id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000547-adfigzc1	Beniac, Daniel R.	The Organisation of Ebola Virus Reveals a Capacity for Extensive, Modular Polyploidy	2012-01-11		.txt	text/plain	7782	392	51	METHODOLOGY AND PRINCIPAL FINDINGS: We have investigated the structure of Ebola virus using a combination of cryo-electron microscopy, cryo-electron tomography, sub-tomogram averaging, and single particle image processing. Here we report the three-dimensional structure and architecture of Ebola virus and establish that multiple copies of the RNA genome can be packaged to produce polyploid virus particles, through an extreme degree of length polymorphism. From the same image data set, we combined extracted volumes from tomograms with 2-D single particle processing to determine the structure of the GP spikes ( Figure 5 ) to a resolution of 14 Å as measured by the Fourier Shell Correlation (FSC) 0.5 criterion. Analysis of 2090 distinct intact virions with a nucleocapsid from cryo-electron micrographs shows that the most common class length (53%) of virus particles is 982679 nm ( Figure 1A , Table S1 ).	./cache/cord-000547-adfigzc1.txt	./txt/cord-000547-adfigzc1.txt