id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017811-w38mbvdw	Volchkov, Viktor	Proteolytic Processing of Filovirus Glycoproteins	2018-02-16		.txt	text/plain	3525	186	53	After entering cells by macropinocytosis, the glycan cap and the mucin-like domain are removed from GP1 by endosomal cathepsins B and L exposing the binding site for the Niemann-Pick C1 receptor. The surface glycoprotein of MARV is proteolytically processed in a similar way as that of EBOV; two precursor molecules and mature GP1,2 consisting of the disulfide-linked cleavage products GP1 and GP2 were identified in cells expressing MARV GP and in Marburg virions (Volchkov et al. Like EBOV, MARV enters cells by macropinocytosis and endosomal fusion, but there are some differences in the structure and in endosomal processing of the glycoproteins. Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression Endoproteolytic processing of the Ebola virus envelope glycoprotein: cleavage is not required for function	./cache/cord-017811-w38mbvdw.txt	./txt/cord-017811-w38mbvdw.txt