id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004069-nuep8nim	DeWald, Lisa Evans	In Vivo Activity of Amodiaquine against Ebola Virus Infection	2019-12-27		.txt	text/plain	5707	288	53	A pharmacokinetic (PK) study in rhesus macaques (2 groups of 2 males and 2 females) was performed to monitor plasma concentrations of AQ (Fig. 1a ) and the active metabolite DEAQ (Fig. 1b) . samples from infected animals collected on days 0, 3, 5, and 7 postexposure and on day of necropsy (days 6, 7 or 8) were analyzed for determination of plasma levels of AQ and its metabolite DEAQ. Animals that were treated on days 0, 1 and 2 (Group 2, Fig. 7a ), had plasma DEAQ levels ranging from 0 to 205 ng/ml on days 3, 5, 7 and 8 postexposure. www.nature.com/scientificreports www.nature.com/scientificreports/ The goal of the study was to treat animals with AQ using a similar dosing strategy as for human patients, with a target blood concentration range of the parent compound AQ of 29.2 ± 10.9 ng/mL 12 .	./cache/cord-004069-nuep8nim.txt	./txt/cord-004069-nuep8nim.txt