id author title date pages extension mime words sentences flesch summary cache txt cord-320709-2pnqpljt Munster, Vincent J. Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) 2016-02-22 .txt text/plain 3951 219 53 The Mx1, ISG56 and RANTES gene expression in the lungs of Jamaican fruit bats was analyzed as an indicator of the induction of an innate immune response to MERS-CoV infection. The tissue tropism of MERS-CoV in Jamaican fruit bats is comparable to the respiratory tract tropism observed in dromedary camels and humans 49, 50 . MERS-CoV and related batCoV-HKU4 can inhibit innate immune signaling in a variety of human cell lines in vitro via the ORF4b-encoded accessory proteins 52 Lungs of Jamaican fruit bat 5 were stained with α -cytokeratin as an epithelial marker (purple) and with a polyclonal α -coronavirus antibody (brown-red) to demonstrate that viral antigen was located along the basement membrane of alveolar pneumocytes of bat 1 at 2 dpi (indicated by black arrows). Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels ./cache/cord-320709-2pnqpljt.txt ./txt/cord-320709-2pnqpljt.txt