id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317787-6hz8dxsi	Jaffey, Jared A.	Presumptive Development of Fibrotic Lung Disease From Bordetella bronchiseptica and Post-infectious Bronchiolitis Obliterans in a Dog	2019-10-10		.txt	text/plain	4442	246	37	Keywords: pulmonary fibrosis, canine infectious respiratory disease complex (CIRDC), pulmonary hypertension, pneumonia, interstitial lung disease, PIBO BACKGROUND Post-infectious bronchiolitis obliterans (PIBO), a syndrome in children most commonly caused by Mycoplasma pneumonia (1, 2) and adenovirus (1) and occasionally Bordetella pertussis (3, 4) is associated with chronic inflammatory and fibrotic lesions of small airways leading to chronic airflow obstruction (5) . Importantly, severe damage to the lung can lead to end-stage and untreatable fibrosis, with most cases in dogs not having a recognizable trigger and thus being termed "idiopathic pulmonary fibrosis." This report describes a puppy developing PIBO after Bordetella bronchiseptica pneumonia with histologic evidence of small airway changes strongly supporting development of pulmonary fibrosis. Post-infectious bronchiolitis obliterans, a syndrome in children that can be caused by adenovirus, Mycoplasma pneumonia, and less commonly Bordetella pertussis, is treated after resolution of infection with supportive therapies and corticosteroids to target inflammation (1-3).	./cache/cord-317787-6hz8dxsi.txt	./txt/cord-317787-6hz8dxsi.txt