id sid tid token lemma pos cord-346964-9afuen7k 1 1 key key JJ cord-346964-9afuen7k 1 2 : : : cord-346964-9afuen7k 1 3 cord-346964 cord-346964 NN cord-346964-9afuen7k 1 4 - - HYPH cord-346964-9afuen7k 1 5 9afuen7k 9afuen7k CD cord-346964-9afuen7k 1 6 authors author NNS cord-346964-9afuen7k 1 7 : : : cord-346964-9afuen7k 1 8 Ensari Ensari NNP cord-346964-9afuen7k 1 9 , , , cord-346964-9afuen7k 1 10 A. a. NN cord-346964-9afuen7k 1 11 title title NN cord-346964-9afuen7k 1 12 : : : cord-346964-9afuen7k 1 13 The the DT cord-346964-9afuen7k 1 14 Malabsorption Malabsorption NNP cord-346964-9afuen7k 1 15 Syndrome Syndrome NNP cord-346964-9afuen7k 1 16 and and CC cord-346964-9afuen7k 1 17 Its -PRON- PRP$ cord-346964-9afuen7k 1 18 Causes cause NNS cord-346964-9afuen7k 1 19 and and CC cord-346964-9afuen7k 1 20 Consequences consequence NNS cord-346964-9afuen7k 1 21 date date NN cord-346964-9afuen7k 1 22 : : : cord-346964-9afuen7k 1 23 2014 2014 CD cord-346964-9afuen7k 1 24 - - HYPH cord-346964-9afuen7k 1 25 08 08 CD cord-346964-9afuen7k 1 26 - - SYM cord-346964-9afuen7k 1 27 21 21 CD cord-346964-9afuen7k 1 28 journal journal NN cord-346964-9afuen7k 1 29 : : : cord-346964-9afuen7k 1 30 Pathobiology Pathobiology NNP cord-346964-9afuen7k 1 31 of of IN cord-346964-9afuen7k 1 32 Human Human NNP cord-346964-9afuen7k 1 33 Disease Disease NNP cord-346964-9afuen7k 1 34 DOI DOI NNP cord-346964-9afuen7k 1 35 : : : cord-346964-9afuen7k 1 36 10.1016 10.1016 CD cord-346964-9afuen7k 1 37 / / SYM cord-346964-9afuen7k 1 38 b978 b978 NN cord-346964-9afuen7k 1 39 - - HYPH cord-346964-9afuen7k 1 40 0 0 CD cord-346964-9afuen7k 1 41 - - HYPH cord-346964-9afuen7k 1 42 12 12 CD cord-346964-9afuen7k 1 43 - - HYPH cord-346964-9afuen7k 1 44 386456 386456 CD cord-346964-9afuen7k 1 45 - - HYPH cord-346964-9afuen7k 1 46 7.03804 7.03804 CD cord-346964-9afuen7k 1 47 - - HYPH cord-346964-9afuen7k 1 48 1 1 CD cord-346964-9afuen7k 1 49 sha sha NN cord-346964-9afuen7k 1 50 : : : cord-346964-9afuen7k 2 1 3c32d329efdcc9bd98f5abd5411d2824948e7b35 3c32d329efdcc9bd98f5abd5411d2824948e7b35 NNP cord-346964-9afuen7k 2 2 doc_id doc_id CD cord-346964-9afuen7k 2 3 : : : cord-346964-9afuen7k 2 4 346964 346964 CD cord-346964-9afuen7k 2 5 cord_uid cord_uid NNS cord-346964-9afuen7k 2 6 : : : cord-346964-9afuen7k 2 7 9afuen7k 9afuen7k ADD cord-346964-9afuen7k 3 1 The the DT cord-346964-9afuen7k 3 2 indication indication NN cord-346964-9afuen7k 3 3 for for IN cord-346964-9afuen7k 3 4 a a DT cord-346964-9afuen7k 3 5 small small JJ cord-346964-9afuen7k 3 6 intestinal intestinal JJ cord-346964-9afuen7k 3 7 biopsy biopsy NN cord-346964-9afuen7k 3 8 is be VBZ cord-346964-9afuen7k 3 9 usually usually RB cord-346964-9afuen7k 3 10 the the DT cord-346964-9afuen7k 3 11 work work NN cord-346964-9afuen7k 3 12 - - HYPH cord-346964-9afuen7k 3 13 up up NN cord-346964-9afuen7k 3 14 of of IN cord-346964-9afuen7k 3 15 malabsorption malabsorption NN cord-346964-9afuen7k 3 16 , , , cord-346964-9afuen7k 3 17 a a DT cord-346964-9afuen7k 3 18 clinicopathologic clinicopathologic JJ cord-346964-9afuen7k 3 19 picture picture NN cord-346964-9afuen7k 3 20 caused cause VBN cord-346964-9afuen7k 3 21 by by IN cord-346964-9afuen7k 3 22 a a DT cord-346964-9afuen7k 3 23 number number NN cord-346964-9afuen7k 3 24 of of IN cord-346964-9afuen7k 3 25 infectious infectious JJ cord-346964-9afuen7k 3 26 and and CC cord-346964-9afuen7k 3 27 noninfectious noninfectious JJ cord-346964-9afuen7k 3 28 inflammatory inflammatory JJ cord-346964-9afuen7k 3 29 conditions condition NNS cord-346964-9afuen7k 3 30 . . . cord-346964-9afuen7k 4 1 The the DT cord-346964-9afuen7k 4 2 biopsy biopsy NN cord-346964-9afuen7k 4 3 is be VBZ cord-346964-9afuen7k 4 4 generally generally RB cord-346964-9afuen7k 4 5 taken take VBN cord-346964-9afuen7k 4 6 through through IN cord-346964-9afuen7k 4 7 an an DT cord-346964-9afuen7k 4 8 endoscope endoscope NN cord-346964-9afuen7k 4 9 , , , cord-346964-9afuen7k 4 10 by by IN cord-346964-9afuen7k 4 11 either either CC cord-346964-9afuen7k 4 12 forceps forceps NNS cord-346964-9afuen7k 4 13 or or CC cord-346964-9afuen7k 4 14 suction suction NN cord-346964-9afuen7k 4 15 , , , cord-346964-9afuen7k 4 16 from from IN cord-346964-9afuen7k 4 17 the the DT cord-346964-9afuen7k 4 18 duodenum duodenum NN cord-346964-9afuen7k 4 19 or or CC cord-346964-9afuen7k 4 20 proximal proximal JJ cord-346964-9afuen7k 4 21 jejunum jejunum NNS cord-346964-9afuen7k 4 22 . . . cord-346964-9afuen7k 5 1 Depending depend VBG cord-346964-9afuen7k 5 2 upon upon IN cord-346964-9afuen7k 5 3 the the DT cord-346964-9afuen7k 5 4 underlying underlying JJ cord-346964-9afuen7k 5 5 condition condition NN cord-346964-9afuen7k 5 6 , , , cord-346964-9afuen7k 5 7 morphological morphological JJ cord-346964-9afuen7k 5 8 abnormalities abnormality NNS cord-346964-9afuen7k 5 9 are be VBP cord-346964-9afuen7k 5 10 seen see VBN cord-346964-9afuen7k 5 11 in in IN cord-346964-9afuen7k 5 12 malabsorption malabsorption NN cord-346964-9afuen7k 5 13 range range NN cord-346964-9afuen7k 5 14 from from IN cord-346964-9afuen7k 5 15 normal normal JJ cord-346964-9afuen7k 5 16 mucosa mucosa NN cord-346964-9afuen7k 5 17 with with IN cord-346964-9afuen7k 5 18 increased increase VBN cord-346964-9afuen7k 5 19 intraepithelial intraepithelial JJ cord-346964-9afuen7k 5 20 lymphocytes lymphocyte NNS cord-346964-9afuen7k 5 21 ( ( -LRB- cord-346964-9afuen7k 5 22 gluten gluten NN cord-346964-9afuen7k 5 23 - - HYPH cord-346964-9afuen7k 5 24 sensitive sensitive JJ cord-346964-9afuen7k 5 25 enteropathy enteropathy NNS cord-346964-9afuen7k 5 26 , , , cord-346964-9afuen7k 5 27 viral viral JJ cord-346964-9afuen7k 5 28 gastroenteritis gastroenteritis NN cord-346964-9afuen7k 5 29 , , , cord-346964-9afuen7k 5 30 food food NN cord-346964-9afuen7k 5 31 allergies allergy NNS cord-346964-9afuen7k 5 32 , , , cord-346964-9afuen7k 5 33 etc etc FW cord-346964-9afuen7k 5 34 . . . cord-346964-9afuen7k 5 35 ) ) -RRB- cord-346964-9afuen7k 5 36 , , , cord-346964-9afuen7k 5 37 villous villous NNP cord-346964-9afuen7k 5 38 shortening shorten VBG cord-346964-9afuen7k 5 39 with with IN cord-346964-9afuen7k 5 40 crypt crypt JJ cord-346964-9afuen7k 5 41 hyperplasia hyperplasia NN cord-346964-9afuen7k 5 42 ( ( -LRB- cord-346964-9afuen7k 5 43 celiac celiac JJ cord-346964-9afuen7k 5 44 disease disease NN cord-346964-9afuen7k 5 45 ( ( -LRB- cord-346964-9afuen7k 5 46 CD CD NNP cord-346964-9afuen7k 5 47 ) ) -RRB- cord-346964-9afuen7k 5 48 , , , cord-346964-9afuen7k 5 49 treated treat VBN cord-346964-9afuen7k 5 50 CD CD NNP cord-346964-9afuen7k 5 51 , , , cord-346964-9afuen7k 5 52 tropical tropical JJ cord-346964-9afuen7k 5 53 sprue sprue NN cord-346964-9afuen7k 5 54 , , , cord-346964-9afuen7k 5 55 and and CC cord-346964-9afuen7k 5 56 bacterial bacterial JJ cord-346964-9afuen7k 5 57 overgrowth overgrowth NN cord-346964-9afuen7k 5 58 ) ) -RRB- cord-346964-9afuen7k 5 59 , , , cord-346964-9afuen7k 5 60 to to TO cord-346964-9afuen7k 5 61 completely completely RB cord-346964-9afuen7k 5 62 flat flat JJ cord-346964-9afuen7k 5 63 mucosa mucosa JJ cord-346964-9afuen7k 5 64 ( ( -LRB- cord-346964-9afuen7k 5 65 CD cd NN cord-346964-9afuen7k 5 66 , , , cord-346964-9afuen7k 5 67 refractory refractory JJ cord-346964-9afuen7k 5 68 sprue sprue NN cord-346964-9afuen7k 5 69 , , , cord-346964-9afuen7k 5 70 enteropathy enteropathy NNP cord-346964-9afuen7k 5 71 - - HYPH cord-346964-9afuen7k 5 72 induced induce VBN cord-346964-9afuen7k 5 73 T t NN cord-346964-9afuen7k 5 74 - - HYPH cord-346964-9afuen7k 5 75 cell cell NN cord-346964-9afuen7k 5 76 lymphoma lymphoma NN cord-346964-9afuen7k 5 77 , , , cord-346964-9afuen7k 5 78 and and CC cord-346964-9afuen7k 5 79 autoimmune autoimmune JJ cord-346964-9afuen7k 5 80 enteropathy enteropathy NNP cord-346964-9afuen7k 5 81 ) ) -RRB- cord-346964-9afuen7k 5 82 . . . cord-346964-9afuen7k 6 1 Infectious infectious JJ cord-346964-9afuen7k 6 2 agents agent NNS cord-346964-9afuen7k 6 3 that that WDT cord-346964-9afuen7k 6 4 affect affect VBP cord-346964-9afuen7k 6 5 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 6 6 tract tract NN cord-346964-9afuen7k 6 7 can can MD cord-346964-9afuen7k 6 8 be be VB cord-346964-9afuen7k 6 9 grouped group VBN cord-346964-9afuen7k 6 10 as as IN cord-346964-9afuen7k 6 11 food food NN cord-346964-9afuen7k 6 12 - - HYPH cord-346964-9afuen7k 6 13 borne bear VBN cord-346964-9afuen7k 6 14 and and CC cord-346964-9afuen7k 6 15 water water NN cord-346964-9afuen7k 6 16 - - HYPH cord-346964-9afuen7k 6 17 borne bear VBN cord-346964-9afuen7k 6 18 bacteria bacteria NNS cord-346964-9afuen7k 6 19 , , , cord-346964-9afuen7k 6 20 opportunistic opportunistic JJ cord-346964-9afuen7k 6 21 infections infection NNS cord-346964-9afuen7k 6 22 ( ( -LRB- cord-346964-9afuen7k 6 23 bacterial bacterial JJ cord-346964-9afuen7k 6 24 , , , cord-346964-9afuen7k 6 25 fungal fungal JJ cord-346964-9afuen7k 6 26 , , , cord-346964-9afuen7k 6 27 and and CC cord-346964-9afuen7k 6 28 viral viral JJ cord-346964-9afuen7k 6 29 ) ) -RRB- cord-346964-9afuen7k 6 30 , , , cord-346964-9afuen7k 6 31 viral viral JJ cord-346964-9afuen7k 6 32 infections infection NNS cord-346964-9afuen7k 6 33 ( ( -LRB- cord-346964-9afuen7k 6 34 extremely extremely RB cord-346964-9afuen7k 6 35 rarely rarely RB cord-346964-9afuen7k 6 36 biopsied biopsied JJ cord-346964-9afuen7k 6 37 ) ) -RRB- cord-346964-9afuen7k 6 38 , , , cord-346964-9afuen7k 6 39 and and CC cord-346964-9afuen7k 6 40 parasitic parasitic JJ cord-346964-9afuen7k 6 41 and and CC cord-346964-9afuen7k 6 42 helminthic helminthic JJ cord-346964-9afuen7k 6 43 infections infection NNS cord-346964-9afuen7k 6 44 . . . cord-346964-9afuen7k 7 1 The the DT cord-346964-9afuen7k 7 2 majority majority NN cord-346964-9afuen7k 7 3 of of IN cord-346964-9afuen7k 7 4 these these DT cord-346964-9afuen7k 7 5 infections infection NNS cord-346964-9afuen7k 7 6 are be VBP cord-346964-9afuen7k 7 7 , , , cord-346964-9afuen7k 7 8 however however RB cord-346964-9afuen7k 7 9 , , , cord-346964-9afuen7k 7 10 self self NN cord-346964-9afuen7k 7 11 - - HYPH cord-346964-9afuen7k 7 12 limited limit VBN cord-346964-9afuen7k 7 13 . . . cord-346964-9afuen7k 8 1 Although although IN cord-346964-9afuen7k 8 2 biopsy biopsy NN cord-346964-9afuen7k 8 3 is be VBZ cord-346964-9afuen7k 8 4 more more RBR cord-346964-9afuen7k 8 5 invasive invasive JJ cord-346964-9afuen7k 8 6 , , , cord-346964-9afuen7k 8 7 the the DT cord-346964-9afuen7k 8 8 use use NN cord-346964-9afuen7k 8 9 of of IN cord-346964-9afuen7k 8 10 this this DT cord-346964-9afuen7k 8 11 procedure procedure NN cord-346964-9afuen7k 8 12 allows allow VBZ cord-346964-9afuen7k 8 13 detection detection NN cord-346964-9afuen7k 8 14 of of IN cord-346964-9afuen7k 8 15 other other JJ cord-346964-9afuen7k 8 16 causes cause NNS cord-346964-9afuen7k 8 17 , , , cord-346964-9afuen7k 8 18 including include VBG cord-346964-9afuen7k 8 19 Whipple Whipple NNP cord-346964-9afuen7k 8 20 's 's POS cord-346964-9afuen7k 8 21 disease disease NN cord-346964-9afuen7k 8 22 , , , cord-346964-9afuen7k 8 23 other other JJ cord-346964-9afuen7k 8 24 protozoan protozoan NN cord-346964-9afuen7k 8 25 forms form NNS cord-346964-9afuen7k 8 26 of of IN cord-346964-9afuen7k 8 27 diarrhea diarrhea NN cord-346964-9afuen7k 8 28 ( ( -LRB- cord-346964-9afuen7k 8 29 e.g. e.g. RB cord-346964-9afuen7k 8 30 , , , cord-346964-9afuen7k 8 31 cryptosporidiosis cryptosporidiosis NNP cord-346964-9afuen7k 8 32 , , , cord-346964-9afuen7k 8 33 isosporiasis isosporiasis NNP cord-346964-9afuen7k 8 34 , , , cord-346964-9afuen7k 8 35 or or CC cord-346964-9afuen7k 8 36 cyclosporiasis cyclosporiasis NNP cord-346964-9afuen7k 8 37 ) ) -RRB- cord-346964-9afuen7k 8 38 , , , cord-346964-9afuen7k 8 39 Crohn Crohn NNP cord-346964-9afuen7k 8 40 's 's POS cord-346964-9afuen7k 8 41 disease disease NN cord-346964-9afuen7k 8 42 , , , cord-346964-9afuen7k 8 43 or or CC cord-346964-9afuen7k 8 44 lymphoma lymphoma NN cord-346964-9afuen7k 8 45 that that WDT cord-346964-9afuen7k 8 46 may may MD cord-346964-9afuen7k 8 47 also also RB cord-346964-9afuen7k 8 48 present present VB cord-346964-9afuen7k 8 49 as as IN cord-346964-9afuen7k 8 50 diarrhea diarrhea NN cord-346964-9afuen7k 8 51 and and CC cord-346964-9afuen7k 8 52 malabsorption malabsorption NN cord-346964-9afuen7k 8 53 . . . cord-346964-9afuen7k 9 1 The the DT cord-346964-9afuen7k 9 2 Malabsorption Malabsorption NNP cord-346964-9afuen7k 9 3 Syndrome Syndrome NNP cord-346964-9afuen7k 9 4 and and CC cord-346964-9afuen7k 9 5 Its -PRON- PRP$ cord-346964-9afuen7k 9 6 Causes cause NNS cord-346964-9afuen7k 9 7 and and CC cord-346964-9afuen7k 10 1 Consequences consequence NNS cord-346964-9afuen7k 10 2 A a DT cord-346964-9afuen7k 10 3 Ensari Ensari NNP cord-346964-9afuen7k 10 4 , , , cord-346964-9afuen7k 10 5 Ankara Ankara NNP cord-346964-9afuen7k 10 6 University University NNP cord-346964-9afuen7k 10 7 Medical Medical NNP cord-346964-9afuen7k 10 8 School School NNP cord-346964-9afuen7k 10 9 , , , cord-346964-9afuen7k 10 10 Ankara Ankara NNP cord-346964-9afuen7k 10 11 , , , cord-346964-9afuen7k 10 12 Turkey Turkey NNP cord-346964-9afuen7k 10 13 2014 2014 CD cord-346964-9afuen7k 11 1 Elsevier Elsevier NNP cord-346964-9afuen7k 11 2 Inc. Inc. NNP cord-346964-9afuen7k 11 3 All all DT cord-346964-9afuen7k 11 4 rights right NNS cord-346964-9afuen7k 11 5 reserved reserve VBN cord-346964-9afuen7k 11 6 . . . cord-346964-9afuen7k 12 1 Autoimmune autoimmune JJ cord-346964-9afuen7k 12 2 enteropathy enteropathy XX cord-346964-9afuen7k 13 1 This this DT cord-346964-9afuen7k 13 2 is be VBZ cord-346964-9afuen7k 13 3 a a DT cord-346964-9afuen7k 13 4 rare rare JJ cord-346964-9afuen7k 13 5 condition condition NN cord-346964-9afuen7k 13 6 caused cause VBN cord-346964-9afuen7k 13 7 by by IN cord-346964-9afuen7k 13 8 autoantibodies autoantibody NNS cord-346964-9afuen7k 13 9 to to TO cord-346964-9afuen7k 13 10 intestinal intestinal JJ cord-346964-9afuen7k 13 11 mucosa mucosa JJ cord-346964-9afuen7k 13 12 primarily primarily RB cord-346964-9afuen7k 13 13 affecting affect VBG cord-346964-9afuen7k 13 14 children child NNS cord-346964-9afuen7k 13 15 who who WP cord-346964-9afuen7k 13 16 suffer suffer VBP cord-346964-9afuen7k 13 17 from from IN cord-346964-9afuen7k 13 18 severe severe JJ cord-346964-9afuen7k 13 19 chronic chronic JJ cord-346964-9afuen7k 13 20 diarrhea diarrhea NN cord-346964-9afuen7k 13 21 within within IN cord-346964-9afuen7k 13 22 the the DT cord-346964-9afuen7k 13 23 first first JJ cord-346964-9afuen7k 13 24 months month NNS cord-346964-9afuen7k 13 25 of of IN cord-346964-9afuen7k 13 26 life life NN cord-346964-9afuen7k 13 27 . . . cord-346964-9afuen7k 14 1 Celiac celiac JJ cord-346964-9afuen7k 14 2 disease disease NN cord-346964-9afuen7k 14 3 Celiac Celiac NNP cord-346964-9afuen7k 14 4 disease disease NN cord-346964-9afuen7k 14 5 ( ( -LRB- cord-346964-9afuen7k 14 6 CD CD NNP cord-346964-9afuen7k 14 7 ) ) -RRB- cord-346964-9afuen7k 14 8 , , , cord-346964-9afuen7k 14 9 also also RB cord-346964-9afuen7k 14 10 known know VBN cord-346964-9afuen7k 14 11 as as IN cord-346964-9afuen7k 14 12 celiac celiac JJ cord-346964-9afuen7k 14 13 sprue sprue NN cord-346964-9afuen7k 14 14 , , , cord-346964-9afuen7k 14 15 nontropical nontropical JJ cord-346964-9afuen7k 14 16 sprue sprue NN cord-346964-9afuen7k 14 17 , , , cord-346964-9afuen7k 14 18 gluten gluten NN cord-346964-9afuen7k 14 19 - - HYPH cord-346964-9afuen7k 14 20 induced induce VBN cord-346964-9afuen7k 14 21 enteropathy enteropathy NNP cord-346964-9afuen7k 14 22 , , , cord-346964-9afuen7k 14 23 or or CC cord-346964-9afuen7k 14 24 gluten gluten NN cord-346964-9afuen7k 14 25 - - HYPH cord-346964-9afuen7k 14 26 sensitive sensitive JJ cord-346964-9afuen7k 14 27 enteropathy enteropathy NNS cord-346964-9afuen7k 14 28 ( ( -LRB- cord-346964-9afuen7k 14 29 GSE GSE NNP cord-346964-9afuen7k 14 30 ) ) -RRB- cord-346964-9afuen7k 14 31 , , , cord-346964-9afuen7k 14 32 is be VBZ cord-346964-9afuen7k 14 33 a a DT cord-346964-9afuen7k 14 34 chronic chronic JJ cord-346964-9afuen7k 14 35 inflammatory inflammatory JJ cord-346964-9afuen7k 14 36 disorder disorder NN cord-346964-9afuen7k 14 37 of of IN cord-346964-9afuen7k 14 38 the the DT cord-346964-9afuen7k 14 39 small small JJ cord-346964-9afuen7k 14 40 intestine intestine NN cord-346964-9afuen7k 14 41 induced induce VBN cord-346964-9afuen7k 14 42 by by IN cord-346964-9afuen7k 14 43 a a DT cord-346964-9afuen7k 14 44 T t NN cord-346964-9afuen7k 14 45 - - HYPH cord-346964-9afuen7k 14 46 cell cell NN cord-346964-9afuen7k 14 47 - - HYPH cord-346964-9afuen7k 14 48 mediated mediate VBN cord-346964-9afuen7k 14 49 immune immune JJ cord-346964-9afuen7k 14 50 response response NN cord-346964-9afuen7k 14 51 and and CC cord-346964-9afuen7k 14 52 characterized characterize VBN cord-346964-9afuen7k 14 53 by by IN cord-346964-9afuen7k 14 54 malabsorption malabsorption NN cord-346964-9afuen7k 14 55 after after IN cord-346964-9afuen7k 14 56 ingestion ingestion NN cord-346964-9afuen7k 14 57 of of IN cord-346964-9afuen7k 14 58 wheat wheat NN cord-346964-9afuen7k 14 59 gluten gluten NN cord-346964-9afuen7k 14 60 or or CC cord-346964-9afuen7k 14 61 related related JJ cord-346964-9afuen7k 14 62 proteins protein NNS cord-346964-9afuen7k 14 63 in in IN cord-346964-9afuen7k 14 64 rye rye NN cord-346964-9afuen7k 14 65 ( ( -LRB- cord-346964-9afuen7k 14 66 secalins secalins NNP cord-346964-9afuen7k 14 67 ) ) -RRB- cord-346964-9afuen7k 14 68 and and CC cord-346964-9afuen7k 14 69 barley barley NN cord-346964-9afuen7k 14 70 ( ( -LRB- cord-346964-9afuen7k 14 71 hordeins hordeins NNP cord-346964-9afuen7k 14 72 ) ) -RRB- cord-346964-9afuen7k 14 73 in in IN cord-346964-9afuen7k 14 74 individuals individual NNS cord-346964-9afuen7k 14 75 with with IN cord-346964-9afuen7k 14 76 a a DT cord-346964-9afuen7k 14 77 certain certain JJ cord-346964-9afuen7k 14 78 genetic genetic JJ cord-346964-9afuen7k 14 79 background background NN cord-346964-9afuen7k 14 80 . . . cord-346964-9afuen7k 15 1 Common common JJ cord-346964-9afuen7k 15 2 variable variable JJ cord-346964-9afuen7k 15 3 immunodeficiency immunodeficiency NN cord-346964-9afuen7k 15 4 ( ( -LRB- cord-346964-9afuen7k 15 5 CVID CVID NNP cord-346964-9afuen7k 15 6 ) ) -RRB- cord-346964-9afuen7k 16 1 CVID CVID NNP cord-346964-9afuen7k 16 2 is be VBZ cord-346964-9afuen7k 16 3 primarily primarily RB cord-346964-9afuen7k 16 4 a a DT cord-346964-9afuen7k 16 5 dysfunction dysfunction NN cord-346964-9afuen7k 16 6 of of IN cord-346964-9afuen7k 16 7 B b NN cord-346964-9afuen7k 16 8 - - HYPH cord-346964-9afuen7k 16 9 cell cell NN cord-346964-9afuen7k 16 10 differentiation differentiation NN cord-346964-9afuen7k 16 11 resulting result VBG cord-346964-9afuen7k 16 12 in in IN cord-346964-9afuen7k 16 13 hypogammaglobulinemia hypogammaglobulinemia NN cord-346964-9afuen7k 16 14 and and CC cord-346964-9afuen7k 16 15 diminished diminished JJ cord-346964-9afuen7k 16 16 ability ability NN cord-346964-9afuen7k 16 17 to to TO cord-346964-9afuen7k 16 18 produce produce VB cord-346964-9afuen7k 16 19 antibodies antibody NNS cord-346964-9afuen7k 16 20 . . . cord-346964-9afuen7k 17 1 Deamidation Deamidation NNP cord-346964-9afuen7k 17 2 Detachment Detachment NNP cord-346964-9afuen7k 17 3 of of IN cord-346964-9afuen7k 17 4 an an DT cord-346964-9afuen7k 17 5 amino amino NN cord-346964-9afuen7k 17 6 group group NN cord-346964-9afuen7k 17 7 by by IN cord-346964-9afuen7k 17 8 tissue tissue NN cord-346964-9afuen7k 17 9 transglutaminase transglutaminase NN cord-346964-9afuen7k 17 10 from from IN cord-346964-9afuen7k 17 11 gliadin gliadin NN cord-346964-9afuen7k 17 12 that that WDT cord-346964-9afuen7k 17 13 becomes become VBZ cord-346964-9afuen7k 17 14 negatively negatively RB cord-346964-9afuen7k 17 15 charged charge VBN cord-346964-9afuen7k 17 16 . . . cord-346964-9afuen7k 18 1 Enteroendocrine enteroendocrine JJ cord-346964-9afuen7k 18 2 cell cell NN cord-346964-9afuen7k 18 3 dysgenesis dysgenesis NN cord-346964-9afuen7k 19 1 This this DT cord-346964-9afuen7k 19 2 disorder disorder NN cord-346964-9afuen7k 19 3 is be VBZ cord-346964-9afuen7k 19 4 associated associate VBN cord-346964-9afuen7k 19 5 with with IN cord-346964-9afuen7k 19 6 neurogenin neurogenin NNP cord-346964-9afuen7k 19 7 3 3 CD cord-346964-9afuen7k 19 8 mutation mutation NN cord-346964-9afuen7k 19 9 that that WDT cord-346964-9afuen7k 19 10 is be VBZ cord-346964-9afuen7k 19 11 a a DT cord-346964-9afuen7k 19 12 protein protein NN cord-346964-9afuen7k 19 13 involved involve VBN cord-346964-9afuen7k 19 14 in in IN cord-346964-9afuen7k 19 15 gut gut NN cord-346964-9afuen7k 19 16 and and CC cord-346964-9afuen7k 19 17 pancreatic pancreatic JJ cord-346964-9afuen7k 19 18 endocrine endocrine JJ cord-346964-9afuen7k 19 19 cell cell NN cord-346964-9afuen7k 19 20 development development NN cord-346964-9afuen7k 19 21 , , , cord-346964-9afuen7k 19 22 located locate VBN cord-346964-9afuen7k 19 23 on on IN cord-346964-9afuen7k 19 24 chromosome chromosome NN cord-346964-9afuen7k 19 25 10q21.3 10q21.3 CD cord-346964-9afuen7k 19 26 . . . cord-346964-9afuen7k 20 1 Enteropathy Enteropathy NNP cord-346964-9afuen7k 20 2 - - HYPH cord-346964-9afuen7k 20 3 induced induce VBN cord-346964-9afuen7k 20 4 T t NN cord-346964-9afuen7k 20 5 - - HYPH cord-346964-9afuen7k 20 6 cell cell NN cord-346964-9afuen7k 20 7 lymphoma lymphoma NN cord-346964-9afuen7k 20 8 ( ( -LRB- cord-346964-9afuen7k 20 9 EITCL EITCL NNP cord-346964-9afuen7k 20 10 ) ) -RRB- cord-346964-9afuen7k 21 1 This this DT cord-346964-9afuen7k 21 2 highgrade highgrade JJ cord-346964-9afuen7k 21 3 T t NN cord-346964-9afuen7k 21 4 - - HYPH cord-346964-9afuen7k 21 5 cell cell NN cord-346964-9afuen7k 21 6 lymphoma lymphoma NN cord-346964-9afuen7k 21 7 is be VBZ cord-346964-9afuen7k 21 8 the the DT cord-346964-9afuen7k 21 9 most most RBS cord-346964-9afuen7k 21 10 fearsome fearsome JJ cord-346964-9afuen7k 21 11 complication complication NN cord-346964-9afuen7k 21 12 of of IN cord-346964-9afuen7k 21 13 CD cd NN cord-346964-9afuen7k 21 14 in in IN cord-346964-9afuen7k 21 15 patients patient NNS cord-346964-9afuen7k 21 16 with with IN cord-346964-9afuen7k 21 17 long long RB cord-346964-9afuen7k 21 18 - - HYPH cord-346964-9afuen7k 21 19 standing stand VBG cord-346964-9afuen7k 21 20 malabsorption malabsorption NN cord-346964-9afuen7k 21 21 . . . cord-346964-9afuen7k 22 1 Eosinophilic eosinophilic JJ cord-346964-9afuen7k 22 2 gastroenteritis gastroenteritis NN cord-346964-9afuen7k 23 1 This this DT cord-346964-9afuen7k 23 2 is be VBZ cord-346964-9afuen7k 23 3 a a DT cord-346964-9afuen7k 23 4 spectrum spectrum NN cord-346964-9afuen7k 23 5 of of IN cord-346964-9afuen7k 23 6 diseases disease NNS cord-346964-9afuen7k 23 7 characterized characterize VBN cord-346964-9afuen7k 23 8 by by IN cord-346964-9afuen7k 23 9 eosinophilic eosinophilic JJ cord-346964-9afuen7k 23 10 infiltration infiltration NN cord-346964-9afuen7k 23 11 of of IN cord-346964-9afuen7k 23 12 various various JJ cord-346964-9afuen7k 23 13 segments segment NNS cord-346964-9afuen7k 23 14 of of IN cord-346964-9afuen7k 23 15 the the DT cord-346964-9afuen7k 23 16 GI GI NNP cord-346964-9afuen7k 23 17 tract tract NN cord-346964-9afuen7k 23 18 together together RB cord-346964-9afuen7k 23 19 with with IN cord-346964-9afuen7k 23 20 peripheral peripheral JJ cord-346964-9afuen7k 23 21 eosinophilia eosinophilia NN cord-346964-9afuen7k 23 22 and and CC cord-346964-9afuen7k 23 23 coexisting coexist VBG cord-346964-9afuen7k 23 24 allergies allergy NNS cord-346964-9afuen7k 23 25 . . . cord-346964-9afuen7k 24 1 Graft graft NN cord-346964-9afuen7k 24 2 - - HYPH cord-346964-9afuen7k 24 3 versus versus IN cord-346964-9afuen7k 24 4 - - HYPH cord-346964-9afuen7k 24 5 host host NN cord-346964-9afuen7k 24 6 disease disease NN cord-346964-9afuen7k 24 7 ( ( -LRB- cord-346964-9afuen7k 24 8 GVHD GVHD NNP cord-346964-9afuen7k 24 9 ) ) -RRB- cord-346964-9afuen7k 25 1 Donor donor NN cord-346964-9afuen7k 25 2 T t NN cord-346964-9afuen7k 25 3 cells cell NNS cord-346964-9afuen7k 25 4 of of IN cord-346964-9afuen7k 25 5 cytotoxic cytotoxic JJ cord-346964-9afuen7k 25 6 subtype subtype NN cord-346964-9afuen7k 25 7 incite incite VBP cord-346964-9afuen7k 25 8 an an DT cord-346964-9afuen7k 25 9 immunologic immunologic JJ cord-346964-9afuen7k 25 10 reaction reaction NN cord-346964-9afuen7k 25 11 to to IN cord-346964-9afuen7k 25 12 certain certain JJ cord-346964-9afuen7k 25 13 host host NN cord-346964-9afuen7k 25 14 cells cell NNS cord-346964-9afuen7k 25 15 resulting result VBG cord-346964-9afuen7k 25 16 in in IN cord-346964-9afuen7k 25 17 injury injury NN cord-346964-9afuen7k 25 18 to to IN cord-346964-9afuen7k 25 19 GI GI NNP cord-346964-9afuen7k 25 20 mucosa mucosa NN cord-346964-9afuen7k 25 21 . . . cord-346964-9afuen7k 26 1 Gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 26 2 complications complication NNS cord-346964-9afuen7k 26 3 are be VBP cord-346964-9afuen7k 26 4 common common JJ cord-346964-9afuen7k 26 5 in in IN cord-346964-9afuen7k 26 6 bone bone NN cord-346964-9afuen7k 26 7 marrow marrow NN cord-346964-9afuen7k 26 8 transplant transplant NN cord-346964-9afuen7k 26 9 recipients recipient NNS cord-346964-9afuen7k 26 10 rather rather RB cord-346964-9afuen7k 26 11 than than IN cord-346964-9afuen7k 26 12 solid solid JJ cord-346964-9afuen7k 26 13 organ organ NN cord-346964-9afuen7k 26 14 transplantation transplantation NN cord-346964-9afuen7k 26 15 . . . cord-346964-9afuen7k 27 1 Intestinal intestinal JJ cord-346964-9afuen7k 27 2 lymphangiectasia lymphangiectasia NNP cord-346964-9afuen7k 27 3 Intestinal intestinal JJ cord-346964-9afuen7k 27 4 lymphangiectasia lymphangiectasia NNP cord-346964-9afuen7k 27 5 is be VBZ cord-346964-9afuen7k 27 6 defined define VBN cord-346964-9afuen7k 27 7 as as IN cord-346964-9afuen7k 27 8 the the DT cord-346964-9afuen7k 27 9 presence presence NN cord-346964-9afuen7k 27 10 of of IN cord-346964-9afuen7k 27 11 dilated dilated JJ cord-346964-9afuen7k 27 12 lymphatics lymphatic NNS cord-346964-9afuen7k 27 13 within within IN cord-346964-9afuen7k 27 14 the the DT cord-346964-9afuen7k 27 15 intestinal intestinal JJ cord-346964-9afuen7k 27 16 mucosa mucosa NN cord-346964-9afuen7k 27 17 . . . cord-346964-9afuen7k 28 1 It -PRON- PRP cord-346964-9afuen7k 28 2 can can MD cord-346964-9afuen7k 28 3 be be VB cord-346964-9afuen7k 28 4 either either CC cord-346964-9afuen7k 28 5 primary primary JJ cord-346964-9afuen7k 28 6 due due IN cord-346964-9afuen7k 28 7 to to IN cord-346964-9afuen7k 28 8 a a DT cord-346964-9afuen7k 28 9 structural structural JJ cord-346964-9afuen7k 28 10 abnormality abnormality NN cord-346964-9afuen7k 28 11 of of IN cord-346964-9afuen7k 28 12 the the DT cord-346964-9afuen7k 28 13 lymphatic lymphatic JJ cord-346964-9afuen7k 28 14 system system NN cord-346964-9afuen7k 28 15 or or CC cord-346964-9afuen7k 28 16 secondary secondary JJ cord-346964-9afuen7k 28 17 due due IN cord-346964-9afuen7k 28 18 to to IN cord-346964-9afuen7k 28 19 a a DT cord-346964-9afuen7k 28 20 local local JJ cord-346964-9afuen7k 28 21 neoplastic neoplastic JJ cord-346964-9afuen7k 28 22 or or CC cord-346964-9afuen7k 28 23 inflammatory inflammatory JJ cord-346964-9afuen7k 28 24 condition condition NN cord-346964-9afuen7k 28 25 causing cause VBG cord-346964-9afuen7k 28 26 lymphatic lymphatic JJ cord-346964-9afuen7k 28 27 obstruction obstruction NN cord-346964-9afuen7k 28 28 . . . cord-346964-9afuen7k 29 1 Intraepithelial intraepithelial JJ cord-346964-9afuen7k 29 2 lymphocyte lymphocyte NN cord-346964-9afuen7k 29 3 T t NN cord-346964-9afuen7k 29 4 cell cell NN cord-346964-9afuen7k 29 5 residing reside VBG cord-346964-9afuen7k 29 6 in in IN cord-346964-9afuen7k 29 7 the the DT cord-346964-9afuen7k 29 8 surface surface NN cord-346964-9afuen7k 29 9 epithelium epithelium NN cord-346964-9afuen7k 29 10 bearing bear VBG cord-346964-9afuen7k 29 11 T t NN cord-346964-9afuen7k 29 12 - - HYPH cord-346964-9afuen7k 29 13 cell cell NN cord-346964-9afuen7k 29 14 receptors receptor NNS cord-346964-9afuen7k 29 15 . . . cord-346964-9afuen7k 30 1 The the DT cord-346964-9afuen7k 30 2 majority majority NN cord-346964-9afuen7k 30 3 of of IN cord-346964-9afuen7k 30 4 IELs iel NNS cord-346964-9afuen7k 30 5 are be VBP cord-346964-9afuen7k 30 6 T T NNP cord-346964-9afuen7k 30 7 cells cell NNS cord-346964-9afuen7k 30 8 , , , cord-346964-9afuen7k 30 9 which which WDT cord-346964-9afuen7k 30 10 are be VBP cord-346964-9afuen7k 30 11 mostly mostly RB cord-346964-9afuen7k 30 12 cytotoxic cytotoxic JJ cord-346964-9afuen7k 30 13 T t NN cord-346964-9afuen7k 30 14 cells cell NNS cord-346964-9afuen7k 30 15 expressing express VBG cord-346964-9afuen7k 30 16 ab ab NNP cord-346964-9afuen7k 30 17 TCR TCR NNP cord-346964-9afuen7k 30 18 on on IN cord-346964-9afuen7k 30 19 their -PRON- PRP$ cord-346964-9afuen7k 30 20 surface surface NN cord-346964-9afuen7k 30 21 . . . cord-346964-9afuen7k 31 1 The the DT cord-346964-9afuen7k 31 2 population population NN cord-346964-9afuen7k 31 3 specifically specifically RB cord-346964-9afuen7k 31 4 expanded expand VBD cord-346964-9afuen7k 31 5 in in IN cord-346964-9afuen7k 31 6 GSE GSE NNP cord-346964-9afuen7k 31 7 is be VBZ cord-346964-9afuen7k 31 8 the the DT cord-346964-9afuen7k 31 9 CD3 CD3 NNP cord-346964-9afuen7k 31 10 þ þ NNP cord-346964-9afuen7k 31 11 / / SYM cord-346964-9afuen7k 31 12 CD4 CD4 NNP cord-346964-9afuen7k 31 13 À À NNP cord-346964-9afuen7k 31 14 / / SYM cord-346964-9afuen7k 31 15 CD8 CD8 NNP cord-346964-9afuen7k 31 16 À À NNP cord-346964-9afuen7k 31 17 , , , cord-346964-9afuen7k 31 18 gd gd NNP cord-346964-9afuen7k 31 19 TCR TCR NNP cord-346964-9afuen7k 31 20 - - HYPH cord-346964-9afuen7k 31 21 bearing bear VBG cord-346964-9afuen7k 31 22 IELs iel NNS cord-346964-9afuen7k 31 23 , , , cord-346964-9afuen7k 31 24 which which WDT cord-346964-9afuen7k 31 25 is be VBZ cord-346964-9afuen7k 31 26 only only RB cord-346964-9afuen7k 31 27 5 5 CD cord-346964-9afuen7k 31 28 % % NN cord-346964-9afuen7k 31 29 of of IN cord-346964-9afuen7k 31 30 the the DT cord-346964-9afuen7k 31 31 total total NN cord-346964-9afuen7k 31 32 in in IN cord-346964-9afuen7k 31 33 normal normal JJ cord-346964-9afuen7k 31 34 mucosa mucosa NN cord-346964-9afuen7k 31 35 . . . cord-346964-9afuen7k 32 1 Intraepithelial intraepithelial JJ cord-346964-9afuen7k 32 2 lymphocytosis lymphocytosis NN cord-346964-9afuen7k 32 3 Less Less JJR cord-346964-9afuen7k 32 4 than than IN cord-346964-9afuen7k 32 5 20 20 CD cord-346964-9afuen7k 32 6 intraepithelial intraepithelial JJ cord-346964-9afuen7k 32 7 lymphocytes/100 lymphocytes/100 NNP cord-346964-9afuen7k 32 8 enterocytes enterocytes NNP cord-346964-9afuen7k 32 9 . . . cord-346964-9afuen7k 33 1 Characteristic characteristic JJ cord-346964-9afuen7k 33 2 finding finding NN cord-346964-9afuen7k 33 3 in in IN cord-346964-9afuen7k 33 4 celiac celiac JJ cord-346964-9afuen7k 33 5 disease disease NN cord-346964-9afuen7k 33 6 but but CC cord-346964-9afuen7k 33 7 may may MD cord-346964-9afuen7k 33 8 also also RB cord-346964-9afuen7k 33 9 be be VB cord-346964-9afuen7k 33 10 found find VBN cord-346964-9afuen7k 33 11 in in IN cord-346964-9afuen7k 33 12 a a DT cord-346964-9afuen7k 33 13 variety variety NN cord-346964-9afuen7k 33 14 of of IN cord-346964-9afuen7k 33 15 intestinal intestinal JJ cord-346964-9afuen7k 33 16 disorders disorder NNS cord-346964-9afuen7k 33 17 causing cause VBG cord-346964-9afuen7k 33 18 malabsorption malabsorption NN cord-346964-9afuen7k 33 19 . . . cord-346964-9afuen7k 34 1 Malabsorption malabsorption NN cord-346964-9afuen7k 34 2 Malabsorption malabsorption NN cord-346964-9afuen7k 34 3 syndrome syndrome NN cord-346964-9afuen7k 34 4 refers refer VBZ cord-346964-9afuen7k 34 5 to to IN cord-346964-9afuen7k 34 6 the the DT cord-346964-9afuen7k 34 7 clinical clinical JJ cord-346964-9afuen7k 34 8 picture picture NN cord-346964-9afuen7k 34 9 comprising comprise VBG cord-346964-9afuen7k 34 10 diarrhea diarrhea NN cord-346964-9afuen7k 34 11 , , , cord-346964-9afuen7k 34 12 steatorrhea steatorrhea NN cord-346964-9afuen7k 34 13 , , , cord-346964-9afuen7k 34 14 malnutrition malnutrition NN cord-346964-9afuen7k 34 15 , , , cord-346964-9afuen7k 34 16 weight weight NN cord-346964-9afuen7k 34 17 loss loss NN cord-346964-9afuen7k 34 18 , , , cord-346964-9afuen7k 34 19 abdominal abdominal JJ cord-346964-9afuen7k 34 20 pain pain NN cord-346964-9afuen7k 34 21 , , , cord-346964-9afuen7k 34 22 and and CC cord-346964-9afuen7k 34 23 anemia anemia NN cord-346964-9afuen7k 34 24 due due IN cord-346964-9afuen7k 34 25 to to IN cord-346964-9afuen7k 34 26 maldigestion maldigestion NN cord-346964-9afuen7k 34 27 , , , cord-346964-9afuen7k 34 28 mucosal mucosal JJ cord-346964-9afuen7k 34 29 / / SYM cord-346964-9afuen7k 34 30 mural mural NN cord-346964-9afuen7k 34 31 problems problem NNS cord-346964-9afuen7k 34 32 , , , cord-346964-9afuen7k 34 33 or or CC cord-346964-9afuen7k 34 34 infections infection NNS cord-346964-9afuen7k 34 35 . . . cord-346964-9afuen7k 35 1 Microvillus Microvillus NNP cord-346964-9afuen7k 35 2 inclusion inclusion NN cord-346964-9afuen7k 35 3 disease disease NN cord-346964-9afuen7k 35 4 ( ( -LRB- cord-346964-9afuen7k 35 5 MVID MVID NNP cord-346964-9afuen7k 35 6 ) ) -RRB- cord-346964-9afuen7k 35 7 MVID MVID NNP cord-346964-9afuen7k 35 8 is be VBZ cord-346964-9afuen7k 35 9 an an DT cord-346964-9afuen7k 35 10 uncommon uncommon JJ cord-346964-9afuen7k 35 11 congenital congenital JJ cord-346964-9afuen7k 35 12 enteropathy enteropathy NNS cord-346964-9afuen7k 35 13 characterized characterize VBN cord-346964-9afuen7k 35 14 by by IN cord-346964-9afuen7k 35 15 severe severe JJ cord-346964-9afuen7k 35 16 , , , cord-346964-9afuen7k 35 17 intractable intractable JJ cord-346964-9afuen7k 35 18 diarrhea diarrhea NN cord-346964-9afuen7k 35 19 within within IN cord-346964-9afuen7k 35 20 the the DT cord-346964-9afuen7k 35 21 first first JJ cord-346964-9afuen7k 35 22 week week NN cord-346964-9afuen7k 35 23 of of IN cord-346964-9afuen7k 35 24 life life NN cord-346964-9afuen7k 35 25 due due JJ cord-346964-9afuen7k 35 26 to to IN cord-346964-9afuen7k 35 27 defective defective JJ cord-346964-9afuen7k 35 28 MYO5B myo5b CD cord-346964-9afuen7k 35 29 gene gene NN cord-346964-9afuen7k 35 30 located locate VBN cord-346964-9afuen7k 35 31 on on IN cord-346964-9afuen7k 35 32 18q21 18q21 CD cord-346964-9afuen7k 35 33 encoding encoding NN cord-346964-9afuen7k 35 34 myosin myosin NN cord-346964-9afuen7k 35 35 Vb Vb NNP cord-346964-9afuen7k 35 36 that that WDT cord-346964-9afuen7k 35 37 regulates regulate VBZ cord-346964-9afuen7k 35 38 distribution distribution NN cord-346964-9afuen7k 35 39 of of IN cord-346964-9afuen7k 35 40 endosomes endosome NNS cord-346964-9afuen7k 35 41 . . . cord-346964-9afuen7k 36 1 It -PRON- PRP cord-346964-9afuen7k 36 2 is be VBZ cord-346964-9afuen7k 36 3 characterized characterize VBN cord-346964-9afuen7k 36 4 by by IN cord-346964-9afuen7k 36 5 loss loss NN cord-346964-9afuen7k 36 6 of of IN cord-346964-9afuen7k 36 7 microvilli microvilli NN cord-346964-9afuen7k 36 8 and and CC cord-346964-9afuen7k 36 9 numerous numerous JJ cord-346964-9afuen7k 36 10 microvillus microvillus JJ cord-346964-9afuen7k 36 11 inclusions inclusion NNS cord-346964-9afuen7k 36 12 in in IN cord-346964-9afuen7k 36 13 the the DT cord-346964-9afuen7k 36 14 apical apical JJ cord-346964-9afuen7k 36 15 cytoplasm cytoplasm NN cord-346964-9afuen7k 36 16 of of IN cord-346964-9afuen7k 36 17 the the DT cord-346964-9afuen7k 36 18 enterocytes enterocyte NNS cord-346964-9afuen7k 36 19 . . . cord-346964-9afuen7k 37 1 Neonatal neonatal JJ cord-346964-9afuen7k 37 2 enteropathy enteropathy NNS cord-346964-9afuen7k 37 3 Severe severe JJ cord-346964-9afuen7k 37 4 intractable intractable JJ cord-346964-9afuen7k 37 5 chronic chronic NN cord-346964-9afuen7k 37 6 ( ( -LRB- cord-346964-9afuen7k 37 7 > > NFP cord-346964-9afuen7k 37 8 2 2 CD cord-346964-9afuen7k 37 9 - - SYM cord-346964-9afuen7k 37 10 3 3 CD cord-346964-9afuen7k 37 11 weeks week NNS cord-346964-9afuen7k 37 12 ) ) -RRB- cord-346964-9afuen7k 37 13 diarrhea diarrhea NN cord-346964-9afuen7k 37 14 starting start VBG cord-346964-9afuen7k 37 15 immediately immediately RB cord-346964-9afuen7k 37 16 after after IN cord-346964-9afuen7k 37 17 birth birth NN cord-346964-9afuen7k 37 18 and and CC cord-346964-9afuen7k 37 19 resulting result VBG cord-346964-9afuen7k 37 20 in in IN cord-346964-9afuen7k 37 21 failure failure NN cord-346964-9afuen7k 37 22 to to TO cord-346964-9afuen7k 37 23 thrive thrive VB cord-346964-9afuen7k 37 24 of of IN cord-346964-9afuen7k 37 25 the the DT cord-346964-9afuen7k 37 26 infant infant NN cord-346964-9afuen7k 37 27 . . . cord-346964-9afuen7k 38 1 Peptic peptic JJ cord-346964-9afuen7k 38 2 duodenal duodenal JJ cord-346964-9afuen7k 38 3 disease disease NN cord-346964-9afuen7k 39 1 This this DT cord-346964-9afuen7k 39 2 represents represent VBZ cord-346964-9afuen7k 39 3 a a DT cord-346964-9afuen7k 39 4 continuum continuum NN cord-346964-9afuen7k 39 5 of of IN cord-346964-9afuen7k 39 6 the the DT cord-346964-9afuen7k 39 7 same same JJ cord-346964-9afuen7k 39 8 disease disease NN cord-346964-9afuen7k 39 9 process process NN cord-346964-9afuen7k 39 10 of of IN cord-346964-9afuen7k 39 11 acute acute JJ cord-346964-9afuen7k 39 12 and and CC cord-346964-9afuen7k 39 13 chronic chronic JJ cord-346964-9afuen7k 39 14 inflammation inflammation NN cord-346964-9afuen7k 39 15 of of IN cord-346964-9afuen7k 39 16 the the DT cord-346964-9afuen7k 39 17 duodenal duodenal JJ cord-346964-9afuen7k 39 18 mucosa mucosa NN cord-346964-9afuen7k 39 19 resulting result VBG cord-346964-9afuen7k 39 20 from from IN cord-346964-9afuen7k 39 21 the the DT cord-346964-9afuen7k 39 22 toxic toxic JJ cord-346964-9afuen7k 39 23 effects effect NNS cord-346964-9afuen7k 39 24 of of IN cord-346964-9afuen7k 39 25 excess excess JJ cord-346964-9afuen7k 39 26 gastric gastric JJ cord-346964-9afuen7k 39 27 acid acid NN cord-346964-9afuen7k 39 28 . . . cord-346964-9afuen7k 40 1 Chronic chronic JJ cord-346964-9afuen7k 40 2 H. H. NNP cord-346964-9afuen7k 40 3 pylori pylori NN cord-346964-9afuen7k 40 4 infection infection NN cord-346964-9afuen7k 40 5 is be VBZ cord-346964-9afuen7k 40 6 highly highly RB cord-346964-9afuen7k 40 7 associated associate VBN cord-346964-9afuen7k 40 8 with with IN cord-346964-9afuen7k 40 9 peptic peptic JJ cord-346964-9afuen7k 40 10 disease disease NN cord-346964-9afuen7k 40 11 of of IN cord-346964-9afuen7k 40 12 the the DT cord-346964-9afuen7k 40 13 duodenum duodenum NN cord-346964-9afuen7k 40 14 in in IN cord-346964-9afuen7k 40 15 more more JJR cord-346964-9afuen7k 40 16 than than IN cord-346964-9afuen7k 40 17 80 80 CD cord-346964-9afuen7k 40 18 % % NN cord-346964-9afuen7k 40 19 of of IN cord-346964-9afuen7k 40 20 the the DT cord-346964-9afuen7k 40 21 cases case NNS cord-346964-9afuen7k 40 22 . . . cord-346964-9afuen7k 41 1 Refractory refractory JJ cord-346964-9afuen7k 41 2 sprue sprue NN cord-346964-9afuen7k 41 3 Refractory refractory JJ cord-346964-9afuen7k 41 4 sprue sprue NN cord-346964-9afuen7k 41 5 is be VBZ cord-346964-9afuen7k 41 6 defined define VBN cord-346964-9afuen7k 41 7 as as IN cord-346964-9afuen7k 41 8 incomplete incomplete JJ cord-346964-9afuen7k 41 9 or or CC cord-346964-9afuen7k 41 10 no no DT cord-346964-9afuen7k 41 11 response response NN cord-346964-9afuen7k 41 12 to to IN cord-346964-9afuen7k 41 13 GFD GFD NNP cord-346964-9afuen7k 41 14 for for IN cord-346964-9afuen7k 41 15 at at RB cord-346964-9afuen7k 41 16 least least RBS cord-346964-9afuen7k 41 17 6 6 CD cord-346964-9afuen7k 41 18 months month NNS cord-346964-9afuen7k 41 19 . . . cord-346964-9afuen7k 42 1 It -PRON- PRP cord-346964-9afuen7k 42 2 can can MD cord-346964-9afuen7k 42 3 be be VB cord-346964-9afuen7k 42 4 either either CC cord-346964-9afuen7k 42 5 primary primary JJ cord-346964-9afuen7k 42 6 , , , cord-346964-9afuen7k 42 7 as as IN cord-346964-9afuen7k 42 8 lack lack NN cord-346964-9afuen7k 42 9 of of IN cord-346964-9afuen7k 42 10 initial initial JJ cord-346964-9afuen7k 42 11 response response NN cord-346964-9afuen7k 42 12 to to IN cord-346964-9afuen7k 42 13 diet diet NN cord-346964-9afuen7k 42 14 , , , cord-346964-9afuen7k 42 15 or or CC cord-346964-9afuen7k 42 16 secondary secondary JJ cord-346964-9afuen7k 42 17 , , , cord-346964-9afuen7k 42 18 as as IN cord-346964-9afuen7k 42 19 unresponsiveness unresponsiveness NN cord-346964-9afuen7k 42 20 to to IN cord-346964-9afuen7k 42 21 diet diet VB cord-346964-9afuen7k 42 22 in in IN cord-346964-9afuen7k 42 23 the the DT cord-346964-9afuen7k 42 24 form form NN cord-346964-9afuen7k 42 25 of of IN cord-346964-9afuen7k 42 26 a a DT cord-346964-9afuen7k 42 27 relapse relapse NN cord-346964-9afuen7k 42 28 . . . cord-346964-9afuen7k 43 1 Primary primary JJ cord-346964-9afuen7k 43 2 refractory refractory JJ cord-346964-9afuen7k 43 3 sprue sprue NN cord-346964-9afuen7k 43 4 can can MD cord-346964-9afuen7k 43 5 include include VB cord-346964-9afuen7k 43 6 many many JJ cord-346964-9afuen7k 43 7 different different JJ cord-346964-9afuen7k 43 8 pathological pathological JJ cord-346964-9afuen7k 43 9 conditions condition NNS cord-346964-9afuen7k 43 10 mimicking mimic VBG cord-346964-9afuen7k 43 11 CD cd NN cord-346964-9afuen7k 43 12 , , , cord-346964-9afuen7k 43 13 comprising comprise VBG cord-346964-9afuen7k 43 14 collagenous collagenous NNP cord-346964-9afuen7k 43 15 sprue sprue NNP cord-346964-9afuen7k 43 16 , , , cord-346964-9afuen7k 43 17 ulcerative ulcerative JJ cord-346964-9afuen7k 43 18 jejunitis jejunitis NN cord-346964-9afuen7k 43 19 , , , cord-346964-9afuen7k 43 20 lymphocytic lymphocytic JJ cord-346964-9afuen7k 43 21 colitis colitis NN cord-346964-9afuen7k 43 22 , , , cord-346964-9afuen7k 43 23 collagenous collagenous JJ cord-346964-9afuen7k 43 24 colitis colitis NN cord-346964-9afuen7k 43 25 , , , cord-346964-9afuen7k 43 26 and and CC cord-346964-9afuen7k 43 27 EITCL EITCL NNP cord-346964-9afuen7k 43 28 . . . cord-346964-9afuen7k 44 1 Small small JJ cord-346964-9afuen7k 44 2 intestinal intestinal JJ cord-346964-9afuen7k 44 3 bacterial bacterial JJ cord-346964-9afuen7k 44 4 overgrowth overgrowth NN cord-346964-9afuen7k 44 5 ( ( -LRB- cord-346964-9afuen7k 44 6 SIBO SIBO NNP cord-346964-9afuen7k 44 7 ) ) -RRB- cord-346964-9afuen7k 45 1 Stasis stasis NN cord-346964-9afuen7k 45 2 caused cause VBN cord-346964-9afuen7k 45 3 by by IN cord-346964-9afuen7k 45 4 motor motor NN cord-346964-9afuen7k 45 5 / / SYM cord-346964-9afuen7k 45 6 neural neural JJ cord-346964-9afuen7k 45 7 disorders disorder NNS cord-346964-9afuen7k 45 8 such such JJ cord-346964-9afuen7k 45 9 as as IN cord-346964-9afuen7k 45 10 diabetes diabetes NN cord-346964-9afuen7k 45 11 and and CC cord-346964-9afuen7k 45 12 scleroderma scleroderma NN cord-346964-9afuen7k 45 13 , , , cord-346964-9afuen7k 45 14 diverticula diverticula NN cord-346964-9afuen7k 45 15 , , , cord-346964-9afuen7k 45 16 and and CC cord-346964-9afuen7k 45 17 surgical surgical JJ cord-346964-9afuen7k 45 18 anastomoses anastomosis NNS cord-346964-9afuen7k 45 19 results result NNS cord-346964-9afuen7k 45 20 in in IN cord-346964-9afuen7k 45 21 abnormal abnormal JJ cord-346964-9afuen7k 45 22 proliferation proliferation NN cord-346964-9afuen7k 45 23 of of IN cord-346964-9afuen7k 45 24 facultative facultative JJ cord-346964-9afuen7k 45 25 aerobe aerobe NNS cord-346964-9afuen7k 45 26 bacteria bacteria NNS cord-346964-9afuen7k 45 27 normally normally RB cord-346964-9afuen7k 45 28 colonized colonize VBN cord-346964-9afuen7k 45 29 in in IN cord-346964-9afuen7k 45 30 the the DT cord-346964-9afuen7k 45 31 intestinal intestinal JJ cord-346964-9afuen7k 45 32 lumen lumen NN cord-346964-9afuen7k 45 33 . . . cord-346964-9afuen7k 46 1 Tissue tissue NN cord-346964-9afuen7k 46 2 transglutaminase transglutaminase NN cord-346964-9afuen7k 47 1 The the DT cord-346964-9afuen7k 47 2 enzyme enzyme NN cord-346964-9afuen7k 47 3 found find VBN cord-346964-9afuen7k 47 4 in in IN cord-346964-9afuen7k 47 5 the the DT cord-346964-9afuen7k 47 6 lamina lamina JJ cord-346964-9afuen7k 47 7 propria propria NN cord-346964-9afuen7k 47 8 beneath beneath IN cord-346964-9afuen7k 47 9 the the DT cord-346964-9afuen7k 47 10 surface surface NN cord-346964-9afuen7k 47 11 epithelium epithelium NN cord-346964-9afuen7k 47 12 of of IN cord-346964-9afuen7k 47 13 small small JJ cord-346964-9afuen7k 47 14 intestinal intestinal JJ cord-346964-9afuen7k 47 15 mucosa mucosa NN cord-346964-9afuen7k 47 16 that that WDT cord-346964-9afuen7k 47 17 removes remove VBZ cord-346964-9afuen7k 47 18 an an DT cord-346964-9afuen7k 47 19 amino amino NN cord-346964-9afuen7k 47 20 group group NN cord-346964-9afuen7k 47 21 from from IN cord-346964-9afuen7k 47 22 gliadin gliadin NN cord-346964-9afuen7k 47 23 ( ( -LRB- cord-346964-9afuen7k 47 24 deamidation deamidation NN cord-346964-9afuen7k 47 25 ) ) -RRB- cord-346964-9afuen7k 47 26 and and CC cord-346964-9afuen7k 47 27 adds add VBZ cord-346964-9afuen7k 47 28 the the DT cord-346964-9afuen7k 47 29 remainder remainder NN cord-346964-9afuen7k 47 30 of of IN cord-346964-9afuen7k 47 31 the the DT cord-346964-9afuen7k 47 32 peptide peptide NN cord-346964-9afuen7k 47 33 to to IN cord-346964-9afuen7k 47 34 the the DT cord-346964-9afuen7k 47 35 existing exist VBG cord-346964-9afuen7k 47 36 protein protein NN cord-346964-9afuen7k 47 37 . . . cord-346964-9afuen7k 48 1 Tropical tropical JJ cord-346964-9afuen7k 48 2 ( ( -LRB- cord-346964-9afuen7k 48 3 postinfectious postinfectious NNP cord-346964-9afuen7k 48 4 ) ) -RRB- cord-346964-9afuen7k 48 5 sprue sprue NN cord-346964-9afuen7k 49 1 This this DT cord-346964-9afuen7k 49 2 is be VBZ cord-346964-9afuen7k 49 3 a a DT cord-346964-9afuen7k 49 4 rare rare JJ cord-346964-9afuen7k 49 5 disorder disorder NN cord-346964-9afuen7k 49 6 of of IN cord-346964-9afuen7k 49 7 unknown unknown JJ cord-346964-9afuen7k 49 8 etiology etiology NN cord-346964-9afuen7k 49 9 , , , cord-346964-9afuen7k 49 10 mainly mainly RB cord-346964-9afuen7k 49 11 occurring occur VBG cord-346964-9afuen7k 49 12 among among IN cord-346964-9afuen7k 49 13 residents resident NNS cord-346964-9afuen7k 49 14 or or CC cord-346964-9afuen7k 49 15 visitors visitor NNS cord-346964-9afuen7k 49 16 to to IN cord-346964-9afuen7k 49 17 the the DT cord-346964-9afuen7k 49 18 tropical tropical JJ cord-346964-9afuen7k 49 19 countries country NNS cord-346964-9afuen7k 49 20 . . . cord-346964-9afuen7k 50 1 Malabsorption malabsorption NN cord-346964-9afuen7k 50 2 is be VBZ cord-346964-9afuen7k 50 3 usually usually RB cord-346964-9afuen7k 50 4 initiated initiate VBN cord-346964-9afuen7k 50 5 by by IN cord-346964-9afuen7k 50 6 an an DT cord-346964-9afuen7k 50 7 infection infection NN cord-346964-9afuen7k 50 8 followed follow VBN cord-346964-9afuen7k 50 9 by by IN cord-346964-9afuen7k 50 10 colonization colonization NN cord-346964-9afuen7k 50 11 of of IN cord-346964-9afuen7k 50 12 the the DT cord-346964-9afuen7k 50 13 small small JJ cord-346964-9afuen7k 50 14 bowel bowel NN cord-346964-9afuen7k 50 15 by by IN cord-346964-9afuen7k 50 16 enterotoxigenic enterotoxigenic JJ cord-346964-9afuen7k 50 17 bacteria bacteria NNS cord-346964-9afuen7k 50 18 . . . cord-346964-9afuen7k 51 1 Tufting tufte VBG cord-346964-9afuen7k 51 2 enteropathy enteropathy NNP cord-346964-9afuen7k 51 3 ( ( -LRB- cord-346964-9afuen7k 51 4 TE TE NNP cord-346964-9afuen7k 51 5 ) ) -RRB- cord-346964-9afuen7k 51 6 TE TE NNP cord-346964-9afuen7k 51 7 causes cause VBZ cord-346964-9afuen7k 51 8 severe severe JJ cord-346964-9afuen7k 51 9 diarrhea diarrhea NN cord-346964-9afuen7k 51 10 in in IN cord-346964-9afuen7k 51 11 the the DT cord-346964-9afuen7k 51 12 first first JJ cord-346964-9afuen7k 51 13 week week NN cord-346964-9afuen7k 51 14 of of IN cord-346964-9afuen7k 51 15 life life NN cord-346964-9afuen7k 51 16 together together RB cord-346964-9afuen7k 51 17 with with IN cord-346964-9afuen7k 51 18 various various JJ cord-346964-9afuen7k 51 19 dysmorphic dysmorphic JJ cord-346964-9afuen7k 51 20 features feature NNS cord-346964-9afuen7k 51 21 including include VBG cord-346964-9afuen7k 51 22 choanal choanal JJ cord-346964-9afuen7k 51 23 atresia atresia NN cord-346964-9afuen7k 51 24 and and CC cord-346964-9afuen7k 51 25 esophageal esophageal JJ cord-346964-9afuen7k 51 26 / / SYM cord-346964-9afuen7k 51 27 rectal rectal JJ cord-346964-9afuen7k 51 28 atresia atresia NN cord-346964-9afuen7k 51 29 in in IN cord-346964-9afuen7k 51 30 some some DT cord-346964-9afuen7k 51 31 of of IN cord-346964-9afuen7k 51 32 the the DT cord-346964-9afuen7k 51 33 affected affect VBN cord-346964-9afuen7k 51 34 infants infant NNS cord-346964-9afuen7k 51 35 . . . cord-346964-9afuen7k 52 1 EpCAM EpCAM NNP cord-346964-9afuen7k 52 2 mutations mutation NNS cord-346964-9afuen7k 52 3 on on IN cord-346964-9afuen7k 52 4 chromosome chromosome NN cord-346964-9afuen7k 52 5 2p21 2p21 CD cord-346964-9afuen7k 52 6 have have VBP cord-346964-9afuen7k 52 7 recently recently RB cord-346964-9afuen7k 52 8 been be VBN cord-346964-9afuen7k 52 9 suggested suggest VBN cord-346964-9afuen7k 52 10 as as IN cord-346964-9afuen7k 52 11 the the DT cord-346964-9afuen7k 52 12 responsible responsible JJ cord-346964-9afuen7k 52 13 genetic genetic JJ cord-346964-9afuen7k 52 14 abnormalities abnormality NNS cord-346964-9afuen7k 52 15 . . . cord-346964-9afuen7k 53 1 It -PRON- PRP cord-346964-9afuen7k 53 2 is be VBZ cord-346964-9afuen7k 53 3 characterized characterize VBN cord-346964-9afuen7k 53 4 by by IN cord-346964-9afuen7k 53 5 epithelial epithelial JJ cord-346964-9afuen7k 53 6 tufts tuft NNS cord-346964-9afuen7k 53 7 or or CC cord-346964-9afuen7k 53 8 buds bud NNS cord-346964-9afuen7k 53 9 along along IN cord-346964-9afuen7k 53 10 the the DT cord-346964-9afuen7k 53 11 luminal luminal JJ cord-346964-9afuen7k 53 12 aspect aspect NN cord-346964-9afuen7k 53 13 of of IN cord-346964-9afuen7k 53 14 the the DT cord-346964-9afuen7k 53 15 enterocytes enterocyte NNS cord-346964-9afuen7k 53 16 . . . cord-346964-9afuen7k 53 17 _SP cord-346964-9afuen7k 54 1 Small small JJ cord-346964-9afuen7k 54 2 intestine intestine NN cord-346964-9afuen7k 54 3 is be VBZ cord-346964-9afuen7k 54 4 the the DT cord-346964-9afuen7k 54 5 part part NN cord-346964-9afuen7k 54 6 of of IN cord-346964-9afuen7k 54 7 the the DT cord-346964-9afuen7k 54 8 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 54 9 tract tract NN cord-346964-9afuen7k 54 10 where where WRB cord-346964-9afuen7k 54 11 much much JJ cord-346964-9afuen7k 54 12 of of IN cord-346964-9afuen7k 54 13 the the DT cord-346964-9afuen7k 54 14 absorption absorption NN cord-346964-9afuen7k 54 15 takes take VBZ cord-346964-9afuen7k 54 16 place place NN cord-346964-9afuen7k 54 17 due due IN cord-346964-9afuen7k 54 18 to to IN cord-346964-9afuen7k 54 19 its -PRON- PRP$ cord-346964-9afuen7k 54 20 large large JJ cord-346964-9afuen7k 54 21 surface surface NN cord-346964-9afuen7k 54 22 area area NN cord-346964-9afuen7k 54 23 provided provide VBN cord-346964-9afuen7k 54 24 by by IN cord-346964-9afuen7k 54 25 the the DT cord-346964-9afuen7k 54 26 numerous numerous JJ cord-346964-9afuen7k 54 27 microvilli microvilli NN cord-346964-9afuen7k 54 28 covering cover VBG cord-346964-9afuen7k 54 29 intestinal intestinal JJ cord-346964-9afuen7k 54 30 villi villi NN cord-346964-9afuen7k 54 31 and and CC cord-346964-9afuen7k 54 32 the the DT cord-346964-9afuen7k 54 33 digestive digestive JJ cord-346964-9afuen7k 54 34 enzymes enzyme NNS cord-346964-9afuen7k 54 35 on on IN cord-346964-9afuen7k 54 36 its -PRON- PRP$ cord-346964-9afuen7k 54 37 surface surface NN cord-346964-9afuen7k 54 38 actively actively RB cord-346964-9afuen7k 54 39 secreted secrete VBD cord-346964-9afuen7k 54 40 to to TO cord-346964-9afuen7k 54 41 optimize optimize VB cord-346964-9afuen7k 54 42 uptake uptake NN cord-346964-9afuen7k 54 43 of of IN cord-346964-9afuen7k 54 44 dietary dietary JJ cord-346964-9afuen7k 54 45 substances substance NNS cord-346964-9afuen7k 54 46 . . . cord-346964-9afuen7k 55 1 Adequate adequate JJ cord-346964-9afuen7k 55 2 absorption absorption NN cord-346964-9afuen7k 55 3 takes take VBZ cord-346964-9afuen7k 55 4 place place NN cord-346964-9afuen7k 55 5 when when WRB cord-346964-9afuen7k 55 6 there there EX cord-346964-9afuen7k 55 7 are be VBP cord-346964-9afuen7k 55 8 mechanically mechanically RB cord-346964-9afuen7k 55 9 intact intact JJ cord-346964-9afuen7k 55 10 digestive digestive JJ cord-346964-9afuen7k 55 11 organs organ NNS cord-346964-9afuen7k 55 12 to to TO cord-346964-9afuen7k 55 13 produce produce VB cord-346964-9afuen7k 55 14 the the DT cord-346964-9afuen7k 55 15 necessary necessary JJ cord-346964-9afuen7k 55 16 enzymes enzyme NNS cord-346964-9afuen7k 55 17 as as RB cord-346964-9afuen7k 55 18 well well RB cord-346964-9afuen7k 55 19 as as IN cord-346964-9afuen7k 55 20 an an DT cord-346964-9afuen7k 55 21 adequate adequate JJ cord-346964-9afuen7k 55 22 blood blood NN cord-346964-9afuen7k 55 23 supply supply NN cord-346964-9afuen7k 55 24 , , , cord-346964-9afuen7k 55 25 motility motility NN cord-346964-9afuen7k 55 26 , , , cord-346964-9afuen7k 55 27 and and CC cord-346964-9afuen7k 55 28 microflora microflora NN cord-346964-9afuen7k 55 29 . . . cord-346964-9afuen7k 56 1 Malabsorption malabsorption NN cord-346964-9afuen7k 56 2 develops develop VBZ cord-346964-9afuen7k 56 3 when when WRB cord-346964-9afuen7k 56 4 malfunction malfunction NN cord-346964-9afuen7k 56 5 in in IN cord-346964-9afuen7k 56 6 any any DT cord-346964-9afuen7k 56 7 of of IN cord-346964-9afuen7k 56 8 these these DT cord-346964-9afuen7k 56 9 components component NNS cord-346964-9afuen7k 56 10 leads lead VBZ cord-346964-9afuen7k 56 11 to to IN cord-346964-9afuen7k 56 12 failure failure NN cord-346964-9afuen7k 56 13 of of IN cord-346964-9afuen7k 56 14 absorption absorption NN cord-346964-9afuen7k 56 15 of of IN cord-346964-9afuen7k 56 16 nutrients nutrient NNS cord-346964-9afuen7k 56 17 resulting result VBG cord-346964-9afuen7k 56 18 from from IN cord-346964-9afuen7k 56 19 a a DT cord-346964-9afuen7k 56 20 wide wide JJ cord-346964-9afuen7k 56 21 variety variety NN cord-346964-9afuen7k 56 22 of of IN cord-346964-9afuen7k 56 23 causes cause NNS cord-346964-9afuen7k 56 24 ( ( -LRB- cord-346964-9afuen7k 56 25 Figure figure NN cord-346964-9afuen7k 56 26 1 1 CD cord-346964-9afuen7k 56 27 and and CC cord-346964-9afuen7k 56 28 Table Table NNP cord-346964-9afuen7k 56 29 1 1 CD cord-346964-9afuen7k 56 30 ) ) -RRB- cord-346964-9afuen7k 56 31 , , , cord-346964-9afuen7k 56 32 the the DT cord-346964-9afuen7k 56 33 mechanisms mechanism NNS cord-346964-9afuen7k 56 34 of of IN cord-346964-9afuen7k 56 35 which which WDT cord-346964-9afuen7k 56 36 can can MD cord-346964-9afuen7k 56 37 be be VB cord-346964-9afuen7k 56 38 classified classify VBN cord-346964-9afuen7k 56 39 into into IN cord-346964-9afuen7k 56 40 three three CD cord-346964-9afuen7k 56 41 groups group NNS cord-346964-9afuen7k 56 42 : : : cord-346964-9afuen7k 56 43 ( ( -LRB- cord-346964-9afuen7k 56 44 i i NN cord-346964-9afuen7k 56 45 ) ) -RRB- cord-346964-9afuen7k 56 46 maldigestion maldigestion NNP cord-346964-9afuen7k 56 47 , , , cord-346964-9afuen7k 56 48 which which WDT cord-346964-9afuen7k 56 49 is be VBZ cord-346964-9afuen7k 56 50 related relate VBN cord-346964-9afuen7k 56 51 to to IN cord-346964-9afuen7k 56 52 mixing mix VBG cord-346964-9afuen7k 56 53 and and CC cord-346964-9afuen7k 56 54 digestive digestive JJ cord-346964-9afuen7k 56 55 mediators mediator NNS cord-346964-9afuen7k 56 56 ; ; , cord-346964-9afuen7k 56 57 ( ( -LRB- cord-346964-9afuen7k 56 58 ii ii NN cord-346964-9afuen7k 56 59 ) ) -RRB- cord-346964-9afuen7k 57 1 mucosal mucosal JJ cord-346964-9afuen7k 57 2 or or CC cord-346964-9afuen7k 57 3 mural mural NN cord-346964-9afuen7k 57 4 causes cause NNS cord-346964-9afuen7k 57 5 including include VBG cord-346964-9afuen7k 57 6 celiac celiac JJ cord-346964-9afuen7k 57 7 disease disease NN cord-346964-9afuen7k 57 8 ( ( -LRB- cord-346964-9afuen7k 57 9 CD CD NNP cord-346964-9afuen7k 57 10 ) ) -RRB- cord-346964-9afuen7k 57 11 ; ; : cord-346964-9afuen7k 57 12 and and CC cord-346964-9afuen7k 57 13 ( ( -LRB- cord-346964-9afuen7k 57 14 iii iii NN cord-346964-9afuen7k 57 15 ) ) -RRB- cord-346964-9afuen7k 57 16 microbial microbial JJ cord-346964-9afuen7k 57 17 causes cause NNS cord-346964-9afuen7k 57 18 ( ( -LRB- cord-346964-9afuen7k 57 19 Table table NN cord-346964-9afuen7k 57 20 2 2 CD cord-346964-9afuen7k 57 21 ) ) -RRB- cord-346964-9afuen7k 57 22 . . . cord-346964-9afuen7k 58 1 Physiologically physiologically RB cord-346964-9afuen7k 58 2 , , , cord-346964-9afuen7k 58 3 there there EX cord-346964-9afuen7k 58 4 are be VBP cord-346964-9afuen7k 58 5 three three CD cord-346964-9afuen7k 58 6 phases phase NNS cord-346964-9afuen7k 58 7 of of IN cord-346964-9afuen7k 58 8 absorption absorption NN cord-346964-9afuen7k 58 9 , , , cord-346964-9afuen7k 58 10 luminal luminal JJ cord-346964-9afuen7k 58 11 digestion digestion NN cord-346964-9afuen7k 58 12 , , , cord-346964-9afuen7k 58 13 mucosal mucosal JJ cord-346964-9afuen7k 58 14 digestion digestion NN cord-346964-9afuen7k 58 15 , , , cord-346964-9afuen7k 58 16 and and CC cord-346964-9afuen7k 58 17 mucosal mucosal JJ cord-346964-9afuen7k 58 18 absorption absorption NN cord-346964-9afuen7k 58 19 . . . cord-346964-9afuen7k 59 1 The the DT cord-346964-9afuen7k 59 2 luminal luminal JJ cord-346964-9afuen7k 59 3 phase phase NN cord-346964-9afuen7k 59 4 consists consist VBZ cord-346964-9afuen7k 59 5 of of IN cord-346964-9afuen7k 59 6 the the DT cord-346964-9afuen7k 59 7 breakdown breakdown NN cord-346964-9afuen7k 59 8 of of IN cord-346964-9afuen7k 59 9 proteins protein NNS cord-346964-9afuen7k 59 10 , , , cord-346964-9afuen7k 59 11 carbohydrates carbohydrate NNS cord-346964-9afuen7k 59 12 , , , cord-346964-9afuen7k 59 13 and and CC cord-346964-9afuen7k 59 14 fats fat NNS cord-346964-9afuen7k 59 15 by by IN cord-346964-9afuen7k 59 16 digestive digestive JJ cord-346964-9afuen7k 59 17 enzymes enzyme NNS cord-346964-9afuen7k 59 18 and and CC cord-346964-9afuen7k 59 19 bile bile NN cord-346964-9afuen7k 59 20 , , , cord-346964-9afuen7k 59 21 while while IN cord-346964-9afuen7k 59 22 mucosal mucosal JJ cord-346964-9afuen7k 59 23 phase phase NN cord-346964-9afuen7k 59 24 involves involve VBZ cord-346964-9afuen7k 59 25 hydrolysis hydrolysis NN cord-346964-9afuen7k 59 26 of of IN cord-346964-9afuen7k 59 27 carbohydrates carbohydrate NNS cord-346964-9afuen7k 59 28 and and CC cord-346964-9afuen7k 59 29 peptides peptide NNS cord-346964-9afuen7k 59 30 by by IN cord-346964-9afuen7k 59 31 enzymes enzyme NNS cord-346964-9afuen7k 59 32 of of IN cord-346964-9afuen7k 59 33 enterocyte enterocyte NNP cord-346964-9afuen7k 59 34 membrane membrane NN cord-346964-9afuen7k 59 35 ( ( -LRB- cord-346964-9afuen7k 59 36 disaccharidases disaccharidases NNP cord-346964-9afuen7k 59 37 and and CC cord-346964-9afuen7k 59 38 peptidases peptidases NNP cord-346964-9afuen7k 59 39 ) ) -RRB- cord-346964-9afuen7k 59 40 , , , cord-346964-9afuen7k 59 41 and and CC cord-346964-9afuen7k 59 42 absorption absorption NN cord-346964-9afuen7k 59 43 phase phase NN cord-346964-9afuen7k 59 44 comprises comprise VBZ cord-346964-9afuen7k 59 45 transepithelial transepithelial JJ cord-346964-9afuen7k 59 46 transport transport NN cord-346964-9afuen7k 59 47 of of IN cord-346964-9afuen7k 59 48 nutrients nutrient NNS cord-346964-9afuen7k 59 49 , , , cord-346964-9afuen7k 59 50 fluid fluid NN cord-346964-9afuen7k 59 51 , , , cord-346964-9afuen7k 59 52 and and CC cord-346964-9afuen7k 59 53 electrolytes electrolyte NNS cord-346964-9afuen7k 59 54 to to IN cord-346964-9afuen7k 59 55 the the DT cord-346964-9afuen7k 59 56 blood blood NN cord-346964-9afuen7k 59 57 vessels vessel NNS cord-346964-9afuen7k 59 58 through through IN cord-346964-9afuen7k 59 59 enterocytes enterocyte NNS cord-346964-9afuen7k 59 60 . . . cord-346964-9afuen7k 60 1 Malabsorption malabsorption NN cord-346964-9afuen7k 60 2 can can MD cord-346964-9afuen7k 60 3 , , , cord-346964-9afuen7k 60 4 therefore therefore RB cord-346964-9afuen7k 60 5 , , , cord-346964-9afuen7k 60 6 result result VB cord-346964-9afuen7k 60 7 from from IN cord-346964-9afuen7k 60 8 defects defect NNS cord-346964-9afuen7k 60 9 in in IN cord-346964-9afuen7k 60 10 either either DT cord-346964-9afuen7k 60 11 of of IN cord-346964-9afuen7k 60 12 these these DT cord-346964-9afuen7k 60 13 phases phase NNS cord-346964-9afuen7k 60 14 . . . cord-346964-9afuen7k 61 1 In in IN cord-346964-9afuen7k 61 2 the the DT cord-346964-9afuen7k 61 3 succeeding succeed VBG cord-346964-9afuen7k 61 4 text text NN cord-346964-9afuen7k 61 5 , , , cord-346964-9afuen7k 61 6 the the DT cord-346964-9afuen7k 61 7 mechanisms mechanism NNS cord-346964-9afuen7k 61 8 of of IN cord-346964-9afuen7k 61 9 malabsorption malabsorption NN cord-346964-9afuen7k 61 10 are be VBP cord-346964-9afuen7k 61 11 further further RB cord-346964-9afuen7k 61 12 discussed discuss VBN cord-346964-9afuen7k 61 13 for for IN cord-346964-9afuen7k 61 14 each each DT cord-346964-9afuen7k 61 15 of of IN cord-346964-9afuen7k 61 16 these these DT cord-346964-9afuen7k 61 17 phases phase NNS cord-346964-9afuen7k 61 18 : : : cord-346964-9afuen7k 62 1 1 1 LS cord-346964-9afuen7k 62 2 . . . cord-346964-9afuen7k 63 1 The the DT cord-346964-9afuen7k 63 2 luminal luminal JJ cord-346964-9afuen7k 63 3 phase phase NN cord-346964-9afuen7k 63 4 is be VBZ cord-346964-9afuen7k 63 5 where where WRB cord-346964-9afuen7k 63 6 dietary dietary JJ cord-346964-9afuen7k 63 7 fats fat NNS cord-346964-9afuen7k 63 8 , , , cord-346964-9afuen7k 63 9 proteins protein NNS cord-346964-9afuen7k 63 10 , , , cord-346964-9afuen7k 63 11 and and CC cord-346964-9afuen7k 63 12 carbohydrates carbohydrate NNS cord-346964-9afuen7k 63 13 are be VBP cord-346964-9afuen7k 63 14 hydrolyzed hydrolyze VBN cord-346964-9afuen7k 63 15 and and CC cord-346964-9afuen7k 63 16 stabilized stabilize VBN cord-346964-9afuen7k 63 17 by by IN cord-346964-9afuen7k 63 18 digestive digestive JJ cord-346964-9afuen7k 63 19 enzymes enzyme NNS cord-346964-9afuen7k 63 20 and and CC cord-346964-9afuen7k 63 21 bile bile NN cord-346964-9afuen7k 63 22 . . . cord-346964-9afuen7k 64 1 Diseases disease NNS cord-346964-9afuen7k 64 2 often often RB cord-346964-9afuen7k 64 3 associated associate VBN cord-346964-9afuen7k 64 4 with with IN cord-346964-9afuen7k 64 5 this this DT cord-346964-9afuen7k 64 6 phase phase NN cord-346964-9afuen7k 64 7 include include VBP cord-346964-9afuen7k 64 8 À à FW cord-346964-9afuen7k 64 9 enterokinase enterokinase NNP cord-346964-9afuen7k 64 10 and and CC cord-346964-9afuen7k 64 11 trypsinogen trypsinogen NN cord-346964-9afuen7k 64 12 deficiencies deficiency NNS cord-346964-9afuen7k 64 13 that that WDT cord-346964-9afuen7k 64 14 can can MD cord-346964-9afuen7k 64 15 lead lead VB cord-346964-9afuen7k 64 16 to to IN cord-346964-9afuen7k 64 17 protein protein NN cord-346964-9afuen7k 64 18 malabsorption malabsorption NN cord-346964-9afuen7k 64 19 , , , cord-346964-9afuen7k 64 20 À à FW cord-346964-9afuen7k 64 21 impaired impair VBN cord-346964-9afuen7k 64 22 micelle micelle NN cord-346964-9afuen7k 64 23 formation formation NN cord-346964-9afuen7k 64 24 that that WDT cord-346964-9afuen7k 64 25 can can MD cord-346964-9afuen7k 64 26 cause cause VB cord-346964-9afuen7k 64 27 problems problem NNS cord-346964-9afuen7k 64 28 in in IN cord-346964-9afuen7k 64 29 fat fat JJ cord-346964-9afuen7k 64 30 stabilization stabilization NN cord-346964-9afuen7k 64 31 and and CC cord-346964-9afuen7k 64 32 the the DT cord-346964-9afuen7k 64 33 resulting result VBG cord-346964-9afuen7k 64 34 fat fat JJ cord-346964-9afuen7k 64 35 malabsorption malabsorption NN cord-346964-9afuen7k 64 36 due due IN cord-346964-9afuen7k 64 37 to to IN cord-346964-9afuen7k 64 38 deconjugation deconjugation NN cord-346964-9afuen7k 64 39 of of IN cord-346964-9afuen7k 64 40 bile bile NN cord-346964-9afuen7k 64 41 salts salt NNS cord-346964-9afuen7k 64 42 , , , cord-346964-9afuen7k 64 43 À à NN cord-346964-9afuen7k 64 44 stasis stasis NN cord-346964-9afuen7k 64 45 of of IN cord-346964-9afuen7k 64 46 intestinal intestinal JJ cord-346964-9afuen7k 64 47 content content NN cord-346964-9afuen7k 64 48 due due IN cord-346964-9afuen7k 64 49 to to IN cord-346964-9afuen7k 64 50 a a DT cord-346964-9afuen7k 64 51 variety variety NN cord-346964-9afuen7k 64 52 of of IN cord-346964-9afuen7k 64 53 factors factor NNS cord-346964-9afuen7k 64 54 ( ( -LRB- cord-346964-9afuen7k 64 55 motor motor NN cord-346964-9afuen7k 64 56 and and CC cord-346964-9afuen7k 64 57 anatomical anatomical JJ cord-346964-9afuen7k 64 58 abnormalities abnormality NNS cord-346964-9afuen7k 64 59 and and CC cord-346964-9afuen7k 64 60 small small JJ cord-346964-9afuen7k 64 61 bowel bowel NN cord-346964-9afuen7k 64 62 contamination contamination NN cord-346964-9afuen7k 64 63 from from IN cord-346964-9afuen7k 64 64 enterocolonic enterocolonic NNP cord-346964-9afuen7k 64 65 fistulas fistula NNS cord-346964-9afuen7k 64 66 ) ) -RRB- cord-346964-9afuen7k 64 67 that that WDT cord-346964-9afuen7k 64 68 can can MD cord-346964-9afuen7k 64 69 cause cause VB cord-346964-9afuen7k 64 70 bacterial bacterial JJ cord-346964-9afuen7k 64 71 overgrowth overgrowth NN cord-346964-9afuen7k 64 72 . . . cord-346964-9afuen7k 65 1 2 2 LS cord-346964-9afuen7k 65 2 . . . cord-346964-9afuen7k 66 1 Bacterial bacterial JJ cord-346964-9afuen7k 66 2 overgrowth overgrowth NN cord-346964-9afuen7k 66 3 can can MD cord-346964-9afuen7k 66 4 cause cause VB cord-346964-9afuen7k 66 5 decreased decrease VBN cord-346964-9afuen7k 66 6 luminal luminal JJ cord-346964-9afuen7k 66 7 availability availability NN cord-346964-9afuen7k 66 8 of of IN cord-346964-9afuen7k 66 9 substrates substrate NNS cord-346964-9afuen7k 66 10 ( ( -LRB- cord-346964-9afuen7k 66 11 carbohydrates carbohydrate NNS cord-346964-9afuen7k 66 12 , , , cord-346964-9afuen7k 66 13 protein protein NN cord-346964-9afuen7k 66 14 , , , cord-346964-9afuen7k 66 15 and and CC cord-346964-9afuen7k 66 16 vitamins vitamin NNS cord-346964-9afuen7k 66 17 ) ) -RRB- cord-346964-9afuen7k 66 18 . . . cord-346964-9afuen7k 67 1 À à NN cord-346964-9afuen7k 68 1 The the DT cord-346964-9afuen7k 68 2 mucosal mucosal JJ cord-346964-9afuen7k 68 3 phase phase NN cord-346964-9afuen7k 68 4 relies rely VBZ cord-346964-9afuen7k 68 5 on on IN cord-346964-9afuen7k 68 6 the the DT cord-346964-9afuen7k 68 7 integrity integrity NN cord-346964-9afuen7k 68 8 of of IN cord-346964-9afuen7k 68 9 the the DT cord-346964-9afuen7k 68 10 brush brush NN cord-346964-9afuen7k 68 11 border border NN cord-346964-9afuen7k 68 12 membrane membrane NN cord-346964-9afuen7k 68 13 of of IN cord-346964-9afuen7k 68 14 intestinal intestinal JJ cord-346964-9afuen7k 68 15 epithelial epithelial JJ cord-346964-9afuen7k 68 16 cells cell NNS cord-346964-9afuen7k 68 17 to to TO cord-346964-9afuen7k 68 18 transport transport VB cord-346964-9afuen7k 68 19 digested digest VBN cord-346964-9afuen7k 68 20 products product NNS cord-346964-9afuen7k 68 21 from from IN cord-346964-9afuen7k 68 22 the the DT cord-346964-9afuen7k 68 23 lumen lumen NN cord-346964-9afuen7k 68 24 into into IN cord-346964-9afuen7k 68 25 the the DT cord-346964-9afuen7k 68 26 cells cell NNS cord-346964-9afuen7k 68 27 . . . cord-346964-9afuen7k 69 1 À à LS cord-346964-9afuen7k 69 2 Impaired impaired JJ cord-346964-9afuen7k 69 3 brush brush NN cord-346964-9afuen7k 69 4 border border NN cord-346964-9afuen7k 69 5 enzyme enzyme NN cord-346964-9afuen7k 69 6 activity activity NN cord-346964-9afuen7k 69 7 may may MD cord-346964-9afuen7k 69 8 lead lead VB cord-346964-9afuen7k 69 9 to to IN cord-346964-9afuen7k 69 10 lactose lactose JJ cord-346964-9afuen7k 69 11 intolerance intolerance NN cord-346964-9afuen7k 69 12 and and CC cord-346964-9afuen7k 69 13 sucrase sucrase NN cord-346964-9afuen7k 69 14 - - HYPH cord-346964-9afuen7k 69 15 isomaltase isomaltase NN cord-346964-9afuen7k 69 16 deficiency deficiency NN cord-346964-9afuen7k 69 17 . . . cord-346964-9afuen7k 70 1 Infectious Infectious NNP cord-346964-9afuen7k 70 2 Chemical Chemical NNP cord-346964-9afuen7k 70 3 / / SYM cord-346964-9afuen7k 70 4 toxic toxic JJ cord-346964-9afuen7k 70 5 HC1 HC1 NNP cord-346964-9afuen7k 70 6 HC1 HC1 NNP cord-346964-9afuen7k 70 7 Figure Figure NNP cord-346964-9afuen7k 70 8 1 1 CD cord-346964-9afuen7k 70 9 Malabsorption malabsorption NN cord-346964-9afuen7k 70 10 develops develop VBZ cord-346964-9afuen7k 70 11 when when WRB cord-346964-9afuen7k 70 12 components component NNS cord-346964-9afuen7k 70 13 of of IN cord-346964-9afuen7k 70 14 the the DT cord-346964-9afuen7k 70 15 mucosa mucosa NN cord-346964-9afuen7k 70 16 are be VBP cord-346964-9afuen7k 70 17 disrupted disrupt VBN cord-346964-9afuen7k 70 18 or or CC cord-346964-9afuen7k 70 19 damaged damage VBN cord-346964-9afuen7k 70 20 by by IN cord-346964-9afuen7k 70 21 a a DT cord-346964-9afuen7k 70 22 wide wide JJ cord-346964-9afuen7k 70 23 variety variety NN cord-346964-9afuen7k 70 24 of of IN cord-346964-9afuen7k 70 25 injuries injury NNS cord-346964-9afuen7k 70 26 or or CC cord-346964-9afuen7k 70 27 stimuli stimulus NNS cord-346964-9afuen7k 70 28 including include VBG cord-346964-9afuen7k 70 29 infectious infectious JJ cord-346964-9afuen7k 70 30 , , , cord-346964-9afuen7k 70 31 immunologic immunologic JJ cord-346964-9afuen7k 70 32 and and CC cord-346964-9afuen7k 70 33 inflammatory inflammatory JJ cord-346964-9afuen7k 70 34 , , , cord-346964-9afuen7k 70 35 and and CC cord-346964-9afuen7k 70 36 toxic toxic JJ cord-346964-9afuen7k 70 37 or or CC cord-346964-9afuen7k 70 38 chemical chemical JJ cord-346964-9afuen7k 70 39 causes cause NNS cord-346964-9afuen7k 70 40 . . . cord-346964-9afuen7k 71 1 À à LS cord-346964-9afuen7k 71 2 Impaired impaired JJ cord-346964-9afuen7k 71 3 nutrient nutrient NN cord-346964-9afuen7k 71 4 absorption absorption NN cord-346964-9afuen7k 71 5 can can MD cord-346964-9afuen7k 71 6 be be VB cord-346964-9afuen7k 71 7 inherited inherit VBN cord-346964-9afuen7k 71 8 or or CC cord-346964-9afuen7k 71 9 acquired acquire VBN cord-346964-9afuen7k 71 10 deficits deficit NNS cord-346964-9afuen7k 71 11 . . . cord-346964-9afuen7k 72 1 Inherited inherit VBN cord-346964-9afuen7k 72 2 defects defect NNS cord-346964-9afuen7k 72 3 include include VBP cord-346964-9afuen7k 72 4 glucosegalactose glucosegalactose VBN cord-346964-9afuen7k 72 5 malabsorption malabsorption NN cord-346964-9afuen7k 72 6 and and CC cord-346964-9afuen7k 72 7 abetalipoproteinemia abetalipoproteinemia NN cord-346964-9afuen7k 72 8 . . . cord-346964-9afuen7k 73 1 À à FW cord-346964-9afuen7k 73 2 Acquired acquire VBN cord-346964-9afuen7k 73 3 defects defect NNS cord-346964-9afuen7k 73 4 that that WDT cord-346964-9afuen7k 73 5 are be VBP cord-346964-9afuen7k 73 6 more more RBR cord-346964-9afuen7k 73 7 common common JJ cord-346964-9afuen7k 73 8 may may MD cord-346964-9afuen7k 73 9 be be VB cord-346964-9afuen7k 73 10 caused cause VBN cord-346964-9afuen7k 73 11 by by IN cord-346964-9afuen7k 73 12 decreased decreased JJ cord-346964-9afuen7k 73 13 absorptive absorptive JJ cord-346964-9afuen7k 73 14 surface surface NN cord-346964-9afuen7k 73 15 area area NN cord-346964-9afuen7k 73 16 ( ( -LRB- cord-346964-9afuen7k 73 17 intestinal intestinal JJ cord-346964-9afuen7k 73 18 resection resection NN cord-346964-9afuen7k 73 19 ) ) -RRB- cord-346964-9afuen7k 73 20 or or CC cord-346964-9afuen7k 73 21 damaged damage VBN cord-346964-9afuen7k 73 22 mucosa mucosa JJ cord-346964-9afuen7k 73 23 ( ( -LRB- cord-346964-9afuen7k 73 24 celiac celiac JJ cord-346964-9afuen7k 73 25 sprue sprue NN cord-346964-9afuen7k 73 26 , , , cord-346964-9afuen7k 73 27 tropical tropical JJ cord-346964-9afuen7k 73 28 sprue sprue NN cord-346964-9afuen7k 73 29 , , , cord-346964-9afuen7k 73 30 giardiasis giardiasis NN cord-346964-9afuen7k 73 31 , , , cord-346964-9afuen7k 73 32 and and CC cord-346964-9afuen7k 73 33 Crohn Crohn NNP cord-346964-9afuen7k 73 34 's 's POS cord-346964-9afuen7k 73 35 disease disease NN cord-346964-9afuen7k 73 36 ) ) -RRB- cord-346964-9afuen7k 73 37 . . . cord-346964-9afuen7k 74 1 3 3 LS cord-346964-9afuen7k 74 2 . . . cord-346964-9afuen7k 75 1 Transport transport NN cord-346964-9afuen7k 75 2 abnormalities abnormality NNS cord-346964-9afuen7k 75 3 may may MD cord-346964-9afuen7k 75 4 be be VB cord-346964-9afuen7k 75 5 caused cause VBN cord-346964-9afuen7k 75 6 by by IN cord-346964-9afuen7k 75 7 lymphatic lymphatic JJ cord-346964-9afuen7k 75 8 obstruction obstruction NN cord-346964-9afuen7k 75 9 or or CC cord-346964-9afuen7k 75 10 vascular vascular JJ cord-346964-9afuen7k 75 11 insufficiency insufficiency NN cord-346964-9afuen7k 75 12 . . . cord-346964-9afuen7k 76 1 These these DT cord-346964-9afuen7k 76 2 include include VBP cord-346964-9afuen7k 76 3 conditions condition NNS cord-346964-9afuen7k 76 4 like like IN cord-346964-9afuen7k 76 5 defective defective JJ cord-346964-9afuen7k 76 6 chylomicron chylomicron NNP cord-346964-9afuen7k 76 7 synthesis synthesis NN cord-346964-9afuen7k 76 8 in in IN cord-346964-9afuen7k 76 9 abetalipoproteinemia abetalipoproteinemia NNP cord-346964-9afuen7k 76 10 , , , cord-346964-9afuen7k 76 11 submucosal submucosal NNP cord-346964-9afuen7k 76 12 infiltration infiltration NN cord-346964-9afuen7k 76 13 in in IN cord-346964-9afuen7k 76 14 the the DT cord-346964-9afuen7k 76 15 intestinal intestinal JJ cord-346964-9afuen7k 76 16 wall wall NN cord-346964-9afuen7k 76 17 due due IN cord-346964-9afuen7k 76 18 to to IN cord-346964-9afuen7k 76 19 lymphoma lymphoma NN cord-346964-9afuen7k 76 20 or or CC cord-346964-9afuen7k 76 21 amyloidosis amyloidosis NN cord-346964-9afuen7k 76 22 , , , cord-346964-9afuen7k 76 23 and and CC cord-346964-9afuen7k 76 24 lymphatic lymphatic JJ cord-346964-9afuen7k 76 25 obstruction obstruction NN cord-346964-9afuen7k 76 26 in in IN cord-346964-9afuen7k 76 27 intestinal intestinal JJ cord-346964-9afuen7k 76 28 lymphangiectasia lymphangiectasia NNS cord-346964-9afuen7k 76 29 . . . cord-346964-9afuen7k 77 1 Figure figure NN cord-346964-9afuen7k 77 2 2 2 CD cord-346964-9afuen7k 77 3 summarizes summarize VBZ cord-346964-9afuen7k 77 4 the the DT cord-346964-9afuen7k 77 5 phases phase NNS cord-346964-9afuen7k 77 6 of of IN cord-346964-9afuen7k 77 7 malabsorption malabsorption NN cord-346964-9afuen7k 77 8 . . . cord-346964-9afuen7k 78 1 Regardless regardless RB cord-346964-9afuen7k 78 2 of of IN cord-346964-9afuen7k 78 3 the the DT cord-346964-9afuen7k 78 4 cause cause NN cord-346964-9afuen7k 78 5 , , , cord-346964-9afuen7k 78 6 malabsorption malabsorption NN cord-346964-9afuen7k 78 7 syndrome syndrome NN cord-346964-9afuen7k 78 8 refers refer VBZ cord-346964-9afuen7k 78 9 to to IN cord-346964-9afuen7k 78 10 the the DT cord-346964-9afuen7k 78 11 clinical clinical JJ cord-346964-9afuen7k 78 12 picture picture NN cord-346964-9afuen7k 78 13 comprising comprise VBG cord-346964-9afuen7k 78 14 diarrhea diarrhea NN cord-346964-9afuen7k 78 15 , , , cord-346964-9afuen7k 78 16 steatorrhea steatorrhea NN cord-346964-9afuen7k 78 17 , , , cord-346964-9afuen7k 78 18 malnutrition malnutrition NN cord-346964-9afuen7k 78 19 , , , cord-346964-9afuen7k 78 20 weight weight NN cord-346964-9afuen7k 78 21 loss loss NN cord-346964-9afuen7k 78 22 , , , cord-346964-9afuen7k 78 23 abdominal abdominal JJ cord-346964-9afuen7k 78 24 pain pain NN cord-346964-9afuen7k 78 25 , , , cord-346964-9afuen7k 78 26 and and CC cord-346964-9afuen7k 78 27 anemia anemia NN cord-346964-9afuen7k 78 28 . . . cord-346964-9afuen7k 79 1 Undigested undigested JJ cord-346964-9afuen7k 79 2 food food NN cord-346964-9afuen7k 79 3 produces produce VBZ cord-346964-9afuen7k 79 4 diarrhea diarrhea NN cord-346964-9afuen7k 79 5 , , , cord-346964-9afuen7k 79 6 due due IN cord-346964-9afuen7k 79 7 to to IN cord-346964-9afuen7k 79 8 its -PRON- PRP$ cord-346964-9afuen7k 79 9 voluminous voluminous JJ cord-346964-9afuen7k 79 10 effect effect NN cord-346964-9afuen7k 79 11 in in IN cord-346964-9afuen7k 79 12 the the DT cord-346964-9afuen7k 79 13 bowel bowel NN cord-346964-9afuen7k 79 14 lumen lumen NN cord-346964-9afuen7k 79 15 . . . cord-346964-9afuen7k 80 1 Although although IN cord-346964-9afuen7k 80 2 all all DT cord-346964-9afuen7k 80 3 three three CD cord-346964-9afuen7k 80 4 major major JJ cord-346964-9afuen7k 80 5 nutrients nutrient NNS cord-346964-9afuen7k 80 6 ( ( -LRB- cord-346964-9afuen7k 80 7 fat fat JJ cord-346964-9afuen7k 80 8 , , , cord-346964-9afuen7k 80 9 carbohydrate carbohydrate NN cord-346964-9afuen7k 80 10 , , , cord-346964-9afuen7k 80 11 and and CC cord-346964-9afuen7k 80 12 protein protein NN cord-346964-9afuen7k 80 13 ) ) -RRB- cord-346964-9afuen7k 80 14 may may MD cord-346964-9afuen7k 80 15 be be VB cord-346964-9afuen7k 80 16 malabsorbed malabsorbed JJ cord-346964-9afuen7k 80 17 , , , cord-346964-9afuen7k 80 18 clinical clinical JJ cord-346964-9afuen7k 80 19 symptoms symptom NNS cord-346964-9afuen7k 80 20 usually usually RB cord-346964-9afuen7k 80 21 only only RB cord-346964-9afuen7k 80 22 develop develop VBP cord-346964-9afuen7k 80 23 with with IN cord-346964-9afuen7k 80 24 carbohydrate carbohydrate NN cord-346964-9afuen7k 80 25 and and CC cord-346964-9afuen7k 80 26 fat fat JJ cord-346964-9afuen7k 80 27 malabsorption malabsorption NN cord-346964-9afuen7k 80 28 . . . cord-346964-9afuen7k 81 1 Small small JJ cord-346964-9afuen7k 81 2 intestinal intestinal JJ cord-346964-9afuen7k 81 3 biopsy biopsy NN cord-346964-9afuen7k 81 4 is be VBZ cord-346964-9afuen7k 81 5 an an DT cord-346964-9afuen7k 81 6 indispensable indispensable JJ cord-346964-9afuen7k 81 7 component component NN cord-346964-9afuen7k 81 8 of of IN cord-346964-9afuen7k 81 9 the the DT cord-346964-9afuen7k 81 10 diagnostic diagnostic JJ cord-346964-9afuen7k 81 11 work work NN cord-346964-9afuen7k 81 12 - - HYPH cord-346964-9afuen7k 81 13 up up NN cord-346964-9afuen7k 81 14 of of IN cord-346964-9afuen7k 81 15 patients patient NNS cord-346964-9afuen7k 81 16 with with IN cord-346964-9afuen7k 81 17 malabsorption malabsorption NN cord-346964-9afuen7k 81 18 and/or and/or CC cord-346964-9afuen7k 81 19 chronic chronic JJ cord-346964-9afuen7k 81 20 diarrhea diarrhea NN cord-346964-9afuen7k 81 21 secondary secondary JJ cord-346964-9afuen7k 81 22 to to IN cord-346964-9afuen7k 81 23 mucosal mucosal JJ cord-346964-9afuen7k 81 24 damage damage NN cord-346964-9afuen7k 81 25 . . . cord-346964-9afuen7k 82 1 Though though IN cord-346964-9afuen7k 82 2 complete complete JJ cord-346964-9afuen7k 82 3 villous villous NN cord-346964-9afuen7k 82 4 flattening flatten VBG cord-346964-9afuen7k 82 5 usually usually RB cord-346964-9afuen7k 82 6 indicates indicate VBZ cord-346964-9afuen7k 82 7 CD cd NN cord-346964-9afuen7k 82 8 when when WRB cord-346964-9afuen7k 82 9 coexisting coexist VBG cord-346964-9afuen7k 82 10 crypt crypt JJ cord-346964-9afuen7k 82 11 hyperplasia hyperplasia NN cord-346964-9afuen7k 82 12 is be VBZ cord-346964-9afuen7k 82 13 present present JJ cord-346964-9afuen7k 82 14 , , , cord-346964-9afuen7k 82 15 there there EX cord-346964-9afuen7k 82 16 are be VBP cord-346964-9afuen7k 82 17 entities entity NNS cord-346964-9afuen7k 82 18 that that WDT cord-346964-9afuen7k 82 19 may may MD cord-346964-9afuen7k 82 20 cause cause VB cord-346964-9afuen7k 82 21 villous villous NNP cord-346964-9afuen7k 82 22 flattening flatten VBG cord-346964-9afuen7k 82 23 and and CC cord-346964-9afuen7k 82 24 crypt crypt JJ cord-346964-9afuen7k 82 25 hyperplasia hyperplasia NN cord-346964-9afuen7k 82 26 other other JJ cord-346964-9afuen7k 82 27 than than IN cord-346964-9afuen7k 82 28 CD CD NNP cord-346964-9afuen7k 82 29 . . . cord-346964-9afuen7k 83 1 The the DT cord-346964-9afuen7k 83 2 majority majority NN cord-346964-9afuen7k 83 3 of of IN cord-346964-9afuen7k 83 4 disorders disorder NNS cord-346964-9afuen7k 83 5 causing cause VBG cord-346964-9afuen7k 83 6 malabsorption malabsorption NN cord-346964-9afuen7k 83 7 , , , cord-346964-9afuen7k 83 8 on on IN cord-346964-9afuen7k 83 9 the the DT cord-346964-9afuen7k 83 10 other other JJ cord-346964-9afuen7k 83 11 hand hand NN cord-346964-9afuen7k 83 12 , , , cord-346964-9afuen7k 83 13 produce produce VBP cord-346964-9afuen7k 83 14 mild mild JJ cord-346964-9afuen7k 83 15 to to IN cord-346964-9afuen7k 83 16 moderate moderate JJ cord-346964-9afuen7k 83 17 villus villus NN cord-346964-9afuen7k 83 18 blunting blunting NN cord-346964-9afuen7k 83 19 and and CC cord-346964-9afuen7k 83 20 crypt crypt JJ cord-346964-9afuen7k 83 21 hyperplasia hyperplasia NN cord-346964-9afuen7k 83 22 without without IN cord-346964-9afuen7k 83 23 any any DT cord-346964-9afuen7k 83 24 specific specific JJ cord-346964-9afuen7k 83 25 diagnostic diagnostic JJ cord-346964-9afuen7k 83 26 feature feature NN cord-346964-9afuen7k 83 27 . . . cord-346964-9afuen7k 84 1 Pathologists pathologist NNS cord-346964-9afuen7k 84 2 can can MD cord-346964-9afuen7k 84 3 also also RB cord-346964-9afuen7k 84 4 be be VB cord-346964-9afuen7k 84 5 faced face VBN cord-346964-9afuen7k 84 6 with with IN cord-346964-9afuen7k 84 7 a a DT cord-346964-9afuen7k 84 8 patient patient NN cord-346964-9afuen7k 84 9 with with IN cord-346964-9afuen7k 84 10 malabsorption malabsorption NN cord-346964-9afuen7k 84 11 or or CC cord-346964-9afuen7k 84 12 chronic chronic JJ cord-346964-9afuen7k 84 13 diarrhea diarrhea NN cord-346964-9afuen7k 84 14 and and CC cord-346964-9afuen7k 84 15 a a DT cord-346964-9afuen7k 84 16 biopsy biopsy NN cord-346964-9afuen7k 84 17 that that WDT cord-346964-9afuen7k 84 18 appears appear VBZ cord-346964-9afuen7k 84 19 normal normal JJ cord-346964-9afuen7k 84 20 or or CC cord-346964-9afuen7k 84 21 near near RB cord-346964-9afuen7k 84 22 - - HYPH cord-346964-9afuen7k 84 23 normal normal JJ cord-346964-9afuen7k 84 24 architecturally architecturally RB cord-346964-9afuen7k 84 25 on on IN cord-346964-9afuen7k 84 26 microscopy microscopy NNS cord-346964-9afuen7k 84 27 . . . cord-346964-9afuen7k 85 1 Table table NN cord-346964-9afuen7k 85 2 3 3 CD cord-346964-9afuen7k 85 3 highlights highlight NNS cord-346964-9afuen7k 85 4 mucosal mucosal JJ cord-346964-9afuen7k 85 5 pathology pathology NN cord-346964-9afuen7k 85 6 of of IN cord-346964-9afuen7k 85 7 malabsorption malabsorption NN cord-346964-9afuen7k 85 8 . . . cord-346964-9afuen7k 86 1 Digestion digestion NN cord-346964-9afuen7k 86 2 begins begin VBZ cord-346964-9afuen7k 86 3 in in IN cord-346964-9afuen7k 86 4 the the DT cord-346964-9afuen7k 86 5 mouth mouth NN cord-346964-9afuen7k 86 6 with with IN cord-346964-9afuen7k 86 7 mechanical mechanical JJ cord-346964-9afuen7k 86 8 disruption disruption NN cord-346964-9afuen7k 86 9 of of IN cord-346964-9afuen7k 86 10 food food NN cord-346964-9afuen7k 86 11 by by IN cord-346964-9afuen7k 86 12 chewing chew VBG cord-346964-9afuen7k 86 13 and and CC cord-346964-9afuen7k 86 14 mixing mix VBG cord-346964-9afuen7k 86 15 it -PRON- PRP cord-346964-9afuen7k 86 16 with with IN cord-346964-9afuen7k 86 17 enzymes enzyme NNS cord-346964-9afuen7k 86 18 in in IN cord-346964-9afuen7k 86 19 the the DT cord-346964-9afuen7k 86 20 saliva saliva NN cord-346964-9afuen7k 86 21 . . . cord-346964-9afuen7k 87 1 Further further JJ cord-346964-9afuen7k 87 2 mechanical mechanical JJ cord-346964-9afuen7k 87 3 digestion digestion NN cord-346964-9afuen7k 87 4 continues continue VBZ cord-346964-9afuen7k 87 5 in in IN cord-346964-9afuen7k 87 6 the the DT cord-346964-9afuen7k 87 7 stomach stomach NN cord-346964-9afuen7k 87 8 until until IN cord-346964-9afuen7k 87 9 the the DT cord-346964-9afuen7k 87 10 semiliquid semiliquid JJ cord-346964-9afuen7k 87 11 food food NN cord-346964-9afuen7k 87 12 or or CC cord-346964-9afuen7k 87 13 chyme chyme NN cord-346964-9afuen7k 87 14 is be VBZ cord-346964-9afuen7k 87 15 formed form VBN cord-346964-9afuen7k 87 16 . . . cord-346964-9afuen7k 88 1 Digestion digestion NN cord-346964-9afuen7k 88 2 is be VBZ cord-346964-9afuen7k 88 3 completed complete VBN cord-346964-9afuen7k 88 4 when when WRB cord-346964-9afuen7k 88 5 chyme chyme NN cord-346964-9afuen7k 88 6 is be VBZ cord-346964-9afuen7k 88 7 delivered deliver VBN cord-346964-9afuen7k 88 8 into into IN cord-346964-9afuen7k 88 9 the the DT cord-346964-9afuen7k 88 10 duodenum duodenum NN cord-346964-9afuen7k 88 11 and and CC cord-346964-9afuen7k 88 12 treated treat VBN cord-346964-9afuen7k 88 13 with with IN cord-346964-9afuen7k 88 14 pancreatic pancreatic JJ cord-346964-9afuen7k 88 15 enzymes enzyme NNS cord-346964-9afuen7k 88 16 and and CC cord-346964-9afuen7k 88 17 bile bile NN cord-346964-9afuen7k 88 18 salts salt NNS cord-346964-9afuen7k 88 19 . . . cord-346964-9afuen7k 89 1 When when WRB cord-346964-9afuen7k 89 2 normal normal JJ cord-346964-9afuen7k 89 3 gastric gastric JJ cord-346964-9afuen7k 89 4 function function NN cord-346964-9afuen7k 89 5 is be VBZ cord-346964-9afuen7k 89 6 lost lose VBN cord-346964-9afuen7k 89 7 due due IN cord-346964-9afuen7k 89 8 to to IN cord-346964-9afuen7k 89 9 surgical surgical JJ cord-346964-9afuen7k 89 10 procedures procedure NNS cord-346964-9afuen7k 89 11 such such JJ cord-346964-9afuen7k 89 12 as as IN cord-346964-9afuen7k 89 13 partial partial JJ cord-346964-9afuen7k 89 14 or or CC cord-346964-9afuen7k 89 15 total total JJ cord-346964-9afuen7k 89 16 gastrectomy gastrectomy NN cord-346964-9afuen7k 89 17 , , , cord-346964-9afuen7k 89 18 the the DT cord-346964-9afuen7k 89 19 partially partially RB cord-346964-9afuen7k 89 20 digested digest VBN cord-346964-9afuen7k 89 21 food food NN cord-346964-9afuen7k 89 22 rapidly rapidly RB cord-346964-9afuen7k 89 23 passes pass VBZ cord-346964-9afuen7k 89 24 into into IN cord-346964-9afuen7k 89 25 the the DT cord-346964-9afuen7k 89 26 duodenum duodenum NN cord-346964-9afuen7k 89 27 causing cause VBG cord-346964-9afuen7k 89 28 osmotic osmotic JJ cord-346964-9afuen7k 89 29 pressure pressure NN cord-346964-9afuen7k 89 30 and and CC cord-346964-9afuen7k 89 31 diarrhea diarrhea NN cord-346964-9afuen7k 89 32 . . . cord-346964-9afuen7k 90 1 Enzymatic enzymatic JJ cord-346964-9afuen7k 90 2 activity activity NN cord-346964-9afuen7k 90 3 is be VBZ cord-346964-9afuen7k 90 4 equally equally RB cord-346964-9afuen7k 90 5 crucial crucial JJ cord-346964-9afuen7k 90 6 for for IN cord-346964-9afuen7k 90 7 absorption absorption NN cord-346964-9afuen7k 90 8 of of IN cord-346964-9afuen7k 90 9 nutrients nutrient NNS cord-346964-9afuen7k 90 10 . . . cord-346964-9afuen7k 91 1 Pancreatic pancreatic JJ cord-346964-9afuen7k 91 2 enzymes enzyme NNS cord-346964-9afuen7k 91 3 and and CC cord-346964-9afuen7k 91 4 intestinal intestinal JJ cord-346964-9afuen7k 91 5 brush brush NN cord-346964-9afuen7k 91 6 border border NN cord-346964-9afuen7k 91 7 hydrolases hydrolase NNS cord-346964-9afuen7k 91 8 act act VBP cord-346964-9afuen7k 91 9 in in IN cord-346964-9afuen7k 91 10 harmony harmony NN cord-346964-9afuen7k 91 11 for for IN cord-346964-9afuen7k 91 12 chemical chemical JJ cord-346964-9afuen7k 91 13 modification modification NN cord-346964-9afuen7k 91 14 of of IN cord-346964-9afuen7k 91 15 complex complex JJ cord-346964-9afuen7k 91 16 carbohydrates carbohydrate NNS cord-346964-9afuen7k 91 17 , , , cord-346964-9afuen7k 91 18 proteins protein NNS cord-346964-9afuen7k 91 19 , , , cord-346964-9afuen7k 91 20 and and CC cord-346964-9afuen7k 91 21 lipids lipid NNS cord-346964-9afuen7k 91 22 . . . cord-346964-9afuen7k 92 1 Therefore therefore RB cord-346964-9afuen7k 92 2 , , , cord-346964-9afuen7k 92 3 any any DT cord-346964-9afuen7k 92 4 disorder disorder NN cord-346964-9afuen7k 92 5 causing cause VBG cord-346964-9afuen7k 92 6 defective defective JJ cord-346964-9afuen7k 92 7 nutrient nutrient NN cord-346964-9afuen7k 92 8 hydrolysis hydrolysis NN cord-346964-9afuen7k 92 9 as as IN cord-346964-9afuen7k 92 10 in in IN cord-346964-9afuen7k 92 11 Zollinger Zollinger NNP cord-346964-9afuen7k 92 12 - - HYPH cord-346964-9afuen7k 92 13 Ellison Ellison NNP cord-346964-9afuen7k 92 14 syndrome syndrome NN cord-346964-9afuen7k 92 15 ( ( -LRB- cord-346964-9afuen7k 92 16 ZES ZES NNP cord-346964-9afuen7k 92 17 ) ) -RRB- cord-346964-9afuen7k 92 18 where where WRB cord-346964-9afuen7k 92 19 excess excess JJ cord-346964-9afuen7k 92 20 HCl HCl NNP cord-346964-9afuen7k 92 21 ( ( -LRB- cord-346964-9afuen7k 92 22 acid acid NN cord-346964-9afuen7k 92 23 ) ) -RRB- cord-346964-9afuen7k 92 24 production production NN cord-346964-9afuen7k 92 25 may may MD cord-346964-9afuen7k 92 26 inactivate inactivate VB cord-346964-9afuen7k 92 27 gastric gastric JJ cord-346964-9afuen7k 92 28 lipase lipase NN cord-346964-9afuen7k 92 29 and and CC cord-346964-9afuen7k 92 30 proteolytic proteolytic JJ cord-346964-9afuen7k 92 31 pancreatic pancreatic JJ cord-346964-9afuen7k 92 32 exocrine exocrine JJ cord-346964-9afuen7k 92 33 enzymes enzyme NNS cord-346964-9afuen7k 92 34 , , , cord-346964-9afuen7k 92 35 pancreatic pancreatic JJ cord-346964-9afuen7k 92 36 enzyme enzyme NN cord-346964-9afuen7k 92 37 deficiency deficiency NN cord-346964-9afuen7k 92 38 due due IN cord-346964-9afuen7k 92 39 to to IN cord-346964-9afuen7k 92 40 chronic chronic JJ cord-346964-9afuen7k 92 41 pancreatitis pancreatitis NN cord-346964-9afuen7k 92 42 , , , cord-346964-9afuen7k 92 43 or or CC cord-346964-9afuen7k 92 44 a a DT cord-346964-9afuen7k 92 45 malignancy malignancy NN cord-346964-9afuen7k 92 46 obstructing obstruct VBG cord-346964-9afuen7k 92 47 the the DT cord-346964-9afuen7k 92 48 outflow outflow NN cord-346964-9afuen7k 92 49 of of IN cord-346964-9afuen7k 92 50 pancreatic pancreatic JJ cord-346964-9afuen7k 92 51 juices juice NNS cord-346964-9afuen7k 92 52 into into IN cord-346964-9afuen7k 92 53 the the DT cord-346964-9afuen7k 92 54 duodenum duodenum NN cord-346964-9afuen7k 92 55 may may MD cord-346964-9afuen7k 92 56 all all DT cord-346964-9afuen7k 92 57 lead lead VB cord-346964-9afuen7k 92 58 to to IN cord-346964-9afuen7k 92 59 malabsorption malabsorption NN cord-346964-9afuen7k 92 60 . . . cord-346964-9afuen7k 93 1 There there EX cord-346964-9afuen7k 93 2 are be VBP cord-346964-9afuen7k 93 3 reduced reduce VBN cord-346964-9afuen7k 93 4 bile bile NN cord-346964-9afuen7k 93 5 salt salt NN cord-346964-9afuen7k 93 6 synthesis synthesis NN cord-346964-9afuen7k 93 7 due due IN cord-346964-9afuen7k 93 8 to to IN cord-346964-9afuen7k 93 9 severe severe JJ cord-346964-9afuen7k 93 10 liver liver NN cord-346964-9afuen7k 93 11 disease disease NN cord-346964-9afuen7k 93 12 ( ( -LRB- cord-346964-9afuen7k 93 13 cirrhosis cirrhosis NN cord-346964-9afuen7k 93 14 ) ) -RRB- cord-346964-9afuen7k 93 15 and and CC cord-346964-9afuen7k 93 16 impaired impaired JJ cord-346964-9afuen7k 93 17 bile bile NN cord-346964-9afuen7k 93 18 salt salt NN cord-346964-9afuen7k 93 19 secretion secretion NN cord-346964-9afuen7k 93 20 due due IN cord-346964-9afuen7k 93 21 to to IN cord-346964-9afuen7k 93 22 chronic chronic JJ cord-346964-9afuen7k 93 23 cholestasis cholestasis NN cord-346964-9afuen7k 93 24 ( ( -LRB- cord-346964-9afuen7k 93 25 intrinsic intrinsic JJ cord-346964-9afuen7k 93 26 liver liver NN cord-346964-9afuen7k 93 27 disease disease NN cord-346964-9afuen7k 93 28 that that WDT cord-346964-9afuen7k 93 29 causes cause VBZ cord-346964-9afuen7k 93 30 bile bile NN cord-346964-9afuen7k 93 31 duct duct NN cord-346964-9afuen7k 93 32 damage damage NN cord-346964-9afuen7k 93 33 or or CC cord-346964-9afuen7k 93 34 extrahepatic extrahepatic JJ cord-346964-9afuen7k 93 35 bile bile NN cord-346964-9afuen7k 93 36 duct duct NN cord-346964-9afuen7k 93 37 obstruction obstruction NN cord-346964-9afuen7k 93 38 ) ) -RRB- cord-346964-9afuen7k 93 39 : : : cord-346964-9afuen7k 93 40 bile bile NN cord-346964-9afuen7k 93 41 salts salt NNS cord-346964-9afuen7k 93 42 are be VBP cord-346964-9afuen7k 93 43 thus thus RB cord-346964-9afuen7k 93 44 not not RB cord-346964-9afuen7k 93 45 available available JJ cord-346964-9afuen7k 93 46 to to TO cord-346964-9afuen7k 93 47 form form VB cord-346964-9afuen7k 93 48 micelles micelle NNS cord-346964-9afuen7k 93 49 to to TO cord-346964-9afuen7k 93 50 aid aid VB cord-346964-9afuen7k 93 51 in in IN cord-346964-9afuen7k 93 52 fat fat JJ cord-346964-9afuen7k 93 53 solubilization solubilization NN cord-346964-9afuen7k 93 54 for for IN cord-346964-9afuen7k 93 55 absorption absorption NN cord-346964-9afuen7k 93 56 . . . cord-346964-9afuen7k 94 1 Bile bile NN cord-346964-9afuen7k 94 2 salts salt NNS cord-346964-9afuen7k 94 3 may may MD cord-346964-9afuen7k 94 4 be be VB cord-346964-9afuen7k 94 5 inactivated inactivate VBN cord-346964-9afuen7k 94 6 in in IN cord-346964-9afuen7k 94 7 the the DT cord-346964-9afuen7k 94 8 intestinal intestinal JJ cord-346964-9afuen7k 94 9 lumen lumen NN cord-346964-9afuen7k 94 10 by by IN cord-346964-9afuen7k 94 11 overgrowth overgrowth NN cord-346964-9afuen7k 94 12 of of IN cord-346964-9afuen7k 94 13 bacteria bacteria NNS cord-346964-9afuen7k 94 14 in in IN cord-346964-9afuen7k 94 15 small small JJ cord-346964-9afuen7k 94 16 intestinal intestinal JJ cord-346964-9afuen7k 94 17 bacterial bacterial JJ cord-346964-9afuen7k 94 18 overgrowth overgrowth NN cord-346964-9afuen7k 94 19 syndrome syndrome NN cord-346964-9afuen7k 94 20 ( ( -LRB- cord-346964-9afuen7k 94 21 SIBO SIBO NNP cord-346964-9afuen7k 94 22 ) ) -RRB- cord-346964-9afuen7k 94 23 . . . cord-346964-9afuen7k 95 1 In in IN cord-346964-9afuen7k 95 2 patients patient NNS cord-346964-9afuen7k 95 3 with with IN cord-346964-9afuen7k 95 4 conditions condition NNS cord-346964-9afuen7k 95 5 that that WDT cord-346964-9afuen7k 95 6 predispose predispose VBP cord-346964-9afuen7k 95 7 to to TO cord-346964-9afuen7k 95 8 intestinal intestinal VB cord-346964-9afuen7k 95 9 stasis stasis NN cord-346964-9afuen7k 95 10 , , , cord-346964-9afuen7k 95 11 either either CC cord-346964-9afuen7k 95 12 by by IN cord-346964-9afuen7k 95 13 anatomical anatomical JJ cord-346964-9afuen7k 95 14 or or CC cord-346964-9afuen7k 95 15 motility motility NN cord-346964-9afuen7k 95 16 abnormalities abnormality NNS cord-346964-9afuen7k 95 17 bacteria bacteria NNS cord-346964-9afuen7k 95 18 may may MD cord-346964-9afuen7k 95 19 overgrow overgrow VB cord-346964-9afuen7k 95 20 in in IN cord-346964-9afuen7k 95 21 the the DT cord-346964-9afuen7k 95 22 proximal proximal JJ cord-346964-9afuen7k 95 23 small small JJ cord-346964-9afuen7k 95 24 intestine intestine NN cord-346964-9afuen7k 95 25 ( ( -LRB- cord-346964-9afuen7k 95 26 Figure figure NN cord-346964-9afuen7k 95 27 3 3 CD cord-346964-9afuen7k 95 28 ) ) -RRB- cord-346964-9afuen7k 95 29 . . . cord-346964-9afuen7k 96 1 These these DT cord-346964-9afuen7k 96 2 excess excess JJ cord-346964-9afuen7k 96 3 bacteria bacteria NNS cord-346964-9afuen7k 96 4 deconjugate deconjugate VBP cord-346964-9afuen7k 96 5 bile bile NN cord-346964-9afuen7k 96 6 salts salt NNS cord-346964-9afuen7k 96 7 leaving leave VBG cord-346964-9afuen7k 96 8 them -PRON- PRP cord-346964-9afuen7k 96 9 unconjugated unconjugated JJ cord-346964-9afuen7k 96 10 and and CC cord-346964-9afuen7k 96 11 unable unable JJ cord-346964-9afuen7k 96 12 to to TO cord-346964-9afuen7k 96 13 participate participate VB cord-346964-9afuen7k 96 14 in in IN cord-346964-9afuen7k 96 15 micelle micelle NN cord-346964-9afuen7k 96 16 formation formation NN cord-346964-9afuen7k 96 17 . . . cord-346964-9afuen7k 97 1 This this DT cord-346964-9afuen7k 97 2 leads lead VBZ cord-346964-9afuen7k 97 3 to to IN cord-346964-9afuen7k 97 4 malabsorption malabsorption NN cord-346964-9afuen7k 97 5 of of IN cord-346964-9afuen7k 97 6 fat fat NN cord-346964-9afuen7k 97 7 and and CC cord-346964-9afuen7k 97 8 fatsoluble fatsoluble JJ cord-346964-9afuen7k 97 9 vitamins vitamin NNS cord-346964-9afuen7k 97 10 A A NNP cord-346964-9afuen7k 97 11 , , , cord-346964-9afuen7k 97 12 D D NNP cord-346964-9afuen7k 97 13 , , , cord-346964-9afuen7k 97 14 E E NNP cord-346964-9afuen7k 97 15 , , , cord-346964-9afuen7k 97 16 and and CC cord-346964-9afuen7k 97 17 K. K. NNP cord-346964-9afuen7k 97 18 Disaccharidase Disaccharidase NNP cord-346964-9afuen7k 97 19 deficiency deficiency NN cord-346964-9afuen7k 97 20 including include VBG cord-346964-9afuen7k 97 21 lactase lactase NN cord-346964-9afuen7k 97 22 , , , cord-346964-9afuen7k 97 23 sucrase sucrase NN cord-346964-9afuen7k 97 24 , , , cord-346964-9afuen7k 97 25 and and CC cord-346964-9afuen7k 97 26 maltase maltase NN cord-346964-9afuen7k 97 27 deficiencies deficiency NNS cord-346964-9afuen7k 97 28 may may MD cord-346964-9afuen7k 97 29 be be VB cord-346964-9afuen7k 97 30 either either CC cord-346964-9afuen7k 97 31 primary primary JJ cord-346964-9afuen7k 97 32 or or CC cord-346964-9afuen7k 97 33 secondary secondary JJ cord-346964-9afuen7k 97 34 that that WDT cord-346964-9afuen7k 97 35 may may MD cord-346964-9afuen7k 97 36 be be VB cord-346964-9afuen7k 97 37 differentiated differentiate VBN cord-346964-9afuen7k 97 38 by by IN cord-346964-9afuen7k 97 39 histology histology NN cord-346964-9afuen7k 97 40 . . . cord-346964-9afuen7k 98 1 Low low JJ cord-346964-9afuen7k 98 2 levels level NNS cord-346964-9afuen7k 98 3 with with IN cord-346964-9afuen7k 98 4 normal normal JJ cord-346964-9afuen7k 98 5 histology histology NN cord-346964-9afuen7k 98 6 may may MD cord-346964-9afuen7k 98 7 suggest suggest VB cord-346964-9afuen7k 98 8 primary primary JJ cord-346964-9afuen7k 98 9 deficiency deficiency NN cord-346964-9afuen7k 98 10 , , , cord-346964-9afuen7k 98 11 while while IN cord-346964-9afuen7k 98 12 the the DT cord-346964-9afuen7k 98 13 preceding precede VBG cord-346964-9afuen7k 98 14 disorder disorder NN cord-346964-9afuen7k 98 15 such such JJ cord-346964-9afuen7k 98 16 as as IN cord-346964-9afuen7k 98 17 celiac celiac JJ cord-346964-9afuen7k 98 18 disease disease NN cord-346964-9afuen7k 98 19 may may MD cord-346964-9afuen7k 98 20 also also RB cord-346964-9afuen7k 98 21 be be VB cord-346964-9afuen7k 98 22 diagnosed diagnose VBN cord-346964-9afuen7k 98 23 by by IN cord-346964-9afuen7k 98 24 histology histology NN cord-346964-9afuen7k 98 25 in in IN cord-346964-9afuen7k 98 26 secondary secondary JJ cord-346964-9afuen7k 98 27 deficiency deficiency NN cord-346964-9afuen7k 98 28 . . . cord-346964-9afuen7k 99 1 Lactase lactase NN cord-346964-9afuen7k 99 2 deficiency deficiency NN cord-346964-9afuen7k 99 3 : : : cord-346964-9afuen7k 100 1 Among among IN cord-346964-9afuen7k 100 2 the the DT cord-346964-9afuen7k 100 3 disaccharidase disaccharidase NN cord-346964-9afuen7k 100 4 deficiencies deficiency NNS cord-346964-9afuen7k 100 5 , , , cord-346964-9afuen7k 100 6 lactase lactase NN cord-346964-9afuen7k 100 7 deficiency deficiency NN cord-346964-9afuen7k 100 8 is be VBZ cord-346964-9afuen7k 100 9 by by IN cord-346964-9afuen7k 100 10 far far RB cord-346964-9afuen7k 100 11 the the DT cord-346964-9afuen7k 100 12 most most RBS cord-346964-9afuen7k 100 13 common common JJ cord-346964-9afuen7k 100 14 form form NN cord-346964-9afuen7k 100 15 worldwide worldwide RB cord-346964-9afuen7k 100 16 . . . cord-346964-9afuen7k 101 1 Lactase lactase NN cord-346964-9afuen7k 101 2 is be VBZ cord-346964-9afuen7k 101 3 a a DT cord-346964-9afuen7k 101 4 disaccharidase disaccharidase NN cord-346964-9afuen7k 101 5 located locate VBN cord-346964-9afuen7k 101 6 on on IN cord-346964-9afuen7k 101 7 the the DT cord-346964-9afuen7k 101 8 surface surface NN cord-346964-9afuen7k 101 9 of of IN cord-346964-9afuen7k 101 10 intestinal intestinal JJ cord-346964-9afuen7k 101 11 microvilli microvilli NN cord-346964-9afuen7k 101 12 , , , cord-346964-9afuen7k 101 13 which which WDT cord-346964-9afuen7k 101 14 cleaves cleave VBZ cord-346964-9afuen7k 101 15 lactose lactose NN cord-346964-9afuen7k 101 16 to to IN cord-346964-9afuen7k 101 17 glucose glucose NN cord-346964-9afuen7k 101 18 and and CC cord-346964-9afuen7k 101 19 galactose galactose NN cord-346964-9afuen7k 101 20 . . . cord-346964-9afuen7k 102 1 Lactase lactase NN cord-346964-9afuen7k 102 2 deficiency deficiency NN cord-346964-9afuen7k 102 3 or or CC cord-346964-9afuen7k 102 4 hypolactasia hypolactasia NNP cord-346964-9afuen7k 102 5 in in IN cord-346964-9afuen7k 102 6 adulthood adulthood NN cord-346964-9afuen7k 102 7 causes cause VBZ cord-346964-9afuen7k 102 8 fermentation fermentation NN cord-346964-9afuen7k 102 9 of of IN cord-346964-9afuen7k 102 10 lactose lactose NN cord-346964-9afuen7k 102 11 by by IN cord-346964-9afuen7k 102 12 intestinal intestinal JJ cord-346964-9afuen7k 102 13 microflora microflora NN cord-346964-9afuen7k 102 14 resulting result VBG cord-346964-9afuen7k 102 15 in in IN cord-346964-9afuen7k 102 16 abdominal abdominal JJ cord-346964-9afuen7k 102 17 discomfort discomfort NN cord-346964-9afuen7k 102 18 and and CC cord-346964-9afuen7k 102 19 diarrhea diarrhea NN cord-346964-9afuen7k 102 20 . . . cord-346964-9afuen7k 103 1 The the DT cord-346964-9afuen7k 103 2 diarrhea diarrhea NN cord-346964-9afuen7k 103 3 is be VBZ cord-346964-9afuen7k 103 4 caused cause VBN cord-346964-9afuen7k 103 5 by by IN cord-346964-9afuen7k 103 6 the the DT cord-346964-9afuen7k 103 7 osmotic osmotic JJ cord-346964-9afuen7k 103 8 effects effect NNS cord-346964-9afuen7k 103 9 of of IN cord-346964-9afuen7k 103 10 lactose lactose NN cord-346964-9afuen7k 103 11 , , , cord-346964-9afuen7k 103 12 glucose glucose NN cord-346964-9afuen7k 103 13 , , , cord-346964-9afuen7k 103 14 and and CC cord-346964-9afuen7k 103 15 galactose galactose NN cord-346964-9afuen7k 103 16 in in IN cord-346964-9afuen7k 103 17 the the DT cord-346964-9afuen7k 103 18 colonic colonic JJ cord-346964-9afuen7k 103 19 lumen lumen NN cord-346964-9afuen7k 103 20 , , , cord-346964-9afuen7k 103 21 while while IN cord-346964-9afuen7k 103 22 short short JJ cord-346964-9afuen7k 103 23 - - HYPH cord-346964-9afuen7k 103 24 chain chain NN cord-346964-9afuen7k 103 25 fatty fatty JJ cord-346964-9afuen7k 103 26 acids acid NNS cord-346964-9afuen7k 103 27 produced produce VBN cord-346964-9afuen7k 103 28 by by IN cord-346964-9afuen7k 103 29 fermentation fermentation NN cord-346964-9afuen7k 103 30 of of IN cord-346964-9afuen7k 103 31 lactose lactose NN cord-346964-9afuen7k 103 32 cause cause NN cord-346964-9afuen7k 103 33 flatulence flatulence NN cord-346964-9afuen7k 103 34 ( ( -LRB- cord-346964-9afuen7k 103 35 Figure figure NN cord-346964-9afuen7k 103 36 4 4 CD cord-346964-9afuen7k 103 37 ) ) -RRB- cord-346964-9afuen7k 103 38 . . . cord-346964-9afuen7k 104 1 Rare rare JJ cord-346964-9afuen7k 104 2 primary primary JJ cord-346964-9afuen7k 104 3 congenital congenital JJ cord-346964-9afuen7k 104 4 deficiency deficiency NN cord-346964-9afuen7k 104 5 may may MD cord-346964-9afuen7k 104 6 occur occur VB cord-346964-9afuen7k 104 7 in in IN cord-346964-9afuen7k 104 8 infants infant NNS cord-346964-9afuen7k 104 9 , , , cord-346964-9afuen7k 104 10 while while IN cord-346964-9afuen7k 104 11 secondary secondary JJ cord-346964-9afuen7k 104 12 deficiency deficiency NN cord-346964-9afuen7k 104 13 may may MD cord-346964-9afuen7k 104 14 result result VB cord-346964-9afuen7k 104 15 from from IN cord-346964-9afuen7k 104 16 disorders disorder NNS cord-346964-9afuen7k 104 17 causing cause VBG cord-346964-9afuen7k 104 18 mucosal mucosal JJ cord-346964-9afuen7k 104 19 injury injury NN cord-346964-9afuen7k 104 20 including include VBG cord-346964-9afuen7k 104 21 celiac celiac NNP cord-346964-9afuen7k 104 22 disease disease NN cord-346964-9afuen7k 104 23 , , , cord-346964-9afuen7k 104 24 tropical tropical JJ cord-346964-9afuen7k 104 25 sprue sprue NN cord-346964-9afuen7k 104 26 , , , cord-346964-9afuen7k 104 27 and and CC cord-346964-9afuen7k 104 28 inflammatory inflammatory JJ cord-346964-9afuen7k 104 29 bowel bowel NN cord-346964-9afuen7k 104 30 disease disease NN cord-346964-9afuen7k 104 31 ( ( -LRB- cord-346964-9afuen7k 104 32 IBD IBD NNP cord-346964-9afuen7k 104 33 ) ) -RRB- cord-346964-9afuen7k 104 34 . . . cord-346964-9afuen7k 105 1 Intermittent intermittent JJ cord-346964-9afuen7k 105 2 distribution distribution NN cord-346964-9afuen7k 105 3 of of IN cord-346964-9afuen7k 105 4 lactase lactase NN cord-346964-9afuen7k 105 5 on on IN cord-346964-9afuen7k 105 6 the the DT cord-346964-9afuen7k 105 7 brush brush NN cord-346964-9afuen7k 105 8 border border NN cord-346964-9afuen7k 105 9 is be VBZ cord-346964-9afuen7k 105 10 revealed reveal VBN cord-346964-9afuen7k 105 11 by by IN cord-346964-9afuen7k 105 12 immunohistochemistry immunohistochemistry NN cord-346964-9afuen7k 105 13 , , , cord-346964-9afuen7k 105 14 hydrogen hydrogen NN cord-346964-9afuen7k 105 15 breath breath NN cord-346964-9afuen7k 105 16 tests test NNS cord-346964-9afuen7k 105 17 and and CC cord-346964-9afuen7k 105 18 response response NN cord-346964-9afuen7k 105 19 to to IN cord-346964-9afuen7k 105 20 an an DT cord-346964-9afuen7k 105 21 exclusion exclusion NN cord-346964-9afuen7k 105 22 diet diet NN cord-346964-9afuen7k 105 23 are be VBP cord-346964-9afuen7k 105 24 the the DT cord-346964-9afuen7k 105 25 diagnostic diagnostic JJ cord-346964-9afuen7k 105 26 procedures procedure NNS cord-346964-9afuen7k 105 27 for for IN cord-346964-9afuen7k 105 28 lactase lactase NN cord-346964-9afuen7k 105 29 deficiency deficiency NN cord-346964-9afuen7k 105 30 . . . cord-346964-9afuen7k 106 1 Conditions condition NNS cord-346964-9afuen7k 106 2 leading lead VBG cord-346964-9afuen7k 106 3 to to IN cord-346964-9afuen7k 106 4 a a DT cord-346964-9afuen7k 106 5 decrease decrease NN cord-346964-9afuen7k 106 6 in in IN cord-346964-9afuen7k 106 7 surface surface NN cord-346964-9afuen7k 106 8 area area NN cord-346964-9afuen7k 106 9 of of IN cord-346964-9afuen7k 106 10 the the DT cord-346964-9afuen7k 106 11 small small JJ cord-346964-9afuen7k 106 12 intestine intestine NN cord-346964-9afuen7k 106 13 are be VBP cord-346964-9afuen7k 106 14 among among IN cord-346964-9afuen7k 106 15 the the DT cord-346964-9afuen7k 106 16 leading lead VBG cord-346964-9afuen7k 106 17 causes cause NNS cord-346964-9afuen7k 106 18 of of IN cord-346964-9afuen7k 106 19 malabsorption malabsorption NN cord-346964-9afuen7k 106 20 as as IN cord-346964-9afuen7k 106 21 they -PRON- PRP cord-346964-9afuen7k 106 22 also also RB cord-346964-9afuen7k 106 23 cause cause VBP cord-346964-9afuen7k 106 24 shortened shorten VBN cord-346964-9afuen7k 106 25 transit transit NN cord-346964-9afuen7k 106 26 time time NN cord-346964-9afuen7k 106 27 and and CC cord-346964-9afuen7k 106 28 defective defective JJ cord-346964-9afuen7k 106 29 exposure exposure NN cord-346964-9afuen7k 106 30 to to IN cord-346964-9afuen7k 106 31 digestive digestive JJ cord-346964-9afuen7k 106 32 enzymes enzyme NNS cord-346964-9afuen7k 106 33 . . . cord-346964-9afuen7k 107 1 This this DT cord-346964-9afuen7k 107 2 may may MD cord-346964-9afuen7k 107 3 be be VB cord-346964-9afuen7k 107 4 in in IN cord-346964-9afuen7k 107 5 the the DT cord-346964-9afuen7k 107 6 form form NN cord-346964-9afuen7k 107 7 of of IN cord-346964-9afuen7k 107 8 either either CC cord-346964-9afuen7k 107 9 decreased decrease VBN cord-346964-9afuen7k 107 10 intestinal intestinal JJ cord-346964-9afuen7k 107 11 mucosal mucosal NN cord-346964-9afuen7k 107 12 mass mass NN cord-346964-9afuen7k 107 13 as as IN cord-346964-9afuen7k 107 14 in in IN cord-346964-9afuen7k 107 15 surgically surgically RB cord-346964-9afuen7k 107 16 resected resect VBN cord-346964-9afuen7k 107 17 small small JJ cord-346964-9afuen7k 107 18 bowel bowel NN cord-346964-9afuen7k 107 19 or or CC cord-346964-9afuen7k 107 20 short short JJ cord-346964-9afuen7k 107 21 bowel bowel NN cord-346964-9afuen7k 107 22 syndrome syndrome NN cord-346964-9afuen7k 107 23 or or CC cord-346964-9afuen7k 107 24 may may MD cord-346964-9afuen7k 107 25 result result VB cord-346964-9afuen7k 107 26 from from IN cord-346964-9afuen7k 107 27 functional functional JJ cord-346964-9afuen7k 107 28 loss loss NN cord-346964-9afuen7k 107 29 of of IN cord-346964-9afuen7k 107 30 the the DT cord-346964-9afuen7k 107 31 mucosa mucosa NN cord-346964-9afuen7k 107 32 as as IN cord-346964-9afuen7k 107 33 in in IN cord-346964-9afuen7k 107 34 CD CD NNP cord-346964-9afuen7k 107 35 , , , cord-346964-9afuen7k 107 36 tropical tropical JJ cord-346964-9afuen7k 107 37 sprue sprue NN cord-346964-9afuen7k 107 38 , , , cord-346964-9afuen7k 107 39 autoimmune autoimmune JJ cord-346964-9afuen7k 107 40 enteropathy enteropathy NNP cord-346964-9afuen7k 107 41 , , , cord-346964-9afuen7k 107 42 and and CC cord-346964-9afuen7k 107 43 intestinal intestinal JJ cord-346964-9afuen7k 107 44 lymphangiectasia lymphangiectasia NNS cord-346964-9afuen7k 107 45 . . . cord-346964-9afuen7k 108 1 Celiac Celiac NNP cord-346964-9afuen7k 108 2 Disease Disease NNP cord-346964-9afuen7k 108 3 : : : cord-346964-9afuen7k 108 4 CD CD NNP cord-346964-9afuen7k 108 5 , , , cord-346964-9afuen7k 108 6 also also RB cord-346964-9afuen7k 108 7 known know VBN cord-346964-9afuen7k 108 8 as as IN cord-346964-9afuen7k 108 9 celiac celiac JJ cord-346964-9afuen7k 108 10 sprue sprue NN cord-346964-9afuen7k 108 11 , , , cord-346964-9afuen7k 108 12 nontropical nontropical JJ cord-346964-9afuen7k 108 13 sprue sprue NN cord-346964-9afuen7k 108 14 , , , cord-346964-9afuen7k 108 15 gluten gluten NN cord-346964-9afuen7k 108 16 - - HYPH cord-346964-9afuen7k 108 17 induced induce VBN cord-346964-9afuen7k 108 18 enteropathy enteropathy NNP cord-346964-9afuen7k 108 19 , , , cord-346964-9afuen7k 108 20 or or CC cord-346964-9afuen7k 108 21 gluten gluten NN cord-346964-9afuen7k 108 22 - - HYPH cord-346964-9afuen7k 108 23 sensitive sensitive JJ cord-346964-9afuen7k 108 24 enteropathy enteropathy NNS cord-346964-9afuen7k 108 25 ( ( -LRB- cord-346964-9afuen7k 108 26 GSE GSE NNP cord-346964-9afuen7k 108 27 ) ) -RRB- cord-346964-9afuen7k 108 28 , , , cord-346964-9afuen7k 108 29 is be VBZ cord-346964-9afuen7k 108 30 a a DT cord-346964-9afuen7k 108 31 chronic chronic JJ cord-346964-9afuen7k 108 32 inflammatory inflammatory JJ cord-346964-9afuen7k 108 33 disorder disorder NN cord-346964-9afuen7k 108 34 of of IN cord-346964-9afuen7k 108 35 the the DT cord-346964-9afuen7k 108 36 small small JJ cord-346964-9afuen7k 108 37 intestine intestine NN cord-346964-9afuen7k 108 38 characterized characterize VBN cord-346964-9afuen7k 108 39 by by IN cord-346964-9afuen7k 108 40 malabsorption malabsorption NN cord-346964-9afuen7k 108 41 after after IN cord-346964-9afuen7k 108 42 ingestion ingestion NN cord-346964-9afuen7k 108 43 of of IN cord-346964-9afuen7k 108 44 wheat wheat NN cord-346964-9afuen7k 108 45 gluten gluten NN cord-346964-9afuen7k 108 46 or or CC cord-346964-9afuen7k 108 47 related related JJ cord-346964-9afuen7k 108 48 proteins protein NNS cord-346964-9afuen7k 108 49 in in IN cord-346964-9afuen7k 108 50 rye rye NN cord-346964-9afuen7k 108 51 ( ( -LRB- cord-346964-9afuen7k 108 52 secalins secalins NNP cord-346964-9afuen7k 108 53 ) ) -RRB- cord-346964-9afuen7k 108 54 and and CC cord-346964-9afuen7k 108 55 barley barley NN cord-346964-9afuen7k 108 56 ( ( -LRB- cord-346964-9afuen7k 108 57 hordeins hordeins NNP cord-346964-9afuen7k 108 58 ) ) -RRB- cord-346964-9afuen7k 108 59 in in IN cord-346964-9afuen7k 108 60 individuals individual NNS cord-346964-9afuen7k 108 61 with with IN cord-346964-9afuen7k 108 62 a a DT cord-346964-9afuen7k 108 63 certain certain JJ cord-346964-9afuen7k 108 64 genetic genetic JJ cord-346964-9afuen7k 108 65 background background NN cord-346964-9afuen7k 108 66 . . . cord-346964-9afuen7k 109 1 The the DT cord-346964-9afuen7k 109 2 pathogenesis pathogenesis NN cord-346964-9afuen7k 109 3 involves involve VBZ cord-346964-9afuen7k 109 4 a a DT cord-346964-9afuen7k 109 5 T t NN cord-346964-9afuen7k 109 6 - - HYPH cord-346964-9afuen7k 109 7 cell cell NN cord-346964-9afuen7k 109 8 - - HYPH cord-346964-9afuen7k 109 9 mediated mediate VBN cord-346964-9afuen7k 109 10 immune immune JJ cord-346964-9afuen7k 109 11 response response NN cord-346964-9afuen7k 109 12 and and CC cord-346964-9afuen7k 109 13 autoreactive autoreactive JJ cord-346964-9afuen7k 109 14 B b NN cord-346964-9afuen7k 109 15 lymphocytes lymphocyte NNS cord-346964-9afuen7k 109 16 that that WDT cord-346964-9afuen7k 109 17 produce produce VBP cord-346964-9afuen7k 109 18 autoantibodies autoantibody NNS cord-346964-9afuen7k 109 19 directed direct VBN cord-346964-9afuen7k 109 20 against against IN cord-346964-9afuen7k 109 21 gliadin gliadin NN cord-346964-9afuen7k 109 22 , , , cord-346964-9afuen7k 109 23 endomysium endomysium NN cord-346964-9afuen7k 109 24 , , , cord-346964-9afuen7k 109 25 or or CC cord-346964-9afuen7k 109 26 tissue tissue NN cord-346964-9afuen7k 109 27 transglutaminase transglutaminase NN cord-346964-9afuen7k 109 28 ( ( -LRB- cord-346964-9afuen7k 109 29 tTG tTG NNP cord-346964-9afuen7k 109 30 ) ) -RRB- cord-346964-9afuen7k 109 31 in in IN cord-346964-9afuen7k 109 32 individuals individual NNS cord-346964-9afuen7k 109 33 with with IN cord-346964-9afuen7k 109 34 a a DT cord-346964-9afuen7k 109 35 genetic genetic JJ cord-346964-9afuen7k 109 36 susceptibility susceptibility NN cord-346964-9afuen7k 109 37 related relate VBN cord-346964-9afuen7k 109 38 to to IN cord-346964-9afuen7k 109 39 human human JJ cord-346964-9afuen7k 109 40 leukocyte leukocyte NN cord-346964-9afuen7k 109 41 antigen antigen NN cord-346964-9afuen7k 109 42 ( ( -LRB- cord-346964-9afuen7k 109 43 HLA)-DQ2 HLA)-DQ2 NNP cord-346964-9afuen7k 109 44 and and CC cord-346964-9afuen7k 109 45 HLA HLA NNP cord-346964-9afuen7k 109 46 - - HYPH cord-346964-9afuen7k 109 47 DQ8 DQ8 NNP cord-346964-9afuen7k 109 48 . . . cord-346964-9afuen7k 110 1 The the DT cord-346964-9afuen7k 110 2 mechanism(s mechanism(s NNP cord-346964-9afuen7k 110 3 ) ) -RRB- cord-346964-9afuen7k 111 1 by by IN cord-346964-9afuen7k 111 2 which which WDT cord-346964-9afuen7k 111 3 gluten gluten NN cord-346964-9afuen7k 111 4 injures injure VBZ cord-346964-9afuen7k 111 5 the the DT cord-346964-9afuen7k 111 6 epithelium epithelium NN cord-346964-9afuen7k 111 7 has have VBZ cord-346964-9afuen7k 111 8 not not RB cord-346964-9afuen7k 111 9 been be VBN cord-346964-9afuen7k 111 10 fully fully RB cord-346964-9afuen7k 111 11 established establish VBN cord-346964-9afuen7k 111 12 . . . cord-346964-9afuen7k 112 1 However however RB cord-346964-9afuen7k 112 2 , , , cord-346964-9afuen7k 112 3 immunologic immunologic JJ cord-346964-9afuen7k 112 4 , , , cord-346964-9afuen7k 112 5 genetic genetic JJ cord-346964-9afuen7k 112 6 , , , cord-346964-9afuen7k 112 7 and and CC cord-346964-9afuen7k 112 8 environmental environmental JJ cord-346964-9afuen7k 112 9 factors factor NNS cord-346964-9afuen7k 112 10 all all DT cord-346964-9afuen7k 112 11 seem seem VBP cord-346964-9afuen7k 112 12 to to TO cord-346964-9afuen7k 112 13 be be VB cord-346964-9afuen7k 112 14 important important JJ cord-346964-9afuen7k 112 15 . . . cord-346964-9afuen7k 113 1 Figure figure NN cord-346964-9afuen7k 113 2 2 2 CD cord-346964-9afuen7k 113 3 Mechanisms mechanism NNS cord-346964-9afuen7k 113 4 of of IN cord-346964-9afuen7k 113 5 malabsorption malabsorption NN cord-346964-9afuen7k 113 6 with with IN cord-346964-9afuen7k 113 7 respect respect NN cord-346964-9afuen7k 113 8 to to IN cord-346964-9afuen7k 113 9 luminal luminal JJ cord-346964-9afuen7k 113 10 , , , cord-346964-9afuen7k 113 11 mucosal mucosal JJ cord-346964-9afuen7k 113 12 , , , cord-346964-9afuen7k 113 13 and and CC cord-346964-9afuen7k 113 14 mural mural NN cord-346964-9afuen7k 113 15 / / SYM cord-346964-9afuen7k 113 16 transport transport NN cord-346964-9afuen7k 113 17 phases phase NNS cord-346964-9afuen7k 113 18 . . . cord-346964-9afuen7k 114 1 a. a. NN cord-346964-9afuen7k 114 2 Immune Immune NNP cord-346964-9afuen7k 114 3 mechanisms mechanism NNS cord-346964-9afuen7k 114 4 . . . cord-346964-9afuen7k 115 1 Multiple multiple JJ cord-346964-9afuen7k 115 2 observations observation NNS cord-346964-9afuen7k 115 3 favor favor VBP cord-346964-9afuen7k 115 4 the the DT cord-346964-9afuen7k 115 5 conclusion conclusion NN cord-346964-9afuen7k 115 6 that that IN cord-346964-9afuen7k 115 7 celiac celiac JJ cord-346964-9afuen7k 115 8 disease disease NN cord-346964-9afuen7k 115 9 is be VBZ cord-346964-9afuen7k 115 10 an an DT cord-346964-9afuen7k 115 11 autoimmune autoimmune JJ cord-346964-9afuen7k 115 12 disorder disorder NN cord-346964-9afuen7k 115 13 occurring occur VBG cord-346964-9afuen7k 115 14 in in IN cord-346964-9afuen7k 115 15 the the DT cord-346964-9afuen7k 115 16 context context NN cord-346964-9afuen7k 115 17 of of IN cord-346964-9afuen7k 115 18 a a DT cord-346964-9afuen7k 115 19 combination combination NN cord-346964-9afuen7k 115 20 of of IN cord-346964-9afuen7k 115 21 genetic genetic JJ cord-346964-9afuen7k 115 22 and and CC cord-346964-9afuen7k 115 23 environmental environmental JJ cord-346964-9afuen7k 115 24 factors factor NNS cord-346964-9afuen7k 115 25 , , , cord-346964-9afuen7k 115 26 including include VBG cord-346964-9afuen7k 115 27 the the DT cord-346964-9afuen7k 115 28 following follow VBG cord-346964-9afuen7k 115 29 : : : cord-346964-9afuen7k 115 30 i. i. NNP cord-346964-9afuen7k 115 31 Serum serum NN cord-346964-9afuen7k 115 32 antibodies antibody NNS cord-346964-9afuen7k 115 33 to to IN cord-346964-9afuen7k 115 34 gluten gluten NN cord-346964-9afuen7k 115 35 and and CC cord-346964-9afuen7k 115 36 its -PRON- PRP$ cord-346964-9afuen7k 115 37 gliadin gliadin NN cord-346964-9afuen7k 115 38 fraction fraction NN cord-346964-9afuen7k 115 39 are be VBP cord-346964-9afuen7k 115 40 virtually virtually RB cord-346964-9afuen7k 115 41 always always RB cord-346964-9afuen7k 115 42 present present JJ cord-346964-9afuen7k 115 43 in in IN cord-346964-9afuen7k 115 44 active active JJ cord-346964-9afuen7k 115 45 celiac celiac JJ cord-346964-9afuen7k 115 46 disease disease NN cord-346964-9afuen7k 115 47 . . . cord-346964-9afuen7k 116 1 A a DT cord-346964-9afuen7k 116 2 recent recent JJ cord-346964-9afuen7k 116 3 study study NN cord-346964-9afuen7k 116 4 showed show VBD cord-346964-9afuen7k 116 5 subepithelial subepithelial JJ cord-346964-9afuen7k 116 6 deposition deposition NN cord-346964-9afuen7k 116 7 of of IN cord-346964-9afuen7k 116 8 activated activate VBN cord-346964-9afuen7k 116 9 complement complement NN cord-346964-9afuen7k 116 10 IgG IgG NNP cord-346964-9afuen7k 116 11 and and CC cord-346964-9afuen7k 116 12 IgM IgM NNP cord-346964-9afuen7k 116 13 in in IN cord-346964-9afuen7k 116 14 proportion proportion NN cord-346964-9afuen7k 116 15 to to IN cord-346964-9afuen7k 116 16 circulating circulate VBG cord-346964-9afuen7k 116 17 antigliadin antigliadin NNS cord-346964-9afuen7k 116 18 levels level NNS cord-346964-9afuen7k 116 19 , , , cord-346964-9afuen7k 116 20 suggesting suggest VBG cord-346964-9afuen7k 116 21 humoral humoral JJ cord-346964-9afuen7k 116 22 epithelial epithelial JJ cord-346964-9afuen7k 116 23 injury injury NN cord-346964-9afuen7k 116 24 . . . cord-346964-9afuen7k 117 1 Antireticulin antireticulin JJ cord-346964-9afuen7k 117 2 antibodies antibody NNS cord-346964-9afuen7k 117 3 , , , cord-346964-9afuen7k 117 4 antiendomysium antiendomysium NN cord-346964-9afuen7k 117 5 antibodies antibody NNS cord-346964-9afuen7k 117 6 , , , cord-346964-9afuen7k 117 7 and and CC cord-346964-9afuen7k 117 8 anti anti JJ cord-346964-9afuen7k 117 9 - - JJ cord-346964-9afuen7k 117 10 tTG ttg JJ cord-346964-9afuen7k 117 11 antibodies antibody NNS cord-346964-9afuen7k 117 12 also also RB cord-346964-9afuen7k 117 13 correlate correlate VBP cord-346964-9afuen7k 117 14 with with IN cord-346964-9afuen7k 117 15 disease disease NN cord-346964-9afuen7k 117 16 activity activity NN cord-346964-9afuen7k 117 17 and and CC cord-346964-9afuen7k 117 18 have have VBP cord-346964-9afuen7k 117 19 diagnostic diagnostic JJ cord-346964-9afuen7k 117 20 specificity specificity NN cord-346964-9afuen7k 117 21 . . . cord-346964-9afuen7k 118 1 ii ii NNP cord-346964-9afuen7k 118 2 . . . cord-346964-9afuen7k 119 1 There there EX cord-346964-9afuen7k 119 2 is be VBZ cord-346964-9afuen7k 119 3 presence presence NN cord-346964-9afuen7k 119 4 of of IN cord-346964-9afuen7k 119 5 numerous numerous JJ cord-346964-9afuen7k 119 6 intraepithelial intraepithelial JJ cord-346964-9afuen7k 119 7 lymphocytes lymphocyte NNS cord-346964-9afuen7k 119 8 ( ( -LRB- cord-346964-9afuen7k 119 9 IELs iel NNS cord-346964-9afuen7k 119 10 ) ) -RRB- cord-346964-9afuen7k 119 11 , , , cord-346964-9afuen7k 119 12 chiefly chiefly RB cord-346964-9afuen7k 119 13 in in IN cord-346964-9afuen7k 119 14 the the DT cord-346964-9afuen7k 119 15 injured injure VBN cord-346964-9afuen7k 119 16 surface surface NN cord-346964-9afuen7k 119 17 epithelium epithelium NN cord-346964-9afuen7k 119 18 ( ( -LRB- cord-346964-9afuen7k 119 19 these these DT cord-346964-9afuen7k 119 20 are be VBP cord-346964-9afuen7k 119 21 mostly mostly RB cord-346964-9afuen7k 119 22 T t NN cord-346964-9afuen7k 119 23 cells cell NNS cord-346964-9afuen7k 119 24 , , , cord-346964-9afuen7k 119 25 but but CC cord-346964-9afuen7k 119 26 with with IN cord-346964-9afuen7k 119 27 a a DT cord-346964-9afuen7k 119 28 high high JJ cord-346964-9afuen7k 119 29 proportion proportion NN cord-346964-9afuen7k 119 30 gamma gamma NN cord-346964-9afuen7k 119 31 / / SYM cord-346964-9afuen7k 119 32 delta delta NN cord-346964-9afuen7k 119 33 types type NNS cord-346964-9afuen7k 119 34 ) ) -RRB- cord-346964-9afuen7k 119 35 . . . cord-346964-9afuen7k 120 1 This this DT cord-346964-9afuen7k 120 2 is be VBZ cord-346964-9afuen7k 120 3 highly highly RB cord-346964-9afuen7k 120 4 consistent consistent JJ cord-346964-9afuen7k 120 5 with with IN cord-346964-9afuen7k 120 6 cellmediated cellmediate VBN cord-346964-9afuen7k 120 7 injury injury NN cord-346964-9afuen7k 120 8 that that WDT cord-346964-9afuen7k 120 9 is be VBZ cord-346964-9afuen7k 120 10 somehow somehow RB cord-346964-9afuen7k 120 11 facilitated facilitate VBN cord-346964-9afuen7k 120 12 by by IN cord-346964-9afuen7k 120 13 gluten gluten NN cord-346964-9afuen7k 120 14 . . . cord-346964-9afuen7k 121 1 iii iii NNP cord-346964-9afuen7k 121 2 . . . cord-346964-9afuen7k 122 1 Steroids steroid NNS cord-346964-9afuen7k 122 2 can can MD cord-346964-9afuen7k 122 3 cause cause VB cord-346964-9afuen7k 122 4 patient patient JJ cord-346964-9afuen7k 122 5 improvement improvement NN cord-346964-9afuen7k 122 6 comparable comparable JJ cord-346964-9afuen7k 122 7 to to IN cord-346964-9afuen7k 122 8 that that DT cord-346964-9afuen7k 122 9 with with IN cord-346964-9afuen7k 122 10 a a DT cord-346964-9afuen7k 122 11 gluten gluten NN cord-346964-9afuen7k 122 12 - - HYPH cord-346964-9afuen7k 122 13 free free JJ cord-346964-9afuen7k 122 14 diet diet NN cord-346964-9afuen7k 122 15 ( ( -LRB- cord-346964-9afuen7k 122 16 GFD GFD NNP cord-346964-9afuen7k 122 17 ) ) -RRB- cord-346964-9afuen7k 122 18 . . . cord-346964-9afuen7k 123 1 iv iv LS cord-346964-9afuen7k 123 2 . . . cord-346964-9afuen7k 124 1 Patients patient NNS cord-346964-9afuen7k 124 2 with with IN cord-346964-9afuen7k 124 3 celiac celiac JJ cord-346964-9afuen7k 124 4 diseases disease NNS cord-346964-9afuen7k 124 5 show show VBP cord-346964-9afuen7k 124 6 a a DT cord-346964-9afuen7k 124 7 highly highly RB cord-346964-9afuen7k 124 8 significant significant JJ cord-346964-9afuen7k 124 9 excess excess NN cord-346964-9afuen7k 124 10 of of IN cord-346964-9afuen7k 124 11 other other JJ cord-346964-9afuen7k 124 12 autoimmune autoimmune JJ cord-346964-9afuen7k 124 13 diseases disease NNS cord-346964-9afuen7k 124 14 ( ( -LRB- cord-346964-9afuen7k 124 15 e.g. e.g. RB cord-346964-9afuen7k 124 16 , , , cord-346964-9afuen7k 124 17 insulindependent insulindependent NN cord-346964-9afuen7k 124 18 diabetes diabetes NN cord-346964-9afuen7k 124 19 mellitus mellitus NN cord-346964-9afuen7k 124 20 ) ) -RRB- cord-346964-9afuen7k 124 21 . . . cord-346964-9afuen7k 125 1 b. b. NNP cord-346964-9afuen7k 125 2 Genetic genetic JJ cord-346964-9afuen7k 125 3 factors factor NNS cord-346964-9afuen7k 125 4 . . . cord-346964-9afuen7k 126 1 Genetic genetic JJ cord-346964-9afuen7k 126 2 factors factor NNS cord-346964-9afuen7k 126 3 include include VBP cord-346964-9afuen7k 126 4 the the DT cord-346964-9afuen7k 126 5 following follow VBG cord-346964-9afuen7k 126 6 : : : cord-346964-9afuen7k 127 1 i. i. LS cord-346964-9afuen7k 127 2 There there EX cord-346964-9afuen7k 127 3 are be VBP cord-346964-9afuen7k 127 4 a a DT cord-346964-9afuen7k 127 5 strong strong JJ cord-346964-9afuen7k 127 6 tendency tendency NN cord-346964-9afuen7k 127 7 for for IN cord-346964-9afuen7k 127 8 celiac celiac JJ cord-346964-9afuen7k 127 9 disease disease NN cord-346964-9afuen7k 127 10 to to TO cord-346964-9afuen7k 127 11 run run VB cord-346964-9afuen7k 127 12 in in IN cord-346964-9afuen7k 127 13 families family NNS cord-346964-9afuen7k 127 14 ( ( -LRB- cord-346964-9afuen7k 127 15 11 11 CD cord-346964-9afuen7k 127 16 - - SYM cord-346964-9afuen7k 127 17 22 22 CD cord-346964-9afuen7k 127 18 % % NN cord-346964-9afuen7k 127 19 occurrence occurrence NN cord-346964-9afuen7k 127 20 in in IN cord-346964-9afuen7k 127 21 first first JJ cord-346964-9afuen7k 127 22 degree degree NN cord-346964-9afuen7k 127 23 relatives relative NNS cord-346964-9afuen7k 127 24 ) ) -RRB- cord-346964-9afuen7k 127 25 and and CC cord-346964-9afuen7k 127 26 also also RB cord-346964-9afuen7k 127 27 a a DT cord-346964-9afuen7k 127 28 high high JJ cord-346964-9afuen7k 127 29 ( ( -LRB- cord-346964-9afuen7k 127 30 70 70 CD cord-346964-9afuen7k 127 31 % % NN cord-346964-9afuen7k 127 32 ) ) -RRB- cord-346964-9afuen7k 127 33 concordance concordance NN cord-346964-9afuen7k 127 34 for for IN cord-346964-9afuen7k 127 35 celiac celiac JJ cord-346964-9afuen7k 127 36 diseases disease NNS cord-346964-9afuen7k 127 37 in in IN cord-346964-9afuen7k 127 38 identical identical JJ cord-346964-9afuen7k 127 39 twin twin JJ cord-346964-9afuen7k 127 40 pairs pair NNS cord-346964-9afuen7k 127 41 . . . cord-346964-9afuen7k 128 1 ii ii NNP cord-346964-9afuen7k 128 2 . . . cord-346964-9afuen7k 129 1 There there EX cord-346964-9afuen7k 129 2 is be VBZ cord-346964-9afuen7k 129 3 a a DT cord-346964-9afuen7k 129 4 high high JJ cord-346964-9afuen7k 129 5 correlation correlation NN cord-346964-9afuen7k 129 6 between between IN cord-346964-9afuen7k 129 7 celiac celiac JJ cord-346964-9afuen7k 129 8 disease disease NN cord-346964-9afuen7k 129 9 and and CC cord-346964-9afuen7k 129 10 presence presence NN cord-346964-9afuen7k 129 11 of of IN cord-346964-9afuen7k 129 12 HLA HLA NNP cord-346964-9afuen7k 129 13 - - HYPH cord-346964-9afuen7k 129 14 B8 B8 NNP cord-346964-9afuen7k 129 15 , , , cord-346964-9afuen7k 129 16 DR3(DR17 DR3(DR17 NNP cord-346964-9afuen7k 129 17 ) ) -RRB- cord-346964-9afuen7k 129 18 , , , cord-346964-9afuen7k 129 19 DR7 dr7 NN cord-346964-9afuen7k 129 20 , , , cord-346964-9afuen7k 129 21 and and CC cord-346964-9afuen7k 129 22 DQ2 dq2 NN cord-346964-9afuen7k 129 23 histocompatibility histocompatibility NN cord-346964-9afuen7k 129 24 loci locus NNS cord-346964-9afuen7k 129 25 . . . cord-346964-9afuen7k 130 1 The the DT cord-346964-9afuen7k 130 2 strongest strong JJS cord-346964-9afuen7k 130 3 association association NN cord-346964-9afuen7k 130 4 ( ( -LRB- cord-346964-9afuen7k 130 5 95 95 CD cord-346964-9afuen7k 130 6 % % NN cord-346964-9afuen7k 130 7 ) ) -RRB- cord-346964-9afuen7k 130 8 is be VBZ cord-346964-9afuen7k 130 9 with with IN cord-346964-9afuen7k 130 10 a a DT cord-346964-9afuen7k 130 11 specific specific JJ cord-346964-9afuen7k 130 12 HLA HLA NNP cord-346964-9afuen7k 130 13 DQ2 dq2 NN cord-346964-9afuen7k 130 14 molecule molecule NN cord-346964-9afuen7k 130 15 that that WDT cord-346964-9afuen7k 130 16 is be VBZ cord-346964-9afuen7k 130 17 seen see VBN cord-346964-9afuen7k 130 18 in in IN cord-346964-9afuen7k 130 19 only only RB cord-346964-9afuen7k 130 20 20 20 CD cord-346964-9afuen7k 130 21 - - SYM cord-346964-9afuen7k 130 22 30 30 CD cord-346964-9afuen7k 130 23 % % NN cord-346964-9afuen7k 130 24 of of IN cord-346964-9afuen7k 130 25 the the DT cord-346964-9afuen7k 130 26 general general JJ cord-346964-9afuen7k 130 27 population population NN cord-346964-9afuen7k 130 28 . . . cord-346964-9afuen7k 131 1 The the DT cord-346964-9afuen7k 131 2 genetics genetic NNS cord-346964-9afuen7k 131 3 seem seem VBP cord-346964-9afuen7k 131 4 to to TO cord-346964-9afuen7k 131 5 be be VB cord-346964-9afuen7k 131 6 ' ' `` cord-346964-9afuen7k 131 7 complex complex JJ cord-346964-9afuen7k 131 8 ' ' '' cord-346964-9afuen7k 131 9 and and CC cord-346964-9afuen7k 131 10 a a DT cord-346964-9afuen7k 131 11 multigenic multigenic JJ cord-346964-9afuen7k 131 12 HLA HLA NNP cord-346964-9afuen7k 131 13 - - HYPH cord-346964-9afuen7k 131 14 associated associate VBN cord-346964-9afuen7k 131 15 susceptibility susceptibility NN cord-346964-9afuen7k 131 16 is be VBZ cord-346964-9afuen7k 131 17 favored favor VBN cord-346964-9afuen7k 131 18 . . . cord-346964-9afuen7k 132 1 iii iii NNP cord-346964-9afuen7k 132 2 . . . cord-346964-9afuen7k 133 1 There there EX cord-346964-9afuen7k 133 2 are be VBP cord-346964-9afuen7k 133 3 overlap overlap VBP cord-346964-9afuen7k 133 4 with with IN cord-346964-9afuen7k 133 5 the the DT cord-346964-9afuen7k 133 6 blistering blistering JJ cord-346964-9afuen7k 133 7 skin skin NN cord-346964-9afuen7k 133 8 condition condition NN cord-346964-9afuen7k 133 9 dermatitis dermatitis NN cord-346964-9afuen7k 133 10 herpetiformis herpetiformis NNP cord-346964-9afuen7k 133 11 , , , cord-346964-9afuen7k 133 12 including include VBG cord-346964-9afuen7k 133 13 similar similar JJ cord-346964-9afuen7k 133 14 mucosal mucosal JJ cord-346964-9afuen7k 133 15 alterations alteration NNS cord-346964-9afuen7k 133 16 , , , cord-346964-9afuen7k 133 17 and and CC cord-346964-9afuen7k 133 18 overlap overlap VBP cord-346964-9afuen7k 133 19 in in IN cord-346964-9afuen7k 133 20 HLA HLA NNP cord-346964-9afuen7k 133 21 markers marker NNS cord-346964-9afuen7k 133 22 and and CC cord-346964-9afuen7k 133 23 improvement improvement NN cord-346964-9afuen7k 133 24 in in IN cord-346964-9afuen7k 133 25 the the DT cord-346964-9afuen7k 133 26 skin skin NN cord-346964-9afuen7k 133 27 lesions lesion NNS cord-346964-9afuen7k 133 28 on on IN cord-346964-9afuen7k 133 29 a a DT cord-346964-9afuen7k 133 30 GFD gfd NN cord-346964-9afuen7k 133 31 . . . cord-346964-9afuen7k 134 1 c. c. NNP cord-346964-9afuen7k 134 2 Environmental Environmental NNP cord-346964-9afuen7k 134 3 factor(s factor(s NNP cord-346964-9afuen7k 134 4 ) ) -RRB- cord-346964-9afuen7k 134 5 . . . cord-346964-9afuen7k 135 1 It -PRON- PRP cord-346964-9afuen7k 135 2 seems seem VBZ cord-346964-9afuen7k 135 3 likely likely JJ cord-346964-9afuen7k 135 4 that that IN cord-346964-9afuen7k 135 5 an an DT cord-346964-9afuen7k 135 6 environmental environmental JJ cord-346964-9afuen7k 135 7 factor factor NN cord-346964-9afuen7k 135 8 is be VBZ cord-346964-9afuen7k 135 9 a a DT cord-346964-9afuen7k 135 10 necessary necessary JJ cord-346964-9afuen7k 135 11 precondition precondition NN cord-346964-9afuen7k 135 12 , , , cord-346964-9afuen7k 135 13 along along IN cord-346964-9afuen7k 135 14 with with IN cord-346964-9afuen7k 135 15 appropriate appropriate JJ cord-346964-9afuen7k 135 16 genetic genetic JJ cord-346964-9afuen7k 135 17 makeup makeup NN cord-346964-9afuen7k 135 18 and and CC cord-346964-9afuen7k 135 19 gluten gluten NN cord-346964-9afuen7k 135 20 ingestion ingestion NN cord-346964-9afuen7k 135 21 , , , cord-346964-9afuen7k 135 22 for for IN cord-346964-9afuen7k 135 23 an an DT cord-346964-9afuen7k 135 24 individual individual NN cord-346964-9afuen7k 135 25 to to TO cord-346964-9afuen7k 135 26 develop develop VB cord-346964-9afuen7k 135 27 celiac celiac JJ cord-346964-9afuen7k 135 28 disease disease NN cord-346964-9afuen7k 135 29 . . . cord-346964-9afuen7k 136 1 Support support NN cord-346964-9afuen7k 136 2 for for IN cord-346964-9afuen7k 136 3 this this DT cord-346964-9afuen7k 136 4 conclusion conclusion NN cord-346964-9afuen7k 136 5 comes come VBZ cord-346964-9afuen7k 136 6 from from IN cord-346964-9afuen7k 136 7 the the DT cord-346964-9afuen7k 136 8 following follow VBG cord-346964-9afuen7k 136 9 : : : cord-346964-9afuen7k 137 1 i. i. NNP cord-346964-9afuen7k 138 1 The the DT cord-346964-9afuen7k 138 2 fact fact NN cord-346964-9afuen7k 138 3 that that IN cord-346964-9afuen7k 138 4 only only RB cord-346964-9afuen7k 138 5 one one CD cord-346964-9afuen7k 138 6 member member NN cord-346964-9afuen7k 138 7 of of IN cord-346964-9afuen7k 138 8 an an DT cord-346964-9afuen7k 138 9 identical identical JJ cord-346964-9afuen7k 138 10 twin twin JJ cord-346964-9afuen7k 138 11 pair pair NN cord-346964-9afuen7k 138 12 is be VBZ cord-346964-9afuen7k 138 13 sometimes sometimes RB cord-346964-9afuen7k 138 14 affected affect VBN cord-346964-9afuen7k 138 15 by by IN cord-346964-9afuen7k 138 16 celiac celiac JJ cord-346964-9afuen7k 138 17 disease disease NN cord-346964-9afuen7k 138 18 . . . cord-346964-9afuen7k 139 1 ii ii NNP cord-346964-9afuen7k 139 2 . . . cord-346964-9afuen7k 140 1 There there EX cord-346964-9afuen7k 140 2 is be VBZ cord-346964-9afuen7k 140 3 evidence evidence NN cord-346964-9afuen7k 140 4 of of IN cord-346964-9afuen7k 140 5 a a DT cord-346964-9afuen7k 140 6 possible possible JJ cord-346964-9afuen7k 140 7 role role NN cord-346964-9afuen7k 140 8 for for IN cord-346964-9afuen7k 140 9 viral viral JJ cord-346964-9afuen7k 140 10 infection infection NN cord-346964-9afuen7k 140 11 : : : cord-346964-9afuen7k 140 12 in in IN cord-346964-9afuen7k 140 13 one one CD cord-346964-9afuen7k 140 14 study study NN cord-346964-9afuen7k 140 15 , , , cord-346964-9afuen7k 140 16 serological serological JJ cord-346964-9afuen7k 140 17 findings finding NNS cord-346964-9afuen7k 140 18 of of IN cord-346964-9afuen7k 140 19 prior prior JJ cord-346964-9afuen7k 140 20 exposure exposure NN cord-346964-9afuen7k 140 21 to to IN cord-346964-9afuen7k 140 22 an an DT cord-346964-9afuen7k 140 23 adenovirus adenovirus NN cord-346964-9afuen7k 140 24 ( ( -LRB- cord-346964-9afuen7k 140 25 type type NN cord-346964-9afuen7k 140 26 12 12 CD cord-346964-9afuen7k 140 27 ) ) -RRB- cord-346964-9afuen7k 140 28 were be VBD cord-346964-9afuen7k 140 29 unusually unusually RB cord-346964-9afuen7k 140 30 common common JJ cord-346964-9afuen7k 140 31 . . . cord-346964-9afuen7k 141 1 In in IN cord-346964-9afuen7k 141 2 addition addition NN cord-346964-9afuen7k 141 3 , , , cord-346964-9afuen7k 141 4 a a DT cord-346964-9afuen7k 141 5 type type NN cord-346964-9afuen7k 141 6 12 12 CD cord-346964-9afuen7k 141 7 adenovirus adenovirus NN cord-346964-9afuen7k 141 8 antigen antigen NN cord-346964-9afuen7k 141 9 shares share VBZ cord-346964-9afuen7k 141 10 an an DT cord-346964-9afuen7k 141 11 amino amino NN cord-346964-9afuen7k 141 12 acid acid NN cord-346964-9afuen7k 141 13 sequence sequence NN cord-346964-9afuen7k 141 14 with with IN cord-346964-9afuen7k 141 15 gliadin gliadin NN cord-346964-9afuen7k 141 16 . . . cord-346964-9afuen7k 142 1 Although although IN cord-346964-9afuen7k 142 2 more more JJR cord-346964-9afuen7k 142 3 recent recent JJ cord-346964-9afuen7k 142 4 studies study NNS cord-346964-9afuen7k 142 5 have have VBP cord-346964-9afuen7k 142 6 not not RB cord-346964-9afuen7k 142 7 confirmed confirm VBN cord-346964-9afuen7k 142 8 a a DT cord-346964-9afuen7k 142 9 direct direct JJ cord-346964-9afuen7k 142 10 correlation correlation NN cord-346964-9afuen7k 142 11 between between IN cord-346964-9afuen7k 142 12 celiac celiac JJ cord-346964-9afuen7k 142 13 diseases disease NNS cord-346964-9afuen7k 142 14 and and CC cord-346964-9afuen7k 142 15 adenovirus adenovirus NN cord-346964-9afuen7k 142 16 12 12 CD cord-346964-9afuen7k 142 17 , , , cord-346964-9afuen7k 142 18 the the DT cord-346964-9afuen7k 142 19 concept concept NN cord-346964-9afuen7k 142 20 remains remain VBZ cord-346964-9afuen7k 142 21 an an DT cord-346964-9afuen7k 142 22 attractive attractive JJ cord-346964-9afuen7k 142 23 paradigm paradigm NN cord-346964-9afuen7k 142 24 . . . cord-346964-9afuen7k 143 1 Mucosal Mucosal NNP cord-346964-9afuen7k 143 2 pathology pathology NN cord-346964-9afuen7k 143 3 in in IN cord-346964-9afuen7k 143 4 CD CD NNP cord-346964-9afuen7k 143 5 may may MD cord-346964-9afuen7k 143 6 be be VB cord-346964-9afuen7k 143 7 summarized summarize VBN cord-346964-9afuen7k 143 8 as as IN cord-346964-9afuen7k 143 9 follows follow VBZ cord-346964-9afuen7k 143 10 : : : cord-346964-9afuen7k 144 1 Following follow VBG cord-346964-9afuen7k 144 2 uptake uptake NN cord-346964-9afuen7k 144 3 of of IN cord-346964-9afuen7k 144 4 gluten gluten NN cord-346964-9afuen7k 144 5 by by IN cord-346964-9afuen7k 144 6 the the DT cord-346964-9afuen7k 144 7 enterocytes enterocytes NNPS cord-346964-9afuen7k 144 8 , , , cord-346964-9afuen7k 144 9 tTG tTG NNP cord-346964-9afuen7k 144 10 deamidates deamidate VBZ cord-346964-9afuen7k 144 11 gluten gluten NN cord-346964-9afuen7k 144 12 molecules molecule NNS cord-346964-9afuen7k 144 13 that that WDT cord-346964-9afuen7k 144 14 facilitate facilitate VBP cord-346964-9afuen7k 144 15 their -PRON- PRP$ cord-346964-9afuen7k 144 16 binding binding NN cord-346964-9afuen7k 144 17 to to IN cord-346964-9afuen7k 144 18 HLA HLA NNP cord-346964-9afuen7k 144 19 - - HYPH cord-346964-9afuen7k 144 20 DQ2 DQ2 NNP cord-346964-9afuen7k 144 21 and and CC cord-346964-9afuen7k 144 22 DQ8-bearing dq8-beare VBG cord-346964-9afuen7k 144 23 antigen antigen NN cord-346964-9afuen7k 144 24 - - HYPH cord-346964-9afuen7k 144 25 presenting present VBG cord-346964-9afuen7k 144 26 cells cell NNS cord-346964-9afuen7k 144 27 . . . cord-346964-9afuen7k 145 1 When when WRB cord-346964-9afuen7k 145 2 gluten gluten NN cord-346964-9afuen7k 145 3 is be VBZ cord-346964-9afuen7k 145 4 presented present VBN cord-346964-9afuen7k 145 5 to to IN cord-346964-9afuen7k 145 6 lamina lamina JJ cord-346964-9afuen7k 145 7 propria propria NNP cord-346964-9afuen7k 145 8 CD4 CD4 NNP cord-346964-9afuen7k 145 9 þ þ NNP cord-346964-9afuen7k 145 10 helper helper NN cord-346964-9afuen7k 145 11 T t NN cord-346964-9afuen7k 145 12 cells cell NNS cord-346964-9afuen7k 145 13 , , , cord-346964-9afuen7k 145 14 they -PRON- PRP cord-346964-9afuen7k 145 15 become become VBP cord-346964-9afuen7k 145 16 activated activate VBN cord-346964-9afuen7k 145 17 to to IN cord-346964-9afuen7k 145 18 secrete secrete JJ cord-346964-9afuen7k 145 19 INF inf NN cord-346964-9afuen7k 145 20 gamma gamma NN cord-346964-9afuen7k 145 21 and and CC cord-346964-9afuen7k 145 22 induce induce VB cord-346964-9afuen7k 145 23 upregulation upregulation NN cord-346964-9afuen7k 145 24 of of IN cord-346964-9afuen7k 145 25 IL15 IL15 NNP cord-346964-9afuen7k 145 26 that that IN cord-346964-9afuen7k 145 27 in in IN cord-346964-9afuen7k 145 28 turn turn NN cord-346964-9afuen7k 145 29 boosts boost VBZ cord-346964-9afuen7k 145 30 IEL IEL NNP cord-346964-9afuen7k 145 31 - - HYPH cord-346964-9afuen7k 145 32 mediated mediate VBN cord-346964-9afuen7k 145 33 cytotoxicity cytotoxicity NN cord-346964-9afuen7k 145 34 . . . cord-346964-9afuen7k 146 1 IELs iel NNS cord-346964-9afuen7k 146 2 , , , cord-346964-9afuen7k 146 3 under under IN cord-346964-9afuen7k 146 4 the the DT cord-346964-9afuen7k 146 5 influence influence NN cord-346964-9afuen7k 146 6 of of IN cord-346964-9afuen7k 146 7 IL15 IL15 NNP cord-346964-9afuen7k 146 8 , , , cord-346964-9afuen7k 146 9 gain gain VB cord-346964-9afuen7k 146 10 NK nk NN cord-346964-9afuen7k 146 11 - - HYPH cord-346964-9afuen7k 146 12 cell cell NN cord-346964-9afuen7k 146 13 - - HYPH cord-346964-9afuen7k 146 14 like like JJ cord-346964-9afuen7k 146 15 properties property NNS cord-346964-9afuen7k 146 16 and and CC cord-346964-9afuen7k 146 17 cause cause VB cord-346964-9afuen7k 146 18 enterocyte enterocyte NNP cord-346964-9afuen7k 146 19 damage damage NN cord-346964-9afuen7k 147 1 ( ( -LRB- cord-346964-9afuen7k 147 2 Figure figure NN cord-346964-9afuen7k 147 3 5 5 CD cord-346964-9afuen7k 147 4 ) ) -RRB- cord-346964-9afuen7k 147 5 . . . cord-346964-9afuen7k 148 1 Tissue tissue NN cord-346964-9afuen7k 148 2 damage damage NN cord-346964-9afuen7k 148 3 leads lead VBZ cord-346964-9afuen7k 148 4 to to IN cord-346964-9afuen7k 148 5 tTG tTG NNP cord-346964-9afuen7k 148 6 secretion secretion NN cord-346964-9afuen7k 148 7 and and CC cord-346964-9afuen7k 148 8 deamidation deamidation NN cord-346964-9afuen7k 148 9 of of IN cord-346964-9afuen7k 148 10 more more JJR cord-346964-9afuen7k 148 11 gluten gluten NN cord-346964-9afuen7k 148 12 peptides peptide NNS cord-346964-9afuen7k 148 13 . . . cord-346964-9afuen7k 149 1 Because because IN cord-346964-9afuen7k 149 2 of of IN cord-346964-9afuen7k 149 3 the the DT cord-346964-9afuen7k 149 4 immunopathologic immunopathologic JJ cord-346964-9afuen7k 149 5 basis basis NN cord-346964-9afuen7k 149 6 of of IN cord-346964-9afuen7k 149 7 the the DT cord-346964-9afuen7k 149 8 disease disease NN cord-346964-9afuen7k 149 9 , , , cord-346964-9afuen7k 149 10 there there EX cord-346964-9afuen7k 149 11 is be VBZ cord-346964-9afuen7k 149 12 a a DT cord-346964-9afuen7k 149 13 complex complex JJ cord-346964-9afuen7k 149 14 and and CC cord-346964-9afuen7k 149 15 heterogeneous heterogeneous JJ cord-346964-9afuen7k 149 16 population population NN cord-346964-9afuen7k 149 17 of of IN cord-346964-9afuen7k 149 18 inflammatory inflammatory JJ cord-346964-9afuen7k 149 19 cells cell NNS cord-346964-9afuen7k 149 20 in in IN cord-346964-9afuen7k 149 21 the the DT cord-346964-9afuen7k 149 22 lamina lamina JJ cord-346964-9afuen7k 149 23 propria propria NN cord-346964-9afuen7k 149 24 comprising comprise VBG cord-346964-9afuen7k 149 25 plasma plasma NN cord-346964-9afuen7k 149 26 cells cell NNS cord-346964-9afuen7k 149 27 that that WDT cord-346964-9afuen7k 149 28 locally locally RB cord-346964-9afuen7k 149 29 produce produce VBP cord-346964-9afuen7k 149 30 antigliadin antigliadin NNS cord-346964-9afuen7k 149 31 antibodies antibody NNS cord-346964-9afuen7k 149 32 and and CC cord-346964-9afuen7k 149 33 antiendomysial antiendomysial JJ cord-346964-9afuen7k 149 34 antibodies antibody NNS cord-346964-9afuen7k 149 35 , , , cord-346964-9afuen7k 149 36 T t NN cord-346964-9afuen7k 149 37 cells cell NNS cord-346964-9afuen7k 149 38 that that WDT cord-346964-9afuen7k 149 39 include include VBP cord-346964-9afuen7k 149 40 predominantly predominantly RB cord-346964-9afuen7k 149 41 helper helper NN cord-346964-9afuen7k 149 42 T t NN cord-346964-9afuen7k 149 43 cells cell NNS cord-346964-9afuen7k 149 44 as as RB cord-346964-9afuen7k 149 45 well well RB cord-346964-9afuen7k 149 46 as as IN cord-346964-9afuen7k 149 47 few few JJ cord-346964-9afuen7k 149 48 cytotoxic cytotoxic JJ cord-346964-9afuen7k 149 49 cells cell NNS cord-346964-9afuen7k 149 50 . . . cord-346964-9afuen7k 150 1 Also also RB cord-346964-9afuen7k 150 2 , , , cord-346964-9afuen7k 150 3 neutrophils neutrophil NNS cord-346964-9afuen7k 150 4 , , , cord-346964-9afuen7k 150 5 eosinophils eosinophil NNS cord-346964-9afuen7k 150 6 , , , cord-346964-9afuen7k 150 7 and and CC cord-346964-9afuen7k 150 8 mast mast NN cord-346964-9afuen7k 150 9 cells cell NNS cord-346964-9afuen7k 150 10 may may MD cord-346964-9afuen7k 150 11 be be VB cord-346964-9afuen7k 150 12 found find VBN cord-346964-9afuen7k 150 13 in in IN cord-346964-9afuen7k 150 14 varying vary VBG cord-346964-9afuen7k 150 15 numbers number NNS cord-346964-9afuen7k 150 16 , , , cord-346964-9afuen7k 150 17 though though IN cord-346964-9afuen7k 150 18 grading grade VBG cord-346964-9afuen7k 150 19 this this DT cord-346964-9afuen7k 150 20 inflammatory inflammatory JJ cord-346964-9afuen7k 150 21 reaction reaction NN cord-346964-9afuen7k 150 22 is be VBZ cord-346964-9afuen7k 150 23 difficult difficult JJ cord-346964-9afuen7k 150 24 and and CC cord-346964-9afuen7k 150 25 impractical impractical JJ cord-346964-9afuen7k 150 26 . . . cord-346964-9afuen7k 151 1 Since since IN cord-346964-9afuen7k 151 2 none none NN cord-346964-9afuen7k 151 3 of of IN cord-346964-9afuen7k 151 4 these these DT cord-346964-9afuen7k 151 5 changes change NNS cord-346964-9afuen7k 151 6 is be VBZ cord-346964-9afuen7k 151 7 specific specific JJ cord-346964-9afuen7k 151 8 to to IN cord-346964-9afuen7k 151 9 CD CD NNP cord-346964-9afuen7k 151 10 , , , cord-346964-9afuen7k 151 11 intraepithelial intraepithelial NNP cord-346964-9afuen7k 151 12 lymphocytosis lymphocytosis FW cord-346964-9afuen7k 151 13 ( ( -LRB- cord-346964-9afuen7k 151 14 IELosis IELosis NNP cord-346964-9afuen7k 151 15 ) ) -RRB- cord-346964-9afuen7k 151 16 and and CC cord-346964-9afuen7k 151 17 architectural architectural JJ cord-346964-9afuen7k 151 18 changes change NNS cord-346964-9afuen7k 151 19 effecting effect VBG cord-346964-9afuen7k 151 20 villous villous NNP cord-346964-9afuen7k 151 21 to to TO cord-346964-9afuen7k 151 22 crypt crypt VB cord-346964-9afuen7k 151 23 ratio ratio NN cord-346964-9afuen7k 151 24 remain remain VBP cord-346964-9afuen7k 151 25 as as IN cord-346964-9afuen7k 151 26 the the DT cord-346964-9afuen7k 151 27 main main JJ cord-346964-9afuen7k 151 28 diagnostic diagnostic JJ cord-346964-9afuen7k 151 29 parameters parameter NNS cord-346964-9afuen7k 151 30 of of IN cord-346964-9afuen7k 151 31 pathological pathological JJ cord-346964-9afuen7k 151 32 evaluation evaluation NN cord-346964-9afuen7k 151 33 . . . cord-346964-9afuen7k 152 1 Gluten gluten JJ cord-346964-9afuen7k 152 2 sensitivity sensitivity NN cord-346964-9afuen7k 152 3 has have VBZ cord-346964-9afuen7k 152 4 also also RB cord-346964-9afuen7k 152 5 been be VBN cord-346964-9afuen7k 152 6 known know VBN cord-346964-9afuen7k 152 7 to to TO cord-346964-9afuen7k 152 8 affect affect VB cord-346964-9afuen7k 152 9 other other JJ cord-346964-9afuen7k 152 10 parts part NNS cord-346964-9afuen7k 152 11 of of IN cord-346964-9afuen7k 152 12 the the DT cord-346964-9afuen7k 152 13 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 152 14 tract tract NN cord-346964-9afuen7k 152 15 , , , cord-346964-9afuen7k 152 16 ( ( -LRB- cord-346964-9afuen7k 152 17 1 1 LS cord-346964-9afuen7k 152 18 ) ) -RRB- cord-346964-9afuen7k 152 19 Normal normal JJ cord-346964-9afuen7k 152 20 absorption absorption NN cord-346964-9afuen7k 152 21 of of IN cord-346964-9afuen7k 152 22 carbohydrates carbohydrate NNS cord-346964-9afuen7k 152 23 with with IN cord-346964-9afuen7k 152 24 intact intact JJ cord-346964-9afuen7k 152 25 brush brush NN cord-346964-9afuen7k 152 26 border border NN cord-346964-9afuen7k 152 27 hydrolase hydrolase NN cord-346964-9afuen7k 152 28 activity activity NN cord-346964-9afuen7k 152 29 . . . cord-346964-9afuen7k 153 1 Lactase lactase NN cord-346964-9afuen7k 153 2 acts act VBZ cord-346964-9afuen7k 153 3 upon upon IN cord-346964-9afuen7k 153 4 luminal luminal JJ cord-346964-9afuen7k 153 5 lactose lactose NN cord-346964-9afuen7k 153 6 and and CC cord-346964-9afuen7k 153 7 cleaves cleave VBZ cord-346964-9afuen7k 153 8 it -PRON- PRP cord-346964-9afuen7k 153 9 to to IN cord-346964-9afuen7k 153 10 glucose glucose NN cord-346964-9afuen7k 153 11 and and CC cord-346964-9afuen7k 153 12 galactose galactose NN cord-346964-9afuen7k 153 13 that that WDT cord-346964-9afuen7k 153 14 can can MD cord-346964-9afuen7k 153 15 then then RB cord-346964-9afuen7k 153 16 be be VB cord-346964-9afuen7k 153 17 absorbed absorb VBN cord-346964-9afuen7k 153 18 by by IN cord-346964-9afuen7k 153 19 the the DT cord-346964-9afuen7k 153 20 intestines intestine NNS cord-346964-9afuen7k 153 21 . . . cord-346964-9afuen7k 154 1 ( ( -LRB- cord-346964-9afuen7k 154 2 2 2 LS cord-346964-9afuen7k 154 3 ) ) -RRB- cord-346964-9afuen7k 155 1 In in IN cord-346964-9afuen7k 155 2 lactase lactase NN cord-346964-9afuen7k 155 3 deficiency deficiency NN cord-346964-9afuen7k 155 4 , , , cord-346964-9afuen7k 155 5 this this DT cord-346964-9afuen7k 155 6 cleavage cleavage NN cord-346964-9afuen7k 155 7 can can MD cord-346964-9afuen7k 155 8 not not RB cord-346964-9afuen7k 155 9 take take VB cord-346964-9afuen7k 155 10 place place NN cord-346964-9afuen7k 155 11 leaving leave VBG cord-346964-9afuen7k 155 12 lactose lactose NN cord-346964-9afuen7k 155 13 intact intact JJ cord-346964-9afuen7k 155 14 until until IN cord-346964-9afuen7k 155 15 it -PRON- PRP cord-346964-9afuen7k 155 16 reaches reach VBZ cord-346964-9afuen7k 155 17 the the DT cord-346964-9afuen7k 155 18 colon colon NN cord-346964-9afuen7k 155 19 where where WRB cord-346964-9afuen7k 155 20 fermentation fermentation NN cord-346964-9afuen7k 155 21 by by IN cord-346964-9afuen7k 155 22 intestinal intestinal JJ cord-346964-9afuen7k 155 23 microflora microflora NN cord-346964-9afuen7k 155 24 occurs occur VBZ cord-346964-9afuen7k 155 25 resulting result VBG cord-346964-9afuen7k 155 26 in in IN cord-346964-9afuen7k 155 27 gas gas NN cord-346964-9afuen7k 155 28 formation formation NN cord-346964-9afuen7k 155 29 . . . cord-346964-9afuen7k 156 1 The the DT cord-346964-9afuen7k 156 2 intact intact JJ cord-346964-9afuen7k 156 3 lactose lactose NN cord-346964-9afuen7k 156 4 causes cause VBZ cord-346964-9afuen7k 156 5 osmotic osmotic JJ cord-346964-9afuen7k 156 6 diarrhea diarrhea NN cord-346964-9afuen7k 156 7 due due IN cord-346964-9afuen7k 156 8 to to IN cord-346964-9afuen7k 156 9 its -PRON- PRP$ cord-346964-9afuen7k 156 10 voluminous voluminous JJ cord-346964-9afuen7k 156 11 effect effect NN cord-346964-9afuen7k 156 12 in in IN cord-346964-9afuen7k 156 13 the the DT cord-346964-9afuen7k 156 14 lumen lumen NN cord-346964-9afuen7k 156 15 . . . cord-346964-9afuen7k 157 1 In in IN cord-346964-9afuen7k 157 2 case case NN cord-346964-9afuen7k 157 3 of of IN cord-346964-9afuen7k 157 4 hypolactasemia hypolactasemia NN cord-346964-9afuen7k 157 5 , , , cord-346964-9afuen7k 157 6 little little JJ cord-346964-9afuen7k 157 7 cleavage cleavage NN cord-346964-9afuen7k 157 8 of of IN cord-346964-9afuen7k 157 9 glucose glucose NN cord-346964-9afuen7k 157 10 and and CC cord-346964-9afuen7k 157 11 galactose galactose NN cord-346964-9afuen7k 157 12 occurs occur VBZ cord-346964-9afuen7k 157 13 . . . cord-346964-9afuen7k 158 1 SCFA SCFA NNP cord-346964-9afuen7k 158 2 , , , cord-346964-9afuen7k 158 3 Short short JJ cord-346964-9afuen7k 158 4 chain chain NN cord-346964-9afuen7k 158 5 fatty fatty JJ cord-346964-9afuen7k 158 6 acids acid NNS cord-346964-9afuen7k 158 7 . . . cord-346964-9afuen7k 159 1 Pathogenesis Pathogenesis NNP cord-346964-9afuen7k 159 2 of of IN cord-346964-9afuen7k 159 3 celiac celiac JJ cord-346964-9afuen7k 159 4 disease disease NN cord-346964-9afuen7k 159 5 ( ( -LRB- cord-346964-9afuen7k 159 6 CD CD NNP cord-346964-9afuen7k 159 7 ) ) -RRB- cord-346964-9afuen7k 159 8 . . . cord-346964-9afuen7k 160 1 Following follow VBG cord-346964-9afuen7k 160 2 uptake uptake NN cord-346964-9afuen7k 160 3 of of IN cord-346964-9afuen7k 160 4 gluten gluten NN cord-346964-9afuen7k 160 5 by by IN cord-346964-9afuen7k 160 6 the the DT cord-346964-9afuen7k 160 7 enterocytes enterocyte NNS cord-346964-9afuen7k 160 8 , , , cord-346964-9afuen7k 160 9 tissue tissue NN cord-346964-9afuen7k 160 10 transglutaminase transglutaminase NN cord-346964-9afuen7k 160 11 deamidates deamidate VBZ cord-346964-9afuen7k 160 12 gluten gluten NN cord-346964-9afuen7k 160 13 molecules molecule NNS cord-346964-9afuen7k 160 14 , , , cord-346964-9afuen7k 160 15 which which WDT cord-346964-9afuen7k 160 16 facilitates facilitate VBZ cord-346964-9afuen7k 160 17 their -PRON- PRP$ cord-346964-9afuen7k 160 18 binding binding NN cord-346964-9afuen7k 160 19 to to IN cord-346964-9afuen7k 160 20 HLA HLA NNP cord-346964-9afuen7k 160 21 - - HYPH cord-346964-9afuen7k 160 22 DQ2 DQ2 NNP cord-346964-9afuen7k 160 23 and and CC cord-346964-9afuen7k 160 24 DQ8-bearing dq8-beare VBG cord-346964-9afuen7k 160 25 antigen antigen NN cord-346964-9afuen7k 160 26 presenting present VBG cord-346964-9afuen7k 160 27 cells cell NNS cord-346964-9afuen7k 160 28 . . . cord-346964-9afuen7k 161 1 When when WRB cord-346964-9afuen7k 161 2 gluten gluten NN cord-346964-9afuen7k 161 3 is be VBZ cord-346964-9afuen7k 161 4 presented present VBN cord-346964-9afuen7k 161 5 to to IN cord-346964-9afuen7k 161 6 lamina lamina NN cord-346964-9afuen7k 161 7 propria propria NNP cord-346964-9afuen7k 161 8 CD4þ CD4þ NNP cord-346964-9afuen7k 161 9 helper helper NN cord-346964-9afuen7k 161 10 T t NN cord-346964-9afuen7k 161 11 cells cell NNS cord-346964-9afuen7k 161 12 , , , cord-346964-9afuen7k 161 13 they -PRON- PRP cord-346964-9afuen7k 161 14 become become VBP cord-346964-9afuen7k 161 15 activated activate VBN cord-346964-9afuen7k 161 16 to to TO cord-346964-9afuen7k 161 17 secrete secrete VB cord-346964-9afuen7k 161 18 certain certain JJ cord-346964-9afuen7k 161 19 cytokines cytokine NNS cord-346964-9afuen7k 161 20 including include VBG cord-346964-9afuen7k 161 21 INF inf NN cord-346964-9afuen7k 161 22 gamma gamma NN cord-346964-9afuen7k 161 23 and and CC cord-346964-9afuen7k 161 24 IL15 IL15 NNP cord-346964-9afuen7k 161 25 . . . cord-346964-9afuen7k 162 1 The the DT cord-346964-9afuen7k 162 2 latter latter JJ cord-346964-9afuen7k 162 3 induces induce VBZ cord-346964-9afuen7k 162 4 CD8þ CD8þ NNP cord-346964-9afuen7k 162 5 T T NNP cord-346964-9afuen7k 162 6 - - HYPH cord-346964-9afuen7k 162 7 cell cell NN cord-346964-9afuen7k 162 8 influx influx NN cord-346964-9afuen7k 162 9 to to IN cord-346964-9afuen7k 162 10 the the DT cord-346964-9afuen7k 162 11 surface surface NN cord-346964-9afuen7k 162 12 epithelium epithelium NN cord-346964-9afuen7k 162 13 , , , cord-346964-9afuen7k 162 14 thus thus RB cord-346964-9afuen7k 162 15 causing cause VBG cord-346964-9afuen7k 162 16 intraepithelial intraepithelial JJ cord-346964-9afuen7k 162 17 lymphocytosis lymphocytosis FW cord-346964-9afuen7k 162 18 ( ( -LRB- cord-346964-9afuen7k 162 19 IELosis IELosis NNP cord-346964-9afuen7k 162 20 ) ) -RRB- cord-346964-9afuen7k 162 21 . . . cord-346964-9afuen7k 163 1 Intraepithelial intraepithelial JJ cord-346964-9afuen7k 163 2 lymphocytes lymphocyte NNS cord-346964-9afuen7k 163 3 ( ( -LRB- cord-346964-9afuen7k 163 4 IELs iel NNS cord-346964-9afuen7k 163 5 ) ) -RRB- cord-346964-9afuen7k 163 6 under under IN cord-346964-9afuen7k 163 7 the the DT cord-346964-9afuen7k 163 8 influence influence NN cord-346964-9afuen7k 163 9 of of IN cord-346964-9afuen7k 163 10 IL15 IL15 NNP cord-346964-9afuen7k 163 11 gain gain VB cord-346964-9afuen7k 163 12 NK nk NN cord-346964-9afuen7k 163 13 - - HYPH cord-346964-9afuen7k 163 14 cell cell NN cord-346964-9afuen7k 163 15 - - HYPH cord-346964-9afuen7k 163 16 like like JJ cord-346964-9afuen7k 163 17 properties property NNS cord-346964-9afuen7k 163 18 and and CC cord-346964-9afuen7k 163 19 cause cause VB cord-346964-9afuen7k 163 20 enterocyte enterocyte NNP cord-346964-9afuen7k 163 21 damage damage NN cord-346964-9afuen7k 163 22 . . . cord-346964-9afuen7k 164 1 including include VBG cord-346964-9afuen7k 164 2 esophagus esophagus NN cord-346964-9afuen7k 164 3 , , , cord-346964-9afuen7k 164 4 stomach stomach NN cord-346964-9afuen7k 164 5 , , , cord-346964-9afuen7k 164 6 and and CC cord-346964-9afuen7k 164 7 large large JJ cord-346964-9afuen7k 164 8 intestine intestine NN cord-346964-9afuen7k 164 9 , , , cord-346964-9afuen7k 164 10 and and CC cord-346964-9afuen7k 164 11 interestingly interestingly RB cord-346964-9afuen7k 164 12 enough enough RB cord-346964-9afuen7k 164 13 , , , cord-346964-9afuen7k 164 14 IELs iel NNS cord-346964-9afuen7k 164 15 are be VBP cord-346964-9afuen7k 164 16 also also RB cord-346964-9afuen7k 164 17 increased increase VBN cord-346964-9afuen7k 164 18 in in IN cord-346964-9afuen7k 164 19 these these DT cord-346964-9afuen7k 164 20 areas area NNS cord-346964-9afuen7k 164 21 in in IN cord-346964-9afuen7k 164 22 the the DT cord-346964-9afuen7k 164 23 form form NN cord-346964-9afuen7k 164 24 of of IN cord-346964-9afuen7k 164 25 lymphocytic lymphocytic JJ cord-346964-9afuen7k 164 26 esophagitis esophagitis NN cord-346964-9afuen7k 164 27 , , , cord-346964-9afuen7k 164 28 gastritis gastritis NN cord-346964-9afuen7k 164 29 , , , cord-346964-9afuen7k 164 30 and and CC cord-346964-9afuen7k 164 31 colitis colitis NN cord-346964-9afuen7k 164 32 . . . cord-346964-9afuen7k 165 1 Clinical clinical JJ cord-346964-9afuen7k 165 2 presentation presentation NN cord-346964-9afuen7k 165 3 varies vary VBZ cord-346964-9afuen7k 165 4 from from IN cord-346964-9afuen7k 165 5 full full RB cord-346964-9afuen7k 165 6 - - HYPH cord-346964-9afuen7k 165 7 blown blown JJ cord-346964-9afuen7k 165 8 malabsorption malabsorption NN cord-346964-9afuen7k 165 9 with with IN cord-346964-9afuen7k 165 10 weight weight NN cord-346964-9afuen7k 165 11 loss loss NN cord-346964-9afuen7k 165 12 , , , cord-346964-9afuen7k 165 13 diarrhea diarrhea NN cord-346964-9afuen7k 165 14 , , , cord-346964-9afuen7k 165 15 and and CC cord-346964-9afuen7k 165 16 steatorrhea steatorrhea JJ cord-346964-9afuen7k 165 17 to to IN cord-346964-9afuen7k 165 18 more more RBR cord-346964-9afuen7k 165 19 subtle subtle JJ cord-346964-9afuen7k 165 20 symptoms symptom NNS cord-346964-9afuen7k 165 21 such such JJ cord-346964-9afuen7k 165 22 as as IN cord-346964-9afuen7k 165 23 folate folate NN cord-346964-9afuen7k 165 24 or or CC cord-346964-9afuen7k 165 25 iron iron NN cord-346964-9afuen7k 165 26 deficiency deficiency NN cord-346964-9afuen7k 165 27 anemia anemia NN cord-346964-9afuen7k 165 28 , , , cord-346964-9afuen7k 165 29 flatulence flatulence NN cord-346964-9afuen7k 165 30 , , , cord-346964-9afuen7k 165 31 episodic episodic JJ cord-346964-9afuen7k 165 32 diarrhea diarrhea NN cord-346964-9afuen7k 165 33 , , , cord-346964-9afuen7k 165 34 loose loose JJ cord-346964-9afuen7k 165 35 stools stool NNS cord-346964-9afuen7k 165 36 , , , cord-346964-9afuen7k 165 37 neurological neurological JJ cord-346964-9afuen7k 165 38 problems problem NNS cord-346964-9afuen7k 165 39 , , , cord-346964-9afuen7k 165 40 osteoporosis osteoporosis NN cord-346964-9afuen7k 165 41 , , , cord-346964-9afuen7k 165 42 and and CC cord-346964-9afuen7k 165 43 vitamins vitamin NNS cord-346964-9afuen7k 165 44 K k NN cord-346964-9afuen7k 165 45 and and CC cord-346964-9afuen7k 165 46 D d NN cord-346964-9afuen7k 165 47 deficiencies deficiency NNS cord-346964-9afuen7k 165 48 in in IN cord-346964-9afuen7k 165 49 as as RB cord-346964-9afuen7k 165 50 many many JJ cord-346964-9afuen7k 165 51 as as IN cord-346964-9afuen7k 165 52 50 50 CD cord-346964-9afuen7k 165 53 % % NN cord-346964-9afuen7k 165 54 of of IN cord-346964-9afuen7k 165 55 patients patient NNS cord-346964-9afuen7k 165 56 . . . cord-346964-9afuen7k 166 1 In in IN cord-346964-9afuen7k 166 2 children child NNS cord-346964-9afuen7k 166 3 , , , cord-346964-9afuen7k 166 4 usually usually RB cord-346964-9afuen7k 166 5 within within IN cord-346964-9afuen7k 166 6 a a DT cord-346964-9afuen7k 166 7 few few JJ cord-346964-9afuen7k 166 8 months month NNS cord-346964-9afuen7k 166 9 of of IN cord-346964-9afuen7k 166 10 introducing introduce VBG cord-346964-9afuen7k 166 11 the the DT cord-346964-9afuen7k 166 12 child child NN cord-346964-9afuen7k 166 13 to to IN cord-346964-9afuen7k 166 14 wheat wheat NN cord-346964-9afuen7k 166 15 - - HYPH cord-346964-9afuen7k 166 16 based base VBN cord-346964-9afuen7k 166 17 foods food NNS cord-346964-9afuen7k 166 18 , , , cord-346964-9afuen7k 166 19 the the DT cord-346964-9afuen7k 166 20 classical classical JJ cord-346964-9afuen7k 166 21 syndrome syndrome NN cord-346964-9afuen7k 166 22 of of IN cord-346964-9afuen7k 166 23 chronic chronic JJ cord-346964-9afuen7k 166 24 diarrhea diarrhea NN cord-346964-9afuen7k 166 25 , , , cord-346964-9afuen7k 166 26 steatorrhea steatorrhea NN cord-346964-9afuen7k 166 27 , , , cord-346964-9afuen7k 166 28 abdominal abdominal JJ cord-346964-9afuen7k 166 29 distension distension NN cord-346964-9afuen7k 166 30 , , , cord-346964-9afuen7k 166 31 and and CC cord-346964-9afuen7k 166 32 failure failure NN cord-346964-9afuen7k 166 33 to to TO cord-346964-9afuen7k 166 34 thrive thrive VB cord-346964-9afuen7k 166 35 appears appear VBZ cord-346964-9afuen7k 166 36 between between IN cord-346964-9afuen7k 166 37 6 6 CD cord-346964-9afuen7k 166 38 months month NNS cord-346964-9afuen7k 166 39 and and CC cord-346964-9afuen7k 166 40 2 2 CD cord-346964-9afuen7k 166 41 years year NNS cord-346964-9afuen7k 166 42 of of IN cord-346964-9afuen7k 166 43 age age NN cord-346964-9afuen7k 166 44 . . . cord-346964-9afuen7k 167 1 Both both DT cord-346964-9afuen7k 167 2 weight weight NN cord-346964-9afuen7k 167 3 ( ( -LRB- cord-346964-9afuen7k 167 4 40 40 CD cord-346964-9afuen7k 167 5 % % NN cord-346964-9afuen7k 167 6 below below IN cord-346964-9afuen7k 167 7 10th 10th JJ cord-346964-9afuen7k 167 8 centile centile NN cord-346964-9afuen7k 167 9 ) ) -RRB- cord-346964-9afuen7k 167 10 , , , cord-346964-9afuen7k 167 11 though though IN cord-346964-9afuen7k 167 12 more more RBR cord-346964-9afuen7k 167 13 often often RB cord-346964-9afuen7k 167 14 , , , cord-346964-9afuen7k 167 15 and and CC cord-346964-9afuen7k 167 16 growth growth NN cord-346964-9afuen7k 167 17 ( ( -LRB- cord-346964-9afuen7k 167 18 25 25 CD cord-346964-9afuen7k 167 19 % % NN cord-346964-9afuen7k 167 20 below below IN cord-346964-9afuen7k 167 21 10th 10th JJ cord-346964-9afuen7k 167 22 centile centile NN cord-346964-9afuen7k 167 23 ) ) -RRB- cord-346964-9afuen7k 167 24 are be VBP cord-346964-9afuen7k 167 25 affected affect VBN cord-346964-9afuen7k 167 26 in in IN cord-346964-9afuen7k 167 27 these these DT cord-346964-9afuen7k 167 28 children child NNS cord-346964-9afuen7k 167 29 . . . cord-346964-9afuen7k 168 1 Current current JJ cord-346964-9afuen7k 168 2 estimates estimate NNS cord-346964-9afuen7k 168 3 show show VBP cord-346964-9afuen7k 168 4 that that IN cord-346964-9afuen7k 168 5 the the DT cord-346964-9afuen7k 168 6 incidence incidence NN cord-346964-9afuen7k 168 7 is be VBZ cord-346964-9afuen7k 168 8 at at IN cord-346964-9afuen7k 168 9 1:100 1:100 CD cord-346964-9afuen7k 168 10 in in IN cord-346964-9afuen7k 168 11 wheat wheat NN cord-346964-9afuen7k 168 12 - - HYPH cord-346964-9afuen7k 168 13 eating eat VBG cord-346964-9afuen7k 168 14 populations population NNS cord-346964-9afuen7k 168 15 such such JJ cord-346964-9afuen7k 168 16 as as IN cord-346964-9afuen7k 168 17 Western Western NNP cord-346964-9afuen7k 168 18 Europe Europe NNP cord-346964-9afuen7k 168 19 and and CC cord-346964-9afuen7k 168 20 North North NNP cord-346964-9afuen7k 168 21 America America NNP cord-346964-9afuen7k 168 22 , , , cord-346964-9afuen7k 168 23 while while IN cord-346964-9afuen7k 168 24 the the DT cord-346964-9afuen7k 168 25 incidence incidence NN cord-346964-9afuen7k 168 26 continues continue VBZ cord-346964-9afuen7k 168 27 to to TO cord-346964-9afuen7k 168 28 rise rise VB cord-346964-9afuen7k 168 29 in in IN cord-346964-9afuen7k 168 30 Eastern eastern JJ cord-346964-9afuen7k 168 31 societies society NNS cord-346964-9afuen7k 168 32 , , , cord-346964-9afuen7k 168 33 possibly possibly RB cord-346964-9afuen7k 168 34 , , , cord-346964-9afuen7k 168 35 as as IN cord-346964-9afuen7k 168 36 a a DT cord-346964-9afuen7k 168 37 result result NN cord-346964-9afuen7k 168 38 of of IN cord-346964-9afuen7k 168 39 ' ' `` cord-346964-9afuen7k 168 40 Western western JJ cord-346964-9afuen7k 168 41 style style NN cord-346964-9afuen7k 168 42 ' ' '' cord-346964-9afuen7k 168 43 eating eat VBG cord-346964-9afuen7k 168 44 habits habit NNS cord-346964-9afuen7k 168 45 . . . cord-346964-9afuen7k 169 1 The the DT cord-346964-9afuen7k 169 2 diagnosis diagnosis NN cord-346964-9afuen7k 169 3 of of IN cord-346964-9afuen7k 169 4 CD CD NNP cord-346964-9afuen7k 169 5 currently currently RB cord-346964-9afuen7k 169 6 relies rely VBZ cord-346964-9afuen7k 169 7 on on IN cord-346964-9afuen7k 169 8 clinicopathologic clinicopathologic NNP cord-346964-9afuen7k 169 9 studies study NNS cord-346964-9afuen7k 169 10 including include VBG cord-346964-9afuen7k 169 11 HLA HLA NNP cord-346964-9afuen7k 169 12 subtyping subtyping NN cord-346964-9afuen7k 169 13 , , , cord-346964-9afuen7k 169 14 serological serological JJ cord-346964-9afuen7k 169 15 tests test NNS cord-346964-9afuen7k 169 16 , , , cord-346964-9afuen7k 169 17 mucosal mucosal JJ cord-346964-9afuen7k 169 18 biopsy biopsy NN cord-346964-9afuen7k 169 19 , , , cord-346964-9afuen7k 169 20 and and CC cord-346964-9afuen7k 169 21 the the DT cord-346964-9afuen7k 169 22 effects effect NNS cord-346964-9afuen7k 169 23 of of IN cord-346964-9afuen7k 169 24 a a DT cord-346964-9afuen7k 169 25 diet diet NN cord-346964-9afuen7k 169 26 free free JJ cord-346964-9afuen7k 169 27 of of IN cord-346964-9afuen7k 169 28 gluten gluten NN cord-346964-9afuen7k 169 29 on on IN cord-346964-9afuen7k 169 30 the the DT cord-346964-9afuen7k 169 31 symptoms symptom NNS cord-346964-9afuen7k 169 32 . . . cord-346964-9afuen7k 170 1 Based base VBN cord-346964-9afuen7k 170 2 on on IN cord-346964-9afuen7k 170 3 a a DT cord-346964-9afuen7k 170 4 substantial substantial JJ cord-346964-9afuen7k 170 5 amount amount NN cord-346964-9afuen7k 170 6 of of IN cord-346964-9afuen7k 170 7 clinical clinical JJ cord-346964-9afuen7k 170 8 research research NN cord-346964-9afuen7k 170 9 including include VBG cord-346964-9afuen7k 170 10 a a DT cord-346964-9afuen7k 170 11 sequence sequence NN cord-346964-9afuen7k 170 12 of of IN cord-346964-9afuen7k 170 13 dynamic dynamic JJ cord-346964-9afuen7k 170 14 studies study NNS cord-346964-9afuen7k 170 15 , , , cord-346964-9afuen7k 170 16 the the DT cord-346964-9afuen7k 170 17 morphological morphological JJ cord-346964-9afuen7k 170 18 continuum continuum NN cord-346964-9afuen7k 170 19 of of IN cord-346964-9afuen7k 170 20 gluten gluten NN cord-346964-9afuen7k 170 21 sensitivity sensitivity NN cord-346964-9afuen7k 170 22 was be VBD cord-346964-9afuen7k 170 23 first first RB cord-346964-9afuen7k 170 24 introduced introduce VBN cord-346964-9afuen7k 170 25 by by IN cord-346964-9afuen7k 170 26 Marsh Marsh NNP cord-346964-9afuen7k 170 27 . . . cord-346964-9afuen7k 171 1 Marsh Marsh NNP cord-346964-9afuen7k 171 2 classification classification NN cord-346964-9afuen7k 171 3 is be VBZ cord-346964-9afuen7k 171 4 comprised comprise VBN cord-346964-9afuen7k 171 5 of of IN cord-346964-9afuen7k 171 6 three three CD cord-346964-9afuen7k 171 7 consecutive consecutive JJ cord-346964-9afuen7k 171 8 states state NNS cord-346964-9afuen7k 171 9 of of IN cord-346964-9afuen7k 171 10 mucosal mucosal JJ cord-346964-9afuen7k 171 11 damage damage NN cord-346964-9afuen7k 171 12 ( ( -LRB- cord-346964-9afuen7k 171 13 types type NNS cord-346964-9afuen7k 171 14 1 1 CD cord-346964-9afuen7k 171 15 - - SYM cord-346964-9afuen7k 171 16 3 3 CD cord-346964-9afuen7k 171 17 ) ) -RRB- cord-346964-9afuen7k 171 18 , , , cord-346964-9afuen7k 171 19 including include VBG cord-346964-9afuen7k 171 20 infiltrative infiltrative JJ cord-346964-9afuen7k 171 21 lesion lesion NN cord-346964-9afuen7k 171 22 ( ( -LRB- cord-346964-9afuen7k 171 23 Marsh Marsh NNP cord-346964-9afuen7k 171 24 type type NN cord-346964-9afuen7k 171 25 1 1 CD cord-346964-9afuen7k 171 26 ) ) -RRB- cord-346964-9afuen7k 171 27 characterized characterize VBN cord-346964-9afuen7k 171 28 by by IN cord-346964-9afuen7k 171 29 increased increase VBN cord-346964-9afuen7k 171 30 IELs iel NNS cord-346964-9afuen7k 171 31 in in IN cord-346964-9afuen7k 171 32 the the DT cord-346964-9afuen7k 171 33 villus villus NN cord-346964-9afuen7k 171 34 epithelium epithelium NN cord-346964-9afuen7k 171 35 in in IN cord-346964-9afuen7k 171 36 an an DT cord-346964-9afuen7k 171 37 otherwise otherwise RB cord-346964-9afuen7k 171 38 normal normal JJ cord-346964-9afuen7k 171 39 mucosa mucosa RB cord-346964-9afuen7k 171 40 with with IN cord-346964-9afuen7k 171 41 normal normal JJ cord-346964-9afuen7k 171 42 villous villous JJ cord-346964-9afuen7k 171 43 - - HYPH cord-346964-9afuen7k 171 44 crypt crypt NN cord-346964-9afuen7k 171 45 ratio ratio NN cord-346964-9afuen7k 171 46 , , , cord-346964-9afuen7k 171 47 hyperplastic hyperplastic JJ cord-346964-9afuen7k 171 48 lesion lesion NN cord-346964-9afuen7k 171 49 ( ( -LRB- cord-346964-9afuen7k 171 50 Marsh Marsh NNP cord-346964-9afuen7k 171 51 type type NN cord-346964-9afuen7k 171 52 2 2 CD cord-346964-9afuen7k 171 53 ) ) -RRB- cord-346964-9afuen7k 171 54 characterized characterize VBN cord-346964-9afuen7k 171 55 by by IN cord-346964-9afuen7k 171 56 crypt crypt JJ cord-346964-9afuen7k 171 57 hyperplasia hyperplasia NN cord-346964-9afuen7k 171 58 with with IN cord-346964-9afuen7k 171 59 normal normal JJ cord-346964-9afuen7k 171 60 villi villi NN cord-346964-9afuen7k 171 61 showing show VBG cord-346964-9afuen7k 171 62 increased increase VBN cord-346964-9afuen7k 171 63 IELs iel NNS cord-346964-9afuen7k 171 64 , , , cord-346964-9afuen7k 171 65 and and CC cord-346964-9afuen7k 171 66 destructive destructive JJ cord-346964-9afuen7k 171 67 lesion lesion NN cord-346964-9afuen7k 171 68 ( ( -LRB- cord-346964-9afuen7k 171 69 Marsh Marsh NNP cord-346964-9afuen7k 171 70 type type NN cord-346964-9afuen7k 171 71 3 3 CD cord-346964-9afuen7k 171 72 ) ) -RRB- cord-346964-9afuen7k 171 73 characterized characterize VBN cord-346964-9afuen7k 171 74 by by IN cord-346964-9afuen7k 171 75 flat flat JJ cord-346964-9afuen7k 171 76 mucosa mucosa RB cord-346964-9afuen7k 171 77 with with IN cord-346964-9afuen7k 171 78 crypt crypt JJ cord-346964-9afuen7k 171 79 hyperplasia hyperplasia NN cord-346964-9afuen7k 171 80 and and CC cord-346964-9afuen7k 171 81 increased increase VBD cord-346964-9afuen7k 171 82 IEL IEL NNP cord-346964-9afuen7k 171 83 ( ( -LRB- cord-346964-9afuen7k 171 84 Figure figure NN cord-346964-9afuen7k 171 85 6 6 CD cord-346964-9afuen7k 171 86 ) ) -RRB- cord-346964-9afuen7k 171 87 . . . cord-346964-9afuen7k 172 1 In in IN cord-346964-9afuen7k 172 2 its -PRON- PRP$ cord-346964-9afuen7k 172 3 classical classical JJ cord-346964-9afuen7k 172 4 form form NN cord-346964-9afuen7k 172 5 , , , cord-346964-9afuen7k 172 6 CD cd NN cord-346964-9afuen7k 172 7 results result NNS cord-346964-9afuen7k 172 8 in in IN cord-346964-9afuen7k 172 9 shortened shorten VBN cord-346964-9afuen7k 172 10 , , , cord-346964-9afuen7k 172 11 widened widen VBN cord-346964-9afuen7k 172 12 villi villi NN cord-346964-9afuen7k 172 13 or or CC cord-346964-9afuen7k 172 14 even even RB cord-346964-9afuen7k 172 15 totally totally RB cord-346964-9afuen7k 172 16 flat flat JJ cord-346964-9afuen7k 172 17 mucosa mucosa RB cord-346964-9afuen7k 172 18 with with IN cord-346964-9afuen7k 172 19 hyperplastic hyperplastic JJ cord-346964-9afuen7k 172 20 crypts crypt NNS cord-346964-9afuen7k 172 21 ( ( -LRB- cord-346964-9afuen7k 172 22 Figure Figure NNP cord-346964-9afuen7k 172 23 7(a 7(a CD cord-346964-9afuen7k 172 24 ) ) -RRB- cord-346964-9afuen7k 172 25 and and CC cord-346964-9afuen7k 172 26 7(b 7(b LS cord-346964-9afuen7k 172 27 ) ) -RRB- cord-346964-9afuen7k 172 28 ) ) -RRB- cord-346964-9afuen7k 172 29 . . . cord-346964-9afuen7k 173 1 These these DT cord-346964-9afuen7k 173 2 architectural architectural JJ cord-346964-9afuen7k 173 3 changes change NNS cord-346964-9afuen7k 173 4 are be VBP cord-346964-9afuen7k 173 5 preceded precede VBN cord-346964-9afuen7k 173 6 by by IN cord-346964-9afuen7k 173 7 an an DT cord-346964-9afuen7k 173 8 increase increase NN cord-346964-9afuen7k 173 9 in in IN cord-346964-9afuen7k 173 10 the the DT cord-346964-9afuen7k 173 11 number number NN cord-346964-9afuen7k 173 12 of of IN cord-346964-9afuen7k 173 13 IELs iel NNS cord-346964-9afuen7k 173 14 over over IN cord-346964-9afuen7k 173 15 the the DT cord-346964-9afuen7k 173 16 normal normal JJ cord-346964-9afuen7k 173 17 numbers number NNS cord-346964-9afuen7k 173 18 ( ( -LRB- cord-346964-9afuen7k 173 19 Figure figure NN cord-346964-9afuen7k 173 20 8 8 CD cord-346964-9afuen7k 173 21 ( ( -LRB- cord-346964-9afuen7k 173 22 a a DT cord-346964-9afuen7k 173 23 ) ) -RRB- cord-346964-9afuen7k 173 24 and and CC cord-346964-9afuen7k 173 25 8(b 8(b LS cord-346964-9afuen7k 173 26 ) ) -RRB- cord-346964-9afuen7k 173 27 ) ) -RRB- cord-346964-9afuen7k 173 28 , , , cord-346964-9afuen7k 173 29 corresponding correspond VBG cord-346964-9afuen7k 173 30 to to IN cord-346964-9afuen7k 173 31 the the DT cord-346964-9afuen7k 173 32 cell cell NN cord-346964-9afuen7k 173 33 - - HYPH cord-346964-9afuen7k 173 34 mediated mediate VBN cord-346964-9afuen7k 173 35 immune immune JJ cord-346964-9afuen7k 173 36 nature nature NN cord-346964-9afuen7k 173 37 of of IN cord-346964-9afuen7k 173 38 the the DT cord-346964-9afuen7k 173 39 disorder disorder NN cord-346964-9afuen7k 173 40 , , , cord-346964-9afuen7k 173 41 and and CC cord-346964-9afuen7k 173 42 it -PRON- PRP cord-346964-9afuen7k 173 43 is be VBZ cord-346964-9afuen7k 173 44 this this DT cord-346964-9afuen7k 173 45 group group NN cord-346964-9afuen7k 173 46 of of IN cord-346964-9afuen7k 173 47 cases case NNS cord-346964-9afuen7k 173 48 that that WDT cord-346964-9afuen7k 173 49 cause cause VBP cord-346964-9afuen7k 173 50 difficulty difficulty NN cord-346964-9afuen7k 173 51 in in IN cord-346964-9afuen7k 173 52 the the DT cord-346964-9afuen7k 173 53 differential differential JJ cord-346964-9afuen7k 173 54 diagnosis diagnosis NN cord-346964-9afuen7k 173 55 . . . cord-346964-9afuen7k 174 1 IELs iel NNS cord-346964-9afuen7k 174 2 have have VBP cord-346964-9afuen7k 174 3 been be VBN cord-346964-9afuen7k 174 4 considered consider VBN cord-346964-9afuen7k 174 5 to to TO cord-346964-9afuen7k 174 6 be be VB cord-346964-9afuen7k 174 7 responsible responsible JJ cord-346964-9afuen7k 174 8 for for IN cord-346964-9afuen7k 174 9 the the DT cord-346964-9afuen7k 174 10 epithelial epithelial JJ cord-346964-9afuen7k 174 11 damage damage NN cord-346964-9afuen7k 174 12 observed observe VBN cord-346964-9afuen7k 174 13 in in IN cord-346964-9afuen7k 174 14 CD CD NNP cord-346964-9afuen7k 174 15 , , , cord-346964-9afuen7k 174 16 although although IN cord-346964-9afuen7k 174 17 the the DT cord-346964-9afuen7k 174 18 exact exact JJ cord-346964-9afuen7k 174 19 mechanism mechanism NN cord-346964-9afuen7k 174 20 is be VBZ cord-346964-9afuen7k 174 21 still still RB cord-346964-9afuen7k 174 22 not not RB cord-346964-9afuen7k 174 23 known know VBN cord-346964-9afuen7k 174 24 . . . cord-346964-9afuen7k 175 1 The the DT cord-346964-9afuen7k 175 2 vast vast JJ cord-346964-9afuen7k 175 3 majority majority NN cord-346964-9afuen7k 175 4 of of IN cord-346964-9afuen7k 175 5 IELs iel NNS cord-346964-9afuen7k 175 6 are be VBP cord-346964-9afuen7k 175 7 T T NNP cord-346964-9afuen7k 175 8 cells cell NNS cord-346964-9afuen7k 175 9 , , , cord-346964-9afuen7k 175 10 which which WDT cord-346964-9afuen7k 175 11 are be VBP cord-346964-9afuen7k 175 12 mostly mostly RB cord-346964-9afuen7k 175 13 cytotoxic cytotoxic JJ cord-346964-9afuen7k 175 14 T t NN cord-346964-9afuen7k 175 15 cells cell NNS cord-346964-9afuen7k 175 16 expressing express VBG cord-346964-9afuen7k 175 17 ab ab NNP cord-346964-9afuen7k 175 18 TCR TCR NNP cord-346964-9afuen7k 175 19 on on IN cord-346964-9afuen7k 175 20 their -PRON- PRP$ cord-346964-9afuen7k 175 21 surface surface NN cord-346964-9afuen7k 175 22 . . . cord-346964-9afuen7k 176 1 The the DT cord-346964-9afuen7k 176 2 population population NN cord-346964-9afuen7k 176 3 specifically specifically RB cord-346964-9afuen7k 176 4 expanded expand VBD cord-346964-9afuen7k 176 5 in in IN cord-346964-9afuen7k 176 6 GSE GSE NNP cord-346964-9afuen7k 176 7 is be VBZ cord-346964-9afuen7k 176 8 the the DT cord-346964-9afuen7k 176 9 CD3 CD3 NNP cord-346964-9afuen7k 176 10 þ þ NNP cord-346964-9afuen7k 176 11 / / SYM cord-346964-9afuen7k 176 12 CD4 CD4 NNP cord-346964-9afuen7k 176 13 À/ À/ NNP cord-346964-9afuen7k 176 14 CD8 CD8 NNP cord-346964-9afuen7k 176 15 À à NN cord-346964-9afuen7k 176 16 , , , cord-346964-9afuen7k 176 17 gd gd NNP cord-346964-9afuen7k 176 18 TCR TCR NNP cord-346964-9afuen7k 176 19 - - HYPH cord-346964-9afuen7k 176 20 bearing bear VBG cord-346964-9afuen7k 176 21 IELs iel NNS cord-346964-9afuen7k 176 22 , , , cord-346964-9afuen7k 176 23 which which WDT cord-346964-9afuen7k 176 24 is be VBZ cord-346964-9afuen7k 176 25 only only RB cord-346964-9afuen7k 176 26 5 5 CD cord-346964-9afuen7k 176 27 % % NN cord-346964-9afuen7k 176 28 of of IN cord-346964-9afuen7k 176 29 the the DT cord-346964-9afuen7k 176 30 total total NN cord-346964-9afuen7k 176 31 in in IN cord-346964-9afuen7k 176 32 normal normal JJ cord-346964-9afuen7k 176 33 mucosa mucosa NN cord-346964-9afuen7k 176 34 ( ( -LRB- cord-346964-9afuen7k 176 35 Figure figure NN cord-346964-9afuen7k 176 36 9 9 CD cord-346964-9afuen7k 176 37 ( ( -LRB- cord-346964-9afuen7k 176 38 a a NN cord-346964-9afuen7k 176 39 ) ) -RRB- cord-346964-9afuen7k 176 40 and and CC cord-346964-9afuen7k 176 41 9(b 9(b CD cord-346964-9afuen7k 176 42 ) ) -RRB- cord-346964-9afuen7k 176 43 ) ) -RRB- cord-346964-9afuen7k 176 44 . . . cord-346964-9afuen7k 177 1 Currently currently RB cord-346964-9afuen7k 177 2 , , , cord-346964-9afuen7k 177 3 the the DT cord-346964-9afuen7k 177 4 normal normal JJ cord-346964-9afuen7k 177 5 upper upper JJ cord-346964-9afuen7k 177 6 limit limit NN cord-346964-9afuen7k 177 7 of of IN cord-346964-9afuen7k 177 8 IELs iel NNS cord-346964-9afuen7k 177 9 is be VBZ cord-346964-9afuen7k 177 10 accepted accept VBN cord-346964-9afuen7k 177 11 as as IN cord-346964-9afuen7k 177 12 20 20 CD cord-346964-9afuen7k 177 13 lymphocytes/100 lymphocytes/100 NNP cord-346964-9afuen7k 177 14 enterocytes enterocytes NNP cord-346964-9afuen7k 177 15 ( ( -LRB- cord-346964-9afuen7k 177 16 a a DT cord-346964-9afuen7k 177 17 ratio ratio NN cord-346964-9afuen7k 177 18 of of IN cord-346964-9afuen7k 177 19 1 1 CD cord-346964-9afuen7k 177 20 IEL IEL NNP cord-346964-9afuen7k 177 21 per per IN cord-346964-9afuen7k 177 22 5 5 CD cord-346964-9afuen7k 177 23 enterocytes enterocyte NNS cord-346964-9afuen7k 177 24 ) ) -RRB- cord-346964-9afuen7k 177 25 in in IN cord-346964-9afuen7k 177 26 H&E H&E NNP cord-346964-9afuen7k 177 27 sections section NNS cord-346964-9afuen7k 177 28 , , , cord-346964-9afuen7k 177 29 whereas whereas IN cord-346964-9afuen7k 177 30 25 25 CD cord-346964-9afuen7k 177 31 IELs/100 IELs/100 NNP cord-346964-9afuen7k 177 32 enterocytes enterocytes NNPS cord-346964-9afuen7k 177 33 ( ( -LRB- cord-346964-9afuen7k 177 34 or or CC cord-346964-9afuen7k 177 35 a a DT cord-346964-9afuen7k 177 36 ratio ratio NN cord-346964-9afuen7k 177 37 of of IN cord-346964-9afuen7k 177 38 1:4 1:4 CD cord-346964-9afuen7k 177 39 ) ) -RRB- cord-346964-9afuen7k 177 40 in in IN cord-346964-9afuen7k 177 41 CD3 CD3 NNP cord-346964-9afuen7k 177 42 immunostained immunostaine VBN cord-346964-9afuen7k 177 43 slides slide NNS cord-346964-9afuen7k 177 44 are be VBP cord-346964-9afuen7k 177 45 considered consider VBN cord-346964-9afuen7k 177 46 as as IN cord-346964-9afuen7k 177 47 the the DT cord-346964-9afuen7k 177 48 upper upper JJ cord-346964-9afuen7k 177 49 limit limit NN cord-346964-9afuen7k 177 50 of of IN cord-346964-9afuen7k 177 51 normal normal JJ cord-346964-9afuen7k 177 52 . . . cord-346964-9afuen7k 178 1 IELs iel NNS cord-346964-9afuen7k 178 2 are be VBP cord-346964-9afuen7k 178 3 active active JJ cord-346964-9afuen7k 178 4 components component NNS cord-346964-9afuen7k 178 5 of of IN cord-346964-9afuen7k 178 6 the the DT cord-346964-9afuen7k 178 7 mucosal mucosal JJ cord-346964-9afuen7k 178 8 immune immune JJ cord-346964-9afuen7k 178 9 system system NN cord-346964-9afuen7k 178 10 that that WDT cord-346964-9afuen7k 178 11 is be VBZ cord-346964-9afuen7k 178 12 under under IN cord-346964-9afuen7k 178 13 ongoing ongoing JJ cord-346964-9afuen7k 178 14 threat threat NN cord-346964-9afuen7k 178 15 from from IN cord-346964-9afuen7k 178 16 luminal luminal JJ cord-346964-9afuen7k 178 17 antigens antigen NNS cord-346964-9afuen7k 178 18 such such JJ cord-346964-9afuen7k 178 19 as as IN cord-346964-9afuen7k 178 20 gluten gluten NN cord-346964-9afuen7k 178 21 , , , cord-346964-9afuen7k 178 22 microorganisms microorganism NNS cord-346964-9afuen7k 178 23 , , , cord-346964-9afuen7k 178 24 drugs drug NNS cord-346964-9afuen7k 178 25 , , , cord-346964-9afuen7k 178 26 and and CC cord-346964-9afuen7k 178 27 other other JJ cord-346964-9afuen7k 178 28 toxic toxic JJ cord-346964-9afuen7k 178 29 molecules molecule NNS cord-346964-9afuen7k 178 30 , , , cord-346964-9afuen7k 178 31 all all DT cord-346964-9afuen7k 178 32 of of IN cord-346964-9afuen7k 178 33 which which WDT cord-346964-9afuen7k 178 34 can can MD cord-346964-9afuen7k 178 35 cause cause VB cord-346964-9afuen7k 178 36 an an DT cord-346964-9afuen7k 178 37 increase increase NN cord-346964-9afuen7k 178 38 in in IN cord-346964-9afuen7k 178 39 IELs iel NNS cord-346964-9afuen7k 178 40 . . . cord-346964-9afuen7k 179 1 Though though IN cord-346964-9afuen7k 179 2 IELosis ielosis NN cord-346964-9afuen7k 179 3 in in IN cord-346964-9afuen7k 179 4 a a DT cord-346964-9afuen7k 179 5 normal normal JJ cord-346964-9afuen7k 179 6 mucosa mucosa NN cord-346964-9afuen7k 179 7 is be VBZ cord-346964-9afuen7k 179 8 an an DT cord-346964-9afuen7k 179 9 increasingly increasingly RB cord-346964-9afuen7k 179 10 reported report VBN cord-346964-9afuen7k 179 11 pathological pathological JJ cord-346964-9afuen7k 179 12 feature feature NN cord-346964-9afuen7k 179 13 in in IN cord-346964-9afuen7k 179 14 CD CD NNP cord-346964-9afuen7k 179 15 , , , cord-346964-9afuen7k 179 16 it -PRON- PRP cord-346964-9afuen7k 179 17 is be VBZ cord-346964-9afuen7k 179 18 by by IN cord-346964-9afuen7k 179 19 no no DT cord-346964-9afuen7k 179 20 means mean NNS cord-346964-9afuen7k 179 21 diagnostic diagnostic JJ cord-346964-9afuen7k 179 22 , , , cord-346964-9afuen7k 179 23 since since IN cord-346964-9afuen7k 179 24 overlap overlap NN cord-346964-9afuen7k 179 25 in in IN cord-346964-9afuen7k 179 26 the the DT cord-346964-9afuen7k 179 27 IEL IEL NNP cord-346964-9afuen7k 179 28 counts count VBZ cord-346964-9afuen7k 179 29 occurs occur VBZ cord-346964-9afuen7k 179 30 between between IN cord-346964-9afuen7k 179 31 CD cd NN cord-346964-9afuen7k 179 32 and and CC cord-346964-9afuen7k 179 33 non non JJ cord-346964-9afuen7k 179 34 - - JJ cord-346964-9afuen7k 179 35 CD cd JJ cord-346964-9afuen7k 179 36 patients patient NNS cord-346964-9afuen7k 179 37 . . . cord-346964-9afuen7k 180 1 Various various JJ cord-346964-9afuen7k 180 2 pathological pathological JJ cord-346964-9afuen7k 180 3 processes process NNS cord-346964-9afuen7k 180 4 , , , cord-346964-9afuen7k 180 5 including include VBG cord-346964-9afuen7k 180 6 food food NN cord-346964-9afuen7k 180 7 allergies allergy NNS cord-346964-9afuen7k 180 8 other other JJ cord-346964-9afuen7k 180 9 than than IN cord-346964-9afuen7k 180 10 CD CD NNP cord-346964-9afuen7k 180 11 , , , cord-346964-9afuen7k 180 12 Helicobacter Helicobacter NNP cord-346964-9afuen7k 180 13 pylori pylori NN cord-346964-9afuen7k 180 14 - - HYPH cord-346964-9afuen7k 180 15 associated associate VBN cord-346964-9afuen7k 180 16 duodenitis duodenitis NN cord-346964-9afuen7k 180 17 , , , cord-346964-9afuen7k 180 18 giardiasis giardiasis NN cord-346964-9afuen7k 180 19 , , , cord-346964-9afuen7k 180 20 graft graft NN cord-346964-9afuen7k 180 21 - - HYPH cord-346964-9afuen7k 180 22 versus versus IN cord-346964-9afuen7k 180 23 - - HYPH cord-346964-9afuen7k 180 24 host host NN cord-346964-9afuen7k 180 25 disease disease NN cord-346964-9afuen7k 180 26 ( ( -LRB- cord-346964-9afuen7k 180 27 GVHD GVHD NNP cord-346964-9afuen7k 180 28 ) ) -RRB- cord-346964-9afuen7k 180 29 , , , cord-346964-9afuen7k 180 30 tropical tropical JJ cord-346964-9afuen7k 180 31 sprue sprue NN cord-346964-9afuen7k 180 32 , , , cord-346964-9afuen7k 180 33 viral viral JJ cord-346964-9afuen7k 180 34 enteritis enteritis NN cord-346964-9afuen7k 180 35 , , , cord-346964-9afuen7k 180 36 nonsteroidal nonsteroidal JJ cord-346964-9afuen7k 180 37 anti anti JJ cord-346964-9afuen7k 180 38 - - JJ cord-346964-9afuen7k 180 39 inflammatory inflammatory JJ cord-346964-9afuen7k 180 40 drug drug NN cord-346964-9afuen7k 180 41 ( ( -LRB- cord-346964-9afuen7k 180 42 NSAID NSAID NNP cord-346964-9afuen7k 180 43 ) ) -RRB- cord-346964-9afuen7k 180 44 injury injury NN cord-346964-9afuen7k 180 45 , , , cord-346964-9afuen7k 180 46 chemoradiotherapy chemoradiotherapy NN cord-346964-9afuen7k 180 47 - - HYPH cord-346964-9afuen7k 180 48 induced induce VBN cord-346964-9afuen7k 180 49 enteritis enteritis NN cord-346964-9afuen7k 180 50 , , , cord-346964-9afuen7k 180 51 autoimmune autoimmune JJ cord-346964-9afuen7k 180 52 enteropathy enteropathy NNP cord-346964-9afuen7k 180 53 , , , cord-346964-9afuen7k 180 54 immunodeficiencies immunodeficiency NNS cord-346964-9afuen7k 180 55 , , , cord-346964-9afuen7k 180 56 and and CC cord-346964-9afuen7k 180 57 Crohn Crohn NNP cord-346964-9afuen7k 180 58 's 's POS cord-346964-9afuen7k 180 59 disease disease NN cord-346964-9afuen7k 180 60 , , , cord-346964-9afuen7k 180 61 can can MD cord-346964-9afuen7k 180 62 induce induce VB cord-346964-9afuen7k 180 63 IELosis ielosis NN cord-346964-9afuen7k 180 64 with with IN cord-346964-9afuen7k 180 65 or or CC cord-346964-9afuen7k 180 66 without without IN cord-346964-9afuen7k 180 67 associated associate VBN cord-346964-9afuen7k 180 68 architectural architectural JJ cord-346964-9afuen7k 180 69 changes change NNS cord-346964-9afuen7k 180 70 . . . cord-346964-9afuen7k 181 1 Entities entity NNS cord-346964-9afuen7k 181 2 causing cause VBG cord-346964-9afuen7k 181 3 IELosis ielosis NN cord-346964-9afuen7k 181 4 and and CC cord-346964-9afuen7k 181 5 flat flat JJ cord-346964-9afuen7k 181 6 mucosa mucosa NNS cord-346964-9afuen7k 181 7 are be VBP cord-346964-9afuen7k 181 8 listed list VBN cord-346964-9afuen7k 181 9 in in IN cord-346964-9afuen7k 181 10 Table Table NNP cord-346964-9afuen7k 181 11 4 4 CD cord-346964-9afuen7k 181 12 . . . cord-346964-9afuen7k 181 13 _SP cord-346964-9afuen7k 182 1 Refractory refractory JJ cord-346964-9afuen7k 182 2 sprue sprue NN cord-346964-9afuen7k 182 3 comprises comprise VBZ cord-346964-9afuen7k 182 4 patients patient NNS cord-346964-9afuen7k 182 5 with with IN cord-346964-9afuen7k 182 6 incomplete incomplete JJ cord-346964-9afuen7k 182 7 or or CC cord-346964-9afuen7k 182 8 no no DT cord-346964-9afuen7k 182 9 response response NN cord-346964-9afuen7k 182 10 to to IN cord-346964-9afuen7k 182 11 GFD GFD NNP cord-346964-9afuen7k 182 12 for for IN cord-346964-9afuen7k 182 13 at at RB cord-346964-9afuen7k 182 14 least least RBS cord-346964-9afuen7k 182 15 6 6 CD cord-346964-9afuen7k 182 16 months month NNS cord-346964-9afuen7k 182 17 . . . cord-346964-9afuen7k 183 1 Histopathologically histopathologically RB cord-346964-9afuen7k 183 2 , , , cord-346964-9afuen7k 183 3 most most JJS cord-346964-9afuen7k 183 4 cases case NNS cord-346964-9afuen7k 183 5 with with IN cord-346964-9afuen7k 183 6 refractory refractory JJ cord-346964-9afuen7k 183 7 sprue sprue NN cord-346964-9afuen7k 183 8 show show NN cord-346964-9afuen7k 183 9 flat flat JJ cord-346964-9afuen7k 183 10 or or CC cord-346964-9afuen7k 183 11 near near IN cord-346964-9afuen7k 183 12 flat flat JJ cord-346964-9afuen7k 183 13 mucosa mucosa RB cord-346964-9afuen7k 183 14 with with IN cord-346964-9afuen7k 183 15 a a DT cord-346964-9afuen7k 183 16 dense dense JJ cord-346964-9afuen7k 183 17 mononuclear mononuclear JJ cord-346964-9afuen7k 183 18 infiltrate infiltrate NN cord-346964-9afuen7k 183 19 of of IN cord-346964-9afuen7k 183 20 mainly mainly RB cord-346964-9afuen7k 183 21 plasma plasma NN cord-346964-9afuen7k 183 22 cells cell NNS cord-346964-9afuen7k 183 23 and and CC cord-346964-9afuen7k 183 24 lymphocytes lymphocyte NNS cord-346964-9afuen7k 183 25 in in IN cord-346964-9afuen7k 183 26 the the DT cord-346964-9afuen7k 183 27 lamina lamina JJ cord-346964-9afuen7k 183 28 propria propria NN cord-346964-9afuen7k 183 29 and and CC cord-346964-9afuen7k 183 30 a a DT cord-346964-9afuen7k 183 31 massive massive JJ cord-346964-9afuen7k 183 32 increase increase NN cord-346964-9afuen7k 183 33 in in IN cord-346964-9afuen7k 183 34 IELs iel NNS cord-346964-9afuen7k 183 35 . . . cord-346964-9afuen7k 184 1 The the DT cord-346964-9afuen7k 184 2 lymphocytes lymphocyte NNS cord-346964-9afuen7k 184 3 in in IN cord-346964-9afuen7k 184 4 the the DT cord-346964-9afuen7k 184 5 villous villous NN cord-346964-9afuen7k 184 6 , , , cord-346964-9afuen7k 184 7 crypt crypt JJ cord-346964-9afuen7k 184 8 epithelium epithelium NN cord-346964-9afuen7k 184 9 , , , cord-346964-9afuen7k 184 10 and and CC cord-346964-9afuen7k 184 11 lamina lamina NN cord-346964-9afuen7k 184 12 propria propria NNP cord-346964-9afuen7k 184 13 are be VBP cord-346964-9afuen7k 184 14 normal normal JJ cord-346964-9afuen7k 184 15 to to TO cord-346964-9afuen7k 184 16 medium medium NN cord-346964-9afuen7k 184 17 in in IN cord-346964-9afuen7k 184 18 size size NN cord-346964-9afuen7k 184 19 with with IN cord-346964-9afuen7k 184 20 a a DT cord-346964-9afuen7k 184 21 normal normal JJ cord-346964-9afuen7k 184 22 cytological cytological JJ cord-346964-9afuen7k 184 23 appearance appearance NN cord-346964-9afuen7k 184 24 . . . cord-346964-9afuen7k 185 1 However however RB cord-346964-9afuen7k 185 2 , , , cord-346964-9afuen7k 185 3 refractory refractory JJ cord-346964-9afuen7k 185 4 sprue sprue NN cord-346964-9afuen7k 185 5 can can MD cord-346964-9afuen7k 185 6 be be VB cord-346964-9afuen7k 185 7 divided divide VBN cord-346964-9afuen7k 185 8 into into IN cord-346964-9afuen7k 185 9 two two CD cord-346964-9afuen7k 185 10 subtypes subtype NNS cord-346964-9afuen7k 185 11 by by IN cord-346964-9afuen7k 185 12 means mean NNS cord-346964-9afuen7k 185 13 of of IN cord-346964-9afuen7k 185 14 T t NN cord-346964-9afuen7k 185 15 - - HYPH cord-346964-9afuen7k 185 16 cell cell NN cord-346964-9afuen7k 185 17 clonality clonality NN cord-346964-9afuen7k 185 18 : : : cord-346964-9afuen7k 186 1 type type NN cord-346964-9afuen7k 186 2 1 1 CD cord-346964-9afuen7k 186 3 refers refer VBZ cord-346964-9afuen7k 186 4 to to IN cord-346964-9afuen7k 186 5 cases case NNS cord-346964-9afuen7k 186 6 with with IN cord-346964-9afuen7k 186 7 no no DT cord-346964-9afuen7k 186 8 clonality clonality NN cord-346964-9afuen7k 186 9 on on IN cord-346964-9afuen7k 186 10 TCR TCR NNP cord-346964-9afuen7k 186 11 gene gene NN cord-346964-9afuen7k 186 12 rearrangements rearrangement NNS cord-346964-9afuen7k 186 13 and and CC cord-346964-9afuen7k 186 14 CD3 cd3 NN cord-346964-9afuen7k 186 15 þ þ NNP cord-346964-9afuen7k 186 16 CD8þ CD8þ NNP cord-346964-9afuen7k 186 17 phenotype phenotype NN cord-346964-9afuen7k 186 18 , , , cord-346964-9afuen7k 186 19 while while IN cord-346964-9afuen7k 186 20 type type NN cord-346964-9afuen7k 186 21 2 2 CD cord-346964-9afuen7k 186 22 comprises comprise VBZ cord-346964-9afuen7k 186 23 cases case NNS cord-346964-9afuen7k 186 24 with with IN cord-346964-9afuen7k 186 25 CD3 CD3 NNP cord-346964-9afuen7k 186 26 þ þ NNP cord-346964-9afuen7k 186 27 CD8 CD8 NNP cord-346964-9afuen7k 186 28 À à IN cord-346964-9afuen7k 186 29 phenotype phenotype NN cord-346964-9afuen7k 186 30 and and CC cord-346964-9afuen7k 186 31 showing show VBG cord-346964-9afuen7k 186 32 clonal clonal JJ cord-346964-9afuen7k 186 33 expansions expansion NNS cord-346964-9afuen7k 186 34 proved prove VBN cord-346964-9afuen7k 186 35 by by IN cord-346964-9afuen7k 186 36 monoclonal monoclonal JJ cord-346964-9afuen7k 186 37 rearrangements rearrangement NNS cord-346964-9afuen7k 186 38 of of IN cord-346964-9afuen7k 186 39 the the DT cord-346964-9afuen7k 186 40 TCRgd TCRgd NNP cord-346964-9afuen7k 186 41 gene gene NN cord-346964-9afuen7k 186 42 . . . cord-346964-9afuen7k 187 1 These these DT cord-346964-9afuen7k 187 2 features feature NNS cord-346964-9afuen7k 187 3 have have VBP cord-346964-9afuen7k 187 4 led lead VBN cord-346964-9afuen7k 187 5 to to IN cord-346964-9afuen7k 187 6 the the DT cord-346964-9afuen7k 187 7 idea idea NN cord-346964-9afuen7k 187 8 that that IN cord-346964-9afuen7k 187 9 these these DT cord-346964-9afuen7k 187 10 cases case NNS cord-346964-9afuen7k 187 11 represent represent VBP cord-346964-9afuen7k 187 12 a a DT cord-346964-9afuen7k 187 13 form form NN cord-346964-9afuen7k 187 14 of of IN cord-346964-9afuen7k 187 15 in in IN cord-346964-9afuen7k 187 16 situ situ NN cord-346964-9afuen7k 187 17 or or CC cord-346964-9afuen7k 187 18 ' ' `` cord-346964-9afuen7k 187 19 cryptic cryptic JJ cord-346964-9afuen7k 187 20 ' ' '' cord-346964-9afuen7k 187 21 T t NN cord-346964-9afuen7k 187 22 - - HYPH cord-346964-9afuen7k 187 23 cell cell NN cord-346964-9afuen7k 187 24 lymphoma lymphoma NN cord-346964-9afuen7k 187 25 . . . cord-346964-9afuen7k 188 1 Collagenous collagenous JJ cord-346964-9afuen7k 188 2 sprue sprue NN cord-346964-9afuen7k 188 3 refers refer VBZ cord-346964-9afuen7k 188 4 to to IN cord-346964-9afuen7k 188 5 a a DT cord-346964-9afuen7k 188 6 variant variant JJ cord-346964-9afuen7k 188 7 entity entity NN cord-346964-9afuen7k 188 8 having have VBG cord-346964-9afuen7k 188 9 a a DT cord-346964-9afuen7k 188 10 thick thick JJ cord-346964-9afuen7k 188 11 collagen collagen NN cord-346964-9afuen7k 188 12 table table NN cord-346964-9afuen7k 188 13 beneath beneath IN cord-346964-9afuen7k 188 14 the the DT cord-346964-9afuen7k 188 15 surface surface NN cord-346964-9afuen7k 188 16 epithelium epithelium NN cord-346964-9afuen7k 188 17 of of IN cord-346964-9afuen7k 188 18 a a DT cord-346964-9afuen7k 188 19 mucosa mucosa NN cord-346964-9afuen7k 188 20 that that WDT cord-346964-9afuen7k 188 21 also also RB cord-346964-9afuen7k 188 22 has have VBZ cord-346964-9afuen7k 188 23 other other JJ cord-346964-9afuen7k 188 24 typical typical JJ cord-346964-9afuen7k 188 25 features feature NNS cord-346964-9afuen7k 188 26 of of IN cord-346964-9afuen7k 188 27 CD cd NN cord-346964-9afuen7k 188 28 , , , cord-346964-9afuen7k 188 29 including include VBG cord-346964-9afuen7k 188 30 IELosis ielosis NN cord-346964-9afuen7k 188 31 and and CC cord-346964-9afuen7k 188 32 flat flat JJ cord-346964-9afuen7k 188 33 mucosa mucosa NN cord-346964-9afuen7k 188 34 . . . cord-346964-9afuen7k 189 1 Enteropathy Enteropathy NNP cord-346964-9afuen7k 189 2 - - HYPH cord-346964-9afuen7k 189 3 induced induce VBN cord-346964-9afuen7k 189 4 T t NN cord-346964-9afuen7k 189 5 - - HYPH cord-346964-9afuen7k 189 6 cell cell NN cord-346964-9afuen7k 189 7 lymphoma lymphoma NN cord-346964-9afuen7k 189 8 ( ( -LRB- cord-346964-9afuen7k 189 9 EITCL EITCL NNP cord-346964-9afuen7k 189 10 ) ) -RRB- cord-346964-9afuen7k 189 11 is be VBZ cord-346964-9afuen7k 189 12 the the DT cord-346964-9afuen7k 189 13 most most RBS cord-346964-9afuen7k 189 14 fearsome fearsome JJ cord-346964-9afuen7k 189 15 complication complication NN cord-346964-9afuen7k 189 16 of of IN cord-346964-9afuen7k 189 17 CD cd NN cord-346964-9afuen7k 189 18 in in IN cord-346964-9afuen7k 189 19 patients patient NNS cord-346964-9afuen7k 189 20 with with IN cord-346964-9afuen7k 189 21 long long RB cord-346964-9afuen7k 189 22 - - HYPH cord-346964-9afuen7k 189 23 standing stand VBG cord-346964-9afuen7k 189 24 malabsorption malabsorption NN cord-346964-9afuen7k 189 25 . . . cord-346964-9afuen7k 190 1 They -PRON- PRP cord-346964-9afuen7k 190 2 usually usually RB cord-346964-9afuen7k 190 3 suffer suffer VBP cord-346964-9afuen7k 190 4 from from IN cord-346964-9afuen7k 190 5 severe severe JJ cord-346964-9afuen7k 190 6 malabsorption malabsorption NN cord-346964-9afuen7k 190 7 refractory refractory JJ cord-346964-9afuen7k 190 8 to to IN cord-346964-9afuen7k 190 9 GFD GFD NNP cord-346964-9afuen7k 190 10 , , , cord-346964-9afuen7k 190 11 causing cause VBG cord-346964-9afuen7k 190 12 weight weight NN cord-346964-9afuen7k 190 13 loss loss NN cord-346964-9afuen7k 190 14 and and CC cord-346964-9afuen7k 190 15 complications complication NNS cord-346964-9afuen7k 190 16 such such JJ cord-346964-9afuen7k 190 17 as as IN cord-346964-9afuen7k 190 18 perforations perforation NNS cord-346964-9afuen7k 190 19 and and CC cord-346964-9afuen7k 190 20 bleeding bleed VBG cord-346964-9afuen7k 190 21 due due IN cord-346964-9afuen7k 190 22 to to IN cord-346964-9afuen7k 190 23 ulcerative ulcerative JJ cord-346964-9afuen7k 190 24 lesions lesion NNS cord-346964-9afuen7k 190 25 . . . cord-346964-9afuen7k 191 1 Histopathologically histopathologically RB cord-346964-9afuen7k 191 2 , , , cord-346964-9afuen7k 191 3 the the DT cord-346964-9afuen7k 191 4 mucosa mucosa NN cord-346964-9afuen7k 191 5 is be VBZ cord-346964-9afuen7k 191 6 flat flat JJ cord-346964-9afuen7k 191 7 with with IN cord-346964-9afuen7k 191 8 ulcerations ulceration NNS cord-346964-9afuen7k 191 9 and and CC cord-346964-9afuen7k 191 10 crypt crypt NN cord-346964-9afuen7k 191 11 hypoplasia hypoplasia NN cord-346964-9afuen7k 191 12 together together RB cord-346964-9afuen7k 191 13 with with IN cord-346964-9afuen7k 191 14 an an DT cord-346964-9afuen7k 191 15 atypical atypical JJ cord-346964-9afuen7k 191 16 population population NN cord-346964-9afuen7k 191 17 of of IN cord-346964-9afuen7k 191 18 neoplastic neoplastic JJ cord-346964-9afuen7k 191 19 lymphocytes lymphocyte NNS cord-346964-9afuen7k 191 20 infiltrates infiltrate VBZ cord-346964-9afuen7k 191 21 the the DT cord-346964-9afuen7k 191 22 mucosa mucosa NN cord-346964-9afuen7k 191 23 . . . cord-346964-9afuen7k 192 1 Lymphoma lymphoma NN cord-346964-9afuen7k 192 2 cells cell NNS cord-346964-9afuen7k 192 3 are be VBP cord-346964-9afuen7k 192 4 pleomorphic pleomorphic JJ cord-346964-9afuen7k 192 5 large large JJ cord-346964-9afuen7k 192 6 cells cell NNS cord-346964-9afuen7k 192 7 that that WDT cord-346964-9afuen7k 192 8 are be VBP cord-346964-9afuen7k 192 9 double double JJ cord-346964-9afuen7k 192 10 - - HYPH cord-346964-9afuen7k 192 11 negative negative JJ cord-346964-9afuen7k 193 1 ( ( -LRB- cord-346964-9afuen7k 193 2 CD8 CD8 NNP cord-346964-9afuen7k 193 3 À À NNP cord-346964-9afuen7k 193 4 and and CC cord-346964-9afuen7k 193 5 CD4 CD4 NNP cord-346964-9afuen7k 193 6 À À NNP cord-346964-9afuen7k 193 7 ) ) -RRB- cord-346964-9afuen7k 193 8 with with IN cord-346964-9afuen7k 193 9 cell cell NN cord-346964-9afuen7k 193 10 surface surface NN cord-346964-9afuen7k 193 11 markers marker NNS cord-346964-9afuen7k 193 12 but but CC cord-346964-9afuen7k 193 13 are be VBP cord-346964-9afuen7k 193 14 almost almost RB cord-346964-9afuen7k 193 15 always always RB cord-346964-9afuen7k 193 16 positive positive JJ cord-346964-9afuen7k 193 17 with with IN cord-346964-9afuen7k 193 18 CD30 CD30 NNP cord-346964-9afuen7k 193 19 that that WDT cord-346964-9afuen7k 193 20 is be VBZ cord-346964-9afuen7k 193 21 also also RB cord-346964-9afuen7k 193 22 associated associate VBN cord-346964-9afuen7k 193 23 with with IN cord-346964-9afuen7k 193 24 poor poor JJ cord-346964-9afuen7k 193 25 prognosis prognosis NN cord-346964-9afuen7k 193 26 . . . cord-346964-9afuen7k 194 1 This this DT cord-346964-9afuen7k 194 2 is be VBZ cord-346964-9afuen7k 194 3 a a DT cord-346964-9afuen7k 194 4 rare rare JJ cord-346964-9afuen7k 194 5 disorder disorder NN cord-346964-9afuen7k 194 6 of of IN cord-346964-9afuen7k 194 7 unknown unknown JJ cord-346964-9afuen7k 194 8 etiology etiology NN cord-346964-9afuen7k 194 9 , , , cord-346964-9afuen7k 194 10 mainly mainly RB cord-346964-9afuen7k 194 11 occurring occur VBG cord-346964-9afuen7k 194 12 among among IN cord-346964-9afuen7k 194 13 the the DT cord-346964-9afuen7k 194 14 individuals individual NNS cord-346964-9afuen7k 194 15 living live VBG cord-346964-9afuen7k 194 16 in in IN cord-346964-9afuen7k 194 17 or or CC cord-346964-9afuen7k 194 18 visiting visit VBG cord-346964-9afuen7k 194 19 the the DT cord-346964-9afuen7k 194 20 tropical tropical JJ cord-346964-9afuen7k 194 21 countries country NNS cord-346964-9afuen7k 194 22 . . . cord-346964-9afuen7k 195 1 Tropical tropical JJ cord-346964-9afuen7k 195 2 sprue sprue NN cord-346964-9afuen7k 195 3 results result VBZ cord-346964-9afuen7k 195 4 from from IN cord-346964-9afuen7k 195 5 a a DT cord-346964-9afuen7k 195 6 nutritional nutritional JJ cord-346964-9afuen7k 195 7 deficiency deficiency NN cord-346964-9afuen7k 195 8 or or CC cord-346964-9afuen7k 195 9 a a DT cord-346964-9afuen7k 195 10 transmissible transmissible JJ cord-346964-9afuen7k 195 11 microorganism microorganism NN cord-346964-9afuen7k 195 12 and/or and/or CC cord-346964-9afuen7k 195 13 a a DT cord-346964-9afuen7k 195 14 toxin toxin NN cord-346964-9afuen7k 195 15 . . . cord-346964-9afuen7k 196 1 Malabsorption malabsorption NN cord-346964-9afuen7k 196 2 is be VBZ cord-346964-9afuen7k 196 3 usually usually RB cord-346964-9afuen7k 196 4 initiated initiate VBN cord-346964-9afuen7k 196 5 by by IN cord-346964-9afuen7k 196 6 an an DT cord-346964-9afuen7k 196 7 infection infection NN cord-346964-9afuen7k 196 8 followed follow VBN cord-346964-9afuen7k 196 9 by by IN cord-346964-9afuen7k 196 10 colonization colonization NN cord-346964-9afuen7k 196 11 of of IN cord-346964-9afuen7k 196 12 the the DT cord-346964-9afuen7k 196 13 small small JJ cord-346964-9afuen7k 196 14 bowel bowel NN cord-346964-9afuen7k 196 15 by by IN cord-346964-9afuen7k 196 16 enterotoxigenic enterotoxigenic JJ cord-346964-9afuen7k 196 17 bacteria bacteria NNS cord-346964-9afuen7k 196 18 . . . cord-346964-9afuen7k 197 1 Despite despite IN cord-346964-9afuen7k 197 2 the the DT cord-346964-9afuen7k 197 3 fact fact NN cord-346964-9afuen7k 197 4 that that IN cord-346964-9afuen7k 197 5 a a DT cord-346964-9afuen7k 197 6 single single JJ cord-346964-9afuen7k 197 7 etiologic etiologic JJ cord-346964-9afuen7k 197 8 agent agent NN cord-346964-9afuen7k 197 9 has have VBZ cord-346964-9afuen7k 197 10 not not RB cord-346964-9afuen7k 197 11 been be VBN cord-346964-9afuen7k 197 12 identified identify VBN cord-346964-9afuen7k 197 13 , , , cord-346964-9afuen7k 197 14 there there EX cord-346964-9afuen7k 197 15 is be VBZ cord-346964-9afuen7k 197 16 much much JJ cord-346964-9afuen7k 197 17 evidence evidence NN cord-346964-9afuen7k 197 18 that that IN cord-346964-9afuen7k 197 19 an an DT cord-346964-9afuen7k 197 20 infection infection NN cord-346964-9afuen7k 197 21 initiates initiate VBZ cord-346964-9afuen7k 197 22 and and CC cord-346964-9afuen7k 197 23 sustains sustain VBZ cord-346964-9afuen7k 197 24 tropical tropical JJ cord-346964-9afuen7k 197 25 sprue sprue NN cord-346964-9afuen7k 197 26 : : : cord-346964-9afuen7k 198 1 ( ( -LRB- cord-346964-9afuen7k 198 2 a a LS cord-346964-9afuen7k 198 3 ) ) -RRB- cord-346964-9afuen7k 199 1 It -PRON- PRP cord-346964-9afuen7k 199 2 occurs occur VBZ cord-346964-9afuen7k 199 3 in in IN cord-346964-9afuen7k 199 4 certain certain JJ cord-346964-9afuen7k 199 5 specific specific JJ cord-346964-9afuen7k 199 6 geographic geographic JJ cord-346964-9afuen7k 199 7 areas area NNS cord-346964-9afuen7k 199 8 ( ( -LRB- cord-346964-9afuen7k 199 9 e.g. e.g. RB cord-346964-9afuen7k 199 10 , , , cord-346964-9afuen7k 199 11 West West NNP cord-346964-9afuen7k 199 12 Indies Indies NNPS cord-346964-9afuen7k 199 13 and and CC cord-346964-9afuen7k 199 14 Indian indian JJ cord-346964-9afuen7k 199 15 subcontinent subcontinent NN cord-346964-9afuen7k 199 16 ) ) -RRB- cord-346964-9afuen7k 199 17 and and CC cord-346964-9afuen7k 199 18 enteric enteric JJ cord-346964-9afuen7k 199 19 infections infection NNS cord-346964-9afuen7k 199 20 are be VBP cord-346964-9afuen7k 199 21 common common JJ cord-346964-9afuen7k 199 22 in in IN cord-346964-9afuen7k 199 23 these these DT cord-346964-9afuen7k 199 24 locations location NNS cord-346964-9afuen7k 199 25 . . . cord-346964-9afuen7k 200 1 ( ( -LRB- cord-346964-9afuen7k 200 2 b b NN cord-346964-9afuen7k 200 3 ) ) -RRB- cord-346964-9afuen7k 201 1 In in IN cord-346964-9afuen7k 201 2 some some DT cord-346964-9afuen7k 201 3 areas area NNS cord-346964-9afuen7k 201 4 , , , cord-346964-9afuen7k 201 5 it -PRON- PRP cord-346964-9afuen7k 201 6 is be VBZ cord-346964-9afuen7k 201 7 epidemic epidemic JJ cord-346964-9afuen7k 201 8 . . . cord-346964-9afuen7k 202 1 ( ( -LRB- cord-346964-9afuen7k 202 2 c c LS cord-346964-9afuen7k 202 3 ) ) -RRB- cord-346964-9afuen7k 202 4 Aerobic aerobic JJ cord-346964-9afuen7k 202 5 enterobacteria enterobacteria NNS cord-346964-9afuen7k 202 6 colonize colonize VBP cord-346964-9afuen7k 202 7 the the DT cord-346964-9afuen7k 202 8 patient patient NN cord-346964-9afuen7k 202 9 's 's POS cord-346964-9afuen7k 202 10 small small JJ cord-346964-9afuen7k 202 11 intestine intestine NN cord-346964-9afuen7k 202 12 and and CC cord-346964-9afuen7k 202 13 these these DT cord-346964-9afuen7k 202 14 may may MD cord-346964-9afuen7k 202 15 be be VB cord-346964-9afuen7k 202 16 toxin toxin NN cord-346964-9afuen7k 202 17 - - HYPH cord-346964-9afuen7k 202 18 producing produce VBG cord-346964-9afuen7k 202 19 ( ( -LRB- cord-346964-9afuen7k 202 20 note note VB cord-346964-9afuen7k 202 21 that that IN cord-346964-9afuen7k 202 22 this this DT cord-346964-9afuen7k 202 23 differs differ VBZ cord-346964-9afuen7k 202 24 from from IN cord-346964-9afuen7k 202 25 the the DT cord-346964-9afuen7k 202 26 stasis stasis NN cord-346964-9afuen7k 202 27 syndrome syndrome NN cord-346964-9afuen7k 202 28 in in IN cord-346964-9afuen7k 202 29 which which WDT cord-346964-9afuen7k 202 30 anaerobic anaerobic JJ cord-346964-9afuen7k 202 31 bacterial bacterial JJ cord-346964-9afuen7k 202 32 overgrowth overgrowth NN cord-346964-9afuen7k 202 33 is be VBZ cord-346964-9afuen7k 202 34 central central JJ cord-346964-9afuen7k 202 35 ( ( -LRB- cord-346964-9afuen7k 202 36 see see VB cord-346964-9afuen7k 202 37 in in IN cord-346964-9afuen7k 202 38 the the DT cord-346964-9afuen7k 202 39 succeeding succeed VBG cord-346964-9afuen7k 202 40 text text NN cord-346964-9afuen7k 202 41 ) ) -RRB- cord-346964-9afuen7k 202 42 ) ) -RRB- cord-346964-9afuen7k 202 43 . . . cord-346964-9afuen7k 203 1 ( ( -LRB- cord-346964-9afuen7k 203 2 d d LS cord-346964-9afuen7k 203 3 ) ) -RRB- cord-346964-9afuen7k 203 4 Recovery recovery NN cord-346964-9afuen7k 203 5 after after IN cord-346964-9afuen7k 203 6 treating treat VBG cord-346964-9afuen7k 203 7 tropical tropical JJ cord-346964-9afuen7k 203 8 sprue sprue NN cord-346964-9afuen7k 203 9 with with IN cord-346964-9afuen7k 203 10 broad broad JJ cord-346964-9afuen7k 203 11 - - HYPH cord-346964-9afuen7k 203 12 spectrum spectrum NN cord-346964-9afuen7k 203 13 antibiotics antibiotic NNS cord-346964-9afuen7k 203 14 is be VBZ cord-346964-9afuen7k 203 15 usually usually RB cord-346964-9afuen7k 203 16 rapid rapid JJ cord-346964-9afuen7k 203 17 and and CC cord-346964-9afuen7k 203 18 dramatic dramatic JJ cord-346964-9afuen7k 203 19 . . . cord-346964-9afuen7k 204 1 ( ( -LRB- cord-346964-9afuen7k 204 2 e e LS cord-346964-9afuen7k 204 3 ) ) -RRB- cord-346964-9afuen7k 205 1 Some some DT cord-346964-9afuen7k 205 2 have have VBP cord-346964-9afuen7k 205 3 postulated postulate VBN cord-346964-9afuen7k 205 4 that that IN cord-346964-9afuen7k 205 5 a a DT cord-346964-9afuen7k 205 6 protozoan protozoan NN cord-346964-9afuen7k 205 7 infection infection NN cord-346964-9afuen7k 205 8 such such JJ cord-346964-9afuen7k 205 9 as as IN cord-346964-9afuen7k 205 10 Cyclospora Cyclospora NNP cord-346964-9afuen7k 205 11 may may MD cord-346964-9afuen7k 205 12 play play VB cord-346964-9afuen7k 205 13 a a DT cord-346964-9afuen7k 205 14 role role NN cord-346964-9afuen7k 205 15 . . . cord-346964-9afuen7k 206 1 The the DT cord-346964-9afuen7k 206 2 entire entire JJ cord-346964-9afuen7k 206 3 small small JJ cord-346964-9afuen7k 206 4 intestine intestine NN cord-346964-9afuen7k 206 5 including include VBG cord-346964-9afuen7k 206 6 the the DT cord-346964-9afuen7k 206 7 ileum ileum NN cord-346964-9afuen7k 206 8 is be VBZ cord-346964-9afuen7k 206 9 involved involve VBN cord-346964-9afuen7k 206 10 with with IN cord-346964-9afuen7k 206 11 equal equal JJ cord-346964-9afuen7k 206 12 severity severity NN cord-346964-9afuen7k 206 13 in in IN cord-346964-9afuen7k 206 14 tropical tropical JJ cord-346964-9afuen7k 206 15 sprue sprue NN cord-346964-9afuen7k 206 16 , , , cord-346964-9afuen7k 206 17 causing cause VBG cord-346964-9afuen7k 206 18 vitamin vitamin NN cord-346964-9afuen7k 206 19 B12 b12 NN cord-346964-9afuen7k 206 20 and and CC cord-346964-9afuen7k 206 21 folate folate NN cord-346964-9afuen7k 206 22 deficiencies deficiency NNS cord-346964-9afuen7k 206 23 resulting result VBG cord-346964-9afuen7k 206 24 in in IN cord-346964-9afuen7k 206 25 megaloblastic megaloblastic JJ cord-346964-9afuen7k 206 26 change change NN cord-346964-9afuen7k 206 27 in in IN cord-346964-9afuen7k 206 28 the the DT cord-346964-9afuen7k 206 29 crypt crypt JJ cord-346964-9afuen7k 206 30 epithelial epithelial JJ cord-346964-9afuen7k 206 31 cells cell NNS cord-346964-9afuen7k 206 32 . . . cord-346964-9afuen7k 207 1 The the DT cord-346964-9afuen7k 207 2 mucosal mucosal JJ cord-346964-9afuen7k 207 3 lesion lesion NN cord-346964-9afuen7k 207 4 is be VBZ cord-346964-9afuen7k 207 5 similar similar JJ cord-346964-9afuen7k 207 6 to to IN cord-346964-9afuen7k 207 7 CD CD NNP cord-346964-9afuen7k 207 8 with with IN cord-346964-9afuen7k 207 9 varying vary VBG cord-346964-9afuen7k 207 10 degree degree NN cord-346964-9afuen7k 207 11 of of IN cord-346964-9afuen7k 207 12 villous villous JJ cord-346964-9afuen7k 207 13 blunting blunting NN cord-346964-9afuen7k 207 14 , , , cord-346964-9afuen7k 207 15 though though IN cord-346964-9afuen7k 207 16 completely completely RB cord-346964-9afuen7k 207 17 flat flat JJ cord-346964-9afuen7k 207 18 mucosa mucosa NN cord-346964-9afuen7k 207 19 is be VBZ cord-346964-9afuen7k 207 20 rare rare JJ cord-346964-9afuen7k 207 21 . . . cord-346964-9afuen7k 208 1 Increase increase VB cord-346964-9afuen7k 208 2 in in IN cord-346964-9afuen7k 208 3 lamina lamina JJ cord-346964-9afuen7k 208 4 propria propria FW cord-346964-9afuen7k 208 5 lymphocytes lymphocyte NNS cord-346964-9afuen7k 208 6 , , , cord-346964-9afuen7k 208 7 plasma plasma NN cord-346964-9afuen7k 208 8 cells cell NNS cord-346964-9afuen7k 208 9 , , , cord-346964-9afuen7k 208 10 neutrophils neutrophil NNS cord-346964-9afuen7k 208 11 , , , cord-346964-9afuen7k 208 12 and and CC cord-346964-9afuen7k 208 13 eosinophils eosinophils NN cord-346964-9afuen7k 208 14 as as RB cord-346964-9afuen7k 208 15 well well RB cord-346964-9afuen7k 208 16 as as IN cord-346964-9afuen7k 208 17 IELs iel NNS cord-346964-9afuen7k 208 18 that that WDT cord-346964-9afuen7k 208 19 are be VBP cord-346964-9afuen7k 208 20 more more RBR cord-346964-9afuen7k 208 21 prominent prominent JJ cord-346964-9afuen7k 208 22 in in IN cord-346964-9afuen7k 208 23 the the DT cord-346964-9afuen7k 208 24 crypts crypt NNS cord-346964-9afuen7k 208 25 than than IN cord-346964-9afuen7k 208 26 the the DT cord-346964-9afuen7k 208 27 surface surface NN cord-346964-9afuen7k 208 28 epithelium epithelium NN cord-346964-9afuen7k 208 29 is be VBZ cord-346964-9afuen7k 208 30 usually usually RB cord-346964-9afuen7k 208 31 present present JJ cord-346964-9afuen7k 208 32 . . . cord-346964-9afuen7k 209 1 Upper upper JJ cord-346964-9afuen7k 209 2 GI GI NNP cord-346964-9afuen7k 209 3 involvement involvement NN cord-346964-9afuen7k 209 4 in in IN cord-346964-9afuen7k 209 5 IBD IBD NNP cord-346964-9afuen7k 209 6 has have VBZ cord-346964-9afuen7k 209 7 been be VBN cord-346964-9afuen7k 209 8 increasingly increasingly RB cord-346964-9afuen7k 209 9 reported report VBN cord-346964-9afuen7k 209 10 in in IN cord-346964-9afuen7k 209 11 the the DT cord-346964-9afuen7k 209 12 past past JJ cord-346964-9afuen7k 209 13 years year NNS cord-346964-9afuen7k 209 14 . . . cord-346964-9afuen7k 210 1 Both both DT cord-346964-9afuen7k 210 2 Crohn Crohn NNP cord-346964-9afuen7k 210 3 's 's POS cord-346964-9afuen7k 210 4 disease disease NN cord-346964-9afuen7k 210 5 and and CC cord-346964-9afuen7k 210 6 ulcerative ulcerative JJ cord-346964-9afuen7k 210 7 colitis colitis NN cord-346964-9afuen7k 210 8 may may MD cord-346964-9afuen7k 210 9 indeed indeed RB cord-346964-9afuen7k 210 10 affect affect VB cord-346964-9afuen7k 210 11 the the DT cord-346964-9afuen7k 210 12 upper upper JJ cord-346964-9afuen7k 210 13 GI gi NN cord-346964-9afuen7k 210 14 , , , cord-346964-9afuen7k 210 15 including include VBG cord-346964-9afuen7k 210 16 the the DT cord-346964-9afuen7k 210 17 duodenum duodenum NN cord-346964-9afuen7k 210 18 . . . cord-346964-9afuen7k 211 1 Though though IN cord-346964-9afuen7k 211 2 the the DT cord-346964-9afuen7k 211 3 exact exact JJ cord-346964-9afuen7k 211 4 frequency frequency NN cord-346964-9afuen7k 211 5 of of IN cord-346964-9afuen7k 211 6 upper upper JJ cord-346964-9afuen7k 211 7 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 211 8 involvement involvement NN cord-346964-9afuen7k 211 9 in in IN cord-346964-9afuen7k 211 10 Crohn Crohn NNP cord-346964-9afuen7k 211 11 's 's POS cord-346964-9afuen7k 211 12 disease disease NN cord-346964-9afuen7k 211 13 is be VBZ cord-346964-9afuen7k 211 14 not not RB cord-346964-9afuen7k 211 15 known know VBN cord-346964-9afuen7k 211 16 , , , cord-346964-9afuen7k 211 17 it -PRON- PRP cord-346964-9afuen7k 211 18 can can MD cord-346964-9afuen7k 211 19 reach reach VB cord-346964-9afuen7k 211 20 up up IN cord-346964-9afuen7k 211 21 to to TO cord-346964-9afuen7k 211 22 30 30 CD cord-346964-9afuen7k 211 23 - - SYM cord-346964-9afuen7k 211 24 50 50 CD cord-346964-9afuen7k 211 25 % % NN cord-346964-9afuen7k 211 26 of of IN cord-346964-9afuen7k 211 27 cases case NNS cord-346964-9afuen7k 211 28 in in IN cord-346964-9afuen7k 211 29 some some DT cord-346964-9afuen7k 211 30 centers center NNS cord-346964-9afuen7k 211 31 . . . cord-346964-9afuen7k 212 1 Most Most JJS cord-346964-9afuen7k 212 2 patients patient NNS cord-346964-9afuen7k 212 3 with with IN cord-346964-9afuen7k 212 4 involvement involvement NN cord-346964-9afuen7k 212 5 of of IN cord-346964-9afuen7k 212 6 the the DT cord-346964-9afuen7k 212 7 duodenal duodenal JJ cord-346964-9afuen7k 212 8 bulb bulb NN cord-346964-9afuen7k 212 9 have have VBP cord-346964-9afuen7k 212 10 concomitant concomitant JJ cord-346964-9afuen7k 212 11 gastric gastric JJ cord-346964-9afuen7k 212 12 antral antral JJ cord-346964-9afuen7k 212 13 involvement involvement NN cord-346964-9afuen7k 212 14 in in IN cord-346964-9afuen7k 212 15 the the DT cord-346964-9afuen7k 212 16 form form NN cord-346964-9afuen7k 212 17 of of IN cord-346964-9afuen7k 212 18 focal focal JJ cord-346964-9afuen7k 212 19 active active JJ cord-346964-9afuen7k 212 20 inflammation inflammation NN cord-346964-9afuen7k 212 21 . . . cord-346964-9afuen7k 213 1 However however RB cord-346964-9afuen7k 213 2 , , , cord-346964-9afuen7k 213 3 distal distal JJ cord-346964-9afuen7k 213 4 duodenal duodenal JJ cord-346964-9afuen7k 213 5 disease disease NN cord-346964-9afuen7k 213 6 is be VBZ cord-346964-9afuen7k 213 7 usually usually RB cord-346964-9afuen7k 213 8 associated associate VBN cord-346964-9afuen7k 213 9 with with IN cord-346964-9afuen7k 213 10 ileal ileal JJ cord-346964-9afuen7k 213 11 and and CC cord-346964-9afuen7k 213 12 colonic colonic JJ cord-346964-9afuen7k 213 13 involvement involvement NN cord-346964-9afuen7k 213 14 . . . cord-346964-9afuen7k 214 1 Symptoms symptom NNS cord-346964-9afuen7k 214 2 of of IN cord-346964-9afuen7k 214 3 upper upper JJ cord-346964-9afuen7k 214 4 GI GI NNP cord-346964-9afuen7k 214 5 involvement involvement NN cord-346964-9afuen7k 214 6 are be VBP cord-346964-9afuen7k 214 7 epigastric epigastric JJ cord-346964-9afuen7k 214 8 pain pain NN cord-346964-9afuen7k 214 9 , , , cord-346964-9afuen7k 214 10 nausea nausea NN cord-346964-9afuen7k 214 11 and and CC cord-346964-9afuen7k 214 12 vomiting vomiting NN cord-346964-9afuen7k 214 13 , , , cord-346964-9afuen7k 214 14 and and CC cord-346964-9afuen7k 214 15 rarely rarely RB cord-346964-9afuen7k 214 16 diarrhea diarrhea JJ cord-346964-9afuen7k 214 17 . . . cord-346964-9afuen7k 215 1 Endoscopically endoscopically RB cord-346964-9afuen7k 215 2 , , , cord-346964-9afuen7k 215 3 aphthous aphthous JJ cord-346964-9afuen7k 215 4 ulcers ulcer NNS cord-346964-9afuen7k 215 5 and and CC cord-346964-9afuen7k 215 6 granularity granularity NN cord-346964-9afuen7k 215 7 of of IN cord-346964-9afuen7k 215 8 the the DT cord-346964-9afuen7k 215 9 duodenal duodenal JJ cord-346964-9afuen7k 215 10 mucosa mucosa NN cord-346964-9afuen7k 215 11 are be VBP cord-346964-9afuen7k 215 12 seen see VBN cord-346964-9afuen7k 215 13 . . . cord-346964-9afuen7k 216 1 Mild mild JJ cord-346964-9afuen7k 216 2 to to IN cord-346964-9afuen7k 216 3 moderate moderate JJ cord-346964-9afuen7k 216 4 villous villous JJ cord-346964-9afuen7k 216 5 blunting blunting NN cord-346964-9afuen7k 216 6 can can MD cord-346964-9afuen7k 216 7 be be VB cord-346964-9afuen7k 216 8 found find VBN cord-346964-9afuen7k 216 9 in in IN cord-346964-9afuen7k 216 10 the the DT cord-346964-9afuen7k 216 11 duodenum duodenum NN cord-346964-9afuen7k 216 12 together together RB cord-346964-9afuen7k 216 13 with with IN cord-346964-9afuen7k 216 14 patchy patchy JJ cord-346964-9afuen7k 216 15 or or CC cord-346964-9afuen7k 216 16 segmental segmental JJ cord-346964-9afuen7k 216 17 chronic chronic JJ cord-346964-9afuen7k 216 18 inflammation inflammation NN cord-346964-9afuen7k 216 19 in in IN cord-346964-9afuen7k 216 20 the the DT cord-346964-9afuen7k 216 21 lamina lamina JJ cord-346964-9afuen7k 216 22 propria propria NN cord-346964-9afuen7k 216 23 and and CC cord-346964-9afuen7k 216 24 gastric gastric JJ cord-346964-9afuen7k 216 25 mucin mucin NN cord-346964-9afuen7k 216 26 cell cell NN cord-346964-9afuen7k 216 27 metaplasia metaplasia NN cord-346964-9afuen7k 216 28 ( ( -LRB- cord-346964-9afuen7k 216 29 Figure figure NN cord-346964-9afuen7k 216 30 10(a 10(a CD cord-346964-9afuen7k 216 31 ) ) -RRB- cord-346964-9afuen7k 216 32 and and CC cord-346964-9afuen7k 216 33 10(b 10(b LS cord-346964-9afuen7k 216 34 ) ) -RRB- cord-346964-9afuen7k 216 35 ) ) -RRB- cord-346964-9afuen7k 216 36 . . . cord-346964-9afuen7k 217 1 Granulomas granuloma NNS cord-346964-9afuen7k 217 2 are be VBP cord-346964-9afuen7k 217 3 uncommon uncommon JJ cord-346964-9afuen7k 217 4 , , , cord-346964-9afuen7k 217 5 but but CC cord-346964-9afuen7k 217 6 when when WRB cord-346964-9afuen7k 217 7 found find VBN cord-346964-9afuen7k 217 8 , , , cord-346964-9afuen7k 217 9 they -PRON- PRP cord-346964-9afuen7k 217 10 are be VBP cord-346964-9afuen7k 217 11 usually usually RB cord-346964-9afuen7k 217 12 more more RBR cord-346964-9afuen7k 217 13 often often RB cord-346964-9afuen7k 217 14 in in IN cord-346964-9afuen7k 217 15 the the DT cord-346964-9afuen7k 217 16 stomach stomach NN cord-346964-9afuen7k 217 17 than than IN cord-346964-9afuen7k 217 18 the the DT cord-346964-9afuen7k 217 19 duodenum duodenum NN cord-346964-9afuen7k 217 20 and and CC cord-346964-9afuen7k 217 21 can can MD cord-346964-9afuen7k 217 22 be be VB cord-346964-9afuen7k 217 23 helpful helpful JJ cord-346964-9afuen7k 217 24 in in IN cord-346964-9afuen7k 217 25 the the DT cord-346964-9afuen7k 217 26 differential differential JJ cord-346964-9afuen7k 217 27 diagnosis diagnosis NN cord-346964-9afuen7k 217 28 . . . cord-346964-9afuen7k 218 1 There there EX cord-346964-9afuen7k 218 2 is be VBZ cord-346964-9afuen7k 218 3 a a DT cord-346964-9afuen7k 218 4 group group NN cord-346964-9afuen7k 218 5 of of IN cord-346964-9afuen7k 218 6 patients patient NNS cord-346964-9afuen7k 218 7 with with IN cord-346964-9afuen7k 218 8 ulcerative ulcerative JJ cord-346964-9afuen7k 218 9 colitis colitis NN cord-346964-9afuen7k 218 10 that that WDT cord-346964-9afuen7k 218 11 presents present VBZ cord-346964-9afuen7k 218 12 with with IN cord-346964-9afuen7k 218 13 diffuse diffuse JJ cord-346964-9afuen7k 218 14 duodenal duodenal JJ cord-346964-9afuen7k 218 15 involvement involvement NN cord-346964-9afuen7k 218 16 . . . cord-346964-9afuen7k 219 1 This this DT cord-346964-9afuen7k 219 2 has have VBZ cord-346964-9afuen7k 219 3 been be VBN cord-346964-9afuen7k 219 4 reported report VBN cord-346964-9afuen7k 219 5 particularly particularly RB cord-346964-9afuen7k 219 6 in in IN cord-346964-9afuen7k 219 7 patients patient NNS cord-346964-9afuen7k 219 8 with with IN cord-346964-9afuen7k 219 9 pancolitic pancolitic JJ cord-346964-9afuen7k 219 10 presentation presentation NN cord-346964-9afuen7k 219 11 of of IN cord-346964-9afuen7k 219 12 ulcerative ulcerative JJ cord-346964-9afuen7k 219 13 colitis colitis NN cord-346964-9afuen7k 219 14 who who WP cord-346964-9afuen7k 219 15 do do VBP cord-346964-9afuen7k 219 16 not not RB cord-346964-9afuen7k 219 17 respond respond VB cord-346964-9afuen7k 219 18 to to IN cord-346964-9afuen7k 219 19 steroids steroid NNS cord-346964-9afuen7k 219 20 . . . cord-346964-9afuen7k 220 1 Histologically histologically RB cord-346964-9afuen7k 220 2 , , , cord-346964-9afuen7k 220 3 duodenal duodenal JJ cord-346964-9afuen7k 220 4 mucosa mucosa NN cord-346964-9afuen7k 220 5 may may MD cord-346964-9afuen7k 220 6 show show VB cord-346964-9afuen7k 220 7 active active JJ cord-346964-9afuen7k 220 8 duodenitis duodenitis NN cord-346964-9afuen7k 220 9 with with IN cord-346964-9afuen7k 220 10 distortion distortion NN cord-346964-9afuen7k 220 11 of of IN cord-346964-9afuen7k 220 12 the the DT cord-346964-9afuen7k 220 13 crypts crypt NNS cord-346964-9afuen7k 220 14 , , , cord-346964-9afuen7k 220 15 cryptitis cryptitis NNP cord-346964-9afuen7k 220 16 , , , cord-346964-9afuen7k 220 17 and and CC cord-346964-9afuen7k 220 18 even even RB cord-346964-9afuen7k 220 19 crypt crypt JJ cord-346964-9afuen7k 220 20 abscesses abscess NNS cord-346964-9afuen7k 220 21 . . . cord-346964-9afuen7k 221 1 Regardless regardless RB cord-346964-9afuen7k 221 2 of of IN cord-346964-9afuen7k 221 3 the the DT cord-346964-9afuen7k 221 4 type type NN cord-346964-9afuen7k 221 5 of of IN cord-346964-9afuen7k 221 6 IBD IBD NNP cord-346964-9afuen7k 221 7 , , , cord-346964-9afuen7k 221 8 mucosal mucosal JJ cord-346964-9afuen7k 221 9 involvement involvement NN cord-346964-9afuen7k 221 10 of of IN cord-346964-9afuen7k 221 11 the the DT cord-346964-9afuen7k 221 12 small small JJ cord-346964-9afuen7k 221 13 bowel bowel NN cord-346964-9afuen7k 221 14 may may MD cord-346964-9afuen7k 221 15 lead lead VB cord-346964-9afuen7k 221 16 to to IN cord-346964-9afuen7k 221 17 a a DT cord-346964-9afuen7k 221 18 decrease decrease NN cord-346964-9afuen7k 221 19 in in IN cord-346964-9afuen7k 221 20 mucosal mucosal JJ cord-346964-9afuen7k 221 21 surface surface NN cord-346964-9afuen7k 221 22 area area NN cord-346964-9afuen7k 221 23 and and CC cord-346964-9afuen7k 221 24 Table Table NNP cord-346964-9afuen7k 221 25 4 4 CD cord-346964-9afuen7k 221 26 Conditions condition NNS cord-346964-9afuen7k 221 27 that that WDT cord-346964-9afuen7k 221 28 are be VBP cord-346964-9afuen7k 221 29 included include VBN cord-346964-9afuen7k 221 30 in in IN cord-346964-9afuen7k 221 31 the the DT cord-346964-9afuen7k 221 32 differential differential JJ cord-346964-9afuen7k 221 33 diagnosis diagnosis NN cord-346964-9afuen7k 221 34 of of IN cord-346964-9afuen7k 221 35 GSE GSE NNP cord-346964-9afuen7k 222 1 There there EX cord-346964-9afuen7k 222 2 are be VBP cord-346964-9afuen7k 222 3 conditions condition NNS cord-346964-9afuen7k 222 4 causing cause VBG cord-346964-9afuen7k 222 5 malabsorption malabsorption NN cord-346964-9afuen7k 222 6 through through IN cord-346964-9afuen7k 222 7 mechanisms mechanism NNS cord-346964-9afuen7k 222 8 involving involve VBG cord-346964-9afuen7k 222 9 not not RB cord-346964-9afuen7k 222 10 only only RB cord-346964-9afuen7k 222 11 the the DT cord-346964-9afuen7k 222 12 mucosa mucosa NN cord-346964-9afuen7k 222 13 but but CC cord-346964-9afuen7k 222 14 also also RB cord-346964-9afuen7k 222 15 the the DT cord-346964-9afuen7k 222 16 intestinal intestinal JJ cord-346964-9afuen7k 222 17 wall wall NN cord-346964-9afuen7k 222 18 such such JJ cord-346964-9afuen7k 222 19 as as IN cord-346964-9afuen7k 222 20 scleroderma scleroderma NN cord-346964-9afuen7k 222 21 , , , cord-346964-9afuen7k 222 22 amyloidosis amyloidosis NN cord-346964-9afuen7k 222 23 , , , cord-346964-9afuen7k 222 24 eosinophilic eosinophilic JJ cord-346964-9afuen7k 222 25 gastroenteritis gastroenteritis NN cord-346964-9afuen7k 222 26 , , , cord-346964-9afuen7k 222 27 and and CC cord-346964-9afuen7k 222 28 neuromuscular neuromuscular JJ cord-346964-9afuen7k 222 29 disorders disorder NNS cord-346964-9afuen7k 222 30 like like IN cord-346964-9afuen7k 222 31 intestinal intestinal JJ cord-346964-9afuen7k 222 32 familial familial JJ cord-346964-9afuen7k 222 33 neuro neuro NNP cord-346964-9afuen7k 222 34 / / SYM cord-346964-9afuen7k 222 35 myopathies myopathy NNS cord-346964-9afuen7k 222 36 . . . cord-346964-9afuen7k 223 1 The the DT cord-346964-9afuen7k 223 2 pathology pathology NN cord-346964-9afuen7k 223 3 common common JJ cord-346964-9afuen7k 223 4 to to IN cord-346964-9afuen7k 223 5 all all PDT cord-346964-9afuen7k 223 6 the the DT cord-346964-9afuen7k 223 7 aforementioned aforementioned JJ cord-346964-9afuen7k 223 8 conditions condition NNS cord-346964-9afuen7k 223 9 is be VBZ cord-346964-9afuen7k 223 10 the the DT cord-346964-9afuen7k 223 11 resultant resultant JJ cord-346964-9afuen7k 223 12 defective defective JJ cord-346964-9afuen7k 223 13 peristaltism peristaltism NN cord-346964-9afuen7k 223 14 leading lead VBG cord-346964-9afuen7k 223 15 to to IN cord-346964-9afuen7k 223 16 luminal luminal JJ cord-346964-9afuen7k 223 17 stasis stasis NN cord-346964-9afuen7k 223 18 and and CC cord-346964-9afuen7k 223 19 bacterial bacterial JJ cord-346964-9afuen7k 223 20 overgrowth overgrowth NN cord-346964-9afuen7k 223 21 that that WDT cord-346964-9afuen7k 223 22 cause cause VBP cord-346964-9afuen7k 223 23 malabsorption malabsorption NN cord-346964-9afuen7k 223 24 . . . cord-346964-9afuen7k 224 1 GI GI NNP cord-346964-9afuen7k 224 2 involvement involvement NN cord-346964-9afuen7k 224 3 is be VBZ cord-346964-9afuen7k 224 4 very very RB cord-346964-9afuen7k 224 5 common common JJ cord-346964-9afuen7k 224 6 in in IN cord-346964-9afuen7k 224 7 systemic systemic JJ cord-346964-9afuen7k 224 8 amyloidosis amyloidosis NN cord-346964-9afuen7k 224 9 . . . cord-346964-9afuen7k 225 1 GI GI NNP cord-346964-9afuen7k 225 2 symptoms symptom NNS cord-346964-9afuen7k 225 3 comprise comprise VBP cord-346964-9afuen7k 225 4 malabsorption malabsorption NN cord-346964-9afuen7k 225 5 , , , cord-346964-9afuen7k 225 6 hemorrhage hemorrhage NN cord-346964-9afuen7k 225 7 , , , cord-346964-9afuen7k 225 8 nausea nausea NN cord-346964-9afuen7k 225 9 , , , cord-346964-9afuen7k 225 10 and and CC cord-346964-9afuen7k 225 11 vomiting vomit VBG cord-346964-9afuen7k 225 12 . . . cord-346964-9afuen7k 226 1 Endoscopic endoscopic JJ cord-346964-9afuen7k 226 2 findings finding NNS cord-346964-9afuen7k 226 3 are be VBP cord-346964-9afuen7k 226 4 nonspecific nonspecific JJ cord-346964-9afuen7k 226 5 and and CC cord-346964-9afuen7k 226 6 biopsies biopsy NNS cord-346964-9afuen7k 226 7 from from IN cord-346964-9afuen7k 226 8 the the DT cord-346964-9afuen7k 226 9 rectum rectum NN cord-346964-9afuen7k 226 10 and and CC cord-346964-9afuen7k 226 11 stomach stomach NN cord-346964-9afuen7k 226 12 with with IN cord-346964-9afuen7k 226 13 sufficient sufficient JJ cord-346964-9afuen7k 226 14 submucosal submucosal NN cord-346964-9afuen7k 226 15 tissue tissue NN cord-346964-9afuen7k 226 16 aid aid VB cord-346964-9afuen7k 226 17 a a DT cord-346964-9afuen7k 226 18 correct correct JJ cord-346964-9afuen7k 226 19 diagnosis diagnosis NN cord-346964-9afuen7k 226 20 as as IN cord-346964-9afuen7k 226 21 deposition deposition NN cord-346964-9afuen7k 226 22 of of IN cord-346964-9afuen7k 226 23 amyloid amyloid NN cord-346964-9afuen7k 226 24 protein protein NN cord-346964-9afuen7k 226 25 may may MD cord-346964-9afuen7k 226 26 be be VB cord-346964-9afuen7k 226 27 present present JJ cord-346964-9afuen7k 226 28 in in IN cord-346964-9afuen7k 226 29 vessel vessel NN cord-346964-9afuen7k 226 30 walls wall NNS cord-346964-9afuen7k 226 31 , , , cord-346964-9afuen7k 226 32 muscularis muscularis NNP cord-346964-9afuen7k 226 33 mucosae mucosae NNP cord-346964-9afuen7k 226 34 , , , cord-346964-9afuen7k 226 35 and and CC cord-346964-9afuen7k 226 36 nerves nerve NNS cord-346964-9afuen7k 226 37 and and CC cord-346964-9afuen7k 226 38 rarely rarely RB cord-346964-9afuen7k 226 39 as as IN cord-346964-9afuen7k 226 40 extracellular extracellular JJ cord-346964-9afuen7k 226 41 globules globule NNS cord-346964-9afuen7k 226 42 in in IN cord-346964-9afuen7k 226 43 the the DT cord-346964-9afuen7k 226 44 lamina lamina JJ cord-346964-9afuen7k 226 45 propria propria NN cord-346964-9afuen7k 226 46 . . . cord-346964-9afuen7k 227 1 Appropriate appropriate JJ cord-346964-9afuen7k 227 2 histochemical histochemical JJ cord-346964-9afuen7k 227 3 stains stain NNS cord-346964-9afuen7k 227 4 such such JJ cord-346964-9afuen7k 227 5 as as IN cord-346964-9afuen7k 227 6 Congo Congo NNP cord-346964-9afuen7k 227 7 red red NN cord-346964-9afuen7k 227 8 or or CC cord-346964-9afuen7k 227 9 Sirius Sirius NNP cord-346964-9afuen7k 227 10 red red NN cord-346964-9afuen7k 227 11 are be VBP cord-346964-9afuen7k 227 12 necessary necessary JJ cord-346964-9afuen7k 227 13 for for IN cord-346964-9afuen7k 227 14 diagnosis diagnosis NN cord-346964-9afuen7k 227 15 , , , cord-346964-9afuen7k 227 16 while while IN cord-346964-9afuen7k 227 17 immunohistochemistry immunohistochemistry NN cord-346964-9afuen7k 227 18 can can MD cord-346964-9afuen7k 227 19 be be VB cord-346964-9afuen7k 227 20 used use VBN cord-346964-9afuen7k 227 21 to to TO cord-346964-9afuen7k 227 22 classify classify VB cord-346964-9afuen7k 227 23 the the DT cord-346964-9afuen7k 227 24 type type NN cord-346964-9afuen7k 227 25 of of IN cord-346964-9afuen7k 227 26 amyloid amyloid NN cord-346964-9afuen7k 227 27 fibril fibril NNP cord-346964-9afuen7k 227 28 protein protein NN cord-346964-9afuen7k 227 29 . . . cord-346964-9afuen7k 228 1 Deposition deposition NN cord-346964-9afuen7k 228 2 of of IN cord-346964-9afuen7k 228 3 amyloid amyloid NN cord-346964-9afuen7k 228 4 in in IN cord-346964-9afuen7k 228 5 the the DT cord-346964-9afuen7k 228 6 vessels vessel NNS cord-346964-9afuen7k 228 7 causes cause VBZ cord-346964-9afuen7k 228 8 them -PRON- PRP cord-346964-9afuen7k 228 9 to to TO cord-346964-9afuen7k 228 10 become become VB cord-346964-9afuen7k 228 11 leaky leaky JJ cord-346964-9afuen7k 228 12 and and CC cord-346964-9afuen7k 228 13 fragile fragile JJ cord-346964-9afuen7k 228 14 leading lead VBG cord-346964-9afuen7k 228 15 to to IN cord-346964-9afuen7k 228 16 hemorrhage hemorrhage NN cord-346964-9afuen7k 228 17 . . . cord-346964-9afuen7k 229 1 Deposits deposit NNS cord-346964-9afuen7k 229 2 in in IN cord-346964-9afuen7k 229 3 the the DT cord-346964-9afuen7k 229 4 wall wall NN cord-346964-9afuen7k 229 5 , , , cord-346964-9afuen7k 229 6 in in IN cord-346964-9afuen7k 229 7 either either CC cord-346964-9afuen7k 229 8 the the DT cord-346964-9afuen7k 229 9 muscle muscle NN cord-346964-9afuen7k 229 10 or or CC cord-346964-9afuen7k 229 11 nerve nerve NN cord-346964-9afuen7k 229 12 bundles bundle NNS cord-346964-9afuen7k 229 13 , , , cord-346964-9afuen7k 229 14 cause cause VB cord-346964-9afuen7k 229 15 impaired impaired JJ cord-346964-9afuen7k 229 16 motility motility NN cord-346964-9afuen7k 229 17 , , , cord-346964-9afuen7k 229 18 while while IN cord-346964-9afuen7k 229 19 mucosal mucosal JJ cord-346964-9afuen7k 229 20 deposits deposit NNS cord-346964-9afuen7k 229 21 lead lead VBP cord-346964-9afuen7k 229 22 to to IN cord-346964-9afuen7k 229 23 malabsorption malabsorption NN cord-346964-9afuen7k 229 24 and and CC cord-346964-9afuen7k 229 25 diarrhea diarrhea NN cord-346964-9afuen7k 229 26 due due IN cord-346964-9afuen7k 229 27 to to IN cord-346964-9afuen7k 229 28 diminished diminished JJ cord-346964-9afuen7k 229 29 mucosal mucosal JJ cord-346964-9afuen7k 229 30 surface surface NN cord-346964-9afuen7k 229 31 area area NN cord-346964-9afuen7k 229 32 by by IN cord-346964-9afuen7k 229 33 obliteration obliteration NN cord-346964-9afuen7k 229 34 of of IN cord-346964-9afuen7k 229 35 the the DT cord-346964-9afuen7k 229 36 villi villi NN cord-346964-9afuen7k 229 37 . . . cord-346964-9afuen7k 230 1 Is be VBZ cord-346964-9afuen7k 230 2 a a DT cord-346964-9afuen7k 230 3 spectrum spectrum NN cord-346964-9afuen7k 230 4 of of IN cord-346964-9afuen7k 230 5 diseases disease NNS cord-346964-9afuen7k 230 6 characterized characterize VBN cord-346964-9afuen7k 230 7 by by IN cord-346964-9afuen7k 230 8 eosinophilic eosinophilic JJ cord-346964-9afuen7k 230 9 infiltration infiltration NN cord-346964-9afuen7k 230 10 of of IN cord-346964-9afuen7k 230 11 various various JJ cord-346964-9afuen7k 230 12 segments segment NNS cord-346964-9afuen7k 230 13 of of IN cord-346964-9afuen7k 230 14 the the DT cord-346964-9afuen7k 230 15 GI GI NNP cord-346964-9afuen7k 230 16 tract tract NN cord-346964-9afuen7k 230 17 together together RB cord-346964-9afuen7k 230 18 with with IN cord-346964-9afuen7k 230 19 peripheral peripheral JJ cord-346964-9afuen7k 230 20 eosinophilia eosinophilia NN cord-346964-9afuen7k 230 21 and and CC cord-346964-9afuen7k 230 22 coexisting coexist VBG cord-346964-9afuen7k 230 23 allergies allergy NNS cord-346964-9afuen7k 230 24 . . . cord-346964-9afuen7k 231 1 Disorders disorder NNS cord-346964-9afuen7k 231 2 causing cause VBG cord-346964-9afuen7k 231 3 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 231 4 mucosal mucosal NN cord-346964-9afuen7k 231 5 eosinophilia eosinophilia NNS cord-346964-9afuen7k 231 6 are be VBP cord-346964-9afuen7k 231 7 presented present VBN cord-346964-9afuen7k 231 8 in in IN cord-346964-9afuen7k 231 9 Table Table NNP cord-346964-9afuen7k 231 10 5 5 CD cord-346964-9afuen7k 231 11 . . . cord-346964-9afuen7k 232 1 The the DT cord-346964-9afuen7k 232 2 disease disease NN cord-346964-9afuen7k 232 3 may may MD cord-346964-9afuen7k 232 4 be be VB cord-346964-9afuen7k 232 5 patchy patchy JJ cord-346964-9afuen7k 232 6 and and CC cord-346964-9afuen7k 232 7 may may MD cord-346964-9afuen7k 232 8 involve involve VB cord-346964-9afuen7k 232 9 either either CC cord-346964-9afuen7k 232 10 only only RB cord-346964-9afuen7k 232 11 the the DT cord-346964-9afuen7k 232 12 mucosa mucosa JJ cord-346964-9afuen7k 232 13 or or CC cord-346964-9afuen7k 232 14 mural mural NN cord-346964-9afuen7k 232 15 and and CC cord-346964-9afuen7k 232 16 serosal serosal NN cord-346964-9afuen7k 232 17 involvement involvement NN cord-346964-9afuen7k 232 18 may may MD cord-346964-9afuen7k 232 19 also also RB cord-346964-9afuen7k 232 20 be be VB cord-346964-9afuen7k 232 21 found find VBN cord-346964-9afuen7k 232 22 . . . cord-346964-9afuen7k 233 1 The the DT cord-346964-9afuen7k 233 2 mechanism mechanism NN cord-346964-9afuen7k 233 3 is be VBZ cord-346964-9afuen7k 233 4 believed believe VBN cord-346964-9afuen7k 233 5 to to TO cord-346964-9afuen7k 233 6 be be VB cord-346964-9afuen7k 233 7 mediated mediate VBN cord-346964-9afuen7k 233 8 through through IN cord-346964-9afuen7k 233 9 activation activation NN cord-346964-9afuen7k 233 10 of of IN cord-346964-9afuen7k 233 11 Th2 Th2 NNP cord-346964-9afuen7k 233 12 lymphocytes lymphocyte NNS cord-346964-9afuen7k 233 13 leading lead VBG cord-346964-9afuen7k 233 14 to to IN cord-346964-9afuen7k 233 15 an an DT cord-346964-9afuen7k 233 16 increased increase VBN cord-346964-9afuen7k 233 17 production production NN cord-346964-9afuen7k 233 18 of of IN cord-346964-9afuen7k 233 19 proallergenic proallergenic JJ cord-346964-9afuen7k 233 20 interleukins interleukin NNS cord-346964-9afuen7k 233 21 , , , cord-346964-9afuen7k 233 22 especially especially RB cord-346964-9afuen7k 233 23 , , , cord-346964-9afuen7k 233 24 IL-4 IL-4 NNP cord-346964-9afuen7k 233 25 , , , cord-346964-9afuen7k 233 26 IL-5 IL-5 NNP cord-346964-9afuen7k 233 27 , , , cord-346964-9afuen7k 233 28 and and CC cord-346964-9afuen7k 233 29 IL13 IL13 NNP cord-346964-9afuen7k 233 30 . . . cord-346964-9afuen7k 234 1 While while IN cord-346964-9afuen7k 234 2 IL-5 IL-5 NNP cord-346964-9afuen7k 234 3 promotes promote VBZ cord-346964-9afuen7k 234 4 maturation maturation NN cord-346964-9afuen7k 234 5 of of IN cord-346964-9afuen7k 234 6 eosinophils eosinophil NNS cord-346964-9afuen7k 234 7 and and CC cord-346964-9afuen7k 234 8 migration migration NN cord-346964-9afuen7k 234 9 from from IN cord-346964-9afuen7k 234 10 the the DT cord-346964-9afuen7k 234 11 bone bone NN cord-346964-9afuen7k 234 12 marrow marrow NN cord-346964-9afuen7k 234 13 into into IN cord-346964-9afuen7k 234 14 the the DT cord-346964-9afuen7k 234 15 circulating circulate VBG cord-346964-9afuen7k 234 16 bloodstream bloodstream NN cord-346964-9afuen7k 234 17 , , , cord-346964-9afuen7k 234 18 IL-4 IL-4 NNP cord-346964-9afuen7k 234 19 and and CC cord-346964-9afuen7k 234 20 IL-13 IL-13 NNP cord-346964-9afuen7k 234 21 upregulate upregulate VBP cord-346964-9afuen7k 234 22 the the DT cord-346964-9afuen7k 234 23 production production NN cord-346964-9afuen7k 234 24 of of IN cord-346964-9afuen7k 234 25 eotaxin-3 eotaxin-3 NNP cord-346964-9afuen7k 234 26 by by IN cord-346964-9afuen7k 234 27 the the DT cord-346964-9afuen7k 234 28 epithelium epithelium NN cord-346964-9afuen7k 234 29 , , , cord-346964-9afuen7k 234 30 a a DT cord-346964-9afuen7k 234 31 chemokine chemokine NN cord-346964-9afuen7k 234 32 responsible responsible JJ cord-346964-9afuen7k 234 33 for for IN cord-346964-9afuen7k 234 34 attracting attract VBG cord-346964-9afuen7k 234 35 the the DT cord-346964-9afuen7k 234 36 eosinophils eosinophil NNS cord-346964-9afuen7k 234 37 into into IN cord-346964-9afuen7k 234 38 the the DT cord-346964-9afuen7k 234 39 mucosa mucosa NN cord-346964-9afuen7k 234 40 ( ( -LRB- cord-346964-9afuen7k 234 41 Figure figure NN cord-346964-9afuen7k 234 42 11 11 CD cord-346964-9afuen7k 234 43 ) ) -RRB- cord-346964-9afuen7k 234 44 . . . cord-346964-9afuen7k 235 1 As as IN cord-346964-9afuen7k 235 2 a a DT cord-346964-9afuen7k 235 3 result result NN cord-346964-9afuen7k 235 4 , , , cord-346964-9afuen7k 235 5 mature mature JJ cord-346964-9afuen7k 235 6 eosinophils eosinophil NNS cord-346964-9afuen7k 235 7 accumulate accumulate VBP cord-346964-9afuen7k 235 8 in in IN cord-346964-9afuen7k 235 9 the the DT cord-346964-9afuen7k 235 10 intestine intestine NN cord-346964-9afuen7k 235 11 , , , cord-346964-9afuen7k 235 12 are be VBP cord-346964-9afuen7k 235 13 activated activate VBN cord-346964-9afuen7k 235 14 , , , cord-346964-9afuen7k 235 15 and and CC cord-346964-9afuen7k 235 16 degranulate degranulate VB cord-346964-9afuen7k 235 17 releasing release VBG cord-346964-9afuen7k 235 18 multiple multiple JJ cord-346964-9afuen7k 235 19 cytotoxic cytotoxic JJ cord-346964-9afuen7k 235 20 agents agent NNS cord-346964-9afuen7k 235 21 . . . cord-346964-9afuen7k 236 1 Though though IN cord-346964-9afuen7k 236 2 the the DT cord-346964-9afuen7k 236 3 mechanism mechanism NN cord-346964-9afuen7k 236 4 of of IN cord-346964-9afuen7k 236 5 fibrogenesis fibrogenesis NNP cord-346964-9afuen7k 236 6 is be VBZ cord-346964-9afuen7k 236 7 still still RB cord-346964-9afuen7k 236 8 unclear unclear JJ cord-346964-9afuen7k 236 9 , , , cord-346964-9afuen7k 236 10 IL-5 IL-5 NNP cord-346964-9afuen7k 236 11 , , , cord-346964-9afuen7k 236 12 by by IN cord-346964-9afuen7k 236 13 inducing induce VBG cord-346964-9afuen7k 236 14 fibroblast fibroblast NN cord-346964-9afuen7k 236 15 - - HYPH cord-346964-9afuen7k 236 16 myofibroblast myofibroblast NN cord-346964-9afuen7k 236 17 transdifferentiation transdifferentiation NN cord-346964-9afuen7k 236 18 , , , cord-346964-9afuen7k 236 19 may may MD cord-346964-9afuen7k 236 20 be be VB cord-346964-9afuen7k 236 21 the the DT cord-346964-9afuen7k 236 22 critical critical JJ cord-346964-9afuen7k 236 23 molecule molecule NN cord-346964-9afuen7k 236 24 for for IN cord-346964-9afuen7k 236 25 tissue tissue NN cord-346964-9afuen7k 236 26 fibrosis fibrosis NN cord-346964-9afuen7k 236 27 as as RB cord-346964-9afuen7k 236 28 well well RB cord-346964-9afuen7k 236 29 as as IN cord-346964-9afuen7k 236 30 smooth smooth JJ cord-346964-9afuen7k 236 31 muscle muscle NN cord-346964-9afuen7k 236 32 hyperplasia hyperplasia NN cord-346964-9afuen7k 236 33 that that WDT cord-346964-9afuen7k 236 34 leads lead VBZ cord-346964-9afuen7k 236 35 to to IN cord-346964-9afuen7k 236 36 defective defective JJ cord-346964-9afuen7k 236 37 peristaltism peristaltism NN cord-346964-9afuen7k 236 38 and and CC cord-346964-9afuen7k 236 39 malabsorption malabsorption NN cord-346964-9afuen7k 236 40 in in IN cord-346964-9afuen7k 236 41 this this DT cord-346964-9afuen7k 236 42 condition condition NN cord-346964-9afuen7k 236 43 . . . cord-346964-9afuen7k 237 1 Histological Histological NNP cord-346964-9afuen7k 237 2 abnormalities abnormality NNS cord-346964-9afuen7k 237 3 consist consist VBP cord-346964-9afuen7k 237 4 of of IN cord-346964-9afuen7k 237 5 mild mild JJ cord-346964-9afuen7k 237 6 to to IN cord-346964-9afuen7k 237 7 severe severe JJ cord-346964-9afuen7k 237 8 eosinophilic eosinophilic JJ cord-346964-9afuen7k 237 9 infiltrates infiltrate NNS cord-346964-9afuen7k 237 10 in in IN cord-346964-9afuen7k 237 11 the the DT cord-346964-9afuen7k 237 12 lamina lamina JJ cord-346964-9afuen7k 237 13 propria propria NN cord-346964-9afuen7k 237 14 and and CC cord-346964-9afuen7k 237 15 intraepithelial intraepithelial JJ cord-346964-9afuen7k 237 16 eosinophils eosinophil NNS cord-346964-9afuen7k 237 17 both both DT cord-346964-9afuen7k 237 18 in in IN cord-346964-9afuen7k 237 19 the the DT cord-346964-9afuen7k 237 20 surface surface NN cord-346964-9afuen7k 237 21 and and CC cord-346964-9afuen7k 237 22 crypt crypt NN cord-346964-9afuen7k 237 23 epithelium epithelium NN cord-346964-9afuen7k 237 24 , , , cord-346964-9afuen7k 237 25 forming form VBG cord-346964-9afuen7k 237 26 eosinophilic eosinophilic JJ cord-346964-9afuen7k 237 27 crypt crypt JJ cord-346964-9afuen7k 237 28 abscesses abscess NNS cord-346964-9afuen7k 237 29 , , , cord-346964-9afuen7k 237 30 and and CC cord-346964-9afuen7k 237 31 in in IN cord-346964-9afuen7k 237 32 the the DT cord-346964-9afuen7k 237 33 muscularis muscularis NNP cord-346964-9afuen7k 237 34 mucosae mucosae MD cord-346964-9afuen7k 237 35 together together RB cord-346964-9afuen7k 237 36 with with IN cord-346964-9afuen7k 237 37 mildly mildly RB cord-346964-9afuen7k 237 38 increased increase VBN cord-346964-9afuen7k 237 39 IELs iel NNS cord-346964-9afuen7k 237 40 ( ( -LRB- cord-346964-9afuen7k 237 41 Figure figure NN cord-346964-9afuen7k 237 42 12(a 12(a CD cord-346964-9afuen7k 237 43 ) ) -RRB- cord-346964-9afuen7k 237 44 and and CC cord-346964-9afuen7k 237 45 12(b 12(b CD cord-346964-9afuen7k 237 46 ) ) -RRB- cord-346964-9afuen7k 237 47 ) ) -RRB- cord-346964-9afuen7k 237 48 . . . cord-346964-9afuen7k 238 1 Due due IN cord-346964-9afuen7k 238 2 to to IN cord-346964-9afuen7k 238 3 the the DT cord-346964-9afuen7k 238 4 frequent frequent JJ cord-346964-9afuen7k 238 5 use use NN cord-346964-9afuen7k 238 6 of of IN cord-346964-9afuen7k 238 7 NSAIDs nsaid NNS cord-346964-9afuen7k 238 8 , , , cord-346964-9afuen7k 238 9 particularly particularly RB cord-346964-9afuen7k 238 10 in in IN cord-346964-9afuen7k 238 11 the the DT cord-346964-9afuen7k 238 12 elderly elderly JJ cord-346964-9afuen7k 238 13 , , , cord-346964-9afuen7k 238 14 they -PRON- PRP cord-346964-9afuen7k 238 15 are be VBP cord-346964-9afuen7k 238 16 among among IN cord-346964-9afuen7k 238 17 the the DT cord-346964-9afuen7k 238 18 common common JJ cord-346964-9afuen7k 238 19 causes cause NNS cord-346964-9afuen7k 238 20 of of IN cord-346964-9afuen7k 238 21 small small JJ cord-346964-9afuen7k 238 22 intestinal intestinal JJ cord-346964-9afuen7k 238 23 mucosal mucosal JJ cord-346964-9afuen7k 238 24 injury injury NN cord-346964-9afuen7k 238 25 . . . cord-346964-9afuen7k 239 1 NSAIDs nsaids JJ cord-346964-9afuen7k 239 2 cause cause VBP cord-346964-9afuen7k 239 3 nonspecific nonspecific JJ cord-346964-9afuen7k 239 4 erosions erosion NNS cord-346964-9afuen7k 239 5 and and CC cord-346964-9afuen7k 239 6 ulcerations ulceration NNS cord-346964-9afuen7k 239 7 in in IN cord-346964-9afuen7k 239 8 the the DT cord-346964-9afuen7k 239 9 mucosa mucosa NN cord-346964-9afuen7k 239 10 that that WDT cord-346964-9afuen7k 239 11 may may MD cord-346964-9afuen7k 239 12 eventually eventually RB cord-346964-9afuen7k 239 13 lead lead VB cord-346964-9afuen7k 239 14 to to IN cord-346964-9afuen7k 239 15 formation formation NN cord-346964-9afuen7k 239 16 of of IN cord-346964-9afuen7k 239 17 strictures stricture NNS cord-346964-9afuen7k 239 18 in in IN cord-346964-9afuen7k 239 19 as as RB cord-346964-9afuen7k 239 20 high high JJ cord-346964-9afuen7k 239 21 as as IN cord-346964-9afuen7k 239 22 50 50 CD cord-346964-9afuen7k 239 23 - - SYM cord-346964-9afuen7k 239 24 70 70 CD cord-346964-9afuen7k 239 25 % % NN cord-346964-9afuen7k 239 26 in in IN cord-346964-9afuen7k 239 27 patients patient NNS cord-346964-9afuen7k 239 28 using use VBG cord-346964-9afuen7k 239 29 these these DT cord-346964-9afuen7k 239 30 drugs drug NNS cord-346964-9afuen7k 239 31 . . . cord-346964-9afuen7k 240 1 A a DT cord-346964-9afuen7k 240 2 rare rare JJ cord-346964-9afuen7k 240 3 but but CC cord-346964-9afuen7k 240 4 special special JJ cord-346964-9afuen7k 240 5 form form NN cord-346964-9afuen7k 240 6 of of IN cord-346964-9afuen7k 240 7 strictures stricture NNS cord-346964-9afuen7k 240 8 is be VBZ cord-346964-9afuen7k 240 9 known know VBN cord-346964-9afuen7k 240 10 as as IN cord-346964-9afuen7k 240 11 the the DT cord-346964-9afuen7k 240 12 ' ' `` cord-346964-9afuen7k 240 13 diaphragm diaphragm NN cord-346964-9afuen7k 240 14 disease disease NN cord-346964-9afuen7k 240 15 . . . cord-346964-9afuen7k 240 16 ' ' '' cord-346964-9afuen7k 241 1 It -PRON- PRP cord-346964-9afuen7k 241 2 involves involve VBZ cord-346964-9afuen7k 241 3 numerous numerous JJ cord-346964-9afuen7k 241 4 weblike weblike IN cord-346964-9afuen7k 241 5 mucosal mucosal JJ cord-346964-9afuen7k 241 6 septa septa NNP cord-346964-9afuen7k 241 7 projecting project VBG cord-346964-9afuen7k 241 8 into into IN cord-346964-9afuen7k 241 9 the the DT cord-346964-9afuen7k 241 10 lumen lumen NN cord-346964-9afuen7k 241 11 causing cause VBG cord-346964-9afuen7k 241 12 obstruction obstruction NN cord-346964-9afuen7k 241 13 and and CC cord-346964-9afuen7k 241 14 mucosal mucosal JJ cord-346964-9afuen7k 241 15 stasis stasis NN cord-346964-9afuen7k 241 16 . . . cord-346964-9afuen7k 242 1 The the DT cord-346964-9afuen7k 242 2 diaphragms diaphragm NNS cord-346964-9afuen7k 242 3 are be VBP cord-346964-9afuen7k 242 4 commonly commonly RB cord-346964-9afuen7k 242 5 located locate VBN cord-346964-9afuen7k 242 6 in in IN cord-346964-9afuen7k 242 7 the the DT cord-346964-9afuen7k 242 8 terminal terminal JJ cord-346964-9afuen7k 242 9 ileum ileum NN cord-346964-9afuen7k 242 10 , , , cord-346964-9afuen7k 242 11 leading lead VBG cord-346964-9afuen7k 242 12 to to IN cord-346964-9afuen7k 242 13 protein protein NN cord-346964-9afuen7k 242 14 - - HYPH cord-346964-9afuen7k 242 15 losing lose VBG cord-346964-9afuen7k 242 16 enteropathy enteropathy NNP cord-346964-9afuen7k 242 17 . . . cord-346964-9afuen7k 243 1 Histology histology NN cord-346964-9afuen7k 243 2 of of IN cord-346964-9afuen7k 243 3 these these DT cord-346964-9afuen7k 243 4 diaphragms diaphragm NNS cord-346964-9afuen7k 243 5 comprises comprise VBZ cord-346964-9afuen7k 243 6 reactive reactive JJ cord-346964-9afuen7k 243 7 epithelium epithelium NN cord-346964-9afuen7k 243 8 and and CC cord-346964-9afuen7k 243 9 prominent prominent JJ cord-346964-9afuen7k 243 10 submucosal submucosal NNP cord-346964-9afuen7k 243 11 fibrosis fibrosis NN cord-346964-9afuen7k 243 12 lying lie VBG cord-346964-9afuen7k 243 13 perpendicular perpendicular JJ cord-346964-9afuen7k 243 14 to to IN cord-346964-9afuen7k 243 15 the the DT cord-346964-9afuen7k 243 16 surface surface NN cord-346964-9afuen7k 243 17 . . . cord-346964-9afuen7k 243 18 _SP cord-346964-9afuen7k 244 1 This this DT cord-346964-9afuen7k 244 2 is be VBZ cord-346964-9afuen7k 244 3 the the DT cord-346964-9afuen7k 244 4 most most RBS cord-346964-9afuen7k 244 5 common common JJ cord-346964-9afuen7k 244 6 enteropathy enteropathy NNS cord-346964-9afuen7k 244 7 of of IN cord-346964-9afuen7k 244 8 childhood childhood NN cord-346964-9afuen7k 244 9 . . . cord-346964-9afuen7k 245 1 It -PRON- PRP cord-346964-9afuen7k 245 2 is be VBZ cord-346964-9afuen7k 245 3 a a DT cord-346964-9afuen7k 245 4 rare rare JJ cord-346964-9afuen7k 245 5 condition condition NN cord-346964-9afuen7k 245 6 caused cause VBN cord-346964-9afuen7k 245 7 by by IN cord-346964-9afuen7k 245 8 autoantibodies autoantibody NNS cord-346964-9afuen7k 245 9 to to TO cord-346964-9afuen7k 245 10 intestinal intestinal JJ cord-346964-9afuen7k 245 11 mucosa mucosa JJ cord-346964-9afuen7k 245 12 primarily primarily RB cord-346964-9afuen7k 245 13 affecting affect VBG cord-346964-9afuen7k 245 14 children child NNS cord-346964-9afuen7k 245 15 who who WP cord-346964-9afuen7k 245 16 suffer suffer VBP cord-346964-9afuen7k 245 17 from from IN cord-346964-9afuen7k 245 18 severe severe JJ cord-346964-9afuen7k 245 19 chronic chronic JJ cord-346964-9afuen7k 245 20 diarrhea diarrhea NN cord-346964-9afuen7k 245 21 within within IN cord-346964-9afuen7k 245 22 the the DT cord-346964-9afuen7k 245 23 first first JJ cord-346964-9afuen7k 245 24 months month NNS cord-346964-9afuen7k 245 25 of of IN cord-346964-9afuen7k 245 26 life life NN cord-346964-9afuen7k 245 27 . . . cord-346964-9afuen7k 246 1 The the DT cord-346964-9afuen7k 246 2 patients patient NNS cord-346964-9afuen7k 246 3 may may MD cord-346964-9afuen7k 246 4 have have VB cord-346964-9afuen7k 246 5 a a DT cord-346964-9afuen7k 246 6 variety variety NN cord-346964-9afuen7k 246 7 of of IN cord-346964-9afuen7k 246 8 autoantibodies autoantibody NNS cord-346964-9afuen7k 246 9 to to IN cord-346964-9afuen7k 246 10 self self NN cord-346964-9afuen7k 246 11 - - HYPH cord-346964-9afuen7k 246 12 antigens antigen NNS cord-346964-9afuen7k 246 13 in in IN cord-346964-9afuen7k 246 14 different different JJ cord-346964-9afuen7k 246 15 organs organ NNS cord-346964-9afuen7k 246 16 including include VBG cord-346964-9afuen7k 246 17 the the DT cord-346964-9afuen7k 246 18 pancreas pancreas NN cord-346964-9afuen7k 246 19 , , , cord-346964-9afuen7k 246 20 thyroid thyroid NN cord-346964-9afuen7k 246 21 , , , cord-346964-9afuen7k 246 22 and and CC cord-346964-9afuen7k 246 23 small small JJ cord-346964-9afuen7k 246 24 intestine intestine NN cord-346964-9afuen7k 246 25 and and CC cord-346964-9afuen7k 246 26 may may MD cord-346964-9afuen7k 246 27 suffer suffer VB cord-346964-9afuen7k 246 28 from from IN cord-346964-9afuen7k 246 29 other other JJ cord-346964-9afuen7k 246 30 autoimmune autoimmune JJ cord-346964-9afuen7k 246 31 disorders disorder NNS cord-346964-9afuen7k 246 32 such such JJ cord-346964-9afuen7k 246 33 as as IN cord-346964-9afuen7k 246 34 rheumatoid rheumatoid JJ cord-346964-9afuen7k 246 35 arthritis arthritis NN cord-346964-9afuen7k 246 36 , , , cord-346964-9afuen7k 246 37 myasthenia myasthenia NN cord-346964-9afuen7k 246 38 gravis gravis NN cord-346964-9afuen7k 246 39 , , , cord-346964-9afuen7k 246 40 psoriatic psoriatic JJ cord-346964-9afuen7k 246 41 arthritis arthritis NN cord-346964-9afuen7k 246 42 , , , cord-346964-9afuen7k 246 43 hypoparathyroidism hypoparathyroidism NN cord-346964-9afuen7k 246 44 , , , cord-346964-9afuen7k 246 45 idiopathic idiopathic JJ cord-346964-9afuen7k 246 46 thrombocytopenic thrombocytopenic JJ cord-346964-9afuen7k 246 47 purpura purpura NN cord-346964-9afuen7k 246 48 , , , cord-346964-9afuen7k 246 49 and and CC cord-346964-9afuen7k 246 50 atrophic atrophic JJ cord-346964-9afuen7k 246 51 gastritis gastritis NN cord-346964-9afuen7k 246 52 . . . cord-346964-9afuen7k 247 1 The the DT cord-346964-9afuen7k 247 2 hallmark hallmark NN cord-346964-9afuen7k 247 3 of of IN cord-346964-9afuen7k 247 4 the the DT cord-346964-9afuen7k 247 5 disease disease NN cord-346964-9afuen7k 247 6 is be VBZ cord-346964-9afuen7k 247 7 the the DT cord-346964-9afuen7k 247 8 presence presence NN cord-346964-9afuen7k 247 9 of of IN cord-346964-9afuen7k 247 10 autoantibodies autoantibody NNS cord-346964-9afuen7k 247 11 to to IN cord-346964-9afuen7k 247 12 goblet goblet NN cord-346964-9afuen7k 247 13 cells cell NNS cord-346964-9afuen7k 247 14 , , , cord-346964-9afuen7k 247 15 enterocytes enterocyte NNS cord-346964-9afuen7k 247 16 , , , cord-346964-9afuen7k 247 17 parietal parietal JJ cord-346964-9afuen7k 247 18 cells cell NNS cord-346964-9afuen7k 247 19 , , , cord-346964-9afuen7k 247 20 or or CC cord-346964-9afuen7k 247 21 islet islet NN cord-346964-9afuen7k 247 22 cells cell NNS cord-346964-9afuen7k 247 23 . . . cord-346964-9afuen7k 248 1 There there EX cord-346964-9afuen7k 248 2 are be VBP cord-346964-9afuen7k 248 3 two two CD cord-346964-9afuen7k 248 4 variants variant NNS cord-346964-9afuen7k 248 5 of of IN cord-346964-9afuen7k 248 6 the the DT cord-346964-9afuen7k 248 7 disease disease NN cord-346964-9afuen7k 248 8 , , , cord-346964-9afuen7k 248 9 namely namely RB cord-346964-9afuen7k 248 10 , , , cord-346964-9afuen7k 248 11 IPEX IPEX NNP cord-346964-9afuen7k 248 12 ( ( -LRB- cord-346964-9afuen7k 248 13 immune immune JJ cord-346964-9afuen7k 248 14 dysregulation dysregulation NN cord-346964-9afuen7k 248 15 , , , cord-346964-9afuen7k 248 16 polyendocrinopathy polyendocrinopathy NNP cord-346964-9afuen7k 248 17 , , , cord-346964-9afuen7k 248 18 enteropathy enteropathy NNP cord-346964-9afuen7k 248 19 , , , cord-346964-9afuen7k 248 20 X x NN cord-346964-9afuen7k 248 21 - - HYPH cord-346964-9afuen7k 248 22 linked link VBN cord-346964-9afuen7k 248 23 ) ) -RRB- cord-346964-9afuen7k 248 24 and and CC cord-346964-9afuen7k 248 25 APECED APECED NNP cord-346964-9afuen7k 248 26 ( ( -LRB- cord-346964-9afuen7k 248 27 autoimmune autoimmune JJ cord-346964-9afuen7k 248 28 polyendocrinopathy polyendocrinopathy NN cord-346964-9afuen7k 248 29 , , , cord-346964-9afuen7k 248 30 candidiasis candidiasis NN cord-346964-9afuen7k 248 31 , , , cord-346964-9afuen7k 248 32 ectodermal ectodermal NN cord-346964-9afuen7k 248 33 dystrophy dystrophy NN cord-346964-9afuen7k 248 34 ) ) -RRB- cord-346964-9afuen7k 248 35 syndromes syndrome NNS cord-346964-9afuen7k 248 36 . . . cord-346964-9afuen7k 249 1 IPEX IPEX NNP cord-346964-9afuen7k 249 2 is be VBZ cord-346964-9afuen7k 249 3 an an DT cord-346964-9afuen7k 249 4 X x NN cord-346964-9afuen7k 249 5 - - HYPH cord-346964-9afuen7k 249 6 linked link VBN cord-346964-9afuen7k 249 7 fatal fatal JJ cord-346964-9afuen7k 249 8 condition condition NN cord-346964-9afuen7k 249 9 causing cause VBG cord-346964-9afuen7k 249 10 prolonged prolonged JJ cord-346964-9afuen7k 249 11 diarrhea diarrhea NN cord-346964-9afuen7k 249 12 . . . cord-346964-9afuen7k 250 1 APECED APECED NNP cord-346964-9afuen7k 250 2 or or CC cord-346964-9afuen7k 250 3 autoimmune autoimmune JJ cord-346964-9afuen7k 250 4 polyglandular polyglandular NNP cord-346964-9afuen7k 250 5 syndrome syndrome NN cord-346964-9afuen7k 250 6 1 1 CD cord-346964-9afuen7k 251 1 ( ( -LRB- cord-346964-9afuen7k 251 2 APS-1 APS-1 NNP cord-346964-9afuen7k 251 3 ) ) -RRB- cord-346964-9afuen7k 251 4 is be VBZ cord-346964-9afuen7k 251 5 an an DT cord-346964-9afuen7k 251 6 autosomal autosomal JJ cord-346964-9afuen7k 251 7 recessive recessive JJ cord-346964-9afuen7k 251 8 disease disease NN cord-346964-9afuen7k 251 9 characterized characterize VBN cord-346964-9afuen7k 251 10 by by IN cord-346964-9afuen7k 251 11 severe severe JJ cord-346964-9afuen7k 251 12 enteropathy enteropathy NNS cord-346964-9afuen7k 251 13 . . . cord-346964-9afuen7k 252 1 Histological Histological NNP cord-346964-9afuen7k 252 2 findings finding NNS cord-346964-9afuen7k 252 3 of of IN cord-346964-9afuen7k 252 4 villous villous NN cord-346964-9afuen7k 252 5 flattening flattening NN cord-346964-9afuen7k 252 6 and and CC cord-346964-9afuen7k 252 7 crypt crypt JJ cord-346964-9afuen7k 252 8 hyperplasia hyperplasia NN cord-346964-9afuen7k 252 9 are be VBP cord-346964-9afuen7k 252 10 similar similar JJ cord-346964-9afuen7k 252 11 to to IN cord-346964-9afuen7k 252 12 GSE GSE NNP cord-346964-9afuen7k 252 13 , , , cord-346964-9afuen7k 252 14 but but CC cord-346964-9afuen7k 252 15 the the DT cord-346964-9afuen7k 252 16 resultant resultant JJ cord-346964-9afuen7k 252 17 secretory secretory JJ cord-346964-9afuen7k 252 18 diarrhea diarrhea NN cord-346964-9afuen7k 252 19 is be VBZ cord-346964-9afuen7k 252 20 unresponsive unresponsive JJ cord-346964-9afuen7k 252 21 to to IN cord-346964-9afuen7k 252 22 GFD GFD NNP cord-346964-9afuen7k 252 23 or or CC cord-346964-9afuen7k 252 24 total total JJ cord-346964-9afuen7k 252 25 parenteral parenteral JJ cord-346964-9afuen7k 252 26 nutrition nutrition NN cord-346964-9afuen7k 252 27 ( ( -LRB- cord-346964-9afuen7k 252 28 TPN TPN NNP cord-346964-9afuen7k 252 29 ) ) -RRB- cord-346964-9afuen7k 252 30 . . . cord-346964-9afuen7k 253 1 There there EX cord-346964-9afuen7k 253 2 are be VBP cord-346964-9afuen7k 253 3 lymphoplasmacytic lymphoplasmacytic JJ cord-346964-9afuen7k 253 4 infiltration infiltration NN cord-346964-9afuen7k 253 5 in in IN cord-346964-9afuen7k 253 6 the the DT cord-346964-9afuen7k 253 7 lamina lamina JJ cord-346964-9afuen7k 253 8 propria propria NN cord-346964-9afuen7k 253 9 and and CC cord-346964-9afuen7k 253 10 IELosis IELosis NNP cord-346964-9afuen7k 253 11 , , , cord-346964-9afuen7k 253 12 though though IN cord-346964-9afuen7k 253 13 not not RB cord-346964-9afuen7k 253 14 as as RB cord-346964-9afuen7k 253 15 intense intense JJ cord-346964-9afuen7k 253 16 as as IN cord-346964-9afuen7k 253 17 in in IN cord-346964-9afuen7k 253 18 CD CD NNP cord-346964-9afuen7k 253 19 , , , cord-346964-9afuen7k 253 20 and and CC cord-346964-9afuen7k 253 21 they -PRON- PRP cord-346964-9afuen7k 253 22 are be VBP cord-346964-9afuen7k 253 23 mainly mainly RB cord-346964-9afuen7k 253 24 Bone Bone NNP cord-346964-9afuen7k 253 25 marrow marrow NN cord-346964-9afuen7k 253 26 Figure figure NN cord-346964-9afuen7k 253 27 11 11 CD cord-346964-9afuen7k 253 28 Mechanism Mechanism NNP cord-346964-9afuen7k 253 29 of of IN cord-346964-9afuen7k 253 30 eosinophilic eosinophilic JJ cord-346964-9afuen7k 253 31 enteritis enteritis NN cord-346964-9afuen7k 253 32 is be VBZ cord-346964-9afuen7k 253 33 mediated mediate VBN cord-346964-9afuen7k 253 34 through through IN cord-346964-9afuen7k 253 35 activation activation NN cord-346964-9afuen7k 253 36 of of IN cord-346964-9afuen7k 253 37 Th2 Th2 NNP cord-346964-9afuen7k 253 38 lymphocytes lymphocyte NNS cord-346964-9afuen7k 253 39 leading lead VBG cord-346964-9afuen7k 253 40 to to IN cord-346964-9afuen7k 253 41 an an DT cord-346964-9afuen7k 253 42 increased increase VBN cord-346964-9afuen7k 253 43 production production NN cord-346964-9afuen7k 253 44 of of IN cord-346964-9afuen7k 253 45 proallergenic proallergenic JJ cord-346964-9afuen7k 253 46 interleukins interleukin NNS cord-346964-9afuen7k 253 47 , , , cord-346964-9afuen7k 253 48 especially especially RB cord-346964-9afuen7k 253 49 , , , cord-346964-9afuen7k 253 50 IL-4 IL-4 NNP cord-346964-9afuen7k 253 51 , , , cord-346964-9afuen7k 253 52 IL-5 IL-5 NNP cord-346964-9afuen7k 253 53 , , , cord-346964-9afuen7k 254 1 and and CC cord-346964-9afuen7k 254 2 IL13 IL13 NNP cord-346964-9afuen7k 254 3 . . . cord-346964-9afuen7k 255 1 While while IN cord-346964-9afuen7k 255 2 IL-5 IL-5 NNP cord-346964-9afuen7k 255 3 promotes promote VBZ cord-346964-9afuen7k 255 4 maturation maturation NN cord-346964-9afuen7k 255 5 of of IN cord-346964-9afuen7k 255 6 eosinophils eosinophil NNS cord-346964-9afuen7k 255 7 and and CC cord-346964-9afuen7k 255 8 migration migration NN cord-346964-9afuen7k 255 9 from from IN cord-346964-9afuen7k 255 10 the the DT cord-346964-9afuen7k 255 11 bone bone NN cord-346964-9afuen7k 255 12 marrow marrow NN cord-346964-9afuen7k 255 13 into into IN cord-346964-9afuen7k 255 14 the the DT cord-346964-9afuen7k 255 15 circulating circulate VBG cord-346964-9afuen7k 255 16 blood blood NN cord-346964-9afuen7k 255 17 stream stream NN cord-346964-9afuen7k 255 18 , , , cord-346964-9afuen7k 255 19 IL-4 IL-4 NNP cord-346964-9afuen7k 255 20 and and CC cord-346964-9afuen7k 255 21 IL-13 IL-13 NNP cord-346964-9afuen7k 255 22 upregulate upregulate VBP cord-346964-9afuen7k 255 23 the the DT cord-346964-9afuen7k 255 24 production production NN cord-346964-9afuen7k 255 25 of of IN cord-346964-9afuen7k 255 26 eotaxin-3 eotaxin-3 NNP cord-346964-9afuen7k 255 27 by by IN cord-346964-9afuen7k 255 28 the the DT cord-346964-9afuen7k 255 29 epithelium epithelium NN cord-346964-9afuen7k 255 30 , , , cord-346964-9afuen7k 255 31 a a DT cord-346964-9afuen7k 255 32 chemokine chemokine NN cord-346964-9afuen7k 255 33 responsible responsible JJ cord-346964-9afuen7k 255 34 for for IN cord-346964-9afuen7k 255 35 attracting attract VBG cord-346964-9afuen7k 255 36 the the DT cord-346964-9afuen7k 255 37 eosinophils eosinophil NNS cord-346964-9afuen7k 255 38 into into IN cord-346964-9afuen7k 255 39 the the DT cord-346964-9afuen7k 255 40 mucosa mucosa NN cord-346964-9afuen7k 255 41 . . . cord-346964-9afuen7k 256 1 located locate VBN cord-346964-9afuen7k 256 2 in in IN cord-346964-9afuen7k 256 3 the the DT cord-346964-9afuen7k 256 4 deeper deep JJR cord-346964-9afuen7k 256 5 crypts crypt NNS cord-346964-9afuen7k 256 6 together together RB cord-346964-9afuen7k 256 7 with with IN cord-346964-9afuen7k 256 8 crypt crypt JJ cord-346964-9afuen7k 256 9 epithelial epithelial JJ cord-346964-9afuen7k 256 10 cell cell NN cord-346964-9afuen7k 256 11 apoptosis apoptosis NN cord-346964-9afuen7k 256 12 . . . cord-346964-9afuen7k 257 1 There there EX cord-346964-9afuen7k 257 2 may may MD cord-346964-9afuen7k 257 3 be be VB cord-346964-9afuen7k 257 4 absence absence NN cord-346964-9afuen7k 257 5 of of IN cord-346964-9afuen7k 257 6 goblet goblet NN cord-346964-9afuen7k 257 7 cells cell NNS cord-346964-9afuen7k 257 8 , , , cord-346964-9afuen7k 257 9 Paneth Paneth NNP cord-346964-9afuen7k 257 10 cells cell NNS cord-346964-9afuen7k 257 11 , , , cord-346964-9afuen7k 257 12 or or CC cord-346964-9afuen7k 257 13 endocrine endocrine JJ cord-346964-9afuen7k 257 14 cells cell NNS cord-346964-9afuen7k 257 15 depending depend VBG cord-346964-9afuen7k 257 16 on on IN cord-346964-9afuen7k 257 17 the the DT cord-346964-9afuen7k 257 18 autoantibodies autoantibody NNS cord-346964-9afuen7k 257 19 . . . cord-346964-9afuen7k 258 1 Primary primary JJ cord-346964-9afuen7k 258 2 enteropathies enteropathy NNS cord-346964-9afuen7k 258 3 of of IN cord-346964-9afuen7k 258 4 infancy infancy NN cord-346964-9afuen7k 258 5 are be VBP cord-346964-9afuen7k 258 6 composed compose VBN cord-346964-9afuen7k 258 7 of of IN cord-346964-9afuen7k 258 8 epithelial epithelial JJ cord-346964-9afuen7k 258 9 defects defect NNS cord-346964-9afuen7k 258 10 including include VBG cord-346964-9afuen7k 258 11 microvillus microvillus NNP cord-346964-9afuen7k 258 12 inclusion inclusion NN cord-346964-9afuen7k 258 13 disease disease NN cord-346964-9afuen7k 258 14 ( ( -LRB- cord-346964-9afuen7k 258 15 MVID MVID NNP cord-346964-9afuen7k 258 16 ) ) -RRB- cord-346964-9afuen7k 258 17 , , , cord-346964-9afuen7k 258 18 tufting tufte VBG cord-346964-9afuen7k 258 19 enteropathy enteropathy NNP cord-346964-9afuen7k 258 20 ( ( -LRB- cord-346964-9afuen7k 258 21 TE TE NNP cord-346964-9afuen7k 258 22 ) ) -RRB- cord-346964-9afuen7k 258 23 , , , cord-346964-9afuen7k 258 24 and and CC cord-346964-9afuen7k 258 25 enteroendocrine enteroendocrine JJ cord-346964-9afuen7k 258 26 cell cell NN cord-346964-9afuen7k 258 27 dysgenesis dysgenesis NN cord-346964-9afuen7k 258 28 . . . cord-346964-9afuen7k 259 1 MVID MVID NNP cord-346964-9afuen7k 259 2 ( ( -LRB- cord-346964-9afuen7k 259 3 ' ' `` cord-346964-9afuen7k 259 4 microvillus microvillus NNP cord-346964-9afuen7k 259 5 atrophy atrophy NNP cord-346964-9afuen7k 259 6 ' ' '' cord-346964-9afuen7k 259 7 ) ) -RRB- cord-346964-9afuen7k 259 8 is be VBZ cord-346964-9afuen7k 259 9 an an DT cord-346964-9afuen7k 259 10 uncommon uncommon JJ cord-346964-9afuen7k 259 11 congenital congenital JJ cord-346964-9afuen7k 259 12 enteropathy enteropathy NNS cord-346964-9afuen7k 259 13 characterized characterize VBN cord-346964-9afuen7k 259 14 by by IN cord-346964-9afuen7k 259 15 severe severe JJ cord-346964-9afuen7k 259 16 , , , cord-346964-9afuen7k 259 17 intractable intractable JJ cord-346964-9afuen7k 259 18 diarrhea diarrhea NN cord-346964-9afuen7k 259 19 within within IN cord-346964-9afuen7k 259 20 the the DT cord-346964-9afuen7k 259 21 first first JJ cord-346964-9afuen7k 259 22 week week NN cord-346964-9afuen7k 259 23 of of IN cord-346964-9afuen7k 259 24 life life NN cord-346964-9afuen7k 259 25 . . . cord-346964-9afuen7k 260 1 The the DT cord-346964-9afuen7k 260 2 disease disease NN cord-346964-9afuen7k 260 3 was be VBD cord-346964-9afuen7k 260 4 first first RB cord-346964-9afuen7k 260 5 described describe VBN cord-346964-9afuen7k 260 6 by by IN cord-346964-9afuen7k 260 7 Davidson Davidson NNP cord-346964-9afuen7k 260 8 et et NNP cord-346964-9afuen7k 260 9 al al NNP cord-346964-9afuen7k 260 10 . . . cord-346964-9afuen7k 261 1 in in IN cord-346964-9afuen7k 261 2 1978 1978 CD cord-346964-9afuen7k 261 3 as as IN cord-346964-9afuen7k 261 4 severe severe JJ cord-346964-9afuen7k 261 5 secretory secretory JJ cord-346964-9afuen7k 261 6 diarrhea diarrhea NN cord-346964-9afuen7k 261 7 occurring occur VBG cord-346964-9afuen7k 261 8 during during IN cord-346964-9afuen7k 261 9 the the DT cord-346964-9afuen7k 261 10 first first JJ cord-346964-9afuen7k 261 11 week week NN cord-346964-9afuen7k 261 12 of of IN cord-346964-9afuen7k 261 13 life life NN cord-346964-9afuen7k 261 14 with with IN cord-346964-9afuen7k 261 15 villous villous JJ cord-346964-9afuen7k 261 16 atrophy atrophy NN cord-346964-9afuen7k 261 17 in in IN cord-346964-9afuen7k 261 18 the the DT cord-346964-9afuen7k 261 19 intestinal intestinal JJ cord-346964-9afuen7k 261 20 biopsy biopsy NN cord-346964-9afuen7k 261 21 . . . cord-346964-9afuen7k 262 1 It -PRON- PRP cord-346964-9afuen7k 262 2 has have VBZ cord-346964-9afuen7k 262 3 been be VBN cord-346964-9afuen7k 262 4 demonstrated demonstrate VBN cord-346964-9afuen7k 262 5 that that IN cord-346964-9afuen7k 262 6 MYO5B myo5b CD cord-346964-9afuen7k 262 7 gene gene NN cord-346964-9afuen7k 262 8 located locate VBN cord-346964-9afuen7k 262 9 on on IN cord-346964-9afuen7k 262 10 18q21 18q21 CD cord-346964-9afuen7k 262 11 encoding encoding NN cord-346964-9afuen7k 262 12 myosin myosin NN cord-346964-9afuen7k 262 13 Vb Vb NNP cord-346964-9afuen7k 262 14 that that WDT cord-346964-9afuen7k 262 15 regulates regulate VBZ cord-346964-9afuen7k 262 16 the the DT cord-346964-9afuen7k 262 17 organization organization NN cord-346964-9afuen7k 262 18 of of IN cord-346964-9afuen7k 262 19 intracellular intracellular JJ cord-346964-9afuen7k 262 20 transport transport NN cord-346964-9afuen7k 262 21 and and CC cord-346964-9afuen7k 262 22 cell cell NN cord-346964-9afuen7k 262 23 surface surface NN cord-346964-9afuen7k 262 24 polarity polarity NN cord-346964-9afuen7k 262 25 in in IN cord-346964-9afuen7k 262 26 epithelial epithelial JJ cord-346964-9afuen7k 262 27 cells cell NNS cord-346964-9afuen7k 262 28 . . . cord-346964-9afuen7k 263 1 Myosin Myosin NNP cord-346964-9afuen7k 263 2 Vb Vb NNP cord-346964-9afuen7k 263 3 - - HYPH cord-346964-9afuen7k 263 4 deficient deficient JJ cord-346964-9afuen7k 263 5 enterocytes enterocyte NNS cord-346964-9afuen7k 263 6 display display NN cord-346964-9afuen7k 263 7 disruption disruption NN cord-346964-9afuen7k 263 8 of of IN cord-346964-9afuen7k 263 9 cell cell NN cord-346964-9afuen7k 263 10 polarity polarity NN cord-346964-9afuen7k 263 11 as as IN cord-346964-9afuen7k 263 12 reflected reflect VBN cord-346964-9afuen7k 263 13 by by IN cord-346964-9afuen7k 263 14 mislocalized mislocalized NNP cord-346964-9afuen7k 263 15 apical apical JJ cord-346964-9afuen7k 263 16 and and CC cord-346964-9afuen7k 263 17 basolateral basolateral JJ cord-346964-9afuen7k 263 18 transporter transporter NN cord-346964-9afuen7k 263 19 proteins protein NNS cord-346964-9afuen7k 263 20 including include VBG cord-346964-9afuen7k 263 21 CD36 CD36 NNP cord-346964-9afuen7k 263 22 , , , cord-346964-9afuen7k 263 23 altered altered JJ cord-346964-9afuen7k 263 24 distribution distribution NN cord-346964-9afuen7k 263 25 of of IN cord-346964-9afuen7k 263 26 certain certain JJ cord-346964-9afuen7k 263 27 endosomal endosomal NNP cord-346964-9afuen7k 263 28 / / SYM cord-346964-9afuen7k 263 29 lysosomal lysosomal JJ cord-346964-9afuen7k 263 30 constituents constituent NNS cord-346964-9afuen7k 263 31 including include VBG cord-346964-9afuen7k 263 32 Rab Rab NNP cord-346964-9afuen7k 263 33 GTPases gtpase NNS cord-346964-9afuen7k 263 34 , , , cord-346964-9afuen7k 263 35 and and CC cord-346964-9afuen7k 263 36 disorganization disorganization NN cord-346964-9afuen7k 263 37 in in IN cord-346964-9afuen7k 263 38 the the DT cord-346964-9afuen7k 263 39 distribution distribution NN cord-346964-9afuen7k 263 40 of of IN cord-346964-9afuen7k 263 41 actin actin NN cord-346964-9afuen7k 263 42 myofilaments myofilament NNS cord-346964-9afuen7k 263 43 ( ( -LRB- cord-346964-9afuen7k 263 44 Figure figure NN cord-346964-9afuen7k 263 45 13 13 CD cord-346964-9afuen7k 263 46 ) ) -RRB- cord-346964-9afuen7k 263 47 . . . cord-346964-9afuen7k 264 1 Although although IN cord-346964-9afuen7k 264 2 described describe VBN cord-346964-9afuen7k 264 3 as as IN cord-346964-9afuen7k 264 4 a a DT cord-346964-9afuen7k 264 5 disease disease NN cord-346964-9afuen7k 264 6 of of IN cord-346964-9afuen7k 264 7 the the DT cord-346964-9afuen7k 264 8 small small JJ cord-346964-9afuen7k 264 9 intestine intestine NN cord-346964-9afuen7k 264 10 , , , cord-346964-9afuen7k 264 11 there there EX cord-346964-9afuen7k 264 12 are be VBP cord-346964-9afuen7k 264 13 few few JJ cord-346964-9afuen7k 264 14 reports report NNS cord-346964-9afuen7k 264 15 of of IN cord-346964-9afuen7k 264 16 colonic colonic JJ cord-346964-9afuen7k 264 17 involvement involvement NN cord-346964-9afuen7k 264 18 . . . cord-346964-9afuen7k 265 1 Successful successful JJ cord-346964-9afuen7k 265 2 outcomes outcome NNS cord-346964-9afuen7k 265 3 of of IN cord-346964-9afuen7k 265 4 small small JJ cord-346964-9afuen7k 265 5 intestinal intestinal JJ cord-346964-9afuen7k 265 6 transplantation transplantation NN cord-346964-9afuen7k 265 7 have have VBP cord-346964-9afuen7k 265 8 been be VBN cord-346964-9afuen7k 265 9 reported report VBN cord-346964-9afuen7k 265 10 , , , cord-346964-9afuen7k 265 11 and and CC cord-346964-9afuen7k 265 12 evidence evidence NN cord-346964-9afuen7k 265 13 suggests suggest VBZ cord-346964-9afuen7k 265 14 that that IN cord-346964-9afuen7k 265 15 an an DT cord-346964-9afuen7k 265 16 early early JJ cord-346964-9afuen7k 265 17 transplant transplant NN cord-346964-9afuen7k 265 18 might may MD cord-346964-9afuen7k 265 19 be be VB cord-346964-9afuen7k 265 20 beneficial beneficial JJ cord-346964-9afuen7k 265 21 . . . cord-346964-9afuen7k 266 1 Diagnosis diagnosis NN cord-346964-9afuen7k 266 2 rests rest VBZ cord-346964-9afuen7k 266 3 on on IN cord-346964-9afuen7k 266 4 light light NN cord-346964-9afuen7k 266 5 and and CC cord-346964-9afuen7k 266 6 electron electron NN cord-346964-9afuen7k 266 7 microscopic microscopic JJ cord-346964-9afuen7k 266 8 examination examination NN cord-346964-9afuen7k 266 9 of of IN cord-346964-9afuen7k 266 10 small small JJ cord-346964-9afuen7k 266 11 intestinal intestinal JJ cord-346964-9afuen7k 266 12 biopsy biopsy NN cord-346964-9afuen7k 266 13 . . . cord-346964-9afuen7k 267 1 Duodenal duodenal JJ cord-346964-9afuen7k 267 2 biopsies biopsy NNS cord-346964-9afuen7k 267 3 show show VBP cord-346964-9afuen7k 267 4 moderate moderate JJ cord-346964-9afuen7k 267 5 villous villous JJ cord-346964-9afuen7k 267 6 blunting blunt VBG cord-346964-9afuen7k 267 7 , , , cord-346964-9afuen7k 267 8 with with IN cord-346964-9afuen7k 267 9 no no DT cord-346964-9afuen7k 267 10 active active JJ cord-346964-9afuen7k 267 11 inflammation inflammation NN cord-346964-9afuen7k 267 12 in in IN cord-346964-9afuen7k 267 13 the the DT cord-346964-9afuen7k 267 14 lamina lamina JJ cord-346964-9afuen7k 267 15 propria propria NN cord-346964-9afuen7k 267 16 or or CC cord-346964-9afuen7k 267 17 IELosis IELosis NNP cord-346964-9afuen7k 267 18 . . . cord-346964-9afuen7k 268 1 Changes change NNS cord-346964-9afuen7k 268 2 in in IN cord-346964-9afuen7k 268 3 the the DT cord-346964-9afuen7k 268 4 enterocytes enterocyte NNS cord-346964-9afuen7k 268 5 are be VBP cord-346964-9afuen7k 268 6 typically typically RB cord-346964-9afuen7k 268 7 found find VBN cord-346964-9afuen7k 268 8 at at IN cord-346964-9afuen7k 268 9 the the DT cord-346964-9afuen7k 268 10 villous villous JJ cord-346964-9afuen7k 268 11 tips tip NNS cord-346964-9afuen7k 268 12 rather rather RB cord-346964-9afuen7k 268 13 than than IN cord-346964-9afuen7k 268 14 villous villous JJ cord-346964-9afuen7k 268 15 bases basis NNS cord-346964-9afuen7k 268 16 and and CC cord-346964-9afuen7k 268 17 crypts crypt NNS cord-346964-9afuen7k 268 18 . . . cord-346964-9afuen7k 269 1 Light light JJ cord-346964-9afuen7k 269 2 microscopy microscopy NN cord-346964-9afuen7k 269 3 shows show VBZ cord-346964-9afuen7k 269 4 an an DT cord-346964-9afuen7k 269 5 irregular irregular JJ cord-346964-9afuen7k 269 6 vacuolated vacuolated JJ cord-346964-9afuen7k 269 7 appearance appearance NN cord-346964-9afuen7k 269 8 in in IN cord-346964-9afuen7k 269 9 the the DT cord-346964-9afuen7k 269 10 apical apical JJ cord-346964-9afuen7k 269 11 cytoplasm cytoplasm NN cord-346964-9afuen7k 269 12 of of IN cord-346964-9afuen7k 269 13 the the DT cord-346964-9afuen7k 269 14 enterocytes enterocyte NNS cord-346964-9afuen7k 269 15 with with IN cord-346964-9afuen7k 269 16 extensive extensive JJ cord-346964-9afuen7k 269 17 or or CC cord-346964-9afuen7k 269 18 patchy patchy JJ cord-346964-9afuen7k 269 19 absence absence NN cord-346964-9afuen7k 269 20 of of IN cord-346964-9afuen7k 269 21 the the DT cord-346964-9afuen7k 269 22 brush brush NN cord-346964-9afuen7k 269 23 border border NN cord-346964-9afuen7k 269 24 ( ( -LRB- cord-346964-9afuen7k 269 25 Figure Figure NNP cord-346964-9afuen7k 269 26 14(a 14(a CD cord-346964-9afuen7k 269 27 ) ) -RRB- cord-346964-9afuen7k 269 28 and and CC cord-346964-9afuen7k 269 29 14(b 14(b CD cord-346964-9afuen7k 269 30 ) ) -RRB- cord-346964-9afuen7k 269 31 ) ) -RRB- cord-346964-9afuen7k 269 32 . . . cord-346964-9afuen7k 270 1 The the DT cord-346964-9afuen7k 270 2 surface surface NN cord-346964-9afuen7k 270 3 epithelial epithelial JJ cord-346964-9afuen7k 270 4 brush brush NN cord-346964-9afuen7k 270 5 border border NN cord-346964-9afuen7k 270 6 shows show VBZ cord-346964-9afuen7k 270 7 an an DT cord-346964-9afuen7k 270 8 abnormal abnormal JJ cord-346964-9afuen7k 270 9 pattern pattern NN cord-346964-9afuen7k 270 10 of of IN cord-346964-9afuen7k 270 11 staining stain VBG cord-346964-9afuen7k 270 12 by by IN cord-346964-9afuen7k 270 13 periodic periodic JJ cord-346964-9afuen7k 270 14 acid acid NN cord-346964-9afuen7k 270 15 - - HYPH cord-346964-9afuen7k 270 16 Schiff Schiff NNP cord-346964-9afuen7k 270 17 ( ( -LRB- cord-346964-9afuen7k 270 18 PAS PAS NNP cord-346964-9afuen7k 270 19 ) ) -RRB- cord-346964-9afuen7k 270 20 and and CC cord-346964-9afuen7k 270 21 CD10 CD10 NNP cord-346964-9afuen7k 270 22 instead instead RB cord-346964-9afuen7k 270 23 of of IN cord-346964-9afuen7k 270 24 its -PRON- PRP$ cord-346964-9afuen7k 270 25 normal normal JJ cord-346964-9afuen7k 270 26 linear linear JJ cord-346964-9afuen7k 270 27 staining staining NN cord-346964-9afuen7k 270 28 pattern pattern NN cord-346964-9afuen7k 270 29 . . . cord-346964-9afuen7k 271 1 Ultrastructural ultrastructural JJ cord-346964-9afuen7k 271 2 examination examination NN cord-346964-9afuen7k 271 3 revealing reveal VBG cord-346964-9afuen7k 271 4 intracytoplasmic intracytoplasmic JJ cord-346964-9afuen7k 271 5 inclusions inclusion NNS cord-346964-9afuen7k 271 6 that that WDT cord-346964-9afuen7k 271 7 are be VBP cord-346964-9afuen7k 271 8 lined line VBN cord-346964-9afuen7k 271 9 by by IN cord-346964-9afuen7k 271 10 intact intact JJ cord-346964-9afuen7k 271 11 microvilli microvilli NN cord-346964-9afuen7k 271 12 is be VBZ cord-346964-9afuen7k 271 13 the the DT cord-346964-9afuen7k 271 14 diagnostic diagnostic JJ cord-346964-9afuen7k 271 15 hallmark hallmark NN cord-346964-9afuen7k 271 16 of of IN cord-346964-9afuen7k 271 17 the the DT cord-346964-9afuen7k 271 18 disease disease NN cord-346964-9afuen7k 271 19 ( ( -LRB- cord-346964-9afuen7k 271 20 Figure figure NN cord-346964-9afuen7k 271 21 14(c 14(c CD cord-346964-9afuen7k 271 22 ) ) -RRB- cord-346964-9afuen7k 271 23 ) ) -RRB- cord-346964-9afuen7k 271 24 . . . cord-346964-9afuen7k 272 1 These these DT cord-346964-9afuen7k 272 2 inclusions inclusion NNS cord-346964-9afuen7k 272 3 are be VBP cord-346964-9afuen7k 272 4 present present JJ cord-346964-9afuen7k 272 5 in in IN cord-346964-9afuen7k 272 6 the the DT cord-346964-9afuen7k 272 7 absorptive absorptive JJ cord-346964-9afuen7k 272 8 surface surface NN cord-346964-9afuen7k 272 9 epithelial epithelial JJ cord-346964-9afuen7k 272 10 cells cell NNS cord-346964-9afuen7k 272 11 of of IN cord-346964-9afuen7k 272 12 the the DT cord-346964-9afuen7k 272 13 small small JJ cord-346964-9afuen7k 272 14 intestine intestine NN cord-346964-9afuen7k 272 15 and and CC cord-346964-9afuen7k 272 16 are be VBP cord-346964-9afuen7k 272 17 associated associate VBN cord-346964-9afuen7k 272 18 with with IN cord-346964-9afuen7k 272 19 poorly poorly RB cord-346964-9afuen7k 272 20 developed develop VBN cord-346964-9afuen7k 272 21 surface surface NN cord-346964-9afuen7k 272 22 brush brush NN cord-346964-9afuen7k 272 23 border border NN cord-346964-9afuen7k 272 24 microvilli microvilli NN cord-346964-9afuen7k 272 25 . . . cord-346964-9afuen7k 273 1 Also also RB cord-346964-9afuen7k 273 2 known know VBN cord-346964-9afuen7k 273 3 as as IN cord-346964-9afuen7k 273 4 epithelial epithelial JJ cord-346964-9afuen7k 273 5 dysplasia dysplasia NN cord-346964-9afuen7k 273 6 , , , cord-346964-9afuen7k 273 7 congenital congenital JJ cord-346964-9afuen7k 273 8 TE TE NNP cord-346964-9afuen7k 273 9 also also RB cord-346964-9afuen7k 273 10 causes cause VBZ cord-346964-9afuen7k 273 11 severe severe JJ cord-346964-9afuen7k 273 12 diarrhea diarrhea NN cord-346964-9afuen7k 273 13 in in IN cord-346964-9afuen7k 273 14 the the DT cord-346964-9afuen7k 273 15 first first JJ cord-346964-9afuen7k 273 16 week week NN cord-346964-9afuen7k 273 17 of of IN cord-346964-9afuen7k 273 18 life life NN cord-346964-9afuen7k 273 19 together together RB cord-346964-9afuen7k 273 20 with with IN cord-346964-9afuen7k 273 21 various various JJ cord-346964-9afuen7k 273 22 dysmorphic dysmorphic JJ cord-346964-9afuen7k 273 23 features feature NNS cord-346964-9afuen7k 273 24 including include VBG cord-346964-9afuen7k 273 25 choanal choanal JJ cord-346964-9afuen7k 273 26 atresia atresia NN cord-346964-9afuen7k 273 27 and and CC cord-346964-9afuen7k 273 28 esophageal/ esophageal/ CD cord-346964-9afuen7k 273 29 rectal rectal JJ cord-346964-9afuen7k 273 30 atresia atresia NN cord-346964-9afuen7k 273 31 in in IN cord-346964-9afuen7k 273 32 some some DT cord-346964-9afuen7k 273 33 of of IN cord-346964-9afuen7k 273 34 the the DT cord-346964-9afuen7k 273 35 affected affect VBN cord-346964-9afuen7k 273 36 infants infant NNS cord-346964-9afuen7k 273 37 . . . cord-346964-9afuen7k 274 1 Though though IN cord-346964-9afuen7k 274 2 the the DT cord-346964-9afuen7k 274 3 exact exact JJ cord-346964-9afuen7k 274 4 genetic genetic JJ cord-346964-9afuen7k 274 5 abnormality abnormality NN cord-346964-9afuen7k 274 6 is be VBZ cord-346964-9afuen7k 274 7 not not RB cord-346964-9afuen7k 274 8 yet yet RB cord-346964-9afuen7k 274 9 known know VBN cord-346964-9afuen7k 274 10 , , , cord-346964-9afuen7k 275 1 EpCAM EpCAM NNP cord-346964-9afuen7k 275 2 mutations mutation NNS cord-346964-9afuen7k 275 3 on on IN cord-346964-9afuen7k 275 4 chromosome chromosome NN cord-346964-9afuen7k 275 5 2p21 2p21 CD cord-346964-9afuen7k 275 6 have have VBP cord-346964-9afuen7k 275 7 recently recently RB cord-346964-9afuen7k 275 8 been be VBN cord-346964-9afuen7k 275 9 suggested suggest VBN cord-346964-9afuen7k 275 10 as as IN cord-346964-9afuen7k 275 11 the the DT cord-346964-9afuen7k 275 12 responsible responsible JJ cord-346964-9afuen7k 275 13 genetic genetic JJ cord-346964-9afuen7k 275 14 abnormalities abnormality NNS cord-346964-9afuen7k 275 15 . . . cord-346964-9afuen7k 276 1 It -PRON- PRP cord-346964-9afuen7k 276 2 has have VBZ cord-346964-9afuen7k 276 3 been be VBN cord-346964-9afuen7k 276 4 speculated speculate VBN cord-346964-9afuen7k 276 5 that that IN cord-346964-9afuen7k 276 6 there there EX cord-346964-9afuen7k 276 7 is be VBZ cord-346964-9afuen7k 276 8 abnormal abnormal JJ cord-346964-9afuen7k 276 9 epithelial epithelial JJ cord-346964-9afuen7k 276 10 basement basement NN cord-346964-9afuen7k 276 11 membrane membrane NN cord-346964-9afuen7k 276 12 adhesion adhesion NN cord-346964-9afuen7k 276 13 in in IN cord-346964-9afuen7k 276 14 the the DT cord-346964-9afuen7k 276 15 intestinal intestinal JJ cord-346964-9afuen7k 276 16 mucosa mucosa NN cord-346964-9afuen7k 276 17 . . . cord-346964-9afuen7k 277 1 In in IN cord-346964-9afuen7k 277 2 general general JJ cord-346964-9afuen7k 277 3 , , , cord-346964-9afuen7k 277 4 infants infant NNS cord-346964-9afuen7k 277 5 with with IN cord-346964-9afuen7k 277 6 TE TE NNP cord-346964-9afuen7k 277 7 develop develop VB cord-346964-9afuen7k 277 8 watery watery JJ cord-346964-9afuen7k 277 9 diarrhea diarrhea NN cord-346964-9afuen7k 277 10 within within IN cord-346964-9afuen7k 277 11 the the DT cord-346964-9afuen7k 277 12 first first JJ cord-346964-9afuen7k 277 13 days day NNS cord-346964-9afuen7k 277 14 after after IN cord-346964-9afuen7k 277 15 birth birth NN cord-346964-9afuen7k 277 16 . . . cord-346964-9afuen7k 278 1 Stool stool NN cord-346964-9afuen7k 278 2 volumes volume NNS cord-346964-9afuen7k 278 3 may may MD cord-346964-9afuen7k 278 4 be be VB cord-346964-9afuen7k 278 5 as as RB cord-346964-9afuen7k 278 6 high high JJ cord-346964-9afuen7k 278 7 as as IN cord-346964-9afuen7k 278 8 100 100 CD cord-346964-9afuen7k 278 9 - - SYM cord-346964-9afuen7k 278 10 200 200 CD cord-346964-9afuen7k 278 11 ml ml NNS cord-346964-9afuen7k 278 12 kg kg NNP cord-346964-9afuen7k 278 13 À1 À1 NNP cord-346964-9afuen7k 278 14 body body NN cord-346964-9afuen7k 278 15 weight weight NN cord-346964-9afuen7k 278 16 per per IN cord-346964-9afuen7k 278 17 day day NN cord-346964-9afuen7k 278 18 , , , cord-346964-9afuen7k 278 19 with with IN cord-346964-9afuen7k 278 20 electrolyte electrolyte JJ cord-346964-9afuen7k 278 21 concentrations concentration NNS cord-346964-9afuen7k 278 22 similar similar JJ cord-346964-9afuen7k 278 23 to to IN cord-346964-9afuen7k 278 24 those those DT cord-346964-9afuen7k 278 25 seen see VBN cord-346964-9afuen7k 278 26 in in IN cord-346964-9afuen7k 278 27 small small JJ cord-346964-9afuen7k 278 28 intestinal intestinal JJ cord-346964-9afuen7k 278 29 fluid fluid NN cord-346964-9afuen7k 278 30 . . . cord-346964-9afuen7k 279 1 The the DT cord-346964-9afuen7k 279 2 growth growth NN cord-346964-9afuen7k 279 3 is be VBZ cord-346964-9afuen7k 279 4 impaired impaired JJ cord-346964-9afuen7k 279 5 . . . cord-346964-9afuen7k 280 1 Histology histology NN cord-346964-9afuen7k 280 2 is be VBZ cord-346964-9afuen7k 280 3 in in IN cord-346964-9afuen7k 280 4 harmony harmony NN cord-346964-9afuen7k 280 5 with with IN cord-346964-9afuen7k 280 6 the the DT cord-346964-9afuen7k 280 7 term term NN cord-346964-9afuen7k 280 8 ' ' `` cord-346964-9afuen7k 280 9 tufting tufting NN cord-346964-9afuen7k 280 10 ' ' '' cord-346964-9afuen7k 280 11 as as IN cord-346964-9afuen7k 280 12 the the DT cord-346964-9afuen7k 280 13 surface surface NN cord-346964-9afuen7k 280 14 enterocytes enterocyte NNS cord-346964-9afuen7k 280 15 display display VBP cord-346964-9afuen7k 280 16 focal focal JJ cord-346964-9afuen7k 280 17 crowding crowding NN cord-346964-9afuen7k 280 18 resembling resemble VBG cord-346964-9afuen7k 280 19 tufts tuft NNS cord-346964-9afuen7k 280 20 , , , cord-346964-9afuen7k 280 21 buds bud NNS cord-346964-9afuen7k 280 22 , , , cord-346964-9afuen7k 280 23 or or CC cord-346964-9afuen7k 280 24 small small JJ cord-346964-9afuen7k 280 25 papillae papilla NNS cord-346964-9afuen7k 280 26 , , , cord-346964-9afuen7k 280 27 some some DT cord-346964-9afuen7k 280 28 of of IN cord-346964-9afuen7k 280 29 which which WDT cord-346964-9afuen7k 280 30 seem seem VBP cord-346964-9afuen7k 280 31 to to TO cord-346964-9afuen7k 280 32 drop drop VB cord-346964-9afuen7k 280 33 off off RP cord-346964-9afuen7k 280 34 into into IN cord-346964-9afuen7k 280 35 the the DT cord-346964-9afuen7k 280 36 lumen lumen NN cord-346964-9afuen7k 280 37 on on IN cord-346964-9afuen7k 280 38 sections section NNS cord-346964-9afuen7k 280 39 ( ( -LRB- cord-346964-9afuen7k 280 40 Figure figure NN cord-346964-9afuen7k 280 41 15(a)-15(c 15(a)-15(c CD cord-346964-9afuen7k 280 42 ) ) -RRB- cord-346964-9afuen7k 280 43 ) ) -RRB- cord-346964-9afuen7k 280 44 . . . cord-346964-9afuen7k 281 1 Colonic colonic JJ cord-346964-9afuen7k 281 2 mucosa mucosa NN cord-346964-9afuen7k 281 3 may may MD cord-346964-9afuen7k 281 4 also also RB cord-346964-9afuen7k 281 5 be be VB cord-346964-9afuen7k 281 6 involved involve VBN cord-346964-9afuen7k 281 7 . . . cord-346964-9afuen7k 282 1 Deposition deposition NN cord-346964-9afuen7k 282 2 of of IN cord-346964-9afuen7k 282 3 laminin laminin NN cord-346964-9afuen7k 282 4 and and CC cord-346964-9afuen7k 282 5 heparin heparin NN cord-346964-9afuen7k 282 6 sulfate sulfate NN cord-346964-9afuen7k 282 7 in in IN cord-346964-9afuen7k 282 8 the the DT cord-346964-9afuen7k 282 9 basement basement NN cord-346964-9afuen7k 282 10 membrane membrane NN cord-346964-9afuen7k 282 11 , , , cord-346964-9afuen7k 282 12 increased increase VBN cord-346964-9afuen7k 282 13 desmoglein desmoglein NNP cord-346964-9afuen7k 282 14 expression expression NN cord-346964-9afuen7k 282 15 , , , cord-346964-9afuen7k 282 16 abnormalities abnormality NNS cord-346964-9afuen7k 282 17 in in IN cord-346964-9afuen7k 282 18 the the DT cord-346964-9afuen7k 282 19 desmosomes desmosome NNS cord-346964-9afuen7k 282 20 , , , cord-346964-9afuen7k 282 21 and and CC cord-346964-9afuen7k 282 22 abnormal abnormal JJ cord-346964-9afuen7k 282 23 distribution distribution NN cord-346964-9afuen7k 282 24 of of IN cord-346964-9afuen7k 282 25 a2b1 a2b1 JJ cord-346964-9afuen7k 282 26 integrin integrin NN cord-346964-9afuen7k 282 27 molecules molecule NNS cord-346964-9afuen7k 282 28 are be VBP cord-346964-9afuen7k 282 29 the the DT cord-346964-9afuen7k 282 30 other other JJ cord-346964-9afuen7k 282 31 features feature NNS cord-346964-9afuen7k 282 32 that that WDT cord-346964-9afuen7k 282 33 have have VBP cord-346964-9afuen7k 282 34 been be VBN cord-346964-9afuen7k 282 35 reported report VBN cord-346964-9afuen7k 282 36 . . . cord-346964-9afuen7k 283 1 This this DT cord-346964-9afuen7k 283 2 disorder disorder NN cord-346964-9afuen7k 283 3 is be VBZ cord-346964-9afuen7k 283 4 associated associate VBN cord-346964-9afuen7k 283 5 with with IN cord-346964-9afuen7k 283 6 neurogenin neurogenin NNP cord-346964-9afuen7k 283 7 3 3 CD cord-346964-9afuen7k 283 8 mutation mutation NN cord-346964-9afuen7k 283 9 , , , cord-346964-9afuen7k 283 10 which which WDT cord-346964-9afuen7k 283 11 is be VBZ cord-346964-9afuen7k 283 12 a a DT cord-346964-9afuen7k 283 13 protein protein NN cord-346964-9afuen7k 283 14 involved involve VBN cord-346964-9afuen7k 283 15 in in IN cord-346964-9afuen7k 283 16 gut gut NN cord-346964-9afuen7k 283 17 and and CC cord-346964-9afuen7k 283 18 pancreatic pancreatic JJ cord-346964-9afuen7k 283 19 endocrine endocrine JJ cord-346964-9afuen7k 283 20 cell cell NN cord-346964-9afuen7k 283 21 development development NN cord-346964-9afuen7k 283 22 , , , cord-346964-9afuen7k 283 23 located locate VBN cord-346964-9afuen7k 283 24 on on IN cord-346964-9afuen7k 283 25 chromosome chromosome NN cord-346964-9afuen7k 283 26 10q21.3 10q21.3 CD cord-346964-9afuen7k 283 27 . . . cord-346964-9afuen7k 284 1 Patients patient NNS cord-346964-9afuen7k 284 2 present present JJ cord-346964-9afuen7k 284 3 with with IN cord-346964-9afuen7k 284 4 congenital congenital JJ cord-346964-9afuen7k 284 5 diarrhea diarrhea NN cord-346964-9afuen7k 284 6 and and CC cord-346964-9afuen7k 284 7 eventually eventually RB cord-346964-9afuen7k 284 8 develop develop VB cord-346964-9afuen7k 284 9 type type NN cord-346964-9afuen7k 284 10 I -PRON- PRP cord-346964-9afuen7k 284 11 diabetes diabete VBZ cord-346964-9afuen7k 284 12 . . . cord-346964-9afuen7k 285 1 They -PRON- PRP cord-346964-9afuen7k 285 2 are be VBP cord-346964-9afuen7k 285 3 TPN tpn NN cord-346964-9afuen7k 285 4 - - HYPH cord-346964-9afuen7k 285 5 dependent dependent JJ cord-346964-9afuen7k 285 6 and and CC cord-346964-9afuen7k 285 7 may may MD cord-346964-9afuen7k 285 8 require require VB cord-346964-9afuen7k 285 9 bowel bowel NN cord-346964-9afuen7k 285 10 transplantation transplantation NN cord-346964-9afuen7k 285 11 . . . cord-346964-9afuen7k 286 1 The the DT cord-346964-9afuen7k 286 2 intestinal intestinal JJ cord-346964-9afuen7k 286 3 mucosa mucosa NN cord-346964-9afuen7k 286 4 demonstrates demonstrate VBZ cord-346964-9afuen7k 286 5 nonspecific nonspecific JJ cord-346964-9afuen7k 286 6 features feature NNS cord-346964-9afuen7k 286 7 of of IN cord-346964-9afuen7k 286 8 villous villous JJ cord-346964-9afuen7k 286 9 abnormalities abnormality NNS cord-346964-9afuen7k 286 10 , , , cord-346964-9afuen7k 286 11 whereas whereas IN cord-346964-9afuen7k 286 12 chromogranine chromogranine NN cord-346964-9afuen7k 286 13 immunostaining immunostaining NN cord-346964-9afuen7k 286 14 reveals reveal VBZ cord-346964-9afuen7k 286 15 lack lack NN cord-346964-9afuen7k 286 16 of of IN cord-346964-9afuen7k 286 17 enteroendocrine enteroendocrine JJ cord-346964-9afuen7k 286 18 cells cell NNS cord-346964-9afuen7k 286 19 in in IN cord-346964-9afuen7k 286 20 the the DT cord-346964-9afuen7k 286 21 mucosa mucosa NN cord-346964-9afuen7k 286 22 . . . cord-346964-9afuen7k 287 1 Immunodeficiency immunodeficiency NN cord-346964-9afuen7k 287 2 states state NNS cord-346964-9afuen7k 287 3 are be VBP cord-346964-9afuen7k 287 4 commonly commonly RB cord-346964-9afuen7k 287 5 associated associate VBN cord-346964-9afuen7k 287 6 with with IN cord-346964-9afuen7k 287 7 malabsorption malabsorption NN cord-346964-9afuen7k 287 8 often often RB cord-346964-9afuen7k 287 9 resulting result VBG cord-346964-9afuen7k 287 10 from from IN cord-346964-9afuen7k 287 11 opportunistic opportunistic JJ cord-346964-9afuen7k 287 12 infections infection NNS cord-346964-9afuen7k 287 13 . . . cord-346964-9afuen7k 288 1 They -PRON- PRP cord-346964-9afuen7k 288 2 may may MD cord-346964-9afuen7k 288 3 be be VB cord-346964-9afuen7k 288 4 either either CC cord-346964-9afuen7k 288 5 primary primary JJ cord-346964-9afuen7k 288 6 such such JJ cord-346964-9afuen7k 288 7 as as IN cord-346964-9afuen7k 288 8 selective selective JJ cord-346964-9afuen7k 288 9 IgA IgA NNP cord-346964-9afuen7k 288 10 deficiency deficiency NN cord-346964-9afuen7k 288 11 and and CC cord-346964-9afuen7k 288 12 common common JJ cord-346964-9afuen7k 288 13 variable variable JJ cord-346964-9afuen7k 288 14 immunodeficiency immunodeficiency NN cord-346964-9afuen7k 288 15 ( ( -LRB- cord-346964-9afuen7k 288 16 CVID CVID NNP cord-346964-9afuen7k 288 17 ) ) -RRB- cord-346964-9afuen7k 288 18 or or CC cord-346964-9afuen7k 288 19 secondary secondary JJ cord-346964-9afuen7k 288 20 including include VBG cord-346964-9afuen7k 288 21 iatrogenic iatrogenic JJ cord-346964-9afuen7k 288 22 , , , cord-346964-9afuen7k 288 23 immunoglobulin immunoglobulin JJ cord-346964-9afuen7k 288 24 loss loss NN cord-346964-9afuen7k 288 25 due due IN cord-346964-9afuen7k 288 26 to to IN cord-346964-9afuen7k 288 27 proteinlosing proteinlose VBG cord-346964-9afuen7k 288 28 enteropathy enteropathy NNP cord-346964-9afuen7k 288 29 and and CC cord-346964-9afuen7k 288 30 acquired acquire VBN cord-346964-9afuen7k 288 31 immunodeficiency immunodeficiency NN cord-346964-9afuen7k 288 32 syndrome syndrome NN cord-346964-9afuen7k 288 33 ( ( -LRB- cord-346964-9afuen7k 288 34 AIDS AIDS NNP cord-346964-9afuen7k 288 35 ) ) -RRB- cord-346964-9afuen7k 288 36 . . . cord-346964-9afuen7k 289 1 Selective selective JJ cord-346964-9afuen7k 289 2 IgA IgA NNP cord-346964-9afuen7k 289 3 deficiency deficiency NN cord-346964-9afuen7k 289 4 is be VBZ cord-346964-9afuen7k 289 5 the the DT cord-346964-9afuen7k 289 6 most most RBS cord-346964-9afuen7k 289 7 common common JJ cord-346964-9afuen7k 289 8 immunodeficiency immunodeficiency NN cord-346964-9afuen7k 289 9 in in IN cord-346964-9afuen7k 289 10 the the DT cord-346964-9afuen7k 289 11 general general JJ cord-346964-9afuen7k 289 12 population population NN cord-346964-9afuen7k 289 13 . . . cord-346964-9afuen7k 290 1 It -PRON- PRP cord-346964-9afuen7k 290 2 is be VBZ cord-346964-9afuen7k 290 3 characterized characterize VBN cord-346964-9afuen7k 290 4 by by IN cord-346964-9afuen7k 290 5 lack lack NN cord-346964-9afuen7k 290 6 of of IN cord-346964-9afuen7k 290 7 IgA IgA NNP cord-346964-9afuen7k 290 8 production production NN cord-346964-9afuen7k 290 9 , , , cord-346964-9afuen7k 290 10 major major JJ cord-346964-9afuen7k 290 11 mucosal mucosal JJ cord-346964-9afuen7k 290 12 immunoglobulin immunoglobulin NN cord-346964-9afuen7k 290 13 . . . cord-346964-9afuen7k 291 1 Patients patient NNS cord-346964-9afuen7k 291 2 have have VBP cord-346964-9afuen7k 291 3 no no DT cord-346964-9afuen7k 291 4 or or CC cord-346964-9afuen7k 291 5 very very RB cord-346964-9afuen7k 291 6 low low JJ cord-346964-9afuen7k 291 7 levels level NNS cord-346964-9afuen7k 291 8 of of IN cord-346964-9afuen7k 291 9 IgA IgA NNP cord-346964-9afuen7k 291 10 or or CC cord-346964-9afuen7k 291 11 selective selective JJ cord-346964-9afuen7k 291 12 IgA IgA NNP cord-346964-9afuen7k 291 13 in in IN cord-346964-9afuen7k 291 14 their -PRON- PRP$ cord-346964-9afuen7k 291 15 serum serum NN cord-346964-9afuen7k 291 16 but but CC cord-346964-9afuen7k 291 17 IgM IgM NNP cord-346964-9afuen7k 291 18 and and CC cord-346964-9afuen7k 291 19 IgG IgG NNP cord-346964-9afuen7k 291 20 secretion secretion NN cord-346964-9afuen7k 291 21 are be VBP cord-346964-9afuen7k 291 22 present present JJ cord-346964-9afuen7k 291 23 . . . cord-346964-9afuen7k 292 1 The the DT cord-346964-9afuen7k 292 2 disease disease NN cord-346964-9afuen7k 292 3 may may MD cord-346964-9afuen7k 292 4 be be VB cord-346964-9afuen7k 292 5 congenital congenital JJ cord-346964-9afuen7k 292 6 or or CC cord-346964-9afuen7k 292 7 induced induce VBN cord-346964-9afuen7k 292 8 by by IN cord-346964-9afuen7k 292 9 infection infection NN cord-346964-9afuen7k 292 10 or or CC cord-346964-9afuen7k 292 11 drugs drug NNS cord-346964-9afuen7k 292 12 . . . cord-346964-9afuen7k 293 1 Due due IN cord-346964-9afuen7k 293 2 to to IN cord-346964-9afuen7k 293 3 the the DT cord-346964-9afuen7k 293 4 absence absence NN cord-346964-9afuen7k 293 5 of of IN cord-346964-9afuen7k 293 6 IgA IgA NNP cord-346964-9afuen7k 293 7 , , , cord-346964-9afuen7k 293 8 B b NN cord-346964-9afuen7k 293 9 - - HYPH cord-346964-9afuen7k 293 10 cell cell NN cord-346964-9afuen7k 293 11 maturation maturation NN cord-346964-9afuen7k 293 12 is be VBZ cord-346964-9afuen7k 293 13 defective defective JJ cord-346964-9afuen7k 293 14 , , , cord-346964-9afuen7k 293 15 while while IN cord-346964-9afuen7k 293 16 some some DT cord-346964-9afuen7k 293 17 patients patient NNS cord-346964-9afuen7k 293 18 may may MD cord-346964-9afuen7k 293 19 also also RB cord-346964-9afuen7k 293 20 have have VB cord-346964-9afuen7k 293 21 T t NN cord-346964-9afuen7k 293 22 - - HYPH cord-346964-9afuen7k 293 23 cell cell NN cord-346964-9afuen7k 293 24 abnormalities abnormality NNS cord-346964-9afuen7k 293 25 . . . cord-346964-9afuen7k 294 1 Accordingly accordingly RB cord-346964-9afuen7k 294 2 , , , cord-346964-9afuen7k 294 3 IgA IgA NNP cord-346964-9afuen7k 294 4 - - HYPH cord-346964-9afuen7k 294 5 containing contain VBG cord-346964-9afuen7k 294 6 plasma plasma NN cord-346964-9afuen7k 294 7 cells cell NNS cord-346964-9afuen7k 294 8 , , , cord-346964-9afuen7k 294 9 but but CC cord-346964-9afuen7k 294 10 not not RB cord-346964-9afuen7k 294 11 others other NNS cord-346964-9afuen7k 294 12 , , , cord-346964-9afuen7k 294 13 are be VBP cord-346964-9afuen7k 294 14 absent absent JJ cord-346964-9afuen7k 294 15 in in IN cord-346964-9afuen7k 294 16 the the DT cord-346964-9afuen7k 294 17 mucosa mucosa NN cord-346964-9afuen7k 294 18 . . . cord-346964-9afuen7k 295 1 Most Most JJS cord-346964-9afuen7k 295 2 common common JJ cord-346964-9afuen7k 295 3 clinical clinical JJ cord-346964-9afuen7k 295 4 features feature NNS cord-346964-9afuen7k 295 5 are be VBP cord-346964-9afuen7k 295 6 diarrhea diarrhea NN cord-346964-9afuen7k 295 7 , , , cord-346964-9afuen7k 295 8 malabsorption malabsorption NN cord-346964-9afuen7k 295 9 , , , cord-346964-9afuen7k 295 10 and and CC cord-346964-9afuen7k 295 11 bacterial bacterial JJ cord-346964-9afuen7k 295 12 infections infection NNS cord-346964-9afuen7k 295 13 . . . cord-346964-9afuen7k 296 1 Mucosa Mucosa NNP cord-346964-9afuen7k 296 2 is be VBZ cord-346964-9afuen7k 296 3 usually usually RB cord-346964-9afuen7k 296 4 normal normal JJ cord-346964-9afuen7k 296 5 , , , cord-346964-9afuen7k 296 6 though though IN cord-346964-9afuen7k 296 7 completely completely RB cord-346964-9afuen7k 296 8 flat flat JJ cord-346964-9afuen7k 296 9 mucosa mucosa NN cord-346964-9afuen7k 296 10 can can MD cord-346964-9afuen7k 296 11 be be VB cord-346964-9afuen7k 296 12 found find VBN cord-346964-9afuen7k 296 13 in in IN cord-346964-9afuen7k 296 14 some some DT cord-346964-9afuen7k 296 15 patients patient NNS cord-346964-9afuen7k 296 16 . . . cord-346964-9afuen7k 297 1 CVID CVID NNP cord-346964-9afuen7k 297 2 is be VBZ cord-346964-9afuen7k 297 3 the the DT cord-346964-9afuen7k 297 4 second second JJ cord-346964-9afuen7k 297 5 most most RBS cord-346964-9afuen7k 297 6 common common JJ cord-346964-9afuen7k 297 7 immunodeficiency immunodeficiency NN cord-346964-9afuen7k 297 8 syndrome syndrome NN cord-346964-9afuen7k 297 9 after after IN cord-346964-9afuen7k 297 10 selective selective JJ cord-346964-9afuen7k 297 11 IgA IgA NNP cord-346964-9afuen7k 297 12 deficiency deficiency NN cord-346964-9afuen7k 297 13 . . . cord-346964-9afuen7k 298 1 This this DT cord-346964-9afuen7k 298 2 is be VBZ cord-346964-9afuen7k 298 3 not not RB cord-346964-9afuen7k 298 4 a a DT cord-346964-9afuen7k 298 5 single single JJ cord-346964-9afuen7k 298 6 entity entity NN cord-346964-9afuen7k 298 7 but but CC cord-346964-9afuen7k 298 8 a a DT cord-346964-9afuen7k 298 9 group group NN cord-346964-9afuen7k 298 10 of of IN cord-346964-9afuen7k 298 11 conditions condition NNS cord-346964-9afuen7k 298 12 . . . cord-346964-9afuen7k 299 1 With with IN cord-346964-9afuen7k 299 2 various various JJ cord-346964-9afuen7k 299 3 underlying underlying JJ cord-346964-9afuen7k 299 4 abnormalities abnormality NNS cord-346964-9afuen7k 299 5 , , , cord-346964-9afuen7k 299 6 many many JJ cord-346964-9afuen7k 299 7 of of IN cord-346964-9afuen7k 299 8 them -PRON- PRP cord-346964-9afuen7k 299 9 are be VBP cord-346964-9afuen7k 299 10 immune immune JJ cord-346964-9afuen7k 299 11 regulatory regulatory JJ cord-346964-9afuen7k 299 12 , , , cord-346964-9afuen7k 299 13 including include VBG cord-346964-9afuen7k 299 14 hyperactive hyperactive JJ cord-346964-9afuen7k 299 15 T t NN cord-346964-9afuen7k 299 16 - - HYPH cord-346964-9afuen7k 299 17 cell cell NN cord-346964-9afuen7k 299 18 suppression suppression NN cord-346964-9afuen7k 299 19 or or CC cord-346964-9afuen7k 299 20 reduced reduce VBN cord-346964-9afuen7k 299 21 T t NN cord-346964-9afuen7k 299 22 - - HYPH cord-346964-9afuen7k 299 23 helper helper NN cord-346964-9afuen7k 299 24 function function NN cord-346964-9afuen7k 299 25 . . . cord-346964-9afuen7k 300 1 CVI CVI NNP cord-346964-9afuen7k 300 2 appears appear VBZ cord-346964-9afuen7k 300 3 after after IN cord-346964-9afuen7k 300 4 infancy infancy NN cord-346964-9afuen7k 300 5 and and CC cord-346964-9afuen7k 300 6 often often RB cord-346964-9afuen7k 300 7 is be VBZ cord-346964-9afuen7k 300 8 first first RB cord-346964-9afuen7k 300 9 discovered discover VBN cord-346964-9afuen7k 300 10 in in IN cord-346964-9afuen7k 300 11 adulthood adulthood NN cord-346964-9afuen7k 300 12 . . . cord-346964-9afuen7k 301 1 There there EX cord-346964-9afuen7k 301 2 is be VBZ cord-346964-9afuen7k 301 3 variable variable JJ cord-346964-9afuen7k 301 4 deficiency deficiency NN cord-346964-9afuen7k 301 5 of of IN cord-346964-9afuen7k 301 6 IgA IgA NNP cord-346964-9afuen7k 301 7 , , , cord-346964-9afuen7k 301 8 lgM lgM NNP cord-346964-9afuen7k 301 9 , , , cord-346964-9afuen7k 301 10 and and CC cord-346964-9afuen7k 301 11 IgG IgG NNP cord-346964-9afuen7k 301 12 , , , cord-346964-9afuen7k 301 13 but but CC cord-346964-9afuen7k 301 14 IgA IgA NNP cord-346964-9afuen7k 301 15 production production NNP cord-346964-9afuen7k 301 16 and and CC cord-346964-9afuen7k 301 17 IgM IgM NNP cord-346964-9afuen7k 301 18 production production NN cord-346964-9afuen7k 301 19 are be VBP cord-346964-9afuen7k 301 20 typically typically RB cord-346964-9afuen7k 301 21 reduced reduce VBN cord-346964-9afuen7k 301 22 or or CC cord-346964-9afuen7k 301 23 absent absent JJ cord-346964-9afuen7k 301 24 . . . cord-346964-9afuen7k 302 1 It -PRON- PRP cord-346964-9afuen7k 302 2 is be VBZ cord-346964-9afuen7k 302 3 primarily primarily RB cord-346964-9afuen7k 302 4 a a DT cord-346964-9afuen7k 302 5 dysfunction dysfunction NN cord-346964-9afuen7k 302 6 of of IN cord-346964-9afuen7k 302 7 B b NN cord-346964-9afuen7k 302 8 - - HYPH cord-346964-9afuen7k 302 9 cell cell NN cord-346964-9afuen7k 302 10 differentiation differentiation NN cord-346964-9afuen7k 302 11 resulting result VBG cord-346964-9afuen7k 302 12 in in IN cord-346964-9afuen7k 302 13 hypogammaglobulinemia hypogammaglobulinemia NN cord-346964-9afuen7k 302 14 and and CC cord-346964-9afuen7k 302 15 diminished diminished JJ cord-346964-9afuen7k 302 16 ability ability NN cord-346964-9afuen7k 302 17 to to TO cord-346964-9afuen7k 302 18 produce produce VB cord-346964-9afuen7k 302 19 antibodies antibody NNS cord-346964-9afuen7k 302 20 . . . cord-346964-9afuen7k 303 1 Patients patient NNS cord-346964-9afuen7k 303 2 present present JJ cord-346964-9afuen7k 303 3 with with IN cord-346964-9afuen7k 303 4 diarrhea diarrhea NN cord-346964-9afuen7k 303 5 and and CC cord-346964-9afuen7k 303 6 recurrent recurrent JJ cord-346964-9afuen7k 303 7 chronic chronic JJ cord-346964-9afuen7k 303 8 infections infection NNS cord-346964-9afuen7k 303 9 . . . cord-346964-9afuen7k 304 1 It -PRON- PRP cord-346964-9afuen7k 304 2 is be VBZ cord-346964-9afuen7k 304 3 characterized characterize VBN cord-346964-9afuen7k 304 4 by by IN cord-346964-9afuen7k 304 5 a a DT cord-346964-9afuen7k 304 6 paucity paucity NN cord-346964-9afuen7k 304 7 or or CC cord-346964-9afuen7k 304 8 absence absence NN cord-346964-9afuen7k 304 9 of of IN cord-346964-9afuen7k 304 10 plasma plasma NN cord-346964-9afuen7k 304 11 cells cell NNS cord-346964-9afuen7k 304 12 in in IN cord-346964-9afuen7k 304 13 the the DT cord-346964-9afuen7k 304 14 lamina lamina JJ cord-346964-9afuen7k 304 15 propria propria NN cord-346964-9afuen7k 304 16 despite despite IN cord-346964-9afuen7k 304 17 its -PRON- PRP$ cord-346964-9afuen7k 304 18 normal normal JJ cord-346964-9afuen7k 304 19 lymphocytic lymphocytic JJ cord-346964-9afuen7k 304 20 content content NN cord-346964-9afuen7k 304 21 usually usually RB cord-346964-9afuen7k 304 22 in in IN cord-346964-9afuen7k 304 23 the the DT cord-346964-9afuen7k 304 24 form form NN cord-346964-9afuen7k 304 25 of of IN cord-346964-9afuen7k 304 26 lymphoid lymphoid JJ cord-346964-9afuen7k 304 27 aggregates aggregate NNS cord-346964-9afuen7k 304 28 and and CC cord-346964-9afuen7k 304 29 IELosis ielosis NN cord-346964-9afuen7k 304 30 in in IN cord-346964-9afuen7k 304 31 the the DT cord-346964-9afuen7k 304 32 surface surface NN cord-346964-9afuen7k 304 33 epithelium epithelium NN cord-346964-9afuen7k 304 34 . . . cord-346964-9afuen7k 305 1 Increased increase VBN cord-346964-9afuen7k 305 2 apoptosis apoptosis NN cord-346964-9afuen7k 305 3 is be VBZ cord-346964-9afuen7k 305 4 also also RB cord-346964-9afuen7k 305 5 a a DT cord-346964-9afuen7k 305 6 common common JJ cord-346964-9afuen7k 305 7 feature feature NN cord-346964-9afuen7k 305 8 , , , cord-346964-9afuen7k 305 9 while while IN cord-346964-9afuen7k 305 10 in in IN cord-346964-9afuen7k 305 11 a a DT cord-346964-9afuen7k 305 12 small small JJ cord-346964-9afuen7k 305 13 percentage percentage NN cord-346964-9afuen7k 305 14 of of IN cord-346964-9afuen7k 305 15 the the DT cord-346964-9afuen7k 305 16 cases case NNS cord-346964-9afuen7k 305 17 , , , cord-346964-9afuen7k 305 18 granulomas granuloma NNS cord-346964-9afuen7k 305 19 may may MD cord-346964-9afuen7k 305 20 be be VB cord-346964-9afuen7k 305 21 present present JJ cord-346964-9afuen7k 305 22 in in IN cord-346964-9afuen7k 305 23 the the DT cord-346964-9afuen7k 305 24 lamina lamina JJ cord-346964-9afuen7k 305 25 propria propria NN cord-346964-9afuen7k 305 26 . . . cord-346964-9afuen7k 306 1 The the DT cord-346964-9afuen7k 306 2 mucosa mucosa NN cord-346964-9afuen7k 306 3 may may MD cord-346964-9afuen7k 306 4 also also RB cord-346964-9afuen7k 306 5 harbor harbor VB cord-346964-9afuen7k 306 6 infectious infectious JJ cord-346964-9afuen7k 306 7 agents agent NNS cord-346964-9afuen7k 306 8 such such JJ cord-346964-9afuen7k 306 9 as as IN cord-346964-9afuen7k 306 10 Giardia Giardia NNP cord-346964-9afuen7k 306 11 , , , cord-346964-9afuen7k 306 12 Cryptosporidium cryptosporidium NN cord-346964-9afuen7k 306 13 , , , cord-346964-9afuen7k 306 14 and and CC cord-346964-9afuen7k 306 15 microsporidia microsporidia NNP cord-346964-9afuen7k 306 16 resulting result VBG cord-346964-9afuen7k 306 17 from from IN cord-346964-9afuen7k 306 18 the the DT cord-346964-9afuen7k 306 19 immunodeficient immunodeficient JJ cord-346964-9afuen7k 306 20 state state NN cord-346964-9afuen7k 306 21 . . . cord-346964-9afuen7k 307 1 Gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 307 2 complications complication NNS cord-346964-9afuen7k 307 3 are be VBP cord-346964-9afuen7k 307 4 common common JJ cord-346964-9afuen7k 307 5 in in IN cord-346964-9afuen7k 307 6 bone bone NN cord-346964-9afuen7k 307 7 marrow marrow NN cord-346964-9afuen7k 307 8 transplant transplant NN cord-346964-9afuen7k 307 9 recipients recipient NNS cord-346964-9afuen7k 307 10 rather rather RB cord-346964-9afuen7k 307 11 than than IN cord-346964-9afuen7k 307 12 solid solid JJ cord-346964-9afuen7k 307 13 organ organ NN cord-346964-9afuen7k 307 14 transplantation transplantation NN cord-346964-9afuen7k 307 15 . . . cord-346964-9afuen7k 308 1 The the DT cord-346964-9afuen7k 308 2 main main JJ cord-346964-9afuen7k 308 3 cause cause NN cord-346964-9afuen7k 308 4 of of IN cord-346964-9afuen7k 308 5 these these DT cord-346964-9afuen7k 308 6 complications complication NNS cord-346964-9afuen7k 308 7 comprises comprise VBZ cord-346964-9afuen7k 308 8 GVHD GVHD NNP cord-346964-9afuen7k 308 9 , , , cord-346964-9afuen7k 308 10 infections infection NNS cord-346964-9afuen7k 308 11 , , , cord-346964-9afuen7k 308 12 toxicity toxicity NN cord-346964-9afuen7k 308 13 of of IN cord-346964-9afuen7k 308 14 medication medication NN cord-346964-9afuen7k 308 15 , , , cord-346964-9afuen7k 308 16 and and CC cord-346964-9afuen7k 308 17 preexisting preexisting JJ cord-346964-9afuen7k 308 18 GI GI NNP cord-346964-9afuen7k 308 19 disease disease NN cord-346964-9afuen7k 308 20 . . . cord-346964-9afuen7k 309 1 Patients patient NNS cord-346964-9afuen7k 309 2 suffering suffer VBG cord-346964-9afuen7k 309 3 from from IN cord-346964-9afuen7k 309 4 acute acute JJ cord-346964-9afuen7k 309 5 GVHD GVHD NNP cord-346964-9afuen7k 309 6 are be VBP cord-346964-9afuen7k 309 7 at at IN cord-346964-9afuen7k 309 8 higher high JJR cord-346964-9afuen7k 309 9 risk risk NN cord-346964-9afuen7k 309 10 for for IN cord-346964-9afuen7k 309 11 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 309 12 infections infection NNS cord-346964-9afuen7k 309 13 . . . cord-346964-9afuen7k 310 1 Donor donor NN cord-346964-9afuen7k 310 2 T t NN cord-346964-9afuen7k 310 3 cells cell NNS cord-346964-9afuen7k 310 4 of of IN cord-346964-9afuen7k 310 5 cytotoxic cytotoxic JJ cord-346964-9afuen7k 310 6 subtype subtype NN cord-346964-9afuen7k 310 7 incite incite VBP cord-346964-9afuen7k 310 8 an an DT cord-346964-9afuen7k 310 9 immunologic immunologic JJ cord-346964-9afuen7k 310 10 reaction reaction NN cord-346964-9afuen7k 310 11 to to IN cord-346964-9afuen7k 310 12 certain certain JJ cord-346964-9afuen7k 310 13 host host NN cord-346964-9afuen7k 310 14 cells cell NNS cord-346964-9afuen7k 310 15 resulting result VBG cord-346964-9afuen7k 310 16 in in IN cord-346964-9afuen7k 310 17 injury injury NN cord-346964-9afuen7k 310 18 to to IN cord-346964-9afuen7k 310 19 GI GI NNP cord-346964-9afuen7k 310 20 mucosa mucosa NN cord-346964-9afuen7k 310 21 . . . cord-346964-9afuen7k 311 1 Patients patient NNS cord-346964-9afuen7k 311 2 with with IN cord-346964-9afuen7k 311 3 GVHD GVHD NNP cord-346964-9afuen7k 311 4 present present JJ cord-346964-9afuen7k 311 5 with with IN cord-346964-9afuen7k 311 6 secretory secretory JJ cord-346964-9afuen7k 311 7 diarrhea diarrhea NN cord-346964-9afuen7k 311 8 and and CC cord-346964-9afuen7k 311 9 abdominal abdominal JJ cord-346964-9afuen7k 311 10 pain pain NN cord-346964-9afuen7k 311 11 and and CC cord-346964-9afuen7k 311 12 at at IN cord-346964-9afuen7k 311 13 times time NNS cord-346964-9afuen7k 311 14 hemorrhage hemorrhage NN cord-346964-9afuen7k 311 15 . . . cord-346964-9afuen7k 312 1 Upper upper JJ cord-346964-9afuen7k 312 2 GI GI NNP cord-346964-9afuen7k 312 3 involvement involvement NN cord-346964-9afuen7k 312 4 is be VBZ cord-346964-9afuen7k 312 5 more more RBR cord-346964-9afuen7k 312 6 common common JJ cord-346964-9afuen7k 312 7 in in IN cord-346964-9afuen7k 312 8 children child NNS cord-346964-9afuen7k 312 9 , , , cord-346964-9afuen7k 312 10 while while IN cord-346964-9afuen7k 312 11 colonic colonic JJ cord-346964-9afuen7k 312 12 involvement involvement NN cord-346964-9afuen7k 312 13 is be VBZ cord-346964-9afuen7k 312 14 usually usually RB cord-346964-9afuen7k 312 15 more more RBR cord-346964-9afuen7k 312 16 severe severe JJ cord-346964-9afuen7k 312 17 than than IN cord-346964-9afuen7k 312 18 small small JJ cord-346964-9afuen7k 312 19 intestinal intestinal JJ cord-346964-9afuen7k 312 20 disease disease NN cord-346964-9afuen7k 312 21 . . . cord-346964-9afuen7k 313 1 Malabsorption malabsorption NN cord-346964-9afuen7k 313 2 may may MD cord-346964-9afuen7k 313 3 develop develop VB cord-346964-9afuen7k 313 4 when when WRB cord-346964-9afuen7k 313 5 small small JJ cord-346964-9afuen7k 313 6 intestinal intestinal JJ cord-346964-9afuen7k 313 7 mucosa mucosa NN cord-346964-9afuen7k 313 8 is be VBZ cord-346964-9afuen7k 313 9 severely severely RB cord-346964-9afuen7k 313 10 damaged damage VBN cord-346964-9afuen7k 313 11 . . . cord-346964-9afuen7k 314 1 Microscopic microscopic JJ cord-346964-9afuen7k 314 2 findings finding NNS cord-346964-9afuen7k 314 3 vary vary VBP cord-346964-9afuen7k 314 4 from from IN cord-346964-9afuen7k 314 5 damage damage NN cord-346964-9afuen7k 314 6 to to IN cord-346964-9afuen7k 314 7 individual individual JJ cord-346964-9afuen7k 314 8 epithelial epithelial JJ cord-346964-9afuen7k 314 9 cell cell NN cord-346964-9afuen7k 314 10 in in IN cord-346964-9afuen7k 314 11 the the DT cord-346964-9afuen7k 314 12 form form NN cord-346964-9afuen7k 314 13 of of IN cord-346964-9afuen7k 314 14 apoptosis apoptosis NN cord-346964-9afuen7k 314 15 to to TO cord-346964-9afuen7k 314 16 total total VB cord-346964-9afuen7k 314 17 mucosal mucosal JJ cord-346964-9afuen7k 314 18 ulceration ulceration NN cord-346964-9afuen7k 314 19 and and CC cord-346964-9afuen7k 314 20 are be VBP cord-346964-9afuen7k 314 21 graded grade VBN cord-346964-9afuen7k 314 22 according accord VBG cord-346964-9afuen7k 314 23 to to IN cord-346964-9afuen7k 314 24 Snover Snover NNP cord-346964-9afuen7k 314 25 's 's POS cord-346964-9afuen7k 314 26 criteria criterion NNS cord-346964-9afuen7k 314 27 ( ( -LRB- cord-346964-9afuen7k 314 28 Table table NN cord-346964-9afuen7k 314 29 6 6 CD cord-346964-9afuen7k 314 30 ) ) -RRB- cord-346964-9afuen7k 314 31 . . . cord-346964-9afuen7k 315 1 Deficiencies deficiency NNS cord-346964-9afuen7k 315 2 associated associate VBN cord-346964-9afuen7k 315 3 with with IN cord-346964-9afuen7k 315 4 carbohydrates carbohydrate NNS cord-346964-9afuen7k 315 5 , , , cord-346964-9afuen7k 315 6 amino amino JJ cord-346964-9afuen7k 315 7 acids acid NNS cord-346964-9afuen7k 315 8 , , , cord-346964-9afuen7k 315 9 electrolytes electrolyte NNS cord-346964-9afuen7k 315 10 , , , cord-346964-9afuen7k 315 11 and and CC cord-346964-9afuen7k 315 12 vitamins vitamin NNS cord-346964-9afuen7k 315 13 are be VBP cord-346964-9afuen7k 315 14 rarely rarely RB cord-346964-9afuen7k 315 15 biopsied biopsie VBN cord-346964-9afuen7k 315 16 as as IN cord-346964-9afuen7k 315 17 the the DT cord-346964-9afuen7k 315 18 intestinal intestinal JJ cord-346964-9afuen7k 315 19 mucosa mucosa NN cord-346964-9afuen7k 315 20 is be VBZ cord-346964-9afuen7k 315 21 either either CC cord-346964-9afuen7k 315 22 normal normal JJ cord-346964-9afuen7k 315 23 or or CC cord-346964-9afuen7k 315 24 only only RB cord-346964-9afuen7k 315 25 slightly slightly RB cord-346964-9afuen7k 315 26 abnormal abnormal JJ cord-346964-9afuen7k 315 27 , , , cord-346964-9afuen7k 315 28 while while IN cord-346964-9afuen7k 315 29 deficiencies deficiency NNS cord-346964-9afuen7k 315 30 of of IN cord-346964-9afuen7k 315 31 lipid lipid NN cord-346964-9afuen7k 315 32 transport transport NN cord-346964-9afuen7k 315 33 cause cause NN cord-346964-9afuen7k 315 34 abnormalities abnormality NNS cord-346964-9afuen7k 315 35 in in IN cord-346964-9afuen7k 315 36 the the DT cord-346964-9afuen7k 315 37 intestinal intestinal JJ cord-346964-9afuen7k 315 38 mucosa mucosa NN cord-346964-9afuen7k 315 39 . . . cord-346964-9afuen7k 316 1 Among among IN cord-346964-9afuen7k 316 2 the the DT cord-346964-9afuen7k 316 3 latter latter JJ cord-346964-9afuen7k 316 4 , , , cord-346964-9afuen7k 316 5 abeta abeta NNP cord-346964-9afuen7k 316 6 / / SYM cord-346964-9afuen7k 316 7 hypobetalipoproteinemia hypobetalipoproteinemia NNP cord-346964-9afuen7k 316 8 and and CC cord-346964-9afuen7k 316 9 chylomicron chylomicron NNP cord-346964-9afuen7k 316 10 retention retention NNP cord-346964-9afuen7k 316 11 disease disease NN cord-346964-9afuen7k 316 12 are be VBP cord-346964-9afuen7k 316 13 the the DT cord-346964-9afuen7k 316 14 most most RBS cord-346964-9afuen7k 316 15 commonly commonly RB cord-346964-9afuen7k 316 16 encountered encounter VBN cord-346964-9afuen7k 316 17 disorders disorder NNS cord-346964-9afuen7k 316 18 in in IN cord-346964-9afuen7k 316 19 infants infant NNS cord-346964-9afuen7k 316 20 with with IN cord-346964-9afuen7k 316 21 malabsorption malabsorption NN cord-346964-9afuen7k 316 22 . . . cord-346964-9afuen7k 317 1 The the DT cord-346964-9afuen7k 317 2 patients patient NNS cord-346964-9afuen7k 317 3 suffer suffer VBP cord-346964-9afuen7k 317 4 from from IN cord-346964-9afuen7k 317 5 diarrhea diarrhea NN cord-346964-9afuen7k 317 6 and and CC cord-346964-9afuen7k 317 7 fat fat JJ cord-346964-9afuen7k 317 8 malabsorption malabsorption NN cord-346964-9afuen7k 317 9 with with IN cord-346964-9afuen7k 317 10 low low JJ cord-346964-9afuen7k 317 11 serum serum NN cord-346964-9afuen7k 317 12 cholesterol cholesterol NN cord-346964-9afuen7k 317 13 and and CC cord-346964-9afuen7k 317 14 triglycerides triglyceride NNS cord-346964-9afuen7k 317 15 and and CC cord-346964-9afuen7k 317 16 peripheral peripheral JJ cord-346964-9afuen7k 317 17 acanthocytosis acanthocytosi NNS cord-346964-9afuen7k 317 18 . . . cord-346964-9afuen7k 318 1 Duodenal duodenal JJ cord-346964-9afuen7k 318 2 mucosa mucosa JJ cord-346964-9afuen7k 318 3 shows show VBZ cord-346964-9afuen7k 318 4 lipid lipid NN cord-346964-9afuen7k 318 5 vacuolization vacuolization NN cord-346964-9afuen7k 318 6 of of IN cord-346964-9afuen7k 318 7 surface surface NN cord-346964-9afuen7k 318 8 enterocytes enterocyte NNS cord-346964-9afuen7k 318 9 with with IN cord-346964-9afuen7k 318 10 preserved preserve VBN cord-346964-9afuen7k 318 11 villous villous NNP cord-346964-9afuen7k 318 12 architecture architecture NN cord-346964-9afuen7k 319 1 ( ( -LRB- cord-346964-9afuen7k 319 2 Figure figure NN cord-346964-9afuen7k 319 3 16 16 CD cord-346964-9afuen7k 319 4 ( ( -LRB- cord-346964-9afuen7k 319 5 a)-16(c a)-16(c NN cord-346964-9afuen7k 319 6 ) ) -RRB- cord-346964-9afuen7k 319 7 ) ) -RRB- cord-346964-9afuen7k 319 8 . . . cord-346964-9afuen7k 320 1 It -PRON- PRP cord-346964-9afuen7k 320 2 is be VBZ cord-346964-9afuen7k 320 3 an an DT cord-346964-9afuen7k 320 4 autosomal autosomal JJ cord-346964-9afuen7k 320 5 recessive recessive JJ cord-346964-9afuen7k 320 6 disease disease NN cord-346964-9afuen7k 320 7 characterized characterize VBN cord-346964-9afuen7k 320 8 by by IN cord-346964-9afuen7k 320 9 the the DT cord-346964-9afuen7k 320 10 absence absence NN cord-346964-9afuen7k 320 11 of of IN cord-346964-9afuen7k 320 12 apolipoprotein apolipoprotein NN cord-346964-9afuen7k 320 13 B b NN cord-346964-9afuen7k 320 14 ( ( -LRB- cord-346964-9afuen7k 320 15 apoB apob NN cord-346964-9afuen7k 320 16 ) ) -RRB- cord-346964-9afuen7k 320 17 , , , cord-346964-9afuen7k 320 18 the the DT cord-346964-9afuen7k 320 19 transport transport NN cord-346964-9afuen7k 320 20 protein protein NN cord-346964-9afuen7k 320 21 of of IN cord-346964-9afuen7k 320 22 dietary dietary JJ cord-346964-9afuen7k 320 23 fat fat NN cord-346964-9afuen7k 320 24 from from IN cord-346964-9afuen7k 320 25 the the DT cord-346964-9afuen7k 320 26 small small JJ cord-346964-9afuen7k 320 27 intestinal intestinal JJ cord-346964-9afuen7k 320 28 mucosa mucosa RB cord-346964-9afuen7k 320 29 into into IN cord-346964-9afuen7k 320 30 the the DT cord-346964-9afuen7k 320 31 bloodstream bloodstream NN cord-346964-9afuen7k 320 32 . . . cord-346964-9afuen7k 321 1 Mutations mutation NNS cord-346964-9afuen7k 321 2 in in IN cord-346964-9afuen7k 321 3 microsomal microsomal NNP cord-346964-9afuen7k 321 4 triglyceride triglyceride NN cord-346964-9afuen7k 321 5 transfer transfer NN cord-346964-9afuen7k 321 6 protein protein NN cord-346964-9afuen7k 321 7 ( ( -LRB- cord-346964-9afuen7k 321 8 MTP MTP NNP cord-346964-9afuen7k 321 9 ) ) -RRB- cord-346964-9afuen7k 321 10 located locate VBN cord-346964-9afuen7k 321 11 in in IN cord-346964-9afuen7k 321 12 4q22-q24 4q22-q24 JJ cord-346964-9afuen7k 321 13 result result NN cord-346964-9afuen7k 321 14 in in IN cord-346964-9afuen7k 321 15 defective defective JJ cord-346964-9afuen7k 321 16 lipid lipid NN cord-346964-9afuen7k 321 17 transfer transfer NN cord-346964-9afuen7k 321 18 from from IN cord-346964-9afuen7k 321 19 endoplasmic endoplasmic NN cord-346964-9afuen7k 321 20 reticulum reticulum NN cord-346964-9afuen7k 321 21 to to IN cord-346964-9afuen7k 321 22 apoB apoB . cord-346964-9afuen7k 322 1 ( ( -LRB- cord-346964-9afuen7k 322 2 Figure Figure NNP cord-346964-9afuen7k 322 3 17 17 CD cord-346964-9afuen7k 322 4 ) ) -RRB- cord-346964-9afuen7k 322 5 . . . cord-346964-9afuen7k 323 1 SAR1B SAR1B . cord-346964-9afuen7k 324 1 gene gene NN cord-346964-9afuen7k 324 2 encoding encode VBG cord-346964-9afuen7k 324 3 protein protein NN cord-346964-9afuen7k 324 4 carrier carrier NN cord-346964-9afuen7k 324 5 GTPase GTPase NNP cord-346964-9afuen7k 325 1 located locate VBN cord-346964-9afuen7k 325 2 in in IN cord-346964-9afuen7k 325 3 5q31 5q31 CD cord-346964-9afuen7k 325 4 is be VBZ cord-346964-9afuen7k 325 5 mutated mutate VBN cord-346964-9afuen7k 325 6 in in IN cord-346964-9afuen7k 325 7 chylomicron chylomicron NNP cord-346964-9afuen7k 325 8 retention retention NN cord-346964-9afuen7k 325 9 disease disease NN cord-346964-9afuen7k 325 10 . . . cord-346964-9afuen7k 326 1 Lipid lipid NN cord-346964-9afuen7k 326 2 assembly assembly NN cord-346964-9afuen7k 326 3 is be VBZ cord-346964-9afuen7k 326 4 disorganized disorganized JJ cord-346964-9afuen7k 326 5 in in IN cord-346964-9afuen7k 326 6 both both DT cord-346964-9afuen7k 326 7 of of IN cord-346964-9afuen7k 326 8 these these DT cord-346964-9afuen7k 326 9 disorders disorder NNS cord-346964-9afuen7k 326 10 resulting result VBG cord-346964-9afuen7k 326 11 in in IN cord-346964-9afuen7k 326 12 low low JJ cord-346964-9afuen7k 326 13 levels level NNS cord-346964-9afuen7k 326 14 of of IN cord-346964-9afuen7k 326 15 serum serum NN cord-346964-9afuen7k 326 16 lipids lipid NNS cord-346964-9afuen7k 326 17 accompanied accompany VBN cord-346964-9afuen7k 326 18 by by IN cord-346964-9afuen7k 326 19 various various JJ cord-346964-9afuen7k 326 20 Table Table NNP cord-346964-9afuen7k 326 21 6 6 CD cord-346964-9afuen7k 326 22 Grading grading NN cord-346964-9afuen7k 326 23 of of IN cord-346964-9afuen7k 326 24 mucosal mucosal JJ cord-346964-9afuen7k 326 25 changes change NNS cord-346964-9afuen7k 326 26 in in IN cord-346964-9afuen7k 326 27 GVHD GVHD NNP cord-346964-9afuen7k 326 28 ( ( -LRB- cord-346964-9afuen7k 326 29 Snover Snover NNP cord-346964-9afuen7k 326 30 ) ) -RRB- cord-346964-9afuen7k 326 31 Grade grade NN cord-346964-9afuen7k 326 32 1 1 CD cord-346964-9afuen7k 326 33 Grade grade NN cord-346964-9afuen7k 326 34 2 2 CD cord-346964-9afuen7k 326 35 Grade Grade NNP cord-346964-9afuen7k 326 36 3 3 CD cord-346964-9afuen7k 326 37 Grade Grade NNP cord-346964-9afuen7k 326 38 4 4 CD cord-346964-9afuen7k 326 39 Crypt Crypt NNP cord-346964-9afuen7k 326 40 epithelial epithelial JJ cord-346964-9afuen7k 326 41 cell cell NN cord-346964-9afuen7k 326 42 apoptosis apoptosis NN cord-346964-9afuen7k 326 43 Apoptosis apoptosis NN cord-346964-9afuen7k 326 44 with with IN cord-346964-9afuen7k 326 45 crypt crypt NN cord-346964-9afuen7k 326 46 abscess abscess NN cord-346964-9afuen7k 327 1 Individual individual JJ cord-346964-9afuen7k 327 2 crypt crypt NN cord-346964-9afuen7k 327 3 loss loss NN cord-346964-9afuen7k 327 4 Total total JJ cord-346964-9afuen7k 327 5 mucosal mucosal JJ cord-346964-9afuen7k 327 6 denudation denudation NN cord-346964-9afuen7k 327 7 neurological neurological JJ cord-346964-9afuen7k 327 8 manifestations manifestation NNS cord-346964-9afuen7k 327 9 due due JJ cord-346964-9afuen7k 327 10 to to IN cord-346964-9afuen7k 327 11 malabsorption malabsorption NN cord-346964-9afuen7k 327 12 of of IN cord-346964-9afuen7k 327 13 fatsoluble fatsoluble JJ cord-346964-9afuen7k 327 14 vitamins vitamin NNS cord-346964-9afuen7k 327 15 , , , cord-346964-9afuen7k 327 16 particularly particularly RB cord-346964-9afuen7k 327 17 vitamins vitamin NNS cord-346964-9afuen7k 327 18 E e NN cord-346964-9afuen7k 327 19 and and CC cord-346964-9afuen7k 327 20 A. a. JJ cord-346964-9afuen7k 327 21 Intestinal intestinal JJ cord-346964-9afuen7k 327 22 lymphangiectasia lymphangiectasia NN cord-346964-9afuen7k 327 23 is be VBZ cord-346964-9afuen7k 327 24 defined define VBN cord-346964-9afuen7k 327 25 as as IN cord-346964-9afuen7k 327 26 the the DT cord-346964-9afuen7k 327 27 presence presence NN cord-346964-9afuen7k 327 28 of of IN cord-346964-9afuen7k 327 29 dilated dilated JJ cord-346964-9afuen7k 327 30 lymphatics lymphatic NNS cord-346964-9afuen7k 327 31 within within IN cord-346964-9afuen7k 327 32 the the DT cord-346964-9afuen7k 327 33 intestinal intestinal JJ cord-346964-9afuen7k 327 34 mucosa mucosa NN cord-346964-9afuen7k 327 35 . . . cord-346964-9afuen7k 328 1 The the DT cord-346964-9afuen7k 328 2 form form NN cord-346964-9afuen7k 328 3 , , , cord-346964-9afuen7k 328 4 known know VBN cord-346964-9afuen7k 328 5 as as IN cord-346964-9afuen7k 328 6 secondary secondary JJ cord-346964-9afuen7k 328 7 intestinal intestinal JJ cord-346964-9afuen7k 328 8 lymphangiectasia lymphangiectasia NNS cord-346964-9afuen7k 328 9 , , , cord-346964-9afuen7k 328 10 is be VBZ cord-346964-9afuen7k 328 11 associated associate VBN cord-346964-9afuen7k 328 12 with with IN cord-346964-9afuen7k 328 13 a a DT cord-346964-9afuen7k 328 14 local local JJ cord-346964-9afuen7k 328 15 neoplastic neoplastic JJ cord-346964-9afuen7k 328 16 or or CC cord-346964-9afuen7k 328 17 inflammatory inflammatory JJ cord-346964-9afuen7k 328 18 condition condition NN cord-346964-9afuen7k 328 19 causing cause VBG cord-346964-9afuen7k 328 20 lymphatic lymphatic JJ cord-346964-9afuen7k 328 21 obstruction obstruction NN cord-346964-9afuen7k 328 22 . . . cord-346964-9afuen7k 329 1 Conditions condition NNS cord-346964-9afuen7k 329 2 associated associate VBN cord-346964-9afuen7k 329 3 with with IN cord-346964-9afuen7k 329 4 secondary secondary JJ cord-346964-9afuen7k 329 5 intestinal intestinal JJ cord-346964-9afuen7k 329 6 lymphangiectasia lymphangiectasia NNS cord-346964-9afuen7k 329 7 include include VBP cord-346964-9afuen7k 329 8 lymphoma lymphoma NN cord-346964-9afuen7k 329 9 , , , cord-346964-9afuen7k 329 10 carcinoma carcinoma NN cord-346964-9afuen7k 329 11 , , , cord-346964-9afuen7k 329 12 Crohn Crohn NNP cord-346964-9afuen7k 329 13 's 's POS cord-346964-9afuen7k 329 14 disease disease NN cord-346964-9afuen7k 329 15 , , , cord-346964-9afuen7k 329 16 systemic systemic JJ cord-346964-9afuen7k 329 17 lupus lupus NN cord-346964-9afuen7k 329 18 erythematosus erythematosus NN cord-346964-9afuen7k 329 19 , , , cord-346964-9afuen7k 329 20 Behçet Behçet NNP cord-346964-9afuen7k 329 21 's 's POS cord-346964-9afuen7k 329 22 disease disease NN cord-346964-9afuen7k 329 23 , , , cord-346964-9afuen7k 329 24 trauma trauma NN cord-346964-9afuen7k 329 25 , , , cord-346964-9afuen7k 329 26 cardiac cardiac JJ cord-346964-9afuen7k 329 27 disorders disorder NNS cord-346964-9afuen7k 329 28 , , , cord-346964-9afuen7k 329 29 and and CC cord-346964-9afuen7k 329 30 complications complication NNS cord-346964-9afuen7k 329 31 after after IN cord-346964-9afuen7k 329 32 liver liver NN cord-346964-9afuen7k 329 33 transplantation transplantation NN cord-346964-9afuen7k 329 34 and and CC cord-346964-9afuen7k 329 35 radiation radiation NN cord-346964-9afuen7k 329 36 therapy therapy NN cord-346964-9afuen7k 329 37 . . . cord-346964-9afuen7k 330 1 Secondary secondary JJ cord-346964-9afuen7k 330 2 form form NN cord-346964-9afuen7k 330 3 affects affect VBZ cord-346964-9afuen7k 330 4 one one CD cord-346964-9afuen7k 330 5 side side NN cord-346964-9afuen7k 330 6 of of IN cord-346964-9afuen7k 330 7 the the DT cord-346964-9afuen7k 330 8 body body NN cord-346964-9afuen7k 330 9 resulting result VBG cord-346964-9afuen7k 330 10 in in IN cord-346964-9afuen7k 330 11 unilateral unilateral JJ cord-346964-9afuen7k 330 12 edema edema NN cord-346964-9afuen7k 330 13 but but CC cord-346964-9afuen7k 330 14 not not RB cord-346964-9afuen7k 330 15 protein protein NN cord-346964-9afuen7k 330 16 - - HYPH cord-346964-9afuen7k 330 17 losing lose VBG cord-346964-9afuen7k 330 18 enteropathy enteropathy NNP cord-346964-9afuen7k 330 19 . . . cord-346964-9afuen7k 331 1 Primary primary JJ cord-346964-9afuen7k 331 2 intestinal intestinal JJ cord-346964-9afuen7k 331 3 lymphangiectasia lymphangiectasia NNS cord-346964-9afuen7k 331 4 , , , cord-346964-9afuen7k 331 5 on on IN cord-346964-9afuen7k 331 6 the the DT cord-346964-9afuen7k 331 7 other other JJ cord-346964-9afuen7k 331 8 hand hand NN cord-346964-9afuen7k 331 9 , , , cord-346964-9afuen7k 331 10 is be VBZ cord-346964-9afuen7k 331 11 a a DT cord-346964-9afuen7k 331 12 rare rare JJ cord-346964-9afuen7k 331 13 congenital congenital JJ cord-346964-9afuen7k 331 14 disorder disorder NN cord-346964-9afuen7k 331 15 characterized characterize VBN cord-346964-9afuen7k 331 16 by by IN cord-346964-9afuen7k 331 17 severe severe JJ cord-346964-9afuen7k 331 18 protein protein NN cord-346964-9afuen7k 331 19 - - HYPH cord-346964-9afuen7k 331 20 losing lose VBG cord-346964-9afuen7k 331 21 enteropathy enteropathy NN cord-346964-9afuen7k 331 22 , , , cord-346964-9afuen7k 331 23 peripheral peripheral JJ cord-346964-9afuen7k 331 24 edema edema NN cord-346964-9afuen7k 331 25 , , , cord-346964-9afuen7k 331 26 steatorrhea steatorrhea NN cord-346964-9afuen7k 331 27 , , , cord-346964-9afuen7k 331 28 chylous chylous JJ cord-346964-9afuen7k 331 29 effusion effusion NN cord-346964-9afuen7k 331 30 and and CC cord-346964-9afuen7k 331 31 lymphocytopenia lymphocytopenia NNP cord-346964-9afuen7k 331 32 , , , cord-346964-9afuen7k 331 33 growth growth NN cord-346964-9afuen7k 331 34 retardation retardation NN cord-346964-9afuen7k 331 35 , , , cord-346964-9afuen7k 331 36 and and CC cord-346964-9afuen7k 331 37 severe severe JJ cord-346964-9afuen7k 331 38 hypoalbuminemia hypoalbuminemia NN cord-346964-9afuen7k 331 39 . . . cord-346964-9afuen7k 332 1 There there EX cord-346964-9afuen7k 332 2 is be VBZ cord-346964-9afuen7k 332 3 a a DT cord-346964-9afuen7k 332 4 major major JJ cord-346964-9afuen7k 332 5 structural structural JJ cord-346964-9afuen7k 332 6 abnormality abnormality NN cord-346964-9afuen7k 332 7 of of IN cord-346964-9afuen7k 332 8 the the DT cord-346964-9afuen7k 332 9 lymphatic lymphatic JJ cord-346964-9afuen7k 332 10 system system NN cord-346964-9afuen7k 332 11 consisting consist VBG cord-346964-9afuen7k 332 12 of of IN cord-346964-9afuen7k 332 13 dilatation dilatation NN cord-346964-9afuen7k 332 14 and and CC cord-346964-9afuen7k 332 15 tortuosity tortuosity NN cord-346964-9afuen7k 332 16 of of IN cord-346964-9afuen7k 332 17 lymphatic lymphatic JJ cord-346964-9afuen7k 332 18 vessels vessel NNS cord-346964-9afuen7k 332 19 resulting result VBG cord-346964-9afuen7k 332 20 in in IN cord-346964-9afuen7k 332 21 lymphatic lymphatic JJ cord-346964-9afuen7k 332 22 stasis stasis NN cord-346964-9afuen7k 332 23 in in IN cord-346964-9afuen7k 332 24 the the DT cord-346964-9afuen7k 332 25 intestinal intestinal JJ cord-346964-9afuen7k 332 26 wall wall NN cord-346964-9afuen7k 332 27 . . . cord-346964-9afuen7k 333 1 The the DT cord-346964-9afuen7k 333 2 resultant resultant JJ cord-346964-9afuen7k 333 3 lymph lymph NN cord-346964-9afuen7k 333 4 leakage leakage NN cord-346964-9afuen7k 333 5 causes cause NNS cord-346964-9afuen7k 333 6 loss loss NN cord-346964-9afuen7k 333 7 of of IN cord-346964-9afuen7k 333 8 proteins protein NNS cord-346964-9afuen7k 333 9 , , , cord-346964-9afuen7k 333 10 vitamins vitamin NNS cord-346964-9afuen7k 333 11 , , , cord-346964-9afuen7k 333 12 and and CC cord-346964-9afuen7k 333 13 other other JJ cord-346964-9afuen7k 333 14 nutrients nutrient NNS cord-346964-9afuen7k 333 15 . . . cord-346964-9afuen7k 334 1 Protein protein NN cord-346964-9afuen7k 334 2 loss loss NN cord-346964-9afuen7k 334 3 also also RB cord-346964-9afuen7k 334 4 causes cause VBZ cord-346964-9afuen7k 334 5 immunoglobulin immunoglobulin NN cord-346964-9afuen7k 334 6 deficiency deficiency NN cord-346964-9afuen7k 334 7 resulting result VBG cord-346964-9afuen7k 334 8 in in IN cord-346964-9afuen7k 334 9 an an DT cord-346964-9afuen7k 334 10 immunodeficient immunodeficient JJ cord-346964-9afuen7k 334 11 state state NN cord-346964-9afuen7k 334 12 . . . cord-346964-9afuen7k 335 1 Primary primary JJ cord-346964-9afuen7k 335 2 form form NN cord-346964-9afuen7k 335 3 is be VBZ cord-346964-9afuen7k 335 4 usually usually RB cord-346964-9afuen7k 335 5 diagnosed diagnose VBN cord-346964-9afuen7k 335 6 before before IN cord-346964-9afuen7k 335 7 the the DT cord-346964-9afuen7k 335 8 age age NN cord-346964-9afuen7k 335 9 of of IN cord-346964-9afuen7k 335 10 3 3 CD cord-346964-9afuen7k 335 11 years year NNS cord-346964-9afuen7k 335 12 . . . cord-346964-9afuen7k 336 1 Though though IN cord-346964-9afuen7k 336 2 entire entire JJ cord-346964-9afuen7k 336 3 small small JJ cord-346964-9afuen7k 336 4 intestine intestine NN cord-346964-9afuen7k 336 5 can can MD cord-346964-9afuen7k 336 6 be be VB cord-346964-9afuen7k 336 7 involved involve VBN cord-346964-9afuen7k 336 8 , , , cord-346964-9afuen7k 336 9 duodenum duodenum NN cord-346964-9afuen7k 336 10 is be VBZ cord-346964-9afuen7k 336 11 the the DT cord-346964-9afuen7k 336 12 most most RBS cord-346964-9afuen7k 336 13 commonly commonly RB cord-346964-9afuen7k 336 14 affected affect VBN cord-346964-9afuen7k 336 15 part part NN cord-346964-9afuen7k 336 16 of of IN cord-346964-9afuen7k 336 17 small small JJ cord-346964-9afuen7k 336 18 intestine intestine NN cord-346964-9afuen7k 336 19 . . . cord-346964-9afuen7k 337 1 The the DT cord-346964-9afuen7k 337 2 mucosa mucosa NN cord-346964-9afuen7k 337 3 shows show VBZ cord-346964-9afuen7k 337 4 features feature NNS cord-346964-9afuen7k 337 5 of of IN cord-346964-9afuen7k 337 6 lymphangiectasia lymphangiectasia NNS cord-346964-9afuen7k 337 7 on on IN cord-346964-9afuen7k 337 8 endoscopy endoscopy NN cord-346964-9afuen7k 337 9 as as IN cord-346964-9afuen7k 337 10 numerous numerous JJ cord-346964-9afuen7k 337 11 white white JJ cord-346964-9afuen7k 337 12 spots spot NNS cord-346964-9afuen7k 337 13 or or CC cord-346964-9afuen7k 337 14 nodules nodule NNS cord-346964-9afuen7k 337 15 that that WDT cord-346964-9afuen7k 337 16 correspond correspond VBP cord-346964-9afuen7k 337 17 to to IN cord-346964-9afuen7k 337 18 the the DT cord-346964-9afuen7k 337 19 dilated dilated JJ cord-346964-9afuen7k 337 20 lymphatics lymphatic NNS cord-346964-9afuen7k 337 21 in in IN cord-346964-9afuen7k 337 22 superficial superficial JJ cord-346964-9afuen7k 337 23 mucosa mucosa NN cord-346964-9afuen7k 337 24 involving involve VBG cord-346964-9afuen7k 337 25 the the DT cord-346964-9afuen7k 337 26 villus villus NN cord-346964-9afuen7k 337 27 tips tip NNS cord-346964-9afuen7k 337 28 with with IN cord-346964-9afuen7k 337 29 formation formation NN cord-346964-9afuen7k 337 30 of of IN cord-346964-9afuen7k 337 31 ' ' `` cord-346964-9afuen7k 337 32 lacteals lacteal NNS cord-346964-9afuen7k 337 33 ' ' '' cord-346964-9afuen7k 337 34 ( ( -LRB- cord-346964-9afuen7k 337 35 Figure figure NN cord-346964-9afuen7k 337 36 18(a 18(a CD cord-346964-9afuen7k 337 37 ) ) -RRB- cord-346964-9afuen7k 337 38 and and CC cord-346964-9afuen7k 337 39 18(b 18(b LS cord-346964-9afuen7k 337 40 ) ) -RRB- cord-346964-9afuen7k 337 41 ) ) -RRB- cord-346964-9afuen7k 337 42 . . . cord-346964-9afuen7k 338 1 These these DT cord-346964-9afuen7k 338 2 are be VBP cord-346964-9afuen7k 338 3 dilated dilated JJ cord-346964-9afuen7k 338 4 lymphatic lymphatic JJ cord-346964-9afuen7k 338 5 vessels vessel NNS cord-346964-9afuen7k 338 6 with with IN cord-346964-9afuen7k 338 7 endothelial endothelial JJ cord-346964-9afuen7k 338 8 lining lining NN cord-346964-9afuen7k 338 9 and and CC cord-346964-9afuen7k 338 10 pale pale JJ cord-346964-9afuen7k 338 11 basophilic basophilic NN cord-346964-9afuen7k 338 12 material material NN cord-346964-9afuen7k 338 13 of of IN cord-346964-9afuen7k 338 14 lymph lymph NN cord-346964-9afuen7k 338 15 fluid fluid NN cord-346964-9afuen7k 338 16 in in IN cord-346964-9afuen7k 338 17 their -PRON- PRP$ cord-346964-9afuen7k 338 18 lumen lumen NN cord-346964-9afuen7k 338 19 . . . cord-346964-9afuen7k 339 1 Infectious infectious JJ cord-346964-9afuen7k 339 2 agents agent NNS cord-346964-9afuen7k 339 3 that that WDT cord-346964-9afuen7k 339 4 affect affect VBP cord-346964-9afuen7k 339 5 the the DT cord-346964-9afuen7k 339 6 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 339 7 tract tract NN cord-346964-9afuen7k 339 8 can can MD cord-346964-9afuen7k 339 9 be be VB cord-346964-9afuen7k 339 10 grouped group VBN cord-346964-9afuen7k 339 11 as as IN cord-346964-9afuen7k 339 12 food food NN cord-346964-9afuen7k 339 13 - - HYPH cord-346964-9afuen7k 339 14 borne bear VBN cord-346964-9afuen7k 339 15 and and CC cord-346964-9afuen7k 339 16 water water NN cord-346964-9afuen7k 339 17 - - HYPH cord-346964-9afuen7k 339 18 borne bear VBN cord-346964-9afuen7k 339 19 bacteria bacteria NNS cord-346964-9afuen7k 339 20 , , , cord-346964-9afuen7k 339 21 opportunistic opportunistic JJ cord-346964-9afuen7k 339 22 infections infection NNS cord-346964-9afuen7k 339 23 ( ( -LRB- cord-346964-9afuen7k 339 24 bacterial bacterial JJ cord-346964-9afuen7k 339 25 , , , cord-346964-9afuen7k 339 26 fungal fungal JJ cord-346964-9afuen7k 339 27 , , , cord-346964-9afuen7k 339 28 and and CC cord-346964-9afuen7k 339 29 viral viral JJ cord-346964-9afuen7k 339 30 ) ) -RRB- cord-346964-9afuen7k 339 31 , , , cord-346964-9afuen7k 339 32 viral viral JJ cord-346964-9afuen7k 339 33 infections infection NNS cord-346964-9afuen7k 339 34 ( ( -LRB- cord-346964-9afuen7k 339 35 extremely extremely RB cord-346964-9afuen7k 339 36 rarely rarely RB cord-346964-9afuen7k 339 37 biopsied biopsied JJ cord-346964-9afuen7k 339 38 ) ) -RRB- cord-346964-9afuen7k 339 39 , , , cord-346964-9afuen7k 339 40 and and CC cord-346964-9afuen7k 339 41 parasitic parasitic JJ cord-346964-9afuen7k 339 42 and and CC cord-346964-9afuen7k 339 43 helminthic helminthic JJ cord-346964-9afuen7k 339 44 infections infection NNS cord-346964-9afuen7k 339 45 . . . cord-346964-9afuen7k 340 1 The the DT cord-346964-9afuen7k 340 2 majority majority NN cord-346964-9afuen7k 340 3 of of IN cord-346964-9afuen7k 340 4 these these DT cord-346964-9afuen7k 340 5 infections infection NNS cord-346964-9afuen7k 340 6 are be VBP cord-346964-9afuen7k 340 7 , , , cord-346964-9afuen7k 340 8 however however RB cord-346964-9afuen7k 340 9 , , , cord-346964-9afuen7k 340 10 selflimited selflimited JJ cord-346964-9afuen7k 340 11 . . . cord-346964-9afuen7k 341 1 Those those DT cord-346964-9afuen7k 341 2 patients patient NNS cord-346964-9afuen7k 341 3 that that WDT cord-346964-9afuen7k 341 4 undergo undergo VBP cord-346964-9afuen7k 341 5 endoscopic endoscopic JJ cord-346964-9afuen7k 341 6 biopsy biopsy NN cord-346964-9afuen7k 341 7 often often RB cord-346964-9afuen7k 341 8 have have VBP cord-346964-9afuen7k 341 9 chronic chronic JJ cord-346964-9afuen7k 341 10 or or CC cord-346964-9afuen7k 341 11 debilitating debilitating JJ cord-346964-9afuen7k 341 12 diarrhea diarrhea NN cord-346964-9afuen7k 341 13 , , , cord-346964-9afuen7k 341 14 or or CC cord-346964-9afuen7k 341 15 malabsorption malabsorption NN cord-346964-9afuen7k 341 16 leading lead VBG cord-346964-9afuen7k 341 17 to to IN cord-346964-9afuen7k 341 18 systemic systemic JJ cord-346964-9afuen7k 341 19 symptoms symptom NNS cord-346964-9afuen7k 341 20 , , , cord-346964-9afuen7k 341 21 or or CC cord-346964-9afuen7k 341 22 a a DT cord-346964-9afuen7k 341 23 history history NN cord-346964-9afuen7k 341 24 of of IN cord-346964-9afuen7k 341 25 immunocompromise immunocompromise NNP cord-346964-9afuen7k 341 26 or or CC cord-346964-9afuen7k 341 27 other other JJ cord-346964-9afuen7k 341 28 significant significant JJ cord-346964-9afuen7k 341 29 clinical clinical JJ cord-346964-9afuen7k 341 30 scenarios scenario NNS cord-346964-9afuen7k 341 31 . . . cord-346964-9afuen7k 342 1 Clinicopathologic clinicopathologic JJ cord-346964-9afuen7k 342 2 information information NN cord-346964-9afuen7k 342 3 regarding regard VBG cord-346964-9afuen7k 342 4 exact exact JJ cord-346964-9afuen7k 342 5 symptomatology symptomatology NN cord-346964-9afuen7k 342 6 and and CC cord-346964-9afuen7k 342 7 colonoscopic colonoscopic JJ cord-346964-9afuen7k 342 8 findings finding NNS cord-346964-9afuen7k 342 9 , , , cord-346964-9afuen7k 342 10 as as RB cord-346964-9afuen7k 342 11 well well RB cord-346964-9afuen7k 342 12 as as IN cord-346964-9afuen7k 342 13 facts fact NNS cord-346964-9afuen7k 342 14 including include VBG cord-346964-9afuen7k 342 15 travel travel NN cord-346964-9afuen7k 342 16 history history NN cord-346964-9afuen7k 342 17 , , , cord-346964-9afuen7k 342 18 food food NN cord-346964-9afuen7k 342 19 intake intake NN cord-346964-9afuen7k 342 20 ( ( -LRB- cord-346964-9afuen7k 342 21 such such JJ cord-346964-9afuen7k 342 22 as as IN cord-346964-9afuen7k 342 23 sushi sushi JJ cord-346964-9afuen7k 342 24 or or CC cord-346964-9afuen7k 342 25 poorly poorly RB cord-346964-9afuen7k 342 26 cooked cook VBN cord-346964-9afuen7k 342 27 beef beef NN cord-346964-9afuen7k 342 28 ) ) -RRB- cord-346964-9afuen7k 342 29 , , , cord-346964-9afuen7k 342 30 sexual sexual JJ cord-346964-9afuen7k 342 31 practices practice NNS cord-346964-9afuen7k 342 32 , , , cord-346964-9afuen7k 342 33 and and CC cord-346964-9afuen7k 342 34 immune immune JJ cord-346964-9afuen7k 342 35 status status NN cord-346964-9afuen7k 342 36 , , , cord-346964-9afuen7k 342 37 can can MD cord-346964-9afuen7k 342 38 greatly greatly RB cord-346964-9afuen7k 342 39 aid aid VB cord-346964-9afuen7k 342 40 in in IN cord-346964-9afuen7k 342 41 the the DT cord-346964-9afuen7k 342 42 diagnosis diagnosis NN cord-346964-9afuen7k 342 43 . . . cord-346964-9afuen7k 343 1 Ancillary ancillary JJ cord-346964-9afuen7k 343 2 techniques technique NNS cord-346964-9afuen7k 343 3 including include VBG cord-346964-9afuen7k 343 4 histochemistry histochemistry NN cord-346964-9afuen7k 343 5 , , , cord-346964-9afuen7k 343 6 immunohistochemistry immunohistochemistry NN cord-346964-9afuen7k 343 7 , , , cord-346964-9afuen7k 343 8 and and CC cord-346964-9afuen7k 343 9 molecular molecular JJ cord-346964-9afuen7k 343 10 methods method NNS cord-346964-9afuen7k 343 11 like like IN cord-346964-9afuen7k 343 12 in in IN cord-346964-9afuen7k 343 13 situ situ NN cord-346964-9afuen7k 343 14 hybridization hybridization NN cord-346964-9afuen7k 343 15 and and CC cord-346964-9afuen7k 343 16 PCR PCR NNP cord-346964-9afuen7k 343 17 can can MD cord-346964-9afuen7k 343 18 increase increase VB cord-346964-9afuen7k 343 19 diagnostic diagnostic JJ cord-346964-9afuen7k 343 20 accuracy accuracy NN cord-346964-9afuen7k 343 21 . . . cord-346964-9afuen7k 344 1 Gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 344 2 infections infection NNS cord-346964-9afuen7k 344 3 can can MD cord-346964-9afuen7k 344 4 cause cause VB cord-346964-9afuen7k 344 5 mucosal mucosal JJ cord-346964-9afuen7k 344 6 inflammation inflammation NN cord-346964-9afuen7k 344 7 that that WDT cord-346964-9afuen7k 344 8 represents represent VBZ cord-346964-9afuen7k 344 9 various various JJ cord-346964-9afuen7k 344 10 patterns pattern NNS cord-346964-9afuen7k 344 11 of of IN cord-346964-9afuen7k 344 12 tissue tissue NN cord-346964-9afuen7k 344 13 response response NN cord-346964-9afuen7k 344 14 . . . cord-346964-9afuen7k 345 1 Histological histological JJ cord-346964-9afuen7k 345 2 patterns pattern NNS cord-346964-9afuen7k 345 3 of of IN cord-346964-9afuen7k 345 4 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 345 5 infections infection NNS cord-346964-9afuen7k 345 6 are be VBP cord-346964-9afuen7k 345 7 summarized summarize VBN cord-346964-9afuen7k 345 8 in in IN cord-346964-9afuen7k 345 9 Table Table NNP cord-346964-9afuen7k 345 10 7 7 CD cord-346964-9afuen7k 345 11 . . . cord-346964-9afuen7k 346 1 Though though IN cord-346964-9afuen7k 346 2 these these DT cord-346964-9afuen7k 346 3 patterns pattern NNS cord-346964-9afuen7k 346 4 can can MD cord-346964-9afuen7k 346 5 be be VB cord-346964-9afuen7k 346 6 observed observe VBN cord-346964-9afuen7k 346 7 in in IN cord-346964-9afuen7k 346 8 any any DT cord-346964-9afuen7k 346 9 part part NN cord-346964-9afuen7k 346 10 of of IN cord-346964-9afuen7k 346 11 the the DT cord-346964-9afuen7k 346 12 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 346 13 system system NN cord-346964-9afuen7k 346 14 , , , cord-346964-9afuen7k 346 15 there there EX cord-346964-9afuen7k 346 16 are be VBP cord-346964-9afuen7k 346 17 some some DT cord-346964-9afuen7k 346 18 organ-/sitespecific organ-/sitespecific JJ cord-346964-9afuen7k 346 19 findings finding NNS cord-346964-9afuen7k 346 20 of of IN cord-346964-9afuen7k 346 21 infectious infectious JJ cord-346964-9afuen7k 346 22 diseases disease NNS cord-346964-9afuen7k 346 23 . . . cord-346964-9afuen7k 347 1 A a DT cord-346964-9afuen7k 347 2 wide wide JJ cord-346964-9afuen7k 347 3 variety variety NN cord-346964-9afuen7k 347 4 of of IN cord-346964-9afuen7k 347 5 infectious infectious JJ cord-346964-9afuen7k 347 6 agents agent NNS cord-346964-9afuen7k 347 7 including include VBG cord-346964-9afuen7k 347 8 , , , cord-346964-9afuen7k 347 9 viruses virus NNS cord-346964-9afuen7k 347 10 , , , cord-346964-9afuen7k 347 11 parasites parasite NNS cord-346964-9afuen7k 347 12 , , , cord-346964-9afuen7k 347 13 and and CC cord-346964-9afuen7k 347 14 bacteria bacteria NNS cord-346964-9afuen7k 347 15 can can MD cord-346964-9afuen7k 347 16 affect affect VB cord-346964-9afuen7k 347 17 small small JJ cord-346964-9afuen7k 347 18 intestinal intestinal JJ cord-346964-9afuen7k 347 19 mucosa mucosa NN cord-346964-9afuen7k 347 20 . . . cord-346964-9afuen7k 348 1 Endoscopic endoscopic JJ cord-346964-9afuen7k 348 2 picture picture NN cord-346964-9afuen7k 348 3 may may MD cord-346964-9afuen7k 348 4 vary vary VB cord-346964-9afuen7k 348 5 between between IN cord-346964-9afuen7k 348 6 erythema erythema NN cord-346964-9afuen7k 348 7 and and CC cord-346964-9afuen7k 348 8 granularity granularity NN cord-346964-9afuen7k 348 9 to to IN cord-346964-9afuen7k 348 10 erosions erosion NNS cord-346964-9afuen7k 348 11 and and CC cord-346964-9afuen7k 348 12 ulcerations ulceration NNS cord-346964-9afuen7k 348 13 . . . cord-346964-9afuen7k 349 1 The the DT cord-346964-9afuen7k 349 2 majority majority NN cord-346964-9afuen7k 349 3 of of IN cord-346964-9afuen7k 349 4 infections infection NNS cord-346964-9afuen7k 349 5 cause cause VBP cord-346964-9afuen7k 349 6 only only RB cord-346964-9afuen7k 349 7 mild mild JJ cord-346964-9afuen7k 349 8 and and CC cord-346964-9afuen7k 349 9 nonspecific nonspecific JJ cord-346964-9afuen7k 349 10 alterations alteration NNS cord-346964-9afuen7k 349 11 in in IN cord-346964-9afuen7k 349 12 the the DT cord-346964-9afuen7k 349 13 intestinal intestinal JJ cord-346964-9afuen7k 349 14 mucosa mucosa NN cord-346964-9afuen7k 349 15 including include VBG cord-346964-9afuen7k 349 16 , , , cord-346964-9afuen7k 349 17 IELosis ielosis NN cord-346964-9afuen7k 349 18 , , , cord-346964-9afuen7k 349 19 lamina lamina JJ cord-346964-9afuen7k 349 20 propria propria NN cord-346964-9afuen7k 349 21 inflammation inflammation NN cord-346964-9afuen7k 349 22 , , , cord-346964-9afuen7k 349 23 and and CC cord-346964-9afuen7k 349 24 rarely rarely RB cord-346964-9afuen7k 349 25 architectural architectural JJ cord-346964-9afuen7k 349 26 changes change NNS cord-346964-9afuen7k 349 27 , , , cord-346964-9afuen7k 349 28 while while IN cord-346964-9afuen7k 349 29 some some DT cord-346964-9afuen7k 349 30 can can MD cord-346964-9afuen7k 349 31 be be VB cord-346964-9afuen7k 349 32 diagnosed diagnose VBN cord-346964-9afuen7k 349 33 by by IN cord-346964-9afuen7k 349 34 identifying identify VBG cord-346964-9afuen7k 349 35 the the DT cord-346964-9afuen7k 349 36 microorganism microorganism NN cord-346964-9afuen7k 349 37 in in IN cord-346964-9afuen7k 349 38 biopsy biopsy NN cord-346964-9afuen7k 349 39 specimens specimen NNS cord-346964-9afuen7k 349 40 such such JJ cord-346964-9afuen7k 349 41 as as IN cord-346964-9afuen7k 349 42 giardiasis giardiasis NN cord-346964-9afuen7k 349 43 , , , cord-346964-9afuen7k 349 44 Whipple Whipple NNP cord-346964-9afuen7k 349 45 's 's POS cord-346964-9afuen7k 349 46 disease disease NN cord-346964-9afuen7k 349 47 ( ( -LRB- cord-346964-9afuen7k 349 48 WD WD NNP cord-346964-9afuen7k 349 49 ) ) -RRB- cord-346964-9afuen7k 349 50 , , , cord-346964-9afuen7k 349 51 and and CC cord-346964-9afuen7k 349 52 opportunistic opportunistic JJ cord-346964-9afuen7k 349 53 infections infection NNS cord-346964-9afuen7k 349 54 including include VBG cord-346964-9afuen7k 349 55 microsporidiosis microsporidiosis NNP cord-346964-9afuen7k 349 56 , , , cord-346964-9afuen7k 349 57 cryptosporidiosis cryptosporidiosis NNP cord-346964-9afuen7k 349 58 , , , cord-346964-9afuen7k 349 59 and and CC cord-346964-9afuen7k 349 60 cytomegalovirus cytomegalovirus NNP cord-346964-9afuen7k 349 61 ( ( -LRB- cord-346964-9afuen7k 349 62 CMV CMV NNP cord-346964-9afuen7k 349 63 ) ) -RRB- cord-346964-9afuen7k 349 64 infection infection NN cord-346964-9afuen7k 349 65 . . . cord-346964-9afuen7k 350 1 The the DT cord-346964-9afuen7k 350 2 general general JJ cord-346964-9afuen7k 350 3 pathogenetic pathogenetic JJ cord-346964-9afuen7k 350 4 mechanism mechanism NN cord-346964-9afuen7k 350 5 shared share VBN cord-346964-9afuen7k 350 6 by by IN cord-346964-9afuen7k 350 7 many many JJ cord-346964-9afuen7k 350 8 small small JJ cord-346964-9afuen7k 350 9 intestinal intestinal JJ cord-346964-9afuen7k 350 10 infections infection NNS cord-346964-9afuen7k 350 11 depends depend VBZ cord-346964-9afuen7k 350 12 on on IN cord-346964-9afuen7k 350 13 the the DT cord-346964-9afuen7k 350 14 interaction interaction NN cord-346964-9afuen7k 350 15 of of IN cord-346964-9afuen7k 350 16 the the DT cord-346964-9afuen7k 350 17 infectious infectious JJ cord-346964-9afuen7k 350 18 agent agent NN cord-346964-9afuen7k 350 19 with with IN cord-346964-9afuen7k 350 20 the the DT cord-346964-9afuen7k 350 21 mucosal mucosal JJ cord-346964-9afuen7k 350 22 components component NNS cord-346964-9afuen7k 350 23 including include VBG cord-346964-9afuen7k 350 24 the the DT cord-346964-9afuen7k 350 25 enterocytes enterocyte NNS cord-346964-9afuen7k 350 26 and and CC cord-346964-9afuen7k 350 27 the the DT cord-346964-9afuen7k 350 28 immune immune JJ cord-346964-9afuen7k 350 29 modulators modulator NNS cord-346964-9afuen7k 350 30 and and CC cord-346964-9afuen7k 350 31 effector effector NN cord-346964-9afuen7k 350 32 cells cell NNS cord-346964-9afuen7k 350 33 in in IN cord-346964-9afuen7k 350 34 the the DT cord-346964-9afuen7k 350 35 lamina lamina JJ cord-346964-9afuen7k 350 36 propria propria NN cord-346964-9afuen7k 350 37 . . . cord-346964-9afuen7k 351 1 This this DT cord-346964-9afuen7k 351 2 interaction interaction NN cord-346964-9afuen7k 351 3 requires require VBZ cord-346964-9afuen7k 351 4 an an DT cord-346964-9afuen7k 351 5 intact intact JJ cord-346964-9afuen7k 351 6 mucosa mucosa JJ cord-346964-9afuen7k 351 7 with with IN cord-346964-9afuen7k 351 8 intact intact JJ cord-346964-9afuen7k 351 9 enterocytes enterocyte NNS cord-346964-9afuen7k 351 10 as as RB cord-346964-9afuen7k 351 11 well well RB cord-346964-9afuen7k 351 12 as as IN cord-346964-9afuen7k 351 13 an an DT cord-346964-9afuen7k 351 14 intact intact JJ cord-346964-9afuen7k 351 15 innate innate JJ cord-346964-9afuen7k 351 16 and and CC cord-346964-9afuen7k 351 17 adaptive adaptive JJ cord-346964-9afuen7k 351 18 intestinal intestinal JJ cord-346964-9afuen7k 351 19 immune immune JJ cord-346964-9afuen7k 351 20 system system NN cord-346964-9afuen7k 351 21 . . . cord-346964-9afuen7k 352 1 The the DT cord-346964-9afuen7k 352 2 way way NN cord-346964-9afuen7k 352 3 that that WDT cord-346964-9afuen7k 352 4 intestinal intestinal JJ cord-346964-9afuen7k 352 5 immune immune JJ cord-346964-9afuen7k 352 6 system system NN cord-346964-9afuen7k 352 7 recognizes recognize VBZ cord-346964-9afuen7k 352 8 pathogens pathogen NNS cord-346964-9afuen7k 352 9 from from IN cord-346964-9afuen7k 352 10 nutrients nutrient NNS cord-346964-9afuen7k 352 11 and and CC cord-346964-9afuen7k 352 12 microflora microflora NN cord-346964-9afuen7k 352 13 residents resident NNS cord-346964-9afuen7k 352 14 is be VBZ cord-346964-9afuen7k 352 15 via via IN cord-346964-9afuen7k 352 16 the the DT cord-346964-9afuen7k 352 17 recognition recognition NN cord-346964-9afuen7k 352 18 of of IN cord-346964-9afuen7k 352 19 pathogen pathogen NN cord-346964-9afuen7k 352 20 - - HYPH cord-346964-9afuen7k 352 21 associated associate VBN cord-346964-9afuen7k 352 22 molecular molecular JJ cord-346964-9afuen7k 352 23 patterns pattern NNS cord-346964-9afuen7k 352 24 ( ( -LRB- cord-346964-9afuen7k 352 25 PAMPs pamp NNS cord-346964-9afuen7k 352 26 ) ) -RRB- cord-346964-9afuen7k 352 27 . . . cord-346964-9afuen7k 353 1 These these DT cord-346964-9afuen7k 353 2 pattern pattern NN cord-346964-9afuen7k 353 3 recognition recognition NN cord-346964-9afuen7k 353 4 receptors receptor NNS cord-346964-9afuen7k 353 5 include include VBP cord-346964-9afuen7k 353 6 Toll toll NN cord-346964-9afuen7k 353 7 - - HYPH cord-346964-9afuen7k 353 8 like like JJ cord-346964-9afuen7k 353 9 receptors receptor NNS cord-346964-9afuen7k 353 10 and and CC cord-346964-9afuen7k 353 11 NOD nod NN cord-346964-9afuen7k 353 12 - - HYPH cord-346964-9afuen7k 353 13 like like JJ cord-346964-9afuen7k 353 14 receptors receptor NNS cord-346964-9afuen7k 353 15 that that WDT cord-346964-9afuen7k 353 16 sense sense VBP cord-346964-9afuen7k 353 17 extracellular extracellular JJ cord-346964-9afuen7k 353 18 and and CC cord-346964-9afuen7k 353 19 intracellular intracellular JJ cord-346964-9afuen7k 353 20 PAMPs pamp NNS cord-346964-9afuen7k 353 21 , , , cord-346964-9afuen7k 353 22 respectively respectively RB cord-346964-9afuen7k 353 23 . . . cord-346964-9afuen7k 354 1 They -PRON- PRP cord-346964-9afuen7k 354 2 are be VBP cord-346964-9afuen7k 354 3 specifically specifically RB cord-346964-9afuen7k 354 4 expressed express VBN cord-346964-9afuen7k 354 5 in in IN cord-346964-9afuen7k 354 6 response response NN cord-346964-9afuen7k 354 7 to to IN cord-346964-9afuen7k 354 8 certain certain JJ cord-346964-9afuen7k 354 9 microbial microbial JJ cord-346964-9afuen7k 354 10 stimuli stimulus NNS cord-346964-9afuen7k 354 11 , , , cord-346964-9afuen7k 354 12 especially especially RB cord-346964-9afuen7k 354 13 to to IN cord-346964-9afuen7k 354 14 invasive invasive JJ cord-346964-9afuen7k 354 15 microorganisms microorganism NNS cord-346964-9afuen7k 354 16 . . . cord-346964-9afuen7k 355 1 The the DT cord-346964-9afuen7k 355 2 immune immune JJ cord-346964-9afuen7k 355 3 effectors effector NNS cord-346964-9afuen7k 355 4 or or CC cord-346964-9afuen7k 355 5 modulators modulator NNS cord-346964-9afuen7k 355 6 , , , cord-346964-9afuen7k 355 7 on on IN cord-346964-9afuen7k 355 8 the the DT cord-346964-9afuen7k 355 9 other other JJ cord-346964-9afuen7k 355 10 hand hand NN cord-346964-9afuen7k 355 11 , , , cord-346964-9afuen7k 355 12 are be VBP cord-346964-9afuen7k 355 13 products product NNS cord-346964-9afuen7k 355 14 of of IN cord-346964-9afuen7k 355 15 distinct distinct JJ cord-346964-9afuen7k 355 16 genes gene NNS cord-346964-9afuen7k 355 17 , , , cord-346964-9afuen7k 355 18 which which WDT cord-346964-9afuen7k 355 19 may may MD cord-346964-9afuen7k 355 20 be be VB cord-346964-9afuen7k 355 21 either either CC cord-346964-9afuen7k 355 22 constitutively constitutively RB cord-346964-9afuen7k 355 23 expressed express VBN cord-346964-9afuen7k 355 24 ( ( -LRB- cord-346964-9afuen7k 355 25 i.e. i.e. FW cord-346964-9afuen7k 355 26 , , , cord-346964-9afuen7k 355 27 alpha alpha NN cord-346964-9afuen7k 355 28 defensins defensin NNS cord-346964-9afuen7k 355 29 ) ) -RRB- cord-346964-9afuen7k 355 30 or or CC cord-346964-9afuen7k 355 31 inducible inducible JJ cord-346964-9afuen7k 355 32 ( ( -LRB- cord-346964-9afuen7k 355 33 i.e. i.e. FW cord-346964-9afuen7k 355 34 , , , cord-346964-9afuen7k 355 35 beta beta NN cord-346964-9afuen7k 355 36 defensins defensin NNS cord-346964-9afuen7k 355 37 ) ) -RRB- cord-346964-9afuen7k 355 38 molecules molecule NNS cord-346964-9afuen7k 355 39 by by IN cord-346964-9afuen7k 355 40 infectious infectious JJ cord-346964-9afuen7k 355 41 stimuli stimulus NNS cord-346964-9afuen7k 355 42 . . . cord-346964-9afuen7k 356 1 Bacterial bacterial JJ cord-346964-9afuen7k 356 2 enteropathogens enteropathogen NNS cord-346964-9afuen7k 356 3 have have VBP cord-346964-9afuen7k 356 4 a a DT cord-346964-9afuen7k 356 5 variety variety NN cord-346964-9afuen7k 356 6 of of IN cord-346964-9afuen7k 356 7 virulence virulence NN cord-346964-9afuen7k 356 8 properties property NNS cord-346964-9afuen7k 356 9 that that WDT cord-346964-9afuen7k 356 10 determine determine VBP cord-346964-9afuen7k 356 11 the the DT cord-346964-9afuen7k 356 12 pattern pattern NN cord-346964-9afuen7k 356 13 of of IN cord-346964-9afuen7k 356 14 interaction interaction NN cord-346964-9afuen7k 356 15 with with IN cord-346964-9afuen7k 356 16 the the DT cord-346964-9afuen7k 356 17 intestinal intestinal JJ cord-346964-9afuen7k 356 18 mucosa mucosa NN cord-346964-9afuen7k 356 19 and and CC cord-346964-9afuen7k 356 20 the the DT cord-346964-9afuen7k 356 21 clinical clinical JJ cord-346964-9afuen7k 356 22 presentation presentation NN cord-346964-9afuen7k 356 23 . . . cord-346964-9afuen7k 357 1 Bacterial bacterial JJ cord-346964-9afuen7k 357 2 adherence adherence NN cord-346964-9afuen7k 357 3 and and CC cord-346964-9afuen7k 357 4 bacterial bacterial JJ cord-346964-9afuen7k 357 5 translocation translocation NN cord-346964-9afuen7k 357 6 are be VBP cord-346964-9afuen7k 357 7 the the DT cord-346964-9afuen7k 357 8 two two CD cord-346964-9afuen7k 357 9 major major JJ cord-346964-9afuen7k 357 10 mechanisms mechanism NNS cord-346964-9afuen7k 357 11 by by IN cord-346964-9afuen7k 357 12 which which WDT cord-346964-9afuen7k 357 13 intestinal intestinal JJ cord-346964-9afuen7k 357 14 damage damage NN cord-346964-9afuen7k 357 15 occurs occur VBZ cord-346964-9afuen7k 357 16 . . . cord-346964-9afuen7k 358 1 Enterocyte Enterocyte NNP cord-346964-9afuen7k 358 2 adherence adherence NN cord-346964-9afuen7k 358 3 results result NNS cord-346964-9afuen7k 358 4 from from IN cord-346964-9afuen7k 358 5 interaction interaction NN cord-346964-9afuen7k 358 6 between between IN cord-346964-9afuen7k 358 7 bacteria bacteria NNS cord-346964-9afuen7k 358 8 and and CC cord-346964-9afuen7k 358 9 its -PRON- PRP$ cord-346964-9afuen7k 358 10 receptor receptor NN cord-346964-9afuen7k 358 11 on on IN cord-346964-9afuen7k 358 12 the the DT cord-346964-9afuen7k 358 13 epithelial epithelial JJ cord-346964-9afuen7k 358 14 cell cell NN cord-346964-9afuen7k 358 15 surface surface NN cord-346964-9afuen7k 358 16 . . . cord-346964-9afuen7k 359 1 Bacterial bacterial JJ cord-346964-9afuen7k 359 2 translocation translocation NN cord-346964-9afuen7k 359 3 , , , cord-346964-9afuen7k 359 4 on on IN cord-346964-9afuen7k 359 5 the the DT cord-346964-9afuen7k 359 6 other other JJ cord-346964-9afuen7k 359 7 hand hand NN cord-346964-9afuen7k 359 8 , , , cord-346964-9afuen7k 359 9 refers refer VBZ cord-346964-9afuen7k 359 10 to to IN cord-346964-9afuen7k 359 11 the the DT cord-346964-9afuen7k 359 12 transportation transportation NN cord-346964-9afuen7k 359 13 of of IN cord-346964-9afuen7k 359 14 bacteria bacteria NNS cord-346964-9afuen7k 359 15 from from IN cord-346964-9afuen7k 359 16 the the DT cord-346964-9afuen7k 359 17 lumen lumen NN cord-346964-9afuen7k 359 18 through through IN cord-346964-9afuen7k 359 19 the the DT cord-346964-9afuen7k 359 20 mucosa mucosa NN cord-346964-9afuen7k 359 21 to to IN cord-346964-9afuen7k 359 22 distant distant JJ cord-346964-9afuen7k 359 23 sites site NNS cord-346964-9afuen7k 359 24 such such JJ cord-346964-9afuen7k 359 25 as as IN cord-346964-9afuen7k 359 26 the the DT cord-346964-9afuen7k 359 27 mesenteric mesenteric JJ cord-346964-9afuen7k 359 28 lymph lymph NN cord-346964-9afuen7k 359 29 nodes node NNS cord-346964-9afuen7k 359 30 , , , cord-346964-9afuen7k 359 31 spleen spleen NNS cord-346964-9afuen7k 359 32 , , , cord-346964-9afuen7k 359 33 and and CC cord-346964-9afuen7k 359 34 liver liver NN cord-346964-9afuen7k 359 35 . . . cord-346964-9afuen7k 360 1 Bacterial bacterial JJ cord-346964-9afuen7k 360 2 overgrowth overgrowth NN cord-346964-9afuen7k 360 3 , , , cord-346964-9afuen7k 360 4 impaired impair VBN cord-346964-9afuen7k 360 5 host host NN cord-346964-9afuen7k 360 6 defenses defense NNS cord-346964-9afuen7k 360 7 , , , cord-346964-9afuen7k 360 8 and and CC cord-346964-9afuen7k 360 9 disruption disruption NN cord-346964-9afuen7k 360 10 of of IN cord-346964-9afuen7k 360 11 mucosal mucosal JJ cord-346964-9afuen7k 360 12 barrier barrier NN cord-346964-9afuen7k 360 13 are be VBP cord-346964-9afuen7k 360 14 the the DT cord-346964-9afuen7k 360 15 main main JJ cord-346964-9afuen7k 360 16 causes cause NNS cord-346964-9afuen7k 360 17 of of IN cord-346964-9afuen7k 360 18 bacterial bacterial JJ cord-346964-9afuen7k 360 19 translocation translocation NN cord-346964-9afuen7k 360 20 ( ( -LRB- cord-346964-9afuen7k 360 21 Figure figure NN cord-346964-9afuen7k 360 22 19 19 CD cord-346964-9afuen7k 360 23 ) ) -RRB- cord-346964-9afuen7k 360 24 . . . cord-346964-9afuen7k 361 1 Though though IN cord-346964-9afuen7k 361 2 numerous numerous JJ cord-346964-9afuen7k 361 3 bacteria bacteria NNS cord-346964-9afuen7k 361 4 may may MD cord-346964-9afuen7k 361 5 cause cause VB cord-346964-9afuen7k 361 6 small small JJ cord-346964-9afuen7k 361 7 intestinal intestinal JJ cord-346964-9afuen7k 361 8 infection infection NN cord-346964-9afuen7k 361 9 , , , cord-346964-9afuen7k 361 10 they -PRON- PRP cord-346964-9afuen7k 361 11 usually usually RB cord-346964-9afuen7k 361 12 involve involve VBP cord-346964-9afuen7k 361 13 the the DT cord-346964-9afuen7k 361 14 colonic colonic JJ cord-346964-9afuen7k 361 15 mucosa mucosa NN cord-346964-9afuen7k 361 16 as as RB cord-346964-9afuen7k 361 17 well well RB cord-346964-9afuen7k 361 18 , , , cord-346964-9afuen7k 361 19 in in IN cord-346964-9afuen7k 361 20 the the DT cord-346964-9afuen7k 361 21 form form NN cord-346964-9afuen7k 361 22 of of IN cord-346964-9afuen7k 361 23 enterocolitis enterocolitis NN cord-346964-9afuen7k 361 24 . . . cord-346964-9afuen7k 362 1 Therefore therefore RB cord-346964-9afuen7k 362 2 , , , cord-346964-9afuen7k 362 3 those those DT cord-346964-9afuen7k 362 4 that that WDT cord-346964-9afuen7k 362 5 mainly mainly RB cord-346964-9afuen7k 362 6 affect affect VBP cord-346964-9afuen7k 362 7 the the DT cord-346964-9afuen7k 362 8 small small JJ cord-346964-9afuen7k 362 9 intestine intestine NN cord-346964-9afuen7k 362 10 will will MD cord-346964-9afuen7k 362 11 be be VB cord-346964-9afuen7k 362 12 discussed discuss VBN cord-346964-9afuen7k 362 13 here here RB cord-346964-9afuen7k 362 14 . . . cord-346964-9afuen7k 363 1 All all DT cord-346964-9afuen7k 363 2 causes cause NNS cord-346964-9afuen7k 363 3 of of IN cord-346964-9afuen7k 363 4 bacterial bacterial JJ cord-346964-9afuen7k 363 5 overgrowth overgrowth NN cord-346964-9afuen7k 363 6 including include VBG cord-346964-9afuen7k 363 7 motor motor NN cord-346964-9afuen7k 363 8 / / SYM cord-346964-9afuen7k 363 9 neural neural JJ cord-346964-9afuen7k 363 10 disorders disorder NNS cord-346964-9afuen7k 363 11 such such JJ cord-346964-9afuen7k 363 12 as as IN cord-346964-9afuen7k 363 13 diabetes diabetes NN cord-346964-9afuen7k 363 14 and and CC cord-346964-9afuen7k 363 15 scleroderma scleroderma NN cord-346964-9afuen7k 363 16 , , , cord-346964-9afuen7k 363 17 diverticula diverticula NN cord-346964-9afuen7k 363 18 , , , cord-346964-9afuen7k 363 19 and and CC cord-346964-9afuen7k 363 20 surgical surgical JJ cord-346964-9afuen7k 363 21 anastomoses anastomosis NNS cord-346964-9afuen7k 363 22 are be VBP cord-346964-9afuen7k 363 23 related relate VBN cord-346964-9afuen7k 363 24 to to IN cord-346964-9afuen7k 363 25 stasis stasis NN cord-346964-9afuen7k 363 26 . . . cord-346964-9afuen7k 364 1 Bacterial bacterial JJ cord-346964-9afuen7k 364 2 overgrowth overgrowth NN cord-346964-9afuen7k 364 3 syndrome syndrome NN cord-346964-9afuen7k 364 4 is be VBZ cord-346964-9afuen7k 364 5 more more RBR cord-346964-9afuen7k 364 6 prevalent prevalent JJ cord-346964-9afuen7k 364 7 in in IN cord-346964-9afuen7k 364 8 elderly elderly JJ cord-346964-9afuen7k 364 9 populations population NNS cord-346964-9afuen7k 364 10 because because IN cord-346964-9afuen7k 364 11 of of IN cord-346964-9afuen7k 364 12 diminished diminished JJ cord-346964-9afuen7k 364 13 gastric gastric JJ cord-346964-9afuen7k 364 14 acid acid NN cord-346964-9afuen7k 364 15 secretion secretion NN cord-346964-9afuen7k 364 16 and and CC cord-346964-9afuen7k 364 17 consumption consumption NN cord-346964-9afuen7k 364 18 of of IN cord-346964-9afuen7k 364 19 a a DT cord-346964-9afuen7k 364 20 large large JJ cord-346964-9afuen7k 364 21 number number NN cord-346964-9afuen7k 364 22 of of IN cord-346964-9afuen7k 364 23 medications medication NNS cord-346964-9afuen7k 364 24 that that WDT cord-346964-9afuen7k 364 25 can can MD cord-346964-9afuen7k 364 26 cause cause VB cord-346964-9afuen7k 364 27 hypomotility hypomotility NN cord-346964-9afuen7k 364 28 . . . cord-346964-9afuen7k 365 1 In in IN cord-346964-9afuen7k 365 2 addition addition NN cord-346964-9afuen7k 365 3 , , , cord-346964-9afuen7k 365 4 many many JJ cord-346964-9afuen7k 365 5 patients patient NNS cord-346964-9afuen7k 365 6 with with IN cord-346964-9afuen7k 365 7 irritable irritable JJ cord-346964-9afuen7k 365 8 bowel bowel NN cord-346964-9afuen7k 365 9 syndrome syndrome NN cord-346964-9afuen7k 365 10 may may MD cord-346964-9afuen7k 365 11 suffer suffer VB cord-346964-9afuen7k 365 12 from from IN cord-346964-9afuen7k 365 13 this this DT cord-346964-9afuen7k 365 14 condition condition NN cord-346964-9afuen7k 365 15 . . . cord-346964-9afuen7k 366 1 Normally normally RB cord-346964-9afuen7k 366 2 , , , cord-346964-9afuen7k 366 3 small small JJ cord-346964-9afuen7k 366 4 intestinal intestinal JJ cord-346964-9afuen7k 366 5 lumen lumen NN cord-346964-9afuen7k 366 6 is be VBZ cord-346964-9afuen7k 366 7 colonized colonize VBN cord-346964-9afuen7k 366 8 by by IN cord-346964-9afuen7k 366 9 facultative facultative JJ cord-346964-9afuen7k 366 10 anaerobe anaerobe NN cord-346964-9afuen7k 366 11 or or CC cord-346964-9afuen7k 366 12 obligate obligate VB cord-346964-9afuen7k 366 13 bacteria bacteria NNS cord-346964-9afuen7k 366 14 , , , cord-346964-9afuen7k 366 15 particularly particularly RB cord-346964-9afuen7k 366 16 bacteroides bacteroides NNP cord-346964-9afuen7k 366 17 species specie NNS cord-346964-9afuen7k 366 18 , , , cord-346964-9afuen7k 366 19 which which WDT cord-346964-9afuen7k 366 20 are be VBP cord-346964-9afuen7k 366 21 most most RBS cord-346964-9afuen7k 366 22 abundant abundant JJ cord-346964-9afuen7k 366 23 in in IN cord-346964-9afuen7k 366 24 the the DT cord-346964-9afuen7k 366 25 distal distal JJ cord-346964-9afuen7k 366 26 ileum ileum NN cord-346964-9afuen7k 366 27 . . . cord-346964-9afuen7k 367 1 Any any DT cord-346964-9afuen7k 367 2 disbalance disbalance NN cord-346964-9afuen7k 367 3 of of IN cord-346964-9afuen7k 367 4 this this DT cord-346964-9afuen7k 367 5 complex complex JJ cord-346964-9afuen7k 367 6 intestinal intestinal JJ cord-346964-9afuen7k 367 7 microbiome microbiome NN cord-346964-9afuen7k 367 8 , , , cord-346964-9afuen7k 367 9 both both CC cord-346964-9afuen7k 367 10 qualitative qualitative JJ cord-346964-9afuen7k 367 11 and and CC cord-346964-9afuen7k 367 12 quantitative quantitative JJ cord-346964-9afuen7k 367 13 , , , cord-346964-9afuen7k 367 14 might may MD cord-346964-9afuen7k 367 15 have have VB cord-346964-9afuen7k 367 16 serious serious JJ cord-346964-9afuen7k 367 17 health health NN cord-346964-9afuen7k 367 18 consequences consequence NNS cord-346964-9afuen7k 367 19 resulting result VBG cord-346964-9afuen7k 367 20 in in IN cord-346964-9afuen7k 367 21 SIBO SIBO NNP cord-346964-9afuen7k 367 22 . . . cord-346964-9afuen7k 368 1 The the DT cord-346964-9afuen7k 368 2 diagnosis diagnosis NN cord-346964-9afuen7k 368 3 of of IN cord-346964-9afuen7k 368 4 bacterial bacterial JJ cord-346964-9afuen7k 368 5 overgrowth overgrowth NN cord-346964-9afuen7k 368 6 relies rely VBZ cord-346964-9afuen7k 368 7 on on IN cord-346964-9afuen7k 368 8 the the DT cord-346964-9afuen7k 368 9 presence presence NN cord-346964-9afuen7k 368 10 of of IN cord-346964-9afuen7k 368 11 increased increase VBN cord-346964-9afuen7k 368 12 intestinal intestinal JJ cord-346964-9afuen7k 368 13 volume volume NN cord-346964-9afuen7k 368 14 and and CC cord-346964-9afuen7k 368 15 bacterial bacterial JJ cord-346964-9afuen7k 368 16 concentrations concentration NNS cord-346964-9afuen7k 368 17 , , , cord-346964-9afuen7k 368 18 hydrogen hydrogen NN cord-346964-9afuen7k 368 19 breath breath NN cord-346964-9afuen7k 368 20 tests test NNS cord-346964-9afuen7k 368 21 , , , cord-346964-9afuen7k 368 22 and and CC cord-346964-9afuen7k 368 23 response response NN cord-346964-9afuen7k 368 24 to to IN cord-346964-9afuen7k 368 25 antibiotics antibiotic NNS cord-346964-9afuen7k 368 26 . . . cord-346964-9afuen7k 369 1 Small small JJ cord-346964-9afuen7k 369 2 bowel bowel NN cord-346964-9afuen7k 369 3 aspirate aspirate NN cord-346964-9afuen7k 369 4 and and CC cord-346964-9afuen7k 369 5 quantitative quantitative JJ cord-346964-9afuen7k 369 6 cultures culture NNS cord-346964-9afuen7k 369 7 with with IN cord-346964-9afuen7k 369 8 more more JJR cord-346964-9afuen7k 369 9 than than IN cord-346964-9afuen7k 369 10 10 10 CD cord-346964-9afuen7k 369 11 5 5 CD cord-346964-9afuen7k 369 12 CFU CFU NNP cord-346964-9afuen7k 369 13 ml ml NNP cord-346964-9afuen7k 369 14 À1 À1 NNP cord-346964-9afuen7k 369 15 considered consider VBD cord-346964-9afuen7k 369 16 the the DT cord-346964-9afuen7k 369 17 cutoff cutoff NN cord-346964-9afuen7k 369 18 are be VBP cord-346964-9afuen7k 369 19 the the DT cord-346964-9afuen7k 369 20 diagnostic diagnostic JJ cord-346964-9afuen7k 369 21 procedures procedure NNS cord-346964-9afuen7k 369 22 . . . cord-346964-9afuen7k 370 1 The the DT cord-346964-9afuen7k 370 2 resultant resultant JJ cord-346964-9afuen7k 370 3 picture picture NN cord-346964-9afuen7k 370 4 involves involve VBZ cord-346964-9afuen7k 370 5 deconjugation deconjugation NN cord-346964-9afuen7k 370 6 of of IN cord-346964-9afuen7k 370 7 bile bile NN cord-346964-9afuen7k 370 8 acids acid NNS cord-346964-9afuen7k 370 9 by by IN cord-346964-9afuen7k 370 10 bacterial bacterial JJ cord-346964-9afuen7k 370 11 enzymes enzyme NNS cord-346964-9afuen7k 370 12 causing cause VBG cord-346964-9afuen7k 370 13 loss loss NN cord-346964-9afuen7k 370 14 of of IN cord-346964-9afuen7k 370 15 deconjugated deconjugate VBN cord-346964-9afuen7k 370 16 bile bile NN cord-346964-9afuen7k 370 17 acids acid NNS cord-346964-9afuen7k 370 18 in in IN cord-346964-9afuen7k 370 19 stool stool NN cord-346964-9afuen7k 370 20 and and CC cord-346964-9afuen7k 370 21 decreased decrease VBD cord-346964-9afuen7k 370 22 bile bile NN cord-346964-9afuen7k 370 23 acid acid NN cord-346964-9afuen7k 370 24 pool pool NN cord-346964-9afuen7k 370 25 that that WDT cord-346964-9afuen7k 370 26 is be VBZ cord-346964-9afuen7k 370 27 not not RB cord-346964-9afuen7k 370 28 enough enough JJ cord-346964-9afuen7k 370 29 for for IN cord-346964-9afuen7k 370 30 lipid lipid NN cord-346964-9afuen7k 370 31 digestion digestion NN cord-346964-9afuen7k 370 32 / / SYM cord-346964-9afuen7k 370 33 absorption absorption NN cord-346964-9afuen7k 370 34 . . . cord-346964-9afuen7k 371 1 Moreover moreover RB cord-346964-9afuen7k 371 2 , , , cord-346964-9afuen7k 371 3 intraluminal intraluminal JJ cord-346964-9afuen7k 371 4 consumption consumption NN cord-346964-9afuen7k 371 5 of of IN cord-346964-9afuen7k 371 6 nutrients nutrient NNS cord-346964-9afuen7k 371 7 such such JJ cord-346964-9afuen7k 371 8 as as IN cord-346964-9afuen7k 371 9 carbohydrates carbohydrate NNS cord-346964-9afuen7k 371 10 and and CC cord-346964-9afuen7k 371 11 amino amino JJ cord-346964-9afuen7k 371 12 acids acid NNS cord-346964-9afuen7k 371 13 , , , cord-346964-9afuen7k 371 14 vitamin vitamin NN cord-346964-9afuen7k 371 15 B12 b12 NN cord-346964-9afuen7k 371 16 , , , cord-346964-9afuen7k 371 17 and and CC cord-346964-9afuen7k 371 18 iron iron NN cord-346964-9afuen7k 371 19 by by IN cord-346964-9afuen7k 371 20 bacteria bacteria NNS cord-346964-9afuen7k 371 21 via via IN cord-346964-9afuen7k 371 22 competition competition NN cord-346964-9afuen7k 371 23 and and CC cord-346964-9afuen7k 371 24 damage damage NN cord-346964-9afuen7k 371 25 to to IN cord-346964-9afuen7k 371 26 small small JJ cord-346964-9afuen7k 371 27 bowel bowel NN cord-346964-9afuen7k 371 28 enterocytes enterocyte NNS cord-346964-9afuen7k 371 29 by by IN cord-346964-9afuen7k 371 30 bacteria bacteria NNS cord-346964-9afuen7k 371 31 causes cause VBZ cord-346964-9afuen7k 371 32 a a DT cord-346964-9afuen7k 371 33 sprue sprue NN cord-346964-9afuen7k 371 34 - - HYPH cord-346964-9afuen7k 371 35 like like JJ cord-346964-9afuen7k 371 36 histological histological JJ cord-346964-9afuen7k 371 37 and and CC cord-346964-9afuen7k 371 38 clinical clinical JJ cord-346964-9afuen7k 371 39 picture picture NN cord-346964-9afuen7k 371 40 . . . cord-346964-9afuen7k 372 1 Proposed propose VBN cord-346964-9afuen7k 372 2 mechanisms mechanism NNS cord-346964-9afuen7k 372 3 for for IN cord-346964-9afuen7k 372 4 bacterial bacterial JJ cord-346964-9afuen7k 372 5 overgrowth overgrowth NN cord-346964-9afuen7k 372 6 are be VBP cord-346964-9afuen7k 372 7 presented present VBN cord-346964-9afuen7k 372 8 in in IN cord-346964-9afuen7k 372 9 Table Table NNP cord-346964-9afuen7k 372 10 8 8 CD cord-346964-9afuen7k 372 11 . . . cord-346964-9afuen7k 373 1 The the DT cord-346964-9afuen7k 373 2 mucosal mucosal JJ cord-346964-9afuen7k 373 3 biopsy biopsy NN cord-346964-9afuen7k 373 4 may may MD cord-346964-9afuen7k 373 5 be be VB cord-346964-9afuen7k 373 6 normal normal JJ cord-346964-9afuen7k 373 7 or or CC cord-346964-9afuen7k 373 8 histopathologic histopathologic JJ cord-346964-9afuen7k 373 9 picture picture NN cord-346964-9afuen7k 373 10 may may MD cord-346964-9afuen7k 373 11 vary vary VB cord-346964-9afuen7k 373 12 between between IN cord-346964-9afuen7k 373 13 mild mild JJ cord-346964-9afuen7k 373 14 to to IN cord-346964-9afuen7k 373 15 moderate moderate JJ cord-346964-9afuen7k 373 16 villous villous NN cord-346964-9afuen7k 373 17 shortening shorten VBG cord-346964-9afuen7k 373 18 and and CC cord-346964-9afuen7k 373 19 blunting blunt VBG cord-346964-9afuen7k 373 20 with with IN cord-346964-9afuen7k 373 21 increased increase VBN cord-346964-9afuen7k 373 22 chronic chronic JJ cord-346964-9afuen7k 373 23 inflammatory inflammatory JJ cord-346964-9afuen7k 373 24 cells cell NNS cord-346964-9afuen7k 373 25 in in IN cord-346964-9afuen7k 373 26 the the DT cord-346964-9afuen7k 373 27 lamina lamina JJ cord-346964-9afuen7k 373 28 propria propria NNP cord-346964-9afuen7k 373 29 and and CC cord-346964-9afuen7k 373 30 IELs iel NNS cord-346964-9afuen7k 373 31 and/or and/or CC cord-346964-9afuen7k 373 32 neutrophils neutrophil NNS cord-346964-9afuen7k 373 33 . . . cord-346964-9afuen7k 374 1 As as IN cord-346964-9afuen7k 374 2 these these DT cord-346964-9afuen7k 374 3 features feature NNS cord-346964-9afuen7k 374 4 are be VBP cord-346964-9afuen7k 374 5 usually usually RB cord-346964-9afuen7k 374 6 patchy patchy JJ cord-346964-9afuen7k 374 7 in in IN cord-346964-9afuen7k 374 8 nature nature NN cord-346964-9afuen7k 374 9 , , , cord-346964-9afuen7k 374 10 multiple multiple JJ cord-346964-9afuen7k 374 11 biopsies biopsy NNS cord-346964-9afuen7k 374 12 should should MD cord-346964-9afuen7k 374 13 be be VB cord-346964-9afuen7k 374 14 taken take VBN cord-346964-9afuen7k 374 15 . . . cord-346964-9afuen7k 375 1 The the DT cord-346964-9afuen7k 375 2 diagnosis diagnosis NN cord-346964-9afuen7k 375 3 is be VBZ cord-346964-9afuen7k 375 4 difficult difficult JJ cord-346964-9afuen7k 375 5 for for IN cord-346964-9afuen7k 375 6 the the DT cord-346964-9afuen7k 375 7 pathologist pathologist NN cord-346964-9afuen7k 375 8 without without IN cord-346964-9afuen7k 375 9 clinical clinical JJ cord-346964-9afuen7k 375 10 correlation correlation NN cord-346964-9afuen7k 375 11 . . . cord-346964-9afuen7k 376 1 Whipple Whipple NNP cord-346964-9afuen7k 376 2 's 's POS cord-346964-9afuen7k 376 3 disease disease NN cord-346964-9afuen7k 376 4 WD WD NNP cord-346964-9afuen7k 376 5 is be VBZ cord-346964-9afuen7k 376 6 a a DT cord-346964-9afuen7k 376 7 rare rare JJ cord-346964-9afuen7k 376 8 , , , cord-346964-9afuen7k 376 9 relapsing relapse VBG cord-346964-9afuen7k 376 10 chronic chronic JJ cord-346964-9afuen7k 376 11 , , , cord-346964-9afuen7k 376 12 and and CC cord-346964-9afuen7k 376 13 systemic systemic JJ cord-346964-9afuen7k 376 14 bacterial bacterial JJ cord-346964-9afuen7k 376 15 infection infection NN cord-346964-9afuen7k 376 16 caused cause VBN cord-346964-9afuen7k 376 17 by by IN cord-346964-9afuen7k 376 18 an an DT cord-346964-9afuen7k 376 19 actinomycete actinomycete NN cord-346964-9afuen7k 376 20 , , , cord-346964-9afuen7k 376 21 Tropheryma Tropheryma NNP cord-346964-9afuen7k 376 22 whipplei whipplei NNP cord-346964-9afuen7k 376 23 . . . cord-346964-9afuen7k 377 1 There there EX cord-346964-9afuen7k 377 2 is be VBZ cord-346964-9afuen7k 377 3 evidence evidence NN cord-346964-9afuen7k 377 4 of of IN cord-346964-9afuen7k 377 5 a a DT cord-346964-9afuen7k 377 6 host host NN cord-346964-9afuen7k 377 7 - - HYPH cord-346964-9afuen7k 377 8 related relate VBN cord-346964-9afuen7k 377 9 and and CC cord-346964-9afuen7k 377 10 possibly possibly RB cord-346964-9afuen7k 377 11 genetically genetically RB cord-346964-9afuen7k 377 12 determined determine VBN cord-346964-9afuen7k 377 13 increased increase VBN cord-346964-9afuen7k 377 14 susceptibility susceptibility NN cord-346964-9afuen7k 377 15 to to IN cord-346964-9afuen7k 377 16 Whipple Whipple NNP cord-346964-9afuen7k 377 17 's 's POS cord-346964-9afuen7k 377 18 disease disease NN cord-346964-9afuen7k 377 19 related relate VBN cord-346964-9afuen7k 377 20 to to IN cord-346964-9afuen7k 377 21 innate innate JJ cord-346964-9afuen7k 377 22 Bacterial bacterial JJ cord-346964-9afuen7k 377 23 translocation translocation NN cord-346964-9afuen7k 377 24 Figure figure NN cord-346964-9afuen7k 377 25 19 19 CD cord-346964-9afuen7k 377 26 Mechanisms mechanism NNS cord-346964-9afuen7k 377 27 of of IN cord-346964-9afuen7k 377 28 intestinal intestinal JJ cord-346964-9afuen7k 377 29 damage damage NN cord-346964-9afuen7k 377 30 in in IN cord-346964-9afuen7k 377 31 bacterial bacterial JJ cord-346964-9afuen7k 377 32 infections infection NNS cord-346964-9afuen7k 377 33 . . . cord-346964-9afuen7k 378 1 Bacterial bacterial JJ cord-346964-9afuen7k 378 2 adhesion adhesion NN cord-346964-9afuen7k 378 3 results result NNS cord-346964-9afuen7k 378 4 from from IN cord-346964-9afuen7k 378 5 the the DT cord-346964-9afuen7k 378 6 interaction interaction NN cord-346964-9afuen7k 378 7 between between IN cord-346964-9afuen7k 378 8 bacteria bacteria NNS cord-346964-9afuen7k 378 9 and and CC cord-346964-9afuen7k 378 10 its -PRON- PRP$ cord-346964-9afuen7k 378 11 receptor receptor NN cord-346964-9afuen7k 378 12 on on IN cord-346964-9afuen7k 378 13 the the DT cord-346964-9afuen7k 378 14 epithelial epithelial JJ cord-346964-9afuen7k 378 15 cell cell NN cord-346964-9afuen7k 378 16 surface surface NN cord-346964-9afuen7k 378 17 , , , cord-346964-9afuen7k 378 18 whereas whereas IN cord-346964-9afuen7k 378 19 bacterial bacterial JJ cord-346964-9afuen7k 378 20 translocation translocation NN cord-346964-9afuen7k 378 21 refers refer VBZ cord-346964-9afuen7k 378 22 to to IN cord-346964-9afuen7k 378 23 the the DT cord-346964-9afuen7k 378 24 transportation transportation NN cord-346964-9afuen7k 378 25 of of IN cord-346964-9afuen7k 378 26 bacteria bacteria NNS cord-346964-9afuen7k 378 27 from from IN cord-346964-9afuen7k 378 28 the the DT cord-346964-9afuen7k 378 29 lumen lumen NN cord-346964-9afuen7k 378 30 through through IN cord-346964-9afuen7k 378 31 the the DT cord-346964-9afuen7k 378 32 mucosa mucosa NN cord-346964-9afuen7k 378 33 to to IN cord-346964-9afuen7k 378 34 distant distant JJ cord-346964-9afuen7k 378 35 sites site NNS cord-346964-9afuen7k 378 36 like like IN cord-346964-9afuen7k 378 37 mesenteric mesenteric JJ cord-346964-9afuen7k 378 38 lymph lymph NN cord-346964-9afuen7k 378 39 nodes node NNS cord-346964-9afuen7k 378 40 . . . cord-346964-9afuen7k 379 1 defects defect NNS cord-346964-9afuen7k 379 2 in in IN cord-346964-9afuen7k 379 3 T T NNP cord-346964-9afuen7k 379 4 cells cell NNS cord-346964-9afuen7k 379 5 and and CC cord-346964-9afuen7k 379 6 mononuclear mononuclear NN cord-346964-9afuen7k 379 7 cells cell NNS cord-346964-9afuen7k 379 8 . . . cord-346964-9afuen7k 380 1 Persistent persistent JJ cord-346964-9afuen7k 380 2 macrophage macrophage NN cord-346964-9afuen7k 380 3 dysfunction dysfunction NN cord-346964-9afuen7k 380 4 may may MD cord-346964-9afuen7k 380 5 predispose predispose VB cord-346964-9afuen7k 380 6 to to IN cord-346964-9afuen7k 380 7 the the DT cord-346964-9afuen7k 380 8 infection infection NN cord-346964-9afuen7k 380 9 since since IN cord-346964-9afuen7k 380 10 macrophages macrophage NNS cord-346964-9afuen7k 380 11 are be VBP cord-346964-9afuen7k 380 12 unable unable JJ cord-346964-9afuen7k 380 13 to to TO cord-346964-9afuen7k 380 14 degrade degrade VB cord-346964-9afuen7k 380 15 the the DT cord-346964-9afuen7k 380 16 phagocytosed phagocytosed JJ cord-346964-9afuen7k 380 17 bacteria bacteria NNS cord-346964-9afuen7k 380 18 . . . cord-346964-9afuen7k 381 1 Patients patient NNS cord-346964-9afuen7k 381 2 present present JJ cord-346964-9afuen7k 381 3 with with IN cord-346964-9afuen7k 381 4 malabsorptive malabsorptive JJ cord-346964-9afuen7k 381 5 diarrhea diarrhea NN cord-346964-9afuen7k 381 6 , , , cord-346964-9afuen7k 381 7 arthralgia arthralgia NNP cord-346964-9afuen7k 381 8 , , , cord-346964-9afuen7k 381 9 lymphadenopathy lymphadenopathy JJ cord-346964-9afuen7k 381 10 , , , cord-346964-9afuen7k 381 11 and and CC cord-346964-9afuen7k 381 12 cardiac cardiac JJ cord-346964-9afuen7k 381 13 and and CC cord-346964-9afuen7k 381 14 central central JJ cord-346964-9afuen7k 381 15 nervous nervous JJ cord-346964-9afuen7k 381 16 system system NN cord-346964-9afuen7k 381 17 symptoms symptom NNS cord-346964-9afuen7k 381 18 . . . cord-346964-9afuen7k 382 1 Malabsorption malabsorption NN cord-346964-9afuen7k 382 2 in in IN cord-346964-9afuen7k 382 3 Whipple Whipple NNP cord-346964-9afuen7k 382 4 's 's POS cord-346964-9afuen7k 382 5 disease disease NN cord-346964-9afuen7k 382 6 is be VBZ cord-346964-9afuen7k 382 7 due due JJ cord-346964-9afuen7k 382 8 predominantly predominantly RB cord-346964-9afuen7k 382 9 to to TO cord-346964-9afuen7k 382 10 blockage blockage VB cord-346964-9afuen7k 382 11 of of IN cord-346964-9afuen7k 382 12 nutrient nutrient NN cord-346964-9afuen7k 382 13 movement movement NN cord-346964-9afuen7k 382 14 in in IN cord-346964-9afuen7k 382 15 the the DT cord-346964-9afuen7k 382 16 lamina lamina JJ cord-346964-9afuen7k 382 17 propria propria NN cord-346964-9afuen7k 382 18 and and CC cord-346964-9afuen7k 382 19 in in IN cord-346964-9afuen7k 382 20 the the DT cord-346964-9afuen7k 382 21 mesenteric mesenteric JJ cord-346964-9afuen7k 382 22 lymphatic lymphatic JJ cord-346964-9afuen7k 382 23 drainage drainage NN cord-346964-9afuen7k 382 24 system system NN cord-346964-9afuen7k 382 25 by by IN cord-346964-9afuen7k 382 26 PAS pas NN cord-346964-9afuen7k 382 27 - - HYPH cord-346964-9afuen7k 382 28 positive positive JJ cord-346964-9afuen7k 382 29 macrophages macrophage NNS cord-346964-9afuen7k 382 30 . . . cord-346964-9afuen7k 383 1 Lipid lipid NN cord-346964-9afuen7k 383 2 accumulation accumulation NN cord-346964-9afuen7k 383 3 in in IN cord-346964-9afuen7k 383 4 the the DT cord-346964-9afuen7k 383 5 mucosa mucosa JJ cord-346964-9afuen7k 383 6 and and CC cord-346964-9afuen7k 383 7 mesenteric mesenteric JJ cord-346964-9afuen7k 383 8 lymph lymph NN cord-346964-9afuen7k 383 9 nodes node NNS cord-346964-9afuen7k 383 10 is be VBZ cord-346964-9afuen7k 383 11 a a DT cord-346964-9afuen7k 383 12 prominent prominent JJ cord-346964-9afuen7k 383 13 feature feature NN cord-346964-9afuen7k 383 14 in in IN cord-346964-9afuen7k 383 15 the the DT cord-346964-9afuen7k 383 16 small small JJ cord-346964-9afuen7k 383 17 intestine intestine NN cord-346964-9afuen7k 383 18 and and CC cord-346964-9afuen7k 383 19 led lead VBD cord-346964-9afuen7k 383 20 to to IN cord-346964-9afuen7k 383 21 Whipple Whipple NNP cord-346964-9afuen7k 383 22 's 's POS cord-346964-9afuen7k 383 23 name name NN cord-346964-9afuen7k 383 24 for for IN cord-346964-9afuen7k 383 25 the the DT cord-346964-9afuen7k 383 26 disorder disorder NN cord-346964-9afuen7k 383 27 -'intestinal -'intestinal IN cord-346964-9afuen7k 383 28 lipodystrophy lipodystrophy NNP cord-346964-9afuen7k 383 29 . . . cord-346964-9afuen7k 383 30 ' ' '' cord-346964-9afuen7k 384 1 The the DT cord-346964-9afuen7k 384 2 characteristic characteristic JJ cord-346964-9afuen7k 384 3 feature feature NN cord-346964-9afuen7k 384 4 in in IN cord-346964-9afuen7k 384 5 the the DT cord-346964-9afuen7k 384 6 small small JJ cord-346964-9afuen7k 384 7 intestinal intestinal JJ cord-346964-9afuen7k 384 8 biopsy biopsy NN cord-346964-9afuen7k 384 9 consists consist VBZ cord-346964-9afuen7k 384 10 of of IN cord-346964-9afuen7k 384 11 blunted blunted JJ cord-346964-9afuen7k 384 12 villi villi NN cord-346964-9afuen7k 384 13 with with IN cord-346964-9afuen7k 384 14 distended distended JJ cord-346964-9afuen7k 384 15 lamina lamina JJ cord-346964-9afuen7k 384 16 propria propria NN cord-346964-9afuen7k 384 17 resulting result VBG cord-346964-9afuen7k 384 18 from from IN cord-346964-9afuen7k 384 19 the the DT cord-346964-9afuen7k 384 20 accumulation accumulation NN cord-346964-9afuen7k 384 21 of of IN cord-346964-9afuen7k 384 22 foamy foamy JJ cord-346964-9afuen7k 384 23 histiocytes histiocyte NNS cord-346964-9afuen7k 384 24 containing contain VBG cord-346964-9afuen7k 384 25 PAS pas NN cord-346964-9afuen7k 384 26 - - HYPH cord-346964-9afuen7k 384 27 positive positive JJ cord-346964-9afuen7k 384 28 rod rod NN cord-346964-9afuen7k 384 29 - - HYPH cord-346964-9afuen7k 384 30 shaped shape VBN cord-346964-9afuen7k 384 31 , , , cord-346964-9afuen7k 384 32 rounded rounded JJ cord-346964-9afuen7k 384 33 , , , cord-346964-9afuen7k 384 34 or or CC cord-346964-9afuen7k 384 35 sickle sickle NN cord-346964-9afuen7k 384 36 - - HYPH cord-346964-9afuen7k 384 37 shaped shape VBN cord-346964-9afuen7k 384 38 bacilli bacilli NN cord-346964-9afuen7k 384 39 . . . cord-346964-9afuen7k 385 1 Mycobacterium Mycobacterium NNP cord-346964-9afuen7k 385 2 avium avium NN cord-346964-9afuen7k 385 3 - - HYPH cord-346964-9afuen7k 385 4 intracellulare intracellulare JJ cord-346964-9afuen7k 385 5 complex complex NN cord-346964-9afuen7k 385 6 ( ( -LRB- cord-346964-9afuen7k 385 7 MAI MAI NNP cord-346964-9afuen7k 385 8 ) ) -RRB- cord-346964-9afuen7k 385 9 is be VBZ cord-346964-9afuen7k 385 10 a a DT cord-346964-9afuen7k 385 11 significant significant JJ cord-346964-9afuen7k 385 12 cause cause NN cord-346964-9afuen7k 385 13 of of IN cord-346964-9afuen7k 385 14 opportunistic opportunistic JJ cord-346964-9afuen7k 385 15 infection infection NN cord-346964-9afuen7k 385 16 in in IN cord-346964-9afuen7k 385 17 immunocompromised immunocompromised JJ cord-346964-9afuen7k 385 18 individuals individual NNS cord-346964-9afuen7k 385 19 , , , cord-346964-9afuen7k 385 20 particularly particularly RB cord-346964-9afuen7k 385 21 those those DT cord-346964-9afuen7k 385 22 with with IN cord-346964-9afuen7k 385 23 AIDS AIDS NNP cord-346964-9afuen7k 385 24 , , , cord-346964-9afuen7k 385 25 particularly particularly RB cord-346964-9afuen7k 385 26 in in IN cord-346964-9afuen7k 385 27 the the DT cord-346964-9afuen7k 385 28 pre pre JJ cord-346964-9afuen7k 385 29 - - JJ cord-346964-9afuen7k 385 30 HAART HAART NNP cord-346964-9afuen7k 385 31 ( ( -LRB- cord-346964-9afuen7k 385 32 highly highly RB cord-346964-9afuen7k 385 33 active active JJ cord-346964-9afuen7k 385 34 antiretroviral antiretroviral JJ cord-346964-9afuen7k 385 35 treatment treatment NN cord-346964-9afuen7k 385 36 ) ) -RRB- cord-346964-9afuen7k 385 37 era era NN cord-346964-9afuen7k 385 38 . . . cord-346964-9afuen7k 386 1 The the DT cord-346964-9afuen7k 386 2 organism organism NN cord-346964-9afuen7k 386 3 is be VBZ cord-346964-9afuen7k 386 4 acquired acquire VBN cord-346964-9afuen7k 386 5 through through IN cord-346964-9afuen7k 386 6 exposure exposure NN cord-346964-9afuen7k 386 7 to to IN cord-346964-9afuen7k 386 8 aerosols aerosol NNS cord-346964-9afuen7k 386 9 , , , cord-346964-9afuen7k 386 10 food food NN cord-346964-9afuen7k 386 11 , , , cord-346964-9afuen7k 386 12 water water NN cord-346964-9afuen7k 386 13 , , , cord-346964-9afuen7k 386 14 and and CC cord-346964-9afuen7k 386 15 soil soil NN cord-346964-9afuen7k 386 16 . . . cord-346964-9afuen7k 387 1 The the DT cord-346964-9afuen7k 387 2 GI GI NNP cord-346964-9afuen7k 387 3 tract tract NN cord-346964-9afuen7k 387 4 is be VBZ cord-346964-9afuen7k 387 5 affected affect VBN cord-346964-9afuen7k 387 6 twice twice RB cord-346964-9afuen7k 387 7 as as RB cord-346964-9afuen7k 387 8 frequently frequently RB cord-346964-9afuen7k 387 9 as as IN cord-346964-9afuen7k 387 10 the the DT cord-346964-9afuen7k 387 11 lungs lung NNS cord-346964-9afuen7k 387 12 , , , cord-346964-9afuen7k 387 13 the the DT cord-346964-9afuen7k 387 14 small small JJ cord-346964-9afuen7k 387 15 intestine intestine NN cord-346964-9afuen7k 387 16 being be VBG cord-346964-9afuen7k 387 17 the the DT cord-346964-9afuen7k 387 18 preferred preferred JJ cord-346964-9afuen7k 387 19 site site NN cord-346964-9afuen7k 387 20 . . . cord-346964-9afuen7k 388 1 Healthy healthy JJ cord-346964-9afuen7k 388 2 people people NNS cord-346964-9afuen7k 388 3 do do VBP cord-346964-9afuen7k 388 4 not not RB cord-346964-9afuen7k 388 5 develop develop VB cord-346964-9afuen7k 388 6 active active JJ cord-346964-9afuen7k 388 7 disease disease NN cord-346964-9afuen7k 388 8 after after IN cord-346964-9afuen7k 388 9 exposure exposure NN cord-346964-9afuen7k 388 10 , , , cord-346964-9afuen7k 388 11 while while IN cord-346964-9afuen7k 388 12 those those DT cord-346964-9afuen7k 388 13 with with IN cord-346964-9afuen7k 388 14 a a DT cord-346964-9afuen7k 388 15 low low JJ cord-346964-9afuen7k 388 16 CD4 CD4 NNP cord-346964-9afuen7k 388 17 þ þ NNP cord-346964-9afuen7k 388 18 T t NN cord-346964-9afuen7k 388 19 - - HYPH cord-346964-9afuen7k 388 20 cell cell NN cord-346964-9afuen7k 388 21 count count NN cord-346964-9afuen7k 388 22 are be VBP cord-346964-9afuen7k 388 23 at at IN cord-346964-9afuen7k 388 24 risk risk NN cord-346964-9afuen7k 388 25 . . . cord-346964-9afuen7k 389 1 Patients patient NNS cord-346964-9afuen7k 389 2 suffer suffer VBP cord-346964-9afuen7k 389 3 from from IN cord-346964-9afuen7k 389 4 malabsorption malabsorption NN cord-346964-9afuen7k 389 5 , , , cord-346964-9afuen7k 389 6 abdominal abdominal JJ cord-346964-9afuen7k 389 7 pain pain NN cord-346964-9afuen7k 389 8 , , , cord-346964-9afuen7k 389 9 fever fever NN cord-346964-9afuen7k 389 10 , , , cord-346964-9afuen7k 389 11 and and CC cord-346964-9afuen7k 389 12 weight weight NN cord-346964-9afuen7k 389 13 loss loss NN cord-346964-9afuen7k 389 14 . . . cord-346964-9afuen7k 390 1 Small small JJ cord-346964-9afuen7k 390 2 intestinal intestinal JJ cord-346964-9afuen7k 390 3 biopsy biopsy NN cord-346964-9afuen7k 390 4 reveals reveal VBZ cord-346964-9afuen7k 390 5 villous villous JJ cord-346964-9afuen7k 390 6 blunting blunting NN cord-346964-9afuen7k 390 7 and and CC cord-346964-9afuen7k 390 8 distension distension NN cord-346964-9afuen7k 390 9 of of IN cord-346964-9afuen7k 390 10 the the DT cord-346964-9afuen7k 390 11 lamina lamina JJ cord-346964-9afuen7k 390 12 propria propria FW cord-346964-9afuen7k 390 13 by by IN cord-346964-9afuen7k 390 14 histiocytes histiocyte NNS cord-346964-9afuen7k 390 15 loaded load VBN cord-346964-9afuen7k 390 16 with with IN cord-346964-9afuen7k 390 17 acid acid NN cord-346964-9afuen7k 390 18 - - HYPH cord-346964-9afuen7k 390 19 fast fast JJ cord-346964-9afuen7k 390 20 bacilli bacilli NN cord-346964-9afuen7k 390 21 without without IN cord-346964-9afuen7k 390 22 well well RB cord-346964-9afuen7k 390 23 - - HYPH cord-346964-9afuen7k 390 24 formed form VBN cord-346964-9afuen7k 390 25 granulomas granuloma NNS cord-346964-9afuen7k 390 26 that that WDT cord-346964-9afuen7k 390 27 may may MD cord-346964-9afuen7k 390 28 be be VB cord-346964-9afuen7k 390 29 present present JJ cord-346964-9afuen7k 390 30 in in IN cord-346964-9afuen7k 390 31 immunocompetent immunocompetent JJ cord-346964-9afuen7k 390 32 hosts host NNS cord-346964-9afuen7k 390 33 . . . cord-346964-9afuen7k 391 1 Fungal fungal JJ cord-346964-9afuen7k 391 2 infections infection NNS cord-346964-9afuen7k 391 3 of of IN cord-346964-9afuen7k 391 4 the the DT cord-346964-9afuen7k 391 5 GI GI NNP cord-346964-9afuen7k 391 6 tract tract NN cord-346964-9afuen7k 391 7 have have VBP cord-346964-9afuen7k 391 8 become become VBN cord-346964-9afuen7k 391 9 more more RBR cord-346964-9afuen7k 391 10 common common JJ cord-346964-9afuen7k 391 11 over over IN cord-346964-9afuen7k 391 12 the the DT cord-346964-9afuen7k 391 13 years year NNS cord-346964-9afuen7k 391 14 as as IN cord-346964-9afuen7k 391 15 numbers number NNS cord-346964-9afuen7k 391 16 of of IN cord-346964-9afuen7k 391 17 patients patient NNS cord-346964-9afuen7k 391 18 with with IN cord-346964-9afuen7k 391 19 organ organ NN cord-346964-9afuen7k 391 20 transplants transplant NNS cord-346964-9afuen7k 391 21 , , , cord-346964-9afuen7k 391 22 AIDS AIDS NNP cord-346964-9afuen7k 391 23 , , , cord-346964-9afuen7k 391 24 and and CC cord-346964-9afuen7k 391 25 other other JJ cord-346964-9afuen7k 391 26 immunodeficiencies immunodeficiency NNS cord-346964-9afuen7k 391 27 have have VBP cord-346964-9afuen7k 391 28 increased increase VBN cord-346964-9afuen7k 391 29 . . . cord-346964-9afuen7k 392 1 GI GI NNP cord-346964-9afuen7k 392 2 fungal fungal NN cord-346964-9afuen7k 392 3 pathogens pathogen NNS cord-346964-9afuen7k 392 4 predominantly predominantly RB cord-346964-9afuen7k 392 5 affect affect VBP cord-346964-9afuen7k 392 6 the the DT cord-346964-9afuen7k 392 7 immunocompromised immunocompromised JJ cord-346964-9afuen7k 392 8 individuals individual NNS cord-346964-9afuen7k 392 9 as as IN cord-346964-9afuen7k 392 10 opportunistic opportunistic JJ cord-346964-9afuen7k 392 11 infections infection NNS cord-346964-9afuen7k 392 12 . . . cord-346964-9afuen7k 393 1 Almost almost RB cord-346964-9afuen7k 393 2 all all DT cord-346964-9afuen7k 393 3 fungi fungus NNS cord-346964-9afuen7k 393 4 may may MD cord-346964-9afuen7k 393 5 involve involve VB cord-346964-9afuen7k 393 6 the the DT cord-346964-9afuen7k 393 7 small small JJ cord-346964-9afuen7k 393 8 intestine intestine NN cord-346964-9afuen7k 393 9 during during IN cord-346964-9afuen7k 393 10 the the DT cord-346964-9afuen7k 393 11 disseminated disseminate VBN cord-346964-9afuen7k 393 12 GI GI NNP cord-346964-9afuen7k 393 13 involvement involvement NN cord-346964-9afuen7k 393 14 but but CC cord-346964-9afuen7k 393 15 Histoplasma Histoplasma NNP cord-346964-9afuen7k 393 16 and and CC cord-346964-9afuen7k 393 17 Cryptococcus Cryptococcus NNP cord-346964-9afuen7k 393 18 have have VBP cord-346964-9afuen7k 393 19 particular particular JJ cord-346964-9afuen7k 393 20 predilection predilection NN cord-346964-9afuen7k 393 21 for for IN cord-346964-9afuen7k 393 22 the the DT cord-346964-9afuen7k 393 23 small small JJ cord-346964-9afuen7k 393 24 intestine intestine NN cord-346964-9afuen7k 393 25 and and CC cord-346964-9afuen7k 393 26 colon colon NN cord-346964-9afuen7k 393 27 . . . cord-346964-9afuen7k 394 1 Histoplasma Histoplasma NNP cord-346964-9afuen7k 394 2 capsulatum capsulatum NN cord-346964-9afuen7k 394 3 commonly commonly RB cord-346964-9afuen7k 394 4 involves involve VBZ cord-346964-9afuen7k 394 5 the the DT cord-346964-9afuen7k 394 6 ileum ileum NN cord-346964-9afuen7k 394 7 causing cause VBG cord-346964-9afuen7k 394 8 ulcers ulcer NNS cord-346964-9afuen7k 394 9 and and CC cord-346964-9afuen7k 394 10 obstructive obstructive JJ cord-346964-9afuen7k 394 11 masses masse NNS cord-346964-9afuen7k 394 12 in in IN cord-346964-9afuen7k 394 13 the the DT cord-346964-9afuen7k 394 14 lumen lumen NN cord-346964-9afuen7k 394 15 . . . cord-346964-9afuen7k 395 1 Histologically histologically RB cord-346964-9afuen7k 395 2 , , , cord-346964-9afuen7k 395 3 lymphohistiocytic lymphohistiocytic JJ cord-346964-9afuen7k 395 4 infiltration infiltration NN cord-346964-9afuen7k 395 5 usually usually RB cord-346964-9afuen7k 395 6 involving involve VBG cord-346964-9afuen7k 395 7 the the DT cord-346964-9afuen7k 395 8 mucosa mucosa JJ cord-346964-9afuen7k 395 9 and and CC cord-346964-9afuen7k 395 10 submucosa submucosa NNS cord-346964-9afuen7k 395 11 with with IN cord-346964-9afuen7k 395 12 ulceration ulceration NN cord-346964-9afuen7k 395 13 , , , cord-346964-9afuen7k 395 14 resembling resemble VBG cord-346964-9afuen7k 395 15 WD WD NNP cord-346964-9afuen7k 395 16 , , , cord-346964-9afuen7k 395 17 is be VBZ cord-346964-9afuen7k 395 18 observed observe VBN cord-346964-9afuen7k 395 19 . . . cord-346964-9afuen7k 396 1 Granulomas granuloma NNS cord-346964-9afuen7k 396 2 are be VBP cord-346964-9afuen7k 396 3 only only RB cord-346964-9afuen7k 396 4 present present JJ cord-346964-9afuen7k 396 5 in in IN cord-346964-9afuen7k 396 6 a a DT cord-346964-9afuen7k 396 7 small small JJ cord-346964-9afuen7k 396 8 percentage percentage NN cord-346964-9afuen7k 396 9 of of IN cord-346964-9afuen7k 396 10 cases case NNS cord-346964-9afuen7k 396 11 . . . cord-346964-9afuen7k 397 1 Histoplasma histoplasma NN cord-346964-9afuen7k 397 2 organisms organism NNS cord-346964-9afuen7k 397 3 are be VBP cord-346964-9afuen7k 397 4 present present JJ cord-346964-9afuen7k 397 5 in in IN cord-346964-9afuen7k 397 6 the the DT cord-346964-9afuen7k 397 7 cytoplasm cytoplasm NN cord-346964-9afuen7k 397 8 of of IN cord-346964-9afuen7k 397 9 histiocytes histiocyte NNS cord-346964-9afuen7k 397 10 as as IN cord-346964-9afuen7k 397 11 ovoid ovoid JJ cord-346964-9afuen7k 397 12 yeast yeast NN cord-346964-9afuen7k 397 13 forms form NNS cord-346964-9afuen7k 397 14 . . . cord-346964-9afuen7k 398 1 Cryptococcus Cryptococcus NNP cord-346964-9afuen7k 398 2 neoformans neoforman NNS cord-346964-9afuen7k 398 3 may may MD cord-346964-9afuen7k 398 4 involve involve VB cord-346964-9afuen7k 398 5 the the DT cord-346964-9afuen7k 398 6 GI GI NNP cord-346964-9afuen7k 398 7 tract tract NN cord-346964-9afuen7k 398 8 in in IN cord-346964-9afuen7k 398 9 patients patient NNS cord-346964-9afuen7k 398 10 with with IN cord-346964-9afuen7k 398 11 disseminated disseminate VBN cord-346964-9afuen7k 398 12 disease disease NN cord-346964-9afuen7k 398 13 . . . cord-346964-9afuen7k 399 1 Histological Histological NNP cord-346964-9afuen7k 399 2 features feature NNS cord-346964-9afuen7k 399 3 include include VBP cord-346964-9afuen7k 399 4 round round JJ cord-346964-9afuen7k 399 5 to to IN cord-346964-9afuen7k 399 6 oval oval JJ cord-346964-9afuen7k 399 7 yeast yeast NN cord-346964-9afuen7k 399 8 forms form NNS cord-346964-9afuen7k 399 9 with with IN cord-346964-9afuen7k 399 10 budding budding JJ cord-346964-9afuen7k 399 11 and and CC cord-346964-9afuen7k 399 12 occasional occasional JJ cord-346964-9afuen7k 399 13 hyphae hypha NNS cord-346964-9afuen7k 399 14 or or CC cord-346964-9afuen7k 399 15 pseudohyphae pseudohyphae NN cord-346964-9afuen7k 399 16 . . . cord-346964-9afuen7k 400 1 There there EX cord-346964-9afuen7k 400 2 may may MD cord-346964-9afuen7k 400 3 be be VB cord-346964-9afuen7k 400 4 necrotizing necrotize VBG cord-346964-9afuen7k 400 5 , , , cord-346964-9afuen7k 400 6 suppurative suppurative JJ cord-346964-9afuen7k 400 7 inflammation inflammation NN cord-346964-9afuen7k 400 8 and and CC cord-346964-9afuen7k 400 9 granuloma granuloma NN cord-346964-9afuen7k 400 10 formation formation NN cord-346964-9afuen7k 400 11 in in IN cord-346964-9afuen7k 400 12 many many JJ cord-346964-9afuen7k 400 13 cases case NNS cord-346964-9afuen7k 400 14 . . . cord-346964-9afuen7k 401 1 Giardiasis giardiasis NN cord-346964-9afuen7k 401 2 is be VBZ cord-346964-9afuen7k 401 3 the the DT cord-346964-9afuen7k 401 4 leading lead VBG cord-346964-9afuen7k 401 5 GI GI NNP cord-346964-9afuen7k 401 6 protozoan protozoan NN cord-346964-9afuen7k 401 7 disease disease NN cord-346964-9afuen7k 401 8 worldwide worldwide RB cord-346964-9afuen7k 401 9 with with IN cord-346964-9afuen7k 401 10 an an DT cord-346964-9afuen7k 401 11 increase increase NN cord-346964-9afuen7k 401 12 in in IN cord-346964-9afuen7k 401 13 summer summer NN cord-346964-9afuen7k 401 14 and and CC cord-346964-9afuen7k 401 15 autumn autumn NN cord-346964-9afuen7k 401 16 . . . cord-346964-9afuen7k 402 1 Infection infection NN cord-346964-9afuen7k 402 2 occurs occur VBZ cord-346964-9afuen7k 402 3 by by IN cord-346964-9afuen7k 402 4 fecaloral fecaloral JJ cord-346964-9afuen7k 402 5 transmission transmission NN cord-346964-9afuen7k 402 6 , , , cord-346964-9afuen7k 402 7 contaminated contaminate VBN cord-346964-9afuen7k 402 8 food food NN cord-346964-9afuen7k 402 9 and and CC cord-346964-9afuen7k 402 10 water water NN cord-346964-9afuen7k 402 11 , , , cord-346964-9afuen7k 402 12 and and CC cord-346964-9afuen7k 402 13 personto personto NN cord-346964-9afuen7k 402 14 - - HYPH cord-346964-9afuen7k 402 15 person person NN cord-346964-9afuen7k 402 16 transmission transmission NN cord-346964-9afuen7k 402 17 . . . cord-346964-9afuen7k 403 1 A a DT cord-346964-9afuen7k 403 2 number number NN cord-346964-9afuen7k 403 3 of of IN cord-346964-9afuen7k 403 4 studies study NNS cord-346964-9afuen7k 403 5 have have VBP cord-346964-9afuen7k 403 6 found find VBN cord-346964-9afuen7k 403 7 that that IN cord-346964-9afuen7k 403 8 children child NNS cord-346964-9afuen7k 403 9 and and CC cord-346964-9afuen7k 403 10 patients patient NNS cord-346964-9afuen7k 403 11 with with IN cord-346964-9afuen7k 403 12 hypogammaglobulinemia hypogammaglobulinemia NNP cord-346964-9afuen7k 403 13 , , , cord-346964-9afuen7k 403 14 agammaglobulinemia agammaglobulinemia NNP cord-346964-9afuen7k 403 15 , , , cord-346964-9afuen7k 403 16 IgA IgA NNP cord-346964-9afuen7k 403 17 deficiency deficiency NN cord-346964-9afuen7k 403 18 , , , cord-346964-9afuen7k 403 19 and/or and/or CC cord-346964-9afuen7k 403 20 achlorhydria achlorhydria NNP cord-346964-9afuen7k 403 21 have have VBP cord-346964-9afuen7k 403 22 a a DT cord-346964-9afuen7k 403 23 higher high JJR cord-346964-9afuen7k 403 24 incidence incidence NN cord-346964-9afuen7k 403 25 of of IN cord-346964-9afuen7k 403 26 infection infection NN cord-346964-9afuen7k 403 27 with with IN cord-346964-9afuen7k 403 28 Giardia Giardia NNP cord-346964-9afuen7k 403 29 . . . cord-346964-9afuen7k 404 1 However however RB cord-346964-9afuen7k 404 2 , , , cord-346964-9afuen7k 404 3 a a DT cord-346964-9afuen7k 404 4 humoral humoral JJ cord-346964-9afuen7k 404 5 immunodeficiency immunodeficiency NN cord-346964-9afuen7k 404 6 state state NN cord-346964-9afuen7k 404 7 is be VBZ cord-346964-9afuen7k 404 8 not not RB cord-346964-9afuen7k 404 9 necessary necessary JJ cord-346964-9afuen7k 404 10 for for IN cord-346964-9afuen7k 404 11 infection infection NN cord-346964-9afuen7k 404 12 . . . cord-346964-9afuen7k 405 1 Immunosuppressed immunosuppressed JJ cord-346964-9afuen7k 405 2 patients patient NNS cord-346964-9afuen7k 405 3 are be VBP cord-346964-9afuen7k 405 4 more more RBR cord-346964-9afuen7k 405 5 likely likely JJ cord-346964-9afuen7k 405 6 to to TO cord-346964-9afuen7k 405 7 have have VB cord-346964-9afuen7k 405 8 long long JJ cord-346964-9afuen7k 405 9 - - HYPH cord-346964-9afuen7k 405 10 term term NN cord-346964-9afuen7k 405 11 infections infection NNS cord-346964-9afuen7k 405 12 with with IN cord-346964-9afuen7k 405 13 chronic chronic JJ cord-346964-9afuen7k 405 14 diarrhea diarrhea NN cord-346964-9afuen7k 405 15 and and CC cord-346964-9afuen7k 405 16 malabsorption malabsorption NN cord-346964-9afuen7k 405 17 , , , cord-346964-9afuen7k 405 18 while while IN cord-346964-9afuen7k 405 19 immunocompetent immunocompetent JJ cord-346964-9afuen7k 405 20 patients patient NNS cord-346964-9afuen7k 405 21 are be VBP cord-346964-9afuen7k 405 22 more more RBR cord-346964-9afuen7k 405 23 likely likely JJ cord-346964-9afuen7k 405 24 to to TO cord-346964-9afuen7k 405 25 have have VB cord-346964-9afuen7k 405 26 an an DT cord-346964-9afuen7k 405 27 acute acute JJ cord-346964-9afuen7k 405 28 self self NN cord-346964-9afuen7k 405 29 - - HYPH cord-346964-9afuen7k 405 30 limited limit VBN cord-346964-9afuen7k 405 31 diarrheal diarrheal JJ cord-346964-9afuen7k 405 32 illness illness NN cord-346964-9afuen7k 405 33 or or CC cord-346964-9afuen7k 405 34 become become VB cord-346964-9afuen7k 405 35 asymptomatic asymptomatic JJ cord-346964-9afuen7k 405 36 carriers carrier NNS cord-346964-9afuen7k 405 37 . . . cord-346964-9afuen7k 406 1 In in IN cord-346964-9afuen7k 406 2 its -PRON- PRP$ cord-346964-9afuen7k 406 3 classical classical JJ cord-346964-9afuen7k 406 4 picture picture NN cord-346964-9afuen7k 406 5 , , , cord-346964-9afuen7k 406 6 diarrhea diarrhea NN cord-346964-9afuen7k 406 7 , , , cord-346964-9afuen7k 406 8 abdominal abdominal JJ cord-346964-9afuen7k 406 9 pain pain NN cord-346964-9afuen7k 406 10 , , , cord-346964-9afuen7k 406 11 boating boating NN cord-346964-9afuen7k 406 12 , , , cord-346964-9afuen7k 406 13 nausea nausea NN cord-346964-9afuen7k 406 14 and and CC cord-346964-9afuen7k 406 15 vomiting vomiting NN cord-346964-9afuen7k 406 16 , , , cord-346964-9afuen7k 406 17 malabsorption malabsorption NN cord-346964-9afuen7k 406 18 , , , cord-346964-9afuen7k 406 19 and and CC cord-346964-9afuen7k 406 20 weight weight NN cord-346964-9afuen7k 406 21 loss loss NN cord-346964-9afuen7k 406 22 are be VBP cord-346964-9afuen7k 406 23 the the DT cord-346964-9afuen7k 406 24 main main JJ cord-346964-9afuen7k 406 25 presenting present VBG cord-346964-9afuen7k 406 26 symptoms symptom NNS cord-346964-9afuen7k 406 27 . . . cord-346964-9afuen7k 407 1 Giardia Giardia NNP cord-346964-9afuen7k 407 2 exists exist VBZ cord-346964-9afuen7k 407 3 in in IN cord-346964-9afuen7k 407 4 two two CD cord-346964-9afuen7k 407 5 forms form NNS cord-346964-9afuen7k 407 6 : : : cord-346964-9afuen7k 407 7 the the DT cord-346964-9afuen7k 407 8 motile motile NNP cord-346964-9afuen7k 407 9 trophozoite trophozoite NNP cord-346964-9afuen7k 407 10 and and CC cord-346964-9afuen7k 407 11 the the DT cord-346964-9afuen7k 407 12 infective infective JJ cord-346964-9afuen7k 407 13 cyst cyst NN cord-346964-9afuen7k 407 14 . . . cord-346964-9afuen7k 408 1 Following follow VBG cord-346964-9afuen7k 408 2 ingestion ingestion NN cord-346964-9afuen7k 408 3 , , , cord-346964-9afuen7k 408 4 the the DT cord-346964-9afuen7k 408 5 cyst cyst NN cord-346964-9afuen7k 408 6 forms form VBZ cord-346964-9afuen7k 408 7 two two CD cord-346964-9afuen7k 408 8 trophozoites trophozoite NNS cord-346964-9afuen7k 408 9 in in IN cord-346964-9afuen7k 408 10 the the DT cord-346964-9afuen7k 408 11 duodenum duodenum NN cord-346964-9afuen7k 408 12 . . . cord-346964-9afuen7k 409 1 These these DT cord-346964-9afuen7k 409 2 are be VBP cord-346964-9afuen7k 409 3 pearshaped pearshaped JJ cord-346964-9afuen7k 409 4 with with IN cord-346964-9afuen7k 409 5 two two CD cord-346964-9afuen7k 409 6 nuclei nucleus NNS cord-346964-9afuen7k 409 7 or or CC cord-346964-9afuen7k 409 8 sickle sickle NN cord-346964-9afuen7k 409 9 - - HYPH cord-346964-9afuen7k 409 10 shaped shape VBN cord-346964-9afuen7k 409 11 in in IN cord-346964-9afuen7k 409 12 sagittal sagittal JJ cord-346964-9afuen7k 409 13 plane plane NN cord-346964-9afuen7k 409 14 appearing appear VBG cord-346964-9afuen7k 409 15 faintly faintly RB cord-346964-9afuen7k 409 16 basophilic basophilic JJ cord-346964-9afuen7k 409 17 on on IN cord-346964-9afuen7k 409 18 H&E H&E NNP cord-346964-9afuen7k 409 19 sections section NNS cord-346964-9afuen7k 409 20 . . . cord-346964-9afuen7k 410 1 Trophozoites trophozoite NNS cord-346964-9afuen7k 410 2 are be VBP cord-346964-9afuen7k 410 3 typically typically RB cord-346964-9afuen7k 410 4 found find VBN cord-346964-9afuen7k 410 5 in in IN cord-346964-9afuen7k 410 6 the the DT cord-346964-9afuen7k 410 7 lumen lumen NN cord-346964-9afuen7k 410 8 near near IN cord-346964-9afuen7k 410 9 the the DT cord-346964-9afuen7k 410 10 surface surface NN cord-346964-9afuen7k 410 11 or or CC cord-346964-9afuen7k 410 12 as as IN cord-346964-9afuen7k 410 13 attached attach VBN cord-346964-9afuen7k 410 14 to to IN cord-346964-9afuen7k 410 15 the the DT cord-346964-9afuen7k 410 16 enterocytes enterocyte NNS cord-346964-9afuen7k 410 17 ( ( -LRB- cord-346964-9afuen7k 410 18 Figure figure NN cord-346964-9afuen7k 410 19 20 20 CD cord-346964-9afuen7k 410 20 ( ( -LRB- cord-346964-9afuen7k 410 21 a a LS cord-346964-9afuen7k 410 22 ) ) -RRB- cord-346964-9afuen7k 410 23 and and CC cord-346964-9afuen7k 410 24 20(b 20(b LS cord-346964-9afuen7k 410 25 ) ) -RRB- cord-346964-9afuen7k 410 26 ) ) -RRB- cord-346964-9afuen7k 410 27 . . . cord-346964-9afuen7k 411 1 Giardiasis giardiasis NN cord-346964-9afuen7k 411 2 is be VBZ cord-346964-9afuen7k 411 3 a a DT cord-346964-9afuen7k 411 4 typical typical JJ cord-346964-9afuen7k 411 5 example example NN cord-346964-9afuen7k 411 6 of of IN cord-346964-9afuen7k 411 7 enteric enteric JJ cord-346964-9afuen7k 411 8 infection infection NN cord-346964-9afuen7k 411 9 that that WDT cord-346964-9afuen7k 411 10 presents present VBZ cord-346964-9afuen7k 411 11 with with IN cord-346964-9afuen7k 411 12 normal normal JJ cord-346964-9afuen7k 411 13 or or CC cord-346964-9afuen7k 411 14 near near RB cord-346964-9afuen7k 411 15 - - HYPH cord-346964-9afuen7k 411 16 normal normal JJ cord-346964-9afuen7k 411 17 mucosa mucosa NN cord-346964-9afuen7k 411 18 , , , cord-346964-9afuen7k 411 19 although although IN cord-346964-9afuen7k 411 20 more more RBR cord-346964-9afuen7k 411 21 severe severe JJ cord-346964-9afuen7k 411 22 change change NN cord-346964-9afuen7k 411 23 in in IN cord-346964-9afuen7k 411 24 the the DT cord-346964-9afuen7k 411 25 villous villous JJ cord-346964-9afuen7k 411 26 morphology morphology NN cord-346964-9afuen7k 411 27 resembling resemble VBG cord-346964-9afuen7k 411 28 CD CD NNP cord-346964-9afuen7k 411 29 may may MD cord-346964-9afuen7k 411 30 rarely rarely RB cord-346964-9afuen7k 411 31 be be VB cord-346964-9afuen7k 411 32 seen see VBN cord-346964-9afuen7k 411 33 . . . cord-346964-9afuen7k 412 1 In in IN cord-346964-9afuen7k 412 2 children child NNS cord-346964-9afuen7k 412 3 , , , cord-346964-9afuen7k 412 4 giardiasis giardiasis NN cord-346964-9afuen7k 412 5 can can MD cord-346964-9afuen7k 412 6 cause cause VB cord-346964-9afuen7k 412 7 lymphoid lymphoid JJ cord-346964-9afuen7k 412 8 hyperplasia hyperplasia NN cord-346964-9afuen7k 412 9 in in IN cord-346964-9afuen7k 412 10 the the DT cord-346964-9afuen7k 412 11 small small JJ cord-346964-9afuen7k 412 12 intestinal intestinal JJ cord-346964-9afuen7k 412 13 mucosa mucosa NN cord-346964-9afuen7k 412 14 . . . cord-346964-9afuen7k 413 1 Coccidial coccidial JJ cord-346964-9afuen7k 413 2 infections infection NNS cord-346964-9afuen7k 413 3 are be VBP cord-346964-9afuen7k 413 4 commonly commonly RB cord-346964-9afuen7k 413 5 observed observe VBN cord-346964-9afuen7k 413 6 in in IN cord-346964-9afuen7k 413 7 immunocompromised immunocompromised JJ cord-346964-9afuen7k 413 8 patients patient NNS cord-346964-9afuen7k 413 9 , , , cord-346964-9afuen7k 413 10 particularly particularly RB cord-346964-9afuen7k 413 11 those those DT cord-346964-9afuen7k 413 12 with with IN cord-346964-9afuen7k 413 13 AIDS AIDS NNP cord-346964-9afuen7k 413 14 . . . cord-346964-9afuen7k 414 1 However however RB cord-346964-9afuen7k 414 2 , , , cord-346964-9afuen7k 414 3 all all DT cord-346964-9afuen7k 414 4 except except IN cord-346964-9afuen7k 414 5 microsporidia microsporidia NNP cord-346964-9afuen7k 414 6 may may MD cord-346964-9afuen7k 414 7 also also RB cord-346964-9afuen7k 414 8 infect infect VB cord-346964-9afuen7k 414 9 healthy healthy JJ cord-346964-9afuen7k 414 10 individual individual NN cord-346964-9afuen7k 414 11 and and CC cord-346964-9afuen7k 414 12 cause cause VB cord-346964-9afuen7k 414 13 diarrhea diarrhea NN cord-346964-9afuen7k 414 14 accompanied accompany VBN cord-346964-9afuen7k 414 15 by by IN cord-346964-9afuen7k 414 16 fever fever NN cord-346964-9afuen7k 414 17 , , , cord-346964-9afuen7k 414 18 weight weight NN cord-346964-9afuen7k 414 19 loss loss NN cord-346964-9afuen7k 414 20 , , , cord-346964-9afuen7k 414 21 and and CC cord-346964-9afuen7k 414 22 abdominal abdominal JJ cord-346964-9afuen7k 414 23 pain pain NN cord-346964-9afuen7k 414 24 . . . cord-346964-9afuen7k 415 1 The the DT cord-346964-9afuen7k 415 2 immunocompromised immunocompromised JJ cord-346964-9afuen7k 415 3 patients patient NNS cord-346964-9afuen7k 415 4 may may MD cord-346964-9afuen7k 415 5 suffer suffer VB cord-346964-9afuen7k 415 6 from from IN cord-346964-9afuen7k 415 7 malabsorption malabsorption NN cord-346964-9afuen7k 415 8 . . . cord-346964-9afuen7k 416 1 Among among IN cord-346964-9afuen7k 416 2 the the DT cord-346964-9afuen7k 416 3 most most RBS cord-346964-9afuen7k 416 4 common common JJ cord-346964-9afuen7k 416 5 coccidial coccidial JJ cord-346964-9afuen7k 416 6 organisms organism NNS cord-346964-9afuen7k 416 7 infecting infect VBG cord-346964-9afuen7k 416 8 the the DT cord-346964-9afuen7k 416 9 small small JJ cord-346964-9afuen7k 416 10 bowel bowel NN cord-346964-9afuen7k 416 11 are be VBP cord-346964-9afuen7k 416 12 Cryptosporidium cryptosporidium NN cord-346964-9afuen7k 416 13 parvum parvum NN cord-346964-9afuen7k 416 14 , , , cord-346964-9afuen7k 416 15 Cyclospora Cyclospora NNP cord-346964-9afuen7k 416 16 cayetanensis cayetanensis NN cord-346964-9afuen7k 416 17 , , , cord-346964-9afuen7k 416 18 Isospora Isospora NNP cord-346964-9afuen7k 416 19 belli belli NNP cord-346964-9afuen7k 416 20 , , , cord-346964-9afuen7k 416 21 Microsporidium Microsporidium NNP cord-346964-9afuen7k 416 22 , , , cord-346964-9afuen7k 416 23 cryptosporidia cryptosporidia NNP cord-346964-9afuen7k 416 24 , , , cord-346964-9afuen7k 416 25 microsporidia microsporidia NNP cord-346964-9afuen7k 416 26 , , , cord-346964-9afuen7k 416 27 and and CC cord-346964-9afuen7k 416 28 I. I. NNP cord-346964-9afuen7k 416 29 belli belli NNP cord-346964-9afuen7k 416 30 are be VBP cord-346964-9afuen7k 416 31 often often RB cord-346964-9afuen7k 416 32 missed miss VBN cord-346964-9afuen7k 416 33 , , , cord-346964-9afuen7k 416 34 because because IN cord-346964-9afuen7k 416 35 of of IN cord-346964-9afuen7k 416 36 their -PRON- PRP$ cord-346964-9afuen7k 416 37 small small JJ cord-346964-9afuen7k 416 38 size size NN cord-346964-9afuen7k 416 39 , , , cord-346964-9afuen7k 416 40 intracellular intracellular JJ cord-346964-9afuen7k 416 41 location location NN cord-346964-9afuen7k 416 42 , , , cord-346964-9afuen7k 416 43 and and CC cord-346964-9afuen7k 416 44 poor poor JJ cord-346964-9afuen7k 416 45 staining staining NN cord-346964-9afuen7k 416 46 with with IN cord-346964-9afuen7k 416 47 usual usual JJ cord-346964-9afuen7k 416 48 tissue tissue NN cord-346964-9afuen7k 416 49 stains stain NNS cord-346964-9afuen7k 416 50 thereby thereby RB cord-346964-9afuen7k 416 51 require require VBP cord-346964-9afuen7k 416 52 special special JJ cord-346964-9afuen7k 416 53 stains stain NNS cord-346964-9afuen7k 416 54 . . . cord-346964-9afuen7k 417 1 Cryptosporidiosis Cryptosporidiosis NNP cord-346964-9afuen7k 417 2 is be VBZ cord-346964-9afuen7k 417 3 usually usually RB cord-346964-9afuen7k 417 4 associated associate VBN cord-346964-9afuen7k 417 5 with with IN cord-346964-9afuen7k 417 6 normal normal JJ cord-346964-9afuen7k 417 7 duodenal duodenal JJ cord-346964-9afuen7k 417 8 histology histology NN cord-346964-9afuen7k 417 9 in in IN cord-346964-9afuen7k 417 10 mild mild JJ cord-346964-9afuen7k 417 11 infections infection NNS cord-346964-9afuen7k 417 12 , , , cord-346964-9afuen7k 417 13 whereas whereas IN cord-346964-9afuen7k 417 14 severe severe JJ cord-346964-9afuen7k 417 15 inflammation inflammation NN cord-346964-9afuen7k 417 16 and and CC cord-346964-9afuen7k 417 17 villous villous NN cord-346964-9afuen7k 417 18 atrophy atrophy NN cord-346964-9afuen7k 417 19 may may MD cord-346964-9afuen7k 417 20 complicate complicate VB cord-346964-9afuen7k 417 21 serious serious JJ cord-346964-9afuen7k 417 22 infections infection NNS cord-346964-9afuen7k 417 23 . . . cord-346964-9afuen7k 418 1 The the DT cord-346964-9afuen7k 418 2 diagnosis diagnosis NN cord-346964-9afuen7k 418 3 relies rely VBZ cord-346964-9afuen7k 418 4 on on IN cord-346964-9afuen7k 418 5 the the DT cord-346964-9afuen7k 418 6 detection detection NN cord-346964-9afuen7k 418 7 of of IN cord-346964-9afuen7k 418 8 tiny tiny JJ cord-346964-9afuen7k 418 9 acid acid NN cord-346964-9afuen7k 418 10 - - HYPH cord-346964-9afuen7k 418 11 fast fast JJ cord-346964-9afuen7k 418 12 oocytes oocyte NNS cord-346964-9afuen7k 418 13 in in IN cord-346964-9afuen7k 418 14 fresh fresh JJ cord-346964-9afuen7k 418 15 stools stool NNS cord-346964-9afuen7k 418 16 . . . cord-346964-9afuen7k 419 1 Its -PRON- PRP$ cord-346964-9afuen7k 419 2 characteristic characteristic JJ cord-346964-9afuen7k 419 3 appearance appearance NN cord-346964-9afuen7k 419 4 is be VBZ cord-346964-9afuen7k 419 5 a a DT cord-346964-9afuen7k 419 6 tiny tiny JJ cord-346964-9afuen7k 419 7 spherical spherical JJ cord-346964-9afuen7k 419 8 or or CC cord-346964-9afuen7k 419 9 ovoid ovoid JJ cord-346964-9afuen7k 419 10 basophilic basophilic JJ cord-346964-9afuen7k 419 11 organism organism NN cord-346964-9afuen7k 419 12 attached attach VBN cord-346964-9afuen7k 419 13 to to IN cord-346964-9afuen7k 419 14 the the DT cord-346964-9afuen7k 419 15 apical apical JJ cord-346964-9afuen7k 419 16 aspect aspect NN cord-346964-9afuen7k 419 17 of of IN cord-346964-9afuen7k 419 18 the the DT cord-346964-9afuen7k 419 19 enterocyte enterocyte NN cord-346964-9afuen7k 419 20 both both DT cord-346964-9afuen7k 419 21 in in IN cord-346964-9afuen7k 419 22 the the DT cord-346964-9afuen7k 419 23 surface surface NN cord-346964-9afuen7k 419 24 and and CC cord-346964-9afuen7k 419 25 crypt crypt NN cord-346964-9afuen7k 419 26 epithelium epithelium NN cord-346964-9afuen7k 419 27 ( ( -LRB- cord-346964-9afuen7k 419 28 Figure Figure NNP cord-346964-9afuen7k 419 29 21 21 CD cord-346964-9afuen7k 419 30 ) ) -RRB- cord-346964-9afuen7k 419 31 . . . cord-346964-9afuen7k 420 1 They -PRON- PRP cord-346964-9afuen7k 420 2 are be VBP cord-346964-9afuen7k 420 3 best well RBS cord-346964-9afuen7k 420 4 seen see VBN cord-346964-9afuen7k 420 5 with with IN cord-346964-9afuen7k 420 6 modified modify VBN cord-346964-9afuen7k 420 7 Kinyoun Kinyoun NNP cord-346964-9afuen7k 420 8 stain stain NN cord-346964-9afuen7k 420 9 . . . cord-346964-9afuen7k 421 1 Cyclospora Cyclospora NNP cord-346964-9afuen7k 421 2 is be VBZ cord-346964-9afuen7k 421 3 similar similar JJ cord-346964-9afuen7k 421 4 to to IN cord-346964-9afuen7k 421 5 Cryptosporidium cryptosporidium NN cord-346964-9afuen7k 422 1 but but CC cord-346964-9afuen7k 422 2 it -PRON- PRP cord-346964-9afuen7k 422 3 is be VBZ cord-346964-9afuen7k 422 4 larger large JJR cord-346964-9afuen7k 422 5 and and CC cord-346964-9afuen7k 422 6 is be VBZ cord-346964-9afuen7k 422 7 usually usually RB cord-346964-9afuen7k 422 8 found find VBN cord-346964-9afuen7k 422 9 in in IN cord-346964-9afuen7k 422 10 the the DT cord-346964-9afuen7k 422 11 enterocyte enterocyte NNP cord-346964-9afuen7k 422 12 cytoplasm cytoplasm NNP cord-346964-9afuen7k 422 13 . . . cord-346964-9afuen7k 423 1 They -PRON- PRP cord-346964-9afuen7k 423 2 stain stain VBP cord-346964-9afuen7k 423 3 with with IN cord-346964-9afuen7k 423 4 modified modify VBN cord-346964-9afuen7k 423 5 acid acid NN cord-346964-9afuen7k 423 6 - - HYPH cord-346964-9afuen7k 423 7 fast fast JJ cord-346964-9afuen7k 423 8 stains stain NNS cord-346964-9afuen7k 423 9 . . . cord-346964-9afuen7k 424 1 Isospora Isospora NNP cord-346964-9afuen7k 424 2 infection infection NN cord-346964-9afuen7k 424 3 may may MD cord-346964-9afuen7k 424 4 lead lead VB cord-346964-9afuen7k 424 5 to to IN cord-346964-9afuen7k 424 6 more more JJR cord-346964-9afuen7k 424 7 morphological morphological JJ cord-346964-9afuen7k 424 8 abnormalities abnormality NNS cord-346964-9afuen7k 424 9 in in IN cord-346964-9afuen7k 424 10 the the DT cord-346964-9afuen7k 424 11 form form NN cord-346964-9afuen7k 424 12 of of IN cord-346964-9afuen7k 424 13 villous villous JJ cord-346964-9afuen7k 424 14 blunting blunting NN cord-346964-9afuen7k 424 15 , , , cord-346964-9afuen7k 424 16 crypt crypt JJ cord-346964-9afuen7k 424 17 hyperplasia hyperplasia NN cord-346964-9afuen7k 424 18 , , , cord-346964-9afuen7k 424 19 and and CC cord-346964-9afuen7k 424 20 a a DT cord-346964-9afuen7k 424 21 mixed mixed JJ cord-346964-9afuen7k 424 22 inflammatory inflammatory JJ cord-346964-9afuen7k 424 23 infiltrate infiltrate NN cord-346964-9afuen7k 424 24 in in IN cord-346964-9afuen7k 424 25 the the DT cord-346964-9afuen7k 424 26 lamina lamina JJ cord-346964-9afuen7k 424 27 propria propria NN cord-346964-9afuen7k 424 28 , , , cord-346964-9afuen7k 424 29 predominantly predominantly RB cord-346964-9afuen7k 424 30 rich rich JJ cord-346964-9afuen7k 424 31 in in IN cord-346964-9afuen7k 424 32 eosinophils eosinophil NNS cord-346964-9afuen7k 424 33 . . . cord-346964-9afuen7k 425 1 The the DT cord-346964-9afuen7k 425 2 parasite parasite NN cord-346964-9afuen7k 425 3 is be VBZ cord-346964-9afuen7k 425 4 banana- banana- RB cord-346964-9afuen7k 425 5 shaped shape VBN cord-346964-9afuen7k 425 6 and and CC cord-346964-9afuen7k 425 7 can can MD cord-346964-9afuen7k 425 8 be be VB cord-346964-9afuen7k 425 9 found find VBN cord-346964-9afuen7k 425 10 in in IN cord-346964-9afuen7k 425 11 the the DT cord-346964-9afuen7k 425 12 cytoplasm cytoplasm NN cord-346964-9afuen7k 425 13 of of IN cord-346964-9afuen7k 425 14 the the DT cord-346964-9afuen7k 425 15 enterocyte enterocyte NN cord-346964-9afuen7k 425 16 ( ( -LRB- cord-346964-9afuen7k 425 17 Figure Figure NNP cord-346964-9afuen7k 425 18 22 22 CD cord-346964-9afuen7k 425 19 ) ) -RRB- cord-346964-9afuen7k 425 20 highlighted highlight VBN cord-346964-9afuen7k 425 21 by by IN cord-346964-9afuen7k 425 22 a a DT cord-346964-9afuen7k 425 23 Giemsa Giemsa NNP cord-346964-9afuen7k 425 24 stain stain NN cord-346964-9afuen7k 425 25 . . . cord-346964-9afuen7k 426 1 Although although IN cord-346964-9afuen7k 426 2 helminthic helminthic JJ cord-346964-9afuen7k 426 3 infections infection NNS cord-346964-9afuen7k 426 4 affect affect VBP cord-346964-9afuen7k 426 5 the the DT cord-346964-9afuen7k 426 6 entire entire JJ cord-346964-9afuen7k 426 7 GI GI NNP cord-346964-9afuen7k 426 8 tract tract NN cord-346964-9afuen7k 426 9 , , , cord-346964-9afuen7k 426 10 those those DT cord-346964-9afuen7k 426 11 that that WDT cord-346964-9afuen7k 426 12 predominantly predominantly RB cord-346964-9afuen7k 426 13 infect infect VBP cord-346964-9afuen7k 426 14 the the DT cord-346964-9afuen7k 426 15 small small JJ cord-346964-9afuen7k 426 16 bowel bowel NN cord-346964-9afuen7k 426 17 will will MD cord-346964-9afuen7k 426 18 be be VB cord-346964-9afuen7k 426 19 discussed discuss VBN cord-346964-9afuen7k 426 20 here here RB cord-346964-9afuen7k 426 21 . . . cord-346964-9afuen7k 427 1 Infection infection NN cord-346964-9afuen7k 427 2 with with IN cord-346964-9afuen7k 427 3 Ancylostoma Ancylostoma NNP cord-346964-9afuen7k 427 4 duodenale duodenale NNP cord-346964-9afuen7k 427 5 , , , cord-346964-9afuen7k 427 6 a a DT cord-346964-9afuen7k 427 7 hookworm hookworm NN cord-346964-9afuen7k 427 8 , , , cord-346964-9afuen7k 427 9 causes cause VBZ cord-346964-9afuen7k 427 10 chronic chronic JJ cord-346964-9afuen7k 427 11 blood blood NN cord-346964-9afuen7k 427 12 loss loss NN cord-346964-9afuen7k 427 13 and and CC cord-346964-9afuen7k 427 14 malabsorption malabsorption NN cord-346964-9afuen7k 427 15 and and CC cord-346964-9afuen7k 427 16 bloody bloody JJ cord-346964-9afuen7k 427 17 diarrhea diarrhea NN cord-346964-9afuen7k 427 18 leading lead VBG cord-346964-9afuen7k 427 19 to to IN cord-346964-9afuen7k 427 20 iron iron NN cord-346964-9afuen7k 427 21 deficiency deficiency NN cord-346964-9afuen7k 427 22 anemia anemia NN cord-346964-9afuen7k 427 23 . . . cord-346964-9afuen7k 428 1 Patients patient NNS cord-346964-9afuen7k 428 2 often often RB cord-346964-9afuen7k 428 3 have have VBP cord-346964-9afuen7k 428 4 peripheral peripheral JJ cord-346964-9afuen7k 428 5 eosinophilia eosinophilia NN cord-346964-9afuen7k 428 6 with with IN cord-346964-9afuen7k 428 7 mucosal mucosal JJ cord-346964-9afuen7k 428 8 eosinophilic eosinophilic JJ cord-346964-9afuen7k 428 9 infiltrates infiltrate NNS cord-346964-9afuen7k 428 10 . . . cord-346964-9afuen7k 429 1 Mucosal Mucosal NNP cord-346964-9afuen7k 429 2 ulcerations ulceration NNS cord-346964-9afuen7k 429 3 are be VBP cord-346964-9afuen7k 429 4 common common JJ cord-346964-9afuen7k 429 5 when when WRB cord-346964-9afuen7k 429 6 there there EX cord-346964-9afuen7k 429 7 is be VBZ cord-346964-9afuen7k 429 8 heavy heavy JJ cord-346964-9afuen7k 429 9 parasitic parasitic JJ cord-346964-9afuen7k 429 10 infection infection NN cord-346964-9afuen7k 429 11 . . . cord-346964-9afuen7k 430 1 Strongyloides Strongyloides NNP cord-346964-9afuen7k 430 2 stercoralis stercoralis NNP cord-346964-9afuen7k 430 3 also also RB cord-346964-9afuen7k 430 4 causes cause VBZ cord-346964-9afuen7k 430 5 malabsorption malabsorption NN cord-346964-9afuen7k 430 6 , , , cord-346964-9afuen7k 430 7 diarrhea diarrhea NN cord-346964-9afuen7k 430 8 , , , cord-346964-9afuen7k 430 9 and and CC cord-346964-9afuen7k 430 10 eosinophilia eosinophilia NN cord-346964-9afuen7k 430 11 . . . cord-346964-9afuen7k 431 1 The the DT cord-346964-9afuen7k 431 2 intestinal intestinal JJ cord-346964-9afuen7k 431 3 surface surface NN cord-346964-9afuen7k 431 4 is be VBZ cord-346964-9afuen7k 431 5 hemorrhagic hemorrhagic JJ cord-346964-9afuen7k 431 6 and and CC cord-346964-9afuen7k 431 7 eroded erode VBN cord-346964-9afuen7k 431 8 covered cover VBN cord-346964-9afuen7k 431 9 with with IN cord-346964-9afuen7k 431 10 a a DT cord-346964-9afuen7k 431 11 pseudomembrane pseudomembrane NN cord-346964-9afuen7k 431 12 of of IN cord-346964-9afuen7k 431 13 exudate exudate NN cord-346964-9afuen7k 431 14 and and CC cord-346964-9afuen7k 431 15 fibrin fibrin NN cord-346964-9afuen7k 431 16 . . . cord-346964-9afuen7k 432 1 Larvae larvae NN cord-346964-9afuen7k 432 2 , , , cord-346964-9afuen7k 432 3 adult adult NN cord-346964-9afuen7k 432 4 forms form NNS cord-346964-9afuen7k 432 5 , , , cord-346964-9afuen7k 432 6 and and CC cord-346964-9afuen7k 432 7 eggs egg NNS cord-346964-9afuen7k 432 8 may may MD cord-346964-9afuen7k 432 9 all all DT cord-346964-9afuen7k 432 10 be be VB cord-346964-9afuen7k 432 11 present present JJ cord-346964-9afuen7k 432 12 within within IN cord-346964-9afuen7k 432 13 the the DT cord-346964-9afuen7k 432 14 crypts crypt NNS cord-346964-9afuen7k 432 15 ( ( -LRB- cord-346964-9afuen7k 432 16 Figure figure NN cord-346964-9afuen7k 432 17 23 23 CD cord-346964-9afuen7k 432 18 ) ) -RRB- cord-346964-9afuen7k 432 19 . . . cord-346964-9afuen7k 433 1 Fasciolopsis Fasciolopsis NNP cord-346964-9afuen7k 433 2 buski buski NNP cord-346964-9afuen7k 433 3 inhabits inhabit VBZ cord-346964-9afuen7k 433 4 the the DT cord-346964-9afuen7k 433 5 upper upper JJ cord-346964-9afuen7k 433 6 small small JJ cord-346964-9afuen7k 433 7 intestine intestine NN cord-346964-9afuen7k 433 8 . . . cord-346964-9afuen7k 434 1 The the DT cord-346964-9afuen7k 434 2 infection infection NN cord-346964-9afuen7k 434 3 is be VBZ cord-346964-9afuen7k 434 4 usually usually RB cord-346964-9afuen7k 434 5 asymptomatic asymptomatic JJ cord-346964-9afuen7k 434 6 unless unless IN cord-346964-9afuen7k 434 7 there there EX cord-346964-9afuen7k 434 8 is be VBZ cord-346964-9afuen7k 434 9 heavy heavy JJ cord-346964-9afuen7k 434 10 parasitic parasitic JJ cord-346964-9afuen7k 434 11 infection infection NN cord-346964-9afuen7k 434 12 . . . cord-346964-9afuen7k 435 1 Symptoms symptom NNS cord-346964-9afuen7k 435 2 include include VBP cord-346964-9afuen7k 435 3 nausea nausea NN cord-346964-9afuen7k 435 4 , , , cord-346964-9afuen7k 435 5 diarrhea diarrhea NN cord-346964-9afuen7k 435 6 , , , cord-346964-9afuen7k 435 7 and and CC cord-346964-9afuen7k 435 8 GI GI NNP cord-346964-9afuen7k 435 9 hemorrhage hemorrhage NN cord-346964-9afuen7k 435 10 . . . cord-346964-9afuen7k 436 1 Large large JJ cord-346964-9afuen7k 436 2 adult adult NN cord-346964-9afuen7k 436 3 parasites parasite NNS cord-346964-9afuen7k 436 4 attach attach VBP cord-346964-9afuen7k 436 5 to to IN cord-346964-9afuen7k 436 6 the the DT cord-346964-9afuen7k 436 7 intestinal intestinal JJ cord-346964-9afuen7k 436 8 mucosa mucosa NN cord-346964-9afuen7k 436 9 inciting incite VBG cord-346964-9afuen7k 436 10 an an DT cord-346964-9afuen7k 436 11 inflammatory inflammatory JJ cord-346964-9afuen7k 436 12 reaction reaction NN cord-346964-9afuen7k 436 13 . . . cord-346964-9afuen7k 437 1 Biopsies biopsy NNS cord-346964-9afuen7k 437 2 from from IN cord-346964-9afuen7k 437 3 patients patient NNS cord-346964-9afuen7k 437 4 with with IN cord-346964-9afuen7k 437 5 enteric enteric JJ cord-346964-9afuen7k 437 6 viral viral JJ cord-346964-9afuen7k 437 7 infections infection NNS cord-346964-9afuen7k 437 8 seldom seldom RB cord-346964-9afuen7k 437 9 if if IN cord-346964-9afuen7k 437 10 ever ever RB cord-346964-9afuen7k 437 11 cross cross VBP cord-346964-9afuen7k 437 12 the the DT cord-346964-9afuen7k 437 13 stage stage NN cord-346964-9afuen7k 437 14 of of IN cord-346964-9afuen7k 437 15 the the DT cord-346964-9afuen7k 437 16 surgical surgical JJ cord-346964-9afuen7k 437 17 pathologist pathologist NN cord-346964-9afuen7k 437 18 , , , cord-346964-9afuen7k 437 19 as as IN cord-346964-9afuen7k 437 20 they -PRON- PRP cord-346964-9afuen7k 437 21 are be VBP cord-346964-9afuen7k 437 22 detected detect VBN cord-346964-9afuen7k 437 23 in in IN cord-346964-9afuen7k 437 24 stool stool NN cord-346964-9afuen7k 437 25 samples sample NNS cord-346964-9afuen7k 437 26 rather rather RB cord-346964-9afuen7k 437 27 than than IN cord-346964-9afuen7k 437 28 biopsy biopsy NN cord-346964-9afuen7k 437 29 specimens specimen NNS cord-346964-9afuen7k 437 30 . . . cord-346964-9afuen7k 438 1 Some some DT cord-346964-9afuen7k 438 2 common common JJ cord-346964-9afuen7k 438 3 enteric enteric JJ cord-346964-9afuen7k 438 4 viruses virus NNS cord-346964-9afuen7k 438 5 known know VBN cord-346964-9afuen7k 438 6 to to TO cord-346964-9afuen7k 438 7 cause cause VB cord-346964-9afuen7k 438 8 diarrhea diarrhea NN cord-346964-9afuen7k 438 9 include include VB cord-346964-9afuen7k 438 10 , , , cord-346964-9afuen7k 438 11 adenovirus adenovirus NN cord-346964-9afuen7k 438 12 , , , cord-346964-9afuen7k 438 13 rotavirus rotavirus NN cord-346964-9afuen7k 438 14 , , , cord-346964-9afuen7k 438 15 coronavirus coronavirus NN cord-346964-9afuen7k 438 16 , , , cord-346964-9afuen7k 438 17 echovirus echovirus NNP cord-346964-9afuen7k 438 18 , , , cord-346964-9afuen7k 438 19 enterovirus enterovirus NN cord-346964-9afuen7k 438 20 , , , cord-346964-9afuen7k 438 21 astrovirus astrovirus NNP cord-346964-9afuen7k 438 22 , , , cord-346964-9afuen7k 438 23 and and CC cord-346964-9afuen7k 438 24 Norwalk Norwalk NNP cord-346964-9afuen7k 438 25 virus virus NN cord-346964-9afuen7k 438 26 . . . cord-346964-9afuen7k 439 1 Rotavirus rotavirus NN cord-346964-9afuen7k 439 2 is be VBZ cord-346964-9afuen7k 439 3 the the DT cord-346964-9afuen7k 439 4 most most RBS cord-346964-9afuen7k 439 5 common common JJ cord-346964-9afuen7k 439 6 cause cause NN cord-346964-9afuen7k 439 7 of of IN cord-346964-9afuen7k 439 8 severe severe JJ cord-346964-9afuen7k 439 9 childhood childhood NN cord-346964-9afuen7k 439 10 diarrhea diarrhea NN cord-346964-9afuen7k 439 11 and and CC cord-346964-9afuen7k 439 12 diarrheal diarrheal JJ cord-346964-9afuen7k 439 13 mortality mortality NN cord-346964-9afuen7k 439 14 worldwide worldwide RB cord-346964-9afuen7k 439 15 , , , cord-346964-9afuen7k 439 16 particularly particularly RB cord-346964-9afuen7k 439 17 in in IN cord-346964-9afuen7k 439 18 children child NNS cord-346964-9afuen7k 439 19 under under IN cord-346964-9afuen7k 439 20 the the DT cord-346964-9afuen7k 439 21 age age NN cord-346964-9afuen7k 439 22 of of IN cord-346964-9afuen7k 439 23 2 2 CD cord-346964-9afuen7k 439 24 years year NNS cord-346964-9afuen7k 439 25 . . . cord-346964-9afuen7k 440 1 Patients patient NNS cord-346964-9afuen7k 440 2 develop develop VBP cord-346964-9afuen7k 440 3 fever fever NN cord-346964-9afuen7k 440 4 , , , cord-346964-9afuen7k 440 5 severe severe JJ cord-346964-9afuen7k 440 6 watery watery JJ cord-346964-9afuen7k 440 7 diarrhea diarrhea NN cord-346964-9afuen7k 440 8 , , , cord-346964-9afuen7k 440 9 and and CC cord-346964-9afuen7k 440 10 vomiting vomit VBG cord-346964-9afuen7k 440 11 leading lead VBG cord-346964-9afuen7k 440 12 to to IN cord-346964-9afuen7k 440 13 dehydration dehydration NN cord-346964-9afuen7k 440 14 and and CC cord-346964-9afuen7k 440 15 acidosis acidosis NN cord-346964-9afuen7k 440 16 . . . cord-346964-9afuen7k 441 1 Biopsy biopsy JJ cord-346964-9afuen7k 441 2 changes change NNS cord-346964-9afuen7k 441 3 are be VBP cord-346964-9afuen7k 441 4 very very RB cord-346964-9afuen7k 441 5 nonspecific nonspecific JJ cord-346964-9afuen7k 441 6 and and CC cord-346964-9afuen7k 441 7 include include VBP cord-346964-9afuen7k 441 8 increased increase VBN cord-346964-9afuen7k 441 9 inflammatory inflammatory JJ cord-346964-9afuen7k 441 10 cells cell NNS cord-346964-9afuen7k 441 11 in in IN cord-346964-9afuen7k 441 12 the the DT cord-346964-9afuen7k 441 13 lamina lamina JJ cord-346964-9afuen7k 441 14 propria propria NN cord-346964-9afuen7k 441 15 , , , cord-346964-9afuen7k 441 16 degenerative degenerative JJ cord-346964-9afuen7k 441 17 epithelial epithelial JJ cord-346964-9afuen7k 441 18 changes change NNS cord-346964-9afuen7k 441 19 , , , cord-346964-9afuen7k 441 20 and and CC cord-346964-9afuen7k 441 21 widening widening NN cord-346964-9afuen7k 441 22 of of IN cord-346964-9afuen7k 441 23 villous villous NN cord-346964-9afuen7k 441 24 tips tip NNS cord-346964-9afuen7k 441 25 . . . cord-346964-9afuen7k 442 1 The the DT cord-346964-9afuen7k 442 2 diagnosis diagnosis NN cord-346964-9afuen7k 442 3 of of IN cord-346964-9afuen7k 442 4 rotavirus rotavirus NN cord-346964-9afuen7k 442 5 is be VBZ cord-346964-9afuen7k 442 6 generally generally RB cord-346964-9afuen7k 442 7 made make VBN cord-346964-9afuen7k 442 8 by by IN cord-346964-9afuen7k 442 9 stool stool NN cord-346964-9afuen7k 442 10 immunoassay immunoassay NN cord-346964-9afuen7k 442 11 and/or and/or CC cord-346964-9afuen7k 442 12 culture culture NN cord-346964-9afuen7k 442 13 , , , cord-346964-9afuen7k 442 14 and and CC cord-346964-9afuen7k 442 15 the the DT cord-346964-9afuen7k 442 16 disease disease NN cord-346964-9afuen7k 442 17 is be VBZ cord-346964-9afuen7k 442 18 rarely rarely RB cord-346964-9afuen7k 442 19 biopsied biopsie VBN cord-346964-9afuen7k 442 20 . . . cord-346964-9afuen7k 443 1 Adenovirus Adenovirus NNP cord-346964-9afuen7k 443 2 infection infection NN cord-346964-9afuen7k 443 3 is be VBZ cord-346964-9afuen7k 443 4 also also RB cord-346964-9afuen7k 443 5 frequent frequent JJ cord-346964-9afuen7k 443 6 as as IN cord-346964-9afuen7k 443 7 a a DT cord-346964-9afuen7k 443 8 cause cause NN cord-346964-9afuen7k 443 9 of of IN cord-346964-9afuen7k 443 10 childhood childhood NN cord-346964-9afuen7k 443 11 diarrhea diarrhea NN cord-346964-9afuen7k 443 12 . . . cord-346964-9afuen7k 444 1 However however RB cord-346964-9afuen7k 444 2 , , , cord-346964-9afuen7k 444 3 it -PRON- PRP cord-346964-9afuen7k 444 4 may may MD cord-346964-9afuen7k 444 5 also also RB cord-346964-9afuen7k 444 6 cause cause VB cord-346964-9afuen7k 444 7 diarrhea diarrhea NN cord-346964-9afuen7k 444 8 in in IN cord-346964-9afuen7k 444 9 immunocompromised immunocompromised JJ cord-346964-9afuen7k 444 10 patients patient NNS cord-346964-9afuen7k 444 11 , , , cord-346964-9afuen7k 444 12 especially especially RB cord-346964-9afuen7k 444 13 those those DT cord-346964-9afuen7k 444 14 with with IN cord-346964-9afuen7k 444 15 human human JJ cord-346964-9afuen7k 444 16 immunodeficiency immunodeficiency NN cord-346964-9afuen7k 444 17 virus virus NN cord-346964-9afuen7k 444 18 ( ( -LRB- cord-346964-9afuen7k 444 19 HIV HIV NNP cord-346964-9afuen7k 444 20 ) ) -RRB- cord-346964-9afuen7k 444 21 and and CC cord-346964-9afuen7k 444 22 AIDS AIDS NNP cord-346964-9afuen7k 444 23 . . . cord-346964-9afuen7k 445 1 Histological histological JJ cord-346964-9afuen7k 445 2 features feature NNS cord-346964-9afuen7k 445 3 of of IN cord-346964-9afuen7k 445 4 adenovirus adenovirus NN cord-346964-9afuen7k 445 5 infection infection NN cord-346964-9afuen7k 445 6 include include VBP cord-346964-9afuen7k 445 7 epithelial epithelial JJ cord-346964-9afuen7k 445 8 cellular cellular JJ cord-346964-9afuen7k 445 9 changes change NNS cord-346964-9afuen7k 445 10 such such JJ cord-346964-9afuen7k 445 11 as as IN cord-346964-9afuen7k 445 12 loss loss NN cord-346964-9afuen7k 445 13 of of IN cord-346964-9afuen7k 445 14 maturation maturation NN cord-346964-9afuen7k 445 15 , , , cord-346964-9afuen7k 445 16 disorganization disorganization NN cord-346964-9afuen7k 445 17 , , , cord-346964-9afuen7k 445 18 and and CC cord-346964-9afuen7k 445 19 degeneration degeneration NN cord-346964-9afuen7k 445 20 . . . cord-346964-9afuen7k 446 1 Characteristic characteristic JJ cord-346964-9afuen7k 446 2 inclusions inclusion NNS cord-346964-9afuen7k 446 3 usually usually RB cord-346964-9afuen7k 446 4 crescent crescent NN cord-346964-9afuen7k 446 5 - - HYPH cord-346964-9afuen7k 446 6 shaped shape VBN cord-346964-9afuen7k 446 7 may may MD cord-346964-9afuen7k 446 8 be be VB cord-346964-9afuen7k 446 9 seen see VBN cord-346964-9afuen7k 446 10 , , , cord-346964-9afuen7k 446 11 especially especially RB cord-346964-9afuen7k 446 12 in in IN cord-346964-9afuen7k 446 13 immunocompromised immunocompromised JJ cord-346964-9afuen7k 446 14 patients patient NNS cord-346964-9afuen7k 446 15 , , , cord-346964-9afuen7k 446 16 within within IN cord-346964-9afuen7k 446 17 the the DT cord-346964-9afuen7k 446 18 nuclei nucleus NNS cord-346964-9afuen7k 446 19 of of IN cord-346964-9afuen7k 446 20 surface surface NN cord-346964-9afuen7k 446 21 epithelium epithelium NN cord-346964-9afuen7k 446 22 ( ( -LRB- cord-346964-9afuen7k 446 23 particularly particularly RB cord-346964-9afuen7k 446 24 goblet goblet NN cord-346964-9afuen7k 446 25 cells cell NNS cord-346964-9afuen7k 446 26 ) ) -RRB- cord-346964-9afuen7k 446 27 . . . cord-346964-9afuen7k 447 1 Useful useful JJ cord-346964-9afuen7k 447 2 aids aid NNS cord-346964-9afuen7k 447 3 to to IN cord-346964-9afuen7k 447 4 diagnosis diagnosis NN cord-346964-9afuen7k 447 5 of of IN cord-346964-9afuen7k 447 6 adenovirus adenovirus NN cord-346964-9afuen7k 447 7 infection infection NN cord-346964-9afuen7k 447 8 include include VBP cord-346964-9afuen7k 447 9 immunohistochemistry immunohistochemistry NN cord-346964-9afuen7k 447 10 , , , cord-346964-9afuen7k 447 11 stool stool NN cord-346964-9afuen7k 447 12 examination examination NN cord-346964-9afuen7k 447 13 by by IN cord-346964-9afuen7k 447 14 electron electron NN cord-346964-9afuen7k 447 15 microscopy microscopy NN cord-346964-9afuen7k 447 16 , , , cord-346964-9afuen7k 447 17 and and CC cord-346964-9afuen7k 447 18 viral viral JJ cord-346964-9afuen7k 447 19 culture culture NN cord-346964-9afuen7k 447 20 . . . cord-346964-9afuen7k 448 1 Pathologists pathologist NNS cord-346964-9afuen7k 448 2 usually usually RB cord-346964-9afuen7k 448 3 get get VBP cord-346964-9afuen7k 448 4 a a DT cord-346964-9afuen7k 448 5 specimen specimen NN cord-346964-9afuen7k 448 6 from from IN cord-346964-9afuen7k 448 7 adenovirusinfected adenovirusinfecte VBN cord-346964-9afuen7k 448 8 patients patient NNS cord-346964-9afuen7k 448 9 when when WRB cord-346964-9afuen7k 448 10 the the DT cord-346964-9afuen7k 448 11 patient patient NN cord-346964-9afuen7k 448 12 develops develop VBZ cord-346964-9afuen7k 448 13 intussusception intussusception NN cord-346964-9afuen7k 448 14 . . . cord-346964-9afuen7k 449 1 CMV CMV NNP cord-346964-9afuen7k 449 2 infection infection NN cord-346964-9afuen7k 449 3 may may MD cord-346964-9afuen7k 449 4 be be VB cord-346964-9afuen7k 449 5 diagnosed diagnose VBN cord-346964-9afuen7k 449 6 in in IN cord-346964-9afuen7k 449 7 patients patient NNS cord-346964-9afuen7k 449 8 with with IN cord-346964-9afuen7k 449 9 immunosuppression immunosuppression NN cord-346964-9afuen7k 449 10 or or CC cord-346964-9afuen7k 449 11 IBD IBD NNP cord-346964-9afuen7k 449 12 even even RB cord-346964-9afuen7k 449 13 when when WRB cord-346964-9afuen7k 449 14 the the DT cord-346964-9afuen7k 449 15 patients patient NNS cord-346964-9afuen7k 449 16 have have VBP cord-346964-9afuen7k 449 17 not not RB cord-346964-9afuen7k 449 18 been be VBN cord-346964-9afuen7k 449 19 treated treat VBN cord-346964-9afuen7k 449 20 with with IN cord-346964-9afuen7k 449 21 steroids steroid NNS cord-346964-9afuen7k 449 22 . . . cord-346964-9afuen7k 450 1 It -PRON- PRP cord-346964-9afuen7k 450 2 is be VBZ cord-346964-9afuen7k 450 3 particularly particularly RB cord-346964-9afuen7k 450 4 important important JJ cord-346964-9afuen7k 450 5 to to TO cord-346964-9afuen7k 450 6 consider consider VB cord-346964-9afuen7k 450 7 this this DT cord-346964-9afuen7k 450 8 diagnosis diagnosis NN cord-346964-9afuen7k 450 9 in in IN cord-346964-9afuen7k 450 10 patients patient NNS cord-346964-9afuen7k 450 11 with with IN cord-346964-9afuen7k 450 12 steroid steroid JJ cord-346964-9afuen7k 450 13 - - HYPH cord-346964-9afuen7k 450 14 resistant resistant JJ cord-346964-9afuen7k 450 15 disease disease NN cord-346964-9afuen7k 450 16 as as IN cord-346964-9afuen7k 450 17 treating treat VBG cord-346964-9afuen7k 450 18 the the DT cord-346964-9afuen7k 450 19 CMV CMV NNP cord-346964-9afuen7k 450 20 may may MD cord-346964-9afuen7k 450 21 prevent prevent VB cord-346964-9afuen7k 450 22 the the DT cord-346964-9afuen7k 450 23 need need NN cord-346964-9afuen7k 450 24 for for IN cord-346964-9afuen7k 450 25 other other JJ cord-346964-9afuen7k 450 26 medical medical JJ cord-346964-9afuen7k 450 27 therapy therapy NN cord-346964-9afuen7k 450 28 or or CC cord-346964-9afuen7k 450 29 surgery surgery NN cord-346964-9afuen7k 450 30 . . . cord-346964-9afuen7k 451 1 Symptoms symptom NNS cord-346964-9afuen7k 451 2 may may MD cord-346964-9afuen7k 451 3 vary vary VB cord-346964-9afuen7k 451 4 with with IN cord-346964-9afuen7k 451 5 the the DT cord-346964-9afuen7k 451 6 immune immune JJ cord-346964-9afuen7k 451 7 status status NN cord-346964-9afuen7k 451 8 of of IN cord-346964-9afuen7k 451 9 the the DT cord-346964-9afuen7k 451 10 patients patient NNS cord-346964-9afuen7k 451 11 and and CC cord-346964-9afuen7k 451 12 the the DT cord-346964-9afuen7k 451 13 site site NN cord-346964-9afuen7k 451 14 of of IN cord-346964-9afuen7k 451 15 the the DT cord-346964-9afuen7k 451 16 infection infection NN cord-346964-9afuen7k 451 17 . . . cord-346964-9afuen7k 452 1 Most most RBS cord-346964-9afuen7k 452 2 commonly commonly RB cord-346964-9afuen7k 452 3 abdominal abdominal JJ cord-346964-9afuen7k 452 4 pain pain NN cord-346964-9afuen7k 452 5 , , , cord-346964-9afuen7k 452 6 diarrhea diarrhea NN cord-346964-9afuen7k 452 7 , , , cord-346964-9afuen7k 452 8 fever fever NN cord-346964-9afuen7k 452 9 , , , cord-346964-9afuen7k 452 10 and and CC cord-346964-9afuen7k 452 11 weight weight NN cord-346964-9afuen7k 452 12 loss loss NN cord-346964-9afuen7k 452 13 are be VBP cord-346964-9afuen7k 452 14 observed observe VBN cord-346964-9afuen7k 452 15 , , , cord-346964-9afuen7k 452 16 while while IN cord-346964-9afuen7k 452 17 isolated isolate VBN cord-346964-9afuen7k 452 18 CMV CMV NNP cord-346964-9afuen7k 452 19 infection infection NN cord-346964-9afuen7k 452 20 of of IN cord-346964-9afuen7k 452 21 the the DT cord-346964-9afuen7k 452 22 duodenum duodenum NN cord-346964-9afuen7k 452 23 may may MD cord-346964-9afuen7k 452 24 lead lead VB cord-346964-9afuen7k 452 25 to to IN cord-346964-9afuen7k 452 26 severe severe JJ cord-346964-9afuen7k 452 27 GI gi NN cord-346964-9afuen7k 452 28 bleeding bleeding NN cord-346964-9afuen7k 452 29 . . . cord-346964-9afuen7k 453 1 It -PRON- PRP cord-346964-9afuen7k 453 2 usually usually RB cord-346964-9afuen7k 453 3 causes cause VBZ cord-346964-9afuen7k 453 4 ulceration ulceration NN cord-346964-9afuen7k 453 5 of of IN cord-346964-9afuen7k 453 6 the the DT cord-346964-9afuen7k 453 7 mucosa mucosa NN cord-346964-9afuen7k 453 8 and and CC cord-346964-9afuen7k 453 9 the the DT cord-346964-9afuen7k 453 10 viral viral JJ cord-346964-9afuen7k 453 11 inclusions inclusion NNS cord-346964-9afuen7k 453 12 are be VBP cord-346964-9afuen7k 453 13 frequently frequently RB cord-346964-9afuen7k 453 14 found find VBN cord-346964-9afuen7k 453 15 at at IN cord-346964-9afuen7k 453 16 the the DT cord-346964-9afuen7k 453 17 ulcer ulcer NN cord-346964-9afuen7k 453 18 base base NN cord-346964-9afuen7k 453 19 . . . cord-346964-9afuen7k 454 1 The the DT cord-346964-9afuen7k 454 2 characteristic characteristic JJ cord-346964-9afuen7k 454 3 owl owl NN cord-346964-9afuen7k 454 4 's 's POS cord-346964-9afuen7k 454 5 eye eye NN cord-346964-9afuen7k 454 6 inclusions inclusion NNS cord-346964-9afuen7k 454 7 are be VBP cord-346964-9afuen7k 454 8 preferentially preferentially RB cord-346964-9afuen7k 454 9 found find VBN cord-346964-9afuen7k 454 10 in in IN cord-346964-9afuen7k 454 11 endothelial endothelial JJ cord-346964-9afuen7k 454 12 cells cell NNS cord-346964-9afuen7k 454 13 and and CC cord-346964-9afuen7k 454 14 stromal stromal JJ cord-346964-9afuen7k 454 15 cells cell NNS cord-346964-9afuen7k 454 16 but but CC cord-346964-9afuen7k 454 17 only only RB cord-346964-9afuen7k 454 18 rarely rarely RB cord-346964-9afuen7k 454 19 in in IN cord-346964-9afuen7k 454 20 enterocytes enterocyte NNS cord-346964-9afuen7k 454 21 ( ( -LRB- cord-346964-9afuen7k 454 22 Figure figure NN cord-346964-9afuen7k 454 23 24(a)-24(c 24(a)-24(c CD cord-346964-9afuen7k 454 24 ) ) -RRB- cord-346964-9afuen7k 454 25 ) ) -RRB- cord-346964-9afuen7k 454 26 . . . cord-346964-9afuen7k 455 1 Though though IN cord-346964-9afuen7k 455 2 H&E H&E NNP cord-346964-9afuen7k 455 3 sections section NNS cord-346964-9afuen7k 455 4 are be VBP cord-346964-9afuen7k 455 5 diagnostic diagnostic JJ cord-346964-9afuen7k 455 6 , , , cord-346964-9afuen7k 455 7 immunohistochemistry immunohistochemistry NN cord-346964-9afuen7k 455 8 may may MD cord-346964-9afuen7k 455 9 be be VB cord-346964-9afuen7k 455 10 applied apply VBN cord-346964-9afuen7k 455 11 when when WRB cord-346964-9afuen7k 455 12 in in IN cord-346964-9afuen7k 455 13 doubt doubt NN cord-346964-9afuen7k 455 14 . . . cord-346964-9afuen7k 456 1 CMV CMV NNP cord-346964-9afuen7k 456 2 infection infection NN cord-346964-9afuen7k 456 3 may may MD cord-346964-9afuen7k 456 4 mimic mimic VB cord-346964-9afuen7k 456 5 IBD IBD NNP cord-346964-9afuen7k 456 6 both both DT cord-346964-9afuen7k 456 7 clinically clinically RB cord-346964-9afuen7k 456 8 and and CC cord-346964-9afuen7k 456 9 histologically histologically RB cord-346964-9afuen7k 456 10 . . . cord-346964-9afuen7k 457 1 Diarrhea diarrhea NN cord-346964-9afuen7k 457 2 in in IN cord-346964-9afuen7k 457 3 the the DT cord-346964-9afuen7k 457 4 setting setting NN cord-346964-9afuen7k 457 5 of of IN cord-346964-9afuen7k 457 6 HIV HIV NNP cord-346964-9afuen7k 457 7 infection infection NN cord-346964-9afuen7k 457 8 may may MD cord-346964-9afuen7k 457 9 be be VB cord-346964-9afuen7k 457 10 related relate VBN cord-346964-9afuen7k 457 11 either either CC cord-346964-9afuen7k 457 12 to to IN cord-346964-9afuen7k 457 13 the the DT cord-346964-9afuen7k 457 14 infection infection NN cord-346964-9afuen7k 457 15 itself -PRON- PRP cord-346964-9afuen7k 457 16 , , , cord-346964-9afuen7k 457 17 to to IN cord-346964-9afuen7k 457 18 the the DT cord-346964-9afuen7k 457 19 treatment treatment NN cord-346964-9afuen7k 457 20 , , , cord-346964-9afuen7k 457 21 or or CC cord-346964-9afuen7k 457 22 to to IN cord-346964-9afuen7k 457 23 the the DT cord-346964-9afuen7k 457 24 opportunistic opportunistic JJ cord-346964-9afuen7k 457 25 infections infection NNS cord-346964-9afuen7k 457 26 . . . cord-346964-9afuen7k 458 1 Gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 458 2 complications complication NNS cord-346964-9afuen7k 458 3 of of IN cord-346964-9afuen7k 458 4 HIV HIV NNP cord-346964-9afuen7k 458 5 infection infection NN cord-346964-9afuen7k 458 6 have have VBP cord-346964-9afuen7k 458 7 dramatically dramatically RB cord-346964-9afuen7k 458 8 decreased decrease VBN cord-346964-9afuen7k 458 9 after after IN cord-346964-9afuen7k 458 10 the the DT cord-346964-9afuen7k 458 11 introduction introduction NN cord-346964-9afuen7k 458 12 of of IN cord-346964-9afuen7k 458 13 HAART HAART NNP cord-346964-9afuen7k 458 14 protocols protocol NNS cord-346964-9afuen7k 458 15 . . . cord-346964-9afuen7k 459 1 However however RB cord-346964-9afuen7k 459 2 , , , cord-346964-9afuen7k 459 3 the the DT cord-346964-9afuen7k 459 4 effects effect NNS cord-346964-9afuen7k 459 5 of of IN cord-346964-9afuen7k 459 6 antiviral antiviral JJ cord-346964-9afuen7k 459 7 drugs drug NNS cord-346964-9afuen7k 459 8 on on IN cord-346964-9afuen7k 459 9 the the DT cord-346964-9afuen7k 459 10 GI GI NNP cord-346964-9afuen7k 459 11 tract tract NN cord-346964-9afuen7k 459 12 together together RB cord-346964-9afuen7k 459 13 with with IN cord-346964-9afuen7k 459 14 superimposed superimpose VBN cord-346964-9afuen7k 459 15 infections infection NNS cord-346964-9afuen7k 459 16 are be VBP cord-346964-9afuen7k 459 17 still still RB cord-346964-9afuen7k 459 18 commonly commonly RB cord-346964-9afuen7k 459 19 seen see VBN cord-346964-9afuen7k 459 20 in in IN cord-346964-9afuen7k 459 21 these these DT cord-346964-9afuen7k 459 22 patients patient NNS cord-346964-9afuen7k 459 23 , , , cord-346964-9afuen7k 459 24 especially especially RB cord-346964-9afuen7k 459 25 in in IN cord-346964-9afuen7k 459 26 those those DT cord-346964-9afuen7k 459 27 with with IN cord-346964-9afuen7k 459 28 sustained sustained JJ cord-346964-9afuen7k 459 29 low low JJ cord-346964-9afuen7k 459 30 levels level NNS cord-346964-9afuen7k 459 31 of of IN cord-346964-9afuen7k 459 32 CD4 CD4 NNP cord-346964-9afuen7k 459 33 þ þ NNP cord-346964-9afuen7k 459 34 T t NN cord-346964-9afuen7k 459 35 - - HYPH cord-346964-9afuen7k 459 36 cell cell NN cord-346964-9afuen7k 459 37 counts count NNS cord-346964-9afuen7k 459 38 . . . cord-346964-9afuen7k 460 1 Also also RB cord-346964-9afuen7k 460 2 , , , cord-346964-9afuen7k 460 3 these these DT cord-346964-9afuen7k 460 4 patients patient NNS cord-346964-9afuen7k 460 5 may may MD cord-346964-9afuen7k 460 6 have have VB cord-346964-9afuen7k 460 7 atypical atypical JJ cord-346964-9afuen7k 460 8 presentations presentation NNS cord-346964-9afuen7k 460 9 of of IN cord-346964-9afuen7k 460 10 opportunistic opportunistic JJ cord-346964-9afuen7k 460 11 infections infection NNS cord-346964-9afuen7k 460 12 that that WDT cord-346964-9afuen7k 460 13 occur occur VBP cord-346964-9afuen7k 460 14 during during IN cord-346964-9afuen7k 460 15 or or CC cord-346964-9afuen7k 460 16 after after IN cord-346964-9afuen7k 460 17 therapy therapy NN cord-346964-9afuen7k 460 18 . . . cord-346964-9afuen7k 461 1 Hence hence RB cord-346964-9afuen7k 461 2 , , , cord-346964-9afuen7k 461 3 a a DT cord-346964-9afuen7k 461 4 CD4 CD4 NNP cord-346964-9afuen7k 461 5 count count VB cord-346964-9afuen7k 461 6 < < XX cord-346964-9afuen7k 461 7 200 200 CD cord-346964-9afuen7k 461 8 cells cell NNS cord-346964-9afuen7k 462 1 mm mm NNP cord-346964-9afuen7k 462 2 À3 À3 NNP cord-346964-9afuen7k 462 3 is be VBZ cord-346964-9afuen7k 462 4 the the DT cord-346964-9afuen7k 462 5 marker marker NN cord-346964-9afuen7k 462 6 for for IN cord-346964-9afuen7k 462 7 those those DT cord-346964-9afuen7k 462 8 patients patient NNS cord-346964-9afuen7k 462 9 who who WP cord-346964-9afuen7k 462 10 should should MD cord-346964-9afuen7k 462 11 be be VB cord-346964-9afuen7k 462 12 searched search VBN cord-346964-9afuen7k 462 13 for for IN cord-346964-9afuen7k 462 14 opportunistic opportunistic JJ cord-346964-9afuen7k 462 15 infections infection NNS cord-346964-9afuen7k 462 16 for for IN cord-346964-9afuen7k 462 17 their -PRON- PRP$ cord-346964-9afuen7k 462 18 GI GI NNP cord-346964-9afuen7k 462 19 symptoms symptom NNS cord-346964-9afuen7k 462 20 . . . cord-346964-9afuen7k 463 1 Histological histological JJ cord-346964-9afuen7k 463 2 features feature NNS cord-346964-9afuen7k 463 3 of of IN cord-346964-9afuen7k 463 4 ' ' `` cord-346964-9afuen7k 463 5 HIV HIV NNP cord-346964-9afuen7k 463 6 enteropathy enteropathy NNP cord-346964-9afuen7k 463 7 ' ' '' cord-346964-9afuen7k 463 8 include include VBP cord-346964-9afuen7k 463 9 crypt crypt NN cord-346964-9afuen7k 463 10 hypertrophy hypertrophy NN cord-346964-9afuen7k 463 11 , , , cord-346964-9afuen7k 463 12 increased increase VBN cord-346964-9afuen7k 463 13 apoptosis apoptosis NN cord-346964-9afuen7k 463 14 in in IN cord-346964-9afuen7k 463 15 the the DT cord-346964-9afuen7k 463 16 enterocytes enterocyte NNS cord-346964-9afuen7k 463 17 , , , cord-346964-9afuen7k 463 18 and and CC cord-346964-9afuen7k 463 19 villous villous NNP cord-346964-9afuen7k 463 20 atrophy atrophy NN cord-346964-9afuen7k 463 21 that that WDT cord-346964-9afuen7k 463 22 are be VBP cord-346964-9afuen7k 463 23 reminiscent reminiscent JJ cord-346964-9afuen7k 463 24 of of IN cord-346964-9afuen7k 463 25 GVHD GVHD NNP cord-346964-9afuen7k 463 26 . . . cord-346964-9afuen7k 464 1 HIV HIV NNP cord-346964-9afuen7k 464 2 - - HYPH cord-346964-9afuen7k 464 3 associated associate VBN cord-346964-9afuen7k 464 4 pathology pathology NN cord-346964-9afuen7k 464 5 of of IN cord-346964-9afuen7k 464 6 the the DT cord-346964-9afuen7k 464 7 small small JJ cord-346964-9afuen7k 464 8 intestinal intestinal JJ cord-346964-9afuen7k 464 9 mucosa mucosa NN cord-346964-9afuen7k 464 10 is be VBZ cord-346964-9afuen7k 464 11 summarized summarize VBN cord-346964-9afuen7k 464 12 in in IN cord-346964-9afuen7k 464 13 Table Table NNP cord-346964-9afuen7k 464 14 9 9 CD cord-346964-9afuen7k 464 15 . . . cord-346964-9afuen7k 465 1 Table table NN cord-346964-9afuen7k 465 2 9 9 CD cord-346964-9afuen7k 465 3 Causes cause NNS cord-346964-9afuen7k 465 4 of of IN cord-346964-9afuen7k 465 5 HIV HIV NNP cord-346964-9afuen7k 465 6 - - HYPH cord-346964-9afuen7k 465 7 associated associate VBN cord-346964-9afuen7k 465 8 mucosal mucosal JJ cord-346964-9afuen7k 465 9 pathology pathology NN cord-346964-9afuen7k 465 10 _SP cord-346964-9afuen7k 465 11 Malabsorption malabsorption NN cord-346964-9afuen7k 465 12 work work NN cord-346964-9afuen7k 465 13 - - HYPH cord-346964-9afuen7k 465 14 up up NN cord-346964-9afuen7k 465 15 : : : cord-346964-9afuen7k 465 16 utility utility NN cord-346964-9afuen7k 465 17 of of IN cord-346964-9afuen7k 465 18 small small JJ cord-346964-9afuen7k 465 19 bowel bowel NN cord-346964-9afuen7k 465 20 biopsy biopsy NN cord-346964-9afuen7k 465 21 Pathophysiological Pathophysiological NNP cord-346964-9afuen7k 465 22 approach approach VBP cord-346964-9afuen7k 465 23 to to IN cord-346964-9afuen7k 465 24 chronic chronic JJ cord-346964-9afuen7k 465 25 diarrhoea diarrhoea NN cord-346964-9afuen7k 466 1 The the DT cord-346964-9afuen7k 466 2 nonneoplastic nonneoplastic JJ cord-346964-9afuen7k 466 3 small small JJ cord-346964-9afuen7k 466 4 intestine intestine NN cord-346964-9afuen7k 466 5 Diarrhoea Diarrhoea NNP cord-346964-9afuen7k 466 6 due due IN cord-346964-9afuen7k 466 7 to to IN cord-346964-9afuen7k 466 8 small small JJ cord-346964-9afuen7k 466 9 bowel bowel NN cord-346964-9afuen7k 466 10 diseases disease NNS cord-346964-9afuen7k 467 1 The the DT cord-346964-9afuen7k 467 2 pathology pathology NN cord-346964-9afuen7k 467 3 of of IN cord-346964-9afuen7k 467 4 malabsorption malabsorption NN cord-346964-9afuen7k 467 5 : : : cord-346964-9afuen7k 467 6 current current JJ cord-346964-9afuen7k 467 7 concepts concept NNS cord-346964-9afuen7k 468 1 An an DT cord-346964-9afuen7k 468 2 approach approach NN cord-346964-9afuen7k 468 3 to to IN cord-346964-9afuen7k 468 4 duodenal duodenal JJ cord-346964-9afuen7k 468 5 biopsies biopsy NNS cord-346964-9afuen7k 468 6 Small small JJ cord-346964-9afuen7k 468 7 bowel bowel NN cord-346964-9afuen7k 468 8 review review NN cord-346964-9afuen7k 468 9 : : : cord-346964-9afuen7k 468 10 disease disease NN cord-346964-9afuen7k 468 11 of of IN cord-346964-9afuen7k 468 12 the the DT cord-346964-9afuen7k 468 13 small small JJ cord-346964-9afuen7k 468 14 intestine intestine NN cord-346964-9afuen7k 468 15 Clinical clinical JJ cord-346964-9afuen7k 468 16 value value NN cord-346964-9afuen7k 468 17 of of IN cord-346964-9afuen7k 468 18 duodenal duodenal JJ cord-346964-9afuen7k 468 19 biopsies biopsy NNS cord-346964-9afuen7k 468 20 -beyond -beyond . cord-346964-9afuen7k 469 1 the the DT cord-346964-9afuen7k 469 2 diagnosis diagnosis NN cord-346964-9afuen7k 469 3 of of IN cord-346964-9afuen7k 469 4 coeliac coeliac JJ cord-346964-9afuen7k 469 5 disease disease NN cord-346964-9afuen7k 469 6 Gastric gastric JJ cord-346964-9afuen7k 469 7 and and CC cord-346964-9afuen7k 469 8 oesophageal oesophageal JJ cord-346964-9afuen7k 469 9 intraepithelial intraepithelial JJ cord-346964-9afuen7k 469 10 lymphocytes lymphocyte NNS cord-346964-9afuen7k 469 11 in in IN cord-346964-9afuen7k 469 12 paediatric paediatric JJ cord-346964-9afuen7k 469 13 coeliac coeliac JJ cord-346964-9afuen7k 469 14 disease disease NN cord-346964-9afuen7k 469 15 Intraepithelial Intraepithelial NNP cord-346964-9afuen7k 469 16 lymphocytes lymphocyte NNS cord-346964-9afuen7k 469 17 in in IN cord-346964-9afuen7k 469 18 the the DT cord-346964-9afuen7k 469 19 villous villous JJ cord-346964-9afuen7k 469 20 tip tip NN cord-346964-9afuen7k 469 21 : : : cord-346964-9afuen7k 469 22 do do VBP cord-346964-9afuen7k 469 23 they -PRON- PRP cord-346964-9afuen7k 469 24 indicate indicate VB cord-346964-9afuen7k 469 25 potential potential JJ cord-346964-9afuen7k 469 26 coeliac coeliac JJ cord-346964-9afuen7k 469 27 disease disease NN cord-346964-9afuen7k 469 28 ? ? . cord-346964-9afuen7k 470 1 Intraepithelial intraepithelial JJ cord-346964-9afuen7k 470 2 lymphocytosis lymphocytosis NN cord-346964-9afuen7k 470 3 in in IN cord-346964-9afuen7k 470 4 architecturally architecturally RB cord-346964-9afuen7k 470 5 preserved preserved JJ cord-346964-9afuen7k 470 6 proximal proximal JJ cord-346964-9afuen7k 470 7 small small JJ cord-346964-9afuen7k 470 8 intestinal intestinal JJ cord-346964-9afuen7k 470 9 mucosa mucosa JJ cord-346964-9afuen7k 470 10 Patchy patchy JJ cord-346964-9afuen7k 470 11 villous villous JJ cord-346964-9afuen7k 470 12 atrophy atrophy NN cord-346964-9afuen7k 470 13 of of IN cord-346964-9afuen7k 470 14 the the DT cord-346964-9afuen7k 470 15 duodenum duodenum NN cord-346964-9afuen7k 470 16 in in IN cord-346964-9afuen7k 470 17 childhood childhood NN cord-346964-9afuen7k 470 18 coeliac coeliac JJ cord-346964-9afuen7k 470 19 disease disease NN cord-346964-9afuen7k 470 20 Coeliac Coeliac NNP cord-346964-9afuen7k 470 21 disease disease NN cord-346964-9afuen7k 470 22 Refractory Refractory NNP cord-346964-9afuen7k 470 23 sprue sprue NN cord-346964-9afuen7k 470 24 syndrome syndrome NN cord-346964-9afuen7k 470 25 with with IN cord-346964-9afuen7k 470 26 clonal clonal JJ cord-346964-9afuen7k 470 27 intraepithelial intraepithelial JJ cord-346964-9afuen7k 470 28 lymphocytes lymphocyte NNS cord-346964-9afuen7k 470 29 evolving evolve VBG cord-346964-9afuen7k 470 30 into into IN cord-346964-9afuen7k 470 31 overt overt JJ cord-346964-9afuen7k 470 32 enteropathy enteropathy NN cord-346964-9afuen7k 470 33 - - HYPH cord-346964-9afuen7k 470 34 type type NN cord-346964-9afuen7k 470 35 intestinal intestinal JJ cord-346964-9afuen7k 470 36 T t NN cord-346964-9afuen7k 470 37 - - HYPH cord-346964-9afuen7k 470 38 cell cell NN cord-346964-9afuen7k 470 39 lymphoma lymphoma NN cord-346964-9afuen7k 470 40 Refractory refractory JJ cord-346964-9afuen7k 470 41 coeliac coeliac JJ cord-346964-9afuen7k 470 42 disease disease NN cord-346964-9afuen7k 470 43 Coeliac Coeliac NNP cord-346964-9afuen7k 470 44 disease disease NN cord-346964-9afuen7k 470 45 : : : cord-346964-9afuen7k 470 46 an an DT cord-346964-9afuen7k 470 47 update update NN cord-346964-9afuen7k 470 48 for for IN cord-346964-9afuen7k 470 49 pathologists pathologist NNS cord-346964-9afuen7k 470 50 Gluten gluten NN cord-346964-9afuen7k 470 51 - - HYPH cord-346964-9afuen7k 470 52 sensitive sensitive JJ cord-346964-9afuen7k 470 53 enteropathy enteropathy NNS cord-346964-9afuen7k 470 54 ( ( -LRB- cord-346964-9afuen7k 470 55 celiac celiac NNP cord-346964-9afuen7k 470 56 disease disease NN cord-346964-9afuen7k 470 57 ) ) -RRB- cord-346964-9afuen7k 470 58 : : : cord-346964-9afuen7k 470 59 controversies controversy NNS cord-346964-9afuen7k 470 60 in in IN cord-346964-9afuen7k 470 61 diagnosis diagnosis NN cord-346964-9afuen7k 470 62 and and CC cord-346964-9afuen7k 470 63 classification classification NN cord-346964-9afuen7k 470 64 Morphometric Morphometric NNP cord-346964-9afuen7k 470 65 analysis analysis NN cord-346964-9afuen7k 470 66 of of IN cord-346964-9afuen7k 470 67 intestinal intestinal JJ cord-346964-9afuen7k 470 68 mucosa mucosa NN cord-346964-9afuen7k 470 69 V. V. NNP cord-346964-9afuen7k 470 70 Quantitative quantitative JJ cord-346964-9afuen7k 470 71 histological histological JJ cord-346964-9afuen7k 470 72 and and CC cord-346964-9afuen7k 470 73 immunohistochemical immunohistochemical JJ cord-346964-9afuen7k 470 74 studies study NNS cord-346964-9afuen7k 470 75 of of IN cord-346964-9afuen7k 470 76 rectal rectal JJ cord-346964-9afuen7k 470 77 mucosae mucosae XX cord-346964-9afuen7k 470 78 in in IN cord-346964-9afuen7k 470 79 gluten gluten NN cord-346964-9afuen7k 470 80 sensitivity sensitivity NN cord-346964-9afuen7k 471 1 Morphologic morphologic JJ cord-346964-9afuen7k 471 2 features feature VBZ cord-346964-9afuen7k 471 3 suggestive suggestive JJ cord-346964-9afuen7k 471 4 of of IN cord-346964-9afuen7k 471 5 gluten gluten NN cord-346964-9afuen7k 471 6 sensitivity sensitivity NN cord-346964-9afuen7k 471 7 in in IN cord-346964-9afuen7k 471 8 architecturally architecturally RB cord-346964-9afuen7k 471 9 normal normal JJ cord-346964-9afuen7k 471 10 duodenal duodenal JJ cord-346964-9afuen7k 471 11 biopsy biopsy NN cord-346964-9afuen7k 471 12 specimens specimen NNS cord-346964-9afuen7k 471 13 Proximal Proximal NNP cord-346964-9afuen7k 471 14 small small JJ cord-346964-9afuen7k 471 15 bowel bowel NN cord-346964-9afuen7k 471 16 mucosal mucosal JJ cord-346964-9afuen7k 471 17 villous villous NNP cord-346964-9afuen7k 471 18 intraepithelial intraepithelial JJ cord-346964-9afuen7k 471 19 lymphocytes lymphocytes NNP cord-346964-9afuen7k 472 1 Prospective prospective JJ cord-346964-9afuen7k 472 2 study study NN cord-346964-9afuen7k 472 3 of of IN cord-346964-9afuen7k 472 4 the the DT cord-346964-9afuen7k 472 5 role role NN cord-346964-9afuen7k 472 6 of of IN cord-346964-9afuen7k 472 7 duodenal duodenal JJ cord-346964-9afuen7k 472 8 bulb bulb NN cord-346964-9afuen7k 472 9 biopsies biopsy NNS cord-346964-9afuen7k 472 10 in in IN cord-346964-9afuen7k 472 11 the the DT cord-346964-9afuen7k 472 12 diagnosis diagnosis NN cord-346964-9afuen7k 472 13 of of IN cord-346964-9afuen7k 472 14 celiac celiac JJ cord-346964-9afuen7k 472 15 disease disease NN cord-346964-9afuen7k 472 16 Gluten Gluten NNP cord-346964-9afuen7k 472 17 , , , cord-346964-9afuen7k 472 18 major major JJ cord-346964-9afuen7k 472 19 histocompatibility histocompatibility NN cord-346964-9afuen7k 472 20 complex complex NN cord-346964-9afuen7k 472 21 and and CC cord-346964-9afuen7k 472 22 the the DT cord-346964-9afuen7k 472 23 small small JJ cord-346964-9afuen7k 472 24 intestine intestine NN cord-346964-9afuen7k 472 25 : : : cord-346964-9afuen7k 472 26 a a DT cord-346964-9afuen7k 472 27 molecular molecular JJ cord-346964-9afuen7k 472 28 and and CC cord-346964-9afuen7k 472 29 immunobiologic immunobiologic JJ cord-346964-9afuen7k 472 30 approach approach NN cord-346964-9afuen7k 472 31 to to IN cord-346964-9afuen7k 472 32 the the DT cord-346964-9afuen7k 472 33 spectrum spectrum NN cord-346964-9afuen7k 472 34 of of IN cord-346964-9afuen7k 472 35 gluten gluten NN cord-346964-9afuen7k 472 36 sensitivity sensitivity NN cord-346964-9afuen7k 472 37 ( ( -LRB- cord-346964-9afuen7k 472 38 " " `` cord-346964-9afuen7k 472 39 coeliac coeliac JJ cord-346964-9afuen7k 472 40 sprue sprue NN cord-346964-9afuen7k 472 41 " " '' cord-346964-9afuen7k 472 42 ) ) -RRB- cord-346964-9afuen7k 472 43 Morphology morphology NN cord-346964-9afuen7k 472 44 of of IN cord-346964-9afuen7k 472 45 the the DT cord-346964-9afuen7k 472 46 mucosal mucosal JJ cord-346964-9afuen7k 472 47 lesion lesion NN cord-346964-9afuen7k 472 48 in in IN cord-346964-9afuen7k 472 49 gluten gluten NN cord-346964-9afuen7k 472 50 sensitivity sensitivity NN cord-346964-9afuen7k 472 51 Small small JJ cord-346964-9afuen7k 472 52 intestinal intestinal JJ cord-346964-9afuen7k 472 53 biopsies biopsy NNS cord-346964-9afuen7k 472 54 in in IN cord-346964-9afuen7k 472 55 celiac celiac JJ cord-346964-9afuen7k 472 56 disease disease NN cord-346964-9afuen7k 472 57 : : : cord-346964-9afuen7k 472 58 duodenal duodenal JJ cord-346964-9afuen7k 472 59 or or CC cord-346964-9afuen7k 472 60 jejunal jejunal JJ cord-346964-9afuen7k 472 61 ? ? . cord-346964-9afuen7k 473 1 Virchows Virchows NNP cord-346964-9afuen7k 473 2 Arch Arch NNP cord-346964-9afuen7k 473 3 Celiac Celiac NNP cord-346964-9afuen7k 473 4 disease disease NN cord-346964-9afuen7k 473 5 without without IN cord-346964-9afuen7k 473 6 villous villous NNP cord-346964-9afuen7k 473 7 atrophy atrophy NN cord-346964-9afuen7k 473 8 in in IN cord-346964-9afuen7k 473 9 children child NNS cord-346964-9afuen7k 474 1 : : : cord-346964-9afuen7k 474 2 a a DT cord-346964-9afuen7k 474 3 prospective prospective JJ cord-346964-9afuen7k 474 4 study study NN cord-346964-9afuen7k 475 1 The the DT cord-346964-9afuen7k 475 2 histopathology histopathology NN cord-346964-9afuen7k 475 3 of of IN cord-346964-9afuen7k 475 4 coeliac coeliac JJ cord-346964-9afuen7k 475 5 disease disease NN cord-346964-9afuen7k 475 6 : : : cord-346964-9afuen7k 475 7 time time NN cord-346964-9afuen7k 475 8 for for IN cord-346964-9afuen7k 475 9 a a DT cord-346964-9afuen7k 475 10 standardized standardized JJ cord-346964-9afuen7k 475 11 report report NN cord-346964-9afuen7k 475 12 scheme scheme NN cord-346964-9afuen7k 475 13 for for IN cord-346964-9afuen7k 475 14 pathologists pathologist NNS cord-346964-9afuen7k 475 15 How how WRB cord-346964-9afuen7k 475 16 many many JJ cord-346964-9afuen7k 475 17 duodenal duodenal JJ cord-346964-9afuen7k 475 18 biopsy biopsy NN cord-346964-9afuen7k 475 19 specimens specimen NNS cord-346964-9afuen7k 475 20 are be VBP cord-346964-9afuen7k 475 21 required require VBN cord-346964-9afuen7k 475 22 to to TO cord-346964-9afuen7k 475 23 make make VB cord-346964-9afuen7k 475 24 a a DT cord-346964-9afuen7k 475 25 diagnosis diagnosis NN cord-346964-9afuen7k 475 26 of of IN cord-346964-9afuen7k 475 27 celiac celiac JJ cord-346964-9afuen7k 475 28 disease disease NN cord-346964-9afuen7k 475 29 ? ? . cord-346964-9afuen7k 476 1 Variability variability NN cord-346964-9afuen7k 476 2 of of IN cord-346964-9afuen7k 476 3 histologic histologic JJ cord-346964-9afuen7k 476 4 lesions lesion NNS cord-346964-9afuen7k 476 5 in in IN cord-346964-9afuen7k 476 6 relation relation NN cord-346964-9afuen7k 476 7 to to IN cord-346964-9afuen7k 476 8 biopsy biopsy NN cord-346964-9afuen7k 476 9 site site NN cord-346964-9afuen7k 476 10 in in IN cord-346964-9afuen7k 476 11 gluten gluten NN cord-346964-9afuen7k 476 12 sensitive sensitive JJ cord-346964-9afuen7k 476 13 enteropathy enteropathy NNS cord-346964-9afuen7k 476 14 Immunoglobulin Immunoglobulin NNP cord-346964-9afuen7k 476 15 A a DT cord-346964-9afuen7k 476 16 autoantibodies autoantibody NNS cord-346964-9afuen7k 476 17 against against IN cord-346964-9afuen7k 476 18 transglutaminase transglutaminase NN cord-346964-9afuen7k 476 19 2 2 CD cord-346964-9afuen7k 476 20 in in IN cord-346964-9afuen7k 476 21 the the DT cord-346964-9afuen7k 476 22 small small JJ cord-346964-9afuen7k 476 23 intestinal intestinal JJ cord-346964-9afuen7k 476 24 mucosa mucosa NN cord-346964-9afuen7k 476 25 predict predict VBP cord-346964-9afuen7k 476 26 forthcoming forthcoming JJ cord-346964-9afuen7k 476 27 coeliac coeliac JJ cord-346964-9afuen7k 476 28 disease disease NN cord-346964-9afuen7k 476 29 Collagenous Collagenous NNP cord-346964-9afuen7k 476 30 spruean spruean JJ cord-346964-9afuen7k 476 31 unrecognized unrecognized JJ cord-346964-9afuen7k 476 32 type type NN cord-346964-9afuen7k 476 33 of of IN cord-346964-9afuen7k 476 34 malabsorption malabsorption NN cord-346964-9afuen7k 477 1 The the DT cord-346964-9afuen7k 477 2 role role NN cord-346964-9afuen7k 477 3 of of IN cord-346964-9afuen7k 477 4 esophagogastroduodenoscopy esophagogastroduodenoscopy NNP cord-346964-9afuen7k 477 5 in in IN cord-346964-9afuen7k 477 6 the the DT cord-346964-9afuen7k 477 7 initial initial JJ cord-346964-9afuen7k 477 8 evaluation evaluation NN cord-346964-9afuen7k 477 9 of of IN cord-346964-9afuen7k 477 10 childhood childhood NN cord-346964-9afuen7k 477 11 inflammatory inflammatory JJ cord-346964-9afuen7k 477 12 bowel bowel NN cord-346964-9afuen7k 477 13 disease disease NN cord-346964-9afuen7k 478 1 The the DT cord-346964-9afuen7k 478 2 face face NN cord-346964-9afuen7k 478 3 of of IN cord-346964-9afuen7k 478 4 tropical tropical JJ cord-346964-9afuen7k 478 5 sprue sprue NN cord-346964-9afuen7k 478 6 in in IN cord-346964-9afuen7k 478 7 2010 2010 CD cord-346964-9afuen7k 479 1 The the DT cord-346964-9afuen7k 479 2 significance significance NN cord-346964-9afuen7k 479 3 of of IN cord-346964-9afuen7k 479 4 duodenal duodenal JJ cord-346964-9afuen7k 479 5 mucosal mucosal JJ cord-346964-9afuen7k 479 6 atrophy atrophy NN cord-346964-9afuen7k 479 7 in in IN cord-346964-9afuen7k 479 8 patients patient NNS cord-346964-9afuen7k 479 9 with with IN cord-346964-9afuen7k 479 10 common common JJ cord-346964-9afuen7k 479 11 variable variable JJ cord-346964-9afuen7k 479 12 immunodeficiency immunodeficiency NN cord-346964-9afuen7k 479 13 : : : cord-346964-9afuen7k 479 14 a a DT cord-346964-9afuen7k 479 15 clinical clinical JJ cord-346964-9afuen7k 479 16 and and CC cord-346964-9afuen7k 479 17 histopathologic histopathologic JJ cord-346964-9afuen7k 479 18 study study NN cord-346964-9afuen7k 479 19 Diagnosis Diagnosis NNP cord-346964-9afuen7k 479 20 and and CC cord-346964-9afuen7k 479 21 management management NN cord-346964-9afuen7k 479 22 of of IN cord-346964-9afuen7k 479 23 small small JJ cord-346964-9afuen7k 479 24 intestinal intestinal JJ cord-346964-9afuen7k 479 25 bacterial bacterial JJ cord-346964-9afuen7k 479 26 overgrowth overgrowth NN cord-346964-9afuen7k 479 27 Amyloidosis Amyloidosis NNP cord-346964-9afuen7k 479 28 of of IN cord-346964-9afuen7k 479 29 the the DT cord-346964-9afuen7k 479 30 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 479 31 tract tract NN cord-346964-9afuen7k 479 32 : : : cord-346964-9afuen7k 479 33 a a DT cord-346964-9afuen7k 479 34 13-year 13-year JJ cord-346964-9afuen7k 479 35 , , , cord-346964-9afuen7k 479 36 single single JJ cord-346964-9afuen7k 479 37 - - HYPH cord-346964-9afuen7k 479 38 center center NN cord-346964-9afuen7k 479 39 , , , cord-346964-9afuen7k 479 40 referral referral JJ cord-346964-9afuen7k 479 41 experience experience NN cord-346964-9afuen7k 479 42 Autoimmune Autoimmune NNP cord-346964-9afuen7k 479 43 enteropathy enteropathy NNP cord-346964-9afuen7k 479 44 : : : cord-346964-9afuen7k 479 45 a a DT cord-346964-9afuen7k 479 46 review review NN cord-346964-9afuen7k 479 47 and and CC cord-346964-9afuen7k 479 48 update update NN cord-346964-9afuen7k 479 49 of of IN cord-346964-9afuen7k 479 50 clinical clinical JJ cord-346964-9afuen7k 479 51 management management NN cord-346964-9afuen7k 479 52 Post post NN cord-346964-9afuen7k 479 53 - - JJ cord-346964-9afuen7k 479 54 infectious infectious JJ cord-346964-9afuen7k 479 55 irritable irritable JJ cord-346964-9afuen7k 479 56 bowel bowel NN cord-346964-9afuen7k 479 57 syndrome syndrome NN cord-346964-9afuen7k 479 58 : : : cord-346964-9afuen7k 479 59 the the DT cord-346964-9afuen7k 479 60 past past NN cord-346964-9afuen7k 479 61 , , , cord-346964-9afuen7k 479 62 the the DT cord-346964-9afuen7k 479 63 present present NN cord-346964-9afuen7k 479 64 and and CC cord-346964-9afuen7k 479 65 the the DT cord-346964-9afuen7k 479 66 future future JJ cord-346964-9afuen7k 479 67 Diagnosis diagnosis NN cord-346964-9afuen7k 479 68 of of IN cord-346964-9afuen7k 479 69 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 479 70 graft graft NN cord-346964-9afuen7k 479 71 - - HYPH cord-346964-9afuen7k 479 72 versus versus IN cord-346964-9afuen7k 479 73 - - HYPH cord-346964-9afuen7k 479 74 host host NN cord-346964-9afuen7k 479 75 disease disease NN cord-346964-9afuen7k 479 76 Update update VBP cord-346964-9afuen7k 479 77 in in IN cord-346964-9afuen7k 479 78 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 479 79 allergic allergic JJ cord-346964-9afuen7k 479 80 diseases disease NNS cord-346964-9afuen7k 479 81 Loss Loss NNP cord-346964-9afuen7k 479 82 of of IN cord-346964-9afuen7k 479 83 both both DT cord-346964-9afuen7k 479 84 phospholipid phospholipid NN cord-346964-9afuen7k 479 85 and and CC cord-346964-9afuen7k 479 86 triglyceride triglyceride NN cord-346964-9afuen7k 479 87 transfer transfer NN cord-346964-9afuen7k 479 88 activities activity NNS cord-346964-9afuen7k 479 89 of of IN cord-346964-9afuen7k 479 90 microsomal microsomal NNP cord-346964-9afuen7k 479 91 triglyceride triglyceride NN cord-346964-9afuen7k 479 92 transfer transfer NN cord-346964-9afuen7k 479 93 protein protein NN cord-346964-9afuen7k 479 94 in in IN cord-346964-9afuen7k 479 95 abetalipoproteinemia abetalipoproteinemia NNP cord-346964-9afuen7k 479 96 Microvillous Microvillous NNP cord-346964-9afuen7k 479 97 inclusion inclusion NN cord-346964-9afuen7k 479 98 disease disease NN cord-346964-9afuen7k 479 99 - - : cord-346964-9afuen7k 479 100 an an DT cord-346964-9afuen7k 479 101 ultrastructural ultrastructural JJ cord-346964-9afuen7k 479 102 diagnosis diagnosis NN cord-346964-9afuen7k 479 103 : : : cord-346964-9afuen7k 479 104 with with IN cord-346964-9afuen7k 479 105 a a DT cord-346964-9afuen7k 479 106 review review NN cord-346964-9afuen7k 479 107 of of IN cord-346964-9afuen7k 479 108 the the DT cord-346964-9afuen7k 479 109 literature literature NN cord-346964-9afuen7k 479 110 Intractable intractable JJ cord-346964-9afuen7k 479 111 diarrhea diarrhea NN cord-346964-9afuen7k 479 112 with with IN cord-346964-9afuen7k 479 113 tufting tufte VBG cord-346964-9afuen7k 479 114 enteropathy enteropathy NNP cord-346964-9afuen7k 479 115 : : : cord-346964-9afuen7k 479 116 a a DT cord-346964-9afuen7k 479 117 favorable favorable JJ cord-346964-9afuen7k 479 118 outcome outcome NN cord-346964-9afuen7k 479 119 is be VBZ cord-346964-9afuen7k 479 120 possible possible JJ cord-346964-9afuen7k 479 121 Common common JJ cord-346964-9afuen7k 479 122 variable variable JJ cord-346964-9afuen7k 479 123 immune immune JJ cord-346964-9afuen7k 479 124 deficiency deficiency NN cord-346964-9afuen7k 479 125 in in IN cord-346964-9afuen7k 479 126 children child NNS cord-346964-9afuen7k 479 127 - - HYPH cord-346964-9afuen7k 479 128 clinical clinical JJ cord-346964-9afuen7k 479 129 characteristics characteristic NNS cord-346964-9afuen7k 479 130 varies vary VBZ cord-346964-9afuen7k 479 131 depending depend VBG cord-346964-9afuen7k 479 132 on on IN cord-346964-9afuen7k 479 133 defect defect NN cord-346964-9afuen7k 479 134 in in IN cord-346964-9afuen7k 479 135 peripheral peripheral JJ cord-346964-9afuen7k 479 136 B B NNP cord-346964-9afuen7k 479 137 cell cell NN cord-346964-9afuen7k 479 138 maturation maturation NN cord-346964-9afuen7k 479 139 Endoscopic endoscopic JJ cord-346964-9afuen7k 479 140 and and CC cord-346964-9afuen7k 479 141 histologic histologic JJ cord-346964-9afuen7k 479 142 diagnosis diagnosis NN cord-346964-9afuen7k 479 143 of of IN cord-346964-9afuen7k 479 144 intestinal intestinal JJ cord-346964-9afuen7k 479 145 graft graft NN cord-346964-9afuen7k 479 146 - - HYPH cord-346964-9afuen7k 479 147 versus versus IN cord-346964-9afuen7k 479 148 - - HYPH cord-346964-9afuen7k 479 149 host host NN cord-346964-9afuen7k 479 150 disease disease NN cord-346964-9afuen7k 479 151 after after IN cord-346964-9afuen7k 479 152 marrow marrow NN cord-346964-9afuen7k 479 153 transplantation transplantation NN cord-346964-9afuen7k 479 154 Tufting Tufting NNP cord-346964-9afuen7k 479 155 enteropathy enteropathy NNP cord-346964-9afuen7k 479 156 : : : cord-346964-9afuen7k 479 157 a a DT cord-346964-9afuen7k 479 158 newly newly RB cord-346964-9afuen7k 479 159 recognized recognize VBN cord-346964-9afuen7k 479 160 clinicopathological clinicopathological JJ cord-346964-9afuen7k 479 161 entity entity NN cord-346964-9afuen7k 479 162 associated associate VBN cord-346964-9afuen7k 479 163 with with IN cord-346964-9afuen7k 479 164 refractory refractory JJ cord-346964-9afuen7k 479 165 diarrhea diarrhea NN cord-346964-9afuen7k 479 166 in in IN cord-346964-9afuen7k 479 167 infants infant NNS cord-346964-9afuen7k 479 168 Eosinophilic eosinophilic JJ cord-346964-9afuen7k 479 169 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 479 170 disorders disorder NNS cord-346964-9afuen7k 479 171 ( ( -LRB- cord-346964-9afuen7k 479 172 EGID EGID NNP cord-346964-9afuen7k 479 173 ) ) -RRB- cord-346964-9afuen7k 480 1 Small small JJ cord-346964-9afuen7k 480 2 intestinal intestinal JJ cord-346964-9afuen7k 480 3 bacterial bacterial JJ cord-346964-9afuen7k 480 4 overgrowth overgrowth NN cord-346964-9afuen7k 480 5 ( ( -LRB- cord-346964-9afuen7k 480 6 SIBO SIBO NNP cord-346964-9afuen7k 480 7 ) ) -RRB- cord-346964-9afuen7k 480 8 in in IN cord-346964-9afuen7k 480 9 irritable irritable JJ cord-346964-9afuen7k 480 10 bowel bowel NN cord-346964-9afuen7k 480 11 syndrome syndrome NN cord-346964-9afuen7k 480 12 : : : cord-346964-9afuen7k 480 13 frequency frequency NN cord-346964-9afuen7k 480 14 and and CC cord-346964-9afuen7k 480 15 predictors predictor NNS cord-346964-9afuen7k 480 16 Absence absence NN cord-346964-9afuen7k 480 17 of of IN cord-346964-9afuen7k 480 18 cell cell NN cord-346964-9afuen7k 480 19 - - HYPH cord-346964-9afuen7k 480 20 surface surface NN cord-346964-9afuen7k 480 21 EpCAM EpCAM NNP cord-346964-9afuen7k 480 22 in in IN cord-346964-9afuen7k 480 23 congenital congenital JJ cord-346964-9afuen7k 480 24 tufting tufting NN cord-346964-9afuen7k 480 25 enteropathy enteropathy NNP cord-346964-9afuen7k 481 1 Microvillous microvillous JJ cord-346964-9afuen7k 481 2 inclusion inclusion NN cord-346964-9afuen7k 481 3 diseasean diseasean NNP cord-346964-9afuen7k 482 1 ultrastructural ultrastructural JJ cord-346964-9afuen7k 482 2 diagnosis diagnosis NN cord-346964-9afuen7k 482 3 : : : cord-346964-9afuen7k 482 4 with with IN cord-346964-9afuen7k 482 5 a a DT cord-346964-9afuen7k 482 6 review review NN cord-346964-9afuen7k 482 7 of of IN cord-346964-9afuen7k 482 8 the the DT cord-346964-9afuen7k 482 9 literature literature NN cord-346964-9afuen7k 482 10 Graft graft NN cord-346964-9afuen7k 482 11 - - HYPH cord-346964-9afuen7k 482 12 versus versus IN cord-346964-9afuen7k 482 13 - - HYPH cord-346964-9afuen7k 482 14 host host NN cord-346964-9afuen7k 482 15 disease disease NN cord-346964-9afuen7k 482 16 of of IN cord-346964-9afuen7k 482 17 the the DT cord-346964-9afuen7k 482 18 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 482 19 tract tract NN cord-346964-9afuen7k 482 20 Functional functional JJ cord-346964-9afuen7k 482 21 characterization characterization NN cord-346964-9afuen7k 482 22 of of IN cord-346964-9afuen7k 482 23 mutations mutation NNS cord-346964-9afuen7k 482 24 in in IN cord-346964-9afuen7k 482 25 the the DT cord-346964-9afuen7k 482 26 myosin myosin NN cord-346964-9afuen7k 482 27 Vb Vb NNP cord-346964-9afuen7k 482 28 gene gene NN cord-346964-9afuen7k 482 29 associated associate VBN cord-346964-9afuen7k 482 30 with with IN cord-346964-9afuen7k 482 31 microvillus microvillus NNP cord-346964-9afuen7k 482 32 inclusion inclusion NN cord-346964-9afuen7k 482 33 disease disease NN cord-346964-9afuen7k 482 34 Upper upper JJ cord-346964-9afuen7k 482 35 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 482 36 mucosal mucosal JJ cord-346964-9afuen7k 482 37 disease disease NN cord-346964-9afuen7k 482 38 in in IN cord-346964-9afuen7k 482 39 pediatric pediatric JJ cord-346964-9afuen7k 482 40 Crohn Crohn NNP cord-346964-9afuen7k 482 41 's 's POS cord-346964-9afuen7k 482 42 disease disease NN cord-346964-9afuen7k 482 43 and and CC cord-346964-9afuen7k 482 44 ulcerative ulcerative JJ cord-346964-9afuen7k 482 45 colitis colitis NN cord-346964-9afuen7k 482 46 : : : cord-346964-9afuen7k 482 47 a a DT cord-346964-9afuen7k 482 48 blinded blind VBN cord-346964-9afuen7k 482 49 , , , cord-346964-9afuen7k 482 50 controlled control VBN cord-346964-9afuen7k 482 51 study study NN cord-346964-9afuen7k 482 52 Diffuse Diffuse NNP cord-346964-9afuen7k 482 53 duodenitis duodenitis NN cord-346964-9afuen7k 482 54 associated associate VBN cord-346964-9afuen7k 482 55 with with IN cord-346964-9afuen7k 482 56 ulcerative ulcerative JJ cord-346964-9afuen7k 482 57 colitis colitis NN cord-346964-9afuen7k 482 58 Primary primary JJ cord-346964-9afuen7k 482 59 intestinal intestinal JJ cord-346964-9afuen7k 482 60 lymphangiectasia lymphangiectasia NNS cord-346964-9afuen7k 482 61 ( ( -LRB- cord-346964-9afuen7k 482 62 Waldmann Waldmann NNP cord-346964-9afuen7k 482 63 's 's POS cord-346964-9afuen7k 482 64 disease disease NN cord-346964-9afuen7k 482 65 ) ) -RRB- cord-346964-9afuen7k 483 1 Gastric gastric JJ cord-346964-9afuen7k 483 2 metaplasia metaplasia NN cord-346964-9afuen7k 483 3 and and CC cord-346964-9afuen7k 483 4 chronic chronic JJ cord-346964-9afuen7k 483 5 inflammation inflammation NN cord-346964-9afuen7k 483 6 at at IN cord-346964-9afuen7k 483 7 the the DT cord-346964-9afuen7k 483 8 duodenal duodenal JJ cord-346964-9afuen7k 483 9 bulb bulb NN cord-346964-9afuen7k 483 10 mucosa mucosa JJ cord-346964-9afuen7k 483 11 Gastric gastric JJ cord-346964-9afuen7k 483 12 metaplasia metaplasia NN cord-346964-9afuen7k 483 13 : : : cord-346964-9afuen7k 483 14 its -PRON- PRP$ cord-346964-9afuen7k 483 15 role role NN cord-346964-9afuen7k 483 16 in in IN cord-346964-9afuen7k 483 17 duodenal duodenal JJ cord-346964-9afuen7k 483 18 ulceration ulceration NN cord-346964-9afuen7k 483 19 Chronic Chronic NNP cord-346964-9afuen7k 483 20 diarrhea diarrhea NN cord-346964-9afuen7k 483 21 as as IN cord-346964-9afuen7k 483 22 the the DT cord-346964-9afuen7k 483 23 presenting present VBG cord-346964-9afuen7k 483 24 feature feature NN cord-346964-9afuen7k 483 25 of of IN cord-346964-9afuen7k 483 26 primary primary JJ cord-346964-9afuen7k 483 27 systemic systemic JJ cord-346964-9afuen7k 483 28 AL AL NNP cord-346964-9afuen7k 483 29 amyloidosis amyloidosis NN cord-346964-9afuen7k 483 30 : : : cord-346964-9afuen7k 483 31 serendipity serendipity NN cord-346964-9afuen7k 483 32 or or CC cord-346964-9afuen7k 483 33 delayed delay VBN cord-346964-9afuen7k 483 34 diagnosis diagnosis NN cord-346964-9afuen7k 483 35 ? ? . cord-346964-9afuen7k 484 1 Histology histology NN cord-346964-9afuen7k 484 2 of of IN cord-346964-9afuen7k 484 3 stomach stomach NN cord-346964-9afuen7k 484 4 and and CC cord-346964-9afuen7k 484 5 duodenum duodenum NN cord-346964-9afuen7k 484 6 in in IN cord-346964-9afuen7k 484 7 Crohn Crohn NNP cord-346964-9afuen7k 484 8 's 's POS cord-346964-9afuen7k 484 9 disease disease NN cord-346964-9afuen7k 484 10 Gastric gastric JJ cord-346964-9afuen7k 484 11 epithelium epithelium NN cord-346964-9afuen7k 484 12 in in IN cord-346964-9afuen7k 484 13 the the DT cord-346964-9afuen7k 484 14 duodenum duodenum NN cord-346964-9afuen7k 484 15 : : : cord-346964-9afuen7k 484 16 its -PRON- PRP$ cord-346964-9afuen7k 484 17 association association NN cord-346964-9afuen7k 484 18 with with IN cord-346964-9afuen7k 484 19 H. H. NNP cord-346964-9afuen7k 484 20 pylori pylori NN cord-346964-9afuen7k 484 21 and and CC cord-346964-9afuen7k 484 22 inflammation inflammation NN cord-346964-9afuen7k 485 1 Primary primary JJ cord-346964-9afuen7k 485 2 intestinal intestinal JJ cord-346964-9afuen7k 485 3 lymphangiectasia lymphangiectasia NNS cord-346964-9afuen7k 486 1 : : : cord-346964-9afuen7k 486 2 is be VBZ cord-346964-9afuen7k 486 3 it -PRON- PRP cord-346964-9afuen7k 486 4 always always RB cord-346964-9afuen7k 486 5 bad bad JJ cord-346964-9afuen7k 486 6 ? ? . cord-346964-9afuen7k 487 1 Two two CD cord-346964-9afuen7k 487 2 cases case NNS cord-346964-9afuen7k 487 3 with with IN cord-346964-9afuen7k 487 4 different different JJ cord-346964-9afuen7k 487 5 outcome outcome NN cord-346964-9afuen7k 487 6 Human human JJ cord-346964-9afuen7k 487 7 immunodeficiency immunodeficiency NN cord-346964-9afuen7k 487 8 virus virus NN cord-346964-9afuen7k 487 9 - - HYPH cord-346964-9afuen7k 487 10 associated associate VBN cord-346964-9afuen7k 487 11 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 487 12 disease disease NN cord-346964-9afuen7k 487 13 : : : cord-346964-9afuen7k 487 14 common common JJ cord-346964-9afuen7k 487 15 endoscopic endoscopic JJ cord-346964-9afuen7k 487 16 biopsy biopsy NN cord-346964-9afuen7k 487 17 diagnoses diagnose VBZ cord-346964-9afuen7k 487 18 Whipple Whipple NNP cord-346964-9afuen7k 487 19 disease disease NN cord-346964-9afuen7k 487 20 . . . cord-346964-9afuen7k 488 1 Clinical clinical JJ cord-346964-9afuen7k 488 2 review review NN cord-346964-9afuen7k 488 3 of of IN cord-346964-9afuen7k 488 4 52 52 CD cord-346964-9afuen7k 488 5 cases case NNS cord-346964-9afuen7k 488 6 Gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 488 7 infections infection NNS cord-346964-9afuen7k 488 8 in in IN cord-346964-9afuen7k 488 9 the the DT cord-346964-9afuen7k 488 10 immunocompromised immunocompromised JJ cord-346964-9afuen7k 488 11 host host NN cord-346964-9afuen7k 488 12 Neurologic neurologic JJ cord-346964-9afuen7k 488 13 presentation presentation NN cord-346964-9afuen7k 488 14 of of IN cord-346964-9afuen7k 488 15 Whipple Whipple NNP cord-346964-9afuen7k 488 16 disease disease NN cord-346964-9afuen7k 488 17 : : : cord-346964-9afuen7k 488 18 report report NN cord-346964-9afuen7k 488 19 of of IN cord-346964-9afuen7k 488 20 12 12 CD cord-346964-9afuen7k 488 21 cases case NNS cord-346964-9afuen7k 488 22 and and CC cord-346964-9afuen7k 488 23 review review NN cord-346964-9afuen7k 488 24 of of IN cord-346964-9afuen7k 488 25 the the DT cord-346964-9afuen7k 488 26 literature literature NN cord-346964-9afuen7k 488 27 Cytomegalovirus Cytomegalovirus NNP cord-346964-9afuen7k 488 28 infection infection NN cord-346964-9afuen7k 488 29 in in IN cord-346964-9afuen7k 488 30 steroid steroid JJ cord-346964-9afuen7k 488 31 - - HYPH cord-346964-9afuen7k 488 32 refractory refractory JJ cord-346964-9afuen7k 488 33 ulcerative ulcerative JJ cord-346964-9afuen7k 488 34 colitis colitis NN cord-346964-9afuen7k 488 35 : : : cord-346964-9afuen7k 488 36 a a DT cord-346964-9afuen7k 488 37 case case NN cord-346964-9afuen7k 488 38 - - HYPH cord-346964-9afuen7k 488 39 control control NN cord-346964-9afuen7k 488 40 study study NN cord-346964-9afuen7k 488 41 Pathology pathology NN cord-346964-9afuen7k 488 42 of of IN cord-346964-9afuen7k 488 43 food food NN cord-346964-9afuen7k 488 44 - - HYPH cord-346964-9afuen7k 488 45 borne bear VBN cord-346964-9afuen7k 488 46 infectious infectious JJ cord-346964-9afuen7k 488 47 diseases disease NNS cord-346964-9afuen7k 488 48 of of IN cord-346964-9afuen7k 488 49 the the DT cord-346964-9afuen7k 488 50 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 488 51 tract tract NN cord-346964-9afuen7k 488 52 : : : cord-346964-9afuen7k 488 53 an an DT cord-346964-9afuen7k 488 54 update update NN cord-346964-9afuen7k 488 55 Infective Infective NNP cord-346964-9afuen7k 488 56 disorders disorder NNS cord-346964-9afuen7k 488 57 of of IN cord-346964-9afuen7k 488 58 the the DT cord-346964-9afuen7k 488 59 gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 488 60 tract tract NN cord-346964-9afuen7k 488 61 Giardiasis giardiasis NN cord-346964-9afuen7k 488 62 : : : cord-346964-9afuen7k 488 63 a a DT cord-346964-9afuen7k 488 64 histologic histologic JJ cord-346964-9afuen7k 488 65 analysis analysis NN cord-346964-9afuen7k 488 66 of of IN cord-346964-9afuen7k 488 67 567 567 CD cord-346964-9afuen7k 488 68 cases case NNS cord-346964-9afuen7k 488 69 Giardia Giardia NNP cord-346964-9afuen7k 488 70 : : : cord-346964-9afuen7k 488 71 overview overview NN cord-346964-9afuen7k 488 72 and and CC cord-346964-9afuen7k 488 73 update update VB cord-346964-9afuen7k 488 74 Chorioretinitis Chorioretinitis NNP cord-346964-9afuen7k 488 75 and and CC cord-346964-9afuen7k 488 76 vitreitis vitreitis NN cord-346964-9afuen7k 488 77 due due IN cord-346964-9afuen7k 488 78 to to IN cord-346964-9afuen7k 488 79 Tropheryma Tropheryma NNP cord-346964-9afuen7k 488 80 whipplei whipplei NNP cord-346964-9afuen7k 488 81 after after IN cord-346964-9afuen7k 488 82 transplantation transplantation NN cord-346964-9afuen7k 488 83 : : : cord-346964-9afuen7k 488 84 case case NN cord-346964-9afuen7k 488 85 report report NN cord-346964-9afuen7k 488 86 and and CC cord-346964-9afuen7k 488 87 review review NN cord-346964-9afuen7k 488 88 Role role NN cord-346964-9afuen7k 488 89 of of IN cord-346964-9afuen7k 488 90 upper upper JJ cord-346964-9afuen7k 488 91 endoscopy endoscopy NN cord-346964-9afuen7k 488 92 in in IN cord-346964-9afuen7k 488 93 diagnosing diagnose VBG cord-346964-9afuen7k 488 94 opportunistic opportunistic JJ cord-346964-9afuen7k 488 95 infections infection NNS cord-346964-9afuen7k 488 96 in in IN cord-346964-9afuen7k 488 97 human human JJ cord-346964-9afuen7k 488 98 immunodeficiency immunodeficiency NN cord-346964-9afuen7k 488 99 virus virus NN cord-346964-9afuen7k 488 100 - - HYPH cord-346964-9afuen7k 488 101 infected infect VBN cord-346964-9afuen7k 488 102 patients patient NNS cord-346964-9afuen7k 488 103 A a DT cord-346964-9afuen7k 488 104 rare rare JJ cord-346964-9afuen7k 488 105 cause cause NN cord-346964-9afuen7k 488 106 of of IN cord-346964-9afuen7k 488 107 an an DT cord-346964-9afuen7k 488 108 ileocecal ileocecal JJ cord-346964-9afuen7k 488 109 fistula fistula NN cord-346964-9afuen7k 488 110 in in IN cord-346964-9afuen7k 488 111 an an DT cord-346964-9afuen7k 488 112 AIDS AIDS NNP cord-346964-9afuen7k 488 113 patient patient NN cord-346964-9afuen7k 488 114 . . . cord-346964-9afuen7k 489 1 Gastrointestinal gastrointestinal JJ cord-346964-9afuen7k 489 2 infection infection NN cord-346964-9afuen7k 489 3 by by IN cord-346964-9afuen7k 489 4 Histoplasma Histoplasma NNP cord-346964-9afuen7k 489 5 capsulatum capsulatum NN cord-346964-9afuen7k 489 6 infection infection NN cord-346964-9afuen7k 489 7 identified identify VBN cord-346964-9afuen7k 489 8 with with IN cord-346964-9afuen7k 489 9 internal internal JJ cord-346964-9afuen7k 489 10 transcribed transcribe VBN cord-346964-9afuen7k 489 11 spacer spacer NN cord-346964-9afuen7k 489 12 primer primer NN cord-346964-9afuen7k 489 13 sets set NNS