id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299225-exbdg3x9	Guarnieri, Michael	A Long-Term Study of a Lipid-Buprenorphine Implant in Rats	2018-07-09		.txt	text/plain	2662	159	50	These results confirm the safety of cholesterol-triglyceride carrier systems for subcutaneous drug delivery in laboratory animals and suggest that this model may be used to study long-term effects of opiate therapy. We examined the safety of cholesterol-triglyceride suspensions of buprenorphine in mice and rats using US Food and Drug Administration (FDA) Target Animal Safety (TAS) drug-development protocols. Histopathology examinations were performed on mice and rats treated with up to tenfold excess of the intended dose of drug and control animals following 4-and 12-day drug trials [19] [20] [21] . The label dose of 0.65 mg/kg of buprenorphine, which provides 2-3 days of clinically significant blood levels of drug, was established in bioequivalence trials and efficacy studies using male and female rats [21] . The objective of this study was to evaluate the long-term safety of a lipid suspension of buprenorphine for delivery of an opiate analgesic in female F344 rats.	./cache/cord-299225-exbdg3x9.txt	./txt/cord-299225-exbdg3x9.txt