id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003779-5yhoiv76	Singleton, Courtney D.	Identification of Ebola Virus Inhibitors Targeting GP2 Using Principles of Molecular Mimicry	2019-07-17		.txt	text/plain	8976	434	48	Molecular dynamics simulations of the two most potent candidates in their DOCK-predicted binding poses indicate that the majority of favorable interactions involve seven highly conserved residues that can be used to guide further inhibitor development and refinement targeting EBOV. The computational screening resulted in the prioritization and purchase of 165 compounds for experimental characterization, which led to 11 hits that inhibit viral entry in both EBOV-GP-pseudotyped virus and EBOV transcription-and replicationcompetent virus-like particle (trVLP) systems. Molecular dynamics (MD) simulations in conjunction with genome analysis identified 7 highly conserved residues across different Ebola virus strains (E564.A, A568.A, L571.A, F572.A, T566.C, L569.C, and L573.C) that contribute a majority of the favorable interactions between the compounds and GP2.	./cache/cord-003779-5yhoiv76.txt	./txt/cord-003779-5yhoiv76.txt