id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001072-pjv3wy80	Hong, Xiaoyun	Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine	2013-09-04		.txt	text/plain	4118	196	41	Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. 13, 14 Microneedles are mostly applied for the transdermal delivery of drugs and vaccines that may require long exposure, among which the dissolving and biodegradable microneedle technologies are most commonly seen. Microneedle technologies for sustained drug delivery has long been recognized as a highly immune reactive tissue containing an abundance of antigen-presenting cells and immunocompetent cells, especially within the epidermal and dermal skin layers. 36 DeMuth et al 37 reported an approach for rapid implantation of vaccine-loaded polymer films carrying DNA, immune-stimulatory RNA, and biodegradable polycations using microneedles coated with releasable polyelectrolyte multilayers that promoted local transfection and controlled the persistence of DNA and adjuvants in the skin from days to weeks, with kinetics determined by the film composition. 29, 35 Altogether, dissolving and biodegradable microneedle technologies have a bright future for transdermal sustained delivery of drug and vaccine, and require further studies.	./cache/cord-001072-pjv3wy80.txt	./txt/cord-001072-pjv3wy80.txt