id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274377-57zy6unz	Long, Jason	Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry	2015-02-10		.txt	text/plain	3938	205	54	To this end we re-examined the anti-viral properties of CQ, and show here that it inhibited the pH-dependent endosomal entry of a pseudotyped virus (PV) bearing EBOV glycoproteins, in the same way as did the potent and specific vacuolar-ATPase (vATPase) inhibitor bafilyomycin A1 (BafA1) (a non-medical laboratory compound). We also show that licensed and widely used proton pump inhibitors (PPIs) for treatment of gastric acid reflux, omeprazole (OM) and esomeprazole (ESOM), inhibited PV EBOV entry, likely by their off-target inhibitory activity on endosomal vATPase. In this instance, a 'fusion inhibitor' could target the host cell machinery preventing acidification of the endosome, working to inhibit virus entry of several different viruses. Given the volume of research suggesting these off target effects depend on an ability to affect intracellular pH, we hypothesised that these drugs would, like CQ and BafA1, inhibit EBOV, MARV and influenza virus pH dependent entry.	./cache/cord-274377-57zy6unz.txt	./txt/cord-274377-57zy6unz.txt