id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258623-9evwcs32	Roembke, Benjamin T.	Nucleic acid detection using G-quadruplex amplification methodologies	2013-12-15		.txt	text/plain	4218	235	58	Willner and co-workers also reported nucleic acid detection using a symmetric split G-quadruplex probe but instead of DAB, the Willner group used luminol as a reductant for a luminescent readout (Fig. 3 ) [22] . Wang and co-workers have described an interesting ''split'' molecular beacon G-quadruplex probe that can be used to detect DNA or thrombin (a dual probe, Fig. 12 ) [31] . When there is no target DNA, and both molecular beacons are intact, the probe can form a complete G-quadruplex, resulting in an active DNAzyme peroxidase. To create a turn on probe the authors used the blocker DNA in a twostep amplification process, in which the blocker DNA would lose affinity for the MB and bind the DNA analyte of interest resulting in the molecular beacon refolding and forming an active G-quadruplex peroxidase. Willner and co-workers showed that upon binding of a target to a MB G-quadruplex probe that was attached to a gold electrode, a G-quadruplex forms.	./cache/cord-258623-9evwcs32.txt	./txt/cord-258623-9evwcs32.txt