id	sid	tid	token	lemma	pos
cord-347986-ds5hm731	1	1	key	key	NN
cord-347986-ds5hm731	1	2	:	:	:
cord-347986-ds5hm731	1	3	cord-347986-ds5hm731	cord-347986-ds5hm731	NN
cord-347986-ds5hm731	1	4	authors	author	NNS
cord-347986-ds5hm731	1	5	:	:	:
cord-347986-ds5hm731	1	6	Lee	Lee	NNP
cord-347986-ds5hm731	1	7	,	,	,
cord-347986-ds5hm731	1	8	Paul	Paul	NNP
cord-347986-ds5hm731	1	9	J.	J.	NNP
cord-347986-ds5hm731	1	10	;	;	:
cord-347986-ds5hm731	1	11	Krilov	Krilov	NNP
cord-347986-ds5hm731	1	12	,	,	,
cord-347986-ds5hm731	1	13	Leonard	Leonard	NNP
cord-347986-ds5hm731	1	14	R.	R.	NNP
cord-347986-ds5hm731	1	15	title	title	NN
cord-347986-ds5hm731	1	16	:	:	:
cord-347986-ds5hm731	1	17	Developing	develop	VBG
cord-347986-ds5hm731	1	18	Infectious	Infectious	NNP
cord-347986-ds5hm731	1	19	Disease	Disease	NNP
cord-347986-ds5hm731	1	20	Strategies	Strategies	NNPS
cord-347986-ds5hm731	1	21	for	for	IN
cord-347986-ds5hm731	1	22	the	the	DT
cord-347986-ds5hm731	1	23	Developing	develop	VBG
cord-347986-ds5hm731	1	24	World	World	NNP
cord-347986-ds5hm731	1	25	date	date	NN
cord-347986-ds5hm731	1	26	:	:	:
cord-347986-ds5hm731	1	27	2007	2007	CD
cord-347986-ds5hm731	1	28	-	-	HYPH
cord-347986-ds5hm731	1	29	01	01	CD
cord-347986-ds5hm731	1	30	-	-	SYM
cord-347986-ds5hm731	1	31	26	26	CD
cord-347986-ds5hm731	1	32	journal	journal	NN
cord-347986-ds5hm731	1	33	:	:	:
cord-347986-ds5hm731	2	1	Annu	Annu	NNP
cord-347986-ds5hm731	2	2	Rep	Rep	NNP
cord-347986-ds5hm731	2	3	Med	Med	NNP
cord-347986-ds5hm731	2	4	Chem	Chem	NNP
cord-347986-ds5hm731	2	5	DOI	doi	NN
cord-347986-ds5hm731	2	6	:	:	:
cord-347986-ds5hm731	2	7	10.1016	10.1016	CD
cord-347986-ds5hm731	2	8	/	/	SYM
cord-347986-ds5hm731	2	9	s0065	s0065	NNP
cord-347986-ds5hm731	2	10	-	-	HYPH
cord-347986-ds5hm731	2	11	7743(06)41018	7743(06)41018	NNP
cord-347986-ds5hm731	2	12	-	-	HYPH
cord-347986-ds5hm731	2	13	6	6	CD
cord-347986-ds5hm731	3	1	sha	sha	NNP
cord-347986-ds5hm731	3	2	:	:	:
cord-347986-ds5hm731	4	1	67d9eeaea1ab99c91b13d170df131d8322052d62	67d9eeaea1ab99c91b13d170df131d8322052d62	CD
cord-347986-ds5hm731	5	1	doc_id	doc_id	CD
cord-347986-ds5hm731	6	1	:	:	:
cord-347986-ds5hm731	6	2	347986	347986	CD
cord-347986-ds5hm731	6	3	cord_uid	cord_uid	NNS
cord-347986-ds5hm731	6	4	:	:	:
cord-347986-ds5hm731	6	5	ds5hm731	ds5hm731	NNPS
cord-347986-ds5hm731	7	1	This	this	DT
cord-347986-ds5hm731	7	2	chapter	chapter	NN
cord-347986-ds5hm731	7	3	discusses	discuss	VBZ
cord-347986-ds5hm731	7	4	various	various	JJ
cord-347986-ds5hm731	7	5	drugs	drug	NNS
cord-347986-ds5hm731	7	6	for	for	IN
cord-347986-ds5hm731	7	7	human	human	JJ
cord-347986-ds5hm731	7	8	influenza	influenza	NN
cord-347986-ds5hm731	7	9	A	a	NN
cord-347986-ds5hm731	7	10	(	(	-LRB-
cord-347986-ds5hm731	7	11	H5N1	H5N1	NNP
cord-347986-ds5hm731	7	12	)	)	-RRB-
cord-347986-ds5hm731	7	13	and	and	CC
cord-347986-ds5hm731	7	14	multidrug	multidrug	NN
cord-347986-ds5hm731	7	15	-	-	HYPH
cord-347986-ds5hm731	7	16	resistant	resistant	JJ
cord-347986-ds5hm731	7	17	mycobacterium	mycobacterium	NN
cord-347986-ds5hm731	7	18	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	8	1	(	(	-LRB-
cord-347986-ds5hm731	8	2	MDR	MDR	NNP
cord-347986-ds5hm731	8	3	-	-	HYPH
cord-347986-ds5hm731	8	4	TB	TB	NNP
cord-347986-ds5hm731	8	5	)	)	-RRB-
cord-347986-ds5hm731	8	6	.	.	.
cord-347986-ds5hm731	9	1	The	the	DT
cord-347986-ds5hm731	9	2	H5N1	H5N1	NNP
cord-347986-ds5hm731	9	3	avian	avian	JJ
cord-347986-ds5hm731	9	4	influenza	influenza	NN
cord-347986-ds5hm731	9	5	does	do	VBZ
cord-347986-ds5hm731	9	6	not	not	RB
cord-347986-ds5hm731	9	7	presently	presently	RB
cord-347986-ds5hm731	9	8	meet	meet	VB
cord-347986-ds5hm731	9	9	the	the	DT
cord-347986-ds5hm731	9	10	criteria	criterion	NNS
cord-347986-ds5hm731	9	11	of	of	IN
cord-347986-ds5hm731	9	12	an	an	DT
cord-347986-ds5hm731	9	13	antigenically	antigenically	NN
cord-347986-ds5hm731	9	14	shifted	shift	VBN
cord-347986-ds5hm731	9	15	strain	strain	NN
cord-347986-ds5hm731	9	16	.	.	.
cord-347986-ds5hm731	10	1	It	-PRON-	PRP
cord-347986-ds5hm731	10	2	is	be	VBZ
cord-347986-ds5hm731	10	3	presently	presently	RB
cord-347986-ds5hm731	10	4	an	an	DT
cord-347986-ds5hm731	10	5	avian	avian	JJ
cord-347986-ds5hm731	10	6	strain	strain	NN
cord-347986-ds5hm731	10	7	that	that	WDT
cord-347986-ds5hm731	10	8	has	have	VBZ
cord-347986-ds5hm731	10	9	not	not	RB
cord-347986-ds5hm731	10	10	undergone	undergo	VBN
cord-347986-ds5hm731	10	11	reassortment	reassortment	NN
cord-347986-ds5hm731	10	12	with	with	IN
cord-347986-ds5hm731	10	13	a	a	DT
cord-347986-ds5hm731	10	14	human	human	JJ
cord-347986-ds5hm731	10	15	strain	strain	NN
cord-347986-ds5hm731	10	16	and	and	CC
cord-347986-ds5hm731	10	17	is	be	VBZ
cord-347986-ds5hm731	10	18	not	not	RB
cord-347986-ds5hm731	10	19	well	well	RB
cord-347986-ds5hm731	10	20	adapted	adapt	VBN
cord-347986-ds5hm731	10	21	to	to	IN
cord-347986-ds5hm731	10	22	humans	human	NNS
cord-347986-ds5hm731	10	23	.	.	.
cord-347986-ds5hm731	11	1	H5N1	H5N1	NNP
cord-347986-ds5hm731	11	2	isolates	isolate	NNS
cord-347986-ds5hm731	11	3	are	be	VBP
cord-347986-ds5hm731	11	4	resistant	resistant	JJ
cord-347986-ds5hm731	11	5	to	to	IN
cord-347986-ds5hm731	11	6	the	the	DT
cord-347986-ds5hm731	11	7	M2	M2	NNP
cord-347986-ds5hm731	11	8	inhibitors	inhibitor	NNS
cord-347986-ds5hm731	11	9	amantadine	amantadine	NNP
cord-347986-ds5hm731	11	10	and	and	CC
cord-347986-ds5hm731	11	11	rimantadine	rimantadine	NNP
cord-347986-ds5hm731	11	12	;	;	:
cord-347986-ds5hm731	11	13	these	these	DT
cord-347986-ds5hm731	11	14	antivirals	antiviral	NNS
cord-347986-ds5hm731	11	15	do	do	VBP
cord-347986-ds5hm731	11	16	not	not	RB
cord-347986-ds5hm731	11	17	have	have	VB
cord-347986-ds5hm731	11	18	a	a	DT
cord-347986-ds5hm731	11	19	role	role	NN
cord-347986-ds5hm731	11	20	for	for	IN
cord-347986-ds5hm731	11	21	the	the	DT
cord-347986-ds5hm731	11	22	treatment	treatment	NN
cord-347986-ds5hm731	11	23	or	or	CC
cord-347986-ds5hm731	11	24	prophylaxis	prophylaxis	NN
cord-347986-ds5hm731	11	25	against	against	IN
cord-347986-ds5hm731	11	26	the	the	DT
cord-347986-ds5hm731	11	27	strain	strain	NN
cord-347986-ds5hm731	11	28	.	.	.
cord-347986-ds5hm731	12	1	The	the	DT
cord-347986-ds5hm731	12	2	neuraminidase	neuraminidase	NN
cord-347986-ds5hm731	12	3	inhibitors	inhibitor	NNS
cord-347986-ds5hm731	12	4	,	,	,
cord-347986-ds5hm731	12	5	oseltamivir	oseltamivir	FW
cord-347986-ds5hm731	12	6	and	and	CC
cord-347986-ds5hm731	12	7	zanamivir	zanamivir	NNP
cord-347986-ds5hm731	12	8	,	,	,
cord-347986-ds5hm731	12	9	have	have	VBP
cord-347986-ds5hm731	12	10	in	in	FW
cord-347986-ds5hm731	12	11	vitro	vitro	FW
cord-347986-ds5hm731	12	12	activities	activity	NNS
cord-347986-ds5hm731	12	13	against	against	IN
cord-347986-ds5hm731	12	14	the	the	DT
cord-347986-ds5hm731	12	15	human	human	JJ
cord-347986-ds5hm731	12	16	H5N1	H5N1	NNP
cord-347986-ds5hm731	12	17	isolates	isolate	VBZ
cord-347986-ds5hm731	12	18	;	;	:
cord-347986-ds5hm731	12	19	however	however	RB
cord-347986-ds5hm731	12	20	,	,	,
cord-347986-ds5hm731	12	21	recent	recent	JJ
cord-347986-ds5hm731	12	22	data	datum	NNS
cord-347986-ds5hm731	12	23	suggest	suggest	VBP
cord-347986-ds5hm731	12	24	that	that	IN
cord-347986-ds5hm731	12	25	higher	high	JJR
cord-347986-ds5hm731	12	26	doses	dose	NNS
cord-347986-ds5hm731	12	27	for	for	IN
cord-347986-ds5hm731	12	28	longer	long	JJR
cord-347986-ds5hm731	12	29	periods	period	NNS
cord-347986-ds5hm731	12	30	may	may	MD
cord-347986-ds5hm731	12	31	be	be	VB
cord-347986-ds5hm731	12	32	required	require	VBN
cord-347986-ds5hm731	12	33	to	to	TO
cord-347986-ds5hm731	12	34	be	be	VB
cord-347986-ds5hm731	12	35	effective	effective	JJ
cord-347986-ds5hm731	12	36	.	.	.
cord-347986-ds5hm731	13	1	Oseltamivir	Oseltamivir	NNP
cord-347986-ds5hm731	13	2	is	be	VBZ
cord-347986-ds5hm731	13	3	an	an	DT
cord-347986-ds5hm731	13	4	oral	oral	JJ
cord-347986-ds5hm731	13	5	agent	agent	NN
cord-347986-ds5hm731	13	6	approved	approve	VBN
cord-347986-ds5hm731	13	7	for	for	IN
cord-347986-ds5hm731	13	8	prophylaxis	prophylaxis	NN
cord-347986-ds5hm731	13	9	and	and	CC
cord-347986-ds5hm731	13	10	the	the	DT
cord-347986-ds5hm731	13	11	treatment	treatment	NN
cord-347986-ds5hm731	13	12	of	of	IN
cord-347986-ds5hm731	13	13	influenza	influenza	NN
cord-347986-ds5hm731	13	14	infections	infection	NNS
cord-347986-ds5hm731	13	15	.	.	.
cord-347986-ds5hm731	14	1	Zanamivir	Zanamivir	NNP
cord-347986-ds5hm731	14	2	is	be	VBZ
cord-347986-ds5hm731	14	3	delivered	deliver	VBN
cord-347986-ds5hm731	14	4	topically	topically	RB
cord-347986-ds5hm731	14	5	to	to	IN
cord-347986-ds5hm731	14	6	the	the	DT
cord-347986-ds5hm731	14	7	respiratory	respiratory	JJ
cord-347986-ds5hm731	14	8	tract	tract	NN
cord-347986-ds5hm731	14	9	with	with	IN
cord-347986-ds5hm731	14	10	similar	similar	JJ
cord-347986-ds5hm731	14	11	indications	indication	NNS
cord-347986-ds5hm731	14	12	.	.	.
cord-347986-ds5hm731	15	1	The	the	DT
cord-347986-ds5hm731	15	2	drugs	drug	NNS
cord-347986-ds5hm731	15	3	discussed	discuss	VBD
cord-347986-ds5hm731	15	4	in	in	IN
cord-347986-ds5hm731	15	5	the	the	DT
cord-347986-ds5hm731	15	6	chapter	chapter	NN
cord-347986-ds5hm731	15	7	for	for	IN
cord-347986-ds5hm731	15	8	MDR	MDR	NNP
cord-347986-ds5hm731	15	9	-	-	HYPH
cord-347986-ds5hm731	15	10	TB	TB	NNP
cord-347986-ds5hm731	15	11	fall	fall	NN
cord-347986-ds5hm731	15	12	into	into	IN
cord-347986-ds5hm731	15	13	three	three	CD
cord-347986-ds5hm731	15	14	categories	category	NNS
cord-347986-ds5hm731	15	15	—	—	:
cord-347986-ds5hm731	15	16	quinolones	quinolones	NNP
cord-347986-ds5hm731	15	17	,	,	,
cord-347986-ds5hm731	15	18	nitroimidazoles	nitroimidazoles	NNP
cord-347986-ds5hm731	15	19	,	,	,
cord-347986-ds5hm731	15	20	and	and	CC
cord-347986-ds5hm731	15	21	pyrroles	pyrrole	NNS
cord-347986-ds5hm731	15	22	.	.	.
cord-347986-ds5hm731	16	1	Drugs	drug	NNS
cord-347986-ds5hm731	16	2	such	such	JJ
cord-347986-ds5hm731	16	3	as	as	IN
cord-347986-ds5hm731	16	4	moxifloxacin	moxifloxacin	NNS
cord-347986-ds5hm731	16	5	are	be	VBP
cord-347986-ds5hm731	16	6	methoxyfluoroquinolones	methoxyfluoroquinolone	NNS
cord-347986-ds5hm731	16	7	,	,	,
cord-347986-ds5hm731	16	8	which	which	WDT
cord-347986-ds5hm731	16	9	are	be	VBP
cord-347986-ds5hm731	16	10	already	already	RB
cord-347986-ds5hm731	16	11	available	available	JJ
cord-347986-ds5hm731	16	12	and	and	CC
cord-347986-ds5hm731	16	13	approved	approve	VBN
cord-347986-ds5hm731	16	14	for	for	IN
cord-347986-ds5hm731	16	15	the	the	DT
cord-347986-ds5hm731	16	16	treatment	treatment	NN
cord-347986-ds5hm731	16	17	of	of	IN
cord-347986-ds5hm731	16	18	acute	acute	JJ
cord-347986-ds5hm731	16	19	respiratory	respiratory	JJ
cord-347986-ds5hm731	16	20	infections	infection	NNS
cord-347986-ds5hm731	16	21	,	,	,
cord-347986-ds5hm731	16	22	such	such	JJ
cord-347986-ds5hm731	16	23	as	as	IN
cord-347986-ds5hm731	16	24	community	community	NN
cord-347986-ds5hm731	16	25	-	-	HYPH
cord-347986-ds5hm731	16	26	acquired	acquire	VBN
cord-347986-ds5hm731	16	27	pneumonia	pneumonia	NN
cord-347986-ds5hm731	16	28	,	,	,
cord-347986-ds5hm731	16	29	intra	intra	JJ
cord-347986-ds5hm731	16	30	-	-	JJ
cord-347986-ds5hm731	16	31	abdominal	abdominal	JJ
cord-347986-ds5hm731	16	32	infections	infection	NNS
cord-347986-ds5hm731	16	33	,	,	,
cord-347986-ds5hm731	16	34	acute	acute	JJ
cord-347986-ds5hm731	16	35	sinusitis	sinusitis	NN
cord-347986-ds5hm731	16	36	,	,	,
cord-347986-ds5hm731	16	37	and	and	CC
cord-347986-ds5hm731	16	38	skin	skin	NN
cord-347986-ds5hm731	16	39	infections	infection	NNS
cord-347986-ds5hm731	16	40	.	.	.
cord-347986-ds5hm731	17	1	Gatifloxacin	Gatifloxacin	NNP
cord-347986-ds5hm731	17	2	5	5	CD
cord-347986-ds5hm731	17	3	,	,	,
cord-347986-ds5hm731	17	4	is	be	VBZ
cord-347986-ds5hm731	17	5	another	another	DT
cord-347986-ds5hm731	17	6	methoxyfluoroquinolone	methoxyfluoroquinolone	NN
cord-347986-ds5hm731	17	7	that	that	WDT
cord-347986-ds5hm731	17	8	is	be	VBZ
cord-347986-ds5hm731	17	9	in	in	IN
cord-347986-ds5hm731	17	10	clinical	clinical	JJ
cord-347986-ds5hm731	17	11	development	development	NN
cord-347986-ds5hm731	17	12	for	for	IN
cord-347986-ds5hm731	17	13	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	17	14	treatment	treatment	NN
cord-347986-ds5hm731	17	15	.	.	.
cord-347986-ds5hm731	18	1	New	new	JJ
cord-347986-ds5hm731	18	2	infectious	infectious	JJ
cord-347986-ds5hm731	18	3	diseases	disease	NNS
cord-347986-ds5hm731	18	4	continue	continue	VBP
cord-347986-ds5hm731	18	5	to	to	TO
cord-347986-ds5hm731	18	6	emerge	emerge	VB
cord-347986-ds5hm731	18	7	and	and	CC
cord-347986-ds5hm731	18	8	old	old	JJ
cord-347986-ds5hm731	18	9	ones	one	NNS
cord-347986-ds5hm731	18	10	have	have	VBP
cord-347986-ds5hm731	18	11	re	re	VBN
cord-347986-ds5hm731	18	12	-	-	VBN
cord-347986-ds5hm731	18	13	emerged	emerge	VBN
cord-347986-ds5hm731	18	14	in	in	IN
cord-347986-ds5hm731	18	15	recent	recent	JJ
cord-347986-ds5hm731	18	16	decades	decade	NNS
cord-347986-ds5hm731	18	17	.	.	.
cord-347986-ds5hm731	19	1	Often	often	RB
cord-347986-ds5hm731	19	2	these	these	DT
cord-347986-ds5hm731	19	3	events	event	NNS
cord-347986-ds5hm731	19	4	begin	begin	VBP
cord-347986-ds5hm731	19	5	and	and	CC
cord-347986-ds5hm731	19	6	take	take	VB
cord-347986-ds5hm731	19	7	root	root	NN
cord-347986-ds5hm731	19	8	in	in	IN
cord-347986-ds5hm731	19	9	developing	develop	VBG
cord-347986-ds5hm731	19	10	countries	country	NNS
cord-347986-ds5hm731	19	11	.	.	.
cord-347986-ds5hm731	20	1	Infectious	infectious	JJ
cord-347986-ds5hm731	20	2	diseases	disease	NNS
cord-347986-ds5hm731	20	3	of	of	IN
cord-347986-ds5hm731	20	4	the	the	DT
cord-347986-ds5hm731	20	5	developing	develop	VBG
cord-347986-ds5hm731	20	6	world	world	NN
cord-347986-ds5hm731	20	7	or	or	CC
cord-347986-ds5hm731	20	8	emerging	emerge	VBG
cord-347986-ds5hm731	20	9	infections	infection	NNS
cord-347986-ds5hm731	20	10	are	be	VBP
cord-347986-ds5hm731	20	11	defined	define	VBN
cord-347986-ds5hm731	20	12	by	by	IN
cord-347986-ds5hm731	20	13	the	the	DT
cord-347986-ds5hm731	20	14	Institute	Institute	NNP
cord-347986-ds5hm731	20	15	of	of	IN
cord-347986-ds5hm731	20	16	Medicine	Medicine	NNP
cord-347986-ds5hm731	20	17	as	as	IN
cord-347986-ds5hm731	20	18	an	an	DT
cord-347986-ds5hm731	20	19	infectious	infectious	JJ
cord-347986-ds5hm731	20	20	disease	disease	NN
cord-347986-ds5hm731	20	21	that	that	WDT
cord-347986-ds5hm731	20	22	has	have	VBZ
cord-347986-ds5hm731	20	23	come	come	VBN
cord-347986-ds5hm731	20	24	to	to	IN
cord-347986-ds5hm731	20	25	medical	medical	JJ
cord-347986-ds5hm731	20	26	attention	attention	NN
cord-347986-ds5hm731	20	27	within	within	IN
cord-347986-ds5hm731	20	28	the	the	DT
cord-347986-ds5hm731	20	29	past	past	JJ
cord-347986-ds5hm731	20	30	two	two	CD
cord-347986-ds5hm731	20	31	decades	decade	NNS
cord-347986-ds5hm731	20	32	,	,	,
cord-347986-ds5hm731	20	33	or	or	CC
cord-347986-ds5hm731	20	34	for	for	IN
cord-347986-ds5hm731	20	35	which	which	WDT
cord-347986-ds5hm731	20	36	there	there	EX
cord-347986-ds5hm731	20	37	is	be	VBZ
cord-347986-ds5hm731	20	38	a	a	DT
cord-347986-ds5hm731	20	39	potential	potential	NN
cord-347986-ds5hm731	20	40	that	that	WDT
cord-347986-ds5hm731	20	41	its	-PRON-	PRP$
cord-347986-ds5hm731	20	42	prevalence	prevalence	NN
cord-347986-ds5hm731	20	43	will	will	MD
cord-347986-ds5hm731	20	44	increase	increase	VB
cord-347986-ds5hm731	20	45	in	in	IN
cord-347986-ds5hm731	20	46	the	the	DT
cord-347986-ds5hm731	20	47	near	near	JJ
cord-347986-ds5hm731	20	48	future	future	NN
cord-347986-ds5hm731	20	49	.	.	.
cord-347986-ds5hm731	21	1	Frequently	frequently	RB
cord-347986-ds5hm731	21	2	,	,	,
cord-347986-ds5hm731	21	3	these	these	DT
cord-347986-ds5hm731	21	4	diseases	disease	NNS
cord-347986-ds5hm731	21	5	exist	exist	VBP
cord-347986-ds5hm731	21	6	in	in	IN
cord-347986-ds5hm731	21	7	nature	nature	NN
cord-347986-ds5hm731	21	8	as	as	IN
cord-347986-ds5hm731	21	9	zoonoses	zoonosis	NNS
cord-347986-ds5hm731	21	10	and	and	CC
cord-347986-ds5hm731	21	11	cross	cross	VB
cord-347986-ds5hm731	21	12	over	over	RP
cord-347986-ds5hm731	21	13	to	to	IN
cord-347986-ds5hm731	21	14	humans	human	NNS
cord-347986-ds5hm731	21	15	when	when	WRB
cord-347986-ds5hm731	21	16	people	people	NNS
cord-347986-ds5hm731	21	17	come	come	VBP
cord-347986-ds5hm731	21	18	into	into	IN
cord-347986-ds5hm731	21	19	contact	contact	NN
cord-347986-ds5hm731	21	20	with	with	IN
cord-347986-ds5hm731	21	21	formerly	formerly	RB
cord-347986-ds5hm731	21	22	isolated	isolate	VBN
cord-347986-ds5hm731	21	23	animal	animal	NN
cord-347986-ds5hm731	21	24	population	population	NN
cord-347986-ds5hm731	21	25	,	,	,
cord-347986-ds5hm731	21	26	such	such	JJ
cord-347986-ds5hm731	21	27	as	as	IN
cord-347986-ds5hm731	21	28	monkeys	monkey	NNS
cord-347986-ds5hm731	21	29	in	in	IN
cord-347986-ds5hm731	21	30	a	a	DT
cord-347986-ds5hm731	21	31	rain	rain	NN
cord-347986-ds5hm731	21	32	forest	forest	NN
cord-347986-ds5hm731	21	33	that	that	WDT
cord-347986-ds5hm731	21	34	become	become	VBP
cord-347986-ds5hm731	21	35	less	less	RBR
cord-347986-ds5hm731	21	36	isolated	isolate	VBN
cord-347986-ds5hm731	21	37	with	with	IN
cord-347986-ds5hm731	21	38	deforestation	deforestation	NN
cord-347986-ds5hm731	21	39	.	.	.
cord-347986-ds5hm731	22	1	Drug	drug	NN
cord-347986-ds5hm731	22	2	resistant	resistant	JJ
cord-347986-ds5hm731	22	3	organisms	organism	NNS
cord-347986-ds5hm731	22	4	may	may	MD
cord-347986-ds5hm731	22	5	also	also	RB
cord-347986-ds5hm731	22	6	be	be	VB
cord-347986-ds5hm731	22	7	considered	consider	VBN
cord-347986-ds5hm731	22	8	as	as	IN
cord-347986-ds5hm731	22	9	emerging	emerge	VBG
cord-347986-ds5hm731	22	10	infections	infection	NNS
cord-347986-ds5hm731	22	11	since	since	IN
cord-347986-ds5hm731	22	12	they	-PRON-	PRP
cord-347986-ds5hm731	22	13	result	result	VBP
cord-347986-ds5hm731	22	14	from	from	IN
cord-347986-ds5hm731	22	15	human	human	JJ
cord-347986-ds5hm731	22	16	influence	influence	NN
cord-347986-ds5hm731	22	17	.	.	.
cord-347986-ds5hm731	23	1	Human	human	JJ
cord-347986-ds5hm731	23	2	immunodeficiency	immunodeficiency	NN
cord-347986-ds5hm731	23	3	virus	virus	NN
cord-347986-ds5hm731	23	4	(	(	-LRB-
cord-347986-ds5hm731	23	5	HIV	HIV	NNP
cord-347986-ds5hm731	23	6	)	)	-RRB-
cord-347986-ds5hm731	23	7	,	,	,
cord-347986-ds5hm731	23	8	Ebola	Ebola	NNP
cord-347986-ds5hm731	23	9	virus	virus	NN
cord-347986-ds5hm731	23	10	,	,	,
cord-347986-ds5hm731	23	11	hantavirus	hantavirus	NN
cord-347986-ds5hm731	23	12	pulmonary	pulmonary	JJ
cord-347986-ds5hm731	23	13	syndrome	syndrome	NN
cord-347986-ds5hm731	23	14	,	,	,
cord-347986-ds5hm731	23	15	monkey	monkey	NN
cord-347986-ds5hm731	23	16	pox	pox	NN
cord-347986-ds5hm731	23	17	and	and	CC
cord-347986-ds5hm731	23	18	multidrug	multidrug	NN
cord-347986-ds5hm731	23	19	-	-	HYPH
cord-347986-ds5hm731	23	20	resistant	resistant	JJ
cord-347986-ds5hm731	23	21	Mycobacterium	Mycobacterium	NNP
cord-347986-ds5hm731	23	22	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	24	1	(	(	-LRB-
cord-347986-ds5hm731	24	2	MDR	MDR	NNP
cord-347986-ds5hm731	24	3	-	-	HYPH
cord-347986-ds5hm731	24	4	TB	TB	NNP
cord-347986-ds5hm731	24	5	)	)	-RRB-
cord-347986-ds5hm731	24	6	,	,	,
cord-347986-ds5hm731	24	7	Severe	severe	JJ
cord-347986-ds5hm731	24	8	Acute	acute	JJ
cord-347986-ds5hm731	24	9	Respiratory	Respiratory	NNP
cord-347986-ds5hm731	24	10	Syndrome	Syndrome	NNP
cord-347986-ds5hm731	24	11	(	(	-LRB-
cord-347986-ds5hm731	24	12	SARS	SARS	NNP
cord-347986-ds5hm731	24	13	)	)	-RRB-
cord-347986-ds5hm731	25	1	associated	associated	JJ
cord-347986-ds5hm731	25	2	coronavirus	coronavirus	NN
cord-347986-ds5hm731	25	3	and	and	CC
cord-347986-ds5hm731	25	4	avian	avian	JJ
cord-347986-ds5hm731	25	5	influenza	influenza	NN
cord-347986-ds5hm731	25	6	are	be	VBP
cord-347986-ds5hm731	25	7	examples	example	NNS
cord-347986-ds5hm731	25	8	of	of	IN
cord-347986-ds5hm731	25	9	emerging	emerge	VBG
cord-347986-ds5hm731	25	10	infections	infection	NNS
cord-347986-ds5hm731	25	11	.	.	.
cord-347986-ds5hm731	26	1	Many	many	JJ
cord-347986-ds5hm731	26	2	of	of	IN
cord-347986-ds5hm731	26	3	these	these	DT
cord-347986-ds5hm731	26	4	infections	infection	NNS
cord-347986-ds5hm731	26	5	have	have	VBP
cord-347986-ds5hm731	26	6	arisen	arise	VBN
cord-347986-ds5hm731	26	7	and	and	CC
cord-347986-ds5hm731	26	8	become	become	VB
cord-347986-ds5hm731	26	9	major	major	JJ
cord-347986-ds5hm731	26	10	health	health	NN
cord-347986-ds5hm731	26	11	issues	issue	NNS
cord-347986-ds5hm731	26	12	in	in	IN
cord-347986-ds5hm731	26	13	the	the	DT
cord-347986-ds5hm731	26	14	developing	develop	VBG
cord-347986-ds5hm731	26	15	world	world	NN
cord-347986-ds5hm731	26	16	,	,	,
cord-347986-ds5hm731	26	17	in	in	IN
cord-347986-ds5hm731	26	18	part	part	NN
cord-347986-ds5hm731	26	19	due	due	IN
cord-347986-ds5hm731	26	20	to	to	IN
cord-347986-ds5hm731	26	21	selection	selection	NN
cord-347986-ds5hm731	26	22	factors	factor	NNS
cord-347986-ds5hm731	26	23	as	as	IN
cord-347986-ds5hm731	26	24	noted	note	VBN
cord-347986-ds5hm731	26	25	above	above	RB
cord-347986-ds5hm731	26	26	.	.	.
cord-347986-ds5hm731	27	1	Additionally	additionally	RB
cord-347986-ds5hm731	27	2	,	,	,
cord-347986-ds5hm731	27	3	inadequate	inadequate	JJ
cord-347986-ds5hm731	27	4	resource	resource	NN
cord-347986-ds5hm731	27	5	for	for	IN
cord-347986-ds5hm731	27	6	public	public	JJ
cord-347986-ds5hm731	27	7	health	health	NN
cord-347986-ds5hm731	27	8	surveillance	surveillance	NN
cord-347986-ds5hm731	27	9	and	and	CC
cord-347986-ds5hm731	27	10	treatment	treatment	NN
cord-347986-ds5hm731	27	11	of	of	IN
cord-347986-ds5hm731	27	12	these	these	DT
cord-347986-ds5hm731	27	13	illnesses	illness	NNS
cord-347986-ds5hm731	27	14	plus	plus	CC
cord-347986-ds5hm731	27	15	poor	poor	JJ
cord-347986-ds5hm731	27	16	sanitation	sanitation	NN
cord-347986-ds5hm731	27	17	and	and	CC
cord-347986-ds5hm731	27	18	nutritional	nutritional	JJ
cord-347986-ds5hm731	27	19	status	status	NN
cord-347986-ds5hm731	27	20	may	may	MD
cord-347986-ds5hm731	27	21	contribute	contribute	VB
cord-347986-ds5hm731	27	22	to	to	IN
cord-347986-ds5hm731	27	23	their	-PRON-	PRP$
cord-347986-ds5hm731	27	24	flourishing	flourishing	NN
cord-347986-ds5hm731	27	25	.	.	.
cord-347986-ds5hm731	28	1	Once	once	RB
cord-347986-ds5hm731	28	2	established	establish	VBN
cord-347986-ds5hm731	28	3	,	,	,
cord-347986-ds5hm731	28	4	these	these	DT
cord-347986-ds5hm731	28	5	illnesses	illness	NNS
cord-347986-ds5hm731	28	6	then	then	RB
cord-347986-ds5hm731	28	7	pose	pose	VBP
cord-347986-ds5hm731	28	8	concerns	concern	NNS
cord-347986-ds5hm731	28	9	for	for	IN
cord-347986-ds5hm731	28	10	all	all	DT
cord-347986-ds5hm731	28	11	mankind	mankind	NN
cord-347986-ds5hm731	28	12	as	as	IN
cord-347986-ds5hm731	28	13	we	-PRON-	PRP
cord-347986-ds5hm731	28	14	have	have	VBP
cord-347986-ds5hm731	28	15	truly	truly	RB
cord-347986-ds5hm731	28	16	become	become	VBN
cord-347986-ds5hm731	28	17	a	a	DT
cord-347986-ds5hm731	28	18	global	global	JJ
cord-347986-ds5hm731	28	19	community	community	NN
cord-347986-ds5hm731	28	20	.	.	.
cord-347986-ds5hm731	29	1	For	for	IN
cord-347986-ds5hm731	29	2	these	these	DT
cord-347986-ds5hm731	29	3	same	same	JJ
cord-347986-ds5hm731	29	4	reasons	reason	NNS
cord-347986-ds5hm731	29	5	even	even	RB
cord-347986-ds5hm731	29	6	common	common	JJ
cord-347986-ds5hm731	29	7	infections	infection	NNS
cord-347986-ds5hm731	29	8	such	such	JJ
cord-347986-ds5hm731	29	9	as	as	IN
cord-347986-ds5hm731	29	10	rotavirus	rotavirus	JJ
cord-347986-ds5hm731	29	11	gastrointestinal	gastrointestinal	JJ
cord-347986-ds5hm731	29	12	infection	infection	NN
cord-347986-ds5hm731	29	13	or	or	CC
cord-347986-ds5hm731	29	14	respiratory	respiratory	JJ
cord-347986-ds5hm731	29	15	syncytial	syncytial	JJ
cord-347986-ds5hm731	29	16	virus	virus	NN
cord-347986-ds5hm731	30	1	(	(	-LRB-
cord-347986-ds5hm731	30	2	RSV	RSV	NNP
cord-347986-ds5hm731	30	3	)	)	-RRB-
cord-347986-ds5hm731	30	4	exert	exert	VB
cord-347986-ds5hm731	30	5	a	a	DT
cord-347986-ds5hm731	30	6	greater	great	JJR
cord-347986-ds5hm731	30	7	toll	toll	NN
cord-347986-ds5hm731	30	8	in	in	IN
cord-347986-ds5hm731	30	9	the	the	DT
cord-347986-ds5hm731	30	10	developing	develop	VBG
cord-347986-ds5hm731	30	11	world	world	NN
cord-347986-ds5hm731	30	12	.	.	.
cord-347986-ds5hm731	31	1	Thus	thus	RB
cord-347986-ds5hm731	31	2	,	,	,
cord-347986-ds5hm731	31	3	even	even	RB
cord-347986-ds5hm731	31	4	as	as	IN
cord-347986-ds5hm731	31	5	molecular	molecular	JJ
cord-347986-ds5hm731	31	6	biology	biology	NN
cord-347986-ds5hm731	31	7	advances	advance	VBZ
cord-347986-ds5hm731	31	8	approaches	approach	NNS
cord-347986-ds5hm731	31	9	to	to	IN
cord-347986-ds5hm731	31	10	diagnoses	diagnosis	NNS
cord-347986-ds5hm731	31	11	,	,	,
cord-347986-ds5hm731	31	12	new	new	JJ
cord-347986-ds5hm731	31	13	challenges	challenge	NNS
cord-347986-ds5hm731	31	14	to	to	IN
cord-347986-ds5hm731	31	15	prevention	prevention	NN
cord-347986-ds5hm731	31	16	and	and	CC
cord-347986-ds5hm731	31	17	treatment	treatment	NN
cord-347986-ds5hm731	31	18	of	of	IN
cord-347986-ds5hm731	31	19	infectious	infectious	JJ
cord-347986-ds5hm731	31	20	diseases	disease	NNS
cord-347986-ds5hm731	31	21	continue	continue	VBP
cord-347986-ds5hm731	31	22	to	to	TO
cord-347986-ds5hm731	31	23	emerge	emerge	VB
cord-347986-ds5hm731	31	24	.	.	.
cord-347986-ds5hm731	32	1	Through	through	IN
cord-347986-ds5hm731	32	2	a	a	DT
cord-347986-ds5hm731	32	3	discussion	discussion	NN
cord-347986-ds5hm731	32	4	of	of	IN
cord-347986-ds5hm731	32	5	avian	avian	JJ
cord-347986-ds5hm731	32	6	influenza	influenza	NN
cord-347986-ds5hm731	32	7	and	and	CC
cord-347986-ds5hm731	32	8	MDR	MDR	NNP
cord-347986-ds5hm731	32	9	-	-	HYPH
cord-347986-ds5hm731	32	10	TB	TB	NNP
cord-347986-ds5hm731	32	11	,	,	,
cord-347986-ds5hm731	32	12	primarily	primarily	RB
cord-347986-ds5hm731	32	13	,	,	,
cord-347986-ds5hm731	32	14	we	-PRON-	PRP
cord-347986-ds5hm731	32	15	will	will	MD
cord-347986-ds5hm731	32	16	demonstrate	demonstrate	VB
cord-347986-ds5hm731	32	17	the	the	DT
cord-347986-ds5hm731	32	18	magnitude	magnitude	NN
cord-347986-ds5hm731	32	19	of	of	IN
cord-347986-ds5hm731	32	20	the	the	DT
cord-347986-ds5hm731	32	21	problems	problem	NNS
cord-347986-ds5hm731	32	22	of	of	IN
cord-347986-ds5hm731	32	23	infectious	infectious	JJ
cord-347986-ds5hm731	32	24	diseases	disease	NNS
cord-347986-ds5hm731	32	25	in	in	IN
cord-347986-ds5hm731	32	26	the	the	DT
cord-347986-ds5hm731	32	27	developing	develop	VBG
cord-347986-ds5hm731	32	28	world	world	NN
cord-347986-ds5hm731	32	29	and	and	CC
cord-347986-ds5hm731	32	30	discuss	discuss	VB
cord-347986-ds5hm731	32	31	approaches	approach	NNS
cord-347986-ds5hm731	32	32	that	that	WDT
cord-347986-ds5hm731	32	33	can	can	MD
cord-347986-ds5hm731	32	34	be	be	VB
cord-347986-ds5hm731	32	35	taken	take	VBN
cord-347986-ds5hm731	32	36	to	to	IN
cord-347986-ds5hm731	32	37	in	in	IN
cord-347986-ds5hm731	32	38	an	an	DT
cord-347986-ds5hm731	32	39	attempt	attempt	NN
cord-347986-ds5hm731	32	40	to	to	TO
cord-347986-ds5hm731	32	41	monitor	monitor	VB
cord-347986-ds5hm731	32	42	and	and	CC
cord-347986-ds5hm731	32	43	contain	contain	VB
cord-347986-ds5hm731	32	44	these	these	DT
cord-347986-ds5hm731	32	45	new	new	JJ
cord-347986-ds5hm731	32	46	threats	threat	NNS
cord-347986-ds5hm731	32	47	as	as	IN
cord-347986-ds5hm731	32	48	they	-PRON-	PRP
cord-347986-ds5hm731	32	49	emerge	emerge	VBP
cord-347986-ds5hm731	32	50	.	.	.
cord-347986-ds5hm731	33	1	Throughout	throughout	IN
cord-347986-ds5hm731	33	2	history	history	NN
cord-347986-ds5hm731	33	3	influenza	influenza	NN
cord-347986-ds5hm731	33	4	has	have	VBZ
cord-347986-ds5hm731	33	5	been	be	VBN
cord-347986-ds5hm731	33	6	a	a	DT
cord-347986-ds5hm731	33	7	major	major	JJ
cord-347986-ds5hm731	33	8	infectious	infectious	JJ
cord-347986-ds5hm731	33	9	disease	disease	NN
cord-347986-ds5hm731	33	10	problem	problem	NN
cord-347986-ds5hm731	33	11	for	for	IN
cord-347986-ds5hm731	33	12	man	man	NN
cord-347986-ds5hm731	33	13	causing	cause	VBG
cord-347986-ds5hm731	33	14	significant	significant	JJ
cord-347986-ds5hm731	33	15	morbidity	morbidity	NN
cord-347986-ds5hm731	33	16	and	and	CC
cord-347986-ds5hm731	33	17	mortality	mortality	NN
cord-347986-ds5hm731	33	18	.	.	.
cord-347986-ds5hm731	34	1	Influenza	influenza	NN
cord-347986-ds5hm731	34	2	viruses	virus	NNS
cord-347986-ds5hm731	34	3	are	be	VBP
cord-347986-ds5hm731	34	4	members	member	NNS
cord-347986-ds5hm731	34	5	of	of	IN
cord-347986-ds5hm731	34	6	the	the	DT
cord-347986-ds5hm731	34	7	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-347986-ds5hm731	34	8	(	(	-LRB-
cord-347986-ds5hm731	35	1	myxo	myxo	NNP
cord-347986-ds5hm731	35	2	¼	¼	NNP
cord-347986-ds5hm731	35	3	mucous	mucous	NN
cord-347986-ds5hm731	35	4	,	,	,
cord-347986-ds5hm731	35	5	Gr	Gr	NNP
cord-347986-ds5hm731	35	6	.	.	NNP
cord-347986-ds5hm731	35	7	)	)	-RRB-
cord-347986-ds5hm731	35	8	family	family	NN
cord-347986-ds5hm731	35	9	and	and	CC
cord-347986-ds5hm731	35	10	are	be	VBP
cord-347986-ds5hm731	35	11	classified	classify	VBN
cord-347986-ds5hm731	35	12	into	into	IN
cord-347986-ds5hm731	35	13	three	three	CD
cord-347986-ds5hm731	35	14	types	type	NNS
cord-347986-ds5hm731	35	15	A	A	NNP
cord-347986-ds5hm731	35	16	,	,	,
cord-347986-ds5hm731	35	17	B	b	NN
cord-347986-ds5hm731	35	18	,	,	,
cord-347986-ds5hm731	35	19	and	and	CC
cord-347986-ds5hm731	35	20	C	C	NNP
cord-347986-ds5hm731	35	21	,	,	,
cord-347986-ds5hm731	35	22	based	base	VBN
cord-347986-ds5hm731	35	23	on	on	IN
cord-347986-ds5hm731	35	24	the	the	DT
cord-347986-ds5hm731	35	25	composition	composition	NN
cord-347986-ds5hm731	35	26	of	of	IN
cord-347986-ds5hm731	35	27	their	-PRON-	PRP$
cord-347986-ds5hm731	35	28	viral	viral	JJ
cord-347986-ds5hm731	35	29	nuclear	nuclear	JJ
cord-347986-ds5hm731	35	30	proteins	protein	NNS
cord-347986-ds5hm731	35	31	.	.	.
cord-347986-ds5hm731	36	1	Influenza	Influenza	NNP
cord-347986-ds5hm731	36	2	A	a	DT
cord-347986-ds5hm731	36	3	viruses	virus	NNS
cord-347986-ds5hm731	36	4	are	be	VBP
cord-347986-ds5hm731	36	5	further	further	RB
cord-347986-ds5hm731	36	6	categorized	categorize	VBN
cord-347986-ds5hm731	36	7	into	into	IN
cord-347986-ds5hm731	36	8	subtypes	subtype	NNS
cord-347986-ds5hm731	36	9	based	base	VBN
cord-347986-ds5hm731	36	10	on	on	IN
cord-347986-ds5hm731	36	11	the	the	DT
cord-347986-ds5hm731	36	12	antigenic	antigenic	JJ
cord-347986-ds5hm731	36	13	structure	structure	NN
cord-347986-ds5hm731	36	14	of	of	IN
cord-347986-ds5hm731	36	15	the	the	DT
cord-347986-ds5hm731	36	16	two	two	CD
cord-347986-ds5hm731	36	17	-	-	HYPH
cord-347986-ds5hm731	36	18	surface	surface	NN
cord-347986-ds5hm731	36	19	membrane	membrane	NN
cord-347986-ds5hm731	36	20	glycoproteins	glycoprotein	NNS
cord-347986-ds5hm731	36	21	,	,	,
cord-347986-ds5hm731	36	22	hemagglutinin	hemagglutinin	NN
cord-347986-ds5hm731	36	23	(	(	-LRB-
cord-347986-ds5hm731	36	24	H	H	NNP
cord-347986-ds5hm731	36	25	)	)	-RRB-
cord-347986-ds5hm731	36	26	and	and	CC
cord-347986-ds5hm731	36	27	neuraminidase	neuraminidase	NN
cord-347986-ds5hm731	36	28	(	(	-LRB-
cord-347986-ds5hm731	36	29	N	N	NNP
cord-347986-ds5hm731	36	30	)	)	-RRB-
cord-347986-ds5hm731	36	31	.	.	.
cord-347986-ds5hm731	37	1	Both	both	DT
cord-347986-ds5hm731	37	2	of	of	IN
cord-347986-ds5hm731	37	3	these	these	DT
cord-347986-ds5hm731	37	4	proteins	protein	NNS
cord-347986-ds5hm731	37	5	play	play	VBP
cord-347986-ds5hm731	37	6	critical	critical	JJ
cord-347986-ds5hm731	37	7	roles	role	NNS
cord-347986-ds5hm731	37	8	in	in	IN
cord-347986-ds5hm731	37	9	the	the	DT
cord-347986-ds5hm731	37	10	viral	viral	JJ
cord-347986-ds5hm731	37	11	life	life	NN
cord-347986-ds5hm731	37	12	cycle	cycle	NN
cord-347986-ds5hm731	37	13	.	.	.
cord-347986-ds5hm731	38	1	The	the	DT
cord-347986-ds5hm731	38	2	hemagglutinin	hemagglutinin	NN
cord-347986-ds5hm731	38	3	protein	protein	NN
cord-347986-ds5hm731	38	4	is	be	VBZ
cord-347986-ds5hm731	38	5	involved	involve	VBN
cord-347986-ds5hm731	38	6	in	in	IN
cord-347986-ds5hm731	38	7	the	the	DT
cord-347986-ds5hm731	38	8	process	process	NN
cord-347986-ds5hm731	38	9	of	of	IN
cord-347986-ds5hm731	38	10	viral	viral	JJ
cord-347986-ds5hm731	38	11	attachment	attachment	NN
cord-347986-ds5hm731	38	12	and	and	CC
cord-347986-ds5hm731	38	13	entry	entry	NN
cord-347986-ds5hm731	38	14	to	to	IN
cord-347986-ds5hm731	38	15	the	the	DT
cord-347986-ds5hm731	38	16	host	host	NN
cord-347986-ds5hm731	38	17	epithelial	epithelial	JJ
cord-347986-ds5hm731	38	18	cell	cell	NN
cord-347986-ds5hm731	38	19	to	to	TO
cord-347986-ds5hm731	38	20	initiate	initiate	VB
cord-347986-ds5hm731	38	21	the	the	DT
cord-347986-ds5hm731	38	22	process	process	NN
cord-347986-ds5hm731	38	23	of	of	IN
cord-347986-ds5hm731	38	24	viral	viral	JJ
cord-347986-ds5hm731	38	25	infection	infection	NN
cord-347986-ds5hm731	38	26	.	.	.
cord-347986-ds5hm731	39	1	The	the	DT
cord-347986-ds5hm731	39	2	neuraminidase	neuraminidase	NN
cord-347986-ds5hm731	39	3	is	be	VBZ
cord-347986-ds5hm731	39	4	involved	involve	VBN
cord-347986-ds5hm731	39	5	at	at	IN
cord-347986-ds5hm731	39	6	the	the	DT
cord-347986-ds5hm731	39	7	other	other	JJ
cord-347986-ds5hm731	39	8	end	end	NN
cord-347986-ds5hm731	39	9	of	of	IN
cord-347986-ds5hm731	39	10	the	the	DT
cord-347986-ds5hm731	39	11	replication	replication	NN
cord-347986-ds5hm731	39	12	cycle	cycle	NN
cord-347986-ds5hm731	39	13	as	as	IN
cord-347986-ds5hm731	39	14	it	-PRON-	PRP
cord-347986-ds5hm731	39	15	functions	function	VBZ
cord-347986-ds5hm731	39	16	to	to	TO
cord-347986-ds5hm731	39	17	snip	snip	VB
cord-347986-ds5hm731	39	18	the	the	DT
cord-347986-ds5hm731	39	19	cell	cell	NN
cord-347986-ds5hm731	39	20	membrane	membrane	NN
cord-347986-ds5hm731	39	21	releasing	release	VBG
cord-347986-ds5hm731	39	22	newly	newly	RB
cord-347986-ds5hm731	39	23	made	make	VBN
cord-347986-ds5hm731	39	24	viral	viral	JJ
cord-347986-ds5hm731	39	25	particles	particle	NNS
cord-347986-ds5hm731	39	26	from	from	IN
cord-347986-ds5hm731	39	27	the	the	DT
cord-347986-ds5hm731	39	28	infected	infected	JJ
cord-347986-ds5hm731	39	29	cell	cell	NN
cord-347986-ds5hm731	39	30	.	.	.
cord-347986-ds5hm731	40	1	There	there	EX
cord-347986-ds5hm731	40	2	are	be	VBP
cord-347986-ds5hm731	40	3	15	15	CD
cord-347986-ds5hm731	40	4	distinct	distinct	JJ
cord-347986-ds5hm731	40	5	hemagglutinins	hemagglutinin	NNS
cord-347986-ds5hm731	40	6	(	(	-LRB-
cord-347986-ds5hm731	40	7	H1-H15	H1-H15	NNP
cord-347986-ds5hm731	40	8	)	)	-RRB-
cord-347986-ds5hm731	40	9	and	and	CC
cord-347986-ds5hm731	40	10	nine	nine	CD
cord-347986-ds5hm731	40	11	neuraminidase	neuraminidase	NN
cord-347986-ds5hm731	40	12	subtypes	subtype	NNS
cord-347986-ds5hm731	40	13	(	(	-LRB-
cord-347986-ds5hm731	40	14	N1-N9	N1-N9	NNP
cord-347986-ds5hm731	40	15	)	)	-RRB-
cord-347986-ds5hm731	40	16	that	that	WDT
cord-347986-ds5hm731	40	17	have	have	VBP
cord-347986-ds5hm731	40	18	been	be	VBN
cord-347986-ds5hm731	40	19	described	describe	VBN
cord-347986-ds5hm731	40	20	in	in	IN
cord-347986-ds5hm731	40	21	nature	nature	NN
cord-347986-ds5hm731	40	22	.	.	.
cord-347986-ds5hm731	41	1	Until	until	IN
cord-347986-ds5hm731	41	2	recently	recently	RB
cord-347986-ds5hm731	41	3	,	,	,
cord-347986-ds5hm731	41	4	human	human	JJ
cord-347986-ds5hm731	41	5	influenza	influenza	NN
cord-347986-ds5hm731	41	6	viruses	virus	NNS
cord-347986-ds5hm731	41	7	only	only	RB
cord-347986-ds5hm731	41	8	contained	contain	VBD
cord-347986-ds5hm731	41	9	H1	h1	NN
cord-347986-ds5hm731	41	10	,	,	,
cord-347986-ds5hm731	41	11	H2	H2	NNP
cord-347986-ds5hm731	41	12	,	,	,
cord-347986-ds5hm731	41	13	H3	H3	NNP
cord-347986-ds5hm731	41	14	and	and	CC
cord-347986-ds5hm731	41	15	N1	N1	NNP
cord-347986-ds5hm731	41	16	or	or	CC
cord-347986-ds5hm731	41	17	N2	N2	NNP
cord-347986-ds5hm731	41	18	subtypes	subtype	NNS
cord-347986-ds5hm731	41	19	.	.	.
cord-347986-ds5hm731	42	1	Avian	avian	JJ
cord-347986-ds5hm731	42	2	influenza	influenza	NN
cord-347986-ds5hm731	42	3	viruses	virus	NNS
cord-347986-ds5hm731	42	4	may	may	MD
cord-347986-ds5hm731	42	5	have	have	VB
cord-347986-ds5hm731	42	6	additional	additional	JJ
cord-347986-ds5hm731	42	7	combinations	combination	NNS
cord-347986-ds5hm731	42	8	of	of	IN
cord-347986-ds5hm731	42	9	the	the	DT
cord-347986-ds5hm731	42	10	15	15	CD
cord-347986-ds5hm731	42	11	hemagglutinin	hemagglutinin	NNS
cord-347986-ds5hm731	42	12	and	and	CC
cord-347986-ds5hm731	42	13	9	9	CD
cord-347986-ds5hm731	42	14	neuraminidase	neuraminidase	NN
cord-347986-ds5hm731	42	15	proteins	protein	NNS
cord-347986-ds5hm731	42	16	.	.	.
cord-347986-ds5hm731	43	1	The	the	DT
cord-347986-ds5hm731	43	2	influenza	influenza	NN
cord-347986-ds5hm731	43	3	virus	virus	NN
cord-347986-ds5hm731	43	4	genome	genome	NN
cord-347986-ds5hm731	43	5	is	be	VBZ
cord-347986-ds5hm731	43	6	composed	compose	VBN
cord-347986-ds5hm731	43	7	of	of	IN
cord-347986-ds5hm731	43	8	8	8	CD
cord-347986-ds5hm731	43	9	segmented	segmented	JJ
cord-347986-ds5hm731	43	10	pieces	piece	NNS
cord-347986-ds5hm731	43	11	of	of	IN
cord-347986-ds5hm731	43	12	RNA	RNA	NNP
cord-347986-ds5hm731	43	13	with	with	IN
cord-347986-ds5hm731	43	14	each	each	DT
cord-347986-ds5hm731	43	15	coding	code	VBG
cord-347986-ds5hm731	43	16	for	for	IN
cord-347986-ds5hm731	43	17	a	a	DT
cord-347986-ds5hm731	43	18	separate	separate	JJ
cord-347986-ds5hm731	43	19	viral	viral	JJ
cord-347986-ds5hm731	43	20	protein	protein	NN
cord-347986-ds5hm731	43	21	.	.	.
cord-347986-ds5hm731	44	1	These	these	DT
cord-347986-ds5hm731	44	2	viral	viral	JJ
cord-347986-ds5hm731	44	3	proteins	protein	NNS
cord-347986-ds5hm731	44	4	may	may	MD
cord-347986-ds5hm731	44	5	change	change	VB
cord-347986-ds5hm731	44	6	slowly	slowly	RB
cord-347986-ds5hm731	44	7	(	(	-LRB-
cord-347986-ds5hm731	44	8	antigenic	antigenic	JJ
cord-347986-ds5hm731	44	9	drift	drift	NN
cord-347986-ds5hm731	44	10	)	)	-RRB-
cord-347986-ds5hm731	44	11	through	through	IN
cord-347986-ds5hm731	44	12	point	point	NN
cord-347986-ds5hm731	44	13	mutations	mutation	NNS
cord-347986-ds5hm731	44	14	occurring	occur	VBG
cord-347986-ds5hm731	44	15	during	during	IN
cord-347986-ds5hm731	44	16	viral	viral	JJ
cord-347986-ds5hm731	44	17	replication	replication	NN
cord-347986-ds5hm731	44	18	or	or	CC
cord-347986-ds5hm731	44	19	suddenly	suddenly	RB
cord-347986-ds5hm731	44	20	(	(	-LRB-
cord-347986-ds5hm731	44	21	antigenic	antigenic	JJ
cord-347986-ds5hm731	44	22	shift	shift	NN
cord-347986-ds5hm731	44	23	)	)	-RRB-
cord-347986-ds5hm731	44	24	.	.	.
cord-347986-ds5hm731	45	1	The	the	DT
cord-347986-ds5hm731	45	2	latter	latter	JJ
cord-347986-ds5hm731	45	3	occurs	occur	VBZ
cord-347986-ds5hm731	45	4	only	only	RB
cord-347986-ds5hm731	45	5	in	in	IN
cord-347986-ds5hm731	45	6	influenza	influenza	NN
cord-347986-ds5hm731	45	7	A	a	DT
cord-347986-ds5hm731	45	8	strains	strain	NNS
cord-347986-ds5hm731	45	9	and	and	CC
cord-347986-ds5hm731	45	10	it	-PRON-	PRP
cord-347986-ds5hm731	45	11	results	result	VBZ
cord-347986-ds5hm731	45	12	from	from	IN
cord-347986-ds5hm731	45	13	a	a	DT
cord-347986-ds5hm731	45	14	combination	combination	NN
cord-347986-ds5hm731	45	15	of	of	IN
cord-347986-ds5hm731	45	16	the	the	DT
cord-347986-ds5hm731	45	17	segmented	segmented	JJ
cord-347986-ds5hm731	45	18	genome	genome	NN
cord-347986-ds5hm731	45	19	described	describe	VBN
cord-347986-ds5hm731	45	20	above	above	RB
cord-347986-ds5hm731	45	21	and	and	CC
cord-347986-ds5hm731	45	22	the	the	DT
cord-347986-ds5hm731	45	23	ability	ability	NN
cord-347986-ds5hm731	45	24	of	of	IN
cord-347986-ds5hm731	45	25	influenza	influenza	NN
cord-347986-ds5hm731	45	26	A	a	DT
cord-347986-ds5hm731	45	27	strains	strain	NNS
cord-347986-ds5hm731	45	28	of	of	IN
cord-347986-ds5hm731	45	29	human	human	JJ
cord-347986-ds5hm731	45	30	and	and	CC
cord-347986-ds5hm731	45	31	avian	avian	JJ
cord-347986-ds5hm731	45	32	origin	origin	NN
cord-347986-ds5hm731	45	33	to	to	TO
cord-347986-ds5hm731	45	34	co	co	VB
cord-347986-ds5hm731	45	35	-	-	VB
cord-347986-ds5hm731	45	36	infect	infect	VB
cord-347986-ds5hm731	45	37	the	the	DT
cord-347986-ds5hm731	45	38	same	same	JJ
cord-347986-ds5hm731	45	39	host	host	NN
cord-347986-ds5hm731	45	40	(	(	-LRB-
cord-347986-ds5hm731	45	41	typically	typically	RB
cord-347986-ds5hm731	45	42	,	,	,
cord-347986-ds5hm731	45	43	pigs	pig	NNS
cord-347986-ds5hm731	45	44	or	or	CC
cord-347986-ds5hm731	45	45	swines	swine	NNS
cord-347986-ds5hm731	45	46	are	be	VBP
cord-347986-ds5hm731	45	47	most	most	RBS
cord-347986-ds5hm731	45	48	receptive	receptive	JJ
cord-347986-ds5hm731	45	49	)	)	-RRB-
cord-347986-ds5hm731	45	50	,	,	,
cord-347986-ds5hm731	45	51	and	and	CC
cord-347986-ds5hm731	45	52	share	share	VB
cord-347986-ds5hm731	45	53	their	-PRON-	PRP$
cord-347986-ds5hm731	45	54	genetic	genetic	JJ
cord-347986-ds5hm731	45	55	information	information	NN
cord-347986-ds5hm731	45	56	.	.	.
cord-347986-ds5hm731	46	1	During	during	IN
cord-347986-ds5hm731	46	2	this	this	DT
cord-347986-ds5hm731	46	3	process	process	NN
cord-347986-ds5hm731	46	4	of	of	IN
cord-347986-ds5hm731	46	5	reassortment	reassortment	NN
cord-347986-ds5hm731	46	6	a	a	DT
cord-347986-ds5hm731	46	7	new	new	JJ
cord-347986-ds5hm731	46	8	strain	strain	NN
cord-347986-ds5hm731	46	9	acquiring	acquire	VBG
cord-347986-ds5hm731	46	10	one	one	CD
cord-347986-ds5hm731	46	11	of	of	IN
cord-347986-ds5hm731	46	12	the	the	DT
cord-347986-ds5hm731	46	13	avian	avian	JJ
cord-347986-ds5hm731	46	14	surface	surface	NN
cord-347986-ds5hm731	46	15	protein	protein	NN
cord-347986-ds5hm731	46	16	genes	gene	NNS
cord-347986-ds5hm731	46	17	(	(	-LRB-
cord-347986-ds5hm731	46	18	H	H	NNP
cord-347986-ds5hm731	46	19	or	or	CC
cord-347986-ds5hm731	46	20	N	N	NNP
cord-347986-ds5hm731	46	21	)	)	-RRB-
cord-347986-ds5hm731	46	22	may	may	MD
cord-347986-ds5hm731	46	23	emerge	emerge	VB
cord-347986-ds5hm731	46	24	.	.	.
cord-347986-ds5hm731	47	1	Such	such	PDT
cord-347986-ds5hm731	47	2	a	a	DT
cord-347986-ds5hm731	47	3	novel	novel	JJ
cord-347986-ds5hm731	47	4	strain	strain	NN
cord-347986-ds5hm731	47	5	then	then	RB
cord-347986-ds5hm731	47	6	eludes	elude	VBZ
cord-347986-ds5hm731	47	7	pre	pre	JJ
cord-347986-ds5hm731	47	8	-	-	JJ
cord-347986-ds5hm731	47	9	existing	existing	JJ
cord-347986-ds5hm731	47	10	immunity	immunity	NN
cord-347986-ds5hm731	47	11	in	in	IN
cord-347986-ds5hm731	47	12	people	people	NNS
cord-347986-ds5hm731	47	13	previously	previously	RB
cord-347986-ds5hm731	47	14	infected	infect	VBN
cord-347986-ds5hm731	47	15	with	with	IN
cord-347986-ds5hm731	47	16	influenza	influenza	NN
cord-347986-ds5hm731	47	17	and	and	CC
cord-347986-ds5hm731	47	18	may	may	MD
cord-347986-ds5hm731	47	19	spread	spread	VB
cord-347986-ds5hm731	47	20	rapidly	rapidly	RB
cord-347986-ds5hm731	47	21	among	among	IN
cord-347986-ds5hm731	47	22	the	the	DT
cord-347986-ds5hm731	47	23	entire	entire	JJ
cord-347986-ds5hm731	47	24	population	population	NN
cord-347986-ds5hm731	47	25	.	.	.
cord-347986-ds5hm731	48	1	This	this	DT
cord-347986-ds5hm731	48	2	defines	define	VBZ
cord-347986-ds5hm731	48	3	the	the	DT
cord-347986-ds5hm731	48	4	potential	potential	NN
cord-347986-ds5hm731	48	5	for	for	IN
cord-347986-ds5hm731	48	6	worldwide	worldwide	JJ
cord-347986-ds5hm731	48	7	spread	spread	NN
cord-347986-ds5hm731	48	8	or	or	CC
cord-347986-ds5hm731	48	9	an	an	DT
cord-347986-ds5hm731	48	10	influenza	influenza	NN
cord-347986-ds5hm731	48	11	pandemic	pandemic	NN
cord-347986-ds5hm731	48	12	.	.	.
cord-347986-ds5hm731	49	1	A	a	DT
cord-347986-ds5hm731	49	2	number	number	NN
cord-347986-ds5hm731	49	3	of	of	IN
cord-347986-ds5hm731	49	4	influenza	influenza	NN
cord-347986-ds5hm731	49	5	pandemics	pandemic	NNS
cord-347986-ds5hm731	49	6	were	be	VBD
cord-347986-ds5hm731	49	7	documented	document	VBN
cord-347986-ds5hm731	49	8	over	over	IN
cord-347986-ds5hm731	49	9	the	the	DT
cord-347986-ds5hm731	49	10	20th	20th	JJ
cord-347986-ds5hm731	49	11	century	century	NN
cord-347986-ds5hm731	49	12	with	with	IN
cord-347986-ds5hm731	49	13	the	the	DT
cord-347986-ds5hm731	49	14	most	most	RBS
cord-347986-ds5hm731	49	15	notable	notable	JJ
cord-347986-ds5hm731	49	16	being	be	VBG
cord-347986-ds5hm731	49	17	the	the	DT
cord-347986-ds5hm731	49	18	1918	1918	CD
cord-347986-ds5hm731	49	19	-	-	SYM
cord-347986-ds5hm731	49	20	1919	1919	CD
cord-347986-ds5hm731	49	21	Spanish	spanish	JJ
cord-347986-ds5hm731	49	22	or	or	CC
cord-347986-ds5hm731	49	23	swine	swine	NN
cord-347986-ds5hm731	49	24	flu	flu	NN
cord-347986-ds5hm731	49	25	epidemic	epidemic	NN
cord-347986-ds5hm731	49	26	.	.	.
cord-347986-ds5hm731	50	1	During	during	IN
cord-347986-ds5hm731	50	2	this	this	DT
cord-347986-ds5hm731	50	3	pandemic	pandemic	NN
cord-347986-ds5hm731	50	4	,	,	,
cord-347986-ds5hm731	50	5	a	a	DT
cord-347986-ds5hm731	50	6	new	new	JJ
cord-347986-ds5hm731	50	7	for	for	IN
cord-347986-ds5hm731	50	8	the	the	DT
cord-347986-ds5hm731	50	9	time	time	NN
cord-347986-ds5hm731	50	10	H1NI	h1ni	CD
cord-347986-ds5hm731	50	11	strain	strain	NN
cord-347986-ds5hm731	50	12	arose	arise	VBD
cord-347986-ds5hm731	50	13	leading	lead	VBG
cord-347986-ds5hm731	50	14	to	to	IN
cord-347986-ds5hm731	50	15	an	an	DT
cord-347986-ds5hm731	50	16	estimated	estimate	VBN
cord-347986-ds5hm731	50	17	20	20	CD
cord-347986-ds5hm731	50	18	million	million	CD
cord-347986-ds5hm731	50	19	deaths	death	NNS
cord-347986-ds5hm731	50	20	worldwide	worldwide	RB
cord-347986-ds5hm731	50	21	.	.	.
cord-347986-ds5hm731	51	1	Scientists	scientist	NNS
cord-347986-ds5hm731	51	2	to	to	IN
cord-347986-ds5hm731	51	3	this	this	DT
cord-347986-ds5hm731	51	4	date	date	NN
cord-347986-ds5hm731	51	5	,	,	,
cord-347986-ds5hm731	51	6	continue	continue	VBP
cord-347986-ds5hm731	51	7	to	to	TO
cord-347986-ds5hm731	51	8	study	study	VB
cord-347986-ds5hm731	51	9	this	this	DT
cord-347986-ds5hm731	51	10	strain	strain	NN
cord-347986-ds5hm731	51	11	attempting	attempt	VBG
cord-347986-ds5hm731	51	12	to	to	TO
cord-347986-ds5hm731	51	13	discern	discern	VB
cord-347986-ds5hm731	51	14	virulence	virulence	NN
cord-347986-ds5hm731	51	15	factors	factor	NNS
cord-347986-ds5hm731	51	16	that	that	WDT
cord-347986-ds5hm731	51	17	contributed	contribute	VBD
cord-347986-ds5hm731	51	18	to	to	IN
cord-347986-ds5hm731	51	19	the	the	DT
cord-347986-ds5hm731	51	20	severity	severity	NN
cord-347986-ds5hm731	51	21	of	of	IN
cord-347986-ds5hm731	51	22	illness	illness	NN
cord-347986-ds5hm731	51	23	caused	cause	VBN
cord-347986-ds5hm731	51	24	by	by	IN
cord-347986-ds5hm731	51	25	this	this	DT
cord-347986-ds5hm731	51	26	strain	strain	NN
cord-347986-ds5hm731	51	27	.	.	.
cord-347986-ds5hm731	52	1	It	-PRON-	PRP
cord-347986-ds5hm731	52	2	has	have	VBZ
cord-347986-ds5hm731	52	3	been	be	VBN
cord-347986-ds5hm731	52	4	suggested	suggest	VBN
cord-347986-ds5hm731	52	5	that	that	IN
cord-347986-ds5hm731	52	6	the	the	DT
cord-347986-ds5hm731	52	7	recently	recently	RB
cord-347986-ds5hm731	52	8	observed	observe	VBN
cord-347986-ds5hm731	52	9	avian	avian	JJ
cord-347986-ds5hm731	52	10	influenza	influenza	NN
cord-347986-ds5hm731	52	11	H5N1	H5N1	NNP
cord-347986-ds5hm731	52	12	strain	strain	NN
cord-347986-ds5hm731	52	13	to	to	TO
cord-347986-ds5hm731	52	14	be	be	VB
cord-347986-ds5hm731	52	15	described	describe	VBN
cord-347986-ds5hm731	52	16	below	below	IN
cord-347986-ds5hm731	52	17	may	may	MD
cord-347986-ds5hm731	52	18	share	share	VB
cord-347986-ds5hm731	52	19	some	some	DT
cord-347986-ds5hm731	52	20	of	of	IN
cord-347986-ds5hm731	52	21	these	these	DT
cord-347986-ds5hm731	52	22	same	same	JJ
cord-347986-ds5hm731	52	23	virulence	virulence	NN
cord-347986-ds5hm731	52	24	properties	property	NNS
cord-347986-ds5hm731	52	25	which	which	WDT
cord-347986-ds5hm731	52	26	may	may	MD
cord-347986-ds5hm731	52	27	contribute	contribute	VB
cord-347986-ds5hm731	52	28	to	to	IN
cord-347986-ds5hm731	52	29	the	the	DT
cord-347986-ds5hm731	52	30	450	450	CD
cord-347986-ds5hm731	52	31	%	%	NN
cord-347986-ds5hm731	52	32	mortality	mortality	NN
cord-347986-ds5hm731	52	33	observed	observe	VBN
cord-347986-ds5hm731	52	34	in	in	IN
cord-347986-ds5hm731	52	35	the	the	DT
cord-347986-ds5hm731	52	36	limited	limited	JJ
cord-347986-ds5hm731	52	37	number	number	NN
cord-347986-ds5hm731	52	38	of	of	IN
cord-347986-ds5hm731	52	39	human	human	JJ
cord-347986-ds5hm731	52	40	cases	case	NNS
cord-347986-ds5hm731	52	41	reported	report	VBN
cord-347986-ds5hm731	52	42	to	to	IN
cord-347986-ds5hm731	52	43	date	date	NN
cord-347986-ds5hm731	52	44	[	[	-LRB-
cord-347986-ds5hm731	52	45	1	1	CD
cord-347986-ds5hm731	52	46	]	]	-RRB-
cord-347986-ds5hm731	52	47	.	.	.
cord-347986-ds5hm731	53	1	Specifically	specifically	RB
cord-347986-ds5hm731	53	2	,	,	,
cord-347986-ds5hm731	53	3	this	this	DT
cord-347986-ds5hm731	53	4	virus	virus	NN
cord-347986-ds5hm731	53	5	predominately	predominately	RB
cord-347986-ds5hm731	53	6	attaches	attach	VBZ
cord-347986-ds5hm731	53	7	to	to	TO
cord-347986-ds5hm731	53	8	lower	lower	VB
cord-347986-ds5hm731	53	9	respiratory	respiratory	JJ
cord-347986-ds5hm731	53	10	tract	tract	NN
cord-347986-ds5hm731	53	11	cells	cell	NNS
cord-347986-ds5hm731	53	12	(	(	-LRB-
cord-347986-ds5hm731	53	13	type	type	NN
cord-347986-ds5hm731	53	14	II	II	NNP
cord-347986-ds5hm731	53	15	pneumocytes	pneumocyte	NNS
cord-347986-ds5hm731	53	16	,	,	,
cord-347986-ds5hm731	53	17	alveolar	alveolar	NN
cord-347986-ds5hm731	53	18	macrophages	macrophage	NNS
cord-347986-ds5hm731	53	19	and	and	CC
cord-347986-ds5hm731	53	20	nonciliated	nonciliate	VBD
cord-347986-ds5hm731	53	21	bronchiolar	bronchiolar	NNP
cord-347986-ds5hm731	53	22	cells	cell	NNS
cord-347986-ds5hm731	53	23	)	)	-RRB-
cord-347986-ds5hm731	53	24	leading	lead	VBG
cord-347986-ds5hm731	53	25	to	to	IN
cord-347986-ds5hm731	53	26	severe	severe	JJ
cord-347986-ds5hm731	53	27	lower	low	JJR
cord-347986-ds5hm731	53	28	respiratory	respiratory	JJ
cord-347986-ds5hm731	53	29	tract	tract	NN
cord-347986-ds5hm731	53	30	damage	damage	NN
cord-347986-ds5hm731	53	31	.	.	.
cord-347986-ds5hm731	54	1	However	however	RB
cord-347986-ds5hm731	54	2	,	,	,
cord-347986-ds5hm731	54	3	it	-PRON-	PRP
cord-347986-ds5hm731	54	4	does	do	VBZ
cord-347986-ds5hm731	54	5	not	not	RB
cord-347986-ds5hm731	54	6	appear	appear	VB
cord-347986-ds5hm731	54	7	to	to	TO
cord-347986-ds5hm731	54	8	attach	attach	VB
cord-347986-ds5hm731	54	9	well	well	RB
cord-347986-ds5hm731	54	10	to	to	IN
cord-347986-ds5hm731	54	11	upper	upper	JJ
cord-347986-ds5hm731	54	12	respiratory	respiratory	JJ
cord-347986-ds5hm731	54	13	tract	tract	NN
cord-347986-ds5hm731	54	14	cells	cell	NNS
cord-347986-ds5hm731	54	15	,	,	,
cord-347986-ds5hm731	54	16	possibly	possibly	RB
cord-347986-ds5hm731	54	17	explaining	explain	VBG
cord-347986-ds5hm731	54	18	the	the	DT
cord-347986-ds5hm731	54	19	low	low	JJ
cord-347986-ds5hm731	54	20	human	human	NN
cord-347986-ds5hm731	54	21	-	-	HYPH
cord-347986-ds5hm731	54	22	to	to	IN
cord-347986-ds5hm731	54	23	-	-	HYPH
cord-347986-ds5hm731	54	24	human	human	JJ
cord-347986-ds5hm731	54	25	risk	risk	NN
cord-347986-ds5hm731	54	26	from	from	IN
cord-347986-ds5hm731	54	27	this	this	DT
cord-347986-ds5hm731	54	28	strain	strain	NN
cord-347986-ds5hm731	54	29	[	[	-LRB-
cord-347986-ds5hm731	54	30	2	2	CD
cord-347986-ds5hm731	54	31	]	]	-RRB-
cord-347986-ds5hm731	54	32	.	.	.
cord-347986-ds5hm731	55	1	The	the	DT
cord-347986-ds5hm731	55	2	crowding	crowding	NN
cord-347986-ds5hm731	55	3	of	of	IN
cord-347986-ds5hm731	55	4	people	people	NNS
cord-347986-ds5hm731	55	5	,	,	,
cord-347986-ds5hm731	55	6	swine	swine	NN
cord-347986-ds5hm731	55	7	,	,	,
cord-347986-ds5hm731	55	8	and	and	CC
cord-347986-ds5hm731	55	9	bird	bird	NN
cord-347986-ds5hm731	55	10	species	specie	NNS
cord-347986-ds5hm731	55	11	in	in	IN
cord-347986-ds5hm731	55	12	areas	area	NNS
cord-347986-ds5hm731	55	13	of	of	IN
cord-347986-ds5hm731	55	14	the	the	DT
cord-347986-ds5hm731	55	15	developing	develop	VBG
cord-347986-ds5hm731	55	16	world	world	NN
cord-347986-ds5hm731	55	17	such	such	JJ
cord-347986-ds5hm731	55	18	as	as	IN
cord-347986-ds5hm731	55	19	Southeast	Southeast	NNP
cord-347986-ds5hm731	55	20	Asia	Asia	NNP
cord-347986-ds5hm731	55	21	creates	create	VBZ
cord-347986-ds5hm731	55	22	an	an	DT
cord-347986-ds5hm731	55	23	environment	environment	NN
cord-347986-ds5hm731	55	24	that	that	WDT
cord-347986-ds5hm731	55	25	favors	favor	VBZ
cord-347986-ds5hm731	55	26	the	the	DT
cord-347986-ds5hm731	55	27	origin	origin	NN
cord-347986-ds5hm731	55	28	of	of	IN
cord-347986-ds5hm731	55	29	such	such	JJ
cord-347986-ds5hm731	55	30	strains	strain	NNS
cord-347986-ds5hm731	55	31	.	.	.
cord-347986-ds5hm731	56	1	Public	public	JJ
cord-347986-ds5hm731	56	2	health	health	NN
cord-347986-ds5hm731	56	3	vigilance	vigilance	NN
cord-347986-ds5hm731	56	4	has	have	VBZ
cord-347986-ds5hm731	56	5	contributed	contribute	VBN
cord-347986-ds5hm731	56	6	to	to	TO
cord-347986-ds5hm731	56	7	prompt	prompt	VB
cord-347986-ds5hm731	56	8	recognition	recognition	NN
cord-347986-ds5hm731	56	9	of	of	IN
cord-347986-ds5hm731	56	10	new	new	JJ
cord-347986-ds5hm731	56	11	strains	strain	NNS
cord-347986-ds5hm731	56	12	as	as	IN
cord-347986-ds5hm731	56	13	they	-PRON-	PRP
cord-347986-ds5hm731	56	14	emerge	emerge	VBP
cord-347986-ds5hm731	56	15	and	and	CC
cord-347986-ds5hm731	56	16	has	have	VBZ
cord-347986-ds5hm731	56	17	contributed	contribute	VBN
cord-347986-ds5hm731	56	18	to	to	TO
cord-347986-ds5hm731	56	19	control	control	VB
cord-347986-ds5hm731	56	20	of	of	IN
cord-347986-ds5hm731	56	21	their	-PRON-	PRP$
cord-347986-ds5hm731	56	22	spread	spread	NN
cord-347986-ds5hm731	56	23	through	through	IN
cord-347986-ds5hm731	56	24	destruction	destruction	NN
cord-347986-ds5hm731	56	25	of	of	IN
cord-347986-ds5hm731	56	26	bird	bird	NN
cord-347986-ds5hm731	56	27	and/or	and/or	CC
cord-347986-ds5hm731	56	28	swine	swine	NN
cord-347986-ds5hm731	56	29	populations	population	NNS
cord-347986-ds5hm731	56	30	.	.	.
cord-347986-ds5hm731	57	1	The	the	DT
cord-347986-ds5hm731	57	2	H5N1	H5N1	NNP
cord-347986-ds5hm731	57	3	avian	avian	JJ
cord-347986-ds5hm731	57	4	influenza	influenza	NN
cord-347986-ds5hm731	57	5	that	that	WDT
cord-347986-ds5hm731	57	6	has	have	VBZ
cord-347986-ds5hm731	57	7	attracted	attract	VBN
cord-347986-ds5hm731	57	8	so	so	RB
cord-347986-ds5hm731	57	9	much	much	JJ
cord-347986-ds5hm731	57	10	attention	attention	NN
cord-347986-ds5hm731	57	11	over	over	IN
cord-347986-ds5hm731	57	12	the	the	DT
cord-347986-ds5hm731	57	13	last	last	JJ
cord-347986-ds5hm731	57	14	several	several	JJ
cord-347986-ds5hm731	57	15	years	year	NNS
cord-347986-ds5hm731	57	16	does	do	VBZ
cord-347986-ds5hm731	57	17	NOT	not	RB
cord-347986-ds5hm731	57	18	presently	presently	RB
cord-347986-ds5hm731	57	19	meet	meet	VB
cord-347986-ds5hm731	57	20	the	the	DT
cord-347986-ds5hm731	57	21	criteria	criterion	NNS
cord-347986-ds5hm731	57	22	of	of	IN
cord-347986-ds5hm731	57	23	an	an	DT
cord-347986-ds5hm731	57	24	antigenically	antigenically	NN
cord-347986-ds5hm731	57	25	shifted	shift	VBN
cord-347986-ds5hm731	57	26	strain	strain	NN
cord-347986-ds5hm731	57	27	.	.	.
cord-347986-ds5hm731	58	1	It	-PRON-	PRP
cord-347986-ds5hm731	58	2	is	be	VBZ
cord-347986-ds5hm731	58	3	presently	presently	RB
cord-347986-ds5hm731	58	4	an	an	DT
cord-347986-ds5hm731	58	5	avian	avian	JJ
cord-347986-ds5hm731	58	6	strain	strain	NN
cord-347986-ds5hm731	58	7	that	that	WDT
cord-347986-ds5hm731	58	8	has	have	VBZ
cord-347986-ds5hm731	58	9	not	not	RB
cord-347986-ds5hm731	58	10	undergone	undergo	VBN
cord-347986-ds5hm731	58	11	reassortment	reassortment	NN
cord-347986-ds5hm731	58	12	with	with	IN
cord-347986-ds5hm731	58	13	a	a	DT
cord-347986-ds5hm731	58	14	human	human	JJ
cord-347986-ds5hm731	58	15	strain	strain	NN
cord-347986-ds5hm731	58	16	and	and	CC
cord-347986-ds5hm731	58	17	is	be	VBZ
cord-347986-ds5hm731	58	18	not	not	RB
cord-347986-ds5hm731	58	19	well	well	RB
cord-347986-ds5hm731	58	20	adapted	adapt	VBN
cord-347986-ds5hm731	58	21	to	to	IN
cord-347986-ds5hm731	58	22	humans	human	NNS
cord-347986-ds5hm731	58	23	.	.	.
cord-347986-ds5hm731	59	1	Only	only	RB
cord-347986-ds5hm731	59	2	a	a	DT
cord-347986-ds5hm731	59	3	small	small	JJ
cord-347986-ds5hm731	59	4	number	number	NN
cord-347986-ds5hm731	59	5	of	of	IN
cord-347986-ds5hm731	59	6	people	people	NNS
cord-347986-ds5hm731	59	7	(	(	-LRB-
cord-347986-ds5hm731	59	8	n	n	CC
cord-347986-ds5hm731	59	9	¼	¼	NNP
cord-347986-ds5hm731	59	10	204	204	CD
cord-347986-ds5hm731	59	11	,	,	,
cord-347986-ds5hm731	59	12	with	with	IN
cord-347986-ds5hm731	59	13	113	113	CD
cord-347986-ds5hm731	59	14	deaths	death	NNS
cord-347986-ds5hm731	59	15	)	)	-RRB-
cord-347986-ds5hm731	59	16	have	have	VBP
cord-347986-ds5hm731	59	17	been	be	VBN
cord-347986-ds5hm731	59	18	confirmed	confirm	VBN
cord-347986-ds5hm731	59	19	as	as	IN
cord-347986-ds5hm731	59	20	infected	infect	VBN
cord-347986-ds5hm731	59	21	to	to	IN
cord-347986-ds5hm731	59	22	date	date	NN
cord-347986-ds5hm731	59	23	,	,	,
cord-347986-ds5hm731	59	24	and	and	CC
cord-347986-ds5hm731	59	25	the	the	DT
cord-347986-ds5hm731	59	26	vast	vast	JJ
cord-347986-ds5hm731	59	27	majority	majority	NN
cord-347986-ds5hm731	59	28	of	of	IN
cord-347986-ds5hm731	59	29	these	these	DT
cord-347986-ds5hm731	59	30	individuals	individual	NNS
cord-347986-ds5hm731	59	31	apparently	apparently	RB
cord-347986-ds5hm731	59	32	acquired	acquire	VBD
cord-347986-ds5hm731	59	33	the	the	DT
cord-347986-ds5hm731	59	34	virus	virus	NN
cord-347986-ds5hm731	59	35	through	through	IN
cord-347986-ds5hm731	59	36	close	close	JJ
cord-347986-ds5hm731	59	37	contact	contact	NN
cord-347986-ds5hm731	59	38	with	with	IN
cord-347986-ds5hm731	59	39	infected	infected	JJ
cord-347986-ds5hm731	59	40	birds	bird	NNS
cord-347986-ds5hm731	59	41	and/or	and/or	CC
cord-347986-ds5hm731	59	42	consuming	consume	VBG
cord-347986-ds5hm731	59	43	undercooked	undercooked	JJ
cord-347986-ds5hm731	59	44	infected	infected	JJ
cord-347986-ds5hm731	59	45	bird	bird	NN
cord-347986-ds5hm731	59	46	products	product	NNS
cord-347986-ds5hm731	59	47	[	[	-LRB-
cord-347986-ds5hm731	59	48	1	1	CD
cord-347986-ds5hm731	59	49	,	,	,
cord-347986-ds5hm731	59	50	3	3	CD
cord-347986-ds5hm731	59	51	]	]	-RRB-
cord-347986-ds5hm731	59	52	.	.	.
cord-347986-ds5hm731	60	1	Still	still	RB
cord-347986-ds5hm731	60	2	the	the	DT
cord-347986-ds5hm731	60	3	increasing	increase	VBG
cord-347986-ds5hm731	60	4	geographic	geographic	JJ
cord-347986-ds5hm731	60	5	spread	spread	NN
cord-347986-ds5hm731	60	6	of	of	IN
cord-347986-ds5hm731	60	7	infected	infected	JJ
cord-347986-ds5hm731	60	8	birds	bird	NNS
cord-347986-ds5hm731	60	9	beyond	beyond	IN
cord-347986-ds5hm731	60	10	Asia	Asia	NNP
cord-347986-ds5hm731	60	11	to	to	IN
cord-347986-ds5hm731	60	12	Africa	Africa	NNP
cord-347986-ds5hm731	60	13	and	and	CC
cord-347986-ds5hm731	60	14	Europe	Europe	NNP
cord-347986-ds5hm731	60	15	,	,	,
cord-347986-ds5hm731	60	16	the	the	DT
cord-347986-ds5hm731	60	17	transmission	transmission	NN
cord-347986-ds5hm731	60	18	to	to	IN
cord-347986-ds5hm731	60	19	felids	felid	NNS
cord-347986-ds5hm731	60	20	(	(	-LRB-
cord-347986-ds5hm731	60	21	tigers	tiger	NNS
cord-347986-ds5hm731	60	22	and	and	CC
cord-347986-ds5hm731	60	23	leopards	leopard	NNS
cord-347986-ds5hm731	60	24	)	)	-RRB-
cord-347986-ds5hm731	60	25	through	through	IN
cord-347986-ds5hm731	60	26	consumption	consumption	NN
cord-347986-ds5hm731	60	27	of	of	IN
cord-347986-ds5hm731	60	28	raw	raw	JJ
cord-347986-ds5hm731	60	29	infected	infected	JJ
cord-347986-ds5hm731	60	30	chickens	chicken	NNS
cord-347986-ds5hm731	60	31	in	in	IN
cord-347986-ds5hm731	60	32	Thailand	Thailand	NNP
cord-347986-ds5hm731	60	33	,	,	,
cord-347986-ds5hm731	60	34	and	and	CC
cord-347986-ds5hm731	60	35	the	the	DT
cord-347986-ds5hm731	60	36	spread	spread	NN
cord-347986-ds5hm731	60	37	of	of	IN
cord-347986-ds5hm731	60	38	reported	report	VBN
cord-347986-ds5hm731	60	39	human	human	JJ
cord-347986-ds5hm731	60	40	cases	case	NNS
cord-347986-ds5hm731	60	41	from	from	IN
cord-347986-ds5hm731	60	42	Thailand	Thailand	NNP
cord-347986-ds5hm731	60	43	and	and	CC
cord-347986-ds5hm731	60	44	Viet	Viet	NNP
cord-347986-ds5hm731	60	45	Nam	Nam	NNP
cord-347986-ds5hm731	60	46	in	in	IN
cord-347986-ds5hm731	60	47	2004	2004	CD
cord-347986-ds5hm731	60	48	to	to	IN
cord-347986-ds5hm731	60	49	Cambodia	Cambodia	NNP
cord-347986-ds5hm731	60	50	,	,	,
cord-347986-ds5hm731	60	51	China	China	NNP
cord-347986-ds5hm731	60	52	and	and	CC
cord-347986-ds5hm731	60	53	Indonesia	Indonesia	NNP
cord-347986-ds5hm731	60	54	in	in	IN
cord-347986-ds5hm731	60	55	2005	2005	CD
cord-347986-ds5hm731	60	56	and	and	CC
cord-347986-ds5hm731	60	57	Azerbaijan	Azerbaijan	NNP
cord-347986-ds5hm731	60	58	,	,	,
cord-347986-ds5hm731	60	59	Egypt	Egypt	NNP
cord-347986-ds5hm731	60	60	,	,	,
cord-347986-ds5hm731	60	61	Iraq	Iraq	NNP
cord-347986-ds5hm731	60	62	,	,	,
cord-347986-ds5hm731	60	63	and	and	CC
cord-347986-ds5hm731	60	64	Turkey	Turkey	NNP
cord-347986-ds5hm731	60	65	in	in	IN
cord-347986-ds5hm731	60	66	2006	2006	CD
cord-347986-ds5hm731	60	67	,	,	,
cord-347986-ds5hm731	60	68	raises	raise	VBZ
cord-347986-ds5hm731	60	69	concerns	concern	NNS
cord-347986-ds5hm731	60	70	for	for	IN
cord-347986-ds5hm731	60	71	a	a	DT
cord-347986-ds5hm731	60	72	potential	potential	JJ
cord-347986-ds5hm731	60	73	pandemic	pandemic	NN
cord-347986-ds5hm731	60	74	should	should	MD
cord-347986-ds5hm731	60	75	further	further	VB
cord-347986-ds5hm731	60	76	adaptation	adaptation	NN
cord-347986-ds5hm731	60	77	to	to	IN
cord-347986-ds5hm731	60	78	humans	human	NNS
cord-347986-ds5hm731	60	79	occur	occur	VBP
cord-347986-ds5hm731	60	80	.	.	.
cord-347986-ds5hm731	61	1	In	in	IN
cord-347986-ds5hm731	61	2	the	the	DT
cord-347986-ds5hm731	61	3	event	event	NN
cord-347986-ds5hm731	61	4	of	of	IN
cord-347986-ds5hm731	61	5	such	such	PDT
cord-347986-ds5hm731	61	6	a	a	DT
cord-347986-ds5hm731	61	7	pandemic	pandemic	NN
cord-347986-ds5hm731	61	8	should	should	MD
cord-347986-ds5hm731	61	9	arise	arise	VB
cord-347986-ds5hm731	61	10	,	,	,
cord-347986-ds5hm731	61	11	where	where	WRB
cord-347986-ds5hm731	61	12	do	do	VBP
cord-347986-ds5hm731	61	13	we	-PRON-	PRP
cord-347986-ds5hm731	61	14	stand	stand	VB
cord-347986-ds5hm731	61	15	in	in	IN
cord-347986-ds5hm731	61	16	treating	treat	VBG
cord-347986-ds5hm731	61	17	and	and	CC
cord-347986-ds5hm731	61	18	preventing	prevent	VBG
cord-347986-ds5hm731	61	19	the	the	DT
cord-347986-ds5hm731	61	20	spread	spread	NN
cord-347986-ds5hm731	61	21	of	of	IN
cord-347986-ds5hm731	61	22	this	this	DT
cord-347986-ds5hm731	61	23	virus	virus	NN
cord-347986-ds5hm731	61	24	?	?	.
cord-347986-ds5hm731	62	1	Since	since	IN
cord-347986-ds5hm731	62	2	human	human	JJ
cord-347986-ds5hm731	62	3	influenza	influenza	NN
cord-347986-ds5hm731	62	4	A	a	NN
cord-347986-ds5hm731	62	5	(	(	-LRB-
cord-347986-ds5hm731	62	6	H5N1	H5N1	NNP
cord-347986-ds5hm731	62	7	)	)	-RRB-
cord-347986-ds5hm731	62	8	isolates	isolate	NNS
cord-347986-ds5hm731	62	9	are	be	VBP
cord-347986-ds5hm731	62	10	resistant	resistant	JJ
cord-347986-ds5hm731	62	11	to	to	IN
cord-347986-ds5hm731	62	12	the	the	DT
cord-347986-ds5hm731	62	13	M2	M2	NNP
cord-347986-ds5hm731	62	14	inhibitors	inhibitor	NNS
cord-347986-ds5hm731	62	15	amantadine	amantadine	NNP
cord-347986-ds5hm731	62	16	and	and	CC
cord-347986-ds5hm731	62	17	rimantadine	rimantadine	NNP
cord-347986-ds5hm731	62	18	,	,	,
cord-347986-ds5hm731	62	19	these	these	DT
cord-347986-ds5hm731	62	20	antivirals	antiviral	NNS
cord-347986-ds5hm731	62	21	do	do	VBP
cord-347986-ds5hm731	62	22	not	not	RB
cord-347986-ds5hm731	62	23	have	have	VB
cord-347986-ds5hm731	62	24	a	a	DT
cord-347986-ds5hm731	62	25	role	role	NN
cord-347986-ds5hm731	62	26	for	for	IN
cord-347986-ds5hm731	62	27	the	the	DT
cord-347986-ds5hm731	62	28	treatment	treatment	NN
cord-347986-ds5hm731	62	29	or	or	CC
cord-347986-ds5hm731	62	30	prophylaxis	prophylaxis	NN
cord-347986-ds5hm731	62	31	against	against	IN
cord-347986-ds5hm731	62	32	this	this	DT
cord-347986-ds5hm731	62	33	strain	strain	NN
cord-347986-ds5hm731	62	34	.	.	.
cord-347986-ds5hm731	63	1	The	the	DT
cord-347986-ds5hm731	63	2	neuraminidase	neuraminidase	NN
cord-347986-ds5hm731	63	3	inhibitors	inhibitor	NNS
cord-347986-ds5hm731	63	4	oseltamivir	oseltamivir	NNP
cord-347986-ds5hm731	63	5	,	,	,
cord-347986-ds5hm731	63	6	1	1	CD
cord-347986-ds5hm731	63	7	,	,	,
cord-347986-ds5hm731	63	8	and	and	CC
cord-347986-ds5hm731	63	9	zanamivir	zanamivir	NNP
cord-347986-ds5hm731	63	10	,	,	,
cord-347986-ds5hm731	63	11	2	2	CD
cord-347986-ds5hm731	63	12	,	,	,
cord-347986-ds5hm731	63	13	have	have	VBP
cord-347986-ds5hm731	63	14	in	in	FW
cord-347986-ds5hm731	63	15	vitro	vitro	FW
cord-347986-ds5hm731	63	16	activities	activity	NNS
cord-347986-ds5hm731	63	17	against	against	IN
cord-347986-ds5hm731	63	18	the	the	DT
cord-347986-ds5hm731	63	19	human	human	JJ
cord-347986-ds5hm731	63	20	H5N1	H5N1	NNP
cord-347986-ds5hm731	63	21	isolates	isolate	VBZ
cord-347986-ds5hm731	63	22	;	;	:
cord-347986-ds5hm731	63	23	however	however	RB
cord-347986-ds5hm731	63	24	,	,	,
cord-347986-ds5hm731	63	25	recent	recent	JJ
cord-347986-ds5hm731	63	26	data	datum	NNS
cord-347986-ds5hm731	63	27	suggest	suggest	VBP
cord-347986-ds5hm731	63	28	that	that	IN
cord-347986-ds5hm731	63	29	higher	high	JJR
cord-347986-ds5hm731	63	30	doses	dose	NNS
cord-347986-ds5hm731	63	31	for	for	IN
cord-347986-ds5hm731	63	32	longer	long	JJR
cord-347986-ds5hm731	63	33	periods	period	NNS
cord-347986-ds5hm731	63	34	(	(	-LRB-
cord-347986-ds5hm731	63	35	7	7	CD
cord-347986-ds5hm731	63	36	-	-	SYM
cord-347986-ds5hm731	63	37	10	10	CD
cord-347986-ds5hm731	63	38	days	day	NNS
cord-347986-ds5hm731	63	39	vs.	vs.	IN
cord-347986-ds5hm731	63	40	the	the	DT
cord-347986-ds5hm731	63	41	prior	prior	JJ
cord-347986-ds5hm731	63	42	recommendation	recommendation	NN
cord-347986-ds5hm731	63	43	of	of	IN
cord-347986-ds5hm731	63	44	five	five	CD
cord-347986-ds5hm731	63	45	days	day	NNS
cord-347986-ds5hm731	63	46	)	)	-RRB-
cord-347986-ds5hm731	63	47	may	may	MD
cord-347986-ds5hm731	63	48	be	be	VB
cord-347986-ds5hm731	63	49	required	require	VBN
cord-347986-ds5hm731	63	50	to	to	TO
cord-347986-ds5hm731	63	51	be	be	VB
cord-347986-ds5hm731	63	52	effective	effective	JJ
cord-347986-ds5hm731	63	53	[	[	-LRB-
cord-347986-ds5hm731	63	54	4	4	CD
cord-347986-ds5hm731	63	55	]	]	-RRB-
cord-347986-ds5hm731	63	56	.	.	.
cord-347986-ds5hm731	64	1	Oseltamivir	Oseltamivir	NNP
cord-347986-ds5hm731	64	2	is	be	VBZ
cord-347986-ds5hm731	64	3	an	an	DT
cord-347986-ds5hm731	64	4	oral	oral	JJ
cord-347986-ds5hm731	64	5	agent	agent	NN
cord-347986-ds5hm731	64	6	approved	approve	VBN
cord-347986-ds5hm731	64	7	for	for	IN
cord-347986-ds5hm731	64	8	prophylaxis	prophylaxis	NN
cord-347986-ds5hm731	64	9	and	and	CC
cord-347986-ds5hm731	64	10	treatment	treatment	NN
cord-347986-ds5hm731	64	11	of	of	IN
cord-347986-ds5hm731	64	12	influenza	influenza	NN
cord-347986-ds5hm731	64	13	infections	infection	NNS
cord-347986-ds5hm731	64	14	.	.	.
cord-347986-ds5hm731	65	1	Zanamivir	Zanamivir	NNP
cord-347986-ds5hm731	65	2	is	be	VBZ
cord-347986-ds5hm731	65	3	delivered	deliver	VBN
cord-347986-ds5hm731	65	4	topically	topically	RB
cord-347986-ds5hm731	65	5	to	to	IN
cord-347986-ds5hm731	65	6	the	the	DT
cord-347986-ds5hm731	65	7	respiratory	respiratory	JJ
cord-347986-ds5hm731	65	8	tract	tract	NN
cord-347986-ds5hm731	65	9	with	with	IN
cord-347986-ds5hm731	65	10	similar	similar	JJ
cord-347986-ds5hm731	65	11	indications	indication	NNS
cord-347986-ds5hm731	65	12	.	.	.
cord-347986-ds5hm731	66	1	Oseltamivir	Oseltamivir	NNP
cord-347986-ds5hm731	66	2	resistance	resistance	NN
cord-347986-ds5hm731	66	3	in	in	IN
cord-347986-ds5hm731	66	4	human	human	JJ
cord-347986-ds5hm731	66	5	isolates	isolate	NNS
cord-347986-ds5hm731	66	6	from	from	IN
cord-347986-ds5hm731	66	7	Viet	Viet	NNP
cord-347986-ds5hm731	66	8	Nam	Nam	NNP
cord-347986-ds5hm731	66	9	has	have	VBZ
cord-347986-ds5hm731	66	10	been	be	VBN
cord-347986-ds5hm731	66	11	noted	note	VBN
cord-347986-ds5hm731	66	12	[	[	-LRB-
cord-347986-ds5hm731	66	13	5	5	CD
cord-347986-ds5hm731	66	14	,	,	,
cord-347986-ds5hm731	66	15	6	6	CD
cord-347986-ds5hm731	66	16	]	]	-RRB-
cord-347986-ds5hm731	66	17	.	.	.
cord-347986-ds5hm731	67	1	These	these	DT
cord-347986-ds5hm731	67	2	strains	strain	NNS
cord-347986-ds5hm731	67	3	may	may	MD
cord-347986-ds5hm731	67	4	not	not	RB
cord-347986-ds5hm731	67	5	be	be	VB
cord-347986-ds5hm731	67	6	resistant	resistant	JJ
cord-347986-ds5hm731	67	7	to	to	IN
cord-347986-ds5hm731	67	8	zanamivir	zanamivir	NNP
cord-347986-ds5hm731	67	9	[	[	-LRB-
cord-347986-ds5hm731	67	10	6	6	CD
cord-347986-ds5hm731	67	11	]	]	-RRB-
cord-347986-ds5hm731	67	12	.	.	.
cord-347986-ds5hm731	68	1	Stockpiles	stockpile	NNS
cord-347986-ds5hm731	68	2	of	of	IN
cord-347986-ds5hm731	68	3	drug	drug	NN
cord-347986-ds5hm731	68	4	will	will	MD
cord-347986-ds5hm731	68	5	be	be	VB
cord-347986-ds5hm731	68	6	needed	need	VBN
cord-347986-ds5hm731	68	7	for	for	IN
cord-347986-ds5hm731	68	8	prophylaxis	prophylaxis	NN
cord-347986-ds5hm731	68	9	and	and	CC
cord-347986-ds5hm731	68	10	treatment	treatment	NN
cord-347986-ds5hm731	68	11	if	if	IN
cord-347986-ds5hm731	68	12	they	-PRON-	PRP
cord-347986-ds5hm731	68	13	are	be	VBP
cord-347986-ds5hm731	68	14	to	to	TO
cord-347986-ds5hm731	68	15	be	be	VB
cord-347986-ds5hm731	68	16	used	use	VBN
cord-347986-ds5hm731	68	17	in	in	IN
cord-347986-ds5hm731	68	18	the	the	DT
cord-347986-ds5hm731	68	19	event	event	NN
cord-347986-ds5hm731	68	20	of	of	IN
cord-347986-ds5hm731	68	21	a	a	DT
cord-347986-ds5hm731	68	22	new	new	JJ
cord-347986-ds5hm731	68	23	pandemic	pandemic	NN
cord-347986-ds5hm731	68	24	.	.	.
cord-347986-ds5hm731	69	1	A	a	DT
cord-347986-ds5hm731	69	2	long	long	RB
cord-347986-ds5hm731	69	3	-	-	HYPH
cord-347986-ds5hm731	69	4	acting	act	VBG
cord-347986-ds5hm731	69	5	neuraminidase	neuraminidase	JJ
cord-347986-ds5hm731	69	6	inhibitor	inhibitor	NN
cord-347986-ds5hm731	69	7	,	,	,
cord-347986-ds5hm731	69	8	peramivir	peramivir	NNP
cord-347986-ds5hm731	69	9	,	,	,
cord-347986-ds5hm731	69	10	3	3	CD
cord-347986-ds5hm731	69	11	,	,	,
cord-347986-ds5hm731	69	12	has	have	VBZ
cord-347986-ds5hm731	69	13	begun	begin	VBN
cord-347986-ds5hm731	69	14	Phase	phase	NN
cord-347986-ds5hm731	70	1	I	-PRON-	PRP
cord-347986-ds5hm731	70	2	clinical	clinical	JJ
cord-347986-ds5hm731	70	3	trial	trial	NN
cord-347986-ds5hm731	70	4	to	to	TO
cord-347986-ds5hm731	70	5	begin	begin	VB
cord-347986-ds5hm731	70	6	to	to	TO
cord-347986-ds5hm731	70	7	determine	determine	VB
cord-347986-ds5hm731	70	8	whether	whether	IN
cord-347986-ds5hm731	70	9	it	-PRON-	PRP
cord-347986-ds5hm731	70	10	may	may	MD
cord-347986-ds5hm731	70	11	be	be	VB
cord-347986-ds5hm731	70	12	an	an	DT
cord-347986-ds5hm731	70	13	intravenous	intravenous	JJ
cord-347986-ds5hm731	70	14	option	option	NN
cord-347986-ds5hm731	70	15	for	for	IN
cord-347986-ds5hm731	70	16	this	this	DT
cord-347986-ds5hm731	70	17	disease	disease	NN
cord-347986-ds5hm731	71	1	[	[	-LRB-
cord-347986-ds5hm731	71	2	 	 	_SP
cord-347986-ds5hm731	71	3	Traditionally	traditionally	RB
cord-347986-ds5hm731	71	4	,	,	,
cord-347986-ds5hm731	71	5	vaccination	vaccination	NN
cord-347986-ds5hm731	71	6	has	have	VBZ
cord-347986-ds5hm731	71	7	been	be	VBN
cord-347986-ds5hm731	71	8	the	the	DT
cord-347986-ds5hm731	71	9	principal	principal	JJ
cord-347986-ds5hm731	71	10	approach	approach	NN
cord-347986-ds5hm731	71	11	to	to	IN
cord-347986-ds5hm731	71	12	protecting	protect	VBG
cord-347986-ds5hm731	71	13	individuals	individual	NNS
cord-347986-ds5hm731	71	14	against	against	IN
cord-347986-ds5hm731	71	15	influenza	influenza	NN
cord-347986-ds5hm731	71	16	.	.	.
cord-347986-ds5hm731	72	1	Currently	currently	RB
cord-347986-ds5hm731	72	2	,	,	,
cord-347986-ds5hm731	72	3	no	no	DT
cord-347986-ds5hm731	72	4	influenza	influenza	NN
cord-347986-ds5hm731	72	5	A	a	DT
cord-347986-ds5hm731	72	6	H5N1	H5N1	NNP
cord-347986-ds5hm731	72	7	vaccine	vaccine	NN
cord-347986-ds5hm731	72	8	is	be	VBZ
cord-347986-ds5hm731	72	9	available	available	JJ
cord-347986-ds5hm731	72	10	although	although	IN
cord-347986-ds5hm731	72	11	several	several	JJ
cord-347986-ds5hm731	72	12	candidate	candidate	NN
cord-347986-ds5hm731	72	13	vaccines	vaccine	NNS
cord-347986-ds5hm731	72	14	are	be	VBP
cord-347986-ds5hm731	72	15	being	be	VBG
cord-347986-ds5hm731	72	16	developed	develop	VBN
cord-347986-ds5hm731	72	17	.	.	.
cord-347986-ds5hm731	73	1	Preliminary	preliminary	JJ
cord-347986-ds5hm731	73	2	data	datum	NNS
cord-347986-ds5hm731	73	3	suggest	suggest	VBP
cord-347986-ds5hm731	73	4	that	that	IN
cord-347986-ds5hm731	73	5	either	either	CC
cord-347986-ds5hm731	73	6	higher	high	JJR
cord-347986-ds5hm731	73	7	concentrations	concentration	NNS
cord-347986-ds5hm731	73	8	of	of	IN
cord-347986-ds5hm731	73	9	antigens	antigen	NNS
cord-347986-ds5hm731	73	10	than	than	IN
cord-347986-ds5hm731	73	11	used	use	VBN
cord-347986-ds5hm731	73	12	in	in	IN
cord-347986-ds5hm731	73	13	seasonal	seasonal	JJ
cord-347986-ds5hm731	73	14	influenza	influenza	NN
cord-347986-ds5hm731	73	15	vaccines	vaccine	NNS
cord-347986-ds5hm731	73	16	and/or	and/or	CC
cord-347986-ds5hm731	73	17	addition	addition	NN
cord-347986-ds5hm731	73	18	of	of	IN
cord-347986-ds5hm731	73	19	adjuvants	adjuvant	NNS
cord-347986-ds5hm731	73	20	to	to	IN
cord-347986-ds5hm731	73	21	these	these	DT
cord-347986-ds5hm731	73	22	vaccines	vaccine	NNS
cord-347986-ds5hm731	73	23	will	will	MD
cord-347986-ds5hm731	73	24	be	be	VB
cord-347986-ds5hm731	73	25	necessary	necessary	JJ
cord-347986-ds5hm731	73	26	to	to	TO
cord-347986-ds5hm731	73	27	induce	induce	VB
cord-347986-ds5hm731	73	28	protective	protective	JJ
cord-347986-ds5hm731	73	29	responses	response	NNS
cord-347986-ds5hm731	73	30	[	[	-LRB-
cord-347986-ds5hm731	73	31	8	8	CD
cord-347986-ds5hm731	73	32	]	]	-RRB-
cord-347986-ds5hm731	73	33	.	.	.
cord-347986-ds5hm731	74	1	Gearing	gear	VBG
cord-347986-ds5hm731	74	2	production	production	NN
cord-347986-ds5hm731	74	3	,	,	,
cord-347986-ds5hm731	74	4	to	to	TO
cord-347986-ds5hm731	74	5	rapidly	rapidly	RB
cord-347986-ds5hm731	74	6	make	make	VB
cord-347986-ds5hm731	74	7	necessary	necessary	JJ
cord-347986-ds5hm731	74	8	quantities	quantity	NNS
cord-347986-ds5hm731	74	9	,	,	,
cord-347986-ds5hm731	74	10	of	of	IN
cord-347986-ds5hm731	74	11	such	such	PDT
cord-347986-ds5hm731	74	12	a	a	DT
cord-347986-ds5hm731	74	13	vaccine	vaccine	NN
cord-347986-ds5hm731	74	14	in	in	IN
cord-347986-ds5hm731	74	15	the	the	DT
cord-347986-ds5hm731	74	16	event	event	NN
cord-347986-ds5hm731	74	17	of	of	IN
cord-347986-ds5hm731	74	18	pandemic	pandemic	NN
cord-347986-ds5hm731	74	19	spread	spread	NN
cord-347986-ds5hm731	74	20	will	will	MD
cord-347986-ds5hm731	74	21	be	be	VB
cord-347986-ds5hm731	74	22	a	a	DT
cord-347986-ds5hm731	74	23	great	great	JJ
cord-347986-ds5hm731	74	24	challenge	challenge	NN
cord-347986-ds5hm731	74	25	to	to	IN
cord-347986-ds5hm731	74	26	the	the	DT
cord-347986-ds5hm731	74	27	vaccine	vaccine	NN
cord-347986-ds5hm731	74	28	industry	industry	NN
cord-347986-ds5hm731	74	29	.	.	.
cord-347986-ds5hm731	75	1	Thus	thus	RB
cord-347986-ds5hm731	75	2	,	,	,
cord-347986-ds5hm731	75	3	although	although	IN
cord-347986-ds5hm731	75	4	great	great	JJ
cord-347986-ds5hm731	75	5	progress	progress	NN
cord-347986-ds5hm731	75	6	has	have	VBZ
cord-347986-ds5hm731	75	7	been	be	VBN
cord-347986-ds5hm731	75	8	made	make	VBN
cord-347986-ds5hm731	75	9	in	in	IN
cord-347986-ds5hm731	75	10	understanding	understand	VBG
cord-347986-ds5hm731	75	11	the	the	DT
cord-347986-ds5hm731	75	12	biology	biology	NN
cord-347986-ds5hm731	75	13	of	of	IN
cord-347986-ds5hm731	75	14	avian	avian	JJ
cord-347986-ds5hm731	75	15	influenza	influenza	NN
cord-347986-ds5hm731	75	16	H5N1	H5N1	NNP
cord-347986-ds5hm731	75	17	and	and	CC
cord-347986-ds5hm731	75	18	although	although	IN
cord-347986-ds5hm731	75	19	the	the	DT
cord-347986-ds5hm731	75	20	virus	virus	NN
cord-347986-ds5hm731	75	21	is	be	VBZ
cord-347986-ds5hm731	75	22	not	not	RB
cord-347986-ds5hm731	75	23	presently	presently	RB
cord-347986-ds5hm731	75	24	capable	capable	JJ
cord-347986-ds5hm731	75	25	of	of	IN
cord-347986-ds5hm731	75	26	efficient	efficient	JJ
cord-347986-ds5hm731	75	27	human	human	NN
cord-347986-ds5hm731	75	28	-	-	HYPH
cord-347986-ds5hm731	75	29	to	to	IN
cord-347986-ds5hm731	75	30	-	-	HYPH
cord-347986-ds5hm731	75	31	human	human	JJ
cord-347986-ds5hm731	75	32	transmission	transmission	NN
cord-347986-ds5hm731	75	33	there	there	EX
cord-347986-ds5hm731	75	34	is	be	VBZ
cord-347986-ds5hm731	75	35	reason	reason	NN
cord-347986-ds5hm731	75	36	for	for	IN
cord-347986-ds5hm731	75	37	concern	concern	NN
cord-347986-ds5hm731	75	38	as	as	IN
cord-347986-ds5hm731	75	39	noted	note	VBN
cord-347986-ds5hm731	75	40	above	above	RB
cord-347986-ds5hm731	75	41	.	.	.
cord-347986-ds5hm731	76	1	Continued	continue	VBN
cord-347986-ds5hm731	76	2	surveillance	surveillance	NN
cord-347986-ds5hm731	76	3	in	in	IN
cord-347986-ds5hm731	76	4	animal	animal	NN
cord-347986-ds5hm731	76	5	and	and	CC
cord-347986-ds5hm731	76	6	human	human	JJ
cord-347986-ds5hm731	76	7	populations	population	NNS
cord-347986-ds5hm731	76	8	and	and	CC
cord-347986-ds5hm731	76	9	infection	infection	NN
cord-347986-ds5hm731	76	10	control	control	NN
cord-347986-ds5hm731	76	11	measures	measure	NNS
cord-347986-ds5hm731	76	12	to	to	TO
cord-347986-ds5hm731	76	13	limit	limit	VB
cord-347986-ds5hm731	76	14	its	-PRON-	PRP$
cord-347986-ds5hm731	76	15	spread	spread	NN
cord-347986-ds5hm731	76	16	are	be	VBP
cord-347986-ds5hm731	76	17	critical	critical	JJ
cord-347986-ds5hm731	76	18	,	,	,
cord-347986-ds5hm731	76	19	while	while	IN
cord-347986-ds5hm731	76	20	we	-PRON-	PRP
cord-347986-ds5hm731	76	21	learn	learn	VBP
cord-347986-ds5hm731	76	22	to	to	TO
cord-347986-ds5hm731	76	23	better	well	JJR
cord-347986-ds5hm731	76	24	combat	combat	VB
cord-347986-ds5hm731	76	25	this	this	DT
cord-347986-ds5hm731	76	26	virus	virus	NN
cord-347986-ds5hm731	76	27	(	(	-LRB-
cord-347986-ds5hm731	76	28	or	or	CC
cord-347986-ds5hm731	76	29	some	some	DT
cord-347986-ds5hm731	76	30	other	other	JJ
cord-347986-ds5hm731	76	31	future	future	JJ
cord-347986-ds5hm731	76	32	strain	strain	NN
cord-347986-ds5hm731	76	33	)	)	-RRB-
cord-347986-ds5hm731	76	34	with	with	IN
cord-347986-ds5hm731	76	35	pandemic	pandemic	NN
cord-347986-ds5hm731	76	36	potential	potential	NN
cord-347986-ds5hm731	76	37	.	.	.
cord-347986-ds5hm731	77	1	In	in	IN
cord-347986-ds5hm731	77	2	1952	1952	CD
cord-347986-ds5hm731	77	3	,	,	,
cord-347986-ds5hm731	77	4	when	when	WRB
cord-347986-ds5hm731	77	5	Selman	Selman	NNP
cord-347986-ds5hm731	77	6	Waksman	Waksman	NNP
cord-347986-ds5hm731	77	7	received	receive	VBD
cord-347986-ds5hm731	77	8	the	the	DT
cord-347986-ds5hm731	77	9	Nobel	Nobel	NNP
cord-347986-ds5hm731	77	10	Prize	Prize	NNP
cord-347986-ds5hm731	77	11	for	for	IN
cord-347986-ds5hm731	77	12	his	-PRON-	PRP$
cord-347986-ds5hm731	77	13	discovery	discovery	NN
cord-347986-ds5hm731	77	14	of	of	IN
cord-347986-ds5hm731	77	15	streptomycin	streptomycin	NNS
cord-347986-ds5hm731	77	16	,	,	,
cord-347986-ds5hm731	77	17	the	the	DT
cord-347986-ds5hm731	77	18	first	first	JJ
cord-347986-ds5hm731	77	19	effective	effective	JJ
cord-347986-ds5hm731	77	20	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	77	21	drug	drug	NN
cord-347986-ds5hm731	77	22	,	,	,
cord-347986-ds5hm731	77	23	he	-PRON-	PRP
cord-347986-ds5hm731	77	24	proclaimed	proclaim	VBD
cord-347986-ds5hm731	77	25	that	that	IN
cord-347986-ds5hm731	77	26	the	the	DT
cord-347986-ds5hm731	77	27	conquest	conquest	NN
cord-347986-ds5hm731	77	28	of	of	IN
cord-347986-ds5hm731	77	29	the	the	DT
cord-347986-ds5hm731	77	30	'	'	``
cord-347986-ds5hm731	77	31	'	'	``
cord-347986-ds5hm731	77	32	Great	great	JJ
cord-347986-ds5hm731	77	33	White	White	NNP
cord-347986-ds5hm731	77	34	Plague	Plague	NNP
cord-347986-ds5hm731	77	35	'	'	''
cord-347986-ds5hm731	77	36	'	'	''
cord-347986-ds5hm731	77	37	,	,	,
cord-347986-ds5hm731	77	38	which	which	WDT
cord-347986-ds5hm731	77	39	was	be	VBD
cord-347986-ds5hm731	77	40	previously	previously	RB
cord-347986-ds5hm731	77	41	incurable	incurable	JJ
cord-347986-ds5hm731	77	42	and	and	CC
cord-347986-ds5hm731	77	43	associated	associate	VBN
cord-347986-ds5hm731	77	44	with	with	IN
cord-347986-ds5hm731	77	45	up	up	IN
cord-347986-ds5hm731	77	46	to	to	TO
cord-347986-ds5hm731	77	47	50	50	CD
cord-347986-ds5hm731	77	48	%	%	NN
cord-347986-ds5hm731	77	49	mortality	mortality	NN
cord-347986-ds5hm731	77	50	,	,	,
cord-347986-ds5hm731	77	51	was	be	VBD
cord-347986-ds5hm731	77	52	in	in	IN
cord-347986-ds5hm731	77	53	sight	sight	NN
cord-347986-ds5hm731	77	54	.	.	.
cord-347986-ds5hm731	78	1	Five	five	CD
cord-347986-ds5hm731	78	2	decades	decade	NNS
cord-347986-ds5hm731	78	3	later	later	RB
cord-347986-ds5hm731	78	4	,	,	,
cord-347986-ds5hm731	78	5	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	78	6	remains	remain	VBZ
cord-347986-ds5hm731	78	7	a	a	DT
cord-347986-ds5hm731	78	8	global	global	JJ
cord-347986-ds5hm731	78	9	epidemic	epidemic	NN
cord-347986-ds5hm731	78	10	and	and	CC
cord-347986-ds5hm731	78	11	currently	currently	RB
cord-347986-ds5hm731	78	12	affects	affect	VBZ
cord-347986-ds5hm731	78	13	2	2	CD
cord-347986-ds5hm731	78	14	billion	billion	CD
cord-347986-ds5hm731	78	15	people	people	NNS
cord-347986-ds5hm731	78	16	,	,	,
cord-347986-ds5hm731	78	17	or	or	CC
cord-347986-ds5hm731	78	18	1/3	1/3	CD
cord-347986-ds5hm731	78	19	of	of	IN
cord-347986-ds5hm731	78	20	the	the	DT
cord-347986-ds5hm731	78	21	world	world	NN
cord-347986-ds5hm731	78	22	's	's	POS
cord-347986-ds5hm731	78	23	population	population	NN
cord-347986-ds5hm731	78	24	,	,	,
cord-347986-ds5hm731	78	25	killing	kill	VBG
cord-347986-ds5hm731	78	26	2	2	CD
cord-347986-ds5hm731	78	27	million	million	CD
cord-347986-ds5hm731	78	28	of	of	IN
cord-347986-ds5hm731	78	29	them	-PRON-	PRP
cord-347986-ds5hm731	78	30	annually	annually	RB
cord-347986-ds5hm731	78	31	.	.	.
cord-347986-ds5hm731	79	1	The	the	DT
cord-347986-ds5hm731	79	2	World	World	NNP
cord-347986-ds5hm731	79	3	Health	Health	NNP
cord-347986-ds5hm731	79	4	Organization	Organization	NNP
cord-347986-ds5hm731	79	5	(	(	-LRB-
cord-347986-ds5hm731	79	6	WHO	who	WP
cord-347986-ds5hm731	79	7	)	)	-RRB-
cord-347986-ds5hm731	79	8	reports	report	VBZ
cord-347986-ds5hm731	79	9	that	that	IN
cord-347986-ds5hm731	79	10	new	new	JJ
cord-347986-ds5hm731	79	11	infections	infection	NNS
cord-347986-ds5hm731	79	12	are	be	VBP
cord-347986-ds5hm731	79	13	increasing	increase	VBG
cord-347986-ds5hm731	79	14	by	by	IN
cord-347986-ds5hm731	79	15	1	1	CD
cord-347986-ds5hm731	79	16	%	%	NN
cord-347986-ds5hm731	79	17	per	per	IN
cord-347986-ds5hm731	79	18	year	year	NN
cord-347986-ds5hm731	79	19	.	.	.
cord-347986-ds5hm731	80	1	By	by	IN
cord-347986-ds5hm731	80	2	2020	2020	CD
cord-347986-ds5hm731	80	3	,	,	,
cord-347986-ds5hm731	80	4	WHO	who	WP
cord-347986-ds5hm731	80	5	predicts	predict	VBZ
cord-347986-ds5hm731	80	6	there	there	EX
cord-347986-ds5hm731	80	7	will	will	MD
cord-347986-ds5hm731	80	8	be	be	VB
cord-347986-ds5hm731	80	9	1	1	CD
cord-347986-ds5hm731	80	10	billion	billion	CD
cord-347986-ds5hm731	80	11	new	new	JJ
cord-347986-ds5hm731	80	12	infections	infection	NNS
cord-347986-ds5hm731	80	13	,	,	,
cord-347986-ds5hm731	80	14	200	200	CD
cord-347986-ds5hm731	80	15	million	million	CD
cord-347986-ds5hm731	80	16	of	of	IN
cord-347986-ds5hm731	80	17	who	who	WP
cord-347986-ds5hm731	80	18	will	will	MD
cord-347986-ds5hm731	80	19	develop	develop	VB
cord-347986-ds5hm731	80	20	active	active	JJ
cord-347986-ds5hm731	80	21	disease	disease	NN
cord-347986-ds5hm731	80	22	,	,	,
cord-347986-ds5hm731	80	23	and	and	CC
cord-347986-ds5hm731	80	24	35	35	CD
cord-347986-ds5hm731	80	25	million	million	CD
cord-347986-ds5hm731	80	26	deaths	death	NNS
cord-347986-ds5hm731	80	27	caused	cause	VBN
cord-347986-ds5hm731	80	28	by	by	IN
cord-347986-ds5hm731	80	29	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	80	30	[	[	-LRB-
cord-347986-ds5hm731	80	31	9	9	CD
cord-347986-ds5hm731	80	32	]	]	-RRB-
cord-347986-ds5hm731	80	33	.	.	.
cord-347986-ds5hm731	81	1	Tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	81	2	is	be	VBZ
cord-347986-ds5hm731	81	3	a	a	DT
cord-347986-ds5hm731	81	4	particularly	particularly	RB
cord-347986-ds5hm731	81	5	frustrating	frustrating	JJ
cord-347986-ds5hm731	81	6	disease	disease	NN
cord-347986-ds5hm731	81	7	to	to	TO
cord-347986-ds5hm731	81	8	cure	cure	VB
cord-347986-ds5hm731	81	9	because	because	IN
cord-347986-ds5hm731	81	10	of	of	IN
cord-347986-ds5hm731	81	11	a	a	DT
cord-347986-ds5hm731	81	12	multitude	multitude	NN
cord-347986-ds5hm731	81	13	of	of	IN
cord-347986-ds5hm731	81	14	confounding	confounding	JJ
cord-347986-ds5hm731	81	15	factors	factor	NNS
cord-347986-ds5hm731	81	16	.	.	.
cord-347986-ds5hm731	82	1	In	in	IN
cord-347986-ds5hm731	82	2	fact	fact	NN
cord-347986-ds5hm731	82	3	,	,	,
cord-347986-ds5hm731	82	4	one	one	CD
cord-347986-ds5hm731	82	5	of	of	IN
cord-347986-ds5hm731	82	6	the	the	DT
cord-347986-ds5hm731	82	7	greatest	great	JJS
cord-347986-ds5hm731	82	8	ironies	irony	NNS
cord-347986-ds5hm731	82	9	is	be	VBZ
cord-347986-ds5hm731	82	10	that	that	IN
cord-347986-ds5hm731	82	11	the	the	DT
cord-347986-ds5hm731	82	12	majority	majority	NN
cord-347986-ds5hm731	82	13	of	of	IN
cord-347986-ds5hm731	82	14	antibiotics	antibiotic	NNS
cord-347986-ds5hm731	82	15	used	use	VBN
cord-347986-ds5hm731	82	16	to	to	TO
cord-347986-ds5hm731	82	17	treat	treat	VB
cord-347986-ds5hm731	82	18	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	82	19	are	be	VBP
cord-347986-ds5hm731	82	20	still	still	RB
cord-347986-ds5hm731	82	21	very	very	RB
cord-347986-ds5hm731	82	22	effective	effective	JJ
cord-347986-ds5hm731	82	23	.	.	.
cord-347986-ds5hm731	83	1	However	however	RB
cord-347986-ds5hm731	83	2	,	,	,
cord-347986-ds5hm731	83	3	successful	successful	JJ
cord-347986-ds5hm731	83	4	treatment	treatment	NN
cord-347986-ds5hm731	83	5	requires	require	VBZ
cord-347986-ds5hm731	83	6	a	a	DT
cord-347986-ds5hm731	83	7	combination	combination	NN
cord-347986-ds5hm731	83	8	of	of	IN
cord-347986-ds5hm731	83	9	multiple	multiple	JJ
cord-347986-ds5hm731	83	10	drugs	drug	NNS
cord-347986-ds5hm731	83	11	for	for	IN
cord-347986-ds5hm731	83	12	at	at	RB
cord-347986-ds5hm731	83	13	least	least	JJS
cord-347986-ds5hm731	83	14	six	six	CD
cord-347986-ds5hm731	83	15	months	month	NNS
cord-347986-ds5hm731	83	16	.	.	.
cord-347986-ds5hm731	84	1	The	the	DT
cord-347986-ds5hm731	84	2	majority	majority	NN
cord-347986-ds5hm731	84	3	(	(	-LRB-
cord-347986-ds5hm731	84	4	95	95	CD
cord-347986-ds5hm731	84	5	%	%	NN
cord-347986-ds5hm731	84	6	)	)	-RRB-
cord-347986-ds5hm731	84	7	of	of	IN
cord-347986-ds5hm731	84	8	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	84	9	occurs	occur	VBZ
cord-347986-ds5hm731	84	10	in	in	IN
cord-347986-ds5hm731	84	11	the	the	DT
cord-347986-ds5hm731	84	12	developing	develop	VBG
cord-347986-ds5hm731	84	13	world	world	NN
cord-347986-ds5hm731	84	14	,	,	,
cord-347986-ds5hm731	84	15	where	where	WRB
cord-347986-ds5hm731	84	16	the	the	DT
cord-347986-ds5hm731	84	17	high	high	JJ
cord-347986-ds5hm731	84	18	relative	relative	JJ
cord-347986-ds5hm731	84	19	cost	cost	NN
cord-347986-ds5hm731	84	20	,	,	,
cord-347986-ds5hm731	84	21	poor	poor	JJ
cord-347986-ds5hm731	84	22	accessibility	accessibility	NN
cord-347986-ds5hm731	84	23	of	of	IN
cord-347986-ds5hm731	84	24	medications	medication	NNS
cord-347986-ds5hm731	84	25	,	,	,
cord-347986-ds5hm731	84	26	and	and	CC
cord-347986-ds5hm731	84	27	weak	weak	JJ
cord-347986-ds5hm731	84	28	health	health	NN
cord-347986-ds5hm731	84	29	infrastructure	infrastructure	NN
cord-347986-ds5hm731	84	30	causes	cause	VBZ
cord-347986-ds5hm731	84	31	poor	poor	JJ
cord-347986-ds5hm731	84	32	compliance	compliance	NN
cord-347986-ds5hm731	84	33	and	and	CC
cord-347986-ds5hm731	84	34	subsequent	subsequent	JJ
cord-347986-ds5hm731	84	35	selection	selection	NN
cord-347986-ds5hm731	84	36	of	of	IN
cord-347986-ds5hm731	84	37	resistant	resistant	JJ
cord-347986-ds5hm731	84	38	strains	strain	NNS
cord-347986-ds5hm731	84	39	of	of	IN
cord-347986-ds5hm731	84	40	M.	M.	NNP
cord-347986-ds5hm731	84	41	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	84	42	to	to	IN
cord-347986-ds5hm731	84	43	the	the	DT
cord-347986-ds5hm731	84	44	drugs	drug	NNS
cord-347986-ds5hm731	84	45	it	-PRON-	PRP
cord-347986-ds5hm731	84	46	was	be	VBD
cord-347986-ds5hm731	84	47	exposed	expose	VBN
cord-347986-ds5hm731	84	48	to	to	IN
cord-347986-ds5hm731	84	49	.	.	.
cord-347986-ds5hm731	85	1	Two	two	CD
cord-347986-ds5hm731	85	2	-	-	HYPH
cord-347986-ds5hm731	85	3	thirds	third	NNS
cord-347986-ds5hm731	85	4	of	of	IN
cord-347986-ds5hm731	85	5	people	people	NNS
cord-347986-ds5hm731	85	6	with	with	IN
cord-347986-ds5hm731	85	7	TB	TB	NNP
cord-347986-ds5hm731	85	8	do	do	VBP
cord-347986-ds5hm731	85	9	not	not	RB
cord-347986-ds5hm731	85	10	have	have	VB
cord-347986-ds5hm731	85	11	access	access	NN
cord-347986-ds5hm731	85	12	to	to	IN
cord-347986-ds5hm731	85	13	effective	effective	JJ
cord-347986-ds5hm731	85	14	therapy	therapy	NN
cord-347986-ds5hm731	85	15	.	.	.
cord-347986-ds5hm731	86	1	But	but	CC
cord-347986-ds5hm731	86	2	even	even	RB
cord-347986-ds5hm731	86	3	when	when	WRB
cord-347986-ds5hm731	86	4	therapy	therapy	NN
cord-347986-ds5hm731	86	5	is	be	VBZ
cord-347986-ds5hm731	86	6	available	available	JJ
cord-347986-ds5hm731	86	7	and	and	CC
cord-347986-ds5hm731	86	8	properly	properly	RB
cord-347986-ds5hm731	86	9	utilized	utilize	VBN
cord-347986-ds5hm731	86	10	,	,	,
cord-347986-ds5hm731	86	11	it	-PRON-	PRP
cord-347986-ds5hm731	86	12	may	may	MD
cord-347986-ds5hm731	86	13	be	be	VB
cord-347986-ds5hm731	86	14	incompletely	incompletely	RB
cord-347986-ds5hm731	86	15	effective	effective	JJ
cord-347986-ds5hm731	86	16	against	against	IN
cord-347986-ds5hm731	86	17	these	these	DT
cord-347986-ds5hm731	86	18	multi	multi	JJ
cord-347986-ds5hm731	86	19	-	-	JJ
cord-347986-ds5hm731	86	20	drug	drug	JJ
cord-347986-ds5hm731	86	21	resistant	resistant	JJ
cord-347986-ds5hm731	86	22	strains	strain	NNS
cord-347986-ds5hm731	86	23	of	of	IN
cord-347986-ds5hm731	86	24	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	86	25	.	.	.
cord-347986-ds5hm731	87	1	A	a	DT
cord-347986-ds5hm731	87	2	Beijing	Beijing	NNP
cord-347986-ds5hm731	87	3	/	/	SYM
cord-347986-ds5hm731	87	4	W	w	NN
cord-347986-ds5hm731	87	5	genotype	genotype	NN
cord-347986-ds5hm731	87	6	strain	strain	NN
cord-347986-ds5hm731	87	7	,	,	,
cord-347986-ds5hm731	87	8	which	which	WDT
cord-347986-ds5hm731	87	9	has	have	VBZ
cord-347986-ds5hm731	87	10	developed	develop	VBN
cord-347986-ds5hm731	87	11	resistance	resistance	NN
cord-347986-ds5hm731	87	12	to	to	IN
cord-347986-ds5hm731	87	13	both	both	CC
cord-347986-ds5hm731	87	14	first	first	JJ
cord-347986-ds5hm731	87	15	and	and	CC
cord-347986-ds5hm731	87	16	second	second	JJ
cord-347986-ds5hm731	87	17	line	line	NN
cord-347986-ds5hm731	87	18	TB	TB	NNP
cord-347986-ds5hm731	87	19	drugs	drug	NNS
cord-347986-ds5hm731	87	20	,	,	,
cord-347986-ds5hm731	87	21	is	be	VBZ
cord-347986-ds5hm731	87	22	of	of	IN
cord-347986-ds5hm731	87	23	particular	particular	JJ
cord-347986-ds5hm731	87	24	concern	concern	NN
cord-347986-ds5hm731	87	25	.	.	.
cord-347986-ds5hm731	88	1	A	a	DT
cord-347986-ds5hm731	88	2	recent	recent	JJ
cord-347986-ds5hm731	88	3	review	review	NN
cord-347986-ds5hm731	88	4	combining	combine	VBG
cord-347986-ds5hm731	88	5	429,000	429,000	CD
cord-347986-ds5hm731	88	6	patients	patient	NNS
cord-347986-ds5hm731	88	7	in	in	IN
cord-347986-ds5hm731	88	8	49	49	CD
cord-347986-ds5hm731	88	9	studies	study	NNS
cord-347986-ds5hm731	88	10	from	from	IN
cord-347986-ds5hm731	88	11	35	35	CD
cord-347986-ds5hm731	88	12	countries	country	NNS
cord-347986-ds5hm731	88	13	has	have	VBZ
cord-347986-ds5hm731	88	14	found	find	VBN
cord-347986-ds5hm731	88	15	it	-PRON-	PRP
cord-347986-ds5hm731	88	16	to	to	TO
cord-347986-ds5hm731	88	17	be	be	VB
cord-347986-ds5hm731	88	18	epidemic	epidemic	NN
cord-347986-ds5hm731	88	19	in	in	IN
cord-347986-ds5hm731	88	20	Cuba	Cuba	NNP
cord-347986-ds5hm731	88	21	,	,	,
cord-347986-ds5hm731	88	22	the	the	DT
cord-347986-ds5hm731	88	23	former	former	JJ
cord-347986-ds5hm731	88	24	Soviet	Soviet	NNP
cord-347986-ds5hm731	88	25	Union	Union	NNP
cord-347986-ds5hm731	88	26	,	,	,
cord-347986-ds5hm731	88	27	and	and	CC
cord-347986-ds5hm731	88	28	South	South	NNP
cord-347986-ds5hm731	88	29	Africa	Africa	NNP
cord-347986-ds5hm731	88	30	,	,	,
cord-347986-ds5hm731	88	31	and	and	CC
cord-347986-ds5hm731	88	32	endemic	endemic	JJ
cord-347986-ds5hm731	88	33	in	in	IN
cord-347986-ds5hm731	88	34	East	East	NNP
cord-347986-ds5hm731	88	35	Asia	Asia	NNP
cord-347986-ds5hm731	88	36	[	[	-LRB-
cord-347986-ds5hm731	88	37	10	10	CD
cord-347986-ds5hm731	88	38	]	]	-RRB-
cord-347986-ds5hm731	88	39	.	.	.
cord-347986-ds5hm731	89	1	And	and	CC
cord-347986-ds5hm731	89	2	,	,	,
cord-347986-ds5hm731	89	3	estimates	estimate	VBZ
cord-347986-ds5hm731	89	4	place	place	VBP
cord-347986-ds5hm731	89	5	the	the	DT
cord-347986-ds5hm731	89	6	cost	cost	NN
cord-347986-ds5hm731	89	7	of	of	IN
cord-347986-ds5hm731	89	8	treating	treat	VBG
cord-347986-ds5hm731	89	9	MDR	MDR	NNP
cord-347986-ds5hm731	89	10	-	-	HYPH
cord-347986-ds5hm731	89	11	TB	TB	NNP
cord-347986-ds5hm731	89	12	at	at	IN
cord-347986-ds5hm731	89	13	$	$	$
cord-347986-ds5hm731	89	14	250,000-$750,000	250,000-$750,000	CD
cord-347986-ds5hm731	89	15	per	per	IN
cord-347986-ds5hm731	89	16	patient	patient	NN
cord-347986-ds5hm731	89	17	,	,	,
cord-347986-ds5hm731	89	18	because	because	IN
cord-347986-ds5hm731	89	19	of	of	IN
cord-347986-ds5hm731	89	20	the	the	DT
cord-347986-ds5hm731	89	21	extra	extra	JJ
cord-347986-ds5hm731	89	22	isolation	isolation	NN
cord-347986-ds5hm731	89	23	,	,	,
cord-347986-ds5hm731	89	24	monitoring	monitoring	NN
cord-347986-ds5hm731	89	25	,	,	,
cord-347986-ds5hm731	89	26	medical	medical	JJ
cord-347986-ds5hm731	89	27	supervision	supervision	NN
cord-347986-ds5hm731	89	28	,	,	,
cord-347986-ds5hm731	89	29	and	and	CC
cord-347986-ds5hm731	89	30	medication	medication	NN
cord-347986-ds5hm731	89	31	costs	cost	NNS
cord-347986-ds5hm731	89	32	required	require	VBN
cord-347986-ds5hm731	89	33	.	.	.
cord-347986-ds5hm731	90	1	Hence	hence	RB
cord-347986-ds5hm731	90	2	,	,	,
cord-347986-ds5hm731	90	3	there	there	EX
cord-347986-ds5hm731	90	4	has	have	VBZ
cord-347986-ds5hm731	90	5	been	be	VBN
cord-347986-ds5hm731	90	6	renewed	renew	VBN
cord-347986-ds5hm731	90	7	interest	interest	NN
cord-347986-ds5hm731	90	8	in	in	IN
cord-347986-ds5hm731	90	9	developing	develop	VBG
cord-347986-ds5hm731	90	10	new	new	JJ
cord-347986-ds5hm731	90	11	drugs	drug	NNS
cord-347986-ds5hm731	90	12	for	for	IN
cord-347986-ds5hm731	90	13	the	the	DT
cord-347986-ds5hm731	90	14	treatment	treatment	NN
cord-347986-ds5hm731	90	15	of	of	IN
cord-347986-ds5hm731	90	16	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	90	17	.	.	.
cord-347986-ds5hm731	91	1	Current	current	JJ
cord-347986-ds5hm731	91	2	goals	goal	NNS
cord-347986-ds5hm731	91	3	include	include	VBP
cord-347986-ds5hm731	91	4	compounds	compound	NNS
cord-347986-ds5hm731	91	5	which	which	WDT
cord-347986-ds5hm731	91	6	can	can	MD
cord-347986-ds5hm731	91	7	successfully	successfully	RB
cord-347986-ds5hm731	91	8	treat	treat	VB
cord-347986-ds5hm731	91	9	active	active	JJ
cord-347986-ds5hm731	91	10	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	91	11	in	in	IN
cord-347986-ds5hm731	91	12	a	a	DT
cord-347986-ds5hm731	91	13	shorter	short	JJR
cord-347986-ds5hm731	91	14	period	period	NN
cord-347986-ds5hm731	91	15	of	of	IN
cord-347986-ds5hm731	91	16	time	time	NN
cord-347986-ds5hm731	91	17	and/or	and/or	CC
cord-347986-ds5hm731	91	18	with	with	IN
cord-347986-ds5hm731	91	19	less	less	RBR
cord-347986-ds5hm731	91	20	frequent	frequent	JJ
cord-347986-ds5hm731	91	21	,	,	,
cord-347986-ds5hm731	91	22	intermittent	intermittent	JJ
cord-347986-ds5hm731	91	23	dosing	dosing	NN
cord-347986-ds5hm731	91	24	;	;	:
cord-347986-ds5hm731	91	25	compounds	compound	NNS
cord-347986-ds5hm731	91	26	to	to	TO
cord-347986-ds5hm731	91	27	deal	deal	VB
cord-347986-ds5hm731	91	28	with	with	IN
cord-347986-ds5hm731	91	29	MDR	MDR	NNP
cord-347986-ds5hm731	91	30	-	-	HYPH
cord-347986-ds5hm731	91	31	TB	TB	NNP
cord-347986-ds5hm731	91	32	;	;	:
cord-347986-ds5hm731	91	33	and	and	CC
cord-347986-ds5hm731	91	34	compounds	compound	NNS
cord-347986-ds5hm731	91	35	to	to	TO
cord-347986-ds5hm731	91	36	prevent	prevent	VB
cord-347986-ds5hm731	91	37	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	91	38	in	in	IN
cord-347986-ds5hm731	91	39	people	people	NNS
cord-347986-ds5hm731	91	40	at	at	IN
cord-347986-ds5hm731	91	41	risk	risk	NN
cord-347986-ds5hm731	91	42	of	of	IN
cord-347986-ds5hm731	91	43	MDR	MDR	NNP
cord-347986-ds5hm731	91	44	-	-	HYPH
cord-347986-ds5hm731	91	45	TB	TB	NNP
cord-347986-ds5hm731	91	46	.	.	.
cord-347986-ds5hm731	92	1	In	in	IN
cord-347986-ds5hm731	92	2	fact	fact	NN
cord-347986-ds5hm731	92	3	,	,	,
cord-347986-ds5hm731	92	4	a	a	DT
cord-347986-ds5hm731	92	5	recent	recent	JJ
cord-347986-ds5hm731	92	6	Cochrane	Cochrane	NNP
cord-347986-ds5hm731	92	7	review	review	NN
cord-347986-ds5hm731	92	8	covering	cover	VBG
cord-347986-ds5hm731	92	9	appropriate	appropriate	JJ
cord-347986-ds5hm731	92	10	studies	study	NNS
cord-347986-ds5hm731	92	11	to	to	TO
cord-347986-ds5hm731	92	12	address	address	VB
cord-347986-ds5hm731	92	13	the	the	DT
cord-347986-ds5hm731	92	14	problem	problem	NN
cord-347986-ds5hm731	92	15	of	of	IN
cord-347986-ds5hm731	92	16	treating	treat	VBG
cord-347986-ds5hm731	92	17	latent	latent	JJ
cord-347986-ds5hm731	92	18	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	92	19	infection	infection	NN
cord-347986-ds5hm731	92	20	in	in	IN
cord-347986-ds5hm731	92	21	people	people	NNS
cord-347986-ds5hm731	92	22	exposed	expose	VBN
cord-347986-ds5hm731	92	23	to	to	IN
cord-347986-ds5hm731	92	24	MDR	MDR	NNP
cord-347986-ds5hm731	92	25	-	-	HYPH
cord-347986-ds5hm731	92	26	TB	TB	NNP
cord-347986-ds5hm731	92	27	found	find	VBD
cord-347986-ds5hm731	92	28	there	there	EX
cord-347986-ds5hm731	92	29	were	be	VBD
cord-347986-ds5hm731	92	30	no	no	DT
cord-347986-ds5hm731	92	31	randomized	randomized	JJ
cord-347986-ds5hm731	92	32	controlled	control	VBN
cord-347986-ds5hm731	92	33	trials	trial	NNS
cord-347986-ds5hm731	92	34	in	in	IN
cord-347986-ds5hm731	92	35	the	the	DT
cord-347986-ds5hm731	92	36	database	database	NN
cord-347986-ds5hm731	92	37	that	that	WDT
cord-347986-ds5hm731	92	38	have	have	VBP
cord-347986-ds5hm731	92	39	assessed	assess	VBN
cord-347986-ds5hm731	92	40	the	the	DT
cord-347986-ds5hm731	92	41	effectiveness	effectiveness	NN
cord-347986-ds5hm731	92	42	of	of	IN
cord-347986-ds5hm731	92	43	treatment	treatment	NN
cord-347986-ds5hm731	92	44	[	[	-LRB-
cord-347986-ds5hm731	92	45	11	11	CD
cord-347986-ds5hm731	92	46	]	]	-RRB-
cord-347986-ds5hm731	92	47	.	.	.
cord-347986-ds5hm731	93	1	There	there	EX
cord-347986-ds5hm731	93	2	is	be	VBZ
cord-347986-ds5hm731	93	3	also	also	RB
cord-347986-ds5hm731	93	4	a	a	DT
cord-347986-ds5hm731	93	5	need	need	NN
cord-347986-ds5hm731	93	6	for	for	IN
cord-347986-ds5hm731	93	7	relatively	relatively	RB
cord-347986-ds5hm731	93	8	inexpensive	inexpensive	JJ
cord-347986-ds5hm731	93	9	drugs	drug	NNS
cord-347986-ds5hm731	93	10	and	and	CC
cord-347986-ds5hm731	93	11	medicines	medicine	NNS
cord-347986-ds5hm731	93	12	that	that	WDT
cord-347986-ds5hm731	93	13	can	can	MD
cord-347986-ds5hm731	93	14	be	be	VB
cord-347986-ds5hm731	93	15	given	give	VBN
cord-347986-ds5hm731	93	16	safely	safely	RB
cord-347986-ds5hm731	93	17	with	with	IN
cord-347986-ds5hm731	93	18	antiretroviral	antiretroviral	JJ
cord-347986-ds5hm731	93	19	(	(	-LRB-
cord-347986-ds5hm731	93	20	ARV	ARV	NNP
cord-347986-ds5hm731	93	21	)	)	-RRB-
cord-347986-ds5hm731	93	22	medications	medication	NNS
cord-347986-ds5hm731	93	23	for	for	IN
cord-347986-ds5hm731	93	24	HIV	HIV	NNP
cord-347986-ds5hm731	93	25	,	,	,
cord-347986-ds5hm731	93	26	because	because	IN
cord-347986-ds5hm731	93	27	of	of	IN
cord-347986-ds5hm731	93	28	the	the	DT
cord-347986-ds5hm731	93	29	growing	grow	VBG
cord-347986-ds5hm731	93	30	problem	problem	NN
cord-347986-ds5hm731	93	31	of	of	IN
cord-347986-ds5hm731	93	32	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	93	33	and	and	CC
cord-347986-ds5hm731	93	34	HIV	HIV	NNP
cord-347986-ds5hm731	93	35	co	co	NN
cord-347986-ds5hm731	93	36	-	-	NN
cord-347986-ds5hm731	93	37	infection	infection	NN
cord-347986-ds5hm731	93	38	.	.	.
cord-347986-ds5hm731	94	1	One	one	CD
cord-347986-ds5hm731	94	2	-	-	HYPH
cord-347986-ds5hm731	94	3	third	third	NN
cord-347986-ds5hm731	94	4	of	of	IN
cord-347986-ds5hm731	94	5	the	the	DT
cord-347986-ds5hm731	94	6	39	39	CD
cord-347986-ds5hm731	94	7	million	million	CD
cord-347986-ds5hm731	94	8	people	people	NNS
cord-347986-ds5hm731	94	9	infected	infect	VBN
cord-347986-ds5hm731	94	10	with	with	IN
cord-347986-ds5hm731	94	11	HIV	HIV	NNP
cord-347986-ds5hm731	94	12	,	,	,
cord-347986-ds5hm731	94	13	are	be	VBP
cord-347986-ds5hm731	94	14	also	also	RB
cord-347986-ds5hm731	94	15	infected	infect	VBN
cord-347986-ds5hm731	94	16	with	with	IN
cord-347986-ds5hm731	94	17	TB	TB	NNP
cord-347986-ds5hm731	94	18	,	,	,
cord-347986-ds5hm731	94	19	mostly	mostly	RB
cord-347986-ds5hm731	94	20	in	in	IN
cord-347986-ds5hm731	94	21	sub	sub	JJ
cord-347986-ds5hm731	94	22	-	-	JJ
cord-347986-ds5hm731	94	23	Saharan	saharan	JJ
cord-347986-ds5hm731	94	24	Africa	Africa	NNP
cord-347986-ds5hm731	94	25	.	.	.
cord-347986-ds5hm731	95	1	AIDS	AIDS	NNP
cord-347986-ds5hm731	95	2	patients	patient	NNS
cord-347986-ds5hm731	95	3	are	be	VBP
cord-347986-ds5hm731	95	4	particularly	particularly	RB
cord-347986-ds5hm731	95	5	vulnerable	vulnerable	JJ
cord-347986-ds5hm731	95	6	to	to	IN
cord-347986-ds5hm731	95	7	TB	TB	NNP
cord-347986-ds5hm731	95	8	because	because	IN
cord-347986-ds5hm731	95	9	of	of	IN
cord-347986-ds5hm731	95	10	their	-PRON-	PRP$
cord-347986-ds5hm731	95	11	weakened	weakened	JJ
cord-347986-ds5hm731	95	12	immune	immune	JJ
cord-347986-ds5hm731	95	13	systems	system	NNS
cord-347986-ds5hm731	95	14	,	,	,
cord-347986-ds5hm731	95	15	which	which	WDT
cord-347986-ds5hm731	95	16	makes	make	VBZ
cord-347986-ds5hm731	95	17	them	-PRON-	PRP
cord-347986-ds5hm731	95	18	more	more	RBR
cord-347986-ds5hm731	95	19	susceptible	susceptible	JJ
cord-347986-ds5hm731	95	20	to	to	IN
cord-347986-ds5hm731	95	21	contracting	contract	VBG
cord-347986-ds5hm731	95	22	TB	TB	NNP
cord-347986-ds5hm731	95	23	or	or	CC
cord-347986-ds5hm731	95	24	allows	allow	VBZ
cord-347986-ds5hm731	95	25	previous	previous	JJ
cord-347986-ds5hm731	95	26	infection	infection	NN
cord-347986-ds5hm731	95	27	with	with	IN
cord-347986-ds5hm731	95	28	TB	TB	NNP
cord-347986-ds5hm731	95	29	that	that	WDT
cord-347986-ds5hm731	95	30	has	have	VBZ
cord-347986-ds5hm731	95	31	been	be	VBN
cord-347986-ds5hm731	95	32	suppressed	suppress	VBN
cord-347986-ds5hm731	95	33	and	and	CC
cord-347986-ds5hm731	95	34	contained	contain	VBN
cord-347986-ds5hm731	95	35	by	by	IN
cord-347986-ds5hm731	95	36	the	the	DT
cord-347986-ds5hm731	95	37	immune	immune	JJ
cord-347986-ds5hm731	95	38	system	system	NN
cord-347986-ds5hm731	95	39	to	to	TO
cord-347986-ds5hm731	95	40	become	become	VB
cord-347986-ds5hm731	95	41	active	active	JJ
cord-347986-ds5hm731	95	42	.	.	.
cord-347986-ds5hm731	96	1	TB	TB	NNP
cord-347986-ds5hm731	96	2	is	be	VBZ
cord-347986-ds5hm731	96	3	a	a	DT
cord-347986-ds5hm731	96	4	leading	leading	JJ
cord-347986-ds5hm731	96	5	cause	cause	NN
cord-347986-ds5hm731	96	6	of	of	IN
cord-347986-ds5hm731	96	7	death	death	NN
cord-347986-ds5hm731	96	8	for	for	IN
cord-347986-ds5hm731	96	9	people	people	NNS
cord-347986-ds5hm731	96	10	living	live	VBG
cord-347986-ds5hm731	96	11	with	with	IN
cord-347986-ds5hm731	96	12	HIV	HIV	NNP
cord-347986-ds5hm731	96	13	/	/	SYM
cord-347986-ds5hm731	96	14	AIDS	AIDS	NNP
cord-347986-ds5hm731	96	15	,	,	,
cord-347986-ds5hm731	96	16	but	but	CC
cord-347986-ds5hm731	96	17	treating	treat	VBG
cord-347986-ds5hm731	96	18	both	both	DT
cord-347986-ds5hm731	96	19	diseases	disease	NNS
cord-347986-ds5hm731	96	20	simultaneously	simultaneously	RB
cord-347986-ds5hm731	96	21	is	be	VBZ
cord-347986-ds5hm731	96	22	difficult	difficult	JJ
cord-347986-ds5hm731	96	23	.	.	.
cord-347986-ds5hm731	97	1	Many	many	JJ
cord-347986-ds5hm731	97	2	of	of	IN
cord-347986-ds5hm731	97	3	the	the	DT
cord-347986-ds5hm731	97	4	first	first	JJ
cord-347986-ds5hm731	97	5	-	-	HYPH
cord-347986-ds5hm731	97	6	line	line	NN
cord-347986-ds5hm731	97	7	TB	TB	NNP
cord-347986-ds5hm731	97	8	medications	medication	NNS
cord-347986-ds5hm731	97	9	like	like	IN
cord-347986-ds5hm731	97	10	rifampin	rifampin	NN
cord-347986-ds5hm731	97	11	cause	cause	VBP
cord-347986-ds5hm731	97	12	adverse	adverse	JJ
cord-347986-ds5hm731	97	13	drug	drug	NN
cord-347986-ds5hm731	97	14	-	-	HYPH
cord-347986-ds5hm731	97	15	drug	drug	NN
cord-347986-ds5hm731	97	16	reactions	reaction	NNS
cord-347986-ds5hm731	97	17	if	if	IN
cord-347986-ds5hm731	97	18	given	give	VBN
cord-347986-ds5hm731	97	19	with	with	IN
cord-347986-ds5hm731	97	20	ARV	ARV	NNP
cord-347986-ds5hm731	97	21	medications	medication	NNS
cord-347986-ds5hm731	97	22	,	,	,
cord-347986-ds5hm731	97	23	because	because	IN
cord-347986-ds5hm731	97	24	both	both	DT
cord-347986-ds5hm731	97	25	utilize	utilize	VB
cord-347986-ds5hm731	97	26	the	the	DT
cord-347986-ds5hm731	97	27	same	same	JJ
cord-347986-ds5hm731	97	28	hepatic	hepatic	JJ
cord-347986-ds5hm731	97	29	metabolic	metabolic	JJ
cord-347986-ds5hm731	97	30	pathway	pathway	NN
cord-347986-ds5hm731	97	31	.	.	.
cord-347986-ds5hm731	98	1	Although	although	IN
cord-347986-ds5hm731	98	2	more	more	JJR
cord-347986-ds5hm731	98	3	than	than	IN
cord-347986-ds5hm731	98	4	40	40	CD
cord-347986-ds5hm731	98	5	years	year	NNS
cord-347986-ds5hm731	98	6	has	have	VBZ
cord-347986-ds5hm731	98	7	passed	pass	VBN
cord-347986-ds5hm731	98	8	since	since	IN
cord-347986-ds5hm731	98	9	the	the	DT
cord-347986-ds5hm731	98	10	last	last	JJ
cord-347986-ds5hm731	98	11	novel	novel	JJ
cord-347986-ds5hm731	98	12	TB	TB	NNP
cord-347986-ds5hm731	98	13	drug	drug	NN
cord-347986-ds5hm731	98	14	,	,	,
cord-347986-ds5hm731	98	15	rifampin	rifampin	NN
cord-347986-ds5hm731	98	16	,	,	,
cord-347986-ds5hm731	98	17	was	be	VBD
cord-347986-ds5hm731	98	18	discovered	discover	VBN
cord-347986-ds5hm731	98	19	,	,	,
cord-347986-ds5hm731	98	20	there	there	EX
cord-347986-ds5hm731	98	21	are	be	VBP
cord-347986-ds5hm731	98	22	a	a	DT
cord-347986-ds5hm731	98	23	large	large	JJ
cord-347986-ds5hm731	98	24	number	number	NN
cord-347986-ds5hm731	98	25	of	of	IN
cord-347986-ds5hm731	98	26	new	new	JJ
cord-347986-ds5hm731	98	27	drugs	drug	NNS
cord-347986-ds5hm731	98	28	now	now	RB
cord-347986-ds5hm731	98	29	in	in	IN
cord-347986-ds5hm731	98	30	the	the	DT
cord-347986-ds5hm731	98	31	pipeline	pipeline	NN
cord-347986-ds5hm731	98	32	.	.	.
cord-347986-ds5hm731	99	1	Many	many	JJ
cord-347986-ds5hm731	99	2	are	be	VBP
cord-347986-ds5hm731	99	3	still	still	RB
cord-347986-ds5hm731	99	4	in	in	IN
cord-347986-ds5hm731	99	5	early	early	JJ
cord-347986-ds5hm731	99	6	preclinical	preclinical	JJ
cord-347986-ds5hm731	99	7	stages	stage	NNS
cord-347986-ds5hm731	99	8	,	,	,
cord-347986-ds5hm731	99	9	but	but	CC
cord-347986-ds5hm731	99	10	this	this	DT
cord-347986-ds5hm731	99	11	discussion	discussion	NN
cord-347986-ds5hm731	99	12	will	will	MD
cord-347986-ds5hm731	99	13	focus	focus	VB
cord-347986-ds5hm731	99	14	on	on	IN
cord-347986-ds5hm731	99	15	those	those	DT
cord-347986-ds5hm731	99	16	already	already	RB
cord-347986-ds5hm731	99	17	in	in	IN
cord-347986-ds5hm731	99	18	clinical	clinical	JJ
cord-347986-ds5hm731	99	19	human	human	JJ
cord-347986-ds5hm731	99	20	trials	trial	NNS
cord-347986-ds5hm731	99	21	and	and	CC
cord-347986-ds5hm731	99	22	of	of	IN
cord-347986-ds5hm731	99	23	particular	particular	JJ
cord-347986-ds5hm731	99	24	relevance	relevance	NN
cord-347986-ds5hm731	99	25	to	to	IN
cord-347986-ds5hm731	99	26	the	the	DT
cord-347986-ds5hm731	99	27	developing	develop	VBG
cord-347986-ds5hm731	99	28	world	world	NN
cord-347986-ds5hm731	99	29	.	.	.
cord-347986-ds5hm731	100	1	Moxifloxacin	Moxifloxacin	NNP
cord-347986-ds5hm731	100	2	,	,	,
cord-347986-ds5hm731	100	3	4	4	CD
cord-347986-ds5hm731	100	4	,	,	,
cord-347986-ds5hm731	100	5	is	be	VBZ
cord-347986-ds5hm731	100	6	a	a	DT
cord-347986-ds5hm731	100	7	methoxyfluoroquinolone	methoxyfluoroquinolone	NN
cord-347986-ds5hm731	100	8	which	which	WDT
cord-347986-ds5hm731	100	9	is	be	VBZ
cord-347986-ds5hm731	100	10	already	already	RB
cord-347986-ds5hm731	100	11	available	available	JJ
cord-347986-ds5hm731	100	12	and	and	CC
cord-347986-ds5hm731	100	13	approved	approve	VBN
cord-347986-ds5hm731	100	14	for	for	IN
cord-347986-ds5hm731	100	15	the	the	DT
cord-347986-ds5hm731	100	16	treatment	treatment	NN
cord-347986-ds5hm731	100	17	of	of	IN
cord-347986-ds5hm731	100	18	acute	acute	JJ
cord-347986-ds5hm731	100	19	respiratory	respiratory	JJ
cord-347986-ds5hm731	100	20	infections	infection	NNS
cord-347986-ds5hm731	100	21	such	such	JJ
cord-347986-ds5hm731	100	22	as	as	IN
cord-347986-ds5hm731	100	23	community	community	NN
cord-347986-ds5hm731	100	24	-	-	HYPH
cord-347986-ds5hm731	100	25	acquired	acquire	VBN
cord-347986-ds5hm731	100	26	pneumonia	pneumonia	NN
cord-347986-ds5hm731	100	27	,	,	,
cord-347986-ds5hm731	100	28	intra	intra	JJ
cord-347986-ds5hm731	100	29	-	-	JJ
cord-347986-ds5hm731	100	30	abdominal	abdominal	JJ
cord-347986-ds5hm731	100	31	infections	infection	NNS
cord-347986-ds5hm731	100	32	,	,	,
cord-347986-ds5hm731	100	33	acute	acute	JJ
cord-347986-ds5hm731	100	34	sinusitis	sinusitis	NN
cord-347986-ds5hm731	100	35	,	,	,
cord-347986-ds5hm731	100	36	and	and	CC
cord-347986-ds5hm731	100	37	skin	skin	NN
cord-347986-ds5hm731	100	38	infections	infection	NNS
cord-347986-ds5hm731	100	39	.	.	.
cord-347986-ds5hm731	101	1	It	-PRON-	PRP
cord-347986-ds5hm731	101	2	is	be	VBZ
cord-347986-ds5hm731	101	3	an	an	DT
cord-347986-ds5hm731	101	4	inhibitor	inhibitor	NN
cord-347986-ds5hm731	101	5	of	of	IN
cord-347986-ds5hm731	101	6	DNA	dna	NN
cord-347986-ds5hm731	101	7	gyrase	gyrase	NN
cord-347986-ds5hm731	101	8	,	,	,
cord-347986-ds5hm731	101	9	which	which	WDT
cord-347986-ds5hm731	101	10	is	be	VBZ
cord-347986-ds5hm731	101	11	an	an	DT
cord-347986-ds5hm731	101	12	enzyme	enzyme	NN
cord-347986-ds5hm731	101	13	important	important	JJ
cord-347986-ds5hm731	101	14	in	in	IN
cord-347986-ds5hm731	101	15	bacterial	bacterial	JJ
cord-347986-ds5hm731	101	16	growth	growth	NN
cord-347986-ds5hm731	101	17	and	and	CC
cord-347986-ds5hm731	101	18	replication	replication	NN
cord-347986-ds5hm731	101	19	.	.	.
cord-347986-ds5hm731	102	1	It	-PRON-	PRP
cord-347986-ds5hm731	102	2	has	have	VBZ
cord-347986-ds5hm731	102	3	an	an	DT
cord-347986-ds5hm731	102	4	excellent	excellent	JJ
cord-347986-ds5hm731	102	5	safety	safety	NN
cord-347986-ds5hm731	102	6	profile	profile	NN
cord-347986-ds5hm731	102	7	and	and	CC
cord-347986-ds5hm731	102	8	has	have	VBZ
cord-347986-ds5hm731	102	9	already	already	RB
cord-347986-ds5hm731	102	10	been	be	VBN
cord-347986-ds5hm731	102	11	used	use	VBN
cord-347986-ds5hm731	102	12	by	by	IN
cord-347986-ds5hm731	102	13	42	42	CD
cord-347986-ds5hm731	102	14	million	million	CD
cord-347986-ds5hm731	102	15	patients	patient	NNS
cord-347986-ds5hm731	102	16	worldwide	worldwide	RB
cord-347986-ds5hm731	102	17	.	.	.
cord-347986-ds5hm731	103	1	However	however	RB
cord-347986-ds5hm731	103	2	,	,	,
cord-347986-ds5hm731	103	3	the	the	DT
cord-347986-ds5hm731	103	4	drug	drug	NN
cord-347986-ds5hm731	103	5	has	have	VBZ
cord-347986-ds5hm731	103	6	not	not	RB
cord-347986-ds5hm731	103	7	been	be	VBN
cord-347986-ds5hm731	103	8	adequately	adequately	RB
cord-347986-ds5hm731	103	9	evaluated	evaluate	VBN
cord-347986-ds5hm731	103	10	in	in	IN
cord-347986-ds5hm731	103	11	children	child	NNS
cord-347986-ds5hm731	103	12	and	and	CC
cord-347986-ds5hm731	103	13	pregnant	pregnant	JJ
cord-347986-ds5hm731	103	14	or	or	CC
cord-347986-ds5hm731	103	15	lactating	lactate	VBG
cord-347986-ds5hm731	103	16	women	woman	NNS
cord-347986-ds5hm731	103	17	.	.	.
cord-347986-ds5hm731	104	1	In	in	IN
cord-347986-ds5hm731	104	2	vitro	vitro	FW
cord-347986-ds5hm731	104	3	and	and	CC
cord-347986-ds5hm731	104	4	in	in	IN
cord-347986-ds5hm731	104	5	vivo	vivo	NNP
cord-347986-ds5hm731	104	6	studies	study	NNS
cord-347986-ds5hm731	104	7	have	have	VBP
cord-347986-ds5hm731	104	8	demonstrated	demonstrate	VBN
cord-347986-ds5hm731	104	9	good	good	JJ
cord-347986-ds5hm731	104	10	activity	activity	NN
cord-347986-ds5hm731	104	11	against	against	IN
cord-347986-ds5hm731	104	12	M.	M.	NNP
cord-347986-ds5hm731	104	13	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	104	14	[	[	-LRB-
cord-347986-ds5hm731	104	15	12	12	CD
cord-347986-ds5hm731	104	16	,	,	,
cord-347986-ds5hm731	104	17	13	13	CD
cord-347986-ds5hm731	104	18	]	]	-RRB-
cord-347986-ds5hm731	104	19	.	.	.
cord-347986-ds5hm731	105	1	Moxifloxacin	Moxifloxacin	NNP
cord-347986-ds5hm731	105	2	has	have	VBZ
cord-347986-ds5hm731	105	3	a	a	DT
cord-347986-ds5hm731	105	4	minimum	minimum	JJ
cord-347986-ds5hm731	105	5	inhibitory	inhibitory	JJ
cord-347986-ds5hm731	105	6	concentration	concentration	NN
cord-347986-ds5hm731	105	7	(	(	-LRB-
cord-347986-ds5hm731	105	8	MIC	MIC	NNP
cord-347986-ds5hm731	105	9	)	)	-RRB-
cord-347986-ds5hm731	105	10	against	against	IN
cord-347986-ds5hm731	105	11	M.	M.	NNP
cord-347986-ds5hm731	105	12	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	105	13	fourfold	fourfold	NN
cord-347986-ds5hm731	105	14	lower	lower	RBR
cord-347986-ds5hm731	105	15	than	than	IN
cord-347986-ds5hm731	105	16	levofloxacin	levofloxacin	NNS
cord-347986-ds5hm731	105	17	,	,	,
cord-347986-ds5hm731	105	18	a	a	DT
cord-347986-ds5hm731	105	19	second	second	JJ
cord-347986-ds5hm731	105	20	-	-	HYPH
cord-347986-ds5hm731	105	21	generation	generation	NN
cord-347986-ds5hm731	105	22	fluoroquinolone	fluoroquinolone	NN
cord-347986-ds5hm731	105	23	already	already	RB
cord-347986-ds5hm731	105	24	in	in	IN
cord-347986-ds5hm731	105	25	use	use	NN
cord-347986-ds5hm731	105	26	for	for	IN
cord-347986-ds5hm731	105	27	MDR	MDR	NNP
cord-347986-ds5hm731	105	28	-	-	HYPH
cord-347986-ds5hm731	105	29	TB	TB	NNP
cord-347986-ds5hm731	105	30	.	.	.
cord-347986-ds5hm731	106	1	(	(	-LRB-
cord-347986-ds5hm731	106	2	Older	old	JJR
cord-347986-ds5hm731	106	3	fluoroquinolones	fluoroquinolone	NNS
cord-347986-ds5hm731	106	4	like	like	IN
cord-347986-ds5hm731	106	5	levofloxacin	levofloxacin	NNS
cord-347986-ds5hm731	106	6	and	and	CC
cord-347986-ds5hm731	106	7	ofloxacin	ofloxacin	NNS
cord-347986-ds5hm731	106	8	are	be	VBP
cord-347986-ds5hm731	106	9	only	only	RB
cord-347986-ds5hm731	106	10	used	use	VBN
cord-347986-ds5hm731	106	11	for	for	IN
cord-347986-ds5hm731	106	12	MDR	MDR	NNP
cord-347986-ds5hm731	106	13	-	-	HYPH
cord-347986-ds5hm731	106	14	TB	TB	NNP
cord-347986-ds5hm731	106	15	treatment	treatment	NN
cord-347986-ds5hm731	106	16	because	because	IN
cord-347986-ds5hm731	106	17	of	of	IN
cord-347986-ds5hm731	106	18	initial	initial	JJ
cord-347986-ds5hm731	106	19	studies	study	NNS
cord-347986-ds5hm731	106	20	showing	show	VBG
cord-347986-ds5hm731	106	21	lack	lack	NN
cord-347986-ds5hm731	106	22	of	of	IN
cord-347986-ds5hm731	106	23	superiority	superiority	NN
cord-347986-ds5hm731	106	24	to	to	IN
cord-347986-ds5hm731	106	25	existing	exist	VBG
cord-347986-ds5hm731	106	26	first	first	JJ
cord-347986-ds5hm731	106	27	-	-	HYPH
cord-347986-ds5hm731	106	28	line	line	NN
cord-347986-ds5hm731	106	29	drugs	drug	NNS
cord-347986-ds5hm731	106	30	.	.	.
cord-347986-ds5hm731	106	31	)	)	-RRB-
cord-347986-ds5hm731	107	1	It	-PRON-	PRP
cord-347986-ds5hm731	107	2	also	also	RB
cord-347986-ds5hm731	107	3	has	have	VBZ
cord-347986-ds5hm731	107	4	a	a	DT
cord-347986-ds5hm731	107	5	long	long	JJ
cord-347986-ds5hm731	107	6	half	half	JJ
cord-347986-ds5hm731	107	7	-	-	HYPH
cord-347986-ds5hm731	107	8	life	life	NN
cord-347986-ds5hm731	107	9	and	and	CC
cord-347986-ds5hm731	107	10	high	high	JJ
cord-347986-ds5hm731	107	11	area	area	NN
cord-347986-ds5hm731	107	12	under	under	IN
cord-347986-ds5hm731	107	13	the	the	DT
cord-347986-ds5hm731	107	14	curve	curve	NN
cord-347986-ds5hm731	107	15	concentration	concentration	NN
cord-347986-ds5hm731	107	16	.	.	.
cord-347986-ds5hm731	108	1	A	a	DT
cord-347986-ds5hm731	108	2	murine	murine	JJ
cord-347986-ds5hm731	108	3	model	model	NN
cord-347986-ds5hm731	108	4	study	study	NN
cord-347986-ds5hm731	108	5	found	find	VBD
cord-347986-ds5hm731	108	6	that	that	IN
cord-347986-ds5hm731	108	7	substituting	substitute	VBG
cord-347986-ds5hm731	108	8	moxifloxacin	moxifloxacin	NNS
cord-347986-ds5hm731	108	9	for	for	IN
cord-347986-ds5hm731	108	10	isoniazid	isoniazid	NN
cord-347986-ds5hm731	108	11	decreased	decrease	VBD
cord-347986-ds5hm731	108	12	the	the	DT
cord-347986-ds5hm731	108	13	overall	overall	JJ
cord-347986-ds5hm731	108	14	time	time	NN
cord-347986-ds5hm731	108	15	necessary	necessary	JJ
cord-347986-ds5hm731	108	16	for	for	IN
cord-347986-ds5hm731	108	17	TB	TB	NNP
cord-347986-ds5hm731	108	18	eradication	eradication	NN
cord-347986-ds5hm731	108	19	by	by	IN
cord-347986-ds5hm731	108	20	two	two	CD
cord-347986-ds5hm731	108	21	months	month	NNS
cord-347986-ds5hm731	108	22	.	.	.
cord-347986-ds5hm731	109	1	Moxifloxacin	Moxifloxacin	NNP
cord-347986-ds5hm731	109	2	is	be	VBZ
cord-347986-ds5hm731	109	3	currently	currently	RB
cord-347986-ds5hm731	109	4	in	in	IN
cord-347986-ds5hm731	109	5	four	four	CD
cord-347986-ds5hm731	109	6	different	different	JJ
cord-347986-ds5hm731	109	7	Phase	Phase	NNP
cord-347986-ds5hm731	109	8	II	ii	CD
cord-347986-ds5hm731	109	9	trials	trial	NNS
cord-347986-ds5hm731	109	10	in	in	IN
cord-347986-ds5hm731	109	11	eight	eight	CD
cord-347986-ds5hm731	109	12	countries	country	NNS
cord-347986-ds5hm731	109	13	-Brazil	-Brazil	NNP
cord-347986-ds5hm731	109	14	,	,	,
cord-347986-ds5hm731	109	15	Canada	Canada	NNP
cord-347986-ds5hm731	109	16	,	,	,
cord-347986-ds5hm731	109	17	South	South	NNP
cord-347986-ds5hm731	109	18	Africa	Africa	NNP
cord-347986-ds5hm731	109	19	,	,	,
cord-347986-ds5hm731	109	20	Spain	Spain	NNP
cord-347986-ds5hm731	109	21	,	,	,
cord-347986-ds5hm731	109	22	Tanzania	Tanzania	NNP
cord-347986-ds5hm731	109	23	,	,	,
cord-347986-ds5hm731	109	24	Uganda	Uganda	NNP
cord-347986-ds5hm731	109	25	,	,	,
cord-347986-ds5hm731	109	26	the	the	DT
cord-347986-ds5hm731	109	27	United	United	NNP
cord-347986-ds5hm731	109	28	States	States	NNP
cord-347986-ds5hm731	109	29	,	,	,
cord-347986-ds5hm731	109	30	and	and	CC
cord-347986-ds5hm731	109	31	Zambia	Zambia	NNP
cord-347986-ds5hm731	109	32	,	,	,
cord-347986-ds5hm731	109	33	with	with	IN
cord-347986-ds5hm731	109	34	a	a	DT
cord-347986-ds5hm731	109	35	goal	goal	NN
cord-347986-ds5hm731	109	36	of	of	IN
cord-347986-ds5hm731	109	37	demonstrating	demonstrate	VBG
cord-347986-ds5hm731	109	38	efficacy	efficacy	NN
cord-347986-ds5hm731	109	39	as	as	IN
cord-347986-ds5hm731	109	40	a	a	DT
cord-347986-ds5hm731	109	41	first	first	JJ
cord-347986-ds5hm731	109	42	-	-	HYPH
cord-347986-ds5hm731	109	43	line	line	NN
cord-347986-ds5hm731	109	44	component	component	NN
cord-347986-ds5hm731	109	45	of	of	IN
cord-347986-ds5hm731	109	46	a	a	DT
cord-347986-ds5hm731	109	47	shorter	short	JJR
cord-347986-ds5hm731	109	48	,	,	,
cord-347986-ds5hm731	109	49	standardized	standardized	JJ
cord-347986-ds5hm731	109	50	TB	TB	NNP
cord-347986-ds5hm731	109	51	treatment	treatment	NN
cord-347986-ds5hm731	109	52	regimen	regimen	NN
cord-347986-ds5hm731	109	53	.	.	.
cord-347986-ds5hm731	110	1	The	the	DT
cord-347986-ds5hm731	110	2	hypothesis	hypothesis	NN
cord-347986-ds5hm731	110	3	is	be	VBZ
cord-347986-ds5hm731	110	4	that	that	IN
cord-347986-ds5hm731	110	5	moxifloxacin	moxifloxacin	VBZ
cord-347986-ds5hm731	110	6	substitution	substitution	NN
cord-347986-ds5hm731	110	7	for	for	IN
cord-347986-ds5hm731	110	8	isoniazid	isoniazid	NNP
cord-347986-ds5hm731	110	9	or	or	CC
cord-347986-ds5hm731	110	10	ethambutol	ethambutol	NN
cord-347986-ds5hm731	110	11	in	in	IN
cord-347986-ds5hm731	110	12	the	the	DT
cord-347986-ds5hm731	110	13	usual	usual	JJ
cord-347986-ds5hm731	110	14	four	four	CD
cord-347986-ds5hm731	110	15	drug	drug	NN
cord-347986-ds5hm731	110	16	standard	standard	JJ
cord-347986-ds5hm731	110	17	regimen	regimen	NN
cord-347986-ds5hm731	110	18	(	(	-LRB-
cord-347986-ds5hm731	110	19	isoniazid	isoniazid	FW
cord-347986-ds5hm731	110	20	,	,	,
cord-347986-ds5hm731	110	21	rifampin	rifampin	NN
cord-347986-ds5hm731	110	22	,	,	,
cord-347986-ds5hm731	110	23	ethambutol	ethambutol	NNP
cord-347986-ds5hm731	110	24	,	,	,
cord-347986-ds5hm731	110	25	and	and	CC
cord-347986-ds5hm731	110	26	pyrazinamide	pyrazinamide	NN
cord-347986-ds5hm731	110	27	)	)	-RRB-
cord-347986-ds5hm731	110	28	during	during	IN
cord-347986-ds5hm731	110	29	the	the	DT
cord-347986-ds5hm731	110	30	first	first	JJ
cord-347986-ds5hm731	110	31	two	two	CD
cord-347986-ds5hm731	110	32	months	month	NNS
cord-347986-ds5hm731	110	33	of	of	IN
cord-347986-ds5hm731	110	34	treatment	treatment	NN
cord-347986-ds5hm731	110	35	will	will	MD
cord-347986-ds5hm731	110	36	significantly	significantly	RB
cord-347986-ds5hm731	110	37	increase	increase	VB
cord-347986-ds5hm731	110	38	the	the	DT
cord-347986-ds5hm731	110	39	proportion	proportion	NN
cord-347986-ds5hm731	110	40	of	of	IN
cord-347986-ds5hm731	110	41	patients	patient	NNS
cord-347986-ds5hm731	110	42	with	with	IN
cord-347986-ds5hm731	110	43	culture	culture	NN
cord-347986-ds5hm731	110	44	-	-	HYPH
cord-347986-ds5hm731	110	45	negative	negative	JJ
cord-347986-ds5hm731	110	46	sputum	sputum	NN
cord-347986-ds5hm731	110	47	at	at	IN
cord-347986-ds5hm731	110	48	8	8	CD
cord-347986-ds5hm731	110	49	weeks	week	NNS
cord-347986-ds5hm731	110	50	,	,	,
cord-347986-ds5hm731	110	51	compared	compare	VBN
cord-347986-ds5hm731	110	52	with	with	IN
cord-347986-ds5hm731	110	53	the	the	DT
cord-347986-ds5hm731	110	54	standard	standard	JJ
cord-347986-ds5hm731	110	55	regimen	regimen	NN
cord-347986-ds5hm731	110	56	.	.	.
cord-347986-ds5hm731	111	1	Phase	phase	NN
cord-347986-ds5hm731	111	2	II	ii	CD
cord-347986-ds5hm731	111	3	trials	trial	NNS
cord-347986-ds5hm731	111	4	,	,	,
cord-347986-ds5hm731	111	5	are	be	VBP
cord-347986-ds5hm731	111	6	expected	expect	VBN
cord-347986-ds5hm731	111	7	to	to	TO
cord-347986-ds5hm731	111	8	complete	complete	VB
cord-347986-ds5hm731	111	9	in	in	IN
cord-347986-ds5hm731	111	10	2007	2007	CD
cord-347986-ds5hm731	111	11	,	,	,
cord-347986-ds5hm731	111	12	with	with	IN
cord-347986-ds5hm731	111	13	Phase	Phase	NNP
cord-347986-ds5hm731	111	14	III	iii	CD
cord-347986-ds5hm731	111	15	trials	trial	NNS
cord-347986-ds5hm731	111	16	to	to	TO
cord-347986-ds5hm731	111	17	follow	follow	VB
cord-347986-ds5hm731	111	18	.	.	.
cord-347986-ds5hm731	112	1	Moxifloxacin	Moxifloxacin	NNP
cord-347986-ds5hm731	112	2	metabolism	metabolism	NN
cord-347986-ds5hm731	112	3	also	also	RB
cord-347986-ds5hm731	112	4	does	do	VBZ
cord-347986-ds5hm731	112	5	not	not	RB
cord-347986-ds5hm731	112	6	utilize	utilize	VB
cord-347986-ds5hm731	112	7	the	the	DT
cord-347986-ds5hm731	112	8	hepatic	hepatic	JJ
cord-347986-ds5hm731	112	9	cytochrome	cytochrome	NN
cord-347986-ds5hm731	112	10	P-450	p-450	NN
cord-347986-ds5hm731	112	11	system	system	NN
cord-347986-ds5hm731	112	12	,	,	,
cord-347986-ds5hm731	112	13	and	and	CC
cord-347986-ds5hm731	112	14	does	do	VBZ
cord-347986-ds5hm731	112	15	not	not	RB
cord-347986-ds5hm731	112	16	lead	lead	VB
cord-347986-ds5hm731	112	17	to	to	IN
cord-347986-ds5hm731	112	18	adverse	adverse	JJ
cord-347986-ds5hm731	112	19	reactions	reaction	NNS
cord-347986-ds5hm731	112	20	when	when	WRB
cord-347986-ds5hm731	112	21	taken	take	VBN
cord-347986-ds5hm731	112	22	alongside	alongside	IN
cord-347986-ds5hm731	112	23	ARVs	arv	NNS
cord-347986-ds5hm731	112	24	.	.	.
cord-347986-ds5hm731	113	1	However	however	RB
cord-347986-ds5hm731	113	2	,	,	,
cord-347986-ds5hm731	113	3	one	one	CD
cord-347986-ds5hm731	113	4	recent	recent	JJ
cord-347986-ds5hm731	113	5	study	study	NN
cord-347986-ds5hm731	113	6	in	in	IN
cord-347986-ds5hm731	113	7	Italy	Italy	NNP
cord-347986-ds5hm731	113	8	found	find	VBD
cord-347986-ds5hm731	113	9	that	that	IN
cord-347986-ds5hm731	113	10	12/38	12/38	CD
cord-347986-ds5hm731	113	11	patients	patient	NNS
cord-347986-ds5hm731	113	12	treated	treat	VBN
cord-347986-ds5hm731	113	13	with	with	IN
cord-347986-ds5hm731	113	14	long	long	JJ
cord-347986-ds5hm731	113	15	-	-	HYPH
cord-347986-ds5hm731	113	16	term	term	NN
cord-347986-ds5hm731	113	17	moxifloxacin	moxifloxacin	NNS
cord-347986-ds5hm731	113	18	for	for	IN
cord-347986-ds5hm731	113	19	TB	TB	NNP
cord-347986-ds5hm731	113	20	developed	develop	VBD
cord-347986-ds5hm731	113	21	adverse	adverse	JJ
cord-347986-ds5hm731	113	22	reactions	reaction	NNS
cord-347986-ds5hm731	113	23	.	.	.
cord-347986-ds5hm731	114	1	None	none	NN
cord-347986-ds5hm731	114	2	of	of	IN
cord-347986-ds5hm731	114	3	the	the	DT
cord-347986-ds5hm731	114	4	reactions	reaction	NNS
cord-347986-ds5hm731	114	5	was	be	VBD
cord-347986-ds5hm731	114	6	irreversible	irreversible	JJ
cord-347986-ds5hm731	114	7	or	or	CC
cord-347986-ds5hm731	114	8	fatal	fatal	JJ
cord-347986-ds5hm731	114	9	,	,	,
cord-347986-ds5hm731	114	10	and	and	CC
cord-347986-ds5hm731	114	11	moxifloxacin	moxifloxacin	NNS
cord-347986-ds5hm731	114	12	was	be	VBD
cord-347986-ds5hm731	114	13	felt	feel	VBN
cord-347986-ds5hm731	114	14	to	to	TO
cord-347986-ds5hm731	114	15	be	be	VB
cord-347986-ds5hm731	114	16	safe	safe	JJ
cord-347986-ds5hm731	114	17	and	and	CC
cord-347986-ds5hm731	114	18	result	result	VB
cord-347986-ds5hm731	114	19	in	in	IN
cord-347986-ds5hm731	114	20	treatment	treatment	NN
cord-347986-ds5hm731	114	21	success	success	NN
cord-347986-ds5hm731	114	22	in	in	IN
cord-347986-ds5hm731	114	23	31/38	31/38	CD
cord-347986-ds5hm731	114	24	patients	patient	NNS
cord-347986-ds5hm731	114	25	.	.	.
cord-347986-ds5hm731	115	1	The	the	DT
cord-347986-ds5hm731	115	2	success	success	NN
cord-347986-ds5hm731	115	3	rate	rate	NN
cord-347986-ds5hm731	115	4	was	be	VBD
cord-347986-ds5hm731	115	5	only	only	RB
cord-347986-ds5hm731	115	6	5/14	5/14	CD
cord-347986-ds5hm731	115	7	in	in	IN
cord-347986-ds5hm731	115	8	MDR	MDR	NNP
cord-347986-ds5hm731	115	9	-	-	HYPH
cord-347986-ds5hm731	115	10	TB	TB	NNP
cord-347986-ds5hm731	115	11	patients	patient	NNS
cord-347986-ds5hm731	115	12	[	[	-LRB-
cord-347986-ds5hm731	115	13	14	14	CD
cord-347986-ds5hm731	115	14	]	]	-RRB-
cord-347986-ds5hm731	115	15	.	.	.
cord-347986-ds5hm731	116	1	Gatifloxacin	Gatifloxacin	NNP
cord-347986-ds5hm731	116	2	,	,	,
cord-347986-ds5hm731	116	3	5	5	CD
cord-347986-ds5hm731	116	4	,	,	,
cord-347986-ds5hm731	116	5	is	be	VBZ
cord-347986-ds5hm731	116	6	another	another	DT
cord-347986-ds5hm731	116	7	methoxyfluoroquinolone	methoxyfluoroquinolone	NN
cord-347986-ds5hm731	116	8	that	that	WDT
cord-347986-ds5hm731	116	9	is	be	VBZ
cord-347986-ds5hm731	116	10	actually	actually	RB
cord-347986-ds5hm731	116	11	furthest	furth	JJS
cord-347986-ds5hm731	116	12	along	along	RB
cord-347986-ds5hm731	116	13	in	in	IN
cord-347986-ds5hm731	116	14	clinical	clinical	JJ
cord-347986-ds5hm731	116	15	development	development	NN
cord-347986-ds5hm731	116	16	for	for	IN
cord-347986-ds5hm731	116	17	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	116	18	treatment	treatment	NN
cord-347986-ds5hm731	116	19	.	.	.
cord-347986-ds5hm731	117	1	Like	like	IN
cord-347986-ds5hm731	117	2	moxifloxacin	moxifloxacin	NNS
cord-347986-ds5hm731	117	3	,	,	,
cord-347986-ds5hm731	117	4	it	-PRON-	PRP
cord-347986-ds5hm731	117	5	is	be	VBZ
cord-347986-ds5hm731	117	6	used	use	VBN
cord-347986-ds5hm731	117	7	to	to	TO
cord-347986-ds5hm731	117	8	treat	treat	VB
cord-347986-ds5hm731	117	9	a	a	DT
cord-347986-ds5hm731	117	10	variety	variety	NN
cord-347986-ds5hm731	117	11	of	of	IN
cord-347986-ds5hm731	117	12	bacterial	bacterial	JJ
cord-347986-ds5hm731	117	13	infections	infection	NNS
cord-347986-ds5hm731	117	14	,	,	,
cord-347986-ds5hm731	117	15	has	have	VBZ
cord-347986-ds5hm731	117	16	been	be	VBN
cord-347986-ds5hm731	117	17	used	use	VBN
cord-347986-ds5hm731	117	18	globally	globally	RB
cord-347986-ds5hm731	117	19	for	for	IN
cord-347986-ds5hm731	117	20	many	many	JJ
cord-347986-ds5hm731	117	21	years	year	NNS
cord-347986-ds5hm731	117	22	,	,	,
cord-347986-ds5hm731	117	23	and	and	CC
cord-347986-ds5hm731	117	24	has	have	VBZ
cord-347986-ds5hm731	117	25	no	no	DT
cord-347986-ds5hm731	117	26	interactions	interaction	NNS
cord-347986-ds5hm731	117	27	with	with	IN
cord-347986-ds5hm731	117	28	ARV	ARV	NNP
cord-347986-ds5hm731	117	29	drugs	drug	NNS
cord-347986-ds5hm731	117	30	.	.	.
cord-347986-ds5hm731	118	1	Gatifloxacin	Gatifloxacin	NNP
cord-347986-ds5hm731	118	2	is	be	VBZ
cord-347986-ds5hm731	118	3	a	a	DT
cord-347986-ds5hm731	118	4	structurally	structurally	RB
cord-347986-ds5hm731	118	5	similar	similar	JJ
cord-347986-ds5hm731	118	6	to	to	IN
cord-347986-ds5hm731	118	7	moxifloxacin	moxifloxacin	NNS
cord-347986-ds5hm731	118	8	and	and	CC
cord-347986-ds5hm731	118	9	likely	likely	JJ
cord-347986-ds5hm731	118	10	to	to	TO
cord-347986-ds5hm731	118	11	have	have	VB
cord-347986-ds5hm731	118	12	the	the	DT
cord-347986-ds5hm731	118	13	same	same	JJ
cord-347986-ds5hm731	118	14	mechanism	mechanism	NN
cord-347986-ds5hm731	118	15	of	of	IN
cord-347986-ds5hm731	118	16	action	action	NN
cord-347986-ds5hm731	118	17	against	against	IN
cord-347986-ds5hm731	118	18	bacterial	bacterial	JJ
cord-347986-ds5hm731	118	19	DNA	dna	NN
cord-347986-ds5hm731	118	20	gyrase	gyrase	NN
cord-347986-ds5hm731	118	21	.	.	.
cord-347986-ds5hm731	119	1	This	this	DT
cord-347986-ds5hm731	119	2	means	mean	VBZ
cord-347986-ds5hm731	119	3	cross	cross	NN
cord-347986-ds5hm731	119	4	-	-	NN
cord-347986-ds5hm731	119	5	resistance	resistance	NN
cord-347986-ds5hm731	119	6	is	be	VBZ
cord-347986-ds5hm731	119	7	possible	possible	JJ
cord-347986-ds5hm731	119	8	between	between	IN
cord-347986-ds5hm731	119	9	these	these	DT
cord-347986-ds5hm731	119	10	two	two	CD
cord-347986-ds5hm731	119	11	drugs	drug	NNS
cord-347986-ds5hm731	119	12	.	.	.
cord-347986-ds5hm731	120	1	Gatifloxacin	Gatifloxacin	NNP
cord-347986-ds5hm731	120	2	's	's	POS
cord-347986-ds5hm731	120	3	toxicity	toxicity	NN
cord-347986-ds5hm731	120	4	and	and	CC
cord-347986-ds5hm731	120	5	drug	drug	NN
cord-347986-ds5hm731	120	6	-	-	HYPH
cord-347986-ds5hm731	120	7	drug	drug	NN
cord-347986-ds5hm731	120	8	interaction	interaction	NN
cord-347986-ds5hm731	120	9	profile	profile	NN
cord-347986-ds5hm731	120	10	is	be	VBZ
cord-347986-ds5hm731	120	11	similar	similar	JJ
cord-347986-ds5hm731	120	12	to	to	IN
cord-347986-ds5hm731	120	13	moxifloxacin	moxifloxacin	NNP
cord-347986-ds5hm731	120	14	's	's	POS
cord-347986-ds5hm731	120	15	.	.	.
cord-347986-ds5hm731	121	1	Early	early	JJ
cord-347986-ds5hm731	121	2	clinical	clinical	JJ
cord-347986-ds5hm731	121	3	studies	study	NNS
cord-347986-ds5hm731	121	4	in	in	IN
cord-347986-ds5hm731	121	5	Brazil	Brazil	NNP
cord-347986-ds5hm731	121	6	have	have	VBP
cord-347986-ds5hm731	121	7	shown	show	VBN
cord-347986-ds5hm731	121	8	gatifloxacin	gatifloxacin	NNS
cord-347986-ds5hm731	121	9	to	to	TO
cord-347986-ds5hm731	121	10	possess	possess	VB
cord-347986-ds5hm731	121	11	equivalent	equivalent	JJ
cord-347986-ds5hm731	121	12	antituberculosis	antituberculosis	NN
cord-347986-ds5hm731	121	13	activity	activity	NN
cord-347986-ds5hm731	121	14	to	to	IN
cord-347986-ds5hm731	121	15	moxifloxacin	moxifloxacin	NNS
cord-347986-ds5hm731	121	16	and	and	CC
cord-347986-ds5hm731	121	17	similar	similar	JJ
cord-347986-ds5hm731	121	18	,	,	,
cord-347986-ds5hm731	121	19	but	but	CC
cord-347986-ds5hm731	121	20	slightly	slightly	RB
cord-347986-ds5hm731	121	21	less	less	RBR
cord-347986-ds5hm731	121	22	potent	potent	JJ
cord-347986-ds5hm731	121	23	,	,	,
cord-347986-ds5hm731	121	24	activity	activity	NN
cord-347986-ds5hm731	121	25	to	to	IN
cord-347986-ds5hm731	121	26	isoniazid	isoniazid	NN
cord-347986-ds5hm731	121	27	[	[	-LRB-
cord-347986-ds5hm731	121	28	15	15	CD
cord-347986-ds5hm731	121	29	]	]	-RRB-
cord-347986-ds5hm731	121	30	.	.	.
cord-347986-ds5hm731	122	1	One	one	CD
cord-347986-ds5hm731	122	2	murine	murine	JJ
cord-347986-ds5hm731	122	3	study	study	NN
cord-347986-ds5hm731	122	4	suggests	suggest	VBZ
cord-347986-ds5hm731	122	5	that	that	IN
cord-347986-ds5hm731	122	6	gatifloxacin	gatifloxacin	NNS
cord-347986-ds5hm731	122	7	in	in	IN
cord-347986-ds5hm731	122	8	combination	combination	NN
cord-347986-ds5hm731	122	9	with	with	IN
cord-347986-ds5hm731	122	10	ethionamide	ethionamide	NN
cord-347986-ds5hm731	122	11	or	or	CC
cord-347986-ds5hm731	122	12	pyrazinamide	pyrazinamide	NN
cord-347986-ds5hm731	122	13	,	,	,
cord-347986-ds5hm731	122	14	could	could	MD
cord-347986-ds5hm731	122	15	be	be	VB
cord-347986-ds5hm731	122	16	an	an	DT
cord-347986-ds5hm731	122	17	alternative	alternative	JJ
cord-347986-ds5hm731	122	18	regimen	regimen	NN
cord-347986-ds5hm731	122	19	to	to	TO
cord-347986-ds5hm731	122	20	cure	cure	VB
cord-347986-ds5hm731	122	21	active	active	JJ
cord-347986-ds5hm731	122	22	TB	TB	NNP
cord-347986-ds5hm731	122	23	.	.	.
cord-347986-ds5hm731	123	1	This	this	DT
cord-347986-ds5hm731	123	2	would	would	MD
cord-347986-ds5hm731	123	3	be	be	VB
cord-347986-ds5hm731	123	4	important	important	JJ
cord-347986-ds5hm731	123	5	in	in	IN
cord-347986-ds5hm731	123	6	treating	treat	VBG
cord-347986-ds5hm731	123	7	patients	patient	NNS
cord-347986-ds5hm731	123	8	with	with	IN
cord-347986-ds5hm731	123	9	drug	drug	NN
cord-347986-ds5hm731	123	10	-	-	HYPH
cord-347986-ds5hm731	123	11	resistant	resistant	JJ
cord-347986-ds5hm731	123	12	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	123	13	where	where	WRB
cord-347986-ds5hm731	123	14	the	the	DT
cord-347986-ds5hm731	123	15	standard	standard	JJ
cord-347986-ds5hm731	123	16	isoniazid	isoniazid	NN
cord-347986-ds5hm731	123	17	/	/	,
cord-347986-ds5hm731	123	18	rifampin	rifampin	NN
cord-347986-ds5hm731	123	19	-	-	HYPH
cord-347986-ds5hm731	123	20	containing	contain	VBG
cord-347986-ds5hm731	123	21	regimen	regimen	NN
cord-347986-ds5hm731	123	22	would	would	MD
cord-347986-ds5hm731	123	23	be	be	VB
cord-347986-ds5hm731	123	24	ineffective	ineffective	JJ
cord-347986-ds5hm731	123	25	[	[	-LRB-
cord-347986-ds5hm731	123	26	16	16	CD
cord-347986-ds5hm731	123	27	]	]	-RRB-
cord-347986-ds5hm731	123	28	.	.	.
cord-347986-ds5hm731	124	1	A	a	DT
cord-347986-ds5hm731	124	2	large	large	JJ
cord-347986-ds5hm731	124	3	multicenter	multicenter	JJ
cord-347986-ds5hm731	124	4	phase	phase	NN
cord-347986-ds5hm731	124	5	III	iii	CD
cord-347986-ds5hm731	124	6	clinical	clinical	JJ
cord-347986-ds5hm731	124	7	trial	trial	NN
cord-347986-ds5hm731	124	8	is	be	VBZ
cord-347986-ds5hm731	124	9	currently	currently	RB
cord-347986-ds5hm731	124	10	enrolling	enrol	VBG
cord-347986-ds5hm731	124	11	a	a	DT
cord-347986-ds5hm731	124	12	planned	planned	JJ
cord-347986-ds5hm731	124	13	2000	2000	CD
cord-347986-ds5hm731	124	14	patients	patient	NNS
cord-347986-ds5hm731	124	15	in	in	IN
cord-347986-ds5hm731	124	16	South	South	NNP
cord-347986-ds5hm731	124	17	Africa	Africa	NNP
cord-347986-ds5hm731	124	18	,	,	,
cord-347986-ds5hm731	124	19	Senegal	Senegal	NNP
cord-347986-ds5hm731	124	20	,	,	,
cord-347986-ds5hm731	124	21	Kenya	Kenya	NNP
cord-347986-ds5hm731	124	22	,	,	,
cord-347986-ds5hm731	124	23	Benin	Benin	NNP
cord-347986-ds5hm731	124	24	,	,	,
cord-347986-ds5hm731	124	25	and	and	CC
cord-347986-ds5hm731	124	26	Guinea	Guinea	NNP
cord-347986-ds5hm731	124	27	to	to	TO
cord-347986-ds5hm731	124	28	evaluate	evaluate	VB
cord-347986-ds5hm731	124	29	whether	whether	IN
cord-347986-ds5hm731	124	30	using	use	VBG
cord-347986-ds5hm731	124	31	gatifloxacin	gatifloxacin	NNS
cord-347986-ds5hm731	124	32	instead	instead	RB
cord-347986-ds5hm731	124	33	of	of	IN
cord-347986-ds5hm731	124	34	ethambutol	ethambutol	NNP
cord-347986-ds5hm731	124	35	can	can	MD
cord-347986-ds5hm731	124	36	shorten	shorten	VB
cord-347986-ds5hm731	124	37	the	the	DT
cord-347986-ds5hm731	124	38	standard	standard	JJ
cord-347986-ds5hm731	124	39	TB	TB	NNP
cord-347986-ds5hm731	124	40	treatment	treatment	NN
cord-347986-ds5hm731	124	41	in	in	IN
cord-347986-ds5hm731	124	42	adults	adult	NNS
cord-347986-ds5hm731	124	43	to	to	IN
cord-347986-ds5hm731	124	44	four	four	CD
cord-347986-ds5hm731	124	45	months	month	NNS
cord-347986-ds5hm731	124	46	.	.	.
cord-347986-ds5hm731	125	1	This	this	DT
cord-347986-ds5hm731	125	2	study	study	NN
cord-347986-ds5hm731	125	3	began	begin	VBD
cord-347986-ds5hm731	125	4	in	in	IN
cord-347986-ds5hm731	125	5	2005	2005	CD
cord-347986-ds5hm731	125	6	,	,	,
cord-347986-ds5hm731	125	7	and	and	CC
cord-347986-ds5hm731	125	8	is	be	VBZ
cord-347986-ds5hm731	125	9	to	to	TO
cord-347986-ds5hm731	125	10	be	be	VB
cord-347986-ds5hm731	125	11	completed	complete	VBN
cord-347986-ds5hm731	125	12	in	in	IN
cord-347986-ds5hm731	125	13	2009	2009	CD
cord-347986-ds5hm731	125	14	[	[	-LRB-
cord-347986-ds5hm731	125	15	17	17	CD
cord-347986-ds5hm731	125	16	]	]	-RRB-
cord-347986-ds5hm731	125	17	.	.	.
cord-347986-ds5hm731	126	1	An	an	DT
cord-347986-ds5hm731	126	2	additional	additional	JJ
cord-347986-ds5hm731	126	3	quinolone	quinolone	NN
cord-347986-ds5hm731	126	4	derivative	derivative	JJ
cord-347986-ds5hm731	126	5	,	,	,
cord-347986-ds5hm731	126	6	TMC207	TMC207	NNP
cord-347986-ds5hm731	126	7	,	,	,
cord-347986-ds5hm731	126	8	6	6	CD
cord-347986-ds5hm731	126	9	,	,	,
cord-347986-ds5hm731	126	10	(	(	-LRB-
cord-347986-ds5hm731	126	11	formerly	formerly	RB
cord-347986-ds5hm731	126	12	known	know	VBN
cord-347986-ds5hm731	126	13	as	as	IN
cord-347986-ds5hm731	126	14	R207910	R207910	NNP
cord-347986-ds5hm731	126	15	)	)	-RRB-
cord-347986-ds5hm731	126	16	is	be	VBZ
cord-347986-ds5hm731	126	17	currently	currently	RB
cord-347986-ds5hm731	126	18	being	be	VBG
cord-347986-ds5hm731	126	19	studied	study	VBN
cord-347986-ds5hm731	126	20	in	in	IN
cord-347986-ds5hm731	126	21	Phase	Phase	NNP
cord-347986-ds5hm731	126	22	II	ii	CD
cord-347986-ds5hm731	126	23	trials	trial	NNS
cord-347986-ds5hm731	126	24	in	in	IN
cord-347986-ds5hm731	126	25	patients	patient	NNS
cord-347986-ds5hm731	126	26	with	with	IN
cord-347986-ds5hm731	126	27	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	126	28	.	.	.
cord-347986-ds5hm731	127	1	It	-PRON-	PRP
cord-347986-ds5hm731	127	2	is	be	VBZ
cord-347986-ds5hm731	127	3	a	a	DT
cord-347986-ds5hm731	127	4	diarylquinolone	diarylquinolone	NN
cord-347986-ds5hm731	127	5	,	,	,
cord-347986-ds5hm731	127	6	with	with	IN
cord-347986-ds5hm731	127	7	activity	activity	NN
cord-347986-ds5hm731	127	8	against	against	IN
cord-347986-ds5hm731	127	9	both	both	CC
cord-347986-ds5hm731	127	10	sensitive	sensitive	JJ
cord-347986-ds5hm731	127	11	and	and	CC
cord-347986-ds5hm731	127	12	MDR	MDR	NNP
cord-347986-ds5hm731	127	13	strains	strain	NNS
cord-347986-ds5hm731	127	14	of	of	IN
cord-347986-ds5hm731	127	15	TB	TB	NNP
cord-347986-ds5hm731	127	16	.	.	.
cord-347986-ds5hm731	128	1	In	in	IN
cord-347986-ds5hm731	128	2	a	a	DT
cord-347986-ds5hm731	128	3	murine	murine	JJ
cord-347986-ds5hm731	128	4	model	model	NN
cord-347986-ds5hm731	128	5	it	-PRON-	PRP
cord-347986-ds5hm731	128	6	appeared	appear	VBD
cord-347986-ds5hm731	128	7	equivalent	equivalent	JJ
cord-347986-ds5hm731	128	8	to	to	IN
cord-347986-ds5hm731	128	9	both	both	CC
cord-347986-ds5hm731	128	10	isoniazid	isoniazid	NN
cord-347986-ds5hm731	128	11	and	and	CC
cord-347986-ds5hm731	128	12	rifampin	rifampin	NN
cord-347986-ds5hm731	128	13	at	at	IN
cord-347986-ds5hm731	128	14	lower	low	JJR
cord-347986-ds5hm731	128	15	doses	dose	NNS
cord-347986-ds5hm731	128	16	,	,	,
cord-347986-ds5hm731	128	17	and	and	CC
cord-347986-ds5hm731	128	18	superior	superior	JJ
cord-347986-ds5hm731	128	19	to	to	IN
cord-347986-ds5hm731	128	20	the	the	DT
cord-347986-ds5hm731	128	21	combination	combination	NN
cord-347986-ds5hm731	128	22	of	of	IN
cord-347986-ds5hm731	128	23	isoniazid	isoniazid	NN
cord-347986-ds5hm731	128	24	,	,	,
cord-347986-ds5hm731	128	25	rifampin	rifampin	NN
cord-347986-ds5hm731	128	26	,	,	,
cord-347986-ds5hm731	128	27	and	and	CC
cord-347986-ds5hm731	128	28	pyrazinamide	pyrazinamide	NN
cord-347986-ds5hm731	128	29	bactericidal	bactericidal	JJ
cord-347986-ds5hm731	128	30	activity	activity	NN
cord-347986-ds5hm731	128	31	by	by	IN
cord-347986-ds5hm731	128	32	at	at	RB
cord-347986-ds5hm731	128	33	least	least	JJS
cord-347986-ds5hm731	128	34	1	1	CD
cord-347986-ds5hm731	128	35	log	log	NN
cord-347986-ds5hm731	128	36	unit	unit	NN
cord-347986-ds5hm731	128	37	when	when	WRB
cord-347986-ds5hm731	128	38	combined	combine	VBN
cord-347986-ds5hm731	128	39	at	at	IN
cord-347986-ds5hm731	128	40	a	a	DT
cord-347986-ds5hm731	128	41	higher	high	JJR
cord-347986-ds5hm731	128	42	dose	dose	NN
cord-347986-ds5hm731	128	43	with	with	IN
cord-347986-ds5hm731	128	44	any	any	DT
cord-347986-ds5hm731	128	45	two	two	CD
cord-347986-ds5hm731	128	46	of	of	IN
cord-347986-ds5hm731	128	47	the	the	DT
cord-347986-ds5hm731	128	48	three	three	CD
cord-347986-ds5hm731	128	49	.	.	.
cord-347986-ds5hm731	129	1	It	-PRON-	PRP
cord-347986-ds5hm731	129	2	even	even	RB
cord-347986-ds5hm731	129	3	appeared	appear	VBD
cord-347986-ds5hm731	129	4	to	to	TO
cord-347986-ds5hm731	129	5	be	be	VB
cord-347986-ds5hm731	129	6	superior	superior	JJ
cord-347986-ds5hm731	129	7	to	to	IN
cord-347986-ds5hm731	129	8	the	the	DT
cord-347986-ds5hm731	129	9	combination	combination	NN
cord-347986-ds5hm731	129	10	as	as	IN
cord-347986-ds5hm731	129	11	monotherapy	monotherapy	NN
cord-347986-ds5hm731	129	12	.	.	.
cord-347986-ds5hm731	130	1	In	in	IN
cord-347986-ds5hm731	130	2	combination	combination	NN
cord-347986-ds5hm731	130	3	with	with	IN
cord-347986-ds5hm731	131	1	isoniazid	isoniazid	NNP
cord-347986-ds5hm731	131	2	or	or	CC
cord-347986-ds5hm731	131	3	rifampin	rifampin	NN
cord-347986-ds5hm731	131	4	,	,	,
cord-347986-ds5hm731	131	5	TMC207	TMC207	NNP
cord-347986-ds5hm731	131	6	decrease	decrease	NN
cord-347986-ds5hm731	131	7	TB	TB	NNP
cord-347986-ds5hm731	131	8	sterilization	sterilization	NN
cord-347986-ds5hm731	131	9	time	time	NN
cord-347986-ds5hm731	131	10	from	from	IN
cord-347986-ds5hm731	131	11	four	four	CD
cord-347986-ds5hm731	131	12	to	to	IN
cord-347986-ds5hm731	131	13	less	less	JJR
cord-347986-ds5hm731	131	14	than	than	IN
cord-347986-ds5hm731	131	15	two	two	CD
cord-347986-ds5hm731	131	16	months	month	NNS
cord-347986-ds5hm731	131	17	.	.	.
cord-347986-ds5hm731	132	1	Its	-PRON-	PRP$
cord-347986-ds5hm731	132	2	activity	activity	NN
cord-347986-ds5hm731	132	3	appears	appear	VBZ
cord-347986-ds5hm731	132	4	to	to	TO
cord-347986-ds5hm731	132	5	be	be	VB
cord-347986-ds5hm731	132	6	directed	direct	VBN
cord-347986-ds5hm731	132	7	against	against	IN
cord-347986-ds5hm731	132	8	mycobacterial	mycobacterial	NNP
cord-347986-ds5hm731	132	9	ATP	ATP	NNP
cord-347986-ds5hm731	132	10	synthase	synthase	NN
cord-347986-ds5hm731	132	11	,	,	,
cord-347986-ds5hm731	132	12	giving	give	VBG
cord-347986-ds5hm731	132	13	it	-PRON-	PRP
cord-347986-ds5hm731	132	14	a	a	DT
cord-347986-ds5hm731	132	15	unique	unique	JJ
cord-347986-ds5hm731	132	16	mechanism	mechanism	NN
cord-347986-ds5hm731	132	17	of	of	IN
cord-347986-ds5hm731	132	18	action	action	NN
cord-347986-ds5hm731	132	19	,	,	,
cord-347986-ds5hm731	132	20	compared	compare	VBN
cord-347986-ds5hm731	132	21	with	with	IN
cord-347986-ds5hm731	132	22	other	other	JJ
cord-347986-ds5hm731	132	23	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	132	24	drugs	drug	NNS
cord-347986-ds5hm731	132	25	,	,	,
cord-347986-ds5hm731	132	26	including	include	VBG
cord-347986-ds5hm731	132	27	fluoroquinolones	fluoroquinolone	NNS
cord-347986-ds5hm731	132	28	like	like	IN
cord-347986-ds5hm731	132	29	moxifloxacin	moxifloxacin	NNS
cord-347986-ds5hm731	132	30	.	.	.
cord-347986-ds5hm731	133	1	Moreover	moreover	RB
cord-347986-ds5hm731	133	2	,	,	,
cord-347986-ds5hm731	133	3	the	the	DT
cord-347986-ds5hm731	133	4	half	half	JJ
cord-347986-ds5hm731	133	5	-	-	HYPH
cord-347986-ds5hm731	133	6	life	life	NN
cord-347986-ds5hm731	133	7	was	be	VBD
cord-347986-ds5hm731	133	8	greater	great	JJR
cord-347986-ds5hm731	133	9	than	than	IN
cord-347986-ds5hm731	133	10	24	24	CD
cord-347986-ds5hm731	133	11	hours	hour	NNS
cord-347986-ds5hm731	133	12	,	,	,
cord-347986-ds5hm731	133	13	suggesting	suggest	VBG
cord-347986-ds5hm731	133	14	once	once	IN
cord-347986-ds5hm731	133	15	weekly	weekly	JJ
cord-347986-ds5hm731	133	16	dosing	dosing	NN
cord-347986-ds5hm731	133	17	is	be	VBZ
cord-347986-ds5hm731	133	18	possible	possible	JJ
cord-347986-ds5hm731	133	19	[	[	-LRB-
cord-347986-ds5hm731	133	20	18	18	CD
cord-347986-ds5hm731	133	21	]	]	-RRB-
cord-347986-ds5hm731	133	22	.	.	.
cord-347986-ds5hm731	133	23	 	 	_SP
cord-347986-ds5hm731	134	1	PA-824	pa-824	NN
cord-347986-ds5hm731	134	2	,	,	,
cord-347986-ds5hm731	134	3	7	7	CD
cord-347986-ds5hm731	134	4	,	,	,
cord-347986-ds5hm731	134	5	is	be	VBZ
cord-347986-ds5hm731	134	6	a	a	DT
cord-347986-ds5hm731	134	7	nitroimidazopyran	nitroimidazopyran	NN
cord-347986-ds5hm731	134	8	discovered	discover	VBN
cord-347986-ds5hm731	134	9	in	in	IN
cord-347986-ds5hm731	134	10	1995	1995	CD
cord-347986-ds5hm731	134	11	as	as	IN
cord-347986-ds5hm731	134	12	a	a	DT
cord-347986-ds5hm731	134	13	potential	potential	JJ
cord-347986-ds5hm731	134	14	cancer	cancer	NN
cord-347986-ds5hm731	134	15	drug	drug	NN
cord-347986-ds5hm731	134	16	.	.	.
cord-347986-ds5hm731	135	1	In	in	IN
cord-347986-ds5hm731	135	2	2000	2000	CD
cord-347986-ds5hm731	135	3	,	,	,
cord-347986-ds5hm731	135	4	a	a	DT
cord-347986-ds5hm731	135	5	study	study	NN
cord-347986-ds5hm731	135	6	revealed	reveal	VBD
cord-347986-ds5hm731	135	7	its	-PRON-	PRP$
cord-347986-ds5hm731	135	8	potency	potency	NN
cord-347986-ds5hm731	135	9	against	against	IN
cord-347986-ds5hm731	135	10	M.	M.	NNP
cord-347986-ds5hm731	135	11	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	135	12	[	[	-LRB-
cord-347986-ds5hm731	135	13	19	19	CD
cord-347986-ds5hm731	135	14	]	]	-RRB-
cord-347986-ds5hm731	135	15	.	.	.
cord-347986-ds5hm731	136	1	It	-PRON-	PRP
cord-347986-ds5hm731	136	2	has	have	VBZ
cord-347986-ds5hm731	136	3	a	a	DT
cord-347986-ds5hm731	136	4	novel	novel	JJ
cord-347986-ds5hm731	136	5	mechanism	mechanism	NN
cord-347986-ds5hm731	136	6	of	of	IN
cord-347986-ds5hm731	136	7	action	action	NN
cord-347986-ds5hm731	136	8	inhibiting	inhibit	VBG
cord-347986-ds5hm731	136	9	protein	protein	NN
cord-347986-ds5hm731	136	10	and	and	CC
cord-347986-ds5hm731	136	11	lipid	lipid	NN
cord-347986-ds5hm731	136	12	synthesis	synthesis	NN
cord-347986-ds5hm731	136	13	,	,	,
cord-347986-ds5hm731	136	14	which	which	WDT
cord-347986-ds5hm731	136	15	is	be	VBZ
cord-347986-ds5hm731	136	16	effective	effective	JJ
cord-347986-ds5hm731	136	17	against	against	IN
cord-347986-ds5hm731	136	18	both	both	DT
cord-347986-ds5hm731	136	19	TB	TB	NNP
cord-347986-ds5hm731	136	20	and	and	CC
cord-347986-ds5hm731	136	21	tested	test	VBD
cord-347986-ds5hm731	136	22	clinical	clinical	JJ
cord-347986-ds5hm731	136	23	isolates	isolate	NNS
cord-347986-ds5hm731	136	24	of	of	IN
cord-347986-ds5hm731	136	25	MDR	MDR	NNP
cord-347986-ds5hm731	136	26	-	-	HYPH
cord-347986-ds5hm731	136	27	TB	TB	NNP
cord-347986-ds5hm731	136	28	.	.	.
cord-347986-ds5hm731	137	1	It	-PRON-	PRP
cord-347986-ds5hm731	137	2	attacks	attack	VBZ
cord-347986-ds5hm731	137	3	the	the	DT
cord-347986-ds5hm731	137	4	mycobacteria	mycobacterium	NNS
cord-347986-ds5hm731	137	5	in	in	IN
cord-347986-ds5hm731	137	6	both	both	CC
cord-347986-ds5hm731	137	7	the	the	DT
cord-347986-ds5hm731	137	8	initial	initial	JJ
cord-347986-ds5hm731	137	9	,	,	,
cord-347986-ds5hm731	137	10	intensive	intensive	JJ
cord-347986-ds5hm731	137	11	phase	phase	NN
cord-347986-ds5hm731	137	12	of	of	IN
cord-347986-ds5hm731	137	13	TB	TB	NNP
cord-347986-ds5hm731	137	14	therapy	therapy	NN
cord-347986-ds5hm731	137	15	,	,	,
cord-347986-ds5hm731	137	16	as	as	RB
cord-347986-ds5hm731	137	17	well	well	RB
cord-347986-ds5hm731	137	18	as	as	IN
cord-347986-ds5hm731	137	19	the	the	DT
cord-347986-ds5hm731	137	20	later	later	JJ
cord-347986-ds5hm731	137	21	,	,	,
cord-347986-ds5hm731	137	22	continuation	continuation	NN
cord-347986-ds5hm731	137	23	phase	phase	NN
cord-347986-ds5hm731	137	24	.	.	.
cord-347986-ds5hm731	138	1	In	in	IN
cord-347986-ds5hm731	138	2	the	the	DT
cord-347986-ds5hm731	138	3	intensive	intensive	JJ
cord-347986-ds5hm731	138	4	phase	phase	NN
cord-347986-ds5hm731	138	5	,	,	,
cord-347986-ds5hm731	138	6	PA-824	pa-824	NN
cord-347986-ds5hm731	138	7	has	have	VBZ
cord-347986-ds5hm731	138	8	bactericidal	bactericidal	JJ
cord-347986-ds5hm731	138	9	activity	activity	NN
cord-347986-ds5hm731	138	10	comparable	comparable	JJ
cord-347986-ds5hm731	138	11	to	to	IN
cord-347986-ds5hm731	138	12	isoniazid	isoniazid	NN
cord-347986-ds5hm731	138	13	,	,	,
cord-347986-ds5hm731	138	14	and	and	CC
cord-347986-ds5hm731	138	15	in	in	IN
cord-347986-ds5hm731	138	16	the	the	DT
cord-347986-ds5hm731	138	17	continuation	continuation	NN
cord-347986-ds5hm731	138	18	phase	phase	NN
cord-347986-ds5hm731	138	19	,	,	,
cord-347986-ds5hm731	138	20	its	-PRON-	PRP$
cord-347986-ds5hm731	138	21	bactericidal	bactericidal	JJ
cord-347986-ds5hm731	138	22	activity	activity	NN
cord-347986-ds5hm731	138	23	is	be	VBZ
cord-347986-ds5hm731	138	24	close	close	JJ
cord-347986-ds5hm731	138	25	to	to	IN
cord-347986-ds5hm731	138	26	the	the	DT
cord-347986-ds5hm731	138	27	combination	combination	NN
cord-347986-ds5hm731	138	28	of	of	IN
cord-347986-ds5hm731	138	29	isoniazid	isoniazid	NN
cord-347986-ds5hm731	138	30	and	and	CC
cord-347986-ds5hm731	138	31	rifampin	rifampin	NN
cord-347986-ds5hm731	138	32	.	.	.
cord-347986-ds5hm731	139	1	PA-824	pa-824	NN
cord-347986-ds5hm731	139	2	also	also	RB
cord-347986-ds5hm731	139	3	has	have	VBZ
cord-347986-ds5hm731	139	4	activity	activity	NN
cord-347986-ds5hm731	139	5	against	against	IN
cord-347986-ds5hm731	139	6	both	both	DT
cord-347986-ds5hm731	139	7	actively	actively	RB
cord-347986-ds5hm731	139	8	replicating	replicate	VBG
cord-347986-ds5hm731	139	9	and	and	CC
cord-347986-ds5hm731	139	10	the	the	DT
cord-347986-ds5hm731	139	11	static	static	JJ
cord-347986-ds5hm731	139	12	,	,	,
cord-347986-ds5hm731	139	13	slow	slow	JJ
cord-347986-ds5hm731	139	14	growing	grow	VBG
cord-347986-ds5hm731	139	15	mycobacteria	mycobacterium	NNS
cord-347986-ds5hm731	139	16	.	.	.
cord-347986-ds5hm731	140	1	This	this	DT
cord-347986-ds5hm731	140	2	has	have	VBZ
cord-347986-ds5hm731	140	3	the	the	DT
cord-347986-ds5hm731	140	4	potential	potential	NN
cord-347986-ds5hm731	140	5	for	for	IN
cord-347986-ds5hm731	140	6	shortening	shorten	VBG
cord-347986-ds5hm731	140	7	the	the	DT
cord-347986-ds5hm731	140	8	course	course	NN
cord-347986-ds5hm731	140	9	of	of	IN
cord-347986-ds5hm731	140	10	therapy	therapy	NN
cord-347986-ds5hm731	140	11	,	,	,
cord-347986-ds5hm731	140	12	since	since	IN
cord-347986-ds5hm731	140	13	many	many	JJ
cord-347986-ds5hm731	140	14	current	current	JJ
cord-347986-ds5hm731	140	15	drugs	drug	NNS
cord-347986-ds5hm731	140	16	are	be	VBP
cord-347986-ds5hm731	140	17	only	only	RB
cord-347986-ds5hm731	140	18	active	active	JJ
cord-347986-ds5hm731	140	19	against	against	IN
cord-347986-ds5hm731	140	20	actively	actively	RB
cord-347986-ds5hm731	140	21	replicating	replicate	VBG
cord-347986-ds5hm731	140	22	mycobacteria	mycobacterium	NNS
cord-347986-ds5hm731	140	23	,	,	,
cord-347986-ds5hm731	140	24	and	and	CC
cord-347986-ds5hm731	140	25	M.	M.	NNP
cord-347986-ds5hm731	140	26	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	140	27	spends	spend	VBZ
cord-347986-ds5hm731	140	28	weeks	week	NNS
cord-347986-ds5hm731	140	29	to	to	IN
cord-347986-ds5hm731	140	30	months	month	NNS
cord-347986-ds5hm731	140	31	in	in	IN
cord-347986-ds5hm731	140	32	its	-PRON-	PRP$
cord-347986-ds5hm731	140	33	static	static	JJ
cord-347986-ds5hm731	140	34	,	,	,
cord-347986-ds5hm731	140	35	slow	slow	RB
cord-347986-ds5hm731	140	36	-	-	HYPH
cord-347986-ds5hm731	140	37	growing	grow	VBG
cord-347986-ds5hm731	140	38	phase	phase	NN
cord-347986-ds5hm731	140	39	.	.	.
cord-347986-ds5hm731	141	1	In	in	IN
cord-347986-ds5hm731	141	2	a	a	DT
cord-347986-ds5hm731	141	3	murine	murine	JJ
cord-347986-ds5hm731	141	4	model	model	NN
cord-347986-ds5hm731	141	5	,	,	,
cord-347986-ds5hm731	141	6	PA-824	pa-824	NN
cord-347986-ds5hm731	141	7	was	be	VBD
cord-347986-ds5hm731	141	8	more	more	RBR
cord-347986-ds5hm731	141	9	potent	potent	JJ
cord-347986-ds5hm731	141	10	than	than	IN
cord-347986-ds5hm731	141	11	rifampin	rifampin	NN
cord-347986-ds5hm731	141	12	when	when	WRB
cord-347986-ds5hm731	141	13	used	use	VBN
cord-347986-ds5hm731	141	14	in	in	IN
cord-347986-ds5hm731	141	15	combination	combination	NN
cord-347986-ds5hm731	141	16	with	with	IN
cord-347986-ds5hm731	141	17	moxifloxacin	moxifloxacin	NNS
cord-347986-ds5hm731	141	18	and	and	CC
cord-347986-ds5hm731	141	19	pyrazinamide	pyrazinamide	NN
cord-347986-ds5hm731	141	20	,	,	,
cord-347986-ds5hm731	141	21	and	and	CC
cord-347986-ds5hm731	141	22	that	that	IN
cord-347986-ds5hm731	141	23	when	when	WRB
cord-347986-ds5hm731	141	24	all	all	DT
cord-347986-ds5hm731	141	25	four	four	CD
cord-347986-ds5hm731	141	26	drugs	drug	NNS
cord-347986-ds5hm731	141	27	were	be	VBD
cord-347986-ds5hm731	141	28	used	use	VBN
cord-347986-ds5hm731	141	29	together	together	RB
cord-347986-ds5hm731	141	30	,	,	,
cord-347986-ds5hm731	141	31	the	the	DT
cord-347986-ds5hm731	141	32	duration	duration	NN
cord-347986-ds5hm731	141	33	of	of	IN
cord-347986-ds5hm731	141	34	treatment	treatment	NN
cord-347986-ds5hm731	141	35	could	could	MD
cord-347986-ds5hm731	141	36	be	be	VB
cord-347986-ds5hm731	141	37	reduced	reduce	VBN
cord-347986-ds5hm731	141	38	to	to	IN
cord-347986-ds5hm731	141	39	3	3	CD
cord-347986-ds5hm731	141	40	months	month	NNS
cord-347986-ds5hm731	141	41	or	or	CC
cord-347986-ds5hm731	141	42	less	less	JJR
cord-347986-ds5hm731	141	43	[	[	-LRB-
cord-347986-ds5hm731	141	44	20	20	CD
cord-347986-ds5hm731	141	45	]	]	-RRB-
cord-347986-ds5hm731	141	46	.	.	.
cord-347986-ds5hm731	142	1	PA-824	pa-824	NN
cord-347986-ds5hm731	142	2	successfully	successfully	RB
cord-347986-ds5hm731	142	3	completed	complete	VBD
cord-347986-ds5hm731	142	4	a	a	DT
cord-347986-ds5hm731	142	5	phase	phase	NN
cord-347986-ds5hm731	142	6	I	-PRON-	PRP
cord-347986-ds5hm731	142	7	clinical	clinical	JJ
cord-347986-ds5hm731	142	8	trial	trial	NN
cord-347986-ds5hm731	142	9	in	in	IN
cord-347986-ds5hm731	142	10	the	the	DT
cord-347986-ds5hm731	142	11	U.S.	U.S.	NNP
cord-347986-ds5hm731	142	12	in	in	IN
cord-347986-ds5hm731	142	13	August	August	NNP
cord-347986-ds5hm731	142	14	2005	2005	CD
cord-347986-ds5hm731	142	15	,	,	,
cord-347986-ds5hm731	142	16	and	and	CC
cord-347986-ds5hm731	142	17	a	a	DT
cord-347986-ds5hm731	142	18	phase	phase	NN
cord-347986-ds5hm731	142	19	II	II	NNP
cord-347986-ds5hm731	142	20	trial	trial	NN
cord-347986-ds5hm731	142	21	is	be	VBZ
cord-347986-ds5hm731	142	22	planned	plan	VBN
cord-347986-ds5hm731	142	23	for	for	IN
cord-347986-ds5hm731	142	24	later	later	RB
cord-347986-ds5hm731	142	25	in	in	IN
cord-347986-ds5hm731	142	26	2006	2006	CD
cord-347986-ds5hm731	142	27	,	,	,
cord-347986-ds5hm731	142	28	ending	end	VBG
cord-347986-ds5hm731	142	29	in	in	IN
cord-347986-ds5hm731	142	30	2008	2008	CD
cord-347986-ds5hm731	142	31	.	.	.
cord-347986-ds5hm731	143	1	PA-824	pa-824	NN
cord-347986-ds5hm731	143	2	has	have	VBZ
cord-347986-ds5hm731	143	3	a	a	DT
cord-347986-ds5hm731	143	4	bioavailability	bioavailability	NN
cord-347986-ds5hm731	143	5	of	of	IN
cord-347986-ds5hm731	143	6	about	about	RB
cord-347986-ds5hm731	143	7	40	40	CD
cord-347986-ds5hm731	143	8	%	%	NN
cord-347986-ds5hm731	143	9	and	and	CC
cord-347986-ds5hm731	143	10	single	single	JJ
cord-347986-ds5hm731	143	11	oral	oral	JJ
cord-347986-ds5hm731	143	12	dose	dose	NN
cord-347986-ds5hm731	143	13	rapidly	rapidly	RB
cord-347986-ds5hm731	143	14	travel	travel	VBP
cord-347986-ds5hm731	143	15	to	to	IN
cord-347986-ds5hm731	143	16	important	important	JJ
cord-347986-ds5hm731	143	17	target	target	NN
cord-347986-ds5hm731	143	18	sites	site	NNS
cord-347986-ds5hm731	143	19	like	like	IN
cord-347986-ds5hm731	143	20	the	the	DT
cord-347986-ds5hm731	143	21	lung	lung	NN
cord-347986-ds5hm731	143	22	and	and	CC
cord-347986-ds5hm731	143	23	spleen	spleen	NNS
cord-347986-ds5hm731	143	24	.	.	.
cord-347986-ds5hm731	144	1	PA-824	pa-824	NN
cord-347986-ds5hm731	144	2	also	also	RB
cord-347986-ds5hm731	144	3	does	do	VBZ
cord-347986-ds5hm731	144	4	not	not	RB
cord-347986-ds5hm731	144	5	inhibit	inhibit	VB
cord-347986-ds5hm731	144	6	the	the	DT
cord-347986-ds5hm731	144	7	hepatic	hepatic	JJ
cord-347986-ds5hm731	144	8	cytochrome	cytochrome	NN
cord-347986-ds5hm731	144	9	P-450	p-450	PRP
cord-347986-ds5hm731	144	10	isoenzyme	isoenzyme	NNS
cord-347986-ds5hm731	144	11	system	system	NN
cord-347986-ds5hm731	144	12	,	,	,
cord-347986-ds5hm731	144	13	suggesting	suggest	VBG
cord-347986-ds5hm731	144	14	it	-PRON-	PRP
cord-347986-ds5hm731	144	15	could	could	MD
cord-347986-ds5hm731	144	16	be	be	VB
cord-347986-ds5hm731	144	17	safely	safely	RB
cord-347986-ds5hm731	144	18	used	use	VBN
cord-347986-ds5hm731	144	19	with	with	IN
cord-347986-ds5hm731	144	20	ARVs	arv	NNS
cord-347986-ds5hm731	144	21	[	[	-LRB-
cord-347986-ds5hm731	144	22	21	21	CD
cord-347986-ds5hm731	144	23	]	]	-RRB-
cord-347986-ds5hm731	144	24	.	.	.
cord-347986-ds5hm731	145	1	There	there	EX
cord-347986-ds5hm731	145	2	is	be	VBZ
cord-347986-ds5hm731	145	3	no	no	DT
cord-347986-ds5hm731	145	4	evidence	evidence	NN
cord-347986-ds5hm731	145	5	of	of	IN
cord-347986-ds5hm731	145	6	genotoxicity	genotoxicity	NN
cord-347986-ds5hm731	145	7	,	,	,
cord-347986-ds5hm731	145	8	by	by	IN
cord-347986-ds5hm731	145	9	such	such	JJ
cord-347986-ds5hm731	145	10	standard	standard	JJ
cord-347986-ds5hm731	145	11	tests	test	NNS
cord-347986-ds5hm731	145	12	as	as	IN
cord-347986-ds5hm731	145	13	Ames	Ames	NNP
cord-347986-ds5hm731	145	14	.	.	.
cord-347986-ds5hm731	146	1	The	the	DT
cord-347986-ds5hm731	146	2	Global	Global	NNP
cord-347986-ds5hm731	146	3	Alliance	Alliance	NNP
cord-347986-ds5hm731	146	4	for	for	IN
cord-347986-ds5hm731	146	5	TB	TB	NNP
cord-347986-ds5hm731	146	6	Drug	Drug	NNP
cord-347986-ds5hm731	146	7	Development	Development	NNP
cord-347986-ds5hm731	146	8	,	,	,
cord-347986-ds5hm731	146	9	a	a	DT
cord-347986-ds5hm731	146	10	non	non	JJ
cord-347986-ds5hm731	146	11	-	-	JJ
cord-347986-ds5hm731	146	12	profit	profit	JJ
cord-347986-ds5hm731	146	13	,	,	,
cord-347986-ds5hm731	146	14	public	public	JJ
cord-347986-ds5hm731	146	15	-	-	HYPH
cord-347986-ds5hm731	146	16	private	private	JJ
cord-347986-ds5hm731	146	17	partnership	partnership	NN
cord-347986-ds5hm731	146	18	has	have	VBZ
cord-347986-ds5hm731	146	19	directed	direct	VBN
cord-347986-ds5hm731	146	20	and	and	CC
cord-347986-ds5hm731	146	21	funded	fund	VBN
cord-347986-ds5hm731	146	22	PA-824	pa-824	NN
cord-347986-ds5hm731	146	23	's	's	POS
cord-347986-ds5hm731	146	24	development	development	NN
cord-347986-ds5hm731	146	25	and	and	CC
cord-347986-ds5hm731	146	26	has	have	VBZ
cord-347986-ds5hm731	146	27	obtained	obtain	VBN
cord-347986-ds5hm731	146	28	exclusive	exclusive	JJ
cord-347986-ds5hm731	146	29	worldwide	worldwide	JJ
cord-347986-ds5hm731	146	30	rights	right	NNS
cord-347986-ds5hm731	146	31	to	to	IN
cord-347986-ds5hm731	146	32	PA-824	pa-824	NN
cord-347986-ds5hm731	146	33	and	and	CC
cord-347986-ds5hm731	146	34	its	-PRON-	PRP$
cord-347986-ds5hm731	146	35	derivatives	derivative	NNS
cord-347986-ds5hm731	146	36	,	,	,
cord-347986-ds5hm731	146	37	so	so	IN
cord-347986-ds5hm731	146	38	that	that	IN
cord-347986-ds5hm731	146	39	the	the	DT
cord-347986-ds5hm731	146	40	technology	technology	NN
cord-347986-ds5hm731	146	41	will	will	MD
cord-347986-ds5hm731	146	42	be	be	VB
cord-347986-ds5hm731	146	43	available	available	JJ
cord-347986-ds5hm731	146	44	royalty	royalty	NN
cord-347986-ds5hm731	146	45	free	free	JJ
cord-347986-ds5hm731	146	46	in	in	IN
cord-347986-ds5hm731	146	47	endemic	endemic	JJ
cord-347986-ds5hm731	146	48	countries	country	NNS
cord-347986-ds5hm731	146	49	.	.	.
cord-347986-ds5hm731	146	50	 	 	_SP
cord-347986-ds5hm731	147	1	Work	work	NN
cord-347986-ds5hm731	147	2	has	have	VBZ
cord-347986-ds5hm731	147	3	also	also	RB
cord-347986-ds5hm731	147	4	begun	begin	VBN
cord-347986-ds5hm731	147	5	on	on	IN
cord-347986-ds5hm731	147	6	second	second	JJ
cord-347986-ds5hm731	147	7	-	-	HYPH
cord-347986-ds5hm731	147	8	generation	generation	NN
cord-347986-ds5hm731	147	9	nitroimidazoles	nitroimidazoles	NNP
cord-347986-ds5hm731	147	10	.	.	.
cord-347986-ds5hm731	148	1	In	in	IN
cord-347986-ds5hm731	148	2	Japan	Japan	NNP
cord-347986-ds5hm731	148	3	,	,	,
cord-347986-ds5hm731	148	4	a	a	DT
cord-347986-ds5hm731	148	5	nitroimidazo	nitroimidazo	NNP
cord-347986-ds5hm731	148	6	-	-	HYPH
cord-347986-ds5hm731	148	7	oxazole	oxazole	NNP
cord-347986-ds5hm731	148	8	OPC-67683	OPC-67683	NNP
cord-347986-ds5hm731	148	9	,	,	,
cord-347986-ds5hm731	148	10	8	8	CD
cord-347986-ds5hm731	148	11	,	,	,
cord-347986-ds5hm731	148	12	has	have	VBZ
cord-347986-ds5hm731	148	13	entered	enter	VBN
cord-347986-ds5hm731	148	14	phase	phase	NN
cord-347986-ds5hm731	149	1	I	-PRON-	PRP
cord-347986-ds5hm731	149	2	clinical	clinical	JJ
cord-347986-ds5hm731	149	3	trials	trial	NNS
cord-347986-ds5hm731	149	4	and	and	CC
cord-347986-ds5hm731	149	5	a	a	DT
cord-347986-ds5hm731	149	6	backup	backup	JJ
cord-347986-ds5hm731	149	7	nitroimidazo	nitroimidazo	NNP
cord-347986-ds5hm731	149	8	-	-	HYPH
cord-347986-ds5hm731	149	9	oxazole	oxazole	NNP
cord-347986-ds5hm731	149	10	is	be	VBZ
cord-347986-ds5hm731	149	11	in	in	IN
cord-347986-ds5hm731	149	12	early	early	JJ
cord-347986-ds5hm731	149	13	development	development	NN
cord-347986-ds5hm731	149	14	.	.	.
cord-347986-ds5hm731	150	1	Preclinical	preclinical	JJ
cord-347986-ds5hm731	150	2	data	datum	NNS
cord-347986-ds5hm731	150	3	has	have	VBZ
cord-347986-ds5hm731	150	4	been	be	VBN
cord-347986-ds5hm731	150	5	encouraging	encourage	VBG
cord-347986-ds5hm731	150	6	so	so	RB
cord-347986-ds5hm731	150	7	far	far	RB
cord-347986-ds5hm731	150	8	[	[	-LRB-
cord-347986-ds5hm731	150	9	22	22	CD
cord-347986-ds5hm731	150	10	]	]	-RRB-
cord-347986-ds5hm731	150	11	.	.	.
cord-347986-ds5hm731	151	1	Second	second	JJ
cord-347986-ds5hm731	151	2	-	-	HYPH
cord-347986-ds5hm731	151	3	generation	generation	NN
cord-347986-ds5hm731	151	4	nitroimidazopyran	nitroimidazopyran	JJ
cord-347986-ds5hm731	151	5	analogs	analog	NNS
cord-347986-ds5hm731	151	6	with	with	IN
cord-347986-ds5hm731	151	7	greater	great	JJR
cord-347986-ds5hm731	151	8	in	in	IN
cord-347986-ds5hm731	151	9	vivo	vivo	NN
cord-347986-ds5hm731	151	10	potency	potency	NN
cord-347986-ds5hm731	151	11	in	in	IN
cord-347986-ds5hm731	151	12	animal	animal	NN
cord-347986-ds5hm731	151	13	models	model	NNS
cord-347986-ds5hm731	151	14	have	have	VBP
cord-347986-ds5hm731	151	15	also	also	RB
cord-347986-ds5hm731	151	16	been	be	VBN
cord-347986-ds5hm731	151	17	identified	identify	VBN
cord-347986-ds5hm731	151	18	.	.	.
cord-347986-ds5hm731	152	1	Sudoterb	Sudoterb	NNP
cord-347986-ds5hm731	152	2	belongs	belong	VBZ
cord-347986-ds5hm731	152	3	to	to	IN
cord-347986-ds5hm731	152	4	a	a	DT
cord-347986-ds5hm731	152	5	class	class	NN
cord-347986-ds5hm731	152	6	of	of	IN
cord-347986-ds5hm731	152	7	compounds	compound	NNS
cord-347986-ds5hm731	152	8	known	know	VBN
cord-347986-ds5hm731	152	9	as	as	IN
cord-347986-ds5hm731	152	10	pyrroles	pyrrole	NNS
cord-347986-ds5hm731	152	11	,	,	,
cord-347986-ds5hm731	152	12	which	which	WDT
cord-347986-ds5hm731	152	13	are	be	VBP
cord-347986-ds5hm731	152	14	plant	plant	NN
cord-347986-ds5hm731	152	15	alkaloids	alkaloid	NNS
cord-347986-ds5hm731	152	16	.	.	.
cord-347986-ds5hm731	153	1	Sudoterb	Sudoterb	NNP
cord-347986-ds5hm731	153	2	has	have	VBZ
cord-347986-ds5hm731	153	3	been	be	VBN
cord-347986-ds5hm731	153	4	reported	report	VBN
cord-347986-ds5hm731	153	5	to	to	TO
cord-347986-ds5hm731	153	6	have	have	VB
cord-347986-ds5hm731	153	7	potent	potent	JJ
cord-347986-ds5hm731	153	8	anti	anti	JJ
cord-347986-ds5hm731	153	9	-	-	JJ
cord-347986-ds5hm731	153	10	TB	tb	JJ
cord-347986-ds5hm731	153	11	activity	activity	NN
cord-347986-ds5hm731	153	12	in	in	IN
cord-347986-ds5hm731	153	13	vitro	vitro	FW
cord-347986-ds5hm731	153	14	and	and	CC
cord-347986-ds5hm731	153	15	in	in	IN
cord-347986-ds5hm731	153	16	vivo	vivo	NNP
cord-347986-ds5hm731	153	17	.	.	.
cord-347986-ds5hm731	154	1	In	in	IN
cord-347986-ds5hm731	154	2	vitro	vitro	FW
cord-347986-ds5hm731	154	3	,	,	,
cord-347986-ds5hm731	154	4	sudoterb	sudoterb	NNP
cord-347986-ds5hm731	154	5	has	have	VBZ
cord-347986-ds5hm731	154	6	bactericidal	bactericidal	JJ
cord-347986-ds5hm731	154	7	activity	activity	NN
cord-347986-ds5hm731	154	8	similar	similar	JJ
cord-347986-ds5hm731	154	9	to	to	IN
cord-347986-ds5hm731	154	10	isoniazid	isoniazid	NN
cord-347986-ds5hm731	154	11	and	and	CC
cord-347986-ds5hm731	154	12	is	be	VBZ
cord-347986-ds5hm731	154	13	synergistic	synergistic	JJ
cord-347986-ds5hm731	154	14	with	with	IN
cord-347986-ds5hm731	154	15	rifampin	rifampin	NN
cord-347986-ds5hm731	154	16	.	.	.
cord-347986-ds5hm731	155	1	The	the	DT
cord-347986-ds5hm731	155	2	combination	combination	NN
cord-347986-ds5hm731	155	3	of	of	IN
cord-347986-ds5hm731	155	4	sudoterb	sudoterb	NN
cord-347986-ds5hm731	155	5	with	with	IN
cord-347986-ds5hm731	155	6	isoniazid	isoniazid	NN
cord-347986-ds5hm731	155	7	,	,	,
cord-347986-ds5hm731	155	8	rifampin	rifampin	NN
cord-347986-ds5hm731	155	9	,	,	,
cord-347986-ds5hm731	155	10	and	and	CC
cord-347986-ds5hm731	155	11	pyrazinamide	pyrazinamide	NN
cord-347986-ds5hm731	155	12	led	lead	VBD
cord-347986-ds5hm731	155	13	to	to	TO
cord-347986-ds5hm731	155	14	complete	complete	VB
cord-347986-ds5hm731	155	15	sterilization	sterilization	NN
cord-347986-ds5hm731	155	16	of	of	IN
cord-347986-ds5hm731	155	17	both	both	CC
cord-347986-ds5hm731	155	18	sensitive	sensitive	JJ
cord-347986-ds5hm731	155	19	and	and	CC
cord-347986-ds5hm731	155	20	MDR	MDR	NNP
cord-347986-ds5hm731	155	21	-	-	HYPH
cord-347986-ds5hm731	155	22	TB	TB	NNP
cord-347986-ds5hm731	155	23	strains	strain	NNS
cord-347986-ds5hm731	155	24	in	in	IN
cord-347986-ds5hm731	155	25	mice	mouse	NNS
cord-347986-ds5hm731	155	26	within	within	IN
cord-347986-ds5hm731	155	27	two	two	CD
cord-347986-ds5hm731	155	28	months	month	NNS
cord-347986-ds5hm731	155	29	,	,	,
cord-347986-ds5hm731	155	30	and	and	CC
cord-347986-ds5hm731	155	31	in	in	IN
cord-347986-ds5hm731	155	32	combination	combination	NN
cord-347986-ds5hm731	155	33	with	with	IN
cord-347986-ds5hm731	155	34	rifampin	rifampin	NN
cord-347986-ds5hm731	155	35	and	and	CC
cord-347986-ds5hm731	155	36	pyrazinamide	pyrazinamide	NN
cord-347986-ds5hm731	155	37	,	,	,
cord-347986-ds5hm731	155	38	cured	cure	VBD
cord-347986-ds5hm731	155	39	TB	TB	NNP
cord-347986-ds5hm731	155	40	in	in	IN
cord-347986-ds5hm731	155	41	all	all	DT
cord-347986-ds5hm731	155	42	animals	animal	NNS
cord-347986-ds5hm731	155	43	after	after	IN
cord-347986-ds5hm731	155	44	three	three	CD
cord-347986-ds5hm731	155	45	months	month	NNS
cord-347986-ds5hm731	155	46	.	.	.
cord-347986-ds5hm731	156	1	Sudoterb	Sudoterb	NNP
cord-347986-ds5hm731	156	2	exhibits	exhibit	VBZ
cord-347986-ds5hm731	156	3	good	good	JJ
cord-347986-ds5hm731	156	4	oral	oral	JJ
cord-347986-ds5hm731	156	5	bioavailability	bioavailability	NN
cord-347986-ds5hm731	156	6	with	with	IN
cord-347986-ds5hm731	156	7	once	once	RB
cord-347986-ds5hm731	156	8	daily	daily	JJ
cord-347986-ds5hm731	156	9	dosing	dosing	NN
cord-347986-ds5hm731	156	10	.	.	.
cord-347986-ds5hm731	157	1	Phase	phase	NN
cord-347986-ds5hm731	158	1	I	-PRON-	PRP
cord-347986-ds5hm731	158	2	studies	study	NNS
cord-347986-ds5hm731	158	3	began	begin	VBD
cord-347986-ds5hm731	158	4	in	in	IN
cord-347986-ds5hm731	158	5	India	India	NNP
cord-347986-ds5hm731	158	6	in	in	IN
cord-347986-ds5hm731	158	7	2005	2005	CD
cord-347986-ds5hm731	158	8	[	[	-LRB-
cord-347986-ds5hm731	158	9	23	23	CD
cord-347986-ds5hm731	158	10	]	]	-RRB-
cord-347986-ds5hm731	158	11	.	.	.
cord-347986-ds5hm731	159	1	The	the	DT
cord-347986-ds5hm731	159	2	structure	structure	NN
cord-347986-ds5hm731	159	3	of	of	IN
cord-347986-ds5hm731	159	4	sudoterb	sudoterb	NN
cord-347986-ds5hm731	159	5	has	have	VBZ
cord-347986-ds5hm731	159	6	not	not	RB
cord-347986-ds5hm731	159	7	been	be	VBN
cord-347986-ds5hm731	159	8	released	release	VBN
cord-347986-ds5hm731	159	9	.	.	.
cord-347986-ds5hm731	160	1	Currently	currently	RB
cord-347986-ds5hm731	160	2	,	,	,
cord-347986-ds5hm731	160	3	BCG	BCG	NNP
cord-347986-ds5hm731	160	4	(	(	-LRB-
cord-347986-ds5hm731	160	5	Bacille	Bacille	NNP
cord-347986-ds5hm731	160	6	Calmette	Calmette	NNP
cord-347986-ds5hm731	160	7	-	-	HYPH
cord-347986-ds5hm731	160	8	Gue´rin	Gue´rin	NNP
cord-347986-ds5hm731	160	9	)	)	-RRB-
cord-347986-ds5hm731	160	10	is	be	VBZ
cord-347986-ds5hm731	160	11	the	the	DT
cord-347986-ds5hm731	160	12	only	only	RB
cord-347986-ds5hm731	160	13	licensed	license	VBN
cord-347986-ds5hm731	160	14	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	160	15	vaccine	vaccine	NN
cord-347986-ds5hm731	160	16	.	.	.
cord-347986-ds5hm731	161	1	It	-PRON-	PRP
cord-347986-ds5hm731	161	2	has	have	VBZ
cord-347986-ds5hm731	161	3	a	a	DT
cord-347986-ds5hm731	161	4	number	number	NN
cord-347986-ds5hm731	161	5	of	of	IN
cord-347986-ds5hm731	161	6	shortcomings	shortcoming	NNS
cord-347986-ds5hm731	161	7	,	,	,
cord-347986-ds5hm731	161	8	among	among	IN
cord-347986-ds5hm731	161	9	which	which	WDT
cord-347986-ds5hm731	161	10	is	be	VBZ
cord-347986-ds5hm731	161	11	a	a	DT
cord-347986-ds5hm731	161	12	relatively	relatively	RB
cord-347986-ds5hm731	161	13	short	short	JJ
cord-347986-ds5hm731	161	14	period	period	NN
cord-347986-ds5hm731	161	15	of	of	IN
cord-347986-ds5hm731	161	16	protection	protection	NN
cord-347986-ds5hm731	161	17	,	,	,
cord-347986-ds5hm731	161	18	and	and	CC
cord-347986-ds5hm731	161	19	poor	poor	JJ
cord-347986-ds5hm731	161	20	antibody	antibody	NN
cord-347986-ds5hm731	161	21	stimulation	stimulation	NN
cord-347986-ds5hm731	161	22	response	response	NN
cord-347986-ds5hm731	161	23	beyond	beyond	IN
cord-347986-ds5hm731	161	24	childhood	childhood	NN
cord-347986-ds5hm731	161	25	.	.	.
cord-347986-ds5hm731	162	1	Since	since	IN
cord-347986-ds5hm731	162	2	there	there	EX
cord-347986-ds5hm731	162	3	are	be	VBP
cord-347986-ds5hm731	162	4	clearly	clearly	RB
cord-347986-ds5hm731	162	5	many	many	JJ
cord-347986-ds5hm731	162	6	problems	problem	NNS
cord-347986-ds5hm731	162	7	with	with	IN
cord-347986-ds5hm731	162	8	treating	treat	VBG
cord-347986-ds5hm731	162	9	TB	TB	NNP
cord-347986-ds5hm731	162	10	at	at	IN
cord-347986-ds5hm731	162	11	this	this	DT
cord-347986-ds5hm731	162	12	point	point	NN
cord-347986-ds5hm731	162	13	,	,	,
cord-347986-ds5hm731	162	14	a	a	DT
cord-347986-ds5hm731	162	15	lot	lot	NN
cord-347986-ds5hm731	162	16	of	of	IN
cord-347986-ds5hm731	162	17	effort	effort	NN
cord-347986-ds5hm731	162	18	and	and	CC
cord-347986-ds5hm731	162	19	money	money	NN
cord-347986-ds5hm731	162	20	has	have	VBZ
cord-347986-ds5hm731	162	21	been	be	VBN
cord-347986-ds5hm731	162	22	focused	focus	VBN
cord-347986-ds5hm731	162	23	on	on	IN
cord-347986-ds5hm731	162	24	creation	creation	NN
cord-347986-ds5hm731	162	25	of	of	IN
cord-347986-ds5hm731	162	26	a	a	DT
cord-347986-ds5hm731	162	27	vaccine	vaccine	NN
cord-347986-ds5hm731	162	28	,	,	,
cord-347986-ds5hm731	162	29	as	as	IN
cord-347986-ds5hm731	162	30	a	a	DT
cord-347986-ds5hm731	162	31	means	means	NN
cord-347986-ds5hm731	162	32	of	of	IN
cord-347986-ds5hm731	162	33	preventing	prevent	VBG
cord-347986-ds5hm731	162	34	future	future	JJ
cord-347986-ds5hm731	162	35	infections	infection	NNS
cord-347986-ds5hm731	162	36	in	in	IN
cord-347986-ds5hm731	162	37	those	those	DT
cord-347986-ds5hm731	162	38	at	at	IN
cord-347986-ds5hm731	162	39	highest	high	JJS
cord-347986-ds5hm731	162	40	risk	risk	NN
cord-347986-ds5hm731	162	41	and	and	CC
cord-347986-ds5hm731	162	42	putting	put	VBG
cord-347986-ds5hm731	162	43	a	a	DT
cord-347986-ds5hm731	162	44	cap	cap	NN
cord-347986-ds5hm731	162	45	on	on	IN
cord-347986-ds5hm731	162	46	the	the	DT
cord-347986-ds5hm731	162	47	ever	ever	RB
cord-347986-ds5hm731	162	48	increasing	increase	VBG
cord-347986-ds5hm731	162	49	TB	TB	NNP
cord-347986-ds5hm731	162	50	epidemic	epidemic	NN
cord-347986-ds5hm731	162	51	.	.	.
cord-347986-ds5hm731	163	1	Unfortunately	unfortunately	RB
cord-347986-ds5hm731	163	2	,	,	,
cord-347986-ds5hm731	163	3	it	-PRON-	PRP
cord-347986-ds5hm731	163	4	appears	appear	VBZ
cord-347986-ds5hm731	163	5	the	the	DT
cord-347986-ds5hm731	163	6	obstacles	obstacle	NNS
cord-347986-ds5hm731	163	7	in	in	IN
cord-347986-ds5hm731	163	8	the	the	DT
cord-347986-ds5hm731	163	9	development	development	NN
cord-347986-ds5hm731	163	10	of	of	IN
cord-347986-ds5hm731	163	11	such	such	PDT
cord-347986-ds5hm731	163	12	a	a	DT
cord-347986-ds5hm731	163	13	vaccine	vaccine	NN
cord-347986-ds5hm731	163	14	are	be	VBP
cord-347986-ds5hm731	163	15	no	no	RB
cord-347986-ds5hm731	163	16	less	less	RBR
cord-347986-ds5hm731	163	17	challenging	challenging	JJ
cord-347986-ds5hm731	163	18	than	than	IN
cord-347986-ds5hm731	163	19	those	those	DT
cord-347986-ds5hm731	163	20	hindering	hinder	VBG
cord-347986-ds5hm731	163	21	drug	drug	NN
cord-347986-ds5hm731	163	22	development	development	NN
cord-347986-ds5hm731	163	23	.	.	.
cord-347986-ds5hm731	164	1	It	-PRON-	PRP
cord-347986-ds5hm731	164	2	is	be	VBZ
cord-347986-ds5hm731	164	3	well	well	RB
cord-347986-ds5hm731	164	4	know	know	VB
cord-347986-ds5hm731	164	5	that	that	IN
cord-347986-ds5hm731	164	6	BCG	BCG	NNP
cord-347986-ds5hm731	164	7	varies	vary	VBZ
cord-347986-ds5hm731	164	8	in	in	IN
cord-347986-ds5hm731	164	9	effectiveness	effectiveness	NN
cord-347986-ds5hm731	164	10	among	among	IN
cord-347986-ds5hm731	164	11	those	those	DT
cord-347986-ds5hm731	164	12	who	who	WP
cord-347986-ds5hm731	164	13	receive	receive	VBP
cord-347986-ds5hm731	164	14	it	-PRON-	PRP
cord-347986-ds5hm731	164	15	.	.	.
cord-347986-ds5hm731	165	1	This	this	DT
cord-347986-ds5hm731	165	2	has	have	VBZ
cord-347986-ds5hm731	165	3	previously	previously	RB
cord-347986-ds5hm731	165	4	been	be	VBN
cord-347986-ds5hm731	165	5	attributed	attribute	VBN
cord-347986-ds5hm731	165	6	to	to	IN
cord-347986-ds5hm731	165	7	different	different	JJ
cord-347986-ds5hm731	165	8	environmental	environmental	JJ
cord-347986-ds5hm731	165	9	factors	factor	NNS
cord-347986-ds5hm731	165	10	or	or	CC
cord-347986-ds5hm731	165	11	differences	difference	NNS
cord-347986-ds5hm731	165	12	in	in	IN
cord-347986-ds5hm731	165	13	the	the	DT
cord-347986-ds5hm731	165	14	BCG	BCG	NNP
cord-347986-ds5hm731	165	15	strains	strain	NNS
cord-347986-ds5hm731	165	16	used	use	VBN
cord-347986-ds5hm731	165	17	to	to	TO
cord-347986-ds5hm731	165	18	create	create	VB
cord-347986-ds5hm731	165	19	the	the	DT
cord-347986-ds5hm731	165	20	vaccine	vaccine	NN
cord-347986-ds5hm731	165	21	.	.	.
cord-347986-ds5hm731	166	1	However	however	RB
cord-347986-ds5hm731	166	2	,	,	,
cord-347986-ds5hm731	166	3	a	a	DT
cord-347986-ds5hm731	166	4	recent	recent	JJ
cord-347986-ds5hm731	166	5	gene	gene	NN
cord-347986-ds5hm731	166	6	analysis	analysis	NN
cord-347986-ds5hm731	166	7	has	have	VBZ
cord-347986-ds5hm731	166	8	found	find	VBN
cord-347986-ds5hm731	166	9	that	that	IN
cord-347986-ds5hm731	166	10	M.	M.	NNP
cord-347986-ds5hm731	166	11	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	166	12	is	be	VBZ
cord-347986-ds5hm731	166	13	genetically	genetically	RB
cord-347986-ds5hm731	166	14	distinct	distinct	JJ
cord-347986-ds5hm731	166	15	in	in	IN
cord-347986-ds5hm731	166	16	different	different	JJ
cord-347986-ds5hm731	166	17	parts	part	NNS
cord-347986-ds5hm731	166	18	of	of	IN
cord-347986-ds5hm731	166	19	the	the	DT
cord-347986-ds5hm731	166	20	world	world	NN
cord-347986-ds5hm731	166	21	and	and	CC
cord-347986-ds5hm731	166	22	has	have	VBZ
cord-347986-ds5hm731	166	23	evolved	evolve	VBN
cord-347986-ds5hm731	166	24	into	into	IN
cord-347986-ds5hm731	166	25	6	6	CD
cord-347986-ds5hm731	166	26	different	different	JJ
cord-347986-ds5hm731	166	27	lineages	lineage	NNS
cord-347986-ds5hm731	166	28	:	:	:
cord-347986-ds5hm731	166	29	East	east	JJ
cord-347986-ds5hm731	166	30	-	-	HYPH
cord-347986-ds5hm731	166	31	African	african	JJ
cord-347986-ds5hm731	166	32	-	-	HYPH
cord-347986-ds5hm731	166	33	Indian	indian	JJ
cord-347986-ds5hm731	166	34	,	,	,
cord-347986-ds5hm731	166	35	East	east	JJ
cord-347986-ds5hm731	166	36	-	-	HYPH
cord-347986-ds5hm731	166	37	Asian	Asian	NNP
cord-347986-ds5hm731	166	38	,	,	,
cord-347986-ds5hm731	166	39	Euro	Euro	NNP
cord-347986-ds5hm731	166	40	-	-	HYPH
cord-347986-ds5hm731	166	41	American	American	NNP
cord-347986-ds5hm731	166	42	,	,	,
cord-347986-ds5hm731	166	43	Indo	Indo	NNP
cord-347986-ds5hm731	166	44	-	-	HYPH
cord-347986-ds5hm731	166	45	Oceanic	Oceanic	NNP
cord-347986-ds5hm731	166	46	,	,	,
cord-347986-ds5hm731	166	47	and	and	CC
cord-347986-ds5hm731	166	48	two	two	CD
cord-347986-ds5hm731	166	49	West	west	JJ
cord-347986-ds5hm731	166	50	-	-	HYPH
cord-347986-ds5hm731	166	51	African	African	NNP
cord-347986-ds5hm731	166	52	.	.	.
cord-347986-ds5hm731	167	1	These	these	DT
cord-347986-ds5hm731	167	2	strains	strain	NNS
cord-347986-ds5hm731	167	3	appear	appear	VBP
cord-347986-ds5hm731	167	4	to	to	TO
cord-347986-ds5hm731	167	5	have	have	VB
cord-347986-ds5hm731	167	6	adapted	adapt	VBN
cord-347986-ds5hm731	167	7	over	over	IN
cord-347986-ds5hm731	167	8	time	time	NN
cord-347986-ds5hm731	167	9	to	to	IN
cord-347986-ds5hm731	167	10	specific	specific	JJ
cord-347986-ds5hm731	167	11	human	human	JJ
cord-347986-ds5hm731	167	12	populations	population	NNS
cord-347986-ds5hm731	167	13	,	,	,
cord-347986-ds5hm731	167	14	which	which	WDT
cord-347986-ds5hm731	167	15	suggest	suggest	VBP
cord-347986-ds5hm731	167	16	separate	separate	JJ
cord-347986-ds5hm731	167	17	,	,	,
cord-347986-ds5hm731	167	18	wholly	wholly	RB
cord-347986-ds5hm731	167	19	different	different	JJ
cord-347986-ds5hm731	167	20	vaccines	vaccine	NNS
cord-347986-ds5hm731	167	21	might	may	MD
cord-347986-ds5hm731	167	22	be	be	VB
cord-347986-ds5hm731	167	23	required	require	VBN
cord-347986-ds5hm731	167	24	for	for	IN
cord-347986-ds5hm731	167	25	each	each	DT
cord-347986-ds5hm731	167	26	region	region	NN
cord-347986-ds5hm731	167	27	[	[	-LRB-
cord-347986-ds5hm731	167	28	24	24	CD
cord-347986-ds5hm731	167	29	]	]	-RRB-
cord-347986-ds5hm731	167	30	.	.	.
cord-347986-ds5hm731	168	1	Those	those	DT
cord-347986-ds5hm731	168	2	who	who	WP
cord-347986-ds5hm731	168	3	receive	receive	VBP
cord-347986-ds5hm731	168	4	an	an	DT
cord-347986-ds5hm731	168	5	effective	effective	JJ
cord-347986-ds5hm731	168	6	vaccine	vaccine	NN
cord-347986-ds5hm731	168	7	may	may	MD
cord-347986-ds5hm731	168	8	still	still	RB
cord-347986-ds5hm731	168	9	not	not	RB
cord-347986-ds5hm731	168	10	develop	develop	VB
cord-347986-ds5hm731	168	11	adequate	adequate	JJ
cord-347986-ds5hm731	168	12	protection	protection	NN
cord-347986-ds5hm731	168	13	.	.	.
cord-347986-ds5hm731	169	1	BCG	BCG	NNP
cord-347986-ds5hm731	169	2	is	be	VBZ
cord-347986-ds5hm731	169	3	known	know	VBN
cord-347986-ds5hm731	169	4	to	to	TO
cord-347986-ds5hm731	169	5	stimulate	stimulate	VB
cord-347986-ds5hm731	169	6	Th1	th1	NN
cord-347986-ds5hm731	169	7	immune	immune	JJ
cord-347986-ds5hm731	169	8	cells	cell	NNS
cord-347986-ds5hm731	169	9	,	,	,
cord-347986-ds5hm731	169	10	which	which	WDT
cord-347986-ds5hm731	169	11	leads	lead	VBZ
cord-347986-ds5hm731	169	12	to	to	IN
cord-347986-ds5hm731	169	13	the	the	DT
cord-347986-ds5hm731	169	14	development	development	NN
cord-347986-ds5hm731	169	15	of	of	IN
cord-347986-ds5hm731	169	16	protective	protective	JJ
cord-347986-ds5hm731	169	17	antibody	antibody	NN
cord-347986-ds5hm731	169	18	and	and	CC
cord-347986-ds5hm731	169	19	drives	drive	VBZ
cord-347986-ds5hm731	169	20	M.	M.	NNP
cord-347986-ds5hm731	169	21	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	169	22	into	into	IN
cord-347986-ds5hm731	169	23	latency	latency	NN
cord-347986-ds5hm731	169	24	in	in	IN
cord-347986-ds5hm731	169	25	the	the	DT
cord-347986-ds5hm731	169	26	body	body	NN
cord-347986-ds5hm731	169	27	.	.	.
cord-347986-ds5hm731	170	1	In	in	IN
cord-347986-ds5hm731	170	2	many	many	JJ
cord-347986-ds5hm731	170	3	areas	area	NNS
cord-347986-ds5hm731	170	4	of	of	IN
cord-347986-ds5hm731	170	5	the	the	DT
cord-347986-ds5hm731	170	6	developing	develop	VBG
cord-347986-ds5hm731	170	7	world	world	NN
cord-347986-ds5hm731	170	8	,	,	,
cord-347986-ds5hm731	170	9	parasitic	parasitic	JJ
cord-347986-ds5hm731	170	10	helminthic	helminthic	JJ
cord-347986-ds5hm731	170	11	infections	infection	NNS
cord-347986-ds5hm731	170	12	are	be	VBP
cord-347986-ds5hm731	170	13	extremely	extremely	RB
cord-347986-ds5hm731	170	14	common	common	JJ
cord-347986-ds5hm731	170	15	.	.	.
cord-347986-ds5hm731	171	1	Parasites	parasite	NNS
cord-347986-ds5hm731	171	2	stimulate	stimulate	VBP
cord-347986-ds5hm731	171	3	a	a	DT
cord-347986-ds5hm731	171	4	Th2	th2	CD
cord-347986-ds5hm731	171	5	immune	immune	JJ
cord-347986-ds5hm731	171	6	cell	cell	NN
cord-347986-ds5hm731	171	7	response	response	NN
cord-347986-ds5hm731	171	8	,	,	,
cord-347986-ds5hm731	171	9	usually	usually	RB
cord-347986-ds5hm731	171	10	associated	associate	VBN
cord-347986-ds5hm731	171	11	with	with	IN
cord-347986-ds5hm731	171	12	an	an	DT
cord-347986-ds5hm731	171	13	allergic	allergic	JJ
cord-347986-ds5hm731	171	14	response	response	NN
cord-347986-ds5hm731	171	15	.	.	.
cord-347986-ds5hm731	172	1	This	this	DT
cord-347986-ds5hm731	172	2	increase	increase	NN
cord-347986-ds5hm731	172	3	in	in	IN
cord-347986-ds5hm731	172	4	background	background	NN
cord-347986-ds5hm731	172	5	Th2	th2	CD
cord-347986-ds5hm731	172	6	response	response	NN
cord-347986-ds5hm731	172	7	is	be	VBZ
cord-347986-ds5hm731	172	8	antagonistic	antagonistic	JJ
cord-347986-ds5hm731	172	9	to	to	IN
cord-347986-ds5hm731	172	10	the	the	DT
cord-347986-ds5hm731	172	11	Th1	Th1	NNP
cord-347986-ds5hm731	172	12	cell	cell	NN
cord-347986-ds5hm731	172	13	response	response	NN
cord-347986-ds5hm731	172	14	,	,	,
cord-347986-ds5hm731	172	15	and	and	CC
cord-347986-ds5hm731	172	16	,	,	,
cord-347986-ds5hm731	172	17	in	in	IN
cord-347986-ds5hm731	172	18	theory	theory	NN
cord-347986-ds5hm731	172	19	,	,	,
cord-347986-ds5hm731	172	20	will	will	MD
cord-347986-ds5hm731	172	21	blunt	blunt	VB
cord-347986-ds5hm731	172	22	or	or	CC
cord-347986-ds5hm731	172	23	lead	lead	VB
cord-347986-ds5hm731	172	24	to	to	IN
cord-347986-ds5hm731	172	25	an	an	DT
cord-347986-ds5hm731	172	26	inadequate	inadequate	JJ
cord-347986-ds5hm731	172	27	immune	immune	NN
cord-347986-ds5hm731	172	28	,	,	,
cord-347986-ds5hm731	172	29	as	as	RB
cord-347986-ds5hm731	172	30	well	well	RB
cord-347986-ds5hm731	172	31	as	as	IN
cord-347986-ds5hm731	172	32	cause	cause	NN
cord-347986-ds5hm731	172	33	impaired	impaired	JJ
cord-347986-ds5hm731	172	34	bactericidal	bactericidal	JJ
cord-347986-ds5hm731	172	35	activity	activity	NN
cord-347986-ds5hm731	172	36	[	[	-LRB-
cord-347986-ds5hm731	172	37	25	25	CD
cord-347986-ds5hm731	172	38	]	]	-RRB-
cord-347986-ds5hm731	172	39	.	.	.
cord-347986-ds5hm731	173	1	Nevertheless	nevertheless	RB
cord-347986-ds5hm731	173	2	,	,	,
cord-347986-ds5hm731	173	3	work	work	NN
cord-347986-ds5hm731	173	4	continues	continue	VBZ
cord-347986-ds5hm731	173	5	on	on	IN
cord-347986-ds5hm731	173	6	a	a	DT
cord-347986-ds5hm731	173	7	vaccine	vaccine	NN
cord-347986-ds5hm731	173	8	.	.	.
cord-347986-ds5hm731	174	1	A	a	DT
cord-347986-ds5hm731	174	2	leading	lead	VBG
cord-347986-ds5hm731	174	3	candidate	candidate	NN
cord-347986-ds5hm731	174	4	,	,	,
cord-347986-ds5hm731	174	5	MVA85A	MVA85A	NNP
cord-347986-ds5hm731	174	6	,	,	,
cord-347986-ds5hm731	174	7	utilizes	utilize	VBZ
cord-347986-ds5hm731	174	8	a	a	DT
cord-347986-ds5hm731	174	9	recombinant	recombinant	JJ
cord-347986-ds5hm731	174	10	vaccinia	vaccinia	NN
cord-347986-ds5hm731	174	11	virus	virus	NN
cord-347986-ds5hm731	174	12	Ankara	Ankara	NNP
cord-347986-ds5hm731	174	13	(	(	-LRB-
cord-347986-ds5hm731	174	14	MVA	MVA	NNP
cord-347986-ds5hm731	174	15	)	)	-RRB-
cord-347986-ds5hm731	174	16	expressing	express	VBG
cord-347986-ds5hm731	174	17	antigen	antigen	NNP
cord-347986-ds5hm731	174	18	85A.	85a.	CD
cord-347986-ds5hm731	174	19	MVA85A	MVA85A	NNP
cord-347986-ds5hm731	174	20	completed	complete	VBD
cord-347986-ds5hm731	174	21	a	a	DT
cord-347986-ds5hm731	174	22	Phase	phase	NN
cord-347986-ds5hm731	175	1	I	-PRON-	PRP
cord-347986-ds5hm731	175	2	clinical	clinical	JJ
cord-347986-ds5hm731	175	3	trial	trial	NN
cord-347986-ds5hm731	175	4	in	in	IN
cord-347986-ds5hm731	175	5	the	the	DT
cord-347986-ds5hm731	175	6	United	United	NNP
cord-347986-ds5hm731	175	7	Kingdom	Kingdom	NNP
cord-347986-ds5hm731	175	8	in	in	IN
cord-347986-ds5hm731	175	9	2004	2004	CD
cord-347986-ds5hm731	175	10	.	.	.
cord-347986-ds5hm731	176	1	When	when	WRB
cord-347986-ds5hm731	176	2	given	give	VBN
cord-347986-ds5hm731	176	3	with	with	IN
cord-347986-ds5hm731	176	4	BCG	BCG	NNP
cord-347986-ds5hm731	176	5	,	,	,
cord-347986-ds5hm731	176	6	Th1	th1	NN
cord-347986-ds5hm731	176	7	levels	level	NNS
cord-347986-ds5hm731	176	8	were	be	VBD
cord-347986-ds5hm731	176	9	upto	upto	RB
cord-347986-ds5hm731	176	10	30-fold	30-fold	RB
cord-347986-ds5hm731	176	11	higher	high	JJR
cord-347986-ds5hm731	176	12	than	than	IN
cord-347986-ds5hm731	176	13	groups	group	NNS
cord-347986-ds5hm731	176	14	given	give	VBN
cord-347986-ds5hm731	176	15	MVA85A	MVA85A	NNP
cord-347986-ds5hm731	176	16	or	or	CC
cord-347986-ds5hm731	176	17	BCG	BCG	NNP
cord-347986-ds5hm731	176	18	alone	alone	RB
cord-347986-ds5hm731	176	19	[	[	-LRB-
cord-347986-ds5hm731	176	20	26	26	CD
cord-347986-ds5hm731	176	21	]	]	-RRB-
cord-347986-ds5hm731	176	22	.	.	.
cord-347986-ds5hm731	177	1	Further	further	JJ
cord-347986-ds5hm731	177	2	clinical	clinical	JJ
cord-347986-ds5hm731	177	3	trials	trial	NNS
cord-347986-ds5hm731	177	4	in	in	IN
cord-347986-ds5hm731	177	5	the	the	DT
cord-347986-ds5hm731	177	6	United	United	NNP
cord-347986-ds5hm731	177	7	Kingdom	Kingdom	NNP
cord-347986-ds5hm731	177	8	and	and	CC
cord-347986-ds5hm731	177	9	Gambia	Gambia	NNP
cord-347986-ds5hm731	177	10	are	be	VBP
cord-347986-ds5hm731	177	11	in	in	IN
cord-347986-ds5hm731	177	12	progress	progress	NN
cord-347986-ds5hm731	177	13	.	.	.
cord-347986-ds5hm731	178	1	Another	another	DT
cord-347986-ds5hm731	178	2	vaccine	vaccine	NN
cord-347986-ds5hm731	178	3	,	,	,
cord-347986-ds5hm731	178	4	Mtb72F	Mtb72F	NNP
cord-347986-ds5hm731	178	5	/	/	SYM
cord-347986-ds5hm731	178	6	AS02A	as02a	JJ
cord-347986-ds5hm731	178	7	consisting	consist	VBG
cord-347986-ds5hm731	178	8	of	of	IN
cord-347986-ds5hm731	178	9	a	a	DT
cord-347986-ds5hm731	178	10	recombinant	recombinant	JJ
cord-347986-ds5hm731	178	11	fusion	fusion	NN
cord-347986-ds5hm731	178	12	protein	protein	NN
cord-347986-ds5hm731	178	13	(	(	-LRB-
cord-347986-ds5hm731	178	14	Mtb72F	Mtb72F	NNP
cord-347986-ds5hm731	178	15	)	)	-RRB-
cord-347986-ds5hm731	178	16	formulated	formulate	VBN
cord-347986-ds5hm731	178	17	in	in	IN
cord-347986-ds5hm731	178	18	a	a	DT
cord-347986-ds5hm731	178	19	proprietary	proprietary	JJ
cord-347986-ds5hm731	178	20	adjuvant	adjuvant	NN
cord-347986-ds5hm731	178	21	system	system	NN
cord-347986-ds5hm731	178	22	(	(	-LRB-
cord-347986-ds5hm731	178	23	AS02A	as02a	NN
cord-347986-ds5hm731	178	24	)	)	-RRB-
cord-347986-ds5hm731	178	25	has	have	VBZ
cord-347986-ds5hm731	178	26	shown	show	VBN
cord-347986-ds5hm731	178	27	promising	promising	JJ
cord-347986-ds5hm731	178	28	results	result	NNS
cord-347986-ds5hm731	178	29	in	in	IN
cord-347986-ds5hm731	178	30	preclinical	preclinical	JJ
cord-347986-ds5hm731	178	31	studies	study	NNS
cord-347986-ds5hm731	178	32	to	to	TO
cord-347986-ds5hm731	178	33	induce	induce	VB
cord-347986-ds5hm731	178	34	strong	strong	JJ
cord-347986-ds5hm731	178	35	,	,	,
cord-347986-ds5hm731	178	36	long	long	RB
cord-347986-ds5hm731	178	37	lasting	last	VBG
cord-347986-ds5hm731	178	38	cellular	cellular	JJ
cord-347986-ds5hm731	178	39	and	and	CC
cord-347986-ds5hm731	178	40	humoral	humoral	JJ
cord-347986-ds5hm731	178	41	immune	immune	JJ
cord-347986-ds5hm731	178	42	responses	response	NNS
cord-347986-ds5hm731	178	43	.	.	.
cord-347986-ds5hm731	179	1	In	in	IN
cord-347986-ds5hm731	179	2	addition	addition	NN
cord-347986-ds5hm731	179	3	,	,	,
cord-347986-ds5hm731	179	4	the	the	DT
cord-347986-ds5hm731	179	5	vaccine	vaccine	NN
cord-347986-ds5hm731	179	6	has	have	VBZ
cord-347986-ds5hm731	179	7	shown	show	VBN
cord-347986-ds5hm731	179	8	a	a	DT
cord-347986-ds5hm731	179	9	good	good	JJ
cord-347986-ds5hm731	179	10	safety	safety	NN
cord-347986-ds5hm731	179	11	and	and	CC
cord-347986-ds5hm731	179	12	immunogenicity	immunogenicity	NN
cord-347986-ds5hm731	179	13	profile	profile	NN
cord-347986-ds5hm731	179	14	in	in	IN
cord-347986-ds5hm731	179	15	Phase	phase	NN
cord-347986-ds5hm731	179	16	I	-PRON-	PRP
cord-347986-ds5hm731	179	17	trials	trial	NNS
cord-347986-ds5hm731	179	18	.	.	.
cord-347986-ds5hm731	180	1	Phase	phase	NN
cord-347986-ds5hm731	180	2	II	ii	CD
cord-347986-ds5hm731	180	3	trials	trial	NNS
cord-347986-ds5hm731	180	4	are	be	VBP
cord-347986-ds5hm731	180	5	planned	plan	VBN
cord-347986-ds5hm731	180	6	to	to	IN
cord-347986-ds5hm731	180	7	being	be	VBG
cord-347986-ds5hm731	180	8	shortly	shortly	RB
cord-347986-ds5hm731	180	9	[	[	-LRB-
cord-347986-ds5hm731	180	10	27	27	CD
cord-347986-ds5hm731	180	11	]	]	-RRB-
cord-347986-ds5hm731	180	12	.	.	.
cord-347986-ds5hm731	181	1	Even	even	RB
cord-347986-ds5hm731	181	2	with	with	IN
cord-347986-ds5hm731	181	3	concerns	concern	NNS
cord-347986-ds5hm731	181	4	with	with	IN
cord-347986-ds5hm731	181	5	the	the	DT
cord-347986-ds5hm731	181	6	potential	potential	JJ
cord-347986-ds5hm731	181	7	efficacy	efficacy	NN
cord-347986-ds5hm731	181	8	of	of	IN
cord-347986-ds5hm731	181	9	a	a	DT
cord-347986-ds5hm731	181	10	vaccine	vaccine	NN
cord-347986-ds5hm731	181	11	,	,	,
cord-347986-ds5hm731	181	12	there	there	EX
cord-347986-ds5hm731	181	13	may	may	MD
cord-347986-ds5hm731	181	14	still	still	RB
cord-347986-ds5hm731	181	15	be	be	VB
cord-347986-ds5hm731	181	16	a	a	DT
cord-347986-ds5hm731	181	17	role	role	NN
cord-347986-ds5hm731	181	18	for	for	IN
cord-347986-ds5hm731	181	19	its	-PRON-	PRP$
cord-347986-ds5hm731	181	20	use	use	NN
cord-347986-ds5hm731	181	21	.	.	.
cord-347986-ds5hm731	182	1	Combining	combine	VBG
cord-347986-ds5hm731	182	2	the	the	DT
cord-347986-ds5hm731	182	3	use	use	NN
cord-347986-ds5hm731	182	4	of	of	IN
cord-347986-ds5hm731	182	5	a	a	DT
cord-347986-ds5hm731	182	6	vaccine	vaccine	NN
cord-347986-ds5hm731	182	7	with	with	IN
cord-347986-ds5hm731	182	8	antituberculosis	antituberculosis	NN
cord-347986-ds5hm731	182	9	drugs	drug	NNS
cord-347986-ds5hm731	182	10	seems	seem	VBZ
cord-347986-ds5hm731	182	11	to	to	TO
cord-347986-ds5hm731	182	12	augment	augment	VB
cord-347986-ds5hm731	182	13	the	the	DT
cord-347986-ds5hm731	182	14	bactericidal	bactericidal	JJ
cord-347986-ds5hm731	182	15	activity	activity	NN
cord-347986-ds5hm731	182	16	of	of	IN
cord-347986-ds5hm731	182	17	the	the	DT
cord-347986-ds5hm731	182	18	drugs	drug	NNS
cord-347986-ds5hm731	182	19	,	,	,
cord-347986-ds5hm731	182	20	particularly	particularly	RB
cord-347986-ds5hm731	182	21	with	with	IN
cord-347986-ds5hm731	182	22	regard	regard	NN
cord-347986-ds5hm731	182	23	to	to	IN
cord-347986-ds5hm731	182	24	the	the	DT
cord-347986-ds5hm731	182	25	slowgrowing	slowgrowe	VBG
cord-347986-ds5hm731	182	26	mycobacteria	mycobacterium	NNS
cord-347986-ds5hm731	182	27	[	[	-LRB-
cord-347986-ds5hm731	182	28	21	21	CD
cord-347986-ds5hm731	182	29	]	]	-RRB-
cord-347986-ds5hm731	182	30	.	.	.
cord-347986-ds5hm731	183	1	We	-PRON-	PRP
cord-347986-ds5hm731	183	2	are	be	VBP
cord-347986-ds5hm731	183	3	still	still	RB
cord-347986-ds5hm731	183	4	years	year	NNS
cord-347986-ds5hm731	183	5	away	away	RB
cord-347986-ds5hm731	183	6	from	from	IN
cord-347986-ds5hm731	183	7	actually	actually	RB
cord-347986-ds5hm731	183	8	seeing	see	VBG
cord-347986-ds5hm731	183	9	any	any	DT
cord-347986-ds5hm731	183	10	of	of	IN
cord-347986-ds5hm731	183	11	these	these	DT
cord-347986-ds5hm731	183	12	developments	development	NNS
cord-347986-ds5hm731	183	13	in	in	IN
cord-347986-ds5hm731	183	14	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	183	15	treatment	treatment	NN
cord-347986-ds5hm731	183	16	actually	actually	RB
cord-347986-ds5hm731	183	17	enter	enter	VBP
cord-347986-ds5hm731	183	18	clinical	clinical	JJ
cord-347986-ds5hm731	183	19	practice	practice	NN
cord-347986-ds5hm731	183	20	.	.	.
cord-347986-ds5hm731	184	1	But	but	CC
cord-347986-ds5hm731	184	2	if	if	IN
cord-347986-ds5hm731	184	3	their	-PRON-	PRP$
cord-347986-ds5hm731	184	4	full	full	JJ
cord-347986-ds5hm731	184	5	potential	potential	NN
cord-347986-ds5hm731	184	6	is	be	VBZ
cord-347986-ds5hm731	184	7	achieved	achieve	VBN
cord-347986-ds5hm731	184	8	,	,	,
cord-347986-ds5hm731	184	9	then	then	RB
cord-347986-ds5hm731	184	10	it	-PRON-	PRP
cord-347986-ds5hm731	184	11	is	be	VBZ
cord-347986-ds5hm731	184	12	likely	likely	JJ
cord-347986-ds5hm731	184	13	that	that	IN
cord-347986-ds5hm731	184	14	none	none	NN
cord-347986-ds5hm731	184	15	of	of	IN
cord-347986-ds5hm731	184	16	the	the	DT
cord-347986-ds5hm731	184	17	current	current	JJ
cord-347986-ds5hm731	184	18	first	first	JJ
cord-347986-ds5hm731	184	19	-	-	HYPH
cord-347986-ds5hm731	184	20	line	line	NN
cord-347986-ds5hm731	184	21	drugs	drug	NNS
cord-347986-ds5hm731	184	22	will	will	MD
cord-347986-ds5hm731	184	23	be	be	VB
cord-347986-ds5hm731	184	24	part	part	NN
cord-347986-ds5hm731	184	25	of	of	IN
cord-347986-ds5hm731	184	26	the	the	DT
cord-347986-ds5hm731	184	27	new	new	JJ
cord-347986-ds5hm731	184	28	,	,	,
cord-347986-ds5hm731	184	29	optimized	optimize	VBN
cord-347986-ds5hm731	184	30	regimen	regimen	NN
cord-347986-ds5hm731	184	31	,	,	,
cord-347986-ds5hm731	184	32	which	which	WDT
cord-347986-ds5hm731	184	33	should	should	MD
cord-347986-ds5hm731	184	34	finally	finally	RB
cord-347986-ds5hm731	184	35	begin	begin	VB
cord-347986-ds5hm731	184	36	to	to	TO
cord-347986-ds5hm731	184	37	decrease	decrease	VB
cord-347986-ds5hm731	184	38	both	both	CC
cord-347986-ds5hm731	184	39	the	the	DT
cord-347986-ds5hm731	184	40	incidence	incidence	NN
cord-347986-ds5hm731	184	41	of	of	IN
cord-347986-ds5hm731	184	42	tuberculosis	tuberculosis	NN
cord-347986-ds5hm731	184	43	,	,	,
cord-347986-ds5hm731	184	44	and	and	CC
cord-347986-ds5hm731	184	45	the	the	DT
cord-347986-ds5hm731	184	46	development	development	NN
cord-347986-ds5hm731	184	47	of	of	IN
cord-347986-ds5hm731	184	48	MDR	MDR	NNP
cord-347986-ds5hm731	184	49	-	-	HYPH
cord-347986-ds5hm731	184	50	TB	TB	NNP
cord-347986-ds5hm731	184	51	.	.	.
cord-347986-ds5hm731	185	1	It	-PRON-	PRP
cord-347986-ds5hm731	185	2	is	be	VBZ
cord-347986-ds5hm731	185	3	clear	clear	JJ
cord-347986-ds5hm731	185	4	that	that	IN
cord-347986-ds5hm731	185	5	although	although	IN
cord-347986-ds5hm731	185	6	drug	drug	NN
cord-347986-ds5hm731	185	7	and	and	CC
cord-347986-ds5hm731	185	8	vaccine	vaccine	NN
cord-347986-ds5hm731	185	9	development	development	NN
cord-347986-ds5hm731	185	10	for	for	IN
cord-347986-ds5hm731	185	11	both	both	DT
cord-347986-ds5hm731	185	12	avian	avian	JJ
cord-347986-ds5hm731	185	13	influenza	influenza	NN
cord-347986-ds5hm731	185	14	and	and	CC
cord-347986-ds5hm731	185	15	MDR	MDR	NNP
cord-347986-ds5hm731	185	16	-	-	HYPH
cord-347986-ds5hm731	185	17	TB	TB	NNP
cord-347986-ds5hm731	185	18	is	be	VBZ
cord-347986-ds5hm731	185	19	well	well	RB
cord-347986-ds5hm731	185	20	underway	underway	JJ
cord-347986-ds5hm731	185	21	,	,	,
cord-347986-ds5hm731	185	22	there	there	EX
cord-347986-ds5hm731	185	23	is	be	VBZ
cord-347986-ds5hm731	185	24	so	so	RB
cord-347986-ds5hm731	185	25	much	much	RB
cord-347986-ds5hm731	185	26	more	more	JJR
cord-347986-ds5hm731	185	27	that	that	DT
cord-347986-ds5hm731	185	28	needs	need	VBZ
cord-347986-ds5hm731	185	29	to	to	TO
cord-347986-ds5hm731	185	30	be	be	VB
cord-347986-ds5hm731	185	31	done	do	VBN
cord-347986-ds5hm731	185	32	.	.	.
cord-347986-ds5hm731	186	1	Currently	currently	RB
cord-347986-ds5hm731	186	2	,	,	,
cord-347986-ds5hm731	186	3	it	-PRON-	PRP
cord-347986-ds5hm731	186	4	is	be	VBZ
cord-347986-ds5hm731	186	5	the	the	DT
cord-347986-ds5hm731	186	6	developing	develop	VBG
cord-347986-ds5hm731	186	7	world	world	NN
cord-347986-ds5hm731	186	8	which	which	WDT
cord-347986-ds5hm731	186	9	is	be	VBZ
cord-347986-ds5hm731	186	10	most	most	RBS
cord-347986-ds5hm731	186	11	affected	affect	VBN
cord-347986-ds5hm731	186	12	by	by	IN
cord-347986-ds5hm731	186	13	both	both	DT
cord-347986-ds5hm731	186	14	of	of	IN
cord-347986-ds5hm731	186	15	these	these	DT
cord-347986-ds5hm731	186	16	infections	infection	NNS
cord-347986-ds5hm731	186	17	;	;	:
cord-347986-ds5hm731	186	18	yet	yet	CC
cord-347986-ds5hm731	186	19	,	,	,
cord-347986-ds5hm731	186	20	the	the	DT
cord-347986-ds5hm731	186	21	drugs	drug	NNS
cord-347986-ds5hm731	186	22	and	and	CC
cord-347986-ds5hm731	186	23	vaccines	vaccine	NNS
cord-347986-ds5hm731	186	24	are	be	VBP
cord-347986-ds5hm731	186	25	not	not	RB
cord-347986-ds5hm731	186	26	being	be	VBG
cord-347986-ds5hm731	186	27	optimized	optimize	VBN
cord-347986-ds5hm731	186	28	for	for	IN
cord-347986-ds5hm731	186	29	these	these	DT
cord-347986-ds5hm731	186	30	areas	area	NNS
cord-347986-ds5hm731	186	31	.	.	.
cord-347986-ds5hm731	187	1	Drug	drug	NN
cord-347986-ds5hm731	187	2	regimens	regimen	NNS
cord-347986-ds5hm731	187	3	need	need	VBP
cord-347986-ds5hm731	187	4	to	to	TO
cord-347986-ds5hm731	187	5	be	be	VB
cord-347986-ds5hm731	187	6	shorter	short	JJR
cord-347986-ds5hm731	187	7	and	and	CC
cord-347986-ds5hm731	187	8	simpler	simple	JJR
cord-347986-ds5hm731	187	9	,	,	,
cord-347986-ds5hm731	187	10	not	not	RB
cord-347986-ds5hm731	187	11	only	only	RB
cord-347986-ds5hm731	187	12	to	to	TO
cord-347986-ds5hm731	187	13	make	make	VB
cord-347986-ds5hm731	187	14	them	-PRON-	PRP
cord-347986-ds5hm731	187	15	affordable	affordable	JJ
cord-347986-ds5hm731	187	16	to	to	IN
cord-347986-ds5hm731	187	17	the	the	DT
cord-347986-ds5hm731	187	18	population	population	NN
cord-347986-ds5hm731	187	19	at	at	IN
cord-347986-ds5hm731	187	20	risk	risk	NN
cord-347986-ds5hm731	187	21	but	but	CC
cord-347986-ds5hm731	187	22	also	also	RB
cord-347986-ds5hm731	187	23	to	to	TO
cord-347986-ds5hm731	187	24	prevent	prevent	VB
cord-347986-ds5hm731	187	25	the	the	DT
cord-347986-ds5hm731	187	26	development	development	NN
cord-347986-ds5hm731	187	27	of	of	IN
cord-347986-ds5hm731	187	28	drug	drug	NN
cord-347986-ds5hm731	187	29	resistance	resistance	NN
cord-347986-ds5hm731	187	30	.	.	.
cord-347986-ds5hm731	188	1	Vaccines	vaccine	NNS
cord-347986-ds5hm731	188	2	of	of	IN
cord-347986-ds5hm731	188	3	more	more	RBR
cord-347986-ds5hm731	188	4	widespread	widespread	JJ
cord-347986-ds5hm731	188	5	efficacy	efficacy	NN
cord-347986-ds5hm731	188	6	are	be	VBP
cord-347986-ds5hm731	188	7	also	also	RB
cord-347986-ds5hm731	188	8	needed	need	VBN
cord-347986-ds5hm731	188	9	to	to	TO
cord-347986-ds5hm731	188	10	protect	protect	VB
cord-347986-ds5hm731	188	11	as	as	RB
cord-347986-ds5hm731	188	12	well	well	RB
cord-347986-ds5hm731	188	13	as	as	IN
cord-347986-ds5hm731	188	14	prevent	prevent	VB
cord-347986-ds5hm731	188	15	these	these	DT
cord-347986-ds5hm731	188	16	infections	infection	NNS
cord-347986-ds5hm731	188	17	from	from	IN
cord-347986-ds5hm731	188	18	becoming	become	VBG
cord-347986-ds5hm731	188	19	global	global	JJ
cord-347986-ds5hm731	188	20	epidemics	epidemic	NNS
cord-347986-ds5hm731	188	21	.	.	.
cord-347986-ds5hm731	189	1	Hopefully	hopefully	RB
cord-347986-ds5hm731	189	2	,	,	,
cord-347986-ds5hm731	189	3	this	this	DT
cord-347986-ds5hm731	189	4	review	review	NN
cord-347986-ds5hm731	189	5	has	have	VBZ
cord-347986-ds5hm731	189	6	demonstrated	demonstrate	VBN
cord-347986-ds5hm731	189	7	the	the	DT
cord-347986-ds5hm731	189	8	impact	impact	NN
cord-347986-ds5hm731	189	9	for	for	IN
cord-347986-ds5hm731	189	10	all	all	DT
cord-347986-ds5hm731	189	11	mankind	mankind	NN
cord-347986-ds5hm731	189	12	of	of	IN
cord-347986-ds5hm731	189	13	emerging	emerge	VBG
cord-347986-ds5hm731	189	14	infections	infection	NNS
cord-347986-ds5hm731	189	15	in	in	IN
cord-347986-ds5hm731	189	16	the	the	DT
cord-347986-ds5hm731	189	17	developing	develop	VBG
cord-347986-ds5hm731	189	18	world	world	NN
cord-347986-ds5hm731	189	19	and	and	CC
cord-347986-ds5hm731	189	20	will	will	MD
cord-347986-ds5hm731	189	21	stimulate	stimulate	VB
cord-347986-ds5hm731	189	22	ongoing	ongoing	JJ
cord-347986-ds5hm731	189	23	development	development	NN
cord-347986-ds5hm731	189	24	of	of	IN
cord-347986-ds5hm731	189	25	approaches	approach	NNS
cord-347986-ds5hm731	189	26	aimed	aim	VBN
cord-347986-ds5hm731	189	27	at	at	IN
cord-347986-ds5hm731	189	28	addressing	address	VBG
cord-347986-ds5hm731	189	29	these	these	DT
cord-347986-ds5hm731	189	30	issues	issue	NNS
cord-347986-ds5hm731	189	31	for	for	IN
cord-347986-ds5hm731	189	32	the	the	DT
cord-347986-ds5hm731	189	33	people	people	NNS
cord-347986-ds5hm731	189	34	affected	affect	VBN
cord-347986-ds5hm731	189	35	,	,	,
cord-347986-ds5hm731	189	36	and	and	CC
cord-347986-ds5hm731	189	37	for	for	IN
cord-347986-ds5hm731	189	38	the	the	DT
cord-347986-ds5hm731	189	39	entire	entire	JJ
cord-347986-ds5hm731	189	40	world	world	NN
cord-347986-ds5hm731	189	41	.	.	.
cord-347986-ds5hm731	190	1	European	European	NNP
cord-347986-ds5hm731	190	2	Concerted	Concerted	NNP
cord-347986-ds5hm731	190	3	Action	Action	NNP
cord-347986-ds5hm731	190	4	on	on	IN
cord-347986-ds5hm731	190	5	New	New	NNP
cord-347986-ds5hm731	190	6	Generation	Generation	NNP
cord-347986-ds5hm731	190	7	Genetic	Genetic	NNP
cord-347986-ds5hm731	190	8	Markers	Markers	NNPS
cord-347986-ds5hm731	190	9	and	and	CC
cord-347986-ds5hm731	190	10	Techniques	Techniques	NNPS
cord-347986-ds5hm731	190	11	for	for	IN
cord-347986-ds5hm731	190	12	the	the	DT
cord-347986-ds5hm731	190	13	Epidemiology	Epidemiology	NNP
cord-347986-ds5hm731	190	14	and	and	CC
cord-347986-ds5hm731	190	15	Control	Control	NNP
cord-347986-ds5hm731	190	16	of	of	IN
cord-347986-ds5hm731	190	17	Tuberculosis	Tuberculosis	NNP
cord-347986-ds5hm731	190	18	Abstract	Abstract	NNP
cord-347986-ds5hm731	190	19	F-1467	F-1467	NNP
cord-347986-ds5hm731	190	20	,	,	,
cord-347986-ds5hm731	190	21	45th	45th	JJ
cord-347986-ds5hm731	190	22	ICAAC	ICAAC	NNP
cord-347986-ds5hm731	190	23	Abstract	Abstract	NNP
cord-347986-ds5hm731	190	24	F-1116	f-1116	NN
cord-347986-ds5hm731	190	25	,	,	,
cord-347986-ds5hm731	190	26	44th	44th	JJ
cord-347986-ds5hm731	190	27	ICAAC	ICAAC	NNP
cord-347986-ds5hm731	190	28	Proc	proc	NN
cord-347986-ds5hm731	190	29	.	.	.
cord-347986-ds5hm731	191	1	Acad	Acad	NNP