id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272357-fxe49zen	Campolongo, Michael J.	DNA nanomedicine: Engineering DNA as a polymer for therapeutic and diagnostic applications()	2010-04-30		.txt	text/plain	7365	419	43	Nanomedicine, the application of nanotechnology to medicine, encompasses a broad spectrum of fields including molecular detection, diagnostics, drug delivery, gene regulation and protein production. There are a variety of systems that take advantage of the hybridisation of linear DNA for nanomedicine applications, including oligonucleotide sensing, multiplexed pathogen detection, aptameric drug delivery and diagnostics, as well as stimuli-responsive hydrogels. Notably, a nanoparticle-based biobarcode assay was developed for the ultrasensitive detection of biomolecules, such as proteins [44] [45] [46] [47] [48] , messenger RNA (mRNA) [49] and the human immunodeficiency virus (HIV)-1 antigen [50] , as well as for the multiplexed detection with high selectivity but without the need for enzymatic target amplification and labelling [28, 47] (Fig. 2B) . Over the past 17 years, aptamers have been generated against a wide array of molecular targets, including many known proteins, carbohydrates, lipids, nucleotides and other small molecules, as well as highly complex structures such as viruses [64] [65] [66] .	./cache/cord-272357-fxe49zen.txt	./txt/cord-272357-fxe49zen.txt