id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000104-3b8b8p61	McWhirter, Sarah M.	A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP	2009-08-31		.txt	text/plain	8572	499	56	The potency of cytosolic signaling induced by c-di-GMP is comparable to that induced by cytosolic delivery of DNA, and both nucleic acids induce a similar transcriptional profile, including triggering of type I interferons and coregulated genes via induction of TBK1, IRF3, nuclear factor κB, and MAP kinases. Cell type-specific responses to cytosolic DNA and c-di-GMP Collectively, these results suggest that there are strong similarities in the signaling pathways triggered by the cytosolic presence of c-di-GMP and other nucleic acids, such as DNA and RNA. These results suggest that at least one component of the host signaling pathway responding to c-di-GMP is distinct from that used for responses to cytosolic RNA or DNA, and is differentially expressed in different cell types.	./cache/cord-000104-3b8b8p61.txt	./txt/cord-000104-3b8b8p61.txt