbiological	microbiological	JJ
cord-296585-yfh5d4io	569	67	differences	difference	NNS
cord-296585-yfh5d4io	569	68	Longitudinal	longitudinal	JJ
cord-296585-yfh5d4io	569	69	profiling	profiling	NN
cord-296585-yfh5d4io	569	70	of	of	IN
cord-296585-yfh5d4io	569	71	the	the	DT
cord-296585-yfh5d4io	569	72	lung	lung	NN
cord-296585-yfh5d4io	569	73	microbiome	microbiome	NN
cord-296585-yfh5d4io	569	74	in	in	IN
cord-296585-yfh5d4io	569	75	the	the	DT
cord-296585-yfh5d4io	569	76	AERIS	AERIS	NNP
cord-296585-yfh5d4io	569	77	study	study	NN
cord-296585-yfh5d4io	569	78	demonstrates	demonstrate	VBZ
cord-296585-yfh5d4io	569	79	repeatability	repeatability	NN
cord-296585-yfh5d4io	569	80	of	of	IN
cord-296585-yfh5d4io	569	81	bacterial	bacterial	JJ
cord-296585-yfh5d4io	569	82	and	and	CC
cord-296585-yfh5d4io	569	83	eosinophilic	eosinophilic	JJ
cord-296585-yfh5d4io	569	84	COPD	COPD	NNP
cord-296585-yfh5d4io	569	85	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	569	86	COPD	COPD	NNP
cord-296585-yfh5d4io	569	87	is	be	VBZ
cord-296585-yfh5d4io	569	88	characterized	characterize	VBN
cord-296585-yfh5d4io	569	89	by	by	IN
cord-296585-yfh5d4io	569	90	increased	increase	VBN
cord-296585-yfh5d4io	569	91	detection	detection	NN
cord-296585-yfh5d4io	569	92	of	of	IN
cord-296585-yfh5d4io	569	93	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	569	94	influenzae	influenzae	NN
cord-296585-yfh5d4io	569	95	,	,	,
cord-296585-yfh5d4io	569	96	Streptococcus	streptococcus	NN
cord-296585-yfh5d4io	569	97	pneumoniae	pneumoniae	NN
cord-296585-yfh5d4io	569	98	and	and	CC
cord-296585-yfh5d4io	569	99	a	a	DT
cord-296585-yfh5d4io	569	100	deficiency	deficiency	NN
cord-296585-yfh5d4io	569	101	of	of	IN
cord-296585-yfh5d4io	569	102	Bacillus	Bacillus	NNP
cord-296585-yfh5d4io	569	103	species	specie	VBZ
cord-296585-yfh5d4io	569	104	New	new	JJ
cord-296585-yfh5d4io	569	105	strains	strain	NNS
cord-296585-yfh5d4io	569	106	of	of	IN
cord-296585-yfh5d4io	569	107	bacteria	bacteria	NNS
cord-296585-yfh5d4io	569	108	and	and	CC
cord-296585-yfh5d4io	569	109	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	569	110	of	of	IN
cord-296585-yfh5d4io	569	111	chronic	chronic	JJ
cord-296585-yfh5d4io	569	112	obstructive	obstructive	JJ
cord-296585-yfh5d4io	569	113	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	569	114	disease	disease	NN
cord-296585-yfh5d4io	569	115	Role	role	NN
cord-296585-yfh5d4io	569	116	of	of	IN
cord-296585-yfh5d4io	569	117	infections	infection	NNS
cord-296585-yfh5d4io	569	118	Acute	acute	JJ
cord-296585-yfh5d4io	569	119	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	569	120	of	of	IN
cord-296585-yfh5d4io	569	121	chronic	chronic	JJ
cord-296585-yfh5d4io	569	122	obstructive	obstructive	JJ
cord-296585-yfh5d4io	569	123	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	569	124	disease	disease	NN
cord-296585-yfh5d4io	569	125	:	:	:
cord-296585-yfh5d4io	569	126	identification	identification	NN
cord-296585-yfh5d4io	569	127	of	of	IN
cord-296585-yfh5d4io	569	128	biologic	biologic	JJ
cord-296585-yfh5d4io	569	129	clusters	cluster	NNS
cord-296585-yfh5d4io	569	130	and	and	CC
cord-296585-yfh5d4io	569	131	their	-PRON-	PRP$
cord-296585-yfh5d4io	569	132	biomarkers	biomarker	NNS
cord-296585-yfh5d4io	569	133	Human	human	JJ
cord-296585-yfh5d4io	569	134	rhinovirus	rhinovirus	NN
cord-296585-yfh5d4io	569	135	infection	infection	NN
cord-296585-yfh5d4io	569	136	during	during	IN
cord-296585-yfh5d4io	569	137	naturally	naturally	RB
cord-296585-yfh5d4io	569	138	occurring	occur	VBG
cord-296585-yfh5d4io	569	139	COPD	COPD	NNP
cord-296585-yfh5d4io	569	140	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	569	141	Respiratory	respiratory	JJ
cord-296585-yfh5d4io	569	142	viral	viral	JJ
cord-296585-yfh5d4io	569	143	detection	detection	NN
cord-296585-yfh5d4io	569	144	and	and	CC
cord-296585-yfh5d4io	569	145	small	small	JJ
cord-296585-yfh5d4io	569	146	airway	airway	NN
cord-296585-yfh5d4io	569	147	inflammation	inflammation	NN
cord-296585-yfh5d4io	569	148	in	in	IN
cord-296585-yfh5d4io	569	149	lung	lung	NN
cord-296585-yfh5d4io	569	150	tissue	tissue	NN
cord-296585-yfh5d4io	569	151	of	of	IN
cord-296585-yfh5d4io	569	152	patients	patient	NNS
cord-296585-yfh5d4io	569	153	with	with	IN
cord-296585-yfh5d4io	569	154	stable	stable	JJ
cord-296585-yfh5d4io	569	155	,	,	,
cord-296585-yfh5d4io	569	156	mild	mild	JJ
cord-296585-yfh5d4io	569	157	COPD	COPD	NNP
cord-296585-yfh5d4io	569	158	Bacterial	bacterial	JJ
cord-296585-yfh5d4io	569	159	-	-	HYPH
cord-296585-yfh5d4io	569	160	viral	viral	JJ
cord-296585-yfh5d4io	569	161	load	load	NN
cord-296585-yfh5d4io	569	162	and	and	CC
cord-296585-yfh5d4io	569	163	the	the	DT
cord-296585-yfh5d4io	569	164	immune	immune	JJ
cord-296585-yfh5d4io	569	165	response	response	NN
cord-296585-yfh5d4io	569	166	in	in	IN
cord-296585-yfh5d4io	569	167	stable	stable	JJ
cord-296585-yfh5d4io	569	168	and	and	CC
cord-296585-yfh5d4io	569	169	exacerbated	exacerbated	JJ
cord-296585-yfh5d4io	569	170	COPD	COPD	NNP
cord-296585-yfh5d4io	569	171	:	:	:
cord-296585-yfh5d4io	569	172	significance	significance	NN
cord-296585-yfh5d4io	569	173	and	and	CC
cord-296585-yfh5d4io	569	174	therapeutic	therapeutic	JJ
cord-296585-yfh5d4io	569	175	prospects	prospect	NNS
cord-296585-yfh5d4io	570	1	Rhinovirus	rhinovirus	NN
cord-296585-yfh5d4io	570	2	attenuates	attenuate	VBZ
cord-296585-yfh5d4io	570	3	non	non	JJ
cord-296585-yfh5d4io	570	4	-	-	JJ
cord-296585-yfh5d4io	570	5	typeable	typeable	JJ
cord-296585-yfh5d4io	570	6	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	570	7	influenzae	influenzae	NN
cord-296585-yfh5d4io	570	8	-	-	HYPH
cord-296585-yfh5d4io	570	9	stimulated	stimulate	VBN
cord-296585-yfh5d4io	570	10	IL-8	il-8	NN
cord-296585-yfh5d4io	570	11	responses	response	NNS
cord-296585-yfh5d4io	570	12	via	via	IN
cord-296585-yfh5d4io	570	13	TLR2-dependent	TLR2-dependent	NNP
cord-296585-yfh5d4io	570	14	degradation	degradation	NN
cord-296585-yfh5d4io	570	15	of	of	IN
cord-296585-yfh5d4io	570	16	IRAK-1	irak-1	JJ
cord-296585-yfh5d4io	570	17	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	570	18	influenzae	influenzae	NN
cord-296585-yfh5d4io	570	19	increases	increase	VBZ
cord-296585-yfh5d4io	570	20	the	the	DT
cord-296585-yfh5d4io	570	21	susceptibility	susceptibility	NN
cord-296585-yfh5d4io	570	22	and	and	CC
cord-296585-yfh5d4io	570	23	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	570	24	response	response	NN
cord-296585-yfh5d4io	570	25	of	of	IN
cord-296585-yfh5d4io	570	26	airway	airway	NN
cord-296585-yfh5d4io	570	27	epithelial	epithelial	JJ
cord-296585-yfh5d4io	570	28	cells	cell	NNS
cord-296585-yfh5d4io	570	29	to	to	IN
cord-296585-yfh5d4io	570	30	viral	viral	JJ
cord-296585-yfh5d4io	570	31	infections	infection	NNS
cord-296585-yfh5d4io	570	32	Exposure	exposure	NN
cord-296585-yfh5d4io	570	33	to	to	IN
cord-296585-yfh5d4io	570	34	common	common	JJ
cord-296585-yfh5d4io	570	35	respiratory	respiratory	JJ
cord-296585-yfh5d4io	570	36	bacteria	bacteria	NNS
cord-296585-yfh5d4io	571	1	alters	alter	VBZ
cord-296585-yfh5d4io	571	2	the	the	DT
cord-296585-yfh5d4io	571	3	airway	airway	JJ
cord-296585-yfh5d4io	571	4	epithelial	epithelial	JJ
cord-296585-yfh5d4io	571	5	response	response	NN
cord-296585-yfh5d4io	571	6	to	to	IN
cord-296585-yfh5d4io	571	7	subsequent	subsequent	JJ
cord-296585-yfh5d4io	571	8	viral	viral	JJ
cord-296585-yfh5d4io	571	9	infection	infection	NN
cord-296585-yfh5d4io	571	10	Rhinovirus	Rhinovirus	NNP
cord-296585-yfh5d4io	571	11	disrupts	disrupt	VBZ
cord-296585-yfh5d4io	571	12	the	the	DT
cord-296585-yfh5d4io	571	13	barrier	barrier	NN
cord-296585-yfh5d4io	571	14	function	function	NN
cord-296585-yfh5d4io	571	15	of	of	IN
cord-296585-yfh5d4io	571	16	polarized	polarized	JJ
cord-296585-yfh5d4io	571	17	airway	airway	NN
cord-296585-yfh5d4io	571	18	epithelial	epithelial	JJ
cord-296585-yfh5d4io	571	19	cells	cell	NNS
cord-296585-yfh5d4io	572	1	Rhinovirus	rhinovirus	NN
cord-296585-yfh5d4io	572	2	enhances	enhance	VBZ
cord-296585-yfh5d4io	572	3	various	various	JJ
cord-296585-yfh5d4io	572	4	bacterial	bacterial	JJ
cord-296585-yfh5d4io	572	5	adhesions	adhesion	NNS
cord-296585-yfh5d4io	572	6	to	to	TO
cord-296585-yfh5d4io	572	7	nasal	nasal	VB
cord-296585-yfh5d4io	572	8	epithelial	epithelial	JJ
cord-296585-yfh5d4io	572	9	cells	cell	NNS
cord-296585-yfh5d4io	572	10	simultaneously	simultaneously	RB
cord-296585-yfh5d4io	572	11	Mechanisms	mechanism	NNS
cord-296585-yfh5d4io	572	12	of	of	IN
cord-296585-yfh5d4io	572	13	severe	severe	JJ
cord-296585-yfh5d4io	572	14	mortality	mortality	NN
cord-296585-yfh5d4io	572	15	-	-	HYPH
cord-296585-yfh5d4io	572	16	associated	associate	VBN
cord-296585-yfh5d4io	572	17	bacterial	bacterial	JJ
cord-296585-yfh5d4io	572	18	co	co	NNS
cord-296585-yfh5d4io	572	19	-	-	NNS
cord-296585-yfh5d4io	572	20	infections	infection	NNS
cord-296585-yfh5d4io	572	21	following	follow	VBG
cord-296585-yfh5d4io	572	22	influenza	influenza	NN
cord-296585-yfh5d4io	572	23	virus	virus	NN
cord-296585-yfh5d4io	572	24	infection	infection	NN
cord-296585-yfh5d4io	572	25	.	.	.
cord-296585-yfh5d4io	573	1	Front	front	JJ
cord-296585-yfh5d4io	573	2	Cell	cell	NN
cord-296585-yfh5d4io	573	3	Infect	infect	VBP
cord-296585-yfh5d4io	573	4	Microbiol	Microbiol	NNP
cord-296585-yfh5d4io	573	5	Rhinovirus	Rhinovirus	NNP
cord-296585-yfh5d4io	573	6	exposure	exposure	NN
cord-296585-yfh5d4io	573	7	impairs	impair	VBZ
cord-296585-yfh5d4io	573	8	immune	immune	JJ
cord-296585-yfh5d4io	573	9	responses	response	NNS
cord-296585-yfh5d4io	573	10	to	to	IN
cord-296585-yfh5d4io	573	11	bacterial	bacterial	JJ
cord-296585-yfh5d4io	573	12	products	product	NNS
cord-296585-yfh5d4io	573	13	in	in	IN
cord-296585-yfh5d4io	573	14	human	human	JJ
cord-296585-yfh5d4io	573	15	alveolar	alveolar	NN
cord-296585-yfh5d4io	573	16	macrophages	macrophage	NNS
cord-296585-yfh5d4io	573	17	Human	Human	NNP
cord-296585-yfh5d4io	573	18	β	β	NNP
cord-296585-yfh5d4io	573	19	-	-	HYPH
cord-296585-yfh5d4io	573	20	defensin-2	defensin-2	NN
cord-296585-yfh5d4io	573	21	production	production	NN
cord-296585-yfh5d4io	573	22	upon	upon	IN
cord-296585-yfh5d4io	573	23	viral	viral	JJ
cord-296585-yfh5d4io	573	24	and	and	CC
cord-296585-yfh5d4io	573	25	bacterial	bacterial	JJ
cord-296585-yfh5d4io	573	26	co	co	NN
cord-296585-yfh5d4io	573	27	-	-	NN
cord-296585-yfh5d4io	573	28	infection	infection	NN
cord-296585-yfh5d4io	573	29	is	be	VBZ
cord-296585-yfh5d4io	573	30	attenuated	attenuate	VBN
cord-296585-yfh5d4io	573	31	in	in	IN
cord-296585-yfh5d4io	573	32	COPD	COPD	NNP
cord-296585-yfh5d4io	574	1	The	the	DT
cord-296585-yfh5d4io	574	2	co	co	NN
cord-296585-yfh5d4io	574	3	-	-	NN
cord-296585-yfh5d4io	574	4	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	574	5	of	of	IN
cord-296585-yfh5d4io	574	6	influenza	influenza	NN
cord-296585-yfh5d4io	574	7	viruses	virus	NNS
cord-296585-yfh5d4io	574	8	with	with	IN
cord-296585-yfh5d4io	574	9	bacteria	bacteria	NNS
cord-296585-yfh5d4io	574	10	in	in	IN
cord-296585-yfh5d4io	574	11	the	the	DT
cord-296585-yfh5d4io	574	12	lung	lung	NN
cord-296585-yfh5d4io	574	13	Viral	viral	JJ
cord-296585-yfh5d4io	574	14	-	-	HYPH
cord-296585-yfh5d4io	574	15	bacterial	bacterial	JJ
cord-296585-yfh5d4io	574	16	interactions	interaction	NNS
cord-296585-yfh5d4io	574	17	in	in	IN
cord-296585-yfh5d4io	574	18	the	the	DT
cord-296585-yfh5d4io	574	19	respiratory	respiratory	JJ
cord-296585-yfh5d4io	574	20	tract	tract	NN
cord-296585-yfh5d4io	574	21	Viral	viral	JJ
cord-296585-yfh5d4io	574	22	,	,	,
cord-296585-yfh5d4io	574	23	bacterial	bacterial	JJ
cord-296585-yfh5d4io	574	24	or	or	CC
cord-296585-yfh5d4io	574	25	both	both	DT
cord-296585-yfh5d4io	574	26	?	?	.
cord-296585-yfh5d4io	575	1	Regardless	regardless	RB
cord-296585-yfh5d4io	575	2	,	,	,
cord-296585-yfh5d4io	575	3	we	-PRON-	PRP
cord-296585-yfh5d4io	575	4	need	need	VBP
cord-296585-yfh5d4io	575	5	to	to	TO
cord-296585-yfh5d4io	575	6	treat	treat	VB
cord-296585-yfh5d4io	575	7	infection	infection	NN
cord-296585-yfh5d4io	575	8	in	in	IN
cord-296585-yfh5d4io	575	9	COPD	COPD	NNP
cord-296585-yfh5d4io	575	10	Viral	viral	JJ
cord-296585-yfh5d4io	575	11	and	and	CC
cord-296585-yfh5d4io	575	12	bacterial	bacterial	JJ
cord-296585-yfh5d4io	575	13	infection	infection	NN
cord-296585-yfh5d4io	575	14	in	in	IN
cord-296585-yfh5d4io	575	15	acute	acute	JJ
cord-296585-yfh5d4io	575	16	asthma	asthma	NN
cord-296585-yfh5d4io	575	17	and	and	CC
cord-296585-yfh5d4io	575	18	chronic	chronic	JJ
cord-296585-yfh5d4io	575	19	obstructive	obstructive	JJ
cord-296585-yfh5d4io	575	20	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	575	21	disease	disease	NN
cord-296585-yfh5d4io	576	1	increases	increase	VBZ
cord-296585-yfh5d4io	576	2	the	the	DT
cord-296585-yfh5d4io	576	3	risk	risk	NN
cord-296585-yfh5d4io	576	4	of	of	IN
cord-296585-yfh5d4io	576	5	readmission	readmission	NN
cord-296585-yfh5d4io	576	6	Infections	infection	NNS
cord-296585-yfh5d4io	576	7	and	and	CC
cord-296585-yfh5d4io	576	8	airway	airway	NN
cord-296585-yfh5d4io	576	9	inflammation	inflammation	NN
cord-296585-yfh5d4io	576	10	in	in	IN
cord-296585-yfh5d4io	576	11	chronic	chronic	JJ
cord-296585-yfh5d4io	576	12	obstructive	obstructive	JJ
cord-296585-yfh5d4io	576	13	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	576	14	disease	disease	NN
cord-296585-yfh5d4io	576	15	severe	severe	JJ
cord-296585-yfh5d4io	576	16	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	576	17	Effect	effect	NN
cord-296585-yfh5d4io	576	18	of	of	IN
cord-296585-yfh5d4io	576	19	interactions	interaction	NNS
cord-296585-yfh5d4io	576	20	between	between	IN
cord-296585-yfh5d4io	576	21	lower	low	JJR
cord-296585-yfh5d4io	576	22	airway	airway	NN
cord-296585-yfh5d4io	576	23	bacterial	bacterial	JJ
cord-296585-yfh5d4io	576	24	and	and	CC
cord-296585-yfh5d4io	576	25	rhinoviral	rhinoviral	JJ
cord-296585-yfh5d4io	576	26	infection	infection	NN
cord-296585-yfh5d4io	576	27	in	in	IN
cord-296585-yfh5d4io	576	28	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	576	29	of	of	IN
cord-296585-yfh5d4io	576	30	COPD	COPD	NNP
cord-296585-yfh5d4io	576	31	Detection	Detection	NNP
cord-296585-yfh5d4io	576	32	of	of	IN
cord-296585-yfh5d4io	576	33	multiple	multiple	JJ
cord-296585-yfh5d4io	576	34	viral	viral	JJ
cord-296585-yfh5d4io	576	35	and	and	CC
cord-296585-yfh5d4io	576	36	bacterial	bacterial	JJ
cord-296585-yfh5d4io	576	37	infections	infection	NNS
cord-296585-yfh5d4io	576	38	in	in	IN
cord-296585-yfh5d4io	576	39	acute	acute	JJ
cord-296585-yfh5d4io	576	40	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	576	41	of	of	IN
cord-296585-yfh5d4io	576	42	chronic	chronic	JJ
cord-296585-yfh5d4io	576	43	obstructive	obstructive	JJ
cord-296585-yfh5d4io	576	44	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	576	45	disease	disease	NN
cord-296585-yfh5d4io	576	46	:	:	:
cord-296585-yfh5d4io	576	47	a	a	DT
cord-296585-yfh5d4io	576	48	pilot	pilot	NN
cord-296585-yfh5d4io	576	49	prospective	prospective	JJ
cord-296585-yfh5d4io	576	50	study	study	NN
cord-296585-yfh5d4io	576	51	Serum	serum	NN
cord-296585-yfh5d4io	576	52	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	576	53	biomarkers	biomarker	NNS
cord-296585-yfh5d4io	576	54	and	and	CC
cord-296585-yfh5d4io	576	55	clinical	clinical	JJ
cord-296585-yfh5d4io	576	56	outcomes	outcome	NNS
cord-296585-yfh5d4io	576	57	of	of	IN
cord-296585-yfh5d4io	576	58	COPD	COPD	NNP
cord-296585-yfh5d4io	576	59	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	576	60	caused	cause	VBN
cord-296585-yfh5d4io	576	61	by	by	IN
cord-296585-yfh5d4io	576	62	different	different	JJ
cord-296585-yfh5d4io	576	63	pathogens	pathogen	NNS
cord-296585-yfh5d4io	576	64	Antibacterial	antibacterial	JJ
cord-296585-yfh5d4io	576	65	defense	defense	NN
cord-296585-yfh5d4io	576	66	of	of	IN
cord-296585-yfh5d4io	576	67	human	human	JJ
cord-296585-yfh5d4io	576	68	airway	airway	NN
cord-296585-yfh5d4io	576	69	epithelial	epithelial	JJ
cord-296585-yfh5d4io	576	70	cells	cell	NNS
cord-296585-yfh5d4io	576	71	from	from	IN
cord-296585-yfh5d4io	576	72	chronic	chronic	JJ
cord-296585-yfh5d4io	576	73	obstructive	obstructive	JJ
cord-296585-yfh5d4io	576	74	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	576	75	disease	disease	NN
cord-296585-yfh5d4io	576	76	patients	patient	NNS
cord-296585-yfh5d4io	576	77	induced	induce	VBN
cord-296585-yfh5d4io	576	78	by	by	IN
cord-296585-yfh5d4io	576	79	acute	acute	JJ
cord-296585-yfh5d4io	576	80	exposure	exposure	NN
cord-296585-yfh5d4io	576	81	to	to	IN
cord-296585-yfh5d4io	576	82	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	576	83	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	576	84	influenzae	influenzae	NN
cord-296585-yfh5d4io	576	85	:	:	:
cord-296585-yfh5d4io	576	86	modulation	modulation	NN
cord-296585-yfh5d4io	576	87	by	by	IN
cord-296585-yfh5d4io	576	88	cigarette	cigarette	NN
cord-296585-yfh5d4io	576	89	smoke	smoke	NN
cord-296585-yfh5d4io	576	90	Effects	effect	NNS
cord-296585-yfh5d4io	576	91	of	of	IN
cord-296585-yfh5d4io	576	92	bacterial	bacterial	JJ
cord-296585-yfh5d4io	576	93	infection	infection	NN
cord-296585-yfh5d4io	576	94	on	on	IN
cord-296585-yfh5d4io	576	95	airway	airway	NN
cord-296585-yfh5d4io	576	96	antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	576	97	peptides	peptide	NNS
cord-296585-yfh5d4io	576	98	and	and	CC
cord-296585-yfh5d4io	576	99	proteins	protein	NNS
cord-296585-yfh5d4io	576	100	in	in	IN
cord-296585-yfh5d4io	576	101	COPD	COPD	NNP
cord-296585-yfh5d4io	576	102	Phagocytic	Phagocytic	NNP
cord-296585-yfh5d4io	576	103	dysfunction	dysfunction	NN
cord-296585-yfh5d4io	576	104	of	of	IN
cord-296585-yfh5d4io	576	105	human	human	JJ
cord-296585-yfh5d4io	576	106	alveolar	alveolar	NN
cord-296585-yfh5d4io	576	107	macrophages	macrophage	NNS
cord-296585-yfh5d4io	576	108	and	and	CC
cord-296585-yfh5d4io	576	109	severity	severity	NN
cord-296585-yfh5d4io	576	110	of	of	IN
cord-296585-yfh5d4io	576	111	chronic	chronic	JJ
cord-296585-yfh5d4io	576	112	obstructive	obstructive	JJ
cord-296585-yfh5d4io	576	113	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	576	114	disease	disease	NN
cord-296585-yfh5d4io	576	115	Defective	defective	JJ
cord-296585-yfh5d4io	576	116	macrophage	macrophage	NN
cord-296585-yfh5d4io	576	117	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	576	118	of	of	IN
cord-296585-yfh5d4io	576	119	bacteria	bacteria	NNS
cord-296585-yfh5d4io	576	120	in	in	IN
cord-296585-yfh5d4io	576	121	COPD	COPD	NNP
cord-296585-yfh5d4io	576	122	Behavioral	behavioral	JJ
cord-296585-yfh5d4io	576	123	and	and	CC
cord-296585-yfh5d4io	576	124	structural	structural	JJ
cord-296585-yfh5d4io	576	125	differences	difference	NNS
cord-296585-yfh5d4io	576	126	in	in	IN
cord-296585-yfh5d4io	576	127	migrating	migrate	VBG
cord-296585-yfh5d4io	576	128	peripheral	peripheral	JJ
cord-296585-yfh5d4io	576	129	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	576	130	from	from	IN
cord-296585-yfh5d4io	576	131	patients	patient	NNS
cord-296585-yfh5d4io	576	132	with	with	IN
cord-296585-yfh5d4io	576	133	chronic	chronic	JJ
cord-296585-yfh5d4io	576	134	obstructive	obstructive	JJ
cord-296585-yfh5d4io	576	135	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	576	136	disease	disease	NN
cord-296585-yfh5d4io	576	137	Bacterial	bacterial	JJ
cord-296585-yfh5d4io	576	138	microbiome	microbiome	NN
cord-296585-yfh5d4io	576	139	of	of	IN
cord-296585-yfh5d4io	576	140	lungs	lung	NNS
cord-296585-yfh5d4io	576	141	in	in	IN
cord-296585-yfh5d4io	576	142	COPD	COPD	NNP
cord-296585-yfh5d4io	577	1	New	new	JJ
cord-296585-yfh5d4io	577	2	opportunities	opportunity	NNS
cord-296585-yfh5d4io	577	3	for	for	IN
cord-296585-yfh5d4io	577	4	managing	manage	VBG
cord-296585-yfh5d4io	577	5	acute	acute	JJ
cord-296585-yfh5d4io	577	6	and	and	CC
cord-296585-yfh5d4io	577	7	chronic	chronic	JJ
cord-296585-yfh5d4io	577	8	lung	lung	NN
cord-296585-yfh5d4io	577	9	infections	infection	NNS
cord-296585-yfh5d4io	577	10	Role	role	NN
cord-296585-yfh5d4io	577	11	of	of	IN
cord-296585-yfh5d4io	577	12	the	the	DT
cord-296585-yfh5d4io	577	13	lung	lung	NN
cord-296585-yfh5d4io	577	14	microbiome	microbiome	NN
cord-296585-yfh5d4io	577	15	in	in	IN
cord-296585-yfh5d4io	577	16	the	the	DT
cord-296585-yfh5d4io	577	17	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	577	18	of	of	IN
cord-296585-yfh5d4io	577	19	chronic	chronic	JJ
cord-296585-yfh5d4io	577	20	obstructive	obstructive	JJ
cord-296585-yfh5d4io	577	21	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	577	22	disease	disease	NN
cord-296585-yfh5d4io	577	23	Airway	airway	NN
cord-296585-yfh5d4io	577	24	microbial	microbial	JJ
cord-296585-yfh5d4io	577	25	metagenomics	metagenomic	NNS
cord-296585-yfh5d4io	577	26	.	.	.
cord-296585-yfh5d4io	578	1	Microbes	microbe	NNS
cord-296585-yfh5d4io	578	2	Infect	infect	VBP
cord-296585-yfh5d4io	578	3	The	the	DT
cord-296585-yfh5d4io	578	4	consequence	consequence	NN
cord-296585-yfh5d4io	578	5	of	of	IN
cord-296585-yfh5d4io	578	6	matrix	matrix	NN
cord-296585-yfh5d4io	578	7	dysfunction	dysfunction	NN
cord-296585-yfh5d4io	578	8	on	on	IN
cord-296585-yfh5d4io	578	9	lung	lung	NN
cord-296585-yfh5d4io	578	10	immunity	immunity	NN
cord-296585-yfh5d4io	578	11	and	and	CC
cord-296585-yfh5d4io	578	12	the	the	DT
cord-296585-yfh5d4io	578	13	microbiome	microbiome	NN
cord-296585-yfh5d4io	578	14	in	in	IN
cord-296585-yfh5d4io	578	15	COPD	COPD	NNP
cord-296585-yfh5d4io	579	1	The	the	DT
cord-296585-yfh5d4io	579	2	lung	lung	NN
cord-296585-yfh5d4io	579	3	microbiome	microbiome	NN
cord-296585-yfh5d4io	579	4	,	,	,
cord-296585-yfh5d4io	579	5	immunity	immunity	NN
cord-296585-yfh5d4io	579	6	,	,	,
cord-296585-yfh5d4io	579	7	and	and	CC
cord-296585-yfh5d4io	579	8	the	the	DT
cord-296585-yfh5d4io	579	9	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	579	10	of	of	IN
cord-296585-yfh5d4io	579	11	chronic	chronic	JJ
cord-296585-yfh5d4io	579	12	lung	lung	NN
cord-296585-yfh5d4io	579	13	disease	disease	NN
cord-296585-yfh5d4io	579	14	Microbiome	Microbiome	NNP
cord-296585-yfh5d4io	579	15	in	in	IN
cord-296585-yfh5d4io	579	16	chronic	chronic	JJ
cord-296585-yfh5d4io	579	17	obstructive	obstructive	JJ
cord-296585-yfh5d4io	579	18	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	579	19	disease	disease	NN
cord-296585-yfh5d4io	579	20	Biological	biological	JJ
cord-296585-yfh5d4io	579	21	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	579	22	clusters	cluster	NNS
cord-296585-yfh5d4io	579	23	demonstrate	demonstrate	VBP
cord-296585-yfh5d4io	579	24	asthma	asthma	NN
cord-296585-yfh5d4io	579	25	and	and	CC
cord-296585-yfh5d4io	579	26	chronic	chronic	JJ
cord-296585-yfh5d4io	579	27	obstructive	obstructive	JJ
cord-296585-yfh5d4io	579	28	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	579	29	disease	disease	NN
cord-296585-yfh5d4io	579	30	overlap	overlap	VBP
cord-296585-yfh5d4io	579	31	with	with	IN
cord-296585-yfh5d4io	579	32	distinct	distinct	JJ
cord-296585-yfh5d4io	579	33	mediator	mediator	NN
cord-296585-yfh5d4io	579	34	and	and	CC
cord-296585-yfh5d4io	579	35	microbiome	microbiome	NN
cord-296585-yfh5d4io	579	36	profiles	profile	NNS
cord-296585-yfh5d4io	580	1	The	the	DT
cord-296585-yfh5d4io	580	2	transient	transient	JJ
cord-296585-yfh5d4io	580	3	but	but	CC
cord-296585-yfh5d4io	580	4	not	not	RB
cord-296585-yfh5d4io	580	5	resident	resident	JJ
cord-296585-yfh5d4io	580	6	(	(	-LRB-
cord-296585-yfh5d4io	580	7	TBNR	TBNR	NNP
cord-296585-yfh5d4io	580	8	)	)	-RRB-
cord-296585-yfh5d4io	580	9	microbiome	microbiome	NNP
cord-296585-yfh5d4io	580	10	:	:	:
cord-296585-yfh5d4io	580	11	a	a	DT
cord-296585-yfh5d4io	580	12	Yin	Yin	NNP
cord-296585-yfh5d4io	580	13	Yang	Yang	NNP
cord-296585-yfh5d4io	580	14	model	model	NN
cord-296585-yfh5d4io	580	15	for	for	IN
cord-296585-yfh5d4io	580	16	lung	lung	NN
cord-296585-yfh5d4io	580	17	immune	immune	NN
cord-296585-yfh5d4io	580	18	system	system	NN
cord-296585-yfh5d4io	580	19	Outgrowth	Outgrowth	NNP
cord-296585-yfh5d4io	580	20	of	of	IN
cord-296585-yfh5d4io	580	21	the	the	DT
cord-296585-yfh5d4io	580	22	bacterial	bacterial	JJ
cord-296585-yfh5d4io	580	23	airway	airway	NN
cord-296585-yfh5d4io	580	24	microbiome	microbiome	NN
cord-296585-yfh5d4io	580	25	after	after	IN
cord-296585-yfh5d4io	580	26	rhinovirus	rhinovirus	NN
cord-296585-yfh5d4io	580	27	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	580	28	of	of	IN
cord-296585-yfh5d4io	580	29	chronic	chronic	JJ
cord-296585-yfh5d4io	580	30	obstructive	obstructive	JJ
cord-296585-yfh5d4io	580	31	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	580	32	disease	disease	NN
cord-296585-yfh5d4io	580	33	Influence	influence	NN
cord-296585-yfh5d4io	580	34	of	of	IN
cord-296585-yfh5d4io	580	35	lung	lung	NN
cord-296585-yfh5d4io	580	36	CT	CT	NNP
cord-296585-yfh5d4io	580	37	changes	change	NNS
cord-296585-yfh5d4io	580	38	in	in	IN
cord-296585-yfh5d4io	580	39	chronic	chronic	JJ
cord-296585-yfh5d4io	580	40	obstructive	obstructive	JJ
cord-296585-yfh5d4io	580	41	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	580	42	disease	disease	NN
cord-296585-yfh5d4io	580	43	(	(	-LRB-
cord-296585-yfh5d4io	580	44	COPD	COPD	NNP
cord-296585-yfh5d4io	580	45	)	)	-RRB-
cord-296585-yfh5d4io	580	46	on	on	IN
cord-296585-yfh5d4io	580	47	the	the	DT
cord-296585-yfh5d4io	580	48	human	human	JJ
cord-296585-yfh5d4io	580	49	lung	lung	NN
cord-296585-yfh5d4io	580	50	microbiome	microbiome	NN
cord-296585-yfh5d4io	580	51	Comparing	compare	VBG
cord-296585-yfh5d4io	580	52	microbiota	microbiota	NN
cord-296585-yfh5d4io	580	53	profiles	profile	NNS
cord-296585-yfh5d4io	580	54	in	in	IN
cord-296585-yfh5d4io	580	55	induced	induced	JJ
cord-296585-yfh5d4io	580	56	and	and	CC
cord-296585-yfh5d4io	580	57	spontaneous	spontaneous	JJ
cord-296585-yfh5d4io	580	58	sputum	sputum	NN
cord-296585-yfh5d4io	580	59	samples	sample	NNS
cord-296585-yfh5d4io	580	60	in	in	IN
cord-296585-yfh5d4io	580	61	COPD	COPD	NNP
cord-296585-yfh5d4io	580	62	patients	patient	NNS
cord-296585-yfh5d4io	580	63	Characterization	characterization	NN
cord-296585-yfh5d4io	580	64	of	of	IN
cord-296585-yfh5d4io	580	65	throat	throat	NN
cord-296585-yfh5d4io	580	66	microbial	microbial	JJ
cord-296585-yfh5d4io	580	67	flora	flora	NNS
cord-296585-yfh5d4io	580	68	in	in	IN
cord-296585-yfh5d4io	580	69	smokers	smoker	NNS
cord-296585-yfh5d4io	580	70	with	with	IN
cord-296585-yfh5d4io	580	71	or	or	CC
cord-296585-yfh5d4io	580	72	without	without	IN
cord-296585-yfh5d4io	580	73	COPD	COPD	NNP
cord-296585-yfh5d4io	581	1	Severity	severity	NN
cord-296585-yfh5d4io	581	2	-	-	HYPH
cord-296585-yfh5d4io	581	3	related	relate	VBN
cord-296585-yfh5d4io	581	4	changes	change	NNS
cord-296585-yfh5d4io	581	5	of	of	IN
cord-296585-yfh5d4io	581	6	bronchial	bronchial	JJ
cord-296585-yfh5d4io	581	7	microbiome	microbiome	NN
cord-296585-yfh5d4io	581	8	in	in	IN
cord-296585-yfh5d4io	581	9	chronic	chronic	JJ
cord-296585-yfh5d4io	581	10	obstructive	obstructive	JJ
cord-296585-yfh5d4io	581	11	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	581	12	disease	disease	NN
cord-296585-yfh5d4io	581	13	Airway	airway	NN
cord-296585-yfh5d4io	581	14	microbiome	microbiome	NN
cord-296585-yfh5d4io	581	15	dynamics	dynamic	NNS
cord-296585-yfh5d4io	581	16	in	in	IN
cord-296585-yfh5d4io	581	17	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	581	18	of	of	IN
cord-296585-yfh5d4io	581	19	chronic	chronic	JJ
cord-296585-yfh5d4io	581	20	obstructive	obstructive	JJ
cord-296585-yfh5d4io	581	21	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	581	22	disease	disease	NN
cord-296585-yfh5d4io	581	23	Exacerbation	Exacerbation	NNP
cord-296585-yfh5d4io	581	24	induces	induce	VBZ
cord-296585-yfh5d4io	581	25	a	a	DT
cord-296585-yfh5d4io	581	26	microbiota	microbiota	NN
cord-296585-yfh5d4io	581	27	shift	shift	NN
cord-296585-yfh5d4io	581	28	in	in	IN
cord-296585-yfh5d4io	581	29	sputa	sputa	NN
cord-296585-yfh5d4io	581	30	of	of	IN
cord-296585-yfh5d4io	581	31	COPD	COPD	NNP
cord-296585-yfh5d4io	581	32	patients	patient	NNS
cord-296585-yfh5d4io	581	33	Microbiome	Microbiome	NNP
cord-296585-yfh5d4io	581	34	effects	effect	NNS
cord-296585-yfh5d4io	581	35	on	on	IN
cord-296585-yfh5d4io	581	36	immunity	immunity	NN
cord-296585-yfh5d4io	581	37	,	,	,
cord-296585-yfh5d4io	581	38	health	health	NN
cord-296585-yfh5d4io	581	39	and	and	CC
cord-296585-yfh5d4io	581	40	disease	disease	NN
cord-296585-yfh5d4io	581	41	in	in	IN
cord-296585-yfh5d4io	581	42	the	the	DT
cord-296585-yfh5d4io	581	43	lung	lung	NN
cord-296585-yfh5d4io	581	44	Neutrophil	Neutrophil	NNP
cord-296585-yfh5d4io	581	45	extracellular	extracellular	JJ
cord-296585-yfh5d4io	581	46	traps	trap	NNS
cord-296585-yfh5d4io	581	47	are	be	VBP
cord-296585-yfh5d4io	581	48	associated	associate	VBN
cord-296585-yfh5d4io	581	49	with	with	IN
cord-296585-yfh5d4io	581	50	disease	disease	NN
cord-296585-yfh5d4io	581	51	severity	severity	NN
cord-296585-yfh5d4io	581	52	and	and	CC
cord-296585-yfh5d4io	581	53	microbiota	microbiota	NN
cord-296585-yfh5d4io	581	54	diversity	diversity	NN
cord-296585-yfh5d4io	581	55	in	in	IN
cord-296585-yfh5d4io	581	56	patients	patient	NNS
cord-296585-yfh5d4io	581	57	with	with	IN
cord-296585-yfh5d4io	581	58	chronic	chronic	JJ
cord-296585-yfh5d4io	581	59	obstructive	obstructive	JJ
cord-296585-yfh5d4io	581	60	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	581	61	disease	disease	NN
cord-296585-yfh5d4io	581	62	Microbiota	Microbiota	NNP
cord-296585-yfh5d4io	581	63	promotes	promote	VBZ
cord-296585-yfh5d4io	581	64	chronic	chronic	JJ
cord-296585-yfh5d4io	581	65	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	581	66	inflammation	inflammation	NN
cord-296585-yfh5d4io	581	67	by	by	IN
cord-296585-yfh5d4io	581	68	enhancing	enhance	VBG
cord-296585-yfh5d4io	581	69	IL-17A	IL-17A	NNP
cord-296585-yfh5d4io	581	70	and	and	CC
cord-296585-yfh5d4io	581	71	autoantibodies	autoantibody	NNS
cord-296585-yfh5d4io	582	1	The	the	DT
cord-296585-yfh5d4io	582	2	lung	lung	NN
cord-296585-yfh5d4io	582	3	tissue	tissue	NN
cord-296585-yfh5d4io	582	4	microbiome	microbiome	NN
cord-296585-yfh5d4io	582	5	in	in	IN
cord-296585-yfh5d4io	582	6	chronic	chronic	JJ
cord-296585-yfh5d4io	582	7	obstructive	obstructive	JJ
cord-296585-yfh5d4io	582	8	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	582	9	disease	disease	NN
cord-296585-yfh5d4io	582	10	Host	Host	NNP
cord-296585-yfh5d4io	582	11	response	response	NN
cord-296585-yfh5d4io	582	12	to	to	IN
cord-296585-yfh5d4io	582	13	the	the	DT
cord-296585-yfh5d4io	582	14	lung	lung	NN
cord-296585-yfh5d4io	582	15	microbiome	microbiome	NN
cord-296585-yfh5d4io	582	16	in	in	IN
cord-296585-yfh5d4io	582	17	chronic	chronic	JJ
cord-296585-yfh5d4io	582	18	obstructive	obstructive	JJ
cord-296585-yfh5d4io	582	19	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	582	20	disease	disease	NN
cord-296585-yfh5d4io	582	21	Mannose	mannose	NN
cord-296585-yfh5d4io	582	22	-	-	HYPH
cord-296585-yfh5d4io	582	23	binding	bind	VBG
cord-296585-yfh5d4io	582	24	lectin	lectin	NN
cord-296585-yfh5d4io	582	25	deficiency	deficiency	NN
cord-296585-yfh5d4io	582	26	and	and	CC
cord-296585-yfh5d4io	582	27	disease	disease	NN
cord-296585-yfh5d4io	582	28	severity	severity	NN
cord-296585-yfh5d4io	582	29	in	in	IN
cord-296585-yfh5d4io	582	30	noncystic	noncystic	JJ
cord-296585-yfh5d4io	582	31	fibrosis	fibrosis	NN
cord-296585-yfh5d4io	582	32	bronchiectasis	bronchiectasis	NNP
cord-296585-yfh5d4io	582	33	:	:	:
cord-296585-yfh5d4io	582	34	a	a	DT
cord-296585-yfh5d4io	582	35	prospective	prospective	JJ
cord-296585-yfh5d4io	582	36	study	study	NN
cord-296585-yfh5d4io	582	37	Genetic	genetic	JJ
cord-296585-yfh5d4io	582	38	mannose	mannose	NN
cord-296585-yfh5d4io	582	39	binding	bind	VBG
cord-296585-yfh5d4io	582	40	lectin	lectin	NN
cord-296585-yfh5d4io	582	41	deficiency	deficiency	NN
cord-296585-yfh5d4io	582	42	is	be	VBZ
cord-296585-yfh5d4io	582	43	associated	associate	VBN
cord-296585-yfh5d4io	582	44	with	with	IN
cord-296585-yfh5d4io	582	45	airway	airway	NN
cord-296585-yfh5d4io	582	46	microbiota	microbiota	NN
cord-296585-yfh5d4io	582	47	diversity	diversity	NN
cord-296585-yfh5d4io	582	48	and	and	CC
cord-296585-yfh5d4io	582	49	reduced	reduce	VBN
cord-296585-yfh5d4io	582	50	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	582	51	frequency	frequency	NN
cord-296585-yfh5d4io	582	52	in	in	IN
cord-296585-yfh5d4io	582	53	COPD	COPD	NNP
cord-296585-yfh5d4io	582	54	JTD	JTD	NNP
cord-296585-yfh5d4io	582	55	special	special	JJ
cord-296585-yfh5d4io	582	56	edition	edition	NN
cord-296585-yfh5d4io	582	57	'	'	``
cord-296585-yfh5d4io	582	58	Hot	hot	JJ
cord-296585-yfh5d4io	582	59	topics	topic	NNS
cord-296585-yfh5d4io	582	60	in	in	IN
cord-296585-yfh5d4io	582	61	COPD'-the	COPD'-the	NNP
cord-296585-yfh5d4io	582	62	microbiome	microbiome	NN
cord-296585-yfh5d4io	582	63	in	in	IN
cord-296585-yfh5d4io	582	64	COPD	COPD	NNP
cord-296585-yfh5d4io	582	65	Analysis	Analysis	NNP
cord-296585-yfh5d4io	582	66	of	of	IN
cord-296585-yfh5d4io	582	67	the	the	DT
cord-296585-yfh5d4io	582	68	lung	lung	NN
cord-296585-yfh5d4io	582	69	microbiome	microbiome	NN
cord-296585-yfh5d4io	582	70	in	in	IN
cord-296585-yfh5d4io	582	71	the	the	DT
cord-296585-yfh5d4io	582	72	"	"	``
cord-296585-yfh5d4io	582	73	healthy	healthy	JJ
cord-296585-yfh5d4io	582	74	"	"	''
cord-296585-yfh5d4io	582	75	smoker	smoker	NN
cord-296585-yfh5d4io	582	76	and	and	CC
cord-296585-yfh5d4io	582	77	in	in	IN
cord-296585-yfh5d4io	582	78	COPD	COPD	NNP
cord-296585-yfh5d4io	582	79	Disordered	disordered	JJ
cord-296585-yfh5d4io	582	80	microbial	microbial	JJ
cord-296585-yfh5d4io	582	81	communities	community	NNS
cord-296585-yfh5d4io	582	82	in	in	IN
cord-296585-yfh5d4io	582	83	asthmatic	asthmatic	JJ
cord-296585-yfh5d4io	582	84	airways	airway	NNS
cord-296585-yfh5d4io	582	85	Insights	insight	NNS
cord-296585-yfh5d4io	582	86	on	on	IN
cord-296585-yfh5d4io	582	87	persistent	persistent	JJ
cord-296585-yfh5d4io	582	88	airway	airway	NN
cord-296585-yfh5d4io	582	89	infection	infection	NN
cord-296585-yfh5d4io	582	90	by	by	IN
cord-296585-yfh5d4io	582	91	non	non	JJ
cord-296585-yfh5d4io	582	92	-	-	JJ
cord-296585-yfh5d4io	582	93	typeable	typeable	JJ
cord-296585-yfh5d4io	582	94	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	582	95	influenzae	influenzae	NN
cord-296585-yfh5d4io	582	96	in	in	IN
cord-296585-yfh5d4io	582	97	chronic	chronic	JJ
cord-296585-yfh5d4io	582	98	obstructive	obstructive	JJ
cord-296585-yfh5d4io	582	99	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	582	100	disease	disease	NN
cord-296585-yfh5d4io	582	101	Non	non	JJ
cord-296585-yfh5d4io	582	102	-	-	JJ
cord-296585-yfh5d4io	582	103	typeable	typeable	JJ
cord-296585-yfh5d4io	582	104	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	582	105	influenzae	influenzae	NN
cord-296585-yfh5d4io	582	106	,	,	,
cord-296585-yfh5d4io	582	107	an	an	DT
cord-296585-yfh5d4io	582	108	under	under	RB
cord-296585-yfh5d4io	582	109	-	-	HYPH
cord-296585-yfh5d4io	582	110	recognised	recognise	VBN
cord-296585-yfh5d4io	582	111	pathogen	pathogen	NN
cord-296585-yfh5d4io	582	112	Clinical	clinical	JJ
cord-296585-yfh5d4io	582	113	and	and	CC
cord-296585-yfh5d4io	582	114	molecular	molecular	JJ
cord-296585-yfh5d4io	582	115	epidemiology	epidemiology	NN
cord-296585-yfh5d4io	582	116	of	of	IN
cord-296585-yfh5d4io	582	117	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	582	118	influenzae	influenzae	NN
cord-296585-yfh5d4io	582	119	causing	cause	VBG
cord-296585-yfh5d4io	582	120	invasive	invasive	JJ
cord-296585-yfh5d4io	582	121	disease	disease	NN
cord-296585-yfh5d4io	582	122	in	in	IN
cord-296585-yfh5d4io	582	123	adult	adult	NN
cord-296585-yfh5d4io	582	124	patients	patient	NNS
cord-296585-yfh5d4io	582	125	Invasive	invasive	JJ
cord-296585-yfh5d4io	582	126	disease	disease	NN
cord-296585-yfh5d4io	582	127	caused	cause	VBN
cord-296585-yfh5d4io	582	128	by	by	IN
cord-296585-yfh5d4io	582	129	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	582	130	influenzae	influenzae	NN
cord-296585-yfh5d4io	582	131	in	in	IN
cord-296585-yfh5d4io	582	132	Sweden	Sweden	NNP
cord-296585-yfh5d4io	582	133	1997	1997	CD
cord-296585-yfh5d4io	582	134	-	-	SYM
cord-296585-yfh5d4io	582	135	2009	2009	CD
cord-296585-yfh5d4io	582	136	;	;	:
cord-296585-yfh5d4io	582	137	evidence	evidence	NN
cord-296585-yfh5d4io	582	138	of	of	IN
cord-296585-yfh5d4io	582	139	increasing	increase	VBG
cord-296585-yfh5d4io	582	140	incidence	incidence	NN
cord-296585-yfh5d4io	582	141	and	and	CC
cord-296585-yfh5d4io	582	142	clinical	clinical	JJ
cord-296585-yfh5d4io	582	143	burden	burden	NN
cord-296585-yfh5d4io	582	144	of	of	IN
cord-296585-yfh5d4io	582	145	non	non	JJ
cord-296585-yfh5d4io	582	146	-	-	JJ
cord-296585-yfh5d4io	582	147	type	type	JJ
cord-296585-yfh5d4io	582	148	b	b	NN
cord-296585-yfh5d4io	582	149	strains	strain	VBZ
cord-296585-yfh5d4io	582	150	Invasive	invasive	JJ
cord-296585-yfh5d4io	582	151	disease	disease	NN
cord-296585-yfh5d4io	582	152	caused	cause	VBN
cord-296585-yfh5d4io	582	153	by	by	IN
cord-296585-yfh5d4io	582	154	Nontypeable	Nontypeable	NNP
cord-296585-yfh5d4io	582	155	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	582	156	influenzae	influenzae	NN
cord-296585-yfh5d4io	582	157	Nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	582	158	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	582	159	influenzae	influenzae	NN
cord-296585-yfh5d4io	582	160	and	and	CC
cord-296585-yfh5d4io	582	161	chronic	chronic	JJ
cord-296585-yfh5d4io	582	162	obstructive	obstructive	JJ
cord-296585-yfh5d4io	582	163	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	582	164	disease	disease	NN
cord-296585-yfh5d4io	582	165	:	:	:
cord-296585-yfh5d4io	582	166	a	a	DT
cord-296585-yfh5d4io	582	167	review	review	NN
cord-296585-yfh5d4io	582	168	for	for	IN
cord-296585-yfh5d4io	582	169	clinicians	clinician	NNS
cord-296585-yfh5d4io	582	170	Optimal	Optimal	NNP
cord-296585-yfh5d4io	582	171	sampling	sampling	NN
cord-296585-yfh5d4io	582	172	sites	site	NNS
cord-296585-yfh5d4io	582	173	and	and	CC
cord-296585-yfh5d4io	582	174	methods	method	NNS
cord-296585-yfh5d4io	582	175	for	for	IN
cord-296585-yfh5d4io	582	176	detection	detection	NN
cord-296585-yfh5d4io	582	177	of	of	IN
cord-296585-yfh5d4io	582	178	pathogens	pathogen	NNS
cord-296585-yfh5d4io	582	179	possibly	possibly	RB
cord-296585-yfh5d4io	582	180	causing	cause	VBG
cord-296585-yfh5d4io	582	181	community	community	NN
cord-296585-yfh5d4io	582	182	-	-	HYPH
cord-296585-yfh5d4io	582	183	acquired	acquire	VBN
cord-296585-yfh5d4io	582	184	lower	low	JJR
cord-296585-yfh5d4io	582	185	respiratory	respiratory	JJ
cord-296585-yfh5d4io	582	186	tract	tract	NN
cord-296585-yfh5d4io	582	187	infections	infection	NNS
cord-296585-yfh5d4io	583	1	The	the	DT
cord-296585-yfh5d4io	583	2	role	role	NN
cord-296585-yfh5d4io	583	3	of	of	IN
cord-296585-yfh5d4io	583	4	the	the	DT
cord-296585-yfh5d4io	583	5	microbiome	microbiome	NN
cord-296585-yfh5d4io	583	6	in	in	IN
cord-296585-yfh5d4io	583	7	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	583	8	of	of	IN
cord-296585-yfh5d4io	583	9	chronic	chronic	JJ
cord-296585-yfh5d4io	583	10	lung	lung	NN
cord-296585-yfh5d4io	583	11	diseases	disease	NNS
cord-296585-yfh5d4io	583	12	Lung	Lung	NNP
cord-296585-yfh5d4io	583	13	microbiology	microbiology	NN
cord-296585-yfh5d4io	583	14	and	and	CC
cord-296585-yfh5d4io	583	15	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	583	16	in	in	IN
cord-296585-yfh5d4io	583	17	COPD	COPD	NNP
cord-296585-yfh5d4io	584	1	Airway	airway	JJ
cord-296585-yfh5d4io	584	2	inflammation	inflammation	NN
cord-296585-yfh5d4io	584	3	and	and	CC
cord-296585-yfh5d4io	584	4	bronchial	bronchial	JJ
cord-296585-yfh5d4io	584	5	bacterial	bacterial	JJ
cord-296585-yfh5d4io	584	6	colonization	colonization	NN
cord-296585-yfh5d4io	584	7	in	in	IN
cord-296585-yfh5d4io	584	8	chronic	chronic	JJ
cord-296585-yfh5d4io	584	9	obstructive	obstructive	JJ
cord-296585-yfh5d4io	584	10	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	584	11	disease	disease	NN
cord-296585-yfh5d4io	584	12	Nontypeable	Nontypeable	NNP
cord-296585-yfh5d4io	584	13	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	584	14	influenzae	influenzae	NN
cord-296585-yfh5d4io	584	15	in	in	IN
cord-296585-yfh5d4io	584	16	the	the	DT
cord-296585-yfh5d4io	584	17	lower	low	JJR
cord-296585-yfh5d4io	584	18	respiratory	respiratory	JJ
cord-296585-yfh5d4io	584	19	tract	tract	NN
cord-296585-yfh5d4io	584	20	of	of	IN
cord-296585-yfh5d4io	584	21	patients	patient	NNS
cord-296585-yfh5d4io	584	22	with	with	IN
cord-296585-yfh5d4io	584	23	chronic	chronic	JJ
cord-296585-yfh5d4io	584	24	bronchitis	bronchitis	NN
cord-296585-yfh5d4io	584	25	Bronchial	bronchial	JJ
cord-296585-yfh5d4io	584	26	microbiome	microbiome	NN
cord-296585-yfh5d4io	584	27	of	of	IN
cord-296585-yfh5d4io	584	28	severe	severe	JJ
cord-296585-yfh5d4io	584	29	COPD	COPD	NNP
cord-296585-yfh5d4io	584	30	patients	patient	NNS
cord-296585-yfh5d4io	584	31	colonised	colonise	VBN
cord-296585-yfh5d4io	584	32	by	by	IN
cord-296585-yfh5d4io	584	33	Pseudomonas	Pseudomonas	NNP
cord-296585-yfh5d4io	584	34	aeruginosa	aeruginosa	VBZ
cord-296585-yfh5d4io	584	35	Lower	low	JJR
cord-296585-yfh5d4io	584	36	airway	airway	NN
cord-296585-yfh5d4io	584	37	colonization	colonization	NN
cord-296585-yfh5d4io	584	38	and	and	CC
cord-296585-yfh5d4io	584	39	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	584	40	response	response	NN
cord-296585-yfh5d4io	584	41	in	in	IN
cord-296585-yfh5d4io	584	42	COPD	COPD	NNP
cord-296585-yfh5d4io	584	43	:	:	:
cord-296585-yfh5d4io	584	44	a	a	DT
cord-296585-yfh5d4io	584	45	focus	focus	NN
cord-296585-yfh5d4io	584	46	on	on	IN
cord-296585-yfh5d4io	584	47	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	584	48	influenzae	influenzae	NN
cord-296585-yfh5d4io	584	49	Differential	differential	JJ
cord-296585-yfh5d4io	584	50	adaptation	adaptation	NN
cord-296585-yfh5d4io	584	51	of	of	IN
cord-296585-yfh5d4io	584	52	microbial	microbial	JJ
cord-296585-yfh5d4io	584	53	pathogens	pathogen	NNS
cord-296585-yfh5d4io	584	54	to	to	IN
cord-296585-yfh5d4io	584	55	airways	airway	NNS
cord-296585-yfh5d4io	584	56	of	of	IN
cord-296585-yfh5d4io	584	57	patients	patient	NNS
cord-296585-yfh5d4io	584	58	with	with	IN
cord-296585-yfh5d4io	584	59	cystic	cystic	JJ
cord-296585-yfh5d4io	584	60	fibrosis	fibrosis	NN
cord-296585-yfh5d4io	584	61	and	and	CC
cord-296585-yfh5d4io	584	62	chronic	chronic	JJ
cord-296585-yfh5d4io	584	63	obstructive	obstructive	JJ
cord-296585-yfh5d4io	584	64	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	584	65	disease	disease	NN
cord-296585-yfh5d4io	584	66	Bacterial	bacterial	JJ
cord-296585-yfh5d4io	584	67	adaptation	adaptation	NN
cord-296585-yfh5d4io	584	68	during	during	IN
cord-296585-yfh5d4io	584	69	chronic	chronic	JJ
cord-296585-yfh5d4io	584	70	respiratory	respiratory	JJ
cord-296585-yfh5d4io	584	71	infections	infection	NNS
cord-296585-yfh5d4io	584	72	Nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	584	73	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	584	74	influenzae	influenzae	NN
cord-296585-yfh5d4io	584	75	genetic	genetic	JJ
cord-296585-yfh5d4io	584	76	islands	island	NNS
cord-296585-yfh5d4io	584	77	associated	associate	VBN
cord-296585-yfh5d4io	584	78	with	with	IN
cord-296585-yfh5d4io	584	79	chronic	chronic	JJ
cord-296585-yfh5d4io	584	80	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	584	81	infection	infection	NN
cord-296585-yfh5d4io	584	82	Proteomic	Proteomic	NNP
cord-296585-yfh5d4io	584	83	expression	expression	NN
cord-296585-yfh5d4io	584	84	profiling	profiling	NN
cord-296585-yfh5d4io	584	85	of	of	IN
cord-296585-yfh5d4io	584	86	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	584	87	influenzae	influenzae	NN
cord-296585-yfh5d4io	584	88	grown	grow	VBN
cord-296585-yfh5d4io	584	89	in	in	IN
cord-296585-yfh5d4io	584	90	pooled	pool	VBN
cord-296585-yfh5d4io	584	91	human	human	JJ
cord-296585-yfh5d4io	584	92	sputum	sputum	NN
cord-296585-yfh5d4io	584	93	from	from	IN
cord-296585-yfh5d4io	584	94	adults	adult	NNS
cord-296585-yfh5d4io	584	95	with	with	IN
cord-296585-yfh5d4io	584	96	chronic	chronic	JJ
cord-296585-yfh5d4io	584	97	obstructive	obstructive	JJ
cord-296585-yfh5d4io	584	98	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	584	99	disease	disease	NN
cord-296585-yfh5d4io	584	100	reveal	reveal	VB
cord-296585-yfh5d4io	584	101	antioxidant	antioxidant	NN
cord-296585-yfh5d4io	584	102	and	and	CC
cord-296585-yfh5d4io	584	103	stress	stress	NN
cord-296585-yfh5d4io	584	104	responses	response	NNS
cord-296585-yfh5d4io	585	1	Genome	genome	NN
cord-296585-yfh5d4io	585	2	-	-	HYPH
cord-296585-yfh5d4io	585	3	wide	wide	JJ
cord-296585-yfh5d4io	585	4	fitness	fitness	NN
cord-296585-yfh5d4io	585	5	profiling	profiling	NN
cord-296585-yfh5d4io	585	6	reveals	reveal	VBZ
cord-296585-yfh5d4io	585	7	adaptations	adaptation	NNS
cord-296585-yfh5d4io	585	8	required	require	VBN
cord-296585-yfh5d4io	585	9	by	by	IN
cord-296585-yfh5d4io	585	10	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	585	11	in	in	IN
cord-296585-yfh5d4io	585	12	coinfection	coinfection	NN
cord-296585-yfh5d4io	585	13	with	with	IN
cord-296585-yfh5d4io	585	14	influenza	influenza	NN
cord-296585-yfh5d4io	585	15	A	a	DT
cord-296585-yfh5d4io	585	16	virus	virus	NN
cord-296585-yfh5d4io	585	17	in	in	IN
cord-296585-yfh5d4io	585	18	the	the	DT
cord-296585-yfh5d4io	585	19	murine	murine	JJ
cord-296585-yfh5d4io	585	20	lung	lung	NN
cord-296585-yfh5d4io	585	21	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	585	22	influenzae	influenzae	NN
cord-296585-yfh5d4io	586	1	genome	genome	NN
cord-296585-yfh5d4io	586	2	evolution	evolution	NN
cord-296585-yfh5d4io	586	3	during	during	IN
cord-296585-yfh5d4io	586	4	persistence	persistence	NN
cord-296585-yfh5d4io	586	5	in	in	IN
cord-296585-yfh5d4io	586	6	the	the	DT
cord-296585-yfh5d4io	586	7	human	human	JJ
cord-296585-yfh5d4io	586	8	airways	airway	NNS
cord-296585-yfh5d4io	586	9	in	in	IN
cord-296585-yfh5d4io	586	10	chronic	chronic	JJ
cord-296585-yfh5d4io	586	11	obstructive	obstructive	JJ
cord-296585-yfh5d4io	586	12	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	586	13	disease	disease	NN
cord-296585-yfh5d4io	586	14	Expression	Expression	NNP
cord-296585-yfh5d4io	586	15	of	of	IN
cord-296585-yfh5d4io	586	16	IgA	IgA	NNP
cord-296585-yfh5d4io	586	17	proteases	protease	NNS
cord-296585-yfh5d4io	586	18	by	by	IN
cord-296585-yfh5d4io	586	19	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	586	20	influenzae	influenzae	NN
cord-296585-yfh5d4io	586	21	in	in	IN
cord-296585-yfh5d4io	586	22	the	the	DT
cord-296585-yfh5d4io	586	23	respiratory	respiratory	JJ
cord-296585-yfh5d4io	586	24	tract	tract	NN
cord-296585-yfh5d4io	586	25	of	of	IN
cord-296585-yfh5d4io	586	26	adults	adult	NNS
cord-296585-yfh5d4io	586	27	with	with	IN
cord-296585-yfh5d4io	586	28	chronic	chronic	JJ
cord-296585-yfh5d4io	586	29	obstructive	obstructive	JJ
cord-296585-yfh5d4io	586	30	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	586	31	disease	disease	NN
cord-296585-yfh5d4io	587	1	Immunoglobulin	immunoglobulin	NN
cord-296585-yfh5d4io	587	2	A	a	DT
cord-296585-yfh5d4io	587	3	protease	protease	NN
cord-296585-yfh5d4io	587	4	variants	variant	NNS
cord-296585-yfh5d4io	587	5	facilitate	facilitate	VBP
cord-296585-yfh5d4io	587	6	intracellular	intracellular	JJ
cord-296585-yfh5d4io	587	7	survival	survival	NN
cord-296585-yfh5d4io	587	8	in	in	IN
cord-296585-yfh5d4io	587	9	epithelial	epithelial	JJ
cord-296585-yfh5d4io	587	10	cells	cell	NNS
cord-296585-yfh5d4io	587	11	by	by	IN
cord-296585-yfh5d4io	587	12	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	587	13	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	587	14	influenzae	influenzae	NN
cord-296585-yfh5d4io	587	15	that	that	WDT
cord-296585-yfh5d4io	587	16	persist	persist	VBP
cord-296585-yfh5d4io	587	17	in	in	IN
cord-296585-yfh5d4io	587	18	the	the	DT
cord-296585-yfh5d4io	587	19	human	human	JJ
cord-296585-yfh5d4io	587	20	respiratory	respiratory	JJ
cord-296585-yfh5d4io	587	21	tract	tract	NN
cord-296585-yfh5d4io	587	22	in	in	IN
cord-296585-yfh5d4io	587	23	chronic	chronic	JJ
cord-296585-yfh5d4io	587	24	obstructive	obstructive	JJ
cord-296585-yfh5d4io	587	25	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	587	26	disease	disease	NN
cord-296585-yfh5d4io	587	27	Changes	change	NNS
cord-296585-yfh5d4io	587	28	in	in	IN
cord-296585-yfh5d4io	587	29	IgA	IgA	NNP
cord-296585-yfh5d4io	587	30	protease	protease	NN
cord-296585-yfh5d4io	587	31	expression	expression	NN
cord-296585-yfh5d4io	587	32	are	be	VBP
cord-296585-yfh5d4io	587	33	conferred	confer	VBN
cord-296585-yfh5d4io	587	34	by	by	IN
cord-296585-yfh5d4io	587	35	changes	change	NNS
cord-296585-yfh5d4io	587	36	in	in	IN
cord-296585-yfh5d4io	587	37	genomes	genome	NNS
cord-296585-yfh5d4io	587	38	during	during	IN
cord-296585-yfh5d4io	587	39	persistent	persistent	JJ
cord-296585-yfh5d4io	587	40	infection	infection	NN
cord-296585-yfh5d4io	587	41	by	by	IN
cord-296585-yfh5d4io	587	42	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	587	43	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	587	44	influenzae	influenzae	NN
cord-296585-yfh5d4io	587	45	in	in	IN
cord-296585-yfh5d4io	587	46	chronic	chronic	JJ
cord-296585-yfh5d4io	587	47	obstructive	obstructive	JJ
cord-296585-yfh5d4io	587	48	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	587	49	disease	disease	NN
cord-296585-yfh5d4io	587	50	Increased	increase	VBN
cord-296585-yfh5d4io	587	51	biofilm	biofilm	NN
cord-296585-yfh5d4io	587	52	formation	formation	NN
cord-296585-yfh5d4io	587	53	by	by	IN
cord-296585-yfh5d4io	587	54	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	587	55	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	587	56	influenzae	influenzae	NN
cord-296585-yfh5d4io	587	57	isolates	isolate	VBZ
cord-296585-yfh5d4io	587	58	from	from	IN
cord-296585-yfh5d4io	587	59	patients	patient	NNS
cord-296585-yfh5d4io	587	60	with	with	IN
cord-296585-yfh5d4io	587	61	invasive	invasive	JJ
cord-296585-yfh5d4io	587	62	disease	disease	NN
cord-296585-yfh5d4io	587	63	or	or	CC
cord-296585-yfh5d4io	587	64	otitis	otitis	NN
cord-296585-yfh5d4io	587	65	media	medium	NNS
cord-296585-yfh5d4io	587	66	versus	versus	IN
cord-296585-yfh5d4io	587	67	strains	strain	NNS
cord-296585-yfh5d4io	587	68	recovered	recover	VBN
cord-296585-yfh5d4io	587	69	from	from	IN
cord-296585-yfh5d4io	587	70	cases	case	NNS
cord-296585-yfh5d4io	587	71	of	of	IN
cord-296585-yfh5d4io	587	72	respiratory	respiratory	JJ
cord-296585-yfh5d4io	587	73	infections	infection	NNS
cord-296585-yfh5d4io	587	74	Nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	587	75	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	587	76	influenzae	influenzae	NN
cord-296585-yfh5d4io	587	77	biofilms	biofilm	NNS
cord-296585-yfh5d4io	587	78	:	:	:
cord-296585-yfh5d4io	587	79	role	role	NN
cord-296585-yfh5d4io	587	80	in	in	IN
cord-296585-yfh5d4io	587	81	chronic	chronic	JJ
cord-296585-yfh5d4io	587	82	airway	airway	NN
cord-296585-yfh5d4io	587	83	infections	infection	NNS
cord-296585-yfh5d4io	587	84	Nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	587	85	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	587	86	influenzae	influenzae	NN
cord-296585-yfh5d4io	587	87	(	(	-LRB-
cord-296585-yfh5d4io	587	88	NTHi	NTHi	NNS
cord-296585-yfh5d4io	587	89	)	)	-RRB-
cord-296585-yfh5d4io	587	90	directly	directly	RB
cord-296585-yfh5d4io	587	91	interfere	interfere	VB
cord-296585-yfh5d4io	587	92	with	with	IN
cord-296585-yfh5d4io	587	93	the	the	DT
cord-296585-yfh5d4io	587	94	regulation	regulation	NN
cord-296585-yfh5d4io	587	95	of	of	IN
cord-296585-yfh5d4io	587	96	E	e	NN
cord-296585-yfh5d4io	587	97	-	-	NN
cord-296585-yfh5d4io	587	98	cadherin	cadherin	NN
cord-296585-yfh5d4io	587	99	in	in	IN
cord-296585-yfh5d4io	587	100	lung	lung	NN
cord-296585-yfh5d4io	587	101	epithelial	epithelial	JJ
cord-296585-yfh5d4io	587	102	cells	cell	NNS
cord-296585-yfh5d4io	587	103	.	.	.
cord-296585-yfh5d4io	588	1	Microbes	microbe	NNS
cord-296585-yfh5d4io	588	2	Infect	infect	VBP
cord-296585-yfh5d4io	588	3	Human	human	JJ
cord-296585-yfh5d4io	588	4	pathogens	pathogen	NNS
cord-296585-yfh5d4io	588	5	utilize	utilize	VBP
cord-296585-yfh5d4io	588	6	host	host	NN
cord-296585-yfh5d4io	588	7	extracellular	extracellular	JJ
cord-296585-yfh5d4io	588	8	matrix	matrix	NN
cord-296585-yfh5d4io	588	9	proteins	protein	NNS
cord-296585-yfh5d4io	588	10	laminin	laminin	NN
cord-296585-yfh5d4io	588	11	and	and	CC
cord-296585-yfh5d4io	588	12	collagen	collagen	NN
cord-296585-yfh5d4io	588	13	for	for	IN
cord-296585-yfh5d4io	588	14	adhesion	adhesion	NN
cord-296585-yfh5d4io	588	15	and	and	CC
cord-296585-yfh5d4io	588	16	invasion	invasion	NN
cord-296585-yfh5d4io	588	17	of	of	IN
cord-296585-yfh5d4io	588	18	the	the	DT
cord-296585-yfh5d4io	588	19	host	host	NN
cord-296585-yfh5d4io	588	20	Inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	588	21	thresholds	threshold	NNS
cord-296585-yfh5d4io	588	22	and	and	CC
cord-296585-yfh5d4io	588	23	the	the	DT
cord-296585-yfh5d4io	588	24	species	species	NN
cord-296585-yfh5d4io	588	25	-	-	HYPH
cord-296585-yfh5d4io	588	26	specific	specific	JJ
cord-296585-yfh5d4io	588	27	effects	effect	NNS
cord-296585-yfh5d4io	588	28	of	of	IN
cord-296585-yfh5d4io	588	29	colonising	colonise	VBG
cord-296585-yfh5d4io	588	30	bacteria	bacteria	NNS
cord-296585-yfh5d4io	588	31	in	in	IN
cord-296585-yfh5d4io	589	1	stable	stable	JJ
cord-296585-yfh5d4io	589	2	chronic	chronic	JJ
cord-296585-yfh5d4io	589	3	obstructive	obstructive	JJ
cord-296585-yfh5d4io	589	4	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	589	5	disease	disease	NN
cord-296585-yfh5d4io	589	6	NF	nf	NN
cord-296585-yfh5d4io	589	7	-	-	HYPH
cord-296585-yfh5d4io	589	8	κB	κB	NNP
cord-296585-yfh5d4io	589	9	signaling	signal	VBG
cord-296585-yfh5d4io	589	10	in	in	IN
cord-296585-yfh5d4io	589	11	inflammation	inflammation	NN
cord-296585-yfh5d4io	590	1	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	590	2	influenzae	influenzae	NN
cord-296585-yfh5d4io	590	3	lysate	lysate	NN
cord-296585-yfh5d4io	590	4	induces	induce	VBZ
cord-296585-yfh5d4io	590	5	aspects	aspect	NNS
cord-296585-yfh5d4io	590	6	of	of	IN
cord-296585-yfh5d4io	590	7	the	the	DT
cord-296585-yfh5d4io	590	8	chronic	chronic	JJ
cord-296585-yfh5d4io	590	9	obstructive	obstructive	JJ
cord-296585-yfh5d4io	590	10	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	590	11	disease	disease	NN
cord-296585-yfh5d4io	590	12	phenotype	phenotype	NN
cord-296585-yfh5d4io	591	1	Combined	combined	JJ
cord-296585-yfh5d4io	591	2	exposure	exposure	NN
cord-296585-yfh5d4io	591	3	to	to	IN
cord-296585-yfh5d4io	592	1	cigarette	cigarette	NN
cord-296585-yfh5d4io	592	2	smoke	smoke	NN
cord-296585-yfh5d4io	592	3	and	and	CC
cord-296585-yfh5d4io	592	4	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	592	5	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	592	6	influenzae	influenzae	NN
cord-296585-yfh5d4io	592	7	drives	drive	VBZ
cord-296585-yfh5d4io	592	8	development	development	NN
cord-296585-yfh5d4io	592	9	of	of	IN
cord-296585-yfh5d4io	592	10	a	a	DT
cord-296585-yfh5d4io	592	11	COPD	COPD	NNP
cord-296585-yfh5d4io	592	12	phenotype	phenotype	NN
cord-296585-yfh5d4io	592	13	in	in	IN
cord-296585-yfh5d4io	593	1	mice	mouse	NNS
cord-296585-yfh5d4io	593	2	Cigarette	Cigarette	NNP
cord-296585-yfh5d4io	593	3	smokeinduced	smokeinduce	VBD
cord-296585-yfh5d4io	593	4	lung	lung	NN
cord-296585-yfh5d4io	593	5	disease	disease	NN
cord-296585-yfh5d4io	593	6	predisposes	predispose	VBZ
cord-296585-yfh5d4io	593	7	to	to	IN
cord-296585-yfh5d4io	593	8	more	more	RBR
cord-296585-yfh5d4io	593	9	severe	severe	JJ
cord-296585-yfh5d4io	593	10	infection	infection	NN
cord-296585-yfh5d4io	593	11	with	with	IN
cord-296585-yfh5d4io	593	12	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	593	13	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	593	14	influenzae	influenzae	NN
cord-296585-yfh5d4io	593	15	:	:	:
cord-296585-yfh5d4io	593	16	protective	protective	JJ
cord-296585-yfh5d4io	593	17	effects	effect	NNS
cord-296585-yfh5d4io	593	18	of	of	IN
cord-296585-yfh5d4io	593	19	andrographolide	andrographolide	NN
cord-296585-yfh5d4io	593	20	The	the	DT
cord-296585-yfh5d4io	593	21	Role	role	NN
cord-296585-yfh5d4io	593	22	of	of	IN
cord-296585-yfh5d4io	593	23	TLR2	TLR2	NNP
cord-296585-yfh5d4io	593	24	in	in	IN
cord-296585-yfh5d4io	593	25	infection	infection	NN
cord-296585-yfh5d4io	593	26	and	and	CC
cord-296585-yfh5d4io	593	27	immunity	immunity	NN
cord-296585-yfh5d4io	593	28	Toll	toll	NN
cord-296585-yfh5d4io	593	29	-	-	HYPH
cord-296585-yfh5d4io	593	30	like	like	JJ
cord-296585-yfh5d4io	593	31	receptor	receptor	NN
cord-296585-yfh5d4io	593	32	signaling	signal	VBG
cord-296585-yfh5d4io	593	33	pathways	pathway	NNS
cord-296585-yfh5d4io	594	1	A	a	DT
cord-296585-yfh5d4io	594	2	comparative	comparative	JJ
cord-296585-yfh5d4io	594	3	review	review	NN
cord-296585-yfh5d4io	594	4	of	of	IN
cord-296585-yfh5d4io	594	5	toll	toll	NN
cord-296585-yfh5d4io	594	6	-	-	HYPH
cord-296585-yfh5d4io	594	7	like	like	JJ
cord-296585-yfh5d4io	594	8	receptor	receptor	NN
cord-296585-yfh5d4io	594	9	4	4	CD
cord-296585-yfh5d4io	594	10	expression	expression	NN
cord-296585-yfh5d4io	594	11	and	and	CC
cord-296585-yfh5d4io	594	12	functionality	functionality	NN
cord-296585-yfh5d4io	594	13	in	in	IN
cord-296585-yfh5d4io	594	14	different	different	JJ
cord-296585-yfh5d4io	594	15	animal	animal	NN
cord-296585-yfh5d4io	594	16	species	specie	NNS
cord-296585-yfh5d4io	594	17	Outer	outer	JJ
cord-296585-yfh5d4io	594	18	membrane	membrane	NN
cord-296585-yfh5d4io	594	19	protein	protein	NN
cord-296585-yfh5d4io	594	20	P6	p6	NN
cord-296585-yfh5d4io	594	21	of	of	IN
cord-296585-yfh5d4io	594	22	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	594	23	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	594	24	influenzae	influenzae	NN
cord-296585-yfh5d4io	594	25	is	be	VBZ
cord-296585-yfh5d4io	594	26	a	a	DT
cord-296585-yfh5d4io	594	27	potent	potent	JJ
cord-296585-yfh5d4io	594	28	and	and	CC
cord-296585-yfh5d4io	594	29	selective	selective	JJ
cord-296585-yfh5d4io	594	30	inducer	inducer	NN
cord-296585-yfh5d4io	594	31	of	of	IN
cord-296585-yfh5d4io	594	32	human	human	JJ
cord-296585-yfh5d4io	594	33	macrophage	macrophage	NN
cord-296585-yfh5d4io	594	34	proinflammatory	proinflammatory	JJ
cord-296585-yfh5d4io	594	35	cytokines	cytokine	NNS
cord-296585-yfh5d4io	594	36	Activation	Activation	NNP
cord-296585-yfh5d4io	594	37	of	of	IN
cord-296585-yfh5d4io	594	38	NF	NF	NNP
cord-296585-yfh5d4io	594	39	-	-	HYPH
cord-296585-yfh5d4io	594	40	kappa	kappa	NN
cord-296585-yfh5d4io	594	41	B	B	NNP
cord-296585-yfh5d4io	594	42	by	by	IN
cord-296585-yfh5d4io	594	43	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	594	44	Hemophilus	Hemophilus	NNP
cord-296585-yfh5d4io	594	45	influenzae	influenzae	NN
cord-296585-yfh5d4io	594	46	is	be	VBZ
cord-296585-yfh5d4io	594	47	mediated	mediate	VBN
cord-296585-yfh5d4io	594	48	by	by	IN
cord-296585-yfh5d4io	594	49	toll	toll	NN
cord-296585-yfh5d4io	594	50	-	-	HYPH
cord-296585-yfh5d4io	594	51	like	like	JJ
cord-296585-yfh5d4io	594	52	receptor	receptor	NN
cord-296585-yfh5d4io	594	53	2-TAK1-dependent	2-tak1-dependent	CD
cord-296585-yfh5d4io	595	1	NIK	NIK	NNP
cord-296585-yfh5d4io	595	2	-	-	HYPH
cord-296585-yfh5d4io	595	3	IKK	IKK	NNP
cord-296585-yfh5d4io	595	4	alpha	alpha	NN
cord-296585-yfh5d4io	595	5	/beta	/beta	.
cord-296585-yfh5d4io	596	1	-I	-i	DT
cord-296585-yfh5d4io	596	2	kappa	kappa	NNP
cord-296585-yfh5d4io	596	3	B	B	NNP
cord-296585-yfh5d4io	596	4	alpha	alpha	NN
cord-296585-yfh5d4io	596	5	and	and	CC
cord-296585-yfh5d4io	596	6	MKK3/6-p38	MKK3/6-p38	NNP
cord-296585-yfh5d4io	596	7	MAP	MAP	NNP
cord-296585-yfh5d4io	596	8	kinase	kinase	NN
cord-296585-yfh5d4io	596	9	signaling	signal	VBG
cord-296585-yfh5d4io	596	10	pathways	pathway	NNS
cord-296585-yfh5d4io	596	11	in	in	IN
cord-296585-yfh5d4io	596	12	epithelial	epithelial	JJ
cord-296585-yfh5d4io	596	13	cells	cell	NNS
cord-296585-yfh5d4io	597	1	Toll	toll	NN
cord-296585-yfh5d4io	597	2	-	-	HYPH
cord-296585-yfh5d4io	597	3	like	like	JJ
cord-296585-yfh5d4io	597	4	receptor	receptor	NN
cord-296585-yfh5d4io	597	5	4	4	CD
cord-296585-yfh5d4io	597	6	mediates	mediate	VBZ
cord-296585-yfh5d4io	597	7	innate	innate	JJ
cord-296585-yfh5d4io	597	8	immune	immune	JJ
cord-296585-yfh5d4io	597	9	responses	response	NNS
cord-296585-yfh5d4io	597	10	to	to	IN
cord-296585-yfh5d4io	597	11	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	597	12	influenzae	influenzae	NN
cord-296585-yfh5d4io	597	13	infection	infection	NN
cord-296585-yfh5d4io	597	14	in	in	IN
cord-296585-yfh5d4io	597	15	mouse	mouse	NN
cord-296585-yfh5d4io	597	16	lung	lung	NN
cord-296585-yfh5d4io	598	1	The	the	DT
cord-296585-yfh5d4io	598	2	MyD88-dependent	MyD88-dependent	NNP
cord-296585-yfh5d4io	598	3	,	,	,
cord-296585-yfh5d4io	598	4	but	but	CC
cord-296585-yfh5d4io	598	5	not	not	RB
cord-296585-yfh5d4io	598	6	the	the	DT
cord-296585-yfh5d4io	598	7	MyD88-independent	MyD88-independent	NNP
cord-296585-yfh5d4io	598	8	,	,	,
cord-296585-yfh5d4io	598	9	pathway	pathway	NN
cord-296585-yfh5d4io	598	10	of	of	IN
cord-296585-yfh5d4io	598	11	TLR4	TLR4	NNP
cord-296585-yfh5d4io	598	12	signaling	signaling	NN
cord-296585-yfh5d4io	598	13	is	be	VBZ
cord-296585-yfh5d4io	598	14	important	important	JJ
cord-296585-yfh5d4io	598	15	in	in	IN
cord-296585-yfh5d4io	598	16	clearing	clear	VBG
cord-296585-yfh5d4io	598	17	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	598	18	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	598	19	influenzae	influenzae	NN
cord-296585-yfh5d4io	598	20	from	from	IN
cord-296585-yfh5d4io	598	21	the	the	DT
cord-296585-yfh5d4io	598	22	mouse	mouse	NN
cord-296585-yfh5d4io	598	23	lung	lung	NN
cord-296585-yfh5d4io	598	24	Nontypeable	Nontypeable	NNP
cord-296585-yfh5d4io	598	25	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	598	26	influenzae	influenzae	NN
cord-296585-yfh5d4io	598	27	induces	induce	VBZ
cord-296585-yfh5d4io	598	28	COX-2	COX-2	NNP
cord-296585-yfh5d4io	598	29	and	and	CC
cord-296585-yfh5d4io	598	30	PGE2	PGE2	NNP
cord-296585-yfh5d4io	598	31	expression	expression	NN
cord-296585-yfh5d4io	598	32	in	in	IN
cord-296585-yfh5d4io	598	33	lung	lung	NN
cord-296585-yfh5d4io	598	34	epithelial	epithelial	NN
cord-296585-yfh5d4io	598	35	cells	cell	NNS
cord-296585-yfh5d4io	598	36	via	via	IN
cord-296585-yfh5d4io	598	37	activation	activation	NN
cord-296585-yfh5d4io	598	38	of	of	IN
cord-296585-yfh5d4io	598	39	p38	p38	CD
cord-296585-yfh5d4io	598	40	MAPK	MAPK	NNP
cord-296585-yfh5d4io	598	41	and	and	CC
cord-296585-yfh5d4io	598	42	NF	nf	NN
cord-296585-yfh5d4io	598	43	-	-	HYPH
cord-296585-yfh5d4io	598	44	kappa	kappa	NN
cord-296585-yfh5d4io	598	45	B	b	NN
cord-296585-yfh5d4io	599	1	Beyond	beyond	IN
cord-296585-yfh5d4io	599	2	MyD88	MyD88	NNS
cord-296585-yfh5d4io	599	3	and	and	CC
cord-296585-yfh5d4io	599	4	TRIF	TRIF	NNP
cord-296585-yfh5d4io	599	5	Pathways	pathway	NNS
cord-296585-yfh5d4io	599	6	in	in	IN
cord-296585-yfh5d4io	599	7	Toll	Toll	NNP
cord-296585-yfh5d4io	599	8	-	-	HYPH
cord-296585-yfh5d4io	599	9	Like	like	JJ
cord-296585-yfh5d4io	599	10	Receptor	receptor	NN
cord-296585-yfh5d4io	599	11	Signaling	Signaling	NNP
cord-296585-yfh5d4io	599	12	Nontypeable	Nontypeable	NNP
cord-296585-yfh5d4io	600	1	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	600	2	influenzae	influenzae	NN
cord-296585-yfh5d4io	600	3	-	-	HYPH
cord-296585-yfh5d4io	600	4	promoted	promote	VBN
cord-296585-yfh5d4io	600	5	proliferation	proliferation	NN
cord-296585-yfh5d4io	600	6	of	of	IN
cord-296585-yfh5d4io	600	7	Kras	Kras	NNP
cord-296585-yfh5d4io	600	8	-	-	HYPH
cord-296585-yfh5d4io	600	9	induced	induce	VBN
cord-296585-yfh5d4io	600	10	early	early	JJ
cord-296585-yfh5d4io	600	11	adenomatous	adenomatous	JJ
cord-296585-yfh5d4io	600	12	lesions	lesion	NNS
cord-296585-yfh5d4io	600	13	is	be	VBZ
cord-296585-yfh5d4io	600	14	completely	completely	RB
cord-296585-yfh5d4io	600	15	dependent	dependent	JJ
cord-296585-yfh5d4io	600	16	on	on	IN
cord-296585-yfh5d4io	600	17	Toll	toll	NN
cord-296585-yfh5d4io	600	18	-	-	HYPH
cord-296585-yfh5d4io	600	19	like	like	JJ
cord-296585-yfh5d4io	600	20	receptor	receptor	NN
cord-296585-yfh5d4io	600	21	signaling	signal	VBG
cord-296585-yfh5d4io	600	22	Dectin-1	Dectin-1	NNP
cord-296585-yfh5d4io	600	23	is	be	VBZ
cord-296585-yfh5d4io	600	24	expressed	express	VBN
cord-296585-yfh5d4io	600	25	in	in	IN
cord-296585-yfh5d4io	600	26	human	human	JJ
cord-296585-yfh5d4io	600	27	lung	lung	NN
cord-296585-yfh5d4io	600	28	and	and	CC
cord-296585-yfh5d4io	600	29	mediates	mediate	VBZ
cord-296585-yfh5d4io	600	30	the	the	DT
cord-296585-yfh5d4io	600	31	proinflammatory	proinflammatory	JJ
cord-296585-yfh5d4io	600	32	immune	immune	JJ
cord-296585-yfh5d4io	600	33	response	response	NN
cord-296585-yfh5d4io	600	34	to	to	IN
cord-296585-yfh5d4io	600	35	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	600	36	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	600	37	influenza	influenza	NN
cord-296585-yfh5d4io	600	38	Activation	activation	NN
cord-296585-yfh5d4io	600	39	of	of	IN
cord-296585-yfh5d4io	600	40	epidermal	epidermal	JJ
cord-296585-yfh5d4io	600	41	growth	growth	NN
cord-296585-yfh5d4io	600	42	factor	factor	NN
cord-296585-yfh5d4io	600	43	receptor	receptor	NN
cord-296585-yfh5d4io	600	44	is	be	VBZ
cord-296585-yfh5d4io	600	45	required	require	VBN
cord-296585-yfh5d4io	600	46	for	for	IN
cord-296585-yfh5d4io	600	47	NTHiinduced	nthiinduced	JJ
cord-296585-yfh5d4io	600	48	NF	NF	NNP
cord-296585-yfh5d4io	600	49	-	-	HYPH
cord-296585-yfh5d4io	600	50	kappaB	kappaB	NNP
cord-296585-yfh5d4io	600	51	-	-	HYPH
cord-296585-yfh5d4io	600	52	dependent	dependent	JJ
cord-296585-yfh5d4io	600	53	inflammation	inflammation	NN
cord-296585-yfh5d4io	600	54	Epidermal	epidermal	JJ
cord-296585-yfh5d4io	600	55	growth	growth	NN
cord-296585-yfh5d4io	600	56	factor	factor	NN
cord-296585-yfh5d4io	600	57	receptor	receptor	NN
cord-296585-yfh5d4io	600	58	acts	act	VBZ
cord-296585-yfh5d4io	600	59	as	as	IN
cord-296585-yfh5d4io	600	60	a	a	DT
cord-296585-yfh5d4io	600	61	negative	negative	JJ
cord-296585-yfh5d4io	600	62	regulator	regulator	NN
cord-296585-yfh5d4io	600	63	for	for	IN
cord-296585-yfh5d4io	600	64	bacterium	bacterium	NN
cord-296585-yfh5d4io	600	65	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	600	66	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	600	67	influenzae	influenzae	NN
cord-296585-yfh5d4io	600	68	-	-	HYPH
cord-296585-yfh5d4io	600	69	induced	induce	VBN
cord-296585-yfh5d4io	600	70	Toll	toll	NN
cord-296585-yfh5d4io	600	71	-	-	HYPH
cord-296585-yfh5d4io	600	72	like	like	JJ
cord-296585-yfh5d4io	600	73	receptor	receptor	NN
cord-296585-yfh5d4io	600	74	2	2	CD
cord-296585-yfh5d4io	600	75	expression	expression	NN
cord-296585-yfh5d4io	600	76	via	via	IN
cord-296585-yfh5d4io	600	77	an	an	DT
cord-296585-yfh5d4io	600	78	Src	Src	NNP
cord-296585-yfh5d4io	600	79	-	-	HYPH
cord-296585-yfh5d4io	600	80	dependent	dependent	JJ
cord-296585-yfh5d4io	600	81	p38	p38	CD
cord-296585-yfh5d4io	600	82	mitogen	mitogen	NN
cord-296585-yfh5d4io	600	83	-	-	HYPH
cord-296585-yfh5d4io	600	84	activated	activate	VBN
cord-296585-yfh5d4io	600	85	protein	protein	NN
cord-296585-yfh5d4io	600	86	kinase	kinase	NN
cord-296585-yfh5d4io	600	87	signaling	signal	VBG
cord-296585-yfh5d4io	600	88	pathway	pathway	NN
cord-296585-yfh5d4io	600	89	Multiple	Multiple	NNP
cord-296585-yfh5d4io	600	90	TLRs	tlr	NNS
cord-296585-yfh5d4io	600	91	activate	activate	VBP
cord-296585-yfh5d4io	600	92	EGFR	EGFR	NNP
cord-296585-yfh5d4io	600	93	via	via	IN
cord-296585-yfh5d4io	600	94	a	a	DT
cord-296585-yfh5d4io	600	95	signaling	signal	VBG
cord-296585-yfh5d4io	600	96	cascade	cascade	NN
cord-296585-yfh5d4io	600	97	to	to	TO
cord-296585-yfh5d4io	600	98	produce	produce	VB
cord-296585-yfh5d4io	600	99	innate	innate	JJ
cord-296585-yfh5d4io	600	100	immune	immune	JJ
cord-296585-yfh5d4io	600	101	responses	response	NNS
cord-296585-yfh5d4io	600	102	in	in	IN
cord-296585-yfh5d4io	600	103	airway	airway	NN
cord-296585-yfh5d4io	600	104	epithelium	epithelium	NN
cord-296585-yfh5d4io	600	105	Nontypeable	Nontypeable	NNP
cord-296585-yfh5d4io	600	106	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	600	107	influenzae	influenzae	NN
cord-296585-yfh5d4io	600	108	infection	infection	NN
cord-296585-yfh5d4io	600	109	upregulates	upregulate	VBZ
cord-296585-yfh5d4io	600	110	the	the	DT
cord-296585-yfh5d4io	600	111	NLRP3	nlrp3	NN
cord-296585-yfh5d4io	600	112	inflammasome	inflammasome	NN
cord-296585-yfh5d4io	600	113	and	and	CC
cord-296585-yfh5d4io	600	114	leads	lead	VBZ
cord-296585-yfh5d4io	600	115	to	to	IN
cord-296585-yfh5d4io	600	116	caspase-1-dependent	caspase-1-dependent	JJ
cord-296585-yfh5d4io	600	117	secretion	secretion	NN
cord-296585-yfh5d4io	600	118	of	of	IN
cord-296585-yfh5d4io	600	119	interleukin-1β	interleukin-1β	NNP
cord-296585-yfh5d4io	600	120	-a	-a	HYPH
cord-296585-yfh5d4io	600	121	possible	possible	JJ
cord-296585-yfh5d4io	600	122	pathway	pathway	NN
cord-296585-yfh5d4io	600	123	of	of	IN
cord-296585-yfh5d4io	600	124	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	600	125	in	in	IN
cord-296585-yfh5d4io	600	126	COPD	COPD	NNP
cord-296585-yfh5d4io	600	127	Synergistic	synergistic	JJ
cord-296585-yfh5d4io	600	128	activation	activation	NN
cord-296585-yfh5d4io	600	129	of	of	IN
cord-296585-yfh5d4io	600	130	NF	NF	NNP
cord-296585-yfh5d4io	600	131	-	-	HYPH
cord-296585-yfh5d4io	600	132	kappaB	kappaB	NNP
cord-296585-yfh5d4io	600	133	by	by	IN
cord-296585-yfh5d4io	600	134	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	600	135	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	600	136	influenzae	influenzae	NN
cord-296585-yfh5d4io	600	137	and	and	CC
cord-296585-yfh5d4io	600	138	tumor	tumor	NN
cord-296585-yfh5d4io	600	139	necrosis	necrosis	NN
cord-296585-yfh5d4io	600	140	factor	factor	NN
cord-296585-yfh5d4io	601	1	alpha	alpha	NN
cord-296585-yfh5d4io	601	2	TGF-	TGF-	NNP
cord-296585-yfh5d4io	602	1	beta	beta	NN
cord-296585-yfh5d4io	602	2	induces	induce	VBZ
cord-296585-yfh5d4io	602	3	p65	p65	VBG
cord-296585-yfh5d4io	602	4	acetylation	acetylation	NN
cord-296585-yfh5d4io	602	5	to	to	TO
cord-296585-yfh5d4io	602	6	enhance	enhance	VB
cord-296585-yfh5d4io	603	1	bacteria	bacteria	NNS
cord-296585-yfh5d4io	603	2	-	-	HYPH
cord-296585-yfh5d4io	603	3	induced	induce	VBN
cord-296585-yfh5d4io	603	4	NF	nf	NN
cord-296585-yfh5d4io	603	5	-	-	HYPH
cord-296585-yfh5d4io	603	6	kappaB	kappaB	NNP
cord-296585-yfh5d4io	603	7	activation	activation	NN
cord-296585-yfh5d4io	603	8	Rhinovirus	Rhinovirus	NNP
cord-296585-yfh5d4io	603	9	-	-	HYPH
cord-296585-yfh5d4io	603	10	bacteria	bacteria	NNS
cord-296585-yfh5d4io	603	11	coexposure	coexposure	NN
cord-296585-yfh5d4io	603	12	synergistically	synergistically	RB
cord-296585-yfh5d4io	603	13	induces	induce	VBZ
cord-296585-yfh5d4io	603	14	CCL20	ccl20	IN
cord-296585-yfh5d4io	603	15	production	production	NN
cord-296585-yfh5d4io	603	16	from	from	IN
cord-296585-yfh5d4io	603	17	human	human	JJ
cord-296585-yfh5d4io	603	18	bronchial	bronchial	JJ
cord-296585-yfh5d4io	603	19	epithelial	epithelial	JJ
cord-296585-yfh5d4io	603	20	cells	cell	NNS
cord-296585-yfh5d4io	603	21	Nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	603	22	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	603	23	influenzae	influenzae	NN
cord-296585-yfh5d4io	603	24	clearance	clearance	NN
cord-296585-yfh5d4io	603	25	by	by	IN
cord-296585-yfh5d4io	603	26	alveolar	alveolar	JJ
cord-296585-yfh5d4io	603	27	macrophages	macrophage	NNS
cord-296585-yfh5d4io	603	28	is	be	VBZ
cord-296585-yfh5d4io	603	29	impaired	impair	VBN
cord-296585-yfh5d4io	603	30	by	by	IN
cord-296585-yfh5d4io	603	31	exposure	exposure	NN
cord-296585-yfh5d4io	603	32	to	to	IN
cord-296585-yfh5d4io	603	33	cigarette	cigarette	NN
cord-296585-yfh5d4io	603	34	smoke	smoke	NN
cord-296585-yfh5d4io	603	35	Synergistic	synergistic	JJ
cord-296585-yfh5d4io	603	36	effect	effect	NN
cord-296585-yfh5d4io	603	37	of	of	IN
cord-296585-yfh5d4io	603	38	interleukin	interleukin	NN
cord-296585-yfh5d4io	603	39	1	1	CD
cord-296585-yfh5d4io	603	40	alpha	alpha	NN
cord-296585-yfh5d4io	603	41	on	on	IN
cord-296585-yfh5d4io	603	42	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	603	43	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	603	44	influenzae	influenzae	NN
cord-296585-yfh5d4io	603	45	-	-	HYPH
cord-296585-yfh5d4io	603	46	induced	induce	VBN
cord-296585-yfh5d4io	603	47	upregulation	upregulation	NN
cord-296585-yfh5d4io	603	48	of	of	IN
cord-296585-yfh5d4io	603	49	human	human	JJ
cord-296585-yfh5d4io	603	50	beta	beta	NN
cord-296585-yfh5d4io	603	51	-	-	HYPH
cord-296585-yfh5d4io	603	52	defensin	defensin	NN
cord-296585-yfh5d4io	603	53	2	2	CD
cord-296585-yfh5d4io	603	54	in	in	IN
cord-296585-yfh5d4io	603	55	middle	middle	JJ
cord-296585-yfh5d4io	603	56	ear	ear	NN
cord-296585-yfh5d4io	603	57	epithelial	epithelial	JJ
cord-296585-yfh5d4io	603	58	cells	cell	NNS
cord-296585-yfh5d4io	603	59	Activation	activation	NN
cord-296585-yfh5d4io	603	60	of	of	IN
cord-296585-yfh5d4io	603	61	a	a	DT
cord-296585-yfh5d4io	603	62	Src	Src	NNP
cord-296585-yfh5d4io	603	63	-	-	HYPH
cord-296585-yfh5d4io	603	64	dependent	dependent	JJ
cord-296585-yfh5d4io	603	65	Raf	Raf	NNP
cord-296585-yfh5d4io	603	66	-	-	:
cord-296585-yfh5d4io	603	67	MEK1/2-ERK	MEK1/2-ERK	NNP
cord-296585-yfh5d4io	603	68	signaling	signal	VBG
cord-296585-yfh5d4io	603	69	pathway	pathway	NN
cord-296585-yfh5d4io	603	70	is	be	VBZ
cord-296585-yfh5d4io	603	71	required	require	VBN
cord-296585-yfh5d4io	603	72	for	for	IN
cord-296585-yfh5d4io	603	73	IL-1alpha	il-1alpha	JJ
cord-296585-yfh5d4io	603	74	-	-	HYPH
cord-296585-yfh5d4io	603	75	induced	induce	VBN
cord-296585-yfh5d4io	603	76	upregulation	upregulation	NN
cord-296585-yfh5d4io	603	77	of	of	IN
cord-296585-yfh5d4io	603	78	beta	beta	JJ
cord-296585-yfh5d4io	603	79	-	-	HYPH
cord-296585-yfh5d4io	603	80	defensin	defensin	NNS
cord-296585-yfh5d4io	603	81	2	2	CD
cord-296585-yfh5d4io	603	82	in	in	IN
cord-296585-yfh5d4io	603	83	human	human	JJ
cord-296585-yfh5d4io	603	84	middle	middle	JJ
cord-296585-yfh5d4io	603	85	ear	ear	NN
cord-296585-yfh5d4io	603	86	epithelial	epithelial	JJ
cord-296585-yfh5d4io	603	87	cells	cell	NNS
cord-296585-yfh5d4io	603	88	Macrophages	macrophage	NNS
cord-296585-yfh5d4io	603	89	and	and	CC
cord-296585-yfh5d4io	603	90	polymorphonuclear	polymorphonuclear	JJ
cord-296585-yfh5d4io	603	91	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	603	92	in	in	IN
cord-296585-yfh5d4io	603	93	lung	lung	NN
cord-296585-yfh5d4io	603	94	defense	defense	NN
cord-296585-yfh5d4io	603	95	and	and	CC
cord-296585-yfh5d4io	603	96	injury	injury	NN
cord-296585-yfh5d4io	603	97	Lung	Lung	NNP
cord-296585-yfh5d4io	603	98	macrophage	macrophage	NN
cord-296585-yfh5d4io	603	99	phenotypes	phenotype	NNS
cord-296585-yfh5d4io	603	100	and	and	CC
cord-296585-yfh5d4io	603	101	functional	functional	JJ
cord-296585-yfh5d4io	603	102	responses	response	NNS
cord-296585-yfh5d4io	603	103	:	:	:
cord-296585-yfh5d4io	603	104	Role	role	NN
cord-296585-yfh5d4io	603	105	in	in	IN
cord-296585-yfh5d4io	603	106	the	the	DT
cord-296585-yfh5d4io	603	107	pathogenesis	pathogenesis	NN
cord-296585-yfh5d4io	603	108	of	of	IN
cord-296585-yfh5d4io	603	109	COPD	COPD	NNP
cord-296585-yfh5d4io	603	110	Neutrophils	Neutrophils	NNP
cord-296585-yfh5d4io	603	111	:	:	:
cord-296585-yfh5d4io	603	112	between	between	IN
cord-296585-yfh5d4io	603	113	host	host	NN
cord-296585-yfh5d4io	603	114	defence	defence	NN
cord-296585-yfh5d4io	603	115	,	,	,
cord-296585-yfh5d4io	603	116	immune	immune	JJ
cord-296585-yfh5d4io	603	117	modulation	modulation	NN
cord-296585-yfh5d4io	603	118	,	,	,
cord-296585-yfh5d4io	603	119	and	and	CC
cord-296585-yfh5d4io	603	120	tissue	tissue	NN
cord-296585-yfh5d4io	603	121	injury	injury	NN
cord-296585-yfh5d4io	604	1	How	how	WRB
cord-296585-yfh5d4io	604	2	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	604	3	kill	kill	VBP
cord-296585-yfh5d4io	604	4	microbes	microbe	NNS
cord-296585-yfh5d4io	604	5	Nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	604	6	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	604	7	influenzae	influenzae	NN
cord-296585-yfh5d4io	604	8	induces	induce	VBZ
cord-296585-yfh5d4io	604	9	sustained	sustain	VBD
cord-296585-yfh5d4io	604	10	lung	lung	NN
cord-296585-yfh5d4io	604	11	oxidative	oxidative	JJ
cord-296585-yfh5d4io	604	12	stress	stress	NN
cord-296585-yfh5d4io	604	13	and	and	CC
cord-296585-yfh5d4io	605	1	protease	protease	NN
cord-296585-yfh5d4io	605	2	expression	expression	NN
cord-296585-yfh5d4io	605	3	Nontypeable	Nontypeable	NNP
cord-296585-yfh5d4io	605	4	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	605	5	influenzae	influenzae	NN
cord-296585-yfh5d4io	605	6	initiates	initiate	VBZ
cord-296585-yfh5d4io	605	7	formation	formation	NN
cord-296585-yfh5d4io	605	8	of	of	IN
cord-296585-yfh5d4io	605	9	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	605	10	extracellular	extracellular	JJ
cord-296585-yfh5d4io	605	11	traps	trap	NNS
cord-296585-yfh5d4io	606	1	Matrix	matrix	NN
cord-296585-yfh5d4io	606	2	metalloproteinases	metalloproteinase	NNS
cord-296585-yfh5d4io	606	3	in	in	IN
cord-296585-yfh5d4io	606	4	destructive	destructive	JJ
cord-296585-yfh5d4io	606	5	lung	lung	NN
cord-296585-yfh5d4io	606	6	disease	disease	NN
cord-296585-yfh5d4io	606	7	Oxidative	oxidative	JJ
cord-296585-yfh5d4io	606	8	stress	stress	NN
cord-296585-yfh5d4io	606	9	in	in	IN
cord-296585-yfh5d4io	606	10	COPD	COPD	NNP
cord-296585-yfh5d4io	606	11	:	:	:
cord-296585-yfh5d4io	606	12	sources	source	NNS
cord-296585-yfh5d4io	606	13	,	,	,
cord-296585-yfh5d4io	606	14	markers	marker	NNS
cord-296585-yfh5d4io	606	15	,	,	,
cord-296585-yfh5d4io	606	16	and	and	CC
cord-296585-yfh5d4io	606	17	potential	potential	JJ
cord-296585-yfh5d4io	606	18	mechanisms	mechanism	NNS
cord-296585-yfh5d4io	606	19	Oxidative	oxidative	JJ
cord-296585-yfh5d4io	606	20	stress	stress	NN
cord-296585-yfh5d4io	606	21	in	in	IN
cord-296585-yfh5d4io	606	22	the	the	DT
cord-296585-yfh5d4io	606	23	lung	lung	NN
cord-296585-yfh5d4io	606	24	-the	-the	DT
cord-296585-yfh5d4io	606	25	essential	essential	JJ
cord-296585-yfh5d4io	606	26	paradox	paradox	NN
cord-296585-yfh5d4io	607	1	Adaptive	adaptive	JJ
cord-296585-yfh5d4io	607	2	immunity	immunity	NN
cord-296585-yfh5d4io	607	3	to	to	IN
cord-296585-yfh5d4io	607	4	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	607	5	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	607	6	influenzae	influenzae	NN
cord-296585-yfh5d4io	607	7	Effect	effect	NN
cord-296585-yfh5d4io	607	8	of	of	IN
cord-296585-yfh5d4io	607	9	interferon	interferon	NN
cord-296585-yfh5d4io	607	10	gamma	gamma	NN
cord-296585-yfh5d4io	607	11	and	and	CC
cord-296585-yfh5d4io	607	12	CD40	CD40	NNP
cord-296585-yfh5d4io	607	13	ligation	ligation	NN
cord-296585-yfh5d4io	607	14	on	on	IN
cord-296585-yfh5d4io	607	15	intracellular	intracellular	JJ
cord-296585-yfh5d4io	607	16	monocyte	monocyte	JJ
cord-296585-yfh5d4io	607	17	survival	survival	NN
cord-296585-yfh5d4io	607	18	of	of	IN
cord-296585-yfh5d4io	607	19	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	607	20	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	607	21	influenzae	influenzae	NN
cord-296585-yfh5d4io	608	1	Lung	Lung	NNP
cord-296585-yfh5d4io	608	2	T	t	NN
cord-296585-yfh5d4io	608	3	-	-	HYPH
cord-296585-yfh5d4io	608	4	cell	cell	NN
cord-296585-yfh5d4io	608	5	responses	response	NNS
cord-296585-yfh5d4io	608	6	to	to	IN
cord-296585-yfh5d4io	608	7	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	608	8	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	608	9	influenzae	influenzae	NN
cord-296585-yfh5d4io	608	10	in	in	IN
cord-296585-yfh5d4io	608	11	patients	patient	NNS
cord-296585-yfh5d4io	608	12	with	with	IN
cord-296585-yfh5d4io	608	13	chronic	chronic	JJ
cord-296585-yfh5d4io	608	14	obstructive	obstructive	JJ
cord-296585-yfh5d4io	608	15	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	608	16	disease	disease	NN
cord-296585-yfh5d4io	608	17	Nontypeable	Nontypeable	NNP
cord-296585-yfh5d4io	608	18	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	608	19	influenzae	influenzae	NN
cord-296585-yfh5d4io	608	20	DNA	dna	NN
cord-296585-yfh5d4io	608	21	stimulates	stimulate	VBZ
cord-296585-yfh5d4io	608	22	type	type	NN
cord-296585-yfh5d4io	608	23	I	-PRON-	PRP
cord-296585-yfh5d4io	609	1	interferon	interferon	JJ
cord-296585-yfh5d4io	609	2	expression	expression	NN
cord-296585-yfh5d4io	609	3	via	via	IN
cord-296585-yfh5d4io	609	4	STING	sting	NN
cord-296585-yfh5d4io	609	5	signaling	signal	VBG
cord-296585-yfh5d4io	609	6	pathway	pathway	NN
cord-296585-yfh5d4io	609	7	T	t	NN
cord-296585-yfh5d4io	609	8	-	-	HYPH
cord-296585-yfh5d4io	609	9	regulatory	regulatory	JJ
cord-296585-yfh5d4io	609	10	cells	cell	NNS
cord-296585-yfh5d4io	609	11	and	and	CC
cord-296585-yfh5d4io	609	12	programmed	program	VBD
cord-296585-yfh5d4io	609	13	death	death	NN
cord-296585-yfh5d4io	609	14	1	1	CD
cord-296585-yfh5d4io	610	1	+	+	CC
cord-296585-yfh5d4io	610	2	T	t	NN
cord-296585-yfh5d4io	610	3	cells	cell	NNS
cord-296585-yfh5d4io	610	4	contribute	contribute	VBP
cord-296585-yfh5d4io	610	5	to	to	TO
cord-296585-yfh5d4io	610	6	effector	effector	VB
cord-296585-yfh5d4io	610	7	T	t	NN
cord-296585-yfh5d4io	610	8	-	-	HYPH
cord-296585-yfh5d4io	610	9	cell	cell	NN
cord-296585-yfh5d4io	610	10	dysfunction	dysfunction	NN
cord-296585-yfh5d4io	610	11	in	in	IN
cord-296585-yfh5d4io	610	12	patients	patient	NNS
cord-296585-yfh5d4io	610	13	with	with	IN
cord-296585-yfh5d4io	610	14	chronic	chronic	JJ
cord-296585-yfh5d4io	610	15	obstructive	obstructive	JJ
cord-296585-yfh5d4io	610	16	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	610	17	disease	disease	NN
cord-296585-yfh5d4io	611	1	The	the	DT
cord-296585-yfh5d4io	611	2	role	role	NN
cord-296585-yfh5d4io	611	3	of	of	IN
cord-296585-yfh5d4io	611	4	regulatory	regulatory	JJ
cord-296585-yfh5d4io	611	5	T	t	NN
cord-296585-yfh5d4io	611	6	cell	cell	NN
cord-296585-yfh5d4io	611	7	in	in	IN
cord-296585-yfh5d4io	611	8	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	611	9	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	611	10	influenzae	influenzae	NN
cord-296585-yfh5d4io	611	11	-	-	HYPH
cord-296585-yfh5d4io	611	12	induced	induce	VBN
cord-296585-yfh5d4io	611	13	acute	acute	JJ
cord-296585-yfh5d4io	611	14	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	611	15	of	of	IN
cord-296585-yfh5d4io	611	16	chronic	chronic	JJ
cord-296585-yfh5d4io	611	17	obstructive	obstructive	JJ
cord-296585-yfh5d4io	611	18	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	611	19	disease	disease	NN
cord-296585-yfh5d4io	611	20	Earlylife	Earlylife	NNP
cord-296585-yfh5d4io	611	21	intranasal	intranasal	NN
cord-296585-yfh5d4io	611	22	colonization	colonization	NN
cord-296585-yfh5d4io	611	23	with	with	IN
cord-296585-yfh5d4io	611	24	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	611	25	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	611	26	influenzae	influenzae	NN
cord-296585-yfh5d4io	611	27	exacerbates	exacerbate	VBZ
cord-296585-yfh5d4io	611	28	juvenile	juvenile	JJ
cord-296585-yfh5d4io	611	29	airway	airway	NN
cord-296585-yfh5d4io	611	30	disease	disease	NN
cord-296585-yfh5d4io	611	31	in	in	IN
cord-296585-yfh5d4io	611	32	mice	mouse	NNS
cord-296585-yfh5d4io	611	33	Lymphocyte	Lymphocyte	NNP
cord-296585-yfh5d4io	611	34	proliferative	proliferative	JJ
cord-296585-yfh5d4io	611	35	response	response	NN
cord-296585-yfh5d4io	611	36	to	to	IN
cord-296585-yfh5d4io	611	37	P6	p6	NN
cord-296585-yfh5d4io	611	38	of	of	IN
cord-296585-yfh5d4io	611	39	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	611	40	influenzae	influenzae	NN
cord-296585-yfh5d4io	611	41	is	be	VBZ
cord-296585-yfh5d4io	611	42	associated	associate	VBN
cord-296585-yfh5d4io	611	43	with	with	IN
cord-296585-yfh5d4io	611	44	relative	relative	JJ
cord-296585-yfh5d4io	611	45	protection	protection	NN
cord-296585-yfh5d4io	611	46	from	from	IN
cord-296585-yfh5d4io	611	47	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	611	48	of	of	IN
cord-296585-yfh5d4io	611	49	chronic	chronic	JJ
cord-296585-yfh5d4io	611	50	obstructive	obstructive	JJ
cord-296585-yfh5d4io	611	51	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	611	52	disease	disease	NN
cord-296585-yfh5d4io	611	53	Steroid	Steroid	NNP
cord-296585-yfh5d4io	611	54	-	-	HYPH
cord-296585-yfh5d4io	611	55	induced	induce	VBN
cord-296585-yfh5d4io	611	56	deficiency	deficiency	NN
cord-296585-yfh5d4io	611	57	of	of	IN
cord-296585-yfh5d4io	611	58	mucosal	mucosal	NN
cord-296585-yfh5d4io	611	59	-	-	HYPH
cord-296585-yfh5d4io	611	60	associated	associated	JJ
cord-296585-yfh5d4io	611	61	invariant	invariant	JJ
cord-296585-yfh5d4io	611	62	T	t	NN
cord-296585-yfh5d4io	611	63	cells	cell	NNS
cord-296585-yfh5d4io	611	64	in	in	IN
cord-296585-yfh5d4io	611	65	the	the	DT
cord-296585-yfh5d4io	611	66	chronic	chronic	JJ
cord-296585-yfh5d4io	611	67	obstructive	obstructive	JJ
cord-296585-yfh5d4io	611	68	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	611	69	disease	disease	NN
cord-296585-yfh5d4io	611	70	lung	lung	NN
cord-296585-yfh5d4io	611	71	.	.	.
cord-296585-yfh5d4io	612	1	Implications	implication	NNS
cord-296585-yfh5d4io	612	2	for	for	IN
cord-296585-yfh5d4io	612	3	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	612	4	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	612	5	influenzae	influenzae	NN
cord-296585-yfh5d4io	612	6	Infection	infection	NN
cord-296585-yfh5d4io	613	1	Inhaled	inhale	VBN
cord-296585-yfh5d4io	613	2	corticosteroids	corticosteroid	NNS
cord-296585-yfh5d4io	613	3	in	in	IN
cord-296585-yfh5d4io	613	4	chronic	chronic	JJ
cord-296585-yfh5d4io	613	5	obstructive	obstructive	JJ
cord-296585-yfh5d4io	613	6	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	613	7	disease	disease	NN
cord-296585-yfh5d4io	613	8	.	.	.
cord-296585-yfh5d4io	614	1	A	a	DT
cord-296585-yfh5d4io	614	2	two	two	CD
cord-296585-yfh5d4io	614	3	-	-	HYPH
cord-296585-yfh5d4io	614	4	edged	edged	JJ
cord-296585-yfh5d4io	614	5	sword	sword	NN
cord-296585-yfh5d4io	614	6	Recognition	recognition	NN
cord-296585-yfh5d4io	614	7	of	of	IN
cord-296585-yfh5d4io	614	8	conserved	conserved	JJ
cord-296585-yfh5d4io	614	9	antigens	antigen	NNS
cord-296585-yfh5d4io	614	10	by	by	IN
cord-296585-yfh5d4io	614	11	Th17	Th17	NNP
cord-296585-yfh5d4io	614	12	cells	cell	NNS
cord-296585-yfh5d4io	614	13	provides	provide	VBZ
cord-296585-yfh5d4io	614	14	broad	broad	JJ
cord-296585-yfh5d4io	614	15	protection	protection	NN
cord-296585-yfh5d4io	614	16	against	against	IN
cord-296585-yfh5d4io	614	17	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	614	18	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	614	19	influenzae	influenzae	NN
cord-296585-yfh5d4io	614	20	infection	infection	NN
cord-296585-yfh5d4io	614	21	Immunoglobulin	Immunoglobulin	NNP
cord-296585-yfh5d4io	614	22	concentrations	concentration	NNS
cord-296585-yfh5d4io	614	23	in	in	IN
cord-296585-yfh5d4io	614	24	serum	serum	NN
cord-296585-yfh5d4io	614	25	and	and	CC
cord-296585-yfh5d4io	614	26	nasal	nasal	NN
cord-296585-yfh5d4io	614	27	secretions	secretion	NNS
cord-296585-yfh5d4io	614	28	in	in	IN
cord-296585-yfh5d4io	614	29	chronic	chronic	JJ
cord-296585-yfh5d4io	614	30	obstructive	obstructive	JJ
cord-296585-yfh5d4io	614	31	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	614	32	disease	disease	NN
cord-296585-yfh5d4io	614	33	.	.	.
cord-296585-yfh5d4io	615	1	A	a	DT
cord-296585-yfh5d4io	615	2	matched	match	VBN
cord-296585-yfh5d4io	615	3	-	-	HYPH
cord-296585-yfh5d4io	615	4	pair	pair	NN
cord-296585-yfh5d4io	615	5	study	study	NN
cord-296585-yfh5d4io	615	6	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	615	7	influenzae	influenzae	NN
cord-296585-yfh5d4io	615	8	infections	infection	NNS
cord-296585-yfh5d4io	615	9	in	in	IN
cord-296585-yfh5d4io	615	10	patients	patient	NNS
cord-296585-yfh5d4io	615	11	with	with	IN
cord-296585-yfh5d4io	615	12	chronic	chronic	JJ
cord-296585-yfh5d4io	615	13	obstructive	obstructive	JJ
cord-296585-yfh5d4io	615	14	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	615	15	disease	disease	NN
cord-296585-yfh5d4io	615	16	despite	despite	IN
cord-296585-yfh5d4io	615	17	specific	specific	JJ
cord-296585-yfh5d4io	615	18	antibodies	antibody	NNS
cord-296585-yfh5d4io	615	19	in	in	IN
cord-296585-yfh5d4io	615	20	serum	serum	NN
cord-296585-yfh5d4io	615	21	and	and	CC
cord-296585-yfh5d4io	615	22	sputum	sputum	NN
cord-296585-yfh5d4io	615	23	Mucosal	Mucosal	NNP
cord-296585-yfh5d4io	615	24	immunization	immunization	NN
cord-296585-yfh5d4io	615	25	:	:	:
cord-296585-yfh5d4io	615	26	a	a	DT
cord-296585-yfh5d4io	615	27	realistic	realistic	JJ
cord-296585-yfh5d4io	615	28	alternative	alternative	NN
cord-296585-yfh5d4io	615	29	Mapping	mapping	NN
cord-296585-yfh5d4io	615	30	of	of	IN
cord-296585-yfh5d4io	615	31	a	a	DT
cord-296585-yfh5d4io	615	32	strain	strain	NN
cord-296585-yfh5d4io	615	33	-	-	HYPH
cord-296585-yfh5d4io	615	34	specific	specific	JJ
cord-296585-yfh5d4io	615	35	bactericidal	bactericidal	JJ
cord-296585-yfh5d4io	615	36	epitope	epitope	NN
cord-296585-yfh5d4io	615	37	to	to	IN
cord-296585-yfh5d4io	615	38	the	the	DT
cord-296585-yfh5d4io	615	39	surface	surface	NN
cord-296585-yfh5d4io	615	40	-	-	HYPH
cord-296585-yfh5d4io	615	41	exposed	expose	VBN
cord-296585-yfh5d4io	615	42	loop	loop	NN
cord-296585-yfh5d4io	615	43	5	5	CD
cord-296585-yfh5d4io	615	44	on	on	IN
cord-296585-yfh5d4io	615	45	the	the	DT
cord-296585-yfh5d4io	615	46	P2	P2	NNP
cord-296585-yfh5d4io	615	47	porin	porin	NN
cord-296585-yfh5d4io	615	48	protein	protein	NN
cord-296585-yfh5d4io	615	49	of	of	IN
cord-296585-yfh5d4io	615	50	non	non	JJ
cord-296585-yfh5d4io	615	51	-	-	JJ
cord-296585-yfh5d4io	615	52	typeable	typeable	JJ
cord-296585-yfh5d4io	615	53	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	615	54	influenzae	influenzae	NN
cord-296585-yfh5d4io	615	55	Relationships	relationship	NNS
cord-296585-yfh5d4io	615	56	between	between	IN
cord-296585-yfh5d4io	615	57	mucosal	mucosal	JJ
cord-296585-yfh5d4io	615	58	antibodies	antibody	NNS
cord-296585-yfh5d4io	615	59	,	,	,
cord-296585-yfh5d4io	615	60	non	non	JJ
cord-296585-yfh5d4io	615	61	-	-	JJ
cord-296585-yfh5d4io	615	62	typeable	typeable	JJ
cord-296585-yfh5d4io	615	63	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	615	64	influenzae	influenzae	NN
cord-296585-yfh5d4io	615	65	(	(	-LRB-
cord-296585-yfh5d4io	615	66	NTHi	NTHi	NNS
cord-296585-yfh5d4io	615	67	)	)	-RRB-
cord-296585-yfh5d4io	615	68	infection	infection	NN
cord-296585-yfh5d4io	615	69	and	and	CC
cord-296585-yfh5d4io	615	70	airway	airway	NN
cord-296585-yfh5d4io	615	71	inflammation	inflammation	NN
cord-296585-yfh5d4io	615	72	in	in	IN
cord-296585-yfh5d4io	615	73	COPD	COPD	NNP
cord-296585-yfh5d4io	615	74	Bronchial	bronchial	JJ
cord-296585-yfh5d4io	615	75	secretory	secretory	JJ
cord-296585-yfh5d4io	615	76	immunoglobulin	immunoglobulin	NN
cord-296585-yfh5d4io	616	1	a	a	DT
cord-296585-yfh5d4io	616	2	deficiency	deficiency	NN
cord-296585-yfh5d4io	616	3	correlates	correlate	VBZ
cord-296585-yfh5d4io	616	4	with	with	IN
cord-296585-yfh5d4io	616	5	airway	airway	JJ
cord-296585-yfh5d4io	616	6	inflammation	inflammation	NN
cord-296585-yfh5d4io	616	7	and	and	CC
cord-296585-yfh5d4io	616	8	progression	progression	NN
cord-296585-yfh5d4io	616	9	of	of	IN
cord-296585-yfh5d4io	616	10	chronic	chronic	JJ
cord-296585-yfh5d4io	616	11	obstructive	obstructive	JJ
cord-296585-yfh5d4io	616	12	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	616	13	disease	disease	NN
cord-296585-yfh5d4io	616	14	Specific	Specific	NNP
cord-296585-yfh5d4io	616	15	IgA	iga	NN
cord-296585-yfh5d4io	616	16	and	and	CC
cord-296585-yfh5d4io	616	17	metalloproteinase	metalloproteinase	NN
cord-296585-yfh5d4io	616	18	activity	activity	NN
cord-296585-yfh5d4io	616	19	in	in	IN
cord-296585-yfh5d4io	616	20	bronchial	bronchial	JJ
cord-296585-yfh5d4io	616	21	secretions	secretion	NNS
cord-296585-yfh5d4io	616	22	from	from	IN
cord-296585-yfh5d4io	616	23	stable	stable	JJ
cord-296585-yfh5d4io	616	24	chronic	chronic	JJ
cord-296585-yfh5d4io	616	25	obstructive	obstructive	JJ
cord-296585-yfh5d4io	616	26	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	616	27	disease	disease	NN
cord-296585-yfh5d4io	616	28	patients	patient	NNS
cord-296585-yfh5d4io	616	29	colonized	colonize	VBN
cord-296585-yfh5d4io	616	30	by	by	IN
cord-296585-yfh5d4io	616	31	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	616	32	influenzae	influenzae	NN
cord-296585-yfh5d4io	616	33	Emphysematous	Emphysematous	NNP
cord-296585-yfh5d4io	616	34	lung	lung	NN
cord-296585-yfh5d4io	616	35	destruction	destruction	NN
cord-296585-yfh5d4io	616	36	by	by	IN
cord-296585-yfh5d4io	616	37	cigarette	cigarette	NN
cord-296585-yfh5d4io	616	38	smoke	smoke	NN
cord-296585-yfh5d4io	616	39	.	.	.
cord-296585-yfh5d4io	617	1	The	the	DT
cord-296585-yfh5d4io	617	2	effects	effect	NNS
cord-296585-yfh5d4io	617	3	of	of	IN
cord-296585-yfh5d4io	617	4	latent	latent	JJ
cord-296585-yfh5d4io	617	5	adenoviral	adenoviral	JJ
cord-296585-yfh5d4io	617	6	infection	infection	NN
cord-296585-yfh5d4io	617	7	on	on	IN
cord-296585-yfh5d4io	617	8	the	the	DT
cord-296585-yfh5d4io	617	9	lung	lung	NN
cord-296585-yfh5d4io	617	10	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	617	11	response	response	NN
cord-296585-yfh5d4io	617	12	Polymeric	Polymeric	NNP
cord-296585-yfh5d4io	617	13	immunoglobulin	immunoglobulin	NN
cord-296585-yfh5d4io	617	14	receptor	receptor	NN
cord-296585-yfh5d4io	617	15	down	down	IN
cord-296585-yfh5d4io	617	16	-	-	HYPH
cord-296585-yfh5d4io	617	17	regulation	regulation	NN
cord-296585-yfh5d4io	617	18	in	in	IN
cord-296585-yfh5d4io	617	19	chronic	chronic	JJ
cord-296585-yfh5d4io	617	20	obstructive	obstructive	JJ
cord-296585-yfh5d4io	617	21	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	617	22	disease	disease	NN
cord-296585-yfh5d4io	617	23	.	.	.
cord-296585-yfh5d4io	618	1	Persistence	persistence	NN
cord-296585-yfh5d4io	618	2	in	in	IN
cord-296585-yfh5d4io	618	3	the	the	DT
cord-296585-yfh5d4io	618	4	cultured	cultured	JJ
cord-296585-yfh5d4io	618	5	epithelium	epithelium	NN
cord-296585-yfh5d4io	618	6	and	and	CC
cord-296585-yfh5d4io	618	7	role	role	NN
cord-296585-yfh5d4io	618	8	of	of	IN
cord-296585-yfh5d4io	618	9	transforming	transform	VBG
cord-296585-yfh5d4io	618	10	growth	growth	NN
cord-296585-yfh5d4io	618	11	factor	factor	NN
cord-296585-yfh5d4io	619	1	-β	-β	.
cord-296585-yfh5d4io	620	1	Airway	airway	JJ
cord-296585-yfh5d4io	620	2	bacteria	bacteria	NNS
cord-296585-yfh5d4io	620	3	drive	drive	VBP
cord-296585-yfh5d4io	620	4	a	a	DT
cord-296585-yfh5d4io	620	5	progressive	progressive	JJ
cord-296585-yfh5d4io	620	6	COPD	COPD	NNP
cord-296585-yfh5d4io	620	7	-	-	HYPH
cord-296585-yfh5d4io	620	8	like	like	JJ
cord-296585-yfh5d4io	620	9	phenotype	phenotype	NN
cord-296585-yfh5d4io	620	10	in	in	IN
cord-296585-yfh5d4io	620	11	mice	mouse	NNS
cord-296585-yfh5d4io	620	12	with	with	IN
cord-296585-yfh5d4io	620	13	polymeric	polymeric	JJ
cord-296585-yfh5d4io	620	14	immunoglobulin	immunoglobulin	NN
cord-296585-yfh5d4io	620	15	receptor	receptor	NN
cord-296585-yfh5d4io	620	16	deficiency	deficiency	NN
cord-296585-yfh5d4io	620	17	Hypogammaglobulinaemia	Hypogammaglobulinaemia	NNP
cord-296585-yfh5d4io	620	18	:	:	:
cord-296585-yfh5d4io	620	19	cumulative	cumulative	JJ
cord-296585-yfh5d4io	620	20	experience	experience	NN
cord-296585-yfh5d4io	620	21	in	in	IN
cord-296585-yfh5d4io	620	22	49	49	CD
cord-296585-yfh5d4io	620	23	patients	patient	NNS
cord-296585-yfh5d4io	620	24	in	in	IN
cord-296585-yfh5d4io	620	25	a	a	DT
cord-296585-yfh5d4io	620	26	tertiary	tertiary	JJ
cord-296585-yfh5d4io	620	27	care	care	NN
cord-296585-yfh5d4io	620	28	institution	institution	NN
cord-296585-yfh5d4io	620	29	Evasion	evasion	NN
cord-296585-yfh5d4io	620	30	of	of	IN
cord-296585-yfh5d4io	620	31	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	620	32	extracellular	extracellular	JJ
cord-296585-yfh5d4io	620	33	traps	trap	NNS
cord-296585-yfh5d4io	620	34	by	by	IN
cord-296585-yfh5d4io	620	35	respiratory	respiratory	JJ
cord-296585-yfh5d4io	620	36	pathogens	pathogen	NNS
cord-296585-yfh5d4io	620	37	Impaired	impair	VBN
cord-296585-yfh5d4io	620	38	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	620	39	of	of	IN
cord-296585-yfh5d4io	620	40	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	620	41	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	620	42	influenzae	influenzae	NN
cord-296585-yfh5d4io	620	43	by	by	IN
cord-296585-yfh5d4io	620	44	human	human	JJ
cord-296585-yfh5d4io	620	45	alveolar	alveolar	NN
cord-296585-yfh5d4io	620	46	macrophages	macrophage	NNS
cord-296585-yfh5d4io	620	47	in	in	IN
cord-296585-yfh5d4io	620	48	chronic	chronic	JJ
cord-296585-yfh5d4io	620	49	obstructive	obstructive	JJ
cord-296585-yfh5d4io	620	50	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	620	51	disease	disease	NN
cord-296585-yfh5d4io	621	1	Impaired	impair	VBN
cord-296585-yfh5d4io	621	2	innate	innate	JJ
cord-296585-yfh5d4io	621	3	immune	immune	JJ
cord-296585-yfh5d4io	621	4	alveolar	alveolar	NN
cord-296585-yfh5d4io	621	5	macrophage	macrophage	NN
cord-296585-yfh5d4io	621	6	response	response	NN
cord-296585-yfh5d4io	621	7	and	and	CC
cord-296585-yfh5d4io	621	8	the	the	DT
cord-296585-yfh5d4io	621	9	predilection	predilection	NN
cord-296585-yfh5d4io	621	10	for	for	IN
cord-296585-yfh5d4io	621	11	COPD	COPD	NNP
cord-296585-yfh5d4io	621	12	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	622	1	Impaired	impaired	JJ
cord-296585-yfh5d4io	622	2	alveolar	alveolar	NN
cord-296585-yfh5d4io	622	3	macrophage	macrophage	NN
cord-296585-yfh5d4io	622	4	response	response	NN
cord-296585-yfh5d4io	622	5	to	to	IN
cord-296585-yfh5d4io	622	6	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	622	7	antigens	antigen	NNS
cord-296585-yfh5d4io	622	8	in	in	IN
cord-296585-yfh5d4io	622	9	chronic	chronic	JJ
cord-296585-yfh5d4io	622	10	obstructive	obstructive	JJ
cord-296585-yfh5d4io	622	11	lung	lung	NN
cord-296585-yfh5d4io	622	12	disease	disease	NN
cord-296585-yfh5d4io	623	1	The	the	DT
cord-296585-yfh5d4io	623	2	effects	effect	NNS
cord-296585-yfh5d4io	623	3	of	of	IN
cord-296585-yfh5d4io	623	4	repeated	repeat	VBN
cord-296585-yfh5d4io	623	5	Toll	toll	NN
cord-296585-yfh5d4io	623	6	-	-	HYPH
cord-296585-yfh5d4io	623	7	like	like	JJ
cord-296585-yfh5d4io	623	8	receptors	receptor	NNS
cord-296585-yfh5d4io	623	9	2	2	CD
cord-296585-yfh5d4io	623	10	and	and	CC
cord-296585-yfh5d4io	623	11	4	4	CD
cord-296585-yfh5d4io	623	12	stimulation	stimulation	NN
cord-296585-yfh5d4io	623	13	in	in	IN
cord-296585-yfh5d4io	623	14	COPD	COPD	NNP
cord-296585-yfh5d4io	623	15	alveolar	alveolar	NN
cord-296585-yfh5d4io	623	16	macrophages	macrophage	NNS
cord-296585-yfh5d4io	624	1	The	the	DT
cord-296585-yfh5d4io	624	2	T	t	NN
cord-296585-yfh5d4io	624	3	-	-	HYPH
cord-296585-yfh5d4io	624	4	helper	helper	NN
cord-296585-yfh5d4io	624	5	cell	cell	NN
cord-296585-yfh5d4io	624	6	type	type	NN
cord-296585-yfh5d4io	624	7	1	1	CD
cord-296585-yfh5d4io	624	8	immune	immune	JJ
cord-296585-yfh5d4io	624	9	response	response	NN
cord-296585-yfh5d4io	624	10	to	to	IN
cord-296585-yfh5d4io	624	11	gram	gram	JJ
cord-296585-yfh5d4io	624	12	-	-	HYPH
cord-296585-yfh5d4io	624	13	negative	negative	JJ
cord-296585-yfh5d4io	624	14	bacterial	bacterial	JJ
cord-296585-yfh5d4io	624	15	infections	infection	NNS
cord-296585-yfh5d4io	624	16	is	be	VBZ
cord-296585-yfh5d4io	624	17	impaired	impair	VBN
cord-296585-yfh5d4io	624	18	in	in	IN
cord-296585-yfh5d4io	624	19	COPD	COPD	NNP
cord-296585-yfh5d4io	624	20	Epithelial	epithelial	JJ
cord-296585-yfh5d4io	624	21	expression	expression	NN
cord-296585-yfh5d4io	624	22	of	of	IN
cord-296585-yfh5d4io	624	23	TLR4	TLR4	NNP
cord-296585-yfh5d4io	624	24	is	be	VBZ
cord-296585-yfh5d4io	624	25	modulated	modulate	VBN
cord-296585-yfh5d4io	624	26	in	in	IN
cord-296585-yfh5d4io	624	27	COPD	COPD	NNP
cord-296585-yfh5d4io	624	28	and	and	CC
cord-296585-yfh5d4io	624	29	by	by	IN
cord-296585-yfh5d4io	624	30	steroids	steroid	NNS
cord-296585-yfh5d4io	624	31	,	,	,
cord-296585-yfh5d4io	624	32	salmeterol	salmeterol	NN
cord-296585-yfh5d4io	624	33	and	and	CC
cord-296585-yfh5d4io	624	34	cigarette	cigarette	NN
cord-296585-yfh5d4io	624	35	smoke	smoke	NN
cord-296585-yfh5d4io	624	36	Toll	Toll	NNP
cord-296585-yfh5d4io	624	37	-	-	HYPH
cord-296585-yfh5d4io	624	38	like	like	JJ
cord-296585-yfh5d4io	624	39	receptor	receptor	NN
cord-296585-yfh5d4io	624	40	expression	expression	NN
cord-296585-yfh5d4io	624	41	in	in	IN
cord-296585-yfh5d4io	624	42	smokers	smoker	NNS
cord-296585-yfh5d4io	624	43	with	with	IN
cord-296585-yfh5d4io	624	44	and	and	CC
cord-296585-yfh5d4io	624	45	without	without	IN
cord-296585-yfh5d4io	624	46	COPD	COPD	NNP
cord-296585-yfh5d4io	624	47	Expression	Expression	NNP
cord-296585-yfh5d4io	624	48	of	of	IN
cord-296585-yfh5d4io	624	49	Toll	Toll	NNP
cord-296585-yfh5d4io	624	50	-	-	HYPH
cord-296585-yfh5d4io	624	51	like	like	JJ
cord-296585-yfh5d4io	624	52	receptor	receptor	NN
cord-296585-yfh5d4io	624	53	2	2	CD
cord-296585-yfh5d4io	624	54	and	and	CC
cord-296585-yfh5d4io	624	55	4	4	CD
cord-296585-yfh5d4io	624	56	in	in	IN
cord-296585-yfh5d4io	624	57	peripheral	peripheral	JJ
cord-296585-yfh5d4io	624	58	blood	blood	NN
cord-296585-yfh5d4io	624	59	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	624	60	cells	cell	NNS
cord-296585-yfh5d4io	624	61	from	from	IN
cord-296585-yfh5d4io	624	62	patients	patient	NNS
cord-296585-yfh5d4io	624	63	with	with	IN
cord-296585-yfh5d4io	624	64	chronic	chronic	JJ
cord-296585-yfh5d4io	624	65	obstructive	obstructive	JJ
cord-296585-yfh5d4io	624	66	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	624	67	disease	disease	NN
cord-296585-yfh5d4io	624	68	Lung	Lung	NNP
cord-296585-yfh5d4io	624	69	CD8	CD8	NNP
cord-296585-yfh5d4io	624	70	+	+	CC
cord-296585-yfh5d4io	624	71	T	T	NNP
cord-296585-yfh5d4io	624	72	cells	cell	NNS
cord-296585-yfh5d4io	624	73	in	in	IN
cord-296585-yfh5d4io	624	74	COPD	COPD	NNP
cord-296585-yfh5d4io	624	75	have	have	VBP
cord-296585-yfh5d4io	624	76	increased	increase	VBN
cord-296585-yfh5d4io	624	77	expression	expression	NN
cord-296585-yfh5d4io	624	78	of	of	IN
cord-296585-yfh5d4io	624	79	bacterial	bacterial	JJ
cord-296585-yfh5d4io	624	80	TLRs	tlr	NNS
cord-296585-yfh5d4io	624	81	Increased	increase	VBN
cord-296585-yfh5d4io	624	82	neutrophil	neutrophil	NN
cord-296585-yfh5d4io	624	83	expression	expression	NN
cord-296585-yfh5d4io	624	84	of	of	IN
cord-296585-yfh5d4io	624	85	pattern	pattern	NN
cord-296585-yfh5d4io	624	86	recognition	recognition	NN
cord-296585-yfh5d4io	624	87	receptors	receptor	NNS
cord-296585-yfh5d4io	624	88	during	during	IN
cord-296585-yfh5d4io	624	89	COPD	COPD	NNP
cord-296585-yfh5d4io	624	90	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	624	91	Toll	Toll	NNP
cord-296585-yfh5d4io	624	92	-	-	HYPH
cord-296585-yfh5d4io	624	93	like	like	JJ
cord-296585-yfh5d4io	624	94	receptor	receptor	NN
cord-296585-yfh5d4io	624	95	(	(	-LRB-
cord-296585-yfh5d4io	624	96	TLR2	TLR2	NNP
cord-296585-yfh5d4io	624	97	and	and	CC
cord-296585-yfh5d4io	624	98	TLR4	TLR4	NNP
cord-296585-yfh5d4io	624	99	)	)	-RRB-
cord-296585-yfh5d4io	624	100	polymorphisms	polymorphism	NNS
cord-296585-yfh5d4io	624	101	and	and	CC
cord-296585-yfh5d4io	624	102	chronic	chronic	JJ
cord-296585-yfh5d4io	624	103	obstructive	obstructive	JJ
cord-296585-yfh5d4io	624	104	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	624	105	disease	disease	NN
cord-296585-yfh5d4io	625	1	Impaired	impair	VBN
cord-296585-yfh5d4io	625	2	innate	innate	JJ
cord-296585-yfh5d4io	625	3	COPD	COPD	NNP
cord-296585-yfh5d4io	625	4	alveolar	alveolar	NN
cord-296585-yfh5d4io	625	5	macrophage	macrophage	NN
cord-296585-yfh5d4io	625	6	responses	response	NNS
cord-296585-yfh5d4io	625	7	and	and	CC
cord-296585-yfh5d4io	625	8	Tolllike	Tolllike	NNP
cord-296585-yfh5d4io	625	9	receptor-9	receptor-9	NNP
cord-296585-yfh5d4io	625	10	polymorphisms	polymorphism	VBZ
cord-296585-yfh5d4io	625	11	TLR9	TLR9	NNP
cord-296585-yfh5d4io	625	12	as	as	IN
cord-296585-yfh5d4io	625	13	a	a	DT
cord-296585-yfh5d4io	625	14	key	key	JJ
cord-296585-yfh5d4io	625	15	receptor	receptor	NN
cord-296585-yfh5d4io	625	16	for	for	IN
cord-296585-yfh5d4io	625	17	the	the	DT
cord-296585-yfh5d4io	625	18	recognition	recognition	NN
cord-296585-yfh5d4io	625	19	of	of	IN
cord-296585-yfh5d4io	625	20	DNA	DNA	NNP
cord-296585-yfh5d4io	625	21	Impact	Impact	NNP
cord-296585-yfh5d4io	625	22	of	of	IN
cord-296585-yfh5d4io	625	23	cigarette	cigarette	NN
cord-296585-yfh5d4io	625	24	smoke	smoke	NN
cord-296585-yfh5d4io	625	25	on	on	IN
cord-296585-yfh5d4io	625	26	clearance	clearance	NN
cord-296585-yfh5d4io	625	27	and	and	CC
cord-296585-yfh5d4io	625	28	inflammation	inflammation	NN
cord-296585-yfh5d4io	625	29	after	after	IN
cord-296585-yfh5d4io	625	30	Pseudomonas	Pseudomonas	NNP
cord-296585-yfh5d4io	625	31	aeruginosa	aeruginosa	VBZ
cord-296585-yfh5d4io	625	32	infection	infection	NN
cord-296585-yfh5d4io	625	33	Effects	effect	NNS
cord-296585-yfh5d4io	625	34	of	of	IN
cord-296585-yfh5d4io	625	35	cigarette	cigarette	NN
cord-296585-yfh5d4io	625	36	smoke	smoke	NN
cord-296585-yfh5d4io	625	37	on	on	IN
cord-296585-yfh5d4io	625	38	Toll	Toll	NNP
cord-296585-yfh5d4io	625	39	-	-	HYPH
cord-296585-yfh5d4io	625	40	like	like	JJ
cord-296585-yfh5d4io	625	41	receptor	receptor	NN
cord-296585-yfh5d4io	625	42	(	(	-LRB-
cord-296585-yfh5d4io	625	43	TLR	TLR	NNP
cord-296585-yfh5d4io	625	44	)	)	-RRB-
cord-296585-yfh5d4io	625	45	activation	activation	NN
cord-296585-yfh5d4io	625	46	of	of	IN
cord-296585-yfh5d4io	625	47	chronic	chronic	JJ
cord-296585-yfh5d4io	625	48	obstructive	obstructive	JJ
cord-296585-yfh5d4io	625	49	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	625	50	disease	disease	NN
cord-296585-yfh5d4io	625	51	(	(	-LRB-
cord-296585-yfh5d4io	625	52	COPD	COPD	NNP
cord-296585-yfh5d4io	625	53	)	)	-RRB-
cord-296585-yfh5d4io	626	1	macrophages	macrophage	NNS
cord-296585-yfh5d4io	627	1	The	the	DT
cord-296585-yfh5d4io	627	2	impact	impact	NN
cord-296585-yfh5d4io	627	3	of	of	IN
cord-296585-yfh5d4io	627	4	exogenous	exogenous	JJ
cord-296585-yfh5d4io	627	5	factors	factor	NNS
cord-296585-yfh5d4io	627	6	on	on	IN
cord-296585-yfh5d4io	627	7	respiratory	respiratory	JJ
cord-296585-yfh5d4io	627	8	pathogen	pathogen	NN
cord-296585-yfh5d4io	627	9	-	-	HYPH
cord-296585-yfh5d4io	627	10	induced	induce	VBN
cord-296585-yfh5d4io	627	11	innate	innate	JJ
cord-296585-yfh5d4io	627	12	alveolar	alveolar	JJ
cord-296585-yfh5d4io	627	13	macrophage	macrophage	NN
cord-296585-yfh5d4io	627	14	responses	response	NNS
cord-296585-yfh5d4io	627	15	in	in	IN
cord-296585-yfh5d4io	627	16	COPD	COPD	NNP
cord-296585-yfh5d4io	628	1	Targeting	target	VBG
cord-296585-yfh5d4io	628	2	Nrf2	Nrf2	NNP
cord-296585-yfh5d4io	628	3	signaling	signaling	NN
cord-296585-yfh5d4io	628	4	improves	improve	VBZ
cord-296585-yfh5d4io	628	5	bacterial	bacterial	JJ
cord-296585-yfh5d4io	628	6	clearance	clearance	NN
cord-296585-yfh5d4io	628	7	by	by	IN
cord-296585-yfh5d4io	628	8	alveolar	alveolar	JJ
cord-296585-yfh5d4io	628	9	macrophages	macrophage	NNS
cord-296585-yfh5d4io	628	10	in	in	IN
cord-296585-yfh5d4io	628	11	patients	patient	NNS
cord-296585-yfh5d4io	628	12	with	with	IN
cord-296585-yfh5d4io	628	13	COPD	COPD	NNP
cord-296585-yfh5d4io	628	14	and	and	CC
cord-296585-yfh5d4io	628	15	in	in	IN
cord-296585-yfh5d4io	628	16	a	a	DT
cord-296585-yfh5d4io	628	17	mouse	mouse	NN
cord-296585-yfh5d4io	628	18	model	model	NN
cord-296585-yfh5d4io	628	19	Antagonism	antagonism	NN
cord-296585-yfh5d4io	628	20	of	of	IN
cord-296585-yfh5d4io	628	21	miR-328	miR-328	NNP
cord-296585-yfh5d4io	628	22	increases	increase	VBZ
cord-296585-yfh5d4io	628	23	the	the	DT
cord-296585-yfh5d4io	628	24	antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	628	25	function	function	NN
cord-296585-yfh5d4io	628	26	of	of	IN
cord-296585-yfh5d4io	628	27	macrophages	macrophage	NNS
cord-296585-yfh5d4io	628	28	and	and	CC
cord-296585-yfh5d4io	628	29	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	628	30	and	and	CC
cord-296585-yfh5d4io	628	31	rapid	rapid	JJ
cord-296585-yfh5d4io	628	32	clearance	clearance	NN
cord-296585-yfh5d4io	628	33	of	of	IN
cord-296585-yfh5d4io	628	34	non	non	JJ
cord-296585-yfh5d4io	628	35	-	-	JJ
cord-296585-yfh5d4io	628	36	typeable	typeable	JJ
cord-296585-yfh5d4io	628	37	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	628	38	influenzae	influenzae	NN
cord-296585-yfh5d4io	628	39	(	(	-LRB-
cord-296585-yfh5d4io	628	40	NTHi	NTHi	NNS
cord-296585-yfh5d4io	628	41	)	)	-RRB-
cord-296585-yfh5d4io	628	42	from	from	IN
cord-296585-yfh5d4io	628	43	infected	infected	JJ
cord-296585-yfh5d4io	628	44	lung	lung	NN
cord-296585-yfh5d4io	628	45	Bacteria	Bacteria	NNS
cord-296585-yfh5d4io	628	46	challenge	challenge	VBP
cord-296585-yfh5d4io	628	47	in	in	IN
cord-296585-yfh5d4io	628	48	smoke	smoke	NN
cord-296585-yfh5d4io	628	49	-	-	HYPH
cord-296585-yfh5d4io	628	50	exposed	expose	VBN
cord-296585-yfh5d4io	628	51	mice	mouse	NNS
cord-296585-yfh5d4io	629	1	exacerbates	exacerbate	VBZ
cord-296585-yfh5d4io	629	2	inflammation	inflammation	NN
cord-296585-yfh5d4io	629	3	and	and	CC
cord-296585-yfh5d4io	629	4	skews	skew	VBZ
cord-296585-yfh5d4io	629	5	the	the	DT
cord-296585-yfh5d4io	629	6	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	629	7	profile	profile	NN
cord-296585-yfh5d4io	629	8	Mechanisms	mechanism	NNS
cord-296585-yfh5d4io	629	9	of	of	IN
cord-296585-yfh5d4io	629	10	clearance	clearance	NN
cord-296585-yfh5d4io	629	11	of	of	IN
cord-296585-yfh5d4io	629	12	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	629	13	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	629	14	influenzae	influenzae	NN
cord-296585-yfh5d4io	629	15	from	from	IN
cord-296585-yfh5d4io	629	16	cigarette	cigarette	NN
cord-296585-yfh5d4io	629	17	smoke	smoke	NN
cord-296585-yfh5d4io	629	18	-	-	HYPH
cord-296585-yfh5d4io	629	19	exposed	expose	VBN
cord-296585-yfh5d4io	629	20	mouse	mouse	NN
cord-296585-yfh5d4io	629	21	lungs	lung	VBZ
cord-296585-yfh5d4io	629	22	Cigarette	cigarette	NN
cord-296585-yfh5d4io	629	23	smoke	smoke	NN
cord-296585-yfh5d4io	629	24	exposure	exposure	NN
cord-296585-yfh5d4io	629	25	exacerbates	exacerbate	VBZ
cord-296585-yfh5d4io	629	26	lung	lung	NN
cord-296585-yfh5d4io	629	27	inflammation	inflammation	NN
cord-296585-yfh5d4io	629	28	and	and	CC
cord-296585-yfh5d4io	629	29	compromises	compromise	VBZ
cord-296585-yfh5d4io	629	30	immunity	immunity	NN
cord-296585-yfh5d4io	629	31	to	to	IN
cord-296585-yfh5d4io	629	32	bacterial	bacterial	JJ
cord-296585-yfh5d4io	629	33	infection	infection	NN
cord-296585-yfh5d4io	630	1	Secondhand	secondhand	JJ
cord-296585-yfh5d4io	630	2	smoke	smoke	NN
cord-296585-yfh5d4io	630	3	induces	induce	VBZ
cord-296585-yfh5d4io	630	4	inflammation	inflammation	NN
cord-296585-yfh5d4io	630	5	and	and	CC
cord-296585-yfh5d4io	630	6	impairs	impair	VBZ
cord-296585-yfh5d4io	630	7	immunity	immunity	NN
cord-296585-yfh5d4io	630	8	to	to	IN
cord-296585-yfh5d4io	630	9	respiratory	respiratory	JJ
cord-296585-yfh5d4io	630	10	infections	infection	NNS
cord-296585-yfh5d4io	630	11	Interleukin-22	interleukin-22	NN
cord-296585-yfh5d4io	630	12	protects	protect	VBZ
cord-296585-yfh5d4io	630	13	against	against	IN
cord-296585-yfh5d4io	630	14	non	non	JJ
cord-296585-yfh5d4io	630	15	-	-	JJ
cord-296585-yfh5d4io	630	16	typeable	typeable	JJ
cord-296585-yfh5d4io	630	17	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	630	18	influenzae	influenzae	NN
cord-296585-yfh5d4io	630	19	infection	infection	NN
cord-296585-yfh5d4io	630	20	:	:	:
cord-296585-yfh5d4io	630	21	alteration	alteration	NN
cord-296585-yfh5d4io	630	22	during	during	IN
cord-296585-yfh5d4io	630	23	chronic	chronic	JJ
cord-296585-yfh5d4io	630	24	obstructive	obstructive	JJ
cord-296585-yfh5d4io	630	25	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	630	26	disease	disease	NN
cord-296585-yfh5d4io	630	27	IL-17A	IL-17A	NNP
cord-296585-yfh5d4io	630	28	and	and	CC
cord-296585-yfh5d4io	630	29	the	the	DT
cord-296585-yfh5d4io	630	30	promotion	promotion	NN
cord-296585-yfh5d4io	630	31	of	of	IN
cord-296585-yfh5d4io	630	32	neutrophilia	neutrophilia	NNP
cord-296585-yfh5d4io	630	33	in	in	IN
cord-296585-yfh5d4io	630	34	acute	acute	JJ
cord-296585-yfh5d4io	630	35	exacerbation	exacerbation	NN
cord-296585-yfh5d4io	630	36	of	of	IN
cord-296585-yfh5d4io	630	37	chronic	chronic	JJ
cord-296585-yfh5d4io	630	38	obstructive	obstructive	JJ
cord-296585-yfh5d4io	630	39	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	630	40	disease	disease	NN
cord-296585-yfh5d4io	630	41	Chronic	Chronic	NNP
cord-296585-yfh5d4io	630	42	obstructive	obstructive	JJ
cord-296585-yfh5d4io	630	43	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	630	44	disease	disease	NN
cord-296585-yfh5d4io	630	45	,	,	,
cord-296585-yfh5d4io	630	46	neutrophils	neutrophil	NNS
cord-296585-yfh5d4io	630	47	and	and	CC
cord-296585-yfh5d4io	630	48	bacterial	bacterial	JJ
cord-296585-yfh5d4io	630	49	infection	infection	NN
cord-296585-yfh5d4io	630	50	:	:	:
cord-296585-yfh5d4io	630	51	a	a	DT
cord-296585-yfh5d4io	630	52	complex	complex	JJ
cord-296585-yfh5d4io	630	53	web	web	NN
cord-296585-yfh5d4io	630	54	involving	involve	VBG
cord-296585-yfh5d4io	630	55	IL-17	IL-17	NNP
cord-296585-yfh5d4io	630	56	and	and	CC
cord-296585-yfh5d4io	630	57	IL-22	IL-22	NNP
cord-296585-yfh5d4io	630	58	unravels	unravel	VBZ
cord-296585-yfh5d4io	631	1	Antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	631	2	peptide	peptide	NN
cord-296585-yfh5d4io	631	3	levels	level	NNS
cord-296585-yfh5d4io	631	4	are	be	VBP
cord-296585-yfh5d4io	631	5	linked	link	VBN
cord-296585-yfh5d4io	631	6	to	to	IN
cord-296585-yfh5d4io	631	7	airway	airway	NN
cord-296585-yfh5d4io	631	8	inflammation	inflammation	NN
cord-296585-yfh5d4io	631	9	,	,	,
cord-296585-yfh5d4io	631	10	bacterial	bacterial	JJ
cord-296585-yfh5d4io	631	11	colonisation	colonisation	NN
cord-296585-yfh5d4io	631	12	and	and	CC
cord-296585-yfh5d4io	631	13	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	631	14	in	in	IN
cord-296585-yfh5d4io	631	15	chronic	chronic	JJ
cord-296585-yfh5d4io	631	16	obstructive	obstructive	JJ
cord-296585-yfh5d4io	631	17	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	631	18	disease	disease	NN
cord-296585-yfh5d4io	631	19	Antimicrobial	Antimicrobial	NNP
cord-296585-yfh5d4io	631	20	peptides	peptide	NNS
cord-296585-yfh5d4io	631	21	and	and	CC
cord-296585-yfh5d4io	631	22	innate	innate	JJ
cord-296585-yfh5d4io	631	23	lung	lung	NN
cord-296585-yfh5d4io	631	24	defenses	defense	NNS
cord-296585-yfh5d4io	631	25	:	:	:
cord-296585-yfh5d4io	631	26	role	role	NN
cord-296585-yfh5d4io	631	27	in	in	IN
cord-296585-yfh5d4io	631	28	infectious	infectious	JJ
cord-296585-yfh5d4io	631	29	and	and	CC
cord-296585-yfh5d4io	631	30	noninfectious	noninfectious	JJ
cord-296585-yfh5d4io	631	31	lung	lung	NN
cord-296585-yfh5d4io	631	32	diseases	disease	NNS
cord-296585-yfh5d4io	631	33	and	and	CC
cord-296585-yfh5d4io	631	34	therapeutic	therapeutic	JJ
cord-296585-yfh5d4io	631	35	applications	application	NNS
cord-296585-yfh5d4io	631	36	Secretory	secretory	JJ
cord-296585-yfh5d4io	631	37	leukocyte	leukocyte	NN
cord-296585-yfh5d4io	631	38	protease	protease	NN
cord-296585-yfh5d4io	631	39	inhibitor	inhibitor	NN
cord-296585-yfh5d4io	631	40	and	and	CC
cord-296585-yfh5d4io	631	41	elafin	elafin	NNP
cord-296585-yfh5d4io	631	42	/	/	SYM
cord-296585-yfh5d4io	631	43	trappin-2	trappin-2	RB
cord-296585-yfh5d4io	631	44	:	:	:
cord-296585-yfh5d4io	631	45	versatile	versatile	JJ
cord-296585-yfh5d4io	631	46	mucosal	mucosal	JJ
cord-296585-yfh5d4io	631	47	antimicrobials	antimicrobial	NNS
cord-296585-yfh5d4io	631	48	and	and	CC
cord-296585-yfh5d4io	631	49	regulators	regulator	NNS
cord-296585-yfh5d4io	631	50	of	of	IN
cord-296585-yfh5d4io	631	51	immunity	immunity	NN
cord-296585-yfh5d4io	631	52	Regulation	regulation	NN
cord-296585-yfh5d4io	631	53	and	and	CC
cord-296585-yfh5d4io	631	54	function	function	NN
cord-296585-yfh5d4io	631	55	of	of	IN
cord-296585-yfh5d4io	631	56	antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	631	57	peptides	peptide	NNS
cord-296585-yfh5d4io	631	58	in	in	IN
cord-296585-yfh5d4io	631	59	immunity	immunity	NN
cord-296585-yfh5d4io	631	60	and	and	CC
cord-296585-yfh5d4io	631	61	diseases	disease	NNS
cord-296585-yfh5d4io	631	62	of	of	IN
cord-296585-yfh5d4io	631	63	the	the	DT
cord-296585-yfh5d4io	631	64	lung	lung	NN
cord-296585-yfh5d4io	631	65	Host	Host	NNP
cord-296585-yfh5d4io	631	66	-	-	HYPH
cord-296585-yfh5d4io	631	67	microorganism	microorganism	NN
cord-296585-yfh5d4io	631	68	interactions	interaction	NNS
cord-296585-yfh5d4io	631	69	in	in	IN
cord-296585-yfh5d4io	631	70	lung	lung	NN
cord-296585-yfh5d4io	631	71	diseases	disease	NNS
cord-296585-yfh5d4io	632	1	pH	pH	NNP
cord-296585-yfh5d4io	632	2	modulates	modulate	VBZ
cord-296585-yfh5d4io	632	3	the	the	DT
cord-296585-yfh5d4io	632	4	activity	activity	NN
cord-296585-yfh5d4io	632	5	and	and	CC
cord-296585-yfh5d4io	632	6	synergism	synergism	NN
cord-296585-yfh5d4io	632	7	of	of	IN
cord-296585-yfh5d4io	632	8	the	the	DT
cord-296585-yfh5d4io	632	9	airway	airway	NN
cord-296585-yfh5d4io	632	10	surface	surface	NN
cord-296585-yfh5d4io	632	11	liquid	liquid	JJ
cord-296585-yfh5d4io	632	12	antimicrobials	antimicrobial	NNS
cord-296585-yfh5d4io	632	13	beta	beta	NN
cord-296585-yfh5d4io	632	14	-	-	HYPH
cord-296585-yfh5d4io	632	15	defensin-3	defensin-3	NNP
cord-296585-yfh5d4io	632	16	and	and	CC
cord-296585-yfh5d4io	632	17	LL-37	LL-37	NNP
cord-296585-yfh5d4io	632	18	Peptidylarginine	Peptidylarginine	NNP
cord-296585-yfh5d4io	632	19	deiminases	deiminase	NNS
cord-296585-yfh5d4io	632	20	present	present	JJ
cord-296585-yfh5d4io	632	21	in	in	IN
cord-296585-yfh5d4io	632	22	the	the	DT
cord-296585-yfh5d4io	632	23	airways	airways	NNPS
cord-296585-yfh5d4io	632	24	during	during	IN
cord-296585-yfh5d4io	632	25	tobacco	tobacco	NN
cord-296585-yfh5d4io	632	26	smoking	smoking	NN
cord-296585-yfh5d4io	632	27	and	and	CC
cord-296585-yfh5d4io	632	28	inflammation	inflammation	NN
cord-296585-yfh5d4io	633	1	can	can	MD
cord-296585-yfh5d4io	633	2	citrullinate	citrullinate	VB
cord-296585-yfh5d4io	633	3	the	the	DT
cord-296585-yfh5d4io	633	4	host	host	NN
cord-296585-yfh5d4io	633	5	defense	defense	NN
cord-296585-yfh5d4io	633	6	peptide	peptide	NN
cord-296585-yfh5d4io	633	7	LL-37	LL-37	NNP
cord-296585-yfh5d4io	633	8	,	,	,
cord-296585-yfh5d4io	633	9	resulting	result	VBG
cord-296585-yfh5d4io	633	10	in	in	IN
cord-296585-yfh5d4io	633	11	altered	altered	JJ
cord-296585-yfh5d4io	633	12	activities	activity	NNS
cord-296585-yfh5d4io	633	13	Antibiotics	antibiotic	NNS
cord-296585-yfh5d4io	633	14	for	for	IN
cord-296585-yfh5d4io	633	15	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	633	16	of	of	IN
cord-296585-yfh5d4io	633	17	chronic	chronic	JJ
cord-296585-yfh5d4io	633	18	obstructive	obstructive	JJ
cord-296585-yfh5d4io	633	19	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	633	20	disease	disease	NN
cord-296585-yfh5d4io	633	21	Doxycycline	Doxycycline	NNP
cord-296585-yfh5d4io	633	22	for	for	IN
cord-296585-yfh5d4io	633	23	outpatient	outpatient	NN
cord-296585-yfh5d4io	633	24	-	-	HYPH
cord-296585-yfh5d4io	633	25	treated	treat	VBN
cord-296585-yfh5d4io	633	26	acute	acute	JJ
cord-296585-yfh5d4io	633	27	exacerbations	exacerbation	NNS
cord-296585-yfh5d4io	633	28	of	of	IN
cord-296585-yfh5d4io	633	29	COPD	COPD	NNP
cord-296585-yfh5d4io	633	30	:	:	:
cord-296585-yfh5d4io	634	1	a	a	DT
cord-296585-yfh5d4io	634	2	randomised	randomised	JJ
cord-296585-yfh5d4io	634	3	double	double	JJ
cord-296585-yfh5d4io	634	4	-	-	HYPH
cord-296585-yfh5d4io	634	5	blind	blind	JJ
cord-296585-yfh5d4io	634	6	placebo	placebo	NN
cord-296585-yfh5d4io	634	7	-	-	HYPH
cord-296585-yfh5d4io	634	8	controlled	control	VBN
cord-296585-yfh5d4io	634	9	trial	trial	NN
cord-296585-yfh5d4io	634	10	Performance	Performance	NNP
cord-296585-yfh5d4io	634	11	Standards	Standards	NNPS
cord-296585-yfh5d4io	634	12	for	for	IN
cord-296585-yfh5d4io	634	13	Antimicrobial	Antimicrobial	NNP
cord-296585-yfh5d4io	634	14	Susceptibility	Susceptibility	NNP
cord-296585-yfh5d4io	634	15	Testing	Testing	NNP
cord-296585-yfh5d4io	634	16	Breakpoint	Breakpoint	NNP
cord-296585-yfh5d4io	634	17	Tables	Tables	NNPS
cord-296585-yfh5d4io	634	18	for	for	IN
cord-296585-yfh5d4io	634	19	Interpretation	Interpretation	NNP
cord-296585-yfh5d4io	634	20	of	of	IN
cord-296585-yfh5d4io	634	21	MICs	mic	NNS
cord-296585-yfh5d4io	634	22	and	and	CC
cord-296585-yfh5d4io	634	23	Zone	Zone	NNP
cord-296585-yfh5d4io	634	24	Diameters	Diameters	NNPS
cord-296585-yfh5d4io	634	25	.	.	.
cord-296585-yfh5d4io	635	1	Version	version	NN
cord-296585-yfh5d4io	635	2	Effect	effect	NN
cord-296585-yfh5d4io	635	3	of	of	IN
cord-296585-yfh5d4io	635	4	fluoroquinolones	fluoroquinolone	NNS
cord-296585-yfh5d4io	635	5	and	and	CC
cord-296585-yfh5d4io	635	6	macrolides	macrolide	NNS
cord-296585-yfh5d4io	635	7	on	on	IN
cord-296585-yfh5d4io	635	8	eradication	eradication	NN
cord-296585-yfh5d4io	635	9	and	and	CC
cord-296585-yfh5d4io	635	10	resistance	resistance	NN
cord-296585-yfh5d4io	635	11	of	of	IN
cord-296585-yfh5d4io	635	12	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	635	13	influenzae	influenzae	NN
cord-296585-yfh5d4io	635	14	in	in	IN
cord-296585-yfh5d4io	635	15	chronic	chronic	JJ
cord-296585-yfh5d4io	635	16	obstructive	obstructive	JJ
cord-296585-yfh5d4io	635	17	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	635	18	disease	disease	NN
cord-296585-yfh5d4io	635	19	Multilocus	Multilocus	NNP
cord-296585-yfh5d4io	635	20	sequence	sequence	NN
cord-296585-yfh5d4io	635	21	typing	typing	NN
cord-296585-yfh5d4io	635	22	and	and	CC
cord-296585-yfh5d4io	635	23	ftsl	ftsl	NN
cord-296585-yfh5d4io	635	24	sequencing	sequencing	NN
cord-296585-yfh5d4io	635	25	:	:	:
cord-296585-yfh5d4io	635	26	a	a	DT
cord-296585-yfh5d4io	635	27	powerful	powerful	JJ
cord-296585-yfh5d4io	635	28	tool	tool	NN
cord-296585-yfh5d4io	635	29	for	for	IN
cord-296585-yfh5d4io	635	30	surveillance	surveillance	NN
cord-296585-yfh5d4io	635	31	of	of	IN
cord-296585-yfh5d4io	635	32	penicillin	penicillin	NN
cord-296585-yfh5d4io	635	33	-	-	HYPH
cord-296585-yfh5d4io	635	34	binding	bind	VBG
cord-296585-yfh5d4io	635	35	protein	protein	NN
cord-296585-yfh5d4io	635	36	3-mediated	3-mediated	CD
cord-296585-yfh5d4io	635	37	beta	beta	NN
cord-296585-yfh5d4io	635	38	-	-	HYPH
cord-296585-yfh5d4io	635	39	lactam	lactam	NN
cord-296585-yfh5d4io	635	40	resistance	resistance	NN
cord-296585-yfh5d4io	635	41	in	in	IN
cord-296585-yfh5d4io	635	42	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	635	43	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	635	44	influenzae	influenzae	NN
cord-296585-yfh5d4io	636	1	Antimicrobial	antimicrobial	JJ
cord-296585-yfh5d4io	636	2	resistance	resistance	NN
cord-296585-yfh5d4io	636	3	in	in	IN
cord-296585-yfh5d4io	636	4	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	636	5	influenzae	influenzae	NN
cord-296585-yfh5d4io	636	6	Increase	increase	NN
cord-296585-yfh5d4io	636	7	of	of	IN
cord-296585-yfh5d4io	636	8	β	β	NN
cord-296585-yfh5d4io	636	9	-	-	HYPH
cord-296585-yfh5d4io	636	10	lactam	lactam	NN
cord-296585-yfh5d4io	636	11	-	-	HYPH
cord-296585-yfh5d4io	636	12	resistant	resistant	JJ
cord-296585-yfh5d4io	636	13	invasive	invasive	JJ
cord-296585-yfh5d4io	636	14	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	636	15	influenzae	influenzae	NN
cord-296585-yfh5d4io	636	16	in	in	IN
cord-296585-yfh5d4io	636	17	Emergence	Emergence	NNP
cord-296585-yfh5d4io	636	18	of	of	IN
cord-296585-yfh5d4io	636	19	clonally	clonally	RB
cord-296585-yfh5d4io	636	20	related	related	JJ
cord-296585-yfh5d4io	636	21	multidrug	multidrug	NN
cord-296585-yfh5d4io	636	22	resistant	resistant	JJ
cord-296585-yfh5d4io	636	23	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	636	24	influenzae	influenzae	NN
cord-296585-yfh5d4io	636	25	with	with	IN
cord-296585-yfh5d4io	636	26	penicillin	penicillin	NN
cord-296585-yfh5d4io	636	27	-	-	HYPH
cord-296585-yfh5d4io	636	28	binding	bind	VBG
cord-296585-yfh5d4io	636	29	protein	protein	NN
cord-296585-yfh5d4io	636	30	3-mediated	3-mediated	CD
cord-296585-yfh5d4io	636	31	resistance	resistance	NN
cord-296585-yfh5d4io	636	32	to	to	IN
cord-296585-yfh5d4io	636	33	extended	extend	VBN
cord-296585-yfh5d4io	636	34	-	-	HYPH
cord-296585-yfh5d4io	636	35	spectrum	spectrum	NN
cord-296585-yfh5d4io	636	36	cephalosporins	cephalosporin	NNS
cord-296585-yfh5d4io	636	37	Ampicillin	Ampicillin	NNP
cord-296585-yfh5d4io	636	38	-	-	HYPH
cord-296585-yfh5d4io	636	39	resistant	resistant	JJ
cord-296585-yfh5d4io	636	40	non	non	JJ
cord-296585-yfh5d4io	636	41	-	-	JJ
cord-296585-yfh5d4io	636	42	beta	beta	JJ
cord-296585-yfh5d4io	636	43	-	-	HYPH
cord-296585-yfh5d4io	636	44	lactamaseproducing	lactamaseproduce	VBG
cord-296585-yfh5d4io	636	45	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	636	46	influenzae	influenzae	NN
cord-296585-yfh5d4io	636	47	in	in	IN
cord-296585-yfh5d4io	636	48	Spain	Spain	NNP
cord-296585-yfh5d4io	636	49	:	:	:
cord-296585-yfh5d4io	637	1	recent	recent	JJ
cord-296585-yfh5d4io	637	2	emergence	emergence	NN
cord-296585-yfh5d4io	637	3	of	of	IN
cord-296585-yfh5d4io	637	4	clonal	clonal	JJ
cord-296585-yfh5d4io	637	5	isolates	isolate	NNS
cord-296585-yfh5d4io	637	6	with	with	IN
cord-296585-yfh5d4io	637	7	increased	increase	VBN
cord-296585-yfh5d4io	637	8	resistance	resistance	NN
cord-296585-yfh5d4io	637	9	to	to	IN
cord-296585-yfh5d4io	637	10	cefotaxime	cefotaxime	NN
cord-296585-yfh5d4io	637	11	and	and	CC
cord-296585-yfh5d4io	637	12	cefixime	cefixime	NNP
cord-296585-yfh5d4io	638	1	An	an	DT
cord-296585-yfh5d4io	638	2	amino	amino	NN
cord-296585-yfh5d4io	638	3	acid	acid	NN
cord-296585-yfh5d4io	638	4	substitution	substitution	NN
cord-296585-yfh5d4io	638	5	in	in	IN
cord-296585-yfh5d4io	638	6	PBP-3	PBP-3	NNP
cord-296585-yfh5d4io	638	7	in	in	IN
cord-296585-yfh5d4io	638	8	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	638	9	influenzae	influenzae	NN
cord-296585-yfh5d4io	638	10	associate	associate	VB
cord-296585-yfh5d4io	638	11	with	with	IN
cord-296585-yfh5d4io	638	12	the	the	DT
cord-296585-yfh5d4io	638	13	invasion	invasion	NN
cord-296585-yfh5d4io	638	14	to	to	IN
cord-296585-yfh5d4io	638	15	bronchial	bronchial	JJ
cord-296585-yfh5d4io	638	16	epithelial	epithelial	JJ
cord-296585-yfh5d4io	638	17	cells	cell	NNS
cord-296585-yfh5d4io	639	1	Genotypically	genotypically	RB
cord-296585-yfh5d4io	639	2	defined	define	VBN
cord-296585-yfh5d4io	639	3	beta	beta	NN
cord-296585-yfh5d4io	639	4	-	-	HYPH
cord-296585-yfh5d4io	639	5	lactamase	lactamase	NN
cord-296585-yfh5d4io	639	6	-	-	HYPH
cord-296585-yfh5d4io	639	7	negative	negative	JJ
cord-296585-yfh5d4io	639	8	ampicillin	ampicillin	NN
cord-296585-yfh5d4io	639	9	-	-	HYPH
cord-296585-yfh5d4io	639	10	resistant	resistant	JJ
cord-296585-yfh5d4io	639	11	isolates	isolate	NNS
cord-296585-yfh5d4io	639	12	of	of	IN
cord-296585-yfh5d4io	639	13	non	non	JJ
cord-296585-yfh5d4io	639	14	-	-	JJ
cord-296585-yfh5d4io	639	15	typable	typable	JJ
cord-296585-yfh5d4io	639	16	Haemophilus	haemophilus	NN
cord-296585-yfh5d4io	639	17	influenzae	influenzae	NN
cord-296585-yfh5d4io	640	1	are	be	VBP
cord-296585-yfh5d4io	640	2	associated	associate	VBN
cord-296585-yfh5d4io	640	3	with	with	IN
cord-296585-yfh5d4io	640	4	increased	increase	VBN
cord-296585-yfh5d4io	640	5	invasion	invasion	NN
cord-296585-yfh5d4io	640	6	of	of	IN
cord-296585-yfh5d4io	640	7	bronchial	bronchial	JJ
cord-296585-yfh5d4io	640	8	epithelial	epithelial	JJ
cord-296585-yfh5d4io	640	9	cells	cell	NNS
cord-296585-yfh5d4io	640	10	in	in	IN
cord-296585-yfh5d4io	640	11	vitro	vitro	FW
cord-296585-yfh5d4io	640	12	Prophylactic	prophylactic	JJ
cord-296585-yfh5d4io	640	13	antibiotic	antibiotic	JJ
cord-296585-yfh5d4io	640	14	therapy	therapy	NN
cord-296585-yfh5d4io	640	15	for	for	IN
cord-296585-yfh5d4io	640	16	chronic	chronic	JJ
cord-296585-yfh5d4io	640	17	obstructive	obstructive	JJ
cord-296585-yfh5d4io	640	18	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	640	19	disease	disease	NN
cord-296585-yfh5d4io	640	20	(	(	-LRB-
cord-296585-yfh5d4io	640	21	COPD	COPD	NNP
cord-296585-yfh5d4io	640	22	)	)	-RRB-
cord-296585-yfh5d4io	640	23	Clinical	clinical	JJ
cord-296585-yfh5d4io	640	24	and	and	CC
cord-296585-yfh5d4io	640	25	safety	safety	NN
cord-296585-yfh5d4io	640	26	outcomes	outcome	NNS
cord-296585-yfh5d4io	640	27	of	of	IN
cord-296585-yfh5d4io	640	28	long	long	JJ
cord-296585-yfh5d4io	640	29	-	-	HYPH
cord-296585-yfh5d4io	640	30	term	term	NN
cord-296585-yfh5d4io	640	31	azithromycin	azithromycin	NN
cord-296585-yfh5d4io	640	32	therapy	therapy	NN
cord-296585-yfh5d4io	640	33	in	in	IN
cord-296585-yfh5d4io	640	34	severe	severe	JJ
cord-296585-yfh5d4io	640	35	COPD	COPD	NNP
cord-296585-yfh5d4io	640	36	beyond	beyond	IN
cord-296585-yfh5d4io	640	37	the	the	DT
cord-296585-yfh5d4io	640	38	first	first	JJ
cord-296585-yfh5d4io	640	39	year	year	NN
cord-296585-yfh5d4io	640	40	of	of	IN
cord-296585-yfh5d4io	640	41	treatment	treatment	NN
cord-296585-yfh5d4io	640	42	Azithromycin	Azithromycin	NNP
cord-296585-yfh5d4io	640	43	inhibits	inhibit	VBZ
cord-296585-yfh5d4io	640	44	mucus	mucus	NN
cord-296585-yfh5d4io	640	45	hypersecretion	hypersecretion	NN
cord-296585-yfh5d4io	640	46	from	from	IN
cord-296585-yfh5d4io	640	47	airway	airway	JJ
cord-296585-yfh5d4io	640	48	epithelial	epithelial	JJ
cord-296585-yfh5d4io	640	49	cells	cell	NNS
cord-296585-yfh5d4io	641	1	Azithromycin	Azithromycin	NNP
cord-296585-yfh5d4io	641	2	inhibits	inhibit	VBZ
cord-296585-yfh5d4io	641	3	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	641	4	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	641	5	influenzae	influenzae	NN
cord-296585-yfh5d4io	641	6	-	-	HYPH
cord-296585-yfh5d4io	641	7	induced	induce	VBN
cord-296585-yfh5d4io	641	8	MUC5AC	MUC5AC	NNP
cord-296585-yfh5d4io	641	9	expression	expression	NN
cord-296585-yfh5d4io	641	10	and	and	CC
cord-296585-yfh5d4io	641	11	secretion	secretion	NN
cord-296585-yfh5d4io	641	12	via	via	IN
cord-296585-yfh5d4io	641	13	inhibition	inhibition	NN
cord-296585-yfh5d4io	641	14	of	of	IN
cord-296585-yfh5d4io	641	15	activator	activator	NN
cord-296585-yfh5d4io	641	16	protein-1	protein-1	NNP
cord-296585-yfh5d4io	641	17	in	in	IN
cord-296585-yfh5d4io	641	18	human	human	JJ
cord-296585-yfh5d4io	641	19	airway	airway	NN
cord-296585-yfh5d4io	641	20	epithelial	epithelial	JJ
cord-296585-yfh5d4io	641	21	cells	cell	NNS
cord-296585-yfh5d4io	642	1	Low	low	JJ
cord-296585-yfh5d4io	642	2	-	-	HYPH
cord-296585-yfh5d4io	642	3	dose	dose	NN
cord-296585-yfh5d4io	642	4	azithromycin	azithromycin	NN
cord-296585-yfh5d4io	642	5	improves	improve	VBZ
cord-296585-yfh5d4io	642	6	phagocytosis	phagocytosis	NN
cord-296585-yfh5d4io	642	7	of	of	IN
cord-296585-yfh5d4io	642	8	bacteria	bacteria	NNS
cord-296585-yfh5d4io	642	9	by	by	IN
cord-296585-yfh5d4io	642	10	both	both	CC
cord-296585-yfh5d4io	642	11	alveolar	alveolar	NN
cord-296585-yfh5d4io	642	12	and	and	CC
cord-296585-yfh5d4io	642	13	monocyte	monocyte	NN
cord-296585-yfh5d4io	642	14	-	-	HYPH
cord-296585-yfh5d4io	642	15	derived	derive	VBN
cord-296585-yfh5d4io	642	16	macrophages	macrophage	NNS
cord-296585-yfh5d4io	642	17	in	in	IN
cord-296585-yfh5d4io	642	18	chronic	chronic	JJ
cord-296585-yfh5d4io	642	19	obstructive	obstructive	JJ
cord-296585-yfh5d4io	642	20	pulmonary	pulmonary	JJ
cord-296585-yfh5d4io	642	21	disease	disease	NN
cord-296585-yfh5d4io	642	22	subjects	subject	NNS
cord-296585-yfh5d4io	642	23	Relationship	relationship	NN
cord-296585-yfh5d4io	642	24	between	between	IN
cord-296585-yfh5d4io	642	25	azithromycin	azithromycin	NNP
cord-296585-yfh5d4io	642	26	susceptibility	susceptibility	NN
cord-296585-yfh5d4io	642	27	and	and	CC
cord-296585-yfh5d4io	642	28	administration	administration	NN
cord-296585-yfh5d4io	642	29	efficacy	efficacy	NN
cord-296585-yfh5d4io	642	30	for	for	IN
cord-296585-yfh5d4io	642	31	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	642	32	Haemophilus	Haemophilus	NNP
cord-296585-yfh5d4io	642	33	influenzae	influenzae	NN
cord-296585-yfh5d4io	642	34	respiratory	respiratory	JJ
cord-296585-yfh5d4io	642	35	infection	infection	NN
cord-296585-yfh5d4io	643	1	Nonantibiotic	nonantibiotic	JJ
cord-296585-yfh5d4io	643	2	macrolides	macrolide	NNS
cord-296585-yfh5d4io	643	3	restore	restore	VBP
cord-296585-yfh5d4io	643	4	airway	airway	NN
cord-296585-yfh5d4io	643	5	macrophage	macrophage	NN
cord-296585-yfh5d4io	643	6	phagocytic	phagocytic	JJ
cord-296585-yfh5d4io	643	7	function	function	NN
cord-296585-yfh5d4io	643	8	with	with	IN
cord-296585-yfh5d4io	643	9	potential	potential	JJ
cord-296585-yfh5d4io	643	10	anti	anti	JJ
cord-296585-yfh5d4io	643	11	-	-	JJ
cord-296585-yfh5d4io	643	12	inflammatory	inflammatory	JJ
cord-296585-yfh5d4io	643	13	effects	effect	NNS
cord-296585-yfh5d4io	643	14	in	in	IN
cord-296585-yfh5d4io	643	15	chronic	chronic	JJ
cord-296585-yfh5d4io	643	16	lung	lung	NN
cord-296585-yfh5d4io	643	17	diseases	disease	NNS
cord-296585-yfh5d4io	643	18	Vaccines	vaccine	NNS
cord-296585-yfh5d4io	643	19	for	for	IN
cord-296585-yfh5d4io	643	20	nontypeable	nontypeable	JJ
cord-296585-yfh5d4io	643	21	Haemophilus	haemophilus	JJ
cord-296585-yfh5d4io	643	22	influenzae	influenzae	NN
cord-296585-yfh5d4io	643	23	:	:	:
cord-296585-yfh5d4io	643	24	the	the	DT
cord-296585-yfh5d4io	643	25	future	future	NN
cord-296585-yfh5d4io	643	26	is	be	VBZ
cord-296585-yfh5d4io	643	27	now	now	RB
cord-296585-yfh5d4io	643	28	We	-PRON-	PRP
cord-296585-yfh5d4io	643	29	thank	thank	VBP
cord-296585-yfh5d4io	643	30	the	the	DT
cord-296585-yfh5d4io	643	31	following	follow	VBG
cord-296585-yfh5d4io	643	32	funding	funding	NN
cord-296585-yfh5d4io	643	33	agencies	agency	NNS
cord-296585-yfh5d4io	643	34	for	for	IN
cord-296585-yfh5d4io	643	35	their	-PRON-	PRP$
cord-296585-yfh5d4io	643	36	financial	financial	JJ
cord-296585-yfh5d4io	643	37	support	support	NN
cord-296585-yfh5d4io	643	38	during	during	IN
cord-296585-yfh5d4io	643	39	the	the	DT
cord-296585-yfh5d4io	643	40	preparation	preparation	NN
cord-296585-yfh5d4io	643	41	of	of	IN
cord-296585-yfh5d4io	643	42	the	the	DT
cord-296585-yfh5d4io	643	43	manuscript	manuscript	NN
cord-296585-yfh5d4io	643	44	.	.	.
cord-296585-yfh5d4io	644	1	They	-PRON-	PRP
cord-296585-yfh5d4io	644	2	are	be	VBP
cord-296585-yfh5d4io	644	3	the	the	DT
cord-296585-yfh5d4io	644	4	Alfred	Alfred	NNP
cord-296585-yfh5d4io	644	5	Österlund	Österlund	NNP
cord-296585-yfh5d4io	644	6	,	,	,
cord-296585-yfh5d4io	644	7	the	the	DT
cord-296585-yfh5d4io	644	8	Anna	Anna	NNP
cord-296585-yfh5d4io	644	9	and	and	CC
cord-296585-yfh5d4io	644	10	Edwin	Edwin	NNP
cord-296585-yfh5d4io	644	11	Berger	Berger	NNP
cord-296585-yfh5d4io	644	12	,	,	,
cord-296585-yfh5d4io	644	13	the	the	DT
cord-296585-yfh5d4io	644	14	Swedish	Swedish	NNP
cord-296585-yfh5d4io	644	15	Medical	Medical	NNP
cord-296585-yfh5d4io	644	16	Research	Research	NNP
cord-296585-yfh5d4io	644	17	Council	Council	NNP
cord-296585-yfh5d4io	645	1	(	(	-LRB-
cord-296585-yfh5d4io	645	2	grant	grant	NN
cord-296585-yfh5d4io	645	3	number	number	NN
cord-296585-yfh5d4io	645	4	K2015	K2015	NNP
cord-296585-yfh5d4io	645	5	-	-	HYPH
cord-296585-yfh5d4io	645	6	57X-03163	57x-03163	CD
cord-296585-yfh5d4io	645	7	-	-	HYPH
cord-296585-yfh5d4io	645	8	43	43	CD
cord-296585-yfh5d4io	645	9	-	-	SYM
cord-296585-yfh5d4io	645	10	4	4	CD
cord-296585-yfh5d4io	645	11	,	,	,
cord-296585-yfh5d4io	645	12	www.vr.se	www.vr.se	NNP
cord-296585-yfh5d4io	645	13	)	)	-RRB-
cord-296585-yfh5d4io	645	14	,	,	.
cord-296585-yfh5d4io	646	1	the	the	DT
cord-296585-yfh5d4io	646	2	Physiographical	Physiographical	NNP
cord-296585-yfh5d4io	646	3	Society	Society	NNP
cord-296585-yfh5d4io	646	4	(	(	-LRB-
cord-296585-yfh5d4io	646	5	Forssman	Forssman	NNP
cord-296585-yfh5d4io	646	6	's	's	POS
cord-296585-yfh5d4io	646	7	Foundation	Foundation	NNP
cord-296585-yfh5d4io	646	8	and	and	CC
cord-296585-yfh5d4io	646	9	,	,	,
cord-296585-yfh5d4io	646	10	Endowments	endowment	NNS
cord-296585-yfh5d4io	646	11	for	for	IN
cord-296585-yfh5d4io	646	12	the	the	DT
cord-296585-yfh5d4io	646	13	Natural	Natural	NNP
cord-296585-yfh5d4io	646	14	Sciences	Sciences	NNPS
cord-296585-yfh5d4io	646	15	,	,	,
cord-296585-yfh5d4io	646	16	Medicine	Medicine	NNP
cord-296585-yfh5d4io	646	17	and	and	CC
cord-296585-yfh5d4io	646	18	Technology	Technology	NNP
cord-296585-yfh5d4io	646	19	)	)	-RRB-
cord-296585-yfh5d4io	646	20	,	,	,
cord-296585-yfh5d4io	646	21	Skåne	Skåne	NNP
cord-296585-yfh5d4io	646	22	County	County	NNP
cord-296585-yfh5d4io	646	23	Council	Council	NNP
cord-296585-yfh5d4io	646	24	's	's	POS
cord-296585-yfh5d4io	646	25	research	research	NN
cord-296585-yfh5d4io	646	26	and	and	CC
cord-296585-yfh5d4io	646	27	development	development	NN
cord-296585-yfh5d4io	646	28	foundation	foundation	NN
cord-296585-yfh5d4io	646	29	,	,	,
cord-296585-yfh5d4io	646	30	and	and	CC
cord-296585-yfh5d4io	646	31	Heart	Heart	NNP
cord-296585-yfh5d4io	646	32	Lung	Lung	NNP
cord-296585-yfh5d4io	646	33	Foundation	Foundation	NNP
cord-296585-yfh5d4io	646	34	(	(	-LRB-
cord-296585-yfh5d4io	646	35	KR	KR	NNP
cord-296585-yfh5d4io	646	36	:	:	:
cord-296585-yfh5d4io	646	37	grant	grant	NN
cord-296585-yfh5d4io	646	38	number	number	NN
cord-296585-yfh5d4io	646	39	20150697	20150697	CD
cord-296585-yfh5d4io	646	40	,	,	,
cord-296585-yfh5d4io	646	41	www.hjart-lungfonden.se	www.hjart-lungfonden.se	NNP
cord-296585-yfh5d4io	646	42	)	)	-RRB-
cord-296585-yfh5d4io	646	43	.	.	.
cord-296585-yfh5d4io	647	1	The	the	DT
cord-296585-yfh5d4io	647	2	authors	author	NNS
cord-296585-yfh5d4io	647	3	declare	declare	VBP
cord-296585-yfh5d4io	647	4	that	that	IN
cord-296585-yfh5d4io	647	5	the	the	DT
cord-296585-yfh5d4io	647	6	research	research	NN
cord-296585-yfh5d4io	647	7	was	be	VBD
cord-296585-yfh5d4io	647	8	conducted	conduct	VBN
cord-296585-yfh5d4io	647	9	in	in	IN
cord-296585-yfh5d4io	647	10	the	the	DT
cord-296585-yfh5d4io	647	11	absence	absence	NN
cord-296585-yfh5d4io	647	12	of	of	IN
cord-296585-yfh5d4io	647	13	any	any	DT
cord-296585-yfh5d4io	647	14	commercial	commercial	JJ
cord-296585-yfh5d4io	647	15	or	or	CC
cord-296585-yfh5d4io	647	16	financial	financial	JJ
cord-296585-yfh5d4io	647	17	relationships	relationship	NNS
cord-296585-yfh5d4io	647	18	that	that	WDT
cord-296585-yfh5d4io	647	19	could	could	MD
cord-296585-yfh5d4io	647	20	be	be	VB
cord-296585-yfh5d4io	647	21	construed	construe	VBN
cord-296585-yfh5d4io	647	22	as	as	IN
cord-296585-yfh5d4io	647	23	a	a	DT
cord-296585-yfh5d4io	647	24	potential	potential	JJ
cord-296585-yfh5d4io	647	25	conflict	conflict	NN
cord-296585-yfh5d4io	647	26	of	of	IN
cord-296585-yfh5d4io	647	27	interest	interest	NN
cord-296585-yfh5d4io	647	28	.	.	.
cord-296585-yfh5d4io	648	1	Copyright	copyright	NN
cord-296585-yfh5d4io	649	1	©	©	NN
cord-296585-yfh5d4io	649	2	2018	2018	CD
cord-296585-yfh5d4io	649	3	Su	Su	NNP
cord-296585-yfh5d4io	649	4	,	,	,
cord-296585-yfh5d4io	649	5	Jalalvand	Jalalvand	NNP
cord-296585-yfh5d4io	649	6	,	,	,
cord-296585-yfh5d4io	649	7	Thegerström	Thegerström	NNP
cord-296585-yfh5d4io	649	8	and	and	CC
cord-296585-yfh5d4io	649	9	Riesbeck	Riesbeck	NNP
cord-296585-yfh5d4io	649	10	.	.	.
cord-296585-yfh5d4io	650	1	This	this	DT
cord-296585-yfh5d4io	650	2	is	be	VBZ
cord-296585-yfh5d4io	650	3	an	an	DT
cord-296585-yfh5d4io	650	4	open	open	JJ
cord-296585-yfh5d4io	650	5	-	-	HYPH
cord-296585-yfh5d4io	650	6	access	access	NN
cord-296585-yfh5d4io	650	7	article	article	NN
cord-296585-yfh5d4io	650	8	distributed	distribute	VBN
cord-296585-yfh5d4io	650	9	under	under	IN
cord-296585-yfh5d4io	650	10	the	the	DT
cord-296585-yfh5d4io	650	11	terms	term	NNS
cord-296585-yfh5d4io	650	12	of	of	IN
cord-296585-yfh5d4io	650	13	the	the	DT
cord-296585-yfh5d4io	650	14	Creative	Creative	NNP
cord-296585-yfh5d4io	650	15	Commons	Commons	NNP
cord-296585-yfh5d4io	650	16	Attribution	Attribution	NNP
cord-296585-yfh5d4io	650	17	License	License	NNP
cord-296585-yfh5d4io	650	18	(	(	-LRB-
cord-296585-yfh5d4io	650	19	CC	CC	NNP
cord-296585-yfh5d4io	650	20	BY	BY	NNP
cord-296585-yfh5d4io	650	21	)	)	-RRB-
cord-296585-yfh5d4io	650	22	.	.	.
cord-296585-yfh5d4io	651	1	The	the	DT
cord-296585-yfh5d4io	651	2	use	use	NN
cord-296585-yfh5d4io	651	3	,	,	,
cord-296585-yfh5d4io	651	4	distribution	distribution	NN
cord-296585-yfh5d4io	651	5	or	or	CC
cord-296585-yfh5d4io	651	6	reproduction	reproduction	NN
cord-296585-yfh5d4io	651	7	in	in	IN
cord-296585-yfh5d4io	651	8	other	other	JJ
cord-296585-yfh5d4io	651	9	forums	forum	NNS
cord-296585-yfh5d4io	651	10	is	be	VBZ
cord-296585-yfh5d4io	651	11	permitted	permit	VBN
cord-296585-yfh5d4io	651	12	,	,	,
cord-296585-yfh5d4io	651	13	provided	provide	VBD
cord-296585-yfh5d4io	651	14	the	the	DT
cord-296585-yfh5d4io	651	15	original	original	JJ
cord-296585-yfh5d4io	651	16	author(s	author(s	NNP
cord-296585-yfh5d4io	651	17	)	)	-RRB-
cord-296585-yfh5d4io	651	18	and	and	CC
cord-296585-yfh5d4io	651	19	the	the	DT
cord-296585-yfh5d4io	651	20	copyright	copyright	NN
cord-296585-yfh5d4io	651	21	owner(s	owner(s	NNP
cord-296585-yfh5d4io	651	22	)	)	-RRB-
cord-296585-yfh5d4io	651	23	are	be	VBP
cord-296585-yfh5d4io	651	24	credited	credit	VBN
cord-296585-yfh5d4io	651	25	and	and	CC
cord-296585-yfh5d4io	651	26	that	that	IN
cord-296585-yfh5d4io	651	27	the	the	DT
cord-296585-yfh5d4io	651	28	original	original	JJ
cord-296585-yfh5d4io	651	29	publication	publication	NN
cord-296585-yfh5d4io	651	30	in	in	IN
cord-296585-yfh5d4io	651	31	this	this	DT
cord-296585-yfh5d4io	651	32	journal	journal	NN
cord-296585-yfh5d4io	651	33	is	be	VBZ
cord-296585-yfh5d4io	651	34	cited	cite	VBN
cord-296585-yfh5d4io	651	35	,	,	,
cord-296585-yfh5d4io	651	36	in	in	IN
cord-296585-yfh5d4io	651	37	accordance	accordance	NN
cord-296585-yfh5d4io	651	38	with	with	IN
cord-296585-yfh5d4io	651	39	accepted	accepted	JJ
cord-296585-yfh5d4io	651	40	academic	academic	JJ
cord-296585-yfh5d4io	651	41	practice	practice	NN
cord-296585-yfh5d4io	651	42	.	.	.
cord-296585-yfh5d4io	652	1	No	no	DT
cord-296585-yfh5d4io	652	2	use	use	NN
cord-296585-yfh5d4io	652	3	,	,	,
cord-296585-yfh5d4io	652	4	distribution	distribution	NN
cord-296585-yfh5d4io	652	5	or	or	CC
cord-296585-yfh5d4io	652	6	reproduction	reproduction	NN
cord-296585-yfh5d4io	652	7	is	be	VBZ
cord-296585-yfh5d4io	652	8	permitted	permit	VBN
cord-296585-yfh5d4io	652	9	which	which	WDT
cord-296585-yfh5d4io	652	10	does	do	VBZ
cord-296585-yfh5d4io	652	11	not	not	RB
cord-296585-yfh5d4io	652	12	comply	comply	VB
cord-296585-yfh5d4io	652	13	with	with	IN
cord-296585-yfh5d4io	652	14	these	these	DT
cord-296585-yfh5d4io	652	15	terms	term	NNS
cord-296585-yfh5d4io	652	16	.	.	.