id	sid	tid	token	lemma	pos
cord-309871-y17puao2	1	1	key	key	NN
cord-309871-y17puao2	1	2	:	:	:
cord-309871-y17puao2	2	1	cord-309871-y17puao2	cord-309871-y17puao2	NNS
cord-309871-y17puao2	2	2	authors	author	NNS
cord-309871-y17puao2	2	3	:	:	:
cord-309871-y17puao2	2	4	Scherrmann	Scherrmann	NNP
cord-309871-y17puao2	2	5	,	,	,
cord-309871-y17puao2	2	6	JM	JM	NNP
cord-309871-y17puao2	2	7	.	.	.
cord-309871-y17puao2	3	1	title	title	NN
cord-309871-y17puao2	3	2	:	:	:
cord-309871-y17puao2	4	1	Intracellular	Intracellular	NNP
cord-309871-y17puao2	4	2	ABCB1	ABCB1	NNP
cord-309871-y17puao2	5	1	as	as	IN
cord-309871-y17puao2	5	2	a	a	DT
cord-309871-y17puao2	5	3	Possible	possible	JJ
cord-309871-y17puao2	5	4	Mechanism	Mechanism	NNP
cord-309871-y17puao2	5	5	to	to	TO
cord-309871-y17puao2	5	6	Explain	explain	VB
cord-309871-y17puao2	5	7	the	the	DT
cord-309871-y17puao2	5	8	Synergistic	Synergistic	NNP
cord-309871-y17puao2	5	9	Effect	Effect	NNP
cord-309871-y17puao2	5	10	of	of	IN
cord-309871-y17puao2	5	11	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-309871-y17puao2	5	12	-	-	HYPH
cord-309871-y17puao2	5	13	Azithromycin	Azithromycin	NNP
cord-309871-y17puao2	5	14	Combination	Combination	NNP
cord-309871-y17puao2	5	15	in	in	IN
cord-309871-y17puao2	5	16	COVID-19	COVID-19	NNP
cord-309871-y17puao2	5	17	Therapy	Therapy	NNP
cord-309871-y17puao2	5	18	date	date	NN
cord-309871-y17puao2	5	19	:	:	:
cord-309871-y17puao2	5	20	2020	2020	CD
cord-309871-y17puao2	5	21	-	-	HYPH
cord-309871-y17puao2	5	22	06	06	CD
cord-309871-y17puao2	5	23	-	-	SYM
cord-309871-y17puao2	5	24	12	12	CD
cord-309871-y17puao2	5	25	journal	journal	NN
cord-309871-y17puao2	5	26	:	:	:
cord-309871-y17puao2	6	1	AAPS	AAPS	NNP
cord-309871-y17puao2	6	2	J	J	NNP
cord-309871-y17puao2	6	3	DOI	DOI	NNP
cord-309871-y17puao2	6	4	:	:	:
cord-309871-y17puao2	6	5	10.1208	10.1208	CD
cord-309871-y17puao2	6	6	/	/	SYM
cord-309871-y17puao2	6	7	s12248	s12248	CD
cord-309871-y17puao2	6	8	-	-	HYPH
cord-309871-y17puao2	6	9	020	020	CD
cord-309871-y17puao2	6	10	-	-	HYPH
cord-309871-y17puao2	6	11	00465-w	00465-w	CD
cord-309871-y17puao2	7	1	sha	sha	NNP
cord-309871-y17puao2	7	2	:	:	:
cord-309871-y17puao2	8	1	9ad93497139140bbea830aa2144b1a4eff689ce1	9ad93497139140bbea830aa2144b1a4eff689ce1	NNP
cord-309871-y17puao2	8	2	doc_id	doc_id	CD
cord-309871-y17puao2	8	3	:	:	:
cord-309871-y17puao2	8	4	309871	309871	CD
cord-309871-y17puao2	8	5	cord_uid	cord_uid	NNS
cord-309871-y17puao2	8	6	:	:	:
cord-309871-y17puao2	8	7	y17puao2	y17puao2	NNP
cord-309871-y17puao2	9	1	The	the	DT
cord-309871-y17puao2	9	2	co	co	NN
cord-309871-y17puao2	9	3	-	-	NN
cord-309871-y17puao2	9	4	administration	administration	NN
cord-309871-y17puao2	9	5	of	of	IN
cord-309871-y17puao2	9	6	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	9	7	with	with	IN
cord-309871-y17puao2	9	8	azithromycin	azithromycin	NNP
cord-309871-y17puao2	9	9	is	be	VBZ
cord-309871-y17puao2	9	10	proposed	propose	VBN
cord-309871-y17puao2	9	11	in	in	IN
cord-309871-y17puao2	9	12	COVID-19	COVID-19	NNP
cord-309871-y17puao2	9	13	therapy	therapy	NN
cord-309871-y17puao2	9	14	.	.	.
cord-309871-y17puao2	10	1	We	-PRON-	PRP
cord-309871-y17puao2	10	2	hypothesize	hypothesize	VBP
cord-309871-y17puao2	10	3	a	a	DT
cord-309871-y17puao2	10	4	new	new	JJ
cord-309871-y17puao2	10	5	mechanism	mechanism	NN
cord-309871-y17puao2	10	6	supporting	support	VBG
cord-309871-y17puao2	10	7	the	the	DT
cord-309871-y17puao2	10	8	synergistic	synergistic	JJ
cord-309871-y17puao2	10	9	interaction	interaction	NN
cord-309871-y17puao2	10	10	between	between	IN
cord-309871-y17puao2	10	11	these	these	DT
cord-309871-y17puao2	10	12	drugs	drug	NNS
cord-309871-y17puao2	10	13	.	.	.
cord-309871-y17puao2	11	1	Azithromycin	Azithromycin	NNP
cord-309871-y17puao2	11	2	is	be	VBZ
cord-309871-y17puao2	11	3	a	a	DT
cord-309871-y17puao2	11	4	substrate	substrate	NN
cord-309871-y17puao2	11	5	of	of	IN
cord-309871-y17puao2	11	6	ABCB1	abcb1	NN
cord-309871-y17puao2	11	7	(	(	-LRB-
cord-309871-y17puao2	11	8	P	p	NN
cord-309871-y17puao2	11	9	-	-	HYPH
cord-309871-y17puao2	11	10	glycoprotein	glycoprotein	NN
cord-309871-y17puao2	11	11	)	)	-RRB-
cord-309871-y17puao2	11	12	which	which	WDT
cord-309871-y17puao2	11	13	is	be	VBZ
cord-309871-y17puao2	11	14	localized	localize	VBN
cord-309871-y17puao2	11	15	in	in	IN
cord-309871-y17puao2	11	16	endosomes	endosome	NNS
cord-309871-y17puao2	11	17	and	and	CC
cord-309871-y17puao2	11	18	lysosomes	lysosome	NNS
cord-309871-y17puao2	11	19	with	with	IN
cord-309871-y17puao2	11	20	a	a	DT
cord-309871-y17puao2	11	21	polarized	polarized	JJ
cord-309871-y17puao2	11	22	substrate	substrate	NN
cord-309871-y17puao2	11	23	transport	transport	NN
cord-309871-y17puao2	11	24	from	from	IN
cord-309871-y17puao2	11	25	the	the	DT
cord-309871-y17puao2	11	26	cell	cell	NN
cord-309871-y17puao2	11	27	cytosol	cytosol	NN
cord-309871-y17puao2	11	28	into	into	IN
cord-309871-y17puao2	11	29	the	the	DT
cord-309871-y17puao2	11	30	vesicle	vesicle	NN
cord-309871-y17puao2	11	31	interior	interior	NN
cord-309871-y17puao2	11	32	.	.	.
cord-309871-y17puao2	12	1	SARS	SARS	NNP
cord-309871-y17puao2	12	2	-	-	HYPH
cord-309871-y17puao2	12	3	CoV-2	CoV-2	NNP
cord-309871-y17puao2	12	4	and	and	CC
cord-309871-y17puao2	12	5	drugs	drug	NNS
cord-309871-y17puao2	12	6	meet	meet	VBP
cord-309871-y17puao2	12	7	in	in	IN
cord-309871-y17puao2	12	8	these	these	DT
cord-309871-y17puao2	12	9	acidic	acidic	JJ
cord-309871-y17puao2	12	10	organelles	organelle	NNS
cord-309871-y17puao2	12	11	and	and	CC
cord-309871-y17puao2	12	12	both	both	CC
cord-309871-y17puao2	12	13	basic	basic	JJ
cord-309871-y17puao2	12	14	drugs	drug	NNS
cord-309871-y17puao2	12	15	,	,	,
cord-309871-y17puao2	12	16	which	which	WDT
cord-309871-y17puao2	12	17	are	be	VBP
cord-309871-y17puao2	12	18	potent	potent	JJ
cord-309871-y17puao2	12	19	lysosomotropic	lysosomotropic	JJ
cord-309871-y17puao2	12	20	compounds	compound	NNS
cord-309871-y17puao2	12	21	,	,	,
cord-309871-y17puao2	12	22	will	will	MD
cord-309871-y17puao2	12	23	become	become	VB
cord-309871-y17puao2	12	24	protonated	protonated	JJ
cord-309871-y17puao2	12	25	and	and	CC
cord-309871-y17puao2	12	26	trapped	trap	VBN
cord-309871-y17puao2	12	27	within	within	IN
cord-309871-y17puao2	12	28	these	these	DT
cord-309871-y17puao2	12	29	vesicles	vesicle	NNS
cord-309871-y17puao2	12	30	.	.	.
cord-309871-y17puao2	13	1	Consequently	consequently	RB
cord-309871-y17puao2	13	2	,	,	,
cord-309871-y17puao2	13	3	their	-PRON-	PRP$
cord-309871-y17puao2	13	4	intra	intra	JJ
cord-309871-y17puao2	13	5	-	-	JJ
cord-309871-y17puao2	13	6	vesicular	vesicular	JJ
cord-309871-y17puao2	13	7	concentrations	concentration	NNS
cord-309871-y17puao2	13	8	can	can	MD
cord-309871-y17puao2	13	9	attain	attain	VB
cord-309871-y17puao2	13	10	low	low	JJ
cord-309871-y17puao2	13	11	micromolar	micromolar	JJ
cord-309871-y17puao2	13	12	effective	effective	JJ
cord-309871-y17puao2	13	13	cytotoxic	cytotoxic	JJ
cord-309871-y17puao2	13	14	concentrations	concentration	NNS
cord-309871-y17puao2	13	15	on	on	IN
cord-309871-y17puao2	13	16	SARS	SARS	NNP
cord-309871-y17puao2	13	17	-	-	HYPH
cord-309871-y17puao2	13	18	CoV-2	CoV-2	NNP
cord-309871-y17puao2	13	19	while	while	IN
cord-309871-y17puao2	13	20	concomitantly	concomitantly	RB
cord-309871-y17puao2	13	21	increase	increase	VBP
cord-309871-y17puao2	13	22	the	the	DT
cord-309871-y17puao2	13	23	intra	intra	JJ
cord-309871-y17puao2	13	24	-	-	JJ
cord-309871-y17puao2	13	25	vesicular	vesicular	JJ
cord-309871-y17puao2	13	26	pH	ph	NN
cord-309871-y17puao2	13	27	up	up	IN
cord-309871-y17puao2	13	28	to	to	IN
cord-309871-y17puao2	13	29	around	around	IN
cord-309871-y17puao2	13	30	neutrality	neutrality	NN
cord-309871-y17puao2	13	31	.	.	.
cord-309871-y17puao2	14	1	This	this	DT
cord-309871-y17puao2	14	2	last	last	JJ
cord-309871-y17puao2	14	3	effect	effect	NN
cord-309871-y17puao2	14	4	inhibits	inhibit	VBZ
cord-309871-y17puao2	14	5	lysosomal	lysosomal	JJ
cord-309871-y17puao2	14	6	enzyme	enzyme	NN
cord-309871-y17puao2	14	7	activities	activity	NNS
cord-309871-y17puao2	14	8	responsible	responsible	JJ
cord-309871-y17puao2	14	9	in	in	IN
cord-309871-y17puao2	14	10	virus	virus	NN
cord-309871-y17puao2	14	11	entry	entry	NN
cord-309871-y17puao2	14	12	and	and	CC
cord-309871-y17puao2	14	13	replication	replication	NN
cord-309871-y17puao2	14	14	cycle	cycle	NN
cord-309871-y17puao2	14	15	.	.	.
cord-309871-y17puao2	15	1	Based	base	VBN
cord-309871-y17puao2	15	2	on	on	IN
cord-309871-y17puao2	15	3	these	these	DT
cord-309871-y17puao2	15	4	considerations	consideration	NNS
cord-309871-y17puao2	15	5	,	,	,
cord-309871-y17puao2	15	6	we	-PRON-	PRP
cord-309871-y17puao2	15	7	hypothesize	hypothesize	VBP
cord-309871-y17puao2	15	8	that	that	IN
cord-309871-y17puao2	15	9	ABCB1	ABCB1	NNP
cord-309871-y17puao2	15	10	could	could	MD
cord-309871-y17puao2	15	11	be	be	VB
cord-309871-y17puao2	15	12	a	a	DT
cord-309871-y17puao2	15	13	possible	possible	JJ
cord-309871-y17puao2	15	14	enhancer	enhancer	NN
cord-309871-y17puao2	15	15	by	by	IN
cord-309871-y17puao2	15	16	confining	confine	VBG
cord-309871-y17puao2	15	17	azithromycin	azithromycin	NNS
cord-309871-y17puao2	15	18	more	more	RBR
cord-309871-y17puao2	15	19	extensively	extensively	RB
cord-309871-y17puao2	15	20	than	than	IN
cord-309871-y17puao2	15	21	expected	expect	VBN
cord-309871-y17puao2	15	22	when	when	WRB
cord-309871-y17puao2	15	23	the	the	DT
cord-309871-y17puao2	15	24	trapping	trapping	NN
cord-309871-y17puao2	15	25	is	be	VBZ
cord-309871-y17puao2	15	26	solely	solely	RB
cord-309871-y17puao2	15	27	dependent	dependent	JJ
cord-309871-y17puao2	15	28	on	on	IN
cord-309871-y17puao2	15	29	the	the	DT
cord-309871-y17puao2	15	30	passive	passive	JJ
cord-309871-y17puao2	15	31	diffusion	diffusion	NN
cord-309871-y17puao2	15	32	.	.	.
cord-309871-y17puao2	16	1	This	this	DT
cord-309871-y17puao2	16	2	additional	additional	JJ
cord-309871-y17puao2	16	3	mechanism	mechanism	NN
cord-309871-y17puao2	16	4	may	may	MD
cord-309871-y17puao2	16	5	therefore	therefore	RB
cord-309871-y17puao2	16	6	explain	explain	VB
cord-309871-y17puao2	16	7	the	the	DT
cord-309871-y17puao2	16	8	synergistic	synergistic	JJ
cord-309871-y17puao2	16	9	effect	effect	NN
cord-309871-y17puao2	16	10	when	when	WRB
cord-309871-y17puao2	16	11	azithromycin	azithromycin	NNP
cord-309871-y17puao2	16	12	is	be	VBZ
cord-309871-y17puao2	16	13	added	add	VBN
cord-309871-y17puao2	16	14	to	to	IN
cord-309871-y17puao2	16	15	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	16	16	,	,	,
cord-309871-y17puao2	16	17	leading	lead	VBG
cord-309871-y17puao2	16	18	to	to	IN
cord-309871-y17puao2	16	19	apparently	apparently	RB
cord-309871-y17puao2	16	20	more	more	RBR
cord-309871-y17puao2	16	21	rapid	rapid	JJ
cord-309871-y17puao2	16	22	virus	virus	NN
cord-309871-y17puao2	16	23	clearance	clearance	NN
cord-309871-y17puao2	16	24	and	and	CC
cord-309871-y17puao2	16	25	better	well	JJR
cord-309871-y17puao2	16	26	clinical	clinical	JJ
cord-309871-y17puao2	16	27	benefit	benefit	NN
cord-309871-y17puao2	16	28	,	,	,
cord-309871-y17puao2	16	29	when	when	WRB
cord-309871-y17puao2	16	30	compared	compare	VBN
cord-309871-y17puao2	16	31	to	to	IN
cord-309871-y17puao2	16	32	monotherapy	monotherapy	NN
cord-309871-y17puao2	16	33	with	with	IN
cord-309871-y17puao2	16	34	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	16	35	alone	alone	JJ
cord-309871-y17puao2	16	36	.	.	.
cord-309871-y17puao2	17	1	The	the	DT
cord-309871-y17puao2	17	2	co	co	NN
cord-309871-y17puao2	17	3	-	-	NN
cord-309871-y17puao2	17	4	administration	administration	NN
cord-309871-y17puao2	17	5	of	of	IN
cord-309871-y17puao2	17	6	the	the	DT
cord-309871-y17puao2	17	7	antimalarial	antimalarial	JJ
cord-309871-y17puao2	17	8	chloroquine	chloroquine	NN
cord-309871-y17puao2	17	9	or	or	CC
cord-309871-y17puao2	17	10	the	the	DT
cord-309871-y17puao2	17	11	anti	anti	JJ
cord-309871-y17puao2	17	12	-	-	JJ
cord-309871-y17puao2	17	13	rheumatic	rheumatic	JJ
cord-309871-y17puao2	17	14	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	17	15	with	with	IN
cord-309871-y17puao2	17	16	the	the	DT
cord-309871-y17puao2	17	17	antibacterial	antibacterial	JJ
cord-309871-y17puao2	17	18	azithromycin	azithromycin	NN
cord-309871-y17puao2	17	19	is	be	VBZ
cord-309871-y17puao2	17	20	presently	presently	RB
cord-309871-y17puao2	17	21	proposed	propose	VBN
cord-309871-y17puao2	17	22	as	as	IN
cord-309871-y17puao2	17	23	a	a	DT
cord-309871-y17puao2	17	24	therapy	therapy	NN
cord-309871-y17puao2	17	25	amidst	amidst	IN
cord-309871-y17puao2	17	26	the	the	DT
cord-309871-y17puao2	17	27	COVID-19	COVID-19	NNP
cord-309871-y17puao2	17	28	pandemic	pandemic	NN
cord-309871-y17puao2	17	29	(	(	-LRB-
cord-309871-y17puao2	17	30	1	1	CD
cord-309871-y17puao2	17	31	)	)	-RRB-
cord-309871-y17puao2	17	32	.	.	.
cord-309871-y17puao2	18	1	These	these	DT
cord-309871-y17puao2	18	2	aminoquinoline	aminoquinoline	JJ
cord-309871-y17puao2	18	3	drugs	drug	NNS
cord-309871-y17puao2	18	4	and	and	CC
cord-309871-y17puao2	18	5	azithromycin	azithromycin	NNS
cord-309871-y17puao2	18	6	are	be	VBP
cord-309871-y17puao2	18	7	being	be	VBG
cord-309871-y17puao2	18	8	repurposed	repurpose	VBN
cord-309871-y17puao2	18	9	for	for	IN
cord-309871-y17puao2	18	10	their	-PRON-	PRP$
cord-309871-y17puao2	18	11	clinical	clinical	JJ
cord-309871-y17puao2	18	12	use	use	NN
cord-309871-y17puao2	18	13	in	in	IN
cord-309871-y17puao2	18	14	COVID-19	COVID-19	NNP
cord-309871-y17puao2	18	15	,	,	,
cord-309871-y17puao2	18	16	and	and	CC
cord-309871-y17puao2	18	17	they	-PRON-	PRP
cord-309871-y17puao2	18	18	should	should	MD
cord-309871-y17puao2	18	19	be	be	VB
cord-309871-y17puao2	18	20	evaluated	evaluate	VBN
cord-309871-y17puao2	18	21	according	accord	VBG
cord-309871-y17puao2	18	22	to	to	IN
cord-309871-y17puao2	18	23	current	current	JJ
cord-309871-y17puao2	18	24	practices	practice	NNS
cord-309871-y17puao2	18	25	of	of	IN
cord-309871-y17puao2	18	26	drug	drug	NN
cord-309871-y17puao2	18	27	clinical	clinical	JJ
cord-309871-y17puao2	18	28	trials	trial	NNS
cord-309871-y17puao2	18	29	for	for	IN
cord-309871-y17puao2	18	30	this	this	DT
cord-309871-y17puao2	18	31	indication	indication	NN
cord-309871-y17puao2	18	32	.	.	.
cord-309871-y17puao2	19	1	Although	although	IN
cord-309871-y17puao2	19	2	this	this	DT
cord-309871-y17puao2	19	3	process	process	NN
cord-309871-y17puao2	19	4	is	be	VBZ
cord-309871-y17puao2	19	5	normally	normally	RB
cord-309871-y17puao2	19	6	time	time	NN
cord-309871-y17puao2	19	7	-	-	HYPH
cord-309871-y17puao2	19	8	consuming	consume	VBG
cord-309871-y17puao2	19	9	,	,	,
cord-309871-y17puao2	19	10	population	population	NN
cord-309871-y17puao2	19	11	,	,	,
cord-309871-y17puao2	19	12	media	medium	NNS
cord-309871-y17puao2	19	13	,	,	,
cord-309871-y17puao2	19	14	and	and	CC
cord-309871-y17puao2	19	15	political	political	JJ
cord-309871-y17puao2	19	16	pressures	pressure	NNS
cord-309871-y17puao2	19	17	have	have	VBP
cord-309871-y17puao2	19	18	propelled	propel	VBN
cord-309871-y17puao2	19	19	the	the	DT
cord-309871-y17puao2	19	20	use	use	NN
cord-309871-y17puao2	19	21	of	of	IN
cord-309871-y17puao2	19	22	this	this	DT
cord-309871-y17puao2	19	23	combined	combine	VBN
cord-309871-y17puao2	19	24	therapy	therapy	NN
cord-309871-y17puao2	19	25	on	on	IN
cord-309871-y17puao2	19	26	an	an	DT
cord-309871-y17puao2	19	27	emergency	emergency	NN
cord-309871-y17puao2	19	28	basis	basis	NN
cord-309871-y17puao2	19	29	,	,	,
cord-309871-y17puao2	19	30	thus	thus	RB
cord-309871-y17puao2	19	31	opening	open	VBG
cord-309871-y17puao2	19	32	controversial	controversial	JJ
cord-309871-y17puao2	19	33	pro	pro	JJ
cord-309871-y17puao2	19	34	and	and	CC
cord-309871-y17puao2	19	35	con	con	JJ
cord-309871-y17puao2	19	36	debates	debate	NNS
cord-309871-y17puao2	19	37	.	.	.
cord-309871-y17puao2	20	1	Moreover	moreover	RB
cord-309871-y17puao2	20	2	,	,	,
cord-309871-y17puao2	20	3	most	most	JJS
cord-309871-y17puao2	20	4	of	of	IN
cord-309871-y17puao2	20	5	the	the	DT
cord-309871-y17puao2	20	6	different	different	JJ
cord-309871-y17puao2	20	7	aminoquinoline	aminoquinoline	JJ
cord-309871-y17puao2	20	8	clinical	clinical	JJ
cord-309871-y17puao2	20	9	trials	trial	NNS
cord-309871-y17puao2	20	10	over	over	IN
cord-309871-y17puao2	20	11	the	the	DT
cord-309871-y17puao2	20	12	world	world	NN
cord-309871-y17puao2	20	13	are	be	VBP
cord-309871-y17puao2	20	14	not	not	RB
cord-309871-y17puao2	20	15	comparable	comparable	JJ
cord-309871-y17puao2	20	16	as	as	IN
cord-309871-y17puao2	20	17	they	-PRON-	PRP
cord-309871-y17puao2	20	18	differ	differ	VBP
cord-309871-y17puao2	20	19	in	in	IN
cord-309871-y17puao2	20	20	terms	term	NNS
cord-309871-y17puao2	20	21	of	of	IN
cord-309871-y17puao2	20	22	mono	mono	NN
cord-309871-y17puao2	20	23	or	or	CC
cord-309871-y17puao2	20	24	bi	bi	JJ
cord-309871-y17puao2	20	25	-	-	NN
cord-309871-y17puao2	20	26	therapy	therapy	NN
cord-309871-y17puao2	20	27	choice	choice	NN
cord-309871-y17puao2	20	28	,	,	,
cord-309871-y17puao2	20	29	dosage	dosage	NN
cord-309871-y17puao2	20	30	regimen	regimen	NN
cord-309871-y17puao2	20	31	,	,	,
cord-309871-y17puao2	20	32	and	and	CC
cord-309871-y17puao2	20	33	optimal	optimal	JJ
cord-309871-y17puao2	20	34	time	time	NN
cord-309871-y17puao2	20	35	of	of	IN
cord-309871-y17puao2	20	36	administration	administration	NN
cord-309871-y17puao2	20	37	versus	versus	IN
cord-309871-y17puao2	20	38	the	the	DT
cord-309871-y17puao2	20	39	disease	disease	NN
cord-309871-y17puao2	20	40	time	time	NN
cord-309871-y17puao2	20	41	course	course	NN
cord-309871-y17puao2	20	42	and	and	CC
cord-309871-y17puao2	20	43	severity	severity	NN
cord-309871-y17puao2	20	44	.	.	.
cord-309871-y17puao2	21	1	Several	several	JJ
cord-309871-y17puao2	21	2	Chinese	chinese	JJ
cord-309871-y17puao2	21	3	clinical	clinical	JJ
cord-309871-y17puao2	21	4	trials	trial	NNS
cord-309871-y17puao2	21	5	have	have	VBP
cord-309871-y17puao2	21	6	been	be	VBN
cord-309871-y17puao2	21	7	based	base	VBN
cord-309871-y17puao2	21	8	on	on	IN
cord-309871-y17puao2	21	9	the	the	DT
cord-309871-y17puao2	21	10	sole	sole	JJ
cord-309871-y17puao2	21	11	chloroquine	chloroquine	NNP
cord-309871-y17puao2	21	12	or	or	CC
cord-309871-y17puao2	21	13	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	21	14	administration	administration	NN
cord-309871-y17puao2	21	15	and	and	CC
cord-309871-y17puao2	21	16	their	-PRON-	PRP$
cord-309871-y17puao2	21	17	clinical	clinical	JJ
cord-309871-y17puao2	21	18	efficacies	efficacy	NNS
cord-309871-y17puao2	21	19	remain	remain	VBP
cord-309871-y17puao2	21	20	uncertain	uncertain	JJ
cord-309871-y17puao2	21	21	(	(	-LRB-
cord-309871-y17puao2	21	22	2	2	CD
cord-309871-y17puao2	21	23	)	)	-RRB-
cord-309871-y17puao2	21	24	(	(	-LRB-
cord-309871-y17puao2	21	25	3	3	LS
cord-309871-y17puao2	21	26	)	)	-RRB-
cord-309871-y17puao2	21	27	(	(	-LRB-
cord-309871-y17puao2	21	28	4	4	LS
cord-309871-y17puao2	21	29	)	)	-RRB-
cord-309871-y17puao2	21	30	.	.	.
cord-309871-y17puao2	22	1	Additionally	additionally	RB
cord-309871-y17puao2	22	2	,	,	,
cord-309871-y17puao2	22	3	most	most	JJS
cord-309871-y17puao2	22	4	of	of	IN
cord-309871-y17puao2	22	5	these	these	DT
cord-309871-y17puao2	22	6	methodological	methodological	JJ
cord-309871-y17puao2	22	7	protocols	protocol	NNS
cord-309871-y17puao2	22	8	suffer	suffer	VBP
cord-309871-y17puao2	22	9	from	from	IN
cord-309871-y17puao2	22	10	major	major	JJ
cord-309871-y17puao2	22	11	concerns	concern	NNS
cord-309871-y17puao2	22	12	in	in	IN
cord-309871-y17puao2	22	13	term	term	NN
cord-309871-y17puao2	22	14	of	of	IN
cord-309871-y17puao2	22	15	trial	trial	NN
cord-309871-y17puao2	22	16	design	design	NN
cord-309871-y17puao2	22	17	quality	quality	NN
cord-309871-y17puao2	22	18	such	such	JJ
cord-309871-y17puao2	22	19	as	as	IN
cord-309871-y17puao2	22	20	inappropriateness	inappropriateness	NN
cord-309871-y17puao2	22	21	in	in	IN
cord-309871-y17puao2	22	22	randomization	randomization	NN
cord-309871-y17puao2	22	23	,	,	,
cord-309871-y17puao2	22	24	patient	patient	JJ
cord-309871-y17puao2	22	25	population	population	NN
cord-309871-y17puao2	22	26	size	size	NN
cord-309871-y17puao2	22	27	,	,	,
cord-309871-y17puao2	22	28	and	and	CC
cord-309871-y17puao2	22	29	other	other	JJ
cord-309871-y17puao2	22	30	limiting	limit	VBG
cord-309871-y17puao2	22	31	factors	factor	NNS
cord-309871-y17puao2	22	32	(	(	-LRB-
cord-309871-y17puao2	22	33	5	5	CD
cord-309871-y17puao2	22	34	,	,	,
cord-309871-y17puao2	22	35	6	6	CD
cord-309871-y17puao2	22	36	)	)	-RRB-
cord-309871-y17puao2	22	37	.	.	.
cord-309871-y17puao2	23	1	The	the	DT
cord-309871-y17puao2	23	2	purpose	purpose	NN
cord-309871-y17puao2	23	3	of	of	IN
cord-309871-y17puao2	23	4	this	this	DT
cord-309871-y17puao2	23	5	commentary	commentary	NN
cord-309871-y17puao2	23	6	is	be	VBZ
cord-309871-y17puao2	23	7	to	to	TO
cord-309871-y17puao2	23	8	discuss	discuss	VB
cord-309871-y17puao2	23	9	the	the	DT
cord-309871-y17puao2	23	10	possible	possible	JJ
cord-309871-y17puao2	23	11	rationale	rationale	NN
cord-309871-y17puao2	23	12	for	for	IN
cord-309871-y17puao2	23	13	co	co	NN
cord-309871-y17puao2	23	14	-	-	JJ
cord-309871-y17puao2	23	15	administering	administer	VBG
cord-309871-y17puao2	23	16	the	the	DT
cord-309871-y17puao2	23	17	antibiotic	antibiotic	JJ
cord-309871-y17puao2	23	18	azithromycin	azithromycin	NNP
cord-309871-y17puao2	23	19	with	with	IN
cord-309871-y17puao2	23	20	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	23	21	,	,	,
cord-309871-y17puao2	23	22	recognizing	recognize	VBG
cord-309871-y17puao2	23	23	that	that	IN
cord-309871-y17puao2	23	24	azithromycin	azithromycin	NNP
cord-309871-y17puao2	23	25	is	be	VBZ
cord-309871-y17puao2	23	26	not	not	RB
cord-309871-y17puao2	23	27	being	be	VBG
cord-309871-y17puao2	23	28	used	use	VBN
cord-309871-y17puao2	23	29	for	for	IN
cord-309871-y17puao2	23	30	its	-PRON-	PRP$
cord-309871-y17puao2	23	31	antibacterial	antibacterial	JJ
cord-309871-y17puao2	23	32	activity	activity	NN
cord-309871-y17puao2	23	33	but	but	CC
cord-309871-y17puao2	23	34	for	for	IN
cord-309871-y17puao2	23	35	its	-PRON-	PRP$
cord-309871-y17puao2	23	36	additive	additive	NN
cord-309871-y17puao2	23	37	or	or	CC
cord-309871-y17puao2	23	38	synergistic	synergistic	JJ
cord-309871-y17puao2	23	39	effect	effect	NN
cord-309871-y17puao2	23	40	on	on	IN
cord-309871-y17puao2	23	41	the	the	DT
cord-309871-y17puao2	23	42	antiviral	antiviral	JJ
cord-309871-y17puao2	23	43	action	action	NN
cord-309871-y17puao2	23	44	of	of	IN
cord-309871-y17puao2	23	45	the	the	DT
cord-309871-y17puao2	23	46	aminoquinolines	aminoquinoline	NNS
cord-309871-y17puao2	23	47	(	(	-LRB-
cord-309871-y17puao2	23	48	7	7	CD
cord-309871-y17puao2	23	49	)	)	-RRB-
cord-309871-y17puao2	23	50	.	.	.
cord-309871-y17puao2	24	1	Moreover	moreover	RB
cord-309871-y17puao2	24	2	,	,	,
cord-309871-y17puao2	24	3	several	several	JJ
cord-309871-y17puao2	24	4	in	in	IN
cord-309871-y17puao2	24	5	vitro	vitro	FW
cord-309871-y17puao2	24	6	and	and	CC
cord-309871-y17puao2	24	7	in	in	IN
cord-309871-y17puao2	24	8	vivo	vivo	NNP
cord-309871-y17puao2	24	9	studies	study	NNS
cord-309871-y17puao2	24	10	support	support	VBP
cord-309871-y17puao2	24	11	additional	additional	JJ
cord-309871-y17puao2	24	12	antiviral	antiviral	JJ
cord-309871-y17puao2	24	13	properties	property	NNS
cord-309871-y17puao2	24	14	of	of	IN
cord-309871-y17puao2	24	15	azithromycin	azithromycin	NN
cord-309871-y17puao2	24	16	although	although	IN
cord-309871-y17puao2	24	17	the	the	DT
cord-309871-y17puao2	24	18	drug	drug	NN
cord-309871-y17puao2	24	19	is	be	VBZ
cord-309871-y17puao2	24	20	not	not	RB
cord-309871-y17puao2	24	21	approved	approve	VBN
cord-309871-y17puao2	24	22	for	for	IN
cord-309871-y17puao2	24	23	the	the	DT
cord-309871-y17puao2	24	24	treatment	treatment	NN
cord-309871-y17puao2	24	25	of	of	IN
cord-309871-y17puao2	24	26	viral	viral	JJ
cord-309871-y17puao2	24	27	infections	infection	NNS
cord-309871-y17puao2	24	28	(	(	-LRB-
cord-309871-y17puao2	24	29	8)	8)	NNP
cord-309871-y17puao2	24	30	.	.	.
cord-309871-y17puao2	25	1	Here	here	RB
cord-309871-y17puao2	25	2	,	,	,
cord-309871-y17puao2	25	3	we	-PRON-	PRP
cord-309871-y17puao2	25	4	provide	provide	VBP
cord-309871-y17puao2	25	5	comments	comment	NNS
cord-309871-y17puao2	25	6	and	and	CC
cord-309871-y17puao2	25	7	hypotheses	hypothesis	NNS
cord-309871-y17puao2	25	8	to	to	TO
cord-309871-y17puao2	25	9	develop	develop	VB
cord-309871-y17puao2	25	10	a	a	DT
cord-309871-y17puao2	25	11	rationale	rationale	NN
cord-309871-y17puao2	25	12	for	for	IN
cord-309871-y17puao2	25	13	this	this	DT
cord-309871-y17puao2	25	14	drug	drug	NN
cord-309871-y17puao2	25	15	combination	combination	NN
cord-309871-y17puao2	25	16	based	base	VBN
cord-309871-y17puao2	25	17	upon	upon	IN
cord-309871-y17puao2	25	18	sub	sub	JJ
cord-309871-y17puao2	25	19	-	-	JJ
cord-309871-y17puao2	25	20	cellular	cellular	JJ
cord-309871-y17puao2	25	21	pharmacokinetic	pharmacokinetic	JJ
cord-309871-y17puao2	25	22	and	and	CC
cord-309871-y17puao2	25	23	pharmacodynamic	pharmacodynamic	JJ
cord-309871-y17puao2	25	24	arguments	argument	NNS
cord-309871-y17puao2	25	25	.	.	.
cord-309871-y17puao2	26	1	Two	two	CD
cord-309871-y17puao2	26	2	recent	recent	JJ
cord-309871-y17puao2	26	3	works	work	NNS
cord-309871-y17puao2	26	4	have	have	VBP
cord-309871-y17puao2	26	5	detailed	detail	VBN
cord-309871-y17puao2	26	6	the	the	DT
cord-309871-y17puao2	26	7	targets	target	NNS
cord-309871-y17puao2	26	8	and	and	CC
cord-309871-y17puao2	26	9	cellular	cellular	JJ
cord-309871-y17puao2	26	10	pathways	pathway	NNS
cord-309871-y17puao2	26	11	supporting	support	VBG
cord-309871-y17puao2	26	12	the	the	DT
cord-309871-y17puao2	26	13	antiviral	antiviral	JJ
cord-309871-y17puao2	26	14	activity	activity	NN
cord-309871-y17puao2	26	15	of	of	IN
cord-309871-y17puao2	26	16	chloroquine	chloroquine	NNP
cord-309871-y17puao2	26	17	and	and	CC
cord-309871-y17puao2	26	18	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	26	19	(	(	-LRB-
cord-309871-y17puao2	26	20	4	4	CD
cord-309871-y17puao2	26	21	,	,	,
cord-309871-y17puao2	26	22	9	9	CD
cord-309871-y17puao2	26	23	)	)	-RRB-
cord-309871-y17puao2	26	24	.	.	.
cord-309871-y17puao2	27	1	In	in	IN
cord-309871-y17puao2	27	2	fact	fact	NN
cord-309871-y17puao2	27	3	,	,	,
cord-309871-y17puao2	27	4	the	the	DT
cord-309871-y17puao2	27	5	attempt	attempt	NN
cord-309871-y17puao2	27	6	to	to	TO
cord-309871-y17puao2	27	7	combine	combine	VB
cord-309871-y17puao2	27	8	chloroquine	chloroquine	NN
cord-309871-y17puao2	27	9	and	and	CC
cord-309871-y17puao2	27	10	azithromycin	azithromycin	NNP
cord-309871-y17puao2	27	11	started	start	VBD
cord-309871-y17puao2	27	12	with	with	IN
cord-309871-y17puao2	27	13	the	the	DT
cord-309871-y17puao2	27	14	observation	observation	NN
cord-309871-y17puao2	27	15	of	of	IN
cord-309871-y17puao2	27	16	resistance	resistance	NN
cord-309871-y17puao2	27	17	of	of	IN
cord-309871-y17puao2	27	18	Plasmodium	Plasmodium	NNP
cord-309871-y17puao2	27	19	falciparum	falciparum	NNS
cord-309871-y17puao2	27	20	to	to	IN
cord-309871-y17puao2	27	21	chloroquine	chloroquine	NN
cord-309871-y17puao2	27	22	.	.	.
cord-309871-y17puao2	28	1	Gingras	Gingras	NNP
cord-309871-y17puao2	28	2	and	and	CC
cord-309871-y17puao2	28	3	Jensen	Jensen	NNP
cord-309871-y17puao2	28	4	were	be	VBD
cord-309871-y17puao2	28	5	the	the	DT
cord-309871-y17puao2	28	6	first	first	JJ
cord-309871-y17puao2	28	7	in	in	IN
cord-309871-y17puao2	28	8	1992	1992	CD
cord-309871-y17puao2	28	9	to	to	TO
cord-309871-y17puao2	28	10	demonstrate	demonstrate	VB
cord-309871-y17puao2	28	11	in	in	IN
cord-309871-y17puao2	28	12	vitro	vitro	FW
cord-309871-y17puao2	28	13	that	that	IN
cord-309871-y17puao2	28	14	the	the	DT
cord-309871-y17puao2	28	15	association	association	NN
cord-309871-y17puao2	28	16	of	of	IN
cord-309871-y17puao2	28	17	azithromycin	azithromycin	NNP
cord-309871-y17puao2	28	18	to	to	IN
cord-309871-y17puao2	28	19	chloroquine	chloroquine	NN
cord-309871-y17puao2	28	20	reversed	reverse	VBD
cord-309871-y17puao2	28	21	the	the	DT
cord-309871-y17puao2	28	22	resistance	resistance	NN
cord-309871-y17puao2	28	23	of	of	IN
cord-309871-y17puao2	28	24	chloroquine	chloroquine	NN
cord-309871-y17puao2	28	25	-	-	HYPH
cord-309871-y17puao2	28	26	resistant	resistant	JJ
cord-309871-y17puao2	28	27	strains	strain	NNS
cord-309871-y17puao2	28	28	of	of	IN
cord-309871-y17puao2	28	29	P.	P.	NNP
cord-309871-y17puao2	28	30	falciparum	falciparum	NN
cord-309871-y17puao2	28	31	(	(	-LRB-
cord-309871-y17puao2	28	32	10	10	CD
cord-309871-y17puao2	28	33	)	)	-RRB-
cord-309871-y17puao2	28	34	.	.	.
cord-309871-y17puao2	29	1	Subsequent	subsequent	JJ
cord-309871-y17puao2	29	2	in	in	IN
cord-309871-y17puao2	29	3	vivo	vivo	NN
cord-309871-y17puao2	29	4	and	and	CC
cord-309871-y17puao2	29	5	clinical	clinical	JJ
cord-309871-y17puao2	29	6	studies	study	NNS
cord-309871-y17puao2	29	7	have	have	VBP
cord-309871-y17puao2	29	8	validated	validate	VBN
cord-309871-y17puao2	29	9	this	this	DT
cord-309871-y17puao2	29	10	dual	dual	JJ
cord-309871-y17puao2	29	11	administration	administration	NN
cord-309871-y17puao2	29	12	in	in	IN
cord-309871-y17puao2	29	13	malaria	malaria	NN
cord-309871-y17puao2	29	14	chemotherapy	chemotherapy	NN
cord-309871-y17puao2	29	15	(	(	-LRB-
cord-309871-y17puao2	29	16	11	11	CD
cord-309871-y17puao2	29	17	,	,	,
cord-309871-y17puao2	29	18	12	12	CD
cord-309871-y17puao2	29	19	)	)	-RRB-
cord-309871-y17puao2	29	20	.	.	.
cord-309871-y17puao2	30	1	An	an	DT
cord-309871-y17puao2	30	2	inverted	inverted	JJ
cord-309871-y17puao2	30	3	association	association	NN
cord-309871-y17puao2	30	4	was	be	VBD
cord-309871-y17puao2	30	5	also	also	RB
cord-309871-y17puao2	30	6	found	find	VBN
cord-309871-y17puao2	30	7	effective	effective	JJ
cord-309871-y17puao2	30	8	to	to	TO
cord-309871-y17puao2	30	9	kill	kill	VB
cord-309871-y17puao2	30	10	intracellular	intracellular	JJ
cord-309871-y17puao2	30	11	bacteria	bacteria	NNS
cord-309871-y17puao2	30	12	,	,	,
cord-309871-y17puao2	30	13	such	such	JJ
cord-309871-y17puao2	30	14	as	as	IN
cord-309871-y17puao2	30	15	Staphylococcus	Staphylococcus	NNP
cord-309871-y17puao2	30	16	aureus	aureus	NN
cord-309871-y17puao2	30	17	when	when	WRB
cord-309871-y17puao2	30	18	chloroquine	chloroquine	NN
cord-309871-y17puao2	30	19	was	be	VBD
cord-309871-y17puao2	30	20	used	use	VBN
cord-309871-y17puao2	30	21	to	to	TO
cord-309871-y17puao2	30	22	synergize	synergize	VB
cord-309871-y17puao2	30	23	the	the	DT
cord-309871-y17puao2	30	24	effect	effect	NN
cord-309871-y17puao2	30	25	of	of	IN
cord-309871-y17puao2	30	26	the	the	DT
cord-309871-y17puao2	30	27	antibiotic	antibiotic	JJ
cord-309871-y17puao2	30	28	azithromycin	azithromycin	NNP
cord-309871-y17puao2	30	29	(	(	-LRB-
cord-309871-y17puao2	30	30	13	13	CD
cord-309871-y17puao2	30	31	)	)	-RRB-
cord-309871-y17puao2	30	32	.	.	.
cord-309871-y17puao2	31	1	Moreover	moreover	RB
cord-309871-y17puao2	31	2	,	,	,
cord-309871-y17puao2	31	3	this	this	DT
cord-309871-y17puao2	31	4	drug	drug	NN
cord-309871-y17puao2	31	5	combination	combination	NN
cord-309871-y17puao2	31	6	was	be	VBD
cord-309871-y17puao2	31	7	also	also	RB
cord-309871-y17puao2	31	8	extended	extend	VBN
cord-309871-y17puao2	31	9	to	to	IN
cord-309871-y17puao2	31	10	virus	virus	NN
cord-309871-y17puao2	31	11	diseases	disease	NNS
cord-309871-y17puao2	31	12	with	with	IN
cord-309871-y17puao2	31	13	many	many	JJ
cord-309871-y17puao2	31	14	clinical	clinical	JJ
cord-309871-y17puao2	31	15	studies	study	NNS
cord-309871-y17puao2	31	16	but	but	CC
cord-309871-y17puao2	31	17	most	most	JJS
cord-309871-y17puao2	31	18	of	of	IN
cord-309871-y17puao2	31	19	them	-PRON-	PRP
cord-309871-y17puao2	31	20	were	be	VBD
cord-309871-y17puao2	31	21	moderately	moderately	RB
cord-309871-y17puao2	31	22	conclusive	conclusive	JJ
cord-309871-y17puao2	31	23	(	(	-LRB-
cord-309871-y17puao2	31	24	14	14	CD
cord-309871-y17puao2	31	25	,	,	,
cord-309871-y17puao2	31	26	15	15	CD
cord-309871-y17puao2	31	27	)	)	-RRB-
cord-309871-y17puao2	31	28	.	.	.
cord-309871-y17puao2	32	1	Nevertheless	nevertheless	RB
cord-309871-y17puao2	32	2	,	,	,
cord-309871-y17puao2	32	3	for	for	IN
cord-309871-y17puao2	32	4	each	each	DT
cord-309871-y17puao2	32	5	recent	recent	JJ
cord-309871-y17puao2	32	6	and	and	CC
cord-309871-y17puao2	32	7	new	new	JJ
cord-309871-y17puao2	32	8	virus	virus	NN
cord-309871-y17puao2	32	9	infections	infection	NNS
cord-309871-y17puao2	32	10	,	,	,
cord-309871-y17puao2	32	11	the	the	DT
cord-309871-y17puao2	32	12	chloroquineazithromycin	chloroquineazithromycin	NNS
cord-309871-y17puao2	32	13	combination	combination	NN
cord-309871-y17puao2	32	14	strategy	strategy	NN
cord-309871-y17puao2	32	15	reappears	reappear	VBZ
cord-309871-y17puao2	32	16	as	as	IN
cord-309871-y17puao2	32	17	a	a	DT
cord-309871-y17puao2	32	18	possible	possible	JJ
cord-309871-y17puao2	32	19	miraculous	miraculous	JJ
cord-309871-y17puao2	32	20	solution	solution	NN
cord-309871-y17puao2	32	21	such	such	JJ
cord-309871-y17puao2	32	22	as	as	IN
cord-309871-y17puao2	32	23	in	in	IN
cord-309871-y17puao2	32	24	Ebola	Ebola	NNP
cord-309871-y17puao2	32	25	,	,	,
cord-309871-y17puao2	32	26	SARS	SARS	NNP
cord-309871-y17puao2	32	27	and	and	CC
cord-309871-y17puao2	32	28	MERS	MERS	NNP
cord-309871-y17puao2	32	29	,	,	,
cord-309871-y17puao2	32	30	HIV	HIV	NNP
cord-309871-y17puao2	32	31	diseases	disease	NNS
cord-309871-y17puao2	32	32	,	,	,
cord-309871-y17puao2	32	33	and	and	CC
cord-309871-y17puao2	32	34	now	now	RB
cord-309871-y17puao2	32	35	with	with	IN
cord-309871-y17puao2	32	36	SARS	SARS	NNP
cord-309871-y17puao2	32	37	-	-	HYPH
cord-309871-y17puao2	32	38	CoV-2	CoV-2	NNP
cord-309871-y17puao2	32	39	in	in	IN
cord-309871-y17puao2	32	40	COVID-19	COVID-19	NNP
cord-309871-y17puao2	32	41	(	(	-LRB-
cord-309871-y17puao2	32	42	16	16	CD
cord-309871-y17puao2	32	43	)	)	-RRB-
cord-309871-y17puao2	32	44	(	(	-LRB-
cord-309871-y17puao2	32	45	17	17	CD
cord-309871-y17puao2	32	46	)	)	-RRB-
cord-309871-y17puao2	32	47	(	(	-LRB-
cord-309871-y17puao2	32	48	18	18	CD
cord-309871-y17puao2	32	49	)	)	-RRB-
cord-309871-y17puao2	32	50	(	(	-LRB-
cord-309871-y17puao2	32	51	19	19	CD
cord-309871-y17puao2	32	52	)	)	-RRB-
cord-309871-y17puao2	32	53	.	.	.
cord-309871-y17puao2	33	1	In	in	IN
cord-309871-y17puao2	33	2	this	this	DT
cord-309871-y17puao2	33	3	last	last	JJ
cord-309871-y17puao2	33	4	indication	indication	NN
cord-309871-y17puao2	33	5	,	,	,
cord-309871-y17puao2	33	6	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	33	7	,	,	,
cord-309871-y17puao2	33	8	mostly	mostly	RB
cord-309871-y17puao2	33	9	used	use	VBN
cord-309871-y17puao2	33	10	for	for	IN
cord-309871-y17puao2	33	11	treating	treat	VBG
cord-309871-y17puao2	33	12	severe	severe	JJ
cord-309871-y17puao2	33	13	rheumatic	rheumatic	JJ
cord-309871-y17puao2	33	14	diseases	disease	NNS
cord-309871-y17puao2	33	15	,	,	,
cord-309871-y17puao2	33	16	is	be	VBZ
cord-309871-y17puao2	33	17	preferred	prefer	VBN
cord-309871-y17puao2	33	18	to	to	IN
cord-309871-y17puao2	33	19	chloroquine	chloroquine	NN
cord-309871-y17puao2	33	20	as	as	IN
cord-309871-y17puao2	33	21	more	more	RBR
cord-309871-y17puao2	33	22	effective	effective	JJ
cord-309871-y17puao2	33	23	in	in	IN
cord-309871-y17puao2	33	24	vitro	vitro	FW
cord-309871-y17puao2	33	25	and	and	CC
cord-309871-y17puao2	33	26	clinically	clinically	RB
cord-309871-y17puao2	33	27	safer	safe	JJR
cord-309871-y17puao2	33	28	than	than	IN
cord-309871-y17puao2	33	29	chloroquine	chloroquine	NN
cord-309871-y17puao2	33	30	(	(	-LRB-
cord-309871-y17puao2	33	31	20	20	CD
cord-309871-y17puao2	33	32	)	)	-RRB-
cord-309871-y17puao2	33	33	.	.	.
cord-309871-y17puao2	34	1	Moreover	moreover	RB
cord-309871-y17puao2	34	2	,	,	,
cord-309871-y17puao2	34	3	a	a	DT
cord-309871-y17puao2	34	4	recent	recent	JJ
cord-309871-y17puao2	34	5	physiologically	physiologically	RB
cord-309871-y17puao2	34	6	based	base	VBN
cord-309871-y17puao2	34	7	pharmacokinetic	pharmacokinetic	JJ
cord-309871-y17puao2	34	8	(	(	-LRB-
cord-309871-y17puao2	34	9	PBPK	PBPK	NNP
cord-309871-y17puao2	34	10	)	)	-RRB-
cord-309871-y17puao2	34	11	model	model	NN
cord-309871-y17puao2	34	12	,	,	,
cord-309871-y17puao2	34	13	combining	combine	VBG
cord-309871-y17puao2	34	14	in	in	IN
cord-309871-y17puao2	34	15	vitro	vitro	FW
cord-309871-y17puao2	34	16	data	datum	NNS
cord-309871-y17puao2	34	17	with	with	IN
cord-309871-y17puao2	34	18	published	publish	VBN
cord-309871-y17puao2	34	19	drug	drug	NN
cord-309871-y17puao2	34	20	pharmacokinetics	pharmacokinetic	NNS
cord-309871-y17puao2	34	21	,	,	,
cord-309871-y17puao2	34	22	was	be	VBD
cord-309871-y17puao2	34	23	interestingly	interestingly	RB
cord-309871-y17puao2	34	24	developed	develop	VBN
cord-309871-y17puao2	34	25	to	to	TO
cord-309871-y17puao2	34	26	predict	predict	VB
cord-309871-y17puao2	34	27	the	the	DT
cord-309871-y17puao2	34	28	optimal	optimal	JJ
cord-309871-y17puao2	34	29	dosage	dosage	NN
cord-309871-y17puao2	34	30	regimen	regimen	NN
cord-309871-y17puao2	34	31	of	of	IN
cord-309871-y17puao2	34	32	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	34	33	in	in	IN
cord-309871-y17puao2	34	34	COVID-19	COVID-19	NNP
cord-309871-y17puao2	34	35	(	(	-LRB-
cord-309871-y17puao2	34	36	21	21	CD
cord-309871-y17puao2	34	37	)	)	-RRB-
cord-309871-y17puao2	34	38	.	.	.
cord-309871-y17puao2	35	1	Another	another	DT
cord-309871-y17puao2	35	2	recent	recent	JJ
cord-309871-y17puao2	35	3	mechanistic	mechanistic	JJ
cord-309871-y17puao2	35	4	PK	PK	NNP
cord-309871-y17puao2	35	5	modeling	modeling	NN
cord-309871-y17puao2	35	6	study	study	NN
cord-309871-y17puao2	35	7	including	include	VBG
cord-309871-y17puao2	35	8	efficacy	efficacy	NN
cord-309871-y17puao2	35	9	with	with	IN
cord-309871-y17puao2	35	10	historical	historical	JJ
cord-309871-y17puao2	35	11	data	datum	NNS
cord-309871-y17puao2	35	12	on	on	IN
cord-309871-y17puao2	35	13	viral	viral	JJ
cord-309871-y17puao2	35	14	replication	replication	NN
cord-309871-y17puao2	35	15	and	and	CC
cord-309871-y17puao2	35	16	the	the	DT
cord-309871-y17puao2	35	17	cardiotoxicity	cardiotoxicity	NN
cord-309871-y17puao2	35	18	risk	risk	NN
cord-309871-y17puao2	35	19	of	of	IN
cord-309871-y17puao2	35	20	QTc	QTc	NNP
cord-309871-y17puao2	35	21	interval	interval	NN
cord-309871-y17puao2	35	22	prolongation	prolongation	NN
cord-309871-y17puao2	35	23	attempted	attempt	VBD
cord-309871-y17puao2	35	24	to	to	TO
cord-309871-y17puao2	35	25	predict	predict	VB
cord-309871-y17puao2	35	26	the	the	DT
cord-309871-y17puao2	35	27	highest	high	JJS
cord-309871-y17puao2	35	28	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	35	29	doses	dose	NNS
cord-309871-y17puao2	35	30	which	which	WDT
cord-309871-y17puao2	35	31	are	be	VBP
cord-309871-y17puao2	35	32	needed	need	VBN
cord-309871-y17puao2	35	33	to	to	TO
cord-309871-y17puao2	35	34	achieve	achieve	VB
cord-309871-y17puao2	35	35	both	both	DT
cord-309871-y17puao2	35	36	safety	safety	NN
cord-309871-y17puao2	35	37	and	and	CC
cord-309871-y17puao2	35	38	cure	cure	NN
cord-309871-y17puao2	35	39	within	within	IN
cord-309871-y17puao2	35	40	7	7	CD
cord-309871-y17puao2	35	41	days	day	NNS
cord-309871-y17puao2	35	42	(	(	-LRB-
cord-309871-y17puao2	35	43	22	22	CD
cord-309871-y17puao2	35	44	)	)	-RRB-
cord-309871-y17puao2	35	45	.	.	.
cord-309871-y17puao2	36	1	Why	why	WRB
cord-309871-y17puao2	36	2	could	could	MD
cord-309871-y17puao2	36	3	this	this	DT
cord-309871-y17puao2	36	4	couple	couple	NN
cord-309871-y17puao2	36	5	of	of	IN
cord-309871-y17puao2	36	6	antimalarial	antimalarial	JJ
cord-309871-y17puao2	36	7	and	and	CC
cord-309871-y17puao2	36	8	antibiotic	antibiotic	JJ
cord-309871-y17puao2	36	9	drugs	drug	NNS
cord-309871-y17puao2	36	10	be	be	VB
cord-309871-y17puao2	36	11	efficient	efficient	JJ
cord-309871-y17puao2	36	12	for	for	IN
cord-309871-y17puao2	36	13	such	such	PDT
cord-309871-y17puao2	36	14	a	a	DT
cord-309871-y17puao2	36	15	broad	broad	JJ
cord-309871-y17puao2	36	16	number	number	NN
cord-309871-y17puao2	36	17	of	of	IN
cord-309871-y17puao2	36	18	infectious	infectious	JJ
cord-309871-y17puao2	36	19	diseases	disease	NNS
cord-309871-y17puao2	36	20	caused	cause	VBN
cord-309871-y17puao2	36	21	by	by	IN
cord-309871-y17puao2	36	22	so	so	RB
cord-309871-y17puao2	36	23	various	various	JJ
cord-309871-y17puao2	36	24	pathogens	pathogen	NNS
cord-309871-y17puao2	36	25	such	such	JJ
cord-309871-y17puao2	36	26	as	as	IN
cord-309871-y17puao2	36	27	parasites	parasite	NNS
cord-309871-y17puao2	36	28	and	and	CC
cord-309871-y17puao2	36	29	intracellular	intracellular	JJ
cord-309871-y17puao2	36	30	bacteria	bacteria	NNS
cord-309871-y17puao2	36	31	or	or	CC
cord-309871-y17puao2	36	32	viruses	virus	NNS
cord-309871-y17puao2	36	33	?	?	.
cord-309871-y17puao2	37	1	That	that	DT
cord-309871-y17puao2	37	2	is	be	VBZ
cord-309871-y17puao2	37	3	the	the	DT
cord-309871-y17puao2	37	4	fundamental	fundamental	JJ
cord-309871-y17puao2	37	5	question	question	NN
cord-309871-y17puao2	37	6	.	.	.
cord-309871-y17puao2	38	1	Besides	besides	IN
cord-309871-y17puao2	38	2	their	-PRON-	PRP$
cord-309871-y17puao2	38	3	anti	anti	JJ
cord-309871-y17puao2	38	4	-	-	JJ
cord-309871-y17puao2	38	5	infectious	infectious	JJ
cord-309871-y17puao2	38	6	properties	property	NNS
cord-309871-y17puao2	38	7	,	,	,
cord-309871-y17puao2	38	8	the	the	DT
cord-309871-y17puao2	38	9	aminoquinoline	aminoquinoline	JJ
cord-309871-y17puao2	38	10	compounds	compound	NNS
cord-309871-y17puao2	38	11	are	be	VBP
cord-309871-y17puao2	38	12	immunomodulators	immunomodulator	NNS
cord-309871-y17puao2	38	13	that	that	WDT
cord-309871-y17puao2	38	14	could	could	MD
cord-309871-y17puao2	38	15	counteract	counteract	VB
cord-309871-y17puao2	38	16	the	the	DT
cord-309871-y17puao2	38	17	cytokine	cytokine	NN
cord-309871-y17puao2	38	18	storm	storm	NN
cord-309871-y17puao2	38	19	observed	observe	VBD
cord-309871-y17puao2	38	20	in	in	IN
cord-309871-y17puao2	38	21	the	the	DT
cord-309871-y17puao2	38	22	severe	severe	JJ
cord-309871-y17puao2	38	23	form	form	NN
cord-309871-y17puao2	38	24	of	of	IN
cord-309871-y17puao2	38	25	COVID-19	COVID-19	NNP
cord-309871-y17puao2	38	26	(	(	-LRB-
cord-309871-y17puao2	38	27	4	4	CD
cord-309871-y17puao2	38	28	,	,	,
cord-309871-y17puao2	38	29	9	9	CD
cord-309871-y17puao2	38	30	,	,	,
cord-309871-y17puao2	38	31	16	16	CD
cord-309871-y17puao2	38	32	)	)	-RRB-
cord-309871-y17puao2	38	33	.	.	.
cord-309871-y17puao2	39	1	Also	also	RB
cord-309871-y17puao2	39	2	,	,	,
cord-309871-y17puao2	39	3	they	-PRON-	PRP
cord-309871-y17puao2	39	4	are	be	VBP
cord-309871-y17puao2	39	5	known	know	VBN
cord-309871-y17puao2	39	6	to	to	TO
cord-309871-y17puao2	39	7	stop	stop	VB
cord-309871-y17puao2	39	8	virus	virus	NN
cord-309871-y17puao2	39	9	replication	replication	NN
cord-309871-y17puao2	39	10	as	as	IN
cord-309871-y17puao2	39	11	in	in	IN
cord-309871-y17puao2	39	12	most	most	JJS
cord-309871-y17puao2	39	13	of	of	IN
cord-309871-y17puao2	39	14	the	the	DT
cord-309871-y17puao2	39	15	clinical	clinical	JJ
cord-309871-y17puao2	39	16	trials	trial	NNS
cord-309871-y17puao2	39	17	with	with	IN
cord-309871-y17puao2	39	18	both	both	DT
cord-309871-y17puao2	39	19	aminoquinolines	aminoquinoline	NNS
cord-309871-y17puao2	39	20	;	;	:
cord-309871-y17puao2	39	21	the	the	DT
cord-309871-y17puao2	39	22	virus	virus	NN
cord-309871-y17puao2	39	23	load	load	NN
cord-309871-y17puao2	39	24	is	be	VBZ
cord-309871-y17puao2	39	25	considered	consider	VBN
cord-309871-y17puao2	39	26	as	as	IN
cord-309871-y17puao2	39	27	a	a	DT
cord-309871-y17puao2	39	28	critical	critical	JJ
cord-309871-y17puao2	39	29	biomarker	biomarker	NN
cord-309871-y17puao2	39	30	endpoint	endpoint	NN
cord-309871-y17puao2	39	31	(	(	-LRB-
cord-309871-y17puao2	39	32	16	16	CD
cord-309871-y17puao2	39	33	)	)	-RRB-
cord-309871-y17puao2	39	34	.	.	.
cord-309871-y17puao2	40	1	This	this	DT
cord-309871-y17puao2	40	2	direct	direct	JJ
cord-309871-y17puao2	40	3	effect	effect	NN
cord-309871-y17puao2	40	4	on	on	IN
cord-309871-y17puao2	40	5	virus	virus	NN
cord-309871-y17puao2	40	6	replication	replication	NN
cord-309871-y17puao2	40	7	seems	seem	VBZ
cord-309871-y17puao2	40	8	to	to	TO
cord-309871-y17puao2	40	9	be	be	VB
cord-309871-y17puao2	40	10	dependent	dependent	JJ
cord-309871-y17puao2	40	11	on	on	IN
cord-309871-y17puao2	40	12	the	the	DT
cord-309871-y17puao2	40	13	fact	fact	NN
cord-309871-y17puao2	40	14	that	that	IN
cord-309871-y17puao2	40	15	these	these	DT
cord-309871-y17puao2	40	16	drugs	drug	NNS
cord-309871-y17puao2	40	17	and	and	CC
cord-309871-y17puao2	40	18	viruses	virus	NNS
cord-309871-y17puao2	40	19	share	share	VBP
cord-309871-y17puao2	40	20	common	common	JJ
cord-309871-y17puao2	40	21	sub	sub	JJ
cord-309871-y17puao2	40	22	-	-	JJ
cord-309871-y17puao2	40	23	cellular	cellular	JJ
cord-309871-y17puao2	40	24	organelles	organelle	NNS
cord-309871-y17puao2	40	25	trafficking	traffic	VBG
cord-309871-y17puao2	40	26	routes	route	NNS
cord-309871-y17puao2	40	27	involving	involve	VBG
cord-309871-y17puao2	40	28	either	either	CC
cord-309871-y17puao2	40	29	the	the	DT
cord-309871-y17puao2	40	30	trans	trans	NNP
cord-309871-y17puao2	40	31	-	-	NNP
cord-309871-y17puao2	40	32	Golgi	Golgi	NNP
cord-309871-y17puao2	40	33	secretory	secretory	JJ
cord-309871-y17puao2	40	34	pathway	pathway	NN
cord-309871-y17puao2	40	35	or	or	CC
cord-309871-y17puao2	40	36	the	the	DT
cord-309871-y17puao2	40	37	endosomal	endosomal	NNP
cord-309871-y17puao2	40	38	/	/	SYM
cord-309871-y17puao2	40	39	lysosomal	lysosomal	JJ
cord-309871-y17puao2	40	40	endocytotic	endocytotic	JJ
cord-309871-y17puao2	40	41	pathway	pathway	NN
cord-309871-y17puao2	40	42	.	.	.
cord-309871-y17puao2	41	1	On	on	IN
cord-309871-y17puao2	41	2	the	the	DT
cord-309871-y17puao2	41	3	one	one	CD
cord-309871-y17puao2	41	4	hand	hand	NN
cord-309871-y17puao2	41	5	,	,	,
cord-309871-y17puao2	41	6	the	the	DT
cord-309871-y17puao2	41	7	virus	virus	NN
cord-309871-y17puao2	41	8	uses	use	VBZ
cord-309871-y17puao2	41	9	endosome	endosome	NN
cord-309871-y17puao2	41	10	formation	formation	NN
cord-309871-y17puao2	41	11	as	as	IN
cord-309871-y17puao2	41	12	a	a	DT
cord-309871-y17puao2	41	13	cellular	cellular	JJ
cord-309871-y17puao2	41	14	entry	entry	NN
cord-309871-y17puao2	41	15	mechanism	mechanism	NN
cord-309871-y17puao2	41	16	.	.	.
cord-309871-y17puao2	42	1	Thus	thus	RB
cord-309871-y17puao2	42	2	,	,	,
cord-309871-y17puao2	42	3	following	follow	VBG
cord-309871-y17puao2	42	4	the	the	DT
cord-309871-y17puao2	42	5	binding	binding	NN
cord-309871-y17puao2	42	6	of	of	IN
cord-309871-y17puao2	42	7	the	the	DT
cord-309871-y17puao2	42	8	CoV-2	CoV-2	NNP
cord-309871-y17puao2	42	9	spike	spike	NN
cord-309871-y17puao2	42	10	protein	protein	NN
cord-309871-y17puao2	42	11	to	to	IN
cord-309871-y17puao2	42	12	the	the	DT
cord-309871-y17puao2	42	13	angiotensin	angiotensin	NN
cord-309871-y17puao2	42	14	-	-	HYPH
cord-309871-y17puao2	42	15	converting	convert	VBG
cord-309871-y17puao2	42	16	enzyme	enzyme	NN
cord-309871-y17puao2	42	17	2	2	CD
cord-309871-y17puao2	43	1	(	(	-LRB-
cord-309871-y17puao2	43	2	ACE2	ACE2	NNP
cord-309871-y17puao2	43	3	)	)	-RRB-
cord-309871-y17puao2	43	4	virus	virus	NN
cord-309871-y17puao2	43	5	-	-	HYPH
cord-309871-y17puao2	43	6	receptor	receptor	NN
cord-309871-y17puao2	43	7	,	,	,
cord-309871-y17puao2	43	8	SARS	SARS	NNP
cord-309871-y17puao2	43	9	-	-	HYPH
cord-309871-y17puao2	43	10	CoV-2	CoV-2	NNP
cord-309871-y17puao2	43	11	travels	travel	VBZ
cord-309871-y17puao2	43	12	inside	inside	IN
cord-309871-y17puao2	43	13	the	the	DT
cord-309871-y17puao2	43	14	vesicular	vesicular	JJ
cord-309871-y17puao2	43	15	network	network	NN
cord-309871-y17puao2	43	16	including	include	VBG
cord-309871-y17puao2	43	17	endosomes	endosome	NNS
cord-309871-y17puao2	43	18	and	and	CC
cord-309871-y17puao2	43	19	lysosomes	lysosome	NNS
cord-309871-y17puao2	43	20	.	.	.
cord-309871-y17puao2	44	1	On	on	IN
cord-309871-y17puao2	44	2	the	the	DT
cord-309871-y17puao2	44	3	other	other	JJ
cord-309871-y17puao2	44	4	hand	hand	NN
cord-309871-y17puao2	44	5	,	,	,
cord-309871-y17puao2	44	6	several	several	JJ
cord-309871-y17puao2	44	7	processes	process	NNS
cord-309871-y17puao2	44	8	occur	occur	VBP
cord-309871-y17puao2	44	9	within	within	IN
cord-309871-y17puao2	44	10	the	the	DT
cord-309871-y17puao2	44	11	organellar	organellar	NNP
cord-309871-y17puao2	44	12	lumen	lumen	NNP
cord-309871-y17puao2	44	13	,	,	,
cord-309871-y17puao2	44	14	like	like	IN
cord-309871-y17puao2	44	15	the	the	DT
cord-309871-y17puao2	44	16	glycosylation	glycosylation	NN
cord-309871-y17puao2	44	17	of	of	IN
cord-309871-y17puao2	44	18	CoV-2	CoV-2	NNP
cord-309871-y17puao2	44	19	proteins	protein	NNS
cord-309871-y17puao2	44	20	during	during	IN
cord-309871-y17puao2	44	21	their	-PRON-	PRP$
cord-309871-y17puao2	44	22	biogenesis	biogenesis	NN
cord-309871-y17puao2	44	23	and	and	CC
cord-309871-y17puao2	44	24	assembly	assembly	NN
cord-309871-y17puao2	44	25	as	as	RB
cord-309871-y17puao2	44	26	well	well	RB
cord-309871-y17puao2	44	27	as	as	IN
cord-309871-y17puao2	44	28	the	the	DT
cord-309871-y17puao2	44	29	action	action	NN
cord-309871-y17puao2	44	30	of	of	IN
cord-309871-y17puao2	44	31	several	several	JJ
cord-309871-y17puao2	44	32	endosomal	endosomal	NNP
cord-309871-y17puao2	44	33	proteases	protease	NNS
cord-309871-y17puao2	44	34	able	able	JJ
cord-309871-y17puao2	44	35	to	to	TO
cord-309871-y17puao2	44	36	cleave	cleave	VB
cord-309871-y17puao2	44	37	CoV-2	CoV-2	NNP
cord-309871-y17puao2	44	38	spike	spike	NN
cord-309871-y17puao2	44	39	proteins	protein	NNS
cord-309871-y17puao2	44	40	for	for	IN
cord-309871-y17puao2	44	41	virus	virus	NN
cord-309871-y17puao2	44	42	entry	entry	NN
cord-309871-y17puao2	44	43	(	(	-LRB-
cord-309871-y17puao2	44	44	4	4	CD
cord-309871-y17puao2	44	45	,	,	,
cord-309871-y17puao2	44	46	9	9	CD
cord-309871-y17puao2	44	47	,	,	,
cord-309871-y17puao2	44	48	16	16	CD
cord-309871-y17puao2	44	49	,	,	,
cord-309871-y17puao2	44	50	20	20	CD
cord-309871-y17puao2	44	51	)	)	-RRB-
cord-309871-y17puao2	44	52	.	.	.
cord-309871-y17puao2	45	1	Therefore	therefore	RB
cord-309871-y17puao2	45	2	,	,	,
cord-309871-y17puao2	45	3	all	all	PDT
cord-309871-y17puao2	45	4	these	these	DT
cord-309871-y17puao2	45	5	life	life	NN
cord-309871-y17puao2	45	6	-	-	HYPH
cord-309871-y17puao2	45	7	virus	virus	NN
cord-309871-y17puao2	45	8	steps	step	NNS
cord-309871-y17puao2	45	9	are	be	VBP
cord-309871-y17puao2	45	10	dependent	dependent	JJ
cord-309871-y17puao2	45	11	on	on	IN
cord-309871-y17puao2	45	12	the	the	DT
cord-309871-y17puao2	45	13	remarkable	remarkable	JJ
cord-309871-y17puao2	45	14	intra	intra	JJ
cord-309871-y17puao2	45	15	-	-	JJ
cord-309871-y17puao2	45	16	organelle	organelle	JJ
cord-309871-y17puao2	45	17	acidic	acidic	JJ
cord-309871-y17puao2	45	18	conditions	condition	NNS
cord-309871-y17puao2	45	19	,	,	,
cord-309871-y17puao2	45	20	with	with	IN
cord-309871-y17puao2	45	21	pH	ph	NN
cord-309871-y17puao2	45	22	around	around	IN
cord-309871-y17puao2	45	23	4	4	CD
cord-309871-y17puao2	45	24	-	-	SYM
cord-309871-y17puao2	45	25	5	5	CD
cord-309871-y17puao2	45	26	.	.	.
cord-309871-y17puao2	46	1	A	a	DT
cord-309871-y17puao2	46	2	vacuolar	vacuolar	JJ
cord-309871-y17puao2	46	3	-	-	HYPH
cord-309871-y17puao2	46	4	type	type	NN
cord-309871-y17puao2	46	5	proton	proton	NN
cord-309871-y17puao2	46	6	adenosine	adenosine	NN
cord-309871-y17puao2	46	7	triphosphatase	triphosphatase	NN
cord-309871-y17puao2	46	8	membrane	membrane	NN
cord-309871-y17puao2	46	9	(	(	-LRB-
cord-309871-y17puao2	46	10	v	v	NN
cord-309871-y17puao2	46	11	-	-	:
cord-309871-y17puao2	46	12	ATPase	ATPase	NNP
cord-309871-y17puao2	46	13	)	)	-RRB-
cord-309871-y17puao2	46	14	,	,	,
cord-309871-y17puao2	46	15	pumping	pump	VBG
cord-309871-y17puao2	46	16	protons	proton	NNS
cord-309871-y17puao2	46	17	towards	towards	IN
cord-309871-y17puao2	46	18	the	the	DT
cord-309871-y17puao2	46	19	vesicle	vesicle	NN
cord-309871-y17puao2	46	20	interior	interior	NN
cord-309871-y17puao2	46	21	,	,	,
cord-309871-y17puao2	46	22	contributes	contribute	VBZ
cord-309871-y17puao2	46	23	to	to	TO
cord-309871-y17puao2	46	24	maintain	maintain	VB
cord-309871-y17puao2	46	25	this	this	DT
cord-309871-y17puao2	46	26	optimal	optimal	JJ
cord-309871-y17puao2	46	27	pH	ph	NN
cord-309871-y17puao2	46	28	medium	medium	NN
cord-309871-y17puao2	46	29	for	for	IN
cord-309871-y17puao2	46	30	nearly	nearly	RB
cord-309871-y17puao2	46	31	60	60	CD
cord-309871-y17puao2	46	32	different	different	JJ
cord-309871-y17puao2	46	33	hydrolytic	hydrolytic	JJ
cord-309871-y17puao2	46	34	lysosomal	lysosomal	JJ
cord-309871-y17puao2	46	35	enzymes	enzyme	NNS
cord-309871-y17puao2	46	36	,	,	,
cord-309871-y17puao2	46	37	such	such	JJ
cord-309871-y17puao2	46	38	as	as	IN
cord-309871-y17puao2	46	39	some	some	DT
cord-309871-y17puao2	46	40	acid	acid	NN
cord-309871-y17puao2	46	41	proteases	protease	NNS
cord-309871-y17puao2	46	42	which	which	WDT
cord-309871-y17puao2	46	43	are	be	VBP
cord-309871-y17puao2	46	44	implicated	implicate	VBN
cord-309871-y17puao2	46	45	in	in	IN
cord-309871-y17puao2	46	46	the	the	DT
cord-309871-y17puao2	46	47	virus	virus	NN
cord-309871-y17puao2	46	48	replication	replication	NN
cord-309871-y17puao2	46	49	cycle	cycle	NN
cord-309871-y17puao2	46	50	(	(	-LRB-
cord-309871-y17puao2	46	51	23	23	CD
cord-309871-y17puao2	46	52	)	)	-RRB-
cord-309871-y17puao2	46	53	(	(	-LRB-
cord-309871-y17puao2	46	54	Fig	Fig	NNP
cord-309871-y17puao2	46	55	.	.	NNP
cord-309871-y17puao2	46	56	1	1	CD
cord-309871-y17puao2	46	57	)	)	-RRB-
cord-309871-y17puao2	46	58	.	.	.
cord-309871-y17puao2	47	1	In	in	IN
cord-309871-y17puao2	47	2	fact	fact	NN
cord-309871-y17puao2	47	3	,	,	,
cord-309871-y17puao2	47	4	viruses	virus	NNS
cord-309871-y17puao2	47	5	and	and	CC
cord-309871-y17puao2	47	6	drugs	drug	NNS
cord-309871-y17puao2	47	7	together	together	RB
cord-309871-y17puao2	47	8	meet	meet	VBP
cord-309871-y17puao2	47	9	in	in	IN
cord-309871-y17puao2	47	10	this	this	DT
cord-309871-y17puao2	47	11	common	common	JJ
cord-309871-y17puao2	47	12	biophase	biophase	NN
cord-309871-y17puao2	47	13	of	of	IN
cord-309871-y17puao2	47	14	these	these	DT
cord-309871-y17puao2	47	15	sub	sub	JJ
cord-309871-y17puao2	47	16	-	-	JJ
cord-309871-y17puao2	47	17	cellular	cellular	JJ
cord-309871-y17puao2	47	18	organelles	organelle	NNS
cord-309871-y17puao2	47	19	during	during	IN
cord-309871-y17puao2	47	20	their	-PRON-	PRP$
cord-309871-y17puao2	47	21	respective	respective	JJ
cord-309871-y17puao2	47	22	time	time	NN
cord-309871-y17puao2	47	23	-	-	HYPH
cord-309871-y17puao2	47	24	dependent	dependent	JJ
cord-309871-y17puao2	47	25	distribution	distribution	NN
cord-309871-y17puao2	47	26	.	.	.
cord-309871-y17puao2	48	1	These	these	DT
cord-309871-y17puao2	48	2	drugs	drug	NNS
cord-309871-y17puao2	48	3	share	share	VBP
cord-309871-y17puao2	48	4	similar	similar	JJ
cord-309871-y17puao2	48	5	pharmacokinetic	pharmacokinetic	JJ
cord-309871-y17puao2	48	6	profiles	profile	NNS
cord-309871-y17puao2	48	7	with	with	IN
cord-309871-y17puao2	48	8	extensive	extensive	JJ
cord-309871-y17puao2	48	9	tissue	tissue	NN
cord-309871-y17puao2	48	10	distributions	distribution	NNS
cord-309871-y17puao2	48	11	characterized	characterize	VBN
cord-309871-y17puao2	48	12	by	by	IN
cord-309871-y17puao2	48	13	elevated	elevated	JJ
cord-309871-y17puao2	48	14	volumes	volume	NNS
cord-309871-y17puao2	48	15	of	of	IN
cord-309871-y17puao2	48	16	distribution	distribution	NN
cord-309871-y17puao2	48	17	,	,	,
cord-309871-y17puao2	48	18	moderate	moderate	JJ
cord-309871-y17puao2	48	19	plasma	plasma	NN
cord-309871-y17puao2	48	20	protein	protein	NN
cord-309871-y17puao2	48	21	binding	binding	NN
cord-309871-y17puao2	48	22	,	,	,
cord-309871-y17puao2	48	23	and	and	CC
cord-309871-y17puao2	48	24	high	high	JJ
cord-309871-y17puao2	48	25	intracellular	intracellular	JJ
cord-309871-y17puao2	48	26	distribution	distribution	NN
cord-309871-y17puao2	48	27	with	with	IN
cord-309871-y17puao2	48	28	tropism	tropism	NN
cord-309871-y17puao2	48	29	for	for	IN
cord-309871-y17puao2	48	30	lysosome	lysosome	NN
cord-309871-y17puao2	48	31	-	-	HYPH
cord-309871-y17puao2	48	32	rich	rich	JJ
cord-309871-y17puao2	48	33	organs	organ	NNS
cord-309871-y17puao2	48	34	,	,	,
cord-309871-y17puao2	48	35	such	such	JJ
cord-309871-y17puao2	48	36	as	as	IN
cord-309871-y17puao2	48	37	liver	liver	NN
cord-309871-y17puao2	48	38	and	and	CC
cord-309871-y17puao2	48	39	lung	lung	NN
cord-309871-y17puao2	48	40	.	.	.
cord-309871-y17puao2	49	1	They	-PRON-	PRP
cord-309871-y17puao2	49	2	also	also	RB
cord-309871-y17puao2	49	3	exhibit	exhibit	VBP
cord-309871-y17puao2	49	4	low	low	JJ
cord-309871-y17puao2	49	5	total	total	JJ
cord-309871-y17puao2	49	6	body	body	NN
cord-309871-y17puao2	49	7	clearances	clearance	NNS
cord-309871-y17puao2	49	8	which	which	WDT
cord-309871-y17puao2	49	9	contribute	contribute	VBP
cord-309871-y17puao2	49	10	to	to	IN
cord-309871-y17puao2	49	11	long	long	JJ
cord-309871-y17puao2	49	12	body	body	NN
cord-309871-y17puao2	49	13	exposure	exposure	NN
cord-309871-y17puao2	49	14	(	(	-LRB-
cord-309871-y17puao2	49	15	24	24	CD
cord-309871-y17puao2	49	16	)	)	-RRB-
cord-309871-y17puao2	49	17	(	(	-LRB-
cord-309871-y17puao2	49	18	25	25	CD
cord-309871-y17puao2	49	19	)	)	-RRB-
cord-309871-y17puao2	49	20	(	(	-LRB-
cord-309871-y17puao2	49	21	26	26	CD
cord-309871-y17puao2	49	22	)	)	-RRB-
cord-309871-y17puao2	49	23	.	.	.
cord-309871-y17puao2	50	1	More	more	RBR
cord-309871-y17puao2	50	2	interestingly	interestingly	RB
cord-309871-y17puao2	50	3	,	,	,
cord-309871-y17puao2	50	4	chloroquine	chloroquine	NN
cord-309871-y17puao2	50	5	,	,	,
cord-309871-y17puao2	50	6	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	50	7	,	,	,
cord-309871-y17puao2	50	8	and	and	CC
cord-309871-y17puao2	50	9	azithromycin	azithromycin	NNP
cord-309871-y17puao2	50	10	have	have	VBP
cord-309871-y17puao2	50	11	also	also	RB
cord-309871-y17puao2	50	12	been	be	VBN
cord-309871-y17puao2	50	13	described	describe	VBN
cord-309871-y17puao2	50	14	as	as	IN
cord-309871-y17puao2	50	15	potent	potent	JJ
cord-309871-y17puao2	50	16	lysosomotropic	lysosomotropic	JJ
cord-309871-y17puao2	50	17	compounds	compound	NNS
cord-309871-y17puao2	50	18	as	as	IN
cord-309871-y17puao2	50	19	they	-PRON-	PRP
cord-309871-y17puao2	50	20	are	be	VBP
cord-309871-y17puao2	50	21	diprotic	diprotic	JJ
cord-309871-y17puao2	50	22	weak	weak	JJ
cord-309871-y17puao2	50	23	bases	basis	NNS
cord-309871-y17puao2	50	24	with	with	IN
cord-309871-y17puao2	50	25	pKa	pKa	NNP
cord-309871-y17puao2	50	26	at	at	IN
cord-309871-y17puao2	50	27	8.38	8.38	CD
cord-309871-y17puao2	50	28	-	-	HYPH
cord-309871-y17puao2	50	29	10.18	10.18	CD
cord-309871-y17puao2	50	30	,	,	,
cord-309871-y17puao2	50	31	8.27	8.27	CD
cord-309871-y17puao2	50	32	-	-	HYPH
cord-309871-y17puao2	50	33	9.67	9.67	CD
cord-309871-y17puao2	50	34	,	,	,
cord-309871-y17puao2	50	35	and	and	CC
cord-309871-y17puao2	50	36	8.74	8.74	CD
cord-309871-y17puao2	50	37	-	-	HYPH
cord-309871-y17puao2	50	38	9.45	9.45	CD
cord-309871-y17puao2	50	39	,	,	,
cord-309871-y17puao2	50	40	respectively	respectively	RB
cord-309871-y17puao2	50	41	(	(	-LRB-
cord-309871-y17puao2	50	42	4	4	CD
cord-309871-y17puao2	50	43	,	,	,
cord-309871-y17puao2	50	44	9	9	CD
cord-309871-y17puao2	50	45	,	,	,
cord-309871-y17puao2	50	46	27	27	CD
cord-309871-y17puao2	50	47	)	)	-RRB-
cord-309871-y17puao2	50	48	.	.	.
cord-309871-y17puao2	51	1	These	these	DT
cord-309871-y17puao2	51	2	physicochemical	physicochemical	JJ
cord-309871-y17puao2	51	3	criteria	criterion	NNS
cord-309871-y17puao2	51	4	associated	associate	VBN
cord-309871-y17puao2	51	5	with	with	IN
cord-309871-y17puao2	51	6	elevated	elevated	JJ
cord-309871-y17puao2	51	7	log	log	NN
cord-309871-y17puao2	51	8	P	p	NN
cord-309871-y17puao2	51	9	,	,	,
cord-309871-y17puao2	51	10	ranged	range	VBD
cord-309871-y17puao2	51	11	from	from	IN
cord-309871-y17puao2	51	12	3.6	3.6	CD
cord-309871-y17puao2	51	13	to	to	IN
cord-309871-y17puao2	51	14	4.6	4.6	CD
cord-309871-y17puao2	51	15	,	,	,
cord-309871-y17puao2	51	16	meet	meet	VB
cord-309871-y17puao2	51	17	those	those	DT
cord-309871-y17puao2	51	18	defining	define	VBG
cord-309871-y17puao2	51	19	a	a	DT
cord-309871-y17puao2	51	20	subgroup	subgroup	NN
cord-309871-y17puao2	51	21	of	of	IN
cord-309871-y17puao2	51	22	lysosomotropic	lysosomotropic	JJ
cord-309871-y17puao2	51	23	amines	amine	NNS
cord-309871-y17puao2	51	24	,	,	,
cord-309871-y17puao2	51	25	known	know	VBN
cord-309871-y17puao2	51	26	as	as	IN
cord-309871-y17puao2	51	27	cationic	cationic	JJ
cord-309871-y17puao2	51	28	amphiphilic	amphiphilic	JJ
cord-309871-y17puao2	51	29	drugs	drug	NNS
cord-309871-y17puao2	51	30	(	(	-LRB-
cord-309871-y17puao2	51	31	28	28	CD
cord-309871-y17puao2	51	32	)	)	-RRB-
cord-309871-y17puao2	51	33	.	.	.
cord-309871-y17puao2	52	1	Thus	thus	RB
cord-309871-y17puao2	52	2	,	,	,
cord-309871-y17puao2	52	3	they	-PRON-	PRP
cord-309871-y17puao2	52	4	will	will	MD
cord-309871-y17puao2	52	5	become	become	VB
cord-309871-y17puao2	52	6	protonated	protonated	JJ
cord-309871-y17puao2	52	7	and	and	CC
cord-309871-y17puao2	52	8	trapped	trap	VBN
cord-309871-y17puao2	52	9	within	within	IN
cord-309871-y17puao2	52	10	the	the	DT
cord-309871-y17puao2	52	11	endosomal	endosomal	NNP
cord-309871-y17puao2	52	12	vesicles	vesicle	NNS
cord-309871-y17puao2	52	13	under	under	IN
cord-309871-y17puao2	52	14	these	these	DT
cord-309871-y17puao2	52	15	acidic	acidic	JJ
cord-309871-y17puao2	52	16	conditions	condition	NNS
cord-309871-y17puao2	52	17	and	and	CC
cord-309871-y17puao2	52	18	their	-PRON-	PRP$
cord-309871-y17puao2	52	19	backward	backward	JJ
cord-309871-y17puao2	52	20	diffusion	diffusion	NN
cord-309871-y17puao2	52	21	into	into	IN
cord-309871-y17puao2	52	22	the	the	DT
cord-309871-y17puao2	52	23	cytosol	cytosol	NN
cord-309871-y17puao2	52	24	was	be	VBD
cord-309871-y17puao2	52	25	hindered	hinder	VBN
cord-309871-y17puao2	52	26	(	(	-LRB-
cord-309871-y17puao2	52	27	29	29	CD
cord-309871-y17puao2	52	28	,	,	,
cord-309871-y17puao2	52	29	30	30	CD
cord-309871-y17puao2	52	30	)	)	-RRB-
cord-309871-y17puao2	52	31	.	.	.
cord-309871-y17puao2	53	1	Consequently	consequently	RB
cord-309871-y17puao2	53	2	,	,	,
cord-309871-y17puao2	53	3	their	-PRON-	PRP$
cord-309871-y17puao2	53	4	intravesicular	intravesicular	JJ
cord-309871-y17puao2	53	5	concentrations	concentration	NNS
cord-309871-y17puao2	53	6	can	can	MD
cord-309871-y17puao2	53	7	reach	reach	VB
cord-309871-y17puao2	53	8	hundredfold	hundredfold	JJ
cord-309871-y17puao2	53	9	that	that	DT
cord-309871-y17puao2	53	10	of	of	IN
cord-309871-y17puao2	53	11	the	the	DT
cord-309871-y17puao2	53	12	cytosolic	cytosolic	JJ
cord-309871-y17puao2	53	13	concentrations	concentration	NNS
cord-309871-y17puao2	53	14	and	and	CC
cord-309871-y17puao2	53	15	attain	attain	VB
cord-309871-y17puao2	53	16	or	or	CC
cord-309871-y17puao2	53	17	even	even	RB
cord-309871-y17puao2	53	18	surpass	surpass	VB
cord-309871-y17puao2	53	19	the	the	DT
cord-309871-y17puao2	53	20	low	low	JJ
cord-309871-y17puao2	53	21	micromolar	micromolar	JJ
cord-309871-y17puao2	53	22	effective	effective	JJ
cord-309871-y17puao2	53	23	concentrations	concentration	NNS
cord-309871-y17puao2	53	24	that	that	WDT
cord-309871-y17puao2	53	25	are	be	VBP
cord-309871-y17puao2	53	26	able	able	JJ
cord-309871-y17puao2	53	27	to	to	TO
cord-309871-y17puao2	53	28	inhibit	inhibit	VB
cord-309871-y17puao2	53	29	SARS	SARS	NNP
cord-309871-y17puao2	53	30	-	-	HYPH
cord-309871-y17puao2	53	31	CoV-2	CoV-2	NNP
cord-309871-y17puao2	53	32	virus	virus	NN
cord-309871-y17puao2	53	33	cycle	cycle	NN
cord-309871-y17puao2	53	34	(	(	-LRB-
cord-309871-y17puao2	53	35	8	8	CD
cord-309871-y17puao2	53	36	,	,	,
cord-309871-y17puao2	53	37	19	19	CD
cord-309871-y17puao2	53	38	,	,	,
cord-309871-y17puao2	53	39	21	21	CD
cord-309871-y17puao2	53	40	)	)	-RRB-
cord-309871-y17puao2	53	41	.	.	.
cord-309871-y17puao2	54	1	Concomitantly	concomitantly	RB
cord-309871-y17puao2	54	2	,	,	,
cord-309871-y17puao2	54	3	the	the	DT
cord-309871-y17puao2	54	4	drug	drug	NN
cord-309871-y17puao2	54	5	-	-	HYPH
cord-309871-y17puao2	54	6	induced	induce	VBN
cord-309871-y17puao2	54	7	lysosomotropic	lysosomotropic	JJ
cord-309871-y17puao2	54	8	effect	effect	NN
cord-309871-y17puao2	54	9	is	be	VBZ
cord-309871-y17puao2	54	10	completed	complete	VBN
cord-309871-y17puao2	54	11	by	by	IN
cord-309871-y17puao2	54	12	buffering	buffer	VBG
cord-309871-y17puao2	54	13	the	the	DT
cord-309871-y17puao2	54	14	intravesicular	intravesicular	JJ
cord-309871-y17puao2	54	15	acidity	acidity	NN
cord-309871-y17puao2	54	16	with	with	IN
cord-309871-y17puao2	54	17	pH	pH	NNP
cord-309871-y17puao2	54	18	increasing	increase	VBG
cord-309871-y17puao2	54	19	up	up	RP
cord-309871-y17puao2	54	20	to	to	IN
cord-309871-y17puao2	54	21	around	around	IN
cord-309871-y17puao2	54	22	neutrality	neutrality	NN
cord-309871-y17puao2	54	23	.	.	.
cord-309871-y17puao2	55	1	This	this	DT
cord-309871-y17puao2	55	2	last	last	JJ
cord-309871-y17puao2	55	3	effect	effect	NN
cord-309871-y17puao2	55	4	on	on	IN
cord-309871-y17puao2	55	5	the	the	DT
cord-309871-y17puao2	55	6	luminal	luminal	JJ
cord-309871-y17puao2	55	7	pH	ph	NN
cord-309871-y17puao2	55	8	is	be	VBZ
cord-309871-y17puao2	55	9	the	the	DT
cord-309871-y17puao2	55	10	most	most	RBS
cord-309871-y17puao2	55	11	critical	critical	JJ
cord-309871-y17puao2	55	12	on	on	IN
cord-309871-y17puao2	55	13	virus	virus	NN
cord-309871-y17puao2	55	14	development	development	NN
cord-309871-y17puao2	55	15	by	by	IN
cord-309871-y17puao2	55	16	decreasing	decrease	VBG
cord-309871-y17puao2	55	17	several	several	JJ
cord-309871-y17puao2	55	18	lysosomal	lysosomal	JJ
cord-309871-y17puao2	55	19	enzyme	enzyme	NN
cord-309871-y17puao2	55	20	activities	activity	NNS
cord-309871-y17puao2	55	21	responsible	responsible	JJ
cord-309871-y17puao2	55	22	for	for	IN
cord-309871-y17puao2	55	23	either	either	DT
cord-309871-y17puao2	55	24	glycosylation	glycosylation	NN
cord-309871-y17puao2	55	25	of	of	IN
cord-309871-y17puao2	55	26	both	both	CC
cord-309871-y17puao2	55	27	ACE2	ACE2	NNP
cord-309871-y17puao2	55	28	receptor	receptor	NN
cord-309871-y17puao2	55	29	and	and	CC
cord-309871-y17puao2	55	30	CoV-2	CoV-2	NNP
cord-309871-y17puao2	55	31	proteins	protein	NNS
cord-309871-y17puao2	55	32	or	or	CC
cord-309871-y17puao2	55	33	cleavage	cleavage	NN
cord-309871-y17puao2	55	34	of	of	IN
cord-309871-y17puao2	55	35	Cov-2	Cov-2	NNP
cord-309871-y17puao2	55	36	spike	spike	NN
cord-309871-y17puao2	55	37	proteins	protein	NNS
cord-309871-y17puao2	55	38	.	.	.
cord-309871-y17puao2	56	1	Presently	presently	RB
cord-309871-y17puao2	56	2	,	,	,
cord-309871-y17puao2	56	3	this	this	DT
cord-309871-y17puao2	56	4	intracellular	intracellular	JJ
cord-309871-y17puao2	56	5	trapping	trapping	NN
cord-309871-y17puao2	56	6	mechanism	mechanism	NN
cord-309871-y17puao2	56	7	is	be	VBZ
cord-309871-y17puao2	56	8	largely	largely	RB
cord-309871-y17puao2	56	9	reported	report	VBN
cord-309871-y17puao2	56	10	for	for	IN
cord-309871-y17puao2	56	11	sustaining	sustain	VBG
cord-309871-y17puao2	56	12	the	the	DT
cord-309871-y17puao2	56	13	additive	additive	NN
cord-309871-y17puao2	56	14	or	or	CC
cord-309871-y17puao2	56	15	synergistic	synergistic	JJ
cord-309871-y17puao2	56	16	effect	effect	NN
cord-309871-y17puao2	56	17	on	on	IN
cord-309871-y17puao2	56	18	various	various	JJ
cord-309871-y17puao2	56	19	pathogens	pathogen	NNS
cord-309871-y17puao2	56	20	following	follow	VBG
cord-309871-y17puao2	56	21	this	this	DT
cord-309871-y17puao2	56	22	drug	drug	NN
cord-309871-y17puao2	56	23	co	co	NN
cord-309871-y17puao2	56	24	-	-	NN
cord-309871-y17puao2	56	25	administration	administration	JJ
cord-309871-y17puao2	56	26	(	(	-LRB-
cord-309871-y17puao2	56	27	4	4	CD
cord-309871-y17puao2	56	28	,	,	,
cord-309871-y17puao2	56	29	9	9	CD
cord-309871-y17puao2	56	30	,	,	,
cord-309871-y17puao2	56	31	11	11	CD
cord-309871-y17puao2	56	32	)	)	-RRB-
cord-309871-y17puao2	56	33	.	.	.
cord-309871-y17puao2	57	1	Nevertheless	nevertheless	RB
cord-309871-y17puao2	57	2	,	,	,
cord-309871-y17puao2	57	3	I	-PRON-	PRP
cord-309871-y17puao2	57	4	believe	believe	VBP
cord-309871-y17puao2	57	5	that	that	IN
cord-309871-y17puao2	57	6	a	a	DT
cord-309871-y17puao2	57	7	supplementary	supplementary	JJ
cord-309871-y17puao2	57	8	mechanistic	mechanistic	JJ
cord-309871-y17puao2	57	9	explanation	explanation	NN
cord-309871-y17puao2	57	10	may	may	MD
cord-309871-y17puao2	57	11	be	be	VB
cord-309871-y17puao2	57	12	missing	miss	VBG
cord-309871-y17puao2	57	13	in	in	IN
cord-309871-y17puao2	57	14	the	the	DT
cord-309871-y17puao2	57	15	literature	literature	NN
cord-309871-y17puao2	57	16	for	for	IN
cord-309871-y17puao2	57	17	supporting	support	VBG
cord-309871-y17puao2	57	18	the	the	DT
cord-309871-y17puao2	57	19	additive	additive	NN
cord-309871-y17puao2	57	20	or	or	CC
cord-309871-y17puao2	57	21	synergistic	synergistic	JJ
cord-309871-y17puao2	57	22	interaction	interaction	NN
cord-309871-y17puao2	57	23	when	when	WRB
cord-309871-y17puao2	57	24	these	these	DT
cord-309871-y17puao2	57	25	drugs	drug	NNS
cord-309871-y17puao2	57	26	are	be	VBP
cord-309871-y17puao2	57	27	combined	combine	VBN
cord-309871-y17puao2	57	28	.	.	.
cord-309871-y17puao2	58	1	The	the	DT
cord-309871-y17puao2	58	2	first	first	JJ
cord-309871-y17puao2	58	3	reason	reason	NN
cord-309871-y17puao2	58	4	is	be	VBZ
cord-309871-y17puao2	58	5	that	that	IN
cord-309871-y17puao2	58	6	azithromycin	azithromycin	NNP
cord-309871-y17puao2	58	7	has	have	VBZ
cord-309871-y17puao2	58	8	been	be	VBN
cord-309871-y17puao2	58	9	shown	show	VBN
cord-309871-y17puao2	58	10	,	,	,
cord-309871-y17puao2	58	11	both	both	DT
cord-309871-y17puao2	58	12	in	in	IN
cord-309871-y17puao2	58	13	vitro	vitro	FW
cord-309871-y17puao2	58	14	and	and	CC
cord-309871-y17puao2	58	15	in	in	IN
cord-309871-y17puao2	58	16	vivo	vivo	NN
cord-309871-y17puao2	58	17	,	,	,
cord-309871-y17puao2	58	18	to	to	TO
cord-309871-y17puao2	58	19	be	be	VB
cord-309871-y17puao2	58	20	a	a	DT
cord-309871-y17puao2	58	21	substrate	substrate	NN
cord-309871-y17puao2	58	22	of	of	IN
cord-309871-y17puao2	58	23	ABCB1	abcb1	NN
cord-309871-y17puao2	58	24	(	(	-LRB-
cord-309871-y17puao2	58	25	P	p	NN
cord-309871-y17puao2	58	26	-	-	HYPH
cord-309871-y17puao2	58	27	glycoprotein	glycoprotein	NN
cord-309871-y17puao2	58	28	)	)	-RRB-
cord-309871-y17puao2	58	29	(	(	-LRB-
cord-309871-y17puao2	58	30	31	31	CD
cord-309871-y17puao2	58	31	)	)	-RRB-
cord-309871-y17puao2	58	32	(	(	-LRB-
cord-309871-y17puao2	58	33	32	32	CD
cord-309871-y17puao2	58	34	)	)	-RRB-
cord-309871-y17puao2	58	35	(	(	-LRB-
cord-309871-y17puao2	58	36	33	33	CD
cord-309871-y17puao2	58	37	)	)	-RRB-
cord-309871-y17puao2	58	38	(	(	-LRB-
cord-309871-y17puao2	58	39	34	34	CD
cord-309871-y17puao2	58	40	)	)	-RRB-
cord-309871-y17puao2	58	41	(	(	-LRB-
cord-309871-y17puao2	58	42	35	35	CD
cord-309871-y17puao2	58	43	)	)	-RRB-
cord-309871-y17puao2	58	44	(	(	-LRB-
cord-309871-y17puao2	58	45	36	36	CD
cord-309871-y17puao2	58	46	)	)	-RRB-
cord-309871-y17puao2	58	47	.	.	.
cord-309871-y17puao2	59	1	ABCB1	ABCB1	NNP
cord-309871-y17puao2	59	2	,	,	,
cord-309871-y17puao2	59	3	a	a	DT
cord-309871-y17puao2	59	4	member	member	NN
cord-309871-y17puao2	59	5	of	of	IN
cord-309871-y17puao2	59	6	the	the	DT
cord-309871-y17puao2	59	7	ATPbinding	atpbinde	VBG
cord-309871-y17puao2	59	8	cassette	cassette	NN
cord-309871-y17puao2	59	9	(	(	-LRB-
cord-309871-y17puao2	59	10	ABC	ABC	NNP
cord-309871-y17puao2	59	11	)	)	-RRB-
cord-309871-y17puao2	59	12	transporter	transporter	NN
cord-309871-y17puao2	59	13	superfamily	superfamily	NN
cord-309871-y17puao2	59	14	,	,	,
cord-309871-y17puao2	59	15	is	be	VBZ
cord-309871-y17puao2	59	16	mainly	mainly	RB
cord-309871-y17puao2	59	17	known	know	VBN
cord-309871-y17puao2	59	18	as	as	IN
cord-309871-y17puao2	59	19	being	be	VBG
cord-309871-y17puao2	59	20	expressed	express	VBN
cord-309871-y17puao2	59	21	on	on	IN
cord-309871-y17puao2	59	22	the	the	DT
cord-309871-y17puao2	59	23	cellular	cellular	JJ
cord-309871-y17puao2	59	24	plasma	plasma	NN
cord-309871-y17puao2	59	25	membrane	membrane	NN
cord-309871-y17puao2	59	26	in	in	IN
cord-309871-y17puao2	59	27	various	various	JJ
cord-309871-y17puao2	59	28	tissues	tissue	NNS
cord-309871-y17puao2	59	29	and	and	CC
cord-309871-y17puao2	59	30	can	can	MD
cord-309871-y17puao2	59	31	limit	limit	VB
cord-309871-y17puao2	59	32	the	the	DT
cord-309871-y17puao2	59	33	cellular	cellular	JJ
cord-309871-y17puao2	59	34	uptake	uptake	NN
cord-309871-y17puao2	59	35	of	of	IN
cord-309871-y17puao2	59	36	a	a	DT
cord-309871-y17puao2	59	37	large	large	JJ
cord-309871-y17puao2	59	38	number	number	NN
cord-309871-y17puao2	59	39	of	of	IN
cord-309871-y17puao2	59	40	drug	drug	NN
cord-309871-y17puao2	59	41	substrates	substrate	NNS
cord-309871-y17puao2	59	42	like	like	IN
cord-309871-y17puao2	59	43	azithromycin	azithromycin	NN
cord-309871-y17puao2	59	44	(	(	-LRB-
cord-309871-y17puao2	59	45	37	37	CD
cord-309871-y17puao2	59	46	)	)	-RRB-
cord-309871-y17puao2	59	47	.	.	.
cord-309871-y17puao2	60	1	A	a	DT
cord-309871-y17puao2	60	2	second	second	JJ
cord-309871-y17puao2	60	3	reason	reason	NN
cord-309871-y17puao2	60	4	is	be	VBZ
cord-309871-y17puao2	60	5	linked	link	VBN
cord-309871-y17puao2	60	6	to	to	IN
cord-309871-y17puao2	60	7	the	the	DT
cord-309871-y17puao2	60	8	ABCB1	ABCB1	NNP
cord-309871-y17puao2	60	9	localization	localization	NN
cord-309871-y17puao2	60	10	in	in	IN
cord-309871-y17puao2	60	11	intracellular	intracellular	JJ
cord-309871-y17puao2	60	12	compartments	compartment	NNS
cord-309871-y17puao2	60	13	,	,	,
cord-309871-y17puao2	60	14	such	such	JJ
cord-309871-y17puao2	60	15	as	as	IN
cord-309871-y17puao2	60	16	the	the	DT
cord-309871-y17puao2	60	17	endoplasmic	endoplasmic	NN
cord-309871-y17puao2	60	18	reticulum	reticulum	NN
cord-309871-y17puao2	60	19	and	and	CC
cord-309871-y17puao2	60	20	Golgi	Golgi	NNP
cord-309871-y17puao2	60	21	(	(	-LRB-
cord-309871-y17puao2	60	22	site	site	NN
cord-309871-y17puao2	60	23	of	of	IN
cord-309871-y17puao2	60	24	ABCB1	ABCB1	NNP
cord-309871-y17puao2	60	25	synthesis	synthesis	NN
cord-309871-y17puao2	60	26	)	)	-RRB-
cord-309871-y17puao2	60	27	,	,	,
cord-309871-y17puao2	60	28	the	the	DT
cord-309871-y17puao2	60	29	endosomes	endosome	NNS
cord-309871-y17puao2	60	30	for	for	IN
cord-309871-y17puao2	60	31	ABCB1	abcb1	NN
cord-309871-y17puao2	60	32	trafficking	trafficking	NN
cord-309871-y17puao2	60	33	and	and	CC
cord-309871-y17puao2	60	34	recycling	recycling	NN
cord-309871-y17puao2	60	35	,	,	,
cord-309871-y17puao2	60	36	and	and	CC
cord-309871-y17puao2	60	37	lysosomes	lysosome	NNS
cord-309871-y17puao2	60	38	for	for	IN
cord-309871-y17puao2	60	39	its	-PRON-	PRP$
cord-309871-y17puao2	60	40	degradation	degradation	NN
cord-309871-y17puao2	60	41	(	(	-LRB-
cord-309871-y17puao2	60	42	38	38	CD
cord-309871-y17puao2	60	43	,	,	,
cord-309871-y17puao2	60	44	39	39	CD
cord-309871-y17puao2	60	45	)	)	-RRB-
cord-309871-y17puao2	60	46	.	.	.
cord-309871-y17puao2	61	1	Finally	finally	RB
cord-309871-y17puao2	61	2	,	,	,
cord-309871-y17puao2	61	3	the	the	DT
cord-309871-y17puao2	61	4	ABCB1	ABCB1	NNP
cord-309871-y17puao2	61	5	substrate	substrate	NN
cord-309871-y17puao2	61	6	transport	transport	NN
cord-309871-y17puao2	61	7	direction	direction	NN
cord-309871-y17puao2	61	8	on	on	IN
cord-309871-y17puao2	61	9	endosome	endosome	NN
cord-309871-y17puao2	61	10	and	and	CC
cord-309871-y17puao2	61	11	lysosome	lysosome	NN
cord-309871-y17puao2	61	12	membranes	membrane	NNS
cord-309871-y17puao2	61	13	is	be	VBZ
cord-309871-y17puao2	61	14	a	a	DT
cord-309871-y17puao2	61	15	very	very	RB
cord-309871-y17puao2	61	16	critical	critical	JJ
cord-309871-y17puao2	61	17	property	property	NN
cord-309871-y17puao2	61	18	.	.	.
cord-309871-y17puao2	62	1	The	the	DT
cord-309871-y17puao2	62	2	polarized	polarized	JJ
cord-309871-y17puao2	62	3	transport	transport	NN
cord-309871-y17puao2	62	4	direction	direction	NN
cord-309871-y17puao2	62	5	occurs	occur	VBZ
cord-309871-y17puao2	62	6	from	from	IN
cord-309871-y17puao2	62	7	the	the	DT
cord-309871-y17puao2	62	8	cell	cell	NN
cord-309871-y17puao2	62	9	cytosol	cytosol	NN
cord-309871-y17puao2	62	10	,	,	,
cord-309871-y17puao2	62	11	where	where	WRB
cord-309871-y17puao2	62	12	the	the	DT
cord-309871-y17puao2	62	13	neutral	neutral	JJ
cord-309871-y17puao2	62	14	pH	pH	NNP
cord-309871-y17puao2	62	15	allows	allow	VBZ
cord-309871-y17puao2	62	16	the	the	DT
cord-309871-y17puao2	62	17	ATP	ATP	NNP
cord-309871-y17puao2	62	18	catalytic	catalytic	JJ
cord-309871-y17puao2	62	19	cycle	cycle	NN
cord-309871-y17puao2	62	20	of	of	IN
cord-309871-y17puao2	62	21	ABCB1	ABCB1	NNP
cord-309871-y17puao2	62	22	,	,	,
cord-309871-y17puao2	62	23	into	into	IN
cord-309871-y17puao2	62	24	the	the	DT
cord-309871-y17puao2	62	25	interior	interior	NN
cord-309871-y17puao2	62	26	of	of	IN
cord-309871-y17puao2	62	27	the	the	DT
cord-309871-y17puao2	62	28	vesicle	vesicle	NN
cord-309871-y17puao2	62	29	.	.	.
cord-309871-y17puao2	63	1	This	this	DT
cord-309871-y17puao2	63	2	transport	transport	NN
cord-309871-y17puao2	63	3	direction	direction	NN
cord-309871-y17puao2	63	4	is	be	VBZ
cord-309871-y17puao2	63	5	the	the	DT
cord-309871-y17puao2	63	6	opposite	opposite	NN
cord-309871-y17puao2	63	7	from	from	IN
cord-309871-y17puao2	63	8	that	that	DT
cord-309871-y17puao2	63	9	mediated	mediate	VBN
cord-309871-y17puao2	63	10	at	at	IN
cord-309871-y17puao2	63	11	the	the	DT
cord-309871-y17puao2	63	12	plasma	plasma	NN
cord-309871-y17puao2	63	13	membrane	membrane	NN
cord-309871-y17puao2	63	14	surface	surface	NN
cord-309871-y17puao2	63	15	(	(	-LRB-
cord-309871-y17puao2	63	16	Fig	Fig	NNP
cord-309871-y17puao2	63	17	.	.	.
cord-309871-y17puao2	63	18	1	1	CD
cord-309871-y17puao2	63	19	)	)	-RRB-
cord-309871-y17puao2	63	20	.	.	.
cord-309871-y17puao2	64	1	Based	base	VBN
cord-309871-y17puao2	64	2	on	on	IN
cord-309871-y17puao2	64	3	these	these	DT
cord-309871-y17puao2	64	4	overall	overall	JJ
cord-309871-y17puao2	64	5	information	information	NN
cord-309871-y17puao2	64	6	,	,	,
cord-309871-y17puao2	64	7	we	-PRON-	PRP
cord-309871-y17puao2	64	8	might	may	MD
cord-309871-y17puao2	64	9	hypothesize	hypothesize	VB
cord-309871-y17puao2	64	10	that	that	IN
cord-309871-y17puao2	64	11	ABCB1	ABCB1	NNP
cord-309871-y17puao2	64	12	could	could	MD
cord-309871-y17puao2	64	13	play	play	VB
cord-309871-y17puao2	64	14	a	a	DT
cord-309871-y17puao2	64	15	possible	possible	JJ
cord-309871-y17puao2	64	16	role	role	NN
cord-309871-y17puao2	64	17	for	for	IN
cord-309871-y17puao2	64	18	the	the	DT
cord-309871-y17puao2	64	19	additive	additive	NN
cord-309871-y17puao2	64	20	or	or	CC
cord-309871-y17puao2	64	21	most	most	RBS
cord-309871-y17puao2	64	22	likely	likely	JJ
cord-309871-y17puao2	64	23	,	,	,
cord-309871-y17puao2	64	24	the	the	DT
cord-309871-y17puao2	64	25	synergistic	synergistic	JJ
cord-309871-y17puao2	64	26	effect	effect	NN
cord-309871-y17puao2	64	27	of	of	IN
cord-309871-y17puao2	64	28	azithromycin	azithromycin	NNP
cord-309871-y17puao2	64	29	on	on	IN
cord-309871-y17puao2	64	30	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	64	31	.	.	.
cord-309871-y17puao2	65	1	At	at	IN
cord-309871-y17puao2	65	2	this	this	DT
cord-309871-y17puao2	65	3	stage	stage	NN
cord-309871-y17puao2	65	4	,	,	,
cord-309871-y17puao2	65	5	the	the	DT
cord-309871-y17puao2	65	6	question	question	NN
cord-309871-y17puao2	65	7	on	on	IN
cord-309871-y17puao2	65	8	how	how	WRB
cord-309871-y17puao2	65	9	the	the	DT
cord-309871-y17puao2	65	10	ABCB1-dependent	ABCB1-dependent	NNP
cord-309871-y17puao2	65	11	synergy	synergy	NN
cord-309871-y17puao2	65	12	might	may	MD
cord-309871-y17puao2	65	13	occur	occur	VB
cord-309871-y17puao2	65	14	is	be	VBZ
cord-309871-y17puao2	65	15	still	still	RB
cord-309871-y17puao2	65	16	open	open	JJ
cord-309871-y17puao2	65	17	.	.	.
cord-309871-y17puao2	66	1	Based	base	VBN
cord-309871-y17puao2	66	2	on	on	IN
cord-309871-y17puao2	66	3	known	know	VBN
cord-309871-y17puao2	66	4	pharmacological	pharmacological	JJ
cord-309871-y17puao2	66	5	modulations	modulation	NNS
cord-309871-y17puao2	66	6	mediated	mediate	VBN
cord-309871-y17puao2	66	7	by	by	IN
cord-309871-y17puao2	66	8	ABCB1	ABCB1	NNP
cord-309871-y17puao2	66	9	,	,	,
cord-309871-y17puao2	66	10	we	-PRON-	PRP
cord-309871-y17puao2	66	11	could	could	MD
cord-309871-y17puao2	66	12	imagine	imagine	VB
cord-309871-y17puao2	66	13	two	two	CD
cord-309871-y17puao2	66	14	possible	possible	JJ
cord-309871-y17puao2	66	15	scenarios	scenario	NNS
cord-309871-y17puao2	66	16	.	.	.
cord-309871-y17puao2	67	1	The	the	DT
cord-309871-y17puao2	67	2	first	first	JJ
cord-309871-y17puao2	67	3	one	one	NN
cord-309871-y17puao2	67	4	is	be	VBZ
cord-309871-y17puao2	67	5	related	relate	VBN
cord-309871-y17puao2	67	6	to	to	IN
cord-309871-y17puao2	67	7	the	the	DT
cord-309871-y17puao2	67	8	inverted	inverted	JJ
cord-309871-y17puao2	67	9	influx	influx	JJ
cord-309871-y17puao2	67	10	transport	transport	NN
cord-309871-y17puao2	67	11	of	of	IN
cord-309871-y17puao2	67	12	ABCB1	abcb1	NN
cord-309871-y17puao2	67	13	,	,	,
cord-309871-y17puao2	67	14	meaning	mean	VBG
cord-309871-y17puao2	67	15	that	that	IN
cord-309871-y17puao2	67	16	the	the	DT
cord-309871-y17puao2	67	17	azithromycin	azithromycin	NNP
cord-309871-y17puao2	67	18	molecules	molecule	NNS
cord-309871-y17puao2	67	19	,	,	,
cord-309871-y17puao2	67	20	in	in	IN
cord-309871-y17puao2	67	21	addition	addition	NN
cord-309871-y17puao2	67	22	to	to	IN
cord-309871-y17puao2	67	23	their	-PRON-	PRP$
cord-309871-y17puao2	67	24	passive	passive	JJ
cord-309871-y17puao2	67	25	diffusional	diffusional	JJ
cord-309871-y17puao2	67	26	uptake	uptake	NN
cord-309871-y17puao2	67	27	,	,	,
cord-309871-y17puao2	67	28	are	be	VBP
cord-309871-y17puao2	67	29	actively	actively	RB
cord-309871-y17puao2	67	30	captured	capture	VBN
cord-309871-y17puao2	67	31	and	and	CC
cord-309871-y17puao2	67	32	trapped	trap	VBN
cord-309871-y17puao2	67	33	inside	inside	IN
cord-309871-y17puao2	67	34	the	the	DT
cord-309871-y17puao2	67	35	vesicles	vesicle	NNS
cord-309871-y17puao2	67	36	,	,	,
cord-309871-y17puao2	67	37	even	even	RB
cord-309871-y17puao2	67	38	if	if	IN
cord-309871-y17puao2	67	39	the	the	DT
cord-309871-y17puao2	67	40	vesicular	vesicular	JJ
cord-309871-y17puao2	67	41	intraluminal	intraluminal	JJ
cord-309871-y17puao2	67	42	pH	pH	NNP
cord-309871-y17puao2	67	43	increases	increase	NNS
cord-309871-y17puao2	67	44	and	and	CC
cord-309871-y17puao2	67	45	the	the	DT
cord-309871-y17puao2	67	46	percentage	percentage	NN
cord-309871-y17puao2	67	47	of	of	IN
cord-309871-y17puao2	67	48	protonic	protonic	JJ
cord-309871-y17puao2	67	49	drug	drug	NN
cord-309871-y17puao2	67	50	molecules	molecule	NNS
cord-309871-y17puao2	67	51	decreases	decrease	VBZ
cord-309871-y17puao2	67	52	enabling	enable	VBG
cord-309871-y17puao2	67	53	the	the	DT
cord-309871-y17puao2	67	54	backward	backward	JJ
cord-309871-y17puao2	67	55	diffusion	diffusion	NN
cord-309871-y17puao2	67	56	of	of	IN
cord-309871-y17puao2	67	57	neutral	neutral	JJ
cord-309871-y17puao2	67	58	species	specie	NNS
cord-309871-y17puao2	67	59	to	to	IN
cord-309871-y17puao2	67	60	the	the	DT
cord-309871-y17puao2	67	61	cytosol	cytosol	NN
cord-309871-y17puao2	67	62	(	(	-LRB-
cord-309871-y17puao2	67	63	Fig	Fig	NNP
cord-309871-y17puao2	67	64	.	.	.
cord-309871-y17puao2	67	65	1	1	CD
cord-309871-y17puao2	67	66	)	)	-RRB-
cord-309871-y17puao2	67	67	.	.	.
cord-309871-y17puao2	68	1	Therefore	therefore	RB
cord-309871-y17puao2	68	2	,	,	,
cord-309871-y17puao2	68	3	this	this	DT
cord-309871-y17puao2	68	4	could	could	MD
cord-309871-y17puao2	68	5	represent	represent	VB
cord-309871-y17puao2	68	6	an	an	DT
cord-309871-y17puao2	68	7	explanation	explanation	NN
cord-309871-y17puao2	68	8	for	for	IN
cord-309871-y17puao2	68	9	the	the	DT
cord-309871-y17puao2	68	10	synergistic	synergistic	JJ
cord-309871-y17puao2	68	11	effect	effect	NN
cord-309871-y17puao2	68	12	when	when	WRB
cord-309871-y17puao2	68	13	azithromycin	azithromycin	NNP
cord-309871-y17puao2	68	14	is	be	VBZ
cord-309871-y17puao2	68	15	added	add	VBN
cord-309871-y17puao2	68	16	to	to	TO
cord-309871-y17puao2	68	17	hydroxychloroquine	hydroxychloroquine	VB
cord-309871-y17puao2	68	18	or	or	CC
cord-309871-y17puao2	68	19	chloroquine	chloroquine	NN
cord-309871-y17puao2	68	20	.	.	.
cord-309871-y17puao2	69	1	At	at	RB
cord-309871-y17puao2	69	2	all	all	PDT
cord-309871-y17puao2	69	3	these	these	DT
cord-309871-y17puao2	69	4	intracellular	intracellular	JJ
cord-309871-y17puao2	69	5	stages	stage	NNS
cord-309871-y17puao2	69	6	,	,	,
cord-309871-y17puao2	69	7	ABCB1	ABCB1	NNP
cord-309871-y17puao2	69	8	can	can	MD
cord-309871-y17puao2	69	9	be	be	VB
cord-309871-y17puao2	69	10	a	a	DT
cord-309871-y17puao2	69	11	possible	possible	JJ
cord-309871-y17puao2	69	12	enhancer	enhancer	NN
cord-309871-y17puao2	69	13	by	by	IN
cord-309871-y17puao2	69	14	confining	confine	VBG
cord-309871-y17puao2	69	15	the	the	DT
cord-309871-y17puao2	69	16	substrate	substrate	NN
cord-309871-y17puao2	69	17	azithromycin	azithromycin	NNP
cord-309871-y17puao2	69	18	more	more	RBR
cord-309871-y17puao2	69	19	extensively	extensively	RB
cord-309871-y17puao2	69	20	as	as	IN
cord-309871-y17puao2	69	21	expected	expect	VBN
cord-309871-y17puao2	69	22	when	when	WRB
cord-309871-y17puao2	69	23	the	the	DT
cord-309871-y17puao2	69	24	trapping	trapping	NN
cord-309871-y17puao2	69	25	mechanism	mechanism	NN
cord-309871-y17puao2	69	26	is	be	VBZ
cord-309871-y17puao2	69	27	solely	solely	RB
cord-309871-y17puao2	69	28	limited	limited	JJ
cord-309871-y17puao2	69	29	to	to	IN
cord-309871-y17puao2	69	30	the	the	DT
cord-309871-y17puao2	69	31	protonated	protonate	VBN
cord-309871-y17puao2	69	32	-	-	HYPH
cord-309871-y17puao2	69	33	diffusion	diffusion	NN
cord-309871-y17puao2	69	34	explanation	explanation	NN
cord-309871-y17puao2	69	35	.	.	.
cord-309871-y17puao2	70	1	This	this	DT
cord-309871-y17puao2	70	2	first	first	JJ
cord-309871-y17puao2	70	3	hypothesis	hypothesis	NN
cord-309871-y17puao2	70	4	could	could	MD
cord-309871-y17puao2	70	5	be	be	VB
cord-309871-y17puao2	70	6	supported	support	VBN
cord-309871-y17puao2	70	7	by	by	IN
cord-309871-y17puao2	70	8	results	result	NNS
cord-309871-y17puao2	70	9	obtained	obtain	VBN
cord-309871-y17puao2	70	10	from	from	IN
cord-309871-y17puao2	70	11	a	a	DT
cord-309871-y17puao2	70	12	clinical	clinical	JJ
cord-309871-y17puao2	70	13	study	study	NN
cord-309871-y17puao2	70	14	where	where	WRB
cord-309871-y17puao2	70	15	increasing	increase	VBG
cord-309871-y17puao2	70	16	amounts	amount	NNS
cord-309871-y17puao2	70	17	of	of	IN
cord-309871-y17puao2	70	18	azithromycin	azithromycin	NN
cord-309871-y17puao2	70	19	(	(	-LRB-
cord-309871-y17puao2	70	20	from	from	IN
cord-309871-y17puao2	70	21	500	500	CD
cord-309871-y17puao2	70	22	mg	mg	NN
cord-309871-y17puao2	70	23	to	to	IN
cord-309871-y17puao2	70	24	2	2	CD
cord-309871-y17puao2	70	25	g	g	NN
cord-309871-y17puao2	70	26	)	)	-RRB-
cord-309871-y17puao2	70	27	combined	combine	VBN
cord-309871-y17puao2	70	28	with	with	IN
cord-309871-y17puao2	70	29	a	a	DT
cord-309871-y17puao2	70	30	fixed	fixed	JJ
cord-309871-y17puao2	70	31	dose	dose	NN
cord-309871-y17puao2	70	32	of	of	IN
cord-309871-y17puao2	70	33	600	600	CD
cord-309871-y17puao2	70	34	mg	mg	NNP
cord-309871-y17puao2	70	35	chloroquine	chloroquine	NNP
cord-309871-y17puao2	70	36	showed	show	VBD
cord-309871-y17puao2	70	37	a	a	DT
cord-309871-y17puao2	70	38	clear	clear	JJ
cord-309871-y17puao2	70	39	dose	dose	JJ
cord-309871-y17puao2	70	40	-	-	HYPH
cord-309871-y17puao2	70	41	response	response	NN
cord-309871-y17puao2	70	42	relationship	relationship	NN
cord-309871-y17puao2	70	43	with	with	IN
cord-309871-y17puao2	70	44	the	the	DT
cord-309871-y17puao2	70	45	maximum	maximum	JJ
cord-309871-y17puao2	70	46	clearance	clearance	NN
cord-309871-y17puao2	70	47	rates	rate	NNS
cord-309871-y17puao2	70	48	of	of	IN
cord-309871-y17puao2	70	49	P.	P.	NNP
cord-309871-y17puao2	70	50	falciparum	falciparum	NNS
cord-309871-y17puao2	70	51	observed	observe	VBN
cord-309871-y17puao2	70	52	with	with	IN
cord-309871-y17puao2	70	53	the	the	DT
cord-309871-y17puao2	70	54	highest	high	JJS
cord-309871-y17puao2	70	55	dose	dose	NN
cord-309871-y17puao2	70	56	of	of	IN
cord-309871-y17puao2	70	57	azithromycin	azithromycin	NN
cord-309871-y17puao2	70	58	(	(	-LRB-
cord-309871-y17puao2	70	59	11	11	CD
cord-309871-y17puao2	70	60	)	)	-RRB-
cord-309871-y17puao2	70	61	.	.	.
cord-309871-y17puao2	71	1	Moreover	moreover	RB
cord-309871-y17puao2	71	2	,	,	,
cord-309871-y17puao2	71	3	in	in	IN
cord-309871-y17puao2	71	4	vitro	vitro	FW
cord-309871-y17puao2	71	5	experiments	experiment	NNS
cord-309871-y17puao2	71	6	using	use	VBG
cord-309871-y17puao2	71	7	Vero	Vero	NNP
cord-309871-y17puao2	71	8	E6	E6	NNP
cord-309871-y17puao2	71	9	cells	cell	NNS
cord-309871-y17puao2	71	10	infected	infect	VBN
cord-309871-y17puao2	71	11	with	with	IN
cord-309871-y17puao2	71	12	SARS	SARS	NNP
cord-309871-y17puao2	71	13	-	-	HYPH
cord-309871-y17puao2	71	14	CoV-2	CoV-2	NNP
cord-309871-y17puao2	71	15	virus	virus	NN
cord-309871-y17puao2	71	16	have	have	VBP
cord-309871-y17puao2	71	17	also	also	RB
cord-309871-y17puao2	71	18	reported	report	VBN
cord-309871-y17puao2	71	19	concentration	concentration	NN
cord-309871-y17puao2	71	20	and	and	CC
cord-309871-y17puao2	71	21	time	time	NN
cord-309871-y17puao2	71	22	-	-	HYPH
cord-309871-y17puao2	71	23	dependent	dependent	JJ
cord-309871-y17puao2	71	24	effects	effect	NNS
cord-309871-y17puao2	71	25	of	of	IN
cord-309871-y17puao2	71	26	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	71	27	on	on	IN
cord-309871-y17puao2	71	28	the	the	DT
cord-309871-y17puao2	71	29	virus	virus	NN
cord-309871-y17puao2	71	30	cytotoxic	cytotoxic	JJ
cord-309871-y17puao2	71	31	EC50	EC50	NNP
cord-309871-y17puao2	71	32	values	value	NNS
cord-309871-y17puao2	71	33	,	,	,
cord-309871-y17puao2	71	34	which	which	WDT
cord-309871-y17puao2	71	35	decreased	decrease	VBD
cord-309871-y17puao2	71	36	with	with	IN
cord-309871-y17puao2	71	37	longer	long	JJR
cord-309871-y17puao2	71	38	incubation	incubation	NN
cord-309871-y17puao2	71	39	times	time	NNS
cord-309871-y17puao2	71	40	(	(	-LRB-
cord-309871-y17puao2	71	41	20	20	CD
cord-309871-y17puao2	71	42	,	,	,
cord-309871-y17puao2	71	43	21	21	CD
cord-309871-y17puao2	71	44	)	)	-RRB-
cord-309871-y17puao2	71	45	.	.	.
cord-309871-y17puao2	72	1	This	this	DT
cord-309871-y17puao2	72	2	suggests	suggest	VBZ
cord-309871-y17puao2	72	3	that	that	DT
cord-309871-y17puao2	72	4	time	time	NN
cord-309871-y17puao2	72	5	is	be	VBZ
cord-309871-y17puao2	72	6	required	require	VBN
cord-309871-y17puao2	72	7	for	for	IN
cord-309871-y17puao2	72	8	drug	drug	NN
cord-309871-y17puao2	72	9	accumulation	accumulation	NN
cord-309871-y17puao2	72	10	or/	or/	NNP
cord-309871-y17puao2	72	11	and	and	CC
cord-309871-y17puao2	72	12	drug	drug	NN
cord-309871-y17puao2	72	13	cytotoxicity	cytotoxicity	NN
cord-309871-y17puao2	72	14	kinetics	kinetic	NNS
cord-309871-y17puao2	72	15	.	.	.
cord-309871-y17puao2	73	1	These	these	DT
cord-309871-y17puao2	73	2	observations	observation	NNS
cord-309871-y17puao2	73	3	could	could	MD
cord-309871-y17puao2	73	4	be	be	VB
cord-309871-y17puao2	73	5	supported	support	VBN
cord-309871-y17puao2	73	6	by	by	IN
cord-309871-y17puao2	73	7	the	the	DT
cord-309871-y17puao2	73	8	long	long	RB
cord-309871-y17puao2	73	9	-	-	HYPH
cord-309871-y17puao2	73	10	lasting	last	VBG
cord-309871-y17puao2	73	11	ABCB1-mediated	ABCB1-mediated	NNP
cord-309871-y17puao2	73	12	exposure	exposure	NN
cord-309871-y17puao2	73	13	effect	effect	NN
cord-309871-y17puao2	73	14	of	of	IN
cord-309871-y17puao2	73	15	azithromycin	azithromycin	NNP
cord-309871-y17puao2	73	16	.	.	.
cord-309871-y17puao2	74	1	This	this	DT
cord-309871-y17puao2	74	2	azithromycin	azithromycin	NN
cord-309871-y17puao2	74	3	trapping	trap	VBG
cord-309871-y17puao2	74	4	effect	effect	NN
cord-309871-y17puao2	74	5	induced	induce	VBN
cord-309871-y17puao2	74	6	by	by	IN
cord-309871-y17puao2	74	7	ABCB1	ABCB1	NNP
cord-309871-y17puao2	74	8	could	could	MD
cord-309871-y17puao2	74	9	also	also	RB
cord-309871-y17puao2	74	10	be	be	VB
cord-309871-y17puao2	74	11	extended	extend	VBN
cord-309871-y17puao2	74	12	to	to	IN
cord-309871-y17puao2	74	13	the	the	DT
cord-309871-y17puao2	74	14	aminoquinoline	aminoquinoline	JJ
cord-309871-y17puao2	74	15	compounds	compound	NNS
cord-309871-y17puao2	74	16	to	to	IN
cord-309871-y17puao2	74	17	the	the	DT
cord-309871-y17puao2	74	18	extent	extent	NN
cord-309871-y17puao2	74	19	that	that	IN
cord-309871-y17puao2	74	20	they	-PRON-	PRP
cord-309871-y17puao2	74	21	could	could	MD
cord-309871-y17puao2	74	22	interact	interact	VB
cord-309871-y17puao2	74	23	with	with	IN
cord-309871-y17puao2	74	24	ABCB1	ABCB1	NNP
cord-309871-y17puao2	74	25	.	.	.
cord-309871-y17puao2	75	1	This	this	DT
cord-309871-y17puao2	75	2	could	could	MD
cord-309871-y17puao2	75	3	most	most	RBS
cord-309871-y17puao2	75	4	likely	likely	RB
cord-309871-y17puao2	75	5	occur	occur	VB
cord-309871-y17puao2	75	6	with	with	IN
cord-309871-y17puao2	75	7	chloroquine	chloroquine	NN
cord-309871-y17puao2	75	8	which	which	WDT
cord-309871-y17puao2	75	9	was	be	VBD
cord-309871-y17puao2	75	10	classified	classify	VBN
cord-309871-y17puao2	75	11	in	in	IN
cord-309871-y17puao2	75	12	several	several	JJ
cord-309871-y17puao2	75	13	vesicular	vesicular	JJ
cord-309871-y17puao2	75	14	and	and	CC
cord-309871-y17puao2	75	15	cellular	cellular	JJ
cord-309871-y17puao2	75	16	in	in	IN
cord-309871-y17puao2	75	17	vitro	vitro	FW
cord-309871-y17puao2	75	18	models	model	NNS
cord-309871-y17puao2	75	19	as	as	IN
cord-309871-y17puao2	75	20	a	a	DT
cord-309871-y17puao2	75	21	moderate	moderate	JJ
cord-309871-y17puao2	75	22	inhibitor	inhibitor	NN
cord-309871-y17puao2	75	23	and	and	CC
cord-309871-y17puao2	75	24	a	a	DT
cord-309871-y17puao2	75	25	nons	non	NNS
cord-309871-y17puao2	75	26	u	u	NN
cord-309871-y17puao2	75	27	b	b	NN
cord-309871-y17puao2	75	28	s	s	NN
cord-309871-y17puao2	76	1	t	t	NNP
cord-309871-y17puao2	76	2	r	r	NNP
cord-309871-y17puao2	76	3	a	a	DT
cord-309871-y17puao2	76	4	t	t	NN
cord-309871-y17puao2	77	1	e	e	LS
cord-309871-y17puao2	77	2	o	o	NN
cord-309871-y17puao2	78	1	f	f	NNP
cord-309871-y17puao2	79	1	A	a	DT
cord-309871-y17puao2	79	2	B	b	NN
cord-309871-y17puao2	79	3	C	c	NN
cord-309871-y17puao2	79	4	B	b	NN
cord-309871-y17puao2	79	5	1	1	CD
cord-309871-y17puao2	79	6	(	(	-LRB-
cord-309871-y17puao2	79	7	4	4	CD
cord-309871-y17puao2	79	8	0	0	CD
cord-309871-y17puao2	79	9	-4	-4	CD
cord-309871-y17puao2	79	10	3	3	CD
cord-309871-y17puao2	79	11	)	)	-RRB-
cord-309871-y17puao2	79	12	.	.	.
cord-309871-y17puao2	80	1	U	U	NNP
cord-309871-y17puao2	80	2	n	n	CC
cord-309871-y17puao2	80	3	f	f	NN
cord-309871-y17puao2	80	4	o	o	NN
cord-309871-y17puao2	80	5	r	r	NN
cord-309871-y17puao2	80	6	t	t	NN
cord-309871-y17puao2	80	7	u	u	NNP
cord-309871-y17puao2	80	8	n	n	NNP
cord-309871-y17puao2	80	9	a	a	DT
cord-309871-y17puao2	80	10	t	t	NN
cord-309871-y17puao2	80	11	e	e	NN
cord-309871-y17puao2	80	12	l	l	NNP
cord-309871-y17puao2	80	13	y	y	NNP
cord-309871-y17puao2	80	14	,	,	,
cord-309871-y17puao2	80	15	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	80	16	has	have	VBZ
cord-309871-y17puao2	80	17	been	be	VBN
cord-309871-y17puao2	80	18	demonstrated	demonstrate	VBN
cord-309871-y17puao2	80	19	neither	neither	CC
cord-309871-y17puao2	80	20	as	as	IN
cord-309871-y17puao2	80	21	a	a	DT
cord-309871-y17puao2	80	22	substrate	substrate	NN
cord-309871-y17puao2	80	23	nor	nor	CC
cord-309871-y17puao2	80	24	as	as	IN
cord-309871-y17puao2	80	25	inhibitor	inhibitor	NN
cord-309871-y17puao2	80	26	of	of	IN
cord-309871-y17puao2	80	27	ABCB1	ABCB1	NNP
cord-309871-y17puao2	80	28	with	with	IN
cord-309871-y17puao2	80	29	the	the	DT
cord-309871-y17puao2	80	30	usual	usual	JJ
cord-309871-y17puao2	80	31	in	in	IN
cord-309871-y17puao2	80	32	vitro	vitro	FW
cord-309871-y17puao2	80	33	models	model	NNS
cord-309871-y17puao2	80	34	.	.	.
cord-309871-y17puao2	81	1	Nevertheless	nevertheless	RB
cord-309871-y17puao2	81	2	,	,	,
cord-309871-y17puao2	81	3	this	this	DT
cord-309871-y17puao2	81	4	aminoquinoline	aminoquinoline	NN
cord-309871-y17puao2	81	5	has	have	VBZ
cord-309871-y17puao2	81	6	been	be	VBN
cord-309871-y17puao2	81	7	reported	report	VBN
cord-309871-y17puao2	81	8	in	in	IN
cord-309871-y17puao2	81	9	human	human	JJ
cord-309871-y17puao2	81	10	pharmacokinetics	pharmacokinetic	NNS
cord-309871-y17puao2	81	11	to	to	TO
cord-309871-y17puao2	81	12	interact	interact	VB
cord-309871-y17puao2	81	13	with	with	IN
cord-309871-y17puao2	81	14	digoxin	digoxin	NN
cord-309871-y17puao2	81	15	and	and	CC
cord-309871-y17puao2	81	16	nelfinavir	nelfinavir	NNS
cord-309871-y17puao2	81	17	,	,	,
cord-309871-y17puao2	81	18	two	two	CD
cord-309871-y17puao2	81	19	known	know	VBN
cord-309871-y17puao2	81	20	ABCB1	abcb1	NN
cord-309871-y17puao2	81	21	substrates	substrate	NNS
cord-309871-y17puao2	81	22	,	,	,
cord-309871-y17puao2	81	23	by	by	IN
cord-309871-y17puao2	81	24	moderately	moderately	RB
cord-309871-y17puao2	81	25	increasing	increase	VBG
cord-309871-y17puao2	81	26	their	-PRON-	PRP$
cord-309871-y17puao2	81	27	oral	oral	JJ
cord-309871-y17puao2	81	28	bioavailability	bioavailability	NN
cord-309871-y17puao2	81	29	(	(	-LRB-
cord-309871-y17puao2	81	30	44	44	CD
cord-309871-y17puao2	81	31	,	,	,
cord-309871-y17puao2	81	32	45	45	CD
cord-309871-y17puao2	81	33	)	)	-RRB-
cord-309871-y17puao2	81	34	.	.	.
cord-309871-y17puao2	82	1	Thus	thus	RB
cord-309871-y17puao2	82	2	,	,	,
cord-309871-y17puao2	82	3	all	all	PDT
cord-309871-y17puao2	82	4	these	these	DT
cord-309871-y17puao2	82	5	data	datum	NNS
cord-309871-y17puao2	82	6	suggest	suggest	VBP
cord-309871-y17puao2	82	7	that	that	IN
cord-309871-y17puao2	82	8	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	82	9	and	and	CC
cord-309871-y17puao2	82	10	chloroquine	chloroquine	NNP
cord-309871-y17puao2	82	11	could	could	MD
cord-309871-y17puao2	82	12	have	have	VB
cord-309871-y17puao2	82	13	a	a	DT
cord-309871-y17puao2	82	14	moderate	moderate	JJ
cord-309871-y17puao2	82	15	inhibition	inhibition	NN
cord-309871-y17puao2	82	16	effect	effect	NN
cord-309871-y17puao2	82	17	on	on	IN
cord-309871-y17puao2	82	18	the	the	DT
cord-309871-y17puao2	82	19	azithromycin	azithromycin	NNP
cord-309871-y17puao2	82	20	ABCB1-mediated	ABCB1-mediated	NNP
cord-309871-y17puao2	82	21	intravesicular	intravesicular	JJ
cord-309871-y17puao2	82	22	influx	influx	NN
cord-309871-y17puao2	82	23	.	.	.
cord-309871-y17puao2	83	1	They	-PRON-	PRP
cord-309871-y17puao2	83	2	also	also	RB
cord-309871-y17puao2	83	3	point	point	VBP
cord-309871-y17puao2	83	4	to	to	IN
cord-309871-y17puao2	83	5	the	the	DT
cord-309871-y17puao2	83	6	need	need	NN
cord-309871-y17puao2	83	7	to	to	TO
cord-309871-y17puao2	83	8	further	further	RB
cord-309871-y17puao2	83	9	investigate	investigate	VB
cord-309871-y17puao2	83	10	the	the	DT
cord-309871-y17puao2	83	11	inhibitor	inhibitor	NN
cord-309871-y17puao2	83	12	/	/	SYM
cord-309871-y17puao2	83	13	substrate	substrate	NN
cord-309871-y17puao2	83	14	status	status	NN
cord-309871-y17puao2	83	15	of	of	IN
cord-309871-y17puao2	83	16	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	83	17	towards	towards	IN
cord-309871-y17puao2	83	18	ABCB1	ABCB1	NNP
cord-309871-y17puao2	83	19	.	.	.
cord-309871-y17puao2	84	1	Additionally	additionally	RB
cord-309871-y17puao2	84	2	,	,	,
cord-309871-y17puao2	84	3	it	-PRON-	PRP
cord-309871-y17puao2	84	4	is	be	VBZ
cord-309871-y17puao2	84	5	noteworthy	noteworthy	JJ
cord-309871-y17puao2	84	6	that	that	IN
cord-309871-y17puao2	84	7	the	the	DT
cord-309871-y17puao2	84	8	antibiotic	antibiotic	JJ
cord-309871-y17puao2	84	9	and	and	CC
cord-309871-y17puao2	84	10	fluoroquinolone	fluoroquinolone	NN
cord-309871-y17puao2	84	11	ciprofloxacin	ciprofloxacin	NN
cord-309871-y17puao2	84	12	which	which	WDT
cord-309871-y17puao2	84	13	is	be	VBZ
cord-309871-y17puao2	84	14	also	also	RB
cord-309871-y17puao2	84	15	both	both	CC
cord-309871-y17puao2	84	16	a	a	DT
cord-309871-y17puao2	84	17	lysosomotropic	lysosomotropic	JJ
cord-309871-y17puao2	84	18	compound	compound	NN
cord-309871-y17puao2	84	19	with	with	IN
cord-309871-y17puao2	84	20	pKa	pKa	NNP
cord-309871-y17puao2	84	21	8.7	8.7	CD
cord-309871-y17puao2	84	22	and	and	CC
cord-309871-y17puao2	84	23	substrate	substrate	NN
cord-309871-y17puao2	84	24	of	of	IN
cord-309871-y17puao2	84	25	ABCB1	ABCB1	NNP
cord-309871-y17puao2	84	26	behaves	behave	VBZ
cord-309871-y17puao2	84	27	like	like	IN
cord-309871-y17puao2	84	28	azithromycin	azithromycin	NN
cord-309871-y17puao2	84	29	to	to	TO
cord-309871-y17puao2	84	30	synergize	synergize	VB
cord-309871-y17puao2	84	31	the	the	DT
cord-309871-y17puao2	84	32	anti	anti	JJ
cord-309871-y17puao2	84	33	-	-	JJ
cord-309871-y17puao2	84	34	infectious	infectious	JJ
cord-309871-y17puao2	84	35	effect	effect	NN
cord-309871-y17puao2	84	36	of	of	IN
cord-309871-y17puao2	84	37	chloroquine	chloroquine	NN
cord-309871-y17puao2	84	38	(	(	-LRB-
cord-309871-y17puao2	84	39	27	27	CD
cord-309871-y17puao2	84	40	)	)	-RRB-
cord-309871-y17puao2	84	41	.	.	.
cord-309871-y17puao2	85	1	This	this	DT
cord-309871-y17puao2	85	2	last	last	JJ
cord-309871-y17puao2	85	3	observation	observation	NN
cord-309871-y17puao2	85	4	appears	appear	VBZ
cord-309871-y17puao2	85	5	to	to	TO
cord-309871-y17puao2	85	6	demonstrate	demonstrate	VB
cord-309871-y17puao2	85	7	that	that	IN
cord-309871-y17puao2	85	8	the	the	DT
cord-309871-y17puao2	85	9	lysosomotropic	lysosomotropic	JJ
cord-309871-y17puao2	85	10	drug	drug	NN
cord-309871-y17puao2	85	11	property	property	NN
cord-309871-y17puao2	85	12	is	be	VBZ
cord-309871-y17puao2	85	13	certainly	certainly	RB
cord-309871-y17puao2	85	14	a	a	DT
cord-309871-y17puao2	85	15	key	key	JJ
cord-309871-y17puao2	85	16	factor	factor	NN
cord-309871-y17puao2	85	17	in	in	IN
cord-309871-y17puao2	85	18	the	the	DT
cord-309871-y17puao2	85	19	synergistic	synergistic	JJ
cord-309871-y17puao2	85	20	effect	effect	NN
cord-309871-y17puao2	85	21	of	of	IN
cord-309871-y17puao2	85	22	this	this	DT
cord-309871-y17puao2	85	23	drug	drug	NN
cord-309871-y17puao2	85	24	combination	combination	NN
cord-309871-y17puao2	85	25	.	.	.
cord-309871-y17puao2	86	1	The	the	DT
cord-309871-y17puao2	86	2	second	second	JJ
cord-309871-y17puao2	86	3	scenario	scenario	NN
cord-309871-y17puao2	86	4	could	could	MD
cord-309871-y17puao2	86	5	be	be	VB
cord-309871-y17puao2	86	6	similar	similar	JJ
cord-309871-y17puao2	86	7	to	to	IN
cord-309871-y17puao2	86	8	the	the	DT
cord-309871-y17puao2	86	9	well	well	RB
cord-309871-y17puao2	86	10	known	know	VBN
cord-309871-y17puao2	86	11	reversal	reversal	NN
cord-309871-y17puao2	86	12	of	of	IN
cord-309871-y17puao2	86	13	multidrug	multidrug	NN
cord-309871-y17puao2	86	14	resistance	resistance	NN
cord-309871-y17puao2	86	15	,	,	,
cord-309871-y17puao2	86	16	the	the	DT
cord-309871-y17puao2	86	17	MDR	MDR	NNP
cord-309871-y17puao2	86	18	effect	effect	NN
cord-309871-y17puao2	86	19	,	,	,
cord-309871-y17puao2	86	20	observed	observe	VBN
cord-309871-y17puao2	86	21	with	with	IN
cord-309871-y17puao2	86	22	anticancer	anticancer	JJ
cord-309871-y17puao2	86	23	drugs	drug	NNS
cord-309871-y17puao2	86	24	such	such	JJ
cord-309871-y17puao2	86	25	as	as	IN
cord-309871-y17puao2	86	26	doxorubicin	doxorubicin	NN
cord-309871-y17puao2	86	27	or	or	CC
cord-309871-y17puao2	86	28	daunomycin	daunomycin	NNS
cord-309871-y17puao2	86	29	which	which	WDT
cord-309871-y17puao2	86	30	are	be	VBP
cord-309871-y17puao2	86	31	also	also	RB
cord-309871-y17puao2	86	32	actively	actively	RB
cord-309871-y17puao2	86	33	trapped	trap	VBN
cord-309871-y17puao2	86	34	inside	inside	RB
cord-309871-y17puao2	86	35	lysosomes	lysosome	NNS
cord-309871-y17puao2	86	36	under	under	IN
cord-309871-y17puao2	86	37	ABCB1	abcb1	NN
cord-309871-y17puao2	86	38	active	active	JJ
cord-309871-y17puao2	86	39	influx	influx	NN
cord-309871-y17puao2	86	40	.	.	.
cord-309871-y17puao2	87	1	The	the	DT
cord-309871-y17puao2	87	2	administration	administration	NN
cord-309871-y17puao2	87	3	of	of	IN
cord-309871-y17puao2	87	4	ABCB1	ABCB1	NNP
cord-309871-y17puao2	87	5	inhibitors	inhibitor	NNS
cord-309871-y17puao2	87	6	,	,	,
cord-309871-y17puao2	87	7	like	like	IN
cord-309871-y17puao2	87	8	valspodar	valspodar	NNP
cord-309871-y17puao2	87	9	or	or	CC
cord-309871-y17puao2	87	10	elacridar	elacridar	NNP
cord-309871-y17puao2	87	11	,	,	,
cord-309871-y17puao2	87	12	tends	tend	VBZ
cord-309871-y17puao2	87	13	to	to	TO
cord-309871-y17puao2	87	14	displace	displace	VB
cord-309871-y17puao2	87	15	the	the	DT
cord-309871-y17puao2	87	16	anthracyclines	anthracycline	NNS
cord-309871-y17puao2	87	17	from	from	IN
cord-309871-y17puao2	87	18	the	the	DT
cord-309871-y17puao2	87	19	lysosomal	lysosomal	JJ
cord-309871-y17puao2	87	20	lumen	lumen	NN
cord-309871-y17puao2	87	21	into	into	IN
cord-309871-y17puao2	87	22	the	the	DT
cord-309871-y17puao2	87	23	cytosol	cytosol	NN
cord-309871-y17puao2	87	24	making	make	VBG
cord-309871-y17puao2	87	25	doxorubicin	doxorubicin	NN
cord-309871-y17puao2	87	26	available	available	JJ
cord-309871-y17puao2	87	27	for	for	IN
cord-309871-y17puao2	87	28	its	-PRON-	PRP$
cord-309871-y17puao2	87	29	nucleus	nucleus	NN
cord-309871-y17puao2	87	30	targets	target	NNS
cord-309871-y17puao2	87	31	(	(	-LRB-
cord-309871-y17puao2	87	32	46	46	CD
cord-309871-y17puao2	87	33	)	)	-RRB-
cord-309871-y17puao2	87	34	.	.	.
cord-309871-y17puao2	88	1	The	the	DT
cord-309871-y17puao2	88	2	translation	translation	NN
cord-309871-y17puao2	88	3	of	of	IN
cord-309871-y17puao2	88	4	this	this	DT
cord-309871-y17puao2	88	5	MDR	MDR	NNP
cord-309871-y17puao2	88	6	reversal	reversal	NN
cord-309871-y17puao2	88	7	to	to	IN
cord-309871-y17puao2	88	8	azithromycin	azithromycin	NNP
cord-309871-y17puao2	88	9	might	may	MD
cord-309871-y17puao2	88	10	suggest	suggest	VB
cord-309871-y17puao2	88	11	its	-PRON-	PRP$
cord-309871-y17puao2	88	12	ability	ability	NN
cord-309871-y17puao2	88	13	to	to	TO
cord-309871-y17puao2	88	14	inhibit	inhibit	VB
cord-309871-y17puao2	88	15	ABCB1	ABCB1	NNP
cord-309871-y17puao2	88	16	,	,	,
cord-309871-y17puao2	88	17	and	and	CC
cord-309871-y17puao2	88	18	therefore	therefore	RB
cord-309871-y17puao2	88	19	to	to	TO
cord-309871-y17puao2	88	20	increase	increase	VB
cord-309871-y17puao2	88	21	aminoquinoline	aminoquinoline	JJ
cord-309871-y17puao2	88	22	cytosolic	cytosolic	JJ
cord-309871-y17puao2	88	23	concentrations	concentration	NNS
cord-309871-y17puao2	88	24	which	which	WDT
cord-309871-y17puao2	88	25	could	could	MD
cord-309871-y17puao2	88	26	be	be	VB
cord-309871-y17puao2	88	27	active	active	JJ
cord-309871-y17puao2	88	28	for	for	IN
cord-309871-y17puao2	88	29	other	other	JJ
cord-309871-y17puao2	88	30	biological	biological	JJ
cord-309871-y17puao2	88	31	targets	target	NNS
cord-309871-y17puao2	88	32	and	and	CC
cord-309871-y17puao2	88	33	cellular	cellular	JJ
cord-309871-y17puao2	88	34	pathways	pathway	NNS
cord-309871-y17puao2	88	35	impacting	impact	VBG
cord-309871-y17puao2	88	36	the	the	DT
cord-309871-y17puao2	88	37	virus	virus	NN
cord-309871-y17puao2	88	38	development	development	NN
cord-309871-y17puao2	88	39	(	(	-LRB-
cord-309871-y17puao2	88	40	4	4	CD
cord-309871-y17puao2	88	41	,	,	,
cord-309871-y17puao2	88	42	9	9	CD
cord-309871-y17puao2	88	43	,	,	,
cord-309871-y17puao2	88	44	16	16	CD
cord-309871-y17puao2	88	45	)	)	-RRB-
cord-309871-y17puao2	88	46	.	.	.
cord-309871-y17puao2	89	1	Therefore	therefore	RB
cord-309871-y17puao2	89	2	,	,	,
cord-309871-y17puao2	89	3	this	this	DT
cord-309871-y17puao2	89	4	second	second	JJ
cord-309871-y17puao2	89	5	scenario	scenario	NN
cord-309871-y17puao2	89	6	seems	seem	VBZ
cord-309871-y17puao2	89	7	unlikely	unlikely	JJ
cord-309871-y17puao2	89	8	as	as	IN
cord-309871-y17puao2	89	9	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	89	10	and	and	CC
cord-309871-y17puao2	89	11	chloroquine	chloroquine	NN
cord-309871-y17puao2	89	12	are	be	VBP
cord-309871-y17puao2	89	13	not	not	RB
cord-309871-y17puao2	89	14	substrates	substrate	NNS
cord-309871-y17puao2	89	15	of	of	IN
cord-309871-y17puao2	89	16	ABCB1	ABCB1	NNP
cord-309871-y17puao2	89	17	.	.	.
cord-309871-y17puao2	90	1	The	the	DT
cord-309871-y17puao2	90	2	diagram	diagram	NN
cord-309871-y17puao2	90	3	shows	show	VBZ
cord-309871-y17puao2	90	4	how	how	WRB
cord-309871-y17puao2	90	5	the	the	DT
cord-309871-y17puao2	90	6	unionized	unionized	JJ
cord-309871-y17puao2	90	7	drugs	drug	NNS
cord-309871-y17puao2	90	8	can	can	MD
cord-309871-y17puao2	90	9	readily	readily	RB
cord-309871-y17puao2	90	10	diffuse	diffuse	VB
cord-309871-y17puao2	90	11	across	across	IN
cord-309871-y17puao2	90	12	lysosomal	lysosomal	JJ
cord-309871-y17puao2	90	13	membranes	membrane	NNS
cord-309871-y17puao2	90	14	.	.	.
cord-309871-y17puao2	91	1	Due	due	IN
cord-309871-y17puao2	91	2	to	to	IN
cord-309871-y17puao2	91	3	the	the	DT
cord-309871-y17puao2	91	4	acidic	acidic	JJ
cord-309871-y17puao2	91	5	environment	environment	NN
cord-309871-y17puao2	91	6	of	of	IN
cord-309871-y17puao2	91	7	the	the	DT
cord-309871-y17puao2	91	8	lysosome	lysosome	NN
cord-309871-y17puao2	91	9	,	,	,
cord-309871-y17puao2	91	10	the	the	DT
cord-309871-y17puao2	91	11	equilibrium	equilibrium	NN
cord-309871-y17puao2	91	12	between	between	IN
cord-309871-y17puao2	91	13	charged	charged	JJ
cord-309871-y17puao2	91	14	and	and	CC
cord-309871-y17puao2	91	15	uncharged	uncharged	JJ
cord-309871-y17puao2	91	16	drug	drug	NN
cord-309871-y17puao2	91	17	species	species	NN
cord-309871-y17puao2	91	18	shifts	shift	NNS
cord-309871-y17puao2	91	19	in	in	IN
cord-309871-y17puao2	91	20	favor	favor	NN
cord-309871-y17puao2	91	21	of	of	IN
cord-309871-y17puao2	91	22	the	the	DT
cord-309871-y17puao2	91	23	ionized	ionize	VBN
cord-309871-y17puao2	91	24	species	specie	NNS
cord-309871-y17puao2	91	25	,	,	,
cord-309871-y17puao2	91	26	thus	thus	RB
cord-309871-y17puao2	91	27	limiting	limit	VBG
cord-309871-y17puao2	91	28	their	-PRON-	PRP$
cord-309871-y17puao2	91	29	backward	backward	JJ
cord-309871-y17puao2	91	30	diffusion	diffusion	NN
cord-309871-y17puao2	91	31	into	into	IN
cord-309871-y17puao2	91	32	the	the	DT
cord-309871-y17puao2	91	33	cytosol	cytosol	NN
cord-309871-y17puao2	91	34	.	.	.
cord-309871-y17puao2	92	1	As	as	IN
cord-309871-y17puao2	92	2	a	a	DT
cord-309871-y17puao2	92	3	substrate	substrate	NN
cord-309871-y17puao2	92	4	of	of	IN
cord-309871-y17puao2	92	5	ABCB1	ABCB1	NNP
cord-309871-y17puao2	92	6	,	,	,
cord-309871-y17puao2	92	7	the	the	DT
cord-309871-y17puao2	92	8	active	active	JJ
cord-309871-y17puao2	92	9	uptake	uptake	NN
cord-309871-y17puao2	92	10	of	of	IN
cord-309871-y17puao2	92	11	azithromycin	azithromycin	NNP
cord-309871-y17puao2	92	12	contributes	contribute	VBZ
cord-309871-y17puao2	92	13	to	to	IN
cord-309871-y17puao2	92	14	the	the	DT
cord-309871-y17puao2	92	15	enhancement	enhancement	NN
cord-309871-y17puao2	92	16	of	of	IN
cord-309871-y17puao2	92	17	this	this	DT
cord-309871-y17puao2	92	18	trapping	trap	VBG
cord-309871-y17puao2	92	19	effect	effect	NN
cord-309871-y17puao2	92	20	and	and	CC
cord-309871-y17puao2	92	21	to	to	IN
cord-309871-y17puao2	92	22	the	the	DT
cord-309871-y17puao2	92	23	neutralization	neutralization	NN
cord-309871-y17puao2	92	24	of	of	IN
cord-309871-y17puao2	92	25	the	the	DT
cord-309871-y17puao2	92	26	acidic	acidic	JJ
cord-309871-y17puao2	92	27	pH.	ph.	NN
cord-309871-y17puao2	93	1	This	this	DT
cord-309871-y17puao2	93	2	last	last	JJ
cord-309871-y17puao2	93	3	effect	effect	NN
cord-309871-y17puao2	93	4	contributes	contribute	VBZ
cord-309871-y17puao2	93	5	to	to	IN
cord-309871-y17puao2	93	6	a	a	DT
cord-309871-y17puao2	93	7	cascade	cascade	NN
cord-309871-y17puao2	93	8	of	of	IN
cord-309871-y17puao2	93	9	antiinflammatory	antiinflammatory	JJ
cord-309871-y17puao2	93	10	and	and	CC
cord-309871-y17puao2	93	11	antiviral	antiviral	JJ
cord-309871-y17puao2	93	12	activities	activity	NNS
cord-309871-y17puao2	94	1	Nevertheless	nevertheless	RB
cord-309871-y17puao2	94	2	,	,	,
cord-309871-y17puao2	94	3	this	this	DT
cord-309871-y17puao2	94	4	drug	drug	NN
cord-309871-y17puao2	94	5	release	release	NN
cord-309871-y17puao2	94	6	from	from	IN
cord-309871-y17puao2	94	7	the	the	DT
cord-309871-y17puao2	94	8	vesicle	vesicle	NN
cord-309871-y17puao2	94	9	lumen	lumen	NN
cord-309871-y17puao2	94	10	to	to	IN
cord-309871-y17puao2	94	11	the	the	DT
cord-309871-y17puao2	94	12	cytosol	cytosol	NN
cord-309871-y17puao2	94	13	could	could	MD
cord-309871-y17puao2	94	14	proceed	proceed	VB
cord-309871-y17puao2	94	15	from	from	IN
cord-309871-y17puao2	94	16	the	the	DT
cord-309871-y17puao2	94	17	deleterious	deleterious	JJ
cord-309871-y17puao2	94	18	effects	effect	NNS
cord-309871-y17puao2	94	19	of	of	IN
cord-309871-y17puao2	94	20	these	these	DT
cord-309871-y17puao2	94	21	cationic	cationic	JJ
cord-309871-y17puao2	94	22	amphiphilic	amphiphilic	JJ
cord-309871-y17puao2	94	23	drugs	drug	NNS
cord-309871-y17puao2	94	24	on	on	IN
cord-309871-y17puao2	94	25	lysosomal	lysosomal	JJ
cord-309871-y17puao2	94	26	viability	viability	NN
cord-309871-y17puao2	94	27	.	.	.
cord-309871-y17puao2	95	1	As	as	IN
cord-309871-y17puao2	95	2	a	a	DT
cord-309871-y17puao2	95	3	result	result	NN
cord-309871-y17puao2	95	4	of	of	IN
cord-309871-y17puao2	95	5	their	-PRON-	PRP$
cord-309871-y17puao2	95	6	over	over	IN
cord-309871-y17puao2	95	7	-	-	HYPH
cord-309871-y17puao2	95	8	accumulation	accumulation	NN
cord-309871-y17puao2	95	9	in	in	IN
cord-309871-y17puao2	95	10	the	the	DT
cord-309871-y17puao2	95	11	endolysosomal	endolysosomal	JJ
cord-309871-y17puao2	95	12	lumen	lumen	NN
cord-309871-y17puao2	95	13	which	which	WDT
cord-309871-y17puao2	95	14	could	could	MD
cord-309871-y17puao2	95	15	be	be	VB
cord-309871-y17puao2	95	16	exacerbated	exacerbate	VBN
cord-309871-y17puao2	95	17	by	by	IN
cord-309871-y17puao2	95	18	the	the	DT
cord-309871-y17puao2	95	19	azithromycin	azithromycin	NNP
cord-309871-y17puao2	95	20	effect	effect	NN
cord-309871-y17puao2	95	21	on	on	IN
cord-309871-y17puao2	95	22	ABCB1	ABCB1	NNP
cord-309871-y17puao2	95	23	,	,	,
cord-309871-y17puao2	95	24	they	-PRON-	PRP
cord-309871-y17puao2	95	25	could	could	MD
cord-309871-y17puao2	95	26	permeabilize	permeabilize	VB
cord-309871-y17puao2	95	27	the	the	DT
cord-309871-y17puao2	95	28	lysosomal	lysosomal	JJ
cord-309871-y17puao2	95	29	membranes	membrane	NNS
cord-309871-y17puao2	95	30	to	to	IN
cord-309871-y17puao2	95	31	protons	proton	NNS
cord-309871-y17puao2	95	32	,	,	,
cord-309871-y17puao2	95	33	Cl	Cl	NNP
cord-309871-y17puao2	95	34	−	−	NNP
cord-309871-y17puao2	95	35	and	and	CC
cord-309871-y17puao2	95	36	water	water	NN
cord-309871-y17puao2	95	37	causing	cause	VBG
cord-309871-y17puao2	95	38	enlargement	enlargement	NN
cord-309871-y17puao2	95	39	of	of	IN
cord-309871-y17puao2	95	40	the	the	DT
cord-309871-y17puao2	95	41	lysosomes	lysosome	NNS
cord-309871-y17puao2	95	42	and	and	CC
cord-309871-y17puao2	95	43	phospholipidosis	phospholipidosis	NN
cord-309871-y17puao2	95	44	(	(	-LRB-
cord-309871-y17puao2	95	45	47	47	CD
cord-309871-y17puao2	95	46	)	)	-RRB-
cord-309871-y17puao2	95	47	.	.	.
cord-309871-y17puao2	96	1	Interestingly	interestingly	RB
cord-309871-y17puao2	96	2	,	,	,
cord-309871-y17puao2	96	3	azithromycin	azithromycin	NN
cord-309871-y17puao2	96	4	,	,	,
cord-309871-y17puao2	96	5	chloroquine	chloroquine	NN
cord-309871-y17puao2	96	6	,	,	,
cord-309871-y17puao2	96	7	and	and	CC
cord-309871-y17puao2	96	8	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	96	9	have	have	VBP
cord-309871-y17puao2	96	10	been	be	VBN
cord-309871-y17puao2	96	11	all	all	RB
cord-309871-y17puao2	96	12	reported	report	VBN
cord-309871-y17puao2	96	13	as	as	IN
cord-309871-y17puao2	96	14	responsible	responsible	JJ
cord-309871-y17puao2	96	15	of	of	IN
cord-309871-y17puao2	96	16	these	these	DT
cord-309871-y17puao2	96	17	types	type	NNS
cord-309871-y17puao2	96	18	of	of	IN
cord-309871-y17puao2	96	19	endolysosomal	endolysosomal	JJ
cord-309871-y17puao2	96	20	damages	damage	NNS
cord-309871-y17puao2	96	21	which	which	WDT
cord-309871-y17puao2	96	22	can	can	MD
cord-309871-y17puao2	96	23	affect	affect	VB
cord-309871-y17puao2	96	24	vesicular	vesicular	JJ
cord-309871-y17puao2	96	25	trafficking	trafficking	NN
cord-309871-y17puao2	96	26	by	by	IN
cord-309871-y17puao2	96	27	inhibiting	inhibit	VBG
cord-309871-y17puao2	96	28	the	the	DT
cord-309871-y17puao2	96	29	surface	surface	NN
cord-309871-y17puao2	96	30	expression	expression	NN
cord-309871-y17puao2	96	31	of	of	IN
cord-309871-y17puao2	96	32	receptors	receptor	NNS
cord-309871-y17puao2	96	33	,	,	,
cord-309871-y17puao2	96	34	the	the	DT
cord-309871-y17puao2	96	35	fusion	fusion	NN
cord-309871-y17puao2	96	36	to	to	IN
cord-309871-y17puao2	96	37	autophagosomes	autophagosomes	NNP
cord-309871-y17puao2	96	38	,	,	,
cord-309871-y17puao2	96	39	and	and	CC
cord-309871-y17puao2	96	40	lipid	lipid	NN
cord-309871-y17puao2	96	41	metabolism	metabolism	NN
cord-309871-y17puao2	96	42	which	which	WDT
cord-309871-y17puao2	96	43	indirectly	indirectly	RB
cord-309871-y17puao2	96	44	contributes	contribute	VBZ
cord-309871-y17puao2	96	45	to	to	IN
cord-309871-y17puao2	96	46	the	the	DT
cord-309871-y17puao2	96	47	inhibition	inhibition	NN
cord-309871-y17puao2	96	48	of	of	IN
cord-309871-y17puao2	96	49	the	the	DT
cord-309871-y17puao2	96	50	cytokine	cytokine	NN
cord-309871-y17puao2	96	51	production	production	NN
cord-309871-y17puao2	96	52	.	.	.
cord-309871-y17puao2	97	1	All	all	PDT
cord-309871-y17puao2	97	2	these	these	DT
cord-309871-y17puao2	97	3	impairments	impairment	NNS
cord-309871-y17puao2	97	4	could	could	MD
cord-309871-y17puao2	97	5	contribute	contribute	VB
cord-309871-y17puao2	97	6	to	to	IN
cord-309871-y17puao2	97	7	the	the	DT
cord-309871-y17puao2	97	8	panel	panel	NN
cord-309871-y17puao2	97	9	of	of	IN
cord-309871-y17puao2	97	10	cytotoxic	cytotoxic	JJ
cord-309871-y17puao2	97	11	mechanisms	mechanism	NNS
cord-309871-y17puao2	97	12	affecting	affect	VBG
cord-309871-y17puao2	97	13	the	the	DT
cord-309871-y17puao2	97	14	SARS	SARS	NNP
cord-309871-y17puao2	97	15	-	-	HYPH
cord-309871-y17puao2	97	16	CoV-2	CoV-2	NNP
cord-309871-y17puao2	97	17	replication	replication	NN
cord-309871-y17puao2	97	18	cycle	cycle	NN
cord-309871-y17puao2	97	19	as	as	RB
cord-309871-y17puao2	97	20	well	well	RB
cord-309871-y17puao2	97	21	as	as	IN
cord-309871-y17puao2	97	22	the	the	DT
cord-309871-y17puao2	97	23	risks	risk	NNS
cord-309871-y17puao2	97	24	of	of	IN
cord-309871-y17puao2	97	25	organtoxicity	organtoxicity	NN
cord-309871-y17puao2	97	26	like	like	IN
cord-309871-y17puao2	97	27	cardiomyopathy	cardiomyopathy	NN
cord-309871-y17puao2	97	28	following	follow	VBG
cord-309871-y17puao2	97	29	this	this	DT
cord-309871-y17puao2	97	30	drug	drug	NN
cord-309871-y17puao2	97	31	combination	combination	NN
cord-309871-y17puao2	97	32	(	(	-LRB-
cord-309871-y17puao2	97	33	29	29	CD
cord-309871-y17puao2	97	34	,	,	,
cord-309871-y17puao2	97	35	48	48	CD
cord-309871-y17puao2	97	36	,	,	,
cord-309871-y17puao2	97	37	49	49	CD
cord-309871-y17puao2	97	38	)	)	-RRB-
cord-309871-y17puao2	97	39	.	.	.
cord-309871-y17puao2	98	1	They	-PRON-	PRP
cord-309871-y17puao2	98	2	also	also	RB
cord-309871-y17puao2	98	3	highlight	highlight	VBP
cord-309871-y17puao2	98	4	a	a	DT
cord-309871-y17puao2	98	5	critical	critical	JJ
cord-309871-y17puao2	98	6	need	need	NN
cord-309871-y17puao2	98	7	for	for	IN
cord-309871-y17puao2	98	8	optimal	optimal	JJ
cord-309871-y17puao2	98	9	dosing	dosing	NN
cord-309871-y17puao2	98	10	of	of	IN
cord-309871-y17puao2	98	11	both	both	DT
cord-309871-y17puao2	98	12	drugs	drug	NNS
cord-309871-y17puao2	98	13	using	use	VBG
cord-309871-y17puao2	98	14	PBPK	PBPK	NNP
cord-309871-y17puao2	98	15	and	and	CC
cord-309871-y17puao2	98	16	PKPD	PKPD	NNP
cord-309871-y17puao2	98	17	modelings	modeling	NNS
cord-309871-y17puao2	98	18	to	to	TO
cord-309871-y17puao2	98	19	achieve	achieve	VB
cord-309871-y17puao2	98	20	both	both	DT
cord-309871-y17puao2	98	21	safety	safety	NN
cord-309871-y17puao2	98	22	and	and	CC
cord-309871-y17puao2	98	23	efficacy	efficacy	NN
cord-309871-y17puao2	98	24	(	(	-LRB-
cord-309871-y17puao2	98	25	21	21	CD
cord-309871-y17puao2	98	26	,	,	,
cord-309871-y17puao2	98	27	22	22	CD
cord-309871-y17puao2	98	28	)	)	-RRB-
cord-309871-y17puao2	98	29	.	.	.
cord-309871-y17puao2	99	1	To	to	TO
cord-309871-y17puao2	99	2	sum	sum	VB
cord-309871-y17puao2	99	3	up	up	RP
cord-309871-y17puao2	99	4	,	,	,
cord-309871-y17puao2	99	5	the	the	DT
cord-309871-y17puao2	99	6	intracellular	intracellular	JJ
cord-309871-y17puao2	99	7	ABCB1	ABCB1	NNP
cord-309871-y17puao2	99	8	could	could	MD
cord-309871-y17puao2	99	9	represent	represent	VB
cord-309871-y17puao2	99	10	a	a	DT
cord-309871-y17puao2	99	11	potent	potent	JJ
cord-309871-y17puao2	99	12	target	target	NN
cord-309871-y17puao2	99	13	for	for	IN
cord-309871-y17puao2	99	14	enhancing	enhance	VBG
cord-309871-y17puao2	99	15	the	the	DT
cord-309871-y17puao2	99	16	antiviral	antiviral	JJ
cord-309871-y17puao2	99	17	and	and	CC
cord-309871-y17puao2	99	18	antiinflammatory	antiinflammatory	JJ
cord-309871-y17puao2	99	19	activities	activity	NNS
cord-309871-y17puao2	99	20	of	of	IN
cord-309871-y17puao2	99	21	the	the	DT
cord-309871-y17puao2	99	22	aminoquinolines	aminoquinoline	NNS
cord-309871-y17puao2	99	23	when	when	WRB
cord-309871-y17puao2	99	24	lysosomotropic	lysosomotropic	NNP
cord-309871-y17puao2	99	25	ABCB1	ABCB1	NNP
cord-309871-y17puao2	99	26	substrates	substrate	NNS
cord-309871-y17puao2	99	27	like	like	IN
cord-309871-y17puao2	99	28	azithromycin	azithromycin	NN
cord-309871-y17puao2	99	29	or	or	CC
cord-309871-y17puao2	99	30	ciprofloxacin	ciprofloxacin	NN
cord-309871-y17puao2	99	31	are	be	VBP
cord-309871-y17puao2	99	32	combined	combine	VBN
cord-309871-y17puao2	99	33	.	.	.
cord-309871-y17puao2	100	1	This	this	DT
cord-309871-y17puao2	100	2	could	could	MD
cord-309871-y17puao2	100	3	explain	explain	VB
cord-309871-y17puao2	100	4	why	why	WRB
cord-309871-y17puao2	100	5	the	the	DT
cord-309871-y17puao2	100	6	association	association	NN
cord-309871-y17puao2	100	7	strategy	strategy	NN
cord-309871-y17puao2	100	8	leads	lead	VBZ
cord-309871-y17puao2	100	9	to	to	IN
cord-309871-y17puao2	100	10	apparent	apparent	JJ
cord-309871-y17puao2	100	11	rapid	rapid	JJ
cord-309871-y17puao2	100	12	virus	virus	NN
cord-309871-y17puao2	100	13	clearance	clearance	NN
cord-309871-y17puao2	100	14	and	and	CC
cord-309871-y17puao2	100	15	better	well	JJR
cord-309871-y17puao2	100	16	clinical	clinical	JJ
cord-309871-y17puao2	100	17	benefit	benefit	NN
cord-309871-y17puao2	100	18	vs.	vs.	FW
cord-309871-y17puao2	100	19	aminoquinoline	aminoquinoline	JJ
cord-309871-y17puao2	100	20	use	use	NN
cord-309871-y17puao2	100	21	alone	alone	JJ
cord-309871-y17puao2	100	22	(	(	-LRB-
cord-309871-y17puao2	100	23	1	1	CD
cord-309871-y17puao2	100	24	)	)	-RRB-
cord-309871-y17puao2	100	25	.	.	.
cord-309871-y17puao2	101	1	Moreover	moreover	RB
cord-309871-y17puao2	101	2	,	,	,
cord-309871-y17puao2	101	3	these	these	DT
cord-309871-y17puao2	101	4	observations	observation	NNS
cord-309871-y17puao2	101	5	justify	justify	VBP
cord-309871-y17puao2	101	6	the	the	DT
cord-309871-y17puao2	101	7	bi	bi	JJ
cord-309871-y17puao2	101	8	-	-	HYPH
cord-309871-y17puao2	101	9	therapy	therapy	NNP
cord-309871-y17puao2	101	10	administration	administration	NN
cord-309871-y17puao2	101	11	in	in	IN
cord-309871-y17puao2	101	12	the	the	DT
cord-309871-y17puao2	101	13	early	early	JJ
cord-309871-y17puao2	101	14	stage	stage	NN
cord-309871-y17puao2	101	15	of	of	IN
cord-309871-y17puao2	101	16	the	the	DT
cord-309871-y17puao2	101	17	disease	disease	NN
cord-309871-y17puao2	101	18	or	or	CC
cord-309871-y17puao2	101	19	for	for	IN
cord-309871-y17puao2	101	20	prophylactic	prophylactic	JJ
cord-309871-y17puao2	101	21	use	use	NN
cord-309871-y17puao2	101	22	,	,	,
cord-309871-y17puao2	101	23	i.e.	i.e.	FW
cord-309871-y17puao2	101	24	,	,	,
cord-309871-y17puao2	101	25	when	when	WRB
cord-309871-y17puao2	101	26	the	the	DT
cord-309871-y17puao2	101	27	virus	virus	NN
cord-309871-y17puao2	101	28	distributes	distribute	VBZ
cord-309871-y17puao2	101	29	within	within	IN
cord-309871-y17puao2	101	30	the	the	DT
cord-309871-y17puao2	101	31	disease	disease	NN
cord-309871-y17puao2	101	32	target	target	NN
cord-309871-y17puao2	101	33	cells	cell	NNS
cord-309871-y17puao2	101	34	,	,	,
cord-309871-y17puao2	101	35	such	such	JJ
cord-309871-y17puao2	101	36	as	as	IN
cord-309871-y17puao2	101	37	the	the	DT
cord-309871-y17puao2	101	38	pulmonary	pulmonary	JJ
cord-309871-y17puao2	101	39	epithelial	epithelial	JJ
cord-309871-y17puao2	101	40	cells	cell	NNS
cord-309871-y17puao2	101	41	.	.	.
cord-309871-y17puao2	102	1	Experimental	experimental	JJ
cord-309871-y17puao2	102	2	assessments	assessment	NNS
cord-309871-y17puao2	102	3	of	of	IN
cord-309871-y17puao2	102	4	this	this	DT
cord-309871-y17puao2	102	5	hypothetical	hypothetical	JJ
cord-309871-y17puao2	102	6	ABCB1	ABCB1	NNP
cord-309871-y17puao2	102	7	role	role	NN
cord-309871-y17puao2	102	8	could	could	MD
cord-309871-y17puao2	102	9	be	be	VB
cord-309871-y17puao2	102	10	easily	easily	RB
cord-309871-y17puao2	102	11	investigated	investigate	VBN
cord-309871-y17puao2	102	12	using	use	VBG
cord-309871-y17puao2	102	13	both	both	DT
cord-309871-y17puao2	102	14	in	in	IN
cord-309871-y17puao2	102	15	vitro	vitro	FW
cord-309871-y17puao2	102	16	cellular	cellular	JJ
cord-309871-y17puao2	102	17	models	model	NNS
cord-309871-y17puao2	102	18	currently	currently	RB
cord-309871-y17puao2	102	19	used	use	VBN
cord-309871-y17puao2	102	20	with	with	IN
cord-309871-y17puao2	102	21	SARS	SARS	NNP
cord-309871-y17puao2	102	22	-	-	HYPH
cord-309871-y17puao2	102	23	CoV-2	CoV-2	NNP
cord-309871-y17puao2	102	24	and	and	CC
cord-309871-y17puao2	102	25	widely	widely	RB
cord-309871-y17puao2	102	26	developed	develop	VBN
cord-309871-y17puao2	102	27	for	for	IN
cord-309871-y17puao2	102	28	ABCB1	abcb1	NN
cord-309871-y17puao2	102	29	transport	transport	NN
cord-309871-y17puao2	102	30	(	(	-LRB-
cord-309871-y17puao2	102	31	19	19	CD
cord-309871-y17puao2	102	32	,	,	,
cord-309871-y17puao2	102	33	20	20	CD
cord-309871-y17puao2	102	34	,	,	,
cord-309871-y17puao2	102	35	46	46	CD
cord-309871-y17puao2	102	36	,	,	,
cord-309871-y17puao2	102	37	50	50	CD
cord-309871-y17puao2	102	38	)	)	-RRB-
cord-309871-y17puao2	102	39	.	.	.
cord-309871-y17puao2	103	1	Moreover	moreover	RB
cord-309871-y17puao2	103	2	,	,	,
cord-309871-y17puao2	103	3	the	the	DT
cord-309871-y17puao2	103	4	reported	report	VBN
cord-309871-y17puao2	103	5	co	co	NN
cord-309871-y17puao2	103	6	-	-	NN
cord-309871-y17puao2	103	7	localization	localization	NN
cord-309871-y17puao2	103	8	of	of	IN
cord-309871-y17puao2	103	9	ABCB1	abcb1	NN
cord-309871-y17puao2	103	10	with	with	IN
cord-309871-y17puao2	103	11	other	other	JJ
cord-309871-y17puao2	103	12	ABCs	abc	NNS
cord-309871-y17puao2	103	13	on	on	IN
cord-309871-y17puao2	103	14	the	the	DT
cord-309871-y17puao2	103	15	lysosomal	lysosomal	JJ
cord-309871-y17puao2	103	16	membranes	membrane	NNS
cord-309871-y17puao2	103	17	,	,	,
cord-309871-y17puao2	103	18	such	such	JJ
cord-309871-y17puao2	103	19	as	as	IN
cord-309871-y17puao2	103	20	ABCG2	ABCG2	NNS
cord-309871-y17puao2	103	21	,	,	,
cord-309871-y17puao2	103	22	ABCC1	ABCC1	NNP
cord-309871-y17puao2	103	23	,	,	,
cord-309871-y17puao2	103	24	and	and	CC
cord-309871-y17puao2	103	25	ABCC2	abcc2	NN
cord-309871-y17puao2	103	26	could	could	MD
cord-309871-y17puao2	103	27	also	also	RB
cord-309871-y17puao2	103	28	expand	expand	VB
cord-309871-y17puao2	103	29	this	this	DT
cord-309871-y17puao2	103	30	experimental	experimental	JJ
cord-309871-y17puao2	103	31	field	field	NN
cord-309871-y17puao2	103	32	of	of	IN
cord-309871-y17puao2	103	33	investigation	investigation	NN
cord-309871-y17puao2	103	34	as	as	IN
cord-309871-y17puao2	103	35	to	to	IN
cord-309871-y17puao2	103	36	their	-PRON-	PRP$
cord-309871-y17puao2	103	37	possible	possible	JJ
cord-309871-y17puao2	103	38	involvement	involvement	NN
cord-309871-y17puao2	103	39	in	in	IN
cord-309871-y17puao2	103	40	the	the	DT
cord-309871-y17puao2	103	41	activity	activity	NN
cord-309871-y17puao2	103	42	of	of	IN
cord-309871-y17puao2	103	43	these	these	DT
cord-309871-y17puao2	103	44	lysosomotropic	lysosomotropic	JJ
cord-309871-y17puao2	103	45	drugs	drug	NNS
cord-309871-y17puao2	103	46	(	(	-LRB-
cord-309871-y17puao2	103	47	51	51	CD
cord-309871-y17puao2	103	48	)	)	-RRB-
cord-309871-y17puao2	103	49	.	.	.
cord-309871-y17puao2	104	1	By	by	IN
cord-309871-y17puao2	104	2	taking	take	VBG
cord-309871-y17puao2	104	3	into	into	IN
cord-309871-y17puao2	104	4	consideration	consideration	NN
cord-309871-y17puao2	104	5	this	this	DT
cord-309871-y17puao2	104	6	possible	possible	JJ
cord-309871-y17puao2	104	7	role	role	NN
cord-309871-y17puao2	104	8	of	of	IN
cord-309871-y17puao2	104	9	ABCB1	abcb1	NN
cord-309871-y17puao2	104	10	in	in	IN
cord-309871-y17puao2	104	11	the	the	DT
cord-309871-y17puao2	104	12	synergistic	synergistic	JJ
cord-309871-y17puao2	104	13	combination	combination	NN
cord-309871-y17puao2	104	14	of	of	IN
cord-309871-y17puao2	104	15	these	these	DT
cord-309871-y17puao2	104	16	two	two	CD
cord-309871-y17puao2	104	17	drugs	drug	NNS
cord-309871-y17puao2	104	18	,	,	,
cord-309871-y17puao2	104	19	the	the	DT
cord-309871-y17puao2	104	20	question	question	NN
cord-309871-y17puao2	104	21	of	of	IN
cord-309871-y17puao2	104	22	the	the	DT
cord-309871-y17puao2	104	23	modulation	modulation	NN
cord-309871-y17puao2	104	24	of	of	IN
cord-309871-y17puao2	104	25	ABCB1	abcb1	NN
cord-309871-y17puao2	104	26	transport	transport	NN
cord-309871-y17puao2	104	27	could	could	MD
cord-309871-y17puao2	104	28	be	be	VB
cord-309871-y17puao2	104	29	raised	raise	VBN
cord-309871-y17puao2	104	30	for	for	IN
cord-309871-y17puao2	104	31	preventing	prevent	VBG
cord-309871-y17puao2	104	32	risks	risk	NNS
cord-309871-y17puao2	104	33	of	of	IN
cord-309871-y17puao2	104	34	a	a	DT
cord-309871-y17puao2	104	35	lysosomotropic	lysosomotropic	JJ
cord-309871-y17puao2	104	36	effect	effect	NN
cord-309871-y17puao2	104	37	decrease	decrease	NN
cord-309871-y17puao2	104	38	on	on	IN
cord-309871-y17puao2	104	39	virus	virus	NN
cord-309871-y17puao2	104	40	dynamics	dynamic	NNS
cord-309871-y17puao2	104	41	and	and	CC
cord-309871-y17puao2	104	42	of	of	IN
cord-309871-y17puao2	104	43	interindividual	interindividual	JJ
cord-309871-y17puao2	104	44	variability	variability	NN
cord-309871-y17puao2	104	45	in	in	IN
cord-309871-y17puao2	104	46	the	the	DT
cord-309871-y17puao2	104	47	clinical	clinical	JJ
cord-309871-y17puao2	104	48	use	use	NN
cord-309871-y17puao2	104	49	of	of	IN
cord-309871-y17puao2	104	50	this	this	DT
cord-309871-y17puao2	104	51	drug	drug	NN
cord-309871-y17puao2	104	52	combination	combination	NN
cord-309871-y17puao2	104	53	and	and	CC
cord-309871-y17puao2	104	54	with	with	IN
cord-309871-y17puao2	104	55	possible	possible	JJ
cord-309871-y17puao2	104	56	additional	additional	JJ
cord-309871-y17puao2	104	57	drug	drug	NN
cord-309871-y17puao2	104	58	co	co	NN
cord-309871-y17puao2	104	59	-	-	NN
cord-309871-y17puao2	104	60	therapy	therapy	NN
cord-309871-y17puao2	104	61	.	.	.
cord-309871-y17puao2	105	1	These	these	DT
cord-309871-y17puao2	105	2	risks	risk	NNS
cord-309871-y17puao2	105	3	should	should	MD
cord-309871-y17puao2	105	4	be	be	VB
cord-309871-y17puao2	105	5	considered	consider	VBN
cord-309871-y17puao2	105	6	at	at	IN
cord-309871-y17puao2	105	7	both	both	CC
cord-309871-y17puao2	105	8	the	the	DT
cord-309871-y17puao2	105	9	intracellular	intracellular	JJ
cord-309871-y17puao2	105	10	level	level	NN
cord-309871-y17puao2	105	11	and	and	CC
cord-309871-y17puao2	105	12	at	at	IN
cord-309871-y17puao2	105	13	the	the	DT
cord-309871-y17puao2	105	14	drug	drug	NN
cord-309871-y17puao2	105	15	disposition	disposition	NN
cord-309871-y17puao2	105	16	level	level	NN
cord-309871-y17puao2	105	17	where	where	WRB
cord-309871-y17puao2	105	18	ABCB1	ABCB1	NNP
cord-309871-y17puao2	105	19	has	have	VBZ
cord-309871-y17puao2	105	20	been	be	VBN
cord-309871-y17puao2	105	21	extensively	extensively	RB
cord-309871-y17puao2	105	22	reported	report	VBN
cord-309871-y17puao2	105	23	as	as	IN
cord-309871-y17puao2	105	24	mediating	mediate	VBG
cord-309871-y17puao2	105	25	drug	drug	NN
cord-309871-y17puao2	105	26	-	-	HYPH
cord-309871-y17puao2	105	27	drug	drug	NN
cord-309871-y17puao2	105	28	interactions	interaction	NNS
cord-309871-y17puao2	105	29	(	(	-LRB-
cord-309871-y17puao2	105	30	DDI	DDI	NNP
cord-309871-y17puao2	105	31	)	)	-RRB-
cord-309871-y17puao2	105	32	(	(	-LRB-
cord-309871-y17puao2	105	33	52	52	CD
cord-309871-y17puao2	105	34	)	)	-RRB-
cord-309871-y17puao2	105	35	.	.	.
cord-309871-y17puao2	106	1	First	first	RB
cord-309871-y17puao2	106	2	,	,	,
cord-309871-y17puao2	106	3	the	the	DT
cord-309871-y17puao2	106	4	intracellular	intracellular	JJ
cord-309871-y17puao2	106	5	DDI	DDI	NNP
cord-309871-y17puao2	106	6	risk	risk	NN
cord-309871-y17puao2	106	7	can	can	MD
cord-309871-y17puao2	106	8	be	be	VB
cord-309871-y17puao2	106	9	anticipated	anticipate	VBN
cord-309871-y17puao2	106	10	from	from	IN
cord-309871-y17puao2	106	11	previous	previous	JJ
cord-309871-y17puao2	106	12	studies	study	NNS
cord-309871-y17puao2	106	13	showing	show	VBG
cord-309871-y17puao2	106	14	that	that	IN
cord-309871-y17puao2	106	15	lysosomal	lysosomal	JJ
cord-309871-y17puao2	106	16	ABCB1	abcb1	NN
cord-309871-y17puao2	106	17	can	can	MD
cord-309871-y17puao2	106	18	be	be	VB
cord-309871-y17puao2	106	19	a	a	DT
cord-309871-y17puao2	106	20	DDI	DDI	NNP
cord-309871-y17puao2	106	21	target	target	NN
cord-309871-y17puao2	106	22	(	(	-LRB-
cord-309871-y17puao2	106	23	46	46	CD
cord-309871-y17puao2	106	24	,	,	,
cord-309871-y17puao2	106	25	53	53	CD
cord-309871-y17puao2	106	26	)	)	-RRB-
cord-309871-y17puao2	106	27	.	.	.
cord-309871-y17puao2	107	1	In	in	IN
cord-309871-y17puao2	107	2	addition	addition	NN
cord-309871-y17puao2	107	3	to	to	IN
cord-309871-y17puao2	107	4	the	the	DT
cord-309871-y17puao2	107	5	previous	previous	JJ
cord-309871-y17puao2	107	6	MDR	MDR	NNP
cord-309871-y17puao2	107	7	reversal	reversal	NN
cord-309871-y17puao2	107	8	example	example	NN
cord-309871-y17puao2	107	9	,	,	,
cord-309871-y17puao2	107	10	ABCB1mediated	abcb1mediated	JJ
cord-309871-y17puao2	107	11	lysosomal	lysosomal	JJ
cord-309871-y17puao2	107	12	competition	competition	NN
cord-309871-y17puao2	107	13	between	between	IN
cord-309871-y17puao2	107	14	two	two	CD
cord-309871-y17puao2	107	15	weak	weak	JJ
cord-309871-y17puao2	107	16	bases	basis	NNS
cord-309871-y17puao2	107	17	has	have	VBZ
cord-309871-y17puao2	107	18	been	be	VBN
cord-309871-y17puao2	107	19	elegantly	elegantly	RB
cord-309871-y17puao2	107	20	shown	show	VBN
cord-309871-y17puao2	107	21	in	in	IN
cord-309871-y17puao2	107	22	a	a	DT
cord-309871-y17puao2	107	23	study	study	NN
cord-309871-y17puao2	107	24	using	use	VBG
cord-309871-y17puao2	107	25	positron	positron	NN
cord-309871-y17puao2	107	26	emission	emission	NN
cord-309871-y17puao2	107	27	tomography	tomography	NN
cord-309871-y17puao2	107	28	imaging	imaging	NN
cord-309871-y17puao2	107	29	where	where	WRB
cord-309871-y17puao2	107	30	the	the	DT
cord-309871-y17puao2	107	31	radiotracer	radiotracer	NNP
cord-309871-y17puao2	107	32	[	[	-LRB-
cord-309871-y17puao2	107	33	11	11	CD
cord-309871-y17puao2	107	34	C	C	NNP
cord-309871-y17puao2	107	35	]	]	-RRB-
cord-309871-y17puao2	108	1	Ndesmethyl	Ndesmethyl	NNP
cord-309871-y17puao2	108	2	-	-	HYPH
cord-309871-y17puao2	108	3	loperamide	loperamide	NNP
cord-309871-y17puao2	108	4	was	be	VBD
cord-309871-y17puao2	108	5	displaced	displace	VBN
cord-309871-y17puao2	108	6	from	from	IN
cord-309871-y17puao2	108	7	lysosomes	lysosome	NNS
cord-309871-y17puao2	108	8	by	by	IN
cord-309871-y17puao2	108	9	tariquidar	tariquidar	NNP
cord-309871-y17puao2	108	10	and	and	CC
cord-309871-y17puao2	108	11	other	other	JJ
cord-309871-y17puao2	108	12	ABCB1	ABCB1	NNP
cord-309871-y17puao2	108	13	competitors	competitor	NNS
cord-309871-y17puao2	108	14	like	like	IN
cord-309871-y17puao2	108	15	cyclosporine	cyclosporine	NN
cord-309871-y17puao2	108	16	or	or	CC
cord-309871-y17puao2	108	17	verapamil	verapamil	NN
cord-309871-y17puao2	108	18	(	(	-LRB-
cord-309871-y17puao2	108	19	54	54	CD
cord-309871-y17puao2	108	20	)	)	-RRB-
cord-309871-y17puao2	108	21	.	.	.
cord-309871-y17puao2	109	1	Finally	finally	RB
cord-309871-y17puao2	109	2	,	,	,
cord-309871-y17puao2	109	3	current	current	JJ
cord-309871-y17puao2	109	4	pharmacokinetic	pharmacokinetic	JJ
cord-309871-y17puao2	109	5	considerations	consideration	NNS
cord-309871-y17puao2	109	6	indicate	indicate	VBP
cord-309871-y17puao2	109	7	that	that	IN
cord-309871-y17puao2	109	8	these	these	DT
cord-309871-y17puao2	109	9	drugs	drug	NNS
cord-309871-y17puao2	109	10	are	be	VBP
cord-309871-y17puao2	109	11	characterized	characterize	VBN
cord-309871-y17puao2	109	12	by	by	IN
cord-309871-y17puao2	109	13	a	a	DT
cord-309871-y17puao2	109	14	low	low	JJ
cord-309871-y17puao2	109	15	safety	safety	NN
cord-309871-y17puao2	109	16	margin	margin	NN
cord-309871-y17puao2	109	17	and	and	CC
cord-309871-y17puao2	109	18	by	by	IN
cord-309871-y17puao2	109	19	cardiotoxicity	cardiotoxicity	NN
cord-309871-y17puao2	109	20	risks	risk	NNS
cord-309871-y17puao2	109	21	(	(	-LRB-
cord-309871-y17puao2	109	22	55	55	CD
cord-309871-y17puao2	109	23	,	,	,
cord-309871-y17puao2	109	24	56	56	CD
cord-309871-y17puao2	109	25	)	)	-RRB-
cord-309871-y17puao2	109	26	.	.	.
cord-309871-y17puao2	110	1	Therefore	therefore	RB
cord-309871-y17puao2	110	2	,	,	,
cord-309871-y17puao2	110	3	risks	risk	NNS
cord-309871-y17puao2	110	4	of	of	IN
cord-309871-y17puao2	110	5	inter	inter	JJ
cord-309871-y17puao2	110	6	and	and	CC
cord-309871-y17puao2	110	7	intra	intra	JJ
cord-309871-y17puao2	110	8	-	-	JJ
cord-309871-y17puao2	110	9	individual	individual	JJ
cord-309871-y17puao2	110	10	variabilities	variability	NNS
cord-309871-y17puao2	110	11	have	have	VBP
cord-309871-y17puao2	110	12	to	to	TO
cord-309871-y17puao2	110	13	be	be	VB
cord-309871-y17puao2	110	14	considered	consider	VBN
cord-309871-y17puao2	110	15	.	.	.
cord-309871-y17puao2	111	1	Presently	presently	RB
cord-309871-y17puao2	111	2	,	,	,
cord-309871-y17puao2	111	3	no	no	DT
cord-309871-y17puao2	111	4	systemic	systemic	JJ
cord-309871-y17puao2	111	5	pharmacokinetic	pharmacokinetic	JJ
cord-309871-y17puao2	111	6	interactions	interaction	NNS
cord-309871-y17puao2	111	7	have	have	VBP
cord-309871-y17puao2	111	8	been	be	VBN
cord-309871-y17puao2	111	9	observed	observe	VBN
cord-309871-y17puao2	111	10	between	between	IN
cord-309871-y17puao2	111	11	chloroquine	chloroquine	NN
cord-309871-y17puao2	111	12	and	and	CC
cord-309871-y17puao2	111	13	azithromycin	azithromycin	NN
cord-309871-y17puao2	111	14	(	(	-LRB-
cord-309871-y17puao2	111	15	24	24	CD
cord-309871-y17puao2	111	16	)	)	-RRB-
cord-309871-y17puao2	111	17	.	.	.
cord-309871-y17puao2	112	1	Azithromycin	Azithromycin	NNP
cord-309871-y17puao2	112	2	is	be	VBZ
cord-309871-y17puao2	112	3	known	know	VBN
cord-309871-y17puao2	112	4	for	for	IN
cord-309871-y17puao2	112	5	interindividual	interindividual	NNP
cord-309871-y17puao2	112	6	variabilities	variabilities	NNP
cord-309871-y17puao2	112	7	in	in	IN
cord-309871-y17puao2	112	8	drug	drug	NN
cord-309871-y17puao2	112	9	response	response	NN
cord-309871-y17puao2	112	10	and	and	CC
cord-309871-y17puao2	112	11	among	among	IN
cord-309871-y17puao2	112	12	ethnic	ethnic	JJ
cord-309871-y17puao2	112	13	groups	group	NNS
cord-309871-y17puao2	112	14	and	and	CC
cord-309871-y17puao2	112	15	could	could	MD
cord-309871-y17puao2	112	16	be	be	VB
cord-309871-y17puao2	112	17	a	a	DT
cord-309871-y17puao2	112	18	DDI	DDI	NNP
cord-309871-y17puao2	112	19	perpetrator	perpetrator	NN
cord-309871-y17puao2	112	20	candidate	candidate	NN
cord-309871-y17puao2	112	21	.	.	.
cord-309871-y17puao2	113	1	Azithromycin	Azithromycin	NNP
cord-309871-y17puao2	113	2	is	be	VBZ
cord-309871-y17puao2	113	3	not	not	RB
cord-309871-y17puao2	113	4	metabolized	metabolize	VBN
cord-309871-y17puao2	113	5	by	by	IN
cord-309871-y17puao2	113	6	cytochromes	cytochrome	NNS
cord-309871-y17puao2	113	7	P450	P450	NNPS
cord-309871-y17puao2	113	8	and	and	CC
cord-309871-y17puao2	113	9	not	not	RB
cord-309871-y17puao2	113	10	an	an	DT
cord-309871-y17puao2	113	11	inducer	inducer	NN
cord-309871-y17puao2	113	12	/	/	SYM
cord-309871-y17puao2	113	13	inhibitor	inhibitor	NN
cord-309871-y17puao2	113	14	of	of	IN
cord-309871-y17puao2	113	15	these	these	DT
cord-309871-y17puao2	113	16	hepatic	hepatic	JJ
cord-309871-y17puao2	113	17	enzymes	enzyme	NNS
cord-309871-y17puao2	113	18	.	.	.
cord-309871-y17puao2	114	1	The	the	DT
cord-309871-y17puao2	114	2	dominant	dominant	JJ
cord-309871-y17puao2	114	3	azithromycin	azithromycin	NNP
cord-309871-y17puao2	114	4	excretion	excretion	NN
cord-309871-y17puao2	114	5	pathway	pathway	NN
cord-309871-y17puao2	114	6	occurs	occur	VBZ
cord-309871-y17puao2	114	7	at	at	IN
cord-309871-y17puao2	114	8	the	the	DT
cord-309871-y17puao2	114	9	biliary	biliary	JJ
cord-309871-y17puao2	114	10	and	and	CC
cord-309871-y17puao2	114	11	intestinal	intestinal	JJ
cord-309871-y17puao2	114	12	levels	level	NNS
cord-309871-y17puao2	114	13	via	via	IN
cord-309871-y17puao2	114	14	ABCB1	abcb1	NN
cord-309871-y17puao2	115	1	and	and	CC
cord-309871-y17puao2	115	2	ABCC2	ABCC2	NNP
cord-309871-y17puao2	116	1	(	(	-LRB-
cord-309871-y17puao2	116	2	MRP2	MRP2	NNP
cord-309871-y17puao2	116	3	)	)	-RRB-
cord-309871-y17puao2	116	4	active	active	JJ
cord-309871-y17puao2	116	5	transport	transport	NN
cord-309871-y17puao2	116	6	which	which	WDT
cord-309871-y17puao2	116	7	could	could	MD
cord-309871-y17puao2	116	8	represent	represent	VB
cord-309871-y17puao2	116	9	DDI	DDI	NNP
cord-309871-y17puao2	116	10	targets	target	NNS
cord-309871-y17puao2	116	11	(	(	-LRB-
cord-309871-y17puao2	116	12	36	36	CD
cord-309871-y17puao2	116	13	)	)	-RRB-
cord-309871-y17puao2	116	14	.	.	.
cord-309871-y17puao2	117	1	However	however	RB
cord-309871-y17puao2	117	2	,	,	,
cord-309871-y17puao2	117	3	a	a	DT
cord-309871-y17puao2	117	4	few	few	JJ
cord-309871-y17puao2	117	5	and	and	CC
cord-309871-y17puao2	117	6	insignificant	insignificant	JJ
cord-309871-y17puao2	117	7	clinical	clinical	JJ
cord-309871-y17puao2	117	8	DDIs	ddi	NNS
cord-309871-y17puao2	117	9	have	have	VBP
cord-309871-y17puao2	117	10	been	be	VBN
cord-309871-y17puao2	117	11	observed	observe	VBN
cord-309871-y17puao2	117	12	between	between	IN
cord-309871-y17puao2	117	13	azithromycin	azithromycin	NN
cord-309871-y17puao2	117	14	and	and	CC
cord-309871-y17puao2	117	15	co	co	JJ
cord-309871-y17puao2	117	16	-	-	JJ
cord-309871-y17puao2	117	17	prescribed	prescribed	JJ
cord-309871-y17puao2	117	18	drugs	drug	NNS
cord-309871-y17puao2	117	19	(	(	-LRB-
cord-309871-y17puao2	117	20	24	24	CD
cord-309871-y17puao2	117	21	)	)	-RRB-
cord-309871-y17puao2	117	22	.	.	.
cord-309871-y17puao2	118	1	Lastly	lastly	RB
cord-309871-y17puao2	118	2	,	,	,
cord-309871-y17puao2	118	3	the	the	DT
cord-309871-y17puao2	118	4	most	most	RBS
cord-309871-y17puao2	118	5	intriguing	intriguing	JJ
cord-309871-y17puao2	118	6	interpopulation	interpopulation	NN
cord-309871-y17puao2	118	7	variability	variability	NN
cord-309871-y17puao2	118	8	could	could	MD
cord-309871-y17puao2	118	9	result	result	VB
cord-309871-y17puao2	118	10	from	from	IN
cord-309871-y17puao2	118	11	the	the	DT
cord-309871-y17puao2	118	12	azithromycin	azithromycin	NNP
cord-309871-y17puao2	118	13	sensitivity	sensitivity	NN
cord-309871-y17puao2	118	14	to	to	IN
cord-309871-y17puao2	118	15	ABCB1	abcb1	VB
cord-309871-y17puao2	118	16	genetic	genetic	JJ
cord-309871-y17puao2	118	17	polymorphism	polymorphism	NN
cord-309871-y17puao2	118	18	.	.	.
cord-309871-y17puao2	119	1	Two	two	CD
cord-309871-y17puao2	119	2	clinical	clinical	JJ
cord-309871-y17puao2	119	3	studies	study	NNS
cord-309871-y17puao2	119	4	have	have	VBP
cord-309871-y17puao2	119	5	described	describe	VBN
cord-309871-y17puao2	119	6	that	that	IN
cord-309871-y17puao2	119	7	heterozygous	heterozygous	JJ
cord-309871-y17puao2	119	8	and	and	CC
cord-309871-y17puao2	119	9	mutant	mutant	JJ
cord-309871-y17puao2	119	10	ABCB1	ABCB1	NNP
cord-309871-y17puao2	119	11	genes	gene	NNS
cord-309871-y17puao2	119	12	in	in	IN
cord-309871-y17puao2	119	13	Chinese	chinese	JJ
cord-309871-y17puao2	119	14	Han	Han	NNP
cord-309871-y17puao2	119	15	and	and	CC
cord-309871-y17puao2	119	16	Pakistani	pakistani	JJ
cord-309871-y17puao2	119	17	subjects	subject	NNS
cord-309871-y17puao2	119	18	have	have	VBP
cord-309871-y17puao2	119	19	decreased	decrease	VBN
cord-309871-y17puao2	119	20	rate	rate	NN
cord-309871-y17puao2	119	21	and	and	CC
cord-309871-y17puao2	119	22	extent	extent	NN
cord-309871-y17puao2	119	23	of	of	IN
cord-309871-y17puao2	119	24	azithromycin	azithromycin	NN
cord-309871-y17puao2	119	25	absorption	absorption	NN
cord-309871-y17puao2	119	26	when	when	WRB
cord-309871-y17puao2	119	27	compared	compare	VBN
cord-309871-y17puao2	119	28	to	to	IN
cord-309871-y17puao2	119	29	the	the	DT
cord-309871-y17puao2	119	30	wild	wild	JJ
cord-309871-y17puao2	119	31	-	-	HYPH
cord-309871-y17puao2	119	32	type	type	NN
cord-309871-y17puao2	119	33	subjects	subject	NNS
cord-309871-y17puao2	119	34	(	(	-LRB-
cord-309871-y17puao2	119	35	34	34	CD
cord-309871-y17puao2	119	36	,	,	,
cord-309871-y17puao2	119	37	35	35	CD
cord-309871-y17puao2	119	38	)	)	-RRB-
cord-309871-y17puao2	119	39	.	.	.
cord-309871-y17puao2	120	1	This	this	DT
cord-309871-y17puao2	120	2	suggests	suggest	VBZ
cord-309871-y17puao2	120	3	that	that	IN
cord-309871-y17puao2	120	4	the	the	DT
cord-309871-y17puao2	120	5	ABCB1-dependent	ABCB1-dependent	NNP
cord-309871-y17puao2	120	6	effectiveness	effectiveness	NN
cord-309871-y17puao2	120	7	of	of	IN
cord-309871-y17puao2	120	8	azithromycin	azithromycin	NN
cord-309871-y17puao2	120	9	at	at	IN
cord-309871-y17puao2	120	10	the	the	DT
cord-309871-y17puao2	120	11	intracellular	intracellular	JJ
cord-309871-y17puao2	120	12	level	level	NN
cord-309871-y17puao2	120	13	could	could	MD
cord-309871-y17puao2	120	14	be	be	VB
cord-309871-y17puao2	120	15	variable	variable	JJ
cord-309871-y17puao2	120	16	according	accord	VBG
cord-309871-y17puao2	120	17	to	to	IN
cord-309871-y17puao2	120	18	the	the	DT
cord-309871-y17puao2	120	19	patient	patient	NN
cord-309871-y17puao2	120	20	ABCB1	ABCB1	NNP
cord-309871-y17puao2	120	21	genetic	genetic	JJ
cord-309871-y17puao2	120	22	status	status	NN
cord-309871-y17puao2	120	23	.	.	.
cord-309871-y17puao2	121	1	In	in	IN
cord-309871-y17puao2	121	2	conclusion	conclusion	NN
cord-309871-y17puao2	121	3	,	,	,
cord-309871-y17puao2	121	4	we	-PRON-	PRP
cord-309871-y17puao2	121	5	hypothesize	hypothesize	VBP
cord-309871-y17puao2	121	6	that	that	IN
cord-309871-y17puao2	121	7	the	the	DT
cord-309871-y17puao2	121	8	intracellular	intracellular	JJ
cord-309871-y17puao2	121	9	ABCB1	ABCB1	NNP
cord-309871-y17puao2	121	10	may	may	MD
cord-309871-y17puao2	121	11	serve	serve	VB
cord-309871-y17puao2	121	12	as	as	IN
cord-309871-y17puao2	121	13	a	a	DT
cord-309871-y17puao2	121	14	possible	possible	JJ
cord-309871-y17puao2	121	15	new	new	JJ
cord-309871-y17puao2	121	16	target	target	NN
cord-309871-y17puao2	121	17	for	for	IN
cord-309871-y17puao2	121	18	improving	improve	VBG
cord-309871-y17puao2	121	19	the	the	DT
cord-309871-y17puao2	121	20	effects	effect	NNS
cord-309871-y17puao2	121	21	of	of	IN
cord-309871-y17puao2	121	22	the	the	DT
cord-309871-y17puao2	121	23	aminoquinolines	aminoquinoline	NNS
cord-309871-y17puao2	121	24	when	when	WRB
cord-309871-y17puao2	121	25	co	co	NN
cord-309871-y17puao2	121	26	-	-	VBN
cord-309871-y17puao2	121	27	administered	administer	VBN
cord-309871-y17puao2	121	28	with	with	IN
cord-309871-y17puao2	121	29	a	a	DT
cord-309871-y17puao2	121	30	lysosomotropic	lysosomotropic	JJ
cord-309871-y17puao2	121	31	drug	drug	NN
cord-309871-y17puao2	121	32	,	,	,
cord-309871-y17puao2	121	33	such	such	JJ
cord-309871-y17puao2	121	34	as	as	IN
cord-309871-y17puao2	121	35	azithromycin	azithromycin	NNP
cord-309871-y17puao2	121	36	or	or	CC
cord-309871-y17puao2	121	37	ciprofloxacin	ciprofloxacin	NN
cord-309871-y17puao2	121	38	in	in	IN
cord-309871-y17puao2	121	39	COVID-19	COVID-19	NNP
cord-309871-y17puao2	121	40	chemotherapy	chemotherapy	NN
cord-309871-y17puao2	121	41	.	.	.
cord-309871-y17puao2	122	1	In	in	IN
cord-309871-y17puao2	122	2	vitro	vitro	FW
cord-309871-y17puao2	122	3	experiments	experiment	NNS
cord-309871-y17puao2	122	4	could	could	MD
cord-309871-y17puao2	122	5	readily	readily	RB
cord-309871-y17puao2	122	6	confirm	confirm	VB
cord-309871-y17puao2	122	7	or	or	CC
cord-309871-y17puao2	122	8	contradict	contradict	VB
cord-309871-y17puao2	122	9	this	this	DT
cord-309871-y17puao2	122	10	hypothesis	hypothesis	NN
cord-309871-y17puao2	122	11	.	.	.
cord-309871-y17puao2	123	1	The	the	DT
cord-309871-y17puao2	123	2	proposed	propose	VBN
cord-309871-y17puao2	123	3	hypothesis	hypothesis	NN
cord-309871-y17puao2	123	4	might	may	MD
cord-309871-y17puao2	123	5	stimulate	stimulate	VB
cord-309871-y17puao2	123	6	further	further	JJ
cord-309871-y17puao2	123	7	investigations	investigation	NNS
cord-309871-y17puao2	123	8	and	and	CC
cord-309871-y17puao2	123	9	experimental	experimental	JJ
cord-309871-y17puao2	123	10	validation	validation	NN
cord-309871-y17puao2	123	11	for	for	IN
cord-309871-y17puao2	123	12	the	the	DT
cord-309871-y17puao2	123	13	clinical	clinical	JJ
cord-309871-y17puao2	123	14	relevance	relevance	NN
cord-309871-y17puao2	123	15	of	of	IN
cord-309871-y17puao2	123	16	this	this	DT
cord-309871-y17puao2	123	17	possible	possible	JJ
cord-309871-y17puao2	123	18	treatment	treatment	NN
cord-309871-y17puao2	123	19	.	.	.
cord-309871-y17puao2	124	1	Moreover	moreover	RB
cord-309871-y17puao2	124	2	,	,	,
cord-309871-y17puao2	124	3	this	this	DT
cord-309871-y17puao2	124	4	case	case	NN
cord-309871-y17puao2	124	5	example	example	NN
cord-309871-y17puao2	124	6	highlights	highlight	VBZ
cord-309871-y17puao2	124	7	that	that	IN
cord-309871-y17puao2	124	8	molecular	molecular	JJ
cord-309871-y17puao2	124	9	and	and	CC
cord-309871-y17puao2	124	10	cellular	cellular	JJ
cord-309871-y17puao2	124	11	pharmacokinetics	pharmacokinetic	NNS
cord-309871-y17puao2	124	12	should	should	MD
cord-309871-y17puao2	124	13	be	be	VB
cord-309871-y17puao2	124	14	considered	consider	VBN
cord-309871-y17puao2	124	15	in	in	IN
cord-309871-y17puao2	124	16	the	the	DT
cord-309871-y17puao2	124	17	future	future	NN
cord-309871-y17puao2	124	18	for	for	IN
cord-309871-y17puao2	124	19	the	the	DT
cord-309871-y17puao2	124	20	understanding	understanding	NN
cord-309871-y17puao2	124	21	of	of	IN
cord-309871-y17puao2	124	22	drug	drug	NN
cord-309871-y17puao2	124	23	interaction	interaction	NN
cord-309871-y17puao2	124	24	at	at	IN
cord-309871-y17puao2	124	25	the	the	DT
cord-309871-y17puao2	124	26	intracellular	intracellular	JJ
cord-309871-y17puao2	124	27	level	level	NN
cord-309871-y17puao2	124	28	.	.	.
cord-309871-y17puao2	125	1	Postscript	postscript	NN
cord-309871-y17puao2	125	2	.	.	.
cord-309871-y17puao2	126	1	While	while	IN
cord-309871-y17puao2	126	2	this	this	DT
cord-309871-y17puao2	126	3	manuscript	manuscript	NN
cord-309871-y17puao2	126	4	was	be	VBD
cord-309871-y17puao2	126	5	under	under	IN
cord-309871-y17puao2	126	6	review	review	NN
cord-309871-y17puao2	126	7	,	,	,
cord-309871-y17puao2	126	8	a	a	DT
cord-309871-y17puao2	126	9	paper	paper	NN
cord-309871-y17puao2	126	10	describing	describe	VBG
cord-309871-y17puao2	126	11	similar	similar	JJ
cord-309871-y17puao2	126	12	lysosomal	lysosomal	JJ
cord-309871-y17puao2	126	13	accumulation	accumulation	NN
cord-309871-y17puao2	126	14	of	of	IN
cord-309871-y17puao2	126	15	the	the	DT
cord-309871-y17puao2	126	16	two	two	CD
cord-309871-y17puao2	126	17	drugs	drug	NNS
cord-309871-y17puao2	126	18	via	via	IN
cord-309871-y17puao2	126	19	ion	ion	NN
cord-309871-y17puao2	126	20	-	-	HYPH
cord-309871-y17puao2	126	21	trapping	trapping	NN
cord-309871-y17puao2	126	22	mechanism	mechanism	NN
cord-309871-y17puao2	126	23	was	be	VBD
cord-309871-y17puao2	126	24	published	publish	VBN
cord-309871-y17puao2	126	25	(	(	-LRB-
cord-309871-y17puao2	126	26	57	57	CD
cord-309871-y17puao2	126	27	)	)	-RRB-
cord-309871-y17puao2	126	28	.	.	.
cord-309871-y17puao2	127	1	The	the	DT
cord-309871-y17puao2	127	2	author	author	NN
cord-309871-y17puao2	127	3	is	be	VBZ
cord-309871-y17puao2	127	4	very	very	RB
cord-309871-y17puao2	127	5	grateful	grateful	JJ
cord-309871-y17puao2	127	6	to	to	IN
cord-309871-y17puao2	127	7	Dr.	Dr.	NNP
cord-309871-y17puao2	127	8	Fanchon	Fanchon	NNP
cord-309871-y17puao2	127	9	Bourasset	Bourasset	NNP
cord-309871-y17puao2	127	10	and	and	CC
cord-309871-y17puao2	127	11	to	to	IN
cord-309871-y17puao2	127	12	Mrs.	Mrs.	NNP
cord-309871-y17puao2	127	13	Marie	Marie	NNP
cord-309871-y17puao2	127	14	-	-	HYPH
cord-309871-y17puao2	127	15	Christine	Christine	NNP
cord-309871-y17puao2	127	16	Scherrmann	Scherrmann	NNP
cord-309871-y17puao2	127	17	for	for	IN
cord-309871-y17puao2	127	18	editing	editing	NN
cord-309871-y17puao2	127	19	help	help	NN
cord-309871-y17puao2	127	20	.	.	.
cord-309871-y17puao2	128	1	Conflict	conflict	NN
cord-309871-y17puao2	128	2	of	of	IN
cord-309871-y17puao2	128	3	Interest	interest	NN
cord-309871-y17puao2	129	1	The	the	DT
cord-309871-y17puao2	129	2	author	author	NN
cord-309871-y17puao2	129	3	declares	declare	VBZ
cord-309871-y17puao2	129	4	that	that	IN
cord-309871-y17puao2	129	5	he	-PRON-	PRP
cord-309871-y17puao2	129	6	has	have	VBZ
cord-309871-y17puao2	129	7	no	no	DT
cord-309871-y17puao2	129	8	conflict	conflict	NN
cord-309871-y17puao2	129	9	of	of	IN
cord-309871-y17puao2	129	10	interest	interest	NN
cord-309871-y17puao2	129	11	.	.	.
cord-309871-y17puao2	130	1	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-309871-y17puao2	130	2	and	and	CC
cord-309871-y17puao2	130	3	azithromycin	azithromycin	NNP
cord-309871-y17puao2	130	4	as	as	IN
cord-309871-y17puao2	130	5	a	a	DT
cord-309871-y17puao2	130	6	treatment	treatment	NN
cord-309871-y17puao2	130	7	of	of	IN
cord-309871-y17puao2	130	8	COVID-19	covid-19	NN
cord-309871-y17puao2	130	9	:	:	:
cord-309871-y17puao2	130	10	results	result	NNS
cord-309871-y17puao2	130	11	of	of	IN
cord-309871-y17puao2	130	12	an	an	DT
cord-309871-y17puao2	130	13	open	open	JJ
cord-309871-y17puao2	130	14	-	-	HYPH
cord-309871-y17puao2	130	15	label	label	NN
cord-309871-y17puao2	130	16	non	non	JJ
cord-309871-y17puao2	130	17	-	-	JJ
cord-309871-y17puao2	130	18	randomized	randomized	JJ
cord-309871-y17puao2	130	19	clinical	clinical	JJ
cord-309871-y17puao2	130	20	trial	trial	NN
cord-309871-y17puao2	130	21	A	a	DT
cord-309871-y17puao2	130	22	pilot	pilot	NN
cord-309871-y17puao2	130	23	study	study	NN
cord-309871-y17puao2	130	24	of	of	IN
cord-309871-y17puao2	130	25	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	130	26	in	in	IN
cord-309871-y17puao2	130	27	treatment	treatment	NN
cord-309871-y17puao2	130	28	of	of	IN
cord-309871-y17puao2	130	29	patients	patient	NNS
cord-309871-y17puao2	130	30	with	with	IN
cord-309871-y17puao2	130	31	common	common	JJ
cord-309871-y17puao2	130	32	coronavirus	coronavirus	NN
cord-309871-y17puao2	130	33	disease-19	disease-19	,
cord-309871-y17puao2	130	34	(	(	-LRB-
cord-309871-y17puao2	130	35	COVID-19	COVID-19	NNP
cord-309871-y17puao2	130	36	)	)	-RRB-
cord-309871-y17puao2	130	37	Breakthrough	Breakthrough	NNP
cord-309871-y17puao2	131	1	:	:	:
cord-309871-y17puao2	131	2	chloroquine	chloroquine	NN
cord-309871-y17puao2	131	3	phosphate	phosphate	NN
cord-309871-y17puao2	131	4	has	have	VBZ
cord-309871-y17puao2	131	5	shown	show	VBN
cord-309871-y17puao2	131	6	apparent	apparent	JJ
cord-309871-y17puao2	131	7	efficacy	efficacy	NN
cord-309871-y17puao2	131	8	in	in	IN
cord-309871-y17puao2	131	9	treatment	treatment	NN
cord-309871-y17puao2	131	10	of	of	IN
cord-309871-y17puao2	131	11	COVID-19	covid-19	JJ
cord-309871-y17puao2	131	12	associated	associated	JJ
cord-309871-y17puao2	131	13	pneumonia	pneumonia	NN
cord-309871-y17puao2	131	14	in	in	IN
cord-309871-y17puao2	131	15	clinical	clinical	JJ
cord-309871-y17puao2	131	16	studies	study	NNS
cord-309871-y17puao2	132	1	COVID-19	covid-19	VB
cord-309871-y17puao2	132	2	:	:	:
cord-309871-y17puao2	132	3	a	a	DT
cord-309871-y17puao2	132	4	recommendation	recommendation	NN
cord-309871-y17puao2	132	5	to	to	TO
cord-309871-y17puao2	132	6	examine	examine	VB
cord-309871-y17puao2	132	7	the	the	DT
cord-309871-y17puao2	132	8	effect	effect	NN
cord-309871-y17puao2	132	9	of	of	IN
cord-309871-y17puao2	132	10	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	132	11	in	in	IN
cord-309871-y17puao2	132	12	preventing	prevent	VBG
cord-309871-y17puao2	132	13	infection	infection	NN
cord-309871-y17puao2	132	14	and	and	CC
cord-309871-y17puao2	132	15	progression	progression	NN
cord-309871-y17puao2	133	1	COVID-19	covid-19	VB
cord-309871-y17puao2	133	2	?	?	.
cord-309871-y17puao2	134	1	A	a	DT
cord-309871-y17puao2	134	2	rapid	rapid	JJ
cord-309871-y17puao2	134	3	review	review	NN
cord-309871-y17puao2	134	4	.	.	.
cord-309871-y17puao2	135	1	BJGP	BJGP	NNP
cord-309871-y17puao2	135	2	Open	Open	NNP
cord-309871-y17puao2	135	3	.	.	.
cord-309871-y17puao2	136	1	2020	2020	CD
cord-309871-y17puao2	137	1	A	a	DT
cord-309871-y17puao2	137	2	call	call	NN
cord-309871-y17puao2	137	3	for	for	IN
cord-309871-y17puao2	137	4	randomized	randomized	JJ
cord-309871-y17puao2	137	5	controlled	control	VBN
cord-309871-y17puao2	137	6	trials	trial	NNS
cord-309871-y17puao2	137	7	to	to	TO
cord-309871-y17puao2	137	8	test	test	VB
cord-309871-y17puao2	137	9	the	the	DT
cord-309871-y17puao2	137	10	efficacy	efficacy	NN
cord-309871-y17puao2	137	11	of	of	IN
cord-309871-y17puao2	137	12	chloroquine	chloroquine	NNP
cord-309871-y17puao2	137	13	and	and	CC
cord-309871-y17puao2	137	14	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	137	15	as	as	IN
cord-309871-y17puao2	137	16	therapeutics	therapeutic	NNS
cord-309871-y17puao2	137	17	against	against	IN
cord-309871-y17puao2	137	18	novel	novel	JJ
cord-309871-y17puao2	137	19	coronavirus	coronavirus	NN
cord-309871-y17puao2	137	20	disease	disease	NN
cord-309871-y17puao2	137	21	(	(	-LRB-
cord-309871-y17puao2	137	22	COVID-19	COVID-19	NNP
cord-309871-y17puao2	137	23	)	)	-RRB-
cord-309871-y17puao2	137	24	Macrolide	macrolide	JJ
cord-309871-y17puao2	137	25	treatment	treatment	NN
cord-309871-y17puao2	137	26	for	for	IN
cord-309871-y17puao2	137	27	COVID-19	covid-19	NN
cord-309871-y17puao2	137	28	:	:	:
cord-309871-y17puao2	137	29	will	will	MD
cord-309871-y17puao2	137	30	this	this	DT
cord-309871-y17puao2	137	31	be	be	VB
cord-309871-y17puao2	137	32	the	the	DT
cord-309871-y17puao2	137	33	way	way	NN
cord-309871-y17puao2	137	34	forward	forward	RB
cord-309871-y17puao2	137	35	?	?	.
cord-309871-y17puao2	138	1	Clinical	clinical	JJ
cord-309871-y17puao2	138	2	pharmacology	pharmacology	NN
cord-309871-y17puao2	138	3	perspectives	perspective	NNS
cord-309871-y17puao2	138	4	on	on	IN
cord-309871-y17puao2	138	5	the	the	DT
cord-309871-y17puao2	138	6	antiviral	antiviral	JJ
cord-309871-y17puao2	138	7	activity	activity	NN
cord-309871-y17puao2	138	8	of	of	IN
cord-309871-y17puao2	138	9	azithromycin	azithromycin	NN
cord-309871-y17puao2	138	10	and	and	CC
cord-309871-y17puao2	138	11	use	use	NN
cord-309871-y17puao2	138	12	in	in	IN
cord-309871-y17puao2	138	13	COVID-19	COVID-19	NNP
cord-309871-y17puao2	138	14	New	new	JJ
cord-309871-y17puao2	138	15	insights	insight	NNS
cord-309871-y17puao2	138	16	on	on	IN
cord-309871-y17puao2	138	17	the	the	DT
cord-309871-y17puao2	138	18	antiviral	antiviral	JJ
cord-309871-y17puao2	138	19	effects	effect	NNS
cord-309871-y17puao2	138	20	of	of	IN
cord-309871-y17puao2	138	21	chloroquine	chloroquine	NN
cord-309871-y17puao2	138	22	against	against	IN
cord-309871-y17puao2	138	23	coronavirus	coronavirus	NN
cord-309871-y17puao2	138	24	:	:	:
cord-309871-y17puao2	139	1	what	what	WP
cord-309871-y17puao2	139	2	to	to	TO
cord-309871-y17puao2	139	3	expect	expect	VB
cord-309871-y17puao2	139	4	for	for	IN
cord-309871-y17puao2	139	5	COVID-19	covid-19	NN
cord-309871-y17puao2	139	6	?	?	.
cord-309871-y17puao2	140	1	Activity	activity	NN
cord-309871-y17puao2	140	2	of	of	IN
cord-309871-y17puao2	140	3	azithromycin	azithromycin	NN
cord-309871-y17puao2	140	4	(	(	-LRB-
cord-309871-y17puao2	140	5	CP-62,993	CP-62,993	NNP
cord-309871-y17puao2	140	6	)	)	-RRB-
cord-309871-y17puao2	140	7	and	and	CC
cord-309871-y17puao2	140	8	erythromycin	erythromycin	NN
cord-309871-y17puao2	140	9	against	against	IN
cord-309871-y17puao2	140	10	chloroquine	chloroquine	NN
cord-309871-y17puao2	140	11	-	-	HYPH
cord-309871-y17puao2	140	12	sensitive	sensitive	JJ
cord-309871-y17puao2	140	13	and	and	CC
cord-309871-y17puao2	140	14	chloroquine	chloroquine	NN
cord-309871-y17puao2	140	15	-	-	HYPH
cord-309871-y17puao2	140	16	resistant	resistant	JJ
cord-309871-y17puao2	140	17	strains	strain	NNS
cord-309871-y17puao2	140	18	of	of	IN
cord-309871-y17puao2	140	19	plasmodium	plasmodium	NN
cord-309871-y17puao2	140	20	falciparum	falciparum	NN
cord-309871-y17puao2	140	21	in	in	IN
cord-309871-y17puao2	140	22	vitro	vitro	FW
cord-309871-y17puao2	140	23	Treatment	treatment	NN
cord-309871-y17puao2	140	24	of	of	IN
cord-309871-y17puao2	140	25	adults	adult	NNS
cord-309871-y17puao2	140	26	with	with	IN
cord-309871-y17puao2	140	27	acute	acute	JJ
cord-309871-y17puao2	140	28	uncomplicated	uncomplicated	JJ
cord-309871-y17puao2	140	29	malaria	malaria	NN
cord-309871-y17puao2	140	30	with	with	IN
cord-309871-y17puao2	140	31	azithromycin	azithromycin	NN
cord-309871-y17puao2	140	32	and	and	CC
cord-309871-y17puao2	140	33	chloroquine	chloroquine	NN
cord-309871-y17puao2	140	34	in	in	IN
cord-309871-y17puao2	140	35	India	India	NNP
cord-309871-y17puao2	140	36	,	,	,
cord-309871-y17puao2	140	37	Colombia	Colombia	NNP
cord-309871-y17puao2	140	38	,	,	,
cord-309871-y17puao2	140	39	and	and	CC
cord-309871-y17puao2	140	40	Suriname	Suriname	NNP
cord-309871-y17puao2	141	1	In	in	IN
cord-309871-y17puao2	141	2	vivo	vivo	NN
cord-309871-y17puao2	141	3	and	and	CC
cord-309871-y17puao2	141	4	in	in	IN
cord-309871-y17puao2	141	5	vitro	vitro	FW
cord-309871-y17puao2	141	6	antimalarial	antimalarial	JJ
cord-309871-y17puao2	141	7	properties	property	NNS
cord-309871-y17puao2	141	8	of	of	IN
cord-309871-y17puao2	141	9	azithromycin	azithromycin	NN
cord-309871-y17puao2	141	10	-	-	HYPH
cord-309871-y17puao2	141	11	chloroquine	chloroquine	NN
cord-309871-y17puao2	141	12	combinations	combination	NNS
cord-309871-y17puao2	141	13	that	that	WDT
cord-309871-y17puao2	141	14	include	include	VBP
cord-309871-y17puao2	141	15	the	the	DT
cord-309871-y17puao2	141	16	resistance	resistance	NN
cord-309871-y17puao2	141	17	reversal	reversal	NN
cord-309871-y17puao2	141	18	agent	agent	NN
cord-309871-y17puao2	141	19	amlodipine	amlodipine	NN
cord-309871-y17puao2	141	20	Killing	Killing	NNP
cord-309871-y17puao2	141	21	of	of	IN
cord-309871-y17puao2	141	22	Staphylococcus	Staphylococcus	NNP
cord-309871-y17puao2	141	23	aureus	aureus	NN
cord-309871-y17puao2	141	24	in	in	IN
cord-309871-y17puao2	141	25	murine	murine	JJ
cord-309871-y17puao2	141	26	macrophages	macrophage	NNS
cord-309871-y17puao2	141	27	by	by	IN
cord-309871-y17puao2	141	28	chloroquine	chloroquine	NN
cord-309871-y17puao2	141	29	used	use	VBN
cord-309871-y17puao2	141	30	alone	alone	RB
cord-309871-y17puao2	141	31	and	and	CC
cord-309871-y17puao2	141	32	in	in	IN
cord-309871-y17puao2	141	33	combination	combination	NN
cord-309871-y17puao2	141	34	with	with	IN
cord-309871-y17puao2	141	35	ciprofloxacin	ciprofloxacin	NN
cord-309871-y17puao2	141	36	or	or	CC
cord-309871-y17puao2	141	37	azithromycin	azithromycin	NN
cord-309871-y17puao2	141	38	Targeting	target	VBG
cord-309871-y17puao2	141	39	endosomal	endosomal	JJ
cord-309871-y17puao2	141	40	acidification	acidification	NN
cord-309871-y17puao2	141	41	by	by	IN
cord-309871-y17puao2	141	42	chloroquine	chloroquine	NN
cord-309871-y17puao2	141	43	analogs	analog	NNS
cord-309871-y17puao2	141	44	as	as	IN
cord-309871-y17puao2	141	45	a	a	DT
cord-309871-y17puao2	141	46	promising	promising	JJ
cord-309871-y17puao2	141	47	strategy	strategy	NN
cord-309871-y17puao2	141	48	for	for	IN
cord-309871-y17puao2	141	49	the	the	DT
cord-309871-y17puao2	141	50	treatment	treatment	NN
cord-309871-y17puao2	141	51	of	of	IN
cord-309871-y17puao2	141	52	emerging	emerge	VBG
cord-309871-y17puao2	141	53	viral	viral	JJ
cord-309871-y17puao2	141	54	diseases	disease	NNS
cord-309871-y17puao2	141	55	Use	Use	NNP
cord-309871-y17puao2	141	56	of	of	IN
cord-309871-y17puao2	141	57	chloroquine	chloroquine	NN
cord-309871-y17puao2	141	58	in	in	IN
cord-309871-y17puao2	141	59	viral	viral	JJ
cord-309871-y17puao2	141	60	diseases	disease	NNS
cord-309871-y17puao2	141	61	Evaluation	Evaluation	NNP
cord-309871-y17puao2	141	62	of	of	IN
cord-309871-y17puao2	141	63	Ebola	Ebola	NNP
cord-309871-y17puao2	141	64	virus	virus	NN
cord-309871-y17puao2	141	65	inhibitors	inhibitor	NNS
cord-309871-y17puao2	141	66	for	for	IN
cord-309871-y17puao2	141	67	drug	drug	NN
cord-309871-y17puao2	141	68	repurposing	repurpose	VBG
cord-309871-y17puao2	141	69	Effects	effect	NNS
cord-309871-y17puao2	141	70	of	of	IN
cord-309871-y17puao2	141	71	chloroquine	chloroquine	NN
cord-309871-y17puao2	141	72	on	on	IN
cord-309871-y17puao2	141	73	viral	viral	JJ
cord-309871-y17puao2	141	74	infections	infection	NNS
cord-309871-y17puao2	141	75	:	:	:
cord-309871-y17puao2	141	76	an	an	DT
cord-309871-y17puao2	141	77	old	old	JJ
cord-309871-y17puao2	141	78	drug	drug	NN
cord-309871-y17puao2	141	79	against	against	IN
cord-309871-y17puao2	141	80	today	today	NN
cord-309871-y17puao2	141	81	's	's	POS
cord-309871-y17puao2	141	82	diseases	disease	NNS
cord-309871-y17puao2	141	83	?	?	.
cord-309871-y17puao2	142	1	An	an	DT
cord-309871-y17puao2	142	2	evaluation	evaluation	NN
cord-309871-y17puao2	142	3	of	of	IN
cord-309871-y17puao2	142	4	chloroquine	chloroquine	NN
cord-309871-y17puao2	142	5	as	as	IN
cord-309871-y17puao2	142	6	a	a	DT
cord-309871-y17puao2	142	7	broad	broad	RB
cord-309871-y17puao2	142	8	-	-	HYPH
cord-309871-y17puao2	142	9	acting	act	VBG
cord-309871-y17puao2	142	10	antiviral	antiviral	JJ
cord-309871-y17puao2	142	11	against	against	IN
cord-309871-y17puao2	142	12	hand	hand	NN
cord-309871-y17puao2	142	13	,	,	,
cord-309871-y17puao2	142	14	Foot	Foot	NNP
cord-309871-y17puao2	142	15	and	and	CC
cord-309871-y17puao2	142	16	Mouth	Mouth	NNP
cord-309871-y17puao2	142	17	Disease	Disease	NNP
cord-309871-y17puao2	142	18	Remdesivir	Remdesivir	NNP
cord-309871-y17puao2	142	19	and	and	CC
cord-309871-y17puao2	142	20	chloroquine	chloroquine	NN
cord-309871-y17puao2	142	21	effectively	effectively	RB
cord-309871-y17puao2	142	22	inhibit	inhibit	VBP
cord-309871-y17puao2	142	23	the	the	DT
cord-309871-y17puao2	142	24	recently	recently	RB
cord-309871-y17puao2	142	25	emerged	emerge	VBN
cord-309871-y17puao2	142	26	novel	novel	JJ
cord-309871-y17puao2	142	27	coronavirus	coronavirus	NN
cord-309871-y17puao2	142	28	(	(	-LRB-
cord-309871-y17puao2	142	29	2019-nCoV	2019-ncov	CD
cord-309871-y17puao2	142	30	)	)	-RRB-
cord-309871-y17puao2	142	31	in	in	IN
cord-309871-y17puao2	142	32	vitro	vitro	FW
cord-309871-y17puao2	142	33	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-309871-y17puao2	142	34	,	,	,
cord-309871-y17puao2	142	35	a	a	DT
cord-309871-y17puao2	142	36	less	less	RBR
cord-309871-y17puao2	142	37	toxic	toxic	JJ
cord-309871-y17puao2	142	38	derivative	derivative	NN
cord-309871-y17puao2	142	39	of	of	IN
cord-309871-y17puao2	142	40	chloroquine	chloroquine	NN
cord-309871-y17puao2	142	41	,	,	,
cord-309871-y17puao2	142	42	is	be	VBZ
cord-309871-y17puao2	142	43	effective	effective	JJ
cord-309871-y17puao2	142	44	in	in	IN
cord-309871-y17puao2	142	45	inhibiting	inhibit	VBG
cord-309871-y17puao2	142	46	SARS	SARS	NNP
cord-309871-y17puao2	142	47	-	-	HYPH
cord-309871-y17puao2	142	48	CoV-2	CoV-2	NNP
cord-309871-y17puao2	142	49	infection	infection	NN
cord-309871-y17puao2	143	1	in	in	IN
cord-309871-y17puao2	143	2	vitro	vitro	FW
cord-309871-y17puao2	144	1	In	in	IN
cord-309871-y17puao2	144	2	vitro	vitro	FW
cord-309871-y17puao2	144	3	antiviral	antiviral	JJ
cord-309871-y17puao2	144	4	activity	activity	NN
cord-309871-y17puao2	144	5	and	and	CC
cord-309871-y17puao2	144	6	projection	projection	NN
cord-309871-y17puao2	144	7	of	of	IN
cord-309871-y17puao2	144	8	optimized	optimize	VBN
cord-309871-y17puao2	144	9	dosing	dosing	NN
cord-309871-y17puao2	144	10	design	design	NN
cord-309871-y17puao2	144	11	of	of	IN
cord-309871-y17puao2	144	12	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	144	13	for	for	IN
cord-309871-y17puao2	144	14	the	the	DT
cord-309871-y17puao2	144	15	treatment	treatment	NN
cord-309871-y17puao2	144	16	of	of	IN
cord-309871-y17puao2	144	17	severe	severe	JJ
cord-309871-y17puao2	144	18	acute	acute	JJ
cord-309871-y17puao2	144	19	respiratory	respiratory	JJ
cord-309871-y17puao2	144	20	syndrome	syndrome	NN
cord-309871-y17puao2	144	21	coronavirus	coronavirus	NN
cord-309871-y17puao2	144	22	2	2	CD
cord-309871-y17puao2	145	1	(	(	-LRB-
cord-309871-y17puao2	145	2	SARS	SARS	NNP
cord-309871-y17puao2	145	3	-	-	HYPH
cord-309871-y17puao2	145	4	CoV-2	CoV-2	NNP
cord-309871-y17puao2	145	5	)	)	-RRB-
cord-309871-y17puao2	146	1	Optimizing	optimize	VBG
cord-309871-y17puao2	146	2	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	146	3	dosing	dose	VBG
cord-309871-y17puao2	146	4	for	for	IN
cord-309871-y17puao2	146	5	patients	patient	NNS
cord-309871-y17puao2	146	6	with	with	IN
cord-309871-y17puao2	146	7	COVID-19	COVID-19	NNP
cord-309871-y17puao2	146	8	:	:	:
cord-309871-y17puao2	146	9	an	an	DT
cord-309871-y17puao2	146	10	integrative	integrative	JJ
cord-309871-y17puao2	146	11	modeling	modeling	NN
cord-309871-y17puao2	146	12	approach	approach	NN
cord-309871-y17puao2	146	13	for	for	IN
cord-309871-y17puao2	146	14	effective	effective	JJ
cord-309871-y17puao2	146	15	drug	drug	NN
cord-309871-y17puao2	146	16	repurposing	repurpose	VBG
cord-309871-y17puao2	146	17	Lysosomes	Lysosomes	NNP
cord-309871-y17puao2	146	18	as	as	IN
cord-309871-y17puao2	146	19	a	a	DT
cord-309871-y17puao2	146	20	therapeutic	therapeutic	JJ
cord-309871-y17puao2	146	21	target	target	NN
cord-309871-y17puao2	146	22	Steady	steady	JJ
cord-309871-y17puao2	146	23	-	-	HYPH
cord-309871-y17puao2	146	24	state	state	NN
cord-309871-y17puao2	146	25	pharmacokinetics	pharmacokinetic	NNS
cord-309871-y17puao2	146	26	of	of	IN
cord-309871-y17puao2	146	27	hydroxychloroquine	hydroxychloroquine	NNP
cord-309871-y17puao2	146	28	in	in	IN
cord-309871-y17puao2	146	29	patients	patient	NNS
cord-309871-y17puao2	146	30	with	with	IN
cord-309871-y17puao2	146	31	cutaneous	cutaneous	JJ
cord-309871-y17puao2	146	32	lupus	lupus	NN
cord-309871-y17puao2	146	33	erythematosus	erythematosus	NN
cord-309871-y17puao2	146	34	Azithromycin	Azithromycin	NNP
cord-309871-y17puao2	146	35	plus	plus	CC
cord-309871-y17puao2	146	36	chloroquine	chloroquine	NN
cord-309871-y17puao2	146	37	:	:	:
cord-309871-y17puao2	146	38	combination	combination	NN
cord-309871-y17puao2	146	39	therapy	therapy	NN
cord-309871-y17puao2	146	40	for	for	IN
cord-309871-y17puao2	146	41	protection	protection	NN
cord-309871-y17puao2	146	42	against	against	IN
cord-309871-y17puao2	146	43	malaria	malaria	NN
cord-309871-y17puao2	146	44	and	and	CC
cord-309871-y17puao2	146	45	sexually	sexually	RB
cord-309871-y17puao2	146	46	transmitted	transmit	VBN
cord-309871-y17puao2	146	47	infections	infection	NNS
cord-309871-y17puao2	146	48	in	in	IN
cord-309871-y17puao2	146	49	pregnancy	pregnancy	NN
cord-309871-y17puao2	146	50	Development	Development	NNP
cord-309871-y17puao2	146	51	of	of	IN
cord-309871-y17puao2	146	52	a	a	DT
cord-309871-y17puao2	146	53	population	population	NN
cord-309871-y17puao2	146	54	pharmacokinetic	pharmacokinetic	JJ
cord-309871-y17puao2	146	55	model	model	NN
cord-309871-y17puao2	146	56	to	to	TO
cord-309871-y17puao2	146	57	describe	describe	VB
cord-309871-y17puao2	146	58	azithromycin	azithromycin	NNP
cord-309871-y17puao2	146	59	whole	whole	JJ
cord-309871-y17puao2	146	60	-	-	HYPH
cord-309871-y17puao2	146	61	blood	blood	NN
cord-309871-y17puao2	146	62	and	and	CC
cord-309871-y17puao2	146	63	plasma	plasma	NN
cord-309871-y17puao2	146	64	concentrations	concentration	NNS
cord-309871-y17puao2	146	65	over	over	IN
cord-309871-y17puao2	146	66	time	time	NN
cord-309871-y17puao2	146	67	in	in	IN
cord-309871-y17puao2	146	68	healthy	healthy	JJ
cord-309871-y17puao2	146	69	subjects	subject	NNS
cord-309871-y17puao2	147	1	Azithromycin	Azithromycin	NNP
cord-309871-y17puao2	147	2	and	and	CC
cord-309871-y17puao2	147	3	ciprofloxacin	ciprofloxacin	NN
cord-309871-y17puao2	147	4	have	have	VBP
cord-309871-y17puao2	147	5	a	a	DT
cord-309871-y17puao2	147	6	chloroquine	chloroquine	NN
cord-309871-y17puao2	147	7	-	-	HYPH
cord-309871-y17puao2	147	8	like	like	JJ
cord-309871-y17puao2	147	9	effect	effect	NN
cord-309871-y17puao2	147	10	on	on	IN
cord-309871-y17puao2	147	11	respiratory	respiratory	JJ
cord-309871-y17puao2	147	12	epithelial	epithelial	JJ
cord-309871-y17puao2	147	13	cells	cell	NNS
cord-309871-y17puao2	148	1	Cationic	cationic	JJ
cord-309871-y17puao2	148	2	amphiphilic	amphiphilic	JJ
cord-309871-y17puao2	148	3	drugs	drug	NNS
cord-309871-y17puao2	148	4	cause	cause	VBP
cord-309871-y17puao2	148	5	a	a	DT
cord-309871-y17puao2	148	6	marked	marked	JJ
cord-309871-y17puao2	148	7	expansion	expansion	NN
cord-309871-y17puao2	148	8	of	of	IN
cord-309871-y17puao2	148	9	apparent	apparent	JJ
cord-309871-y17puao2	148	10	lysosomal	lysosomal	JJ
cord-309871-y17puao2	148	11	volume	volume	NN
cord-309871-y17puao2	148	12	:	:	:
cord-309871-y17puao2	148	13	implications	implication	NNS
cord-309871-y17puao2	148	14	for	for	IN
cord-309871-y17puao2	148	15	an	an	DT
cord-309871-y17puao2	148	16	intracellular	intracellular	JJ
cord-309871-y17puao2	148	17	distribution	distribution	NN
cord-309871-y17puao2	148	18	-	-	HYPH
cord-309871-y17puao2	148	19	based	base	VBN
cord-309871-y17puao2	148	20	drug	drug	NN
cord-309871-y17puao2	148	21	interaction	interaction	NN
cord-309871-y17puao2	148	22	Lysosome	Lysosome	NNP
cord-309871-y17puao2	148	23	membrane	membrane	NN
cord-309871-y17puao2	148	24	permeabilization	permeabilization	NN
cord-309871-y17puao2	148	25	and	and	CC
cord-309871-y17puao2	148	26	disruption	disruption	NN
cord-309871-y17puao2	148	27	of	of	IN
cord-309871-y17puao2	148	28	the	the	DT
cord-309871-y17puao2	148	29	molecular	molecular	JJ
cord-309871-y17puao2	148	30	target	target	NN
cord-309871-y17puao2	148	31	of	of	IN
cord-309871-y17puao2	148	32	rapamycin	rapamycin	NNP
cord-309871-y17puao2	149	1	(	(	-LRB-
cord-309871-y17puao2	149	2	mTOR)-lysosome	mTOR)-lysosome	NNP
cord-309871-y17puao2	149	3	interaction	interaction	NN
cord-309871-y17puao2	149	4	are	be	VBP
cord-309871-y17puao2	149	5	associated	associate	VBN
cord-309871-y17puao2	149	6	with	with	IN
cord-309871-y17puao2	149	7	the	the	DT
cord-309871-y17puao2	149	8	inhibition	inhibition	NN
cord-309871-y17puao2	149	9	of	of	IN
cord-309871-y17puao2	149	10	lung	lung	NN
cord-309871-y17puao2	149	11	cancer	cancer	NN
cord-309871-y17puao2	149	12	cell	cell	NN
cord-309871-y17puao2	149	13	proliferation	proliferation	NN
cord-309871-y17puao2	149	14	by	by	IN
cord-309871-y17puao2	149	15	a	a	DT
cord-309871-y17puao2	149	16	chloroquinoline	chloroquinoline	NN
cord-309871-y17puao2	149	17	analog	analog	NN
cord-309871-y17puao2	149	18	Subcellular	Subcellular	NNP
cord-309871-y17puao2	149	19	distribution	distribution	NN
cord-309871-y17puao2	149	20	of	of	IN
cord-309871-y17puao2	149	21	azithromycin	azithromycin	NNP
cord-309871-y17puao2	149	22	and	and	CC
cord-309871-y17puao2	149	23	clarithromycin	clarithromycin	NNS
cord-309871-y17puao2	149	24	in	in	IN
cord-309871-y17puao2	149	25	rat	rat	NN
cord-309871-y17puao2	149	26	alveolar	alveolar	NN
cord-309871-y17puao2	149	27	macrophages	macrophage	NNS
cord-309871-y17puao2	149	28	(	(	-LRB-
cord-309871-y17puao2	149	29	NR8383	nr8383	NN
cord-309871-y17puao2	149	30	)	)	-RRB-
cord-309871-y17puao2	149	31	in	in	IN
cord-309871-y17puao2	149	32	vitro	vitro	FW
cord-309871-y17puao2	149	33	Differences	difference	NNS
cord-309871-y17puao2	149	34	in	in	IN
cord-309871-y17puao2	149	35	assessment	assessment	NN
cord-309871-y17puao2	149	36	of	of	IN
cord-309871-y17puao2	149	37	macrolide	macrolide	JJ
cord-309871-y17puao2	149	38	interaction	interaction	NN
cord-309871-y17puao2	149	39	with	with	IN
cord-309871-y17puao2	149	40	human	human	JJ
cord-309871-y17puao2	149	41	MDR1	MDR1	NNP
cord-309871-y17puao2	150	1	(	(	-LRB-
cord-309871-y17puao2	150	2	ABCB1	ABCB1	NNP
cord-309871-y17puao2	150	3	,	,	,
cord-309871-y17puao2	150	4	P	p	NN
cord-309871-y17puao2	150	5	-	-	HYPH
cord-309871-y17puao2	150	6	gp	gp	NN
cord-309871-y17puao2	150	7	)	)	-RRB-
cord-309871-y17puao2	150	8	using	use	VBG
cord-309871-y17puao2	150	9	rhodamine-123	rhodamine-123	JJ
cord-309871-y17puao2	150	10	efflux	efflux	NN
cord-309871-y17puao2	150	11	,	,	,
cord-309871-y17puao2	150	12	ATPase	ATPase	NNP
cord-309871-y17puao2	150	13	activity	activity	NN
cord-309871-y17puao2	150	14	and	and	CC
cord-309871-y17puao2	150	15	cellular	cellular	JJ
cord-309871-y17puao2	150	16	accumulation	accumulation	NN
cord-309871-y17puao2	151	1	assays	assays	NNP
cord-309871-y17puao2	152	1	Quantitative	quantitative	JJ
cord-309871-y17puao2	152	2	analysis	analysis	NN
cord-309871-y17puao2	152	3	of	of	IN
cord-309871-y17puao2	152	4	gentamicin	gentamicin	NN
cord-309871-y17puao2	152	5	,	,	,
cord-309871-y17puao2	152	6	azithromycin	azithromycin	NN
cord-309871-y17puao2	152	7	,	,	,
cord-309871-y17puao2	152	8	telithromycin	telithromycin	NN
cord-309871-y17puao2	152	9	,	,	,
cord-309871-y17puao2	152	10	ciprofloxacin	ciprofloxacin	NN
cord-309871-y17puao2	152	11	,	,	,
cord-309871-y17puao2	152	12	moxifloxacin	moxifloxacin	NNS
cord-309871-y17puao2	152	13	,	,	,
cord-309871-y17puao2	152	14	and	and	CC
cord-309871-y17puao2	152	15	oritavancin	oritavancin	NNP
cord-309871-y17puao2	152	16	(	(	-LRB-
cord-309871-y17puao2	152	17	LY333328	ly333328	NN
cord-309871-y17puao2	152	18	)	)	-RRB-
cord-309871-y17puao2	152	19	activities	activity	NNS
cord-309871-y17puao2	152	20	against	against	IN
cord-309871-y17puao2	152	21	intracellular	intracellular	JJ
cord-309871-y17puao2	152	22	Staphylococcus	Staphylococcus	NNP
cord-309871-y17puao2	152	23	aureus	aureus	NN
cord-309871-y17puao2	152	24	in	in	IN
cord-309871-y17puao2	152	25	mouse	mouse	NN
cord-309871-y17puao2	152	26	J774	J774	NNS
cord-309871-y17puao2	152	27	macrophages	macrophage	NNS
cord-309871-y17puao2	153	1	The	the	DT
cord-309871-y17puao2	153	2	effect	effect	NN
cord-309871-y17puao2	153	3	of	of	IN
cord-309871-y17puao2	153	4	azithromycin	azithromycin	NN
cord-309871-y17puao2	153	5	on	on	IN
cord-309871-y17puao2	153	6	ivermectin	ivermectin	NNP
cord-309871-y17puao2	153	7	pharmacokinetics	pharmacokinetics	NNP
cord-309871-y17puao2	153	8	-	-	:
cord-309871-y17puao2	153	9	a	a	DT
cord-309871-y17puao2	153	10	population	population	NN
cord-309871-y17puao2	153	11	pharmacokinetic	pharmacokinetic	JJ
cord-309871-y17puao2	153	12	model	model	NN
cord-309871-y17puao2	153	13	analysis	analysis	NN
cord-309871-y17puao2	153	14	Influence	influence	NN
cord-309871-y17puao2	153	15	of	of	IN
cord-309871-y17puao2	153	16	ABCB1	ABCB1	NNP
cord-309871-y17puao2	153	17	gene	gene	NN
cord-309871-y17puao2	153	18	polymorphisms	polymorphism	NNS
cord-309871-y17puao2	153	19	on	on	IN
cord-309871-y17puao2	153	20	the	the	DT
cord-309871-y17puao2	153	21	pharmacokinetics	pharmacokinetic	NNS
cord-309871-y17puao2	153	22	of	of	IN
cord-309871-y17puao2	153	23	azithromycin	azithromycin	NNP
cord-309871-y17puao2	153	24	among	among	IN
cord-309871-y17puao2	153	25	healthy	healthy	JJ
cord-309871-y17puao2	153	26	Chinese	chinese	JJ
cord-309871-y17puao2	153	27	Han	Han	NNP
cord-309871-y17puao2	153	28	ethnic	ethnic	JJ
cord-309871-y17puao2	153	29	subjects	subject	NNS
cord-309871-y17puao2	154	1	The	the	DT
cord-309871-y17puao2	154	2	effect	effect	NN
cord-309871-y17puao2	154	3	of	of	IN
cord-309871-y17puao2	154	4	gender	gender	NN
cord-309871-y17puao2	154	5	and	and	CC
cord-309871-y17puao2	154	6	ABCB1	abcb1	NN
cord-309871-y17puao2	154	7	gene	gene	NN
cord-309871-y17puao2	154	8	polymorphism	polymorphism	NN
cord-309871-y17puao2	154	9	on	on	IN
cord-309871-y17puao2	154	10	the	the	DT
cord-309871-y17puao2	154	11	pharmacokinetics	pharmacokinetic	NNS
cord-309871-y17puao2	154	12	of	of	IN
cord-309871-y17puao2	154	13	azithromycin	azithromycin	NNP
cord-309871-y17puao2	154	14	in	in	IN
cord-309871-y17puao2	154	15	healthy	healthy	JJ
cord-309871-y17puao2	154	16	male	male	JJ
cord-309871-y17puao2	154	17	and	and	CC
cord-309871-y17puao2	154	18	female	female	JJ
cord-309871-y17puao2	154	19	Pakistani	pakistani	JJ
cord-309871-y17puao2	154	20	subjects	subject	NNS
cord-309871-y17puao2	155	1	Possible	possible	JJ
cord-309871-y17puao2	155	2	involvement	involvement	NN
cord-309871-y17puao2	155	3	of	of	IN
cord-309871-y17puao2	155	4	the	the	DT
cord-309871-y17puao2	155	5	drug	drug	NN
cord-309871-y17puao2	155	6	transporters	transporter	NNS
cord-309871-y17puao2	155	7	P	p	NN
cord-309871-y17puao2	155	8	glycoprotein	glycoprotein	NN
cord-309871-y17puao2	155	9	and	and	CC
cord-309871-y17puao2	155	10	multidrug	multidrug	NN
cord-309871-y17puao2	155	11	resistance	resistance	NN
cord-309871-y17puao2	155	12	-	-	HYPH
cord-309871-y17puao2	155	13	associated	associate	VBN
cord-309871-y17puao2	155	14	protein	protein	NN
cord-309871-y17puao2	155	15	Mrp2	Mrp2	NNP
cord-309871-y17puao2	155	16	in	in	IN
cord-309871-y17puao2	155	17	disposition	disposition	NN
cord-309871-y17puao2	155	18	of	of	IN
cord-309871-y17puao2	155	19	azithromycin	azithromycin	NNP
cord-309871-y17puao2	155	20	P	p	NN
cord-309871-y17puao2	155	21	-	-	HYPH
cord-309871-y17puao2	155	22	glycoprotein	glycoprotein	NN
cord-309871-y17puao2	155	23	ABCB1	abcb1	NN
cord-309871-y17puao2	155	24	:	:	:
cord-309871-y17puao2	155	25	a	a	DT
cord-309871-y17puao2	155	26	major	major	JJ
cord-309871-y17puao2	155	27	player	player	NN
cord-309871-y17puao2	155	28	in	in	IN
cord-309871-y17puao2	155	29	drug	drug	NN
cord-309871-y17puao2	155	30	handling	handling	NN
cord-309871-y17puao2	155	31	by	by	IN
cord-309871-y17puao2	155	32	mammals	mammal	NNS
cord-309871-y17puao2	155	33	Intracellular	Intracellular	NNP
cord-309871-y17puao2	155	34	trafficking	trafficking	NN
cord-309871-y17puao2	155	35	of	of	IN
cord-309871-y17puao2	155	36	P	p	NN
cord-309871-y17puao2	155	37	-	-	HYPH
cord-309871-y17puao2	155	38	glycoprotein	glycoprotein	NN
cord-309871-y17puao2	155	39	Revealing	reveal	VBG
cord-309871-y17puao2	155	40	the	the	DT
cord-309871-y17puao2	155	41	fate	fate	NN
cord-309871-y17puao2	155	42	of	of	IN
cord-309871-y17puao2	155	43	cell	cell	NN
cord-309871-y17puao2	155	44	surface	surface	NN
cord-309871-y17puao2	155	45	human	human	NN
cord-309871-y17puao2	155	46	P	p	NN
cord-309871-y17puao2	155	47	-	-	HYPH
cord-309871-y17puao2	155	48	glycoprotein	glycoprotein	NN
cord-309871-y17puao2	155	49	(	(	-LRB-
cord-309871-y17puao2	155	50	ABCB1	ABCB1	NNP
cord-309871-y17puao2	155	51	)	)	-RRB-
cord-309871-y17puao2	155	52	:	:	:
cord-309871-y17puao2	155	53	the	the	DT
cord-309871-y17puao2	155	54	lysosomal	lysosomal	JJ
cord-309871-y17puao2	155	55	degradation	degradation	NN
cord-309871-y17puao2	155	56	pathway	pathway	NN
cord-309871-y17puao2	155	57	Comparison	comparison	NN
cord-309871-y17puao2	155	58	of	of	IN
cord-309871-y17puao2	155	59	MDCK	MDCK	NNP
cord-309871-y17puao2	155	60	-	-	HYPH
cord-309871-y17puao2	155	61	MDR1	MDR1	NNP
cord-309871-y17puao2	155	62	and	and	CC
cord-309871-y17puao2	155	63	Caco-2	Caco-2	NNP
cord-309871-y17puao2	155	64	cell	cell	NN
cord-309871-y17puao2	155	65	based	base	VBN
cord-309871-y17puao2	155	66	permeability	permeability	NN
cord-309871-y17puao2	155	67	assays	assay	NNS
cord-309871-y17puao2	155	68	for	for	IN
cord-309871-y17puao2	155	69	anti	anti	JJ
cord-309871-y17puao2	155	70	-	-	JJ
cord-309871-y17puao2	155	71	malarial	malarial	JJ
cord-309871-y17puao2	155	72	drug	drug	NN
cord-309871-y17puao2	155	73	screening	screening	NN
cord-309871-y17puao2	155	74	and	and	CC
cord-309871-y17puao2	155	75	drug	drug	NN
cord-309871-y17puao2	155	76	investigations	investigation	NNS
cord-309871-y17puao2	156	1	Ranking	rank	VBG
cord-309871-y17puao2	156	2	of	of	IN
cord-309871-y17puao2	156	3	P	p	NN
cord-309871-y17puao2	156	4	-	-	HYPH
cord-309871-y17puao2	156	5	glycoprotein	glycoprotein	NN
cord-309871-y17puao2	156	6	substrates	substrate	NNS
cord-309871-y17puao2	156	7	and	and	CC
cord-309871-y17puao2	156	8	inhibitors	inhibitor	NNS
cord-309871-y17puao2	156	9	by	by	IN
cord-309871-y17puao2	156	10	a	a	DT
cord-309871-y17puao2	156	11	calcein	calcein	NNP
cord-309871-y17puao2	156	12	-	-	HYPH
cord-309871-y17puao2	156	13	AM	AM	NNP
cord-309871-y17puao2	156	14	fluorometry	fluorometry	NN
cord-309871-y17puao2	156	15	screening	screening	NN
cord-309871-y17puao2	156	16	assay	assay	NN
cord-309871-y17puao2	156	17	.	.	.
cord-309871-y17puao2	157	1	Anti	anti	JJ
cord-309871-y17puao2	157	2	-	-	NNP
cord-309871-y17puao2	157	3	Cancer	Cancer	NNP
cord-309871-y17puao2	157	4	Drugs	drug	NNS
cord-309871-y17puao2	157	5	Atovaquone	Atovaquone	NNP
cord-309871-y17puao2	157	6	and	and	CC
cord-309871-y17puao2	157	7	quinine	quinine	NN
cord-309871-y17puao2	157	8	antimalarials	antimalarial	NNS
cord-309871-y17puao2	157	9	inhibit	inhibit	VBP
cord-309871-y17puao2	157	10	ATP	ATP	NNP
cord-309871-y17puao2	157	11	binding	bind	VBG
cord-309871-y17puao2	157	12	cassette	cassette	NN
cord-309871-y17puao2	157	13	transporter	transporter	NN
cord-309871-y17puao2	157	14	activity	activity	NN
cord-309871-y17puao2	158	1	The	the	DT
cord-309871-y17puao2	158	2	potential	potential	JJ
cord-309871-y17puao2	158	3	inhibitory	inhibitory	JJ
cord-309871-y17puao2	158	4	effect	effect	NN
cord-309871-y17puao2	158	5	of	of	IN
cord-309871-y17puao2	158	6	antiparasitic	antiparasitic	JJ
cord-309871-y17puao2	158	7	drugs	drug	NNS
cord-309871-y17puao2	158	8	and	and	CC
cord-309871-y17puao2	158	9	natural	natural	JJ
cord-309871-y17puao2	158	10	products	product	NNS
cord-309871-y17puao2	158	11	on	on	IN
cord-309871-y17puao2	158	12	P	p	NN
cord-309871-y17puao2	158	13	-	-	HYPH
cord-309871-y17puao2	158	14	glycoprotein	glycoprotein	NN
cord-309871-y17puao2	158	15	mediated	mediate	VBN
cord-309871-y17puao2	158	16	efflux	efflux	NN
cord-309871-y17puao2	158	17	Digoxin	digoxin	NN
cord-309871-y17puao2	158	18	-	-	HYPH
cord-309871-y17puao2	158	19	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	158	20	interaction	interaction	NN
cord-309871-y17puao2	158	21	?	?	.
cord-309871-y17puao2	159	1	A	a	DT
cord-309871-y17puao2	159	2	study	study	NN
cord-309871-y17puao2	159	3	of	of	IN
cord-309871-y17puao2	159	4	the	the	DT
cord-309871-y17puao2	159	5	pharmacokinetics	pharmacokinetic	NNS
cord-309871-y17puao2	159	6	of	of	IN
cord-309871-y17puao2	159	7	azithromycin	azithromycin	NNP
cord-309871-y17puao2	159	8	and	and	CC
cord-309871-y17puao2	159	9	nelfinavir	nelfinavir	NNP
cord-309871-y17puao2	159	10	when	when	WRB
cord-309871-y17puao2	159	11	coadministered	coadministere	VBN
cord-309871-y17puao2	159	12	in	in	IN
cord-309871-y17puao2	159	13	healthy	healthy	JJ
cord-309871-y17puao2	159	14	volunteers	volunteer	NNS
cord-309871-y17puao2	159	15	P	p	NN
cord-309871-y17puao2	159	16	-	-	HYPH
cord-309871-y17puao2	159	17	glycoprotein	glycoprotein	NN
cord-309871-y17puao2	159	18	mediates	mediate	VBZ
cord-309871-y17puao2	159	19	drug	drug	NN
cord-309871-y17puao2	159	20	resistance	resistance	NN
cord-309871-y17puao2	159	21	via	via	IN
cord-309871-y17puao2	159	22	a	a	DT
cord-309871-y17puao2	159	23	novel	novel	JJ
cord-309871-y17puao2	159	24	mechanism	mechanism	NN
cord-309871-y17puao2	159	25	involving	involve	VBG
cord-309871-y17puao2	159	26	lysosomal	lysosomal	JJ
cord-309871-y17puao2	159	27	sequestration	sequestration	NN
cord-309871-y17puao2	159	28	Lysosomal	Lysosomal	NNP
cord-309871-y17puao2	159	29	membrane	membrane	NN
cord-309871-y17puao2	159	30	permeabilization	permeabilization	NN
cord-309871-y17puao2	159	31	and	and	CC
cord-309871-y17puao2	159	32	cell	cell	NN
cord-309871-y17puao2	159	33	death	death	NN
cord-309871-y17puao2	160	1	Lysosomal	Lysosomal	NNP
cord-309871-y17puao2	160	2	sequestration	sequestration	NN
cord-309871-y17puao2	160	3	(	(	-LRB-
cord-309871-y17puao2	160	4	trapping	trap	VBG
cord-309871-y17puao2	160	5	)	)	-RRB-
cord-309871-y17puao2	160	6	of	of	IN
cord-309871-y17puao2	160	7	lipophilic	lipophilic	JJ
cord-309871-y17puao2	160	8	amine	amine	NN
cord-309871-y17puao2	160	9	(	(	-LRB-
cord-309871-y17puao2	160	10	cationic	cationic	JJ
cord-309871-y17puao2	160	11	amphiphilic	amphiphilic	JJ
cord-309871-y17puao2	160	12	)	)	-RRB-
cord-309871-y17puao2	160	13	drugs	drug	NNS
cord-309871-y17puao2	160	14	in	in	IN
cord-309871-y17puao2	160	15	immortalized	immortalize	VBN
cord-309871-y17puao2	160	16	human	human	JJ
cord-309871-y17puao2	160	17	hepatocytes	hepatocyte	NNS
cord-309871-y17puao2	160	18	(	(	-LRB-
cord-309871-y17puao2	160	19	Fa2N-4	Fa2N-4	NNP
cord-309871-y17puao2	160	20	cells	cell	NNS
cord-309871-y17puao2	160	21	)	)	-RRB-
cord-309871-y17puao2	161	1	Impairment	impairment	NN
cord-309871-y17puao2	161	2	of	of	IN
cord-309871-y17puao2	161	3	lysosomal	lysosomal	JJ
cord-309871-y17puao2	161	4	functions	function	NNS
cord-309871-y17puao2	161	5	by	by	IN
cord-309871-y17puao2	161	6	azithromycin	azithromycin	NN
cord-309871-y17puao2	161	7	and	and	CC
cord-309871-y17puao2	161	8	chloroquine	chloroquine	NN
cord-309871-y17puao2	161	9	contributes	contribute	VBZ
cord-309871-y17puao2	161	10	to	to	IN
cord-309871-y17puao2	161	11	anti	anti	JJ
cord-309871-y17puao2	161	12	-	-	JJ
cord-309871-y17puao2	161	13	inflammatory	inflammatory	JJ
cord-309871-y17puao2	161	14	phenotype	phenotype	NN
cord-309871-y17puao2	161	15	Cellular	cellular	JJ
cord-309871-y17puao2	161	16	models	model	NNS
cord-309871-y17puao2	161	17	and	and	CC
cord-309871-y17puao2	161	18	In	in	IN
cord-309871-y17puao2	161	19	vitro	vitro	FW
cord-309871-y17puao2	161	20	assays	assay	NNS
cord-309871-y17puao2	161	21	for	for	IN
cord-309871-y17puao2	161	22	the	the	DT
cord-309871-y17puao2	161	23	screening	screening	NN
cord-309871-y17puao2	161	24	of	of	IN
cord-309871-y17puao2	161	25	modulators	modulator	NNS
cord-309871-y17puao2	161	26	of	of	IN
cord-309871-y17puao2	161	27	P	p	NN
cord-309871-y17puao2	161	28	-	-	HYPH
cord-309871-y17puao2	161	29	gp	gp	NN
cord-309871-y17puao2	161	30	,	,	,
cord-309871-y17puao2	161	31	MRP1	MRP1	NNP
cord-309871-y17puao2	161	32	and	and	CC
cord-309871-y17puao2	161	33	BCRP	BCRP	NNP
cord-309871-y17puao2	161	34	Subcellular	Subcellular	NNP
cord-309871-y17puao2	161	35	localization	localization	NN
cord-309871-y17puao2	161	36	and	and	CC
cord-309871-y17puao2	161	37	activity	activity	NN
cord-309871-y17puao2	161	38	of	of	IN
cord-309871-y17puao2	161	39	multidrug	multidrug	NN
cord-309871-y17puao2	161	40	resistance	resistance	NN
cord-309871-y17puao2	161	41	proteins	protein	NNS
cord-309871-y17puao2	161	42	Drugs	drug	NNS
cord-309871-y17puao2	161	43	as	as	IN
cord-309871-y17puao2	161	44	P	p	NN
cord-309871-y17puao2	161	45	-	-	HYPH
cord-309871-y17puao2	161	46	glycoprotein	glycoprotein	NN
cord-309871-y17puao2	161	47	substrates	substrate	NNS
cord-309871-y17puao2	161	48	,	,	,
cord-309871-y17puao2	161	49	inhibitors	inhibitor	NNS
cord-309871-y17puao2	161	50	,	,	,
cord-309871-y17puao2	161	51	and	and	CC
cord-309871-y17puao2	161	52	inducers	inducer	NNS
cord-309871-y17puao2	162	1	Lysosomal	Lysosomal	NNP
cord-309871-y17puao2	162	2	P	P	NNP
cord-309871-y17puao2	162	3	-	-	HYPH
cord-309871-y17puao2	162	4	gp	gp	NN
cord-309871-y17puao2	162	5	-	-	HYPH
cord-309871-y17puao2	162	6	MDR1	MDR1	NNP
cord-309871-y17puao2	162	7	confers	confer	VBZ
cord-309871-y17puao2	162	8	drug	drug	NN
cord-309871-y17puao2	162	9	resistance	resistance	NN
cord-309871-y17puao2	162	10	of	of	IN
cord-309871-y17puao2	162	11	brentuximab	brentuximab	NNP
cord-309871-y17puao2	162	12	vedotin	vedotin	NNP
cord-309871-y17puao2	162	13	and	and	CC
cord-309871-y17puao2	162	14	its	-PRON-	PRP$
cord-309871-y17puao2	162	15	cytotoxic	cytotoxic	JJ
cord-309871-y17puao2	162	16	payload	payload	NN
cord-309871-y17puao2	162	17	monomethyl	monomethyl	NN
cord-309871-y17puao2	162	18	auristatin	auristatin	NNP
cord-309871-y17puao2	162	19	E	E	NNP
cord-309871-y17puao2	162	20	in	in	IN
cord-309871-y17puao2	162	21	tumor	tumor	NN
cord-309871-y17puao2	162	22	cells	cell	NNS
cord-309871-y17puao2	163	1	Lysosomal	Lysosomal	NNP
cord-309871-y17puao2	163	2	trapping	trap	VBG
cord-309871-y17puao2	163	3	of	of	IN
cord-309871-y17puao2	163	4	a	a	DT
cord-309871-y17puao2	163	5	radiolabeled	radiolabele	VBN
cord-309871-y17puao2	163	6	substrate	substrate	NN
cord-309871-y17puao2	163	7	of	of	IN
cord-309871-y17puao2	163	8	P	p	NN
cord-309871-y17puao2	163	9	-	-	HYPH
cord-309871-y17puao2	163	10	glycoprotein	glycoprotein	NN
cord-309871-y17puao2	163	11	as	as	IN
cord-309871-y17puao2	163	12	a	a	DT
cord-309871-y17puao2	163	13	mechanism	mechanism	NN
cord-309871-y17puao2	163	14	for	for	IN
cord-309871-y17puao2	163	15	signal	signal	NN
cord-309871-y17puao2	163	16	amplification	amplification	NN
cord-309871-y17puao2	163	17	in	in	IN
cord-309871-y17puao2	163	18	PET	pet	NN
cord-309871-y17puao2	164	1	In	in	IN
cord-309871-y17puao2	164	2	vitro	vitro	FW
cord-309871-y17puao2	164	3	activity	activity	NN
cord-309871-y17puao2	164	4	and	and	CC
cord-309871-y17puao2	164	5	pharmacodynamic/	pharmacodynamic/	JJ
cord-309871-y17puao2	164	6	pharmacokinetic	pharmacokinetic	JJ
cord-309871-y17puao2	164	7	parameters	parameter	NNS
cord-309871-y17puao2	164	8	of	of	IN
cord-309871-y17puao2	164	9	clarithromycin	clarithromycin	NNS
cord-309871-y17puao2	164	10	and	and	CC
cord-309871-y17puao2	164	11	azithromycin	azithromycin	NN
cord-309871-y17puao2	164	12	:	:	:
cord-309871-y17puao2	164	13	why	why	WRB
cord-309871-y17puao2	164	14	they	-PRON-	PRP
cord-309871-y17puao2	164	15	matter	matter	VBP
cord-309871-y17puao2	164	16	in	in	IN
cord-309871-y17puao2	164	17	the	the	DT
cord-309871-y17puao2	164	18	treatment	treatment	NN
cord-309871-y17puao2	164	19	of	of	IN
cord-309871-y17puao2	164	20	respiratory	respiratory	JJ
cord-309871-y17puao2	164	21	tract	tract	NN
cord-309871-y17puao2	164	22	infections	infection	NNS
cord-309871-y17puao2	165	1	Chloroquine	Chloroquine	NNP
cord-309871-y17puao2	165	2	and	and	CC
cord-309871-y17puao2	165	3	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	165	4	are	be	VBP
cord-309871-y17puao2	165	5	associated	associate	VBN
cord-309871-y17puao2	165	6	with	with	IN
cord-309871-y17puao2	165	7	reduced	reduce	VBN
cord-309871-y17puao2	165	8	cardiovascular	cardiovascular	JJ
cord-309871-y17puao2	165	9	risk	risk	NN
cord-309871-y17puao2	165	10	:	:	:
cord-309871-y17puao2	165	11	a	a	DT
cord-309871-y17puao2	165	12	systematic	systematic	JJ
cord-309871-y17puao2	165	13	review	review	NN
cord-309871-y17puao2	165	14	and	and	CC
cord-309871-y17puao2	165	15	meta	meta	NNP
cord-309871-y17puao2	165	16	-	-	HYPH
cord-309871-y17puao2	165	17	analysis	analysis	NN
cord-309871-y17puao2	165	18	.	.	.
cord-309871-y17puao2	166	1	Drug	Drug	NNP
cord-309871-y17puao2	166	2	Des	Des	NNP
cord-309871-y17puao2	166	3	Dev	Dev	NNP
cord-309871-y17puao2	166	4	Ther	Ther	NNP
cord-309871-y17puao2	166	5	Excessive	excessive	JJ
cord-309871-y17puao2	166	6	lysosomal	lysosomal	JJ
cord-309871-y17puao2	166	7	ion	ion	NN
cord-309871-y17puao2	166	8	-	-	HYPH
cord-309871-y17puao2	166	9	trapping	trapping	NN
cord-309871-y17puao2	166	10	of	of	IN
cord-309871-y17puao2	166	11	hydroxychloroquine	hydroxychloroquine	NN
cord-309871-y17puao2	166	12	and	and	CC
cord-309871-y17puao2	166	13	azithromycin	azithromycin	NNP
cord-309871-y17puao2	166	14	Publisher	Publisher	NNP
cord-309871-y17puao2	166	15	's	's	POS
cord-309871-y17puao2	166	16	Note	Note	NNP
cord-309871-y17puao2	166	17	Springer	Springer	NNP
cord-309871-y17puao2	166	18	Nature	Nature	NNP
cord-309871-y17puao2	166	19	remains	remain	VBZ
cord-309871-y17puao2	166	20	neutral	neutral	JJ
cord-309871-y17puao2	166	21	with	with	IN
cord-309871-y17puao2	166	22	regard	regard	NN
cord-309871-y17puao2	166	23	to	to	IN
cord-309871-y17puao2	166	24	jurisdictional	jurisdictional	JJ
cord-309871-y17puao2	166	25	claims	claim	NNS
cord-309871-y17puao2	166	26	in	in	IN
cord-309871-y17puao2	166	27	published	publish	VBN
cord-309871-y17puao2	166	28	maps	map	NNS
cord-309871-y17puao2	166	29	and	and	CC
cord-309871-y17puao2	166	30	institutional	institutional	JJ
cord-309871-y17puao2	166	31	affiliations	affiliation	NNS