id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299400-j18pj11d	Norinder, Ulf	Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19	2020-07-30		.txt	text/plain	5310	251	42	We propose that the antiviral activity of (hydroxy)chloroquine and azithromycin is shared among all strong lysosomotropic drugs and is a consequence of their extremely high accumulation in cells and membranes, and subsequently of all the processes affected by this pharmacokinetic property. Among listed drugs with antiviral effects, the CADs include: psychoactive drugs (chlorpromazine, fluoxetine, clomipramine); antiarrhythmics (amiodarone); antimalarials (chloroquine, hydroxychloroquine, amodiaquine, mefloquine, quinacrine); channel blockers (amiodarone, verapamil, manidipine); antibacterial (azithromycin); estrogen receptor modulators (tamoxifen, raloxifene, toremifene); two antivirals, the only ones known to utilize CADs mechanism of J o u r n a l P r e -p r o o f antiviral action via the inhibition of endosomal pathway (arbidol (umifenovir) and tilorone (with additional activity of interferon induction)) (Boriskin et al., 2008 , Ekins et al., 2018 .	./cache/cord-299400-j18pj11d.txt	./txt/cord-299400-j18pj11d.txt