id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314827-yqr7110e	Attia, Yasmeen M.	Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma	2020-09-04		.txt	text/plain	6483	300	28	Since HCC almost exclusively develops in patients with chronic liver diseases, injury of liver cells can promote the progression to HCC over a long period of time [11] driven by a number of cytokines and inflammatory mediators along with aberrant activity of several signaling pathways, as shown in Fig. 8 .1 (will be discussed later). Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma and HBV-and HCV-related proteins induction are among the mechanisms by which the Ras/ Raf/MAPK pathway can be activated toward HCC development [30] . Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma (genetically induced liver tumors and patientderived xenografts [PDXs]) for HCC to show significant reduction in the tumor growth after oral administration of NEN compared to niclosamide. Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma phenotypic events starting with induction of cell cycle arrest at G0/G12 phase accompanied with significant reduction in cell growth with elevated levels of KLF6/p21 protein content in HepG-2 cell line.	./cache/cord-314827-yqr7110e.txt	./txt/cord-314827-yqr7110e.txt