id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003764-141u6ax7	Shrestha, Ashish C.	Cytolytic Perforin as an Adjuvant to Enhance the Immunogenicity of DNA Vaccines	2019-04-30		.txt	text/plain	6292	309	42	The ability of a DNA vaccine to elicit T cell immunity is thus dependent on activating APCs to present antigen: MHC complexes to T cells [31] and adjuvants can serve as an important costimulatory factor to enhance this process. The use of fusogenic membrane glycoprotein (FMG) gene from VSV vaccine encoding the H7 protein of human papillomavirus type 16 was shown to enhance ell responses and effectively control growth of tumors [87] . The use of fusogenic membrane glycoprotein (FMG) gene from VSV in a DNA vaccine encoding the H7 protein of human papillomavirus type 16 was shown to enhance CD8 + T cell responses and effectively control growth of tumors [87] . This cytolytic DNA vaccine is unique as it is based on a bicistronic plasmid with the ability to coexpress antigen and PRF in a balanced mechanism causing necrosis of vaccine-transduced cells, followed by increased activation of immune cells and cross presentation of vaccine immunogen.	./cache/cord-003764-141u6ax7.txt	./txt/cord-003764-141u6ax7.txt