id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326228-9x1233q6	Holley, Caroline L	The rOX‐stars of inflammation: links between the inflammasome and mitochondrial meltdown	2020-02-10		.txt	text/plain	6351	434	32	Nod-like receptor protein 3 (NLRP3) is a cytosolic PRR activated by a wide range of PAMPs (bacterial toxins, fungal and viral components) and DAMPs (e.g. extracellular ATP, lysosomal-disrupting crystals), including those of mitochondrial origin. The mechanisms by which mitochondria influence PRR activity and drive inflammatory responses are important research foci for understanding protective innate immune functions during host defence against infection, as well as innate immune pathology in disease. 55 It is possible that LLO-driven MAM disruption and mitochondrial fission removes a key site of inflammasome assembly to dampen K + effluxdependent NLRP3 signalling and thereby allows the bacterium to partially evade immune recognition. NLRP3 activation in mouse macrophages can be associated with loss of mitochondrial membrane potential or defective mitophagy, leading to mitoROS production and mtDNA release from mitochondria to the cytosol. cGAS/STING signalling may also be a downstream consequence of NLRP3 activation; for example, IL-1R signalling in the human THP-1 myeloid cell line drives loss of mitochondrial membrane potential and recognition of mtDNA by cGAS.	./cache/cord-326228-9x1233q6.txt	./txt/cord-326228-9x1233q6.txt