id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256187-ofp7tupv	Kühl, A.	How Ebola Virus Counters the Interferon System	2012-09-07		.txt	text/plain	8609	439	49	Furthermore, VP24 can shut down the host's IFN-a/b and IFN-c Recognition of viral pathogen-associated molecular patterns (PAMPs) by PRRs (purple) in infected cells initiates a signalling cascade including adaptor molecules (blue) and kinases (green), which activate transcription factors (red) that induce the expression of type I IFNs and ISGs (left panel). Additionally, VP35 blocks multiple steps of the innate antiviral defence (Fig. 4) , such as the signalling pathways leading to the expression of type I IFNs and type I IFN-induced genes, double-stranded (ds) RNA-dependent protein kinase (PKR) translation inhibition and RNA silencing Cárdenas et al., 2006; Feng et al., 2007; Haasnoot et al., 2007) . The tetherin protein (HM1.24, BST-2, CD317) was identified as a type I interferon-inducible host cellular factor, which restricts release of progeny HIV-1 particles from infected cells (Neil et al., 2008; Van Damme et al., 2008) .	./cache/cord-256187-ofp7tupv.txt	./txt/cord-256187-ofp7tupv.txt