id sid tid token lemma pos cord-255011-7oqfod62 1 1 key key JJ cord-255011-7oqfod62 1 2 : : : cord-255011-7oqfod62 1 3 cord-255011 cord-255011 NNP cord-255011-7oqfod62 1 4 - - HYPH cord-255011-7oqfod62 1 5 7oqfod62 7oqfod62 CD cord-255011-7oqfod62 1 6 authors author NNS cord-255011-7oqfod62 1 7 : : : cord-255011-7oqfod62 1 8 Erles Erles NNP cord-255011-7oqfod62 1 9 , , , cord-255011-7oqfod62 1 10 Kerstin Kerstin NNP cord-255011-7oqfod62 1 11 ; ; : cord-255011-7oqfod62 1 12 Brownlie Brownlie NNP cord-255011-7oqfod62 1 13 , , , cord-255011-7oqfod62 1 14 Joe Joe NNP cord-255011-7oqfod62 1 15 title title NN cord-255011-7oqfod62 1 16 : : : cord-255011-7oqfod62 1 17 Canine Canine NNP cord-255011-7oqfod62 1 18 Respiratory respiratory JJ cord-255011-7oqfod62 1 19 Coronavirus Coronavirus NNP cord-255011-7oqfod62 1 20 : : : cord-255011-7oqfod62 2 1 An an DT cord-255011-7oqfod62 2 2 Emerging emerge VBG cord-255011-7oqfod62 2 3 Pathogen Pathogen NNP cord-255011-7oqfod62 2 4 in in IN cord-255011-7oqfod62 2 5 the the DT cord-255011-7oqfod62 2 6 Canine Canine NNP cord-255011-7oqfod62 2 7 Infectious Infectious NNP cord-255011-7oqfod62 2 8 Respiratory Respiratory NNP cord-255011-7oqfod62 2 9 Disease Disease NNP cord-255011-7oqfod62 2 10 Complex Complex NNP cord-255011-7oqfod62 2 11 date date NN cord-255011-7oqfod62 2 12 : : : cord-255011-7oqfod62 2 13 2008 2008 CD cord-255011-7oqfod62 2 14 - - SYM cord-255011-7oqfod62 2 15 05 05 CD cord-255011-7oqfod62 2 16 - - HYPH cord-255011-7oqfod62 2 17 22 22 CD cord-255011-7oqfod62 2 18 journal journal NN cord-255011-7oqfod62 2 19 : : : cord-255011-7oqfod62 2 20 Vet Vet NNP cord-255011-7oqfod62 2 21 Clin Clin NNP cord-255011-7oqfod62 2 22 North North NNP cord-255011-7oqfod62 2 23 Am Am NNP cord-255011-7oqfod62 2 24 Small small JJ cord-255011-7oqfod62 2 25 Anim Anim NNP cord-255011-7oqfod62 2 26 Pract Pract NNP cord-255011-7oqfod62 3 1 DOI DOI NNP cord-255011-7oqfod62 3 2 : : : cord-255011-7oqfod62 3 3 10.1016 10.1016 CD cord-255011-7oqfod62 3 4 / / SYM cord-255011-7oqfod62 3 5 j.cvsm.2008.02.008 j.cvsm.2008.02.008 NNP cord-255011-7oqfod62 3 6 sha sha NN cord-255011-7oqfod62 3 7 : : : cord-255011-7oqfod62 3 8 ec45faad31211e333615d55e05e23e7a4861e8c7 ec45faad31211e333615d55e05e23e7a4861e8c7 NNP cord-255011-7oqfod62 3 9 doc_id doc_id CD cord-255011-7oqfod62 3 10 : : : cord-255011-7oqfod62 3 11 255011 255011 CD cord-255011-7oqfod62 3 12 cord_uid cord_uid NNS cord-255011-7oqfod62 3 13 : : : cord-255011-7oqfod62 4 1 7oqfod62 7oqfod62 CD cord-255011-7oqfod62 4 2 Infectious infectious JJ cord-255011-7oqfod62 4 3 respiratory respiratory JJ cord-255011-7oqfod62 4 4 disease disease NN cord-255011-7oqfod62 4 5 in in IN cord-255011-7oqfod62 4 6 dogs dog NNS cord-255011-7oqfod62 4 7 is be VBZ cord-255011-7oqfod62 4 8 a a DT cord-255011-7oqfod62 4 9 constant constant JJ cord-255011-7oqfod62 4 10 challenge challenge NN cord-255011-7oqfod62 4 11 because because IN cord-255011-7oqfod62 4 12 of of IN cord-255011-7oqfod62 4 13 the the DT cord-255011-7oqfod62 4 14 involvement involvement NN cord-255011-7oqfod62 4 15 of of IN cord-255011-7oqfod62 4 16 several several JJ cord-255011-7oqfod62 4 17 pathogens pathogen NNS cord-255011-7oqfod62 4 18 and and CC cord-255011-7oqfod62 4 19 environmental environmental JJ cord-255011-7oqfod62 4 20 factors factor NNS cord-255011-7oqfod62 4 21 . . . cord-255011-7oqfod62 5 1 Canine canine JJ cord-255011-7oqfod62 5 2 respiratory respiratory JJ cord-255011-7oqfod62 5 3 coronavirus coronavirus NN cord-255011-7oqfod62 5 4 ( ( -LRB- cord-255011-7oqfod62 5 5 CRCoV crcov NN cord-255011-7oqfod62 5 6 ) ) -RRB- cord-255011-7oqfod62 5 7 is be VBZ cord-255011-7oqfod62 5 8 a a DT cord-255011-7oqfod62 5 9 new new JJ cord-255011-7oqfod62 5 10 coronavirus coronavirus NN cord-255011-7oqfod62 5 11 of of IN cord-255011-7oqfod62 5 12 dogs dog NNS cord-255011-7oqfod62 5 13 , , , cord-255011-7oqfod62 5 14 which which WDT cord-255011-7oqfod62 5 15 is be VBZ cord-255011-7oqfod62 5 16 widespread widespread JJ cord-255011-7oqfod62 5 17 in in IN cord-255011-7oqfod62 5 18 North North NNP cord-255011-7oqfod62 5 19 America America NNP cord-255011-7oqfod62 5 20 , , , cord-255011-7oqfod62 5 21 Japan Japan NNP cord-255011-7oqfod62 5 22 , , , cord-255011-7oqfod62 5 23 and and CC cord-255011-7oqfod62 5 24 several several JJ cord-255011-7oqfod62 5 25 European european JJ cord-255011-7oqfod62 5 26 countries country NNS cord-255011-7oqfod62 5 27 . . . cord-255011-7oqfod62 6 1 CRCoV CRCoV NNP cord-255011-7oqfod62 6 2 has have VBZ cord-255011-7oqfod62 6 3 been be VBN cord-255011-7oqfod62 6 4 associated associate VBN cord-255011-7oqfod62 6 5 with with IN cord-255011-7oqfod62 6 6 respiratory respiratory JJ cord-255011-7oqfod62 6 7 disease disease NN cord-255011-7oqfod62 6 8 , , , cord-255011-7oqfod62 6 9 particularly particularly RB cord-255011-7oqfod62 6 10 in in IN cord-255011-7oqfod62 6 11 kenneled kennel VBN cord-255011-7oqfod62 6 12 dog dog NN cord-255011-7oqfod62 6 13 populations population NNS cord-255011-7oqfod62 6 14 . . . cord-255011-7oqfod62 7 1 The the DT cord-255011-7oqfod62 7 2 virus virus NN cord-255011-7oqfod62 7 3 is be VBZ cord-255011-7oqfod62 7 4 genetically genetically RB cord-255011-7oqfod62 7 5 and and CC cord-255011-7oqfod62 7 6 antigenically antigenically RB cord-255011-7oqfod62 7 7 distinct distinct JJ cord-255011-7oqfod62 7 8 from from IN cord-255011-7oqfod62 7 9 enteric enteric JJ cord-255011-7oqfod62 7 10 canine canine JJ cord-255011-7oqfod62 7 11 coronavirus coronavirus NN cord-255011-7oqfod62 7 12 ; ; : cord-255011-7oqfod62 7 13 therefore therefore RB cord-255011-7oqfod62 7 14 , , , cord-255011-7oqfod62 7 15 specific specific JJ cord-255011-7oqfod62 7 16 tests test NNS cord-255011-7oqfod62 7 17 are be VBP cord-255011-7oqfod62 7 18 required require VBN cord-255011-7oqfod62 7 19 for for IN cord-255011-7oqfod62 7 20 diagnosis diagnosis NN cord-255011-7oqfod62 7 21 . . . cord-255011-7oqfod62 8 1 R r NN cord-255011-7oqfod62 8 2 espiratory espiratory JJ cord-255011-7oqfod62 8 3 disease disease NN cord-255011-7oqfod62 8 4 in in IN cord-255011-7oqfod62 8 5 dogs dog NNS cord-255011-7oqfod62 8 6 is be VBZ cord-255011-7oqfod62 8 7 generally generally RB cord-255011-7oqfod62 8 8 of of IN cord-255011-7oqfod62 8 9 greatest great JJS cord-255011-7oqfod62 8 10 importance importance NN cord-255011-7oqfod62 8 11 in in IN cord-255011-7oqfod62 8 12 establishments establishment NNS cord-255011-7oqfod62 8 13 in in IN cord-255011-7oqfod62 8 14 which which WDT cord-255011-7oqfod62 8 15 dogs dog NNS cord-255011-7oqfod62 8 16 are be VBP cord-255011-7oqfod62 8 17 housed house VBN cord-255011-7oqfod62 8 18 in in IN cord-255011-7oqfod62 8 19 groups group NNS cord-255011-7oqfod62 8 20 , , , cord-255011-7oqfod62 8 21 such such JJ cord-255011-7oqfod62 8 22 as as IN cord-255011-7oqfod62 8 23 shelters shelter NNS cord-255011-7oqfod62 8 24 , , , cord-255011-7oqfod62 8 25 boarding board VBG cord-255011-7oqfod62 8 26 kennels kennel NNS cord-255011-7oqfod62 8 27 , , , cord-255011-7oqfod62 8 28 and and CC cord-255011-7oqfod62 8 29 veterinary veterinary JJ cord-255011-7oqfod62 8 30 hospitals hospital NNS cord-255011-7oqfod62 8 31 . . . cord-255011-7oqfod62 9 1 Disease disease NN cord-255011-7oqfod62 9 2 outbreaks outbreak NNS cord-255011-7oqfod62 9 3 involving involve VBG cord-255011-7oqfod62 9 4 only only RB cord-255011-7oqfod62 9 5 one one CD cord-255011-7oqfod62 9 6 species species NN cord-255011-7oqfod62 9 7 of of IN cord-255011-7oqfod62 9 8 infectious infectious JJ cord-255011-7oqfod62 9 9 agent agent NN cord-255011-7oqfod62 9 10 are be VBP cord-255011-7oqfod62 9 11 possible possible JJ cord-255011-7oqfod62 9 12 , , , cord-255011-7oqfod62 9 13 as as IN cord-255011-7oqfod62 9 14 seen see VBN cord-255011-7oqfod62 9 15 in in IN cord-255011-7oqfod62 9 16 distemper distemper NN cord-255011-7oqfod62 9 17 outbreaks outbreak NNS cord-255011-7oqfod62 9 18 in in IN cord-255011-7oqfod62 9 19 susceptible susceptible JJ cord-255011-7oqfod62 9 20 populations population NNS cord-255011-7oqfod62 9 21 [ [ -LRB- cord-255011-7oqfod62 9 22 1 1 CD cord-255011-7oqfod62 9 23 ] ] -RRB- cord-255011-7oqfod62 9 24 . . . cord-255011-7oqfod62 10 1 Most most RBS cord-255011-7oqfod62 10 2 commonly commonly RB cord-255011-7oqfod62 10 3 , , , cord-255011-7oqfod62 10 4 however however RB cord-255011-7oqfod62 10 5 , , , cord-255011-7oqfod62 10 6 infectious infectious JJ cord-255011-7oqfod62 10 7 respiratory respiratory JJ cord-255011-7oqfod62 10 8 disease disease NN cord-255011-7oqfod62 10 9 in in IN cord-255011-7oqfod62 10 10 dogs dog NNS cord-255011-7oqfod62 10 11 has have VBZ cord-255011-7oqfod62 10 12 a a DT cord-255011-7oqfod62 10 13 multifactorial multifactorial JJ cord-255011-7oqfod62 10 14 etiology etiology NN cord-255011-7oqfod62 10 15 and and CC cord-255011-7oqfod62 10 16 is be VBZ cord-255011-7oqfod62 10 17 best well RBS cord-255011-7oqfod62 10 18 described describe VBN cord-255011-7oqfod62 10 19 as as IN cord-255011-7oqfod62 10 20 canine canine JJ cord-255011-7oqfod62 10 21 infectious infectious JJ cord-255011-7oqfod62 10 22 respiratory respiratory JJ cord-255011-7oqfod62 10 23 disease disease NN cord-255011-7oqfod62 10 24 ( ( -LRB- cord-255011-7oqfod62 10 25 CIRD CIRD NNP cord-255011-7oqfod62 10 26 ) ) -RRB- cord-255011-7oqfod62 10 27 complex complex JJ cord-255011-7oqfod62 10 28 ( ( -LRB- cord-255011-7oqfod62 10 29 also also RB cord-255011-7oqfod62 10 30 known know VBN cord-255011-7oqfod62 10 31 as as IN cord-255011-7oqfod62 10 32 ' ' '' cord-255011-7oqfod62 10 33 ' ' '' cord-255011-7oqfod62 10 34 kennel kennel NN cord-255011-7oqfod62 10 35 cough cough NN cord-255011-7oqfod62 10 36 ' ' '' cord-255011-7oqfod62 10 37 ' ' '' cord-255011-7oqfod62 10 38 ) ) -RRB- cord-255011-7oqfod62 10 39 . . . cord-255011-7oqfod62 11 1 Viruses virus NNS cord-255011-7oqfod62 11 2 detected detect VBN cord-255011-7oqfod62 11 3 in in IN cord-255011-7oqfod62 11 4 dogs dog NNS cord-255011-7oqfod62 11 5 with with IN cord-255011-7oqfod62 11 6 CIRD CIRD NNP cord-255011-7oqfod62 11 7 include include VBP cord-255011-7oqfod62 11 8 canine canine JJ cord-255011-7oqfod62 11 9 parainfluenza parainfluenza NN cord-255011-7oqfod62 11 10 virus virus NN cord-255011-7oqfod62 11 11 ( ( -LRB- cord-255011-7oqfod62 11 12 CPIV CPIV NNP cord-255011-7oqfod62 11 13 ) ) -RRB- cord-255011-7oqfod62 11 14 [ [ -LRB- cord-255011-7oqfod62 11 15 2 2 CD cord-255011-7oqfod62 11 16 ] ] -RRB- cord-255011-7oqfod62 11 17 , , , cord-255011-7oqfod62 11 18 canine canine JJ cord-255011-7oqfod62 11 19 adenovirus adenovirus NN cord-255011-7oqfod62 11 20 ( ( -LRB- cord-255011-7oqfod62 11 21 CAV CAV NNP cord-255011-7oqfod62 11 22 ) ) -RRB- cord-255011-7oqfod62 11 23 type type NN cord-255011-7oqfod62 11 24 2 2 CD cord-255011-7oqfod62 11 25 [ [ -LRB- cord-255011-7oqfod62 11 26 3 3 CD cord-255011-7oqfod62 11 27 ] ] -RRB- cord-255011-7oqfod62 11 28 and and CC cord-255011-7oqfod62 11 29 canine canine JJ cord-255011-7oqfod62 11 30 herpesvirus herpesvirus NN cord-255011-7oqfod62 11 31 [ [ -LRB- cord-255011-7oqfod62 11 32 4 4 CD cord-255011-7oqfod62 11 33 ] ] -RRB- cord-255011-7oqfod62 11 34 . . . cord-255011-7oqfod62 12 1 Canine canine JJ cord-255011-7oqfod62 12 2 influenza influenza NN cord-255011-7oqfod62 12 3 virus virus NN cord-255011-7oqfod62 12 4 , , , cord-255011-7oqfod62 12 5 which which WDT cord-255011-7oqfod62 12 6 recently recently RB cord-255011-7oqfod62 12 7 has have VBZ cord-255011-7oqfod62 12 8 been be VBN cord-255011-7oqfod62 12 9 detected detect VBN cord-255011-7oqfod62 12 10 in in IN cord-255011-7oqfod62 12 11 some some DT cord-255011-7oqfod62 12 12 parts part NNS cord-255011-7oqfod62 12 13 of of IN cord-255011-7oqfod62 12 14 the the DT cord-255011-7oqfod62 12 15 United United NNP cord-255011-7oqfod62 12 16 States States NNP cord-255011-7oqfod62 12 17 , , , cord-255011-7oqfod62 12 18 is be VBZ cord-255011-7oqfod62 12 19 likely likely JJ cord-255011-7oqfod62 12 20 to to TO cord-255011-7oqfod62 12 21 become become VB cord-255011-7oqfod62 12 22 part part NN cord-255011-7oqfod62 12 23 of of IN cord-255011-7oqfod62 12 24 the the DT cord-255011-7oqfod62 12 25 disease disease NN cord-255011-7oqfod62 12 26 complex complex NN cord-255011-7oqfod62 12 27 because because IN cord-255011-7oqfod62 12 28 it -PRON- PRP cord-255011-7oqfod62 12 29 often often RB cord-255011-7oqfod62 12 30 causes cause VBZ cord-255011-7oqfod62 12 31 mild mild JJ cord-255011-7oqfod62 12 32 respiratory respiratory JJ cord-255011-7oqfod62 12 33 disease disease NN cord-255011-7oqfod62 12 34 characterized characterize VBN cord-255011-7oqfod62 12 35 by by IN cord-255011-7oqfod62 12 36 nasal nasal JJ cord-255011-7oqfod62 12 37 discharge discharge NN cord-255011-7oqfod62 12 38 and and CC cord-255011-7oqfod62 12 39 persistent persistent JJ cord-255011-7oqfod62 12 40 cough cough NN cord-255011-7oqfod62 12 41 [ [ -LRB- cord-255011-7oqfod62 12 42 5 5 CD cord-255011-7oqfod62 12 43 ] ] -RRB- cord-255011-7oqfod62 12 44 . . . cord-255011-7oqfod62 13 1 Bacteria Bacteria NNS cord-255011-7oqfod62 13 2 are be VBP cord-255011-7oqfod62 13 3 important important JJ cord-255011-7oqfod62 13 4 in in IN cord-255011-7oqfod62 13 5 CIRD CIRD NNP cord-255011-7oqfod62 13 6 as as IN cord-255011-7oqfod62 13 7 primary primary JJ cord-255011-7oqfod62 13 8 pathogens pathogen NNS cord-255011-7oqfod62 13 9 and and CC cord-255011-7oqfod62 13 10 as as IN cord-255011-7oqfod62 13 11 a a DT cord-255011-7oqfod62 13 12 cause cause NN cord-255011-7oqfod62 13 13 of of IN cord-255011-7oqfod62 13 14 secondary secondary JJ cord-255011-7oqfod62 13 15 infections infection NNS cord-255011-7oqfod62 13 16 . . . cord-255011-7oqfod62 14 1 Bordetella Bordetella NNP cord-255011-7oqfod62 14 2 bronchiseptica bronchiseptica NNP cord-255011-7oqfod62 14 3 is be VBZ cord-255011-7oqfod62 14 4 the the DT cord-255011-7oqfod62 14 5 bacterium bacterium NN cord-255011-7oqfod62 14 6 most most RBS cord-255011-7oqfod62 14 7 frequently frequently RB cord-255011-7oqfod62 14 8 associated associate VBN cord-255011-7oqfod62 14 9 with with IN cord-255011-7oqfod62 14 10 CIRD CIRD NNP cord-255011-7oqfod62 14 11 [ [ -LRB- cord-255011-7oqfod62 14 12 6 6 CD cord-255011-7oqfod62 14 13 ] ] -RRB- cord-255011-7oqfod62 14 14 , , , cord-255011-7oqfod62 14 15 but but CC cord-255011-7oqfod62 14 16 mycoplasmas mycoplasmas NN cord-255011-7oqfod62 14 17 , , , cord-255011-7oqfod62 14 18 particularly particularly RB cord-255011-7oqfod62 14 19 Mycoplasma Mycoplasma NNP cord-255011-7oqfod62 14 20 cynos cynos NNP cord-255011-7oqfod62 14 21 , , , cord-255011-7oqfod62 14 22 have have VBP cord-255011-7oqfod62 14 23 also also RB cord-255011-7oqfod62 14 24 been be VBN cord-255011-7oqfod62 14 25 linked link VBN cord-255011-7oqfod62 14 26 to to IN cord-255011-7oqfod62 14 27 the the DT cord-255011-7oqfod62 14 28 disease disease NN cord-255011-7oqfod62 14 29 [ [ -LRB- cord-255011-7oqfod62 14 30 6 6 CD cord-255011-7oqfod62 14 31 , , , cord-255011-7oqfod62 14 32 7 7 CD cord-255011-7oqfod62 14 33 ] ] -RRB- cord-255011-7oqfod62 14 34 . . . cord-255011-7oqfod62 15 1 Streptococcus streptococcus NN cord-255011-7oqfod62 15 2 equi equi NN cord-255011-7oqfod62 15 3 subsp subsp NN cord-255011-7oqfod62 15 4 . . . cord-255011-7oqfod62 16 1 zooepidemicus zooepidemicus NNP cord-255011-7oqfod62 16 2 has have VBZ cord-255011-7oqfod62 16 3 been be VBN cord-255011-7oqfod62 16 4 isolated isolate VBN cord-255011-7oqfod62 16 5 from from IN cord-255011-7oqfod62 16 6 severe severe JJ cord-255011-7oqfod62 16 7 cases case NNS cord-255011-7oqfod62 16 8 of of IN cord-255011-7oqfod62 16 9 respiratory respiratory JJ cord-255011-7oqfod62 16 10 disease disease NN cord-255011-7oqfod62 16 11 that that WDT cord-255011-7oqfod62 16 12 were be VBD cord-255011-7oqfod62 16 13 frequently frequently RB cord-255011-7oqfod62 16 14 fatal fatal JJ cord-255011-7oqfod62 16 15 [ [ -LRB- cord-255011-7oqfod62 16 16 8 8 CD cord-255011-7oqfod62 16 17 ] ] -RRB- cord-255011-7oqfod62 16 18 . . . cord-255011-7oqfod62 17 1 Vaccines vaccine NNS cord-255011-7oqfod62 17 2 have have VBP cord-255011-7oqfod62 17 3 been be VBN cord-255011-7oqfod62 17 4 developed develop VBN cord-255011-7oqfod62 17 5 for for IN cord-255011-7oqfod62 17 6 protection protection NN cord-255011-7oqfod62 17 7 against against IN cord-255011-7oqfod62 17 8 several several JJ cord-255011-7oqfod62 17 9 canine canine JJ cord-255011-7oqfod62 17 10 respiratory respiratory JJ cord-255011-7oqfod62 17 11 pathogens pathogen NNS cord-255011-7oqfod62 17 12 . . . cord-255011-7oqfod62 18 1 Combination combination NN cord-255011-7oqfod62 18 2 vaccines vaccine NNS cord-255011-7oqfod62 18 3 routinely routinely RB cord-255011-7oqfod62 18 4 contain contain VBP cord-255011-7oqfod62 18 5 canine canine JJ cord-255011-7oqfod62 18 6 distemper distemper NN cord-255011-7oqfod62 18 7 virus virus NN cord-255011-7oqfod62 18 8 and and CC cord-255011-7oqfod62 18 9 CAV-1 CAV-1 NNP cord-255011-7oqfod62 18 10 or or CC cord-255011-7oqfod62 18 11 CAV-2 CAV-2 NNP cord-255011-7oqfod62 18 12 . . . cord-255011-7oqfod62 19 1 CAV CAV NNP cord-255011-7oqfod62 19 2 vaccines vaccine NNS cord-255011-7oqfod62 19 3 confer confer VBP cord-255011-7oqfod62 19 4 cross cross NN cord-255011-7oqfod62 19 5 - - NN cord-255011-7oqfod62 19 6 protection protection NN cord-255011-7oqfod62 19 7 against against IN cord-255011-7oqfod62 19 8 type type NN cord-255011-7oqfod62 19 9 1 1 CD cord-255011-7oqfod62 19 10 ( ( -LRB- cord-255011-7oqfod62 19 11 the the DT cord-255011-7oqfod62 19 12 cause cause NN cord-255011-7oqfod62 19 13 of of IN cord-255011-7oqfod62 19 14 canine canine JJ cord-255011-7oqfod62 19 15 infectious infectious JJ cord-255011-7oqfod62 19 16 hepatitis hepatitis NN cord-255011-7oqfod62 19 17 ) ) -RRB- cord-255011-7oqfod62 19 18 and and CC cord-255011-7oqfod62 19 19 type type NN cord-255011-7oqfod62 19 20 2 2 CD cord-255011-7oqfod62 19 21 ( ( -LRB- cord-255011-7oqfod62 19 22 associated associate VBN cord-255011-7oqfod62 19 23 with with IN cord-255011-7oqfod62 19 24 respiratory respiratory JJ cord-255011-7oqfod62 19 25 disease disease NN cord-255011-7oqfod62 19 26 ) ) -RRB- cord-255011-7oqfod62 19 27 . . . cord-255011-7oqfod62 20 1 CPIV CPIV NNP cord-255011-7oqfod62 20 2 is be VBZ cord-255011-7oqfod62 20 3 also also RB cord-255011-7oqfod62 20 4 included include VBN cord-255011-7oqfod62 20 5 in in IN cord-255011-7oqfod62 20 6 several several JJ cord-255011-7oqfod62 20 7 multivalent multivalent JJ cord-255011-7oqfod62 20 8 vaccines vaccine NNS cord-255011-7oqfod62 20 9 , , , cord-255011-7oqfod62 20 10 or or CC cord-255011-7oqfod62 20 11 it -PRON- PRP cord-255011-7oqfod62 20 12 is be VBZ cord-255011-7oqfod62 20 13 available available JJ cord-255011-7oqfod62 20 14 in in IN cord-255011-7oqfod62 20 15 combination combination NN cord-255011-7oqfod62 20 16 with with IN cord-255011-7oqfod62 20 17 B B NNP cord-255011-7oqfod62 20 18 bronchiseptica bronchiseptica NNP cord-255011-7oqfod62 20 19 as as IN cord-255011-7oqfod62 20 20 a a DT cord-255011-7oqfod62 20 21 ' ' `` cord-255011-7oqfod62 20 22 ' ' '' cord-255011-7oqfod62 20 23 kennel kennel NN cord-255011-7oqfod62 20 24 cough cough NN cord-255011-7oqfod62 20 25 vaccine vaccine NN cord-255011-7oqfod62 20 26 . . . cord-255011-7oqfod62 20 27 ' ' '' cord-255011-7oqfod62 20 28 ' ' '' cord-255011-7oqfod62 21 1 This this DT cord-255011-7oqfod62 21 2 work work NN cord-255011-7oqfod62 21 3 was be VBD cord-255011-7oqfod62 21 4 supported support VBN cord-255011-7oqfod62 21 5 by by IN cord-255011-7oqfod62 21 6 Battersea Battersea NNP cord-255011-7oqfod62 21 7 Dogs Dogs NNP cord-255011-7oqfod62 21 8 and and CC cord-255011-7oqfod62 21 9 Cats Cats NNPS cord-255011-7oqfod62 21 10 Home Home NNP cord-255011-7oqfod62 21 11 and and CC cord-255011-7oqfod62 21 12 The the DT cord-255011-7oqfod62 21 13 Guide Guide NNP cord-255011-7oqfod62 22 1 Dogs dog NNS cord-255011-7oqfod62 22 2 for for IN cord-255011-7oqfod62 22 3 the the DT cord-255011-7oqfod62 22 4 Blind Blind NNP cord-255011-7oqfod62 22 5 Association Association NNP cord-255011-7oqfod62 22 6 . . . cord-255011-7oqfod62 22 7 _SP cord-255011-7oqfod62 23 1 Canine canine JJ cord-255011-7oqfod62 23 2 respiratory respiratory JJ cord-255011-7oqfod62 23 3 coronavirus coronavirus NN cord-255011-7oqfod62 23 4 ( ( -LRB- cord-255011-7oqfod62 23 5 CRCoV crcov NN cord-255011-7oqfod62 23 6 ) ) -RRB- cord-255011-7oqfod62 23 7 was be VBD cord-255011-7oqfod62 23 8 first first RB cord-255011-7oqfod62 23 9 detected detect VBN cord-255011-7oqfod62 23 10 in in IN cord-255011-7oqfod62 23 11 2003 2003 CD cord-255011-7oqfod62 23 12 in in IN cord-255011-7oqfod62 23 13 dogs dog NNS cord-255011-7oqfod62 23 14 housed house VBN cord-255011-7oqfod62 23 15 at at IN cord-255011-7oqfod62 23 16 a a DT cord-255011-7oqfod62 23 17 UK UK NNP cord-255011-7oqfod62 23 18 rehoming rehome VBG cord-255011-7oqfod62 23 19 center center NN cord-255011-7oqfod62 23 20 [ [ -LRB- cord-255011-7oqfod62 23 21 9 9 CD cord-255011-7oqfod62 23 22 ] ] -RRB- cord-255011-7oqfod62 23 23 . . . cord-255011-7oqfod62 24 1 The the DT cord-255011-7oqfod62 24 2 center center NN cord-255011-7oqfod62 24 3 had have VBD cord-255011-7oqfod62 24 4 a a DT cord-255011-7oqfod62 24 5 high high JJ cord-255011-7oqfod62 24 6 turnover turnover NN cord-255011-7oqfod62 24 7 of of IN cord-255011-7oqfod62 24 8 dogs dog NNS cord-255011-7oqfod62 24 9 and and CC cord-255011-7oqfod62 24 10 was be VBD cord-255011-7oqfod62 24 11 reporting report VBG cord-255011-7oqfod62 24 12 problems problem NNS cord-255011-7oqfod62 24 13 with with IN cord-255011-7oqfod62 24 14 enzootic enzootic JJ cord-255011-7oqfod62 24 15 respiratory respiratory JJ cord-255011-7oqfod62 24 16 disease disease NN cord-255011-7oqfod62 24 17 despite despite IN cord-255011-7oqfod62 24 18 regular regular JJ cord-255011-7oqfod62 24 19 vaccination vaccination NN cord-255011-7oqfod62 24 20 . . . cord-255011-7oqfod62 25 1 An an DT cord-255011-7oqfod62 25 2 investigation investigation NN cord-255011-7oqfod62 25 3 into into IN cord-255011-7oqfod62 25 4 pathogens pathogen NNS cord-255011-7oqfod62 25 5 associated associate VBN cord-255011-7oqfod62 25 6 with with IN cord-255011-7oqfod62 25 7 CIRD CIRD NNP cord-255011-7oqfod62 25 8 in in IN cord-255011-7oqfod62 25 9 this this DT cord-255011-7oqfod62 25 10 population population NN cord-255011-7oqfod62 25 11 led lead VBD cord-255011-7oqfod62 25 12 to to IN cord-255011-7oqfod62 25 13 the the DT cord-255011-7oqfod62 25 14 detection detection NN cord-255011-7oqfod62 25 15 of of IN cord-255011-7oqfod62 25 16 a a DT cord-255011-7oqfod62 25 17 coronavirus coronavirus NN cord-255011-7oqfod62 25 18 in in IN cord-255011-7oqfod62 25 19 tracheal tracheal NN cord-255011-7oqfod62 25 20 and and CC cord-255011-7oqfod62 25 21 lung lung NN cord-255011-7oqfod62 25 22 samples sample NNS cord-255011-7oqfod62 25 23 by by IN cord-255011-7oqfod62 25 24 reverse reverse JJ cord-255011-7oqfod62 25 25 transcriptase transcriptase NN cord-255011-7oqfod62 25 26 polymerase polymerase NN cord-255011-7oqfod62 25 27 chain chain NN cord-255011-7oqfod62 25 28 reaction reaction NN cord-255011-7oqfod62 25 29 ( ( -LRB- cord-255011-7oqfod62 25 30 RT RT NNP cord-255011-7oqfod62 25 31 - - HYPH cord-255011-7oqfod62 25 32 PCR PCR NNP cord-255011-7oqfod62 25 33 ) ) -RRB- cord-255011-7oqfod62 25 34 . . . cord-255011-7oqfod62 26 1 Coronaviruses coronaviruse NNS cord-255011-7oqfod62 26 2 are be VBP cord-255011-7oqfod62 26 3 large large JJ cord-255011-7oqfod62 26 4 enveloped envelop VBN cord-255011-7oqfod62 26 5 viruses virus NNS cord-255011-7oqfod62 26 6 containing contain VBG cord-255011-7oqfod62 26 7 a a DT cord-255011-7oqfod62 26 8 positive positive JJ cord-255011-7oqfod62 26 9 - - HYPH cord-255011-7oqfod62 26 10 sense sense NN cord-255011-7oqfod62 26 11 singlestranded singlestranded NNP cord-255011-7oqfod62 26 12 RNA RNA NNP cord-255011-7oqfod62 26 13 genome genome NN cord-255011-7oqfod62 26 14 . . . cord-255011-7oqfod62 27 1 The the DT cord-255011-7oqfod62 27 2 structural structural JJ cord-255011-7oqfod62 27 3 proteins protein NNS cord-255011-7oqfod62 27 4 located locate VBN cord-255011-7oqfod62 27 5 in in IN cord-255011-7oqfod62 27 6 the the DT cord-255011-7oqfod62 27 7 viral viral JJ cord-255011-7oqfod62 27 8 envelope envelope NN cord-255011-7oqfod62 27 9 include include VBP cord-255011-7oqfod62 27 10 the the DT cord-255011-7oqfod62 27 11 spike spike NN cord-255011-7oqfod62 27 12 protein protein NN cord-255011-7oqfod62 27 13 ( ( -LRB- cord-255011-7oqfod62 27 14 S S NNP cord-255011-7oqfod62 27 15 ) ) -RRB- cord-255011-7oqfod62 27 16 , , , cord-255011-7oqfod62 27 17 the the DT cord-255011-7oqfod62 27 18 membrane membrane NN cord-255011-7oqfod62 27 19 protein protein NN cord-255011-7oqfod62 27 20 ( ( -LRB- cord-255011-7oqfod62 27 21 M M NNP cord-255011-7oqfod62 27 22 ) ) -RRB- cord-255011-7oqfod62 27 23 , , , cord-255011-7oqfod62 27 24 and and CC cord-255011-7oqfod62 27 25 the the DT cord-255011-7oqfod62 27 26 small small JJ cord-255011-7oqfod62 27 27 membrane membrane NN cord-255011-7oqfod62 27 28 protein protein NN cord-255011-7oqfod62 27 29 ( ( -LRB- cord-255011-7oqfod62 27 30 E E NNP cord-255011-7oqfod62 27 31 ) ) -RRB- cord-255011-7oqfod62 27 32 . . . cord-255011-7oqfod62 28 1 Initial initial JJ cord-255011-7oqfod62 28 2 sequence sequence NN cord-255011-7oqfod62 28 3 analysis analysis NN cord-255011-7oqfod62 28 4 of of IN cord-255011-7oqfod62 28 5 CRCoV CRCoV NNP cord-255011-7oqfod62 28 6 showed show VBD cord-255011-7oqfod62 28 7 a a DT cord-255011-7oqfod62 28 8 high high JJ cord-255011-7oqfod62 28 9 similarity similarity NN cord-255011-7oqfod62 28 10 to to IN cord-255011-7oqfod62 28 11 bovine bovine JJ cord-255011-7oqfod62 28 12 coronavirus coronavirus NN cord-255011-7oqfod62 28 13 ( ( -LRB- cord-255011-7oqfod62 28 14 BCoV BCoV NNP cord-255011-7oqfod62 28 15 ) ) -RRB- cord-255011-7oqfod62 28 16 and and CC cord-255011-7oqfod62 29 1 human human JJ cord-255011-7oqfod62 29 2 coronavirus coronavirus NN cord-255011-7oqfod62 29 3 OC43 OC43 NNP cord-255011-7oqfod62 29 4 ( ( -LRB- cord-255011-7oqfod62 29 5 96 96 CD cord-255011-7oqfod62 29 6 % % NN cord-255011-7oqfod62 29 7 amino amino NN cord-255011-7oqfod62 29 8 acid acid NN cord-255011-7oqfod62 29 9 identity identity NN cord-255011-7oqfod62 29 10 with with IN cord-255011-7oqfod62 29 11 BCoV BCoV NNP cord-255011-7oqfod62 29 12 in in IN cord-255011-7oqfod62 29 13 the the DT cord-255011-7oqfod62 29 14 variable variable JJ cord-255011-7oqfod62 29 15 spike spike NN cord-255011-7oqfod62 29 16 protein protein NN cord-255011-7oqfod62 29 17 ) ) -RRB- cord-255011-7oqfod62 29 18 . . . cord-255011-7oqfod62 30 1 Coronaviruses Coronaviruses NNP cord-255011-7oqfod62 30 2 had have VBD cord-255011-7oqfod62 30 3 been be VBN cord-255011-7oqfod62 30 4 described describe VBN cord-255011-7oqfod62 30 5 before before RB cord-255011-7oqfod62 30 6 in in IN cord-255011-7oqfod62 30 7 dogs dog NNS cord-255011-7oqfod62 30 8 with with IN cord-255011-7oqfod62 30 9 gastroenteritis gastroenteritis NN cord-255011-7oqfod62 30 10 [ [ -LRB- cord-255011-7oqfod62 30 11 10 10 CD cord-255011-7oqfod62 30 12 ] ] -RRB- cord-255011-7oqfod62 30 13 ; ; : cord-255011-7oqfod62 30 14 however however RB cord-255011-7oqfod62 30 15 , , , cord-255011-7oqfod62 30 16 it -PRON- PRP cord-255011-7oqfod62 30 17 was be VBD cord-255011-7oqfod62 30 18 shown show VBN cord-255011-7oqfod62 30 19 that that IN cord-255011-7oqfod62 30 20 CRCoV crcov NN cord-255011-7oqfod62 30 21 was be VBD cord-255011-7oqfod62 30 22 distinct distinct JJ cord-255011-7oqfod62 30 23 from from IN cord-255011-7oqfod62 30 24 the the DT cord-255011-7oqfod62 30 25 previously previously RB cord-255011-7oqfod62 30 26 known know VBN cord-255011-7oqfod62 30 27 canine canine JJ cord-255011-7oqfod62 30 28 coronavirus coronavirus NN cord-255011-7oqfod62 30 29 ( ( -LRB- cord-255011-7oqfod62 30 30 CCoV ccov ADD cord-255011-7oqfod62 30 31 ) ) -RRB- cord-255011-7oqfod62 30 32 . . . cord-255011-7oqfod62 31 1 The the DT cord-255011-7oqfod62 31 2 virus virus NN cord-255011-7oqfod62 31 3 showed show VBD cord-255011-7oqfod62 31 4 only only RB cord-255011-7oqfod62 31 5 69 69 CD cord-255011-7oqfod62 31 6 % % NN cord-255011-7oqfod62 31 7 nucleotide nucleotide JJ cord-255011-7oqfod62 31 8 identity identity NN cord-255011-7oqfod62 31 9 in in IN cord-255011-7oqfod62 31 10 the the DT cord-255011-7oqfod62 31 11 highly highly RB cord-255011-7oqfod62 31 12 conserved conserved JJ cord-255011-7oqfod62 31 13 polymerase polymerase NN cord-255011-7oqfod62 31 14 region region NN cord-255011-7oqfod62 31 15 and and CC cord-255011-7oqfod62 31 16 only only RB cord-255011-7oqfod62 31 17 21 21 CD cord-255011-7oqfod62 31 18 % % NN cord-255011-7oqfod62 31 19 amino amino NN cord-255011-7oqfod62 31 20 acid acid NN cord-255011-7oqfod62 31 21 sequence sequence NN cord-255011-7oqfod62 31 22 identity identity NN cord-255011-7oqfod62 31 23 in in IN cord-255011-7oqfod62 31 24 the the DT cord-255011-7oqfod62 31 25 spike spike NN cord-255011-7oqfod62 31 26 protein protein NN cord-255011-7oqfod62 31 27 , , , cord-255011-7oqfod62 31 28 indicating indicate VBG cord-255011-7oqfod62 31 29 that that IN cord-255011-7oqfod62 31 30 CRCoV crcov NN cord-255011-7oqfod62 31 31 was be VBD cord-255011-7oqfod62 31 32 a a DT cord-255011-7oqfod62 31 33 novel novel JJ cord-255011-7oqfod62 31 34 coronavirus coronavirus NN cord-255011-7oqfod62 31 35 of of IN cord-255011-7oqfod62 31 36 dogs dog NNS cord-255011-7oqfod62 31 37 . . . cord-255011-7oqfod62 32 1 Members member NNS cord-255011-7oqfod62 32 2 of of IN cord-255011-7oqfod62 32 3 the the DT cord-255011-7oqfod62 32 4 family family NN cord-255011-7oqfod62 32 5 Coronaviridae Coronaviridae NNP cord-255011-7oqfod62 32 6 are be VBP cord-255011-7oqfod62 32 7 separated separate VBN cord-255011-7oqfod62 32 8 into into IN cord-255011-7oqfod62 32 9 groups group NNS cord-255011-7oqfod62 32 10 according accord VBG cord-255011-7oqfod62 32 11 to to IN cord-255011-7oqfod62 32 12 their -PRON- PRP$ cord-255011-7oqfod62 32 13 genetic genetic JJ cord-255011-7oqfod62 32 14 similarities similarity NNS cord-255011-7oqfod62 32 15 [ [ -LRB- cord-255011-7oqfod62 32 16 11 11 CD cord-255011-7oqfod62 32 17 ] ] -RRB- cord-255011-7oqfod62 32 18 . . . cord-255011-7oqfod62 33 1 Most Most JJS cord-255011-7oqfod62 33 2 members member NNS cord-255011-7oqfod62 33 3 of of IN cord-255011-7oqfod62 33 4 group group NN cord-255011-7oqfod62 33 5 2 2 CD cord-255011-7oqfod62 33 6 of of IN cord-255011-7oqfod62 33 7 coronaviruses coronaviruse NNS cord-255011-7oqfod62 33 8 contain contain VBP cord-255011-7oqfod62 33 9 an an DT cord-255011-7oqfod62 33 10 additional additional JJ cord-255011-7oqfod62 33 11 gene gene NN cord-255011-7oqfod62 33 12 coding coding NN cord-255011-7oqfod62 33 13 for for IN cord-255011-7oqfod62 33 14 a a DT cord-255011-7oqfod62 33 15 surface surface NN cord-255011-7oqfod62 33 16 hemagglutinin hemagglutinin NN cord-255011-7oqfod62 33 17 - - HYPH cord-255011-7oqfod62 33 18 esterase esterase NN cord-255011-7oqfod62 33 19 protein protein NN cord-255011-7oqfod62 33 20 . . . cord-255011-7oqfod62 34 1 This this DT cord-255011-7oqfod62 34 2 gene gene NN cord-255011-7oqfod62 34 3 was be VBD cord-255011-7oqfod62 34 4 found find VBN cord-255011-7oqfod62 34 5 to to TO cord-255011-7oqfod62 34 6 be be VB cord-255011-7oqfod62 34 7 present present JJ cord-255011-7oqfod62 34 8 in in IN cord-255011-7oqfod62 34 9 CRCoV crcov NN cord-255011-7oqfod62 34 10 , , , cord-255011-7oqfod62 34 11 confirming confirm VBG cord-255011-7oqfod62 34 12 its -PRON- PRP$ cord-255011-7oqfod62 34 13 place place NN cord-255011-7oqfod62 34 14 in in IN cord-255011-7oqfod62 34 15 group group NN cord-255011-7oqfod62 34 16 2 2 CD cord-255011-7oqfod62 34 17 together together RB cord-255011-7oqfod62 34 18 with with IN cord-255011-7oqfod62 34 19 its -PRON- PRP$ cord-255011-7oqfod62 34 20 closest close JJS cord-255011-7oqfod62 34 21 relative relative NN cord-255011-7oqfod62 34 22 , , , cord-255011-7oqfod62 34 23 BCoV BCoV NNP cord-255011-7oqfod62 34 24 ( ( -LRB- cord-255011-7oqfod62 34 25 Fig Fig NNP cord-255011-7oqfod62 34 26 . . . cord-255011-7oqfod62 34 27 1 1 CD cord-255011-7oqfod62 34 28 ) ) -RRB- cord-255011-7oqfod62 34 29 . . . cord-255011-7oqfod62 35 1 CCoV CCoV NNP cord-255011-7oqfod62 35 2 , , , cord-255011-7oqfod62 35 3 in in IN cord-255011-7oqfod62 35 4 contrast contrast NN cord-255011-7oqfod62 35 5 is be VBZ cord-255011-7oqfod62 35 6 a a DT cord-255011-7oqfod62 35 7 member member NN cord-255011-7oqfod62 35 8 of of IN cord-255011-7oqfod62 35 9 group group NN cord-255011-7oqfod62 35 10 1 1 CD cord-255011-7oqfod62 35 11 , , , cord-255011-7oqfod62 35 12 which which WDT cord-255011-7oqfod62 35 13 includes include VBZ cord-255011-7oqfod62 35 14 feline feline JJ cord-255011-7oqfod62 35 15 coronavirus coronavirus NN cord-255011-7oqfod62 35 16 and and CC cord-255011-7oqfod62 35 17 porcine porcine JJ cord-255011-7oqfod62 35 18 transmissible transmissible JJ cord-255011-7oqfod62 35 19 gastroenteritis gastroenteritis NN cord-255011-7oqfod62 35 20 among among IN cord-255011-7oqfod62 35 21 others other NNS cord-255011-7oqfod62 35 22 . . . cord-255011-7oqfod62 36 1 Currently currently RB cord-255011-7oqfod62 36 2 , , , cord-255011-7oqfod62 36 3 the the DT cord-255011-7oqfod62 36 4 oldest old JJS cord-255011-7oqfod62 36 5 samples sample NNS cord-255011-7oqfod62 36 6 that that WDT cord-255011-7oqfod62 36 7 tested test VBD cord-255011-7oqfod62 36 8 positive positive JJ cord-255011-7oqfod62 36 9 for for IN cord-255011-7oqfod62 36 10 CRCoV crcov NN cord-255011-7oqfod62 36 11 are be VBP cord-255011-7oqfod62 36 12 canine canine JJ cord-255011-7oqfod62 36 13 lung lung NN cord-255011-7oqfod62 36 14 samples sample NNS cord-255011-7oqfod62 36 15 collected collect VBN cord-255011-7oqfod62 36 16 in in IN cord-255011-7oqfod62 36 17 Canada Canada NNP cord-255011-7oqfod62 36 18 in in IN cord-255011-7oqfod62 36 19 1996 1996 CD cord-255011-7oqfod62 36 20 [ [ -LRB- cord-255011-7oqfod62 36 21 12 12 CD cord-255011-7oqfod62 36 22 ] ] -RRB- cord-255011-7oqfod62 36 23 . . . cord-255011-7oqfod62 37 1 One one CD cord-255011-7oqfod62 37 2 of of IN cord-255011-7oqfod62 37 3 the the DT cord-255011-7oqfod62 37 4 reasons reason NNS cord-255011-7oqfod62 37 5 precluding preclude VBG cord-255011-7oqfod62 37 6 earlier early JJR cord-255011-7oqfod62 37 7 discovery discovery NN cord-255011-7oqfod62 37 8 of of IN cord-255011-7oqfod62 37 9 CRCoV CRCoV NNP cord-255011-7oqfod62 37 10 may may MD cord-255011-7oqfod62 37 11 be be VB cord-255011-7oqfod62 37 12 its -PRON- PRP$ cord-255011-7oqfod62 37 13 poor poor JJ cord-255011-7oqfod62 37 14 growth growth NN cord-255011-7oqfod62 37 15 in in IN cord-255011-7oqfod62 37 16 cell cell NN cord-255011-7oqfod62 37 17 culture culture NN cord-255011-7oqfod62 37 18 and and CC cord-255011-7oqfod62 37 19 the the DT cord-255011-7oqfod62 37 20 requirement requirement NN cord-255011-7oqfod62 37 21 for for IN cord-255011-7oqfod62 37 22 specific specific JJ cord-255011-7oqfod62 37 23 host host NN cord-255011-7oqfod62 37 24 cells cell NNS cord-255011-7oqfod62 37 25 . . . cord-255011-7oqfod62 38 1 The the DT cord-255011-7oqfod62 38 2 close close JJ cord-255011-7oqfod62 38 3 genetic genetic JJ cord-255011-7oqfod62 38 4 relation relation NN cord-255011-7oqfod62 38 5 to to IN cord-255011-7oqfod62 38 6 BCoV BCoV NNP cord-255011-7oqfod62 38 7 throughout throughout IN cord-255011-7oqfod62 38 8 the the DT cord-255011-7oqfod62 38 9 CRCoV crcov NN cord-255011-7oqfod62 38 10 genome genome NN cord-255011-7oqfod62 38 11 indicates indicate VBZ cord-255011-7oqfod62 38 12 that that IN cord-255011-7oqfod62 38 13 the the DT cord-255011-7oqfod62 38 14 virus virus NN cord-255011-7oqfod62 38 15 was be VBD cord-255011-7oqfod62 38 16 probably probably RB cord-255011-7oqfod62 38 17 transmitted transmit VBN cord-255011-7oqfod62 38 18 to to IN cord-255011-7oqfod62 38 19 dogs dog NNS cord-255011-7oqfod62 38 20 from from IN cord-255011-7oqfod62 38 21 cattle cattle NNS cord-255011-7oqfod62 38 22 [ [ -LRB- cord-255011-7oqfod62 38 23 13 13 CD cord-255011-7oqfod62 38 24 ] ] -RRB- cord-255011-7oqfod62 38 25 . . . cord-255011-7oqfod62 39 1 Interestingly interestingly RB cord-255011-7oqfod62 39 2 , , , cord-255011-7oqfod62 39 3 it -PRON- PRP cord-255011-7oqfod62 39 4 has have VBZ cord-255011-7oqfod62 39 5 recently recently RB cord-255011-7oqfod62 39 6 been be VBN cord-255011-7oqfod62 39 7 shown show VBN cord-255011-7oqfod62 39 8 that that IN cord-255011-7oqfod62 39 9 human human JJ cord-255011-7oqfod62 39 10 coronavirus coronavirus NN cord-255011-7oqfod62 39 11 OC43 OC43 NNP cord-255011-7oqfod62 39 12 also also RB cord-255011-7oqfod62 39 13 may may MD cord-255011-7oqfod62 39 14 have have VB cord-255011-7oqfod62 39 15 emerged emerge VBN cord-255011-7oqfod62 39 16 after after IN cord-255011-7oqfod62 39 17 viral viral JJ cord-255011-7oqfod62 39 18 transmission transmission NN cord-255011-7oqfod62 39 19 from from IN cord-255011-7oqfod62 39 20 cattle cattle NNS cord-255011-7oqfod62 39 21 to to IN cord-255011-7oqfod62 39 22 people people NNS cord-255011-7oqfod62 39 23 [ [ -LRB- cord-255011-7oqfod62 39 24 14 14 CD cord-255011-7oqfod62 39 25 ] ] -RRB- cord-255011-7oqfod62 39 26 . . . cord-255011-7oqfod62 40 1 Coronaviruses coronaviruse NNS cord-255011-7oqfod62 40 2 are be VBP cord-255011-7oqfod62 40 3 a a DT cord-255011-7oqfod62 40 4 cause cause NN cord-255011-7oqfod62 40 5 of of IN cord-255011-7oqfod62 40 6 respiratory respiratory JJ cord-255011-7oqfod62 40 7 disease disease NN cord-255011-7oqfod62 40 8 in in IN cord-255011-7oqfod62 40 9 many many JJ cord-255011-7oqfod62 40 10 species specie NNS cord-255011-7oqfod62 40 11 , , , cord-255011-7oqfod62 40 12 including include VBG cord-255011-7oqfod62 40 13 human human JJ cord-255011-7oqfod62 40 14 beings being NNS cord-255011-7oqfod62 40 15 , , , cord-255011-7oqfod62 40 16 poultry poultry NN cord-255011-7oqfod62 40 17 , , , cord-255011-7oqfod62 40 18 and and CC cord-255011-7oqfod62 40 19 cattle cattle NNS cord-255011-7oqfod62 40 20 [ [ -LRB- cord-255011-7oqfod62 40 21 15 15 CD cord-255011-7oqfod62 40 22 ] ] -RRB- cord-255011-7oqfod62 40 23 [ [ -LRB- cord-255011-7oqfod62 40 24 16 16 CD cord-255011-7oqfod62 40 25 ] ] -RRB- cord-255011-7oqfod62 40 26 [ [ -LRB- cord-255011-7oqfod62 40 27 17 17 CD cord-255011-7oqfod62 40 28 ] ] -RRB- cord-255011-7oqfod62 40 29 [ [ -LRB- cord-255011-7oqfod62 40 30 18 18 CD cord-255011-7oqfod62 40 31 ] ] -RRB- cord-255011-7oqfod62 40 32 [ [ -LRB- cord-255011-7oqfod62 40 33 19 19 CD cord-255011-7oqfod62 40 34 ] ] -RRB- cord-255011-7oqfod62 40 35 [ [ -LRB- cord-255011-7oqfod62 40 36 20 20 CD cord-255011-7oqfod62 40 37 ] ] -RRB- cord-255011-7oqfod62 40 38 . . . cord-255011-7oqfod62 41 1 The the DT cord-255011-7oqfod62 41 2 presence presence NN cord-255011-7oqfod62 41 3 of of IN cord-255011-7oqfod62 41 4 CRCoV crcov NN cord-255011-7oqfod62 41 5 in in IN cord-255011-7oqfod62 41 6 dogs dog NNS cord-255011-7oqfod62 41 7 was be VBD cord-255011-7oqfod62 41 8 first first RB cord-255011-7oqfod62 41 9 described describe VBN cord-255011-7oqfod62 41 10 in in IN cord-255011-7oqfod62 41 11 a a DT cord-255011-7oqfod62 41 12 large large JJ cord-255011-7oqfod62 41 13 study study NN cord-255011-7oqfod62 41 14 of of IN cord-255011-7oqfod62 41 15 dogs dog NNS cord-255011-7oqfod62 41 16 with with IN cord-255011-7oqfod62 41 17 CIRD CIRD NNP cord-255011-7oqfod62 41 18 [ [ -LRB- cord-255011-7oqfod62 41 19 9 9 CD cord-255011-7oqfod62 41 20 ] ] -RRB- cord-255011-7oqfod62 41 21 . . . cord-255011-7oqfod62 42 1 In in IN cord-255011-7oqfod62 42 2 this this DT cord-255011-7oqfod62 42 3 investigation investigation NN cord-255011-7oqfod62 42 4 , , , cord-255011-7oqfod62 42 5 performed perform VBN cord-255011-7oqfod62 42 6 at at IN cord-255011-7oqfod62 42 7 a a DT cord-255011-7oqfod62 42 8 shelter shelter NN cord-255011-7oqfod62 42 9 , , , cord-255011-7oqfod62 42 10 clinical clinical JJ cord-255011-7oqfod62 42 11 signs sign NNS cord-255011-7oqfod62 42 12 were be VBD cord-255011-7oqfod62 42 13 graded grade VBN cord-255011-7oqfod62 42 14 by by IN cord-255011-7oqfod62 42 15 veterinary veterinary JJ cord-255011-7oqfod62 42 16 clinicians clinician NNS cord-255011-7oqfod62 42 17 into into IN cord-255011-7oqfod62 42 18 ( ( -LRB- cord-255011-7oqfod62 42 19 1 1 LS cord-255011-7oqfod62 42 20 ) ) -RRB- cord-255011-7oqfod62 42 21 no no DT cord-255011-7oqfod62 42 22 signs sign NNS cord-255011-7oqfod62 42 23 of of IN cord-255011-7oqfod62 42 24 respiratory respiratory JJ cord-255011-7oqfod62 42 25 disease disease NN cord-255011-7oqfod62 42 26 ; ; : cord-255011-7oqfod62 42 27 ( ( -LRB- cord-255011-7oqfod62 42 28 2 2 LS cord-255011-7oqfod62 42 29 ) ) -RRB- cord-255011-7oqfod62 42 30 mild mild JJ cord-255011-7oqfod62 42 31 cough cough NN cord-255011-7oqfod62 42 32 ; ; , cord-255011-7oqfod62 42 33 ( ( -LRB- cord-255011-7oqfod62 42 34 3 3 LS cord-255011-7oqfod62 42 35 ) ) -RRB- cord-255011-7oqfod62 42 36 mild mild JJ cord-255011-7oqfod62 42 37 cough cough NN cord-255011-7oqfod62 42 38 and and CC cord-255011-7oqfod62 42 39 nasal nasal NN cord-255011-7oqfod62 42 40 discharge discharge NN cord-255011-7oqfod62 42 41 ; ; , cord-255011-7oqfod62 42 42 ( ( -LRB- cord-255011-7oqfod62 42 43 4 4 LS cord-255011-7oqfod62 42 44 ) ) -RRB- cord-255011-7oqfod62 42 45 cough cough NN cord-255011-7oqfod62 42 46 , , , cord-255011-7oqfod62 42 47 nasal nasal NN cord-255011-7oqfod62 42 48 discharge discharge NN cord-255011-7oqfod62 42 49 , , , cord-255011-7oqfod62 42 50 and and CC cord-255011-7oqfod62 42 51 inappetence inappetence NN cord-255011-7oqfod62 42 52 ; ; : cord-255011-7oqfod62 42 53 and and CC cord-255011-7oqfod62 42 54 ( ( -LRB- cord-255011-7oqfod62 42 55 5 5 LS cord-255011-7oqfod62 42 56 ) ) -RRB- cord-255011-7oqfod62 42 57 severe severe JJ cord-255011-7oqfod62 42 58 respiratory respiratory JJ cord-255011-7oqfod62 42 59 disease disease NN cord-255011-7oqfod62 42 60 with with IN cord-255011-7oqfod62 42 61 evidence evidence NN cord-255011-7oqfod62 42 62 of of IN cord-255011-7oqfod62 42 63 bronchopneumonia bronchopneumonia NN cord-255011-7oqfod62 42 64 . . . cord-255011-7oqfod62 43 1 Because because IN cord-255011-7oqfod62 43 2 of of IN cord-255011-7oqfod62 43 3 a a DT cord-255011-7oqfod62 43 4 small small JJ cord-255011-7oqfod62 43 5 number number NN cord-255011-7oqfod62 43 6 of of IN cord-255011-7oqfod62 43 7 samples sample NNS cord-255011-7oqfod62 43 8 in in IN cord-255011-7oqfod62 43 9 grade grade NN cord-255011-7oqfod62 43 10 4 4 CD cord-255011-7oqfod62 43 11 , , , cord-255011-7oqfod62 43 12 grades grade NNS cord-255011-7oqfod62 43 13 3 3 CD cord-255011-7oqfod62 43 14 and and CC cord-255011-7oqfod62 43 15 4 4 CD cord-255011-7oqfod62 43 16 were be VBD cord-255011-7oqfod62 43 17 merged merge VBN cord-255011-7oqfod62 43 18 and and CC cord-255011-7oqfod62 43 19 referred refer VBD cord-255011-7oqfod62 43 20 to to IN cord-255011-7oqfod62 43 21 as as IN cord-255011-7oqfod62 43 22 ' ' '' cord-255011-7oqfod62 43 23 ' ' `` cord-255011-7oqfod62 43 24 moderate moderate JJ cord-255011-7oqfod62 43 25 respiratory respiratory JJ cord-255011-7oqfod62 43 26 disease disease NN cord-255011-7oqfod62 43 27 . . . cord-255011-7oqfod62 43 28 ' ' '' cord-255011-7oqfod62 43 29 ' ' '' cord-255011-7oqfod62 44 1 CRCoV CRCoV NNP cord-255011-7oqfod62 44 2 was be VBD cord-255011-7oqfod62 44 3 most most RBS cord-255011-7oqfod62 44 4 frequently frequently RB cord-255011-7oqfod62 44 5 detected detect VBN cord-255011-7oqfod62 44 6 in in IN cord-255011-7oqfod62 44 7 the the DT cord-255011-7oqfod62 44 8 trachea trachea NN cord-255011-7oqfod62 44 9 of of IN cord-255011-7oqfod62 44 10 dogs dog NNS cord-255011-7oqfod62 44 11 with with IN cord-255011-7oqfod62 44 12 mild mild JJ cord-255011-7oqfod62 44 13 clinical clinical JJ cord-255011-7oqfod62 44 14 signs sign NNS cord-255011-7oqfod62 44 15 ( ( -LRB- cord-255011-7oqfod62 44 16 grade grade NN cord-255011-7oqfod62 44 17 2 2 CD cord-255011-7oqfod62 44 18 ) ) -RRB- cord-255011-7oqfod62 44 19 . . . cord-255011-7oqfod62 45 1 It -PRON- PRP cord-255011-7oqfod62 45 2 was be VBD cord-255011-7oqfod62 45 3 less less RBR cord-255011-7oqfod62 45 4 frequently frequently RB cord-255011-7oqfod62 45 5 recovered recover VBN cord-255011-7oqfod62 45 6 from from IN cord-255011-7oqfod62 45 7 dogs dog NNS cord-255011-7oqfod62 45 8 with with IN cord-255011-7oqfod62 45 9 moderate moderate JJ cord-255011-7oqfod62 45 10 or or CC cord-255011-7oqfod62 45 11 severe severe JJ cord-255011-7oqfod62 45 12 clinical clinical JJ cord-255011-7oqfod62 45 13 signs sign NNS cord-255011-7oqfod62 45 14 or or CC cord-255011-7oqfod62 45 15 from from IN cord-255011-7oqfod62 45 16 dogs dog NNS cord-255011-7oqfod62 45 17 without without IN cord-255011-7oqfod62 45 18 clinical clinical JJ cord-255011-7oqfod62 45 19 signs sign NNS cord-255011-7oqfod62 45 20 at at IN cord-255011-7oqfod62 45 21 the the DT cord-255011-7oqfod62 45 22 time time NN cord-255011-7oqfod62 45 23 of of IN cord-255011-7oqfod62 45 24 sampling sampling NN cord-255011-7oqfod62 45 25 . . . cord-255011-7oqfod62 46 1 CRCoV CRCoV NNP cord-255011-7oqfod62 46 2 was be VBD cord-255011-7oqfod62 46 3 also also RB cord-255011-7oqfod62 46 4 detected detect VBN cord-255011-7oqfod62 46 5 in in IN cord-255011-7oqfod62 46 6 the the DT cord-255011-7oqfod62 46 7 lung lung NN cord-255011-7oqfod62 46 8 , , , cord-255011-7oqfod62 46 9 albeit albeit IN cord-255011-7oqfod62 46 10 less less RBR cord-255011-7oqfod62 46 11 frequently frequently RB cord-255011-7oqfod62 46 12 . . . cord-255011-7oqfod62 47 1 Table table NN cord-255011-7oqfod62 47 2 1 1 CD cord-255011-7oqfod62 47 3 summarizes summarize VBZ cord-255011-7oqfod62 47 4 the the DT cord-255011-7oqfod62 47 5 detection detection NN cord-255011-7oqfod62 47 6 of of IN cord-255011-7oqfod62 47 7 CRCoV crcov NN cord-255011-7oqfod62 47 8 in in IN cord-255011-7oqfod62 47 9 clinical clinical JJ cord-255011-7oqfod62 47 10 samples sample NNS cord-255011-7oqfod62 47 11 from from IN cord-255011-7oqfod62 47 12 dogs dog NNS cord-255011-7oqfod62 47 13 . . . cord-255011-7oqfod62 48 1 After after IN cord-255011-7oqfod62 48 2 3 3 CD cord-255011-7oqfod62 48 3 weeks week NNS cord-255011-7oqfod62 48 4 of of IN cord-255011-7oqfod62 48 5 stay stay NN cord-255011-7oqfod62 48 6 at at IN cord-255011-7oqfod62 48 7 a a DT cord-255011-7oqfod62 48 8 shelter shelter NN cord-255011-7oqfod62 48 9 , , , cord-255011-7oqfod62 48 10 almost almost RB cord-255011-7oqfod62 48 11 100 100 CD cord-255011-7oqfod62 48 12 % % NN cord-255011-7oqfod62 48 13 of of IN cord-255011-7oqfod62 48 14 dogs dog NNS cord-255011-7oqfod62 48 15 tested test VBN cord-255011-7oqfod62 48 16 positive positive JJ cord-255011-7oqfod62 48 17 for for IN cord-255011-7oqfod62 48 18 antibodies antibody NNS cord-255011-7oqfod62 48 19 to to IN cord-255011-7oqfod62 48 20 CRCoV crcov NN cord-255011-7oqfod62 48 21 compared compare VBN cord-255011-7oqfod62 48 22 with with IN cord-255011-7oqfod62 48 23 30 30 CD cord-255011-7oqfod62 48 24 % % NN cord-255011-7oqfod62 48 25 on on IN cord-255011-7oqfod62 48 26 the the DT cord-255011-7oqfod62 48 27 day day NN cord-255011-7oqfod62 48 28 of of IN cord-255011-7oqfod62 48 29 entry entry NN cord-255011-7oqfod62 48 30 , , , cord-255011-7oqfod62 48 31 indicating indicate VBG cord-255011-7oqfod62 48 32 that that IN cord-255011-7oqfod62 48 33 the the DT cord-255011-7oqfod62 48 34 virus virus NN cord-255011-7oqfod62 48 35 was be VBD cord-255011-7oqfod62 48 36 highly highly RB cord-255011-7oqfod62 48 37 prevalent prevalent JJ cord-255011-7oqfod62 48 38 in in IN cord-255011-7oqfod62 48 39 the the DT cord-255011-7oqfod62 48 40 population population NN cord-255011-7oqfod62 48 41 and and CC cord-255011-7oqfod62 48 42 was be VBD cord-255011-7oqfod62 48 43 easily easily RB cord-255011-7oqfod62 48 44 transmitted transmit VBN cord-255011-7oqfod62 48 45 . . . cord-255011-7oqfod62 49 1 It -PRON- PRP cord-255011-7oqfod62 49 2 was be VBD cord-255011-7oqfod62 49 3 also also RB cord-255011-7oqfod62 49 4 found find VBN cord-255011-7oqfod62 49 5 that that IN cord-255011-7oqfod62 49 6 the the DT cord-255011-7oqfod62 49 7 presence presence NN cord-255011-7oqfod62 49 8 of of IN cord-255011-7oqfod62 49 9 antibodies antibody NNS cord-255011-7oqfod62 49 10 to to IN cord-255011-7oqfod62 49 11 CRCoV crcov VB cord-255011-7oqfod62 49 12 on on IN cord-255011-7oqfod62 49 13 the the DT cord-255011-7oqfod62 49 14 day day NN cord-255011-7oqfod62 49 15 of of IN cord-255011-7oqfod62 49 16 entry entry NN cord-255011-7oqfod62 49 17 led lead VBD cord-255011-7oqfod62 49 18 to to IN cord-255011-7oqfod62 49 19 a a DT cord-255011-7oqfod62 49 20 significantly significantly RB cord-255011-7oqfod62 49 21 reduced reduce VBN cord-255011-7oqfod62 49 22 risk risk NN cord-255011-7oqfod62 49 23 for for IN cord-255011-7oqfod62 49 24 contracting contract VBG cord-255011-7oqfod62 49 25 CIRD CIRD NNP cord-255011-7oqfod62 49 26 , , , cord-255011-7oqfod62 49 27 supporting support VBG cord-255011-7oqfod62 49 28 the the DT cord-255011-7oqfod62 49 29 hypothesis hypothesis NN cord-255011-7oqfod62 49 30 that that WDT cord-255011-7oqfod62 49 31 CRCoV CRCoV NNP cord-255011-7oqfod62 49 32 played play VBD cord-255011-7oqfod62 49 33 a a DT cord-255011-7oqfod62 49 34 role role NN cord-255011-7oqfod62 49 35 in in IN cord-255011-7oqfod62 49 36 the the DT cord-255011-7oqfod62 49 37 etiology etiology NN cord-255011-7oqfod62 49 38 of of IN cord-255011-7oqfod62 49 39 the the DT cord-255011-7oqfod62 49 40 disease disease NN cord-255011-7oqfod62 49 41 [ [ -LRB- cord-255011-7oqfod62 49 42 9 9 CD cord-255011-7oqfod62 49 43 ] ] -RRB- cord-255011-7oqfod62 49 44 . . . cord-255011-7oqfod62 50 1 After after IN cord-255011-7oqfod62 50 2 this this DT cord-255011-7oqfod62 50 3 initial initial JJ cord-255011-7oqfod62 50 4 investigation investigation NN cord-255011-7oqfod62 50 5 , , , cord-255011-7oqfod62 50 6 CRCoV CRCoV NNP cord-255011-7oqfod62 50 7 was be VBD cord-255011-7oqfod62 50 8 also also RB cord-255011-7oqfod62 50 9 detected detect VBN cord-255011-7oqfod62 50 10 in in IN cord-255011-7oqfod62 50 11 two two CD cord-255011-7oqfod62 50 12 UK UK NNP cord-255011-7oqfod62 50 13 training training NN cord-255011-7oqfod62 50 14 kennels kennel NNS cord-255011-7oqfod62 50 15 for for IN cord-255011-7oqfod62 50 16 working work VBG cord-255011-7oqfod62 50 17 dogs dog NNS cord-255011-7oqfod62 50 18 [ [ -LRB- cord-255011-7oqfod62 50 19 21 21 CD cord-255011-7oqfod62 50 20 ] ] -RRB- cord-255011-7oqfod62 50 21 . . . cord-255011-7oqfod62 51 1 Serum serum NN cord-255011-7oqfod62 51 2 samples sample NNS cord-255011-7oqfod62 51 3 had have VBD cord-255011-7oqfod62 51 4 been be VBN cord-255011-7oqfod62 51 5 collected collect VBN cord-255011-7oqfod62 51 6 during during IN cord-255011-7oqfod62 51 7 two two CD cord-255011-7oqfod62 51 8 outbreaks outbreak NNS cord-255011-7oqfod62 51 9 of of IN cord-255011-7oqfod62 51 10 respiratory respiratory JJ cord-255011-7oqfod62 51 11 disease disease NN cord-255011-7oqfod62 51 12 at at IN cord-255011-7oqfod62 51 13 one one CD cord-255011-7oqfod62 51 14 of of IN cord-255011-7oqfod62 51 15 the the DT cord-255011-7oqfod62 51 16 kennels kennel NNS cord-255011-7oqfod62 51 17 and and CC cord-255011-7oqfod62 51 18 4 4 CD cord-255011-7oqfod62 51 19 weeks week NNS cord-255011-7oqfod62 51 20 after after RB cord-255011-7oqfod62 51 21 . . . cord-255011-7oqfod62 52 1 Almost almost RB cord-255011-7oqfod62 52 2 all all DT cord-255011-7oqfod62 52 3 dogs dog NNS cord-255011-7oqfod62 52 4 housed house VBN cord-255011-7oqfod62 52 5 at at IN cord-255011-7oqfod62 52 6 the the DT cord-255011-7oqfod62 52 7 kennel kennel NN cord-255011-7oqfod62 52 8 showed show VBD cord-255011-7oqfod62 52 9 seroconversion seroconversion NN cord-255011-7oqfod62 52 10 to to IN cord-255011-7oqfod62 52 11 CRCoV crcov NN cord-255011-7oqfod62 52 12 after after IN cord-255011-7oqfod62 52 13 the the DT cord-255011-7oqfod62 52 14 outbreaks outbreak NNS cord-255011-7oqfod62 52 15 . . . cord-255011-7oqfod62 53 1 Moreover moreover RB cord-255011-7oqfod62 53 2 , , , cord-255011-7oqfod62 53 3 CRCoV CRCoV NNP cord-255011-7oqfod62 53 4 was be VBD cord-255011-7oqfod62 53 5 detected detect VBN cord-255011-7oqfod62 53 6 by by IN cord-255011-7oqfod62 53 7 PCR PCR NNP cord-255011-7oqfod62 53 8 in in IN cord-255011-7oqfod62 53 9 two two CD cord-255011-7oqfod62 53 10 oropharyngeal oropharyngeal JJ cord-255011-7oqfod62 53 11 swabs swab NNS cord-255011-7oqfod62 53 12 taken take VBN cord-255011-7oqfod62 53 13 from from IN cord-255011-7oqfod62 53 14 dogs dog NNS cord-255011-7oqfod62 53 15 with with IN cord-255011-7oqfod62 53 16 clinical clinical JJ cord-255011-7oqfod62 53 17 respiratory respiratory JJ cord-255011-7oqfod62 53 18 disease disease NN cord-255011-7oqfod62 53 19 . . . cord-255011-7oqfod62 54 1 Not not RB cord-255011-7oqfod62 54 2 all all DT cord-255011-7oqfod62 54 3 dogs dog NNS cord-255011-7oqfod62 54 4 that that WDT cord-255011-7oqfod62 54 5 developed develop VBD cord-255011-7oqfod62 54 6 antibodies antibody NNS cord-255011-7oqfod62 54 7 to to IN cord-255011-7oqfod62 54 8 CRCoV crcov ADD cord-255011-7oqfod62 54 9 also also RB cord-255011-7oqfod62 54 10 showed show VBD cord-255011-7oqfod62 54 11 signs sign NNS cord-255011-7oqfod62 54 12 of of IN cord-255011-7oqfod62 54 13 CIRD CIRD NNP cord-255011-7oqfod62 54 14 ; ; : cord-255011-7oqfod62 54 15 nevertheless nevertheless RB cord-255011-7oqfod62 54 16 , , , cord-255011-7oqfod62 54 17 this this DT cord-255011-7oqfod62 54 18 was be VBD cord-255011-7oqfod62 54 19 the the DT cord-255011-7oqfod62 54 20 second second JJ cord-255011-7oqfod62 54 21 study study NN cord-255011-7oqfod62 54 22 associating associate VBG cord-255011-7oqfod62 54 23 CRCoV crcov NN cord-255011-7oqfod62 54 24 with with IN cord-255011-7oqfod62 54 25 respiratory respiratory JJ cord-255011-7oqfod62 54 26 disease disease NN cord-255011-7oqfod62 54 27 in in IN cord-255011-7oqfod62 54 28 dogs dog NNS cord-255011-7oqfod62 54 29 . . . cord-255011-7oqfod62 55 1 Two two CD cord-255011-7oqfod62 55 2 further further JJ cord-255011-7oqfod62 55 3 studies study NNS cord-255011-7oqfod62 55 4 identified identify VBD cord-255011-7oqfod62 55 5 CRCoV crcov NN cord-255011-7oqfod62 55 6 in in IN cord-255011-7oqfod62 55 7 nasal nasal NN cord-255011-7oqfod62 55 8 and and CC cord-255011-7oqfod62 55 9 oral oral JJ cord-255011-7oqfod62 55 10 swabs swab NNS cord-255011-7oqfod62 55 11 from from IN cord-255011-7oqfod62 55 12 dogs dog NNS cord-255011-7oqfod62 55 13 in in IN cord-255011-7oqfod62 55 14 Japan Japan NNP cord-255011-7oqfod62 55 15 that that WDT cord-255011-7oqfod62 55 16 had have VBD cord-255011-7oqfod62 55 17 respiratory respiratory JJ cord-255011-7oqfod62 55 18 disease disease NN cord-255011-7oqfod62 55 19 [ [ -LRB- cord-255011-7oqfod62 55 20 22 22 CD cord-255011-7oqfod62 55 21 , , , cord-255011-7oqfod62 55 22 23 23 CD cord-255011-7oqfod62 55 23 ] ] -RRB- cord-255011-7oqfod62 55 24 . . . cord-255011-7oqfod62 56 1 An an DT cord-255011-7oqfod62 56 2 analysis analysis NN cord-255011-7oqfod62 56 3 of of IN cord-255011-7oqfod62 56 4 126 126 CD cord-255011-7oqfod62 56 5 archival archival JJ cord-255011-7oqfod62 56 6 tissue tissue NN cord-255011-7oqfod62 56 7 blocks block NNS cord-255011-7oqfod62 56 8 of of IN cord-255011-7oqfod62 56 9 cases case NNS cord-255011-7oqfod62 56 10 of of IN cord-255011-7oqfod62 56 11 respiratory respiratory JJ cord-255011-7oqfod62 56 12 disease disease NN cord-255011-7oqfod62 56 13 identified identify VBD cord-255011-7oqfod62 56 14 two two CD cord-255011-7oqfod62 56 15 CRCoV crcov NN cord-255011-7oqfod62 56 16 - - HYPH cord-255011-7oqfod62 56 17 positive positive JJ cord-255011-7oqfod62 56 18 samples sample NNS cord-255011-7oqfod62 56 19 by by IN cord-255011-7oqfod62 56 20 immunohistochemistry immunohistochemistry NN cord-255011-7oqfod62 56 21 . . . cord-255011-7oqfod62 57 1 Both both DT cord-255011-7oqfod62 57 2 were be VBD cord-255011-7oqfod62 57 3 from from IN cord-255011-7oqfod62 57 4 dogs dog NNS cord-255011-7oqfod62 57 5 with with IN cord-255011-7oqfod62 57 6 bronchitis bronchitis NN cord-255011-7oqfod62 57 7 and and CC cord-255011-7oqfod62 57 8 bronchiolitis bronchiolitis NN cord-255011-7oqfod62 57 9 , , , cord-255011-7oqfod62 57 10 and and CC cord-255011-7oqfod62 57 11 CRCoV crcov NN cord-255011-7oqfod62 57 12 antigen antigen NN cord-255011-7oqfod62 57 13 was be VBD cord-255011-7oqfod62 57 14 found find VBN cord-255011-7oqfod62 57 15 to to TO cord-255011-7oqfod62 57 16 be be VB cord-255011-7oqfod62 57 17 present present JJ cord-255011-7oqfod62 57 18 in in IN cord-255011-7oqfod62 57 19 respiratory respiratory JJ cord-255011-7oqfod62 57 20 columnar columnar JJ cord-255011-7oqfod62 57 21 epithelial epithelial JJ cord-255011-7oqfod62 57 22 cells cell NNS cord-255011-7oqfod62 57 23 . . . cord-255011-7oqfod62 58 1 One one CD cord-255011-7oqfod62 58 2 of of IN cord-255011-7oqfod62 58 3 those those DT cord-255011-7oqfod62 58 4 dogs dog NNS cord-255011-7oqfod62 58 5 was be VBD cord-255011-7oqfod62 58 6 also also RB cord-255011-7oqfod62 58 7 positive positive JJ cord-255011-7oqfod62 58 8 for for IN cord-255011-7oqfod62 58 9 canine canine JJ cord-255011-7oqfod62 58 10 distemper distemper NN cord-255011-7oqfod62 58 11 virus virus NN cord-255011-7oqfod62 58 12 [ [ -LRB- cord-255011-7oqfod62 58 13 12 12 CD cord-255011-7oqfod62 58 14 ] ] -RRB- cord-255011-7oqfod62 58 15 . . . cord-255011-7oqfod62 59 1 The the DT cord-255011-7oqfod62 59 2 detection detection NN cord-255011-7oqfod62 59 3 rate rate NN cord-255011-7oqfod62 59 4 of of IN cord-255011-7oqfod62 59 5 CRCoV crcov NN cord-255011-7oqfod62 59 6 in in IN cord-255011-7oqfod62 59 7 the the DT cord-255011-7oqfod62 59 8 archival archival JJ cord-255011-7oqfod62 59 9 study study NN cord-255011-7oqfod62 59 10 may may MD cord-255011-7oqfod62 59 11 seem seem VB cord-255011-7oqfod62 59 12 quite quite RB cord-255011-7oqfod62 59 13 low low JJ cord-255011-7oqfod62 59 14 ; ; : cord-255011-7oqfod62 59 15 however however RB cord-255011-7oqfod62 59 16 , , , cord-255011-7oqfod62 59 17 the the DT cord-255011-7oqfod62 59 18 tissue tissue NN cord-255011-7oqfod62 59 19 samples sample NNS cord-255011-7oqfod62 59 20 were be VBD cord-255011-7oqfod62 59 21 mostly mostly RB cord-255011-7oqfod62 59 22 derived derive VBN cord-255011-7oqfod62 59 23 from from IN cord-255011-7oqfod62 59 24 dogs dog NNS cord-255011-7oqfod62 59 25 with with IN cord-255011-7oqfod62 59 26 severe severe JJ cord-255011-7oqfod62 59 27 respiratory respiratory JJ cord-255011-7oqfod62 59 28 disease disease NN cord-255011-7oqfod62 59 29 with with IN cord-255011-7oqfod62 59 30 a a DT cord-255011-7oqfod62 59 31 fatal fatal JJ cord-255011-7oqfod62 59 32 outcome outcome NN cord-255011-7oqfod62 59 33 , , , cord-255011-7oqfod62 59 34 whereas whereas IN cord-255011-7oqfod62 59 35 CRCoV CRCoV NNP cord-255011-7oqfod62 59 36 has have VBZ cord-255011-7oqfod62 59 37 mostly mostly RB cord-255011-7oqfod62 59 38 been be VBN cord-255011-7oqfod62 59 39 associated associate VBN cord-255011-7oqfod62 59 40 with with IN cord-255011-7oqfod62 59 41 mild mild JJ cord-255011-7oqfod62 59 42 respiratory respiratory JJ cord-255011-7oqfod62 59 43 disease disease NN cord-255011-7oqfod62 59 44 so so RB cord-255011-7oqfod62 59 45 far far RB cord-255011-7oqfod62 59 46 . . . cord-255011-7oqfod62 60 1 Serologic Serologic NNP cord-255011-7oqfod62 60 2 studies study NNS cord-255011-7oqfod62 60 3 to to TO cord-255011-7oqfod62 60 4 determine determine VB cord-255011-7oqfod62 60 5 the the DT cord-255011-7oqfod62 60 6 prevalence prevalence NN cord-255011-7oqfod62 60 7 of of IN cord-255011-7oqfod62 60 8 antibodies antibody NNS cord-255011-7oqfod62 60 9 to to IN cord-255011-7oqfod62 60 10 CRCoV crcov NN cord-255011-7oqfod62 60 11 have have VBP cord-255011-7oqfod62 60 12 been be VBN cord-255011-7oqfod62 60 13 performed perform VBN cord-255011-7oqfod62 60 14 to to IN cord-255011-7oqfod62 60 15 date date NN cord-255011-7oqfod62 60 16 for for IN cord-255011-7oqfod62 60 17 the the DT cord-255011-7oqfod62 60 18 United United NNP cord-255011-7oqfod62 60 19 Kingdom Kingdom NNP cord-255011-7oqfod62 60 20 , , , cord-255011-7oqfod62 60 21 Republic Republic NNP cord-255011-7oqfod62 60 22 of of IN cord-255011-7oqfod62 60 23 Ireland Ireland NNP cord-255011-7oqfod62 60 24 , , , cord-255011-7oqfod62 60 25 Italy Italy NNP cord-255011-7oqfod62 60 26 , , , cord-255011-7oqfod62 60 27 United United NNP cord-255011-7oqfod62 60 28 States States NNP cord-255011-7oqfod62 60 29 , , , cord-255011-7oqfod62 60 30 Canada Canada NNP cord-255011-7oqfod62 60 31 , , , cord-255011-7oqfod62 60 32 and and CC cord-255011-7oqfod62 60 33 Japan Japan NNP cord-255011-7oqfod62 60 34 . . . cord-255011-7oqfod62 61 1 The the DT cord-255011-7oqfod62 61 2 highest high JJS cord-255011-7oqfod62 61 3 seroprevalence seroprevalence NN cord-255011-7oqfod62 61 4 was be VBD cord-255011-7oqfod62 61 5 detected detect VBN cord-255011-7oqfod62 61 6 in in IN cord-255011-7oqfod62 61 7 Canada Canada NNP cord-255011-7oqfod62 61 8 ( ( -LRB- cord-255011-7oqfod62 61 9 59.1 59.1 CD cord-255011-7oqfod62 61 10 % % NN cord-255011-7oqfod62 61 11 of of IN cord-255011-7oqfod62 61 12 sera sera NNP cord-255011-7oqfod62 61 13 tested test VBN cord-255011-7oqfod62 61 14 were be VBD cord-255011-7oqfod62 61 15 found find VBN cord-255011-7oqfod62 61 16 to to TO cord-255011-7oqfod62 61 17 be be VB cord-255011-7oqfod62 61 18 positive positive JJ cord-255011-7oqfod62 61 19 ) ) -RRB- cord-255011-7oqfod62 61 20 and and CC cord-255011-7oqfod62 61 21 the the DT cord-255011-7oqfod62 61 22 United United NNP cord-255011-7oqfod62 61 23 States States NNP cord-255011-7oqfod62 61 24 ( ( -LRB- cord-255011-7oqfod62 61 25 54.7 54.7 CD cord-255011-7oqfod62 61 26 % % NN cord-255011-7oqfod62 61 27 of of IN cord-255011-7oqfod62 61 28 sera sera NNP cord-255011-7oqfod62 61 29 tested test VBN cord-255011-7oqfod62 61 30 were be VBD cord-255011-7oqfod62 61 31 found find VBN cord-255011-7oqfod62 61 32 to to TO cord-255011-7oqfod62 61 33 be be VB cord-255011-7oqfod62 61 34 positive positive JJ cord-255011-7oqfod62 61 35 ) ) -RRB- cord-255011-7oqfod62 61 36 . . . cord-255011-7oqfod62 62 1 Samples sample NNS cord-255011-7oqfod62 62 2 from from IN cord-255011-7oqfod62 62 3 the the DT cord-255011-7oqfod62 62 4 United United NNP cord-255011-7oqfod62 62 5 States States NNP cord-255011-7oqfod62 62 6 had have VBD cord-255011-7oqfod62 62 7 been be VBN cord-255011-7oqfod62 62 8 collected collect VBN cord-255011-7oqfod62 62 9 from from IN cord-255011-7oqfod62 62 10 33 33 CD cord-255011-7oqfod62 62 11 states state NNS cord-255011-7oqfod62 62 12 , , , cord-255011-7oqfod62 62 13 and and CC cord-255011-7oqfod62 62 14 positive positive JJ cord-255011-7oqfod62 62 15 samples sample NNS cord-255011-7oqfod62 62 16 were be VBD cord-255011-7oqfod62 62 17 identified identify VBN cord-255011-7oqfod62 62 18 in in IN cord-255011-7oqfod62 62 19 29 29 CD cord-255011-7oqfod62 62 20 [ [ -LRB- cord-255011-7oqfod62 62 21 24 24 CD cord-255011-7oqfod62 62 22 ] ] -RRB- cord-255011-7oqfod62 62 23 . . . cord-255011-7oqfod62 63 1 In in IN cord-255011-7oqfod62 63 2 those those DT cord-255011-7oqfod62 63 3 states state NNS cord-255011-7oqfod62 63 4 that that WDT cord-255011-7oqfod62 63 5 allowed allow VBD cord-255011-7oqfod62 63 6 a a DT cord-255011-7oqfod62 63 7 meaningful meaningful JJ cord-255011-7oqfod62 63 8 interpretation interpretation NN cord-255011-7oqfod62 63 9 of of IN cord-255011-7oqfod62 63 10 seroprevalence seroprevalence NN cord-255011-7oqfod62 63 11 ( ( -LRB- cord-255011-7oqfod62 63 12 more more JJR cord-255011-7oqfod62 63 13 than than IN cord-255011-7oqfod62 63 14 10 10 CD cord-255011-7oqfod62 63 15 samples sample NNS cord-255011-7oqfod62 63 16 ) ) -RRB- cord-255011-7oqfod62 63 17 , , , cord-255011-7oqfod62 63 18 the the DT cord-255011-7oqfod62 63 19 prevalence prevalence NN cord-255011-7oqfod62 63 20 ranged range VBD cord-255011-7oqfod62 63 21 from from IN cord-255011-7oqfod62 63 22 31.3 31.3 CD cord-255011-7oqfod62 63 23 % % NN cord-255011-7oqfod62 63 24 ( ( -LRB- cord-255011-7oqfod62 63 25 Maine Maine NNP cord-255011-7oqfod62 63 26 ) ) -RRB- cord-255011-7oqfod62 63 27 to to IN cord-255011-7oqfod62 63 28 87.5 87.5 CD cord-255011-7oqfod62 63 29 % % NN cord-255011-7oqfod62 63 30 ( ( -LRB- cord-255011-7oqfod62 63 31 Kentucky Kentucky NNP cord-255011-7oqfod62 63 32 ) ) -RRB- cord-255011-7oqfod62 63 33 . . . cord-255011-7oqfod62 64 1 The the DT cord-255011-7oqfod62 64 2 prevalence prevalence NN cord-255011-7oqfod62 64 3 in in IN cord-255011-7oqfod62 64 4 the the DT cord-255011-7oqfod62 64 5 United United NNP cord-255011-7oqfod62 64 6 Kingdom Kingdom NNP cord-255011-7oqfod62 64 7 and and CC cord-255011-7oqfod62 64 8 the the DT cord-255011-7oqfod62 64 9 Republic Republic NNP cord-255011-7oqfod62 64 10 of of IN cord-255011-7oqfod62 64 11 Ireland Ireland NNP cord-255011-7oqfod62 64 12 was be VBD cord-255011-7oqfod62 64 13 lower low JJR cord-255011-7oqfod62 64 14 , , , cord-255011-7oqfod62 64 15 with with IN cord-255011-7oqfod62 64 16 36 36 CD cord-255011-7oqfod62 64 17 % % NN cord-255011-7oqfod62 64 18 and and CC cord-255011-7oqfod62 64 19 30.3 30.3 CD cord-255011-7oqfod62 64 20 % % NN cord-255011-7oqfod62 64 21 , , , cord-255011-7oqfod62 64 22 respectively respectively RB cord-255011-7oqfod62 64 23 [ [ -LRB- cord-255011-7oqfod62 64 24 24 24 CD cord-255011-7oqfod62 64 25 ] ] -RRB- cord-255011-7oqfod62 64 26 . . . cord-255011-7oqfod62 65 1 Two two CD cord-255011-7oqfod62 65 2 studies study NNS cord-255011-7oqfod62 65 3 performed perform VBN cord-255011-7oqfod62 65 4 in in IN cord-255011-7oqfod62 65 5 Italy Italy NNP cord-255011-7oqfod62 65 6 showed show VBD cord-255011-7oqfod62 65 7 seroprevalence seroprevalence NN cord-255011-7oqfod62 65 8 ranging range VBG cord-255011-7oqfod62 65 9 from from IN cord-255011-7oqfod62 65 10 20 20 CD cord-255011-7oqfod62 65 11 % % NN cord-255011-7oqfod62 65 12 to to IN cord-255011-7oqfod62 65 13 32.5 32.5 CD cord-255011-7oqfod62 65 14 % % NN cord-255011-7oqfod62 65 15 [ [ -LRB- cord-255011-7oqfod62 65 16 25 25 CD cord-255011-7oqfod62 65 17 , , , cord-255011-7oqfod62 65 18 26 26 CD cord-255011-7oqfod62 65 19 ] ] -RRB- cord-255011-7oqfod62 65 20 . . . cord-255011-7oqfod62 66 1 The the DT cord-255011-7oqfod62 66 2 lowest low JJS cord-255011-7oqfod62 66 3 seroprevalence seroprevalence NN cord-255011-7oqfod62 66 4 was be VBD cord-255011-7oqfod62 66 5 detected detect VBN cord-255011-7oqfod62 66 6 in in IN cord-255011-7oqfod62 66 7 Japan Japan NNP cord-255011-7oqfod62 66 8 , , , cord-255011-7oqfod62 66 9 with with IN cord-255011-7oqfod62 66 10 17.8 17.8 CD cord-255011-7oqfod62 66 11 % % NN cord-255011-7oqfod62 66 12 [ [ -LRB- cord-255011-7oqfod62 66 13 23 23 CD cord-255011-7oqfod62 66 14 ] ] -RRB- cord-255011-7oqfod62 66 15 . . . cord-255011-7oqfod62 67 1 Further further JJ cord-255011-7oqfod62 67 2 data datum NNS cord-255011-7oqfod62 67 3 are be VBP cord-255011-7oqfod62 67 4 not not RB cord-255011-7oqfod62 67 5 yet yet RB cord-255011-7oqfod62 67 6 available available JJ cord-255011-7oqfod62 67 7 , , , cord-255011-7oqfod62 67 8 but but CC cord-255011-7oqfod62 67 9 it -PRON- PRP cord-255011-7oqfod62 67 10 is be VBZ cord-255011-7oqfod62 67 11 likely likely JJ cord-255011-7oqfod62 67 12 that that IN cord-255011-7oqfod62 67 13 CRCoV crcov NN cord-255011-7oqfod62 67 14 is be VBZ cord-255011-7oqfod62 67 15 present present JJ cord-255011-7oqfod62 67 16 throughout throughout IN cord-255011-7oqfod62 67 17 the the DT cord-255011-7oqfod62 67 18 United United NNP cord-255011-7oqfod62 67 19 States States NNP cord-255011-7oqfod62 67 20 and and CC cord-255011-7oqfod62 67 21 in in IN cord-255011-7oqfod62 67 22 other other JJ cord-255011-7oqfod62 67 23 European european JJ cord-255011-7oqfod62 67 24 countries country NNS cord-255011-7oqfod62 67 25 . . . cord-255011-7oqfod62 68 1 Although although IN cord-255011-7oqfod62 68 2 CRCoV CRCoV NNP cord-255011-7oqfod62 68 3 was be VBD cord-255011-7oqfod62 68 4 detected detect VBN cord-255011-7oqfod62 68 5 throughout throughout IN cord-255011-7oqfod62 68 6 the the DT cord-255011-7oqfod62 68 7 year year NN cord-255011-7oqfod62 68 8 in in IN cord-255011-7oqfod62 68 9 a a DT cord-255011-7oqfod62 68 10 kennel kennel NN cord-255011-7oqfod62 68 11 with with IN cord-255011-7oqfod62 68 12 enzootic enzootic JJ cord-255011-7oqfod62 68 13 CIRD CIRD NNP cord-255011-7oqfod62 68 14 , , , cord-255011-7oqfod62 68 15 another another DT cord-255011-7oqfod62 68 16 study study NN cord-255011-7oqfod62 68 17 reported report VBD cord-255011-7oqfod62 68 18 a a DT cord-255011-7oqfod62 68 19 seasonal seasonal JJ cord-255011-7oqfod62 68 20 occurrence occurrence NN cord-255011-7oqfod62 68 21 of of IN cord-255011-7oqfod62 68 22 the the DT cord-255011-7oqfod62 68 23 virus virus NN cord-255011-7oqfod62 68 24 in in IN cord-255011-7oqfod62 68 25 the the DT cord-255011-7oqfod62 68 26 winter winter NN cord-255011-7oqfod62 68 27 months month NNS cord-255011-7oqfod62 68 28 . . . cord-255011-7oqfod62 69 1 No no DT cord-255011-7oqfod62 69 2 seroconversions seroconversion NNS cord-255011-7oqfod62 69 3 to to IN cord-255011-7oqfod62 69 4 CRCoV crcov NN cord-255011-7oqfod62 69 5 and and CC cord-255011-7oqfod62 69 6 few few JJ cord-255011-7oqfod62 69 7 cases case NNS cord-255011-7oqfod62 69 8 of of IN cord-255011-7oqfod62 69 9 respiratory respiratory JJ cord-255011-7oqfod62 69 10 disease disease NN cord-255011-7oqfod62 69 11 were be VBD cord-255011-7oqfod62 69 12 recorded record VBN cord-255011-7oqfod62 69 13 in in IN cord-255011-7oqfod62 69 14 the the DT cord-255011-7oqfod62 69 15 summer summer NN cord-255011-7oqfod62 69 16 months month NNS cord-255011-7oqfod62 69 17 [ [ -LRB- cord-255011-7oqfod62 69 18 21 21 CD cord-255011-7oqfod62 69 19 ] ] -RRB- cord-255011-7oqfod62 69 20 . . . cord-255011-7oqfod62 70 1 A a DT cord-255011-7oqfod62 70 2 similar similar JJ cord-255011-7oqfod62 70 3 seasonality seasonality NN cord-255011-7oqfod62 70 4 has have VBZ cord-255011-7oqfod62 70 5 been be VBN cord-255011-7oqfod62 70 6 reported report VBN cord-255011-7oqfod62 70 7 for for IN cord-255011-7oqfod62 70 8 human human JJ cord-255011-7oqfod62 70 9 coronaviruses coronaviruse NNS cord-255011-7oqfod62 70 10 involved involve VBN cord-255011-7oqfod62 70 11 in in IN cord-255011-7oqfod62 70 12 the the DT cord-255011-7oqfod62 70 13 common common JJ cord-255011-7oqfod62 70 14 cold cold NN cord-255011-7oqfod62 70 15 [ [ -LRB- cord-255011-7oqfod62 70 16 27 27 CD cord-255011-7oqfod62 70 17 ] ] -RRB- cord-255011-7oqfod62 70 18 . . . cord-255011-7oqfod62 71 1 CRCoV crcov NN cord-255011-7oqfod62 71 2 infections infection NNS cord-255011-7oqfod62 71 3 can can MD cord-255011-7oqfod62 71 4 occur occur VB cord-255011-7oqfod62 71 5 in in IN cord-255011-7oqfod62 71 6 dogs dog NNS cord-255011-7oqfod62 71 7 of of IN cord-255011-7oqfod62 71 8 all all DT cord-255011-7oqfod62 71 9 ages age NNS cord-255011-7oqfod62 71 10 . . . cord-255011-7oqfod62 72 1 Dogs dog NNS cord-255011-7oqfod62 72 2 younger young JJR cord-255011-7oqfod62 72 3 than than IN cord-255011-7oqfod62 72 4 1 1 CD cord-255011-7oqfod62 72 5 year year NN cord-255011-7oqfod62 72 6 of of IN cord-255011-7oqfod62 72 7 age age NN cord-255011-7oqfod62 72 8 were be VBD cord-255011-7oqfod62 72 9 significantly significantly RB cord-255011-7oqfod62 72 10 more more RBR cord-255011-7oqfod62 72 11 likely likely JJ cord-255011-7oqfod62 72 12 to to TO cord-255011-7oqfod62 72 13 be be VB cord-255011-7oqfod62 72 14 seronegative seronegative JJ cord-255011-7oqfod62 72 15 than than IN cord-255011-7oqfod62 72 16 older old JJR cord-255011-7oqfod62 72 17 dogs dog NNS cord-255011-7oqfod62 72 18 , , , cord-255011-7oqfod62 72 19 however however RB cord-255011-7oqfod62 72 20 [ [ -LRB- cord-255011-7oqfod62 72 21 24 24 CD cord-255011-7oqfod62 72 22 , , , cord-255011-7oqfod62 72 23 25 25 CD cord-255011-7oqfod62 72 24 ] ] -RRB- cord-255011-7oqfod62 72 25 . . . cord-255011-7oqfod62 73 1 This this DT cord-255011-7oqfod62 73 2 is be VBZ cord-255011-7oqfod62 73 3 in in IN cord-255011-7oqfod62 73 4 contrast contrast NN cord-255011-7oqfod62 73 5 to to IN cord-255011-7oqfod62 73 6 the the DT cord-255011-7oqfod62 73 7 prevalence prevalence NN cord-255011-7oqfod62 73 8 of of IN cord-255011-7oqfod62 73 9 enteric enteric JJ cord-255011-7oqfod62 73 10 CCoV CCoV NNP cord-255011-7oqfod62 73 11 , , , cord-255011-7oqfod62 73 12 which which WDT cord-255011-7oqfod62 73 13 is be VBZ cord-255011-7oqfod62 73 14 frequently frequently RB cord-255011-7oqfod62 73 15 found find VBN cord-255011-7oqfod62 73 16 in in IN cord-255011-7oqfod62 73 17 dogs dog NNS cord-255011-7oqfod62 73 18 younger young JJR cord-255011-7oqfod62 73 19 than than IN cord-255011-7oqfod62 73 20 1 1 CD cord-255011-7oqfod62 73 21 year year NN cord-255011-7oqfod62 73 22 of of IN cord-255011-7oqfod62 73 23 age age NN cord-255011-7oqfod62 73 24 [ [ -LRB- cord-255011-7oqfod62 73 25 10 10 CD cord-255011-7oqfod62 73 26 ] ] -RRB- cord-255011-7oqfod62 73 27 . . . cord-255011-7oqfod62 74 1 This this DT cord-255011-7oqfod62 74 2 may may MD cord-255011-7oqfod62 74 3 reflect reflect VB cord-255011-7oqfod62 74 4 different different JJ cord-255011-7oqfod62 74 5 patterns pattern NNS cord-255011-7oqfod62 74 6 of of IN cord-255011-7oqfod62 74 7 transmission transmission NN cord-255011-7oqfod62 74 8 of of IN cord-255011-7oqfod62 74 9 the the DT cord-255011-7oqfod62 74 10 two two CD cord-255011-7oqfod62 74 11 viruses virus NNS cord-255011-7oqfod62 74 12 . . . cord-255011-7oqfod62 75 1 The the DT cord-255011-7oqfod62 75 2 seroprevalence seroprevalence NN cord-255011-7oqfod62 75 3 of of IN cord-255011-7oqfod62 75 4 CRCoV CRCoV NNP cord-255011-7oqfod62 75 5 was be VBD cord-255011-7oqfod62 75 6 increasing increase VBG cord-255011-7oqfod62 75 7 after after IN cord-255011-7oqfod62 75 8 the the DT cord-255011-7oqfod62 75 9 age age NN cord-255011-7oqfod62 75 10 of of IN cord-255011-7oqfod62 75 11 1 1 CD cord-255011-7oqfod62 75 12 year year NN cord-255011-7oqfod62 75 13 for for IN cord-255011-7oqfod62 75 14 all all DT cord-255011-7oqfod62 75 15 studies study NNS cord-255011-7oqfod62 75 16 and and CC cord-255011-7oqfod62 75 17 then then RB cord-255011-7oqfod62 75 18 reached reach VBD cord-255011-7oqfod62 75 19 a a DT cord-255011-7oqfod62 75 20 plateau plateau NN cord-255011-7oqfod62 75 21 between between IN cord-255011-7oqfod62 75 22 the the DT cord-255011-7oqfod62 75 23 ages age NNS cord-255011-7oqfod62 75 24 of of IN cord-255011-7oqfod62 75 25 2 2 CD cord-255011-7oqfod62 75 26 and and CC cord-255011-7oqfod62 75 27 approximately approximately RB cord-255011-7oqfod62 75 28 8 8 CD cord-255011-7oqfod62 75 29 years year NNS cord-255011-7oqfod62 75 30 . . . cord-255011-7oqfod62 76 1 This this DT cord-255011-7oqfod62 76 2 is be VBZ cord-255011-7oqfod62 76 3 probably probably RB cord-255011-7oqfod62 76 4 a a DT cord-255011-7oqfod62 76 5 consequence consequence NN cord-255011-7oqfod62 76 6 of of IN cord-255011-7oqfod62 76 7 the the DT cord-255011-7oqfod62 76 8 greater great JJR cord-255011-7oqfod62 76 9 probability probability NN cord-255011-7oqfod62 76 10 of of IN cord-255011-7oqfod62 76 11 exposure exposure NN cord-255011-7oqfod62 76 12 to to IN cord-255011-7oqfod62 76 13 the the DT cord-255011-7oqfod62 76 14 virus virus NN cord-255011-7oqfod62 76 15 with with IN cord-255011-7oqfod62 76 16 increasing increase VBG cord-255011-7oqfod62 76 17 contact contact NN cord-255011-7oqfod62 76 18 with with IN cord-255011-7oqfod62 76 19 other other JJ cord-255011-7oqfod62 76 20 dogs dog NNS cord-255011-7oqfod62 76 21 . . . cord-255011-7oqfod62 77 1 It -PRON- PRP cord-255011-7oqfod62 77 2 is be VBZ cord-255011-7oqfod62 77 3 not not RB cord-255011-7oqfod62 77 4 certain certain JJ cord-255011-7oqfod62 77 5 how how WRB cord-255011-7oqfod62 77 6 long long JJ cord-255011-7oqfod62 77 7 CRCoV crcov NN cord-255011-7oqfod62 77 8 antibody antibody NN cord-255011-7oqfod62 77 9 levels level NNS cord-255011-7oqfod62 77 10 in in IN cord-255011-7oqfod62 77 11 dogs dog NNS cord-255011-7oqfod62 77 12 remain remain VBP cord-255011-7oqfod62 77 13 stable stable JJ cord-255011-7oqfod62 77 14 after after IN cord-255011-7oqfod62 77 15 infection infection NN cord-255011-7oqfod62 77 16 . . . cord-255011-7oqfod62 78 1 One one CD cord-255011-7oqfod62 78 2 study study NN cord-255011-7oqfod62 78 3 showed show VBD cord-255011-7oqfod62 78 4 a a DT cord-255011-7oqfod62 78 5 twofold twofold JJ cord-255011-7oqfod62 78 6 decrease decrease NN cord-255011-7oqfod62 78 7 in in IN cord-255011-7oqfod62 78 8 antibody antibody NN cord-255011-7oqfod62 78 9 titers titer NNS cord-255011-7oqfod62 78 10 in in IN cord-255011-7oqfod62 78 11 6 6 CD cord-255011-7oqfod62 78 12 of of IN cord-255011-7oqfod62 78 13 14 14 CD cord-255011-7oqfod62 78 14 dogs dog NNS cord-255011-7oqfod62 78 15 tested test VBN cord-255011-7oqfod62 78 16 and and CC cord-255011-7oqfod62 78 17 a a DT cord-255011-7oqfod62 78 18 fourfold fourfold JJ cord-255011-7oqfod62 78 19 decrease decrease NN cord-255011-7oqfod62 78 20 in in IN cord-255011-7oqfod62 78 21 4 4 CD cord-255011-7oqfod62 78 22 dogs dog NNS cord-255011-7oqfod62 78 23 in in IN cord-255011-7oqfod62 78 24 less less JJR cord-255011-7oqfod62 78 25 than than IN cord-255011-7oqfod62 78 26 1 1 CD cord-255011-7oqfod62 78 27 year year NN cord-255011-7oqfod62 78 28 [ [ -LRB- cord-255011-7oqfod62 78 29 21 21 CD cord-255011-7oqfod62 78 30 ] ] -RRB- cord-255011-7oqfod62 78 31 . . . cord-255011-7oqfod62 79 1 Because because IN cord-255011-7oqfod62 79 2 these these DT cord-255011-7oqfod62 79 3 were be VBD cord-255011-7oqfod62 79 4 naturally naturally RB cord-255011-7oqfod62 79 5 occurring occur VBG cord-255011-7oqfod62 79 6 infections infection NNS cord-255011-7oqfod62 79 7 , , , cord-255011-7oqfod62 79 8 it -PRON- PRP cord-255011-7oqfod62 79 9 is be VBZ cord-255011-7oqfod62 79 10 not not RB cord-255011-7oqfod62 79 11 known know VBN cord-255011-7oqfod62 79 12 if if IN cord-255011-7oqfod62 79 13 the the DT cord-255011-7oqfod62 79 14 antibody antibody NN cord-255011-7oqfod62 79 15 response response NN cord-255011-7oqfod62 79 16 measured measure VBN cord-255011-7oqfod62 79 17 reflected reflect VBD cord-255011-7oqfod62 79 18 primary primary JJ cord-255011-7oqfod62 79 19 or or CC cord-255011-7oqfod62 79 20 repeated repeat VBN cord-255011-7oqfod62 79 21 infections infection NNS cord-255011-7oqfod62 79 22 . . . cord-255011-7oqfod62 80 1 The the DT cord-255011-7oqfod62 80 2 viral viral JJ cord-255011-7oqfod62 80 3 dose dose NN cord-255011-7oqfod62 80 4 encountered encounter VBN cord-255011-7oqfod62 80 5 by by IN cord-255011-7oqfod62 80 6 dogs dog NNS cord-255011-7oqfod62 80 7 would would MD cord-255011-7oqfod62 80 8 also also RB cord-255011-7oqfod62 80 9 influence influence VB cord-255011-7oqfod62 80 10 the the DT cord-255011-7oqfod62 80 11 level level NN cord-255011-7oqfod62 80 12 and and CC cord-255011-7oqfod62 80 13 duration duration NN cord-255011-7oqfod62 80 14 of of IN cord-255011-7oqfod62 80 15 the the DT cord-255011-7oqfod62 80 16 antibody antibody NN cord-255011-7oqfod62 80 17 response response NN cord-255011-7oqfod62 80 18 . . . cord-255011-7oqfod62 81 1 The the DT cord-255011-7oqfod62 81 2 rapid rapid JJ cord-255011-7oqfod62 81 3 spread spread NN cord-255011-7oqfod62 81 4 of of IN cord-255011-7oqfod62 81 5 CRCoV crcov NN cord-255011-7oqfod62 81 6 through through IN cord-255011-7oqfod62 81 7 kenneled kennel VBN cord-255011-7oqfod62 81 8 populations population NNS cord-255011-7oqfod62 81 9 indicates indicate VBZ cord-255011-7oqfod62 81 10 that that IN cord-255011-7oqfod62 81 11 the the DT cord-255011-7oqfod62 81 12 virus virus NN cord-255011-7oqfod62 81 13 is be VBZ cord-255011-7oqfod62 81 14 highly highly RB cord-255011-7oqfod62 81 15 contagious contagious JJ cord-255011-7oqfod62 81 16 . . . cord-255011-7oqfod62 82 1 This this DT cord-255011-7oqfod62 82 2 , , , cord-255011-7oqfod62 82 3 in in IN cord-255011-7oqfod62 82 4 conjunction conjunction NN cord-255011-7oqfod62 82 5 with with IN cord-255011-7oqfod62 82 6 the the DT cord-255011-7oqfod62 82 7 predominant predominant JJ cord-255011-7oqfod62 82 8 detection detection NN cord-255011-7oqfod62 82 9 of of IN cord-255011-7oqfod62 82 10 CRCoV crcov NN cord-255011-7oqfod62 82 11 in in IN cord-255011-7oqfod62 82 12 respiratory respiratory JJ cord-255011-7oqfod62 82 13 samples sample NNS cord-255011-7oqfod62 82 14 , , , cord-255011-7oqfod62 82 15 suggests suggest VBZ cord-255011-7oqfod62 82 16 that that IN cord-255011-7oqfod62 82 17 it -PRON- PRP cord-255011-7oqfod62 82 18 is be VBZ cord-255011-7oqfod62 82 19 mostly mostly RB cord-255011-7oqfod62 82 20 spread spread VBN cord-255011-7oqfod62 82 21 by by IN cord-255011-7oqfod62 82 22 means mean NNS cord-255011-7oqfod62 82 23 of of IN cord-255011-7oqfod62 82 24 respiratory respiratory JJ cord-255011-7oqfod62 82 25 secretions secretion NNS cord-255011-7oqfod62 82 26 . . . cord-255011-7oqfod62 83 1 CRCoV CRCoV NNP cord-255011-7oqfod62 83 2 probably probably RB cord-255011-7oqfod62 83 3 enters enter VBZ cord-255011-7oqfod62 83 4 the the DT cord-255011-7oqfod62 83 5 respiratory respiratory JJ cord-255011-7oqfod62 83 6 tract tract NN cord-255011-7oqfod62 83 7 by by IN cord-255011-7oqfod62 83 8 inhalation inhalation NN cord-255011-7oqfod62 83 9 of of IN cord-255011-7oqfod62 83 10 droplets droplet NNS cord-255011-7oqfod62 83 11 or or CC cord-255011-7oqfod62 83 12 contact contact NN cord-255011-7oqfod62 83 13 with with IN cord-255011-7oqfod62 83 14 secretions secretion NNS cord-255011-7oqfod62 83 15 and and CC cord-255011-7oqfod62 83 16 contaminated contaminated JJ cord-255011-7oqfod62 83 17 surfaces surface NNS cord-255011-7oqfod62 83 18 . . . cord-255011-7oqfod62 84 1 It -PRON- PRP cord-255011-7oqfod62 84 2 is be VBZ cord-255011-7oqfod62 84 3 not not RB cord-255011-7oqfod62 84 4 possible possible JJ cord-255011-7oqfod62 84 5 to to TO cord-255011-7oqfod62 84 6 discuss discuss VB cord-255011-7oqfod62 84 7 the the DT cord-255011-7oqfod62 84 8 pathogenesis pathogenesis NN cord-255011-7oqfod62 84 9 and and CC cord-255011-7oqfod62 84 10 clinical clinical JJ cord-255011-7oqfod62 84 11 signs sign NNS cord-255011-7oqfod62 84 12 associated associate VBN cord-255011-7oqfod62 84 13 with with IN cord-255011-7oqfod62 84 14 CRCoV crcov NN cord-255011-7oqfod62 84 15 without without IN cord-255011-7oqfod62 84 16 considering consider VBG cord-255011-7oqfod62 84 17 the the DT cord-255011-7oqfod62 84 18 CIRD CIRD NNP cord-255011-7oqfod62 84 19 complex complex JJ cord-255011-7oqfod62 84 20 as as IN cord-255011-7oqfod62 84 21 a a DT cord-255011-7oqfod62 84 22 whole whole NN cord-255011-7oqfod62 84 23 . . . cord-255011-7oqfod62 85 1 CRCoV CRCoV NNP cord-255011-7oqfod62 85 2 has have VBZ cord-255011-7oqfod62 85 3 been be VBN cord-255011-7oqfod62 85 4 detected detect VBN cord-255011-7oqfod62 85 5 in in IN cord-255011-7oqfod62 85 6 several several JJ cord-255011-7oqfod62 85 7 studies study NNS cord-255011-7oqfod62 85 8 in in IN cord-255011-7oqfod62 85 9 dogs dog NNS cord-255011-7oqfod62 85 10 with with IN cord-255011-7oqfod62 85 11 respiratory respiratory JJ cord-255011-7oqfod62 85 12 disease disease NN cord-255011-7oqfod62 85 13 . . . cord-255011-7oqfod62 86 1 In in IN cord-255011-7oqfod62 86 2 most most JJS cord-255011-7oqfod62 86 3 of of IN cord-255011-7oqfod62 86 4 these these DT cord-255011-7oqfod62 86 5 cases case NNS cord-255011-7oqfod62 86 6 , , , cord-255011-7oqfod62 86 7 however however RB cord-255011-7oqfod62 86 8 , , , cord-255011-7oqfod62 86 9 other other JJ cord-255011-7oqfod62 86 10 respiratory respiratory JJ cord-255011-7oqfod62 86 11 pathogens pathogen NNS cord-255011-7oqfod62 86 12 were be VBD cord-255011-7oqfod62 86 13 also also RB cord-255011-7oqfod62 86 14 present present JJ cord-255011-7oqfod62 86 15 . . . cord-255011-7oqfod62 87 1 In in IN cord-255011-7oqfod62 87 2 two two CD cord-255011-7oqfod62 87 3 detailed detailed JJ cord-255011-7oqfod62 87 4 studies study NNS cord-255011-7oqfod62 87 5 into into IN cord-255011-7oqfod62 87 6 the the DT cord-255011-7oqfod62 87 7 causes cause NNS cord-255011-7oqfod62 87 8 of of IN cord-255011-7oqfod62 87 9 CIRD CIRD NNP cord-255011-7oqfod62 87 10 in in IN cord-255011-7oqfod62 87 11 which which WDT cord-255011-7oqfod62 87 12 evidence evidence NN cord-255011-7oqfod62 87 13 of of IN cord-255011-7oqfod62 87 14 CRCoV CRCoV NNP cord-255011-7oqfod62 87 15 was be VBD cord-255011-7oqfod62 87 16 reported report VBN cord-255011-7oqfod62 87 17 , , , cord-255011-7oqfod62 87 18 the the DT cord-255011-7oqfod62 87 19 dogs dog NNS cord-255011-7oqfod62 87 20 presented present VBN cord-255011-7oqfod62 87 21 with with IN cord-255011-7oqfod62 87 22 the the DT cord-255011-7oqfod62 87 23 typical typical JJ cord-255011-7oqfod62 87 24 signs sign NNS cord-255011-7oqfod62 87 25 of of IN cord-255011-7oqfod62 87 26 a a DT cord-255011-7oqfod62 87 27 dry dry JJ cord-255011-7oqfod62 87 28 cough cough NN cord-255011-7oqfod62 87 29 and and CC cord-255011-7oqfod62 87 30 nasal nasal NN cord-255011-7oqfod62 87 31 discharge discharge NN cord-255011-7oqfod62 87 32 [ [ -LRB- cord-255011-7oqfod62 87 33 21 21 CD cord-255011-7oqfod62 87 34 , , , cord-255011-7oqfod62 87 35 28 28 CD cord-255011-7oqfod62 87 36 ] ] -RRB- cord-255011-7oqfod62 87 37 . . . cord-255011-7oqfod62 88 1 Concurrent concurrent JJ cord-255011-7oqfod62 88 2 infections infection NNS cord-255011-7oqfod62 88 3 were be VBD cord-255011-7oqfod62 88 4 most most RBS cord-255011-7oqfod62 88 5 frequently frequently RB cord-255011-7oqfod62 88 6 caused cause VBN cord-255011-7oqfod62 88 7 by by IN cord-255011-7oqfod62 88 8 CPIV CPIV NNP cord-255011-7oqfod62 88 9 and and CC cord-255011-7oqfod62 88 10 B B NNP cord-255011-7oqfod62 88 11 bronchiseptica bronchiseptica NNP cord-255011-7oqfod62 88 12 . . . cord-255011-7oqfod62 89 1 CRCoV CRCoV NNP cord-255011-7oqfod62 89 2 has have VBZ cord-255011-7oqfod62 89 3 also also RB cord-255011-7oqfod62 89 4 been be VBN cord-255011-7oqfod62 89 5 detected detect VBN cord-255011-7oqfod62 89 6 in in IN cord-255011-7oqfod62 89 7 dogs dog NNS cord-255011-7oqfod62 89 8 that that WDT cord-255011-7oqfod62 89 9 have have VBP cord-255011-7oqfod62 89 10 nonrespiratory nonrespiratory NN cord-255011-7oqfod62 89 11 disease disease NN cord-255011-7oqfod62 89 12 . . . cord-255011-7oqfod62 90 1 It -PRON- PRP cord-255011-7oqfod62 90 2 was be VBD cord-255011-7oqfod62 90 3 detected detect VBN cord-255011-7oqfod62 90 4 in in IN cord-255011-7oqfod62 90 5 the the DT cord-255011-7oqfod62 90 6 lung lung NN cord-255011-7oqfod62 90 7 , , , cord-255011-7oqfod62 90 8 spleen spleen NNS cord-255011-7oqfod62 90 9 , , , cord-255011-7oqfod62 90 10 mesenteric mesenteric JJ cord-255011-7oqfod62 90 11 lymph lymph NN cord-255011-7oqfod62 90 12 nodes node NNS cord-255011-7oqfod62 90 13 , , , cord-255011-7oqfod62 90 14 and and CC cord-255011-7oqfod62 90 15 intestines intestine NNS cord-255011-7oqfod62 90 16 of of IN cord-255011-7oqfod62 90 17 a a DT cord-255011-7oqfod62 90 18 dog dog NN cord-255011-7oqfod62 90 19 that that WDT cord-255011-7oqfod62 90 20 had have VBD cord-255011-7oqfod62 90 21 died die VBN cord-255011-7oqfod62 90 22 from from IN cord-255011-7oqfod62 90 23 hemorrhagic hemorrhagic JJ cord-255011-7oqfod62 90 24 gastroenteritis gastroenteritis NN cord-255011-7oqfod62 90 25 [ [ -LRB- cord-255011-7oqfod62 90 26 26 26 CD cord-255011-7oqfod62 90 27 ] ] -RRB- cord-255011-7oqfod62 90 28 . . . cord-255011-7oqfod62 91 1 The the DT cord-255011-7oqfod62 91 2 dog dog NN cord-255011-7oqfod62 91 3 also also RB cord-255011-7oqfod62 91 4 tested test VBD cord-255011-7oqfod62 91 5 positive positive JJ cord-255011-7oqfod62 91 6 for for IN cord-255011-7oqfod62 91 7 canine canine JJ cord-255011-7oqfod62 91 8 parvovirus parvovirus NN cord-255011-7oqfod62 91 9 type type NN cord-255011-7oqfod62 91 10 2 2 CD cord-255011-7oqfod62 91 11 and and CC cord-255011-7oqfod62 91 12 CCoV. ccov. NN cord-255011-7oqfod62 91 13 Similarly similarly RB cord-255011-7oqfod62 91 14 , , , cord-255011-7oqfod62 91 15 CRCoV CRCoV NNP cord-255011-7oqfod62 91 16 was be VBD cord-255011-7oqfod62 91 17 detected detect VBN cord-255011-7oqfod62 91 18 in in IN cord-255011-7oqfod62 91 19 a a DT cord-255011-7oqfod62 91 20 rectal rectal JJ cord-255011-7oqfod62 91 21 swab swab NN cord-255011-7oqfod62 91 22 from from IN cord-255011-7oqfod62 91 23 a a DT cord-255011-7oqfod62 91 24 dog dog NN cord-255011-7oqfod62 91 25 with with IN cord-255011-7oqfod62 91 26 vomiting vomiting NN cord-255011-7oqfod62 91 27 and and CC cord-255011-7oqfod62 91 28 diarrhea diarrhea NN cord-255011-7oqfod62 91 29 , , , cord-255011-7oqfod62 91 30 which which WDT cord-255011-7oqfod62 91 31 was be VBD cord-255011-7oqfod62 91 32 also also RB cord-255011-7oqfod62 91 33 positive positive JJ cord-255011-7oqfod62 91 34 for for IN cord-255011-7oqfod62 91 35 CCoV CCoV NNP cord-255011-7oqfod62 91 36 and and CC cord-255011-7oqfod62 91 37 CPIV CPIV NNP cord-255011-7oqfod62 91 38 [ [ -LRB- cord-255011-7oqfod62 91 39 22 22 CD cord-255011-7oqfod62 91 40 ] ] -RRB- cord-255011-7oqfod62 91 41 . . . cord-255011-7oqfod62 92 1 In in IN cord-255011-7oqfod62 92 2 both both DT cord-255011-7oqfod62 92 3 cases case NNS cord-255011-7oqfod62 92 4 , , , cord-255011-7oqfod62 92 5 the the DT cord-255011-7oqfod62 92 6 concurrent concurrent JJ cord-255011-7oqfod62 92 7 infections infection NNS cord-255011-7oqfod62 92 8 with with IN cord-255011-7oqfod62 92 9 canine canine JJ cord-255011-7oqfod62 92 10 parvovirus parvovirus NN cord-255011-7oqfod62 92 11 or or CC cord-255011-7oqfod62 92 12 CCoV ccov ADD cord-255011-7oqfod62 92 13 are be VBP cord-255011-7oqfod62 92 14 likely likely JJ cord-255011-7oqfod62 92 15 to to TO cord-255011-7oqfod62 92 16 have have VB cord-255011-7oqfod62 92 17 been be VBN cord-255011-7oqfod62 92 18 the the DT cord-255011-7oqfod62 92 19 cause cause NN cord-255011-7oqfod62 92 20 of of IN cord-255011-7oqfod62 92 21 the the DT cord-255011-7oqfod62 92 22 clinical clinical JJ cord-255011-7oqfod62 92 23 signs sign NNS cord-255011-7oqfod62 92 24 . . . cord-255011-7oqfod62 93 1 Studies study NNS cord-255011-7oqfod62 93 2 of of IN cord-255011-7oqfod62 93 3 the the DT cord-255011-7oqfod62 93 4 tissue tissue NN cord-255011-7oqfod62 93 5 distribution distribution NN cord-255011-7oqfod62 93 6 of of IN cord-255011-7oqfod62 93 7 CRCoV crcov NN cord-255011-7oqfod62 93 8 in in IN cord-255011-7oqfod62 93 9 10 10 CD cord-255011-7oqfod62 93 10 naturally naturally RB cord-255011-7oqfod62 93 11 infected infect VBN cord-255011-7oqfod62 93 12 dogs dog NNS cord-255011-7oqfod62 93 13 showed show VBD cord-255011-7oqfod62 93 14 that that IN cord-255011-7oqfod62 93 15 CRCoV crcov NN cord-255011-7oqfod62 93 16 was be VBD cord-255011-7oqfod62 93 17 most most RBS cord-255011-7oqfod62 93 18 frequently frequently RB cord-255011-7oqfod62 93 19 detected detect VBN cord-255011-7oqfod62 93 20 in in IN cord-255011-7oqfod62 93 21 the the DT cord-255011-7oqfod62 93 22 nasal nasal NN cord-255011-7oqfod62 93 23 cavity cavity NN cord-255011-7oqfod62 93 24 , , , cord-255011-7oqfod62 93 25 nasal nasal JJ cord-255011-7oqfod62 93 26 tonsil tonsil NN cord-255011-7oqfod62 93 27 , , , cord-255011-7oqfod62 93 28 and and CC cord-255011-7oqfod62 93 29 trachea trachea NN cord-255011-7oqfod62 93 30 and and CC cord-255011-7oqfod62 93 31 less less RBR cord-255011-7oqfod62 93 32 frequently frequently RB cord-255011-7oqfod62 93 33 in in IN cord-255011-7oqfod62 93 34 the the DT cord-255011-7oqfod62 93 35 lung lung NN cord-255011-7oqfod62 93 36 , , , cord-255011-7oqfod62 93 37 bronchial bronchial JJ cord-255011-7oqfod62 93 38 lymph lymph NN cord-255011-7oqfod62 93 39 nodes node NNS cord-255011-7oqfod62 93 40 , , , cord-255011-7oqfod62 93 41 and and CC cord-255011-7oqfod62 93 42 palatine palatine NNP cord-255011-7oqfod62 93 43 tonsil tonsil NNP cord-255011-7oqfod62 93 44 . . . cord-255011-7oqfod62 94 1 It -PRON- PRP cord-255011-7oqfod62 94 2 was be VBD cord-255011-7oqfod62 94 3 also also RB cord-255011-7oqfod62 94 4 detected detect VBN cord-255011-7oqfod62 94 5 in in IN cord-255011-7oqfod62 94 6 samples sample NNS cord-255011-7oqfod62 94 7 from from IN cord-255011-7oqfod62 94 8 the the DT cord-255011-7oqfod62 94 9 spleen spleen NN cord-255011-7oqfod62 94 10 , , , cord-255011-7oqfod62 94 11 mesenteric mesenteric JJ cord-255011-7oqfod62 94 12 lymph lymph NN cord-255011-7oqfod62 94 13 nodes node NNS cord-255011-7oqfod62 94 14 , , , cord-255011-7oqfod62 94 15 and and CC cord-255011-7oqfod62 94 16 colon colon NN cord-255011-7oqfod62 94 17 but but CC cord-255011-7oqfod62 94 18 not not RB cord-255011-7oqfod62 94 19 in in IN cord-255011-7oqfod62 94 20 the the DT cord-255011-7oqfod62 94 21 enteric enteric JJ cord-255011-7oqfod62 94 22 content content NN cord-255011-7oqfod62 95 1 ( ( -LRB- cord-255011-7oqfod62 95 2 K. K. NNP cord-255011-7oqfod62 95 3 Erles Erles NNP cord-255011-7oqfod62 95 4 , , , cord-255011-7oqfod62 95 5 unpublished unpublished JJ cord-255011-7oqfod62 95 6 data datum NNS cord-255011-7oqfod62 95 7 , , , cord-255011-7oqfod62 95 8 2004 2004 CD cord-255011-7oqfod62 95 9 ) ) -RRB- cord-255011-7oqfod62 95 10 . . . cord-255011-7oqfod62 96 1 The the DT cord-255011-7oqfod62 96 2 tissue tissue NN cord-255011-7oqfod62 96 3 tropism tropism NN cord-255011-7oqfod62 96 4 of of IN cord-255011-7oqfod62 96 5 CRCoV crcov NN cord-255011-7oqfod62 96 6 therefore therefore RB cord-255011-7oqfod62 96 7 seems seem VBZ cord-255011-7oqfod62 96 8 not not RB cord-255011-7oqfod62 96 9 to to TO cord-255011-7oqfod62 96 10 be be VB cord-255011-7oqfod62 96 11 exclusively exclusively RB cord-255011-7oqfod62 96 12 respiratory respiratory JJ cord-255011-7oqfod62 96 13 , , , cord-255011-7oqfod62 96 14 and and CC cord-255011-7oqfod62 96 15 fecal fecal JJ cord-255011-7oqfod62 96 16 - - HYPH cord-255011-7oqfod62 96 17 oral oral JJ cord-255011-7oqfod62 96 18 transmission transmission NN cord-255011-7oqfod62 96 19 of of IN cord-255011-7oqfod62 96 20 CRCoV crcov NN cord-255011-7oqfod62 96 21 may may MD cord-255011-7oqfod62 96 22 be be VB cord-255011-7oqfod62 96 23 possible possible JJ cord-255011-7oqfod62 96 24 . . . cord-255011-7oqfod62 97 1 CRCoV CRCoV NNP cord-255011-7oqfod62 97 2 may may MD cord-255011-7oqfod62 97 3 show show VB cord-255011-7oqfod62 97 4 a a DT cord-255011-7oqfod62 97 5 dual dual JJ cord-255011-7oqfod62 97 6 tropism tropism NN cord-255011-7oqfod62 97 7 , , , cord-255011-7oqfod62 97 8 similar similar JJ cord-255011-7oqfod62 97 9 to to IN cord-255011-7oqfod62 97 10 BCoV BCoV NNP cord-255011-7oqfod62 97 11 , , , cord-255011-7oqfod62 97 12 but but CC cord-255011-7oqfod62 97 13 the the DT cord-255011-7oqfod62 97 14 ability ability NN cord-255011-7oqfod62 97 15 of of IN cord-255011-7oqfod62 97 16 the the DT cord-255011-7oqfod62 97 17 virus virus NN cord-255011-7oqfod62 97 18 to to TO cord-255011-7oqfod62 97 19 replicate replicate VB cord-255011-7oqfod62 97 20 in in IN cord-255011-7oqfod62 97 21 the the DT cord-255011-7oqfod62 97 22 epithelium epithelium NN cord-255011-7oqfod62 97 23 of of IN cord-255011-7oqfod62 97 24 the the DT cord-255011-7oqfod62 97 25 gastrointestinal gastrointestinal JJ cord-255011-7oqfod62 97 26 tract tract NN cord-255011-7oqfod62 97 27 and and CC cord-255011-7oqfod62 97 28 the the DT cord-255011-7oqfod62 97 29 clinical clinical JJ cord-255011-7oqfod62 97 30 consequences consequence NNS cord-255011-7oqfod62 97 31 need need VBP cord-255011-7oqfod62 97 32 further further JJ cord-255011-7oqfod62 97 33 investigation investigation NN cord-255011-7oqfod62 97 34 . . . cord-255011-7oqfod62 98 1 Experimental experimental JJ cord-255011-7oqfod62 98 2 studies study NNS cord-255011-7oqfod62 98 3 using use VBG cord-255011-7oqfod62 98 4 CRCoV crcov NN cord-255011-7oqfod62 98 5 have have VBP cord-255011-7oqfod62 98 6 not not RB cord-255011-7oqfod62 98 7 been be VBN cord-255011-7oqfod62 98 8 reported report VBN cord-255011-7oqfod62 98 9 to to IN cord-255011-7oqfod62 98 10 date date NN cord-255011-7oqfod62 98 11 . . . cord-255011-7oqfod62 99 1 A a DT cord-255011-7oqfod62 99 2 study study NN cord-255011-7oqfod62 99 3 using use VBG cord-255011-7oqfod62 99 4 BCoV BCoV NNP cord-255011-7oqfod62 99 5 showed show VBD cord-255011-7oqfod62 99 6 that that IN cord-255011-7oqfod62 99 7 dogs dog NNS cord-255011-7oqfod62 99 8 became become VBD cord-255011-7oqfod62 99 9 infected infected JJ cord-255011-7oqfod62 99 10 and and CC cord-255011-7oqfod62 99 11 transmitted transmit VBN cord-255011-7oqfod62 99 12 the the DT cord-255011-7oqfod62 99 13 virus virus NN cord-255011-7oqfod62 99 14 to to TO cord-255011-7oqfod62 99 15 contact contact VB cord-255011-7oqfod62 99 16 dogs dog NNS cord-255011-7oqfod62 99 17 . . . cord-255011-7oqfod62 100 1 BCoV BCoV NNP cord-255011-7oqfod62 100 2 was be VBD cord-255011-7oqfod62 100 3 detected detect VBN cord-255011-7oqfod62 100 4 in in IN cord-255011-7oqfod62 100 5 rectal rectal JJ cord-255011-7oqfod62 100 6 and and CC cord-255011-7oqfod62 100 7 oral oral JJ cord-255011-7oqfod62 100 8 swabs swab NNS cord-255011-7oqfod62 100 9 , , , cord-255011-7oqfod62 100 10 and and CC cord-255011-7oqfod62 100 11 the the DT cord-255011-7oqfod62 100 12 dogs dog NNS cord-255011-7oqfod62 100 13 developed develop VBD cord-255011-7oqfod62 100 14 neutralizing neutralize VBG cord-255011-7oqfod62 100 15 antibodies antibody NNS cord-255011-7oqfod62 100 16 to to IN cord-255011-7oqfod62 100 17 the the DT cord-255011-7oqfod62 100 18 virus virus NN cord-255011-7oqfod62 100 19 [ [ -LRB- cord-255011-7oqfod62 100 20 29 29 CD cord-255011-7oqfod62 100 21 ] ] -RRB- cord-255011-7oqfod62 100 22 . . . cord-255011-7oqfod62 101 1 The the DT cord-255011-7oqfod62 101 2 dogs dog NNS cord-255011-7oqfod62 101 3 did do VBD cord-255011-7oqfod62 101 4 not not RB cord-255011-7oqfod62 101 5 develop develop VB cord-255011-7oqfod62 101 6 fever fever NN cord-255011-7oqfod62 101 7 or or CC cord-255011-7oqfod62 101 8 any any DT cord-255011-7oqfod62 101 9 clinical clinical JJ cord-255011-7oqfod62 101 10 signs sign NNS cord-255011-7oqfod62 101 11 of of IN cord-255011-7oqfod62 101 12 respiratory respiratory JJ cord-255011-7oqfod62 101 13 or or CC cord-255011-7oqfod62 101 14 gastrointestinal gastrointestinal JJ cord-255011-7oqfod62 101 15 disease disease NN cord-255011-7oqfod62 101 16 . . . cord-255011-7oqfod62 102 1 Despite despite IN cord-255011-7oqfod62 102 2 their -PRON- PRP$ cord-255011-7oqfod62 102 3 high high JJ cord-255011-7oqfod62 102 4 similarity similarity NN cord-255011-7oqfod62 102 5 , , , cord-255011-7oqfod62 102 6 BCoV BCoV NNP cord-255011-7oqfod62 102 7 may may MD cord-255011-7oqfod62 102 8 be be VB cord-255011-7oqfod62 102 9 less less RBR cord-255011-7oqfod62 102 10 pathogenic pathogenic JJ cord-255011-7oqfod62 102 11 in in IN cord-255011-7oqfod62 102 12 dogs dog NNS cord-255011-7oqfod62 102 13 compared compare VBN cord-255011-7oqfod62 102 14 with with IN cord-255011-7oqfod62 102 15 CRCoV. crcov. NN cord-255011-7oqfod62 103 1 Furthermore furthermore RB cord-255011-7oqfod62 103 2 , , , cord-255011-7oqfod62 103 3 the the DT cord-255011-7oqfod62 103 4 etiology etiology NN cord-255011-7oqfod62 103 5 of of IN cord-255011-7oqfod62 103 6 CIRD CIRD NNP cord-255011-7oqfod62 103 7 has have VBZ cord-255011-7oqfod62 103 8 been be VBN cord-255011-7oqfod62 103 9 shown show VBN cord-255011-7oqfod62 103 10 to to TO cord-255011-7oqfod62 103 11 involve involve VB cord-255011-7oqfod62 103 12 multiple multiple JJ cord-255011-7oqfod62 103 13 pathogens pathogen NNS cord-255011-7oqfod62 103 14 . . . cord-255011-7oqfod62 104 1 Viral viral JJ cord-255011-7oqfod62 104 2 infections infection NNS cord-255011-7oqfod62 104 3 can can MD cord-255011-7oqfod62 104 4 aid aid VB cord-255011-7oqfod62 104 5 the the DT cord-255011-7oqfod62 104 6 entry entry NN cord-255011-7oqfod62 104 7 of of IN cord-255011-7oqfod62 104 8 other other JJ cord-255011-7oqfod62 104 9 pathogens pathogen NNS cord-255011-7oqfod62 104 10 by by IN cord-255011-7oqfod62 104 11 facilitating facilitate VBG cord-255011-7oqfod62 104 12 their -PRON- PRP$ cord-255011-7oqfod62 104 13 attachment attachment NN cord-255011-7oqfod62 104 14 or or CC cord-255011-7oqfod62 104 15 by by IN cord-255011-7oqfod62 104 16 inhibition inhibition NN cord-255011-7oqfod62 104 17 of of IN cord-255011-7oqfod62 104 18 the the DT cord-255011-7oqfod62 104 19 mucociliary mucociliary JJ cord-255011-7oqfod62 104 20 clearance clearance NN cord-255011-7oqfod62 104 21 . . . cord-255011-7oqfod62 105 1 Many many JJ cord-255011-7oqfod62 105 2 pathogens pathogen NNS cord-255011-7oqfod62 105 3 known know VBN cord-255011-7oqfod62 105 4 to to TO cord-255011-7oqfod62 105 5 be be VB cord-255011-7oqfod62 105 6 involved involve VBN cord-255011-7oqfod62 105 7 in in IN cord-255011-7oqfod62 105 8 the the DT cord-255011-7oqfod62 105 9 CIRD CIRD NNP cord-255011-7oqfod62 105 10 complex complex NN cord-255011-7oqfod62 105 11 have have VBP cord-255011-7oqfod62 105 12 also also RB cord-255011-7oqfod62 105 13 been be VBN cord-255011-7oqfod62 105 14 found find VBN cord-255011-7oqfod62 105 15 in in IN cord-255011-7oqfod62 105 16 dogs dog NNS cord-255011-7oqfod62 105 17 without without IN cord-255011-7oqfod62 105 18 clinical clinical JJ cord-255011-7oqfod62 105 19 signs sign NNS cord-255011-7oqfod62 105 20 , , , cord-255011-7oqfod62 105 21 including include VBG cord-255011-7oqfod62 105 22 CPIV CPIV NNP cord-255011-7oqfod62 105 23 and and CC cord-255011-7oqfod62 105 24 B B NNP cord-255011-7oqfod62 105 25 bronchiseptica bronchiseptica NNP cord-255011-7oqfod62 105 26 [ [ -LRB- cord-255011-7oqfod62 105 27 28 28 CD cord-255011-7oqfod62 105 28 , , , cord-255011-7oqfod62 105 29 30 30 CD cord-255011-7oqfod62 105 30 ] ] -RRB- cord-255011-7oqfod62 105 31 . . . cord-255011-7oqfod62 106 1 When when WRB cord-255011-7oqfod62 106 2 assessing assess VBG cord-255011-7oqfod62 106 3 the the DT cord-255011-7oqfod62 106 4 pathogenesis pathogenesis NN cord-255011-7oqfod62 106 5 of of IN cord-255011-7oqfod62 106 6 complex complex JJ cord-255011-7oqfod62 106 7 diseases disease NNS cord-255011-7oqfod62 106 8 , , , cord-255011-7oqfod62 106 9 it -PRON- PRP cord-255011-7oqfod62 106 10 is be VBZ cord-255011-7oqfod62 106 11 important important JJ cord-255011-7oqfod62 106 12 to to TO cord-255011-7oqfod62 106 13 consider consider VB cord-255011-7oqfod62 106 14 the the DT cord-255011-7oqfod62 106 15 possible possible JJ cord-255011-7oqfod62 106 16 interaction interaction NN cord-255011-7oqfod62 106 17 of of IN cord-255011-7oqfod62 106 18 pathogens pathogen NNS cord-255011-7oqfod62 106 19 during during IN cord-255011-7oqfod62 106 20 coinfections coinfection NNS cord-255011-7oqfod62 106 21 and and CC cord-255011-7oqfod62 106 22 contributing contribute VBG cord-255011-7oqfod62 106 23 factors factor NNS cord-255011-7oqfod62 106 24 , , , cord-255011-7oqfod62 106 25 such such JJ cord-255011-7oqfod62 106 26 as as IN cord-255011-7oqfod62 106 27 stress stress NN cord-255011-7oqfod62 106 28 . . . cord-255011-7oqfod62 107 1 Because because IN cord-255011-7oqfod62 107 2 of of IN cord-255011-7oqfod62 107 3 the the DT cord-255011-7oqfod62 107 4 involvement involvement NN cord-255011-7oqfod62 107 5 of of IN cord-255011-7oqfod62 107 6 multiple multiple JJ cord-255011-7oqfod62 107 7 pathogens pathogen NNS cord-255011-7oqfod62 107 8 in in IN cord-255011-7oqfod62 107 9 the the DT cord-255011-7oqfod62 107 10 etiology etiology NN cord-255011-7oqfod62 107 11 of of IN cord-255011-7oqfod62 107 12 CIRD CIRD NNP cord-255011-7oqfod62 107 13 , , , cord-255011-7oqfod62 107 14 it -PRON- PRP cord-255011-7oqfod62 107 15 is be VBZ cord-255011-7oqfod62 107 16 not not RB cord-255011-7oqfod62 107 17 possible possible JJ cord-255011-7oqfod62 107 18 to to TO cord-255011-7oqfod62 107 19 diagnose diagnose VB cord-255011-7oqfod62 107 20 CRCoV crcov NN cord-255011-7oqfod62 107 21 solely solely RB cord-255011-7oqfod62 107 22 by by IN cord-255011-7oqfod62 107 23 clinical clinical JJ cord-255011-7oqfod62 107 24 signs sign NNS cord-255011-7oqfod62 107 25 . . . cord-255011-7oqfod62 108 1 The the DT cord-255011-7oqfod62 108 2 most most RBS cord-255011-7oqfod62 108 3 suitable suitable JJ cord-255011-7oqfod62 108 4 test test NN cord-255011-7oqfod62 108 5 to to TO cord-255011-7oqfod62 108 6 diagnose diagnose VB cord-255011-7oqfod62 108 7 CRCoV crcov NN cord-255011-7oqfod62 108 8 in in IN cord-255011-7oqfod62 108 9 respiratory respiratory JJ cord-255011-7oqfod62 108 10 samples sample NNS cord-255011-7oqfod62 108 11 is be VBZ cord-255011-7oqfod62 108 12 nested nest VBN cord-255011-7oqfod62 108 13 RT RT NNP cord-255011-7oqfod62 108 14 - - HYPH cord-255011-7oqfod62 108 15 PCR PCR NNP cord-255011-7oqfod62 108 16 based base VBN cord-255011-7oqfod62 108 17 on on IN cord-255011-7oqfod62 108 18 the the DT cord-255011-7oqfod62 108 19 spike spike NN cord-255011-7oqfod62 108 20 glycoprotein glycoprotein NN cord-255011-7oqfod62 108 21 gene gene NN cord-255011-7oqfod62 108 22 [ [ -LRB- cord-255011-7oqfod62 108 23 9 9 CD cord-255011-7oqfod62 108 24 ] ] -RRB- cord-255011-7oqfod62 108 25 or or CC cord-255011-7oqfod62 108 26 the the DT cord-255011-7oqfod62 108 27 hemagglutinin hemagglutinin NN cord-255011-7oqfod62 108 28 - - HYPH cord-255011-7oqfod62 108 29 esterase esterase NN cord-255011-7oqfod62 108 30 gene gene NN cord-255011-7oqfod62 108 31 [ [ -LRB- cord-255011-7oqfod62 108 32 22 22 CD cord-255011-7oqfod62 108 33 ] ] -RRB- cord-255011-7oqfod62 108 34 . . . cord-255011-7oqfod62 109 1 This this DT cord-255011-7oqfod62 109 2 test test NN cord-255011-7oqfod62 109 3 has have VBZ cord-255011-7oqfod62 109 4 a a DT cord-255011-7oqfod62 109 5 high high JJ cord-255011-7oqfod62 109 6 sensitivity sensitivity NN cord-255011-7oqfod62 109 7 , , , cord-255011-7oqfod62 109 8 which which WDT cord-255011-7oqfod62 109 9 is be VBZ cord-255011-7oqfod62 109 10 particularly particularly RB cord-255011-7oqfod62 109 11 useful useful JJ cord-255011-7oqfod62 109 12 when when WRB cord-255011-7oqfod62 109 13 analyzing analyze VBG cord-255011-7oqfod62 109 14 samples sample NNS cord-255011-7oqfod62 109 15 with with IN cord-255011-7oqfod62 109 16 a a DT cord-255011-7oqfod62 109 17 potentially potentially RB cord-255011-7oqfod62 109 18 low low JJ cord-255011-7oqfod62 109 19 number number NN cord-255011-7oqfod62 109 20 of of IN cord-255011-7oqfod62 109 21 cells cell NNS cord-255011-7oqfod62 109 22 , , , cord-255011-7oqfod62 109 23 such such JJ cord-255011-7oqfod62 109 24 as as IN cord-255011-7oqfod62 109 25 oropharyngeal oropharyngeal JJ cord-255011-7oqfod62 109 26 or or CC cord-255011-7oqfod62 109 27 nasal nasal NN cord-255011-7oqfod62 109 28 swabs swab NNS cord-255011-7oqfod62 109 29 . . . cord-255011-7oqfod62 110 1 Both both DT cord-255011-7oqfod62 110 2 PCR PCR NNP cord-255011-7oqfod62 110 3 methods method NNS cord-255011-7oqfod62 110 4 are be VBP cord-255011-7oqfod62 110 5 specific specific JJ cord-255011-7oqfod62 110 6 for for IN cord-255011-7oqfod62 110 7 CRCoV crcov NN cord-255011-7oqfod62 110 8 and and CC cord-255011-7oqfod62 110 9 do do VBP cord-255011-7oqfod62 110 10 not not RB cord-255011-7oqfod62 110 11 detect detect VB cord-255011-7oqfod62 110 12 enteric enteric JJ cord-255011-7oqfod62 110 13 CCoV. ccov. NN cord-255011-7oqfod62 110 14 Because because IN cord-255011-7oqfod62 110 15 the the DT cord-255011-7oqfod62 110 16 virus virus NN cord-255011-7oqfod62 110 17 was be VBD cord-255011-7oqfod62 110 18 found find VBN cord-255011-7oqfod62 110 19 most most RBS cord-255011-7oqfod62 110 20 frequently frequently RB cord-255011-7oqfod62 110 21 in in IN cord-255011-7oqfod62 110 22 the the DT cord-255011-7oqfod62 110 23 nasal nasal NN cord-255011-7oqfod62 110 24 cavity cavity NN cord-255011-7oqfod62 110 25 , , , cord-255011-7oqfod62 110 26 nasal nasal NN cord-255011-7oqfod62 110 27 swabs swab NNS cord-255011-7oqfod62 110 28 are be VBP cord-255011-7oqfod62 110 29 suitable suitable JJ cord-255011-7oqfod62 110 30 diagnostic diagnostic JJ cord-255011-7oqfod62 110 31 samples sample NNS cord-255011-7oqfod62 110 32 . . . cord-255011-7oqfod62 111 1 CRCoV CRCoV NNP cord-255011-7oqfod62 111 2 has have VBZ cord-255011-7oqfod62 111 3 also also RB cord-255011-7oqfod62 111 4 been be VBN cord-255011-7oqfod62 111 5 detected detect VBN cord-255011-7oqfod62 111 6 in in IN cord-255011-7oqfod62 111 7 oral oral JJ cord-255011-7oqfod62 111 8 swabs swab NNS cord-255011-7oqfod62 111 9 , , , cord-255011-7oqfod62 111 10 and and CC cord-255011-7oqfod62 111 11 , , , cord-255011-7oqfod62 111 12 furthermore furthermore RB cord-255011-7oqfod62 111 13 , , , cord-255011-7oqfod62 111 14 nasal nasal NN cord-255011-7oqfod62 111 15 or or CC cord-255011-7oqfod62 111 16 tracheal tracheal JJ cord-255011-7oqfod62 111 17 washes wash NNS cord-255011-7oqfod62 111 18 are be VBP cord-255011-7oqfod62 111 19 likely likely JJ cord-255011-7oqfod62 111 20 to to TO cord-255011-7oqfod62 111 21 yield yield VB cord-255011-7oqfod62 111 22 CRCoV crcov NN cord-255011-7oqfod62 111 23 during during IN cord-255011-7oqfod62 111 24 an an DT cord-255011-7oqfod62 111 25 active active JJ cord-255011-7oqfod62 111 26 infection infection NN cord-255011-7oqfod62 111 27 . . . cord-255011-7oqfod62 112 1 If if IN cord-255011-7oqfod62 112 2 postmortem postmortem JJ cord-255011-7oqfod62 112 3 samples sample NNS cord-255011-7oqfod62 112 4 are be VBP cord-255011-7oqfod62 112 5 available available JJ cord-255011-7oqfod62 112 6 , , , cord-255011-7oqfod62 112 7 nasal nasal JJ cord-255011-7oqfod62 112 8 cavity cavity NN cord-255011-7oqfod62 112 9 , , , cord-255011-7oqfod62 112 10 nasal nasal NN cord-255011-7oqfod62 112 11 tonsil tonsil NN cord-255011-7oqfod62 112 12 , , , cord-255011-7oqfod62 112 13 trachea trachea NN cord-255011-7oqfod62 112 14 , , , cord-255011-7oqfod62 112 15 and and CC cord-255011-7oqfod62 112 16 lung lung NN cord-255011-7oqfod62 112 17 samples sample NNS cord-255011-7oqfod62 112 18 should should MD cord-255011-7oqfod62 112 19 be be VB cord-255011-7oqfod62 112 20 collected collect VBN cord-255011-7oqfod62 112 21 for for IN cord-255011-7oqfod62 112 22 analysis analysis NN cord-255011-7oqfod62 112 23 . . . cord-255011-7oqfod62 113 1 Isolation isolation NN cord-255011-7oqfod62 113 2 of of IN cord-255011-7oqfod62 113 3 CRCoV crcov NN cord-255011-7oqfod62 113 4 in in IN cord-255011-7oqfod62 113 5 cell cell NN cord-255011-7oqfod62 113 6 culture culture NN cord-255011-7oqfod62 113 7 has have VBZ cord-255011-7oqfod62 113 8 been be VBN cord-255011-7oqfod62 113 9 achieved achieve VBN cord-255011-7oqfod62 113 10 ; ; : cord-255011-7oqfod62 113 11 however however RB cord-255011-7oqfod62 113 12 , , , cord-255011-7oqfod62 113 13 it -PRON- PRP cord-255011-7oqfod62 113 14 is be VBZ cord-255011-7oqfod62 113 15 not not RB cord-255011-7oqfod62 113 16 recommended recommend VBN cord-255011-7oqfod62 113 17 to to TO cord-255011-7oqfod62 113 18 use use VB cord-255011-7oqfod62 113 19 virus virus NN cord-255011-7oqfod62 113 20 isolation isolation NN cord-255011-7oqfod62 113 21 alone alone JJ cord-255011-7oqfod62 113 22 to to TO cord-255011-7oqfod62 113 23 diagnose diagnose VB cord-255011-7oqfod62 113 24 CRCoV. crcov. NN cord-255011-7oqfod62 114 1 To to IN cord-255011-7oqfod62 114 2 date date NN cord-255011-7oqfod62 114 3 , , , cord-255011-7oqfod62 114 4 isolation isolation NN cord-255011-7oqfod62 114 5 of of IN cord-255011-7oqfod62 114 6 CRCoV CRCoV NNP cord-255011-7oqfod62 114 7 has have VBZ cord-255011-7oqfod62 114 8 only only RB cord-255011-7oqfod62 114 9 succeeded succeed VBN cord-255011-7oqfod62 114 10 on on IN cord-255011-7oqfod62 114 11 the the DT cord-255011-7oqfod62 114 12 human human JJ cord-255011-7oqfod62 114 13 rectal rectal JJ cord-255011-7oqfod62 114 14 tumor tumor NN cord-255011-7oqfod62 114 15 cell cell NN cord-255011-7oqfod62 114 16 line line NN cord-255011-7oqfod62 114 17 HRT-18 HRT-18 NNP cord-255011-7oqfod62 114 18 and and CC cord-255011-7oqfod62 114 19 its -PRON- PRP$ cord-255011-7oqfod62 114 20 clone clone NN cord-255011-7oqfod62 114 21 HRT-18 HRT-18 NNP cord-255011-7oqfod62 114 22 G G NNP cord-255011-7oqfod62 114 23 [ [ -LRB- cord-255011-7oqfod62 114 24 13 13 CD cord-255011-7oqfod62 114 25 ] ] -RRB- cord-255011-7oqfod62 114 26 . . . cord-255011-7oqfod62 115 1 Even even RB cord-255011-7oqfod62 115 2 on on IN cord-255011-7oqfod62 115 3 HRT-18 HRT-18 NNP cord-255011-7oqfod62 115 4 cells cell NNS cord-255011-7oqfod62 115 5 , , , cord-255011-7oqfod62 115 6 the the DT cord-255011-7oqfod62 115 7 isolation isolation NN cord-255011-7oqfod62 115 8 of of IN cord-255011-7oqfod62 115 9 CRCoV crcov NN cord-255011-7oqfod62 115 10 from from IN cord-255011-7oqfod62 115 11 RT RT NNP cord-255011-7oqfod62 115 12 - - HYPH cord-255011-7oqfod62 115 13 PCR pcr NN cord-255011-7oqfod62 115 14 - - HYPH cord-255011-7oqfod62 115 15 positive positive JJ cord-255011-7oqfod62 115 16 samples sample NNS cord-255011-7oqfod62 115 17 is be VBZ cord-255011-7oqfod62 115 18 often often RB cord-255011-7oqfod62 115 19 unsuccessful unsuccessful JJ cord-255011-7oqfod62 115 20 [ [ -LRB- cord-255011-7oqfod62 115 21 22 22 CD cord-255011-7oqfod62 115 22 , , , cord-255011-7oqfod62 115 23 23 23 CD cord-255011-7oqfod62 115 24 , , , cord-255011-7oqfod62 115 25 26 26 CD cord-255011-7oqfod62 115 26 ] ] -RRB- cord-255011-7oqfod62 115 27 . . . cord-255011-7oqfod62 116 1 The the DT cord-255011-7oqfod62 116 2 only only JJ cord-255011-7oqfod62 116 3 isolate isolate NN cord-255011-7oqfod62 116 4 of of IN cord-255011-7oqfod62 116 5 CRCoV crcov NN cord-255011-7oqfod62 116 6 that that WDT cord-255011-7oqfod62 116 7 has have VBZ cord-255011-7oqfod62 116 8 so so RB cord-255011-7oqfod62 116 9 far far RB cord-255011-7oqfod62 116 10 been be VBN cord-255011-7oqfod62 116 11 studied study VBN cord-255011-7oqfod62 116 12 in in IN cord-255011-7oqfod62 116 13 detail detail NN cord-255011-7oqfod62 116 14 did do VBD cord-255011-7oqfod62 116 15 not not RB cord-255011-7oqfod62 116 16 produce produce VB cord-255011-7oqfod62 116 17 a a DT cord-255011-7oqfod62 116 18 cytopathic cytopathic JJ cord-255011-7oqfod62 116 19 effect effect NN cord-255011-7oqfod62 116 20 on on IN cord-255011-7oqfod62 116 21 HRT-18 HRT-18 NNP cord-255011-7oqfod62 116 22 cells cell NNS cord-255011-7oqfod62 116 23 , , , cord-255011-7oqfod62 116 24 and and CC cord-255011-7oqfod62 116 25 infection infection NN cord-255011-7oqfod62 116 26 had have VBD cord-255011-7oqfod62 116 27 to to TO cord-255011-7oqfod62 116 28 be be VB cord-255011-7oqfod62 116 29 confirmed confirm VBN cord-255011-7oqfod62 116 30 by by IN cord-255011-7oqfod62 116 31 using use VBG cord-255011-7oqfod62 116 32 immunofluorescence immunofluorescence NN cord-255011-7oqfod62 116 33 or or CC cord-255011-7oqfod62 116 34 PCR PCR NNP cord-255011-7oqfod62 116 35 . . . cord-255011-7oqfod62 117 1 Supernatants supernatant NNS cord-255011-7oqfod62 117 2 from from IN cord-255011-7oqfod62 117 3 infected infected JJ cord-255011-7oqfod62 117 4 cell cell NN cord-255011-7oqfod62 117 5 cultures culture NNS cord-255011-7oqfod62 117 6 were be VBD cord-255011-7oqfod62 117 7 found find VBN cord-255011-7oqfod62 117 8 to to TO cord-255011-7oqfod62 117 9 agglutinate agglutinate VB cord-255011-7oqfod62 117 10 chicken chicken NN cord-255011-7oqfod62 117 11 erythrocytes erythrocyte NNS cord-255011-7oqfod62 117 12 at at IN cord-255011-7oqfod62 117 13 4 4 CD cord-255011-7oqfod62 117 14 C C NNP cord-255011-7oqfod62 117 15 [ [ -LRB- cord-255011-7oqfod62 117 16 13 13 CD cord-255011-7oqfod62 117 17 ] ] -RRB- cord-255011-7oqfod62 117 18 . . . cord-255011-7oqfod62 118 1 Hemagglutination hemagglutination NN cord-255011-7oqfod62 118 2 assays assay NNS cord-255011-7oqfod62 118 3 may may MD cord-255011-7oqfod62 118 4 aid aid VB cord-255011-7oqfod62 118 5 in in IN cord-255011-7oqfod62 118 6 detection detection NN cord-255011-7oqfod62 118 7 of of IN cord-255011-7oqfod62 118 8 CRCoV crcov NN cord-255011-7oqfod62 118 9 - - HYPH cord-255011-7oqfod62 118 10 infected infect VBN cord-255011-7oqfod62 118 11 cell cell NN cord-255011-7oqfod62 118 12 cultures culture NNS cord-255011-7oqfod62 118 13 if if IN cord-255011-7oqfod62 118 14 isolation isolation NN cord-255011-7oqfod62 118 15 is be VBZ cord-255011-7oqfod62 118 16 attempted attempt VBN cord-255011-7oqfod62 118 17 . . . cord-255011-7oqfod62 119 1 CRCoV CRCoV NNP cord-255011-7oqfod62 119 2 has have VBZ cord-255011-7oqfod62 119 3 also also RB cord-255011-7oqfod62 119 4 been be VBN cord-255011-7oqfod62 119 5 detected detect VBN cord-255011-7oqfod62 119 6 by by IN cord-255011-7oqfod62 119 7 immunohistochemistry immunohistochemistry NN cord-255011-7oqfod62 119 8 on on IN cord-255011-7oqfod62 119 9 formalin formalin NN cord-255011-7oqfod62 119 10 - - HYPH cord-255011-7oqfod62 119 11 fixed fix VBN cord-255011-7oqfod62 119 12 tissues tissue NNS cord-255011-7oqfod62 119 13 using use VBG cord-255011-7oqfod62 119 14 an an DT cord-255011-7oqfod62 119 15 antibody antibody NN cord-255011-7oqfod62 119 16 directed direct VBN cord-255011-7oqfod62 119 17 against against IN cord-255011-7oqfod62 119 18 BCoV BCoV NNP cord-255011-7oqfod62 119 19 [ [ -LRB- cord-255011-7oqfod62 119 20 12 12 CD cord-255011-7oqfod62 119 21 ] ] -RRB- cord-255011-7oqfod62 119 22 . . . cord-255011-7oqfod62 120 1 The the DT cord-255011-7oqfod62 120 2 sensitivity sensitivity NN cord-255011-7oqfod62 120 3 of of IN cord-255011-7oqfod62 120 4 immunohistochemistry immunohistochemistry NN cord-255011-7oqfod62 120 5 in in IN cord-255011-7oqfod62 120 6 comparison comparison NN cord-255011-7oqfod62 120 7 to to IN cord-255011-7oqfod62 120 8 PCR PCR NNP cord-255011-7oqfod62 120 9 has have VBZ cord-255011-7oqfod62 120 10 not not RB cord-255011-7oqfod62 120 11 been be VBN cord-255011-7oqfod62 120 12 evaluated evaluate VBN cord-255011-7oqfod62 120 13 ; ; : cord-255011-7oqfod62 120 14 however however RB cord-255011-7oqfod62 120 15 , , , cord-255011-7oqfod62 120 16 this this DT cord-255011-7oqfod62 120 17 method method NN cord-255011-7oqfod62 120 18 is be VBZ cord-255011-7oqfod62 120 19 useful useful JJ cord-255011-7oqfod62 120 20 for for IN cord-255011-7oqfod62 120 21 testing test VBG cord-255011-7oqfod62 120 22 archival archival JJ cord-255011-7oqfod62 120 23 respiratory respiratory JJ cord-255011-7oqfod62 120 24 samples sample NNS cord-255011-7oqfod62 120 25 . . . cord-255011-7oqfod62 121 1 Serology serology NN cord-255011-7oqfod62 121 2 is be VBZ cord-255011-7oqfod62 121 3 a a DT cord-255011-7oqfod62 121 4 valuable valuable JJ cord-255011-7oqfod62 121 5 tool tool NN cord-255011-7oqfod62 121 6 for for IN cord-255011-7oqfod62 121 7 the the DT cord-255011-7oqfod62 121 8 detection detection NN cord-255011-7oqfod62 121 9 of of IN cord-255011-7oqfod62 121 10 CRCoV crcov NN cord-255011-7oqfod62 121 11 infections infection NNS cord-255011-7oqfod62 121 12 if if IN cord-255011-7oqfod62 121 13 paired pair VBN cord-255011-7oqfod62 121 14 serum serum NN cord-255011-7oqfod62 121 15 samples sample NNS cord-255011-7oqfod62 121 16 are be VBP cord-255011-7oqfod62 121 17 collected collect VBN cord-255011-7oqfod62 121 18 during during IN cord-255011-7oqfod62 121 19 an an DT cord-255011-7oqfod62 121 20 outbreak outbreak NN cord-255011-7oqfod62 121 21 of of IN cord-255011-7oqfod62 121 22 respiratory respiratory JJ cord-255011-7oqfod62 121 23 disease disease NN cord-255011-7oqfod62 121 24 and and CC cord-255011-7oqfod62 121 25 at at IN cord-255011-7oqfod62 121 26 least least JJS cord-255011-7oqfod62 121 27 2 2 CD cord-255011-7oqfod62 121 28 to to TO cord-255011-7oqfod62 121 29 3 3 CD cord-255011-7oqfod62 121 30 weeks week NNS cord-255011-7oqfod62 121 31 afterward afterward RB cord-255011-7oqfod62 121 32 . . . cord-255011-7oqfod62 122 1 The the DT cord-255011-7oqfod62 122 2 high high JJ cord-255011-7oqfod62 122 3 similarity similarity NN cord-255011-7oqfod62 122 4 of of IN cord-255011-7oqfod62 122 5 CRCoV crcov NN cord-255011-7oqfod62 122 6 and and CC cord-255011-7oqfod62 122 7 BCoV BCoV NNP cord-255011-7oqfod62 122 8 allows allow VBZ cord-255011-7oqfod62 122 9 the the DT cord-255011-7oqfod62 122 10 use use NN cord-255011-7oqfod62 122 11 of of IN cord-255011-7oqfod62 122 12 BCoV BCoV NNP cord-255011-7oqfod62 122 13 antigens antigen NNS cord-255011-7oqfod62 122 14 to to TO cord-255011-7oqfod62 122 15 test test VB cord-255011-7oqfod62 122 16 canine canine JJ cord-255011-7oqfod62 122 17 sera sera NNP cord-255011-7oqfod62 122 18 by by IN cord-255011-7oqfod62 122 19 ELISA ELISA NNP cord-255011-7oqfod62 122 20 [ [ -LRB- cord-255011-7oqfod62 122 21 9 9 CD cord-255011-7oqfod62 122 22 , , , cord-255011-7oqfod62 122 23 26 26 CD cord-255011-7oqfod62 122 24 ] ] -RRB- cord-255011-7oqfod62 122 25 . . . cord-255011-7oqfod62 123 1 Similarly similarly RB cord-255011-7oqfod62 123 2 , , , cord-255011-7oqfod62 123 3 BCoV BCoV NNP cord-255011-7oqfod62 123 4 has have VBZ cord-255011-7oqfod62 123 5 been be VBN cord-255011-7oqfod62 123 6 used use VBN cord-255011-7oqfod62 123 7 instead instead RB cord-255011-7oqfod62 123 8 of of IN cord-255011-7oqfod62 123 9 CRCoV crcov NN cord-255011-7oqfod62 123 10 in in IN cord-255011-7oqfod62 123 11 serum serum NN cord-255011-7oqfod62 123 12 neutralization neutralization NN cord-255011-7oqfod62 123 13 tests test NNS cord-255011-7oqfod62 123 14 [ [ -LRB- cord-255011-7oqfod62 123 15 23 23 CD cord-255011-7oqfod62 123 16 ] ] -RRB- cord-255011-7oqfod62 123 17 . . . cord-255011-7oqfod62 124 1 A a DT cord-255011-7oqfod62 124 2 hemagglutination hemagglutination NN cord-255011-7oqfod62 124 3 inhibition inhibition NN cord-255011-7oqfod62 124 4 test test NN cord-255011-7oqfod62 124 5 based base VBN cord-255011-7oqfod62 124 6 on on IN cord-255011-7oqfod62 124 7 BCoV BCoV NNP cord-255011-7oqfod62 124 8 has have VBZ cord-255011-7oqfod62 124 9 also also RB cord-255011-7oqfod62 124 10 been be VBN cord-255011-7oqfod62 124 11 evaluated evaluate VBN cord-255011-7oqfod62 124 12 but but CC cord-255011-7oqfod62 124 13 was be VBD cord-255011-7oqfod62 124 14 assessed assess VBN cord-255011-7oqfod62 124 15 as as IN cord-255011-7oqfod62 124 16 having have VBG cord-255011-7oqfod62 124 17 poor poor JJ cord-255011-7oqfod62 124 18 sensitivity sensitivity NN cord-255011-7oqfod62 124 19 and and CC cord-255011-7oqfod62 124 20 specificity specificity NN cord-255011-7oqfod62 124 21 compared compare VBN cord-255011-7oqfod62 124 22 with with IN cord-255011-7oqfod62 124 23 an an DT cord-255011-7oqfod62 124 24 ELISA ELISA NNP cord-255011-7oqfod62 124 25 based base VBN cord-255011-7oqfod62 124 26 on on IN cord-255011-7oqfod62 124 27 BCoV BCoV NNP cord-255011-7oqfod62 124 28 [ [ -LRB- cord-255011-7oqfod62 124 29 26 26 CD cord-255011-7oqfod62 124 30 ] ] -RRB- cord-255011-7oqfod62 124 31 . . . cord-255011-7oqfod62 125 1 An an DT cord-255011-7oqfod62 125 2 ELISA ELISA NNP cord-255011-7oqfod62 125 3 assay assay NN cord-255011-7oqfod62 125 4 using use VBG cord-255011-7oqfod62 125 5 CRCoV crcov NN cord-255011-7oqfod62 125 6 antigen antigen NN cord-255011-7oqfod62 125 7 was be VBD cord-255011-7oqfod62 125 8 found find VBN cord-255011-7oqfod62 125 9 to to TO cord-255011-7oqfod62 125 10 have have VB cord-255011-7oqfod62 125 11 slightly slightly RB cord-255011-7oqfod62 125 12 higher high JJR cord-255011-7oqfod62 125 13 sensitivity sensitivity NN cord-255011-7oqfod62 125 14 and and CC cord-255011-7oqfod62 125 15 specificity specificity NN cord-255011-7oqfod62 125 16 compared compare VBN cord-255011-7oqfod62 125 17 with with IN cord-255011-7oqfod62 125 18 an an DT cord-255011-7oqfod62 125 19 assay assay NN cord-255011-7oqfod62 125 20 based base VBN cord-255011-7oqfod62 125 21 on on IN cord-255011-7oqfod62 125 22 BCoV BCoV NNP cord-255011-7oqfod62 125 23 ; ; : cord-255011-7oqfod62 125 24 however however RB cord-255011-7oqfod62 125 25 , , , cord-255011-7oqfod62 125 26 overall overall RB cord-255011-7oqfod62 125 27 , , , cord-255011-7oqfod62 125 28 the the DT cord-255011-7oqfod62 125 29 agreement agreement NN cord-255011-7oqfod62 125 30 between between IN cord-255011-7oqfod62 125 31 the the DT cord-255011-7oqfod62 125 32 two two CD cord-255011-7oqfod62 125 33 ELISA ELISA NNP cord-255011-7oqfod62 125 34 tests test NNS cord-255011-7oqfod62 125 35 was be VBD cord-255011-7oqfod62 125 36 high high JJ cord-255011-7oqfod62 125 37 [ [ -LRB- cord-255011-7oqfod62 125 38 24 24 CD cord-255011-7oqfod62 125 39 ] ] -RRB- cord-255011-7oqfod62 125 40 . . . cord-255011-7oqfod62 126 1 Antibodies antibody NNS cord-255011-7oqfod62 126 2 to to IN cord-255011-7oqfod62 126 3 CRCoV crcov NN cord-255011-7oqfod62 126 4 have have VBP cord-255011-7oqfod62 126 5 also also RB cord-255011-7oqfod62 126 6 been be VBN cord-255011-7oqfod62 126 7 detected detect VBN cord-255011-7oqfod62 126 8 by by IN cord-255011-7oqfod62 126 9 using use VBG cord-255011-7oqfod62 126 10 an an DT cord-255011-7oqfod62 126 11 immunofluorescence immunofluorescence JJ cord-255011-7oqfod62 126 12 assay assay NN cord-255011-7oqfod62 126 13 on on IN cord-255011-7oqfod62 126 14 CRCoV crcov NN cord-255011-7oqfod62 126 15 - - HYPH cord-255011-7oqfod62 126 16 infected infect VBN cord-255011-7oqfod62 126 17 HRT-18 HRT-18 NNP cord-255011-7oqfod62 126 18 cells cell NNS cord-255011-7oqfod62 126 19 [ [ -LRB- cord-255011-7oqfod62 126 20 24 24 CD cord-255011-7oqfod62 126 21 ] ] -RRB- cord-255011-7oqfod62 126 22 . . . cord-255011-7oqfod62 127 1 Specific specific JJ cord-255011-7oqfod62 127 2 tests test NNS cord-255011-7oqfod62 127 3 for for IN cord-255011-7oqfod62 127 4 CRCoV crcov NN cord-255011-7oqfod62 127 5 are be VBP cord-255011-7oqfod62 127 6 becoming become VBG cord-255011-7oqfod62 127 7 increasingly increasingly RB cord-255011-7oqfod62 127 8 available available JJ cord-255011-7oqfod62 127 9 ; ; : cord-255011-7oqfod62 127 10 however however RB cord-255011-7oqfod62 127 11 , , , cord-255011-7oqfod62 127 12 most most JJS cord-255011-7oqfod62 127 13 assays assay NNS cord-255011-7oqfod62 127 14 offered offer VBN cord-255011-7oqfod62 127 15 for for IN cord-255011-7oqfod62 127 16 the the DT cord-255011-7oqfod62 127 17 detection detection NN cord-255011-7oqfod62 127 18 of of IN cord-255011-7oqfod62 127 19 coronaviruses coronaviruse NNS cord-255011-7oqfod62 127 20 in in IN cord-255011-7oqfod62 127 21 dogs dog NNS cord-255011-7oqfod62 127 22 are be VBP cord-255011-7oqfod62 127 23 specific specific JJ cord-255011-7oqfod62 127 24 for for IN cord-255011-7oqfod62 127 25 enteric enteric JJ cord-255011-7oqfod62 127 26 CCoV. ccov. NN cord-255011-7oqfod62 127 27 Antibodies Antibodies NNP cord-255011-7oqfod62 127 28 to to IN cord-255011-7oqfod62 127 29 CRCoV crcov NN cord-255011-7oqfod62 127 30 do do VBP cord-255011-7oqfod62 127 31 not not RB cord-255011-7oqfod62 127 32 cross cross VB cord-255011-7oqfod62 127 33 - - JJ cord-255011-7oqfod62 127 34 react react VB cord-255011-7oqfod62 127 35 with with IN cord-255011-7oqfod62 127 36 enteric enteric JJ cord-255011-7oqfod62 127 37 CCoV. ccov. NN cord-255011-7oqfod62 128 1 It -PRON- PRP cord-255011-7oqfod62 128 2 is be VBZ cord-255011-7oqfod62 128 3 important important JJ cord-255011-7oqfod62 128 4 to to TO cord-255011-7oqfod62 128 5 use use VB cord-255011-7oqfod62 128 6 an an DT cord-255011-7oqfod62 128 7 assay assay NN cord-255011-7oqfod62 128 8 capable capable JJ cord-255011-7oqfod62 128 9 of of IN cord-255011-7oqfod62 128 10 detecting detect VBG cord-255011-7oqfod62 128 11 antibodies antibody NNS cord-255011-7oqfod62 128 12 to to IN cord-255011-7oqfod62 128 13 CRCoV crcov CD cord-255011-7oqfod62 128 14 or or CC cord-255011-7oqfod62 128 15 related relate VBN cord-255011-7oqfod62 128 16 group group NN cord-255011-7oqfod62 128 17 2 2 CD cord-255011-7oqfod62 128 18 coronaviruses coronaviruse NNS cord-255011-7oqfod62 128 19 , , , cord-255011-7oqfod62 128 20 such such JJ cord-255011-7oqfod62 128 21 as as IN cord-255011-7oqfod62 128 22 BCoV. bcov. CD cord-255011-7oqfod62 128 23 Consequently consequently RB cord-255011-7oqfod62 128 24 , , , cord-255011-7oqfod62 128 25 the the DT cord-255011-7oqfod62 128 26 requirement requirement NN cord-255011-7oqfod62 128 27 for for IN cord-255011-7oqfod62 128 28 CRCoV crcov NN cord-255011-7oqfod62 128 29 detection detection NN cord-255011-7oqfod62 128 30 should should MD cord-255011-7oqfod62 128 31 be be VB cord-255011-7oqfod62 128 32 discussed discuss VBN cord-255011-7oqfod62 128 33 with with IN cord-255011-7oqfod62 128 34 the the DT cord-255011-7oqfod62 128 35 diagnostic diagnostic JJ cord-255011-7oqfod62 128 36 laboratory laboratory NN cord-255011-7oqfod62 128 37 before before IN cord-255011-7oqfod62 128 38 submitting submit VBG cord-255011-7oqfod62 128 39 samples sample NNS cord-255011-7oqfod62 128 40 for for IN cord-255011-7oqfod62 128 41 RT RT NNP cord-255011-7oqfod62 128 42 - - HYPH cord-255011-7oqfod62 128 43 PCR PCR NNP cord-255011-7oqfod62 128 44 , , , cord-255011-7oqfod62 128 45 virus virus NN cord-255011-7oqfod62 128 46 isolation isolation NN cord-255011-7oqfod62 128 47 , , , cord-255011-7oqfod62 128 48 or or CC cord-255011-7oqfod62 128 49 serology serology NN cord-255011-7oqfod62 128 50 . . . cord-255011-7oqfod62 129 1 There there EX cord-255011-7oqfod62 129 2 is be VBZ cord-255011-7oqfod62 129 3 no no DT cord-255011-7oqfod62 129 4 specific specific JJ cord-255011-7oqfod62 129 5 treatment treatment NN cord-255011-7oqfod62 129 6 for for IN cord-255011-7oqfod62 129 7 infections infection NNS cord-255011-7oqfod62 129 8 caused cause VBN cord-255011-7oqfod62 129 9 by by IN cord-255011-7oqfod62 129 10 CRCoV. CRCoV. NNP cord-255011-7oqfod62 130 1 As as IN cord-255011-7oqfod62 130 2 for for IN cord-255011-7oqfod62 130 3 other other JJ cord-255011-7oqfod62 130 4 causes cause NNS cord-255011-7oqfod62 130 5 of of IN cord-255011-7oqfod62 130 6 CIRD CIRD NNP cord-255011-7oqfod62 130 7 , , , cord-255011-7oqfod62 130 8 patient patient JJ cord-255011-7oqfod62 130 9 care care NN cord-255011-7oqfod62 130 10 should should MD cord-255011-7oqfod62 130 11 focus focus VB cord-255011-7oqfod62 130 12 on on IN cord-255011-7oqfod62 130 13 the the DT cord-255011-7oqfod62 130 14 prevention prevention NN cord-255011-7oqfod62 130 15 and and CC cord-255011-7oqfod62 130 16 treatment treatment NN cord-255011-7oqfod62 130 17 of of IN cord-255011-7oqfod62 130 18 bacterial bacterial JJ cord-255011-7oqfod62 130 19 infections infection NNS cord-255011-7oqfod62 130 20 . . . cord-255011-7oqfod62 131 1 Although although IN cord-255011-7oqfod62 131 2 many many JJ cord-255011-7oqfod62 131 3 pathogens pathogen NNS cord-255011-7oqfod62 131 4 involved involve VBN cord-255011-7oqfod62 131 5 in in IN cord-255011-7oqfod62 131 6 CIRD CIRD NNP cord-255011-7oqfod62 131 7 are be VBP cord-255011-7oqfod62 131 8 reported report VBN cord-255011-7oqfod62 131 9 to to TO cord-255011-7oqfod62 131 10 be be VB cord-255011-7oqfod62 131 11 associated associate VBN cord-255011-7oqfod62 131 12 with with IN cord-255011-7oqfod62 131 13 mild mild JJ cord-255011-7oqfod62 131 14 clinical clinical JJ cord-255011-7oqfod62 131 15 disease disease NN cord-255011-7oqfod62 131 16 , , , cord-255011-7oqfod62 131 17 it -PRON- PRP cord-255011-7oqfod62 131 18 is be VBZ cord-255011-7oqfod62 131 19 important important JJ cord-255011-7oqfod62 131 20 to to TO cord-255011-7oqfod62 131 21 bear bear VB cord-255011-7oqfod62 131 22 in in IN cord-255011-7oqfod62 131 23 mind mind NN cord-255011-7oqfod62 131 24 that that IN cord-255011-7oqfod62 131 25 mixed mixed JJ cord-255011-7oqfod62 131 26 infections infection NNS cord-255011-7oqfod62 131 27 can can MD cord-255011-7oqfod62 131 28 potentially potentially RB cord-255011-7oqfod62 131 29 be be VB cord-255011-7oqfod62 131 30 much much RB cord-255011-7oqfod62 131 31 more more RBR cord-255011-7oqfod62 131 32 severe severe JJ cord-255011-7oqfod62 131 33 . . . cord-255011-7oqfod62 132 1 Patients patient NNS cord-255011-7oqfod62 132 2 should should MD cord-255011-7oqfod62 132 3 be be VB cord-255011-7oqfod62 132 4 monitored monitor VBN cord-255011-7oqfod62 132 5 , , , cord-255011-7oqfod62 132 6 because because IN cord-255011-7oqfod62 132 7 the the DT cord-255011-7oqfod62 132 8 condition condition NN cord-255011-7oqfod62 132 9 may may MD cord-255011-7oqfod62 132 10 rapidly rapidly RB cord-255011-7oqfod62 132 11 worsen worsen VB cord-255011-7oqfod62 132 12 . . . cord-255011-7oqfod62 133 1 Severe severe JJ cord-255011-7oqfod62 133 2 cases case NNS cord-255011-7oqfod62 133 3 of of IN cord-255011-7oqfod62 133 4 CIRD CIRD NNP cord-255011-7oqfod62 133 5 with with IN cord-255011-7oqfod62 133 6 sudden sudden JJ cord-255011-7oqfod62 133 7 death death NN cord-255011-7oqfod62 133 8 have have VBP cord-255011-7oqfod62 133 9 been be VBN cord-255011-7oqfod62 133 10 reported report VBN cord-255011-7oqfod62 133 11 after after IN cord-255011-7oqfod62 133 12 infections infection NNS cord-255011-7oqfod62 133 13 with with IN cord-255011-7oqfod62 133 14 Streptococcus streptococcus NN cord-255011-7oqfod62 133 15 equi equi NN cord-255011-7oqfod62 133 16 subsp subsp NN cord-255011-7oqfod62 133 17 . . . cord-255011-7oqfod62 134 1 zooepidemicus zooepidemicus NNP cord-255011-7oqfod62 134 2 [ [ -LRB- cord-255011-7oqfod62 134 3 8 8 CD cord-255011-7oqfod62 134 4 ] ] -RRB- cord-255011-7oqfod62 134 5 . . . cord-255011-7oqfod62 135 1 To to IN cord-255011-7oqfod62 135 2 date date NN cord-255011-7oqfod62 135 3 , , , cord-255011-7oqfod62 135 4 no no DT cord-255011-7oqfod62 135 5 vaccines vaccine NNS cord-255011-7oqfod62 135 6 against against IN cord-255011-7oqfod62 135 7 CRCoV crcov NN cord-255011-7oqfod62 135 8 are be VBP cord-255011-7oqfod62 135 9 available available JJ cord-255011-7oqfod62 135 10 . . . cord-255011-7oqfod62 136 1 Vaccines vaccine NNS cord-255011-7oqfod62 136 2 against against IN cord-255011-7oqfod62 136 3 CCoV CCoV NNP cord-255011-7oqfod62 136 4 are be VBP cord-255011-7oqfod62 136 5 unlikely unlikely JJ cord-255011-7oqfod62 136 6 to to TO cord-255011-7oqfod62 136 7 protect protect VB cord-255011-7oqfod62 136 8 against against IN cord-255011-7oqfod62 136 9 infection infection NN cord-255011-7oqfod62 136 10 with with IN cord-255011-7oqfod62 136 11 CRCoV crcov NN cord-255011-7oqfod62 136 12 because because IN cord-255011-7oqfod62 136 13 of of IN cord-255011-7oqfod62 136 14 a a DT cord-255011-7oqfod62 136 15 low low JJ cord-255011-7oqfod62 136 16 similarity similarity NN cord-255011-7oqfod62 136 17 in in IN cord-255011-7oqfod62 136 18 the the DT cord-255011-7oqfod62 136 19 spike spike NN cord-255011-7oqfod62 136 20 proteins protein NNS cord-255011-7oqfod62 136 21 that that WDT cord-255011-7oqfod62 136 22 are be VBP cord-255011-7oqfod62 136 23 the the DT cord-255011-7oqfod62 136 24 major major JJ cord-255011-7oqfod62 136 25 immunogenic immunogenic JJ cord-255011-7oqfod62 136 26 proteins protein NNS cord-255011-7oqfod62 136 27 of of IN cord-255011-7oqfod62 136 28 coronaviruses coronaviruse NNS cord-255011-7oqfod62 136 29 . . . cord-255011-7oqfod62 137 1 Vaccines vaccine NNS cord-255011-7oqfod62 137 2 against against IN cord-255011-7oqfod62 137 3 other other JJ cord-255011-7oqfod62 137 4 respiratory respiratory JJ cord-255011-7oqfod62 137 5 pathogens pathogen NNS cord-255011-7oqfod62 137 6 may may MD cord-255011-7oqfod62 137 7 not not RB cord-255011-7oqfod62 137 8 prevent prevent VB cord-255011-7oqfod62 137 9 CIRD CIRD NNP cord-255011-7oqfod62 137 10 , , , cord-255011-7oqfod62 137 11 particularly particularly RB cord-255011-7oqfod62 137 12 in in IN cord-255011-7oqfod62 137 13 large large JJ cord-255011-7oqfod62 137 14 populations population NNS cord-255011-7oqfod62 137 15 because because IN cord-255011-7oqfod62 137 16 of of IN cord-255011-7oqfod62 137 17 the the DT cord-255011-7oqfod62 137 18 presence presence NN cord-255011-7oqfod62 137 19 of of IN cord-255011-7oqfod62 137 20 other other JJ cord-255011-7oqfod62 137 21 infectious infectious JJ cord-255011-7oqfod62 137 22 agents agent NNS cord-255011-7oqfod62 137 23 . . . cord-255011-7oqfod62 138 1 Nevertheless nevertheless RB cord-255011-7oqfod62 138 2 , , , cord-255011-7oqfod62 138 3 they -PRON- PRP cord-255011-7oqfod62 138 4 have have VBP cord-255011-7oqfod62 138 5 the the DT cord-255011-7oqfod62 138 6 potential potential NN cord-255011-7oqfod62 138 7 to to TO cord-255011-7oqfod62 138 8 reduce reduce VB cord-255011-7oqfod62 138 9 the the DT cord-255011-7oqfod62 138 10 number number NN cord-255011-7oqfod62 138 11 of of IN cord-255011-7oqfod62 138 12 circulating circulate VBG cord-255011-7oqfod62 138 13 pathogens pathogen NNS cord-255011-7oqfod62 138 14 if if IN cord-255011-7oqfod62 138 15 given give VBN cord-255011-7oqfod62 138 16 to to IN cord-255011-7oqfod62 138 17 all all DT cord-255011-7oqfod62 138 18 dogs dog NNS cord-255011-7oqfod62 138 19 on on IN cord-255011-7oqfod62 138 20 entry entry NN cord-255011-7oqfod62 138 21 . . . cord-255011-7oqfod62 139 1 Vaccines vaccine NNS cord-255011-7oqfod62 139 2 against against IN cord-255011-7oqfod62 139 3 canine canine JJ cord-255011-7oqfod62 139 4 distemper distemper NN cord-255011-7oqfod62 139 5 virus virus NN cord-255011-7oqfod62 139 6 and and CC cord-255011-7oqfod62 139 7 CAV CAV NNP cord-255011-7oqfod62 139 8 are be VBP cord-255011-7oqfod62 139 9 widely widely RB cord-255011-7oqfod62 139 10 used use VBN cord-255011-7oqfod62 139 11 , , , cord-255011-7oqfod62 139 12 and and CC cord-255011-7oqfod62 139 13 this this DT cord-255011-7oqfod62 139 14 may may MD cord-255011-7oqfod62 139 15 account account VB cord-255011-7oqfod62 139 16 for for IN cord-255011-7oqfod62 139 17 the the DT cord-255011-7oqfod62 139 18 inability inability NN cord-255011-7oqfod62 139 19 to to TO cord-255011-7oqfod62 139 20 identify identify VB cord-255011-7oqfod62 139 21 either either DT cord-255011-7oqfod62 139 22 virus virus NN cord-255011-7oqfod62 139 23 in in IN cord-255011-7oqfod62 139 24 a a DT cord-255011-7oqfod62 139 25 population population NN cord-255011-7oqfod62 139 26 with with IN cord-255011-7oqfod62 139 27 enzootic enzootic JJ cord-255011-7oqfod62 139 28 CIRD CIRD NNP cord-255011-7oqfod62 139 29 [ [ -LRB- cord-255011-7oqfod62 139 30 28 28 CD cord-255011-7oqfod62 139 31 ] ] -RRB- cord-255011-7oqfod62 139 32 . . . cord-255011-7oqfod62 140 1 Although although IN cord-255011-7oqfod62 140 2 no no DT cord-255011-7oqfod62 140 3 specific specific JJ cord-255011-7oqfod62 140 4 tests test NNS cord-255011-7oqfod62 140 5 have have VBP cord-255011-7oqfod62 140 6 been be VBN cord-255011-7oqfod62 140 7 performed perform VBN cord-255011-7oqfod62 140 8 to to TO cord-255011-7oqfod62 140 9 determine determine VB cord-255011-7oqfod62 140 10 the the DT cord-255011-7oqfod62 140 11 stability stability NN cord-255011-7oqfod62 140 12 of of IN cord-255011-7oqfod62 140 13 CRCoV crcov NN cord-255011-7oqfod62 140 14 in in IN cord-255011-7oqfod62 140 15 the the DT cord-255011-7oqfod62 140 16 environment environment NN cord-255011-7oqfod62 140 17 , , , cord-255011-7oqfod62 140 18 other other JJ cord-255011-7oqfod62 140 19 coronaviruses coronaviruse NNS cord-255011-7oqfod62 140 20 have have VBP cord-255011-7oqfod62 140 21 been be VBN cord-255011-7oqfod62 140 22 reported report VBN cord-255011-7oqfod62 140 23 to to TO cord-255011-7oqfod62 140 24 remain remain VB cord-255011-7oqfod62 140 25 infectious infectious JJ cord-255011-7oqfod62 140 26 in in IN cord-255011-7oqfod62 140 27 respiratory respiratory JJ cord-255011-7oqfod62 140 28 secretions secretion NNS cord-255011-7oqfod62 140 29 for for IN cord-255011-7oqfod62 140 30 more more JJR cord-255011-7oqfod62 140 31 than than IN cord-255011-7oqfod62 140 32 7 7 CD cord-255011-7oqfod62 140 33 days day NNS cord-255011-7oqfod62 140 34 [ [ -LRB- cord-255011-7oqfod62 140 35 31 31 CD cord-255011-7oqfod62 140 36 ] ] -RRB- cord-255011-7oqfod62 140 37 . . . cord-255011-7oqfod62 141 1 Thorough thorough JJ cord-255011-7oqfod62 141 2 cleaning cleaning NN cord-255011-7oqfod62 141 3 and and CC cord-255011-7oqfod62 141 4 disinfection disinfection NN cord-255011-7oqfod62 141 5 of of IN cord-255011-7oqfod62 141 6 kennels kennel NNS cord-255011-7oqfod62 141 7 after after IN cord-255011-7oqfod62 141 8 outbreaks outbreak NNS cord-255011-7oqfod62 141 9 of of IN cord-255011-7oqfod62 141 10 respiratory respiratory JJ cord-255011-7oqfod62 141 11 disease disease NN cord-255011-7oqfod62 141 12 are be VBP cord-255011-7oqfod62 141 13 therefore therefore RB cord-255011-7oqfod62 141 14 required require VBN cord-255011-7oqfod62 141 15 . . . cord-255011-7oqfod62 142 1 Coronaviruses coronaviruse NNS cord-255011-7oqfod62 142 2 are be VBP cord-255011-7oqfod62 142 3 inactivated inactivate VBN cord-255011-7oqfod62 142 4 by by IN cord-255011-7oqfod62 142 5 disinfectants disinfectant NNS cord-255011-7oqfod62 142 6 commonly commonly RB cord-255011-7oqfod62 142 7 used use VBN cord-255011-7oqfod62 142 8 for for IN cord-255011-7oqfod62 142 9 surface surface NN cord-255011-7oqfod62 142 10 disinfection disinfection NN cord-255011-7oqfod62 142 11 in in IN cord-255011-7oqfod62 142 12 kennels kennel NNS cord-255011-7oqfod62 142 13 and and CC cord-255011-7oqfod62 142 14 veterinary veterinary JJ cord-255011-7oqfod62 142 15 practices practice NNS cord-255011-7oqfod62 142 16 . . . cord-255011-7oqfod62 143 1 The the DT cord-255011-7oqfod62 143 2 role role NN cord-255011-7oqfod62 143 3 of of IN cord-255011-7oqfod62 143 4 fecal fecal JJ cord-255011-7oqfod62 143 5 shedding shedding NN cord-255011-7oqfod62 143 6 and and CC cord-255011-7oqfod62 143 7 the the DT cord-255011-7oqfod62 143 8 potential potential JJ cord-255011-7oqfod62 143 9 transmission transmission NN cord-255011-7oqfod62 143 10 of of IN cord-255011-7oqfod62 143 11 CRCoV crcov NN cord-255011-7oqfod62 143 12 among among IN cord-255011-7oqfod62 143 13 dogs dog NNS cord-255011-7oqfod62 143 14 sharing share VBG cord-255011-7oqfod62 143 15 common common JJ cord-255011-7oqfod62 143 16 facilities facility NNS cord-255011-7oqfod62 143 17 , , , cord-255011-7oqfod62 143 18 such such JJ cord-255011-7oqfod62 143 19 as as IN cord-255011-7oqfod62 143 20 outdoor outdoor JJ cord-255011-7oqfod62 143 21 runs run NNS cord-255011-7oqfod62 143 22 , , , cord-255011-7oqfod62 143 23 have have VBP cord-255011-7oqfod62 143 24 yet yet RB cord-255011-7oqfod62 143 25 to to TO cord-255011-7oqfod62 143 26 be be VB cord-255011-7oqfod62 143 27 resolved resolve VBN cord-255011-7oqfod62 143 28 . . . cord-255011-7oqfod62 144 1 Other other JJ cord-255011-7oqfod62 144 2 generally generally RB cord-255011-7oqfod62 144 3 recommended recommend VBN cord-255011-7oqfod62 144 4 measures measure NNS cord-255011-7oqfod62 144 5 , , , cord-255011-7oqfod62 144 6 such such JJ cord-255011-7oqfod62 144 7 as as IN cord-255011-7oqfod62 144 8 washing wash VBG cord-255011-7oqfod62 144 9 one one PRP cord-255011-7oqfod62 144 10 's 's POS cord-255011-7oqfod62 144 11 hands hand NNS cord-255011-7oqfod62 144 12 after after IN cord-255011-7oqfod62 144 13 handling handle VBG cord-255011-7oqfod62 144 14 animals animal NNS cord-255011-7oqfod62 144 15 with with IN cord-255011-7oqfod62 144 16 respiratory respiratory JJ cord-255011-7oqfod62 144 17 disease disease NN cord-255011-7oqfod62 144 18 should should MD cord-255011-7oqfod62 144 19 also also RB cord-255011-7oqfod62 144 20 help help VB cord-255011-7oqfod62 144 21 to to TO cord-255011-7oqfod62 144 22 reduce reduce VB cord-255011-7oqfod62 144 23 the the DT cord-255011-7oqfod62 144 24 spread spread NN cord-255011-7oqfod62 144 25 of of IN cord-255011-7oqfod62 144 26 the the DT cord-255011-7oqfod62 144 27 virus virus NN cord-255011-7oqfod62 144 28 . . . cord-255011-7oqfod62 145 1 CRCoV CRCoV NNP cord-255011-7oqfod62 145 2 has have VBZ cord-255011-7oqfod62 145 3 been be VBN cord-255011-7oqfod62 145 4 detected detect VBN cord-255011-7oqfod62 145 5 in in IN cord-255011-7oqfod62 145 6 dogs dog NNS cord-255011-7oqfod62 145 7 up up IN cord-255011-7oqfod62 145 8 to to TO cord-255011-7oqfod62 145 9 4 4 CD cord-255011-7oqfod62 145 10 weeks week NNS cord-255011-7oqfod62 145 11 after after IN cord-255011-7oqfod62 145 12 entry entry NN cord-255011-7oqfod62 145 13 into into IN cord-255011-7oqfod62 145 14 a a DT cord-255011-7oqfod62 145 15 kennel kennel NN cord-255011-7oqfod62 145 16 . . . cord-255011-7oqfod62 146 1 Because because IN cord-255011-7oqfod62 146 2 the the DT cord-255011-7oqfod62 146 3 time time NN cord-255011-7oqfod62 146 4 of of IN cord-255011-7oqfod62 146 5 infection infection NN cord-255011-7oqfod62 146 6 in in IN cord-255011-7oqfod62 146 7 those those DT cord-255011-7oqfod62 146 8 naturally naturally RB cord-255011-7oqfod62 146 9 occurring occur VBG cord-255011-7oqfod62 146 10 cases case NNS cord-255011-7oqfod62 146 11 is be VBZ cord-255011-7oqfod62 146 12 not not RB cord-255011-7oqfod62 146 13 known know VBN cord-255011-7oqfod62 146 14 , , , cord-255011-7oqfod62 146 15 it -PRON- PRP cord-255011-7oqfod62 146 16 is be VBZ cord-255011-7oqfod62 146 17 unclear unclear JJ cord-255011-7oqfod62 146 18 how how WRB cord-255011-7oqfod62 146 19 long long JJ cord-255011-7oqfod62 146 20 CRCoV crcov NN cord-255011-7oqfod62 146 21 is be VBZ cord-255011-7oqfod62 146 22 being be VBG cord-255011-7oqfod62 146 23 shed shed VBN cord-255011-7oqfod62 146 24 . . . cord-255011-7oqfod62 147 1 After after IN cord-255011-7oqfod62 147 2 experimental experimental JJ cord-255011-7oqfod62 147 3 infection infection NN cord-255011-7oqfod62 147 4 of of IN cord-255011-7oqfod62 147 5 dogs dog NNS cord-255011-7oqfod62 147 6 with with IN cord-255011-7oqfod62 147 7 BCoV BCoV NNP cord-255011-7oqfod62 147 8 , , , cord-255011-7oqfod62 147 9 the the DT cord-255011-7oqfod62 147 10 virus virus NN cord-255011-7oqfod62 147 11 was be VBD cord-255011-7oqfod62 147 12 detected detect VBN cord-255011-7oqfod62 147 13 in in IN cord-255011-7oqfod62 147 14 a a DT cord-255011-7oqfod62 147 15 rectal rectal JJ cord-255011-7oqfod62 147 16 swab swab NN cord-255011-7oqfod62 147 17 after after IN cord-255011-7oqfod62 147 18 11 11 CD cord-255011-7oqfod62 147 19 days day NNS cord-255011-7oqfod62 147 20 [ [ -LRB- cord-255011-7oqfod62 147 21 29 29 CD cord-255011-7oqfod62 147 22 ] ] -RRB- cord-255011-7oqfod62 147 23 . . . cord-255011-7oqfod62 148 1 Quarantine quarantine NN cord-255011-7oqfod62 148 2 of of IN cord-255011-7oqfod62 148 3 newly newly RB cord-255011-7oqfod62 148 4 arriving arrive VBG cord-255011-7oqfod62 148 5 dogs dog NNS cord-255011-7oqfod62 148 6 , , , cord-255011-7oqfod62 148 7 if if IN cord-255011-7oqfod62 148 8 feasible feasible JJ cord-255011-7oqfod62 148 9 in in IN cord-255011-7oqfod62 148 10 training training NN cord-255011-7oqfod62 148 11 kennels kennel NNS cord-255011-7oqfod62 148 12 or or CC cord-255011-7oqfod62 148 13 shelters shelter NNS cord-255011-7oqfod62 148 14 , , , cord-255011-7oqfod62 148 15 should should MD cord-255011-7oqfod62 148 16 therefore therefore RB cord-255011-7oqfod62 148 17 last last VB cord-255011-7oqfod62 148 18 for for IN cord-255011-7oqfod62 148 19 at at RB cord-255011-7oqfod62 148 20 least least JJS cord-255011-7oqfod62 148 21 2 2 CD cord-255011-7oqfod62 148 22 weeks week NNS cord-255011-7oqfod62 148 23 . . . cord-255011-7oqfod62 149 1 Group group NN cord-255011-7oqfod62 149 2 1 1 CD cord-255011-7oqfod62 149 3 CCoVs CCoVs NNP cord-255011-7oqfod62 149 4 , , , cord-255011-7oqfod62 149 5 referred refer VBD cord-255011-7oqfod62 149 6 to to IN cord-255011-7oqfod62 149 7 in in IN cord-255011-7oqfod62 149 8 this this DT cord-255011-7oqfod62 149 9 article article NN cord-255011-7oqfod62 149 10 as as IN cord-255011-7oqfod62 149 11 CCoVs CCoVs NNP cord-255011-7oqfod62 149 12 , , , cord-255011-7oqfod62 149 13 have have VBP cord-255011-7oqfod62 149 14 previously previously RB cord-255011-7oqfod62 149 15 been be VBN cord-255011-7oqfod62 149 16 associated associate VBN cord-255011-7oqfod62 149 17 with with IN cord-255011-7oqfod62 149 18 mild mild JJ cord-255011-7oqfod62 149 19 gastroenteritis gastroenteritis NN cord-255011-7oqfod62 149 20 . . . cord-255011-7oqfod62 150 1 According accord VBG cord-255011-7oqfod62 150 2 to to IN cord-255011-7oqfod62 150 3 their -PRON- PRP$ cord-255011-7oqfod62 150 4 similarity similarity NN cord-255011-7oqfod62 150 5 to to IN cord-255011-7oqfod62 150 6 feline feline JJ cord-255011-7oqfod62 150 7 coronaviruses coronaviruse NNS cord-255011-7oqfod62 150 8 , , , cord-255011-7oqfod62 150 9 they -PRON- PRP cord-255011-7oqfod62 150 10 are be VBP cord-255011-7oqfod62 150 11 divided divide VBN cord-255011-7oqfod62 150 12 into into IN cord-255011-7oqfod62 150 13 type type NN cord-255011-7oqfod62 150 14 I -PRON- PRP cord-255011-7oqfod62 150 15 ( ( -LRB- cord-255011-7oqfod62 150 16 related relate VBN cord-255011-7oqfod62 150 17 to to IN cord-255011-7oqfod62 150 18 feline feline JJ cord-255011-7oqfod62 150 19 coronavirus coronavirus NN cord-255011-7oqfod62 150 20 type type NN cord-255011-7oqfod62 150 21 I i NN cord-255011-7oqfod62 150 22 ) ) -RRB- cord-255011-7oqfod62 150 23 or or CC cord-255011-7oqfod62 150 24 type type NN cord-255011-7oqfod62 150 25 II II NNP cord-255011-7oqfod62 150 26 ( ( -LRB- cord-255011-7oqfod62 150 27 related relate VBN cord-255011-7oqfod62 150 28 to to IN cord-255011-7oqfod62 150 29 feline feline JJ cord-255011-7oqfod62 150 30 coronavirus coronavirus NN cord-255011-7oqfod62 150 31 type type NN cord-255011-7oqfod62 150 32 II II NNP cord-255011-7oqfod62 150 33 ) ) -RRB- cord-255011-7oqfod62 150 34 [ [ -LRB- cord-255011-7oqfod62 150 35 32 32 CD cord-255011-7oqfod62 150 36 ] ] -RRB- cord-255011-7oqfod62 150 37 . . . cord-255011-7oqfod62 151 1 Although although IN cord-255011-7oqfod62 151 2 CCoV CCoV NNP cord-255011-7oqfod62 151 3 has have VBZ cord-255011-7oqfod62 151 4 been be VBN cord-255011-7oqfod62 151 5 isolated isolate VBN cord-255011-7oqfod62 151 6 from from IN cord-255011-7oqfod62 151 7 the the DT cord-255011-7oqfod62 151 8 lung lung NN cord-255011-7oqfod62 151 9 after after IN cord-255011-7oqfod62 151 10 experimental experimental JJ cord-255011-7oqfod62 151 11 infections infection NNS cord-255011-7oqfod62 151 12 [ [ -LRB- cord-255011-7oqfod62 151 13 33 33 CD cord-255011-7oqfod62 151 14 ] ] -RRB- cord-255011-7oqfod62 151 15 , , , cord-255011-7oqfod62 151 16 it -PRON- PRP cord-255011-7oqfod62 151 17 was be VBD cord-255011-7oqfod62 151 18 generally generally RB cord-255011-7oqfod62 151 19 considered consider VBN cord-255011-7oqfod62 151 20 to to TO cord-255011-7oqfod62 151 21 be be VB cord-255011-7oqfod62 151 22 restricted restrict VBN cord-255011-7oqfod62 151 23 to to IN cord-255011-7oqfod62 151 24 the the DT cord-255011-7oqfod62 151 25 gastrointestinal gastrointestinal JJ cord-255011-7oqfod62 151 26 tract tract NN cord-255011-7oqfod62 151 27 during during IN cord-255011-7oqfod62 151 28 naturally naturally RB cord-255011-7oqfod62 151 29 occurring occur VBG cord-255011-7oqfod62 151 30 infection infection NN cord-255011-7oqfod62 151 31 . . . cord-255011-7oqfod62 152 1 Recently recently RB cord-255011-7oqfod62 152 2 , , , cord-255011-7oqfod62 152 3 an an DT cord-255011-7oqfod62 152 4 outbreak outbreak NN cord-255011-7oqfod62 152 5 of of IN cord-255011-7oqfod62 152 6 a a DT cord-255011-7oqfod62 152 7 systemic systemic JJ cord-255011-7oqfod62 152 8 fatal fatal JJ cord-255011-7oqfod62 152 9 disease disease NN cord-255011-7oqfod62 152 10 was be VBD cord-255011-7oqfod62 152 11 described describe VBN cord-255011-7oqfod62 152 12 from from IN cord-255011-7oqfod62 152 13 which which WDT cord-255011-7oqfod62 152 14 a a DT cord-255011-7oqfod62 152 15 type type NN cord-255011-7oqfod62 152 16 II II NNP cord-255011-7oqfod62 152 17 CCoV CCoV NNP cord-255011-7oqfod62 152 18 was be VBD cord-255011-7oqfod62 152 19 isolated isolate VBN cord-255011-7oqfod62 152 20 [ [ -LRB- cord-255011-7oqfod62 152 21 34 34 CD cord-255011-7oqfod62 152 22 ] ] -RRB- cord-255011-7oqfod62 152 23 . . . cord-255011-7oqfod62 153 1 Although although IN cord-255011-7oqfod62 153 2 the the DT cord-255011-7oqfod62 153 3 dogs dog NNS cord-255011-7oqfod62 153 4 presented present VBN cord-255011-7oqfod62 153 5 with with IN cord-255011-7oqfod62 153 6 vomiting vomiting NN cord-255011-7oqfod62 153 7 , , , cord-255011-7oqfod62 153 8 diarrhea diarrhea NN cord-255011-7oqfod62 153 9 , , , cord-255011-7oqfod62 153 10 and and CC cord-255011-7oqfod62 153 11 neurologic neurologic JJ cord-255011-7oqfod62 153 12 signs sign NNS cord-255011-7oqfod62 153 13 , , , cord-255011-7oqfod62 153 14 postmortem postmortem JJ cord-255011-7oqfod62 153 15 examination examination NN cord-255011-7oqfod62 153 16 also also RB cord-255011-7oqfod62 153 17 revealed reveal VBD cord-255011-7oqfod62 153 18 bronchopneumonia bronchopneumonia NN cord-255011-7oqfod62 153 19 . . . cord-255011-7oqfod62 154 1 CCoV CCoV NNP cord-255011-7oqfod62 154 2 was be VBD cord-255011-7oqfod62 154 3 detected detect VBN cord-255011-7oqfod62 154 4 in in IN cord-255011-7oqfod62 154 5 internal internal JJ cord-255011-7oqfod62 154 6 organs organ NNS cord-255011-7oqfod62 154 7 , , , cord-255011-7oqfod62 154 8 including include VBG cord-255011-7oqfod62 154 9 the the DT cord-255011-7oqfod62 154 10 lung lung NN cord-255011-7oqfod62 154 11 , , , cord-255011-7oqfod62 154 12 kidney kidney NN cord-255011-7oqfod62 154 13 , , , cord-255011-7oqfod62 154 14 and and CC cord-255011-7oqfod62 154 15 brain brain NN cord-255011-7oqfod62 154 16 . . . cord-255011-7oqfod62 155 1 Sequence sequence NN cord-255011-7oqfod62 155 2 analysis analysis NN cord-255011-7oqfod62 155 3 of of IN cord-255011-7oqfod62 155 4 the the DT cord-255011-7oqfod62 155 5 CCoV CCoV NNP cord-255011-7oqfod62 155 6 isolate isolate NN cord-255011-7oqfod62 155 7 identified identify VBD cord-255011-7oqfod62 155 8 a a DT cord-255011-7oqfod62 155 9 mutation mutation NN cord-255011-7oqfod62 155 10 in in IN cord-255011-7oqfod62 155 11 open open JJ cord-255011-7oqfod62 155 12 reading reading NN cord-255011-7oqfod62 155 13 frame frame NN cord-255011-7oqfod62 155 14 3b 3b CD cord-255011-7oqfod62 155 15 , , , cord-255011-7oqfod62 155 16 leading lead VBG cord-255011-7oqfod62 155 17 to to IN cord-255011-7oqfod62 155 18 a a DT cord-255011-7oqfod62 155 19 truncated truncated JJ cord-255011-7oqfod62 155 20 nonstructural nonstructural JJ cord-255011-7oqfod62 155 21 protein protein NN cord-255011-7oqfod62 155 22 . . . cord-255011-7oqfod62 156 1 It -PRON- PRP cord-255011-7oqfod62 156 2 is be VBZ cord-255011-7oqfod62 156 3 not not RB cord-255011-7oqfod62 156 4 clear clear JJ cord-255011-7oqfod62 156 5 if if IN cord-255011-7oqfod62 156 6 this this DT cord-255011-7oqfod62 156 7 mutation mutation NN cord-255011-7oqfod62 156 8 is be VBZ cord-255011-7oqfod62 156 9 responsible responsible JJ cord-255011-7oqfod62 156 10 for for IN cord-255011-7oqfod62 156 11 the the DT cord-255011-7oqfod62 156 12 extended extended JJ cord-255011-7oqfod62 156 13 tropism tropism NN cord-255011-7oqfod62 156 14 of of IN cord-255011-7oqfod62 156 15 this this DT cord-255011-7oqfod62 156 16 isolate isolate NN cord-255011-7oqfod62 156 17 [ [ -LRB- cord-255011-7oqfod62 156 18 35 35 CD cord-255011-7oqfod62 156 19 ] ] -RRB- cord-255011-7oqfod62 156 20 . . . cord-255011-7oqfod62 157 1 Further further JJ cord-255011-7oqfod62 157 2 studies study NNS cord-255011-7oqfod62 157 3 are be VBP cord-255011-7oqfod62 157 4 required require VBN cord-255011-7oqfod62 157 5 to to TO cord-255011-7oqfod62 157 6 determine determine VB cord-255011-7oqfod62 157 7 the the DT cord-255011-7oqfod62 157 8 presence presence NN cord-255011-7oqfod62 157 9 of of IN cord-255011-7oqfod62 157 10 type type NN cord-255011-7oqfod62 157 11 II II NNP cord-255011-7oqfod62 157 12 CCoVs ccovs NN cord-255011-7oqfod62 157 13 in in IN cord-255011-7oqfod62 157 14 cases case NNS cord-255011-7oqfod62 157 15 of of IN cord-255011-7oqfod62 157 16 severe severe JJ cord-255011-7oqfod62 157 17 systemic systemic JJ cord-255011-7oqfod62 157 18 disease disease NN cord-255011-7oqfod62 157 19 and and CC cord-255011-7oqfod62 157 20 in in IN cord-255011-7oqfod62 157 21 cases case NNS cord-255011-7oqfod62 157 22 of of IN cord-255011-7oqfod62 157 23 respiratory respiratory JJ cord-255011-7oqfod62 157 24 disease disease NN cord-255011-7oqfod62 157 25 . . . cord-255011-7oqfod62 158 1 CRCoV CRCoV NNP cord-255011-7oqfod62 158 2 is be VBZ cord-255011-7oqfod62 158 3 a a DT cord-255011-7oqfod62 158 4 novel novel JJ cord-255011-7oqfod62 158 5 coronavirus coronavirus NN cord-255011-7oqfod62 158 6 of of IN cord-255011-7oqfod62 158 7 dogs dog NNS cord-255011-7oqfod62 158 8 distinct distinct JJ cord-255011-7oqfod62 158 9 from from IN cord-255011-7oqfod62 158 10 CCoV. ccov. NN cord-255011-7oqfod62 159 1 It -PRON- PRP cord-255011-7oqfod62 159 2 is be VBZ cord-255011-7oqfod62 159 3 present present JJ cord-255011-7oqfod62 159 4 in in IN cord-255011-7oqfod62 159 5 North North NNP cord-255011-7oqfod62 159 6 America America NNP cord-255011-7oqfod62 159 7 , , , cord-255011-7oqfod62 159 8 Europe Europe NNP cord-255011-7oqfod62 159 9 , , , cord-255011-7oqfod62 159 10 and and CC cord-255011-7oqfod62 159 11 Japan Japan NNP cord-255011-7oqfod62 159 12 . . . cord-255011-7oqfod62 160 1 CRCoV CRCoV NNP cord-255011-7oqfod62 160 2 is be VBZ cord-255011-7oqfod62 160 3 frequently frequently RB cord-255011-7oqfod62 160 4 detected detect VBN cord-255011-7oqfod62 160 5 in in IN cord-255011-7oqfod62 160 6 dogs dog NNS cord-255011-7oqfod62 160 7 with with IN cord-255011-7oqfod62 160 8 clinical clinical JJ cord-255011-7oqfod62 160 9 respiratory respiratory JJ cord-255011-7oqfod62 160 10 signs sign NNS cord-255011-7oqfod62 160 11 and and CC cord-255011-7oqfod62 160 12 may may MD cord-255011-7oqfod62 160 13 contribute contribute VB cord-255011-7oqfod62 160 14 to to IN cord-255011-7oqfod62 160 15 the the DT cord-255011-7oqfod62 160 16 CIRD CIRD NNP cord-255011-7oqfod62 160 17 complex complex JJ cord-255011-7oqfod62 160 18 . . . cord-255011-7oqfod62 161 1 Increased increase VBN cord-255011-7oqfod62 161 2 awareness awareness NN cord-255011-7oqfod62 161 3 of of IN cord-255011-7oqfod62 161 4 the the DT cord-255011-7oqfod62 161 5 existence existence NN cord-255011-7oqfod62 161 6 of of IN cord-255011-7oqfod62 161 7 CRCoV crcov NN cord-255011-7oqfod62 161 8 and and CC cord-255011-7oqfod62 161 9 the the DT cord-255011-7oqfod62 161 10 development development NN cord-255011-7oqfod62 161 11 of of IN cord-255011-7oqfod62 161 12 routinely routinely RB cord-255011-7oqfod62 161 13 available available JJ cord-255011-7oqfod62 161 14 diagnostic diagnostic JJ cord-255011-7oqfod62 161 15 tests test NNS cord-255011-7oqfod62 161 16 should should MD cord-255011-7oqfod62 161 17 enhance enhance VB cord-255011-7oqfod62 161 18 our -PRON- PRP$ cord-255011-7oqfod62 161 19 knowledge knowledge NN cord-255011-7oqfod62 161 20 of of IN cord-255011-7oqfod62 161 21 the the DT cord-255011-7oqfod62 161 22 presence presence NN cord-255011-7oqfod62 161 23 of of IN cord-255011-7oqfod62 161 24 CRCoV crcov NN cord-255011-7oqfod62 161 25 in in IN cord-255011-7oqfod62 161 26 canine canine JJ cord-255011-7oqfod62 161 27 populations population NNS cord-255011-7oqfod62 161 28 with with IN cord-255011-7oqfod62 161 29 and and CC cord-255011-7oqfod62 161 30 without without IN cord-255011-7oqfod62 161 31 respiratory respiratory JJ cord-255011-7oqfod62 161 32 disease disease NN cord-255011-7oqfod62 161 33 . . . cord-255011-7oqfod62 162 1 It -PRON- PRP cord-255011-7oqfod62 162 2 is be VBZ cord-255011-7oqfod62 162 3 recommended recommend VBN cord-255011-7oqfod62 162 4 to to TO cord-255011-7oqfod62 162 5 use use VB cord-255011-7oqfod62 162 6 PCR PCR NNP cord-255011-7oqfod62 162 7 methods method NNS cord-255011-7oqfod62 162 8 or or CC cord-255011-7oqfod62 162 9 serology serology NN cord-255011-7oqfod62 162 10 on on IN cord-255011-7oqfod62 162 11 paired paired JJ cord-255011-7oqfod62 162 12 serum serum NN cord-255011-7oqfod62 162 13 samples sample NNS cord-255011-7oqfod62 162 14 to to TO cord-255011-7oqfod62 162 15 diagnose diagnose VB cord-255011-7oqfod62 162 16 CRCoV crcov NN cord-255011-7oqfod62 162 17 infections infection NNS cord-255011-7oqfod62 162 18 , , , cord-255011-7oqfod62 162 19 because because IN cord-255011-7oqfod62 162 20 the the DT cord-255011-7oqfod62 162 21 sensitivity sensitivity NN cord-255011-7oqfod62 162 22 of of IN cord-255011-7oqfod62 162 23 virus virus NN cord-255011-7oqfod62 162 24 isolation isolation NN cord-255011-7oqfod62 162 25 is be VBZ cord-255011-7oqfod62 162 26 low low JJ cord-255011-7oqfod62 162 27 . . . cord-255011-7oqfod62 163 1 Identification identification NN cord-255011-7oqfod62 163 2 of of IN cord-255011-7oqfod62 163 3 causative causative JJ cord-255011-7oqfod62 163 4 agents agent NNS cord-255011-7oqfod62 163 5 during during IN cord-255011-7oqfod62 163 6 outbreaks outbreak NNS cord-255011-7oqfod62 163 7 of of IN cord-255011-7oqfod62 163 8 respiratory respiratory JJ cord-255011-7oqfod62 163 9 disease disease NN cord-255011-7oqfod62 163 10 in in IN cord-255011-7oqfod62 163 11 canine canine JJ cord-255011-7oqfod62 163 12 populations population NNS cord-255011-7oqfod62 163 13 ought ought MD cord-255011-7oqfod62 163 14 to to TO cord-255011-7oqfod62 163 15 be be VB cord-255011-7oqfod62 163 16 performed perform VBN cord-255011-7oqfod62 163 17 more more RBR cord-255011-7oqfod62 163 18 frequently frequently RB cord-255011-7oqfod62 163 19 . . . cord-255011-7oqfod62 164 1 This this DT cord-255011-7oqfod62 164 2 would would MD cord-255011-7oqfod62 164 3 help help VB cord-255011-7oqfod62 164 4 to to TO cord-255011-7oqfod62 164 5 determine determine VB cord-255011-7oqfod62 164 6 the the DT cord-255011-7oqfod62 164 7 importance importance NN cord-255011-7oqfod62 164 8 of of IN cord-255011-7oqfod62 164 9 individual individual JJ cord-255011-7oqfod62 164 10 viruses virus NNS cord-255011-7oqfod62 164 11 and and CC cord-255011-7oqfod62 164 12 bacteria bacteria NNS cord-255011-7oqfod62 164 13 , , , cord-255011-7oqfod62 164 14 not not RB cord-255011-7oqfod62 164 15 only only RB cord-255011-7oqfod62 164 16 in in IN cord-255011-7oqfod62 164 17 the the DT cord-255011-7oqfod62 164 18 investigated investigate VBN cord-255011-7oqfod62 164 19 population population NN cord-255011-7oqfod62 164 20 but but CC cord-255011-7oqfod62 164 21 in in IN cord-255011-7oqfod62 164 22 the the DT cord-255011-7oqfod62 164 23 CIRD CIRD NNP cord-255011-7oqfod62 164 24 complex complex JJ cord-255011-7oqfod62 164 25 as as IN cord-255011-7oqfod62 164 26 a a DT cord-255011-7oqfod62 164 27 whole whole NN cord-255011-7oqfod62 164 28 . . . cord-255011-7oqfod62 165 1 The the DT cord-255011-7oqfod62 165 2 etiology etiology NN cord-255011-7oqfod62 165 3 of of IN cord-255011-7oqfod62 165 4 CIRD CIRD NNP cord-255011-7oqfod62 165 5 is be VBZ cord-255011-7oqfod62 165 6 multifactorial multifactorial JJ cord-255011-7oqfod62 165 7 and and CC cord-255011-7oqfod62 165 8 is be VBZ cord-255011-7oqfod62 165 9 likely likely JJ cord-255011-7oqfod62 165 10 to to TO cord-255011-7oqfod62 165 11 change change VB cord-255011-7oqfod62 165 12 continuously continuously RB cord-255011-7oqfod62 165 13 , , , cord-255011-7oqfod62 165 14 because because IN cord-255011-7oqfod62 165 15 some some DT cord-255011-7oqfod62 165 16 pathogens pathogen NNS cord-255011-7oqfod62 165 17 are be VBP cord-255011-7oqfod62 165 18 controlled control VBN cord-255011-7oqfod62 165 19 by by IN cord-255011-7oqfod62 165 20 vaccination vaccination NN cord-255011-7oqfod62 165 21 , , , cord-255011-7oqfod62 165 22 although although IN cord-255011-7oqfod62 165 23 other other JJ cord-255011-7oqfod62 165 24 infectious infectious JJ cord-255011-7oqfod62 165 25 agents agent NNS cord-255011-7oqfod62 165 26 emerge emerge VBP cord-255011-7oqfod62 165 27 to to TO cord-255011-7oqfod62 165 28 take take VB cord-255011-7oqfod62 165 29 their -PRON- PRP$ cord-255011-7oqfod62 165 30 place place NN cord-255011-7oqfod62 165 31 . . . cord-255011-7oqfod62 166 1 Canine canine JJ cord-255011-7oqfod62 166 2 distemper distemper NN cord-255011-7oqfod62 166 3 : : : cord-255011-7oqfod62 167 1 re re NN cord-255011-7oqfod62 167 2 - - NN cord-255011-7oqfod62 167 3 emergence emergence NN cord-255011-7oqfod62 168 1 of of IN cord-255011-7oqfod62 168 2 an an DT cord-255011-7oqfod62 168 3 old old JJ cord-255011-7oqfod62 168 4 enemy enemy NN cord-255011-7oqfod62 168 5 SV-5-like sv-5-like IN cord-255011-7oqfod62 168 6 parainfluenza parainfluenza NNP cord-255011-7oqfod62 168 7 virus virus NN cord-255011-7oqfod62 168 8 in in IN cord-255011-7oqfod62 168 9 dogs dogs NNP cord-255011-7oqfod62 168 10 Association Association NNP cord-255011-7oqfod62 168 11 of of IN cord-255011-7oqfod62 168 12 canine canine JJ cord-255011-7oqfod62 168 13 adenovirus adenovirus NN cord-255011-7oqfod62 168 14 ( ( -LRB- cord-255011-7oqfod62 168 15 Toronto Toronto NNP cord-255011-7oqfod62 168 16 A a DT cord-255011-7oqfod62 168 17 26/ 26/ CD cord-255011-7oqfod62 168 18 61 61 CD cord-255011-7oqfod62 168 19 ) ) -RRB- cord-255011-7oqfod62 168 20 with with IN cord-255011-7oqfod62 168 21 an an DT cord-255011-7oqfod62 168 22 outbreak outbreak NN cord-255011-7oqfod62 168 23 of of IN cord-255011-7oqfod62 168 24 laryngotracheitis laryngotracheitis NNP cord-255011-7oqfod62 168 25 ( ( -LRB- cord-255011-7oqfod62 168 26 ' ' '' cord-255011-7oqfod62 168 27 ' ' '' cord-255011-7oqfod62 168 28 kennel kennel NN cord-255011-7oqfod62 168 29 cough cough NN cord-255011-7oqfod62 168 30 ' ' '' cord-255011-7oqfod62 168 31 ' ' '' cord-255011-7oqfod62 168 32 ) ) -RRB- cord-255011-7oqfod62 169 1 : : : cord-255011-7oqfod62 169 2 a a DT cord-255011-7oqfod62 169 3 preliminary preliminary JJ cord-255011-7oqfod62 169 4 report report NN cord-255011-7oqfod62 169 5 Canine canine JJ cord-255011-7oqfod62 169 6 tracheobronchitis tracheobronchitis NN cord-255011-7oqfod62 169 7 : : : cord-255011-7oqfod62 169 8 isolation isolation NN cord-255011-7oqfod62 169 9 and and CC cord-255011-7oqfod62 169 10 characterization characterization NN cord-255011-7oqfod62 169 11 of of IN cord-255011-7oqfod62 169 12 the the DT cord-255011-7oqfod62 169 13 agent agent NN cord-255011-7oqfod62 169 14 with with IN cord-255011-7oqfod62 169 15 experimental experimental JJ cord-255011-7oqfod62 169 16 reproduction reproduction NN cord-255011-7oqfod62 169 17 of of IN cord-255011-7oqfod62 169 18 the the DT cord-255011-7oqfod62 169 19 disease disease NN cord-255011-7oqfod62 169 20 Transmission Transmission NNP cord-255011-7oqfod62 169 21 of of IN cord-255011-7oqfod62 169 22 equine equine JJ cord-255011-7oqfod62 169 23 influenza influenza NN cord-255011-7oqfod62 169 24 virus virus NN cord-255011-7oqfod62 169 25 to to IN cord-255011-7oqfod62 169 26 dogs dog NNS cord-255011-7oqfod62 169 27 Bordetella Bordetella NNP cord-255011-7oqfod62 169 28 and and CC cord-255011-7oqfod62 169 29 mycoplasma mycoplasma NN cord-255011-7oqfod62 169 30 respiratory respiratory JJ cord-255011-7oqfod62 169 31 infections infection NNS cord-255011-7oqfod62 169 32 in in IN cord-255011-7oqfod62 169 33 dogs dog NNS cord-255011-7oqfod62 169 34 and and CC cord-255011-7oqfod62 169 35 cats cat NNS cord-255011-7oqfod62 169 36 Mycoplasmas Mycoplasmas NNP cord-255011-7oqfod62 169 37 associated associate VBN cord-255011-7oqfod62 169 38 with with IN cord-255011-7oqfod62 169 39 canine canine JJ cord-255011-7oqfod62 169 40 infectious infectious JJ cord-255011-7oqfod62 169 41 respiratory respiratory JJ cord-255011-7oqfod62 169 42 disease disease NN cord-255011-7oqfod62 170 1 The the DT cord-255011-7oqfod62 170 2 association association NN cord-255011-7oqfod62 170 3 of of IN cord-255011-7oqfod62 170 4 streptococcus streptococcus NNP cord-255011-7oqfod62 170 5 equi equi NNP cord-255011-7oqfod62 170 6 subsp subsp NN cord-255011-7oqfod62 170 7 . . . cord-255011-7oqfod62 171 1 zooepidemicus zooepidemicus NNP cord-255011-7oqfod62 171 2 with with IN cord-255011-7oqfod62 171 3 canine canine JJ cord-255011-7oqfod62 171 4 infectious infectious JJ cord-255011-7oqfod62 171 5 respiratory respiratory JJ cord-255011-7oqfod62 171 6 disease disease NN cord-255011-7oqfod62 171 7 Detection detection NN cord-255011-7oqfod62 171 8 of of IN cord-255011-7oqfod62 171 9 a a DT cord-255011-7oqfod62 171 10 group group NN cord-255011-7oqfod62 171 11 2 2 CD cord-255011-7oqfod62 171 12 coronavirus coronavirus NN cord-255011-7oqfod62 171 13 in in IN cord-255011-7oqfod62 171 14 dogs dog NNS cord-255011-7oqfod62 171 15 with with IN cord-255011-7oqfod62 171 16 canine canine JJ cord-255011-7oqfod62 171 17 infectious infectious JJ cord-255011-7oqfod62 171 18 respiratory respiratory JJ cord-255011-7oqfod62 171 19 disease disease NN cord-255011-7oqfod62 171 20 Studies Studies NNPS cord-255011-7oqfod62 171 21 on on IN cord-255011-7oqfod62 171 22 the the DT cord-255011-7oqfod62 171 23 epizootiology epizootiology NN cord-255011-7oqfod62 171 24 of of IN cord-255011-7oqfod62 171 25 canine canine JJ cord-255011-7oqfod62 171 26 coronavirus coronavirus NN cord-255011-7oqfod62 171 27 Coronavirus Coronavirus NNP cord-255011-7oqfod62 171 28 pathogenesis pathogenesis NN cord-255011-7oqfod62 171 29 and and CC cord-255011-7oqfod62 171 30 the the DT cord-255011-7oqfod62 171 31 emerging emerge VBG cord-255011-7oqfod62 171 32 pathogen pathogen NN cord-255011-7oqfod62 171 33 severe severe JJ cord-255011-7oqfod62 171 34 acute acute JJ cord-255011-7oqfod62 171 35 respiratory respiratory JJ cord-255011-7oqfod62 171 36 syndrome syndrome NN cord-255011-7oqfod62 171 37 coronavirus coronavirus NN cord-255011-7oqfod62 171 38 Detection detection NN cord-255011-7oqfod62 171 39 of of IN cord-255011-7oqfod62 171 40 coronavirus coronavirus NN cord-255011-7oqfod62 171 41 in in IN cord-255011-7oqfod62 171 42 cases case NNS cord-255011-7oqfod62 171 43 of of IN cord-255011-7oqfod62 171 44 tracheobronchitis tracheobronchitis NN cord-255011-7oqfod62 171 45 in in IN cord-255011-7oqfod62 171 46 dogs dog NNS cord-255011-7oqfod62 171 47 : : : cord-255011-7oqfod62 172 1 a a DT cord-255011-7oqfod62 172 2 retrospective retrospective JJ cord-255011-7oqfod62 172 3 study study NN cord-255011-7oqfod62 172 4 from from IN cord-255011-7oqfod62 172 5 1971 1971 CD cord-255011-7oqfod62 172 6 to to IN cord-255011-7oqfod62 172 7 2003 2003 CD cord-255011-7oqfod62 172 8 Isolation isolation NN cord-255011-7oqfod62 172 9 and and CC cord-255011-7oqfod62 172 10 sequence sequence NN cord-255011-7oqfod62 172 11 analysis analysis NN cord-255011-7oqfod62 172 12 of of IN cord-255011-7oqfod62 172 13 canine canine JJ cord-255011-7oqfod62 172 14 respiratory respiratory JJ cord-255011-7oqfod62 172 15 coronavirus coronavirus NN cord-255011-7oqfod62 172 16 Complete complete VB cord-255011-7oqfod62 172 17 genomic genomic JJ cord-255011-7oqfod62 172 18 sequence sequence NN cord-255011-7oqfod62 172 19 of of IN cord-255011-7oqfod62 172 20 human human JJ cord-255011-7oqfod62 172 21 coronavirus coronavirus NN cord-255011-7oqfod62 172 22 OC43 OC43 NNP cord-255011-7oqfod62 172 23 : : : cord-255011-7oqfod62 172 24 molecular molecular JJ cord-255011-7oqfod62 172 25 clock clock NN cord-255011-7oqfod62 172 26 analysis analysis NN cord-255011-7oqfod62 172 27 suggests suggest VBZ cord-255011-7oqfod62 172 28 a a DT cord-255011-7oqfod62 172 29 relatively relatively RB cord-255011-7oqfod62 172 30 recent recent JJ cord-255011-7oqfod62 172 31 zoonotic zoonotic JJ cord-255011-7oqfod62 172 32 coronavirus coronavirus NN cord-255011-7oqfod62 172 33 transmission transmission NN cord-255011-7oqfod62 172 34 event event NN cord-255011-7oqfod62 172 35 Coronavirus Coronavirus NNP cord-255011-7oqfod62 172 36 as as IN cord-255011-7oqfod62 172 37 a a DT cord-255011-7oqfod62 172 38 possible possible JJ cord-255011-7oqfod62 172 39 cause cause NN cord-255011-7oqfod62 172 40 of of IN cord-255011-7oqfod62 172 41 severe severe JJ cord-255011-7oqfod62 172 42 acute acute JJ cord-255011-7oqfod62 172 43 respiratory respiratory JJ cord-255011-7oqfod62 172 44 syndrome syndrome NN cord-255011-7oqfod62 172 45 Viruses virus NNS cord-255011-7oqfod62 172 46 and and CC cord-255011-7oqfod62 172 47 bacteria bacteria NNS cord-255011-7oqfod62 172 48 in in IN cord-255011-7oqfod62 172 49 the the DT cord-255011-7oqfod62 172 50 etiology etiology NN cord-255011-7oqfod62 172 51 of of IN cord-255011-7oqfod62 172 52 the the DT cord-255011-7oqfod62 172 53 common common JJ cord-255011-7oqfod62 172 54 cold cold JJ cord-255011-7oqfod62 172 55 Identification identification NN cord-255011-7oqfod62 172 56 of of IN cord-255011-7oqfod62 172 57 a a DT cord-255011-7oqfod62 172 58 new new JJ cord-255011-7oqfod62 172 59 human human JJ cord-255011-7oqfod62 172 60 coronavirus coronavirus NN cord-255011-7oqfod62 172 61 Characterization characterization NN cord-255011-7oqfod62 172 62 and and CC cord-255011-7oqfod62 172 63 complete complete JJ cord-255011-7oqfod62 172 64 genome genome NN cord-255011-7oqfod62 172 65 sequence sequence NN cord-255011-7oqfod62 172 66 of of IN cord-255011-7oqfod62 172 67 a a DT cord-255011-7oqfod62 172 68 novel novel JJ cord-255011-7oqfod62 172 69 coronavirus coronavirus NN cord-255011-7oqfod62 172 70 , , , cord-255011-7oqfod62 172 71 coronavirus coronavirus NN cord-255011-7oqfod62 172 72 HKU1 HKU1 NNP cord-255011-7oqfod62 172 73 , , , cord-255011-7oqfod62 172 74 from from IN cord-255011-7oqfod62 172 75 patients patient NNS cord-255011-7oqfod62 172 76 with with IN cord-255011-7oqfod62 172 77 pneumonia pneumonia NN cord-255011-7oqfod62 172 78 Coronavirus Coronavirus NNP cord-255011-7oqfod62 172 79 avian avian JJ cord-255011-7oqfod62 172 80 infectious infectious JJ cord-255011-7oqfod62 172 81 bronchitis bronchitis NN cord-255011-7oqfod62 172 82 virus virus NN cord-255011-7oqfod62 172 83 Coronavirus Coronavirus NNP cord-255011-7oqfod62 172 84 and and CC cord-255011-7oqfod62 172 85 Pasteurella Pasteurella NNP cord-255011-7oqfod62 172 86 infections infection NNS cord-255011-7oqfod62 172 87 in in IN cord-255011-7oqfod62 172 88 bovine bovine JJ cord-255011-7oqfod62 172 89 shipping shipping NN cord-255011-7oqfod62 172 90 fever fever NN cord-255011-7oqfod62 172 91 pneumonia pneumonia NN cord-255011-7oqfod62 172 92 and and CC cord-255011-7oqfod62 172 93 Evans Evans NNP cord-255011-7oqfod62 172 94 ' ' POS cord-255011-7oqfod62 172 95 criteria criterion NNS cord-255011-7oqfod62 172 96 for for IN cord-255011-7oqfod62 172 97 causation causation NN cord-255011-7oqfod62 172 98 Investigation Investigation NNP cord-255011-7oqfod62 172 99 into into IN cord-255011-7oqfod62 172 100 the the DT cord-255011-7oqfod62 172 101 causes cause NNS cord-255011-7oqfod62 172 102 of of IN cord-255011-7oqfod62 172 103 canine canine JJ cord-255011-7oqfod62 172 104 infectious infectious JJ cord-255011-7oqfod62 172 105 respiratory respiratory JJ cord-255011-7oqfod62 172 106 disease disease NN cord-255011-7oqfod62 172 107 : : : cord-255011-7oqfod62 172 108 antibody antibody NN cord-255011-7oqfod62 172 109 responses response NNS cord-255011-7oqfod62 172 110 to to IN cord-255011-7oqfod62 172 111 canine canine JJ cord-255011-7oqfod62 172 112 respiratory respiratory JJ cord-255011-7oqfod62 172 113 coronavirus coronavirus NN cord-255011-7oqfod62 172 114 and and CC cord-255011-7oqfod62 172 115 canine canine JJ cord-255011-7oqfod62 172 116 herpesvirus herpesvirus NN cord-255011-7oqfod62 172 117 in in IN cord-255011-7oqfod62 172 118 two two CD cord-255011-7oqfod62 172 119 kennelled kennel VBN cord-255011-7oqfod62 172 120 dog dog NN cord-255011-7oqfod62 172 121 populations population NNS cord-255011-7oqfod62 172 122 Survey Survey NNP cord-255011-7oqfod62 172 123 of of IN cord-255011-7oqfod62 172 124 dogs dog NNS cord-255011-7oqfod62 172 125 in in IN cord-255011-7oqfod62 172 126 Japan Japan NNP cord-255011-7oqfod62 172 127 for for IN cord-255011-7oqfod62 172 128 group group NN cord-255011-7oqfod62 172 129 2 2 CD cord-255011-7oqfod62 172 130 canine canine JJ cord-255011-7oqfod62 172 131 coronavirus coronavirus NN cord-255011-7oqfod62 172 132 infection infection NN cord-255011-7oqfod62 173 1 The the DT cord-255011-7oqfod62 173 2 prevalence prevalence NN cord-255011-7oqfod62 173 3 of of IN cord-255011-7oqfod62 173 4 a a DT cord-255011-7oqfod62 173 5 group group NN cord-255011-7oqfod62 173 6 2 2 CD cord-255011-7oqfod62 173 7 coronavirus coronavirus NN cord-255011-7oqfod62 173 8 in in IN cord-255011-7oqfod62 173 9 dogs dog NNS cord-255011-7oqfod62 173 10 in in IN cord-255011-7oqfod62 173 11 Japan Japan NNP cord-255011-7oqfod62 173 12 Serological serological JJ cord-255011-7oqfod62 173 13 prevalence prevalence NN cord-255011-7oqfod62 173 14 of of IN cord-255011-7oqfod62 173 15 canine canine JJ cord-255011-7oqfod62 173 16 respiratory respiratory JJ cord-255011-7oqfod62 173 17 coronavirus coronavirus NN cord-255011-7oqfod62 174 1 Serological serological JJ cord-255011-7oqfod62 174 2 prevalence prevalence NN cord-255011-7oqfod62 174 3 of of IN cord-255011-7oqfod62 174 4 canine canine JJ cord-255011-7oqfod62 174 5 respiratory respiratory JJ cord-255011-7oqfod62 174 6 coronavirus coronavirus NN cord-255011-7oqfod62 174 7 in in IN cord-255011-7oqfod62 174 8 southern southern JJ cord-255011-7oqfod62 174 9 Italy Italy NNP cord-255011-7oqfod62 174 10 and and CC cord-255011-7oqfod62 174 11 epidemiological epidemiological JJ cord-255011-7oqfod62 174 12 relationship relationship NN cord-255011-7oqfod62 174 13 with with IN cord-255011-7oqfod62 174 14 canine canine JJ cord-255011-7oqfod62 174 15 enteric enteric JJ cord-255011-7oqfod62 174 16 coronavirus coronavirus NN cord-255011-7oqfod62 174 17 Serological serological JJ cord-255011-7oqfod62 174 18 and and CC cord-255011-7oqfod62 174 19 molecular molecular JJ cord-255011-7oqfod62 174 20 evidence evidence NN cord-255011-7oqfod62 174 21 that that IN cord-255011-7oqfod62 174 22 canine canine JJ cord-255011-7oqfod62 174 23 respiratory respiratory JJ cord-255011-7oqfod62 174 24 coronavirus coronavirus NN cord-255011-7oqfod62 174 25 is be VBZ cord-255011-7oqfod62 174 26 circulating circulate VBG cord-255011-7oqfod62 174 27 in in IN cord-255011-7oqfod62 175 1 Italy Italy NNP cord-255011-7oqfod62 175 2 Epidemiology Epidemiology NNP cord-255011-7oqfod62 175 3 of of IN cord-255011-7oqfod62 175 4 coronavirus coronavirus NN cord-255011-7oqfod62 175 5 respiratory respiratory JJ cord-255011-7oqfod62 175 6 infections infection NNS cord-255011-7oqfod62 175 7 Longitudinal longitudinal JJ cord-255011-7oqfod62 175 8 study study NN cord-255011-7oqfod62 175 9 of of IN cord-255011-7oqfod62 175 10 viruses virus NNS cord-255011-7oqfod62 175 11 associated associate VBN cord-255011-7oqfod62 175 12 with with IN cord-255011-7oqfod62 175 13 canine canine JJ cord-255011-7oqfod62 175 14 infectious infectious JJ cord-255011-7oqfod62 175 15 respiratory respiratory JJ cord-255011-7oqfod62 175 16 disease disease NN cord-255011-7oqfod62 176 1 The the DT cord-255011-7oqfod62 176 2 infectivity infectivity NN cord-255011-7oqfod62 176 3 and and CC cord-255011-7oqfod62 176 4 pathogenicity pathogenicity NN cord-255011-7oqfod62 176 5 of of IN cord-255011-7oqfod62 176 6 a a DT cord-255011-7oqfod62 176 7 group group NN cord-255011-7oqfod62 176 8 2 2 CD cord-255011-7oqfod62 176 9 bovine bovine JJ cord-255011-7oqfod62 176 10 coronavirus coronavirus NN cord-255011-7oqfod62 176 11 in in IN cord-255011-7oqfod62 176 12 pups pup NNS cord-255011-7oqfod62 176 13 Respiratory respiratory JJ cord-255011-7oqfod62 176 14 disease disease NN cord-255011-7oqfod62 176 15 in in IN cord-255011-7oqfod62 176 16 kennelled kennel VBN cord-255011-7oqfod62 176 17 dogs dog NNS cord-255011-7oqfod62 176 18 : : : cord-255011-7oqfod62 176 19 serological serological JJ cord-255011-7oqfod62 176 20 responses response NNS cord-255011-7oqfod62 176 21 to to IN cord-255011-7oqfod62 176 22 bordetella bordetella NNP cord-255011-7oqfod62 176 23 bronchiseptica bronchiseptica NNP cord-255011-7oqfod62 176 24 lipopolysaccharide lipopolysaccharide NNP cord-255011-7oqfod62 176 25 do do VBP cord-255011-7oqfod62 176 26 not not RB cord-255011-7oqfod62 176 27 correlate correlate VB cord-255011-7oqfod62 176 28 with with IN cord-255011-7oqfod62 176 29 bacterial bacterial JJ cord-255011-7oqfod62 176 30 isolation isolation NN cord-255011-7oqfod62 176 31 or or CC cord-255011-7oqfod62 176 32 clinical clinical JJ cord-255011-7oqfod62 176 33 respiratory respiratory JJ cord-255011-7oqfod62 176 34 symptoms symptom NNS cord-255011-7oqfod62 176 35 Survival survival NN cord-255011-7oqfod62 176 36 of of IN cord-255011-7oqfod62 176 37 severe severe JJ cord-255011-7oqfod62 176 38 acute acute JJ cord-255011-7oqfod62 176 39 respiratory respiratory JJ cord-255011-7oqfod62 176 40 syndrome syndrome NN cord-255011-7oqfod62 176 41 coronavirus coronavirus NN cord-255011-7oqfod62 176 42 Genetic genetic JJ cord-255011-7oqfod62 176 43 diversity diversity NN cord-255011-7oqfod62 176 44 of of IN cord-255011-7oqfod62 176 45 a a DT cord-255011-7oqfod62 176 46 canine canine JJ cord-255011-7oqfod62 176 47 coronavirus coronavirus NN cord-255011-7oqfod62 176 48 detected detect VBN cord-255011-7oqfod62 176 49 in in IN cord-255011-7oqfod62 176 50 pups pup NNS cord-255011-7oqfod62 176 51 with with IN cord-255011-7oqfod62 176 52 diarrhoea diarrhoea NN cord-255011-7oqfod62 176 53 in in IN cord-255011-7oqfod62 176 54 Italy Italy NNP cord-255011-7oqfod62 176 55 Canine canine JJ cord-255011-7oqfod62 176 56 coronavirus coronavirus NN cord-255011-7oqfod62 176 57 infection infection NN cord-255011-7oqfod62 176 58 in in IN cord-255011-7oqfod62 176 59 the the DT cord-255011-7oqfod62 176 60 dog dog NN cord-255011-7oqfod62 176 61 following follow VBG cord-255011-7oqfod62 176 62 oronasal oronasal NN cord-255011-7oqfod62 176 63 inoculation inoculation NN cord-255011-7oqfod62 176 64 Canine canine JJ cord-255011-7oqfod62 176 65 coronavirus coronavirus NN cord-255011-7oqfod62 176 66 highly highly RB cord-255011-7oqfod62 176 67 pathogenic pathogenic JJ cord-255011-7oqfod62 176 68 for for IN cord-255011-7oqfod62 176 69 dogs dog NNS cord-255011-7oqfod62 176 70 Molecular molecular JJ cord-255011-7oqfod62 176 71 characterisation characterisation NN cord-255011-7oqfod62 176 72 of of IN cord-255011-7oqfod62 176 73 the the DT cord-255011-7oqfod62 176 74 virulent virulent JJ cord-255011-7oqfod62 176 75 canine canine JJ cord-255011-7oqfod62 176 76 coronavirus coronavirus NN cord-255011-7oqfod62 176 77 CB/05 CB/05 NNP cord-255011-7oqfod62 176 78 strain strain VB