id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274644-gr1eaj6k	Chen, Zhao-Chi	Thermally stable and uniform DNA amplification with picosecond laser ablated graphene rapid thermal cycling device	2019-12-15		.txt	text/plain	5152	265	59	This study reports a straightforward fabrication technique for patterning an on-chip graphene-based device with hole arrays, in which the mechanism of surface structures can achieve stable and uniform thermal control for the amplification of DNA fragments. Our results demonstrated that the proposed integration of a graphene-based device and a laser-pulse ablation process to form a thin-film PCR device has cost benefits in a small-volume reagent and holds great promise for practical medical use of DNA amplification. DNA amplification is performed using thermal cycling, with a high degree of control of stable and uniform temperature distribution being attributed to array structures (Bigham et al., 2017; Seo et al., 2018) , microchannel heat exchangers (Riera et al., 2013) , membrane-based microfluidics (Chen and Shen, 2017) , and doped hybrid materials (Seo et al., 2016) .	./cache/cord-274644-gr1eaj6k.txt	./txt/cord-274644-gr1eaj6k.txt